Search of human proteins with 13325064

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
         (2923 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...  5992   0.0  
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...  3325   0.0  
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...  2980   0.0  
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            605   e-172
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           499   e-140
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            481   e-135
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      444   e-124
gi|16933557 dachsous 1 precursor [Homo sapiens]                       425   e-118
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           407   e-112
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                       399   e-110
gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                      333   1e-90
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        311   5e-84
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        311   5e-84
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        311   5e-84
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        311   8e-84
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        311   8e-84
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   310   1e-83
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        310   1e-83
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]        310   1e-83
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...   310   1e-83
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         295   4e-79
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        295   4e-79
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...   293   2e-78
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...   293   2e-78
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi...   293   2e-78
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi...   293   2e-78
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi...   293   2e-78
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi...   293   2e-78
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi...   293   2e-78
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi...   293   2e-78

>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score = 5992 bits (15545), Expect = 0.0
 Identities = 2923/2923 (100%), Positives = 2923/2923 (100%)

Query: 1    MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPS 60
            MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPS
Sbjct: 1    MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPS 60

Query: 61   SASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIG 120
            SASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIG
Sbjct: 61   SASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIG 120

Query: 121  GHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQ 180
            GHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQ
Sbjct: 121  GHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQ 180

Query: 181  FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGA 240
            FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGA
Sbjct: 181  FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGA 240

Query: 241  VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300
            VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE
Sbjct: 241  VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300

Query: 301  NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360
            NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV
Sbjct: 301  NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360

Query: 361  ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR 420
            ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR
Sbjct: 361  ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR 420

Query: 421  VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
            VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG
Sbjct: 421  VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480

Query: 481  RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
            RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL
Sbjct: 481  RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540

Query: 541  EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTV 600
            EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTV
Sbjct: 541  EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTV 600

Query: 601  LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITS 660
            LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITS
Sbjct: 601  LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITS 660

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVN 720
            QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVN
Sbjct: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVN 720

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS
Sbjct: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT
Sbjct: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900
            DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP
Sbjct: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900

Query: 901  ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960
            ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI
Sbjct: 901  ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960

Query: 961  VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNP 1020
            VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNP
Sbjct: 961  VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNP 1020

Query: 1021 PVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTG 1080
            PVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTG
Sbjct: 1021 PVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTG 1080

Query: 1081 ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPER 1140
            ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPER
Sbjct: 1081 ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPER 1140

Query: 1141 FLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFL 1200
            FLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFL
Sbjct: 1141 FLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFL 1200

Query: 1201 PSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSS 1260
            PSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSS
Sbjct: 1201 PSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSS 1260

Query: 1261 VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG 1320
            VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG
Sbjct: 1261 VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG 1320

Query: 1321 EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITF 1380
            EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITF
Sbjct: 1321 EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITF 1380

Query: 1381 RGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVS 1440
            RGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVS
Sbjct: 1381 RGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVS 1440

Query: 1441 PFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLG 1500
            PFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLG
Sbjct: 1441 PFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLG 1500

Query: 1501 NYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMAD 1560
            NYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMAD
Sbjct: 1501 NYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMAD 1560

Query: 1561 FIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL 1620
            FIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL
Sbjct: 1561 FIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL 1620

Query: 1621 GSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGT 1680
            GSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGT
Sbjct: 1621 GSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGT 1680

Query: 1681 GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS 1740
            GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS
Sbjct: 1681 GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS 1740

Query: 1741 NITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSN 1800
            NITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSN
Sbjct: 1741 NITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSN 1800

Query: 1801 PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPN 1860
            PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPN
Sbjct: 1801 PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPN 1860

Query: 1861 YLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPT 1920
            YLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPT
Sbjct: 1861 YLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPT 1920

Query: 1921 CLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAI 1980
            CLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAI
Sbjct: 1921 CLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAI 1980

Query: 1981 EAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERL 2040
            EAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERL
Sbjct: 1981 EAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERL 2040

Query: 2041 QRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQ 2100
            QRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQ
Sbjct: 2041 QRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQ 2100

Query: 2101 DVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPF 2160
            DVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPF
Sbjct: 2101 DVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPF 2160

Query: 2161 TIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAG 2220
            TIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAG
Sbjct: 2161 TIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAG 2220

Query: 2221 PGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINT 2280
            PGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINT
Sbjct: 2221 PGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINT 2280

Query: 2281 PVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCE 2340
            PVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCE
Sbjct: 2281 PVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCE 2340

Query: 2341 VVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTL 2400
            VVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTL
Sbjct: 2341 VVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTL 2400

Query: 2401 LRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLE 2460
            LRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLE
Sbjct: 2401 LRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLE 2460

Query: 2461 ALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLI 2520
            ALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLI
Sbjct: 2461 ALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLI 2520

Query: 2521 WSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLAL 2580
            WSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLAL
Sbjct: 2521 WSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLAL 2580

Query: 2581 LSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTL 2640
            LSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTL
Sbjct: 2581 LSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTL 2640

Query: 2641 TSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLG 2700
            TSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLG
Sbjct: 2641 TSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLG 2700

Query: 2701 DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG 2760
            DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG
Sbjct: 2701 DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG 2760

Query: 2761 WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSR 2820
            WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSR
Sbjct: 2761 WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSR 2820

Query: 2821 EGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPP 2880
            EGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPP
Sbjct: 2821 EGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPP 2880

Query: 2881 RPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH 2923
            RPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH
Sbjct: 2881 RPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH 2923


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score = 3325 bits (8622), Expect = 0.0
 Identities = 1659/2825 (58%), Positives = 2068/2825 (73%), Gaps = 107/2825 (3%)

Query: 163  PEESLGGRRKRNVNTAPQ----FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEY 218
            PE   G  R+    T+ +    F  P+YQ  + EN+PAGT +  L A    EGE  R+ Y
Sbjct: 223  PEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSY 282

Query: 219  TMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTIL 278
             M+ LFD RS  +F +D  TGAV+T   LDRETK THV RV A D+  P RSA   +T+L
Sbjct: 283  YMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVL 342

Query: 279  VTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE 338
            V DTNDH PVFEQ EY+E +RENLEVGYEVLT+RA+D D+P NAN+ YR+L G+     +
Sbjct: 343  VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW----D 398

Query: 339  VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398
            VF+++  SGV+ TR  +DREE   YQL VEA+DQGR+PGP S TA V++ VED+NDN PQ
Sbjct: 399  VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQ 458

Query: 399  FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV 458
            FSE+ YVVQV EDV     VLRV A+DRD+G NA +HYSI+SGN  GQFYL + +G LDV
Sbjct: 459  FSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDV 518

Query: 459  VSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESV 518
            ++PLD+E  ++Y+L ++AQDGGRPPL N SG+V+VQVLD+NDN PIFVS+PFQATVLE+V
Sbjct: 519  INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578

Query: 519  PLGYLVLHVQAIDADAGDNARLEYRLAGVGH-----------------DFPFTINNGTGW 561
            PLGY V+H+QA+DAD+G+NARL YRL                      DFPF I+N +GW
Sbjct: 579  PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638

Query: 562  ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNE 621
            I+V AELDREEV+ YSFGVEA DHG+P +++S SVS+TVLDVNDN+P FTQP Y +RLNE
Sbjct: 639  ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698

Query: 622  DAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQY 681
            DAAVG+SV+T+ A DRDA+SVITYQ+T GNTRNRF+++SQ GGGL++LALPLDYK E+QY
Sbjct: 699  DAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQY 758

Query: 682  VLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT 741
            VLAVTASDGTR  TA +++NVTDANTHRPVFQSSHYTV+V+EDRP GT++  +SA DEDT
Sbjct: 759  VLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDT 818

Query: 742  GENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
            GENARITY ++D +PQFRID D+G + T  ELDYE+QV+YTL I A+DNGIPQKSDTT L
Sbjct: 819  GENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878

Query: 802  EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
            EIL+ D NDNAPQFL D YQGS++ED PP TS+LQ+SATDRDSG NGR+ YTFQGGDDGD
Sbjct: 879  EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938

Query: 862  GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPMEVTVTVLDVNDNPPV 920
            GDF +E TSG++RT RRLDRENVA Y L A AVD+G P P    +E+ VT+LD+NDN P+
Sbjct: 939  GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998

Query: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
            FE+DE ++FVEEN+P+G  VA++ A DPDEG NAQIMYQIVEG++   FQLD+ +G+L A
Sbjct: 999  FEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRA 1058

Query: 981  LVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSS 1040
            +V+LD+E R EYVLV+QATSAPLVSRATVH+ L+D+NDNPPVL +F+ILFNNYVTN+S+S
Sbjct: 1059 MVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNS 1118

Query: 1041 FPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
            FP G IG +PAHDPD+SDSL Y+F +GNEL L+LL+ +TGEL+LSR LDNNRPLEA+M V
Sbjct: 1119 FPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEV 1178

Query: 1101 LVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATP 1160
             VSDG+HSVTA C LRVTIITD+MLT+SIT+RLE+MS E+FLSPLL LF++ VAA L+T 
Sbjct: 1179 SVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTT 1238

Query: 1161 PDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAIS 1220
             D V VFNVQ DTD    +ILNV+ S   P G  G   F PSEDLQE++YLNR+LLT IS
Sbjct: 1239 KDDVFVFNVQNDTDV-SSNILNVTFSALLPGGVRG--QFFPSEDLQEQIYLNRTLLTTIS 1295

Query: 1221 AQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGF 1280
             QRVLPFDDNICLREPCENYM+CVSVLRFDSSAPF++S++VLFRPIHP+ GLRCRCPPGF
Sbjct: 1296 TQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGF 1355

Query: 1281 TGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNG 1340
            TGDYCETE+DLCYS PCG +GRCRSREGGYTC C + +TGEHCEV ARSGRC  GVCKNG
Sbjct: 1356 TGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNG 1415

Query: 1341 GTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKER 1400
            GTCVNLL+GGF C CP G++E+PYC+VTTRSFP  SF+TFRGLRQRFHFT++L+FAT+ER
Sbjct: 1416 GTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQER 1475

Query: 1401 DGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYY 1460
            +GLLLYNGRFNEKHDF+ALE++ EQVQLTFSAGE+TTTV+P VP GVSDG+WH+VQ++YY
Sbjct: 1476 NGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYY 1535

Query: 1461 NKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLT 1520
            NKP +G  GLP GPS +K+AVVTVD CDT +A+RFG  +GNYSCAAQGTQ GSKKSLDLT
Sbjct: 1536 NKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLT 1595

Query: 1521 GPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDS 1580
            GPLLLGGVP+LPE FPV  RQFVGCMRNL VD +++DMA FIANNGT  GC A++N CD 
Sbjct: 1596 GPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDG 1655

Query: 1581 NTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYL 1640
              C NGGTCVN+W+ + CECPL FGGK+C Q M +PQ F G S+V+W  L++ IS PWYL
Sbjct: 1656 RRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYL 1715

Query: 1641 SLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWH 1700
             LMFRTR+ D VL++A + G ++  LQ+   ++   V        S+ L   R  DG+WH
Sbjct: 1716 GLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWH 1775

Query: 1701 HAQLAL---GASGGPGHAI-LSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVAR 1756
            H  + L          H + ++ DYG  + + ++G  L GL + ++ VGG       V R
Sbjct: 1776 HLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRR 1835

Query: 1757 GFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYS 1816
            GFRGC+QGVR+  TP  V +L+ ++   + V+ GC + DPC S+PCP NS C + W+ YS
Sbjct: 1836 GFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYS 1895

Query: 1817 CSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPR 1876
            C CD GY G NC + C LNPCE+   C R P +P GY CEC P++ GPYCE ++D PCPR
Sbjct: 1896 CVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPR 1955

Query: 1877 GWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVC 1936
            GWWG+P CGPC+C VSKGFDPDCNKT+G+C CKEN+Y+     TCL CDC+P GS SR C
Sbjct: 1956 GWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTC 2015

Query: 1937 DPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1996
            D   GQC CKPGVIGRQC+RCDNPFAEVTT GCEV Y+ CP+A EAGIWWP+T+FG PAA
Sbjct: 2016 DMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAA 2075

Query: 1997 APCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLA 2056
             PCPKGS G AVRHC   +GWLPP LFNCT+I+F +L+   E+L RNE+ +D  R+ QL 
Sbjct: 2076 VPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLV 2135

Query: 2057 LLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALL 2116
              LR+ATQHT   FG+DV+ AYQL   +L HES Q+GF L+ATQD  F E+++  GSALL
Sbjct: 2136 RALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALL 2195

Query: 2117 DTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDK 2176
              A +  WE IQ++EGGTA LL+  E Y S +A+N+R TYL PF IVT N++++V   DK
Sbjct: 2196 APATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDK 2255

Query: 2177 GNFAGAKLPRYEALRGEQPPDLETTVILPESVFR----ETPPVVRPAG---------PGE 2223
             NF GA++PR++ +  E P +LE++V  P   FR    +  P++RPAG         PG 
Sbjct: 2256 FNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGP 2315

Query: 2224 AQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVV 2283
              E E    R+RRHP+ +   AVA VIIYRTL  LLP  YDPD+RSLR+P RPIINTP+V
Sbjct: 2316 GTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMV 2375

Query: 2284 SISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVF 2343
            S  V+ +   LPR L++PV V+F LLE EERTKP+CVFWNHS+ V GTGGWSARGCE++ 
Sbjct: 2376 STLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLS 2435

Query: 2344 RNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRI 2403
            RN +HV+CQC+H  SFAVLMD+SRRENGE+LPLK +TY A+ ++LAALL+ F  L+L+R+
Sbjct: 2436 RNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRM 2495

Query: 2404 LRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALH 2463
            LRSN H I ++L  AL L+QLVF++GINQ + PF CTV+AILLH++Y+ TF+W L+E+LH
Sbjct: 2496 LRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLH 2555

Query: 2464 LYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSF 2523
            +YR LTEVR+++TGPMRFYY++GWG+PA +TGLAVGLDP+GYGNPDFCWLS+ DTLIWSF
Sbjct: 2556 VYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSF 2615

Query: 2524 AGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSV 2583
            AGP+   + ++    +L+A+ SC  +   + KKG VS L+ +F +LLL+SATWLL LL+V
Sbjct: 2616 AGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAV 2675

Query: 2584 NSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALK-LACSRKPSPDPALTTKST-LT 2641
            N D L FHYLFA  + +QGPF+ L + VL++EVRK LK +   RK   + + TT++T LT
Sbjct: 2676 NRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLT 2735

Query: 2642 SSYNCPSPYADG--RLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGL 2699
             S NC + + DG   L    G+S  SL S  R    Q       L   S L  G      
Sbjct: 2736 RSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQK------LGVSSGLVRGSH---- 2785

Query: 2700 GDP-GSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGE 2758
            G+P  SL           D+DSDS+LSL D+QS SYAS+HSSDSE++    EE+      
Sbjct: 2786 GEPDASLMPRSCKDPPGHDSDSDSELSL-DEQSSSYASSHSSDSEDDGVGAEEK------ 2838

Query: 2759 QGWDSLLGPGAERLPLHSTPK-DGGPGPGKAPWPGDFGTTAKESSGNGAP---------- 2807
              WD   G       +HSTPK D       A WP      +     +G P          
Sbjct: 2839 --WDPARG------AVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSV 2890

Query: 2808 ----EERLRENGDALSREGSLGPLPGSSAQP---HKGILKKKCL----PTISEKS--SLL 2854
                EE+    G+    + S G    +S+QP    KGILK K       T++E++    L
Sbjct: 2891 ELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRL 2950

Query: 2855 RLPLEQCTGSSRGSSASEGSRGGP----PPRPPPRQSLQEQLNGVMPIAMSIKAGTVDED 2910
            R  L  C  S   S  S    GGP      + P R+  ++ LNGV   AM+++ G+   D
Sbjct: 2951 REKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGV---AMNVRTGSAQAD 3007

Query: 2911 SSGSE 2915
             S SE
Sbjct: 3008 GSDSE 3012


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score = 2980 bits (7726), Expect = 0.0
 Identities = 1535/2862 (53%), Positives = 1951/2862 (68%), Gaps = 104/2862 (3%)

Query: 105  PAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPR--LRCQSCKLAQAPG------- 155
            P  +  P + R     G  +P+   T PE  P     R   RC+   L Q PG       
Sbjct: 243  PELDSAPRTARTAPASGS-APRESRTAPEPAPKRMRSRGLFRCRF--LPQRPGPRPPGLP 299

Query: 156  LRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGR 215
             R   R    +   R +R  N  PQF   +YQ  VPEN+ AGT V  + A DPD GEAGR
Sbjct: 300  ARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGR 359

Query: 216  LEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATL 275
            L Y++ AL +SRS + FS+DP +G + TA  LDRE+   H  RVTAQDHG PR SA   +
Sbjct: 360  LVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMV 419

Query: 276  TILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLL--EGSG 333
             + V D NDH PVFEQ +Y+E+LREN+E GY +L +RATDGDAPPNAN+ YR +    + 
Sbjct: 420  AVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAAR 479

Query: 334  GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDN 393
             + +  FEIDPRSG+I T G VDRE +ESY+L VEASDQG++PGPRS T  V ++V D+N
Sbjct: 480  AAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEN 539

Query: 394  DNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT 453
            DNAPQFSEKRYV QVREDV P   VLRVTA+DRDK +N +VHY+I+SGN+RG F +D+ T
Sbjct: 540  DNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLT 599

Query: 454  GALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQAT 513
            G + VV+PLD+E  +EY LR+RAQD GRPPLSN +GL ++QV+DIND+ PIFVSTPFQ +
Sbjct: 600  GEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVS 659

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            VLE+ PLG+ V+H+QA+DAD G+NARLEY L GV  D PF IN+ TGW+SV+  LDRE V
Sbjct: 660  VLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESV 719

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVS 633
            + Y FGVEARDHG+P L+ASASV+VTVLDVNDN P FT  EY +RLNEDAAVGTSVV+V+
Sbjct: 720  EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779

Query: 634  AVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ 693
            AVDRDA+S I+YQIT GNTRNRF+I++Q G GLV+LALPLDYK ER + L +TASD    
Sbjct: 780  AVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH 839

Query: 694  DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED 753
            D   + +N+TDANTHRPVFQS+HY+V+VNEDRP G+T+V+ISA+D+D GENARITY +ED
Sbjct: 840  DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 813
            ++PQFRIDAD+GA+T QA LDYEDQV+YTLAITARDNGIPQK+DTTY+E++VNDVNDNAP
Sbjct: 900  NLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP 959

Query: 814  QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
            QF+   Y G V ED PPFTSVLQISATDRD+  NGRV YTFQ G+DGDGDF +E TSGIV
Sbjct: 960  QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019

Query: 874  RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
            RT+RRLDRE V+ Y L AYAVD+G+PP RTP+ + V V DVNDN PVF  +EF+V V+EN
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079

Query: 934  SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYV 993
            S +G  VA++TA DPDEG NA IMYQIVEGNIPE+FQ+DIFSGELTAL+DLDYE R EYV
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139

Query: 994  LVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
            +V+QATSAPLVSRATVHVRL+D+NDN PVL NF+ILFNNYV+NRS +FP G IGR+PA+D
Sbjct: 1140 IVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199

Query: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQC 1113
            PD+SD L YSFERGNEL L+++N ++GEL+LSR LDNNRPL A M V V+DG+HSVTAQC
Sbjct: 1200 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQC 1259

Query: 1114 ALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDT 1173
             LRV IIT+E+L +S+T+RLE+M  ERFLSPLLG F++ VAA LATP + V +FN+Q DT
Sbjct: 1260 VLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDT 1319

Query: 1174 DAPGGHILNVSLSVGQPPGPGGGP--PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNI 1231
            D  GG +LNVS S   P G G G   P+  SE+LQE+LY+ R+ L A S   VLPFDDN+
Sbjct: 1320 DV-GGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNV 1378

Query: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
            CLREPCENYM+CVSVLRFDSSAPF+AS+S LFRPI P+ GLRCRCPPGFTGD+CETE+DL
Sbjct: 1379 CLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDL 1438

Query: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGF 1351
            CYS PC   G C  REGGYTC+CR  +TGE CE+   +GRC PGVC+NGGTC +   GGF
Sbjct: 1439 CYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGF 1498

Query: 1352 KCDCPSGD-FEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRF 1410
            +C CP+G  FE P C+V  RSFP  SF+ FRGLRQRFH TL+LSFAT ++ GLL YNGR 
Sbjct: 1499 RCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRL 1558

Query: 1411 NEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGL 1470
            NEKHDF+ALE++  QV+LT+S GES T VSP VPGG+SDGQWHTV L+YYNKP     G 
Sbjct: 1559 NEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGG 1618

Query: 1471 PQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD 1530
             QGPS+ KVAV++VD CD  VAL+FG+ +GNYSCAA G Q  SKKSLDLTGPLLLGGVP+
Sbjct: 1619 AQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPN 1678

Query: 1531 LPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCV 1590
            LPE+FPV  + F+GCMR+L +D R +DMA F+ANNGT+ GC AK + CDS  C N G C 
Sbjct: 1679 LPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCS 1738

Query: 1591 NQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWH-GLSLPISQPWYLSLMFRTRQA 1649
             +W +FSC+CP+GFGGK C   MA+P HF G+  ++W+ G  + +S PWYL L FRTR  
Sbjct: 1739 ERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRAT 1798

Query: 1650 DGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLAL--G 1707
             GVL+Q      ST+  QL  G + ++V     +AS L L+    +DG WH  +L L   
Sbjct: 1799 QGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEE 1858

Query: 1708 ASGGPGHAIL--SFDYGQQRAEGNLGPRLHGLHLSNITVGGI-PGPAGGVARGFRGCLQG 1764
              G  GH +L  S D+   +    +G  L GL +  + VGG+ PG A    +G  GC+QG
Sbjct: 1859 PGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQG 1918

Query: 1765 VRVSDTPEGVNS-LDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGY 1823
            V +  TP G  + L PSH   +N E GC + + C S PCP ++ C + W ++SC+C PGY
Sbjct: 1919 VWLGSTPSGSPALLPPSH--RVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGY 1976

Query: 1824 YGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPT 1883
            YG  C + C LNPC++Q  C   P APHGYTC+C   Y G +CE R+DQ CPRGWWG PT
Sbjct: 1977 YGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPT 2036

Query: 1884 CGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQC 1943
            CGPCNCDV KGFDP+CNKT+G+CHCKE HYRP GS +CL CDCYP GS SR C P  GQC
Sbjct: 2037 CGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQC 2096

Query: 1944 PCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGS 2003
            PC+PG +GRQC+ CD+PFAEVT +GC V YD+CP+++ +G+WWP+T+FG+ A  PCP+G+
Sbjct: 2097 PCRPGALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGA 2156

Query: 2004 FGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNAT 2063
             G AVR CDE +GWL P+LFNCTS  F EL    + L+ N++ LD+  +++LA  LR  T
Sbjct: 2157 LGAAVRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVT 2216

Query: 2064 QHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRH 2123
             HT  YF  DV+V  +L   LLA ES Q+GFGL+ATQD HF ENLL  GSALL       
Sbjct: 2217 GHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDL 2276

Query: 2124 WELIQQT----EGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNF 2179
            W  + Q       G+A L++H E YA+ LA+NM  TYL+P  +VTPNI++S+ R++  + 
Sbjct: 2277 WAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSS 2336

Query: 2180 --AGAKLPRYEA--LRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQR 2235
                 + PRY +   RG+   D  T V+LP    R +P  V P                 
Sbjct: 2337 PRGARRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPP 2396

Query: 2236 RHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLP 2295
              PE   G ++  +++YRTL GLLP  +  ++R  R+P+ P++N+PVVS++V      L 
Sbjct: 2397 APPEPEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLR 2456

Query: 2296 RALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNH 2355
              L+ P++++FRLL+T  R+K ICV W+   L    G W+AR CE+V RN SH  C+C+ 
Sbjct: 2457 GILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSR 2516

Query: 2356 MTSFAVLMDVSRRE--NGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRR 2413
              +F VLMD S RE   G++  L   T+V + V++AAL+LT   L  LR L+SN  GI  
Sbjct: 2517 TGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHA 2576

Query: 2414 NLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRD 2473
            N+ AALG+A+L+FLLGI++      CT +AILLH+ +L TF+W  ++ LHLYR   E R+
Sbjct: 2577 NVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRN 2636

Query: 2474 VNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSM 2533
            V+ G MRFY+ LGWGVPA + GLAVGLDPEGYGNPDFCW+S+++ LIWSFAGPV   + M
Sbjct: 2637 VDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVM 2696

Query: 2534 SVFLYILAARASCA-AQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHY 2592
            +  +++LAAR SC+  QR+   KK     L+ SF +LLL+SA+WL  LL+VN   L FHY
Sbjct: 2697 NGTMFLLAARTSCSTGQREA--KKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHY 2754

Query: 2593 LFATCNCIQGPFIFLSYVVLSKEVRKALKLAC-SRKPSPDPALTTKSTLTSSYNCPSPYA 2651
            L A    +QG  + L + VL+ + R A   AC  RK +P+ A         +YN  + + 
Sbjct: 2755 LHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFE 2814

Query: 2652 DGRLYQ-PYGDSAGSLHSTSRSGKSQP-------SYI--PFLLREESAL-NPGQGPPGLG 2700
            +  L +   G S  S  S++RSG++Q        SY+    L+R  SA  +         
Sbjct: 2815 ESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHA 2874

Query: 2701 DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG 2760
             P  L +    +    D+DSDSDLSLE+++S S  S+ S D+       +       +  
Sbjct: 2875 GPTDLDVAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQ-- 2932

Query: 2761 WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPG------------DFGT-------TAKES 2801
                    +ERL  H  PKD       + WP              +G+       T+K++
Sbjct: 2933 --------SERLLTH--PKDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDA 2982

Query: 2802 SGNGAPEERLRENGDALSREGSLGPLPGSSAQPHKGILKKKC-LPTISEKSSLLRLPLEQ 2860
            + N  P+  L  +GD  S         G + +  KGILK +   P + +        L  
Sbjct: 2983 ANNNQPDPAL-TSGDETSL--------GRAQRQRKGILKNRLQYPLVPQTRGAPE--LSW 3031

Query: 2861 CTGSSRGSSA---------SEGSRGGPPPRPPPRQSLQEQLN 2893
            C  ++ G  A           G   G   +P  R S +EQL+
Sbjct: 3032 CRAATLGHRAVPAASYGRIYAGGGTGSLSQPASRYSSREQLD 3073


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  605 bits (1560), Expect = e-172
 Identities = 522/1819 (28%), Positives = 814/1819 (44%), Gaps = 195/1819 (10%)

Query: 162  SPEESLGGRRKRNV----NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLE 217
            SP +S   +   N+    + AP+F    + A VPEN P G  V  +   D D G      
Sbjct: 2750 SPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISR 2808

Query: 218  YT-MDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT 276
            Y+ MDA         F+++P TG +  +  L+RE    +  RV+A D G    +    +T
Sbjct: 2809 YSIMDASLP------FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVT 2859

Query: 277  ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
            I VTD ND+ P F +  Y     E  E+G +V  V ATD D   N  + Y +      S 
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIK-----SQ 2914

Query: 337  SEVFEIDPRSGVIRTRGPVDREEVESYQ--------LTVEASDQGRDPGPRSTTAAVFLS 388
            SE F I+  +G I  +  +  + V  +           V +SD+G+      TT  V ++
Sbjct: 2915 SEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT--VTIN 2972

Query: 389  VEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA-SDRDKGSNAVVHYSIMSGNARGQF 447
            + D NDNAPQF + +Y   V ++V  G  ++RVTA  D+D G N+ V Y I + N  G+F
Sbjct: 2973 IVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKF 3032

Query: 448  YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS 507
             LD  TG + V S L  +  + + + V A+D G PPLS+    V + V + N + P F  
Sbjct: 3033 KLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSS-QATVHITVTEENYHTPEFSQ 3091

Query: 508  TPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAE 567
            +   AT+ ES  +G +V  V A D DA  N  ++Y ++    +  F IN+ TG +++A  
Sbjct: 3092 SHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKA 3151

Query: 568  LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGT 627
            LD E    +   + A D G  A T   SV+V V+DVNDN+P F   +Y   + E+A  GT
Sbjct: 3152 LDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGT 3211

Query: 628  SVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAV 685
            +V+ ++A D D+  ++VI Y + S ++ + F I   +  G+++    LD++ ++ Y L V
Sbjct: 3212 TVIHLNATDADSGTNAVIAYTVQSSDS-DLFVIDPNT--GVITTQGFLDFETKQSYHLTV 3268

Query: 686  TA---SDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG 742
             A    D  R   A + + +   N + P F S  Y   ++E  P GT V  + A+D D G
Sbjct: 3269 KAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG 3328

Query: 743  ENARITY--FMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKS--DT 798
             +  + Y  F       F+I+  TG +     LD E +   +L + A++ G  + +  D 
Sbjct: 3329 TDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDE 3388

Query: 799  TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD 858
              + + V D ND  P F  + Y   + E VP  T V  +SA D DS  +   F  F G  
Sbjct: 3389 VTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSG 3447

Query: 859  DGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
            + +G F +   +G +     LDRE +  Y L   AVD G P A     + VT+ D+NDN 
Sbjct: 3448 NENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNG 3507

Query: 919  PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQ--IMYQIVEGNIPEVFQLDIFSG 976
            P+    E +V   EN   G  V  + +TDPD   N      Y +  G     F L   +G
Sbjct: 3508 PMLTVSEGEVM--ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AG 3564

Query: 977  ELTALVDLDYEDRPEYVL--VIQATSAP-LVSRATVHVRLLDRNDNPPVLGNFEILFNNY 1033
             L+   ++D E   ++ L  V + +  P + S  TVH+ ++D+NDNP      EI  N Y
Sbjct: 3565 VLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYY 3624

Query: 1034 VTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLS-RALDNNR 1092
                 + FPGG +G V   DPD+ DS   S   G   SL  +   T +L    R+ D   
Sbjct: 3625 ----GNLFPGGILGSVKPQDPDVLDSFHCSLTSG-VTSLFSIPGGTCDLNSQPRSTDGTF 3679

Query: 1093 PLEAIMSVLVSDGVHS-VTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQ 1151
             L    +VL +DGVHS VT+   +     ++  + +SI LRL   + + FL+     F++
Sbjct: 3680 DL----TVLSNDGVHSTVTSNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNHYLHFLR 3735

Query: 1152 AVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYL 1211
              ++ L      V +++   + +     +  V  +  Q   P G   F  S         
Sbjct: 3736 IASSQLTGLGTAVQLYSAYEENNRT-FLLAAVKRNHNQYVNPSGVATFFES--------- 3785

Query: 1212 NRSLLTAISAQRVLPFDDNICLREPCENYMRCV------SVLRFDSSAPFIASSSVLFRP 1265
             + +L   S  +V   D + C+  PC+N   C+      SVL+   S P I  ++   +P
Sbjct: 3786 IKEILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQP 3845

Query: 1266 I--------------------------------HPVGGLRCRCPPGFTGDYCETEVDLCY 1293
                                             + VGG  C CP GFTG  CE +++ C 
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECL 3905

Query: 1294 SRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKC 1353
              PC     C++  G + C+C+ GYTG+ CE S     C P  C NGG+C +  V  + C
Sbjct: 3906 QSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNP--CFNGGSCQS-GVDSYYC 3962

Query: 1354 DCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYN--GRFN 1411
             CP G F K +C++ +  F   S++ F  L    ++ + + FAT +   LLLYN   +  
Sbjct: 3963 HCPFGVFGK-HCELNSYGFEELSYMEFPSLDPNNNY-IYVKFATIKSHALLLYNYDNQTG 4020

Query: 1412 EKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLP 1471
            ++ +F+ALE+ +E+++ +++ G  T  ++      VSDG +HTV        +  + G+ 
Sbjct: 4021 DRAEFLALEIAEERLRFSYNLGSGTYKLTTMKK--VSDGHFHTV--------IARRAGM- 4069

Query: 1472 QGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDL-TGPLLLGGV-- 1528
                    A +TVD C       +        C           +LD+    + +GG+  
Sbjct: 4070 -------AASLTVDSCSENQEPGY--------CTVSNVAVSDDWTLDVQPNRVTVGGIRS 4114

Query: 1529 --PDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNG 1586
              P L     V    FVGC+    V+ R ++ +  +A  G +  CP  +  C  + C +G
Sbjct: 4115 LEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHG 4174

Query: 1587 GTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL---GSSLVAWH-------------GL 1630
            GTC++ W    C C  G  GK C ++   P   L   G   + +H              L
Sbjct: 4175 GTCMDYWSWQQCHCKEGLTGKYC-EKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSL 4233

Query: 1631 SLPISQPW---YLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSL 1687
               + +P+    L + FRTR  +GVL+  I    +  T++++ G V  + +         
Sbjct: 4234 RGAMLEPFGVNSLEVKFRTRSENGVLIH-IQESSNYTTVKIKNGKVYFTSDAGIAGKVER 4292

Query: 1688 RLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGI 1747
             +      DG WH     +G +G     +LS D    R   +      GL +  I++GGI
Sbjct: 4293 NIPEVYVADGHWH--TFLIGKNGTA--TVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGI 4348

Query: 1748 P---GPAGGVARGFRGCLQGVRVSDTP---EGVNSLDPSHGESINVEQGCSLPDPCDSNP 1801
            P           GF GC+  +          G +SL        +V+ GC  P+ C SNP
Sbjct: 4349 PPNQAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNP 4408

Query: 1802 CPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNY 1861
            C  +  C N W +Y C   PG         C  +PC++   C  +P    G+TC CP ++
Sbjct: 4409 CWGDLLCINQWYAYRC-VPPG--------DCASHPCQNGGSC--EPGLHSGFTCSCPDSH 4457

Query: 1862 LGPYCE---TRIDQPCPRG 1877
             G  CE     +   CP+G
Sbjct: 4458 TGRTCEMVVACLGVLCPQG 4476



 Score =  465 bits (1197), Expect = e-130
 Identities = 324/915 (35%), Positives = 469/915 (51%), Gaps = 51/915 (5%)

Query: 182  QPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM-DALFDSRSNQFFSLDPVTGA 240
            QP  Y  +V EN P GT +  LRA D D G+ G + +++ +A  D RS   F LDPV+G 
Sbjct: 584  QPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRS---FRLDPVSGR 640

Query: 241  VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE 300
            ++T   LDRE ++ +   V A D G P +S++A + + + D ND+ PVF   +Y   ++E
Sbjct: 641  LSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKE 700

Query: 301  NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360
            N   G  + TV ATD D   N  + Y +   S G  S  F+++ +SGVI TR  +DREE 
Sbjct: 701  NEPGGSYITTVSATDPDLGTNGTVKYSI---SAGDRSR-FQVNAQSGVISTRMALDREEK 756

Query: 361  ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR 420
             +YQL + A+D G    P    A V ++V D  DN P FS+  Y   V E+V  G  V  
Sbjct: 757  TAYQLQIVATDGGNLQSPNQ--AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGS 814

Query: 421  VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
            V+AS  D  SN  + Y I +G+ +G F ++  TG L   + +D E    Y L+V A  G 
Sbjct: 815  VSASTMDLNSN--ISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG- 871

Query: 481  RPPLSNVSG--LVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNA 538
                  V+G  +V + V D+NDN+P F+       V+E+   G+ +   +A+D D G N 
Sbjct: 872  -----TVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNG 926

Query: 539  RLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSV 598
             + Y L     +  F IN   G IS+   LD      Y   + A D G P L++S  ++V
Sbjct: 927  MVLYSLKQNPKNL-FAINEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQLSSSVILTV 984

Query: 599  TVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRF 656
             V DVNDN+P F Q  Y V L+E   V +    V A D+D  A+  I Y I  GNT + F
Sbjct: 985  YVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAF 1044

Query: 657  SITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD---TAQIVVNVTDANTHRPVFQ 713
             I      G + +   LD +L+ +YVL V ASD   +    T  + V + D N +RP+F 
Sbjct: 1045 GIFPD---GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFN 1101

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAEL 773
            S++YT    E++ AG+ V  +SA D+D G N  + Y  E   P F + A +G +T   + 
Sbjct: 1102 STNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQF 1161

Query: 774  DYEDQVS------YTLAITARDNGIPQK-SDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826
            D E  +       ++  + A D GIPQ   D   + + + D+NDNAP+FL+D YQ ++ E
Sbjct: 1162 DRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISE 1221

Query: 827  DVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQ 886
                 T VL++SA+D D G NG + Y+   G++ +  F ++STSG V  + +LD E    
Sbjct: 1222 SAANLTQVLRVSASDVDEGNNGLIHYSIIKGNE-ERQFAIDSTSGQVTLIGKLDYEATPA 1280

Query: 887  YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTAT 946
            Y L   AVD G  P  +   + + +LD NDN P F +    V V EN  IG  V+ VTAT
Sbjct: 1281 YSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTAT 1340

Query: 947  DPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS---APL 1003
            D D G NA + Y I   N    F +   +G +     LD+E +  Y L I A      P 
Sbjct: 1341 DSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1400

Query: 1004 VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDP--DISDSLT 1061
             S  +V + + D NDNPP     +I F + V N      G ++  V AHDP  DI+  L+
Sbjct: 1401 SSTMSVVIHVRDFNDNPPSFPPGDI-FKSIVENIPI---GTSVISVTAHDPDADINGQLS 1456

Query: 1062 YS----FERGNELSL 1072
            Y+      RGN  ++
Sbjct: 1457 YTIIQQMPRGNHFTI 1471



 Score =  428 bits (1100), Expect = e-119
 Identities = 328/1019 (32%), Positives = 492/1019 (48%), Gaps = 57/1019 (5%)

Query: 181  FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF---FSLDPV 237
            F   S  A+V EN   GT VA L   D D   A     ++  L  +    F    S  P 
Sbjct: 358  FPATSRYASVDENAQVGTVVALLTVTDADSPAANG-NISVQILGGNEQRHFEVQSSKVPN 416

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQD-HGMP------RRSALATLTILVTDTNDHDPVFE 290
               +  A  LDRE   ++   V+  D +G P       RS++A+L I V D NDH PVF 
Sbjct: 417  LSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFS 476

Query: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350
            QQ Y+ +L E    G  V  + ATDGD+  NAN+ Y ++ G+G      F I   SG++ 
Sbjct: 477  QQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNG---LGWFHISEHSGLVT 533

Query: 351  T--RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSE-KRYVVQ 407
            T   G +DRE      L + A DQG    P+ + A + +++ D ND  P FS+ + Y V 
Sbjct: 534  TGSSGGLDRELASQIVLNISARDQG--VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVS 591

Query: 408  VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNA-RGQFYLDAQTGALDVVSPLDYET 466
            V E+   G  +L + A+D D G N  V +S+      R  F LD  +G L  +S LD E 
Sbjct: 592  VVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREE 651

Query: 467  TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
               Y+L V A D G PP S+++  + V +LDINDN+P+F    + A + E+ P G  +  
Sbjct: 652  QAFYSLLVLATDLGSPPQSSMA-RINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT 710

Query: 527  VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG 586
            V A D D G N  ++Y ++  G    F +N  +G IS    LDREE   Y   + A D G
Sbjct: 711  VSATDPDLGTNGTVKYSIS-AGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQ 646
                   A V++TVLD  DN P F+Q  Y+  + E+ A+G  V +VSA   D +S I+Y 
Sbjct: 770  NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYL 829

Query: 647  ITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDAN 706
            IT+G+ +  F+I   +  G ++ A  +D + +  Y L V AS GT      + + V D N
Sbjct: 830  ITTGDQKGMFAINQVT--GQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLN 887

Query: 707  THRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FRIDADTG 765
             + P F  +  +VNV E+  AG ++    A D D G N  + Y ++ +    F I+   G
Sbjct: 888  DNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNG 947

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
             ++    LD     SY + I A D G+PQ S +  L + V+DVNDN+P F + SY+ ++ 
Sbjct: 948  TISLLGPLDVH-AGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLS 1006

Query: 826  EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVA 885
            E  P  +   ++ A+D+DSG NG + YT   G+ GD   I       +++   LDRE   
Sbjct: 1007 ESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKS--ELDRELQD 1064

Query: 886  QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
            +YVL   A D+ + P    + VTV + DVNDN P+F    +  + EE    G  V +V+A
Sbjct: 1065 RYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSA 1124

Query: 946  TDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPE----------YVLV 995
             D D G N ++ Y      +   F+L   SGE+T     D E               +  
Sbjct: 1125 VDKDFGPNGEVRYSF--EMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIAT 1182

Query: 996  IQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG-GAIGRVPAHDP 1054
             Q    PL  +ATVHV + D NDN P     + L + Y    S S      + RV A D 
Sbjct: 1183 DQGIPQPLKDQATVHVYMKDINDNAP-----KFLKDFYQATISESAANLTQVLRVSASDV 1237

Query: 1055 DISDS--LTYSFERGNELSLVLLNASTGELKLSRALD-NNRPLEAIMSVLVSDGVHSVTA 1111
            D  ++  + YS  +GNE     +++++G++ L   LD    P  +++   V  G   + +
Sbjct: 1238 DEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNS 1297

Query: 1112 QCALRVTIITDEMLTHSI---TLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVF 1167
             C L + I+ +   T S    TL ++ +   R     +G  + +V AT +   D+  ++
Sbjct: 1298 TCTLNIDILDENDNTPSFPKSTLFVDVLENMR-----IGELVSSVTATDSDSGDNADLY 1351



 Score =  425 bits (1093), Expect = e-118
 Identities = 324/999 (32%), Positives = 499/999 (49%), Gaps = 55/999 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F   SY  ++ EN P G+ V      D D+G   +L Y++ A  DS     F++D   
Sbjct: 1942 PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI-ASGDSLGQ--FTVDK-N 1997

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMP-----RRSALATLTILVTDTNDHDPVFEQQE 293
            G +   + LDRE++S   + +  Q H +P     R ++ A ++I++ D ND+ P F   +
Sbjct: 1998 GVLKVLKALDRESQS--FYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPK 2055

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
                + EN  +   V   +ATD D+ PN+ I Y LL   G      F I    G +R  G
Sbjct: 2056 LTY-IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK----FSIGTIDGEVRLTG 2110

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
             +DREEV +Y LTV A+D+G+ P   S+T  V + V D NDN P F++  Y V++ E+  
Sbjct: 2111 ELDREEVSNYTLTVVATDKGQ-PSLSSSTEVVVM-VLDINDNNPIFAQALYKVEINENTL 2168

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
             G  +++V A+D D+G+N  V Y I++GN   +F +D+ TGA+ V  PLD E T  Y L 
Sbjct: 2169 TGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLT 2228

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESV-PLGYLVLHVQAIDA 532
            V+A D G  P ++ S  V++ +LDIND  P+F  +P+   V E++  L   +L V A D 
Sbjct: 2229 VQATDRGSTPRTDTS-TVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD 2287

Query: 533  DAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
            D G N++L Y L G   D  FT++  +G + V   LDRE  + +   + A D G+PALT 
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATDSGSPALTG 2346

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNT 652
            + +++V V DVNDN PTF    Y   + EDA  GT V+ V+A D DA      +I  GN 
Sbjct: 2347 TGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGN- 2405

Query: 653  RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD----TAQIVVNVTDANTH 708
             ++F+I + S G +++ AL LD + +  Y L V  SD    +    +  ++V VTD N +
Sbjct: 2406 -SQFTI-NPSTGQIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN 2462

Query: 709  RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-SIPQFRIDADTGAV 767
             P FQ   Y  ++      G+ V  ++ TD D G N+ + Y +   +  +F ID   GA+
Sbjct: 2463 PPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAI 2522

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
                 L+   +V  T ++  +D G   K+D+T   + V  VN      +R   Q  ++ +
Sbjct: 2523 MAAGPLNGASEV--TFSVHVKDGGSFPKTDST--TVTVRFVNKADFPKVRAKEQTFMFPE 2578

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P +S++    T   S L G     +    +    F ++  +G V   + LD E + +Y
Sbjct: 2579 NQPVSSLV---TTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKY 2635

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN-SPIGLAVARVTAT 946
            V+   A D G PP  +  ++ +TVLDVNDN P+F++D F   + EN SP    +  V+A 
Sbjct: 2636 VVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTVSAM 2693

Query: 947  DPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D D G N Q+ Y+IV GN+   F ++  +GE+ ++  LD E    YVL I+++     S+
Sbjct: 2694 DKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQ 2753

Query: 1007 AT---VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYS 1063
            +T   V + +LD NDN P    F  +F+ +V   S    G  + RV   D DI  +    
Sbjct: 2754 STSVKVMINILDENDNAP---RFSQIFSAHVPENSPL--GYTVTRVTTSDEDIGINAISR 2808

Query: 1064 FERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDE 1123
            +   +      +N STG++ +SR L+        + V   D   +V+    + VT I D 
Sbjct: 2809 YSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDN 2868

Query: 1124 MLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPD 1162
                S T    D        P L      V    AT PD
Sbjct: 2869 APRFSRTSYYLD-------CPELTEIGSKVTQVFATDPD 2900



 Score =  408 bits (1049), Expect = e-113
 Identities = 312/967 (32%), Positives = 476/967 (49%), Gaps = 56/967 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P     ++ EN P GT V S+ A DPD    G+L YT+  +        F++D V 
Sbjct: 1418 PSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTI--IQQMPRGNHFTIDEVK 1475

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMP---RRSALATLTILVTDTNDHDPVFEQQEYK 295
            G + T  E+DRE  +     V A D  +P   RR AL  +TILVTD ND+ P+F  Q   
Sbjct: 1476 GTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNAL 1535

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
             +   +  +G  + T+ A D D   N  I Y ++ G     ++ F +D  SG +R    +
Sbjct: 1536 AA-DPSAVIGSVLTTIMAADPDEGANGEIEYEIINGD----TDTFIVDRYSGDLRVASAL 1590

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
               ++  Y L V A+D G +    +T   + L   D     P F++ +Y+  ++E    G
Sbjct: 1591 VPSQL-IYNLIVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIG 1645

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQ-----FYLDAQTGALDVVSPLDYETTK-E 469
              V+ + A+   +GS A V Y I+S     +     F +   TG +   + LD E     
Sbjct: 1646 TNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACL 1704

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            Y + V A +            V + + DINDN P+F +     TV E++  G  ++ + A
Sbjct: 1705 YLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTA 1764

Query: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
            +DAD G NA + Y +   G D  F I+  +G +     LDRE    YS  V A D     
Sbjct: 1765 MDADEGANALVTYTIIS-GADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG---L 1820

Query: 590  LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
             ++   +++TV DVND+ P F++P Y+  + ED   G+ V  + A D D+  +  ITY +
Sbjct: 1821 QSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIV 1880

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ-DTAQIVVNVTDAN 706
               +    F +   +G  + +L   LDY++++ Y+L V A DG  Q  T ++  N+ D N
Sbjct: 1881 NEDDEDGIFFLNPITG--VFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVN 1938

Query: 707  THRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDADT 764
             + P+F  + Y+ ++ E+ P G+TV++ + TD D G N+++TY +   DS+ QF +D + 
Sbjct: 1939 DNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN- 1997

Query: 765  GAVTTQAELDYEDQVSYTLAITARDNGIPQK-----SDTTYLEILVNDVNDNAPQFLRDS 819
            G +     LD E Q  Y L +   D  +PQ      + T  + I++ DVNDN P FL   
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHD--LPQIPASRFTSTAQVSIILLDVNDNPPTFLSPK 2055

Query: 820  YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
                + E+ P  T V +  ATD DSG N  + YT    +     F + +  G VR    L
Sbjct: 2056 LT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL--NPLGNKFSIGTIDGEVRLTGEL 2112

Query: 880  DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            DRE V+ Y L   A DKG P   +  EV V VLD+NDN P+F Q  + V + EN+  G  
Sbjct: 2113 DREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTD 2172

Query: 940  VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
            + +V A D DEGTN Q+ Y IV GN  + F++D  +G +T    LD E  P Y L +QAT
Sbjct: 2173 IIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQAT 2232

Query: 1000 ---SAPLVSRATVHVRLLDRNDNPPVLGNFEIL-FNNYVTNRSSSFPGGAIGRVPAHDPD 1055
               S P    +TV + LLD ND  PV   FE+  ++  V     + P   I +V A D D
Sbjct: 2233 DRGSTPRTDTSTVSIVLLDINDFVPV---FELSPYSVNVPENLGTLP-RTILQVVARDDD 2288

Query: 1056 --ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQ 1112
               +  L+Y    GNE +   L+AS GEL ++++LD       ++ +  +D G  ++T  
Sbjct: 2289 RGSNSKLSYVLFGGNEDNAFTLSAS-GELGVTQSLDRETKERFVLMITATDSGSPALTGT 2347

Query: 1113 CALRVTI 1119
              + V +
Sbjct: 2348 GTINVIV 2354



 Score =  399 bits (1026), Expect = e-110
 Identities = 313/996 (31%), Positives = 492/996 (49%), Gaps = 75/996 (7%)

Query: 190  VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
            V E QP GT V +++      G   RL         S S+  F+++  TGA+ T   +DR
Sbjct: 51   VLEEQPPGTLVGTIQT---RPGFTYRL---------SESHALFAINSSTGALYTTSTIDR 98

Query: 250  ETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVL 309
            E+  + V  +          + +    +LV D ND+ PVF       + +E+   G +V+
Sbjct: 99   ESLPSDVINLVVLSSAPTYPTEVR---VLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVI 155

Query: 310  TVRATDGDAPPNA--NILYRLLEGSGGSPSEVFEIDPRSGV-----IRTRGPVDREEVES 362
               ATD D   N   +  YR++ G+      +      SG      + ++G +DRE    
Sbjct: 156  LDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQ 215

Query: 363  YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422
            YQL VE  D+G     R     V ++V+D NDN P F    Y   V ED   G+ VL+V 
Sbjct: 216  YQLLVEVEDKGEP--KRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVA 273

Query: 423  ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
            A+D D+G+NA + Y +        F +D +TG + V  PLD+E  ++Y+L V+A D G P
Sbjct: 274  AADADEGTNADIRYRLQDEGT--PFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP 331

Query: 483  PLSNVSGLVTVQVLDINDNAPI-----FVSTPFQATVLESVPLGYLVLHVQAIDADA-GD 536
             L+  +  + +Q+LD+NDN P+     F +T   A+V E+  +G +V  +   DAD+   
Sbjct: 332  SLTGRAEAL-IQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA 390

Query: 537  NARLEYRLAGVGHDFPFTINN----GTGWISVAAELDREEVDFYSFGVEARD-HGTP--- 588
            N  +  ++ G      F + +        I VA+ LDRE +  Y+  V   D +G P   
Sbjct: 391  NGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGA 450

Query: 589  ---ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVI 643
               A ++ AS+ + V D+ND+ P F+Q  Y V L+E+A  G+ V  +SA D D+  ++ +
Sbjct: 451  AVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANL 510

Query: 644  TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD---GTRQDTAQIVV 700
             Y I SGN    F I+  SG      +  LD +L  Q VL ++A D     +   AQ+VV
Sbjct: 511  RYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVV 570

Query: 701  NVTDANTHRPVF-QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP--- 756
             + D N  +PVF Q   Y V+V E+ P GT ++++ ATD D G+N  + + ++++     
Sbjct: 571  TLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRR 630

Query: 757  QFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL 816
             FR+D  +G ++T + LD E+Q  Y+L + A D G P +S    + + + D+NDN+P F 
Sbjct: 631  SFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFY 690

Query: 817  RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
               Y   + E+ P  + +  +SATD D G NG V Y+   GD     F V + SG++ T 
Sbjct: 691  PVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGD--RSRFQVNAQSGVISTR 748

Query: 877  RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
              LDRE    Y L+  A D G   +     VT+TVLD  DNPPVF Q  +   V EN  +
Sbjct: 749  MALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVAL 808

Query: 937  GLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVI 996
            G  V  V+A+  D   N+ I Y I  G+   +F ++  +G+LT    +D E++  Y L +
Sbjct: 809  GYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKV 866

Query: 997  QATSAPLVSRATVHVRLLDRNDNPP-VLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD 1055
             A+   +     V++ + D NDN P  L   E +  N V N  +   G +I +  A DPD
Sbjct: 867  VASGGTVTGDTMVNITVKDLNDNSPHFLQAIESV--NVVENWQA---GHSIFQAKAVDPD 921

Query: 1056 --ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQ 1112
              ++  + YS ++ N  +L  +N   G + L   LD +     I  +L SD GV  +++ 
Sbjct: 922  EGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLDVHAGSYQI-EILASDMGVPQLSSS 979

Query: 1113 CALRVTI--ITD-----EMLTHSITLRLEDMSPERF 1141
              L V +  + D     + L++ +TL   +    RF
Sbjct: 980  VILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF 1015



 Score =  390 bits (1003), Expect = e-108
 Identities = 280/932 (30%), Positives = 447/932 (47%), Gaps = 51/932 (5%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            +  P F   +Y  T+PE+ P GT V  + A D D  +   +            N  F+++
Sbjct: 2359 DNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII-------GGNSQFTIN 2411

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPR-RSALATLTILVTDTNDHDPVFEQQEY 294
            P TG + T+  LDRETK  +   V   D G P   S+  ++ + VTD ND+ P F+   Y
Sbjct: 2412 PSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPY 2471

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
               +      G  V  V  TD D  PN+ + Y L     G  SE F IDP  G I   GP
Sbjct: 2472 VTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL----SGRNSEKFHIDPLRGAIMAAGP 2527

Query: 355  VDREEVESYQLTVEASDQGRDPGPRSTTAAV-FLSVEDDNDNAPQFSEKRYVVQVREDVT 413
            ++     ++  +V   D G  P   STT  V F++  D     P+   K       E+  
Sbjct: 2528 LNGASEVTF--SVHVKDGGSFPKTDSTTVTVRFVNKAD----FPKVRAKEQTFMFPENQP 2581

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
              + V  +T S         + Y I SGN    F +D  TG + +  PLD+E  ++Y + 
Sbjct: 2582 VSSLVTTITGSSL---RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVW 2638

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
            + A+DGG PP S+   L  + VLD+NDNAPIF   PF + +LE++     +L V A+D D
Sbjct: 2639 IEARDGGFPPFSSYEKL-DITVLDVNDNAPIFKEDPFISEILENLS-PRKILTVSAMDKD 2696

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
            +G N +L+Y +     +  F+IN+ TG I     LDRE+V  Y   +++ D G+P+ + S
Sbjct: 2697 SGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTS 2756

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
              V + +LD NDN P F+Q  ++  + E++ +G +V  V+  D D   +++  Y I   +
Sbjct: 2757 VKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDAS 2815

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPV 711
                F+I   +G   + ++ PL+ +   +Y + V+A D     +  + + VTD N + P 
Sbjct: 2816 L--PFTINPSTGD--IVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPR 2871

Query: 712  FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQA 771
            F  + Y ++  E    G+ V  + ATD D G N ++ YF++     FRI+A TG +  + 
Sbjct: 2872 FSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQ 2931

Query: 772  ELDYEDQVSY--------TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGS 823
             L Y++   +        +  +T+ D G P     T + I + D NDNAPQFL+  Y   
Sbjct: 2932 ILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTP 2991

Query: 824  VYEDVPPFTSVLQISA-TDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
            V ++V   T +++++A  D+D GLN  V Y F   D+  G F +++ +G +     L  +
Sbjct: 2992 VTKNVKVGTKLIRVTAIDDKDFGLNSEVEY-FISNDNHLGKFKLDNDTGWISVASSLISD 3050

Query: 883  NVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR 942
                + +   A DKG PP  +   V +TV + N + P F Q      + E+  IG  V  
Sbjct: 3051 LNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRT 3110

Query: 943  VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAP 1002
            V+A D D   N  I Y I  GN   +F ++  +G LT    LDYE   ++ + I A    
Sbjct: 3111 VSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGG 3170

Query: 1003 LVSR---ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHDPDISD 1058
             V+R    +V V ++D NDN PV      L ++Y      + P G  +  + A D D   
Sbjct: 3171 WVARTGYCSVTVNVIDVNDNSPV-----FLSDDYFPTVLENAPSGTTVIHLNATDADSGT 3225

Query: 1059 SLTYSFE-RGNELSLVLLNASTGELKLSRALD 1089
            +   ++  + ++  L +++ +TG +     LD
Sbjct: 3226 NAVIAYTVQSSDSDLFVIDPNTGVITTQGFLD 3257



 Score =  375 bits (964), Expect = e-103
 Identities = 307/1040 (29%), Positives = 483/1040 (46%), Gaps = 68/1040 (6%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + +P F        V EN  AG  +   +A+DPDEG  G + Y++           F+++
Sbjct: 888  DNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK----QNPKNLFAIN 943

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
               G ++    LD    S  +  + A D G+P+ S+   LT+ V D ND+ PVF+Q  Y+
Sbjct: 944  EKNGTISLLGPLDVHAGSYQI-EILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE 1002

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
             +L E+  V      V+A+D D+  N  I Y + EG+ G    +F      G +  +  +
Sbjct: 1003 VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP----DGQLYIKSEL 1058

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            DRE  + Y L V ASD+  +P   S T  V + +ED NDN P F+   Y     E+   G
Sbjct: 1059 DRELQDRYVLMVVASDRAVEP--LSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAG 1116

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET------TKE 469
            + V +V+A D+D G N  V YS      +  F L A +G +      D E+      T  
Sbjct: 1117 SFVGKVSAVDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFDRESLMRRRGTAV 1174

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            ++  V A D G P        V V + DINDNAP F+   +QAT+ ES      VL V A
Sbjct: 1175 FSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSA 1234

Query: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
             D D G+N  + Y +     +  F I++ +G +++  +LD E    YS  ++A D GT  
Sbjct: 1235 SDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP 1294

Query: 590  LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
            L ++ ++++ +LD NDN P+F +    V + E+  +G  V +V+A D D+  ++ + Y I
Sbjct: 1295 LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI 1354

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD---GTRQDTAQIVVNVTD 704
            T  N    FSI+  +G   + LA  LD++ +  Y L +TA D     R  T  +V++V D
Sbjct: 1355 TGTNNHGTFSISPNTGS--IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412

Query: 705  ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ---FRID 761
             N + P F       ++ E+ P GT+V+ ++A D D   N +++Y +   +P+   F ID
Sbjct: 1413 FNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTID 1472

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE---ILVNDVNDNAPQFLRD 818
               G + T AE+D E    + L + A D  +P ++    L+   ILV D+NDN P F+  
Sbjct: 1473 EVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI-- 1530

Query: 819  SYQGSVYEDVPPFTSVL-QISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLR 877
            S      +      SVL  I A D D G NG + Y    GD     FIV+  SG +R   
Sbjct: 1531 SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGD--TDTFIVDRYSGDLRVAS 1588

Query: 878  RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
             L    +  Y L   A D G    ++  E+T+ +  ++   PVF Q ++   ++E  PIG
Sbjct: 1589 ALVPSQLI-YNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYITILKEGEPIG 1645

Query: 938  LAVARVTATDPDEGTNAQIMYQIV-----EGNIPEVFQLDIFSGELTALVDLDYEDRP-- 990
              V  + A  P  G+ A + Y IV     E  +  +F +   +G +     LD E     
Sbjct: 1646 TNVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACL 1704

Query: 991  ---EYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIG 1047
               +   + ++T+ P   RA V + L D NDNPPV     +     +T   +   G  I 
Sbjct: 1705 YLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDML----DLTVEENIGDGSKIM 1760

Query: 1048 RVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            ++ A D D   +  +TY+   G + S   ++  +G+L  +R LD  R  +  + V   DG
Sbjct: 1761 QLTAMDADEGANALVTYTIISGADDSF-RIDPESGDLIATRRLDRERRSKYSLLVRADDG 1819

Query: 1106 VHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVV 1165
            + S   +  + V+ + D     S  +   D+  +     L       VAA LAT  D  V
Sbjct: 1820 LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSL-------VAAILATDDDSGV 1872

Query: 1166 ---VFNVQRDTDAPGGHILN 1182
               +  +  + D  G   LN
Sbjct: 1873 NGEITYIVNEDDEDGIFFLN 1892



 Score =  347 bits (889), Expect = 1e-94
 Identities = 300/997 (30%), Positives = 453/997 (45%), Gaps = 81/997 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF---F 232
            + AP F  PS   T  E+  +G  V    A D D G  G    +   +  + + +F    
Sbjct: 130  DNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDI 189

Query: 233  SLDPV-TGA---VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +L+P   GA   + +   LDRE    +   V  +D G P+R     + + V D ND+ PV
Sbjct: 190  TLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPV 249

Query: 289  FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
            F    Y+  + E+  VG  VL V A D D   NA+I YRL +   G+P   F++DP +G+
Sbjct: 250  FGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD--EGTP---FQMDPETGL 304

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQF----SEKRY 404
            I  R P+D E    Y LTV+A D+G         A + L   +DND   +F    +  RY
Sbjct: 305  ITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRY 364

Query: 405  VVQVREDVTPGAPVLRVTASDRDK-GSNAVVHYSIMSGNARGQFYLDA----QTGALDVV 459
               V E+   G  V  +T +D D   +N  +   I+ GN +  F + +        + V 
Sbjct: 365  -ASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVA 423

Query: 460  SPLDYETTKEYTLRVRAQDG-GRPP------LSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
            S LD E    Y L V   D  G PP       S+V+ LV + V DIND+ P+F    ++ 
Sbjct: 424  SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLV-IFVNDINDHPPVFSQQVYRV 482

Query: 513  TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAE----- 567
             + E  P G  V  + A D D+G NA L Y +            NG GW  ++       
Sbjct: 483  NLSEEAPPGSYVSGISATDGDSGLNANLRYSIVS---------GNGLGWFHISEHSGLVT 533

Query: 568  ------LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPE-YTVRLN 620
                  LDRE        + ARD G     + A + VT+LDVND  P F+QPE Y V + 
Sbjct: 534  TGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVV 593

Query: 621  EDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678
            E+A  GT ++ + A D D   +  + + +    T +R S       G +S    LD + +
Sbjct: 594  ENAPTGTELLMLRATDGDLGDNGTVRFSLQEAET-DRRSFRLDPVSGRLSTISSLDREEQ 652

Query: 679  RQYVLAVTASD---GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLIS 735
              Y L V A+D     +   A+I V++ D N + PVF    Y  ++ E+ P G+ +  +S
Sbjct: 653  AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712

Query: 736  ATDEDTGENARITYFME-DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQ 794
            ATD D G N  + Y +      +F+++A +G ++T+  LD E++ +Y L I A D G  Q
Sbjct: 713  ATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQ 772

Query: 795  KSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
              +   + I V D  DN P F + +Y   V+E+V     V  +SA+  D  LN  + Y  
Sbjct: 773  SPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLI 830

Query: 855  QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDV 914
              GD   G F +   +G + T   +DRE  + Y L+  A   G     T   V +TV D+
Sbjct: 831  TTGDQ-KGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-SGGTVTGDT--MVNITVKDL 886

Query: 915  NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIF 974
            NDN P F Q    V V EN   G ++ +  A DPDEG N  ++Y + + N   +F ++  
Sbjct: 887  NDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEK 945

Query: 975  SGELTALVDLDYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFN 1031
            +G ++ L  LD      Y + I A+      L S   + V + D NDN PV         
Sbjct: 946  NGTISLLGPLDVH-AGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL----- 999

Query: 1032 NYVTNRSSSFP-GGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
            +Y    S S P      +V A D D   +  + Y+   GN      +    G+L +   L
Sbjct: 1000 SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGI-FPDGQLYIKSEL 1058

Query: 1089 DNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIITDEM 1124
            D       ++ V+ SD  V  ++A   + VT+I +++
Sbjct: 1059 DRELQDRYVLMVVASDRAVEPLSA--TVNVTVILEDV 1093



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 33/117 (28%), Positives = 48/117 (41%), Gaps = 19/117 (16%)

Query: 1795 DPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC---TNVCDLNPCEHQSVCTRKPSAPH 1851
            D C  +PC +   C N    +SCSC  G+ G  C    N C  +PC++ ++C   P +  
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGS-- 3921

Query: 1852 GYTCECPPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHC 1908
             + C C   Y G  CE+ ++         +  C PC      G        S  CHC
Sbjct: 3922 -FNCVCKTGYTGKMCESSVN---------YCECNPC----FNGGSCQSGVDSYYCHC 3964



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 43/147 (29%), Positives = 56/147 (38%), Gaps = 23/147 (15%)

Query: 1842 VCTRKPSAPHGYTCECPPNYLGPYCETRIDQ----PCPRGWWGHPTCGPCNCDVSKGF-D 1896
            +   +P  P  + C+C P Y G +CE  ID+    PC  G   H   G  +C    GF  
Sbjct: 3837 IVANEPLQP--FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTG 3894

Query: 1897 PDCNKTSGEC---HCKENH--YRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIG 1951
              C +   EC    CK        PGS  C+      TG   ++C+     C C P   G
Sbjct: 3895 RACERDINECLQSPCKNGAICQNFPGSFNCVC----KTGYTGKMCESSVNYCECNPCFNG 3950

Query: 1952 RQCDR------CDNPFAEVTTNGCEVN 1972
              C        C  PF  V    CE+N
Sbjct: 3951 GSCQSGVDSYYCHCPFG-VFGKHCELN 3976



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 41/159 (25%), Positives = 57/159 (35%), Gaps = 28/159 (17%)

Query: 1815 YSCSCDPGYYGDNC---TNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRID 1871
            + C C PGY G  C    + C  +PC     C    +   G++C CP  + G  CE  I+
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTC---HNLVGGFSCSCPDGFTGRACERDIN 3902

Query: 1872 Q----PCPRGWWGHPTCGPCNCDVSKGFDPD-CNKTSGECHCKENHYRPPGSPTCLLCDC 1926
            +    PC  G       G  NC    G+    C  +   C C                 C
Sbjct: 3903 ECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECN---------------PC 3947

Query: 1927 YPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVT 1965
            +  GS     D     C C  GV G+ C+     F E++
Sbjct: 3948 FNGGSCQSGVD--SYYCHCPFGVFGKHCELNSYGFEELS 3984


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  499 bits (1286), Expect = e-140
 Identities = 419/1475 (28%), Positives = 658/1475 (44%), Gaps = 170/1475 (11%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM--DALFDSRSNQFFSLDP 236
            P+F  P Y  TV E+ P GT +  +RA       +G + Y++      +S  ++ F +D 
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRA-----EHSGTVLYSLVKGNTPESNRDESFVIDR 2755

Query: 237  VTGAVTTAEELDRETKSTHVF----RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292
             +G +   + LD ET   + F    R T  DH M    A   ++I V D ND+ PVFE  
Sbjct: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMV---ASVDVSIQVKDANDNSPVFESS 2812

Query: 293  EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTR 352
             Y+  + ENL  G  V+ +RA+D D+  N  ++Y L +       E F I+  +G I T 
Sbjct: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTL 2872

Query: 353  GPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
              +D E+ ++YQ+ V ASD G +    S+TA V ++V D ND+ P+F+ + Y   V ED 
Sbjct: 2873 KELDHEKRDNYQIKVVASDHG-EKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD 2931

Query: 413  TPGAPVLRVTASDRDKGS-NAVVHYSIMSGNARGQFYLDA--QTGALDVVSPLDYETTKE 469
              G  +  ++ +D D    N  V Y I  G+  GQF ++       + V  PLD E    
Sbjct: 2932 PQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            Y L + A DG      +   +V V+VLD NDN+P+   T +  T+ E V  G L++ + A
Sbjct: 2992 YLLTITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISA 3047

Query: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
             DAD   NA + Y L G G +  F +N  TG +  +  LDREE   Y   V A D G   
Sbjct: 3048 TDADIRSNAEITYTLLGSGAE-KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG--G 3104

Query: 590  LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
                AS+ +T+ DVNDN P F+   Y + + E+   GT +  V A D DA  +  I Y +
Sbjct: 3105 RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL 3164

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG----TRQDTAQIVVNVT 703
               +   +FSI   SG  ++ L  PLD +L+  Y L++ A D         T  ++V+V 
Sbjct: 3165 ID-SADGQFSINELSG--IIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL 3221

Query: 704  DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRID 761
            D N + PVF+   Y   V+ED   GT V+ + A   D   NA ITY +   +   +F ID
Sbjct: 3222 DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSID 3281

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
            + TGAV     LDYE    Y L + A D G P  SD   + + V D+NDN P F +D+Y 
Sbjct: 3282 SKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYT 3341

Query: 822  GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
              + ED     SV+ + A D D   N  + Y+   G+ G   F ++   G V+  + LDR
Sbjct: 3342 TVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDPVRGEVKVTKLLDR 3400

Query: 882  ENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941
            E ++ Y L   A D G PP      V + V DVNDN PVF +  + V ++EN P+G +V 
Sbjct: 3401 ETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVL 3460

Query: 942  RVTATDPDEGTNAQ-IMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS 1000
            ++  TD D   N     + IV GN  + F+++   G L     +  +++  Y+L ++   
Sbjct: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD 3519

Query: 1001 --APLVSRAT-VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDIS 1057
               P +S  T + +R+++ +  PP +   EI    ++T+    + GG IG++ A D D+ 
Sbjct: 3520 NGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSGGVIGKIHATDQDVY 3575

Query: 1058 DSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRV 1117
            D+LTYS +   + +L  ++++ G+L   + LD  + L   ++V V+DG  +  A   + +
Sbjct: 3576 DTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIGQYL---LNVSVTDGKFTTVADITVHI 3631

Query: 1118 TIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPG 1177
              +T EML H+I +R  +++PE F+      F +A+   L    + + + ++Q     P 
Sbjct: 3632 RQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEPHPH 3691

Query: 1178 GHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPC 1237
               L+V L V +P     G   + ++ L  ++  + + +  I   R+L     +C    C
Sbjct: 3692 ---LDVLLFVEKP-----GSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDC 3743

Query: 1238 ENYMRCVSVLRFDSSAPFIASSSVL--FRPIHPVGGL----RCRCPPGFTGDYCETEVDL 1291
              +  C   +  D S     S++ L    P H    +      RCPP   G         
Sbjct: 3744 P-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHG--------- 3793

Query: 1292 CYSRPCGPHGRCRSR--EGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVG 1349
            C   PC     C S   E  +TC+C  G  G+                            
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ---------------------------- 3825

Query: 1350 GFKCDCPSGDFEKPYCQVTTRSFPAHSFITFR--GLRQRFHFTLALSFATKERDGLLLYN 1407
                 CP           ++ +   +S++ +R      +    L +   T     +++Y 
Sbjct: 3826 -----CPGS---------SSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMY- 3870

Query: 1408 GRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQ 1467
                   D+  LE+   ++Q  F  G     VS      V+DGQWH V L+         
Sbjct: 3871 ---ARGTDYSILEIHHGRLQYKFDCGSGPGIVS-VQSIQVNDGQWHAVALE--------- 3917

Query: 1468 TGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGG 1527
                            V+G        +  ++ +    A GT  G+ K+L+L   +  GG
Sbjct: 3918 ----------------VNG-------NYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGG 3954

Query: 1528 VPDLPESFPVRMRQ----FVGCM-------RNLQVDSRHIDMADFIANNGTVPGC-PAKK 1575
                  +   R  Q    F GCM       + L ++S+    A    +    PGC     
Sbjct: 3955 HIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTAT 4014

Query: 1576 NVCDSNTCHNGGTC-VNQWDAFSCECPLGFGGKSC 1609
              C SN C NGG C  +    + C+C   + G  C
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHC 4049



 Score =  464 bits (1194), Expect = e-130
 Identities = 321/947 (33%), Positives = 482/947 (50%), Gaps = 41/947 (4%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            +P F    Y+  + EN P  T V  ++  D D G  G + Y +  + D   ++F+  +  
Sbjct: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI--VNDFAKDRFYINE-- 2544

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
             G + T E+LDRET +  V  V         + A  T+ +++TD ND+ P F   +Y+ +
Sbjct: 2545 RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604

Query: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
            +  +   G  V+ V A+D D   NA+I Y  +E    S  E  EI+  SGVI T+  +  
Sbjct: 2605 IGSSAAKGTSVVKVLASDADEGSNADITY-AIEADSESVKENLEINKLSGVITTKESLIG 2663

Query: 358  EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
             E E +   V A D G     + +   V++ +       P+FSE  Y   V EDV  G  
Sbjct: 2664 LENEFFTFFVRAVDNGSP--SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTE 2721

Query: 418  VLRVTASDRDKGSNAVVHYSIMSGNA-----RGQFYLDAQTGALDVVSPLDYETTKEYTL 472
            +  + A       +  V YS++ GN         F +D Q+G L +   LD+ETTK Y  
Sbjct: 2722 IDLIRAE-----HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF 2776

Query: 473  RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
             + A+          S  V++QV D NDN+P+F S+P++A ++E++P G  V+ ++A DA
Sbjct: 2777 SILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDA 2836

Query: 533  DAGDNARLEYRL---AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTP- 588
            D+G N ++ Y L     V     F IN  TGWI+   ELD E+ D Y   V A DHG   
Sbjct: 2837 DSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKI 2896

Query: 589  ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV---ITY 645
             L+++A V VTV DVND+ P FT   Y   ++ED   G  +  +S  D D+  +   +TY
Sbjct: 2897 QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTY 2956

Query: 646  QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDA 705
             IT G+   +F++ +      V +  PLD +    Y+L +TA+DGT    A + V V DA
Sbjct: 2957 FITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDA 3016

Query: 706  NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMEDSIPQFRIDADT 764
            N + PV + + Y+  + ED   G  ++ ISATD D   NA ITY  +     +F+++ DT
Sbjct: 3017 NDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDT 3076

Query: 765  GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
            G + T   LD E+Q  Y L + A D G   +     + + + DVNDNAP+F  D Y  +V
Sbjct: 3077 GELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITV 3134

Query: 825  YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENV 884
            +E+  P T + ++ ATD D+GLN ++ Y+    D  DG F +   SGI++  + LDRE  
Sbjct: 3135 FENTEPGTLLTRVQATDADAGLNRKILYSLI--DSADGQFSINELSGIIQLEKPLDRELQ 3192

Query: 885  AQYVLRAYAVDKGMPPARTPM-EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
            A Y L   AVD+G+P   T    V V+VLD+NDNPPVFE  E+   V E+  +G  V +V
Sbjct: 3193 AVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQV 3252

Query: 944  TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---S 1000
             A   D   NA+I Y I+ GN    F +D  +G +  + +LDYE   EY L ++AT   +
Sbjct: 3253 YAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGT 3312

Query: 1001 APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRS-SSFPGGAIGRVPAHDPD--IS 1057
              L   ATV+V + D NDN PV        + Y T  S  +    ++  V A D D   +
Sbjct: 3313 PSLSDVATVNVNVTDINDNTPVFSQ-----DTYTTVISEDAVLEQSVITVMADDADGPSN 3367

Query: 1058 DSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
              + YS   GN+ S   ++   GE+K+++ LD        ++V  SD
Sbjct: 3368 SHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414



 Score =  428 bits (1101), Expect = e-119
 Identities = 314/973 (32%), Positives = 476/973 (48%), Gaps = 62/973 (6%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F PP+Y+  V E+ P GT +  L A DPD G++G++ Y++  L     N  F +D ++
Sbjct: 925  PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL--LDHGEGN--FDVDKLS 980

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTND--HDPVFEQQEYK 295
            GAV   ++LD E K  +   V A+D G P   S+   + + V D N+  H PVF     K
Sbjct: 981  GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
             +++E+  VG  V+TV A D DA  +  I Y + +GSG     VF+I   +GVI T   +
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG---VFKIGEETGVIETSDRL 1097

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            DRE    Y LTV A+DQG    P S+   +++ VED NDNAPQ SE  Y  ++ E+    
Sbjct: 1098 DRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS-PLDYETTKEYTLRV 474
              V+++ A D D  SN  + Y I SGN +G F +  +TG +   S  LD E   E+ L V
Sbjct: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEV 1215

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE-----------SVPLGYL 523
               D G PP S ++ ++ V++LD NDN P F+   ++  + E             PL   
Sbjct: 1216 TVTDNGSPPKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPL--- 1271

Query: 524  VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
              HV A D D G NA + Y +        F I   TG +S        E D  S  ++A 
Sbjct: 1272 -YHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILS--IKAV 1328

Query: 584  DHGTPALTASASVSVTVLDVNDNN---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH 640
            D+G P  +++  + +  +     +    +F +  +T  + E   V   +  +S       
Sbjct: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV--EPPG 1386

Query: 641  SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVV 700
              + + IT GN  + F +    G G + +A PLD + +  Y L V A+DGT     Q+ +
Sbjct: 1387 IPLWFDITGGNYDSHFDV--DKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFI 1444

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-----SI 755
             V D N HRP F +S Y V + ED    T ++ ISA D+D  E  ++ Y ++      S+
Sbjct: 1445 KVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSL 1502

Query: 756  PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
             +FR+D  TG++ T  +LD+E    +TL +  RD  +P K +   + + V+D ND+AP F
Sbjct: 1503 KKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWF 1562

Query: 816  LRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
               SY+G VYE     + VLQ++A D+D G N  V Y+ + G+ G+  F+++   G ++T
Sbjct: 1563 TASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMIDPVLGSIKT 1621

Query: 876  LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
             + LDR N A+Y L   A DKG PP      V + V   ++  P F   E+ V + E   
Sbjct: 1622 AKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVS 1681

Query: 936  IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
            IG  V  VTA      + + ++Y+I +GN  + F ++  SG +     LD+E  P Y L+
Sbjct: 1682 IGSFVGMVTA-----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLI 1736

Query: 996  IQATS-APLVSRATVHVRLLDRNDNPPVLGNFEI-------LFNNYVTNRSSSFPGGAIG 1047
            IQ T+ A L +  TV V L D NDN PV    E           N V     + P   + 
Sbjct: 1737 IQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVP--LVI 1794

Query: 1048 RVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GV 1106
            R    D D +  L Y     +  +   +++STG +    +LD         +V V D G 
Sbjct: 1795 RAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGT 1854

Query: 1107 HSVTAQCALRVTI 1119
              + A+ A  VT+
Sbjct: 1855 PRLFAEYAANVTV 1867



 Score =  390 bits (1001), Expect = e-107
 Identities = 293/953 (30%), Positives = 467/953 (49%), Gaps = 48/953 (5%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS-NQFFSL 234
            + APQF+   Y+  +  +   GT V  + A D DEG    + Y ++A  DS S  +   +
Sbjct: 2591 DNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA--DSESVKENLEI 2648

Query: 235  DPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            + ++G +TT E L         F V A D+G P + ++  + + +       P F +  Y
Sbjct: 2649 NKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFY 2708

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG--GSPSEVFEIDPRSGVIRTR 352
              ++ E++ +G E+  +RA       +  +LY L++G+    +  E F ID +SG ++  
Sbjct: 2709 TFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE 2763

Query: 353  GPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
              +D E  + YQ ++ A    +D      +  V + V+D NDN+P F    Y   + E++
Sbjct: 2764 KSLDHETTKWYQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENL 2822

Query: 413  TPGAPVLRVTASDRDKGSNAVVHYSI---MSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
              G+ V+++ ASD D G+N  V YS+    S      F ++ +TG +  +  LD+E    
Sbjct: 2823 PGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDN 2882

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            Y ++V A D G     + + +V V V D+ND+ P F +  ++ TV E  P G ++  +  
Sbjct: 2883 YQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILST 2942

Query: 530  IDADAGD-NARLEYRLAG---VGHDFPFTINNGTGW-ISVAAELDREEVDFYSFGVEARD 584
             DAD+ + N ++ Y + G   +G     TI N   W + V   LDRE+ D Y   + A D
Sbjct: 2943 TDADSEEINRQVTYFITGGDPLGQFAVETIQNE--WKVYVKKPLDREKRDNYLLTITATD 3000

Query: 585  HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--V 642
             GT   ++ A V V VLD NDN+P   +  Y+  + ED   G  ++ +SA D D  S   
Sbjct: 3001 -GT--FSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAE 3057

Query: 643  ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT-RQDTAQIVVN 701
            ITY +  G+   +F +   +G   +  + PLD + +  Y L V A+DG  R   A IV+ 
Sbjct: 3058 ITYTLL-GSGAEKFKLNPDTGE--LKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLT 3114

Query: 702  VTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRI 760
            + D N + P F +  Y + V E+   GT +  + ATD D G N +I Y + DS   QF I
Sbjct: 3115 LEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSI 3174

Query: 761  DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL-VNDVNDNAPQFLRDS 819
            +  +G +  +  LD E Q  YTL++ A D G+P++   T   I+ V D+NDN P F    
Sbjct: 3175 NELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYRE 3234

Query: 820  YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
            Y  +V ED+   T VLQ+ A  RD   N  + Y+   G++  G F ++S +G V  +  L
Sbjct: 3235 YGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE-HGKFSIDSKTGAVFIIENL 3293

Query: 880  DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            D E+  +Y L   A D G P       V V V D+NDN PVF QD +   + E++ +  +
Sbjct: 3294 DYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQS 3353

Query: 940  VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
            V  V A D D  +N+ I Y I++GN    F +D   GE+     LD E    Y L +QA+
Sbjct: 3354 VITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQAS 3413

Query: 1000 ---SAPLVSRATVHVRLLDRNDNPPVL--GNFEILFNNYVTNRSSSFPGGAIGRVPAHDP 1054
               S P V+  TV++ + D NDN PV   GN+ ++      N+   F   ++ ++   D 
Sbjct: 3414 DNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQE---NKPVGF---SVLQLVVTDE 3467

Query: 1055 DISDS---LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            D S +     ++   GN+     +N   G L  S A+        ++ V V+D
Sbjct: 3468 DSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVAD 3519



 Score =  385 bits (988), Expect = e-106
 Identities = 319/1030 (30%), Positives = 483/1030 (46%), Gaps = 92/1030 (8%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+F   +Y+A   EN P GT V SL A+DPDEGE G + Y++  L    ++  F++D  T
Sbjct: 461  PEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANL----NHVPFAIDHFT 516

Query: 239  GAVTTAEELDRETKS-THVFRVTAQDHGMPRRSALATL-TILVTDTNDHDPVFEQQEYKE 296
            GAV+T+E LD E     +  R+ A D G+P R  +  L TI + + ND+ P+FE+   + 
Sbjct: 517  GAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEG 576

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT-RGPV 355
            ++  +L VG ++ TV A D D      ++   +E   G+  + F ++P SGV+   R  +
Sbjct: 577  TIPRDLGVGEQITTVSAIDAD---ELQLVQYQIEA--GNELDFFSLNPNSGVLSLKRSLM 631

Query: 356  DR--EEVESYQLTVEASDQGRDPGP---RSTTAA-------------------------- 384
            D    +V  + L + A+D      P     T AA                          
Sbjct: 632  DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691

Query: 385  ----------VFLSVEDDNDNAPQF-SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
                      +F      N + PQF S     +QV+E+   G+ V+ + ++D D G N  
Sbjct: 692  KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751

Query: 434  VHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTV 493
            + Y++  GN    F +D +TG L ++SPLD ETT +YTL +   D G P  +    L+ V
Sbjct: 752  LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA-AWRLLHV 810

Query: 494  QVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
             V+D NDN P F+   +   V E   +   ++ V+A D D G N  + Y +  V     F
Sbjct: 811  VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI--VTDTDTF 868

Query: 554  TINNGTGWISVAAELDREEVDFYSFGVEARDHGT--PALTASASVSVTVLDVNDNNPTFT 611
            +I++ TG +++A  LDRE    +S  +EARD     P L ++  V V++ DVNDN PTF 
Sbjct: 869  SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928

Query: 612  QPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSL 669
             P Y V++ ED   GT ++ + A D D      + Y +      N F +   SG   V +
Sbjct: 929  PPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGA--VRI 985

Query: 670  ALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT--HRPVFQSSHYTVNVNE 723
               LD++ ++ Y L V A D  +      T  + V V D N   H PVF S      V E
Sbjct: 986  VQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKE 1045

Query: 724  DRPAGTTVVLISATDEDTGENARITYFMEDS--IPQFRIDADTGAVTTQAELDYEDQVSY 781
            D P G+ V+ +SA DED   +  I Y + D   +  F+I  +TG + T   LD E    Y
Sbjct: 1046 DAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHY 1105

Query: 782  TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
             L + A D G+   S    + I V DVNDNAPQ     Y   + E+ P   SV+QI A D
Sbjct: 1106 WLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFD 1165

Query: 842  RDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVAQYVLRAYAVDKGMPP 900
             DS  N ++ Y    G+   G F +   +G++ T  R+LDRE   +++L     D G PP
Sbjct: 1166 PDSSSNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP 1224

Query: 901  ARTPMEVTVTVLDVNDNPPVFEQDEFDV-FVEENSPIGLAVAR------VTATDPDEGTN 953
              T   V V +LD NDN P F Q  + +   E   P     AR      V ATD DEG N
Sbjct: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY-VLVIQA--TSAPLVSRAT-V 1009
            A+I Y I +GN    F ++  +G +++     +    EY +L I+A     P  S  T +
Sbjct: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSS---KRFSAAGEYDILSIKAVDNGRPQKSSTTRL 1341

Query: 1010 HVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNE 1069
            H+  + +        +FE  F  +    S       IG +    P I   L +    GN 
Sbjct: 1342 HIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGI--PLWFDITGGNY 1398

Query: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSI 1129
             S   ++  TG + +++ LD  +     ++V  +DG  ++  Q  ++V I T++      
Sbjct: 1399 DSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKV-IDTNDHRPQFS 1457

Query: 1130 TLRLEDMSPE 1139
            T + E + PE
Sbjct: 1458 TSKYEVVIPE 1467



 Score =  384 bits (987), Expect = e-106
 Identities = 298/1011 (29%), Positives = 498/1011 (49%), Gaps = 72/1011 (7%)

Query: 184  PSYQATVP------ENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            P +++T+P      ENQP G+ V  + + D D G  G+L Y   A+     +  F +D  
Sbjct: 714  PQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY---AVSGGNEDSCFMIDME 770

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
            TG +     LDRET   +   +T  D G+P+++A   L ++V D ND+ P F Q+ Y   
Sbjct: 771  TGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVE 830

Query: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
            + E+ EV  E++ V ATD D  PN ++ Y ++     + ++ F ID  +GV+    P+DR
Sbjct: 831  VSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDR 885

Query: 358  EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
            E    + L +EA DQ R+     +T  V +S+ED NDN P F    Y V+VRED+  G  
Sbjct: 886  ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTV 945

Query: 418  VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
            ++ + A D D G +  V YS++  +  G F +D  +GA+ +V  LD+E  + Y L VRA+
Sbjct: 946  IMWLEAHDPDLGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004

Query: 478  DGGRPPLSNVSGLVTVQVLDINDN--APIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
            D G+P   + +  V V+V+D+N+N   P+F S   + TV E  P+G LV+ V A D DA 
Sbjct: 1005 DKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064

Query: 536  DNARLEYRL---AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
             +  + Y +   +GVG    F I   TG I  +  LDRE    Y   V A D G   L++
Sbjct: 1065 RDGEIRYSIRDGSGVG---VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSS 1121

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITSG 650
               + + V DVNDN P  ++P Y   + E++    SVV + A D D+ S   + Y+ITSG
Sbjct: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181

Query: 651  NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANT 707
            N +  FSI  ++ G + + +  LD + + +++L VT +D     +   A+++V + D N 
Sbjct: 1182 NPQGFFSIHPKT-GLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240

Query: 708  HRPVFQSSHYTVNVNE----DRPAGT---TVVLISATDEDTGENARITYFMEDSIP--QF 758
            ++P F    Y + + E    DR        +  + ATD+D G NA I+Y +ED     +F
Sbjct: 1241 NKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKF 1300

Query: 759  RIDADTGAVTTQ---AELDYEDQVSYTLAITARDNGIPQKSDTT--YLEILVNDVNDNAP 813
             I+  TG V+++   A  +Y+      L+I A DNG PQKS TT  ++E +        P
Sbjct: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355

Query: 814  QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
                +S+      +  P   ++ + + +   G+   +++   GG + D  F V+  +G +
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVE-PPGI--PLWFDITGG-NYDSHFDVDKGTGTI 1411

Query: 874  RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
               + LD E  + Y L   A D G     T  +V + V+D ND+ P F   +++V + E+
Sbjct: 1412 IVAKPLDAEQKSNYNLTVEATD-GTTTILT--QVFIKVIDTNDHRPQFSTSKYEVVIPED 1468

Query: 934  SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRP 990
            +     + +++A D DE    +++Y +     P   + F+LD  +G L     LD+E   
Sbjct: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526

Query: 991  EYVLVIQATSAPLVSR---ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIG 1047
            ++ L +      +  +   A + V + D ND+ P           Y     S+  G  + 
Sbjct: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVY----ESAAVGSVVL 1582

Query: 1048 RVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD- 1104
            +V A D D   +  + YS E GN  +  +++   G +K ++ LD +   E  + V  +D 
Sbjct: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642

Query: 1105 GVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAA 1155
            G   ++   ++R+ +   +  +   T +  + S E   +  +G F+  V A
Sbjct: 1643 GSPPMSEITSVRIFVTIADNASPKFTSK--EYSVELSETVSIGSFVGMVTA 1691



 Score =  373 bits (958), Expect = e-102
 Identities = 302/950 (31%), Positives = 476/950 (50%), Gaps = 61/950 (6%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F   SY  T+ E    GT V  +RA D D      + Y M     S+S+  F +D  T
Sbjct: 2281 PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFG-NHSKSHDHFHVDSST 2339

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
            G ++    LD E    H   V A D GMP  S+   +T+ VTD ND+ P+FEQQ Y+  +
Sbjct: 2340 GLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARI 2399

Query: 299  RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
             E+   G+ V  V+A D D+     + Y +L    G+  + F ID  +G+I T   + R 
Sbjct: 2400 SEHAPHGHFVTCVKAYDADSSDIDKLQYSIL---SGNDHKHFVIDSATGII-TLSNLHRH 2455

Query: 359  EVES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
             ++  Y L +  SD     G   ++  V ++V   N ++P F +  Y V++ E+      
Sbjct: 2456 ALKPFYSLNLSVSD-----GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTL 2510

Query: 418  VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR-- 475
            V+ V  +D D G    V Y I++  A+ +FY++ + G +  +  LD ET  E  + VR  
Sbjct: 2511 VMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLDRETPAEKVISVRLM 2569

Query: 476  AQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            A+D GG+     V+ ++T    D NDNAP F +T ++  +  S   G  V+ V A DAD 
Sbjct: 2570 AKDAGGKVAFCTVNVILT----DDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADE 2625

Query: 535  GDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
            G NA + Y +            IN  +G I+    L   E +F++F V A D+G+P+  +
Sbjct: 2626 GSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKES 2685

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNT 652
               V V +L      P F++P YT  ++ED  +GT +  + A   +    + Y +  GNT
Sbjct: 2686 VVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVLYSLVKGNT 2742

Query: 653  --RNR---FSITSQSGGGLVSLALPLDYKLERQYVLAV----TASDGTRQDTAQIVVNVT 703
               NR   F I  QS  G + L   LD++  + Y  ++    T  D     +  + + V 
Sbjct: 2743 PESNRDESFVIDRQS--GRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVK 2800

Query: 704  DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDS-----IPQF 758
            DAN + PVF+SS Y   + E+ P G+ V+ I A+D D+G N ++ Y ++ S     I  F
Sbjct: 2801 DANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESF 2860

Query: 759  RIDADTGAVTTQAELDYEDQVSYTLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLR 817
             I+ +TG +TT  ELD+E + +Y + + A D+G   Q S T  +++ V DVND+ P+F  
Sbjct: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920

Query: 818  DSYQGSVYEDVPPFTSVLQISATDRDS-GLNGRVFYTFQGGDDGDGDFIVESTSG--IVR 874
            + Y+G+V ED P    +  +S TD DS  +N +V Y   GGD   G F VE+      V 
Sbjct: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDP-LGQFAVETIQNEWKVY 2979

Query: 875  TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
              + LDRE    Y+L   A D G   ++  +E  V VLD NDN PV E+  +   + E+ 
Sbjct: 2980 VKKPLDREKRDNYLLTITATD-GTFSSKAIVE--VKVLDANDNSPVCEKTLYSDTIPEDV 3036

Query: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
              G  + +++ATD D  +NA+I Y ++ G+  E F+L+  +GEL     LD E++  Y L
Sbjct: 3037 LPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAVYHL 3095

Query: 995  VIQAT-SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAH 1052
            +++AT       +A++ + L D NDN P     E   + Y +T   ++ PG  + RV A 
Sbjct: 3096 LVRATDGGGRFCQASIVLTLEDVNDNAP-----EFSADPYAITVFENTEPGTLLTRVQAT 3150

Query: 1053 DPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
            D D  ++  + YS     +     +N  +G ++L + LD  R L+A+ ++
Sbjct: 3151 DADAGLNRKILYSLIDSAD-GQFSINELSGIIQLEKPLD--RELQAVYTL 3197



 Score =  373 bits (957), Expect = e-102
 Identities = 299/1016 (29%), Positives = 487/1016 (47%), Gaps = 78/1016 (7%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + AP F    Y A V  +   G  +  + A+D D G  G + Y +        ++ F + 
Sbjct: 2076 DNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL-----KEHHEHFQIG 2130

Query: 236  PVTGAVTTAEELDRET-KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            P+ G ++  ++ + +T    ++  V A+D G P  S  A + + +T  N   PVFE+  Y
Sbjct: 2131 PL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFS--AEVIVPITVMNKAMPVFEKPFY 2187

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
               + E+++V   V+ V+A   ++P    + Y + +   G P   F I+  +GVI    P
Sbjct: 2188 SAEIAESIQVHSPVVHVQA---NSPEGLKVFYSITD---GDPFSQFTINFNTGVINVIAP 2241

Query: 355  VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLS--VEDDNDNAPQFSEKRYVVQVREDV 412
            +D E   +Y+L++ A+D           A VF+   V+D NDN P F+++ Y V + E  
Sbjct: 2242 LDFEAHPAYKLSIRATD-----SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEAS 2296

Query: 413  TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARG--QFYLDAQTGALDVVSPLDYETTKEY 470
              G  V++V A+D D   N  + Y +   +++    F++D+ TG + ++  LDYE ++++
Sbjct: 2297 VIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQH 2356

Query: 471  TLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530
            T+ VRA DGG P LS+   +VTV V D+NDN P+F    ++A + E  P G+ V  V+A 
Sbjct: 2357 TIFVRAVDGGMPTLSS-DVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415

Query: 531  DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
            DAD+ D  +L+Y +        F I++ TG I+++         FYS  +   D      
Sbjct: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD---GVF 2472

Query: 591  TASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQIT 648
             +S  V VTV+  N ++P F Q EY V L E+A + T V+ V   D D+  +  +TY I 
Sbjct: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532

Query: 649  SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAV--TASD-GTRQDTAQIVVNVTDA 705
            +   ++RF I  +   G +     LD +   + V++V   A D G +     + V +TD 
Sbjct: 2533 NDFAKDRFYINER---GQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDD 2589

Query: 706  NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME---DSIPQ-FRID 761
            N + P F+++ Y VN+      GT+VV + A+D D G NA ITY +E   +S+ +   I+
Sbjct: 2590 NDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEIN 2649

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
              +G +TT+  L   +   +T  + A DNG P K     + + +       P+F    Y 
Sbjct: 2650 KLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYT 2709

Query: 822  GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD----DGDGDFIVESTSGIVRTLR 877
             +V EDVP  T +  I A       +G V Y+   G+    + D  F+++  SG ++  +
Sbjct: 2710 FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEK 2764

Query: 878  RLDRENVAQY----VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
             LD E    Y    + R    D  M  +   ++V++ V D NDN PVFE   ++ F+ EN
Sbjct: 2765 SLDHETTKWYQFSILARCTQDDHEMVAS---VDVSIQVKDANDNSPVFESSPYEAFIVEN 2821

Query: 934  SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV---FQLDIFSGELTALVDLDYEDRP 990
             P G  V ++ A+D D GTN Q+MY + +    EV   F +++ +G +T L +LD+E R 
Sbjct: 2822 LPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRD 2881

Query: 991  EYVLVIQAT----SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGA 1045
             Y + + A+       L S A V V + D ND+PP           Y    S   P GG 
Sbjct: 2882 NYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPP-----RFTAEIYKGTVSEDDPQGGV 2936

Query: 1046 IGRVPAHDPD---ISDSLTYSFERGNELSLVLLNASTGELK--LSRALDNNRPLEAIMSV 1100
            I  +   D D   I+  +TY    G+ L    +     E K  + + LD  +    ++++
Sbjct: 2937 IAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTI 2996

Query: 1101 LVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAAT 1156
              +DG  S  A   ++V    D       TL   D  PE  L    G  I  ++AT
Sbjct: 2997 TATDGTFSSKAIVEVKVLDANDNSPVCEKTL-YSDTIPEDVLP---GKLIMQISAT 3048



 Score =  369 bits (946), Expect = e-101
 Identities = 282/937 (30%), Positives = 443/937 (47%), Gaps = 56/937 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+F   SY   V E++   + +  + A D D G  G + Y++    D+     FS+D VT
Sbjct: 820  PEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSIDSVT 874

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVT--DTNDHDPVFEQQEYKE 296
            G V  A  LDRE +  H  ++ A+D         +T+ + V+  D ND+ P F    Y+ 
Sbjct: 875  GVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRV 934

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             +RE+L  G  ++ + A D D   +  + Y LL+   G+    F++D  SG +R    +D
Sbjct: 935  KVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN----FDVDKLSGAVRIVQQLD 990

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN--APQFSEKRYVVQVREDVTP 414
             E+ + Y LTV A D+G+ P   S+T  V + V D N+N   P FS       V+ED   
Sbjct: 991  FEKKQVYNLTVRAKDKGK-PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV 1049

Query: 415  GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
            G+ V+ V+A D D   +  + YSI  G+  G F +  +TG ++    LD E+T  Y L V
Sbjct: 1050 GSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
             A D G  PLS+    + ++V D+NDNAP      +   ++E+ P    V+ ++A D D+
Sbjct: 1110 FATDQGVVPLSSFIE-IYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDS 1168

Query: 535  GDNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPALTAS 593
              N +L Y++        F+I+  TG I+  + +LDRE+ D +   V   D+G+P  +  
Sbjct: 1169 SSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTI 1228

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRL-------NEDAAVGTSVVTVSAVDRD--AHSVIT 644
            A V V +LD NDN P F Q  Y +RL        E  A    +  V A D+D   ++ I+
Sbjct: 1229 ARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEIS 1288

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQY-VLAVTASD-GTRQDTAQIVVNV 702
            Y I  GN   +F I  ++G     +     +    +Y +L++ A D G  Q ++   +++
Sbjct: 1289 YSIEDGNEHGKFFIEPKTG-----VVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI 1343

Query: 703  TDANTHRP-----VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
               +  +P      F+ S +T  V E  P    + +IS           IT    DS   
Sbjct: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDS--H 1401

Query: 758  FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLR 817
            F +D  TG +     LD E + +Y L + A D      +  T + I V D ND+ PQF  
Sbjct: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFST 1458

Query: 818  DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDD--GDGDFIVESTSGIVRT 875
              Y+  + ED  P T +LQISA D+D     ++ YT Q   D      F ++  +G + T
Sbjct: 1459 SKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYT 1516

Query: 876  LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
              +LD E V Q+ L     D+ +P  R    + V V D ND+ P F    +   V E++ 
Sbjct: 1517 SEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576

Query: 936  IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
            +G  V +VTA D D+G NA+++Y I  GNI   F +D   G +    +LD  ++ EY L+
Sbjct: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636

Query: 996  IQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
            ++AT   S P+    +V + +   ++  P   + E       T    SF    +G V AH
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSF----VGMVTAH 1692

Query: 1053 DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
                  S+ Y  + GN      +N  +G +   +ALD
Sbjct: 1693 S---QSSVVYEIKDGNTGDAFDINPHSGTIITQKALD 1726



 Score =  349 bits (896), Expect = 2e-95
 Identities = 289/1003 (28%), Positives = 457/1003 (45%), Gaps = 113/1003 (11%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P SY  ++PEN    T +A + A D D G  G   Y+    F  R++ F ++ P +
Sbjct: 147  PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYS----FKDRTDMF-AIHPTS 201

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRR-----SALATLTILVTDTNDHDPVFEQQE 293
            G +     LD      +   + A D GM        S++A LT+ +   N+  PV     
Sbjct: 202  GVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANIL-YRLLEGSGGSPSEVFEIDPRSGVIRTR 352
               S  +  +  Y ++TV   D D   N +I    ++ G            P S   + +
Sbjct: 262  LSPSELDR-DPAYAIVTV--DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318

Query: 353  --GPVDREEVE-SYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
              G +D +     Y LT++A D+G  P   S+   + ++         +F +  Y  ++ 
Sbjct: 319  AIGGIDWDSHPFGYNLTLQAKDKGTPP-QFSSVKVIHVTSPQFKAGPVKFEKDVYRAEIS 377

Query: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
            E   P  PV+ V A      + + + Y   S   + +F L+  TG + ++ P+  +    
Sbjct: 378  EFAPPNTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH 433

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            + L V   D         S  V V+VL  N N P F  T ++A   E+VP+G  V+ + A
Sbjct: 434  FELEVTTSD------RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487

Query: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD-FYSFGVEARDHGTP 588
            +D D G+N  + Y +A + H  PF I++ TG +S +  LD E +   Y+  + A D G P
Sbjct: 488  VDPDEGENGYVTYSIANLNH-VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546

Query: 589  -ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQI 647
                     ++T+ ++NDN P F +      +  D  VG  + TVSA+D D   ++ YQI
Sbjct: 547  YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQI 606

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ---YVLAVTASDGTRQDTAQIVVNVTD 704
             +GN  + FS+   S  G++SL   L   L  +   + L +TA+DG    T  + +N+T 
Sbjct: 607  EAGNELDFFSLNPNS--GVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PLYINITV 663

Query: 705  A---------------------------------------------NTHRPVFQSSHYT- 718
            A                                             N H P F+S+  T 
Sbjct: 664  AASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTG 723

Query: 719  VNVNEDRPAGTTVVLISATDEDTGENARITYFM----EDSIPQFRIDADTGAVTTQAELD 774
            + V E++P G++V+ +++TD DTG N ++ Y +    EDS   F ID +TG +   + LD
Sbjct: 724  IQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC--FMIDMETGMLKILSPLD 781

Query: 775  YEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
             E    YTL IT  D GIPQK+    L ++V D NDN P+FL++SY   V ED    + +
Sbjct: 782  RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
            +Q+ ATD+D G NG V Y+     D    F ++S +G+V   R LDRE   ++ L+  A 
Sbjct: 842  IQVEATDKDLGPNGHVTYSIVTDTD---TFSIDSVTGVVNIARPLDRELQHEHSLKIEAR 898

Query: 895  DKGM--PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
            D+    P   + + V V++ DVNDNPP F    + V V E+ P G  +  + A DPD G 
Sbjct: 899  DQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ 958

Query: 953  NAQIMYQIV---EGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS----APLVS 1005
            + Q+ Y ++   EGN    F +D  SG +  +  LD+E +  Y L ++A        L S
Sbjct: 959  SGQVRYSLLDHGEGN----FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014

Query: 1006 RATVHVRLLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDI--SDSLT 1061
               V V ++D N+N  PPV  +F        T +  +  G  +  V AHD D      + 
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFV----EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIR 1070

Query: 1062 YSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            YS   G+ + +  +   TG ++ S  LD        ++V  +D
Sbjct: 1071 YSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD 1113



 Score =  347 bits (891), Expect = 8e-95
 Identities = 289/954 (30%), Positives = 448/954 (46%), Gaps = 58/954 (6%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F+   Y+A + E+ P G  V  ++A D D  +  +L+Y   ++     ++ F +D  T
Sbjct: 2388 PLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQY---SILSGNDHKHFVIDSAT 2444

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
            G +T +       K  +   ++  D G+ R S    +T++    N H P F Q EY+  L
Sbjct: 2445 GIITLSNLHRHALKPFYSLNLSVSD-GVFRSSTQVHVTVI--GGNLHSPAFLQNEYEVEL 2501

Query: 299  RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
             EN  +   V+ V+ TDGD+    ++ Y ++        + F I+ R G I T   +DRE
Sbjct: 2502 AENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA---KDRFYINER-GQIFTLEKLDRE 2557

Query: 359  EVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
                  ++V      +D G +     V + + DDNDNAPQF   +Y V +      G  V
Sbjct: 2558 TPAEKVISVRL--MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSV 2615

Query: 419  LRVTASDRDKGSNAVVHYSIM--SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
            ++V ASD D+GSNA + Y+I   S + +    ++  +G +     L     + +T  VRA
Sbjct: 2616 VKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRA 2675

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
             D G P   +V  LV V++L      P F    +  TV E VP+G  +  ++A  +    
Sbjct: 2676 VDNGSPSKESVV-LVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR----DHGTPALTA 592
             + ++        D  F I+  +G + +   LD E   +Y F + AR    DH    + A
Sbjct: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH---EMVA 2791

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY---QI 647
            S  VS+ V D NDN+P F    Y   + E+   G+ V+ + A D D+  +  + Y   Q 
Sbjct: 2792 SVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQS 2851

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ----DTAQIVVNVT 703
             S      F+I  ++  G ++    LD++    Y + V ASD   +     TA + V VT
Sbjct: 2852 QSVEVIESFAINMET--GWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909

Query: 704  DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFME--DSIPQFRI 760
            D N   P F +  Y   V+ED P G  + ++S TD D+ E N ++TYF+   D + QF +
Sbjct: 2910 DVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAV 2969

Query: 761  DA--DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRD 818
            +   +   V  +  LD E + +Y L ITA D     K+    +E+ V D NDN+P   + 
Sbjct: 2970 ETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKA---IVEVKVLDANDNSPVCEKT 3026

Query: 819  SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
             Y  ++ EDV P   ++QISATD D   N  + YT  G   G   F +   +G ++T   
Sbjct: 3027 LYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLG--SGAEKFKLNPDTGELKTSTP 3084

Query: 879  LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
            LDRE  A Y L   A D G    +    + +T+ DVNDN P F  D + + V EN+  G 
Sbjct: 3085 LDREEQAVYHLLVRATDGGGRFCQA--SIVLTLEDVNDNAPEFSADPYAITVFENTEPGT 3142

Query: 939  AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
             + RV ATD D G N +I+Y +++ +    F ++  SG +     LD E +  Y L ++A
Sbjct: 3143 LLTRVQATDADAGLNRKILYSLID-SADGQFSINELSGIIQLEKPLDRELQAVYTLSLKA 3201

Query: 999  TSAPLVSR----ATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHD 1053
                L  R     TV V +LD NDNPPV   FE  +  Y  T       G  + +V A  
Sbjct: 3202 VDQGLPRRLTATGTVIVSVLDINDNPPV---FE--YREYGATVSEDILVGTEVLQVYAAS 3256

Query: 1054 PDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
             DI  +  +TYS   GNE     +++ TG + +   LD     E  ++V  +DG
Sbjct: 3257 RDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDG 3310



 Score =  347 bits (891), Expect = 8e-95
 Identities = 249/741 (33%), Positives = 375/741 (50%), Gaps = 56/741 (7%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            ++ P+F    Y+ TV E+ P G  +A L   D D  E  R + T          QF +++
Sbjct: 2913 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINR-QVTYFITGGDPLGQF-AVE 2970

Query: 236  PVTGA--VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293
             +     V   + LDRE +  ++  +TA D      S+ A + + V D ND+ PV E+  
Sbjct: 2971 TIQNEWKVYVKKPLDREKRDNYLLTITATDGTF---SSKAIVEVKVLDANDNSPVCEKTL 3027

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            Y +++ E++  G  ++ + ATD D   NA I Y LL    GS +E F+++P +G ++T  
Sbjct: 3028 YSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL----GSGAEKFKLNPDTGELKTST 3083

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
            P+DREE   Y L V A+D G     R   A++ L++ED NDNAP+FS   Y + V E+  
Sbjct: 3084 PLDREEQAVYHLLVRATDGGG----RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTE 3139

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
            PG  + RV A+D D G N  + YS++  +A GQF ++  +G + +  PLD E    YTL 
Sbjct: 3140 PGTLLTRVQATDADAGLNRKILYSLID-SADGQFSINELSGIIQLEKPLDRELQAVYTLS 3198

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
            ++A D G P     +G V V VLDINDN P+F    + ATV E + +G  VL V A   D
Sbjct: 3199 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD 3258

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
               NA + Y +        F+I++ TG + +   LD E    Y   VEA D GTP+L+  
Sbjct: 3259 IEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDV 3318

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
            A+V+V V D+NDN P F+Q  YT  ++EDA +  SV+TV A D D  ++S I Y I  GN
Sbjct: 3319 ATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGN 3378

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
              + F+I    G   V +   LD +    Y L V ASD     R +T  + ++V+D N +
Sbjct: 3379 QGSSFTIDPVRGE--VKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDN 3436

Query: 709  RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRIDADTG 765
             PVF   +Y+V + E++P G +V+ +  TDED+  N    +F     +    F ++   G
Sbjct: 3437 APVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-G 3495

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL--------- 816
             + T + +  +++  Y L +   DNG PQ S  TY++I V + +   P  L         
Sbjct: 3496 VLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSS 3555

Query: 817  RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD--FIVESTSGIVR 874
             + Y G V         + +I ATD+D      V+ T     D   D  F V ST G + 
Sbjct: 3556 GEEYSGGV---------IGKIHATDQD------VYDTLTYSLDPQMDNLFSVSSTGGKLI 3600

Query: 875  TLRRLDRENVAQYVLRAYAVD 895
              ++LD   + QY+L     D
Sbjct: 3601 AHKKLD---IGQYLLNVSVTD 3618



 Score =  332 bits (851), Expect = 3e-90
 Identities = 278/1020 (27%), Positives = 461/1020 (45%), Gaps = 99/1020 (9%)

Query: 174  NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
            N NT P F+  + + T+P +   G  + ++ AID DE +   ++Y ++A        FFS
Sbjct: 563  NDNT-PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEA---GNELDFFS 616

Query: 234  LDPVTGAVTTAEELD---RETKSTHVFRVTAQDHGMPRRSALATLTILVT---------- 280
            L+P +G ++    L        S H  R+TA D           +T+  +          
Sbjct: 617  LNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEE 676

Query: 281  -------------------------------DTNDHDPVFEQQ-EYKESLRENLEVGYEV 308
                                             N H P F         ++EN  VG  V
Sbjct: 677  TGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV 736

Query: 309  LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
            + + +TD D   N  ++Y +   SGG+    F ID  +G+++   P+DRE  + Y L + 
Sbjct: 737  IFMNSTDLDTGFNGKLVYAV---SGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNIT 793

Query: 369  ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428
              D G     ++    + + V D NDN P+F ++ Y V+V ED    + +++V A+D+D 
Sbjct: 794  VYDLGIP--QKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDL 851

Query: 429  GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGR-PPLSNV 487
            G N  V YSI++      F +D+ TG +++  PLD E   E++L++ A+D  R  P    
Sbjct: 852  GPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFS 909

Query: 488  SGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            + +V V + D+NDN P F+   ++  V E +P G +++ ++A D D G + ++ Y L   
Sbjct: 910  TVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDH 969

Query: 548  GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTP-ALTASASVSVTVLDVNDN 606
            G +  F ++  +G + +  +LD E+   Y+  V A+D G P +L+++  V V V+DVN+N
Sbjct: 970  G-EGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNEN 1028

Query: 607  --NPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH--SVITYQITSGNTRNRFSITSQS 662
               P F+       + EDA VG+ V+TVSA D DA     I Y I  G+    F I  ++
Sbjct: 1029 LHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEET 1088

Query: 663  GGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTV 719
              G++  +  LD +    Y L V A+D          +I + V D N + P      Y  
Sbjct: 1089 --GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYP 1146

Query: 720  NVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQA-ELDYE 776
             + E+ P   +VV I A D D+  N ++ Y +    PQ  F I   TG +TT + +LD E
Sbjct: 1147 EIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE 1206

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS--- 833
             Q  + L +T  DNG P KS    + + + D NDN PQFL+  Y+  + E   P      
Sbjct: 1207 QQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNA 1266

Query: 834  ----VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY-V 888
                +  + ATD+D G N  + Y+ + G++  G F +E  +G+V + R        +Y +
Sbjct: 1267 RREPLYHVIATDKDEGPNAEISYSIEDGNE-HGKFFIEPKTGVVSSKR---FSAAGEYDI 1322

Query: 889  LRAYAVDKGMPPARTPMEVTVTVLD---VNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
            L   AVD G P   +   + +  +     +  P  FE+  F   V E+ P+   +  ++ 
Sbjct: 1323 LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV 1382

Query: 946  TDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVS 1005
              P       + + I  GN    F +D  +G +     LD E +  Y L ++AT      
Sbjct: 1383 EPP----GIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI 1438

Query: 1006 RATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFE 1065
               V ++++D ND+ P     +      V     + P   I ++ A D D  + L Y+ +
Sbjct: 1439 LTQVFIKVIDTNDHRPQFSTSKY----EVVIPEDTAPETEILQISAVDQDEKNKLIYTLQ 1494

Query: 1066 RGNE---LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
               +   L    L+ +TG L  S  LD+    +  ++V+V D    V    A  V  ++D
Sbjct: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554



 Score =  320 bits (820), Expect = 1e-86
 Identities = 273/990 (27%), Positives = 447/990 (45%), Gaps = 69/990 (6%)

Query: 180  QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
            +F    Y A V EN      +A + AI     E   L Y +        ++ F +   +G
Sbjct: 1978 KFTQDVYSAVVKENSTEAETLAVITAIGNPINEP--LFYHI-----LNPDRRFKISRTSG 2030

Query: 240  AV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
             + TT    DRE +      V   +   P   A   + ++V D ND+ PVF    Y   +
Sbjct: 2031 VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVV 2090

Query: 299  RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV-IRTRGPVDR 357
            + + EVG+ +  V A D D+  N  + Y L E       E F+I P   + ++ +  +D 
Sbjct: 2091 KVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH-----EHFQIGPLGEISLKKQFELDT 2145

Query: 358  EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
               E Y +TV A D G      + +A V + +   N   P F +  Y  ++ E +   +P
Sbjct: 2146 LNKE-YLVTVVAKDGGNP----AFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP 2200

Query: 418  VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
            V+ V A+  +      V YSI  G+   QF ++  TG ++V++PLD+E    Y L +RA 
Sbjct: 2201 VVHVQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT 2257

Query: 478  DGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDN 537
            D      + V   V + V DINDN P+F    +  T+ E+  +G  V+ V+A D+D+  N
Sbjct: 2258 DSLTGAHAEV--FVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPN 2315

Query: 538  ARLEYRLAG---VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
              + Y++ G     HD  F +++ TG IS+   LD E+   ++  V A D G P L++  
Sbjct: 2316 RGISYQMFGNHSKSHDH-FHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDV 2374

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV--ITYQITSGNT 652
             V+V V D+NDN P F Q  Y  R++E A  G  V  V A D D+  +  + Y I SGN 
Sbjct: 2375 IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND 2434

Query: 653  RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVF 712
               F I S +  G+++L+    + L+  Y L ++ SDG  + + Q+ V V   N H P F
Sbjct: 2435 HKHFVIDSAT--GIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAF 2492

Query: 713  QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA-DTGAVTTQA 771
              + Y V + E+ P  T V+ +  TD D+G    +TY + +   + R    + G + T  
Sbjct: 2493 LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLE 2552

Query: 772  ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPF 831
            +LD E      +++         K     + +++ D NDNAPQF    Y+ ++       
Sbjct: 2553 KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKG 2612

Query: 832  TSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI-VESTSGIVRTLRRLDRENVAQYVLR 890
            TSV+++ A+D D G N  + Y  +   +   + + +   SG++ T   L       +   
Sbjct: 2613 TSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFF 2672

Query: 891  AYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDE 950
              AVD G P   + + V V +L      P F +  +   V E+ PIG  +  + A     
Sbjct: 2673 VRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH--- 2729

Query: 951  GTNAQIMYQIVEGNIP-----EVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---- 1001
              +  ++Y +V+GN P     E F +D  SG L     LD+E    Y   I A       
Sbjct: 2730 --SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH 2787

Query: 1002 PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA-IGRVPAHDPD--ISD 1058
             +V+   V +++ D NDN PV  +     + Y      + PGG+ + ++ A D D   + 
Sbjct: 2788 EMVASVDVSIQVKDANDNSPVFES-----SPYEAFIVENLPGGSRVIQIRASDADSGTNG 2842

Query: 1059 SLTYSFERGNELSLV---LLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCAL 1115
             + YS ++   + ++    +N  TG +   + LD+ +     + V+ SD  H    Q  L
Sbjct: 2843 QVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASD--HGEKIQ--L 2898

Query: 1116 RVTIITDEMLTHSITLRLEDMSPERFLSPL 1145
              T I D      +T+   + SP RF + +
Sbjct: 2899 SSTAIVD------VTVTDVNDSPPRFTAEI 2922



 Score =  315 bits (806), Expect = 5e-85
 Identities = 257/873 (29%), Positives = 401/873 (45%), Gaps = 60/873 (6%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + APQ   P Y   + EN P    V  + A DPD     +L Y + +        FFS+ 
Sbjct: 1134 DNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITS---GNPQGFFSIH 1190

Query: 236  PVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            P TG + TT+ +LDRE +  H+  VT  D+G P +S +A + + + D ND+ P F Q+ Y
Sbjct: 1191 PKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFY 1250

Query: 295  KESLRENLEVGYE-------VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
            K  L E  +   E       +  V ATD D  PNA I Y + +G+       F I+P++G
Sbjct: 1251 KIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGK---FFIEPKTG 1307

Query: 348  VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTA--AVFLSVEDDNDNAPQFSEKRYV 405
            V+ ++      E +   L+++A D GR P   STT     ++S    +     F E  + 
Sbjct: 1308 VVSSKRFSAAGEYDI--LSIKAVDNGR-PQKSSTTRLHIEWISKPKPSLEPISFEESFFT 1364

Query: 406  VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYE 465
              V E      PV  +      +     + + I  GN    F +D  TG + V  PLD E
Sbjct: 1365 FTVME----SDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE 1420

Query: 466  TTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
                Y L V A DG    L+     V ++V+D ND+ P F ++ ++  + E       +L
Sbjct: 1421 QKSNYNLTVEATDGTTTILTQ----VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEIL 1476

Query: 526  HVQAIDADAGDNARLEYRLAGVGHDF---PFTINNGTGWISVAAELDREEVDFYSFGVEA 582
             + A+D D  +  +L Y L           F ++  TG +  + +LD E V  ++  V  
Sbjct: 1477 QISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534

Query: 583  RDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AH 640
            RD   P     A + V V D ND+ P FT   Y  R+ E AAVG+ V+ V+A+D+D   +
Sbjct: 1535 RDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKN 1594

Query: 641  SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIV- 699
            + + Y I SGN  N F I    G   +  A  LD   + +Y L V A+D      ++I  
Sbjct: 1595 AEVLYSIESGNIGNSFMIDPVLGS--IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITS 1652

Query: 700  --VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED--SI 755
              + VT A+   P F S  Y+V ++E    G+ V +++A  + +     + Y ++D  + 
Sbjct: 1653 VRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTG 1707

Query: 756  PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
              F I+  +G + TQ  LD+E    YTL I  +   +   S  T + + + D NDNAP F
Sbjct: 1708 DAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLVHLQDENDNAPVF 1765

Query: 816  LRDSYQGSVYEDVPPFTSVLQ-------ISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
            ++  Y G + E     + VL        I A D D   N  + Y           F ++S
Sbjct: 1766 MQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIV-EPSVHTYFAIDS 1824

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP--ARTPMEVTVTVLDVNDNPPVFEQDEF 926
            ++G + T+  LD E  + +       D G P   A     VTV V+D+ND PPVF +  +
Sbjct: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
            +  +   +  G+ V  V ATD D    +Q++Y I EGNI E F +D  +G LT  V    
Sbjct: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT--VQNTT 1942

Query: 987  EDRPEYVLVIQATSAPLVSRATVHVRLLDRNDN 1019
            + R  Y L ++A+        +V + + +  ++
Sbjct: 1943 QLRSRYELTVRASDGRFAGLTSVKINVKESKES 1975



 Score =  303 bits (776), Expect = 2e-81
 Identities = 268/984 (27%), Positives = 454/984 (46%), Gaps = 85/984 (8%)

Query: 179  PQFQPPSYQATVPENQPAGT-------PVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF 231
            PQF    Y+  +PE +           P+  + A D DEG    + Y+++   D   +  
Sbjct: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE---DGNEHGK 1299

Query: 232  FSLDPVTGAVTT-----AEELDRETKSTHVFRVTAQDHGMPRRSALATLTI--LVTDTND 284
            F ++P TG V++     A E D       +  + A D+G P++S+   L I  +      
Sbjct: 1300 FFIEPKTGVVSSKRFSAAGEYD-------ILSIKAVDNGRPQKSSTTRLHIEWISKPKPS 1352

Query: 285  HDPV-FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEID 343
             +P+ FE+  +  ++ E+  V + +  +       PP   + + +   +GG+    F++D
Sbjct: 1353 LEPISFEESFFTFTVMESDPVAHMIGVISVE----PPGIPLWFDI---TGGNYDSHFDVD 1405

Query: 344  PRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKR 403
              +G I    P+D E+  +Y LTVEA+D     G  +    VF+ V D ND+ PQFS  +
Sbjct: 1406 KGTGTIIVAKPLDAEQKSNYNLTVEATD-----GTTTILTQVFIKVIDTNDHRPQFSTSK 1460

Query: 404  YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVS 460
            Y V + ED  P   +L+++A D+D+ +  +  Y++ S     +  +F LD  TG+L    
Sbjct: 1461 YEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSSRDPLSLKKFRLDPATGSLYTSE 1518

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
             LD+E   ++TL V  +D   P   N + +V V V D ND+AP F ++ ++  V ES  +
Sbjct: 1519 KLDHEAVHQHTLTVMVRDQDVPVKRNFARIV-VNVSDTNDHAPWFTASSYKGRVYESAAV 1577

Query: 521  GYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGV 580
            G +VL V A+D D G NA + Y +        F I+   G I  A ELDR     Y   V
Sbjct: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637

Query: 581  EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH 640
            +A D G+P ++   SV + V   ++ +P FT  EY+V L+E  ++G+ V  V+A    + 
Sbjct: 1638 KATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA---HSQ 1694

Query: 641  SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIV 699
            S + Y+I  GNT + F I   SG  +   A  LD++    Y L +  ++     T   ++
Sbjct: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKA--LDFETLPIYTLIIQGTNMAGLSTNTTVL 1752

Query: 700  VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTV-------VLISATDEDTGENARITY-FM 751
            V++ D N + PVF  + YT  ++E     + V       ++I A D D   NA + Y  +
Sbjct: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIV 1812

Query: 752  EDSI-PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQ--KSDTTYLEILVNDV 808
            E S+   F ID+ TGA+ T   LDYE+   +   +   D G P+        + + V D+
Sbjct: 1813 EPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872

Query: 809  NDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
            ND  P F +  Y+ S+         V+ ++ATD DS    ++ Y+   G+ G+  F ++ 
Sbjct: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGE-KFSMDY 1931

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
             +G +         +  +  +RA     G     T   V + V +  ++   F QD +  
Sbjct: 1932 KTGALTVQNTTQLRSRYELTVRA---SDGRFAGLT--SVKINVKESKESHLKFTQDVYSA 1986

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDLDYE 987
             V+ENS     +A +TA       N  + Y I+  N    F++   SG L T     D E
Sbjct: 1987 VVKENSTEAETLAVITAI--GNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDRE 2042

Query: 988  DRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG 1044
             +  + +V++ T       V+   V V + D+NDN PV  N       Y   +  +  G 
Sbjct: 2043 QQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY----YAVVKVDTEVGH 2098

Query: 1045 AIGRVPAHDPDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALD-NNRPLEAIMSVL 1101
             I  V A D D   +  + Y  +  +E   +      GE+ L +  + +    E +++V+
Sbjct: 2099 VIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI---GPLGEISLKKQFELDTLNKEYLVTVV 2155

Query: 1102 VSDGVH-SVTAQCALRVTIITDEM 1124
              DG + + +A+  + +T++   M
Sbjct: 2156 AKDGGNPAFSAEVIVPITVMNKAM 2179



 Score =  253 bits (646), Expect = 2e-66
 Identities = 237/880 (26%), Positives = 379/880 (43%), Gaps = 95/880 (10%)

Query: 247  LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
            L+RE K  +   V A +       A   + + V DTND  P+F    Y  SL EN  +  
Sbjct: 108  LNREVKDHYTLIVKALEKNT-NVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166

Query: 307  EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
             +  V ATD D   N    Y     S    +++F I P SGVI   G +D  E + Y++ 
Sbjct: 167  SIARVSATDADIGTNGEFYY-----SFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEME 221

Query: 367  VEASDQGR---DPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
            + A+D+G         S+ A + + +E  N+ AP  +    V     ++        VT 
Sbjct: 222  ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---VTLSPSELDRDPAYAIVTV 278

Query: 424  SDRDKGSNA-VVHYSIMSGNARGQF-----YLDAQTGALDVVSPLDYETTK-EYTLRVRA 476
             D D+G+N  +   SI++G+   QF     +  ++   +  +  +D+++    Y L ++A
Sbjct: 279  DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA 338

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
            +D G PP  +   ++ V           F    ++A + E  P    V+ V+AI A    
Sbjct: 339  KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA---- 394

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
             + L Y          F++N  TG IS+   + R++   +   V   D       AS  V
Sbjct: 395  YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKV 449

Query: 597  SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRN 654
             V VL  N N P FTQ  Y    +E+  +GT+V+++SAVD D   +  +TY I +    N
Sbjct: 450  LVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN---LN 506

Query: 655  RFSITSQSGGGLVSLALPLDYKL-ERQYVLAVTASDG----TRQDTAQIVVNVTDANTHR 709
                      G VS +  LDY+L  R Y L + ASD      R+      + + + N + 
Sbjct: 507  HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566

Query: 710  PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTT 769
            P+F+  +    +  D   G  +  +SA D D  +  +      + +  F ++ ++G ++ 
Sbjct: 567  PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626

Query: 770  QAEL--DYEDQVSY-TLAITARD------------------------------------- 789
            +  L      +VS+ +L ITA D                                     
Sbjct: 627  KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEK 686

Query: 790  ----NGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG-SVYEDVPPFTSVLQISATDRDS 844
                N +  + +   +    + VN + PQF      G  V E+ P  +SV+ +++TD D+
Sbjct: 687  LLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT 746

Query: 845  GLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTP 904
            G NG++ Y   GG++ D  F+++  +G+++ L  LDRE   +Y L     D G+P     
Sbjct: 747  GFNGKLVYAVSGGNE-DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAW 805

Query: 905  MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN 964
              + V V+D NDNPP F Q+ + V V E+  +   + +V ATD D G N  + Y IV   
Sbjct: 806  RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT 865

Query: 965  IPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA-----TSAPLVSRATVHVRLLDRNDN 1019
              + F +D  +G +     LD E + E+ L I+A         L S   V V L D NDN
Sbjct: 866  --DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923

Query: 1020 PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS 1059
            PP      I  N  V  R     G  I  + AHDPD+  S
Sbjct: 924  PPTF----IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQS 959



 Score =  177 bits (449), Expect = 1e-43
 Identities = 165/546 (30%), Positives = 250/546 (45%), Gaps = 44/546 (8%)

Query: 566  AELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV 625
            A L+RE  D Y+  V+A +  T  + A   V V VLD ND  P F+   Y+V L E+ A+
Sbjct: 106  AILNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAI 164

Query: 626  GTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAV 685
             TS+  VSA D D  +   +  +  +  + F+I   S  G++ L   LDY   + Y + +
Sbjct: 165  RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTS--GVIVLTGRLDYLETKLYEMEI 222

Query: 686  TASD-GTR-------QDTAQIVVNVTDANTHRPVFQSSHYTVNVNE-DRPAGTTVVLISA 736
             A+D G +          A++ V++  AN   PV  +   T++ +E DR     +V +  
Sbjct: 223  LAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--VTLSPSELDRDPAYAIVTVDD 280

Query: 737  TDED-TGENARITYFMEDSIPQFR-IDADTGA----VTTQAELDYEDQ-VSYTLAITARD 789
             D+   G+ A ++    D + QFR + +  G+    V     +D++     Y L + A+D
Sbjct: 281  CDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKD 340

Query: 790  NGI-PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNG 848
             G  PQ S    + +          +F +D Y+  + E  PP T V+ + A    S L  
Sbjct: 341  KGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLR- 399

Query: 849  RVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT 908
               Y F+    G   F +   +G++  L  + R+  A + L     D+     +   +V 
Sbjct: 400  ---YVFK-STPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVL 450

Query: 909  VTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN-IPE 967
            V VL  N NPP F Q  +    +EN PIG  V  ++A DPDEG N  + Y I   N +P 
Sbjct: 451  VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP- 509

Query: 968  VFQLDIFSGELTALVDLDYEDRPE-YVLVIQATSAPLVSRATVHV----RLLDRNDNPPV 1022
             F +D F+G ++   +LDYE  P  Y L I+A+   L  R  V V     L + NDN P+
Sbjct: 510  -FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPL 568

Query: 1023 LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGEL 1082
               FE + N   T       G  I  V A D D    + Y  E GNEL    LN ++G L
Sbjct: 569  ---FEKI-NCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVL 624

Query: 1083 KLSRAL 1088
             L R+L
Sbjct: 625  SLKRSL 630



 Score =  153 bits (387), Expect = 2e-36
 Identities = 195/769 (25%), Positives = 328/769 (42%), Gaps = 107/769 (13%)

Query: 434  VHYSIMSGNARGQF-----------YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
            V Y I+SG++   F           +L  +T   +    L+ E    YTL V+A +    
Sbjct: 70   VRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAI-LNREVKDHYTLIVKALEKN-- 126

Query: 483  PLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
              +NV     V VQVLD ND  P+F  T +  ++ E+  +   +  V A DAD G N   
Sbjct: 127  --TNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEF 184

Query: 541  EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD-----HGTPALTASAS 595
             Y          F I+  +G I +   LD  E   Y   + A D     +G+  +++ A 
Sbjct: 185  YYSFK--DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAK 242

Query: 596  VSVTVLDVNDNNPTFTQPEYT-VRLNEDAAVGTSVVTVSAVDRDAH-SVITYQITSGNTR 653
            ++V +   N+  P  T    +   L+ D A   ++VTV   D+ A+  + +  I +G+  
Sbjct: 243  LTVHIEQANECAPVITAVTLSPSELDRDPAY--AIVTVDDCDQGANGDIASLSIVAGDLL 300

Query: 654  NRF-SITSQSG---------GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQI-VVNV 702
             +F ++ S  G         GG+   + P  Y L  Q         GT    + + V++V
Sbjct: 301  QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQ-----AKDKGTPPQFSSVKVIHV 355

Query: 703  TDANTHR-PV-FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRI 760
            T       PV F+   Y   ++E  P  T VV++ A       + R  +       +F +
Sbjct: 356  TSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAI--PAYSHLRYVFKSTPGKAKFSL 413

Query: 761  DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
            + +TG ++    +  +    + L +T  D    +K+ T  L + V   N N P+F + +Y
Sbjct: 414  NYNTGLISILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAY 468

Query: 821  QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLD 880
            + +  E+VP  T+V+ +SA D D G NG V Y+    +     F ++  +G V T   LD
Sbjct: 469  KAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI--ANLNHVPFAIDHFTGAVSTSENLD 526

Query: 881  RENVAQ-YVLRAYAVDKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
             E + + Y LR  A D G+P  R   +  T+T+ ++NDN P+FE+   +  +  +  +G 
Sbjct: 527  YELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGE 586

Query: 939  AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVD------------ 983
             +  V+A D DE     + YQI  GN  + F L+  SG L+   +L+D            
Sbjct: 587  QITTVSAIDADE--LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644

Query: 984  ---LDYED--RPEYVLVIQATSAPLVSR-------ATVHVRLLDRNDNPPVLGNFEILF- 1030
                D E+   P Y+ +  A S  LV+        A +    L + +     G  E +F 
Sbjct: 645  ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFF 704

Query: 1031 -----NNYVTNRSSSFP-----------GGAIGRVPAHDPD--ISDSLTYSFERGNELSL 1072
                 N ++    S+ P           G ++  + + D D   +  L Y+   GNE S 
Sbjct: 705  DSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC 764

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
             +++  TG LK+   LD     +  +++ V D G+    A   L V ++
Sbjct: 765  FMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV 813



 Score =  104 bits (260), Expect = 1e-21
 Identities = 126/508 (24%), Positives = 207/508 (40%), Gaps = 43/508 (8%)

Query: 610  FTQPEYTVRLNEDAAVGTSV---VTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 666
            FT  EY V + E++A  T V   V +          + Y+I SG++ N F       G  
Sbjct: 34   FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93

Query: 667  VSLALP--------LDYKLERQYVLAVTASDGTRQDTAQ--IVVNVTDANTHRPVFQSSH 716
              L +         L+ +++  Y L V A +      A+  + V V D N  RP+F  + 
Sbjct: 94   CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153

Query: 717  YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE 776
            Y+V++ E+    T++  +SATD D G N    Y  +D    F I   +G +     LDY 
Sbjct: 154  YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYL 213

Query: 777  DQVSYTLAITARDNGIPQK-----SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPF 831
            +   Y + I A D G+        S    L + +   N+ AP     +   S  +  P +
Sbjct: 214  ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAY 273

Query: 832  TSVLQISATDRDSGLNGRV-FYTFQGGDDGDGDFIVESTSGI----VRTLRRLDRE-NVA 885
              V   +  D D G NG +   +   GD       V S  G     V+ +  +D + +  
Sbjct: 274  AIV---TVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF 330

Query: 886  QYVLRAYAVDKGMPPARTPMEVT-VTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVT 944
             Y L   A DKG PP  + ++V  VT       P  FE+D +   + E +P    V  V 
Sbjct: 331  GYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVK 390

Query: 945  ATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLV 1004
            A      ++ + +++   G     F L+  +G ++ L  +  +    + L  + T++   
Sbjct: 391  AI--PAYSHLRYVFKSTPGKAK--FSLNYNTGLISILEPVKRQQAAHFEL--EVTTSDRK 444

Query: 1005 SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDS--LT 1061
            +   V V++L  N NPP     E     Y      + P G  +  + A DPD  ++  +T
Sbjct: 445  ASTKVLVKVLGANSNPP-----EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVT 499

Query: 1062 YSFERGNELSLVLLNASTGELKLSRALD 1089
            YS    N +    ++  TG +  S  LD
Sbjct: 500  YSIANLNHVPFA-IDHFTGAVSTSENLD 526



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 105/437 (24%), Positives = 158/437 (36%), Gaps = 88/437 (20%)

Query: 1551 VDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQ-WDA-FSCECPLGFGGKS 1608
            V  RH   A  +   G    CP   + C+ + C  G  CV+  W+   +C CP G  G+ 
Sbjct: 3770 VTPRHHRAAVCLCKEGR---CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQC 3826

Query: 1609 CAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQL 1668
                 ++     G+S V +            L++  RT     V++ A  RG     L++
Sbjct: 3827 PG---SSSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMYA--RGTDYSILEI 3881

Query: 1669 REGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEG 1728
              G +    +  G     + ++  + NDG WH   +AL  +G     +L   +    A G
Sbjct: 3882 HHGRLQYKFD-CGSGPGIVSVQSIQVNDGQWH--AVALEVNGNYARLVLDQVH---TASG 3935

Query: 1729 NLGPRLHGLHLSNITV--------GGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPS 1780
                 L  L+L N           G   G +  V  GFRGC+  + ++     +NS   S
Sbjct: 3936 TAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRS 3995

Query: 1781 HG---ESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPC 1837
            +    ES++V  GC L                                   T  C  NPC
Sbjct: 3996 YAHIEESVDVSPGCFL---------------------------------TATEDCASNPC 4022

Query: 1838 EHQSVCTRKPSAPHGYTCECPPNYLGPYCETRID----QPCPRGWWGHPTCGPCNCDVSK 1893
            ++  VC   PS   GY C+C   Y+G +CE  ++    +PC  G       G C  D + 
Sbjct: 4023 QNGGVCN--PSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYG-------GTCVVD-NG 4072

Query: 1894 GFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQ-CPCKPGVIGR 1952
            GF   C        C+ + Y          C   P  +     D  DG  C C  G  G 
Sbjct: 4073 GFVCQCRGLYTGQRCQLSPY----------CKDEPCKNGGTCFDSLDGAVCQCDSGFRG- 4121

Query: 1953 QCDRCDNPFAEVTTNGC 1969
              +RC +   E + N C
Sbjct: 4122 --ERCQSDIDECSGNPC 4136



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 42/99 (42%), Positives = 52/99 (52%), Gaps = 5/99 (5%)

Query: 1268 PVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSA 1327
            P GG  C+C   + G +CE  V+ C S+PC   G C    GG+ C CR  YTG+ C++S 
Sbjct: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSP 4091

Query: 1328 RSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ 1366
                C    CKNGGTC + L G   C C SG F    CQ
Sbjct: 4092 ---YCKDEPCKNGGTCFDSLDGAV-CQCDSG-FRGERCQ 4125



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 22/96 (22%)

Query: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
            C  EPC+N   C     FDS                 + G  C+C  GF G+ C++++D 
Sbjct: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130

Query: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSA 1327
            C   PC     C +  G Y C C   Y G HCE +A
Sbjct: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAA 4166



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 8/83 (9%)

Query: 1789 QGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC---TNVCDLNPCEHQSVCTR 1845
            Q C L   C   PC     C +  D   C CD G+ G+ C    + C  NPC H ++C  
Sbjct: 4085 QRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCEN 4144

Query: 1846 KPSAPHG-YTCECPPNYLGPYCE 1867
                 HG Y C C   Y G +CE
Sbjct: 4145 ----THGSYHCNCSHEYRGRHCE 4163



 Score = 56.2 bits (134), Expect = 5e-07
 Identities = 34/83 (40%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 1287 TEVDLCYSRPCGPHGRCR-SREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVN 1345
            T  + C S PC   G C  S  GGY C C   Y G HCE+S     C+   C  GGTCV 
Sbjct: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP--CSSKPCLYGGTCV- 4068

Query: 1346 LLVGGFKCDCPSGDFEKPYCQVT 1368
            +  GGF C C  G +    CQ++
Sbjct: 4069 VDNGGFVCQC-RGLYTGQRCQLS 4090



 Score = 39.7 bits (91), Expect = 0.044
 Identities = 61/291 (20%), Positives = 102/291 (35%), Gaps = 68/291 (23%)

Query: 1571 CPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGL 1630
            C +  + C  N C +G  C N   ++ C C   + G+ C  E A P  +           
Sbjct: 4124 CQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHC--EDAAPNQY----------- 4170

Query: 1631 SLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLE 1690
               +S PW + L      A+G+ +     G   + +       M+S           R +
Sbjct: 4171 ---VSTPWNIGL------AEGIGIVVFVAGIFLLVVVFVLCRKMIS-----------RKK 4210

Query: 1691 PGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPG- 1749
              +A   D H          GP  A L   Y   +   N+   +    +    +   P  
Sbjct: 4211 KHQAEPKDKHL---------GPATAFLQRPYFDSKLNKNIYSDIPP-QVPVRPISYTPSI 4260

Query: 1750 PAGGVARGFRGCLQGVRVSDTPEGVNSLDP----SHGESINVEQGCSL-----PDPCDSN 1800
            P+       R   +G  + + PE  ++ +P     H +++ V   CS+     P P  ++
Sbjct: 4261 PSDSRNNLDRNSFEGSAIPEHPE-FSTFNPESVHGHRKAVAV---CSVAPNLPPPPPSNS 4316

Query: 1801 PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPH 1851
            P  ++S     WD            D  T V DL+PC  +     KPS P+
Sbjct: 4317 PSDSDSIQKPSWDF-----------DYDTKVVDLDPCLSKKPLEEKPSQPY 4356


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  481 bits (1239), Expect = e-135
 Identities = 414/1473 (28%), Positives = 646/1473 (43%), Gaps = 155/1473 (10%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F    Y  T+ E+   G+ V +LR +         +        ++     F ++  T
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERP---ENNKGGIFVIEQET 2762

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT----ILVTDTNDHDPVFEQQEY 294
            G +   + LDRET     F+V A    +P        T    I V D ND+ PVFE   Y
Sbjct: 2763 GTIKLDKRLDRETSPAFHFKVAAT---IPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSY 2819

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSP-SEVFEIDPRSGVIRTRG 353
               + E + VG ++  VRA D D   N  + Y L   S      E F ID  +G I T  
Sbjct: 2820 DTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLK 2879

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
             +D E   ++  +V ASD G +    S+TA V + V D NDNAP F+++ Y   V+E   
Sbjct: 2880 DLDHETDPTFTFSVVASDLG-EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938

Query: 414  PGAPVLRVTASDRDKGS-NAVVHYSIMSGNARGQFYLDAQTGALDVV--SPLDYETTKEY 470
            PG  V  ++  DRD    N  V Y I  GN RG+F L        V    PLD E    Y
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998

Query: 471  TLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530
             L + A DG    L     +V V V D+NDN+P+     + A + E +P   ++L V A 
Sbjct: 2999 FLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAK 3054

Query: 531  DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
            DAD G N  + Y L G G+   F ++  +G +   A LDRE +  YS   +A D G    
Sbjct: 3055 DADIGSNGYIRYSLYGSGNS-EFFLDPESGELKTLALLDRERIPVYSLMAKATDGG--GR 3111

Query: 591  TASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQIT 648
               +++ + + DVNDN P F+   Y   + E+ A    +  V AVD D   +  + Y + 
Sbjct: 3112 FCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLA 3171

Query: 649  SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQ----IVVNVTD 704
              +    FSI S SG  ++ L  PLD + +  Y ++V A+D +   +      + + V D
Sbjct: 3172 D-SAGGVFSIDSSSG--IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLD 3228

Query: 705  ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDA 762
             N + PVF+   Y V V ED   GT V+ + AT +D G NA ITY +     Q  F+I+ 
Sbjct: 3229 INDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINP 3288

Query: 763  DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
             TG ++    LDYE    + L + A+D G P  S    + I + DVNDN P+F +D Y  
Sbjct: 3289 KTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSA 3348

Query: 823  SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
             + ED     SV+ + A D DS  NG++ ++   GD  D +F V+   G+V+  ++LDRE
Sbjct: 3349 VISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR-DNEFTVDPVLGLVKVKKKLDRE 3407

Query: 883  NVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR 942
             V+ Y L   AVD G+P   +   V + + DVNDN PVF    +   ++EN P+G ++ +
Sbjct: 3408 RVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQ 3467

Query: 943  VTATDPDEGTNA-QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA 1001
            +  TD D   N     + I+ GN  E F LD   G L + V   + +  EYVL +QA  +
Sbjct: 3468 LVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDS 3526

Query: 1002 ---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISD 1058
                 VS   + VR+++ + + P     EI    ++      FPGG IG++ A D D+ D
Sbjct: 3527 GKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FIVTMEDDFPGGVIGKIHATDQDMYD 3582

Query: 1059 SLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVT 1118
             LT++  +  + SL  +N+  G++     LD+ +    +++V VSDG   V     + V 
Sbjct: 3583 VLTFAL-KSEQKSLFKVNSHDGKIIALGGLDSGK---YVLNVSVSDGRFQVPIDVVVHVE 3638

Query: 1119 IITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVA-ATLATPPDHVVVFNVQRDTDAPG 1177
             +  EML +++T+R E++SPE F+   +  F + +  A L    D + + ++Q      G
Sbjct: 3639 QLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISIQ---PVAG 3695

Query: 1178 GHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPC 1237
             + L++  +V         P +L  +    R +L        +  R+    +  C    C
Sbjct: 3696 TNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLE-------NIMRISAILEKNCSGLDC 3748

Query: 1238 ENYMRCVSVLRFDSSAPFIASSS-VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRP 1296
            +    C   L  DS A    S++ + F        +RC C     G  C    D C  +P
Sbjct: 3749 QE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTC----NGGLCPGSNDPCVEKP 3803

Query: 1297 CGPHGRCRSREGG---YTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKC 1353
            C    +C S E     + C C  G  GE C     SG                       
Sbjct: 3804 CPGDMQCVSYEASRRPFLCQCPPGKLGE-C-----SGH---------------------- 3835

Query: 1354 DCPSGDFEKPYCQVTTRSFPAHSFITFR--GLRQRFHFTLALSFATKERDGLLLYNGRFN 1411
                          T+ SF  +S+I +R     +   F LAL   T + +G+++Y     
Sbjct: 3836 --------------TSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMY----T 3877

Query: 1412 EKHDFVALEVIQEQV--QLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTG 1469
              +  + L+++  ++  QL   +G     +S      V+DG WH+V L+           
Sbjct: 3878 RANPCIILKIVDGKLWFQLDCGSGPGILGIS---GRAVNDGSWHSVFLELNRN--FTSLS 3932

Query: 1470 LPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSL-DLTGPLLLGGV 1528
            L     E++ A +      T  ++ FG+++          Q  + +SL D     +L G 
Sbjct: 3933 LDDSYVERRRAPLYFQTLSTESSIYFGALV----------QADNIRSLTDTRVTQVLSG- 3981

Query: 1529 PDLPESFPVRMRQFVGCM-------RNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSN 1581
                         F GC+         L + ++    A+ +       GC    + C  +
Sbjct: 3982 -------------FQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRS 4028

Query: 1582 TCHNGGTCVN-QWDAFSCECPLGFGGKSCAQEM 1613
             C +GG+C       + C C   F G++C  E+
Sbjct: 4029 PCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEI 4061



 Score =  422 bits (1086), Expect = e-117
 Identities = 319/1016 (31%), Positives = 497/1016 (48%), Gaps = 75/1016 (7%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            +P F P SY   V E+ P GT +A L   DPD G  G++ Y++   ++ R    F +D  
Sbjct: 933  SPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR----FEIDKA 988

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTND--HDPVFEQQEY 294
            +GA+  ++ELD E +  +   V A+D G P   S+++ + + V D N+  H P F     
Sbjct: 989  SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
              S++EN  +G  VL V A D D+  +  I Y + +GSG      F ID  SGVI     
Sbjct: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADI 1105

Query: 355  VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
            +DRE + SY LTV A+D+G    P  +T  V++ VED NDNAP  SE  Y   V E+   
Sbjct: 1106 LDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPK 1163

Query: 415  GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS-PLDYETTKEYTLR 473
               V+++ A D D  SN  + Y I SGN +  F ++ +TG +   S  LD E   E+ L 
Sbjct: 1164 DVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLE 1223

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE--SVPLGYLVLHVQAID 531
            V   DGG  P  +   +V VQVLD NDN P F    +Q  + E      G  +    A D
Sbjct: 1224 VTVTDGGPSPKQSTIWVV-VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282

Query: 532  ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
             D G NA + Y +     D  F I+  TG +S   +      D  +  ++A D+G P  +
Sbjct: 1283 RDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVDNGRPQKS 1340

Query: 592  ASASVSVTVLDVNDNNP---TFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 648
            ++A + +  +     +P   TF +P Y   + E   V T +V V +V + A++ + + I 
Sbjct: 1341 STARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVVSV-QPANTPLWFDIV 1398

Query: 649  SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTH 708
             GN  + F   ++ G G + +A PLD +    Y ++V  +DGT     Q+ + V D N +
Sbjct: 1399 GGNFDSAFD--AEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDN 1456

Query: 709  RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-----QFRIDAD 763
             P F   +Y V ++ED    T ++ I ATD D  E  +++Y +  SI      +FRID  
Sbjct: 1457 GPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPS 1514

Query: 764  TGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGS 823
            TG + T   LD+E Q  + L I  RD   P + +   + + V D ND++P F    Y+ S
Sbjct: 1515 TGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS 1574

Query: 824  VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDREN 883
            V+E     ++VLQ++A D+D G N  + YT + G+ G+  F +E   GI+   +  D   
Sbjct: 1575 VFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN-MFKIEPVLGIITICKEPDMTT 1633

Query: 884  VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
            + Q+VL     D+G PP      V ++V   +++ P F   ++   V EN  IG +V  +
Sbjct: 1634 MGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILI 1693

Query: 944  TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS-AP 1002
            +A      + + ++Y++ +G+I  +F ++ +SG +T    LDYE    Y L+IQAT+ A 
Sbjct: 1694 SAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG 1748

Query: 1003 LVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGR--------VPAHDP 1054
            + S ATV+++++D NDN PV      LF+ Y  + S + P  +I R        + A D 
Sbjct: 1749 MASNATVNIQIVDENDNAPV-----FLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803

Query: 1055 DISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTA 1111
            D + +  L Y            +++STG ++    LD+         V V D G   +TA
Sbjct: 1804 DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTA 1863

Query: 1112 QCALRVTI-ITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVV 1166
            +  + V I +TD          + D  P         +F QAV  T+   P +V V
Sbjct: 1864 ESPVEVNIEVTD----------VNDNPP---------VFTQAVFETILLLPTYVGV 1900



 Score =  395 bits (1016), Expect = e-109
 Identities = 305/1030 (29%), Positives = 493/1030 (47%), Gaps = 98/1030 (9%)

Query: 174  NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
            N +  P+F  P+Y  T+ E+    T +  + A D DE    +L YT+ +  DS S + F 
Sbjct: 1453 NNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISMRKFR 1510

Query: 234  LDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293
            +DP TG + TAE LD E +  H+  +  +D   P R  LA + + V D NDH P F    
Sbjct: 1511 IDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL 1570

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            Y+ S+ E+  +G  VL V A D D   NA ++Y +  G+ G+   +F+I+P  G+I    
Sbjct: 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN---MFKIEPVLGIITICK 1627

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
              D   +  + L+++ +DQG    P S TA V +SV   +++ P+F  K Y  +V E+V 
Sbjct: 1628 EPDMTTMGQFVLSIKVTDQGSP--PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD 1685

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
             G  V+ ++A      S + + Y +  G+  G F ++  +G +     LDYE T  Y L 
Sbjct: 1686 IGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740

Query: 474  VRAQDGGRPPLSNVSGL-----VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV---- 524
            ++A        +N++G+     V +Q++D NDNAP+F+ + +  ++ E+ P+  +V    
Sbjct: 1741 IQA--------TNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLD 1792

Query: 525  ---LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVE 581
               L ++A DAD+  NA L Y++        FT+++ TG I   A LD E +  + F V 
Sbjct: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852

Query: 582  ARDHGTPALTASA--SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
             RD G+P LTA +   V++ V DVNDN P FTQ  +   L     VG  V+ VSA D D+
Sbjct: 1853 VRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDS 1912

Query: 640  H--SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQ 697
                 +TY +  G+  + F I S SG     L +  +   +  Y+L V  SDG    T+ 
Sbjct: 1913 EVPPELTYSLMEGSL-DHFLIDSNSG----VLTIKNNNLSKDHYMLIVKVSDGKFYSTSM 1967

Query: 698  IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
            + + V +A      F  S Y+ +++E+    T V +++A       N  + Y + +   +
Sbjct: 1968 VTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNPGNK 2025

Query: 758  FRIDADTGAV-TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL 816
            F+I + +G + TT    D E+Q  Y L + A       +     + + + D+NDN+P F+
Sbjct: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085

Query: 817  RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG--IVR 874
               Y  +V  D  P T + Q++A D+D G NG V Y  Q   D  G F +   SG  I++
Sbjct: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNSGNVILK 2142

Query: 875  TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
                 D  N+ +Y +   A D G P   T +E+ +T+  VN   PVF++  +   V E+ 
Sbjct: 2143 EAFNSDLSNI-EYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNEDI 2199

Query: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
             +   +  + AT P+      I+Y I++G+  + F +D  +G L  +  LDYE    Y L
Sbjct: 2200 RMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKL 2256

Query: 995  VIQATSAPLVSRATVHVRLL--DRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
             I+A+ A   +RA V V LL  D NDNPP+    +  +N   T   +S  G  + +V + 
Sbjct: 2257 TIRASDALTGARAEVTVDLLVNDVNDNPPIFD--QPTYN--TTLSEASLIGTPVLQVVSI 2312

Query: 1053 DPDISDSLTYSF----ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHS 1108
            D D  ++    +    +  N      +++S+G +  +R LD                 H 
Sbjct: 2313 DADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLD-----------------HE 2355

Query: 1109 VTAQCALRVTII-------TDEMLTHSITLRLEDMSP-------ERFLSPLL--GLFIQA 1152
            +   C L+V  I       + E+L H     + D  P       E ++S L   G F+  
Sbjct: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTC 2415

Query: 1153 VAATLATPPD 1162
            V A+ A   D
Sbjct: 2416 VQASDADSSD 2425



 Score =  375 bits (964), Expect = e-103
 Identities = 319/1089 (29%), Positives = 498/1089 (45%), Gaps = 106/1089 (9%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+FQ P Y A V E+ P GT V ++ A D D+GE G + Y++ +L    +   F ++  T
Sbjct: 470  PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASL----NLLPFVINQFT 525

Query: 239  GAVTTAEELDRETK-STHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKE 296
            G ++T EELD E+    + F V A D G P R  +   +TI + + ND+ P+FE+   + 
Sbjct: 526  GVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQG 585

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             +  +  VG  +  V A D D      + Y+++ G+       F ++P SGV++ +  + 
Sbjct: 586  VISYDFPVGGHITAVSAIDIDELEL--VKYKIISGN---ELGFFYLNPDSGVLQLKKSLT 640

Query: 357  REEVES--YQLTVEASDQGRDPGPRSTTAAVF---------------------------- 386
               +++  + L + A+D      P S   +V                             
Sbjct: 641  NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700

Query: 387  -----LSVEDD-------NDNAPQFSEK-RYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
                 L++ED        N   P F +     V V+ED+  GA +L++ A D D G N  
Sbjct: 701  KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760

Query: 434  VHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTV 493
            V ++I  GN    F +D +TG L V+ P+D E T  Y L +   D G P  S+   L+T+
Sbjct: 761  VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWR-LLTI 819

Query: 494  QVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
             V D NDN+P+F+   +   +LES  +G  ++ V+A D D G N  + Y +  +     F
Sbjct: 820  NVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDTQQF 877

Query: 554  TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVL--DVNDNNPTFT 611
             IN+ TG + VA +LDRE    YS  +EARD         + V++ V   DVND +P F 
Sbjct: 878  AINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937

Query: 612  QPEYTVRLNEDAAVGTSVVTVSAVDRDAH--SVITYQITSGNTRNRFSITSQSGGGLVSL 669
               Y+V++ ED  VGT +  +   D D      + Y + + +   RF I   SG   + L
Sbjct: 938  PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGA--IRL 994

Query: 670  ALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT--HRPVFQSSHYTVNVNE 723
            +  LDY+ ++ Y L V A D  R       + + V V D N   H P F       +V E
Sbjct: 995  SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE 1054

Query: 724  DRPAGTTVVLISATDEDTGENARITYFMEDS--IPQFRIDADTGAVTTQAELDYEDQVSY 781
            +   GT+V+ ++A DED+G +  I Y + D   + +F ID ++G +T    LD E   SY
Sbjct: 1055 NSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSY 1114

Query: 782  TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
             L + A D G+     T  + I V DVNDNAP      Y   V E+ P   SV+QI A D
Sbjct: 1115 WLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAED 1174

Query: 842  RDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA 901
             DS  N ++ Y    G+  +   I   T  I  T R+LDRE  A++ L     D G  P 
Sbjct: 1175 PDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPK 1234

Query: 902  RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEE--NSPIGLAVARVTATDPDEGTNAQIMYQ 959
            ++ + V V VLD NDN P F +  + + + E      G  + R  A D DEG NA+I Y 
Sbjct: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294

Query: 960  IVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS---APLVSRATVHVRLLDR 1016
            IV+GN    F +D  +G +++     +      +L I+A         S A +H+  + +
Sbjct: 1295 IVDGNDDGKFFIDPKTGMVSS--RKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKK 1352

Query: 1017 NDNPPVLGNFEILFNNYVTNRSSSFPG--GAIGRVPAHDPDISDSLTYSFERGNELSLVL 1074
                P+   F+  F N+    S       G +   PA+ P     L +    GN  S   
Sbjct: 1353 PPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNFDSAFD 1407

Query: 1075 LNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRV----------------T 1118
                 G + +++ LD  +     MSV V+DG +    Q  ++V                 
Sbjct: 1408 AEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDV 1467

Query: 1119 IITDEMLTHSITLRLE--DMSPERFLSPLLGLFIQAVA-ATLATPPDHVVVFNVQR-DTD 1174
             I++++L  +  L++E  D   +  LS  +   I +++       P   V++  +R D +
Sbjct: 1468 TISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHE 1527

Query: 1175 APGGHILNV 1183
            A   HILN+
Sbjct: 1528 AQDKHILNI 1536



 Score =  351 bits (901), Expect = 5e-96
 Identities = 286/954 (29%), Positives = 468/954 (49%), Gaps = 51/954 (5%)

Query: 190  VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
            V E+ P G  +  ++A D D G  G++ +T+    D  ++  F++D  TG +     +DR
Sbjct: 735  VKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPMDR 791

Query: 250  ETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVL 309
            E    ++  +T  D G P++S+   LTI V D ND+ PVF Q  Y  ++ E+  +G E++
Sbjct: 792  EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII 851

Query: 310  TVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEA 369
             V A D D   N  + Y +L     + ++ F I+  +G++     +DRE   +Y L +EA
Sbjct: 852  QVEARDKDLGSNGEVTYSVL-----TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEA 906

Query: 370  SDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKG 429
             D+        +   + + ++D ND +P F    Y V+V ED+  G  +  +   D D G
Sbjct: 907  RDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG 966

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP-PLSNVS 488
                V YS+++ +  G+F +D  +GA+ +   LDYE  + Y L VRA+D GRP  LS+VS
Sbjct: 967  LGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVS 1025

Query: 489  GLVTVQVLDINDN--APIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-- 544
              V V+V+D+N+N   P F       +V E+  +G  VL V A D D+G +  ++Y +  
Sbjct: 1026 -FVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084

Query: 545  -AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDV 603
             +G+G    F+I++ +G I+ A  LDRE +  Y   V A D G   L ++  V + V DV
Sbjct: 1085 GSGLGR---FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDV 1141

Query: 604  NDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITSGNTRNRFSITSQ 661
            NDN P  ++P Y   + E++    SV+ + A D D+ S   +TY+ITSGN +N F+I  +
Sbjct: 1142 NDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIK 1201

Query: 662  SGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYT 718
            + G + + +  LD + + ++ L VT +DG    +Q T  +VV V D N ++P F    Y 
Sbjct: 1202 T-GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ 1260

Query: 719  VNVNE--DRPAGTTVVLISATDEDTGENARITYFMEDSIP--QFRIDADTGAVTTQAELD 774
            + + E   +  G  +    A D D G NA I+Y + D     +F ID  TG V+++ +  
Sbjct: 1261 IKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF- 1319

Query: 775  YEDQVSY-TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE-DVPPFT 832
                 SY  L I A DNG PQKS T  L I    +    P  +  ++    Y   V    
Sbjct: 1320 --TAGSYDILTIKAVDNGRPQKSSTARLHI--EWIKKPPPSPIPLTFDEPFYNFTVMESD 1375

Query: 833  SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAY 892
             V +I         N  +++   GG + D  F  E   G +   + LD E  + Y +   
Sbjct: 1376 RVTEIVGVVSVQPANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVE 1434

Query: 893  AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
              D G   A T  +V + VLD NDN P F Q  +DV + E+      + ++ ATD DE  
Sbjct: 1435 VTD-GTNVAVT--QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH 1491

Query: 953  N-AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR---AT 1008
              +  ++  ++      F++D  +G L     LD+E + +++L I         R   A 
Sbjct: 1492 KLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551

Query: 1009 VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFER 1066
            V V + D ND+ P   N   L+   V    S+  G A+ +V A D D  ++  L Y+ E 
Sbjct: 1552 VIVNVEDANDHSPYFTN--PLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEA 1607

Query: 1067 GNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTI 1119
            GN  ++  +    G + + +  D     + ++S+ V+D G   ++A   +R+++
Sbjct: 1608 GNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661



 Score =  346 bits (887), Expect = 2e-94
 Identities = 276/939 (29%), Positives = 436/939 (46%), Gaps = 53/939 (5%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + +P F   SY   + E+   GT +  + A D D G  G + Y++  L D+   Q F+++
Sbjct: 826  DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDT---QQFAIN 880

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRS--ALATLTILVTDTNDHDPVFEQQE 293
              TG V  A++LDRE+K+ +  ++ A+D     +   ++ TL + + D ND  P F    
Sbjct: 881  SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            Y   + E+L VG  +  +   D D      + Y L+    G     FEID  SG IR   
Sbjct: 941  YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR----FEIDKASGAIRLSK 996

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN--APQFSEKRYVVQVRED 411
             +D E+ + Y LTV A D+GR P   S+ + V + V D N+N   P F +   V  V+E+
Sbjct: 997  ELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055

Query: 412  VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT 471
               G  VL+VTA D D G +  + YSI  G+  G+F +D ++G +     LD ET   Y 
Sbjct: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYW 1115

Query: 472  LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAID 531
            L V A D G  PL +    V ++V D+NDNAP+     +   V+E+ P    V+ +QA D
Sbjct: 1116 LTVYATDRGVVPLYSTIE-VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAED 1174

Query: 532  ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPAL 590
             D+  N +L YR+        F IN  TG I+  + +LDRE+   +   V   D G    
Sbjct: 1175 PDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPK 1234

Query: 591  TASASVSVTVLDVNDNNPTFTQPEYTVRLNE--DAAVGTSVVTVSAVDRD--AHSVITYQ 646
             ++  V V VLD NDN P F +  Y ++L E      G  +    A DRD   ++ I+Y 
Sbjct: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294

Query: 647  ITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVT 703
            I  GN   +F I  ++G     ++    +      +L + A D  R     TA++ +   
Sbjct: 1295 IVDGNDDGKFFIDPKTG----MVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWI 1350

Query: 704  DANTHRPV---FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRI 760
                  P+   F    Y   V E       V ++S    +T     I     DS   F  
Sbjct: 1351 KKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDS--AFDA 1408

Query: 761  DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
            +   G +     LD E +  Y +++   D         T + I V D NDN P+F + +Y
Sbjct: 1409 EKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPEFSQPNY 1465

Query: 821  QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDG--DFIVESTSGIVRTLRR 878
              ++ EDV P T +LQI ATDRD     ++ YT     D      F ++ ++G++ T  R
Sbjct: 1466 DVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAER 1523

Query: 879  LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
            LD E   +++L     D+  P  R    V V V D ND+ P F    ++  V E++ +G 
Sbjct: 1524 LDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGS 1583

Query: 939  AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
            AV +VTA D D+G NA+++Y I  GN   +F+++   G +T   + D     ++VL I+ 
Sbjct: 1584 AVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKV 1643

Query: 999  T---SAPLVSRATVHVRLLDRNDNPP--VLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
            T   S P+ + A V + +   +++ P  +  +++   N  V   +S     AI +     
Sbjct: 1644 TDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ----- 1698

Query: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNR 1092
                 +L Y  + G+   +  +N  +G +   +ALD  R
Sbjct: 1699 ----STLIYEVKDGDINGIFTINPYSGVITTQKALDYER 1733



 Score =  338 bits (868), Expect = 4e-92
 Identities = 266/872 (30%), Positives = 419/872 (48%), Gaps = 64/872 (7%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + AP    P Y   V EN P    V  ++A DPD     +L Y + +        FF+++
Sbjct: 1143 DNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS---GNPQNFFAIN 1199

Query: 236  PVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
              TG + TT+ +LDRE ++ H   VT  D G   + +   + + V D ND+ P F ++ Y
Sbjct: 1200 IKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVY 1259

Query: 295  KESL--RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTR 352
            +  L  R+  + G  +    A D D  PNA I Y +++G+       F IDP++G++ +R
Sbjct: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGK---FFIDPKTGMVSSR 1316

Query: 353  GPVDREEVESYQ-LTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP---QFSEKRYVVQV 408
                +    SY  LT++A D GR    +S+TA + +        +P    F E  Y   V
Sbjct: 1317 ---KQFTAGSYDILTIKAVDNGRP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371

Query: 409  RED--VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET 466
             E   VT    V+ V      + +N  + + I+ GN    F  +   G + +  PLD E 
Sbjct: 1372 MESDRVTEIVGVVSV------QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQ 1425

Query: 467  TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
               Y + V   DG    ++     V ++VLD NDN P F    +  T+ E V     +L 
Sbjct: 1426 RSIYNMSVEVTDGTNVAVTQ----VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481

Query: 527  VQAIDADAGDNARLEYRLAGVGHDF---PFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
            ++A D D  +  +L Y +           F I+  TG +  A  LD E  D +   +  R
Sbjct: 1482 IEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539

Query: 584  DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHS 641
            D   P     A V V V D ND++P FT P Y   + E AA+G++V+ V+A+D+D   ++
Sbjct: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENA 1599

Query: 642  VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD---GTRQDTAQI 698
             + Y I +GNT N F I  +   G++++    D     Q+VL++  +D        TA +
Sbjct: 1600 ELIYTIEAGNTGNMFKI--EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ- 757
             ++VT ++   P F    Y   VNE+   GT+V+LISA  + T     + Y ++D     
Sbjct: 1658 RISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDING 1712

Query: 758  -FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL 816
             F I+  +G +TTQ  LDYE   SY L I A +      + T  ++I+  D NDNAP FL
Sbjct: 1713 IFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFL 1770

Query: 817  RDSYQGSVYEDVPPFT-------SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
               Y GS+ E  P  +       S L I ATD DS  N  + Y           F V+S+
Sbjct: 1771 FSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-ESTAKKFFTVDSS 1829

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMP--PARTPMEVTVTVLDVNDNPPVFEQDEFD 927
            +G +RT+  LD E +A +    +  D G P   A +P+EV + V DVNDNPPVF Q  F+
Sbjct: 1830 TGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFE 1889

Query: 928  VFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYE 987
              +   + +G+ V +V+ATDPD     ++ Y ++EG++ + F +D  SG LT  +  +  
Sbjct: 1890 TILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLT--IKNNNL 1946

Query: 988  DRPEYVLVIQATSAPLVSRATVHVRLLDRNDN 1019
             +  Y+L+++ +     S + V + + +  D+
Sbjct: 1947 SKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978



 Score =  334 bits (856), Expect = 9e-91
 Identities = 281/1023 (27%), Positives = 465/1023 (45%), Gaps = 97/1023 (9%)

Query: 174  NVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFF 232
            NVN  +P F+  + Q  +  + P G  + ++ AID DE     LE     +       FF
Sbjct: 570  NVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE-----LELVKYKIISGNELGFF 624

Query: 233  SLDPVTGAVTTAEELDRE--TKSTHVFRVTAQD---------------HGMPRRSALATL 275
             L+P +G +   + L            R+TA D               HG     + +  
Sbjct: 625  YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCR 684

Query: 276  TILVT---------------------------DTNDHDPVFEQQEYKE-SLRENLEVGYE 307
               V                              N   P F++    + +++E+L VG  
Sbjct: 685  ETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGAN 744

Query: 308  VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTV 367
            +L ++A D D+  N  +L+ +   S G+    F ID  +G ++   P+DRE  + Y L +
Sbjct: 745  ILKIKAYDADSGFNGKVLFTI---SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNI 801

Query: 368  EASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRD 427
               D G     +S+   + ++VED NDN+P F +  Y V + E    G  +++V A D+D
Sbjct: 802  TIYDLGNP--QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859

Query: 428  KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNV 487
             GSN  V YS+++     QF +++ TG + V   LD E+   Y+L++ A+D        +
Sbjct: 860  LGSNGEVTYSVLTDTQ--QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG-QQL 916

Query: 488  SGLVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLA 545
              +VT++V   D+ND +P F+ + +   VLE +P+G ++  ++  D D G   ++ Y L 
Sbjct: 917  FSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976

Query: 546  GVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS-VSVTVLDVN 604
               ++  F I+  +G I ++ ELD E+  FY+  V A+D G P   +S S V V V+DVN
Sbjct: 977  N-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035

Query: 605  DNNPTFTQPEYTV--RLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITS 660
            +N  T   P++ V   + E++ +GTSV+ V+A D D+     I Y I  G+   RFSI  
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHY 717
            +S  G+++ A  LD +    Y L V A+D        T ++ + V D N + P+     Y
Sbjct: 1096 ES--GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQA-ELD 774
               V E+ P   +V+ I A D D+  N ++TY +    PQ  F I+  TG +TT + +LD
Sbjct: 1154 YPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLD 1213

Query: 775  YEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE--DVPPFT 832
             E Q  + L +T  D G   K  T ++ + V D NDN PQF    YQ  + E        
Sbjct: 1214 REQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGE 1273

Query: 833  SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAY 892
             + +  A DRD G N  + Y+   G+D DG F ++  +G+V + ++    +    +L   
Sbjct: 1274 PIYRAFAFDRDEGPNAEISYSIVDGND-DGKFFIDPKTGMVSSRKQFTAGSYD--ILTIK 1330

Query: 893  AVDKGMPPARTPMEVTVTVLDVNDNPPV---FEQDEFDVFVEENSPIGLAVARVTATDPD 949
            AVD G P   +   + +  +      P+   F++  ++  V E+  +   V  V+     
Sbjct: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSV---- 1386

Query: 950  EGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATV 1009
            +  N  + + IV GN    F  +   G +     LD E R  Y + ++ T    V+   V
Sbjct: 1387 QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQV 1446

Query: 1010 HVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGN 1068
             +++LD NDN P     E    NY VT      P   I ++ A D D    L+Y+     
Sbjct: 1447 FIKVLDNNDNGP-----EFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSI 1501

Query: 1069 E---LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEML 1125
            +   +    ++ STG L  +  LD+    + I++++V D         A RV +  ++  
Sbjct: 1502 DSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLA-RVIVNVEDAN 1560

Query: 1126 THS 1128
             HS
Sbjct: 1561 DHS 1563



 Score =  332 bits (850), Expect = 4e-90
 Identities = 274/973 (28%), Positives = 464/973 (47%), Gaps = 68/973 (6%)

Query: 179  PQFQPPSYQATVPEN--QPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
            PQF    YQ  +PE   +  G P+    A D DEG    + Y+   + D   +  F +DP
Sbjct: 1252 PQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS---IVDGNDDGKFFIDP 1308

Query: 237  VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV---FEQQE 293
             TG V++ ++      S  +  + A D+G P++S+ A L I         P+   F++  
Sbjct: 1309 KTGMVSSRKQFT--AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            Y  ++ E+  V   V  V     + P   +I+       GG+    F+ +   G I    
Sbjct: 1367 YNFTVMESDRVTEIVGVVSVQPANTPLWFDIV-------GGNFDSAFDAEKGVGTIVIAK 1419

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
            P+D E+   Y ++VE +D     G       VF+ V D+NDN P+FS+  Y V + EDV 
Sbjct: 1420 PLDAEQRSIYNMSVEVTD-----GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474

Query: 414  PGAPVLRVTASDRDKGSNA--VVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT 471
            P   +L++ A+DRD+       VH SI S + R +F +D  TG L     LD+E   ++ 
Sbjct: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMR-KFRIDPSTGVLYTAERLDHEAQDKHI 1533

Query: 472  LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAID 531
            L +  +D   P   N++ ++ V V D ND++P F +  ++A+V ES  LG  VL V A+D
Sbjct: 1534 LNIMVRDQEFPYRRNLARVI-VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALD 1592

Query: 532  ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
             D G+NA L Y +        F I    G I++  E D   +  +   ++  D G+P ++
Sbjct: 1593 KDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMS 1652

Query: 592  ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN 651
            A+A V ++V   ++++P F   +Y   +NE+  +GTSV+ +SA+   + S + Y++  G+
Sbjct: 1653 ATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKDGD 1709

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRP 710
                F+I   S  G+++    LDY+    Y L + A++       A + + + D N + P
Sbjct: 1710 INGIFTINPYS--GVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAP 1767

Query: 711  VFQSSHYTVNVNEDRPAGTTV-------VLISATDEDTGENARITYFMEDSIPQ--FRID 761
            VF  S Y+ +++E  P  + V       ++I ATD D+  NA + Y + +S  +  F +D
Sbjct: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVD 1827

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE--ILVNDVNDNAPQFLRDS 819
            + TGA+ T A LD+E    +   +  RD+G PQ +  + +E  I V DVNDN P F +  
Sbjct: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887

Query: 820  YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
            ++  +         VL++SATD DS +   + Y+   G      F+++S SG++     +
Sbjct: 1888 FETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG--SLDHFLIDSNSGVL----TI 1941

Query: 880  DRENVAQ--YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
               N+++  Y+L     D       +   VT+ V +  D+   F Q  +   + EN+   
Sbjct: 1942 KNNNLSKDHYMLIVKVSDGKF---YSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998

Query: 938  LAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDLDYEDRPEYVLVI 996
              VA V A       N  + Y I+  N    F++   SG + T  V  D E++  Y LV+
Sbjct: 1999 TKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054

Query: 997  QAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
            +A+       V+R  V V + D NDN PV     +    Y   +  + PG  I +V A D
Sbjct: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVF----VGLPYYAAVQVDAEPGTLIYQVTAID 2110

Query: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNN-RPLEAIMSVLVSD-GVHSVTA 1111
             D   +   ++   ++     +N ++G + L  A +++   +E  +++L  D G  S++ 
Sbjct: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLST 2170

Query: 1112 QCALRVTIITDEM 1124
               L +TI+   M
Sbjct: 2171 SVELPITIVNKAM 2183



 Score =  330 bits (846), Expect = 1e-89
 Identities = 290/983 (29%), Positives = 453/983 (46%), Gaps = 68/983 (6%)

Query: 172  KRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF 231
            K  +++   F    Y  ++ EN    T VA + A+        RL   +     +  N+F
Sbjct: 1973 KEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV------GNRLNEPLKYSILNPGNKF 2026

Query: 232  FSLDPVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
              +   +G + TT    DRE +  +   V A       R A   + + + D ND+ PVF 
Sbjct: 2027 -KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085

Query: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG--V 348
               Y  +++ + E G  +  V A D D  PN  + Y L +  G      FEI+P SG  +
Sbjct: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH-----FEINPNSGNVI 2140

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
            ++     D   +E Y +T+ A D G+     S + +V L +   N   P F +  Y   V
Sbjct: 2141 LKEAFNSDLSNIE-YGVTILAKDGGKP----SLSTSVELPITIVNKAMPVFDKPFYTASV 2195

Query: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
             ED+    P+L + A+  + G   +  Y I+ G+   QF +D  TG L VVSPLDYE T 
Sbjct: 2196 NEDIRMNTPILSINATSPE-GQGII--YIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTS 2252

Query: 469  EYTLRVRAQDGGRPPLSNVSGLVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLH 526
             Y L +RA D     L+     VTV +L  D+NDN PIF    +  T+ E+  +G  VL 
Sbjct: 2253 AYKLTIRASDA----LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQ 2308

Query: 527  VQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEARD 584
            V +IDAD+ +N  + Y++    ++    F I++ +G I  A  LD E V   +  V + D
Sbjct: 2309 VVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSID 2368

Query: 585  HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV-- 642
             G P+L++   V + + DVNDN P F Q  Y   ++E A  G  V  V A D D+     
Sbjct: 2369 SGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR 2428

Query: 643  ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNV 702
            + Y I SGN R  F + S+S  G+++L+     ++E  Y L V+ SDG    TAQ+ + V
Sbjct: 2429 LEYSILSGNDRTSFLMDSKS--GVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRV 2486

Query: 703  TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
              AN + P F  S Y   V E+  AGT V+ + ATD D G   +I+Y + +   + R   
Sbjct: 2487 LGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLI 2546

Query: 763  DT-GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
            D+ G V T   LD E+ +   ++I  R      ++    + ++V D NDNAPQF+   Y+
Sbjct: 2547 DSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYR 2606

Query: 822  GSVYEDVPPFTSVLQISATDRDSGLNGRVFYT-FQGGDDGDGDFI-VESTSGIVRTLRRL 879
             SV  DV     V Q+ A D D G N R+ Y+ +        D + ++  +G + T    
Sbjct: 2607 ASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNF 2666

Query: 880  DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            ++           AVD G+P   + + V + VL      P F Q ++   + E++ IG  
Sbjct: 2667 NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726

Query: 940  VARVTATDPDEGTNAQIMYQIVEGNIPE-----VFQLDIFSGELTALVDLDYEDRPEYVL 994
            V  +         +  + +  V G  PE     +F ++  +G +     LD E  P +  
Sbjct: 2727 VDTLRIL-----PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781

Query: 995  VIQAT----SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRV 1049
             + AT       +V    V +++LD NDN PV   FE   ++Y T      P G  + +V
Sbjct: 2782 KVAATIPLDKVDIVFTVDVDIKVLDLNDNKPV---FET--SSYDTIIMEGMPVGTKLTQV 2836

Query: 1050 PAHDPD--ISDSLTYSFERGNELSLVL----LNASTGELKLSRALDNNRPLEAIMSVLVS 1103
             A D D   +  +TYS    ++   V+    ++++TG +   + LD+        SV+ S
Sbjct: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896

Query: 1104 DGVH----SVTAQCALRVTIITD 1122
            D       S TA  ++RVT I D
Sbjct: 2897 DLGEAFSLSSTALVSVRVTDIND 2919



 Score =  317 bits (812), Expect = 1e-85
 Identities = 283/998 (28%), Positives = 434/998 (43%), Gaps = 103/998 (10%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P +Y  T+ E+ P  T VA + A D D G  G   Y      D      FS+ P +
Sbjct: 156  PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTS 210

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRR-----SALATLTILVTDTNDHDPVFEQQE 293
            G ++ +  L+ + K+ +   + A D GM        S+ A L + +   N+H P      
Sbjct: 211  GVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT 270

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            +     E  E  Y V+TV     D    AN     +    G P + F +      +    
Sbjct: 271  HVPFSLEK-EPTYAVVTV----DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYK 325

Query: 354  PVDREEVE------SYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP-QFSEKRYVV 406
              +R++++       Y LT++A D+G  P   S   AV++      D  P +F ++ Y V
Sbjct: 326  IKERKQIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIG-NPTRDTVPIRFEKEVYDV 383

Query: 407  QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET 466
             + E   PG  V  V  S         V Y +  G     F ++ ++G +    PL+   
Sbjct: 384  SISEFSPPGVVVAIVKLSPEP----IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVK 439

Query: 467  TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
             + Y L V  ++G      ++   VT+ + D ND+ P F    + A V ESVP+G  VL 
Sbjct: 440  KEVYKLEVTNKEG------DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLT 493

Query: 527  VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDRE-EVDFYSFGVEARDH 585
            V A D D G+N  + Y +A + +  PF IN  TG IS   ELD E   + Y F V A D 
Sbjct: 494  VSASDKDKGENGYITYSIASL-NLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDW 552

Query: 586  GTPALTAS-ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVIT 644
            G+P    S  +V++ + +VNDN+P F +      ++ D  VG  +  VSA+D D   ++ 
Sbjct: 553  GSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVK 612

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVT 703
            Y+I SGN    F +   SG   +  +L         + L +TA+DG    D   I ++V 
Sbjct: 613  YKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVL 672

Query: 704  --------------------------------------------DANTHRPVFQSSHYT- 718
                                                          N   P F  S  + 
Sbjct: 673  HGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSD 732

Query: 719  VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYE 776
            V V ED P G  ++ I A D D+G N ++ + + D      F ID +TG +     +D E
Sbjct: 733  VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDRE 792

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
                Y L IT  D G PQKS    L I V D NDN+P F++DSY  ++ E     T ++Q
Sbjct: 793  HTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQ 852

Query: 837  ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
            + A D+D G NG V Y+          F + S++GIV    +LDRE+ A Y L+  A DK
Sbjct: 853  VEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909

Query: 897  GMPPARTPMEVTVTVL--DVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNA 954
                 +    VT+ V   DVND  P F    + V V E+ P+G  +A +   DPD G   
Sbjct: 910  AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGG 969

Query: 955  QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS----APLVSRATVH 1010
            Q+ Y +V  +    F++D  SG +    +LDYE +  Y L ++A        L S + V 
Sbjct: 970  QVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028

Query: 1011 VRLLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDI--SDSLTYSFER 1066
            V ++D N+N   P   +F ++     + + +S  G ++ +V A D D      + YS   
Sbjct: 1029 VEVVDVNENLHTPYFPDFAVV----GSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084

Query: 1067 GNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            G+ L    ++  +G +  +  LD        ++V  +D
Sbjct: 1085 GSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATD 1122



 Score =  302 bits (774), Expect = 3e-81
 Identities = 240/746 (32%), Positives = 352/746 (47%), Gaps = 37/746 (4%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + AP F    Y+  V E+ P G  VA L   D D  +  R         + R      L 
Sbjct: 2919 DNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLV 2978

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
                 V     LDRE +  +   +TA D     +   A + + V+D ND+ PV +Q  Y 
Sbjct: 2979 QSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---AMVEVSVSDVNDNSPVCDQVAYT 3035

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
              L E++     +L V A D D   N  I Y L  GSG S    F +DP SG ++T   +
Sbjct: 3036 ALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNSE---FFLDPESGELKTLALL 3091

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            DRE +  Y L  +A+D G     R   + + L +ED NDN P FS   Y   V E+    
Sbjct: 3092 DRERIPVYSLMAKATDGGG----RFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
            A + RV A D D G N  V YS+ + +A G F +D+ +G + +  PLD E    Y + VR
Sbjct: 3148 ALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVR 3206

Query: 476  AQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
            A D  + P  ++S L  VT+ VLDINDN P+F    +  TV E    G  VL V A   D
Sbjct: 3207 ATD--QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD 3264

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
             G NA + Y +        F IN  TG ISV+  LD E    +   VEA+D GTPAL+A 
Sbjct: 3265 IGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAV 3324

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA--VDRDAHSVITYQITSGN 651
            A+V++ + DVNDN P F+Q  Y+  ++EDA VG SV+ + A  VD   +  I + I +G+
Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
              N F++      GLV +   LD +    Y L V A D        TA + ++++D N +
Sbjct: 3385 RDNEFTVDPVL--GLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDN 3442

Query: 709  RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA---RITYFMEDSIPQFRIDADTG 765
             PVF  ++YT  + E++P GT+++ +  TD D+  N      +    +   +F +D   G
Sbjct: 3443 SPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-G 3501

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
             + +     + + + Y L + A+D+G PQ+   TY+ + V + + + P  +         
Sbjct: 3502 ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTM 3561

Query: 826  EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVA 885
            ED  P   + +I ATD+D         TF    +    F V S  G +  L  LD     
Sbjct: 3562 EDDFPGGVIGKIHATDQDM----YDVLTFALKSEQKSLFKVNSHDGKIIALGGLDS---G 3614

Query: 886  QYVLRAYAVDKGMPPARTPMEVTVTV 911
            +YVL     D      + P++V V V
Sbjct: 3615 KYVLNVSVSDGRF---QVPIDVVVHV 3637



 Score =  238 bits (608), Expect = 5e-62
 Identities = 236/914 (25%), Positives = 397/914 (43%), Gaps = 102/914 (11%)

Query: 247  LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
            L+RE +  ++  V     G     A   + I V D ND  P+F    Y  ++ E+  +  
Sbjct: 117  LNREIQDNYLLIVKGSVRGEDLE-AWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175

Query: 307  EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
             V  V ATD D   N    Y        +  ++F + P SGVI   G ++ +E   Y L 
Sbjct: 176  SVAQVTATDADIGSNGEFYYYFK-----NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLE 230

Query: 367  VEASDQGRD---PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
            + A D+G         S+TA +++ +E  N++AP       V  V   +        VT 
Sbjct: 231  ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTV 287

Query: 424  SDRDKGSNAVVH-YSIMSGNARGQFYLDAQTGALDVVS-----PLDYETTKE-YTLRVRA 476
             D D G+N  +   SI++G+   QF+L  +   L+         +D+E+    Y L ++A
Sbjct: 288  DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQA 347

Query: 477  QDGGRPPLSNVSGLVTVQVLD-INDNAPI-FVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            +D G P     S L  V + +   D  PI F    +  ++ E  P G +V  V+     +
Sbjct: 348  KDKGSP--QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL----S 401

Query: 535  GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
             +   +EY+L+       F IN  +G I  A  L+  + + Y   V  ++         A
Sbjct: 402  PEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL-----KA 456

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNT 652
             V++++ D ND+ P F QP Y   +NE   VGTSV+TVSA D+D   +  ITY I S   
Sbjct: 457  QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIAS--- 513

Query: 653  RNRFSITSQSGGGLVSLALPLDYKLERQ-YVLAVTASDG----TRQDTAQIVVNVTDANT 707
             N          G++S    LD++   + Y   V ASD       +    + + + + N 
Sbjct: 514  LNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVND 573

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAV 767
            + P+F+       ++ D P G  +  +SA D D  E  +      + +  F ++ D+G +
Sbjct: 574  NSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVL 633

Query: 768  TTQAEL--------------------DYEDQVSYTLAI----------TARDNGIPQK-S 796
              +  L                    +  D +S  +++          + R+  + QK +
Sbjct: 634  QLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLA 693

Query: 797  DTTYLEILVN---DVNDNAPQFLRDSYQG-----------SVYEDVPPFTSVLQISATDR 842
            +   ++   N   ++ D    F   + QG           +V ED+P   ++L+I A D 
Sbjct: 694  EKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDA 753

Query: 843  DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
            DSG NG+V +T   G+  D  F ++  +G ++ L  +DRE+   Y+L     D G P   
Sbjct: 754  DSGFNGKVLFTISDGNT-DSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812

Query: 903  TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
            +   +T+ V D NDN PVF QD + V + E+S IG  + +V A D D G+N ++ Y ++ 
Sbjct: 813  SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT 872

Query: 963  GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA-----TSAPLVSRATVHVRLLDRN 1017
                + F ++  +G +     LD E +  Y L I+A     +   L S  T+ V L D N
Sbjct: 873  DT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVN 930

Query: 1018 DNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELS-LVLL 1075
            D  P       + ++Y        P G  I  +  HDPD+       +   N+ +    +
Sbjct: 931  DCSPA-----FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEI 985

Query: 1076 NASTGELKLSRALD 1089
            + ++G ++LS+ LD
Sbjct: 986  DKASGAIRLSKELD 999



 Score =  173 bits (438), Expect = 3e-42
 Identities = 157/550 (28%), Positives = 253/550 (46%), Gaps = 44/550 (8%)

Query: 565  AAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAA 624
            +A L+RE  D Y   V+    G   L A   V++ VLD+ND  P F+   Y+V + E   
Sbjct: 114  SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172

Query: 625  VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
            + TSV  V+A D D  S   +     N  + FS+   SG  ++SL+  L+Y  + +Y L 
Sbjct: 173  LRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSG--VISLSGRLNYDEKNRYDLE 230

Query: 685  VTASDGTRQ--------DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISA 736
            + A D   +         TA++ V++   N H P      +     E  P    V +   
Sbjct: 231  ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDL 290

Query: 737  TDEDTGENARITYFMEDSIPQFRIDADTG-----AVTTQAELDYED-QVSYTLAITARDN 790
             D   GE   ++    D + QF +  +        +  + ++D+E     Y L + A+D 
Sbjct: 291  DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350

Query: 791  GIPQKSDTTYLEILVNDVNDNAP-QFLRDSYQGSVYEDVPP--FTSVLQISATDRDSGLN 847
            G PQK        + N   D  P +F ++ Y  S+ E  PP    +++++S    D    
Sbjct: 351  GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID---- 406

Query: 848  GRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEV 907
              V Y    G+D    F +   SG++ T R L+      Y L     +  +       +V
Sbjct: 407  --VEYKLSPGEDAVY-FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA-----QV 458

Query: 908  TVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPE 967
            T+++ D ND+ P F+Q  +D +V E+ P+G +V  V+A+D D+G N  I Y I   N+  
Sbjct: 459  TISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP 518

Query: 968  VFQLDIFSGELTALVDLDYEDRPE-YVLVIQAT--SAPL--VSRATVHVRLLDRNDNPPV 1022
             F ++ F+G ++   +LD+E  PE Y  +++A+   +P    S   V +R+ + NDN P+
Sbjct: 519  -FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577

Query: 1023 LGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGE 1081
               FE +    V   S  FP GG I  V A D D  + + Y    GNEL    LN  +G 
Sbjct: 578  ---FEKVACQGVI--SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGV 632

Query: 1082 LKLSRALDNN 1091
            L+L ++L N+
Sbjct: 633  LQLKKSLTNS 642



 Score =  122 bits (306), Expect = 5e-27
 Identities = 129/513 (25%), Positives = 222/513 (43%), Gaps = 53/513 (10%)

Query: 610  FTQPEYTVRLNEDAAVGTSVVTVSAVDR---DAHSVITYQITSGNTRNRFS--------- 657
            FT   Y   + E++A  T V + S +     D    I Y+I SG+    F          
Sbjct: 43   FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADF 102

Query: 658  ----ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPV 711
                I ++ G   +     L+ +++  Y+L V  S       A   VN  V D N  RP+
Sbjct: 103  CFLRIRTKGGNSAI-----LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPL 157

Query: 712  FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQA 771
            F  + Y+V + E  P  T+V  ++ATD D G N    Y+ ++ +  F +   +G ++   
Sbjct: 158  FSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSG 217

Query: 772  ELDYEDQVSYTLAITARDNGIP-----QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826
             L+Y+++  Y L I A D G+        S T  L + +  +N++AP     ++     E
Sbjct: 218  RLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLE 277

Query: 827  DVPPFTSVLQISATDRDSGLNGRV-FYTFQGGDDGDGDFIVESTSGI----VRTLRRLDR 881
              P +  V   +  D D G NG +   +   GD  D  F+ +    +    ++  +++D 
Sbjct: 278  KEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDW 334

Query: 882  ENVAQ-YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV-FEQDEFDVFVEENSPIGLA 939
            E+    Y L   A DKG P   + ++         D  P+ FE++ +DV + E SP G+ 
Sbjct: 335  ESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVV 394

Query: 940  VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
            VA +    P+      + Y++  G     F+++  SG +     L+   +  Y L +   
Sbjct: 395  VA-IVKLSPEP---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK 450

Query: 1000 SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISD 1058
               L ++ T+ +   D ND+ P     + L++ YV   + S P G ++  V A D D  +
Sbjct: 451  EGDLKAQVTISIE--DANDHTPEFQ--QPLYDAYV---NESVPVGTSVLTVSASDKDKGE 503

Query: 1059 S--LTYSFERGNELSLVLLNASTGELKLSRALD 1089
            +  +TYS    N L  V +N  TG +  +  LD
Sbjct: 504  NGYITYSIASLNLLPFV-INQFTGVISTTEELD 535



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 87/337 (25%), Positives = 139/337 (41%), Gaps = 55/337 (16%)

Query: 1571 CPAKKNVCDSNTCHNGGTCVNQWDA---FSCECPLGFGGKSCAQEMANPQHFLGSSLVAW 1627
            CP   + C    C     CV+   +   F C+CP G  G+       +   F G+S + +
Sbjct: 3792 CPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS---FAGNSYIKY 3848

Query: 1628 HGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVE---GTGLQA 1684
                    + + L+L  RT Q++G+++   TR    I L++ +G +   ++   G G+  
Sbjct: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMY--TRANPCIILKIVDGKLWFQLDCGSGPGILG 3906

Query: 1685 SSLRLEPGRA-NDGDWHHAQLALGASGGPGHAILSFD--YGQQR----------AEGNL- 1730
             S     GRA NDG WH   L L  +       LS D  Y ++R           E ++ 
Sbjct: 3907 IS-----GRAVNDGSWHSVFLELNRN----FTSLSLDDSYVERRRAPLYFQTLSTESSIY 3957

Query: 1731 -GPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQ 1789
             G  +   ++ ++T   +      V  GF+GCL  V +++    + +   S  E + + +
Sbjct: 3958 FGALVQADNIRSLTDTRVTQ----VLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTE 4013

Query: 1790 ---GCSL-PDPCDSNPCPANSYCSN-DWDSYSCSCDPGYYGDNCTN---VCDLNPCEHQS 1841
               GC L PD C  +PC     C+      Y C+C   + G NC +    C  NPC +  
Sbjct: 4014 LKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGG 4073

Query: 1842 VCTRKPSAPHGYT--CECPPNYLGPYCETRIDQPCPR 1876
             C      P G T  C C     G  CE  I++ C R
Sbjct: 4074 SCD-----PIGNTFICNCKAGLTGVTCEEDINE-CER 4104



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 46/151 (30%), Positives = 63/151 (41%), Gaps = 29/151 (19%)

Query: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
            C R PC++   C  +                     P GG +C C   FTG  CE+E+  
Sbjct: 4025 CKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEITA 4063

Query: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGF 1351
            C+  PC   G C      + C C+ G TG  CE       C    C+NGG+CVN+  G F
Sbjct: 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDI--NECEREECENGGSCVNVF-GSF 4120

Query: 1352 KCDCPSGDFEKPYCQVTTRSFP----AHSFI 1378
             C+C  G +   YC +     P     HS++
Sbjct: 4121 LCNCTPG-YVGQYCGLRPVVVPNIQAGHSYV 4150



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 16/39 (41%), Positives = 22/39 (56%)

Query: 1571 CPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSC 1609
            C    N C+   C NGG+CVN + +F C C  G+ G+ C
Sbjct: 4095 CEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 19/58 (32%), Positives = 21/58 (36%), Gaps = 22/58 (37%)

Query: 1228 DDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYC 1285
            D N C RE CEN   CV+V                       G   C C PG+ G YC
Sbjct: 4098 DINECEREECENGGSCVNVF----------------------GSFLCNCTPGYVGQYC 4133



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 12/32 (37%), Positives = 16/32 (50%)

Query: 1797 CDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC 1828
            C+   C     C N + S+ C+C PGY G  C
Sbjct: 4102 CEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133



 Score = 32.0 bits (71), Expect = 9.2
 Identities = 16/57 (28%), Positives = 25/57 (43%), Gaps = 3/57 (5%)

Query: 1808 CSNDWDSYSCSCDPGYY-GDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLG 1863
            C   + +  C+C+ G   G N  + C   PC     C    ++   + C+CPP  LG
Sbjct: 3776 CPRFYRNVRCTCNGGLCPGSN--DPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLG 3830


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  444 bits (1142), Expect = e-124
 Identities = 341/980 (34%), Positives = 487/980 (49%), Gaps = 53/980 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F   SY+A+VPE+ P G  +  L+A D DEGE GR+ Y +  L  +  N F  +    
Sbjct: 1100 PIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI--LHGNHGNNF-RIHVSN 1156

Query: 239  GAVTTAEE-LDRETKSTHVFRVTAQDHGM-PRRSALATLTILVTDTNDHDPVFEQQEYKE 296
            G +      LDRE  S+HV  V A +H + P RS++  + + V D ND  PVF QQ+Y  
Sbjct: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSR 1215

Query: 297  -SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
              LRE   +G  V+ V+ATD D+     + YR+L G+ G     FEID  +G+I T   +
Sbjct: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK----FEIDESTGLIITVNYL 1271

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            D E   SY + V A+DQ   P       +V++++ ++ D A QFS   Y   + E++  G
Sbjct: 1272 DYETKTSYMMNVSATDQA--PPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALG 1329

Query: 416  APVLRVTASDRDKGSNAVVHYSIM-SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
              ++RV A   D  +     ++   S  A+  F +DA TG + V   +D E    YTL V
Sbjct: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA-TVLESVPLGYLVLHVQAIDAD 533
             A DGG    S V   +TV  LD NDN+P F  T   A ++ E  P+G  V  V+A D D
Sbjct: 1390 VADDGGPKVDSTVKVYITV--LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447

Query: 534  AGDNARLEYRLAGVGHDFPF---TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
            AG N ++ + LA       F   T N+  G + VA  LDREE+D Y   V A D GTP  
Sbjct: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507

Query: 591  TASASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
                 + VT+LD+NDN P    P  Y V +NE+   GT+VV V A DRD   +SV++Y I
Sbjct: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTD 704
            T GN    F +   SG  + +   P D + +  Y L  T  D    T   T  + V + D
Sbjct: 1568 TEGNKDMAFRMDRISGE-IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626

Query: 705  ANTHRPVFQSSHYTVNVNEDRPA-GTTVVLISATDEDTGENARITYFME--DSIPQFRID 761
             N + P+FQ  HY V ++E      T+++ I A D D G N  +TY +   + +  FRID
Sbjct: 1627 ENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRID 1686

Query: 762  ADTGAVTTQAELDYE-DQVSYTLAITARDNG---IPQKSDTTYLEILVNDVNDNAPQFLR 817
               G +T   ELDYE     YTL +TA D       + + TT + + VND+NDN P F R
Sbjct: 1687 RHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR 1746

Query: 818  DSYQGSV-YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
            D Y+G     +  P   V    A DRDSG NG+V Y+   GD   G+F++    G++R  
Sbjct: 1747 D-YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVR 1804

Query: 877  R--RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
            +   LDRE +A Y L   A D+GMPP  + M V + VLD+NDN PV      ++ + ENS
Sbjct: 1805 KDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS 1864

Query: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
            P+   VA V A+D D G NA++ + I  GN    F ++  +G +T    LD E  PEY L
Sbjct: 1865 PVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKL 1924

Query: 995  VIQATSAPLVSRAT------VHVRLLDRNDNPPVLGNFEI---LFNNYVTNRSSSFPGGA 1045
             I     P   R        + + L D NDN P+         +  N       +   G 
Sbjct: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPL---EAIMSVLV 1102
            I  + A D DI   +TY    G +  L  +N+STG + +   +  +R       +  +L+
Sbjct: 1985 ILALDA-DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLL 2042

Query: 1103 SDGVHSVTAQCALRVTIITD 1122
            ++ +  + +   L +TI+ D
Sbjct: 2043 AEDIGLLNSTAHLLITILDD 2062



 Score =  405 bits (1041), Expect = e-112
 Identities = 312/908 (34%), Positives = 457/908 (50%), Gaps = 85/908 (9%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLR----AIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
            P F   +YQA V EN PAGTP+  L     A+D D+     + Y    L  ++S   F +
Sbjct: 1957 PLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ---LLGAQSG-LFDI 2012

Query: 235  DPVTGAVTTAEE--LDRETKSTHVFRVT--AQDHGMPRRSALATLTILVTDTNDHDPVFE 290
            +  TG VT      +DRE  S  +  +   A+D G+   +A   +TIL  D ND+ P F 
Sbjct: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFS 2070

Query: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350
                   L EN   G+ VL V ATD D+  N  ++YR+  G+     + F I   +GVIR
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA----QDRFLIHLVTGVIR 2126

Query: 351  T-RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
                 +DREE ESY+LTV A+D+G  P   S TA V + ++D ND+ P+F      V V 
Sbjct: 2127 VGNATIDREEQESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVL 2184

Query: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-----------GNARGQFYLDAQTGALDV 458
            E   PG  +  +TA D D   N  + Y I+             N    F ++  TG++ V
Sbjct: 2185 ESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242

Query: 459  VSPLDYE--TTKEYTLRV--RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS---TPFQ 511
             SP++ E   T E TL V   A D     +S  +  +TV VLD+NDN P F     T + 
Sbjct: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302

Query: 512  ATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG-VGHDFPFTINNGTGWISVAAELDR 570
              +LE    G  ++ V A+D D G N  + Y L   V   +    ++  G +     +D 
Sbjct: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362

Query: 571  EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
            EEV + +F V A D+G+P   A   V + ++D+NDNNP F QP Y   + ED  VGT ++
Sbjct: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL 2422

Query: 631  TVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD- 689
            TV+A D D+ +    + + G+  ++F+I   +G   + +   LD + +  Y+L   A D 
Sbjct: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYILTALAKDN 2480

Query: 690  ------GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE 743
                    R+++ Q+V+ V D N  RP F    ++ +V E+ PAGT+V+ + ATD+D G 
Sbjct: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540

Query: 744  NARITYFME-DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE 802
            N  +TY +E   +  F +D D+G VTTQ  L  +    ++L + A D G P    TT L 
Sbjct: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLL 2598

Query: 803  ILVNDVNDNAPQFLRDSYQGSVY---EDVPPFTSVLQISATDRDSGLNGRVFYTF--QGG 857
            + V DVNDN P F+R    G++    E++P  ++V ++ ATD+D GLNG V Y+F    G
Sbjct: 2599 VEVIDVNDNRPVFVRPP-NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAG 2657

Query: 858  DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPMEVTVTVLDVND 916
            +     FI++  SG+++T +RLDRE+ A Y L   A D G P P  T   + V + D++D
Sbjct: 2658 NRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDD 2717

Query: 917  NPPVFEQ-----DEFDVF-VEENSPIGLAVARVT-ATDPDEGTNAQIMYQIVEGNIPEVF 969
            N P+F +      ++ +  V E+SP G  V  VT A D DEG NA + Y I  GN  + F
Sbjct: 2718 NEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNF 2777

Query: 970  QLDIFSGELTALVDLDYEDRPEYVLVIQATS-------------APLVSRAT---VHVRL 1013
             L    G L  L DLD E    +  +++A+S               LV+  T   V V L
Sbjct: 2778 HLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVL 2836

Query: 1014 LDRNDNPP 1021
             D ND PP
Sbjct: 2837 EDINDQPP 2844



 Score =  392 bits (1007), Expect = e-108
 Identities = 304/972 (31%), Positives = 461/972 (47%), Gaps = 58/972 (5%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVT 242
            P  Y  +V EN   GT V  +RA D D G    L Y +    +   +  F +D ++G + 
Sbjct: 1530 PFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT---EGNKDMAFRMDRISGEIA 1586

Query: 243  TAEEL-DRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
            T     DRE +S +    T +D G P  SA   + + + D ND+ P+F+Q  Y+  L E 
Sbjct: 1587 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646

Query: 302  LE-VGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360
             + +   ++T++A D D  PN  + Y ++    G+    F ID   GVI     +D E  
Sbjct: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAIV---AGNIVNTFRIDRHMGVITAAKELDYEIS 1703

Query: 361  ES-YQLTVEASDQGRDPGPRST-TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
               Y L V A+DQ      R T T  V ++V D NDN P F           +  PG  V
Sbjct: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763

Query: 419  LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYETTKEYTLRVRA 476
                A DRD G N  V YSIM G+  G+F +    G L V     LD ET   Y L + A
Sbjct: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
            +D G PPLS+   LV ++VLDINDN P+ ++ P   T+ E+ P+   V HV A DAD+G 
Sbjct: 1824 RDRGMPPLSSTM-LVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
            NARL + +     +  F IN  TG ++V   LDRE +  Y   +  +D+      A    
Sbjct: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942

Query: 597  SVTVL---DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA------VDRDAHSVITYQI 647
             + ++   D NDN+P FT+  Y   + E++  GT +  ++        D+D ++V+TYQ+
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT--ASD-GTRQDTAQIVVNVTD 704
              G     F I S +G   V   + +D +     +L +   A D G    TA +++ + D
Sbjct: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061

Query: 705  ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDAD 763
             N +RP F  +  TV++ E+ P G +V+ ++ATDED+G N  + Y +E     +F I   
Sbjct: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLV 2121

Query: 764  TGAVTT-QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
            TG +    A +D E+Q SY L + A D G    S T  + IL++D+ND+ P+FL      
Sbjct: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181

Query: 823  SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG---GDDGD-------GDFIVESTSGI 872
            SV E   P T +  I+A D D  LN ++ Y   G    DD D         F V   +G 
Sbjct: 2182 SVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239

Query: 873  VRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPM----EVTVTVLDVNDNPPVFEQDEFD 927
            V     ++RE VA Y +    +D     P R+      ++TV VLDVNDN P F+     
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299

Query: 928  VFVE---ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQL-DIFSGELTALVD 983
             ++E   E +  G  +  V A DPD+G N  + Y +++   P   QL D  +G++ A   
Sbjct: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359

Query: 984  LDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSS 1040
            +DYE+       ++A+   S P  +   V++ ++D NDN P+         +Y       
Sbjct: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ-----PSYQEAVFED 2414

Query: 1041 FPGGAIG-RVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMS 1099
             P G I   V A D D  +     +  G+  S   +N +TG++ +  +LD  +    I++
Sbjct: 2415 VPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILT 2474

Query: 1100 VLVSDGVHSVTA 1111
             L  D    V +
Sbjct: 2475 ALAKDNPGDVAS 2486



 Score =  390 bits (1001), Expect = e-107
 Identities = 316/996 (31%), Positives = 469/996 (47%), Gaps = 58/996 (5%)

Query: 165  ESLGGRRKRNV----NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM 220
            E   GR + NV    +  P FQ  +Y   + EN+P+ T +  LRA D D     ++ Y++
Sbjct: 541  EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600

Query: 221  DALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVT--AQDHGMPRRSALATLTIL 278
             +     S    SL    G ++ +  LD E  S  +  +T  A D G P  ++   +TI 
Sbjct: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660

Query: 279  VTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPN---ANILYRLLEGSGGS 335
            V D ND+ P F +  Y  S+ EN+  G  VL + ATD D        +I+Y L EGS   
Sbjct: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGS--- 716

Query: 336  PSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN 395
                F I+ RSG I T   +DRE    Y L V A D G     ++  A V +++ D NDN
Sbjct: 717  --TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDN 774

Query: 396  APQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTG 454
             P + +  Y + + E   P + V  V A D D G N  + YSI   N   +FY L++ TG
Sbjct: 775  HPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTG 831

Query: 455  A-------LDVVSPLDYETTKEYTLRVRAQDGGRPPL-SNVSGLVTVQVLDINDNAPIFV 506
                    LD  +P  +E      + V   D GRPPL +  S  V V +LD+NDN P F 
Sbjct: 832  KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891

Query: 507  STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA 566
            + PF A VLE +P G  +  V AID D G N  + YR+        F IN+ +G +    
Sbjct: 892  NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951

Query: 567  ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG 626
            ELDRE +  Y   V A D GTP  ++++++++ VLDVND  PTF    Y V ++ED    
Sbjct: 952  ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011

Query: 627  TSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
              VV ++  D D   ++ ++Y IT GN   +FS+  +    +V   + LD +    Y+L 
Sbjct: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRD--AVVRTVVGLDRETTAAYMLI 1069

Query: 685  VTASD----GTRQ-DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDE 739
            + A D    G R   TA + V V D N +RP+F  S Y  +V ED P G +++ + ATD 
Sbjct: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129

Query: 740  DTGENARITY--FMEDSIPQFRIDADTGAVTT-QAELDYEDQVSYTLAITARDNGIPQKS 796
            D GE  R+ Y     +    FRI    G +      LD E   S+ L + A ++ +    
Sbjct: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR 1189

Query: 797  DTTYLEILVNDVNDNAPQFLRDSYQG-SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
             +  + + V D+ND AP F +  Y    + E     TSV+ + ATDRDSG  G V Y   
Sbjct: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249

Query: 856  GGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVN 915
             G   +G F ++ ++G++ T+  LD E    Y++   A D+  P  +    V +T+L+  
Sbjct: 1250 SG--AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307

Query: 916  DNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI---VEGNIPEVFQLD 972
            D    F    ++  + EN  +G  + RV A   D     QI Y+           +F++D
Sbjct: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKALFKID 1365

Query: 973  IFSGELTALVDLDYEDRPEYVLVIQA-TSAPLV-SRATVHVRLLDRNDNPPVLGNFEILF 1030
              +G +T    +D E    Y L + A    P V S   V++ +LD NDN P    F+   
Sbjct: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTS 1422

Query: 1031 NNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFERGN---ELSLVLLNASTGELKLS 1085
            ++ V+       G  +  V A DPD   +  + +S   GN      +V  N S GE+ ++
Sbjct: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482

Query: 1086 RALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
            R LD       I+ V+ SD G         L+VTI+
Sbjct: 1483 RPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518



 Score =  388 bits (997), Expect = e-107
 Identities = 306/980 (31%), Positives = 475/980 (48%), Gaps = 79/980 (8%)

Query: 174  NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
            NV T P+     ++ T  E QP G  V +  A D D G  G++EY+   + D      F 
Sbjct: 1740 NVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYS---IMDGDPLGEFV 1793

Query: 234  LDPVTGAVTTAE--ELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291
            + PV G +   +  ELDRET + +   + A+D GMP  S+   + I V D ND+DPV   
Sbjct: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853

Query: 292  QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
                 ++ EN  V   V  V A+D D+  NA + + +   + G+    F I+  +G++  
Sbjct: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGIVTV 1910

Query: 352  RGPVDREEVESYQLTVEASDQGRDPG-PRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRE 410
              P+DRE +  Y+LT+   D   +P   R     + + + D+NDN P F++  Y  +V E
Sbjct: 1911 NRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVME 1970

Query: 411  DVTPGAPVL----RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDY 464
            +   G P+      + A D D+   AVV Y ++ G   G F +++ TG + V S   +D 
Sbjct: 1971 NSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDR 2029

Query: 465  ETTKEYTLRVR--AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522
            E      L +   A+D G   L N +  + + +LD NDN P F        +LE+ P G+
Sbjct: 2030 EAFSPPILELLLLAEDIG---LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086

Query: 523  LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVA-AELDREEVDFYSFGVE 581
             VL V A D D+G N  L YR+     D  F I+  TG I V  A +DREE + Y   V 
Sbjct: 2087 SVLQVTATDEDSGLNGELVYRIEAGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145

Query: 582  ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS 641
            A D GT  L+ +A V++ + D+ND+ P F  P  TV + E A  GT +  ++A+D D + 
Sbjct: 2146 ATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP 2205

Query: 642  VITYQITS-----------GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG 690
             + Y I              N  + F++   +G  +V    P++ +L   Y + ++  D 
Sbjct: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELVATYEVTLSVIDN 2263

Query: 691  TRQ--------DTAQIVVNVTDANTHRPVFQS---SHYTVNVNEDRPAGTTVVLISATDE 739
                         A++ VNV D N + P F+    ++Y   + E    GTT++ ++A D 
Sbjct: 2264 ASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDP 2323

Query: 740  DTGENARITYFMEDSIPQFRI---DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKS 796
            D G N  +TY + D +P   +   D+  G V     +DYE+       + A DNG P ++
Sbjct: 2324 DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRA 2383

Query: 797  DT--TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
                 YLEI+  D+NDN P F + SYQ +V+EDVP  T +L ++ATD DSG    + Y+ 
Sbjct: 2384 AEIPVYLEIV--DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441

Query: 855  QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA----RTPMEVTVT 910
                DG+  F +  T+G +  L  LDRE    Y+L A A D     A       ++V + 
Sbjct: 2442 ---GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498

Query: 911  VLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQ 970
            VLDVND  P F + +F   V EN P G +V  + ATD DEG N ++ Y + EG   E F 
Sbjct: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFH 2557

Query: 971  LDIFSGELTALVDLD-YEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVL---GNF 1026
            +D+ SG +T    L  YE     V+       PL     + V ++D NDN PV     N 
Sbjct: 2558 VDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617

Query: 1027 EIL-FNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER--GN-ELSLVLLNASTGEL 1082
             IL     +  RS+ +   A  +    D  ++ ++ YSF +  GN +    +++  +G +
Sbjct: 2618 TILHIREEIPLRSNVYEVYATDK----DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673

Query: 1083 KLSRALDNNRPLEAIMSVLV 1102
            + ++ LD  R  +A+ S+++
Sbjct: 2674 QTAQRLD--RESQAVYSLIL 2691



 Score =  388 bits (996), Expect = e-107
 Identities = 316/984 (32%), Positives = 471/984 (47%), Gaps = 78/984 (7%)

Query: 190  VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
            + E+ P G+ V  L A D D       +  +  +    +++FF+++P TG V   + LDR
Sbjct: 42   ISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95

Query: 250  ETKSTHVFRVTAQDH-GMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEV 308
            ETKS      +  DH G+  R     + I V D ND+ P F  Q Y   + EN  VG  +
Sbjct: 96   ETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151

Query: 309  LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
              V ATD D     ++LY     S   PS+ F ID   G++     +D E  ++YQLTV 
Sbjct: 152  FIVNATDPDLGAGGSVLY-----SFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206

Query: 369  ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428
            A+DQ +   P ST A + + + D  D  P F    Y   + E   PG  V  +TA D+DK
Sbjct: 207  ATDQDK-TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265

Query: 429  GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET---TKEYTLRVRA---QDGGRP 482
            G    + Y+I+SGN    F LD  +G L +   LD E    +  + L V+     D   P
Sbjct: 266  GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY-LVLHVQAIDAD--AGDNAR 539
              + V+    + V+DINDNAP F S+ +   + E   +G+ L L +Q +D D   G N+ 
Sbjct: 326  SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385

Query: 540  LEYRLAG-VGHDFPFTINNGTG----WISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
             E  L G   H F  +  +  G     I VA  LD E VD Y F + A +   P     A
Sbjct: 386  FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYA 444

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN 654
             V +T+++ NDN P F+QP Y + L E+  VGTSV+TV A D DA +         +  +
Sbjct: 445  KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD 504

Query: 655  RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-TAQIVVNVTDANTHRPVFQ 713
            RFS+   +  GL+ L   LDY+L +++ L + A DG  ++ T ++ +NV D N + P FQ
Sbjct: 505  RFSLDKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQ 562

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-----SIPQFRIDADTGAVT 768
               Y   + E+ P+ T +V + ATDED+  N +ITY +       S     +    G ++
Sbjct: 563  KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVIS 622

Query: 769  TQAELDYEDQVS---YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
                LDYE Q+S     L + A D G P  + T  + I V D NDN P F + +Y  SV 
Sbjct: 623  VSRPLDYE-QISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681

Query: 826  EDVPPFTSVLQISATDRDSGL---NGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
            E++    +VL ++ATD D         + Y+ +G       F + + SG + T   LDRE
Sbjct: 682  ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSLLDRE 737

Query: 883  NVAQYVLRAYAVDKGMPPARTP--MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940
              ++Y+L   AVD G+   +      V +T+LD+NDN P ++   + + + E +P    V
Sbjct: 738  TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797

Query: 941  ARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVDLDYEDRPEYVL--- 994
              V A DPD G N  ++Y I   N  + + L+  +G++    A++D +  D  E  L   
Sbjct: 798  TTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855

Query: 995  -VIQATSA---PL--VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIG 1047
             V+  T     PL   S ATV V LLD NDN P   N       +V       P G +I 
Sbjct: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----FVAEVLEGIPAGVSIY 910

Query: 1048 RVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +V A D D  ++  ++Y    G      L+N+S+G +  +  LD  R  E  + V+ SD 
Sbjct: 911  QVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDA 970

Query: 1106 ---VHSVTAQCALRVTIITDEMLT 1126
                 S T+   + V  + DE  T
Sbjct: 971  GTPTKSSTSTLTIHVLDVNDETPT 994



 Score =  385 bits (990), Expect = e-106
 Identities = 312/984 (31%), Positives = 465/984 (47%), Gaps = 57/984 (5%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS-LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
            + AP+F    Y   + E    G  +   ++ +D DE     L    +      ++  F +
Sbjct: 343  DNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG--LNSMFEVYLVGNNSHHFII 400

Query: 235  DPVTGA------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
             P +        +  A  LD ET   + F + A +  +P     A + I + + ND+ P+
Sbjct: 401  SPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPI 459

Query: 289  FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
            F Q  Y  SL EN+ VG  VLTV ATD DA     + Y           + F +D  +G+
Sbjct: 460  FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLDKDTGL 514

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
            I     +D E ++ + LT+ A    RD G   TT  V ++V D NDN P F +  YV  +
Sbjct: 515  IMLIARLDYELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570

Query: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY---LDAQTGALDVVSPLDYE 465
            RE+      ++R+ A+D D   N  + YSI+S +A G ++   L    G + V  PLDYE
Sbjct: 571  RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630

Query: 466  TTKE--YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523
                    L V A D G PPL N +  VT++V D NDN P F    +  +V+E++  G  
Sbjct: 631  QISNGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689

Query: 524  VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
            VL + A D D       E  +  +     F IN  +G I+  + LDRE    Y   V A 
Sbjct: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749

Query: 584  DHGT--PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--A 639
            D G      T  A+V++T+LD+NDN+PT+    Y + L E     + V TV AVD D   
Sbjct: 750  DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE 809

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLAL-------PLDYKLERQYVLAVTASDG-- 690
            +  + Y I   N    +S+ S +G    + A+       P + +L R+ V++VT      
Sbjct: 810  NGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867

Query: 691  -TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
                 +A + VN+ D N + P FQ+  +   V E  PAG ++  + A D D G N  ++Y
Sbjct: 868  LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927

Query: 750  FMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVND 807
             M   +P+  F I++ +G V T  ELD E    Y L + A D G P KS T+ L I V D
Sbjct: 928  RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987

Query: 808  VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVE 867
            VND  P F    Y  SV EDVP    V+ ++ TD D GLN  + Y   GG + DG F V 
Sbjct: 988  VNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGG-NVDGKFSVG 1046

Query: 868  STSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT--VTVLDVNDNPPVFEQDE 925
                +VRT+  LDRE  A Y+L   A+D G    R     T  VTVLDVNDN P+F Q  
Sbjct: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106

Query: 926  FDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDL 984
            ++  V E+ P G ++ ++ ATD DEG   ++ Y+I+ GN    F++ + +G L      L
Sbjct: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166

Query: 985  DYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSF 1041
            D E    +VL+++A +    P+ S   V V + D ND  PV    +    + +  R ++ 
Sbjct: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY---SRLGLRETAG 1223

Query: 1042 PGGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMS 1099
             G ++  V A D D  D   + Y    G E     ++ STG +     LD       +M+
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMN 1282

Query: 1100 VLVSDGVHSVT-AQCALRVTIITD 1122
            V  +D         C++ +T++ +
Sbjct: 1283 VSATDQAPPFNQGFCSVYITLLNE 1306



 Score =  370 bits (949), Expect = e-101
 Identities = 291/898 (32%), Positives = 432/898 (48%), Gaps = 65/898 (7%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + AP F    Y   +PEN P GTP+  + A DPD G  G + Y+         +QFF++D
Sbjct: 127  DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP-----PSQFFAID 181

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPR-RSALATLTILVTDTNDHDPVFEQQEY 294
               G VT   ELD ET   +   V A D    R  S LA L I++TD  D DP+F    Y
Sbjct: 182  SARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPY 241

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
              ++ E+   G  V  + A D D      I Y ++ G+  S   +F +D  SGV+   G 
Sbjct: 242  STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS---IFALDYISGVLTLNGL 298

Query: 355  VDREE---VESYQLTVEASD--QGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
            +DRE       + LTV+ ++    R P   + T    + V D NDNAP+F+   Y V + 
Sbjct: 299  LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAIT 358

Query: 410  EDVTPGAPV---LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALD----VVS 460
            E    G  +   ++V   D + G N++    ++ GN    F +   +  G  D    V  
Sbjct: 359  ELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAI 417

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
            PLDYET   Y   + A +     +      V + +++ NDN PIF    +  ++ E+V +
Sbjct: 418  PLDYETVDRYDFDLFANESVPDHVGYAK--VKITLINENDNRPIFSQPLYNISLYENVTV 475

Query: 521  GYLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSF 578
            G  VL V A D DAG    + Y  +    D P  F+++  TG I + A LD E +  ++ 
Sbjct: 476  GTSVLTVLATDNDAGTFGEVSYFFS----DDPDRFSLDKDTGLIMLIARLDYELIQRFTL 531

Query: 579  GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
             + ARD G    T    V + VLDVNDN PTF +  Y   L E+    T +V + A D D
Sbjct: 532  TIIARDGGGEETT--GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589

Query: 639  A--HSVITYQITSGNT-RNRFSITSQSGGGLVSLALPLDYK-----LERQYVLAVTASDG 690
            +  ++ ITY I S +   + F I+   G G++S++ PLDY+     L    V+A+ A + 
Sbjct: 590  SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP 649

Query: 691  TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE---NARI 747
                T  + + V D N + P F    Y V+V E+  AG TV+ ++ATD D         I
Sbjct: 650  PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI 709

Query: 748  TYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI--PQKSDTTYLEILV 805
             Y +E S  QFRI+A +G +TT + LD E +  Y L + A D G+   QK+    + I +
Sbjct: 710  IYSLEGS-TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITL 768

Query: 806  NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865
             D+NDN P +    Y  ++ E  PP + V  + A D D G NG + Y+ Q     +  + 
Sbjct: 769  LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---PPNKFYS 825

Query: 866  VESTSGIVRTLR-RLDRENVAQY---VLRAYAV---DKGMPPARTPMEVTVTV--LDVND 916
            + ST+G +RT    LDREN   +   ++R   V   D G PP +     TV V  LD+ND
Sbjct: 826  LNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885

Query: 917  NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSG 976
            N P F+   F   V E  P G+++ +V A D DEG N  + Y++  G     F ++  SG
Sbjct: 886  NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 945

Query: 977  ELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFN 1031
             +    +LD E   EY L + A+ A      S +T+ + +LD ND  P    F  ++N
Sbjct: 946  VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1001



 Score =  342 bits (877), Expect = 3e-93
 Identities = 297/982 (30%), Positives = 464/982 (47%), Gaps = 76/982 (7%)

Query: 176  NTAPQFQPPSYQATVPEN-QPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
            + AP FQ P Y+  + E      T + +++A+D DEG  G + Y   A+        F +
Sbjct: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRI 1685

Query: 235  DPVTGAVTTAEELDRE-TKSTHVFRVTAQDHG---MPRRSALATLTILVTDTNDHDPVFE 290
            D   G +T A+ELD E +   +   VTA D       R ++  T+ + V D ND+ P F 
Sbjct: 1686 DRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP 1745

Query: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350
            +           + G  V T  A D D+ PN  + Y +++   G P   F I P  GV+R
Sbjct: 1746 RDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMD---GDPLGEFVISPVEGVLR 1802

Query: 351  TRGPV--DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
             R  V  DRE +  Y LT+ A D+G    P S+T  V + V D NDN P        + +
Sbjct: 1803 VRKDVELDRETIAFYNLTICARDRGMP--PLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860

Query: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
             E+    + V  V ASD D G NA + ++I +GN    F+++A TG + V  PLD E   
Sbjct: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920

Query: 469  EYTLRVRAQDGGRPP--LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG--YLV 524
            EY L +  +D    P        L+ + + D NDN P+F  + +QA V+E+ P G    V
Sbjct: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980

Query: 525  LH--VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVD--FYSF 578
            L+  + A+DAD    A + Y+L G      F IN+ TG ++V +   +DRE         
Sbjct: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILEL 2039

Query: 579  GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
             + A D G   L ++A + +T+LD NDN PTF+    TV L E+   G SV+ V+A D D
Sbjct: 2040 LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED 2097

Query: 639  A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GT--RQ 693
            +  +  + Y+I +G  ++RF I   +G   V  A  +D + +  Y L V A+D GT    
Sbjct: 2098 SGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVATDRGTVPLS 2155

Query: 694  DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED 753
             TA + + + D N  RP F +   TV+V E    GT +  I+A D D   N ++ Y +  
Sbjct: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVG 2213

Query: 754  SIPQ-------------FRIDADTGAVTTQAELDYEDQVSYTLAITARDNG--IPQKS-- 796
             + +             F ++ +TG+V  ++ ++ E   +Y + ++  DN   +P++S  
Sbjct: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS 2273

Query: 797  -DTTYLEILVNDVNDNAPQFLR---DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFY 852
                 L + V DVNDN PQF       Y   + E   P T+++ ++A D D GLNG V Y
Sbjct: 2274 VPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333

Query: 853  TFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
            T           + +S++G V   R +D E V        A D G PP    + V + ++
Sbjct: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393

Query: 913  DVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD 972
            D+NDN P+F+Q  +   V E+ P+G  +  VTATD D G  A I Y + +G     F ++
Sbjct: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAIN 2451

Query: 973  IFSGELTALVDLDYEDRPEYVLVIQATSAP-------LVSRATVHVRLLDRNDNPPVLGN 1025
              +G++  L  LD E +  Y+L   A   P         +   V +++LD ND  P    
Sbjct: 2452 PTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK 2511

Query: 1026 FEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELK 1083
             +   + Y    +    G ++  + A D D   +  LTYS E G  +    ++  +G + 
Sbjct: 2512 PQFSTSVYENEPA----GTSVITMMATDQDEGPNGELTYSLE-GPGVEAFHVDMDSGLVT 2566

Query: 1084 LSRALDNNRPLEAIMSVLVSDG 1105
              R L +       ++V+ +DG
Sbjct: 2567 TQRPLQSYEKFS--LTVVATDG 2586



 Score =  329 bits (844), Expect = 2e-89
 Identities = 263/836 (31%), Positives = 403/836 (48%), Gaps = 69/836 (8%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P +    + EN P G  V  + A D D G  G L Y ++A    R    F +  VT
Sbjct: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVT 2122

Query: 239  GAVTTAEE-LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
            G +      +DRE + ++   V A D G    S  A +TIL+ D ND  P F       S
Sbjct: 2123 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2182

Query: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLL--------EGSGGSPSEVFEIDPRSGVI 349
            + E+ E G  +  + A D D  P     Y ++        +    +  + F ++  +G +
Sbjct: 2183 VLESAEPGTVIANITAIDHDLNPKLE--YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2240

Query: 350  RTRGPVDREEVESYQLTVEASDQGRDPGPRSTT---AAVFLSVEDDNDNAPQFSE---KR 403
              + P++RE V +Y++T+   D   D   RS +   A + ++V D NDN PQF       
Sbjct: 2241 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300

Query: 404  YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYL-DAQTGALDVVSPL 462
            Y+ ++ E  TPG  ++ V A D DKG N +V Y+++     G   L D+  G +     +
Sbjct: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360

Query: 463  DYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522
            DYE        VRA D G PP +     V ++++DINDN PIF    +Q  V E VP+G 
Sbjct: 2361 DYEEVHWLNFTVRASDNGSPPRA-AEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419

Query: 523  LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEA 582
            ++L V A DAD+G+ A +EY L G G    F IN  TG I V + LDRE+ D Y     A
Sbjct: 2420 IILTVTATDADSGNFALIEYSL-GDGES-KFAINPTTGDIYVLSSLDREKKDHYILTALA 2477

Query: 583  RDHGTPALTA----SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
            +D+     +     S  V + VLDVND  P F++P+++  + E+   GTSV+T+ A D+D
Sbjct: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537

Query: 639  A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-- 694
               +  +TY +  G     F +   SG  LV+   PL  +   ++ L V A+DG      
Sbjct: 2538 EGPNGELTYSL-EGPGVEAFHVDMDSG--LVTTQRPL--QSYEKFSLTVVATDGGEPPLW 2592

Query: 695  -TAQIVVNVTDANTHRPVF--QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-F 750
             T  ++V V D N +RPVF    +   +++ E+ P  + V  + ATD+D G N  + Y F
Sbjct: 2593 GTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF 2652

Query: 751  MEDSIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY-LEILV 805
            ++ +  +    F ID  +G + T   LD E Q  Y+L + A D G P   +T   L++ +
Sbjct: 2653 LKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVAL 2712

Query: 806  NDVNDNAPQFLRDSYQGSVY------EDVPPFTSVLQIS-ATDRDSGLNGRVFYTFQGGD 858
             D++DN P F+R       Y      E  P  T V  ++ A D D G N  V+Y    G+
Sbjct: 2713 EDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN 2772

Query: 859  DGDGDFIVESTSGIVRTLRRLDRENVA--QYVLRAYAVDKGMPPAR-----------TPM 905
            + + +F ++   G +  LR LDRE  A   ++++A +     PP             T  
Sbjct: 2773 E-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830

Query: 906  EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961
            EV V + D+ND PP F + E+   V  ++ +G  + +V A D D G N+ + Y I+
Sbjct: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886



 Score =  258 bits (658), Expect = 8e-68
 Identities = 236/820 (28%), Positives = 368/820 (44%), Gaps = 85/820 (10%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM---------DALFDS 226
            ++ P+F  P    +V E+   GT +A++ AID D     +LEY +         D L  +
Sbjct: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLVPN 2226

Query: 227  RSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHG--MPRRSAL---ATLTILVTD 281
            + +  F+++  TG+V     ++RE  +T+   ++  D+   +P RS     A LT+ V D
Sbjct: 2227 QEDA-FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285

Query: 282  TNDHDPVFEQ---QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE 338
             ND+ P F+      Y E + E    G  ++ V A D D   N  + Y LL+     P  
Sbjct: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLV--PPGY 2343

Query: 339  VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398
            V   D  +G +     VD EEV     TV ASD G    PR+    V+L + D NDN P 
Sbjct: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP--PRAAEIPVYLEIVDINDNNPI 2401

Query: 399  FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV 458
            F +  Y   V EDV  G  +L VTA+D D G+ A++ YS+  G+   +F ++  TG + V
Sbjct: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYV 2459

Query: 459  VSPLDYETTKEYTLRVRAQDGGRPPLSN---VSGLVTVQVLDINDNAPIFVSTPFQATVL 515
            +S LD E    Y L   A+D      SN    S  V +QVLD+ND  P F    F  +V 
Sbjct: 2460 LSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVY 2519

Query: 516  ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDF 575
            E+ P G  V+ + A D D G N  L Y L G G +  F ++  +G ++    L  +  + 
Sbjct: 2520 ENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEK 2576

Query: 576  YSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPE--YTVRLNEDAAVGTSVVTVS 633
            +S  V A D G P L  +  + V V+DVNDN P F +P     + + E+  + ++V  V 
Sbjct: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636

Query: 634  AVDRD--AHSVITYQI--TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD 689
            A D+D   +  + Y    T+GN    F I      GL+  A  LD + +  Y L + ASD
Sbjct: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI-SGLIQTAQRLDRESQAVYSLILVASD 2695

Query: 690  ---GTRQDTAQ-IVVNVTDANTHRPVF------QSSHYTVNVNEDRPAGTTVVLIS-ATD 738
                   +T Q + V + D + + P+F         +  + V E  P GT V  ++ A D
Sbjct: 2696 LGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVD 2755

Query: 739  EDTGENARITYFME--DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDN--GIPQ 794
             D G NA + YF+   +    F +  D G +    +LD E +  ++  + A  N    P 
Sbjct: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPP 2814

Query: 795  KSDTTYLE-----------ILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
            +  +  L+           +++ D+ND  P+F +  Y   V  D    + ++Q+ A D D
Sbjct: 2815 RGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDAD 2874

Query: 844  SGLNGRVFYTF----------QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
             G N  VFY+              +D    F + S  GI+RT       +   +V+   A
Sbjct: 2875 IGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVA 2934

Query: 894  VDK---------GMPPARTPMEVTVTVLDVNDNPPVFEQD 924
             D          G+   R    V + + ++ D    FE++
Sbjct: 2935 RDLAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEE 2974



 Score =  181 bits (459), Expect = 9e-45
 Identities = 152/572 (26%), Positives = 260/572 (45%), Gaps = 34/572 (5%)

Query: 619  LNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678
            ++ED  VG+SV  + A D D   ++     SG   +RF    +   G+V L  PLD + +
Sbjct: 42   ISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRF-FAVEPDTGVVWLRQPLDRETK 98

Query: 679  RQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
             ++ +  + SD     T ++ + V D N + P F +  Y+V + E+ P GT + +++ATD
Sbjct: 99   SEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATD 158

Query: 739  EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
             D G    + Y  +     F ID+  G VT   ELDYE   +Y L + A D    +   T
Sbjct: 159  PDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218

Query: 799  -TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGG 857
               L I++ DV D  P F+   Y  ++YE  PP T+V  I+A D+D G    + YT   G
Sbjct: 219  LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278

Query: 858  DDGDGDFIVESTSGIVRTLRRLDRENVAQ---YVLRAYAVDKGMPPARTPMEVTVT---- 910
            +  +  F ++  SG++     LDREN      ++L     +  +   RTP + TVT    
Sbjct: 279  NT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE--LNDDRTPSDATVTTTFN 335

Query: 911  --VLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR-VTATDPDEGTNAQIMYQI-VEGNIP 966
              V+D+NDN P F   E+ V + E + +G A+   +   D DE      M+++ + GN  
Sbjct: 336  ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395

Query: 967  EVFQLDIFSGE------LTALVDLDYE--DRPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
              F +   S +      +   + LDYE  DR ++ L    +    V  A V + L++ ND
Sbjct: 396  HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455

Query: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078
            N P+    + L+N  ++   +   G ++  V A D D       S+   ++     L+  
Sbjct: 456  NRPIFS--QPLYN--ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511

Query: 1079 TGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIITDEMLTHSITLRLEDMS 1137
            TG + L   LD        ++++  D G    T +  + V  + D + T      +  + 
Sbjct: 512  TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL- 570

Query: 1138 PERFLSPLLGLFIQAVAATLATPPDHVVVFNV 1169
              R   P +   ++  A    +PP++ + +++
Sbjct: 571  --RENEPSVTQLVRLRATDEDSPPNNQITYSI 600


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  425 bits (1092), Expect = e-118
 Identities = 317/943 (33%), Positives = 473/943 (50%), Gaps = 63/943 (6%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            AP F  P+Y   VPE+ PAGT +  L+A DPD G  G + Y + A     +   F L+P 
Sbjct: 1852 APAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFLLEPS 1907

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMPRR-SALATLTILVTDTNDHDPVFEQQEYKE 296
            +G + TA  LDRE   ++ F V+A D       S   ++TI V D NDH P F     + 
Sbjct: 1908 SGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL 1967

Query: 297  SL-RENLEVGYEVL---TVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT- 351
             L R         L   T+RA D DA  NA+ILYRL     G+P     +D  +G IR  
Sbjct: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL----AGTPPPGTTVDSYTGEIRVA 2023

Query: 352  RGPV---DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
            R PV    R+ V    L + A+D GR    RS T  + + ++ + +  P+F        +
Sbjct: 2024 RSPVALGPRDRV----LFIVATDLGRPA--RSATGVIIVGLQGEAERGPRFPRASSEATI 2077

Query: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYET 466
            RE+  PG P++   A     G+N  + YSI+SGN +G F +   TGA+ V S   LD+E 
Sbjct: 2078 RENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEV 2136

Query: 467  TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
            +    L ++A+ GG    +    ++T+ + D NDNAP F+   + A + ES PL   +L 
Sbjct: 2137 SPRLRLVLQAESGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQ 2192

Query: 527  VQAIDADAGDNARLEYRLAGVGHDFP-FTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
            V+A D D G   ++ Y LA        F ++  TG I+  A LDRE        + A D 
Sbjct: 2193 VEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDR 2252

Query: 586  GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITY 645
            G+PAL  SA+++V V+D NDN PT  QP + +R++EDA +G+ +  V+  D D+  V+ Y
Sbjct: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWY 2311

Query: 646  QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDA 705
             ++    ++ FS+     GG VSL  PLD++   +Y L + A DG  +  A + V V D 
Sbjct: 2312 VLSPSGPQDPFSVGRY--GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDV 2369

Query: 706  NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG 765
            N + P F  S Y V + E  P G+ ++ +SATD D+G N  I+Y +      F +D + G
Sbjct: 2370 NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNG 2429

Query: 766  AVTT---QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
             + T      L ++   +  + + ARD+G P ++    + + + D ND+AP F    Y+ 
Sbjct: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489

Query: 823  SVYEDVPPFTSVLQISATDRD-------------SGLNGRVFYTFQG-GDDGDGDFIVES 868
            +V ED+PP +++L + ATD D             SG  GRVF       + G+       
Sbjct: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPR 2549

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
              G +  L  LD E++ QY L   A D+G PP  + + VTVTVLDVNDNPPVF +  + V
Sbjct: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRV 2609

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             V E++P+G  +  V A+D D G +  + + +  G+   +F+LD  SG L     LD E 
Sbjct: 2610 TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET 2669

Query: 989  RPEYVLVIQAT--SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAI 1046
            +  + LV+QA   +    + A V + + D ND+ P      +L  +   N+    PG  +
Sbjct: 2670 QARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF-PLNLLSTSVAENQP---PGTLV 2725

Query: 1047 GRVPAHDPDIS--DSLTYS-FERG---NELSLVLLNASTGELK 1083
              + A D D      L YS  E G          LN+STGEL+
Sbjct: 2726 TTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELR 2768



 Score =  402 bits (1034), Expect = e-111
 Identities = 316/987 (32%), Positives = 467/987 (47%), Gaps = 71/987 (7%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + +P F  P     +P N   GTP+ +LRA+DPD G   R+ +T+ A         F++D
Sbjct: 889  DNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA----GGGGAFTVD 944

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD--TNDHDPVFEQQE 293
            P TG V     L       H   + A+D G P R++   L ++V D  T    P F    
Sbjct: 945  PTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPT 1004

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
            Y+  L      G +VL V+A    AP    I Y L      SP   F ++P+SG +  R 
Sbjct: 1005 YRVDLPSGTTAGTQVLQVQA---QAPDGGPITYHLAAEGASSP---FGLEPQSGWLWVRA 1058

Query: 354  PVDREEVESYQLTVEA-SDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
             +DRE  E Y L V A S    + G ++ TA V +S+ + N+++P+ SE    + V E+ 
Sbjct: 1059 ALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQ 1118

Query: 413  TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQ-FYLDAQTGALDVVSPLDYETTKEYT 471
             PG  V RV A+DRD G N  + YS+   +   + F +  QTG +  +  LD E    Y 
Sbjct: 1119 PPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQ 1178

Query: 472  LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA------TVLESVPLGYLVL 525
            L V+ QDGG PP S  +G V V VLD+NDN+P F+     A       V + VP G LV 
Sbjct: 1179 LLVQVQDGGSPPRST-TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVT 1237

Query: 526  HVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
             +QA D D G+N  + Y L G G +  F+++  +G +  AA L R E   Y   + A D 
Sbjct: 1238 TLQAKDPDEGENGTILYTLTGPGSEL-FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296

Query: 586  GTPALTASASVSVTVL----------DVNDNNPTFTQPEY-TVRLNEDAAVGTSVVTVSA 634
            G+P  +AS  + V VL          D+ + +P    P   TV   E    G+ + +V+A
Sbjct: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA 1356

Query: 635  VDRDAHSVITYQITSG-NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ 693
             +      +TY +  G +    F++ + SG   + LA PLD++    +      ++G   
Sbjct: 1357 PEPAGVGALTYTLVGGADPEGTFALDAASGR--LYLARPLDFEAGPPWRALTVRAEGPGG 1414

Query: 694  DTAQIV---VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITY 749
              A+++   V V D N H P F      + + E+   G  +    A+D D  G N+ + Y
Sbjct: 1415 AGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRY 1474

Query: 750  FM---EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYLEI 803
             +   E  +P  R+DA TGA++    LD E   +  L + A D   N   +++      +
Sbjct: 1475 RLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARV 1534

Query: 804  LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD 863
             V D NDNAP F   S +  + ED PP  + L + A D D G   RV Y    G  GDG 
Sbjct: 1535 FVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG--GDGH 1591

Query: 864  FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
            F + S++G +  +R LDRE  A++VL   A D G PP      +TV+V DVND  P F+Q
Sbjct: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651

Query: 924  DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVD 983
             E+ V + EN+P G ++  + ATDPD G N Q+ Y    G   E F LD  +G LT L  
Sbjct: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA 1708

Query: 984  LDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSS 1040
            LD E++ E  L + A    S P ++  TV V + D ND+ P  G+  +         S  
Sbjct: 1709 LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL---------SLE 1759

Query: 1041 FPGG----AIGRVPAHDPDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALDNN-RP 1093
             P G     +  + A DPD+  +  L Y    G+     +L+ ++GE    R LD    P
Sbjct: 1760 VPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEP 1819

Query: 1094 LEAIMSVLVSDGVHSVTAQCALRVTII 1120
               +       G  +++A   L VT++
Sbjct: 1820 AFQLRIEARDGGQPALSATLLLTVTVL 1846



 Score =  378 bits (971), Expect = e-104
 Identities = 315/938 (33%), Positives = 438/938 (46%), Gaps = 55/938 (5%)

Query: 182  QPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV 241
            Q  S    + E QPAGT +  + A  P  G A  L Y + A   S      ++D  +G V
Sbjct: 43   QAGSLDLQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV 101

Query: 242  TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
             TA  LDRE +  + F     D       A   +T+ V D NDH P F Q      + E+
Sbjct: 102  RTARVLDREQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEH 155

Query: 302  LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT-------RGP 354
               G       A D DA       Y L   SG    E F ++ R G   T        G 
Sbjct: 156  TAFGTRYPLEPARDADAGRLGTQGYAL---SGDGAGETFRLETRPGPDGTPVPELVVTGE 212

Query: 355  VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
            +DRE    Y L +EA D G    PR   A + +++ D ND+AP F++ RY   V E + P
Sbjct: 213  LDRENRSHYMLQLEAYDGGSP--PRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270

Query: 415  GAPVLRVTASDRDKGSNAVVHYSI--MSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
            G+PVL+V ASD D G N  V Y I        G F +DA TG L +  PLD+E  + + L
Sbjct: 271  GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330

Query: 473  RVRAQDGGRPPLSNVSGLVTVQVLDINDNAP----IFVSTPFQATVLESVPLGYLVLHVQ 528
             V+A+DGG  P    S  VTV V D NDN P    IF+S      V E+ P G LV  + 
Sbjct: 331  VVQARDGGAHPELG-SAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARIS 389

Query: 529  AIDADAGDNARLEYRL-AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGT 587
              D D GD A +   L  G GH    T ++    + VA  LDREE D Y+  V A D G+
Sbjct: 390  VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449

Query: 588  PALTASASVSVTVLDVNDNNPTFTQPEYTVR-LNEDAAVGTSVVTVSAVDRD--AHSVIT 644
            P L A A+  + V DVNDN P F +  Y    L E A  G+ VV V+A D D   +  +T
Sbjct: 450  PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVN 701
            Y +  G   + FSI   S  G+++ A  LDY+LE Q  L V A+DG       +A + V 
Sbjct: 510  YSLAPGAHTHWFSIDPTS--GIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVA 567

Query: 702  VTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIP 756
            + D N + P FQ + Y  ++ E    GT  + ++ATD D+G    ++Y +         P
Sbjct: 568  LQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSP 627

Query: 757  QFRIDADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
             FRIDA +G V T   LD +    S+   +TA D G        Y+++ ++D NDN PQF
Sbjct: 628  PFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQF 685

Query: 816  LRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
                Y  S+    PP T+VL++ A D D G +GR+ Y    G +    F ++  SG++  
Sbjct: 686  YPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGLLTV 744

Query: 876  LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
               L R   +   L   A D G   A     V ++++     PP+FEQ ++   V E+  
Sbjct: 745  AWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVA 804

Query: 936  IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYE-DRPEYVL 994
             G +V  V A +P  G  A +   +  G+   +F LD  SG L  L  LD E   P   L
Sbjct: 805  PGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLEL 863

Query: 995  VIQATSA--PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
             ++A S   P  + A V V L D NDN P     E    + V    ++ PG  I  + A 
Sbjct: 864  EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYTLRAL 919

Query: 1053 DPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
            DPD  ++  +T++   G       ++ +TG ++L R L
Sbjct: 920  DPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPL 956



 Score =  370 bits (950), Expect = e-101
 Identities = 311/946 (32%), Positives = 450/946 (47%), Gaps = 49/946 (5%)

Query: 176  NTAPQFQPPSYQAT-VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
            + AP F    Y+   +PE    G+ V  + A DPD+G  G++ Y+   L       +FS+
Sbjct: 467  DNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS---LAPGAHTHWFSI 523

Query: 235  DPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            DP +G +TTA  LD E +      V A D G+P  ++ AT+++ + D ND++P F++  Y
Sbjct: 524  DPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFY 583

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
              SL E  + G   L V ATD D+ P   + Y L  G G S S  F ID  SG + T   
Sbjct: 584  NASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT 643

Query: 355  VDREE-VESYQLTVEASDQGRDPGPRSTT-AAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
            +DR++   S+  TV A D G   G +S     VFLS  D+NDN PQF  + Y   +    
Sbjct: 644  LDRDQGPSSFDFTVTAVDGG---GLKSMVYVKVFLS--DENDNPPQFYPREYAASISAQS 698

Query: 413  TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
             PG  VLR+ A D D+GS+  + Y I++GN+   F LD Q+G L V  PL         L
Sbjct: 699  PPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQL 758

Query: 473  RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
             + A+DGG    +  S  V + ++      PIF    +  +V E V  G  V  VQA + 
Sbjct: 759  EIGAEDGGGLQ-AEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN- 816

Query: 533  DAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
              G  A +   L+G      F+++  +G +     LDRE +            G P   A
Sbjct: 817  PPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFA 876

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG 650
             A V V + DVNDN+P F  PE TV L  + A GT + T+ A+D D+  +S +T+ + +G
Sbjct: 877  VARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG 936

Query: 651  NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANT 707
                  + T     G V L  PL       + L + A DG    R    ++ V V D  T
Sbjct: 937  GGG---AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGT 993

Query: 708  H--RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDAD 763
                P F S  Y V++     AGT V+ + A   D G    ITY +  E +   F ++  
Sbjct: 994  RGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQ 1050

Query: 764  TGAVTTQAELDYEDQVSYTL---AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
            +G +  +A LD E Q  Y L   A++     + Q++ T  + + + + N+++P+   D  
Sbjct: 1051 SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPT 1110

Query: 821  QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLD 880
              +V E+ PP TSV ++ ATDRDSG NGR+ Y+ Q   +    F +   +G V TL+ LD
Sbjct: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170

Query: 881  RENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDE------FDVFVEENS 934
            RE  + Y L     D G PP  T   V V VLD+NDN P F Q          + V +  
Sbjct: 1171 REQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRV 1230

Query: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
            P G  V  + A DPDEG N  I+Y +  G   E+F L   SGEL     L   +RP YVL
Sbjct: 1231 PPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289

Query: 995  VIQA---TSAPLVSRATVHVRLLDR---NDNPPVLGNFE----ILFNNYVTNRSSSFPGG 1044
             + A    S P  +   + V++L      + PP L   +    +     VT      PG 
Sbjct: 1290 TLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGS 1349

Query: 1045 AIGRVPAHDPDISDSLTYSFERG-NELSLVLLNASTGELKLSRALD 1089
             +G V A +P    +LTY+   G +      L+A++G L L+R LD
Sbjct: 1350 LLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395



 Score =  355 bits (912), Expect = 3e-97
 Identities = 306/979 (31%), Positives = 450/979 (45%), Gaps = 56/979 (5%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            AP F        +PEN   G  + + RA D D G     +     L          LD  
Sbjct: 1433 APAFARDPLALALPENPEPGAALYTFRASDAD-GPGPNSDVRYRLLRQEPPVPALRLDAR 1491

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            TGA++    LDRET    +  V A D   +   RR+A  +  + VTD ND+ PVF     
Sbjct: 1492 TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS- 1550

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
            +  L E+   G   L V A D D    A + YRL  G  G     F +   +G +    P
Sbjct: 1551 RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH----FRLHSSTGALSVVRP 1606

Query: 355  VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
            +DRE+   + LTV ASD G  P  RS T  + +SV D ND AP F ++ Y V +RE+  P
Sbjct: 1607 LDREQRAEHVLTVVASDHGSPP--RSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPP 1664

Query: 415  GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
            G  +L + A+D D G+N  V Y  +S  +   F LD  TG L  +  LD E  +E  L V
Sbjct: 1665 GTSLLTLRATDPDVGANGQVTYGGVSSES---FSLDPDTGVLTTLRALDREEQEEINLTV 1721

Query: 475  RAQDGGRPP-LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
             AQD G PP L++V+  V V V D ND+AP F S      V E      L + ++A D D
Sbjct: 1722 YAQDRGSPPQLTHVT--VRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPD 1778

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
             G N +L+YR+        F ++  +G       LDRE    +   +EARD G PAL+A+
Sbjct: 1779 VGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSAT 1838

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
              ++VTVLD ND+ P F  P Y+V + ED   GT ++ + A D D  A+  +TY + +G 
Sbjct: 1839 LLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG- 1897

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT 707
            T   F +   SG   +  A  LD +    Y  +V+A DG        T  + + V D N 
Sbjct: 1898 TAGAFLLEPSSGE--LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVND 1955

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISAT----DEDTGENARITYFMEDSIPQ-FRIDA 762
            H P F +S   + +    P+ +T  L  AT    D D G NA I Y +  + P    +D+
Sbjct: 1956 HAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDS 2015

Query: 763  DTGAV---TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS 819
             TG +    +   L   D+V   L I A D G P +S T  + + +    +  P+F R S
Sbjct: 2016 YTGEIRVARSPVALGPRDRV---LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRAS 2072

Query: 820  YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG--IVRTLR 877
             + ++ E+ PP T ++   A     G NG + Y+   G++  G F ++ ++G   VR+  
Sbjct: 2073 SEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNE-KGTFSIQPSTGAITVRSAE 2130

Query: 878  RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
             LD E V+  +      + G   A T +  T+T+ D NDN P F +  +  F+ E+ P+ 
Sbjct: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVL--TLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187

Query: 938  LAVARVTATDPDEGTNAQIMYQIVEGNIPE-VFQLDIFSGELTALVDLDYEDRPEYVLVI 996
              + +V A D D+G+  QI Y +        +F +D  +G +T    LD E   E  LV+
Sbjct: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247

Query: 997  QAT---SAPLVSRATVHVRLLDRNDNPPVLGN-FEILFNNYVTNRSSSFPGGAIGRVPAH 1052
             AT   S  LV  AT+ V ++D NDN P +   +E+  +        +  G  I +V  +
Sbjct: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVS------EDALLGSEIAQVTGN 2301

Query: 1053 DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQ 1112
            D D    L Y            +    G + L+  LD  +     + +L  DG H   A 
Sbjct: 2302 DVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN 2361

Query: 1113 CALRVTIITDEMLTHSITL 1131
              + V  + D     S +L
Sbjct: 2362 LTVLVEDVNDNAPAFSQSL 2380



 Score =  342 bits (878), Expect = 2e-93
 Identities = 300/984 (30%), Positives = 440/984 (44%), Gaps = 69/984 (7%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            AP F        VPE Q   T +  LRA DPD G  G+L+Y    + D   +  F LD  
Sbjct: 1748 APTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYR---ILDGDPSGAFVLDLA 1803

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
            +G   T   LDRE +     R+ A+D G P  SA   LT+ V D NDH P F    Y   
Sbjct: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVE 1863

Query: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
            + E++  G  +L ++A D DA  N ++ Y L  G+ G+    F ++P SG +RT   +DR
Sbjct: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA----FLLEPSSGELRTAAALDR 1919

Query: 358  EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED----VT 413
            E+  SY  +V A D G   GP STT +V ++V D ND+AP F      +++        T
Sbjct: 1920 EQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFST 1978

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
            P   +  + A DRD G+NA + Y + +G       +D+ TG + V         ++  L 
Sbjct: 1979 PTLALATLRAEDRDAGANASILYRL-AGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
            + A D GRP  S  +G++ V +    +  P F     +AT+ E+ P G  ++  +A+ A 
Sbjct: 2038 IVATDLGRPARS-ATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA- 2095

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISV--AAELDREEVDFYSFGVEARDHGTPALT 591
             G N  + Y +        F+I   TG I+V  A  LD E        ++A   G  A T
Sbjct: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155

Query: 592  ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITS 649
                +++T+ D NDN P F +P Y   L E   +   ++ V A D D  S   I+Y + +
Sbjct: 2156 V---LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA 2212

Query: 650  GN-TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANT 707
                R  F +   +G    +  L  +   E + VL  T         +A + V V D N 
Sbjct: 2213 SQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTG 765
            +RP      + + V+ED   G+ +  ++  D D+G    + Y +  S PQ  F +    G
Sbjct: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPV--LWYVLSPSGPQDPFSVGRYGG 2329

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
             V+    LD+E    Y L + A D     +++ T   +LV DVNDNAP F +  YQ  + 
Sbjct: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLT---VLVEDVNDNAPAFSQSLYQVMLL 2386

Query: 826  EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL-----D 880
            E  PP +++L +SATDRDSG NG + Y      DG   F V+  +G + T+        D
Sbjct: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADG---FSVDPNNGTLFTIVGTVALGHD 2443

Query: 881  RENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940
                   VL A   D G P       V V + D ND+ P F    + V V E+ P G  +
Sbjct: 2444 GSGAVDVVLEAR--DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTL 2501

Query: 941  ARVTATDPDEG-TNAQIMYQIVEGNIPEVFQLDIFSGE--------------LTALVDLD 985
              + ATD D   ++A + Y I+ GN   VFQL+    E              L  L  LD
Sbjct: 2502 LTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLD 2561

Query: 986  YEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP 1042
            +E   +Y L + A      P  S   V V +LD NDNPPV           VT    +  
Sbjct: 2562 FESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR----VTVPEDTPV 2617

Query: 1043 GGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
            G  +  V A D D      + ++   G+   L  L+ S+G L+L+ ALD        + V
Sbjct: 2618 GAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVV 2677

Query: 1101 LVSD--GVHSVTAQCALRVTIITD 1122
              +D  G H   A   + V  + D
Sbjct: 2678 QAADPAGAHFALAPVTIEVQDVND 2701



 Score =  342 bits (877), Expect = 3e-93
 Identities = 307/976 (31%), Positives = 436/976 (44%), Gaps = 52/976 (5%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD-- 235
            AP F        VPE+   GT      A D D G  G   Y   AL    + + F L+  
Sbjct: 140  APAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY---ALSGDGAGETFRLETR 196

Query: 236  ------PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVF 289
                  PV   V T E LDRE +S ++ ++ A D G P R A A L + + D NDH P F
Sbjct: 197  PGPDGTPVPELVVTGE-LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF 255

Query: 290  EQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRL--LEGSGGSPSEVFEIDPRSG 347
             Q  Y   + E+L  G  VL V A+D DA  N  + Y +   +  G  P   F ID  +G
Sbjct: 256  NQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP---FSIDAHTG 312

Query: 348  VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ----FSEKR 403
            +++   P+D E+   ++L V+A D G    P   +A V + V D NDN P     F    
Sbjct: 313  LLQLERPLDFEQRRVHELVVQARDGGAH--PELGSAFVTVHVRDANDNQPSMTVIFLSAD 370

Query: 404  YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVV---S 460
               QV E   PG  V R++ SD D G  A V+ S+  G   G F L  Q   + +V    
Sbjct: 371  GSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVAR 428

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
             LD E    Y LRV A D G PPL   +  V + V D+NDNAP F    ++   L  V L
Sbjct: 429  RLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVAL 487

Query: 521  -GYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
             G  V+ V A D D G N ++ Y LA   H   F+I+  +G I+ AA LD E        
Sbjct: 488  PGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLI 547

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D G P L +SA+VSV + DVNDN P F +  Y   L E    GT  + V+A D D+
Sbjct: 548  VVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADS 607

Query: 640  --HSVITYQITSG---NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQ 693
                +++Y + +G   +    F I + SG    +  L  D +    +   VTA D G  +
Sbjct: 608  GPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD-QGPSSFDFTVTAVDGGGLK 666

Query: 694  DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-- 751
                + V ++D N + P F    Y  +++   P GT V+ + A D D G + R++Y +  
Sbjct: 667  SMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILA 726

Query: 752  EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDN 811
             +S P F +D  +G +T    L         L I A D G  Q   +  ++I +      
Sbjct: 727  GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 786

Query: 812  APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG 871
             P F +  Y  SV EDV P TSV  + A     G    V  +  GGD   G F +++ SG
Sbjct: 787  PPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDP-RGLFSLDAVSG 844

Query: 872  IVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVE 931
            +++TLR LDRE +   +        G+PPA     V V + DVNDN P F   E  V + 
Sbjct: 845  LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904

Query: 932  ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPE 991
             N+  G  +  + A DPD G N+++ + ++ G     F +D  +G +  +  L     P 
Sbjct: 905  PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963

Query: 992  YVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNN---YVTNRSSSFPGGAIGR 1048
            + L ++A       R T H RL     +    G     FN+    V   S +  G  + +
Sbjct: 964  HELELEARDGGSPPR-TSHFRLRVVVQDVGTRG-LAPRFNSPTYRVDLPSGTTAGTQVLQ 1021

Query: 1049 VPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG--- 1105
            V A  PD    +TY        S   L   +G L +  ALD       I+ V+   G   
Sbjct: 1022 VQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080

Query: 1106 -VHSVTAQCALRVTII 1120
             +   T    +RV+I+
Sbjct: 1081 ELGQQTGTATVRVSIL 1096



 Score =  337 bits (864), Expect = 1e-91
 Identities = 285/908 (31%), Positives = 409/908 (45%), Gaps = 51/908 (5%)

Query: 322  ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRST 381
            A ++Y +    G        ID  SGV+RT   +DRE+ + Y+ T    D          
Sbjct: 74   APLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPD--------GA 125

Query: 382  TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSG 441
            T  V + V D ND+AP F + R  +QV E    G       A D D G      Y++   
Sbjct: 126  TVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGD 185

Query: 442  NARGQFYLDAQTG-------ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQ 494
             A   F L+ + G        L V   LD E    Y L++ A DGG PP      L+ V 
Sbjct: 186  GAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPP-RRAQALLDVT 244

Query: 495  VLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL--AGVGHDFP 552
            +LDIND+AP F  + + A V ES+  G  VL V A DADAG N  + Y +       D P
Sbjct: 245  LLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP 304

Query: 553  FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPT--- 609
            F+I+  TG + +   LD E+   +   V+ARD G      SA V+V V D NDN P+   
Sbjct: 305  FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTV 364

Query: 610  -FTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQ-SGGGLV 667
             F   + + +++E A  G  V  +S  D D        ++       F++++Q S   LV
Sbjct: 365  IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLV 424

Query: 668  SLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVN-VNE 723
             +A  LD +    Y L VTA+D      +  A  V++VTD N + P F    Y    + E
Sbjct: 425  CVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPE 484

Query: 724  DRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSY 781
                G+ VV ++A D D G N ++TY +        F ID  +G +TT A LDYE +   
Sbjct: 485  VALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP 544

Query: 782  TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
             L + A D G+P  + +  + + + DVNDN PQF R  Y  S+ E   P T  LQ++ATD
Sbjct: 545  QLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATD 604

Query: 842  RDSGLNGRVFYTFQG--GDDGDGDFIVESTSGIVRTLRRLDR-ENVAQYVLRAYAVDKGM 898
             DSG  G + Y+     G  G   F +++ SG V T R LDR +  + +     AVD G 
Sbjct: 605  ADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG- 663

Query: 899  PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMY 958
               ++ + V V + D NDNPP F   E+   +   SP G AV R+ A DPD+G++ ++ Y
Sbjct: 664  -GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSY 722

Query: 959  QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLD 1015
             I+ GN P +F LD  SG LT    L         L I A           A V + ++ 
Sbjct: 723  HILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVP 782

Query: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD-PDISDSLTYSFERGNELSLVL 1074
                PP+    + +F    +      PG ++G V AH+ P     +T S   G+   L  
Sbjct: 783  GTPTPPIFEQLQYVF----SVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFS 838

Query: 1075 LNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLE 1134
            L+A +G L+  R LD    L  ++ + V  G     A    RV ++ D++  +S      
Sbjct: 839  LDAVSGLLQTLRPLDREL-LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897

Query: 1135 DMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVG-----Q 1189
            +   +  L P        +    A  PD  V   V     A GG    V  + G     +
Sbjct: 898  E---DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMR 954

Query: 1190 PPGPGGGP 1197
            P GP GGP
Sbjct: 955  PLGPSGGP 962



 Score =  334 bits (856), Expect = 9e-91
 Identities = 263/832 (31%), Positives = 387/832 (46%), Gaps = 51/832 (6%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+F   S +AT+ EN P GTP+ S RA+    G  G + Y+   +        FS+ P T
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYS---ILSGNEKGTFSIQPST 2121

Query: 239  GAVT--TAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
            GA+T  +AE LD E        + A+  G     A   LT+ + D ND+ P F +  Y  
Sbjct: 2122 GAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVA 2178

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE-VFEIDPRSGVIRTRGPV 355
             L E+  +   +L V A D D      I Y L   +   P+  +F +DP +G I T   +
Sbjct: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSL---AASQPARGLFHVDPTTGTITTTAIL 2235

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            DRE     +L + A+D+G      S T  V   V D NDN P   +  + ++V ED   G
Sbjct: 2236 DREIWAETRLVLMATDRGSPALVGSATLTVM--VIDTNDNRPTIPQP-WELRVSEDALLG 2292

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
            + + +VT +D D G   V+ Y +     +  F +    G + +  PLD+E    Y L++ 
Sbjct: 2293 SEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350

Query: 476  AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
            A DG     +N+    TV V D+NDNAP F  + +Q  +LE  P G  +L V A D D+G
Sbjct: 2351 AHDGPHEGRANL----TVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406

Query: 536  DNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPALTASA 594
             N  + Y LA     F    NNGT +  V    L  +        +EARDHG P   A A
Sbjct: 2407 ANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARA 2466

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD---AHSVITYQITSGN 651
            +V V + D ND+ P+FT   Y V + ED   G++++T+ A D D   +H+ + Y I SGN
Sbjct: 2467 TVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526

Query: 652  TRNRFSI------TSQSGG------GLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIV 699
                F +        +S G      G + L  PLD++   QY L V A+D  +   + +V
Sbjct: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586

Query: 700  ---VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP 756
               V V D N + PVF  + Y V V ED P G  ++ + A+D D G +  + + +    P
Sbjct: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646

Query: 757  Q--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQ 814
               F +D  +G +     LD E Q  + L + A D      +    + I V DVND+ P 
Sbjct: 2647 SGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPA 2705

Query: 815  FLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG---GDDGDGDFIVESTSG 871
            F  +    SV E+ PP T V  + A D D+G  GR+ Y+      G +G   F + S++G
Sbjct: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765

Query: 872  IVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVE 931
             +R     D E+   + L   A D G   A   + V VT  D  D  PVF    F   V 
Sbjct: 2766 ELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQVP 2823

Query: 932  ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVD 983
            E +  G ++  V ATD D G +  ++Y +   +    F ++  +G L   VD
Sbjct: 2824 EGARRGHSLGHVQATDEDGGADGLVLYSLATSS--PYFGINQTTGALYLRVD 2873



 Score =  322 bits (826), Expect = 3e-87
 Identities = 292/949 (30%), Positives = 427/949 (44%), Gaps = 66/949 (6%)

Query: 173  RNVNT-APQFQPPSYQATVPENQPA-GTP---VASLRAIDPDEGEAGRLEYTMDALFDSR 227
            R+VN  AP F     +  +P   P+  TP   +A+LRA D D G    + Y +       
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010

Query: 228  SNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP 287
            +    ++D  TG +  A           V  + A D G P RSA   + + +    +  P
Sbjct: 2011 T----TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGP 2066

Query: 288  VFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
             F +   + ++REN   G  +++ RA       N  I Y +L G+       F I P +G
Sbjct: 2067 RFPRASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGN---EKGTFSIQPSTG 2122

Query: 348  VIRTRGP--VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405
             I  R    +D E     +L ++A     + G       + L+++D NDNAP+F    YV
Sbjct: 2123 AITVRSAEGLDFEVSPRLRLVLQA-----ESGGAFAFTVLTLTLQDANDNAPRFLRPHYV 2177

Query: 406  VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDY 464
              + E      P+L+V A D D+GS   + YS+ +   ARG F++D  TG +   + LD 
Sbjct: 2178 AFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDR 2237

Query: 465  ETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV 524
            E   E  L + A D G P L   S  +TV V+D NDN P  +  P++  V E   LG  +
Sbjct: 2238 EIWAETRLVLMATDRGSPALVG-SATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEI 2295

Query: 525  LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD 584
              V   D D+G    L Y L+  G   PF++    G +S+   LD E+ D Y   + A D
Sbjct: 2296 AQVTGNDVDSGPV--LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD 2353

Query: 585  HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSV 642
                     A+++V V DVNDN P F+Q  Y V L E    G+++++VSA DRD  A+  
Sbjct: 2354 GPHEG---RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410

Query: 643  ITYQITSGNTRNRFSITSQSGGGLV---SLALPLDYKLERQYVLAVTASDGT-RQDTAQI 698
            I+Y + S    + FS+   +G       ++AL  D       VL         R   A +
Sbjct: 2411 ISYHLAS--PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITYF------- 750
             V + D N H P F  SHY V V ED P G+T++ + ATD D +  +A + Y        
Sbjct: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG 2528

Query: 751  ----MEDSIPQFRIDADTG-----AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
                +E  + +    A  G      +     LD+E    Y L + A D G P +S    +
Sbjct: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV 2588

Query: 802  EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
             + V DVNDN P F R SY+ +V ED P    +L + A+D D G +G V +T   GD   
Sbjct: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS- 2647

Query: 862  GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK-GMPPARTPMEVTVTVLDVNDNPPV 920
            G F ++ +SG +R    LD E  A++ L   A D  G   A  P  VT+ V DVND+ P 
Sbjct: 2648 GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAP--VTIEVQDVNDHGPA 2705

Query: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE-GNIPE---VFQLDIFSG 976
            F  +     V EN P G  V  + A D D G   ++ Y ++E G  PE    F L+  +G
Sbjct: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765

Query: 977  ELTALVDLDYEDRPEYVLVIQATSA-PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVT 1035
            EL A V  DYE    + L++ A  A  L +  TV V +   ++  PV       F+  V 
Sbjct: 2766 ELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVF--LAPAFHFQVP 2823

Query: 1036 NRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKL 1084
              +    G ++G V A D D        +          +N +TG L L
Sbjct: 2824 EGARR--GHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870



 Score =  131 bits (330), Expect = 9e-30
 Identities = 144/493 (29%), Positives = 206/493 (41%), Gaps = 44/493 (8%)

Query: 713  QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSI-----PQFRIDADTGAV 767
            Q+    + ++E++PAGT +  ISA     G  A + YF+             ID  +G V
Sbjct: 43   QAGSLDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV 101

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
             T   LD E +  Y       D        T  + + V D+ND+AP F +      V E 
Sbjct: 102  RTARVLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEH 155

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD-FIVESTSGIVRT-------LRRL 879
                T      A D D+G  G   Y   G  DG G+ F +E+  G   T          L
Sbjct: 156  TAFGTRYPLEPARDADAGRLGTQGYALSG--DGAGETFRLETRPGPDGTPVPELVVTGEL 213

Query: 880  DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            DREN + Y+L+  A D G PP R    + VT+LD+ND+ P F Q  +   V E+   G  
Sbjct: 214  DRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSP 273

Query: 940  VARVTATDPDEGTNAQIMYQI----VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
            V +V A+D D G N  + Y+I     EG+ P  F +D  +G L     LD+E R  + LV
Sbjct: 274  VLQVFASDADAGVNGAVTYEINRRQSEGDGP--FSIDAHTGLLQLERPLDFEQRRVHELV 331

Query: 996  IQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
            +QA      P +  A V V + D NDN P +    +  +       ++ PG  + R+   
Sbjct: 332  VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391

Query: 1053 DPDISD--SLTYSFERG-NELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHS 1108
            DPD  D   +  S E G    +L   ++    + ++R LD        + V  +D G   
Sbjct: 392  DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451

Query: 1109 VTAQCA--LRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVV 1166
            + A+ A  L VT + D        L   +  PE     L G F+  V    A  PD    
Sbjct: 452  LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPE---VALPGSFVVRVT---ARDPDQGTN 505

Query: 1167 FNVQRDTDAPGGH 1179
              V     APG H
Sbjct: 506  GQVTYSL-APGAH 517


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  407 bits (1045), Expect = e-112
 Identities = 309/983 (31%), Positives = 466/983 (47%), Gaps = 44/983 (4%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+F  P Y  + PE+ P G+ +  ++A+   +     L        +S  +  FSLDP T
Sbjct: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSL--VRGTTPESNKDGVFSLDPDT 2746

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRS--ALATLTILVTDTNDHDPVFEQQEYKE 296
            G +   + +D E  ST ++++    H +      +L ++ I V D ND+ PVFE   YK 
Sbjct: 2747 GVIKVRKPMDHE--STKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKA 2804

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             L EN+ VG  V+ V A D D   +  + YRL    G +  E+F ID  SG I T   +D
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELD 2864

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
             E  ++Y   V A D G+     S+ A V +S+ D+NDNAP+F+ + Y   V E+  PG 
Sbjct: 2865 CETCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923

Query: 417  PVLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTG---ALDVVSPLDYETTKEYTL 472
             V  +   D D    N  V   I  G+  GQF + +Q G    +     LD E T +Y L
Sbjct: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982

Query: 473  RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
            RV A DG        S  V + VLD+NDN+P      +   V E V  G+ +L V A D 
Sbjct: 2983 RVTASDGK----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDL 3038

Query: 533  DAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
            D   NA++ Y L G G H+F   ++  TG ++    LDRE  D ++   +A D G    +
Sbjct: 3039 DTDTNAQITYSLHGPGAHEFK--LDPHTGELTTLTALDRERKDVFNLVAKATDGG--GRS 3094

Query: 592  ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITS 649
              A +++ V DVNDN P F      V + ++  V T V  V A D D  A++ + Y +  
Sbjct: 3095 CQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPD 3154

Query: 650  GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTR---QDTAQIVVNVTDA 705
             +    FSI + +G  ++ L  PL  + +    L V ASD GT         + V+V   
Sbjct: 3155 -SAEGHFSIDATTG--VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGL 3211

Query: 706  NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG 765
              + PVF ++ ++V V ED P GT V+ ++       E         +   +FR+DA TG
Sbjct: 3212 EDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTG 3271

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
             +   A LD+E    Y L+I          SD T + + + DVN++ PQF +D Y   V 
Sbjct: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVL 3331

Query: 826  EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVA 885
            E+      +L +SATD D  LN  + Y+  GG+   G F +    G ++  + LDRE  +
Sbjct: 3332 ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGELQVAKALDREQAS 3390

Query: 886  QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
             Y L+  A D G PP     ++ + V DVNDNPP F Q  +   V+ENSPIG  V ++  
Sbjct: 3391 SYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLIL 3450

Query: 946  TDPDEGTNA-QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA--- 1001
            +DPD   N     ++I +GN    F++    G L     L    +  Y L IQA+ +   
Sbjct: 3451 SDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDSGIP 3509

Query: 1002 PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLT 1061
            PL S  +V V + +++   P     EI    ++T     F GG +G++ A D D  D+LT
Sbjct: 3510 PLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVGKIHATDRDPQDTLT 3565

Query: 1062 YSFERGNELSL-VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTII 1120
            YS      L     + A  G++  ++ L          +V VSDG  + TA   + V  +
Sbjct: 3566 YSLAEEETLGRHFSVGAPDGKIIAAQGLPRG---HYSFNVTVSDGTFTTTAGVHVYVWHV 3622

Query: 1121 TDEMLTHSITLRLEDMSPERFLS 1143
              E L  ++ +    ++PE  +S
Sbjct: 3623 GQEALQQAMWMGFYQLTPEELVS 3645



 Score =  382 bits (982), Expect = e-105
 Identities = 287/952 (30%), Positives = 448/952 (47%), Gaps = 86/952 (9%)

Query: 180  QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
            +F+   Y+  + E  P G+ V  +R           L+Y +     S  N  F L+  TG
Sbjct: 361  KFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN----LQYVLKP---SSENVGFKLNARTG 413

Query: 240  AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
             +TT + +D   ++ +   +           A   + I + D N+H P+F +  Y  +L 
Sbjct: 414  LITTTKLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLD 468

Query: 300  ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
            EN+  G  VL V ATD D   N  + Y +     G  +  F IDP  G+I T  P+D E 
Sbjct: 469  ENIPPGTSVLAVTATDRDHGENGYVTYSI----AGPKALPFSIDPYLGIISTSKPMDYEL 524

Query: 360  VES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
            ++  Y   V ASD G  P  R    ++FL + + NDN P F E      +R+D   G  +
Sbjct: 525  MKRIYTFRVRASDWG-SPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSI 583

Query: 419  LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE---YTLRVR 475
            + ++A D D+  N  + Y I+SGN    F L+  +G + +  P    T  +   Y+L++ 
Sbjct: 584  MTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKIT 641

Query: 476  AQDGGR-------------------PPLSNVSGLVT------------------------ 492
            A DG                     P   + +G++T                        
Sbjct: 642  ASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTS 701

Query: 493  VQVLDINDNAPIFVS-TPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDF 551
            +    IN   P F    P    VLESVP+   +  + A D DAG N +L Y +A    + 
Sbjct: 702  LSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEG 761

Query: 552  PFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFT 611
             F I   TG ++VAA LD E  +FY   V   D GTP  ++   ++V V D NDN P F 
Sbjct: 762  CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFP 821

Query: 612  QPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLAL 671
               Y + ++ED  VGT++  ++  D D+      + T  +   +FS+   +G  +V+   
Sbjct: 822  PGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVT--G 879

Query: 672  PLDYKLERQYVLAVTASDGTRQ-----DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRP 726
             LD + E +Y+L V A D   +         +++ + D N + P   + H  + V ED P
Sbjct: 880  HLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP 939

Query: 727  AGTTVVLISATDEDTGENARITY-FMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAI 785
             GT +  + A+D D G    + Y  M+ +   FR+D  TGA+  + ELD+E +  Y L++
Sbjct: 940  PGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSL 999

Query: 786  TARDNGIPQKSDT-TYLEILVNDVNDN--APQFLRDSYQGSVYEDVPPFTSVLQISATDR 842
             A D G P    T  ++E++V DVN+N   P F    +QG V E+ P  T V+ ++A D 
Sbjct: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059

Query: 843  DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
            DSGL+G + Y  + G  G   F +   +G+++TL  LDRE  + Y L   AVD+G  P  
Sbjct: 1060 DSGLDGELQYFLRAG-TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118

Query: 903  TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
            +  EV + V D NDNPP   Q  F   ++E++P+G +V ++ A DPD  +  ++ + I  
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178

Query: 963  GNIPEVFQLDIFSGELTALVDLDYEDRPEYVL---VIQATSAPLVSRATVHVRLLDRNDN 1019
            GN    F +   +G L+    LD E++ E++L   V+      L S + V V +LD NDN
Sbjct: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238

Query: 1020 PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNE 1069
            PP+  +   LFN  +  R S    G + R+ A D D  ++  +TYS E  +E
Sbjct: 1239 PPIFSH--KLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDE 1288



 Score =  381 bits (979), Expect = e-105
 Identities = 304/1044 (29%), Positives = 485/1044 (46%), Gaps = 89/1044 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            N AP F   SY  T+ EN P GT V ++ A D D GE G + Y++           FS+D
Sbjct: 453  NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI----AGPKALPFSID 508

Query: 236  PVTGAVTTAEELDRE-TKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQE 293
            P  G ++T++ +D E  K  + FRV A D G P RR    ++ + + + ND+ P+FE+  
Sbjct: 509  PYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVN 568

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
               S+R++  VG  ++T+ A D D     N+ Y ++    G+  E F+++  SGVI  + 
Sbjct: 569  CTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHFSGVISLKR 623

Query: 354  P---VDREEVESYQLTVEASDQGRDPGPRSTTAAVF------------------------ 386
            P   +   +  SY L + ASD      P +    V                         
Sbjct: 624  PFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTI 683

Query: 387  ------------------LSVEDDNDNAPQFSEK-RYVVQVREDVTPGAPVLRVTASDRD 427
                              LS    N   PQF +     + V E V    P+ R+ A+D D
Sbjct: 684  LHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPD 743

Query: 428  KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNV 487
             G N  + Y I  GN  G F ++ +TG L V +PLDYE T  Y L V   D G P  S+ 
Sbjct: 744  AGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSW 803

Query: 488  SGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
              L+TV V D NDNAP F    +Q T+ E   +G  +  +   DAD+ DN R+ Y L  +
Sbjct: 804  K-LLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL--L 860

Query: 548  GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA--LTASASVSVTVLDVND 605
                 F+++  TG + V   LDRE    Y   VEARD  +    L +   + +T+ DVND
Sbjct: 861  SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVND 920

Query: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV--ITYQITSGNTRNRFSITSQSG 663
            N+P        +++ ED   GT +  + A D D      + Y +  G     F +   +G
Sbjct: 921  NSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTG 979

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDT------AQIVVNVTDANTHRPVFQSSHY 717
               + L   LD++    Y L++ ASDG R          +++V   + N H P F S  +
Sbjct: 980  A--LILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVH 1037

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDADTGAVTTQAELDY 775
               V E+ P+GT V++++A D+D+G +  + YF+     +  F I+ DTG + T A LD 
Sbjct: 1038 QGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDR 1097

Query: 776  EDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVL 835
            E    Y L + A D G    S  T + I V D NDN PQ  +  +  S+ ED P  TSVL
Sbjct: 1098 EFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL 1157

Query: 836  QISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVD 895
            Q+ A D DS   G++ +    G +  G F++   +G++ T ++LDREN  +++L    +D
Sbjct: 1158 QLDAWDPDSSSKGKLTFNITSG-NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD 1216

Query: 896  KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN-SPIGLA-VARVTATDPDEGTN 953
             G P  ++   V V +LDVNDNPP+F    F+V + E  SP+    V R+ A+D DEG N
Sbjct: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLN 1276

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVH 1010
             ++ Y I E +  E F +D+ +G +++     +      +L I+AT +   PL +   +H
Sbjct: 1277 GRVTYSI-EDSDEEAFSIDLVTGVVSS--SSTFTAGEYNILTIKATDSGQPPLSASVRLH 1333

Query: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD-PDISDSLTYSFERGNE 1069
            +  +       +   F+  + ++    +       +G +     P +     ++   G++
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGL---FWFNISGGDK 1389

Query: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSI 1129
                 +  +TG + ++R LD  R     ++V V+DG  ++  Q  + +    +      +
Sbjct: 1390 DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFL 1449

Query: 1130 TLRLEDMSPERFLSPLLGLFIQAV 1153
              R E   P+  +  +  L +QA+
Sbjct: 1450 ETRYEVRVPQDTVPGVELLRVQAI 1473



 Score =  371 bits (953), Expect = e-102
 Identities = 307/975 (31%), Positives = 470/975 (48%), Gaps = 53/975 (5%)

Query: 155  GLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQAT-VPENQPAGTPVASLRAIDPDEGEA 213
            GL+  E S EE       +  +  PQF+    Q+  V E+ P  TP+A L A DPD G  
Sbjct: 688  GLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFN 747

Query: 214  GRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALA 273
            G+L Y    + D      F ++  TG +T A  LD E  + ++  VT  D G P++S+  
Sbjct: 748  GKLVYV---IADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWK 804

Query: 274  TLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG 333
             LT+ V D ND+ P F    Y+ ++ E+ EVG  +  +   D D+  N  + Y LL    
Sbjct: 805  LLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL---- 860

Query: 334  GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDN 393
             SP+E F + P +G +   G +DRE    Y L VEA DQ        +   + +++ED N
Sbjct: 861  -SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVN 919

Query: 394  DNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT 453
            DN+PQ   +   ++V ED+ PG  +  + ASD D G    V Y +M G A G F +D  T
Sbjct: 920  DNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMT 978

Query: 454  GALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA--PIFVSTPFQ 511
            GAL +   LD+E    Y L + A DGGRP        V V VLD+N+N   P F S   Q
Sbjct: 979  GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038

Query: 512  ATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-AGVGHDFPFTINNGTGWISVAAELDR 570
              V E+ P G  V+ V A D D+G +  L+Y L AG G    F+IN  TG I   A LDR
Sbjct: 1039 GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLA-AFSINQDTGMIQTLAPLDR 1097

Query: 571  EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
            E   +Y   V A D G+  L++   V + V D NDN P  +Q  +   + EDA VGTSV+
Sbjct: 1098 EFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL 1157

Query: 631  TVSAVDRDAHS--VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
             + A D D+ S   +T+ ITSGN    F I   +  GL+S A  LD + + +++L VT  
Sbjct: 1158 QLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT--GLLSTAQQLDRENKDEHILEVTVL 1215

Query: 689  DG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNE--DRPAGTTVVLISATDEDTGE 743
            D    + + T+++VV + D N + P+F    + V + E     +   V  + A+D D G 
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGL 1275

Query: 744  NARITYFMEDSIPQ-FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTT--Y 800
            N R+TY +EDS  + F ID  TG V++ +     +     L I A D+G P  S +   +
Sbjct: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEY--NILTIKATDSGQPPLSASVRLH 1333

Query: 801  LEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDG 860
            +E +      + P    ++Y      +  P   ++ + + +   G  G  ++   GGD  
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---GRPGLFWFNISGGDK- 1389

Query: 861  DGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV 920
            D DF +E T+G +   R LD    + Y L     D G     T + + + + ++N + P 
Sbjct: 1390 DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQ 1447

Query: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIP---EVFQLDIFSGE 977
            F +  ++V V +++  G+ + RV A D D+G +  ++Y I     P    +FQLD  SG 
Sbjct: 1448 FLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGV 1505

Query: 978  LTALVDLDYEDRP-EYVLVIQATSAPLVSR-----ATVHVRLLDRNDNPPVLGNFEILFN 1031
            L  +  LD    P ++ L +      +  +      T+HV   D N +PP     ++ + 
Sbjct: 1506 LVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE--DGNLHPPRF--TQLHYE 1561

Query: 1032 NYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
              V +  +  PG  + +V A D D  ++  + YS  +GN      +NA  G + L++ LD
Sbjct: 1562 ASVPDTIA--PGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619

Query: 1090 NNRPLEAIMSVLVSD 1104
                    ++V   D
Sbjct: 1620 QANHAPHTLTVKAED 1634



 Score =  342 bits (877), Expect = 3e-93
 Identities = 302/1001 (30%), Positives = 469/1001 (46%), Gaps = 54/1001 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P+F+ P Y+A V E    G  V  ++AIDPD  +  RLEY    +     ++ F ++  +
Sbjct: 2377 PEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDRHFFINSSS 2433

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
            G ++      +   S++  RV A D G+ R  A   + I  T+ N + P F+Q  Y+  L
Sbjct: 2434 GIISMFNLCKKHLDSSYNLRVGASD-GVFR--ATVPVYINTTNANKYSPEFQQHLYEAEL 2490

Query: 299  RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
             EN  VG +V+ + A D D+ P   I Y ++       SE F I+P +G I T   +DRE
Sbjct: 2491 AENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLA---SEKFSINP-NGQIATLQKLDRE 2546

Query: 359  EVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
               S +  +      RD G R     V + + D+NDN PQF    Y V ++ +V+  +PV
Sbjct: 2547 N--STERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPV 2604

Query: 419  LRVTASDRDKGSNAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
            ++V A D D+G NA V YS+   +  +    ++  TG + V   L     +     ++AQ
Sbjct: 2605 IQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQ 2664

Query: 478  DGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA-DAGD 536
            DGG PP  N    V +QV+    + P F    +  +  E +P G  +  V+A+ A D   
Sbjct: 2665 DGG-PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI 2723

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
             + +         D  F+++  TG I V   +D E    Y   V A       + +  SV
Sbjct: 2724 YSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSV 2783

Query: 597  SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITS---GN 651
            ++ V DVNDN P F    Y   L E+  VGTSV+ V+A+D+D      ++Y++++    N
Sbjct: 2784 NIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSN 2843

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT 707
                F+I S+S  G ++    LD +  + Y   V A D  +       A + V++TD N 
Sbjct: 2844 VHELFAIDSES--GWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDEND 2901

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIP--QFRID--A 762
            + P F S  Y  +V E+   G  V  +   D D  E N ++T ++ +  P  QF I    
Sbjct: 2902 NAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG 2961

Query: 763  DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
            D   ++++  LD E    Y L +TA D G  Q S T  +EI V DVNDN+PQ  +  Y G
Sbjct: 2962 DEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVT--VEIFVLDVNDNSPQCSQLLYTG 3018

Query: 823  SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
             V+EDV P   +L++SATD D+  N ++ Y+  G   G  +F ++  +G + TL  LDRE
Sbjct: 3019 KVHEDVFPGHFILKVSATDLDTDTNAQITYSLHG--PGAHEFKLDPHTGELTTLTALDRE 3076

Query: 883  NVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR 942
                + L A A D G    +   ++T+ V DVNDN P F      V V +N+ +   VA 
Sbjct: 3077 RKDVFNLVAKATDGGGRSCQA--DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAV 3134

Query: 943  VTATDPDEGTNAQIMYQI---VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA- 998
            V A DPD+G NAQ++Y +    EG+    F +D  +G +     L    +    L ++A 
Sbjct: 3135 VFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRAS 3190

Query: 999  ---TSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD 1055
               T  PL +  TV V ++   D  PV  N E    + V     + PG  + ++      
Sbjct: 3191 DLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTE----HSVQVPEDAPPGTEVLQLATLTRP 3246

Query: 1056 ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCAL 1115
             ++   Y    GNE     L+A TG L ++ +LD     +  +S+  S    S  +    
Sbjct: 3247 GAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTT 3306

Query: 1116 RVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAAT 1156
             +  ITD +  H      +  S     + L+G  I  V+AT
Sbjct: 3307 VMVNITD-VNEHRPQFPQDPYSTRVLENALVGDVILTVSAT 3346



 Score =  321 bits (822), Expect = 8e-87
 Identities = 275/966 (28%), Positives = 443/966 (45%), Gaps = 62/966 (6%)

Query: 177  TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
            +AP F    Y   +PE+ P G+P+  + A+ P E      E   D +F        S++ 
Sbjct: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVF--------SMNS 1707

Query: 237  VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
             +G ++T ++LD E  S++  ++   +        +  + I+  D ND+ P+F +  +  
Sbjct: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVG 1765

Query: 297  SLREN-------LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349
             + E        ++       + A+D D   N+ ++Y++LE       + F+IDP  G +
Sbjct: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEA---LKFFKIDPSMGTL 1822

Query: 350  RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
                 +D E + S+Q  V   DQG         A V + V D ND+ P+FSE+ Y V + 
Sbjct: 1823 TIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIV 1882

Query: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
              + PG  +L V ASD D    + V+YSI +GNA     +   TG++ V++P     +++
Sbjct: 1883 GPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK 1938

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
             T  +RA DG    L   + LV + +  + D +  F    + A V E++     ++ + A
Sbjct: 1939 LT--IRASDG----LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA 1992

Query: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
                  D   L Y L   G D    + +     +     DRE+ D +   VE RD+ TP 
Sbjct: 1993 QGNHLNDT--LSYFLLN-GTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049

Query: 590  LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQI 647
              A   V V++ DVNDN P F    Y   + +    G  +  VSA D D   +  +TY+ 
Sbjct: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109

Query: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG-TRQDTAQIVVNVTDAN 706
                T   F I    G   +SL  P DY+   +Y L V A DG T    ++  V VT  N
Sbjct: 2110 AEDYTY--FRIDPYLGD--ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRN 2165

Query: 707  THRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDADT 764
               P+FQS +Y V V E+    T ++    T   + E  R+ Y +  E+ +  F  D  T
Sbjct: 2166 KSNPLFQSPYYKVRVPENITLYTPIL---HTQARSPEGLRLIYNIVEEEPLMLFTTDFKT 2222

Query: 765  GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
            G +T    LDYE +  +   + A D  +   S+ T +E+LV DVNDN P F +  Y  S+
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSI 2281

Query: 825  YEDVPPFTSVLQISATDRDSGLNGRVFYTF-QGGDDGDGDFIVESTSGIVRTLRRLDREN 883
             E +P  T V+Q+ A+D+DSG N  V Y   + G D    F +  ++G + T++ LD E 
Sbjct: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341

Query: 884  VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
               + ++  A+DKG PP      V V V D+NDNPP F Q +++  V E +  G  V +V
Sbjct: 2342 QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV 2401

Query: 944  TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPL 1003
             A DPD    +++ Y I+ GN    F ++  SG ++            Y L + A+    
Sbjct: 2402 QAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG-- 2459

Query: 1004 VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTN---RSSSFPGGAIGRVPAHDPDISDSL 1060
            V RATV V +   N N      +   F  ++       ++  G  +  + A D D     
Sbjct: 2460 VFRATVPVYINTTNAN-----KYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYG 2514

Query: 1061 TYSFERGNELSLVLLNAS-TGELKLSRALDNNRPLEAIMS--VLVSDGVHSVTAQCALRV 1117
            T  +   N+L+    + +  G++   + LD     E +++  V+  DG   V A C +++
Sbjct: 2515 TIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRV-AFCTVKI 2573

Query: 1118 TIITDE 1123
             I+TDE
Sbjct: 2574 -ILTDE 2578



 Score =  306 bits (784), Expect = 2e-82
 Identities = 277/1016 (27%), Positives = 445/1016 (43%), Gaps = 140/1016 (13%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F PPSY+ T+ E+ P  +P+  + A D D G+     Y     F++RS + F++ P +
Sbjct: 146  PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA----FNTRS-EMFAIHPTS 200

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDH----------------------GMPRRSALATLT 276
            G VT A +L+   +  H  +V A D                        + +  A+A++ 
Sbjct: 201  GVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV 260

Query: 277  ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
            +   D+ND         Y   L +    G EV +V    GD   +   +      +  S 
Sbjct: 261  VTPPDSND------GTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSL 314

Query: 337  SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
              V +I+              E +  + L+++A       GP   +      +     ++
Sbjct: 315  VSVKDIN------------WMEYLHGFNLSLQARS---GSGPYFYSQIRGFHLPPSKLSS 359

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
             +F +  Y VQ+ E   PG+ V+ V  +         + Y +   +    F L+A+TG +
Sbjct: 360  LKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN----LQYVLKPSSENVGFKLNARTGLI 415

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE 516
                 +D+     Y L +R   G        S +V + ++D N++AP+F  + +  T+ E
Sbjct: 416  TTTKLMDFHDRAHYQLHIRTSPG------QASTVVVIDIVDCNNHAPLFNRSSYDGTLDE 469

Query: 517  SVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD-F 575
            ++P G  VL V A D D G+N  + Y +AG     PF+I+   G IS +  +D E +   
Sbjct: 470  NIPPGTSVLAVTATDRDHGENGYVTYSIAG-PKALPFSIDPYLGIISTSKPMDYELMKRI 528

Query: 576  YSFGVEARDHGTP-ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA 634
            Y+F V A D G+P       S+ + + ++NDN P F +   T  + +D  VG S++T+SA
Sbjct: 529  YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588

Query: 635  VDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALP---LDYKLERQYVLAVTASDGT 691
            +D D    + Y+I SGN    F +   S  G++SL  P   L       Y L +TASDG 
Sbjct: 589  IDVDELQNLKYEIVSGNELEYFDLNHFS--GVISLKRPFINLTAGQPTSYSLKITASDGK 646

Query: 692  R--QDTAQIVVNVTDANTHRPV------------------------------------FQ 713
                 T   +  V D +   PV                                    +Q
Sbjct: 647  NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706

Query: 714  SSHYT----------VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRID 761
             +HYT          ++V E  P  T +  ++ATD D G N ++ Y + D   +  F I+
Sbjct: 707  INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
             +TG +T  A LDYE    Y L +T  D G PQKS    L + V D NDNAP+F    YQ
Sbjct: 767  LETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQ 826

Query: 822  GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
             ++ ED    T++ +++  D DS  NGRV YT     +    F +   +G +     LDR
Sbjct: 827  LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLDR 883

Query: 882  ENVAQYVLRAYAVDKGMPPAR-----TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
            E+  +Y+L+  A D+   P++     +  ++ +T+ DVNDN P    +   + V E+ P 
Sbjct: 884  ESEPRYILKVEARDQ---PSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940

Query: 937  GLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVI 996
            G  +  + A+DPD G   ++ Y +++G     F++D+ +G L    +LD+E R  Y L +
Sbjct: 941  GTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSL 999

Query: 997  QATSA--PLVSRATVHVR--LLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVP 1050
             A+    PL  R   HV   +LD N+N  PP   +F  +    V   S S  G  +  V 
Sbjct: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF--VHQGQVQENSPS--GTQVIVVA 1055

Query: 1051 AHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            A D D  +   L Y    G  L+   +N  TG ++    LD        ++VL  D
Sbjct: 1056 AQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111



 Score =  287 bits (735), Expect = 9e-77
 Identities = 224/679 (32%), Positives = 324/679 (47%), Gaps = 31/679 (4%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + AP+F    Y+ +V EN   G  VA+L+ +D D  E  R         D       S  
Sbjct: 2901 DNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV 2960

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
                 +++ + LDRE  + ++ RVTA D    +  A  T+ I V D ND+ P   Q  Y 
Sbjct: 2961 GDEWRISSRKTLDREHTAKYLLRVTASD---GKFQASVTVEIFVLDVNDNSPQCSQLLYT 3017

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
              + E++  G+ +L V ATD D   NA I Y L     G  +  F++DP +G + T   +
Sbjct: 3018 GKVHEDVFPGHFILKVSATDLDTDTNAQITYSL----HGPGAHEFKLDPHTGELTTLTAL 3073

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            DRE  + + L  +A+    D G RS  A + L VED NDNAP+F      V V ++ T  
Sbjct: 3074 DRERKDVFNLVAKAT----DGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVK 3129

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
             PV  V A D D+G+NA V YS +  +A G F +DA TG + +  PL         L VR
Sbjct: 3130 TPVAVVFARDPDQGANAQVVYS-LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188

Query: 476  AQDGGRP-PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            A D G P PLS + G VTV V+ + D  P+F++T     V E  P G  VL +  +    
Sbjct: 3189 ASDLGTPIPLSTL-GTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPG 3247

Query: 535  GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
             +  +  YR+        F ++  TG + V A LD E    Y   +E     + +L+   
Sbjct: 3248 AE--KTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVT 3305

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNT 652
            +V V + DVN++ P F Q  Y+ R+ E+A VG  ++TVSA D D   +S ITY +  GN 
Sbjct: 3306 TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ 3365

Query: 653  RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHR 709
               F+I  + G   + +A  LD +    Y L + A+D  +    +   I + V D N + 
Sbjct: 3366 LGHFTIHPKKGE--LQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423

Query: 710  PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA-----RITYFMEDSIPQFRIDADT 764
            P F   +Y+  V E+ P G+ V+ +  +D D+ EN      RIT     S   FR+  D 
Sbjct: 3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGS--AFRVTPDG 3481

Query: 765  GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
              VT +  L    Q  Y L I A D+GIP  S  T + + V + +  AP  L      +V
Sbjct: 3482 WLVTAEG-LSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITV 3540

Query: 825  YEDVPPFTSVLQISATDRD 843
             ED      V +I ATDRD
Sbjct: 3541 GEDEFQGGMVGKIHATDRD 3559



 Score =  260 bits (665), Expect = 1e-68
 Identities = 247/985 (25%), Positives = 432/985 (43%), Gaps = 65/985 (6%)

Query: 154  PGLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEA 213
            P L A  R   E +   R  ++  A  F    Y  TV E  P    V  +      EG  
Sbjct: 1324 PPLSASVRLHIEWIPWPRPSSIPLA--FDETYYSFTVMETDPVNHMVGVISV----EGRP 1377

Query: 214  GRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALA 273
            G   + +        +  F ++  TG++  A  LD   +S +   V   D    R  A  
Sbjct: 1378 GLFWFNISG---GDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS--RTIATQ 1432

Query: 274  TLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG 333
                ++ + N H P F +  Y+  + ++   G E+L V+A D D     +++Y +     
Sbjct: 1433 VHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDK--GKSLIYTIHGSQD 1490

Query: 334  GSPSEVFEIDPRSGVIRTRGPVDREEVES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDD 392
               + +F++DP SGV+ T G +D     S + LTV   DQ  +   +     V + VED 
Sbjct: 1491 PGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ--EIPIKRNFVWVTIHVEDG 1548

Query: 393  NDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQ 452
            N + P+F++  Y   V + + PG  +L+V A D D+G NA VHYS++ GN+ G F ++A 
Sbjct: 1549 NLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINAL 1608

Query: 453  TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
             G + +   LD      +TL V+A+D G P   +++  V + V   + +APIF  + +  
Sbjct: 1609 LGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLA-TVIIHVYPSDRSAPIFSKSEYFV 1667

Query: 513  TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREE 572
             + ES+P+G  +L V A+       + + Y L     D  F++N+ +G IS   +LD E+
Sbjct: 1668 EIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEK 1722

Query: 573  VDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV------- 625
            +   S+ ++ R            V V ++D NDN P F +  +  +++E A +       
Sbjct: 1723 IS--SYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDK 1780

Query: 626  --GTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVL 683
                 V+  S  D++A+S++ Y+I        F I      G +++   +DY+    +  
Sbjct: 1781 NNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQF 1838

Query: 684  AVTASDG-----TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
             V   D           AQ++++V D N   P F    Y V +      G  ++++ A+D
Sbjct: 1839 CVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASD 1898

Query: 739  EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
            ED+  N  I     D          + +V   A L     +S  L I A D G+ Q  DT
Sbjct: 1899 EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG----LSRKLTIRASD-GLYQ--DT 1951

Query: 799  TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD 858
              ++I +  V D + QF +D Y  +V E++    +++ + A  + + LN  + Y    G 
Sbjct: 1952 ALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNGT 2009

Query: 859  DGDGDFIVESTSGIVRTLR-RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
            D    F +  ++G+++T     DRE    + L     D   P       V V++ DVNDN
Sbjct: 2010 D---MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDN 2066

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            PP F+   +   +++ +  G  + +V+ATD D GTN  + Y+  E      F++D + G+
Sbjct: 2067 PPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY--TYFRIDPYLGD 2124

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLVS-RATVHVRLLDRNDNPPVLGN--FEILFNNYV 1034
            ++     DY+   +Y L + A      S ++   V +  RN + P+  +  +++     +
Sbjct: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENI 2184

Query: 1035 TNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPL 1094
            T  +       I    A  P+    L Y+      L L   +  TG L ++  LD     
Sbjct: 2185 TLYT------PILHTQARSPE-GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKT 2237

Query: 1095 EAIMSVLVSDGVHSVTAQCALRVTI 1119
            + + +V  +D      ++  + V +
Sbjct: 2238 KHVFTVRATDTALGSFSEATVEVLV 2262



 Score =  249 bits (636), Expect = 3e-65
 Identities = 189/599 (31%), Positives = 280/599 (46%), Gaps = 24/599 (4%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + +PQ     Y   V E+   G  +  + A D D     ++ Y++           F LD
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHG----PGAHEFKLD 3061

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
            P TG +TT   LDRE K   VF + A+      RS  A +T+ V D ND+ P F      
Sbjct: 3062 PHTGELTTLTALDRERKD--VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCA 3119

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
             ++ +N  V   V  V A D D   NA ++Y L + + G     F ID  +GVIR   P+
Sbjct: 3120 VAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPL 3175

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
                    +LTV ASD G  P P ST   V +SV    D  P F    + VQV ED  PG
Sbjct: 3176 QVRPQAPLELTVRASDLGT-PIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPG 3234

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
              VL++    R         Y ++SGN +G+F LDA+TG L V + LD+ET+ +Y L + 
Sbjct: 3235 TEVLQLATLTRPGAEKT--GYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292

Query: 476  AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
                    LS+V+  V V + D+N++ P F   P+   VLE+  +G ++L V A D D  
Sbjct: 3293 CSRKSSSSLSDVT-TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGP 3351

Query: 536  DNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS 595
             N+ + Y L G      FTI+   G + VA  LDRE+   YS  + A D G P L     
Sbjct: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTD 3411

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS---VITYQITSGNT 652
            +++ V DVNDN P F Q  Y+  + E++ +G+ V+ +   D D+       +++IT GN 
Sbjct: 3412 IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNN 3471

Query: 653  RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHR 709
             + F +T     G +  A  L  + +  Y L + ASD           + V+VT+ + + 
Sbjct: 3472 GSAFRVTPD---GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYA 3528

Query: 710  PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FRIDADTGAV 767
            P        + V ED   G  V  I ATD D  +    +   E+++ + F + A  G +
Sbjct: 3529 PSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKI 3587



 Score =  231 bits (590), Expect = 6e-60
 Identities = 239/954 (25%), Positives = 399/954 (41%), Gaps = 121/954 (12%)

Query: 247  LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
            L+RE + ++   + A +  +    AL  + + + D ND  P+F    Y+ ++ E++ +  
Sbjct: 107  LNREVRDSYTLIIQATEKTL-ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKS 165

Query: 307  EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
             +  V ATD D   NA   Y        + SE+F I P SGV+   G ++      ++L 
Sbjct: 166  PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220

Query: 367  VEASDQGR---DPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
            V A D+ R   +     + AA+ + VE      P  +    VV    D   G     V  
Sbjct: 221  VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIAS---VVVTPPDSNDGTTYATVLV 277

Query: 424  SDRDKGSNAVVHYSIMSGNARGQFYL---DAQTGALDVVSPLD---YETTKEYTLRVRAQ 477
                 G+  V    ++ G+    F      A++    +VS  D    E    + L ++A+
Sbjct: 278  DANSSGAE-VESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQAR 336

Query: 478  DGGRPPL-SNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
             G  P   S + G     +     ++  F    ++  + E  P G  V+ V+   A    
Sbjct: 337  SGSGPYFYSQIRGF---HLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA---- 389

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
               L+Y L     +  F +N  TG I+    +D  +   Y   +      T    AS  V
Sbjct: 390  FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQASTVV 444

Query: 597  SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRN 654
             + ++D N++ P F +  Y   L+E+   GTSV+ V+A DRD   +  +TY I +G    
Sbjct: 445  VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKAL 503

Query: 655  RFSITSQSGGGLVSLALPLDYKL-ERQYVLAVTASDG----TRQDTAQIVVNVTDANTHR 709
             FSI      G++S + P+DY+L +R Y   V ASD      R+    I + + + N ++
Sbjct: 504  PFSIDPYL--GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561

Query: 710  PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTT 769
            P+F+  + T ++ +D P G +++ +SA D D  +N +      + +  F ++  +G ++ 
Sbjct: 562  PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISL 621

Query: 770  Q---AELDYEDQVSYTLAITARD----------------------------NGI------ 792
            +     L      SY+L ITA D                             G+      
Sbjct: 622  KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681

Query: 793  ----------PQKSDTTYLEILVNDVNDNAPQFLRDSYQGS--VYEDVPPFTSVLQISAT 840
                       + SD  +  +    +N   PQF  D +  S  V E VP  T + +++AT
Sbjct: 682  TILHFIGLQNQESSDEEFTSLSTYQINHYTPQF-EDHFPQSIDVLESVPINTPLARLAAT 740

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900
            D D+G NG++ Y    G++ +G F +E  +G++     LD E    Y+L     D G P 
Sbjct: 741  DPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQ 799

Query: 901  ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960
              +   +TV V D NDN P F    + + + E++ +G  +A +T  D D   N ++ Y +
Sbjct: 800  KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL 859

Query: 961  VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAP-----LVSRATVHVRLLD 1015
            +     E F L   +GEL     LD E  P Y+L ++A   P     L S   + + L D
Sbjct: 860  LSPT--EKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLED 917

Query: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLL 1075
             NDN P      I  +N +       PG  +  + A DPD+  +         E+  VL+
Sbjct: 918  VNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA--------GEVRYVLM 965

Query: 1076 NAS---------TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTII 1120
            + +         TG L L R LD  R     +S+  SDG   +  +    V +I
Sbjct: 966  DGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVI 1019



 Score =  160 bits (406), Expect = 1e-38
 Identities = 197/754 (26%), Positives = 309/754 (40%), Gaps = 111/754 (14%)

Query: 434  VHYSIMSGNARGQF-----------YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
            V Y I+SG+    F           +L  +T + +    L+ E    YTL ++A +  + 
Sbjct: 69   VRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTAL-LNREVRDSYTLIIQATE--KT 125

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
                    V V +LD ND  P+F    ++ T+ E +PL   +  V A DAD G NA  E+
Sbjct: 126  LELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNA--EF 183

Query: 543  RLAGVGHDFPFTINNGTGWISVAAELD-----------------REEVDFYSFGVEAR-- 583
              A       F I+  +G ++VA +L+                 R+  +   FG  A   
Sbjct: 184  YYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALV 243

Query: 584  DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVI 643
             H  PAL    +++  V+   D+N   T     V  N   A   SV  V   D   H   
Sbjct: 244  VHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGG-DPGKH--- 299

Query: 644  TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVT 703
               I S    N FS+ S      V     ++Y       L   +  G    +     ++ 
Sbjct: 300  FKAIKSYARSNEFSLVS------VKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP 353

Query: 704  DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRID 761
             +      F+ + Y V ++E  P G+ VV++  T         + Y ++ S     F+++
Sbjct: 354  PSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLN 409

Query: 762  ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
            A TG +TT   +D+ D+  Y L I        Q S    ++I+  D N++AP F R SY 
Sbjct: 410  ARTGLITTTKLMDFHDRAHYQLHIRTSPG---QASTVVVIDIV--DCNNHAPLFNRSSYD 464

Query: 822  GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
            G++ E++PP TSVL ++ATDRD G NG V Y+  G       F ++   GI+ T + +D 
Sbjct: 465  GTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDY 522

Query: 882  ENVAQ-YVLRAYAVDKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            E + + Y  R  A D G P  R   + + + + ++NDN P+FE+      + ++ P+G +
Sbjct: 523  ELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKS 582

Query: 940  VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVDLDYEDRPEYVLVI 996
            +  ++A D DE  N  + Y+IV GN  E F L+ FSG ++     ++L       Y L I
Sbjct: 583  IMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKI 640

Query: 997  QAT-----SAPLVSRATV----HVRLLDRNDNPPVLGNF--------------------- 1026
             A+     ++P     TV    H  +    D   VL  F                     
Sbjct: 641  TASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFT 700

Query: 1027 ---EILFNNYVTNRSSSFP-----------GGAIGRVPAHDPD--ISDSLTYSFERGNEL 1070
                   N+Y       FP              + R+ A DPD   +  L Y    GNE 
Sbjct: 701  SLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEE 760

Query: 1071 SLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
                +   TG L ++  LD       I++V V D
Sbjct: 761  GCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794



 Score =  121 bits (304), Expect = 9e-27
 Identities = 151/626 (24%), Positives = 262/626 (41%), Gaps = 71/626 (11%)

Query: 563  SVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED 622
            S  A L+RE  D Y+  ++A +  T  L A   V V +LD ND  P F+ P Y V ++ED
Sbjct: 102  SNTALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160

Query: 623  AAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYV 682
              + + +  V+A D D      +          F+I   S  G+V++A  L+     ++ 
Sbjct: 161  MPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTS--GVVTVAGKLNVTWRGKHE 218

Query: 683  LAVTASDGTRQ--------DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLI 734
            L V A D  R+          A +VV+V  A    P   S   T   + D     TV++ 
Sbjct: 219  LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278

Query: 735  SATDEDTGENARIT------YFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITAR 788
            + +     E+  +       +F   +I  +    +   V+ +     E    + L++ AR
Sbjct: 279  ANSSGAEVESVEVVGGDPGKHF--KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQAR 336

Query: 789  DNGIPQKSDTTYLEIL---VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSG 845
                P      Y +I    +     ++ +F +  Y+  + E  PP + V+ +  T     
Sbjct: 337  SGSGPY----FYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN 392

Query: 846  LNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPM 905
            L     Y  +   +  G F + + +G++ T + +D  + A Y L          P +   
Sbjct: 393  LQ----YVLKPSSENVG-FKLNARTGLITTTKLMDFHDRAHYQLHIRT-----SPGQAST 442

Query: 906  EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI 965
             V + ++D N++ P+F +  +D  ++EN P G +V  VTATD D G N  + Y I  G  
Sbjct: 443  VVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA-GPK 501

Query: 966  PEVFQLDIFSGELTALVDLDYE-DRPEYVLVIQAT--SAPL--VSRATVHVRLLDRNDNP 1020
               F +D + G ++    +DYE  +  Y   ++A+   +P       ++ ++L + NDN 
Sbjct: 502  ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561

Query: 1021 PVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAST 1079
            P+   FE +  N   +    +P G +I  + A D D   +L Y    GNEL    LN  +
Sbjct: 562  PM---FEEV--NCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFS 616

Query: 1080 GELKLSRALDN---NRPLEAIMSVLVSDGVHSVTAQCALRVTIITD-------------- 1122
            G + L R   N    +P    + +  SDG  +  +   L +T++ D              
Sbjct: 617  GVISLKRPFINLTAGQPTSYSLKITASDG-KNYASPTTLNITVVKDPHFEVPVTCDKTGV 675

Query: 1123 -----EMLTHSITLRLEDMSPERFLS 1143
                 + + H I L+ ++ S E F S
Sbjct: 676  LTQFTKTILHFIGLQNQESSDEEFTS 701



 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 110/493 (22%), Positives = 202/493 (40%), Gaps = 68/493 (13%)

Query: 610  FTQPEYTVRLNEDAAVGTSVVTVSAVD---RDAHSVITYQITSGNTRNRFSITSQSGGGL 666
            FT   Y   + E+++  T V +   +     +    + Y+I SG+  N F       G  
Sbjct: 33   FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92

Query: 667  VSLALP--------LDYKLERQYVLAVTASDGTRQDTA--QIVVNVTDANTHRPVFQSSH 716
              L +         L+ ++   Y L + A++ T +  A  ++VV++ D N  +P+F    
Sbjct: 93   CFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPS 152

Query: 717  YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE 776
            Y V ++ED P  + +  ++ATD D G+NA   Y        F I   +G VT   +L+  
Sbjct: 153  YRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVT 212

Query: 777  DQVSYTLAITARD--NGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
             +  + L + A D    I + +    L  LV  V    P   +     SV    P     
Sbjct: 213  WRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE---PALRKPPAIASVVVTPPDSNDG 269

Query: 835  LQISATDRDSGLNGRVFYTFQ--GGDDGDGDFIVESTSG-------IVRTLRRLDRENVA 885
               +    D+  +G    + +  GGD G     ++S +         V+ +  ++  +  
Sbjct: 270  TTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGF 329

Query: 886  QYVLRA--------YAVDKG--MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
               L+A        Y+  +G  +PP++              +   FE+  + V + E SP
Sbjct: 330  NLSLQARSGSGPYFYSQIRGFHLPPSKL-------------SSLKFEKAVYRVQLSEFSP 376

Query: 936  IG--LAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYV 993
             G  + + RVT   P    N Q + +    N+   F+L+  +G +T    +D+ DR  Y 
Sbjct: 377  PGSRVVMVRVTPAFP----NLQYVLKPSSENVG--FKLNARTGLITTTKLMDFHDRAHYQ 430

Query: 994  LVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSF-PGGAIGRVPAH 1052
            L I+  ++P  +   V + ++D N++ P+        ++Y      +  PG ++  V A 
Sbjct: 431  LHIR--TSPGQASTVVVIDIVDCNNHAPLFNR-----SSYDGTLDENIPPGTSVLAVTAT 483

Query: 1053 DPDISDS--LTYS 1063
            D D  ++  +TYS
Sbjct: 484  DRDHGENGYVTYS 496



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 81/330 (24%), Positives = 120/330 (36%), Gaps = 59/330 (17%)

Query: 1568 VPGCPAKKNVCDSNTCHN--------GGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHF 1619
            +P  P +   C    CHN        G T        S   P     +SC+        F
Sbjct: 3722 MPMVPCQGPTCQGQICHNTVHLDPKVGPTYSTA--RLSILTPRHHLQRSCSCN-GTATRF 3778

Query: 1620 LGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEG 1679
             G S V +     P ++ W++    +T Q   +LL   T   ++++L+L  G   L    
Sbjct: 3779 SGQSYVRYRA---PAARNWHIHFYLKTLQPQAILL--FTNETASVSLKLASGVPQLEYHC 3833

Query: 1680 TGLQASSLRLEPGRANDGDWHHA---------QLALGASGGPGHAILSFDYGQQRAEGNL 1730
             G    +L  +    ND +WH           +L + + G     +       +   G L
Sbjct: 3834 LGGFYGNLSSQR-HVNDHEWHSILVEEMDASIRLMVDSMGNTSLVV------PENCRG-L 3885

Query: 1731 GPRLHGLHLSNITVGGIP--GPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHG-----E 1783
             P  H      + +GG+     +  V++GF GCL  V V++  E ++ L P        E
Sbjct: 3886 RPERH------LLLGGLILLHSSSNVSQGFEGCLDAVVVNE--EALDLLAPGKTVAGLLE 3937

Query: 1784 SINVEQGCSLPDPCDSNPCPANSYCSNDWD---SYSCSCDPGYYGDNCTNV---CDLNPC 1837
            +  + Q C   D C  N C     CS  W     Y C C P + G +C      C   PC
Sbjct: 3938 TQALTQCCLHSDYCSQNTCLNGGKCS--WTHGAGYVCKCPPQFSGKHCEQGRENCTFAPC 3995

Query: 1838 EHQSVCTRKPSAPHGYTCECPPNYLGPYCE 1867
                 C   P    G +C CP  Y G  CE
Sbjct: 3996 LEGGTCILSPK---GASCNCPHPYTGDRCE 4022



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 27/67 (40%), Positives = 35/67 (52%), Gaps = 2/67 (2%)

Query: 1271 GLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSG 1330
            G  C+CPP F+G +CE   + C   PC   G C     G +C C   YTG+ CE+ AR  
Sbjct: 3969 GYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG- 4027

Query: 1331 RCTPGVC 1337
             C+ G C
Sbjct: 4028 -CSEGHC 4033



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 44/144 (30%), Positives = 62/144 (43%), Gaps = 13/144 (9%)

Query: 1285 CETEVDLCYSRPCGPHGRCRSREG-GYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTC 1343
            C    D C    C   G+C    G GY C C   ++G+HCE    +  CT   C  GGTC
Sbjct: 3944 CCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGREN--CTFAPCLEGGTC 4001

Query: 1344 VNLLVGGFKCDCPSGDFEKPYCQVTTRS-FPAHSFITFR------GLRQRFHFTLALSFA 1396
            + L   G  C+CP   +    C++  R     H  +T        G ++    T+A++F 
Sbjct: 4002 I-LSPKGASCNCPH-PYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFI 4059

Query: 1397 TKERDGLLLYNGRFNEKHDFVALE 1420
                 GLL Y  R  + H  VA+E
Sbjct: 4060 IISTVGLLFYCRRC-KSHKPVAME 4082



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 58/214 (27%), Positives = 86/214 (40%), Gaps = 31/214 (14%)

Query: 1414 HDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQG 1473
            H    L+ +Q Q  L F+    T +VS  +  GV   ++H +   Y      G     + 
Sbjct: 3795 HIHFYLKTLQPQAILLFT--NETASVSLKLASGVPQLEYHCLGGFY------GNLSSQRH 3846

Query: 1474 PSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPE 1533
             ++ +   + V+  D  + L   S +GN S        G +    L    LLGG+  L  
Sbjct: 3847 VNDHEWHSILVEEMDASIRLMVDS-MGNTSLVVPENCRGLRPERHL----LLGGLILLHS 3901

Query: 1534 SFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPG---------CPAKKNVCDSNTCH 1584
            S  V  + F GC+  + V+   +D+   +A   TV G         C    + C  NTC 
Sbjct: 3902 SSNVS-QGFEGCLDAVVVNEEALDL---LAPGKTVAGLLETQALTQCCLHSDYCSQNTCL 3957

Query: 1585 NGGTCVNQWD---AFSCECPLGFGGKSCAQEMAN 1615
            NGG C   W     + C+CP  F GK C Q   N
Sbjct: 3958 NGGKC--SWTHGAGYVCKCPPQFSGKHCEQGREN 3989



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 51/201 (25%), Positives = 81/201 (40%), Gaps = 13/201 (6%)

Query: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD----------RDSGLNGRVFYTFQGG 857
           ++ +A  F    Y  ++YE+  P T V                 R   ++G V   F+  
Sbjct: 26  LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85

Query: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
           +   G+F              L+RE    Y L   A +K +        V V +LD ND 
Sbjct: 86  EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDL 144

Query: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P+F    + V + E+ P+   + +VTATD D G NA+  Y        E+F +   SG 
Sbjct: 145 KPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF--NTRSEMFAIHPTSGV 202

Query: 978 LTALVDLDYEDRPEYVLVIQA 998
           +T    L+   R ++ L + A
Sbjct: 203 VTVAGKLNVTWRGKHELQVLA 223



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 56/294 (19%)

Query: 917  NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIF-- 974
            N  ++E      +VE    +G+ +A              + Y+I+ G++  VF+ + +  
Sbjct: 39   NATIYENSSPKTYVESFEKMGIYLAE---------PQWAVRYRIISGDVANVFKTEEYVV 89

Query: 975  ----------SGELTALVDLDYEDRPEYVLVIQATSAPL----VSRATVHVRLLDRNDNP 1020
                          TAL  L+ E R  Y L+IQAT   L    ++R  VH+  LD+ND  
Sbjct: 90   GNFCFLRIRTKSSNTAL--LNREVRDSYTLIIQATEKTLELEALTRVVVHI--LDQNDLK 145

Query: 1021 PVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAST 1079
            P+         +Y    S   P    I +V A D D+  +  + +       +  ++ ++
Sbjct: 146  PLFSP-----PSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTS 200

Query: 1080 GELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPE 1139
            G + ++  L+           +   G H +      R+  I++     S+   +  + P 
Sbjct: 201  GVVTVAGKLN-----------VTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPA 249

Query: 1140 RFLSPLLGLFIQAVAATLATPPDH---VVVFNVQRDTDAPGGHILNVSLSVGQP 1190
                P       A+A+ + TPPD         V  D ++ G  + +V +  G P
Sbjct: 250  LRKPP-------AIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDP 296


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score =  399 bits (1025), Expect = e-110
 Identities = 307/959 (32%), Positives = 455/959 (47%), Gaps = 37/959 (3%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG-RLEYTMDALFDSRSNQFFSLDP 236
            +P FQ      +V EN P GT V    A D D      R++Y +++   +     F + P
Sbjct: 1052 SPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES--HNPGTNPFLIHP 1109

Query: 237  VTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVTDTNDHDPVFEQQE 293
              G + T   LDRE+  T +  VTA D  +    RR    T  I++ D NDH+P F    
Sbjct: 1110 SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP 1169

Query: 294  YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
                ++E++ VG  V  + A D D   N  + Y +L G+    +  F +D  SG++ T  
Sbjct: 1170 -NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN---ENMTFMLDESSGLLTTTC 1225

Query: 354  PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
            P+D E    + LTV A D G      S T  V  +V D ND AP F +  Y   V+E+  
Sbjct: 1226 PLDYEMKTQHILTVLALDDGTPALSSSQTLTV--TVLDVNDEAPVFKQHLYEASVKENQN 1283

Query: 414  PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
            PG  V RV A DRD G N+ + + IM G +   F +++ TG +   + LD E  + +TLR
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343

Query: 474  VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
            V  +DGG P LS+ + ++   V D ND+AP F+ + +   VLE+     +V  V A D D
Sbjct: 1344 VLVRDGGFPSLSSTTTILCT-VEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMD 1401

Query: 534  AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
            AG+N  +EY +     D  FTIN  +G +S    LDRE++  ++  +   D G P  ++ 
Sbjct: 1402 AGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSV 1461

Query: 594  ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
              + V VLD ND++P+F    Y   + EDA VGT V+ +SAVD+D   +    Y +T   
Sbjct: 1462 IHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-E 1520

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD----GTRQDTAQIVVNVTDANT 707
                F+I   S  G +  +  LD +   Q+  +  A D    G+R  T  I V VTD N 
Sbjct: 1521 ASGAFTIDPMS--GTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAV 767
            + PV + + + V ++ + P   T V++ A D D G N  + +   ++   F ID  TG +
Sbjct: 1579 NDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEI 1638

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
              Q     E      L +   D GIP ++ TT L ++  +  D    F    Y+G V E+
Sbjct: 1639 QFQQNPSSE-YFPIWLQLKVTDQGIPART-TTGLLVIHMEGEDVKISFSHHLYKGLVTEN 1696

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
                TS++ + A   DS  +   +  F G +DG      +S    V+  + LD E   + 
Sbjct: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
             L   A   G    R   +V V + D NDN P FEQ  +   V E+      V +V ATD
Sbjct: 1757 QLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATD 1813

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT--SAPLVS 1005
             D G N  I Y I+ GN  E FQ+D  SG +T    LDYE    Y L++QAT    P +S
Sbjct: 1814 LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLS 1873

Query: 1006 RATV-HVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSF 1064
              TV  V++ D NDN P       L +  V     S PG  +  V  HD D++ +  +SF
Sbjct: 1874 NTTVIKVQVTDINDNAPA-----FLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928

Query: 1065 -ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
             +  N  +   ++ +TG + L + LD     E  + + +SD VH       +RV  + D
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVND 1987



 Score =  385 bits (988), Expect = e-106
 Identities = 301/956 (31%), Positives = 453/956 (47%), Gaps = 58/956 (6%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            +P F    YQ++V E+   GT V  L A+D DEG  G+ EY +       ++  F++DP+
Sbjct: 1475 SPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT----DEASGAFTIDPM 1530

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKE 296
            +G + T+  LDRE +S H F   A+D  +   RS    + + VTD ND+DPV EQ  +  
Sbjct: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             L          + VRA D D  PN  +++   E        +F ID  +G I+ +    
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE-----TQSMFSIDKYTGEIQFQQNPS 1645

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
             E    + L ++ +DQG    P  TT  + +   +  D    FS   Y   V E+   G 
Sbjct: 1646 SEYFPIW-LQLKVTDQGI---PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGT 1701

Query: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYETTKEYTLRV 474
             ++ V A   D   +++  YSI SGN  G   L +++G L V  P  LD+E   E  L V
Sbjct: 1702 SIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV 1760

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
             A+  G      V+ L+     D NDN+P F  + +QA+V ES      V+ V A D D+
Sbjct: 1761 LAESSGHRAYCKVAVLIQ----DENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS 1816

Query: 535  GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
            G N  +EY +     +  F I+  +G I+  A LD E    YS  V+A D G P L+ + 
Sbjct: 1817 GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTT 1876

Query: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITS-GNTR 653
             + V V D+NDN P F  P   V + ED+  G  V  VS  D D +S   +      N  
Sbjct: 1877 VIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPG 1935

Query: 654  NRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQ 713
             +F+I   +G  +V L   LD++   +Y L +  SD        +VV V D N + PVF 
Sbjct: 1936 TKFAIDQNTG--VVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFS 1993

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAEL 773
               Y V V E  P G +V+ +SATD ++ EN  I+Y +  S  +F ID   G + T + +
Sbjct: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNGTIFTISPV 2051

Query: 774  DYEDQVSYT-LAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
               D +S T   + A D G P     T +EI + D+N+ AP+F   SY  S+ ED    +
Sbjct: 2052 LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGS 2111

Query: 833  SVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTS----------GIVRTLRRLDR 881
            +++  S  D D +  N  V Y+   G+    +F VE+            G +  L  LDR
Sbjct: 2112 TLVTFSNIDHDWTRENTYVEYSIISGNS-QNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170

Query: 882  ENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941
            E  A + L   A D G PP  +   +++ VLDVNDNPP F    +   V+E++P+G  + 
Sbjct: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230

Query: 942  RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA 1001
             V+A D D G++A+I+Y I+ GN    F L+  +G L  +  LDYE   ++ L +QA+ A
Sbjct: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290

Query: 1002 PL--VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDIS- 1057
                 S A V V +LD ND+ P     + +F+++      + P    I  + A D D   
Sbjct: 2291 EKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345

Query: 1058 -DSLTYSF--------ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
               LTYS             +  L L++  TG++   + LD     +  ++V   D
Sbjct: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401



 Score =  362 bits (930), Expect = 2e-99
 Identities = 297/920 (32%), Positives = 442/920 (48%), Gaps = 45/920 (4%)

Query: 190  VPENQPAGTPVASLRAIDP-DEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELD 248
            +PEN      ++ +++ D   +   G+L +++ A  D +   F  +D  TG +  ++ELD
Sbjct: 957  IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVA--DDKDGHF-EIDSSTGDLFLSKELD 1013

Query: 249  RETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYE 307
             ET S ++FRV   DH      S+   L+I V D NDH P F+ +    S+ EN+ +G  
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTL 1073

Query: 308  VLTVRATDGDAP-PNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
            V    A D D    N+ I Y +   + G  +  F I P  G + T   +DRE + +  LT
Sbjct: 1074 VYVFNAKDDDGSFLNSRIQYYIESHNPG--TNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131

Query: 367  VEASDQG---RDPGPRSTTA-AVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422
            V ASDQ     D   RS TA  V L V D N     F        V+EDVT G+ V  +T
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN----AHVKEDVTVGSLVHHIT 1187

Query: 423  ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
            A D D+G N  V YSI+SGN    F LD  +G L    PLDYE   ++ L V A D G P
Sbjct: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
             LS+ S  +TV VLD+ND AP+F    ++A+V E+   G  V  V+A+D D+G N++L++
Sbjct: 1248 ALSS-SQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306

Query: 543  RLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             +        F IN+ TG +     LDRE  + ++  V  RD G P+L+++ ++  TV D
Sbjct: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366

Query: 603  VNDNNPTFTQPEYTVRL--NEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSI 658
             ND+ P F    Y + +  N++  V   V TV A D DA  +  + Y I  GNT   F+I
Sbjct: 1367 ENDHAPEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTI 1423

Query: 659  TSQSGGGLVSLALPLDYKLERQYVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVFQSS 715
               SG   +S    LD +    + L +  S   D  R     + V V DAN H P F + 
Sbjct: 1424 NEMSGE--LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481

Query: 716  HYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDADTGAVTTQAELD 774
            +Y  +V ED   GT V+++SA D+D G N +  YF+ D     F ID  +G + T   LD
Sbjct: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLD 1541

Query: 775  YEDQVSYTLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
             E +  +T +  ARD  I   +S T  +++ V DVNDN P   ++ +   +  + P   +
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQT 1601

Query: 834  VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
             + + A D D G NG V ++F    +    F ++  +G ++  +    E    + L+   
Sbjct: 1602 TVIVRADDLDLGPNGTVVFSFA---ETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKV 1657

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D+G+ PART   + V  ++  D    F    +   V EN   G ++  V A  PD    
Sbjct: 1658 TDQGI-PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQ 1715

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVD--LDYEDRPEYVLVIQATSAPLVSRATVHV 1011
              + Y I  GN   V  L   SG+LT      LD+E R E  L++ A S+   +   V V
Sbjct: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAV 1775

Query: 1012 RLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNE 1069
             + D NDN P    FE        + S  +    I +V A D D  ++  + YS   GN+
Sbjct: 1776 LIQDENDNSPC---FEQSIYQASVSESQLYNAHVI-QVFATDLDSGLNGLIEYSILSGNQ 1831

Query: 1070 LSLVLLNASTGELKLSRALD 1089
                 ++A +G +     LD
Sbjct: 1832 EEAFQIDALSGVITTKAILD 1851



 Score =  358 bits (918), Expect = 6e-98
 Identities = 296/953 (31%), Positives = 446/953 (46%), Gaps = 43/953 (4%)

Query: 190  VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
            V E QP    V ++ A DPDEG    + Y++ +     S+  F +D   G + T   L  
Sbjct: 852  VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDHFKIDANNGEIRTTTILSY 908

Query: 250  ETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVL 309
            + + ++   V A D G+P     A + I V   +    +  Q      + ENL+    + 
Sbjct: 909  DYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMS 968

Query: 310  TVRATDG-DAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
             ++++D      N  + + ++          FEID  +G +     +D E    Y   V 
Sbjct: 969  LIKSSDHLQQHYNGKLHFSIV---ADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025

Query: 369  ASDQGRDPGPRSTTAAVFLS--VEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDR 426
             +D  ++    S ++ VFLS  VED ND++P F ++  V+ V E+V  G  V    A D 
Sbjct: 1026 TTDHSKN---LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD- 1081

Query: 427  DKGS--NAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPP 483
            D GS  N+ + Y I S N     F +    G L  VS LD E+     L V A D     
Sbjct: 1082 DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNV 1141

Query: 484  LSNVSGLVTVQ--VLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLE 541
                   +T Q  +LD+ND+ P F+S P  A V E V +G LV H+ A D D G N ++ 
Sbjct: 1142 TDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVT 1200

Query: 542  YRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVL 601
            Y +     +  F ++  +G ++    LD E    +   V A D GTPAL++S +++VTVL
Sbjct: 1201 YSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260

Query: 602  DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSIT 659
            DVND  P F Q  Y   + E+   G  V  V A+DRD+  +S + ++I  G +   F I 
Sbjct: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320

Query: 660  SQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSH 716
            S +G   V     LD +++  + L V   DG   +   T  I+  V D N H P F  S 
Sbjct: 1321 SDTGE--VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS 1378

Query: 717  YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELD 774
            Y + V E++     V  + A+D D G N  + Y + D      F I+  +G ++T   LD
Sbjct: 1379 YDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALD 1437

Query: 775  YEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
             E   ++TL I   D G P +S   +L++ V D ND++P F    YQ SV ED    T V
Sbjct: 1438 REQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV 1497

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
            L +SA D+D GLNG+  Y     D+  G F ++  SG ++T   LDRE  +Q+   A A 
Sbjct: 1498 LVLSAVDKDEGLNGQTEYFLT--DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVAR 1555

Query: 895  DKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
            D  +  +R T + + V V DVNDN PV EQ+ FDVF+   SP       V A D D G N
Sbjct: 1556 DCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPN 1615

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRL 1013
              +++   E     +F +D ++GE+    +   E  P + L ++ T   + +R T  + +
Sbjct: 1616 GTVVFSFAE--TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLV 1672

Query: 1014 LDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD-ISDSLTYSFERGNELSL 1072
            +        +     L+   VT    +  G +I  V A  PD I DS+ YS   GNE  +
Sbjct: 1673 IHMEGEDVKISFSHHLYKGLVTENCEA--GTSIVTVKAFAPDSIQDSMKYSIFSGNEDGV 1730

Query: 1073 VLLNASTGEL--KLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDE 1123
            + L + +G+L  K  + LD     E  + VL     H   A C + V +I DE
Sbjct: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH--RAYCKVAV-LIQDE 1780



 Score =  354 bits (908), Expect = 8e-97
 Identities = 257/803 (32%), Positives = 402/803 (50%), Gaps = 55/803 (6%)

Query: 186  YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAE 245
            Y+  V EN  AGT + +++A  PD  +   ++Y+   +F    +   SL   +G +T  E
Sbjct: 1689 YKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYS---IFSGNEDGVLSLCSKSGQLTVKE 1744

Query: 246  E--LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLE 303
               LD E ++     V A+  G     A   + +L+ D ND+ P FEQ  Y+ S+ E+  
Sbjct: 1745 PKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801

Query: 304  VGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESY 363
                V+ V ATD D+  N  I Y +L G+     E F+ID  SGVI T+  +D E   SY
Sbjct: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGN---QEEAFQIDALSGVITTKAILDYELTSSY 1858

Query: 364  QLTVEASDQGRDPGPR-STTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422
             L V+A+D+G    PR S T  + + V D NDNAP F      V++ ED  PG  V  V+
Sbjct: 1859 SLIVQATDKGM---PRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVS 1914

Query: 423  ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
              D D  S  +  ++  S N   +F +D  TG + +V  LD+E   EY L ++  D    
Sbjct: 1915 VHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS--- 1970

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
             +    G + V+VLD+NDN P+F    +Q TV ES+P+GY VL + A D ++ +N  + Y
Sbjct: 1971 -VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISY 2027

Query: 543  RLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
            R+     +F     NGT + +++  L  + +    F VEA D G P L A   V + + D
Sbjct: 2028 RILSSSKEFSIDPKNGTIF-TISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIED 2086

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD---AHSVITYQITSGNTRNRFSIT 659
            +N+  P FT   Y + L+EDA VG+++VT S +D D    ++ + Y I SGN++N F + 
Sbjct: 2087 MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146

Query: 660  SQ--------SGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
            ++           G + L   LD +    + L + ASD        TA I + V D N +
Sbjct: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206

Query: 709  RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY--FMEDSIPQFRIDADTGA 766
             P F S  Y  +V E  P G+ + ++SA D DTG +A I Y     +    F ++ +TG 
Sbjct: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGV 2266

Query: 767  VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVN--DVNDNAPQFLRDSYQGSV 824
            +     LDYE    +TL + A D    +K   ++  + V+  D ND+APQF+  S+   V
Sbjct: 2267 LYLIKPLDYEKMTKFTLTVQASD---AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIV 2323

Query: 825  YEDVPPFTSVLQISATDRDSGLNGRVFYTFQG------GDDGDGD-FIVESTSGIVRTLR 877
             E++P  +++  I+A D D+G  G + Y+         G   D D F+++  +G +   +
Sbjct: 2324 PENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQ 2383

Query: 878  RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
             LD EN  +Y L   A DKG   A   + V V +  +++  P+F QD++   + E +   
Sbjct: 2384 ILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441

Query: 938  LAVARVTATDPDEGTNAQIMYQI 960
              + RV A+D D G +  I+Y +
Sbjct: 2442 QLIGRVEASDADAGIDGVILYSL 2464



 Score =  348 bits (894), Expect = 3e-95
 Identities = 290/955 (30%), Positives = 437/955 (45%), Gaps = 91/955 (9%)

Query: 200  VASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG------AVTTAE-------- 245
            +  + AID D G+ G+L Y     F     +FF ++P TG       +T A+        
Sbjct: 711  IGKITAIDMDSGKNGQLLY-----FLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGT 765

Query: 246  ------------------------------ELDRETKSTHVFRVTAQDHGMPRRSALATL 275
                                           LDRE +  H   V   D G P R+A   +
Sbjct: 766  DFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 825

Query: 276  TILVTDTNDHDPVFEQ----QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG 331
             + VTD ND+ P F Q    +E    + E   V   V TV A D D   NA + Y +   
Sbjct: 826  YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV--- 882

Query: 332  SGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVED 391
            S    S+ F+ID  +G IRT   +  +   SY+++V A+DQG  P      A V + V  
Sbjct: 883  SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPP--LQGQAVVNIQVIP 940

Query: 392  DNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDR-DKGSNAVVHYSIMSGNARGQFYLD 450
             +      S+    + + E++ P   +  + +SD   +  N  +H+SI++ +  G F +D
Sbjct: 941  LSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEID 1000

Query: 451  AQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPF 510
            + TG L +   LDYETT  Y  RV   D  +    + +  +++ V D ND++P F     
Sbjct: 1001 SSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060

Query: 511  QATVLESVPLGYLVLHVQAIDADAGD-NARLEYRLAGVGHDF-PFTINNGTGWISVAAEL 568
              +V E+VP+G LV    A D D    N+R++Y +        PF I+   G +   + L
Sbjct: 1061 VISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRL 1120

Query: 569  DREEVDFYSFGVEARDHG---TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV 625
            DRE +      V A D     T     S +  + +LDVND+NPTF        + ED  V
Sbjct: 1121 DRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTV 1179

Query: 626  GTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVL 683
            G+ V  ++A D D   +  +TY I SGN    F +   S  GL++   PLDY+++ Q++L
Sbjct: 1180 GSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESS--GLLTTTCPLDYEMKTQHIL 1237

Query: 684  AVTA-SDGT--RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED 740
             V A  DGT     +  + V V D N   PVF+   Y  +V E++  G  V  + A D D
Sbjct: 1238 TVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD 1297

Query: 741  TGENARITYFMED--SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
            +G N+++ + +    S   F I++DTG V T   LD E Q  +TL +  RD G P  S T
Sbjct: 1298 SGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357

Query: 799  TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD 858
            T +   V D ND+AP+F+  SY   V E+  P   V  + A+D D+G N  V Y    G+
Sbjct: 1358 TTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGN 1416

Query: 859  DGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
              D  F +   SG + T R LDRE ++ + L     D G PP  + + + V VLD ND+ 
Sbjct: 1417 T-DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHS 1475

Query: 919  PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978
            P F    +   V E++ +G  V  ++A D DEG N Q  Y + +      F +D  SG L
Sbjct: 1476 PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTL 1534

Query: 979  TALVDLDYEDRPEYVLVIQATSAPLV-SRAT---VHVRLLDRNDNPPVL--GNFEILFN- 1031
                 LD E R ++     A    +  SR+T   + V + D NDN PVL    F++  + 
Sbjct: 1535 KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSP 1594

Query: 1032 NYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSR 1086
               TN+++         V A D D+  + T  F      S+  ++  TGE++  +
Sbjct: 1595 ESPTNQTTVI-------VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQ 1642



 Score =  340 bits (873), Expect = 9e-93
 Identities = 282/943 (29%), Positives = 428/943 (45%), Gaps = 70/943 (7%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P  +   +   +    P       +RA D D G  G + ++      + +   FS+D  T
Sbjct: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-----AETQSMFSIDKYT 1635

Query: 239  GAVTTAEELDRETKSTHVFRVTAQ----DHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            G +       ++  S+  F +  Q    D G+P R+    L I + +  D    F    Y
Sbjct: 1636 GEIQF-----QQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLY 1689

Query: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
            K  + EN E G  ++TV+A   D+  ++ + Y +  G+      V  +  +SG +  + P
Sbjct: 1690 KGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDG---VLSLCSKSGQLTVKEP 1745

Query: 355  --VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
              +D E     QL V A   G           V + ++D+NDN+P F +  Y   V E  
Sbjct: 1746 KFLDFEVRNEVQLIVLAESSGH-----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800

Query: 413  TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
               A V++V A+D D G N ++ YSI+SGN    F +DA +G +   + LDYE T  Y+L
Sbjct: 1801 LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSL 1860

Query: 473  RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
             V+A D G P LSN + ++ VQV DINDNAP F+ +       +S+P G +V HV   D 
Sbjct: 1861 IVQATDKGMPRLSNTT-VIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDV 1918

Query: 533  DAGDNARLEYRLAGVGHD-FPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
            D   N+   +  A   +    F I+  TG + +   LD EE+  Y   ++  D  +   T
Sbjct: 1919 DL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--SVHYT 1974

Query: 592  ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN 651
              A V V VLDVNDN P F+Q  Y V + E   VG SV+T+SA D +++  I+Y+I S +
Sbjct: 1975 EGALV-VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSS 2033

Query: 652  TRNRFSITSQSGGGL-VSLALPLDYKLERQYVLAVTASDGTRQDTAQIV---VNVTDANT 707
                FSI  ++G    +S  L LD     Q++  V ASDG   D   +    + + D N 
Sbjct: 2034 --KEFSIDPKNGTIFTISPVLLLDTISTTQFL--VEASDGGNPDLRALTLVEIGIEDMNN 2089

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITYFMEDSIPQFRIDADT-- 764
            + P F    Y ++++ED   G+T+V  S  D D T EN  + Y +     Q     +T  
Sbjct: 2090 YAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKF 2149

Query: 765  ----------GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQ 814
                      G +     LD E   S+ L I A D+G P  S T  + I V DVNDN P 
Sbjct: 2150 FHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPN 2209

Query: 815  FLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVR 874
            F   SY   V E  P  + +  +SA DRD+G +  + Y    G++  G F +E  +G++ 
Sbjct: 2210 FSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE-KGHFYLEENTGVLY 2268

Query: 875  TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
             ++ LD E + ++ L   A D         + V V+VLD ND+ P F    F   V EN 
Sbjct: 2269 LIKPLDYEKMTKFTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENL 2327

Query: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNI--------PEVFQLDIFSGELTALVDLDY 986
            PI   +  + A D D G   ++ Y IV             ++F +D  +G++ A   LDY
Sbjct: 2328 PISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDY 2387

Query: 987  EDRPEYVLVIQATS-APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
            E+  +Y L +QA       +   V V +   ++  P+    +  F     N+        
Sbjct: 2388 ENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQL---- 2443

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
            IGRV A D D        +  G       +N + G + L RAL
Sbjct: 2444 IGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486



 Score =  315 bits (806), Expect = 5e-85
 Identities = 292/982 (29%), Positives = 448/982 (45%), Gaps = 82/982 (8%)

Query: 178  APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
            AP+F   SY   V ENQ     V ++ A D D G    +EY    + D  +++ F+++ +
Sbjct: 1371 APEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYH---IIDGNTDECFTINEM 1426

Query: 238  TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
            +G ++T   LDRE  S     +   D G P RS++  L + V D NDH P F    Y+ S
Sbjct: 1427 SGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSS 1486

Query: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
            +RE+ EVG  VL + A D D   N    Y L + + G+    F IDP SG ++T   +DR
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA----FTIDPMSGTLKTSNTLDR 1542

Query: 358  EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
            E    +  +  A D     G RSTT  + + V D NDN P   +  + V +  +      
Sbjct: 1543 EARSQHTFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQT 1601

Query: 418  VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT---LRV 474
             + V A D D G N  V +S      +  F +D  TG +          + EY    L++
Sbjct: 1602 TVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQ----FQQNPSSEYFPIWLQL 1655

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            +  D G P  +  +GL+ +  ++  D    F    ++  V E+   G  ++ V+A   D+
Sbjct: 1656 KVTDQGIPARTT-TGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS 1713

Query: 535  GDNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTA 592
              ++ ++Y +     D   ++ + +G ++V     LD E  +     V A   G  A   
Sbjct: 1714 IQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAY-- 1770

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG 650
               V+V + D NDN+P F Q  Y   ++E       V+ V A D D+  + +I Y I SG
Sbjct: 1771 -CKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSG 1829

Query: 651  NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANT 707
            N    F I + SG  +++    LDY+L   Y L V A+D       +T  I V VTD N 
Sbjct: 1830 NQEEAFQIDALSG--VITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIND 1887

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP--QFRIDADTG 765
            + P F  S   V + ED   G  V  +S  D D   +A I  F ++S P  +F ID +TG
Sbjct: 1888 NAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTG 1945

Query: 766  AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY-----LEILVNDVNDNAPQFLRDSY 820
             V     LD+E+   Y L I        Q SD+ +     L + V DVNDN P F +D Y
Sbjct: 1946 VVVLVKTLDFEEMTEYELLI--------QISDSVHYTEGALVVRVLDVNDNPPVFSQDFY 1997

Query: 821  QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR-- 878
            Q +V E +P   SVL +SATD +S  N  + Y          +F ++  +G + T+    
Sbjct: 1998 QVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSK---EFSIDPKNGTIFTISPVL 2052

Query: 879  -LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
             LD  +  Q+++ A   D G P  R    V + + D+N+  P F    +++ + E++ +G
Sbjct: 2053 LLDTISTTQFLVEAS--DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110

Query: 938  LAVARVTATDPD-EGTNAQIMYQIVEGNIPEVFQLD--IFSGE--------LTALVDLDY 986
              +   +  D D    N  + Y I+ GN    F ++   F  E        L  L  LD 
Sbjct: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP- 1042
            E    + LVI A+ +   PL S A + +++LD NDNPP   NF  L  +Y T+   S P 
Sbjct: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP---NFSSL--SYHTHVKESTPL 2225

Query: 1043 GGAIGRVPAHDPDISD--SLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
            G  I  V A+D D      + Y+   GNE     L  +TG L L + LD  +  +  ++V
Sbjct: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285

Query: 1101 LVSDGVHSVTAQCALRVTIITD 1122
              SD      +   + V+++ D
Sbjct: 2286 QASDAEKKHFSFAVVFVSVLDD 2307



 Score =  308 bits (790), Expect = 4e-83
 Identities = 287/994 (28%), Positives = 432/994 (43%), Gaps = 88/994 (8%)

Query: 180  QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
            +F+ P Y   V E+ P  +P+ +++A +P        E     +        FS+ P  G
Sbjct: 376  EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS----EPIFYRISSGDLGGKFSIHPRLG 431

Query: 240  AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
             + T + LD ET+   V  V AQ    P  S+   + I V D ND+ P F +   +  + 
Sbjct: 432  TIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRIS 490

Query: 300  ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
            +    G  +   RA D D+  N  I Y +     G    VF ID   GV+   G +   E
Sbjct: 491  QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGE 546

Query: 360  VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ--FSEKRYVVQVREDVTPGAP 417
                 LT+ A DQG  P        V   V +  +++P   F    Y V+V E ++P   
Sbjct: 547  QRELTLTLRAEDQGVHP---QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQ 603

Query: 418  VLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
            +L+  A     + + + + YS+        F +   TG + +    DYE+T+ Y  RV A
Sbjct: 604  MLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA 663

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLES-VPLGYLVLHVQAIDADAG 535
                   L NVS  V V+V D NDN+P F+       V ES VP G ++  + AID D+G
Sbjct: 664  WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSG 722

Query: 536  DNARLEYRLAGVGHDFPFTINNGTG-------WISVAAE--------------------- 567
             N +L Y L   G  F    N G         W   AA                      
Sbjct: 723  KNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782

Query: 568  --------------LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ- 612
                          LDRE    +   V   D G+P   A+ +V V+V D+NDN P F Q 
Sbjct: 783  FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 842

Query: 613  ---PEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLV 667
                E  V++ E   V   V TV A D D   ++ +TY ++S ++ + F I + +G    
Sbjct: 843  LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRT 902

Query: 668  SLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNVNED 724
            +  L  DY+    Y ++V A+D G      Q VVN  V   +  R +   +   + + E+
Sbjct: 903  TTILSYDYR--PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPEN 960

Query: 725  RPAGTTVVLISATD---EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSY 781
                  + LI ++D   +        +   +D    F ID+ TG +    ELDYE    Y
Sbjct: 961  LKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY 1020

Query: 782  TLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
               +   D+      S T +L I V D ND++P F  +    SV E+VP  T V   +A 
Sbjct: 1021 LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080

Query: 841  DRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGM- 898
            D D S LN R+ Y  +  + G   F++  + G + T+ RLDRE++   +L   A D+ + 
Sbjct: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140

Query: 899  --PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQI 956
                    +   + +LDVND+ P F     +  V+E+  +G  V  +TA DPDEG N ++
Sbjct: 1141 VTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKV 1199

Query: 957  MYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRL 1013
             Y I+ GN    F LD  SG LT    LDYE + +++L + A    +  L S  T+ V +
Sbjct: 1200 TYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTV 1259

Query: 1014 LDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELS 1071
            LD ND  PV    + L+   V  + +  PG  + RV A D D  ++  L +    G    
Sbjct: 1260 LDVNDEAPVFK--QHLYEASV--KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE 1315

Query: 1072 LVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            L  +N+ TGE+  +  LD        + VLV DG
Sbjct: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDG 1349



 Score =  304 bits (778), Expect = 1e-81
 Identities = 271/996 (27%), Positives = 436/996 (43%), Gaps = 91/996 (9%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F   S +  + +  P GT +   RA D D G  G + Y++     S     F++D   
Sbjct: 478  PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA----SPQPGVFAIDRAL 533

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP--VFEQQEYKE 296
            G +     L    +      + A+D G+  ++AL  LT+++ +  +H P   FE   Y+ 
Sbjct: 534  GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQV 592

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             + E+L    ++L  +A        A+ L   LE S    S +F I P +G I  R   D
Sbjct: 593  EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS--VDSAMFGIRPYTGWIYLRRQFD 650

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
             E  ++Y   V A     D   ++ +  V + V D+NDN+P F      ++V E   P  
Sbjct: 651  YESTQTYNFRVFAWIP-EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG 709

Query: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTGALDVVS--------------- 460
             + ++TA D D G N  + Y ++S    G+F+ ++  TG    +                
Sbjct: 710  VIGKITAIDMDSGKNGQLLYFLLSD---GKFFKMNPNTGPAGTIYVITWADGAAAFSGTD 766

Query: 461  -----------------------------PLDYETTKEYTLRVRAQDGGRPPLSNVSGLV 491
                                          LD E    + + V   D G PP  N +  V
Sbjct: 767  FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPP-RNATMAV 825

Query: 492  TVQVLDINDNAPIFVST----PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
             V V DINDN P F            VLE  P+  LV  V A D D G+NA + Y ++  
Sbjct: 826  YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE 885

Query: 548  GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                 F I+   G I     L  +    Y   V A D G P L   A V++ V+ ++   
Sbjct: 886  DSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945

Query: 608  PTFTQPEYTVRLNEDAAVGTSVVTVSAVD---RDAHSVITYQITSGNTRNRFSITSQSGG 664
               +Q    + + E+      +  + + D   +  +  + + I + +    F I S +G 
Sbjct: 946  AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005

Query: 665  GLVSLALPLDYKLERQYVLAVTASDGTRQ----DTAQIVVNVTDANTHRPVFQSSHYTVN 720
              + L+  LDY+    Y+  V  +D ++      T  + ++V D N H P FQ     ++
Sbjct: 1006 --LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVIS 1063

Query: 721  VNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIP---QFRIDADTGAVTTQAELDYE 776
            V E+ P GT V + +A D+D    N+RI Y++E   P    F I    G + T + LD E
Sbjct: 1064 VEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRE 1123

Query: 777  DQVSYTLAITARDNGI---PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
               +  L +TA D  +    ++  +   +I++ DVND+ P F+       V EDV   + 
Sbjct: 1124 SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSL 1182

Query: 834  VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
            V  I+A D D G NG+V Y+   G++ +  F+++ +SG++ T   LD E   Q++L   A
Sbjct: 1183 VHHITAHDPDEGRNGKVTYSILSGNE-NMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
            +D G P   +   +TVTVLDVND  PVF+Q  ++  V+EN   G  V RV A D D G N
Sbjct: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---VLVIQATSAPLVSRATVH 1010
            +++ ++I+ G   E+F+++  +GE+     LD E +  +   VLV       L S  T+ 
Sbjct: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361

Query: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISD--SLTYSFERGN 1068
              + D ND+ P     E + ++Y      +     +  V A D D  +  ++ Y    GN
Sbjct: 1362 CTVEDENDHAP-----EFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGN 1416

Query: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
                  +N  +GEL  +RALD  +     + +L SD
Sbjct: 1417 TDECFTINEMSGELSTTRALDREQISNFTLVILCSD 1452



 Score =  287 bits (735), Expect = 9e-77
 Identities = 217/730 (29%), Positives = 347/730 (47%), Gaps = 51/730 (6%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
            + +P F+   YQA+V E+Q     V  + A D D G  G +EY   ++      + F +D
Sbjct: 1782 DNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY---SILSGNQEEAFQID 1838

Query: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
             ++G +TT   LD E  S++   V A D GMPR S    + + VTD ND+ P F   E  
Sbjct: 1839 ALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV 1898

Query: 296  ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
            E   ++L     V+    +  D   N+  ++   + S  +P   F ID  +GV+     +
Sbjct: 1899 EITEDSLP---GVIVTHVSVHDVDLNSAFIFSFAKES--NPGTKFAIDQNTGVVVLVKTL 1953

Query: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
            D EE+  Y+L ++ SD         T  A+ + V D NDN P FS+  Y V V E +  G
Sbjct: 1954 DFEEMTEYELLIQISD-----SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVG 2008

Query: 416  APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP-LDYETTKEYTLRV 474
              VL ++A+D +  SN  + Y I+S +   +F +D + G +  +SP L  +T       V
Sbjct: 2009 YSVLTLSATDLE--SNENISYRILSSSK--EFSIDPKNGTIFTISPVLLLDTISTTQFLV 2064

Query: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD- 533
             A DGG P L  ++ LV + + D+N+ AP F    +  ++ E   +G  ++    ID D 
Sbjct: 2065 EASDGGNPDLRALT-LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW 2123

Query: 534  AGDNARLEYRLAGVGHDFPFTIN----------NGTGWISVAAELDREEVDFYSFGVEAR 583
              +N  +EY +        F +              G++ +   LDRE    +   + A 
Sbjct: 2124 TRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILAS 2183

Query: 584  DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHS 641
            D G P L+++A +S+ VLDVNDN P F+   Y   + E   +G+ +  VSA DRD  +H+
Sbjct: 2184 DSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHA 2243

Query: 642  VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ--DTAQIV 699
             I Y I SGN +  F +  +   G++ L  PLDY+   ++ L V ASD  ++    A + 
Sbjct: 2244 EIIYNIISGNEKGHFYL--EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF 2301

Query: 700  VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF--------- 750
            V+V D N H P F  S ++  V E+ P  +T+  I+A D D G    +TY          
Sbjct: 2302 VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTH 2361

Query: 751  -MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVN 809
             M      F ID  TG +  +  LDYE+   Y L + A+D G    S   +++I    ++
Sbjct: 2362 GMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDI--EGID 2419

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
            +  P F +D Y  ++ E       + ++ A+D D+G++G + Y+          F V  T
Sbjct: 2420 EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL---GTSSPFFSVNKT 2476

Query: 870  SGIVRTLRRL 879
            +G +  +R L
Sbjct: 2477 NGNIYLIRAL 2486



 Score =  261 bits (667), Expect = 7e-69
 Identities = 261/953 (27%), Positives = 410/953 (43%), Gaps = 90/953 (9%)

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
            G +     L     +T    V+AQD G       A +TI +  T      FE+ +Y   +
Sbjct: 327  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386

Query: 299  RENLEVGYEVLTVRATDGDAPPNAN--ILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             E++     + TV+A +   P N++  I YR+  G  G     F I PR G IRTR P+D
Sbjct: 387  YEDVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTRKPLD 440

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
             E      LTV+A        P  ++  V ++V D NDN P F      +++ +   PG 
Sbjct: 441  HETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497

Query: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
             +    A DRD G N ++ YSI S    G F +D   G L +   L     +E TL +RA
Sbjct: 498  ALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 556

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAP--IFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            +D G  P + +  LV   V++  +++P   F    +Q  V ES+     +L  QA     
Sbjct: 557  EDQGVHPQAAL--LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 614

Query: 535  GDNAR-LEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL-TA 592
               A  L Y L        F I   TGWI +  + D E    Y+F V A       L   
Sbjct: 615  QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 674

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITS- 649
            S +V V V D NDN+PTF      +++ E       +  ++A+D D+  +  + Y + S 
Sbjct: 675  STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 734

Query: 650  ----------GNTRNRFSITSQSGGGLVS------------------------------- 668
                      G     + IT   G    S                               
Sbjct: 735  GKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINW 794

Query: 669  LALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANTHRPVF----QSSHYTVNVNE 723
            +AL  +++   +  + VT      R  T  + V+VTD N +RP F          V V E
Sbjct: 795  VALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE 854

Query: 724  DRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDADTGAVTTQAELDYEDQVSY 781
             +P    V  + A D D G NA +TY +  EDS   F+IDA+ G + T   L Y+ + SY
Sbjct: 855  GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSY 914

Query: 782  TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
             +++ A D G+P       + I V  ++       ++     + E++ P   +  I ++D
Sbjct: 915  RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974

Query: 842  R-DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVD--KGM 898
                  NG++ ++    DD DG F ++S++G +   + LD E  + Y+ R    D  K +
Sbjct: 975  HLQQHYNGKLHFSIV-ADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL 1033

Query: 899  PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG-TNAQIM 957
              + T + +++ V D ND+ P F+ +   + VEEN PIG  V    A D D    N++I 
Sbjct: 1034 SLSST-VFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092

Query: 958  YQIVEGNI-PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPL------VSRATVH 1010
            Y I   N     F +    G L  +  LD E  P  +L + A+   +      +   T  
Sbjct: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152

Query: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGN 1068
            + +LD ND+ P   +F    N +V  +     G  +  + AHDPD   +  +TYS   GN
Sbjct: 1153 IVILDVNDHNPTFISFP---NAHV--KEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN 1207

Query: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVL-VSDGVHSVTAQCALRVTII 1120
            E    +L+ S+G L  +  LD     + I++VL + DG  ++++   L VT++
Sbjct: 1208 ENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260



 Score =  228 bits (581), Expect = 7e-59
 Identities = 253/1008 (25%), Positives = 419/1008 (41%), Gaps = 120/1008 (11%)

Query: 205  AIDPDEGEAGRLEYTM-DALFDSRSNQFFSLDPVTGAVTTAEELDRETK-STHVFRVTAQ 262
            A D D G  G +EY++ D      + Q F +DP  G +  ++++DRE   +T+   V A+
Sbjct: 81   ASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAK 140

Query: 263  DHGMPRR----------SALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVR 312
            D    R           SA A + + + D ND+ PVF    Y  S+ +  + G E++ V 
Sbjct: 141  DGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL 200

Query: 313  ATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV--------DREEVESYQ 364
            ATD D+     + Y L+    G+ S +F ID  +G+      +        D+E + S +
Sbjct: 201  ATDQDSGIYGTVAYELIP---GNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLE 257

Query: 365  LTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTAS 424
            + +                  F  VE D + A +  E      +R         L+V   
Sbjct: 258  MFLPLLRH-------------FKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDE 304

Query: 425  DRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPL 484
                   A   Y        G+       G + +  PL +  +   +L V AQDGG    
Sbjct: 305  AASADGEAAARYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGG-GLT 356

Query: 485  SNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL 544
            + ++  VT+ +         F    +   V E VP    +  V+A +     +  + YR+
Sbjct: 357  AVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRI 415

Query: 545  AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVN 604
            +       F+I+   G I     LD E        V+A+    PA  +S  V++TV+DVN
Sbjct: 416  SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA-CSSTEVNITVMDVN 474

Query: 605  DNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQS 662
            DN+P F +    +R+++    GT++    A DRD+  + +I Y I S      F+I    
Sbjct: 475  DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAI--DR 531

Query: 663  GGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVT-DANTHRPVFQSSH--YT 718
              G++ L   L    +R+  L + A D G     A +V+ V  +   H P +   H  Y 
Sbjct: 532  ALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQ 591

Query: 719  VNVNEDRPAGTTVVLISATDEDTGENAR-ITYFMEDSI--PQFRIDADTGAVTTQAELDY 775
            V V+E     T ++   A        A  + Y +E S+    F I   TG +  + + DY
Sbjct: 592  VEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDY 651

Query: 776  EDQVSYTLAITA--RDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
            E   +Y   + A   ++G  Q   TT + + V D NDN+P FL D     V E   P   
Sbjct: 652  ESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGV 710

Query: 834  VLQISATDRDSGLNGRVFY-------------------------------TFQGGD---- 858
            + +I+A D DSG NG++ Y                                F G D    
Sbjct: 711  IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFS 770

Query: 859  -DGDGDFIVEST-----SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
             D    F+++S       G +     LDRE+   + +     D+G PP    M V V+V 
Sbjct: 771  SDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 830

Query: 913  DVNDNPPVFEQ----DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 968
            D+NDN P F Q     E  V V E  P+ + V  V A DPDEG NA++ Y +   +  + 
Sbjct: 831  DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH 890

Query: 969  FQLDIFSGELTALVDLDYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGN 1025
            F++D  +GE+     L Y+ RP Y + + AT     PL  +A V+++++      P+   
Sbjct: 891  FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI------PLSKG 944

Query: 1026 FEILFNN--YVTNRSSSFPGGAIGRVPAHD---PDISDSLTYSFERGNELSLVLLNASTG 1080
              I+  N  ++    +  P   +  + + D      +  L +S    ++     +++STG
Sbjct: 945  RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTG 1004

Query: 1081 ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHS 1128
            +L LS+ LD       +  V+ +D   +++    + ++I  ++   HS
Sbjct: 1005 DLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052



 Score =  227 bits (579), Expect = 1e-58
 Identities = 186/565 (32%), Positives = 278/565 (49%), Gaps = 44/565 (7%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F    YQ TVPE+ P G  V +L A D +  E   + Y + +     S++ FS+DP  
Sbjct: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNE--NISYRILS-----SSKEFSIDPKN 2042

Query: 239  GAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
            G + T +  L  +T ST  F V A D G P   AL  + I + D N++ P F  + Y  S
Sbjct: 2043 GTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLS 2102

Query: 298  LRENLEVGYEVLTVRATDGD-APPNANILYRLLEGSGGSPSEV----FEID---PRSGVI 349
            L E+  VG  ++T    D D    N  + Y ++ G+  +   V    F  +    + G +
Sbjct: 2103 LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYL 2162

Query: 350  RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
                 +DRE   S++L + ASD G  P   S+TA + + V D NDN P FS   Y   V+
Sbjct: 2163 VLLHSLDREASASHELVILASDSGCPP--LSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220

Query: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
            E    G+ +  V+A+DRD GS+A + Y+I+SGN +G FYL+  TG L ++ PLDYE   +
Sbjct: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK 2280

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
            +TL V+A D  +   S    +V V VLD ND+AP F+ + F   V E++P+   +  + A
Sbjct: 2281 FTLTVQASDAEKKHFS--FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINA 2338

Query: 530  IDADAGDNARLEYRLA-------GVGHDFP-FTINNGTGWISVAAELDREEVDFYSFGVE 581
            +D DAG    L Y +        G+ +D   F I+  TG I     LD E  + Y   V+
Sbjct: 2339 LDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQ 2398

Query: 582  ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA-- 639
            A+D G    TAS  V V +  +++  P FTQ +Y   L E       +  V A D DA  
Sbjct: 2399 AKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGI 2456

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPL-------DYKLERQYVLAVTASDGTR 692
              VI Y +  G +   FS+   +G   +  ALPL       +  LE + ++A +    ++
Sbjct: 2457 DGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMK-IIAHSPKSDSK 2513

Query: 693  QDTAQIVVNVTDANTHRP--VFQSS 715
              +  + VNV+ ++   P  VF SS
Sbjct: 2514 FASCTVFVNVSFSSEGTPLAVFASS 2538



 Score =  201 bits (512), Expect = 7e-51
 Identities = 224/881 (25%), Positives = 360/881 (40%), Gaps = 91/881 (10%)

Query: 311  VRATDGDAPPNANILYRLLEG--SGGSPSEVFEIDPRSGVIRTRGPVDRE-EVESYQLTV 367
            V A+D D+     I Y L +G  S  +P + F IDP  G I     +DRE +  +Y L V
Sbjct: 79   VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 368  EASDQGRD--------PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            EA D             G  S  A V + +ED NDN P F+   YV  + ++  PG  ++
Sbjct: 138  EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197

Query: 420  RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYETTKEYTLRVR 475
             V A+D+D G    V Y ++ GN    F +D+ TG     ++++S +++   KE    + 
Sbjct: 198  NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEV---MN 254

Query: 476  AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
            + +   P L +      V+  +         S  +         L YL +  +A  AD  
Sbjct: 255  SLEMFLPLLRHFK---KVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE 311

Query: 536  DNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS 595
              AR    LA +          G G I +   L   E    S  V A+D G      +A 
Sbjct: 312  AAARYVANLAKI---------LGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD 362

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDR-DAHSVITYQITSGNTRN 654
            V++ +         F +P+YT  + ED    + + TV A +  ++   I Y+I+SG+   
Sbjct: 363  VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG 422

Query: 655  RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVT--DANTHRPVF 712
            +FSI  + G   +    PLD++ +   VL V A  G+    +   VN+T  D N + P F
Sbjct: 423  KFSIHPRLG--TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480

Query: 713  QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FRIDADTGAVTTQA 771
              +   + +++  P GT + L  A D D+G N  I Y +    P  F ID   G +    
Sbjct: 481  LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540

Query: 772  ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS--YQGSVYEDVP 829
             L   +Q   TL + A D G+  ++    L +++ +  +++P +  +   YQ  V E + 
Sbjct: 541  SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLS 599

Query: 830  PFTSVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYV 888
            P T +LQ  A           + Y+ +   D    F +   +G +   R+ D E+   Y 
Sbjct: 600  PMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS-AMFGIRPYTGWIYLRRQFDYESTQTYN 658

Query: 889  LRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
             R +A + +          V V V D NDN P F  D   + VEE+      + ++TA D
Sbjct: 659  FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718

Query: 948  PDEGTNAQIMYQIVE--------------GNIPEVFQLD--------------------- 972
             D G N Q++Y ++               G I  +   D                     
Sbjct: 719  MDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV 778

Query: 973  -------IFSGELTALVDLDYEDRPEY---VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
                   +  GEL   V LD E R  +   VLV    S P  +   V+V + D NDN P 
Sbjct: 779  LKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838

Query: 1023 LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTG 1080
                      +V           +  V A DPD  ++  +TYS    +      ++A+ G
Sbjct: 839  FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG 898

Query: 1081 ELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
            E++ +  L  +      MSV+ +D GV  +  Q  + + +I
Sbjct: 899  EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI 939



 Score =  194 bits (492), Expect = 1e-48
 Identities = 231/1001 (23%), Positives = 396/1001 (39%), Gaps = 102/1001 (10%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P +Y  ++ +    GT + ++ A D D G  G + Y    L     +  F++D  T
Sbjct: 175  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY---ELIPGNVSSLFTIDSTT 231

Query: 239  GAVT-TAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE-QQEYKE 296
            G  +   E L     S     + + +  +P    L     +  D    +  FE  + +  
Sbjct: 232  GLYSPEVEILSAVNFSADKEVMNSLEMFLP---LLRHFKKVERDEEAAEKKFEASRGWFM 288

Query: 297  SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
              +    + Y  +   A   D    A  +  L +  G             G+I    P+ 
Sbjct: 289  RFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILG------------EGIIYLTLPLS 336

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
              E  +  L V A D G         A V + +        +F   +Y   V EDV   +
Sbjct: 337  HLESTTLSLMVSAQDGGGLTA--VINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 394

Query: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
            P+  V A +    S+  + Y I SG+  G+F +  + G +    PLD+ET     L V+A
Sbjct: 395  PIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA 453

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
            Q G  P  S+    V + V+D+NDN P F+ T  +  + ++ P G  +   +A D D+G 
Sbjct: 454  QLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511

Query: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
            N  + Y +A       F I+   G + +   L   E    +  + A D G     A+  V
Sbjct: 512  NGLIRYSIAS-PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAALLV 569

Query: 597  SVTVLDVNDNNP--TFTQPEYTVRLNEDAAVGTSVVTVSA---VDRDAHSVITYQITSGN 651
               V++  +++P  TF    Y V ++E  +  T ++   A     + A S + Y +    
Sbjct: 570  LTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSV 629

Query: 652  TRNRFSITSQSGGGLVSLALPLDYKLERQY---VLAVTASDGTRQD-TAQIVVNVTDANT 707
                F I   +  G + L    DY+  + Y   V A    DG  Q+ +  ++V V D N 
Sbjct: 630  DSAMFGIRPYT--GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 687

Query: 708  HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGA- 766
            + P F      + V E       +  I+A D D+G+N ++ YF+      F+++ +TG  
Sbjct: 688  NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPA 747

Query: 767  ----VTTQAE---------------------------------------LDYEDQVSYTL 783
                V T A+                                       LD E +  + +
Sbjct: 748  GTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEM 807

Query: 784  AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLR----DSYQGSVYEDVPPFTSVLQISA 839
             +   D G P ++ T  + + V D+NDN P F +          V E  P    V  + A
Sbjct: 808  TVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFA 867

Query: 840  TDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP 899
             D D G N  V Y+    D  D  F +++ +G +RT   L  +    Y +   A D+G+P
Sbjct: 868  KDPDEGNNAEVTYSVSSEDSSD-HFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP 926

Query: 900  PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDP-DEGTNAQIMY 958
            P +    V + V+ ++    +  Q+   + + EN      ++ + ++D   +  N ++ +
Sbjct: 927  PLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHF 986

Query: 959  QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT----SAPLVSRATVHVRLL 1014
             IV  +    F++D  +G+L    +LDYE    Y+  +  T    +  L S   + + + 
Sbjct: 987  SIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVE 1046

Query: 1015 DRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRV-PAHDPD---ISDSLTYSFERGNE- 1069
            D+ND+ P   +  I     V +   + P G +  V  A D D   ++  + Y  E  N  
Sbjct: 1047 DQNDHSPSFQDELI-----VISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPG 1101

Query: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVT 1110
             +  L++ S G L     LD       I++V  SD   +VT
Sbjct: 1102 TNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVT 1142



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 46/165 (27%), Positives = 77/165 (46%), Gaps = 18/165 (10%)

Query: 836 QISATDRDSGLNGRVFYTFQGGD---DGDGDFIVESTSGIVRTLRRLDRE-NVAQYVLRA 891
           +++A+D DSGL G + Y+   G    +    F ++   G +   + +DRE + A Y L  
Sbjct: 78  EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 892 YAVD------------KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
            A D            KG   A+    V V + DVNDN PVF    +   + + +  G  
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQA--FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195

Query: 940 VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDL 984
           +  V ATD D G    + Y+++ GN+  +F +D  +G  +  V++
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240


>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score =  333 bits (855), Expect = 1e-90
 Identities = 307/1010 (30%), Positives = 446/1010 (44%), Gaps = 107/1010 (10%)

Query: 171  RKRNVNT-APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFD---S 226
            R  +VN  +P+F   S Q  V E  P GT      A DPD G      YT+    D    
Sbjct: 156  RVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKD 215

Query: 227  RSNQFFSLDPVT----------GAVTTAE--------ELDRETKSTHVFRVTAQDHGMPR 268
             +  FF L   T          G+ +  E         LDRE  + H  ++ A D G PR
Sbjct: 216  PAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPR 275

Query: 269  RSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRL 328
            R+ L ++ + V D ND+ PVFEQ EY+ ++RE+ + G EV  VRATD D  PN  + Y +
Sbjct: 276  RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV 335

Query: 329  L------EGSGG---SPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR 379
                    GSGG     +  F ++  SGV+R   P+DRE    +QL VEA D G +  P 
Sbjct: 336  RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE--PE 393

Query: 380  STTAAVFLSVEDDNDNAPQ----FSEKRYVVQVREDVTPGAPVLRVTASDRD----KGSN 431
              T  V ++V D NDN P     F  +  V +V E   PG  V RV+ SD D    K   
Sbjct: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453

Query: 432  AVVHYSIMSGNARGQFYLDAQTG-------------ALDVVSPLDYETTKEYTLRVRAQD 478
            A     +  G+      L+   G              L V  PLD E+   Y L + A D
Sbjct: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513

Query: 479  GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD--AGD 536
             G PPLS    L+ ++V D+ND  P+F    ++A+V E+   G +V+ V A DAD    D
Sbjct: 514  AGSPPLSTEETLL-LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSD 572

Query: 537  NARLEYRLAGVGHDF-----------------PFTINNGTGWISVAAELDREEVDFYSFG 579
            +A L Y +  +                      F I++ +G IS    LDRE  +     
Sbjct: 573  HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A+D G P L+A+  VS+TV DVNDN P F +  Y   + E A VG   + V+A D D+
Sbjct: 633  VVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS 692

Query: 640  --HSVITYQITSG----NTRNRFSITSQSGGGLVSLALPLDYKLERQ---YVLAVTASDG 690
              +  I Y +  G         F I    G     + +  D   ER    Y L V A DG
Sbjct: 693  GLYGFIEYSLYDGFLSYEAPQAFRIDPHDG----QICVSQDIDRERDPATYDLLVEAKDG 748

Query: 691  TRQDTAQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
                    V V++ D N + PVF  S Y  +++++   GT ++ + ATD+D+G    + Y
Sbjct: 749  GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808

Query: 750  FMEDSIP-----QFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL 804
               + IP      F ID+ TG +     L + +  + +L ++A+D G         + I 
Sbjct: 809  ---ELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 865

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
            +        +F R  Y   VYEDVP  + +  + A +     +  +FY    GD G G F
Sbjct: 866  IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG-GKF 923

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQD 924
             +    G +RT + LD E     VL   A   G  PA +  EV +TV+DVNDN P F + 
Sbjct: 924  SIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRT 982

Query: 925  EFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDL 984
              ++ + + +P G A+    A D D G N  I Y I     P VF +D   G L     L
Sbjct: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSL 1041

Query: 985  DYEDRPEYVLVIQATSAPLVSRATVHVR--LLDRNDNPPVLGNFEILFNNYVTNRSSSFP 1042
               ++ E  L ++A    +  +A + V   ++++ ++ P    FE L      + S S P
Sbjct: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP-SWTFEHLVYQVEVSESLS-P 1099

Query: 1043 GGAIGRVPAH---DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
               + +  AH       +  L YS E   + ++  +   TG + L R  D
Sbjct: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149



 Score =  317 bits (811), Expect = 1e-85
 Identities = 291/1001 (29%), Positives = 446/1001 (44%), Gaps = 101/1001 (10%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM------------DALFDS 226
            P F+   Y+A V E+   G  V  +RA D D G  G + Y++             AL D+
Sbjct: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353

Query: 227  RSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHD 286
                +F+++ ++G V     LDRE ++ H   V A+D G     A   ++I V D ND+ 
Sbjct: 354  A---YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410

Query: 287  PVFEQQEYKES----LRENLEVGYEVLTVRATDGDAP---------------PNANILYR 327
            P        E     + E    G  V  V  +D D                  + +I   
Sbjct: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470

Query: 328  LLEGSG------GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRST 381
            L  G G      G P  VF        +   GP+DRE  + Y+L + A+D G  P   ST
Sbjct: 471  LEGGEGDFALLPGGPPGVF-------FLCVEGPLDRESRDLYELLLVATDAGSPP--LST 521

Query: 382  TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSN--AVVHYSIM 439
               + L V D ND  P FS++ Y   V E   PG  V+ V+ASD D+  +  A + Y+++
Sbjct: 522  EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581

Query: 440  SGNAR-----------------GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
              +A                    F +D+++GA+  +  LD E  +   L+V AQD G P
Sbjct: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP 641

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
            PLS  + LV++ V D+NDN PIF    + AT+ E  P+G+  L V A DAD+G    +EY
Sbjct: 642  PLS-ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700

Query: 543  RLAG--VGHDFP--FTINNGTGWISVAAELDRE-EVDFYSFGVEARDHGTPALTASASVS 597
             L    + ++ P  F I+   G I V+ ++DRE +   Y   VEA+D G   L+A A V 
Sbjct: 701  SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVR 758

Query: 598  VTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNR 655
            V + DVNDN+P F    Y   ++++   GT ++ V A D+D+  +  + Y++  GN  + 
Sbjct: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818

Query: 656  FSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVF 712
            F+I S +G  ++ L LPL +       L V+A DG   T    A + +++         F
Sbjct: 819  FTIDSTTG--IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876

Query: 713  QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDADTGAVTTQ 770
            +   YT  V ED P  + +  + A  E    +  I Y +   D   +F I    G + T+
Sbjct: 877  ERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTR 935

Query: 771  AELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP 830
              LD+E Q    L + A+    P  S T  + I V DVNDN P FLR S +  + +  PP
Sbjct: 936  KPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPP 994

Query: 831  FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLR 890
             T++    A DRDSG NG + Y+      G   F ++   G++     L      +  L 
Sbjct: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGV--FAIDRALGVLFLNGSLGAGEQRELTLT 1052

Query: 891  AYAVDKGMPPARTPMEVTVTVLDVNDNPP-VFEQDEFDVFVEEN-SPIGLAVARVTATDP 948
              A D+G+ P    + +TV +     +P   FE   + V V E+ SP+   +        
Sbjct: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAP-----L 1003
             +   + + Y +       +F +  ++G +      DYE    Y   + A          
Sbjct: 1113 PQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQN 1172

Query: 1004 VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYS 1063
            VS  TV VR+ D NDN P   + ++LF   +    S  P G IG++ A D D   +    
Sbjct: 1173 VS-TTVIVRVWDENDNSPTFLH-DVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227

Query: 1064 FERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            +   ++     +N +TGEL    ALD        M+VLV+D
Sbjct: 1228 YFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268



 Score =  313 bits (803), Expect = 1e-84
 Identities = 317/1095 (28%), Positives = 473/1095 (43%), Gaps = 135/1095 (12%)

Query: 149  KLAQAPGLRAGERSPEESLGGRRKRNV-----------NTAPQFQPPSYQATVPENQPAG 197
            KL   PG R        S G R +R++            +    Q  +   +V E  P  
Sbjct: 21   KLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPD 80

Query: 198  TPVASLRAIDP----DEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKS 253
            T V  +RA  P     EG    L    D   DS     F + P TG + TA  LDRE + 
Sbjct: 81   TLVGDIRAGLPAAQQQEGSGFFLSEDSD---DSPLLDDFHVHPDTGIIRTARRLDRERRD 137

Query: 254  THVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRA 313
             + F V A   G     A+  + I V D NDH P F     +  + E    G       A
Sbjct: 138  HYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191

Query: 314  TDGDAPPNANILYRLLEGS------------------GGSPSEVF-----EIDPRSGVIR 350
             D DA   +   Y L++ S                  G  PS +       ++P   V+ 
Sbjct: 192  HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLL 251

Query: 351  TRGPVDREEVESYQLTVEASDQGRDPGPRST-TAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
             R  +DREE  +++L +EA D GR   PR T   +V L V D+NDN P F +  Y   VR
Sbjct: 252  RR--LDREEAAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306

Query: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMS---------GNARGQ---FYLDAQTGALD 457
            ED  PGA V RV A+DRD G N  V YS+ +         G A G    F ++  +G + 
Sbjct: 307  EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366

Query: 458  VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP----IFVSTPFQAT 513
            V  PLD E    + L V A+DGG  P    +  V++ VLD+NDN P    +F++    A 
Sbjct: 367  VWRPLDREAQAWHQLVVEARDGGAEP-EVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425

Query: 514  VLESVPLGYLVLHVQAIDADA----------------GDNARLEYRLAGVGHDFPFTINN 557
            V E    G  V  V   DAD                 GD + +   L G   DF      
Sbjct: 426  VSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS-ISLSLEGGEGDFALLPGG 484

Query: 558  --GTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEY 615
              G  ++ V   LDRE  D Y   + A D G+P L+   ++ + V D+ND  P F+Q  Y
Sbjct: 485  PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544

Query: 616  TVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITS-------GNTRNRFSITSQSG- 663
               ++E AA GT V+ VSA D D     H+ + Y +         G+ +++   T++ G 
Sbjct: 545  KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604

Query: 664  -------GGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVT--DANTHRPVFQ 713
                    G +S    LD +++    L V A D G    +A  +V++T  D N + P+F 
Sbjct: 605  SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-----FMEDSIPQ-FRIDADTGAV 767
               Y   + E  P G   + ++A+D D+G    I Y     F+    PQ FRID   G +
Sbjct: 665  RQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI 724

Query: 768  TTQAELDYE-DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826
                ++D E D  +Y L + A+D G    S   ++ + + DVNDN P F   +Y  S+ +
Sbjct: 725  CVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782

Query: 827  DVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQ 886
            +  P T ++ + ATD+DSG+ G V Y    G +    F ++ST+GI+     L       
Sbjct: 783  ETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGIIYLTLPLSHLESTT 841

Query: 887  YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTAT 946
              L   A D G   A    +VT+ +      P  FE+ ++   V E+ P    +  V A 
Sbjct: 842  LSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR 901

Query: 947  DPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT--SAPLV 1004
            +P   ++  I Y+I  G++   F +    G +     LD+E +P  VL +QA   SAP  
Sbjct: 902  EP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960

Query: 1005 SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTY 1062
            S   V++ ++D NDN P      +  ++ +    ++ PG A+    A D D   +  + Y
Sbjct: 961  SSTEVNITVMDVNDNHPAF----LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRY 1016

Query: 1063 SFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIIT 1121
            S     +  +  ++ + G L L+ +L      E  +++   D GVH    Q AL V  + 
Sbjct: 1017 SI-ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH---PQAALLVLTVV 1072

Query: 1122 DEMLTHSITLRLEDM 1136
             E   HS +   E +
Sbjct: 1073 IEKREHSPSWTFEHL 1087



 Score =  306 bits (785), Expect = 1e-82
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 162  SPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGR--LEYT 219
            S EE+L  R     +  P F    Y+A+V E    GT V  + A D DE  +    L YT
Sbjct: 520  STEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579

Query: 220  MDAL--------------FDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHG 265
            +  L                +     F++D  +GA++T   LDRE +     +V AQD G
Sbjct: 580  VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG 639

Query: 266  MPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANIL 325
             P  SA   ++I V D ND++P+F +Q Y  ++ E+  VG+  L V A+D D+     I 
Sbjct: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699

Query: 326  YRLLEG--SGGSPSEVFEIDPRSGVIRTRGPVDRE-EVESYQLTVEASDQGRDPGPRSTT 382
            Y L +G  S  +P + F IDP  G I     +DRE +  +Y L VEA    +D G  S  
Sbjct: 700  YSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLVEA----KDGGGLSAQ 754

Query: 383  AAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN 442
            A V + +ED NDN P F+   YV  + ++  PG  ++ V A+D+D G    V Y ++ GN
Sbjct: 755  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 814

Query: 443  ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F +D+ TG + +  PL +  +   +L V AQDGG    + ++  VT+ +       
Sbjct: 815  VSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLT-AVINADVTIHIFQTTLAP 873

Query: 503  PIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWI 562
              F    +   V E VP    +  V+A +     +  + YR++       F+I+   G I
Sbjct: 874  AEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTI 932

Query: 563  SVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED 622
                 LD E        V+A+    PA + S  V++TV+DVNDN+P F +    +R+++ 
Sbjct: 933  RTRKPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQT 991

Query: 623  AAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ 680
               GT++    A DRD+  + +I Y I S      F+I    G  ++ L   L    +R+
Sbjct: 992  TPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALG--VLFLNGSLGAGEQRE 1048

Query: 681  YVLAVTASD-GTRQDTAQIVVNVT-DANTHRPVFQSSH--YTVNVNEDRPAGTTVVLISA 736
              L + A D G     A +V+ V  +   H P +   H  Y V V+E     T ++   A
Sbjct: 1049 LTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108

Query: 737  TDEDTGENAR-ITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITA--RDNG 791
                    A  + Y +E S+    F I   TG +  + + DYE   +Y   + A   ++G
Sbjct: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168

Query: 792  IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVF 851
              Q   TT + + V D NDN+P FL D     V E   P   + +I+A D DSG NG++ 
Sbjct: 1169 FLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227

Query: 852  YTFQGGDDGDGDFI-VESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVT 910
            Y        DG F  +   +G +     LDRE+   + +     D+G PP    M V V+
Sbjct: 1228 YFLLS----DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283

Query: 911  VLDVNDNPPVFEQ----DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960
            V D+NDN P F Q     E  V V E  P+ + V  V A DPDEG NA++ Y +
Sbjct: 1284 VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337



 Score =  285 bits (728), Expect = 6e-76
 Identities = 240/809 (29%), Positives = 365/809 (45%), Gaps = 47/809 (5%)

Query: 247  LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
            LDRE++  +   + A D G P  S   TL + V D ND  P+F QQ YK S+ E    G 
Sbjct: 497  LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556

Query: 307  EVLTVRATDGD-----------------APPNANILY-RLLEGSGGSPSEVFEIDPRSGV 348
             V+ V A+D D                 AP N   L  +++  +   PS  F ID  SG 
Sbjct: 557  VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS--FAIDSESGA 614

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
            I T   +DRE  E+ +L V A D G  P   S T  V ++V+D NDN P F  + Y   +
Sbjct: 615  ISTIRTLDREVQEAVELKVVAQDLGEPP--LSATCLVSITVDDVNDNEPIFWRQVYNATI 672

Query: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSG----NARGQFYLDAQTGALDVVSPLDY 464
             E    G   L+VTASD D G    + YS+  G     A   F +D   G + V   +D 
Sbjct: 673  AEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 732

Query: 465  ETTKE-YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523
            E     Y L V A+DGG     +    V V + D+NDN P+F  + +  ++ +    G  
Sbjct: 733  ERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 789

Query: 524  VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
            +++V A D D+G    + Y L        FTI++ TG I +   L   E    S  V A+
Sbjct: 790  IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQ 849

Query: 584  DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDR-DAHSV 642
            D G      +A V++ +         F +P+YT  + ED    + + TV A +  ++   
Sbjct: 850  DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP 909

Query: 643  ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNV 702
            I Y+I+SG+   +FSI  + G   +    PLD++ +   VL V A  G+    +   VN+
Sbjct: 910  IFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNI 967

Query: 703  T--DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FR 759
            T  D N + P F  +   + +++  P GT + L  A D D+G N  I Y +    P  F 
Sbjct: 968  TVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFA 1027

Query: 760  IDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS 819
            ID   G +     L   +Q   TL + A D G+  ++    L +++ +  +++P +  + 
Sbjct: 1028 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEH 1086

Query: 820  --YQGSVYEDVPPFTSVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
              YQ  V E + P T +LQ  A           + Y+ +   D    F +   +G +   
Sbjct: 1087 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS-AMFGIRPYTGWIYLR 1145

Query: 877  RRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
            R+ D E+   Y  R +A + +          V V V D NDN P F  D   + VEE+  
Sbjct: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 1205

Query: 936  IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY--- 992
                + ++TA D D G N Q++Y ++     + F+++  +GEL   V LD E R  +   
Sbjct: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMT 1263

Query: 993  VLVIQATSAPLVSRATVHVRLLDRNDNPP 1021
            VLV    S P  +   V+V + D NDN P
Sbjct: 1264 VLVTDRGSPPRNATMAVYVSVTDINDNRP 1292



 Score =  255 bits (651), Expect = 5e-67
 Identities = 251/953 (26%), Positives = 393/953 (41%), Gaps = 122/953 (12%)

Query: 328  LLEGSGGSPS-EVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVF 386
            L E S  SP  + F + P +G+IRT   +DRE  + Y   V A+  G           V 
Sbjct: 103  LSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLG-------AVVQVE 154

Query: 387  LSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---- 442
            + V D ND++P+F      + V E   PG       A D D G  +   Y+++  +    
Sbjct: 155  IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214

Query: 443  --ARGQFYLDAQT----------GALDVVSPLDY--------ETTKEYTLRVRAQDGGRP 482
              A   F L  +T          G+   + PLD         E    + L++ A DGGRP
Sbjct: 215  DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274

Query: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
              + +   V ++VLD NDN P+F    ++A V E    G  V  V+A D D G N  + Y
Sbjct: 275  RRTGLLS-VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333

Query: 543  RL------------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
             +              +G    F +   +G + V   LDRE   ++   VEARD G    
Sbjct: 334  SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393

Query: 591  TASASVSVTVLDVNDNNPT----FTQPEYTVRLNEDAAVGTSVVTVSAVDRDA----HSV 642
             A+  VS+ VLDVNDN P     F       R++E A  G  V  VS  D D        
Sbjct: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453

Query: 643  ITYQITSGNTRNRFSITSQSGGGLVSLAL-------------PLDYKLERQYVLAVTASD 689
             T ++  G      S++ + G G  +L               PLD +    Y L + A+D
Sbjct: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513

Query: 690  GTRQDTAQ---IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--EN 744
                  +    +++ V D N   P+F   HY  +V+E    GT V+ +SA+D D    ++
Sbjct: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573

Query: 745  ARITYFM-------------------EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAI 785
            A + Y +                    +  P F ID+++GA++T   LD E Q +  L +
Sbjct: 574  AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633

Query: 786  TARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSG 845
             A+D G P  S T  + I V+DVNDN P F R  Y  ++ E  P     LQ++A+D DSG
Sbjct: 634  VAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG 693

Query: 846  LNGRVFYTFQGG---DDGDGDFIVESTSGIVRTLRRLDRE-NVAQYVLRAYAVDKGMPPA 901
            L G + Y+   G    +    F ++   G +   + +DRE + A Y L   A D G   A
Sbjct: 694  LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSA 753

Query: 902  RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961
            +    V V + DVNDN PVF    +   + + +  G  +  V ATD D G    + Y+++
Sbjct: 754  QA--FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 811

Query: 962  EGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRND 1018
             GN+  +F +D  +G +   + L + +     L++ A        V  A V + +     
Sbjct: 812  PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL 871

Query: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDP-DISDSLTYSFERGNELSLVLLNA 1077
             P      +  F  Y      S     IG V A +P + S+ + Y    G+      ++ 
Sbjct: 872  APAEFERPKYTFLVYEDVPEDS----PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927

Query: 1078 STGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMS 1137
              G ++  + LD+      +++V    G     +   + +T++ D    H   LR  D  
Sbjct: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVM-DVNDNHPAFLRTSD-- 984

Query: 1138 PERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQP 1190
                           +  +  TPP   +      D D+    ++  S++  QP
Sbjct: 985  --------------EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023



 Score =  186 bits (473), Expect = 2e-46
 Identities = 168/592 (28%), Positives = 258/592 (43%), Gaps = 32/592 (5%)

Query: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
            P F P +Y  ++ +    GT + ++ A D D G  G + Y    L     +  F++D  T
Sbjct: 769  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTT 825

Query: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
            G +     L     +T    V+AQD G       A +TI +  T      FE+ +Y   +
Sbjct: 826  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885

Query: 299  RENLEVGYEVLTVRATDGDAPPNAN--ILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
             E++     + TV+A +   P N++  I YR+  G  G     F I PR G IRTR P+D
Sbjct: 886  YEDVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTRKPLD 939

Query: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
             E      LTV+A        P  ++  V ++V D NDN P F      +++ +   PG 
Sbjct: 940  HETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996

Query: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
             +    A DRD G N ++ YSI S    G F +D   G L +   L     +E TL +RA
Sbjct: 997  ALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 1055

Query: 477  QDGGRPPLSNVSGLVTVQVLDINDNAP--IFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
            +D G  P + +  LV   V++  +++P   F    +Q  V ES+     +L  QA     
Sbjct: 1056 EDQGVHPQAAL--LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113

Query: 535  GDNAR-LEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL-TA 592
               A  L Y L        F I   TGWI +  + D E    Y+F V A       L   
Sbjct: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173

Query: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS---VITYQITS 649
            S +V V V D NDN+PTF      +++ E       +  ++A+D D+     ++ + ++ 
Sbjct: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233

Query: 650  GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANTH 708
            G     F +   +G  +  +AL  +++   +  + VT      R  T  + V+VTD N +
Sbjct: 1234 GKF---FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290

Query: 709  RPVFQS----SHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP 756
            RP F          V V E +P    V  + A D D G NA +TY +  + P
Sbjct: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  311 bits (798), Expect = 5e-84
 Identities = 221/695 (31%), Positives = 349/695 (50%), Gaps = 46/695 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 220

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 395

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 396 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 456 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 514

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             ++ V A DAD+G NA + Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 515 IQLMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFT 571

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 572 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 632 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 687

Query: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPA---GTTVVLISATDEDTGENARITYFM 751
           +A++ +NV D N ++PVF    Y  +     P+   GT V  + A D DTG NA + Y +
Sbjct: 688 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 747

Query: 752 --EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVNDV 808
              ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+ 
Sbjct: 748 VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNES 807

Query: 809 NDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
             NA   + +  + S+   V P T +  +S+   D
Sbjct: 808 VTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 841



 Score =  288 bits (738), Expect = 4e-77
 Identities = 216/705 (30%), Positives = 337/705 (47%), Gaps = 43/705 (6%)

Query: 316 GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
           GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 102 GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 147

Query: 376 PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
           P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207

Query: 436 YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
           Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 266

Query: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
           + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 267 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326

Query: 551 FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 384

Query: 608 PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
           P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444

Query: 661 QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
            S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 445 -SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
           TV++ E+   G  ++ +SATD D+G NA I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 777 DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
            +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y+  V E++P   +V  
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623

Query: 837 ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
           I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 624 ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680

Query: 897 GMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI---GLAVARVTATDPDEGTN 953
           G     +  +VT+ V+DVNDN PVF    ++   E   P    G  V +V A D D G N
Sbjct: 681 GRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMN 740

Query: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
           A++ Y IV GN  ++F +D  +G +T +   D  D   + ++++A
Sbjct: 741 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 785



 Score =  283 bits (723), Expect = 2e-75
 Identities = 223/758 (29%), Positives = 352/758 (46%), Gaps = 46/758 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 66  IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 123

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 124 DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 183

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 244 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 362 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 418

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 419 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 475

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  ++ VSA D D+  ++ I Y
Sbjct: 476 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY 535

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 536 -LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 593 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 652

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+   Y  
Sbjct: 653 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 712

Query: 823 S---VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
           S   V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + + 
Sbjct: 713 SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEKC 771

Query: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
           D  ++  + +   A D G P +     V +  L VN++
Sbjct: 772 DVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 807



 Score =  281 bits (718), Expect = 9e-75
 Identities = 202/629 (32%), Positives = 310/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 154  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 214  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 274  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 334  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 392  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 450

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
               A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 451  ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   ++++SATD DSG N  + Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 511  NSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKY 568

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E+  +V EN P    V  +T TD
Sbjct: 569  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 628

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 629  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 686

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNNYVTN--RSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +   NY       S+ PG  + +V A D D  ++  +
Sbjct: 687  SSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 743

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 744  RYSIVGGNTRDLFAIDQETGNITLMEKCD 772



 Score =  216 bits (550), Expect = 3e-55
 Identities = 179/614 (29%), Positives = 290/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 93   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 149

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 150  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 210  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 269

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 270  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 330  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 386

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 387  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 445

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++     LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 446  NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 505

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+ATD D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 506  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK 564

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  F  YV         G 
Sbjct: 565  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKF--YVPENLPRH--GT 620

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 621  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 681  -GRVSRSSSAKVTI 693


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  311 bits (798), Expect = 5e-84
 Identities = 221/695 (31%), Positives = 349/695 (50%), Gaps = 46/695 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 220

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 395

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 396 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 456 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 514

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             ++ V A DAD+G NA + Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 515 IQLMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFT 571

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 572 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 632 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 687

Query: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPA---GTTVVLISATDEDTGENARITYFM 751
           +A++ +NV D N ++PVF    Y  +     P+   GT V  + A D DTG NA + Y +
Sbjct: 688 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 747

Query: 752 --EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVNDV 808
              ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+ 
Sbjct: 748 VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNES 807

Query: 809 NDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
             NA   + +  + S+   V P T +  +S+   D
Sbjct: 808 VTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 841



 Score =  288 bits (738), Expect = 4e-77
 Identities = 216/705 (30%), Positives = 337/705 (47%), Gaps = 43/705 (6%)

Query: 316 GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
           GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 102 GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 147

Query: 376 PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
           P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207

Query: 436 YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
           Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 266

Query: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
           + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 267 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326

Query: 551 FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 384

Query: 608 PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
           P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444

Query: 661 QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
            S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 445 -SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
           TV++ E+   G  ++ +SATD D+G NA I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 777 DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
            +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y+  V E++P   +V  
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623

Query: 837 ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
           I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 624 ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680

Query: 897 GMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI---GLAVARVTATDPDEGTN 953
           G     +  +VT+ V+DVNDN PVF    ++   E   P    G  V +V A D D G N
Sbjct: 681 GRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMN 740

Query: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
           A++ Y IV GN  ++F +D  +G +T +   D  D   + ++++A
Sbjct: 741 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 785



 Score =  283 bits (723), Expect = 2e-75
 Identities = 223/758 (29%), Positives = 352/758 (46%), Gaps = 46/758 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 66  IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 123

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 124 DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 183

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 244 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 362 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 418

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 419 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 475

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  ++ VSA D D+  ++ I Y
Sbjct: 476 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY 535

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 536 -LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 593 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 652

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+   Y  
Sbjct: 653 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 712

Query: 823 S---VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
           S   V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + + 
Sbjct: 713 SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEKC 771

Query: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
           D  ++  + +   A D G P +     V +  L VN++
Sbjct: 772 DVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 807



 Score =  281 bits (718), Expect = 9e-75
 Identities = 202/629 (32%), Positives = 310/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 154  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 214  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 274  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 334  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 392  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 450

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
               A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 451  ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   ++++SATD DSG N  + Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 511  NSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKY 568

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E+  +V EN P    V  +T TD
Sbjct: 569  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 628

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 629  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 686

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNNYVTN--RSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +   NY       S+ PG  + +V A D D  ++  +
Sbjct: 687  SSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 743

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 744  RYSIVGGNTRDLFAIDQETGNITLMEKCD 772



 Score =  216 bits (550), Expect = 3e-55
 Identities = 179/614 (29%), Positives = 290/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 93   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 149

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 150  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 210  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 269

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 270  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 330  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 386

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 387  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 445

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++     LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 446  NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 505

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+ATD D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 506  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK 564

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  F  YV         G 
Sbjct: 565  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKF--YVPENLPRH--GT 620

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 621  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 681  -GRVSRSSSAKVTI 693


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  311 bits (798), Expect = 5e-84
 Identities = 221/695 (31%), Positives = 349/695 (50%), Gaps = 46/695 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 155 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 209

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 269

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 329

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 330 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 384

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 385 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 444

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 445 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 503

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             ++ V A DAD+G NA + Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 504 IQLMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFT 560

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 561 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 621 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 676

Query: 695 TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPA---GTTVVLISATDEDTGENARITYFM 751
           +A++ +NV D N ++PVF    Y  +     P+   GT V  + A D DTG NA + Y +
Sbjct: 677 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 736

Query: 752 --EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVNDV 808
              ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+ 
Sbjct: 737 VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNES 796

Query: 809 NDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
             NA   + +  + S+   V P T +  +S+   D
Sbjct: 797 VTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 830



 Score =  288 bits (738), Expect = 4e-77
 Identities = 216/705 (30%), Positives = 337/705 (47%), Gaps = 43/705 (6%)

Query: 316 GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
           GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 91  GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 136

Query: 376 PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
           P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 137 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196

Query: 436 YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
           Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 197 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 255

Query: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
           + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 256 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 315

Query: 551 FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 316 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 373

Query: 608 PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
           P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 433

Query: 661 QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
            S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 434 -SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492

Query: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
           TV++ E+   G  ++ +SATD D+G NA I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552

Query: 777 DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
            +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y+  V E++P   +V  
Sbjct: 553 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 612

Query: 837 ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
           I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 613 ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 669

Query: 897 GMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI---GLAVARVTATDPDEGTN 953
           G     +  +VT+ V+DVNDN PVF    ++   E   P    G  V +V A D D G N
Sbjct: 670 GRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMN 729

Query: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
           A++ Y IV GN  ++F +D  +G +T +   D  D   + ++++A
Sbjct: 730 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 774



 Score =  283 bits (723), Expect = 2e-75
 Identities = 223/758 (29%), Positives = 352/758 (46%), Gaps = 46/758 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 55  IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 112

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 113 DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 172

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 173 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 233 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 290

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 291 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 350

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 351 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 407

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 408 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 464

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  ++ VSA D D+  ++ I Y
Sbjct: 465 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY 524

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 525 -LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 581

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 582 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 641

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+   Y  
Sbjct: 642 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 701

Query: 823 S---VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
           S   V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + + 
Sbjct: 702 SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEKC 760

Query: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
           D  ++  + +   A D G P +     V +  L VN++
Sbjct: 761 DVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 796



 Score =  281 bits (718), Expect = 9e-75
 Identities = 202/629 (32%), Positives = 310/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 143  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 202

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 203  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 262

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 263  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 322

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 323  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 380

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 381  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 439

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
               A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 440  ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   ++++SATD DSG N  + Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 500  NSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKY 557

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E+  +V EN P    V  +T TD
Sbjct: 558  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 617

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 618  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 675

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNNYVTN--RSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +   NY       S+ PG  + +V A D D  ++  +
Sbjct: 676  SSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 732

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 733  RYSIVGGNTRDLFAIDQETGNITLMEKCD 761



 Score =  216 bits (550), Expect = 3e-55
 Identities = 179/614 (29%), Positives = 290/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 82   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 138

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 139  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 198

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 199  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 258

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 259  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 318

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 319  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 375

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 376  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 434

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++     LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 435  NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 494

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+ATD D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 495  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK 553

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  F  YV         G 
Sbjct: 554  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKF--YVPENLPRH--GT 609

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 610  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 669

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 670  -GRVSRSSSAKVTI 682


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  311 bits (796), Expect = 8e-84
 Identities = 222/742 (29%), Positives = 347/742 (46%), Gaps = 65/742 (8%)

Query: 320  PNANILYRLLEGSGGSPSEVFEIDPRSG-VIRTRGPVDREEVESYQ-----------LTV 367
            P+   LY+L  G+         +D ++G +  T   +DRE +   Q             V
Sbjct: 84   PDVGHLYKLEVGA-----PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEV 138

Query: 368  EASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRD 427
              +D  ++  PR     +   V+D NDN P F+     + + E+   G+      ASDRD
Sbjct: 139  SITDLVQNGSPRLLEGQI--EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 428  KGSNAVVHYSIMSGNARGQFY-------LDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
             G N V  Y + +G    + +        + +   L V+  LD E    Y L ++ QDGG
Sbjct: 197  AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256

Query: 481  RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
             PP ++ S L+ V VLD NDNAP F    ++A + E+ P+G+ V+ V+A D+D G NA +
Sbjct: 257  SPPRAS-SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315

Query: 541  EYRLAGVGHDFP------FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
            EY      H  P        ++  TG I+V   +DRE++    F V A+D GT   +A A
Sbjct: 316  EYTF----HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARA 371

Query: 595  SVSVTVLDVNDNNPTF--------TQPEYTVRLNEDAAVGTSVVTVSAVDRD-AHSVITY 645
             V VTV D+NDN PT         T  +    ++ED A  T+V  V   DRD   +    
Sbjct: 372  QVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT 431

Query: 646  QITSGNTRNRFSITSQSGGG-----LVSLALPLDYKLERQYVLAVTASDGTR---QDTAQ 697
             + +G+   +    S++G        +    PLDY+  + Y + + A D        T  
Sbjct: 432  CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNS 491

Query: 698  IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
            + V V D N + PVF  S   V   E+   G  +  I+A+D D+G NA + Y +E     
Sbjct: 492  LKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAA 551

Query: 758  ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQ 814
               F I  +TG +  +  LD E + SY L + A D G P    T  + + V D NDN P+
Sbjct: 552  KGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPK 611

Query: 815  FLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVR 874
            F+   Y  SV E++P  + V  ++  D D G N +V  +    +  +GDF++++ +G + 
Sbjct: 612  FMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTIL 668

Query: 875  TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVF--EQDEFDVFVEE 932
            +    DRE  + Y  +  AVD G+PP    + VT+ VLD NDN P      +     +  
Sbjct: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728

Query: 933  NSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY 992
             + +G  V++V A D D G NA+++Y I  GN   +FQ+   SG +T   +++      +
Sbjct: 729  QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788

Query: 993  VLVIQAT---SAPLVSRATVHV 1011
             LV++ +     P    A VH+
Sbjct: 789  RLVVKVSDRGKPPRYGTALVHL 810



 Score =  298 bits (763), Expect = 5e-80
 Identities = 213/670 (31%), Positives = 323/670 (48%), Gaps = 45/670 (6%)

Query: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
           N NT P F  P     +PEN   G+      A D D G  G   Y + A     + + F 
Sbjct: 162 NDNT-PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA--GPEAQELFG 218

Query: 234 LDPVTGA------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP 287
           L            +     LDRE   ++   +  QD G P R++ A L + V DTND+ P
Sbjct: 219 LQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAP 278

Query: 288 VFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
            FE+  Y+  L EN  +G+ V+ V+A D D   NA I Y   + +      +  +D  +G
Sbjct: 279 KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNTG 337

Query: 348 VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQF-------- 399
           +I  +GPVDRE++ + + +V A D+G +  P+S  A V ++V+D NDNAP          
Sbjct: 338 LITVQGPVDREDLSTLRFSVLAKDRGTN--PKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395

Query: 400 SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA---- 455
           + +  +  + EDV     V  V  SDRD+G NA V   +++G+   Q    ++TG+    
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQLRQASETGSDSKK 454

Query: 456 ---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
              L   +PLDYE  K+YT+ + A D G PPLS+ + L  VQV+D+NDNAP+F  +  + 
Sbjct: 455 KYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDNAPVFTQSVTEV 513

Query: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRL----AGVGHDFPFTINNGTGWISVAAEL 568
              E+   G ++  + A DAD+G NA L Y L    A  G    FTI+  TG I V   L
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG---LFTISPETGEIQVKTSL 570

Query: 569 DREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTS 628
           DRE+ + Y   V A D G+P+L  +A+V V VLD NDN+P F    Y   + E+    + 
Sbjct: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630

Query: 629 VVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
           V  V+ +D D       Q++       F I  Q+G G +  +L  D + +  Y   + A 
Sbjct: 631 VGMVTVIDGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAV 688

Query: 689 DG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVN--VNEDRPAGTTVVLISATDEDTGE 743
           DG    R     + +NV D N + P   +   T +  +      G TV  ++A D D+G 
Sbjct: 689 DGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGV 748

Query: 744 NARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
           NA + Y +    P   F+I + +GA+T + E++      + L +   D G P +  T  +
Sbjct: 749 NAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808

Query: 802 EILVNDVNDN 811
            + VN+   N
Sbjct: 809 HLYVNETLAN 818



 Score =  276 bits (707), Expect = 2e-73
 Identities = 235/763 (30%), Positives = 352/763 (46%), Gaps = 77/763 (10%)

Query: 190 VPENQPAGTPVASLRAID--PDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAE-E 246
           VPE QP  T + SL A    PD G   +LE             +  +D  TG + T E  
Sbjct: 64  VPEEQPPNTLIGSLAADYGFPDVGHLYKLEV---------GAPYLRVDGKTGDIFTTETS 114

Query: 247 LDRE-----------TKSTHVFRVTAQD---HGMPRRSALATLTILVTDTNDHDPVFEQQ 292
           +DRE                 F V+  D   +G PR   L    I V D ND+ P F   
Sbjct: 115 IDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR---LLEGQIEVQDINDNTPNFASP 171

Query: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI------DPRS 346
               ++ EN  +G       A+D DA PN    Y L   +G    E+F +      + + 
Sbjct: 172 VITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL--QAGPEAQELFGLQVAEDQEEKQ 229

Query: 347 GVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVV 406
             +   G +DRE  +SY LT++  D G    PR+++A + ++V D NDNAP+F    Y  
Sbjct: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSP--PRASSALLRVTVLDTNDNAPKFERPSYEA 287

Query: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN--ARGQFYLDAQTGALDVVSPLDY 464
           ++ E+   G  V++V A+D D+G+NA + Y+        R    LD  TG + V  P+D 
Sbjct: 288 ELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDR 347

Query: 465 ETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP--------IFVSTPFQATVLE 516
           E        V A+D G  P S     V V V D+NDNAP        +       A + E
Sbjct: 348 EDLSTLRFSVLAKDRGTNPKS-ARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406

Query: 517 SVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TG-------WISVAAE 567
            V     V  VQ  D D G+NA +   +AG   D PF +     TG       ++     
Sbjct: 407 DVAEETAVALVQVSDRDEGENAAVTCVVAG---DVPFQLRQASETGSDSKKKYFLQTTTP 463

Query: 568 LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGT 627
           LD E+V  Y+  + A D G P L+++ S+ V V+DVNDN P FTQ    V   E+   G 
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523

Query: 628 SVVTVSAVDRD--AHSVITYQI-TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
            +  ++A D D  +++ + Y +      +  F+I+ ++G   + +   LD +    Y L 
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE--IQVKTSLDREQRESYELK 581

Query: 685 VTASD---GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT 741
           V A+D    + Q TA ++VNV D N + P F  S Y  +V E+ PA + V +++  D D 
Sbjct: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDK 641

Query: 742 GENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
           GENA++   +E     F I   TG + +    D E Q +YT  + A D G+P +S    +
Sbjct: 642 GENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGV 701

Query: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFT----SVLQISATDRDSGLNGRVFYTFQGG 857
            I V D NDNAP     S   + ++ + P T    +V Q++A D DSG+N  + Y+  GG
Sbjct: 702 TINVLDENDNAPYITAPS--NTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759

Query: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900
           +   G F + S SG +   + ++R +   + L     D+G PP
Sbjct: 760 NP-YGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPP 801



 Score =  262 bits (669), Expect = 4e-69
 Identities = 199/645 (30%), Positives = 298/645 (46%), Gaps = 37/645 (5%)

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-AGVGHDF 551
            ++V DINDN P F S      + E+  +G L     A D DAG N    Y L AG     
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 552  PFTINNGTGW------ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605
             F +            + V   LDRE  D Y   ++ +D G+P   +SA + VTVLD ND
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275

Query: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSG 663
            N P F +P Y   L+E++ +G SV+ V A D D  A++ I Y         R  +     
Sbjct: 276  NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335

Query: 664  GGLVSLALPLDYK---LERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQS------ 714
             GL+++  P+D +     R  VLA       +   AQ+VV V D N + P  +       
Sbjct: 336  TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395

Query: 715  SHYT--VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDADTGA----- 766
            +H     N++ED    T V L+  +D D GENA +T  +   +P Q R  ++TG+     
Sbjct: 396  THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455

Query: 767  --VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
              + T   LDYE    YT+ I A D+G P  S T  L++ V DVNDNAP F +   + + 
Sbjct: 456  YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515

Query: 825  YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENV 884
             E+  P   + +I+A+D DSG N  + Y+ +      G F +   +G ++    LDRE  
Sbjct: 516  PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQR 575

Query: 885  AQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVT 944
              Y L+  A D+G P  +    V V VLD NDN P F    ++  V EN P    V  VT
Sbjct: 576  ESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVT 635

Query: 945  ATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLV 1004
              D D+G NAQ+   + + N   V Q    +G + + +  D E +  Y   ++A    + 
Sbjct: 636  VIDGDKGENAQVQLSVEQDNGDFVIQNG--TGTILSSLSFDREQQSTYTFQLKAVDGGVP 693

Query: 1005 SRAT---VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDS 1059
             R+    V + +LD NDN P +       +  +T ++    G  + +V A D D  ++  
Sbjct: 694  PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL--GETVSQVAAEDFDSGVNAE 751

Query: 1060 LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            L YS   GN   L  + + +G + L + ++        + V VSD
Sbjct: 752  LIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  311 bits (796), Expect = 8e-84
 Identities = 222/742 (29%), Positives = 347/742 (46%), Gaps = 65/742 (8%)

Query: 320  PNANILYRLLEGSGGSPSEVFEIDPRSG-VIRTRGPVDREEVESYQ-----------LTV 367
            P+   LY+L  G+         +D ++G +  T   +DRE +   Q             V
Sbjct: 84   PDVGHLYKLEVGA-----PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEV 138

Query: 368  EASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRD 427
              +D  ++  PR     +   V+D NDN P F+     + + E+   G+      ASDRD
Sbjct: 139  SITDLVQNGSPRLLEGQI--EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 428  KGSNAVVHYSIMSGNARGQFY-------LDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
             G N V  Y + +G    + +        + +   L V+  LD E    Y L ++ QDGG
Sbjct: 197  AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256

Query: 481  RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
             PP ++ S L+ V VLD NDNAP F    ++A + E+ P+G+ V+ V+A D+D G NA +
Sbjct: 257  SPPRAS-SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315

Query: 541  EYRLAGVGHDFP------FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
            EY      H  P        ++  TG I+V   +DRE++    F V A+D GT   +A A
Sbjct: 316  EYTF----HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARA 371

Query: 595  SVSVTVLDVNDNNPTF--------TQPEYTVRLNEDAAVGTSVVTVSAVDRD-AHSVITY 645
             V VTV D+NDN PT         T  +    ++ED A  T+V  V   DRD   +    
Sbjct: 372  QVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT 431

Query: 646  QITSGNTRNRFSITSQSGGG-----LVSLALPLDYKLERQYVLAVTASDGTR---QDTAQ 697
             + +G+   +    S++G        +    PLDY+  + Y + + A D        T  
Sbjct: 432  CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNS 491

Query: 698  IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
            + V V D N + PVF  S   V   E+   G  +  I+A+D D+G NA + Y +E     
Sbjct: 492  LKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAA 551

Query: 758  ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQ 814
               F I  +TG +  +  LD E + SY L + A D G P    T  + + V D NDN P+
Sbjct: 552  KGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPK 611

Query: 815  FLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVR 874
            F+   Y  SV E++P  + V  ++  D D G N +V  +    +  +GDF++++ +G + 
Sbjct: 612  FMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTIL 668

Query: 875  TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVF--EQDEFDVFVEE 932
            +    DRE  + Y  +  AVD G+PP    + VT+ VLD NDN P      +     +  
Sbjct: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728

Query: 933  NSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY 992
             + +G  V++V A D D G NA+++Y I  GN   +FQ+   SG +T   +++      +
Sbjct: 729  QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788

Query: 993  VLVIQAT---SAPLVSRATVHV 1011
             LV++ +     P    A VH+
Sbjct: 789  RLVVKVSDRGKPPRYGTALVHL 810



 Score =  298 bits (763), Expect = 5e-80
 Identities = 213/670 (31%), Positives = 323/670 (48%), Gaps = 45/670 (6%)

Query: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
           N NT P F  P     +PEN   G+      A D D G  G   Y + A     + + F 
Sbjct: 162 NDNT-PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA--GPEAQELFG 218

Query: 234 LDPVTGA------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP 287
           L            +     LDRE   ++   +  QD G P R++ A L + V DTND+ P
Sbjct: 219 LQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAP 278

Query: 288 VFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
            FE+  Y+  L EN  +G+ V+ V+A D D   NA I Y   + +      +  +D  +G
Sbjct: 279 KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNTG 337

Query: 348 VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQF-------- 399
           +I  +GPVDRE++ + + +V A D+G +  P+S  A V ++V+D NDNAP          
Sbjct: 338 LITVQGPVDREDLSTLRFSVLAKDRGTN--PKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395

Query: 400 SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA---- 455
           + +  +  + EDV     V  V  SDRD+G NA V   +++G+   Q    ++TG+    
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQLRQASETGSDSKK 454

Query: 456 ---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
              L   +PLDYE  K+YT+ + A D G PPLS+ + L  VQV+D+NDNAP+F  +  + 
Sbjct: 455 KYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDNAPVFTQSVTEV 513

Query: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRL----AGVGHDFPFTINNGTGWISVAAEL 568
              E+   G ++  + A DAD+G NA L Y L    A  G    FTI+  TG I V   L
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG---LFTISPETGEIQVKTSL 570

Query: 569 DREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTS 628
           DRE+ + Y   V A D G+P+L  +A+V V VLD NDN+P F    Y   + E+    + 
Sbjct: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630

Query: 629 VVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
           V  V+ +D D       Q++       F I  Q+G G +  +L  D + +  Y   + A 
Sbjct: 631 VGMVTVIDGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAV 688

Query: 689 DG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVN--VNEDRPAGTTVVLISATDEDTGE 743
           DG    R     + +NV D N + P   +   T +  +      G TV  ++A D D+G 
Sbjct: 689 DGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGV 748

Query: 744 NARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
           NA + Y +    P   F+I + +GA+T + E++      + L +   D G P +  T  +
Sbjct: 749 NAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808

Query: 802 EILVNDVNDN 811
            + VN+   N
Sbjct: 809 HLYVNETLAN 818



 Score =  276 bits (707), Expect = 2e-73
 Identities = 235/763 (30%), Positives = 352/763 (46%), Gaps = 77/763 (10%)

Query: 190 VPENQPAGTPVASLRAID--PDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAE-E 246
           VPE QP  T + SL A    PD G   +LE             +  +D  TG + T E  
Sbjct: 64  VPEEQPPNTLIGSLAADYGFPDVGHLYKLEV---------GAPYLRVDGKTGDIFTTETS 114

Query: 247 LDRE-----------TKSTHVFRVTAQD---HGMPRRSALATLTILVTDTNDHDPVFEQQ 292
           +DRE                 F V+  D   +G PR   L    I V D ND+ P F   
Sbjct: 115 IDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR---LLEGQIEVQDINDNTPNFASP 171

Query: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI------DPRS 346
               ++ EN  +G       A+D DA PN    Y L   +G    E+F +      + + 
Sbjct: 172 VITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL--QAGPEAQELFGLQVAEDQEEKQ 229

Query: 347 GVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVV 406
             +   G +DRE  +SY LT++  D G    PR+++A + ++V D NDNAP+F    Y  
Sbjct: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSP--PRASSALLRVTVLDTNDNAPKFERPSYEA 287

Query: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN--ARGQFYLDAQTGALDVVSPLDY 464
           ++ E+   G  V++V A+D D+G+NA + Y+        R    LD  TG + V  P+D 
Sbjct: 288 ELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDR 347

Query: 465 ETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP--------IFVSTPFQATVLE 516
           E        V A+D G  P S     V V V D+NDNAP        +       A + E
Sbjct: 348 EDLSTLRFSVLAKDRGTNPKS-ARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406

Query: 517 SVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TG-------WISVAAE 567
            V     V  VQ  D D G+NA +   +AG   D PF +     TG       ++     
Sbjct: 407 DVAEETAVALVQVSDRDEGENAAVTCVVAG---DVPFQLRQASETGSDSKKKYFLQTTTP 463

Query: 568 LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGT 627
           LD E+V  Y+  + A D G P L+++ S+ V V+DVNDN P FTQ    V   E+   G 
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523

Query: 628 SVVTVSAVDRD--AHSVITYQI-TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
            +  ++A D D  +++ + Y +      +  F+I+ ++G   + +   LD +    Y L 
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE--IQVKTSLDREQRESYELK 581

Query: 685 VTASD---GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT 741
           V A+D    + Q TA ++VNV D N + P F  S Y  +V E+ PA + V +++  D D 
Sbjct: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDK 641

Query: 742 GENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
           GENA++   +E     F I   TG + +    D E Q +YT  + A D G+P +S    +
Sbjct: 642 GENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGV 701

Query: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFT----SVLQISATDRDSGLNGRVFYTFQGG 857
            I V D NDNAP     S   + ++ + P T    +V Q++A D DSG+N  + Y+  GG
Sbjct: 702 TINVLDENDNAPYITAPS--NTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759

Query: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900
           +   G F + S SG +   + ++R +   + L     D+G PP
Sbjct: 760 NP-YGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPP 801



 Score =  262 bits (669), Expect = 4e-69
 Identities = 199/645 (30%), Positives = 298/645 (46%), Gaps = 37/645 (5%)

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-AGVGHDF 551
            ++V DINDN P F S      + E+  +G L     A D DAG N    Y L AG     
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 552  PFTINNGTGW------ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605
             F +            + V   LDRE  D Y   ++ +D G+P   +SA + VTVLD ND
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275

Query: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSG 663
            N P F +P Y   L+E++ +G SV+ V A D D  A++ I Y         R  +     
Sbjct: 276  NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335

Query: 664  GGLVSLALPLDYK---LERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQS------ 714
             GL+++  P+D +     R  VLA       +   AQ+VV V D N + P  +       
Sbjct: 336  TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395

Query: 715  SHYT--VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDADTGA----- 766
            +H     N++ED    T V L+  +D D GENA +T  +   +P Q R  ++TG+     
Sbjct: 396  THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455

Query: 767  --VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
              + T   LDYE    YT+ I A D+G P  S T  L++ V DVNDNAP F +   + + 
Sbjct: 456  YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515

Query: 825  YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENV 884
             E+  P   + +I+A+D DSG N  + Y+ +      G F +   +G ++    LDRE  
Sbjct: 516  PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQR 575

Query: 885  AQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVT 944
              Y L+  A D+G P  +    V V VLD NDN P F    ++  V EN P    V  VT
Sbjct: 576  ESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVT 635

Query: 945  ATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLV 1004
              D D+G NAQ+   + + N   V Q    +G + + +  D E +  Y   ++A    + 
Sbjct: 636  VIDGDKGENAQVQLSVEQDNGDFVIQNG--TGTILSSLSFDREQQSTYTFQLKAVDGGVP 693

Query: 1005 SRAT---VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDS 1059
             R+    V + +LD NDN P +       +  +T ++    G  + +V A D D  ++  
Sbjct: 694  PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL--GETVSQVAAEDFDSGVNAE 751

Query: 1060 LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
            L YS   GN   L  + + +G + L + ++        + V VSD
Sbjct: 752  LIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
           sapiens]
          Length = 1021

 Score =  310 bits (794), Expect = 1e-83
 Identities = 221/696 (31%), Positives = 350/696 (50%), Gaps = 48/696 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 188

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 363

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             +  V A+DAD+G NA++ Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFT 539

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 540 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655

Query: 695 TAQIVVNVTDANTHRPVF----QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF 750
           +A++ +NV D N ++PVF     +  Y + +    P GT V  + A D DTG NA + Y 
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 714

Query: 751 M--EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVND 807
           +   ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774

Query: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
              NA   + +  + S    V P T +  +S+   D
Sbjct: 775 SVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809



 Score =  289 bits (739), Expect = 3e-77
 Identities = 224/753 (29%), Positives = 352/753 (46%), Gaps = 62/753 (8%)

Query: 316  GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
            GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 70   GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115

Query: 376  PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
            P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 116  PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175

Query: 436  YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
            Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 176  YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 234

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 235  LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294

Query: 551  FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                 F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 295  IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 352

Query: 608  PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
            P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 353  PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
             S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 413  -SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
            TV++ E+   G  +  +SA D D+G NA+I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
             +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y   V E++P   +V  
Sbjct: 532  KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591

Query: 837  ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
            I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 592  ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 897  GMPPARTPMEVTVTVLDVNDNPPVF----EQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
            G     +  +VT+ V+DVNDN PVF        +++ +   +P G  V +V A D D G 
Sbjct: 649  GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707

Query: 953  NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED--------------RPE---YVLV 995
            NA++ Y IV GN  ++F +D  +G +T +   D  D              +P+    V++
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 996  IQATSAPLVSRATVHVRLLDRNDNPPVLGNFEI 1028
            +       V+ AT+   L+ ++   PV  N EI
Sbjct: 768  VNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800



 Score =  281 bits (719), Expect = 7e-75
 Identities = 202/629 (32%), Positives = 312/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 122  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 242  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 302  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 360  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 418

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
             T A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 419  ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   + ++SA D DSG N ++ Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 479  NSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKY 536

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E++ +V EN P    V  +T TD
Sbjct: 537  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 597  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNN--YVTNRSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +  +N  Y     S+ PG  + +V A D D  ++  +
Sbjct: 655  SSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 711

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 712  RYSIVGGNTRDLFAIDQETGNITLMEKCD 740



 Score =  280 bits (716), Expect = 1e-74
 Identities = 223/759 (29%), Positives = 353/759 (46%), Gaps = 48/759 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 34  MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 91

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 92  DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 151

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 212 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 330 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 386

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 387 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  +  VSA+D D+  ++ I Y
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY 503

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 504 -LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 561 IDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 620

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL----RD 818
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+      
Sbjct: 621 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNC 680

Query: 819 SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
           SY+  V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + +
Sbjct: 681 SYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEK 738

Query: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
            D  ++  + +   A D G P +     V +  L VN++
Sbjct: 739 CDVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 775



 Score =  218 bits (554), Expect = 9e-56
 Identities = 179/614 (29%), Positives = 291/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 61   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 117

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 118  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 178  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 237

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 238  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 297

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 298  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 354

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 355  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 413

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++ T   LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 414  NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 473

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+A D D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 474  SIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK 532

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  +N YV         G 
Sbjct: 533  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YNFYVPENLPRH--GT 588

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 589  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 649  -GRVSRSSSAKVTI 661


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  310 bits (794), Expect = 1e-83
 Identities = 221/696 (31%), Positives = 350/696 (50%), Gaps = 48/696 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 188

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 363

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             +  V A+DAD+G NA++ Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFT 539

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 540 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655

Query: 695 TAQIVVNVTDANTHRPVF----QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF 750
           +A++ +NV D N ++PVF     +  Y + +    P GT V  + A D DTG NA + Y 
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 714

Query: 751 M--EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVND 807
           +   ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774

Query: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
              NA   + +  + S    V P T +  +S+   D
Sbjct: 775 SVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809



 Score =  289 bits (739), Expect = 3e-77
 Identities = 224/753 (29%), Positives = 352/753 (46%), Gaps = 62/753 (8%)

Query: 316  GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
            GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 70   GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115

Query: 376  PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
            P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 116  PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175

Query: 436  YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
            Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 176  YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 234

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 235  LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294

Query: 551  FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                 F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 295  IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 352

Query: 608  PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
            P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 353  PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
             S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 413  -SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
            TV++ E+   G  +  +SA D D+G NA+I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
             +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y   V E++P   +V  
Sbjct: 532  KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591

Query: 837  ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
            I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 592  ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 897  GMPPARTPMEVTVTVLDVNDNPPVF----EQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
            G     +  +VT+ V+DVNDN PVF        +++ +   +P G  V +V A D D G 
Sbjct: 649  GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707

Query: 953  NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED--------------RPE---YVLV 995
            NA++ Y IV GN  ++F +D  +G +T +   D  D              +P+    V++
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 996  IQATSAPLVSRATVHVRLLDRNDNPPVLGNFEI 1028
            +       V+ AT+   L+ ++   PV  N EI
Sbjct: 768  VNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800



 Score =  281 bits (719), Expect = 7e-75
 Identities = 202/629 (32%), Positives = 312/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 122  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 242  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 302  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 360  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 418

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
             T A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 419  ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   + ++SA D DSG N ++ Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 479  NSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKY 536

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E++ +V EN P    V  +T TD
Sbjct: 537  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 597  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNN--YVTNRSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +  +N  Y     S+ PG  + +V A D D  ++  +
Sbjct: 655  SSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 711

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 712  RYSIVGGNTRDLFAIDQETGNITLMEKCD 740



 Score =  280 bits (716), Expect = 1e-74
 Identities = 223/759 (29%), Positives = 353/759 (46%), Gaps = 48/759 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 34  MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 91

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 92  DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 151

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 212 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 330 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 386

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 387 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  +  VSA+D D+  ++ I Y
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY 503

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 504 -LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 561 IDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 620

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL----RD 818
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+      
Sbjct: 621 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNC 680

Query: 819 SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
           SY+  V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + +
Sbjct: 681 SYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEK 738

Query: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
            D  ++  + +   A D G P +     V +  L VN++
Sbjct: 739 CDVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 775



 Score =  218 bits (554), Expect = 9e-56
 Identities = 179/614 (29%), Positives = 291/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 61   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 117

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 118  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 178  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 237

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 238  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 297

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 298  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 354

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 355  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 413

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++ T   LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 414  NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 473

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+A D D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 474  SIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK 532

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  +N YV         G 
Sbjct: 533  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YNFYVPENLPRH--GT 588

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 589  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 649  -GRVSRSSSAKVTI 661


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score =  310 bits (794), Expect = 1e-83
 Identities = 221/696 (31%), Positives = 350/696 (50%), Gaps = 48/696 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 188

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 363

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             +  V A+DAD+G NA++ Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFT 539

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 540 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655

Query: 695 TAQIVVNVTDANTHRPVF----QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF 750
           +A++ +NV D N ++PVF     +  Y + +    P GT V  + A D DTG NA + Y 
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 714

Query: 751 M--EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVND 807
           +   ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774

Query: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
              NA   + +  + S    V P T +  +S+   D
Sbjct: 775 SVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809



 Score =  289 bits (739), Expect = 3e-77
 Identities = 224/753 (29%), Positives = 352/753 (46%), Gaps = 62/753 (8%)

Query: 316  GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
            GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 70   GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115

Query: 376  PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
            P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 116  PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175

Query: 436  YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
            Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 176  YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 234

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 235  LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294

Query: 551  FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                 F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 295  IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 352

Query: 608  PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
            P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 353  PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
             S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 413  -SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
            TV++ E+   G  +  +SA D D+G NA+I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
             +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y   V E++P   +V  
Sbjct: 532  KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591

Query: 837  ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
            I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 592  ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 897  GMPPARTPMEVTVTVLDVNDNPPVF----EQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
            G     +  +VT+ V+DVNDN PVF        +++ +   +P G  V +V A D D G 
Sbjct: 649  GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707

Query: 953  NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED--------------RPE---YVLV 995
            NA++ Y IV GN  ++F +D  +G +T +   D  D              +P+    V++
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 996  IQATSAPLVSRATVHVRLLDRNDNPPVLGNFEI 1028
            +       V+ AT+   L+ ++   PV  N EI
Sbjct: 768  VNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800



 Score =  281 bits (719), Expect = 7e-75
 Identities = 202/629 (32%), Positives = 312/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 122  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 242  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 302  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 360  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 418

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
             T A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 419  ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   + ++SA D DSG N ++ Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 479  NSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKY 536

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E++ +V EN P    V  +T TD
Sbjct: 537  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 597  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNN--YVTNRSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +  +N  Y     S+ PG  + +V A D D  ++  +
Sbjct: 655  SSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 711

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 712  RYSIVGGNTRDLFAIDQETGNITLMEKCD 740



 Score =  280 bits (716), Expect = 1e-74
 Identities = 223/759 (29%), Positives = 353/759 (46%), Gaps = 48/759 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 34  MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 91

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 92  DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 151

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 212 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 330 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 386

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 387 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  +  VSA+D D+  ++ I Y
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY 503

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 504 -LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 561 IDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 620

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL----RD 818
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+      
Sbjct: 621 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNC 680

Query: 819 SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
           SY+  V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + +
Sbjct: 681 SYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEK 738

Query: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
            D  ++  + +   A D G P +     V +  L VN++
Sbjct: 739 CDVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 775



 Score =  218 bits (554), Expect = 9e-56
 Identities = 179/614 (29%), Positives = 291/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 61   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 117

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 118  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 178  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 237

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 238  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 297

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 298  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 354

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 355  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 413

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++ T   LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 414  NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 473

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+A D D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 474  SIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK 532

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  +N YV         G 
Sbjct: 533  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YNFYVPENLPRH--GT 588

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 589  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 649  -GRVSRSSSAKVTI 661


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
           sapiens]
          Length = 1025

 Score =  310 bits (794), Expect = 1e-83
 Identities = 221/696 (31%), Positives = 350/696 (50%), Gaps = 48/696 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F       ++PEN    +      A+DPD G  G   Y +      +S   F LD
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL-----IKSQNIFGLD 188

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            +          +   +ELDRE K T+V +V  +D G P+RS+ A L + VTDTND+ PV
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ E + S+ EN  VG  V  + ATD D   NA I +            +F ++  +G+
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ- 407
           I  + P+DREE  +++L V ASD G  P      A V ++V D NDN P   + RY+V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNP 363

Query: 408 ------VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP 461
                 + E++     +  +T +D+D   N  V              + +    L+  + 
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
           LDYE+TKEY +++ A D G+PPL N S ++ ++V D NDNAP+F  +    ++ E+   G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482

Query: 522 YLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFG 579
             +  V A+DAD+G NA++ Y L   G D P  F+++  TG ++V  +LDRE+ D Y F 
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFT 539

Query: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED-AAVGT-SVVTVSAVDR 637
           + A+D+G P LT++ +V V+++D NDN+P FT  EY   + E+    GT  ++TV+  D 
Sbjct: 540 ILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 638 DAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQD 694
             +S +T  I   N  + F+I SQ+  G++   +  D + +  Y   V A DG   +R  
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQT--GVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655

Query: 695 TAQIVVNVTDANTHRPVF----QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF 750
           +A++ +NV D N ++PVF     +  Y + +    P GT V  + A D DTG NA + Y 
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 714

Query: 751 M--EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTYLEILVND 807
           +   ++   F ID +TG +T   + D  D   + + + A D G P        + + VN+
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774

Query: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
              NA   + +  + S    V P T +  +S+   D
Sbjct: 775 SVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809



 Score =  289 bits (739), Expect = 3e-77
 Identities = 224/753 (29%), Positives = 352/753 (46%), Gaps = 62/753 (8%)

Query: 316  GDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
            GD P     L R+ E +G    E+F    R    +    + R+E   Y++ V        
Sbjct: 70   GDVP-----LIRIEEDTG----EIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115

Query: 376  PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVH 435
            P        +   +ED NDNAP F      + + E+    +      A D D G N V +
Sbjct: 116  PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175

Query: 436  YSIM-SGNARGQFYLDAQTG----ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGL 490
            Y ++ S N  G   ++   G     L V   LD E    Y ++V+ +DGG P  S+ + +
Sbjct: 176  YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA-I 234

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + V V D NDN P+F  T  + ++ E+ P+G  V  + A DAD G+NA++ +  + +  +
Sbjct: 235  LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294

Query: 551  FP---FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
                 F +N  TG I++   LDREE   +   V A D G   + A A V V V DVNDN 
Sbjct: 295  IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNV 352

Query: 608  PTF------TQPEYTVRLNEDAAVGTSVVTVSAVDRDA-HSVITYQITSGNTRNRFSITS 660
            P+            TV L+E+  + T +  ++  D+DA H+      T      R     
Sbjct: 353  PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHRPVFQSSHY 717
             S   L+  A  LDY+  ++Y + + A+D  +     +A + + V D N + PVF  S  
Sbjct: 413  -SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 718  TVNVNEDRPAGTTVVLISATDEDTGENARITYFM-EDSIPQFRIDADTGAVTTQAELDYE 776
            TV++ E+   G  +  +SA D D+G NA+I Y +  D+ P+F +D  TG +T   +LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
             +  Y   I A+DNG+P  +    + + + D NDN+P F  + Y   V E++P   +V  
Sbjct: 532  KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591

Query: 837  ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
            I+ TD D G N  V  +    +D   DF ++S +G++R     DRE    Y     A D 
Sbjct: 592  ITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 897  GMPPARTPMEVTVTVLDVNDNPPVF----EQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
            G     +  +VT+ V+DVNDN PVF        +++ +   +P G  V +V A D D G 
Sbjct: 649  GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707

Query: 953  NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED--------------RPE---YVLV 995
            NA++ Y IV GN  ++F +D  +G +T +   D  D              +P+    V++
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 996  IQATSAPLVSRATVHVRLLDRNDNPPVLGNFEI 1028
            +       V+ AT+   L+ ++   PV  N EI
Sbjct: 768  VNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800



 Score =  281 bits (719), Expect = 7e-75
 Identities = 202/629 (32%), Positives = 312/629 (49%), Gaps = 39/629 (6%)

Query: 490  LVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
            LV ++ L  DINDNAP+F +T    ++ E+  +        A+D D G N    Y L   
Sbjct: 122  LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181

Query: 548  GHDFPFTI-----NNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
             + F   +      +    + V  ELDREE D Y   V+  D G P  +++A + V+V D
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241

Query: 603  VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFS 657
             NDN+P F + E  V + E+A VGTSV  + A D D         +  N      R  F 
Sbjct: 242  TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301

Query: 658  ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------ 710
            + + +G  L+++  PLD +    + L V ASDG      A ++VNVTD N + P      
Sbjct: 302  LNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359

Query: 711  VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRID---ADTGAV 767
            +    + TV ++E+ P  T + LI+ TD+D   N R+T F +  IP FR+    ++   +
Sbjct: 360  IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLL 418

Query: 768  TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
             T A LDYE    Y + + A D G P  + +  L I V D NDNAP F +     S+ E+
Sbjct: 419  ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478

Query: 828  VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
              P   + ++SA D DSG N ++ Y    G D   +F ++  +G++  +++LDRE   +Y
Sbjct: 479  NSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKY 536

Query: 888  VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
            +    A D G+PP  + + V V+++D NDN PVF  +E++ +V EN P    V  +T TD
Sbjct: 537  LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596

Query: 948  PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR- 1006
            PD G N+ +   I++ N  + F +D  +G +   +  D E +  Y   ++A     VSR 
Sbjct: 597  PDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654

Query: 1007 --ATVHVRLLDRNDNPPVLGNFEILFNN--YVTNRSSSFPGGAIGRVPAHDPD--ISDSL 1060
              A V + ++D NDN PV   F +  +N  Y     S+ PG  + +V A D D  ++  +
Sbjct: 655  SSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 711

Query: 1061 TYSFERGNELSLVLLNASTGELKLSRALD 1089
             YS   GN   L  ++  TG + L    D
Sbjct: 712  RYSIVGGNTRDLFAIDQETGNITLMEKCD 740



 Score =  280 bits (716), Expect = 1e-74
 Identities = 223/759 (29%), Positives = 353/759 (46%), Gaps = 48/759 (6%)

Query: 190 VPENQPAGTPVASLR-AIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV-TTAEEL 247
           +PEN   G  +  L  ++ P++     +++ +  ++ +       ++  TG + TT   +
Sbjct: 34  MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKL--VYKTGDVPLIRIEEDTGEIFTTGARI 91

Query: 248 DRET------KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
           DRE       +  H F              L  +  L+ D ND+ P+F       S+ EN
Sbjct: 92  DREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPEN 151

Query: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI--DPRSGVIRTRGPVDREE 359
             +  +     A D D   N    Y L++       +V E     +   +  +  +DREE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
            ++Y + V+  D G     RS+TA + +SV D NDN P F E    V + E+   G  V 
Sbjct: 212 KDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269

Query: 420 RVTASDRDKGSNAVVHYS---IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
           ++ A+D D G NA +H+S   ++S  AR  F+L+A TG + +  PLD E T  + L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329

Query: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPI----FVSTPFQATVL--ESVPLGYLVLHVQAI 530
            DGG  P      +V V V D+NDN P     ++  P   TV+  E++PL   +  +   
Sbjct: 330 SDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 386

Query: 531 DADAGDNARLEYRLAGVGHDFPFTIN---NGTGWISVAAELDREEVDFYSFGVEARDHGT 587
           D DA  N R+        H+ PF +    +    +  AA LD E    Y+  + A D G 
Sbjct: 387 DKDADHNGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443

Query: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY 645
           P L  SA + + V D NDN P FTQ   TV + E+ + G  +  VSA+D D+  ++ I Y
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY 503

Query: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNV 702
            +   +    FS+  ++  G++++   LD + E +Y+  + A D           + V++
Sbjct: 504 -LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 560

Query: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
            D N + PVF  + Y   V E+ P   TV LI+ TD D G+N+ +T  + D    F ID+
Sbjct: 561 IDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDS 620

Query: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL----RD 818
            TG +      D E Q SYT  + A D G   +S +  + I V DVNDN P F+      
Sbjct: 621 QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNC 680

Query: 819 SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
           SY+  V     P T V Q+ A D D+G+N  V Y+  GG+  D  F ++  +G +  + +
Sbjct: 681 SYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRD-LFAIDQETGNITLMEK 738

Query: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
            D  ++  + +   A D G P +     V +  L VN++
Sbjct: 739 CDVTDLGLHRVLVKANDLGQPDSL--FSVVIVNLFVNES 775



 Score =  218 bits (554), Expect = 9e-56
 Identities = 179/614 (29%), Positives = 291/614 (47%), Gaps = 47/614 (7%)

Query: 540  LEYRLAGVGHDFPFT-INNGTGWI-SVAAELDREEVDFYSFGVEARDHGTPALTAS---- 593
            ++++L     D P   I   TG I +  A +DRE++     G+   +H    +  +    
Sbjct: 61   MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKL---CAGIPRDEHCFYEVEVAILPD 117

Query: 594  -----ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
                   +   + D+NDN P F      + + E++A+ +     +AVD D   + V  Y+
Sbjct: 118  EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177

Query: 647  -ITSGNTRNRFSITSQSGGGLVSLALP--LDYKLERQYVLAVTASDG---TRQDTAQIVV 700
             I S N      I +  G  +  L +   LD + +  YV+ V   DG    R  TA + V
Sbjct: 178  LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQV 237

Query: 701  NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--- 757
            +VTD N + PVF+ +   V++ E+ P GT+V  + ATD D GENA+I +   + +     
Sbjct: 238  SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 297

Query: 758  --FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI-PQKSDTTYLEILVNDVNDNAP- 813
              F ++A TG +T +  LD E+  ++ L + A D G+ P ++    + + V DVNDN P 
Sbjct: 298  RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPS 354

Query: 814  ---QFLRDSYQGSVY--EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
               +++ +    +V   E++P  T +  I+ TD+D+  NGRV   F   +       V S
Sbjct: 355  IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDHEIPFRLRPVFS 413

Query: 869  TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
               ++ T   LD E+  +Y ++  A D G PP      + + V D NDN PVF Q    V
Sbjct: 414  NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 473

Query: 929  FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
             + EN+  G+ + +V+A D D G NA+I Y ++  + P  F LD  +G LT +  LD E 
Sbjct: 474  SIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK 532

Query: 989  RPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
              +Y+  I A      PL S  TV V ++D+NDN PV  + E  +N YV         G 
Sbjct: 533  EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YNFYVPENLPRH--GT 588

Query: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
            +G +   DPD  D+   +    +E     +++ TG ++ + + D  +       V   DG
Sbjct: 589  VGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648

Query: 1106 VHSVTAQCALRVTI 1119
               V+   + +VTI
Sbjct: 649  -GRVSRSSSAKVTI 661


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  295 bits (755), Expect = 4e-79
 Identities = 215/717 (29%), Positives = 352/717 (49%), Gaps = 43/717 (5%)

Query: 295 KESLRENLEVGY--EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG-VIRT 351
           +E L EN+ +G   + L +   +     +A+++YRL+  +G +P  + ++   +G +  T
Sbjct: 31  REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAP--LVKVSSSTGEIFTT 88

Query: 352 RGPVDREEVESYQLTVEASDQGRD------PGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405
              +DRE++ +     E ++   +      P        + + V+D NDNAP F      
Sbjct: 89  SNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGA----LDVVS 460
           + + E+    +     +A+D D G N V HY +++G +  G   ++   G     L V  
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
            LD E    Y ++++ +DGG P  S+ + ++ V V D+NDN P+F     +  + E+ P+
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQKSSTA-ILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267

Query: 521 GYLVLHVQAIDADAGDNARLEYRLAGVGHDFP---FTINNGTGWISVAAELDREEVDFYS 577
           G  V+ + A DAD G NA + Y             F +NN TG I+V   LDREE   + 
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327

Query: 578 FGVEARD-HGTPALTASASVSVTVLDVNDNNPTF------TQPEYTVRLNEDAAVGTSV- 629
             V A D   TPA    A+V++ V DVNDN P        +    TV L+E   V T + 
Sbjct: 328 VTVLASDGSSTPA---RATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384

Query: 630 -VTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
            +TVS  D D +  +   I      +  ++       L+  +  LDY+  +++   + AS
Sbjct: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY--LLETSSLLDYEGTKEFSFKIVAS 442

Query: 689 DGTR---QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA 745
           D  +     TA + V + D N + P+F      ++V+E+   G  +  ISATDED+G+NA
Sbjct: 443 DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502

Query: 746 RITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            I Y +  +   F +D  TG +T     D E+Q  +   +TARDNG P       + + V
Sbjct: 503 DIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV 562

Query: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865
            D NDN+P+F  + +Q  V E++P +++V  I+ TD D+G N  V  +    +D   +F+
Sbjct: 563 LDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND---NFV 619

Query: 866 VESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDE 925
           ++  SG++++    DRE  + Y     A D G PP  +  +VT+ V+DVNDN PV     
Sbjct: 620 LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP 679

Query: 926 FDV---FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
            +     V  ++  G  VA V A D D G NA++ Y IV GN   +F++D  +G +T
Sbjct: 680 SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNIT 736



 Score =  271 bits (694), Expect = 5e-72
 Identities = 209/663 (31%), Positives = 315/663 (47%), Gaps = 44/663 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F  P    ++PEN    +      A DPD G  G   Y +           F LD
Sbjct: 137 DNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL-----LNGQSVFGLD 191

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            V          +   + LDRE K T+V ++  +D G P++S+ A L + V+D ND+ PV
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ + +  + EN  VG  V+ + ATD D   NA I Y        +   +F ++  +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV--- 405
           I  +  +DREE   +++TV ASD    P      A V ++V D NDN P   + RY+   
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTP----ARATVTINVTDVNDNPPNI-DLRYIISP 366

Query: 406 ----VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDA---QTGALDV 458
               V + E       +  +T SD+D   N  V   I        F+L A       L+ 
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKV---ICFIEREVPFHLKAVYDNQYLLET 423

Query: 459 VSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESV 518
            S LDYE TKE++ ++ A D G+P L N + LV V++ D NDN PIF     + +V E+ 
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 519 PLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSF 578
             G  +  + A D D+G NA + Y+L G    F F ++  TG ++ +   DREE + + F
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL-GPNASF-FDLDRKTGVLTASRVFDREEQERFIF 540

Query: 579 GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
            V ARD+GTP L + A+V VTVLD NDN+P FT   +   ++E+    ++V  ++  D D
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600

Query: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDT 695
           A       ++  N  + F +   S  G++   +  D + +  Y   V A+DG    R  T
Sbjct: 601 AGENKAVTLSILNDNDNFVLDPYS--GVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658

Query: 696 AQIVVNVTDANTHRPVFQSSHYTVN---VNEDRPAGTTVVLISATDEDTGENARITYFME 752
           A++ +NV D N + PV  S     +   V      G+ V  + A D DTG NA + Y + 
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718

Query: 753 DSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL-VNDVN 809
               +  FRID  TG +T + +    D   + L +   D G P+   T  L  L VND  
Sbjct: 719 SGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTA 778

Query: 810 DNA 812
            NA
Sbjct: 779 GNA 781



 Score =  261 bits (668), Expect = 5e-69
 Identities = 195/619 (31%), Positives = 297/619 (47%), Gaps = 34/619 (5%)

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + + V D NDNAP+F S     ++ E+  +        A D D G N    Y L      
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 551  FPFTI---NNGTGW--ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605
            F   I     G  W  + V   LDRE+ D Y   ++  D GTP  +++A + VTV DVND
Sbjct: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVND 247

Query: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFSITS 660
            N P F + +  V + E+A VGTSV+ + A D D  S    +   G      T+  F++ +
Sbjct: 248  NRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNN 307

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------VFQ 713
             +G  L+++   LD +    + + V ASDG+     A + +NVTD N + P      +  
Sbjct: 308  TTG--LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIIS 365

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA---DTGAVTTQ 770
              + TV ++E  P  T + LI+ +D+DT  N ++  F+E  +P F + A   +   + T 
Sbjct: 366  PINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETS 424

Query: 771  AELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP 830
            + LDYE    ++  I A D+G P  + T  + + + D NDN P F +   + SV E+   
Sbjct: 425  SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484

Query: 831  FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLR 890
               +  ISATD DSG N  + Y  Q G +    F ++  +G++   R  DRE   +++  
Sbjct: 485  GLYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTASRVFDREEQERFIFT 541

Query: 891  AYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDE 950
              A D G PP ++   V VTVLD NDN P F  + F  FV EN P    V  +T TD D 
Sbjct: 542  VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601

Query: 951  GTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRA 1007
            G N  +   I+  N  + F LD +SG + + V  D E +  Y   ++AT     P  S A
Sbjct: 602  GENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTA 659

Query: 1008 TVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFE 1065
             V + ++D NDN PV+ +      ++     S+ PG  +  V A D D  ++  L Y+  
Sbjct: 660  KVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718

Query: 1066 RGNELSLVLLNASTGELKL 1084
             GN   L  ++  TG + L
Sbjct: 719  SGNNKGLFRIDPVTGNITL 737



 Score =  246 bits (628), Expect = 2e-64
 Identities = 194/668 (29%), Positives = 322/668 (48%), Gaps = 39/668 (5%)

Query: 272 LATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG 331
           L  + I+V DTND+ P+F       S+ EN  +        ATD D   N    Y LL G
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 332 SGGSPSEVFEI--DPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV 389
                 ++ E     +   +  +  +DRE+ ++Y + ++  D G     +S+TA + ++V
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVTV 242

Query: 390 EDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHY---SIMSGNARGQ 446
            D NDN P F E +  V + E+   G  V+++ A+D D GSNA + Y   + ++   +  
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302

Query: 447 FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP--- 503
           F L+  TG + V   LD E T  + + V A DG   P       VT+ V D+NDN P   
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNID 359

Query: 504 -IFVSTPFQATVL--ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF---TINN 557
             ++ +P   TV   E  P+   +  +   D D   N ++   +  +  + PF    + +
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV---ICFIEREVPFHLKAVYD 416

Query: 558 GTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTV 617
               +  ++ LD E    +SF + A D G P+L  +A V V + D NDN P F QP   +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476

Query: 618 RLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDY 675
            ++E+   G  + T+SA D D+  ++ I YQ+  G   + F +  ++  G+++ +   D 
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKT--GVLTASRVFDR 532

Query: 676 KLERQYVLAVTASD-GT--RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
           + + +++  VTA D GT   Q  A ++V V D N + P F  +H+   V+E+ P  +TV 
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVG 592

Query: 733 LISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI 792
           +I+ TD D GEN  +T  + +    F +D  +G + +    D E Q SYT  + A D G 
Sbjct: 593 VITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652

Query: 793 PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP----PFTSVLQISATDRDSGLNG 848
           P +S T  + I V DVNDN+P  +      S ++ VP    P + V ++ A D D+G+N 
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 849 RVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT 908
            + YT   G++  G F ++  +G +    +    +V  + L     D G P  ++   + 
Sbjct: 712 ELKYTIVSGNN-KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYP--KSLHTLV 768

Query: 909 VTVLDVND 916
           +  L VND
Sbjct: 769 LVFLYVND 776



 Score =  216 bits (551), Expect = 2e-55
 Identities = 183/655 (27%), Positives = 299/655 (45%), Gaps = 68/655 (10%)

Query: 516  ESVPLGYLV--LHVQAIDADAGDNARLEYRLAGVGHDFPFT-INNGTGWI-SVAAELDRE 571
            E+VP+G +   L++  I+A  G +A L YRL     D P   +++ TG I + +  +DRE
Sbjct: 36   ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95

Query: 572  EVD-----------FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLN 620
            ++            F+   V    +    L     + + V D NDN P F  P   + + 
Sbjct: 96   KLCAGASYAEENECFFELEVVILPNDFFRLI---KIKIIVKDTNDNAPMFPSPVINISIP 152

Query: 621  EDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGL---VSLALPLDY 675
            E+  + +     SA D D   + V  Y++ +G +     I     G     + +   LD 
Sbjct: 153  ENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDR 212

Query: 676  KLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
            + +  YV+ +   DG    +  TA + V V+D N +RPVF+     V++ E+ P GT+V+
Sbjct: 213  EQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVI 272

Query: 733  LISATDEDTGENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA 787
             + ATD D G NA I Y     +       F ++  TG +T Q  LD E+   + + + A
Sbjct: 273  QLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332

Query: 788  RD-NGIPQKSDTTYLEILVNDVNDNAP----QFLRDSYQGSVY--EDVPPFTSVLQISAT 840
             D +  P ++  T   I V DVNDN P    +++     G+VY  E  P  T +  I+ +
Sbjct: 333  SDGSSTPARATVT---INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVS 389

Query: 841  DRDSGLNGRVF------YTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
            D+D+ +NG+V         F      D  +++E++S        LD E   ++  +  A 
Sbjct: 390  DKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSFKIVAS 442

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNA 954
            D G P       V V + D NDNPP+F Q   ++ V EN+  GL +  ++ATD D G NA
Sbjct: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502

Query: 955  QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHV 1011
             I+YQ+  G     F LD  +G LTA    D E++  ++  + A    + PL S+A V V
Sbjct: 503  DIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560

Query: 1012 RLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG-GAIGRVPAHDPDISDSLTYSFERGNEL 1070
             +LD NDN P     +   N++    S + P    +G +   D D  ++   +    N+ 
Sbjct: 561  TVLDENDNSP-----KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN 615

Query: 1071 SLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG---VHSVTAQCALRVTIITD 1122
               +L+  +G +K + + D  +       V  +DG     S TA+  + V  + D
Sbjct: 616  DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670



 Score =  124 bits (312), Expect = 1e-27
 Identities = 127/467 (27%), Positives = 204/467 (43%), Gaps = 65/467 (13%)

Query: 734  ISATDEDTGENARITYFMEDSI---PQFRIDADTGAV-TTQAELDYE-----------DQ 778
            IS  +  TG +A + Y +       P  ++ + TG + TT   +D E           ++
Sbjct: 49   ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENE 108

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQIS 838
              + L +    N   +      ++I+V D NDNAP F       S+ E+    +     S
Sbjct: 109  CFFELEVVILPNDFFR---LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS 165

Query: 839  ATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG------IVRTLRRLDRENVAQYVLRAY 892
            ATD D+G NG   Y    G    G  IVE+  G      IV+  + LDRE    YV++  
Sbjct: 166  ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQ--QNLDREQKDTYVMKIK 223

Query: 893  AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
              D G P   +   + VTV DVNDN PVF++ + +V + EN+P+G +V ++ ATD D G+
Sbjct: 224  VEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGS 283

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEY-VLVIQATSAPLVSRAT 1008
            NA+I Y       P    +F L+  +G +T    LD E+   + V V+ +  +   +RAT
Sbjct: 284  NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT 343

Query: 1009 VHVRLLDRNDNPPVLGNFEILF-------NNYVTNRSSSFPGGAIGRVPAHDPDISDSLT 1061
            V + + D NDNPP   N ++ +         Y++ +       A+  V   D D++  + 
Sbjct: 344  VTINVTDVNDNPP---NIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVI 400

Query: 1062 YSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIIT 1121
               ER     L  +  +   L+ S  LD     E    ++ SD       Q AL      
Sbjct: 401  CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL------ 454

Query: 1122 DEMLTHSITLRLEDM--SPERFLSPLL----------GLFIQAVAAT 1156
                   + ++LED   +P  F  P++          GL++  ++AT
Sbjct: 455  -------VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  295 bits (755), Expect = 4e-79
 Identities = 215/717 (29%), Positives = 352/717 (49%), Gaps = 43/717 (5%)

Query: 295 KESLRENLEVGY--EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG-VIRT 351
           +E L EN+ +G   + L +   +     +A+++YRL+  +G +P  + ++   +G +  T
Sbjct: 31  REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAP--LVKVSSSTGEIFTT 88

Query: 352 RGPVDREEVESYQLTVEASDQGRD------PGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405
              +DRE++ +     E ++   +      P        + + V+D NDNAP F      
Sbjct: 89  SNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGA----LDVVS 460
           + + E+    +     +A+D D G N V HY +++G +  G   ++   G     L V  
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
            LD E    Y ++++ +DGG P  S+ + ++ V V D+NDN P+F     +  + E+ P+
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQKSSTA-ILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267

Query: 521 GYLVLHVQAIDADAGDNARLEYRLAGVGHDFP---FTINNGTGWISVAAELDREEVDFYS 577
           G  V+ + A DAD G NA + Y             F +NN TG I+V   LDREE   + 
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327

Query: 578 FGVEARD-HGTPALTASASVSVTVLDVNDNNPTF------TQPEYTVRLNEDAAVGTSV- 629
             V A D   TPA    A+V++ V DVNDN P        +    TV L+E   V T + 
Sbjct: 328 VTVLASDGSSTPA---RATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384

Query: 630 -VTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
            +TVS  D D +  +   I      +  ++       L+  +  LDY+  +++   + AS
Sbjct: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY--LLETSSLLDYEGTKEFSFKIVAS 442

Query: 689 DGTR---QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA 745
           D  +     TA + V + D N + P+F      ++V+E+   G  +  ISATDED+G+NA
Sbjct: 443 DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502

Query: 746 RITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            I Y +  +   F +D  TG +T     D E+Q  +   +TARDNG P       + + V
Sbjct: 503 DIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV 562

Query: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865
            D NDN+P+F  + +Q  V E++P +++V  I+ TD D+G N  V  +    +D   +F+
Sbjct: 563 LDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND---NFV 619

Query: 866 VESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDE 925
           ++  SG++++    DRE  + Y     A D G PP  +  +VT+ V+DVNDN PV     
Sbjct: 620 LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP 679

Query: 926 FDV---FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
            +     V  ++  G  VA V A D D G NA++ Y IV GN   +F++D  +G +T
Sbjct: 680 SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNIT 736



 Score =  271 bits (694), Expect = 5e-72
 Identities = 209/663 (31%), Positives = 315/663 (47%), Gaps = 44/663 (6%)

Query: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
           + AP F  P    ++PEN    +      A DPD G  G   Y +           F LD
Sbjct: 137 DNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL-----LNGQSVFGLD 191

Query: 236 PVTGA-------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
            V          +   + LDRE K T+V ++  +D G P++S+ A L + V+D ND+ PV
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
           F++ + +  + EN  VG  V+ + ATD D   NA I Y        +   +F ++  +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311

Query: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV--- 405
           I  +  +DREE   +++TV ASD    P      A V ++V D NDN P   + RY+   
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTP----ARATVTINVTDVNDNPPNI-DLRYIISP 366

Query: 406 ----VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDA---QTGALDV 458
               V + E       +  +T SD+D   N  V   I        F+L A       L+ 
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKV---ICFIEREVPFHLKAVYDNQYLLET 423

Query: 459 VSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESV 518
            S LDYE TKE++ ++ A D G+P L N + LV V++ D NDN PIF     + +V E+ 
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 519 PLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSF 578
             G  +  + A D D+G NA + Y+L G    F F ++  TG ++ +   DREE + + F
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL-GPNASF-FDLDRKTGVLTASRVFDREEQERFIF 540

Query: 579 GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
            V ARD+GTP L + A+V VTVLD NDN+P FT   +   ++E+    ++V  ++  D D
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600

Query: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDT 695
           A       ++  N  + F +   S  G++   +  D + +  Y   V A+DG    R  T
Sbjct: 601 AGENKAVTLSILNDNDNFVLDPYS--GVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658

Query: 696 AQIVVNVTDANTHRPVFQSSHYTVN---VNEDRPAGTTVVLISATDEDTGENARITYFME 752
           A++ +NV D N + PV  S     +   V      G+ V  + A D DTG NA + Y + 
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718

Query: 753 DSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL-VNDVN 809
               +  FRID  TG +T + +    D   + L +   D G P+   T  L  L VND  
Sbjct: 719 SGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTA 778

Query: 810 DNA 812
            NA
Sbjct: 779 GNA 781



 Score =  261 bits (668), Expect = 5e-69
 Identities = 195/619 (31%), Positives = 297/619 (47%), Gaps = 34/619 (5%)

Query: 491  VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
            + + V D NDNAP+F S     ++ E+  +        A D D G N    Y L      
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 551  FPFTI---NNGTGW--ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVND 605
            F   I     G  W  + V   LDRE+ D Y   ++  D GTP  +++A + VTV DVND
Sbjct: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVND 247

Query: 606  NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN-----TRNRFSITS 660
            N P F + +  V + E+A VGTSV+ + A D D  S    +   G      T+  F++ +
Sbjct: 248  NRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNN 307

Query: 661  QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIVVNVTDANTHRP------VFQ 713
             +G  L+++   LD +    + + V ASDG+     A + +NVTD N + P      +  
Sbjct: 308  TTG--LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIIS 365

Query: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA---DTGAVTTQ 770
              + TV ++E  P  T + LI+ +D+DT  N ++  F+E  +P F + A   +   + T 
Sbjct: 366  PINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETS 424

Query: 771  AELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP 830
            + LDYE    ++  I A D+G P  + T  + + + D NDN P F +   + SV E+   
Sbjct: 425  SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484

Query: 831  FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLR 890
               +  ISATD DSG N  + Y  Q G +    F ++  +G++   R  DRE   +++  
Sbjct: 485  GLYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTASRVFDREEQERFIFT 541

Query: 891  AYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDE 950
              A D G PP ++   V VTVLD NDN P F  + F  FV EN P    V  +T TD D 
Sbjct: 542  VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601

Query: 951  GTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRA 1007
            G N  +   I+  N  + F LD +SG + + V  D E +  Y   ++AT     P  S A
Sbjct: 602  GENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTA 659

Query: 1008 TVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFE 1065
             V + ++D NDN PV+ +      ++     S+ PG  +  V A D D  ++  L Y+  
Sbjct: 660  KVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718

Query: 1066 RGNELSLVLLNASTGELKL 1084
             GN   L  ++  TG + L
Sbjct: 719  SGNNKGLFRIDPVTGNITL 737



 Score =  246 bits (628), Expect = 2e-64
 Identities = 194/668 (29%), Positives = 322/668 (48%), Gaps = 39/668 (5%)

Query: 272 LATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG 331
           L  + I+V DTND+ P+F       S+ EN  +        ATD D   N    Y LL G
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 332 SGGSPSEVFEI--DPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV 389
                 ++ E     +   +  +  +DRE+ ++Y + ++  D G     +S+TA + ++V
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVTV 242

Query: 390 EDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHY---SIMSGNARGQ 446
            D NDN P F E +  V + E+   G  V+++ A+D D GSNA + Y   + ++   +  
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302

Query: 447 FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP--- 503
           F L+  TG + V   LD E T  + + V A DG   P       VT+ V D+NDN P   
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNID 359

Query: 504 -IFVSTPFQATVL--ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF---TINN 557
             ++ +P   TV   E  P+   +  +   D D   N ++   +  +  + PF    + +
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV---ICFIEREVPFHLKAVYD 416

Query: 558 GTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTV 617
               +  ++ LD E    +SF + A D G P+L  +A V V + D NDN P F QP   +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476

Query: 618 RLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDY 675
            ++E+   G  + T+SA D D+  ++ I YQ+  G   + F +  ++  G+++ +   D 
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKT--GVLTASRVFDR 532

Query: 676 KLERQYVLAVTASD-GT--RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
           + + +++  VTA D GT   Q  A ++V V D N + P F  +H+   V+E+ P  +TV 
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVG 592

Query: 733 LISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI 792
           +I+ TD D GEN  +T  + +    F +D  +G + +    D E Q SYT  + A D G 
Sbjct: 593 VITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652

Query: 793 PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP----PFTSVLQISATDRDSGLNG 848
           P +S T  + I V DVNDN+P  +      S ++ VP    P + V ++ A D D+G+N 
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 849 RVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT 908
            + YT   G++  G F ++  +G +    +    +V  + L     D G P  ++   + 
Sbjct: 712 ELKYTIVSGNN-KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYP--KSLHTLV 768

Query: 909 VTVLDVND 916
           +  L VND
Sbjct: 769 LVFLYVND 776



 Score =  216 bits (551), Expect = 2e-55
 Identities = 183/655 (27%), Positives = 299/655 (45%), Gaps = 68/655 (10%)

Query: 516  ESVPLGYLV--LHVQAIDADAGDNARLEYRLAGVGHDFPFT-INNGTGWI-SVAAELDRE 571
            E+VP+G +   L++  I+A  G +A L YRL     D P   +++ TG I + +  +DRE
Sbjct: 36   ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95

Query: 572  EVD-----------FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLN 620
            ++            F+   V    +    L     + + V D NDN P F  P   + + 
Sbjct: 96   KLCAGASYAEENECFFELEVVILPNDFFRLI---KIKIIVKDTNDNAPMFPSPVINISIP 152

Query: 621  EDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGL---VSLALPLDY 675
            E+  + +     SA D D   + V  Y++ +G +     I     G     + +   LD 
Sbjct: 153  ENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDR 212

Query: 676  KLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
            + +  YV+ +   DG    +  TA + V V+D N +RPVF+     V++ E+ P GT+V+
Sbjct: 213  EQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVI 272

Query: 733  LISATDEDTGENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA 787
             + ATD D G NA I Y     +       F ++  TG +T Q  LD E+   + + + A
Sbjct: 273  QLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332

Query: 788  RD-NGIPQKSDTTYLEILVNDVNDNAP----QFLRDSYQGSVY--EDVPPFTSVLQISAT 840
             D +  P ++  T   I V DVNDN P    +++     G+VY  E  P  T +  I+ +
Sbjct: 333  SDGSSTPARATVT---INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVS 389

Query: 841  DRDSGLNGRVF------YTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
            D+D+ +NG+V         F      D  +++E++S        LD E   ++  +  A 
Sbjct: 390  DKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSFKIVAS 442

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNA 954
            D G P       V V + D NDNPP+F Q   ++ V EN+  GL +  ++ATD D G NA
Sbjct: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502

Query: 955  QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHV 1011
             I+YQ+  G     F LD  +G LTA    D E++  ++  + A    + PL S+A V V
Sbjct: 503  DIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560

Query: 1012 RLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG-GAIGRVPAHDPDISDSLTYSFERGNEL 1070
             +LD NDN P     +   N++    S + P    +G +   D D  ++   +    N+ 
Sbjct: 561  TVLDENDNSP-----KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN 615

Query: 1071 SLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG---VHSVTAQCALRVTIITD 1122
               +L+  +G +K + + D  +       V  +DG     S TA+  + V  + D
Sbjct: 616  DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670



 Score =  124 bits (312), Expect = 1e-27
 Identities = 127/467 (27%), Positives = 204/467 (43%), Gaps = 65/467 (13%)

Query: 734  ISATDEDTGENARITYFMEDSI---PQFRIDADTGAV-TTQAELDYE-----------DQ 778
            IS  +  TG +A + Y +       P  ++ + TG + TT   +D E           ++
Sbjct: 49   ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENE 108

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQIS 838
              + L +    N   +      ++I+V D NDNAP F       S+ E+    +     S
Sbjct: 109  CFFELEVVILPNDFFR---LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS 165

Query: 839  ATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG------IVRTLRRLDRENVAQYVLRAY 892
            ATD D+G NG   Y    G    G  IVE+  G      IV+  + LDRE    YV++  
Sbjct: 166  ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQ--QNLDREQKDTYVMKIK 223

Query: 893  AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
              D G P   +   + VTV DVNDN PVF++ + +V + EN+P+G +V ++ ATD D G+
Sbjct: 224  VEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGS 283

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEY-VLVIQATSAPLVSRAT 1008
            NA+I Y       P    +F L+  +G +T    LD E+   + V V+ +  +   +RAT
Sbjct: 284  NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT 343

Query: 1009 VHVRLLDRNDNPPVLGNFEILF-------NNYVTNRSSSFPGGAIGRVPAHDPDISDSLT 1061
            V + + D NDNPP   N ++ +         Y++ +       A+  V   D D++  + 
Sbjct: 344  VTINVTDVNDNPP---NIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVI 400

Query: 1062 YSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIIT 1121
               ER     L  +  +   L+ S  LD     E    ++ SD       Q AL      
Sbjct: 401  CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL------ 454

Query: 1122 DEMLTHSITLRLEDM--SPERFLSPLL----------GLFIQAVAAT 1156
                   + ++LED   +P  F  P++          GL++  ++AT
Sbjct: 455  -------VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLD 1096



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 910  ATVTVIVK--DMNDYPPV 925



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 394

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 451

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 506

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 565

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 625  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 738

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 739  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 795

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 972

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 973  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1088

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 116  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 175  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 235  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 295  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 355  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 413  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 468

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 469  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 527

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 528  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 588  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 645

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 646  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 703

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 704  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 762

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 763  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 822

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 823  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 880  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 938  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 998  ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1051

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1052 GNEEDTFGINNITGVIYVNGPLD 1074



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 368  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 421

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 422  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 479

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 480  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 536  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 596  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 653  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 711  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 766

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 767  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 827  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 885  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 945  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1004

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1005 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1058

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 314  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 372

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 373  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 429

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 430  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 484

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 485  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 543

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 544  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 602

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 603  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 659

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 660  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 716

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 717  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 773

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 774  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 833

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 834  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 893

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 894  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 950

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 951  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1010

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1011 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1066

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1067 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121



 Score =  283 bits (723), Expect = 2e-75
 Identities = 256/891 (28%), Positives = 412/891 (46%), Gaps = 106/891 (11%)

Query: 210  EGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV---TTAEELDRETKSTHVFRVTAQDHGM 266
            +G AG  + T++       + +  +DPV   +   +T   LDR+    ++  +  Q   +
Sbjct: 41   KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPM-NIHSIVVQVQCI 99

Query: 267  PRRSALAT---LTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLT-----VRATDGDA 318
             ++        + I+V D ND+ P F+ + Y  ++ E   VG  + T       ATD D 
Sbjct: 100  NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDD 159

Query: 319  PPNANILYRLLEGSGGSP--SEVFEID-PRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
             PN  I Y +++ +   P  ++ FEI    +G I  R  ++ E+   Y + ++A+D+ ++
Sbjct: 160  GPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218

Query: 376  PGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR-----------------EDVTPGAP 417
                R+TT  + + V D +D  P F     V   R                 E++ P   
Sbjct: 219  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278

Query: 418  VLRVTASDRDK-----GSNAVVHYSIMSGNARGQ---FYLDAQTGALDVVSPLDYETTKE 469
               + A D+D+          + YSI+ G        F++  +T  L ++ P++ +  ++
Sbjct: 279  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV----- 524
            + L ++A+     PL   +GL  +++LD N+ +P F    +Q  +LES P+G  +     
Sbjct: 339  FDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397

Query: 525  ----LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TGWISVAAELDREEVDFYSF 578
                L + A+D D  D    E  L    +   FT+     T ++++   +DREE   Y+F
Sbjct: 398  LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457

Query: 579  GVEARD---HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAV 635
             + A D      P +     V++ V+D NDN PTF +  Y V +  D   G SV+ ++AV
Sbjct: 458  SITAFDGVQESEPVI-----VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 512

Query: 636  DRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT-- 691
            D D  ++  ITY+I  G  +  F I   +  GL+++A  ++  + R Y L V A+D    
Sbjct: 513  DADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAPP 569

Query: 692  ---RQDTAQIVVNVTDANTHRPV-FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARI 747
               R     + + V   N   P  F    Y++ ++E    G  ++ + ATD    E   I
Sbjct: 570  AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSI 626

Query: 748  TYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            TY +E+  PQ  F +   TG +T    LD E    Y L ITA D G P  + T  + I+V
Sbjct: 627  TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVV 685

Query: 806  NDVNDNAPQFLRDSY----QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
             DVNDNAP F  D Y       V E+   F  V Q+ ATD D+G+NG+V Y+      G+
Sbjct: 686  TDVNDNAPVF--DPYLPRNLSVVEEEANAF--VGQVKATDPDAGINGQVHYSL-----GN 736

Query: 862  GDFIVESTS-GIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV 920
             + +   TS G + T  +L+RE    Y L   A D  + P  + + + + VLD++DN PV
Sbjct: 737  FNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 796

Query: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
            F    + V VEEN P G  + ++ A D D G N  + Y+I    +   F L  F+GEL+ 
Sbjct: 797  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854

Query: 981  LVDLDYEDRPEY---------VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
            L  LDYE  P+             I  T  P ++  TV V+  D ND PPV
Sbjct: 855  LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPV 903



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 231  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 291  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 351  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 410  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 470  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 530  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 588

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 589  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 644

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 645  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 703

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 704  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 757

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 758  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 812

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 813  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 230  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 290  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 350  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 409  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 464

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 465  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 524  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 583  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 638

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 639  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 687



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 110  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 170  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 230  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 290  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 350  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 410  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 470  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 525

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 526  ILVGAQGDFI-INKTTGLITIAPGVE 550


>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
          Length = 1677

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLD 1096



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 910  ATVTVIVK--DMNDYPPV 925



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 394

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 451

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 506

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 565

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 625  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 738

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 739  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 795

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 972

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 973  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1088

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572


>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
          Length = 1682

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 143  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 202  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 262  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 322  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 382  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 440  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 495

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 496  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 554

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 555  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 614

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 615  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 672

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 673  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 730

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 731  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 789

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 790  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 849

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 850  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 906

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 907  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 964

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 965  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1024

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1025 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1078

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1079 GNEEDTFGINNITGVIYVNGPLD 1101



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 395  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 448

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 449  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 506

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 507  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 562

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 563  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 622

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 623  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 679

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 680  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 738  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 793

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 794  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 853

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 854  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 911

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 912  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 971

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 972  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1031

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1032 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1085

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1086 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1145

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1146 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1205

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1206 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1259



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 44   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 100

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 101  LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 159

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 160  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 218

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 219  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 278

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 279  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 338

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 339  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 397

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 398  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 457

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 458  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 512

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 513  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 569

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 570  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 629

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 630  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 686

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 687  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 741

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 742  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 796

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 797  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 856

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 857  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 914

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 915  ATVTVIVK--DMNDYPPV 930



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 283  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 341  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 399

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 400  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 456

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 457  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 511

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 512  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 570

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 571  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 629

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 630  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 686

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 687  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 743

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 744  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 800

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 801  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 860

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 861  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 920

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 921  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 977

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 978  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1037

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1038 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1093

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1094 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1148



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 138  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 258  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 318  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 378  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 437  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 496

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 497  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 556

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 557  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 615

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 616  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 671

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 672  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 730

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 731  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 784

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 785  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 839

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 840  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 886



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 138  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 257  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 317  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 377  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 436  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 491

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 492  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 550

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 551  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 610  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 665

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 666  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 714



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 137  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 197  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 257  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 317  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 377  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 437  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 496

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 497  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 552

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 553  ILVGAQGDFI-INKTTGLITIAPGVE 577


>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
          Length = 1539

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLD 1096



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 910  ATVTVIVK--DMNDYPPV 925



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 394

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 451

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 506

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 565

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 625  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 738

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 739  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 795

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 972

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 973  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1088

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572


>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
          Length = 1935

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 116  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 175  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 235  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 295  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 355  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 413  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 468

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 469  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 527

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 528  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 588  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 645

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 646  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 703

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 704  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 762

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 763  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 822

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 823  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 880  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 938  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 998  ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1051

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1052 GNEEDTFGINNITGVIYVNGPLD 1074



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 368  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 421

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 422  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 479

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 480  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 536  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 596  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 653  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 711  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 766

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 767  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 827  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 885  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 945  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1004

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1005 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1058

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 314  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 372

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 373  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 429

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 430  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 484

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 485  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 543

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 544  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 602

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 603  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 659

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 660  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 716

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 717  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 773

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 774  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 833

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 834  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 893

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 894  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 950

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 951  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1010

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1011 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1066

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1067 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121



 Score =  283 bits (723), Expect = 2e-75
 Identities = 256/891 (28%), Positives = 412/891 (46%), Gaps = 106/891 (11%)

Query: 210  EGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV---TTAEELDRETKSTHVFRVTAQDHGM 266
            +G AG  + T++       + +  +DPV   +   +T   LDR+    ++  +  Q   +
Sbjct: 41   KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPM-NIHSIVVQVQCI 99

Query: 267  PRRSALAT---LTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLT-----VRATDGDA 318
             ++        + I+V D ND+ P F+ + Y  ++ E   VG  + T       ATD D 
Sbjct: 100  NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDD 159

Query: 319  PPNANILYRLLEGSGGSP--SEVFEID-PRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
             PN  I Y +++ +   P  ++ FEI    +G I  R  ++ E+   Y + ++A+D+ ++
Sbjct: 160  GPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218

Query: 376  PGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR-----------------EDVTPGAP 417
                R+TT  + + V D +D  P F     V   R                 E++ P   
Sbjct: 219  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278

Query: 418  VLRVTASDRDK-----GSNAVVHYSIMSGNARGQ---FYLDAQTGALDVVSPLDYETTKE 469
               + A D+D+          + YSI+ G        F++  +T  L ++ P++ +  ++
Sbjct: 279  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338

Query: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV----- 524
            + L ++A+     PL   +GL  +++LD N+ +P F    +Q  +LES P+G  +     
Sbjct: 339  FDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397

Query: 525  ----LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TGWISVAAELDREEVDFYSF 578
                L + A+D D  D    E  L    +   FT+     T ++++   +DREE   Y+F
Sbjct: 398  LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457

Query: 579  GVEARD---HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAV 635
             + A D      P +     V++ V+D NDN PTF +  Y V +  D   G SV+ ++AV
Sbjct: 458  SITAFDGVQESEPVI-----VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 512

Query: 636  DRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT-- 691
            D D  ++  ITY+I  G  +  F I   +  GL+++A  ++  + R Y L V A+D    
Sbjct: 513  DADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAPP 569

Query: 692  ---RQDTAQIVVNVTDANTHRPV-FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARI 747
               R     + + V   N   P  F    Y++ ++E    G  ++ + ATD    E   I
Sbjct: 570  AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSI 626

Query: 748  TYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            TY +E+  PQ  F +   TG +T    LD E    Y L ITA D G P  + T  + I+V
Sbjct: 627  TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVV 685

Query: 806  NDVNDNAPQFLRDSY----QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
             DVNDNAP F  D Y       V E+   F  V Q+ ATD D+G+NG+V Y+      G+
Sbjct: 686  TDVNDNAPVF--DPYLPRNLSVVEEEANAF--VGQVKATDPDAGINGQVHYSL-----GN 736

Query: 862  GDFIVESTS-GIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV 920
             + +   TS G + T  +L+RE    Y L   A D  + P  + + + + VLD++DN PV
Sbjct: 737  FNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 796

Query: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
            F    + V VEEN P G  + ++ A D D G N  + Y+I    +   F L  F+GEL+ 
Sbjct: 797  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854

Query: 981  LVDLDYEDRPEY---------VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
            L  LDYE  P+             I  T  P ++  TV V+  D ND PPV
Sbjct: 855  LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPV 903



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 231  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 291  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 351  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 410  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 470  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 530  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 588

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 589  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 644

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 645  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 703

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 704  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 757

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 758  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 812

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 813  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 230  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 290  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 350  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 409  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 464

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 465  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 524  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 583  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 638

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 639  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 687



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 110  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 170  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 230  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 290  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 350  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 410  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 470  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 525

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 526  ILVGAQGDFI-INKTTGLITIAPGVE 550


>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
          Length = 1952

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLD 1096



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 910  ATVTVIVK--DMNDYPPV 925



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 394

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 451

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 506

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 565

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 625  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 738

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 739  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 795

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 972

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 973  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1088

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572


>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
          Length = 1957

 Score =  293 bits (750), Expect = 2e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196

Query: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256

Query: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316

Query: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376

Query: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434

Query: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490

Query: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549

Query: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609

Query: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667

Query: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725

Query: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784

Query: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844

Query: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959

Query: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019

Query: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073

Query: 1067 GNELSLVLLNASTGELKLSRALD 1089
            GNE     +N  TG + ++  LD
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLD 1096



 Score =  292 bits (747), Expect = 4e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443

Query: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501

Query: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557

Query: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617

Query: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674

Query: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788

Query: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848

Query: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906

Query: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966

Query: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026

Query: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080

Query: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254



 Score =  285 bits (730), Expect = 4e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95

Query: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154

Query: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213

Query: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333

Query: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392

Query: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452

Query: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507

Query: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564

Query: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736

Query: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791

Query: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851

Query: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909

Query: 1005 SRATVHVRLLDRNDNPPV 1022
            +  TV V+  D ND PPV
Sbjct: 910  ATVTVIVK--DMNDYPPV 925



 Score =  283 bits (724), Expect = 2e-75
 Identities = 265/895 (29%), Positives = 403/895 (45%), Gaps = 83/895 (9%)

Query: 182  QPPSYQATVPE-------NQPAGTPVASLRAIDPDEG-----EAGRLEYTMDALFDSRSN 229
            +P +YQA +PE       N    TP   ++AID D       +   + Y++         
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTP--PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335

Query: 230  QFFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPV 288
            +FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P 
Sbjct: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPY 394

Query: 289  FEQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEV 339
            F    Y+  + E+  VG  +         L + A D D     +    L      S   V
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---V 451

Query: 340  FEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
            F +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN 
Sbjct: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNT 506

Query: 397  PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
            P F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG +
Sbjct: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 565

Query: 457  DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQAT 513
             +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624

Query: 514  VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
            + E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  
Sbjct: 625  ISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDREST 681

Query: 574  DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVT 631
            D Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  
Sbjct: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQ 738

Query: 632  VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT 691
            V A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG 
Sbjct: 739  VKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGA 795

Query: 692  ---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARIT 748
               R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N    
Sbjct: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855

Query: 749  YFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEIL 804
                +    F +   TG ++    LDYE     + S T  + A D           + ++
Sbjct: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915

Query: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD- 861
            V D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD   
Sbjct: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQF 972

Query: 862  ----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
                  F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + 
Sbjct: 973  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032

Query: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
            P   +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G 
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGV 1088

Query: 978  LTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
            +     LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143



 Score =  231 bits (588), Expect = 1e-59
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372

Query: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551

Query: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610

Query: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666

Query: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725

Query: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779

Query: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834

Query: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881



 Score =  140 bits (354), Expect = 1e-32
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430

Query: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545

Query: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604

Query: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660

Query: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251

Query: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311

Query: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371

Query: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431

Query: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491

Query: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
               G +   + +N +TG + ++  ++
Sbjct: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130,045,549
Number of Sequences: 37866
Number of extensions: 7181440
Number of successful extensions: 56471
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 480
Number of HSP's successfully gapped in prelim test: 524
Number of HSP's that attempted gapping in prelim test: 29810
Number of HSP's gapped (non-prelim): 9886
length of query: 2923
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2803
effective length of database: 13,703,598
effective search space: 38411185194
effective search space used: 38411185194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.