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Search of human proteins with 4557679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557679 jagged 1 precursor [Homo sapiens]
(1218 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557679 jagged 1 precursor [Homo sapiens] 2724 0.0
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 1457 0.0
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 1165 0.0
gi|148833508 notch1 preproprotein [Homo sapiens] 550 e-156
gi|24041035 notch 2 preproprotein [Homo sapiens] 524 e-148
gi|134244285 Notch homolog 3 [Homo sapiens] 523 e-148
gi|55770876 notch4 preproprotein [Homo sapiens] 494 e-139
gi|110735443 delta-like 1 [Homo sapiens] 490 e-138
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 474 e-133
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 418 e-116
gi|122937283 6720455I24Rik homolog [Homo sapiens] 390 e-108
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 293 9e-79
gi|112420992 crumbs homolog 2 [Homo sapiens] 281 3e-75
gi|148886654 polydom [Homo sapiens] 248 3e-65
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 241 4e-63
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 234 5e-61
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens] 233 8e-61
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 225 2e-58
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 225 2e-58
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 225 2e-58
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 221 4e-57
gi|153946395 tenascin C precursor [Homo sapiens] 220 6e-57
gi|24430141 fibrillin 1 precursor [Homo sapiens] 219 2e-56
gi|56237021 fibrillin 3 precursor [Homo sapiens] 217 6e-56
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 213 7e-55
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 213 9e-55
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 213 9e-55
gi|188528675 slit homolog 1 [Homo sapiens] 212 2e-54
gi|66346695 fibrillin 2 precursor [Homo sapiens] 207 6e-53
gi|74136023 delta-like 1 homolog [Homo sapiens] 203 9e-52
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 2724 bits (7062), Expect = 0.0
Identities = 1218/1218 (100%), Positives = 1218/1218 (100%)
Query: 1 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN 60
MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN
Sbjct: 1 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN 60
Query: 61 PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRI 120
PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRI
Sbjct: 61 PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRI 120
Query: 121 VLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE 180
VLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE
Sbjct: 121 VLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE 180
Query: 181 YQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSP 240
YQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSP
Sbjct: 181 YQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSP 240
Query: 241 KHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYC 300
KHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYC
Sbjct: 241 KHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYC 300
Query: 301 GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC 360
GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC
Sbjct: 301 GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC 360
Query: 361 ECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP 420
ECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP
Sbjct: 361 ECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP 420
Query: 421 CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYA 480
CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYA
Sbjct: 421 CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYA 480
Query: 481 GDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC 540
GDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC
Sbjct: 481 GDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC 540
Query: 541 YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600
YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG
Sbjct: 541 YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600
Query: 601 PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWE 660
PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWE
Sbjct: 601 PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWE 660
Query: 661 GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTC 720
GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTC
Sbjct: 661 GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTC 720
Query: 721 YDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICA 780
YDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICA
Sbjct: 721 YDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICA 780
Query: 781 QNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEIN 840
QNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEIN
Sbjct: 781 QNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEIN 840
Query: 841 GYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR 900
GYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR
Sbjct: 841 GYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR 900
Query: 901 PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCAN 960
PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCAN
Sbjct: 901 PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCAN 960
Query: 961 ITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAED 1020
ITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAED
Sbjct: 961 ITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAED 1020
Query: 1021 IRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVA 1080
IRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVA
Sbjct: 1021 IRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVA 1080
Query: 1081 WICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYE 1140
WICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYE
Sbjct: 1081 WICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYE 1140
Query: 1141 NKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQ 1200
NKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQ
Sbjct: 1141 NKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQ 1200
Query: 1201 DNRDLESAQSLNRMEYIV 1218
DNRDLESAQSLNRMEYIV
Sbjct: 1201 DNRDLESAQSLNRMEYIV 1218
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 1457 bits (3771), Expect = 0.0
Identities = 665/1249 (53%), Positives = 844/1249 (67%), Gaps = 53/1249 (4%)
Query: 5 RTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGG-ARNPGD 63
R +GR P LLL L AL + G FEL++ +++NVNGEL +G CC G R
Sbjct: 2 RAQGRGRLPRRLLLLL--ALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRA 59
Query: 64 RKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLK-ASRGNDRNR--- 119
C DECDTY +VCLKEYQ++VT GPCS+G G+TPV+GGN+F L A DR R
Sbjct: 60 GGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARA 119
Query: 120 ----------IVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSI-IEKASHSGMINPSRQWQ 168
+V+PF FAWPRS+TL+VEAWD NDT + + IE+ SH+GMINP +W+
Sbjct: 120 RAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWK 179
Query: 169 TLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPE 228
+L + VAH E QIRV CD+ YY CNKFCRPR+DFFGHY CDQ GNK CM+GWMG E
Sbjct: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKE 239
Query: 229 CNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNW 288
C A+C+QGC+ HG C +PG+CRC YGWQG +CD+C+P+PGCVHG C EPWQC CETNW
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNW 299
Query: 289 GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNR 348
GG LCDKDLNYCG+H PC NGGTC N PD+Y+C+CP+GYSG NCE AEHAC S+PC N
Sbjct: 300 GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG 359
Query: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKT 408
GSC E GFEC C GW+GPTC+ +ID+C+ N C+ GGTC D V+GF+C+CP QW G T
Sbjct: 360 GSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGAT 419
Query: 409 CQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLV 468
CQLDANECE KPC+NA SCKNLI YYCDC+PGW G NC IN+NDC GQCQ+ +C+DLV
Sbjct: 420 CQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLV 479
Query: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY 528
NGY+C+CP G+ G HCE + DECAS+PC +GG C++ + F C CP GFSG LC++D+D
Sbjct: 480 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 539
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
CEP+PC+NGA+CYN DY+C CP+D+ GKNCS ++ C C VID C S+ P
Sbjct: 540 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC----GSDAGP 595
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
+S VCGPHG+C SQ GG F+C C+ GFTGTYCHENI+DC PCRNGGTCID V
Sbjct: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEV 655
Query: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
++++C C GWEG C+TN NDC +PCH+ G C DLVNDFYC C +GWKGKTCHSR+ Q
Sbjct: 656 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 715
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTC 768
CD TC+NGGTCYD GD F+C CP GW+G+TC +A+NSSCLPNPC NGGTCV +G SF+C
Sbjct: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
Query: 769 VCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP 828
+C++GWEG C NTNDC+P PCYN G CVDG NW+RCECAPGFAGPDCRINI+ECQSSP
Sbjct: 776 ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 835
Query: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGRPCITMGSVIPDGAKWDDDCNTCQCL 886
CA+GATCVDEINGYRC CPPG +G +CQEV GR C + G+ P G+ W +DCN+C+CL
Sbjct: 836 CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
Query: 887 NGRIACSKVWCGPRPCLL----HKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQ 942
+GR CSKVWCG +PCLL ++CP GQ C+ QC PC GEC + +
Sbjct: 896 DGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAE--E 953
Query: 943 PVKTKCTSDSYYQD-NCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIA 1001
P T C S + D NCA +T FN++ + G T ICS +R+L + V+ + + +
Sbjct: 954 PPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLL 1013
Query: 1002 CEPSPSANNEIHVAISAEDIRD--DGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQR 1059
C+ + S + + VA+S RD D + I+ I+ +++R GNSSL+ AV EV+V+
Sbjct: 1014 CDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQR-GNSSLLLAVTEVKVET 1072
Query: 1060 RPL-KNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQ 1118
+ T LVP+L +V W+ C+V +W RKRRK + E+ + NN
Sbjct: 1073 VVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWW-TRKRRKERERSRLPREE-SANNQWAP 1130
Query: 1119 LNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTH--------NSEVEEDDMDKHQQKARF 1170
LN I+NPIE+ G + + Y+ KN R ++ V ED+ D+ +
Sbjct: 1131 LNPIRNPIERPGGHKDVL--YQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEE 1188
Query: 1171 AKQPAYTLVDRE-EKPPNGTPTKHPNWTN--KQDNRDLESAQSLNRMEY 1216
A + + K P +P + +W + K DNR + +S+N Y
Sbjct: 1189 DSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNR---AVRSINEARY 1234
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 1165 bits (3014), Expect = 0.0
Identities = 568/1253 (45%), Positives = 759/1253 (60%), Gaps = 99/1253 (7%)
Query: 5 RTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGG-ARNPGD 63
R +GR P LLL L AL + G FEL++ +++NVNGEL +G CC G R
Sbjct: 2 RAQGRGRLPRRLLLLL--ALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRA 59
Query: 64 RKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLK-ASRGNDRNR--- 119
C DECDTY +VCLKEYQ++VT GPCS+G G+TPV+GGN+F L A DR R
Sbjct: 60 GGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARA 119
Query: 120 ----------IVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSI-IEKASHSGMINPSRQWQ 168
+V+PF FAWPRS+TL+VEAWD NDT + + IE+ SH+GMINP +W+
Sbjct: 120 RAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWK 179
Query: 169 TLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPE 228
+L + VAH E QIRV CD+ YY CNKFCRPR+DFFGHY
Sbjct: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHY------------------ 221
Query: 229 CNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGC--VHGICNEPWQCLCET 286
+C G+ C GW G C + + GC +HG C P +C C
Sbjct: 222 ---------------TCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 266
Query: 287 NWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSD-PC 345
W G+ CD+ + Y G C++G + +QC+C + G C+ + C S PC
Sbjct: 267 GWQGRFCDECVPYPG----CVHGSCV-----EPWQCNCETNWGGLLCDKDLNYCGSHHPC 317
Query: 346 HNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQW 404
N G+C + C C G++G C C+ N C++GG+C ++ +GF+C CP W
Sbjct: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW 377
Query: 405 TGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASC 464
+G TC LD +EC + PC +C + + + C C W+G C +++NDC GQCQ+ +C
Sbjct: 378 SGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTC 437
Query: 465 RDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQL 524
+DLVNGY+C+CP G+ G HCE + DECAS+PC +GG C++ + F C CP GFSG LC++
Sbjct: 438 KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEV 497
Query: 525 DIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMAS 584
D+D CEP+PC+NGA+CYN DY+C CP+D+ GKNCS ++ C C VID C S
Sbjct: 498 DVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC----GS 553
Query: 585 NDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTC 644
+ P +S VCGPHG+C SQ GG F+C C+ GFTGTYCHENI+DC PCRNGGTC
Sbjct: 554 DAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC 613
Query: 645 IDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS 704
ID V++++C C GWEG C+TN NDC +PCH+ G C DLVNDFYC C +GWKGKTCHS
Sbjct: 614 IDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHS 673
Query: 705 RDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE 764
R+ QCD TC+NGGTCYD GD F+C CP GW+G+TC +A+NSSCLPNPC NGGTCV +G
Sbjct: 674 REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA 733
Query: 765 SFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININEC 824
SF+C+C++GWEG C NTNDC+P PCYN G CVDG NW+RCECAPGFAGPDCRINI+EC
Sbjct: 734 SFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 793
Query: 825 QSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGRPCITMGSVIPDGAKWDDDCNT 882
QSSPCA+GATCVDEINGYRC CPPG +G +CQEV GR C + G+ P G+ W +DCN+
Sbjct: 794 QSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS 853
Query: 883 CQCLNGRIACSKVWCGPRPCLL----HKGHSECPSGQSCIPILDDQCFVHPCTGVGECRS 938
C+CL+GR CSKVWCG +PCLL ++CP GQ C+ QC PC GEC +
Sbjct: 854 CRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 913
Query: 939 SSLQPVKTKCTSDSYYQD-NCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYS 997
+P T C S + D NCA +T FN++ + G T ICS +R+L + V+ +
Sbjct: 914 E--EPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRL 971
Query: 998 IYIACEPSPSANNEIHVAISAEDIRD--DGNPIKEITDKIIDLVSKRDGNSSLIAAVAEV 1055
+ + C+ + S + + VA+S RD D + I+ I+ +++R GNSSL+ AV EV
Sbjct: 972 LVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQR-GNSSLLLAVTEV 1030
Query: 1056 RVQRRPL-KNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNN 1114
+V+ + T LVP+L +V W+ C+V +W RKRRK + E+ + NN
Sbjct: 1031 KVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWW-TRKRRKERERSRLPREE-SANN 1088
Query: 1115 VREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTH--------NSEVEEDDMDKHQQ 1166
LN I+NPIE+ G + + Y+ KN R ++ V ED+ D+
Sbjct: 1089 QWAPLNPIRNPIERPGGHKDVL--YQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLG 1146
Query: 1167 KARFAKQPAYTLVDRE-EKPPNGTPTKHPNWTN--KQDNRDLESAQSLNRMEY 1216
+ A + + K P +P + +W + K DNR + +S+N Y
Sbjct: 1147 RGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNR---AVRSINEARY 1196
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 550 bits (1416), Expect = e-156
Identities = 282/824 (34%), Positives = 406/824 (49%), Gaps = 116/824 (14%)
Query: 220 CMEGWMGPECNRAICRQGCSP-KHGSCKLPGD----CRCQYGWQGLYC----DKCIPHPG 270
C G+ G C + +P K+G+ L G C C G+ G +C D+C P P
Sbjct: 516 CPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDP- 574
Query: 271 CVHGICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEG 327
C +G C + + CLC + G C+ ++N C + QPC +GGTC + + Y C C +G
Sbjct: 575 CHYGSCKDGVATFTCLCRPGYTGHHCETNINECSS-QPCRHGGTCQDRD-NAYLCFCLKG 632
Query: 328 YSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGG 387
+GPNCEI C S PC + G+C + G+EC C PG+TG C+ NID+C+ N C +GG
Sbjct: 633 TTGPNCEINLDDCASSPCDS-GTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGG 691
Query: 388 TCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNC 447
TC+D +NGF C CP + TC + NEC + PCV+ +C++ + Y CDC PGW G NC
Sbjct: 692 TCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHG-ACRDSLNGYKCDCDPGWSGTNC 750
Query: 448 DININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEI 506
DIN N+C C N +C+D+ +GY C C G++G +C+ +I+ECASNPCLN G C +++
Sbjct: 751 DINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV 810
Query: 507 ----------------------------------------NRFQCLCPTGFSGNLCQLDI 526
F C+CPTG+ G C++DI
Sbjct: 811 AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDI 870
Query: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMAS-- 584
+ C +PC++GA C N Y C C Y G+NC D CR PC SCT + +
Sbjct: 871 NECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAF 930
Query: 585 ---------NDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCES 635
E + +S+ C C + +TC C GF+G +C N DC
Sbjct: 931 CDCLPGFRGTFCEEDINECASDPCRNGANC-TDCVDSYTCTCPAGFSGIHCENNTPDCTE 989
Query: 636 NPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKN 695
+ C NGGTC+DG+NS+ C+C G+ G+YC+ ++N+C PC +GGTC+D + C C
Sbjct: 990 SSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQ 1049
Query: 696 GWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNI---------ARNS 746
G+ G C + CD + C NGG C+ ++C CP GW G C++ R
Sbjct: 1050 GYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQG 1109
Query: 747 SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRC 806
+ C +GG CV G + C C+ G+ G C ++CSP PC N TC D Y C
Sbjct: 1110 VDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSC 1169
Query: 807 ECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ---------- 856
+C G+ G +C I+EC S PC G TC+D N Y+C CP G G C+
Sbjct: 1170 KCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPV 1229
Query: 857 -EVSGRP-CITMGSVIPD-------------GAKWDDDCNTCQCLNGRIACSKVWCGPRP 901
VS P C G+ + G + + D N +CL+ G +
Sbjct: 1230 DPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVN--ECLSNPCDAR----GTQN 1283
Query: 902 CL--LHKGHSECPSGQS---CIPILDDQCFVHPCTGVGECRSSS 940
C+ ++ H EC +G + C +++ C PC G C +S
Sbjct: 1284 CVQRVNDFHCECRAGHTGRRCESVING-CKGKPCKNGGTCAVAS 1326
Score = 549 bits (1414), Expect = e-156
Identities = 293/824 (35%), Positives = 401/824 (48%), Gaps = 115/824 (13%)
Query: 210 YACDQNGNKTCMEGWMGPECNRAI--------CRQGCSPKHGSCKL----PGDCRCQYGW 257
YAC +C G+ GP C + CR G G+C L CRC GW
Sbjct: 85 YAC------SCALGFSGPLCLTPLDNACLTNPCRNG-----GTCDLLTLTEYKCRCPPGW 133
Query: 258 QGLYC---DKCIPHPGCVHGIC---NEPWQCLCETNWGGQLCDKDLNYCGTHQP-CLNGG 310
G C D C +P G C + C C ++ G C +D+N CG C +GG
Sbjct: 134 SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGG 193
Query: 311 TCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETS-LGFECECSPGWTGP 369
TC N Y+C C ++GPNCE C PC N G+C+ T + EC C PG+TG
Sbjct: 194 TCHNE-VGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQ 252
Query: 370 TCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP--CVNAKSC 427
C NIDDC NNC +GG C D VN + C CPP+WTG+ C D +EC+ P C N +C
Sbjct: 253 NCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTC 312
Query: 428 KNLIASYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYR-------------- 472
N Y C C+ GW G++C NI+DC C + A+C D V +
Sbjct: 313 HNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHL 372
Query: 473 -------------------------CICPPGYAGDHCERDIDECA--SNPCLNGGHCQNE 505
C CP GY G C +D+DEC+ +NPC + G C N
Sbjct: 373 NDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINT 432
Query: 506 INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKD 565
+ F+C C G++G C++D++ C NPCQN A C ++ ++ C C YEG +C D
Sbjct: 433 LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTD 492
Query: 566 HCRTTPC-----------EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFT 614
C ++PC E C + V +S C KC +T
Sbjct: 493 ECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKC-LDGPNTYT 551
Query: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN 674
C C +G+TGT+C +I++C+ +PC + G+C DGV ++ C+C G+ G +CETNIN+CS
Sbjct: 552 CVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQ 610
Query: 675 PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGG 734
PC +GGTC+D N + C C G G C C + C++ GTC D+ D ++C C G
Sbjct: 611 PCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDS-GTCLDKIDGYECACEPG 669
Query: 735 WEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNS 794
+ G+ CNI C NPCHNGGTC FTC C EG+ P C N+C+ +PC +
Sbjct: 670 YTGSMCNI-NIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVH- 727
Query: 795 GTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAK 854
G C D N Y+C+C PG++G +C IN NEC+S+PC G TC D +GY C C G SG
Sbjct: 728 GACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPN 787
Query: 855 CQ----EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVW--CGPRPCL----- 903
CQ E + PC+ G+ I D A + CN G C V C P PC
Sbjct: 788 CQTNINECASNPCLNQGTCIDDVAGY--KCNCLLPYTG-ATCEVVLAPCAPSPCRNGGEC 844
Query: 904 -----LHKGHSECPS---GQSCIPILDDQCFVHPCTGVGECRSS 939
CP+ GQ+C + ++C + PC C+++
Sbjct: 845 RQSEDYESFSCVCPTGWQGQTC-EVDINECVLSPCRHGASCQNT 887
Score = 545 bits (1405), Expect = e-155
Identities = 277/781 (35%), Positives = 396/781 (50%), Gaps = 60/781 (7%)
Query: 217 NKTCMEGWMGPECNRAI--CRQGCSPKHGSCK---LPGDCRCQYGWQGLYC---DKCIPH 268
N C+ GW G +C+ I C +C C C +G GL C D CI +
Sbjct: 320 NCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISN 379
Query: 269 P-----GCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTH-QPCLNGGTCSNTGPDKYQC 322
P C N C C + + G C +D++ C PC + G C NT ++C
Sbjct: 380 PCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINT-LGSFEC 438
Query: 323 SCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN 382
C +GY+GP CEI + C+S+PC N +C + F+C C PG+ G C N D+C+ +
Sbjct: 439 QCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSP 498
Query: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGW 442
C H G C D +N F+C CP +TG CQ D +EC + PC N C + +Y C C G+
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY 558
Query: 443 MGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHC 502
G +C+++I++C + SC+D V + C+C PGY G HCE +I+EC+S PC +GG C
Sbjct: 559 TGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTC 618
Query: 503 QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSH 562
Q+ N + C C G +G C++++D C +PC +G C ++ Y C C Y G C+
Sbjct: 619 QDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGYTGSMCNI 677
Query: 563 LKDHCRTTPCEVIDSCT--VAMASNDTPEG---------VRYISSNVCGPHGKCKSQSGG 611
D C PC +C + + PEG V +SN C HG C+ G
Sbjct: 678 NIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPC-VHGACRDSLNG 736
Query: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDC 671
+ CDC+ G++GT C N N+CESNPC NGGTC D + Y C C +G+ G C+TNIN+C
Sbjct: 737 -YKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINEC 795
Query: 672 SQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD--AFKC 729
+ NPC N GTC D V + C+C + G TC + C + C NGG C D +F C
Sbjct: 796 ASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSC 855
Query: 730 MCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPH 789
+CP GW+G TC + N C+ +PC +G +C + C C+ G+ G C + +DC P+
Sbjct: 856 VCPTGWQGQTCEVDIN-ECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPN 914
Query: 790 PCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPG 849
PC+N G+C DG N C+C PGF G C +INEC S PC GA C D ++ Y C CP G
Sbjct: 915 PCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAG 974
Query: 850 HSGAKCQ----EVSGRPCITMGSVIP-------------DGAKWDDDCNTCQ---CLNGR 889
SG C+ + + C G+ + G+ D N C CL+G
Sbjct: 975 FSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHG- 1033
Query: 890 IACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCT 949
+ CG C +G+ +G +C ++ C PC G+C + Q + +C
Sbjct: 1034 -GTCQDGCGSYRCTCPQGY----TGPNCQNLV-HWCDSSPCKNGGKCWQTHTQ-YRCECP 1086
Query: 950 S 950
S
Sbjct: 1087 S 1087
Score = 536 bits (1382), Expect = e-152
Identities = 287/836 (34%), Positives = 412/836 (49%), Gaps = 83/836 (9%)
Query: 238 CSPKHGSCKLPGDCRCQYGWQGLYC------------DKCIPHPGCVHGICN-------E 278
CS +C G C G + C + C+ P G C+
Sbjct: 24 CSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVA 83
Query: 279 PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEH 338
+ C C + G LC L+ PC NGGTC +Y+C CP G+SG +C+ A+
Sbjct: 84 DYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQAD- 142
Query: 339 ACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDC--SPNNCSHGGTCQDLVNGF 396
C S+PC N G C + C C P + GPTC ++++C P C HGGTC + V +
Sbjct: 143 PCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSY 202
Query: 397 KCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNL-IASYYCDCLPGWMGQNCDININDCL 455
+CVC TG C+ C PC N +C+ ++ C CLPG+ GQNC+ NI+DC
Sbjct: 203 RCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCP 262
Query: 456 G-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDEC--ASNPCLNGGHCQNEINRFQCL 512
G C+N +C D VN Y C CPP + G +C D+DEC N C NGG C N + C+
Sbjct: 263 GNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCV 322
Query: 513 CPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC 572
C G++G C +ID C C +GA C++R + ++C+CP G C HL D C + PC
Sbjct: 323 CVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLC-HLNDACISNPC 381
Query: 573 EVIDSC-----------------TVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTC 615
+C T S D E + +N C GKC + G F C
Sbjct: 382 NEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDE--CSLGANPCEHAGKC-INTLGSFEC 438
Query: 616 DCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNP 675
C +G+TG C ++N+C SNPC+N TC+D + ++CIC G+EG +CE N ++C+ +P
Sbjct: 439 QCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSP 498
Query: 676 CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW 735
C + G C D +N+F C+C G+ G C +C C NG C D + + C+C G+
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY 558
Query: 736 EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSG 795
GT C + + C P+PCH G+C +FTC+C+ G+ G C N N+CS PC + G
Sbjct: 559 TGTHCEVDID-ECDPDPCHY-GSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGG 616
Query: 796 TCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC 855
TC D DN Y C C G GP+C IN+++C SSPC G TC+D+I+GY C C PG++G+ C
Sbjct: 617 TCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSG-TCLDKIDGYECACEPGYTGSMC 675
Query: 856 ----QEVSGRPCITMGSVIPDGAKWDDDCN--TCQCLNG---RIACSKV-WCGPRPCL-- 903
E +G PC +G +D N TC+C G S+V C PC+
Sbjct: 676 NINIDECAGNPC-------HNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHG 728
Query: 904 -----LHKGHSECP---SGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQ 955
L+ +C SG +C I +++C +PC G C+ + V T + +
Sbjct: 729 ACRDSLNGYKCDCDPGWSGTNC-DINNNECESNPCVNGGTCKDMTSGYVCT--CREGFSG 785
Query: 956 DNC-ANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIA-CEPSPSAN 1009
NC NI + ++ G + + N +L A + +A C PSP N
Sbjct: 786 PNCQTNINECASNPCLNQGTCIDDVAGYKCNC-LLPYTGATCEVVLAPCAPSPCRN 840
Score = 501 bits (1289), Expect = e-141
Identities = 255/731 (34%), Positives = 352/731 (48%), Gaps = 90/731 (12%)
Query: 220 CMEGWMGPECNRAICRQGCSPKH--GSCK--LPG-DCRCQYGWQGLYC----DKCIPHPG 270
C G+ G CN I +P H G+C+ + G CRC G+ C ++C +P
Sbjct: 666 CEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNP- 724
Query: 271 CVHGICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEG 327
CVHG C + ++C C+ W G CD + N C ++ PC+NGGTC + Y C+C EG
Sbjct: 725 CVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESN-PCVNGGTCKDM-TSGYVCTCREG 782
Query: 328 YSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGG 387
+SGPNC+ + C S+PC N+G+C + G++C C +TG TC + C+P+ C +GG
Sbjct: 783 FSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGG 842
Query: 388 TCQDLVN--GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY----------- 434
C+ + F CVCP W G+TC++D NEC PC + SC+N Y
Sbjct: 843 ECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGR 902
Query: 435 ---------------------------YCDCLPGWMGQNCDININDCLGQ-CQNDASCRD 466
+CDCLPG+ G C+ +IN+C C+N A+C D
Sbjct: 903 NCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTD 962
Query: 467 LVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDI 526
V+ Y C CP G++G HCE + +C + C NGG C + IN F CLCP GF+G+ CQ D+
Sbjct: 963 CVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDV 1022
Query: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC--TVAMAS 584
+ C+ PC +G C + Y C CP+ Y G NC +L C ++PC+ C T
Sbjct: 1023 NECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYR 1082
Query: 585 NDTPEG-------VRYISSNVCGP-----------HGKCKSQSGGKFTCDCNKGFTGTYC 626
+ P G V +S V HG +G C C G+TG+YC
Sbjct: 1083 CECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYC 1142
Query: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 686
+ +++C +PC+NG TC D + Y C C G+ G C I++C +PC NGGTC DL
Sbjct: 1143 EDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLP 1202
Query: 687 NDFYCDCKNGWKGKTCHSRDSQCDEAT--------CNNGGTCYDEGDAFKCMCPGGWEGT 738
N + C C G +G C C+ C N GTC D+ + C CP G+ G
Sbjct: 1203 NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE 1262
Query: 739 TCNIARNSSCLPNPCHNGGT--CVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGT 796
C N CL NPC GT CV F C C+ G G C N C PC N GT
Sbjct: 1263 RCEGDVNE-CLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGT 1321
Query: 797 CVDGDNWYR---CECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGA 853
C N R C+C GF G C + C S C G TC+ C+C +G
Sbjct: 1322 CAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGP 1381
Query: 854 KCQEVSGRPCI 864
+CQ + PC+
Sbjct: 1382 ECQFPASSPCL 1392
Score = 346 bits (887), Expect = 9e-95
Identities = 224/725 (30%), Positives = 302/725 (41%), Gaps = 134/725 (18%)
Query: 184 RVTCDDYYYGFGCNKF---CRPRDDFFGHYACDQNGNKT---CMEGWMGPECNRAI---- 233
R C Y G C CRP G +C N C+ G+ G C I
Sbjct: 892 RCHCQAGYSGRNCETDIDDCRPNPCHNGG-SCTDGINTAFCDCLPGFRGTFCEEDINECA 950
Query: 234 ---CRQGCSPKHGSCKLPGDCRCQYGWQGLYCDK---------CIPHPGCVHGICNEPWQ 281
CR G + C C C G+ G++C+ C CV GI +
Sbjct: 951 SDPCRNGANCT--DCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGI--NSFT 1006
Query: 282 CLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL 341
CLC + G C D+N C + QPCL+GGTC + G Y+C+CP+GY+GPNC+ H C
Sbjct: 1007 CLCPPGFTGSYCQHDVNECDS-QPCLHGGTCQD-GCGSYRCTCPQGYTGPNCQNLVHWCD 1064
Query: 342 SDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCS----------PNNCSHGGTCQD 391
S PC N G C +T + CEC GWTG C C C HGG C D
Sbjct: 1065 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVD 1124
Query: 392 LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDINI 451
N C C +TG C+ +EC PC N +C + + Y C C+ G+ G NC I
Sbjct: 1125 AGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEI 1184
Query: 452 NDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDEC--------ASNPCLNGGHC 502
++CL CQN +C DL N Y+C CP G G HCE ++D+C S C N G C
Sbjct: 1185 DECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTC 1244
Query: 503 QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQ-NGAQ-CYNRASDYFCKCPEDYEGKNC 560
+++ + C CP GF G C+ D++ C NPC G Q C R +D+ C+C + G+ C
Sbjct: 1245 VDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRC 1304
Query: 561 SHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKG 620
+ + C+ PC+ +C VA S + F C C G
Sbjct: 1305 ESVINGCKGKPCKNGGTCAVA-------------------------SNTARGFICKCPAG 1339
Query: 621 FTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIND--CSQNPCHN 678
F G C + C S C NGGTCI G S C+C + G C+ + NPC+N
Sbjct: 1340 FEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYN 1399
Query: 679 GGTCRDL-VNDFY-CDCKNGWKGKTCHSRD----------------------SQCDE--- 711
GTC + FY C C + G CH D +C E
Sbjct: 1400 QGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAG 1459
Query: 712 -----ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSC--------LPNPCHNGGT 758
CNN +D GD C + N ++ C + C++ G
Sbjct: 1460 NKVCSLQCNNHACGWDGGD-----CSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAG- 1513
Query: 759 CVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCR 818
C+ +G F C EG P+ Q C H ++ G C G N CE + G DC
Sbjct: 1514 CLFDG--FDCQRAEGQCNPLYDQY---CKDH--FSDGHCDQGCNSAECE----WDGLDCA 1562
Query: 819 ININE 823
++ E
Sbjct: 1563 EHVPE 1567
Score = 128 bits (322), Expect = 3e-29
Identities = 74/235 (31%), Positives = 98/235 (41%), Gaps = 55/235 (23%)
Query: 704 SRDSQCDEA--TCNNGGTCYDEGDAFKCMCPG---------------------------- 733
+R +C + TC NGG C C+C G
Sbjct: 19 ARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVD 78
Query: 734 -------------GWEGTTCNIARNSSCLPNPCHNGGTC-VVNGESFTCVCKEGWEGPIC 779
G+ G C +++CL NPC NGGTC ++ + C C GW G C
Sbjct: 79 RRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSC 138
Query: 780 AQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP--CAFGATCVD 837
Q + C+ +PC N G C+ + Y C C P F GP CR ++NEC P C G TC +
Sbjct: 139 -QQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHN 197
Query: 838 EINGYRCVCPPGHSGAKCQE----VSGRPCITMGSVIPDGAKWDDDCNTCQCLNG 888
E+ YRCVC H+G C+ S PC G+ P G D + C CL G
Sbjct: 198 EVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG----DVTHECACLPG 248
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 524 bits (1349), Expect = e-148
Identities = 296/873 (33%), Positives = 406/873 (46%), Gaps = 142/873 (16%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYA-----CDQN--------------GNKTCM--EGWM 225
C Y+ G G +C+ + F G Y C++N G TC G+
Sbjct: 41 CVTYHNGTG---YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFT 97
Query: 226 GPECNRAI---------CRQGCSPKHGSCKLPG----DCRCQYGWQGLYC---DKCIPHP 269
G +C + C G G+C + +C CQ G+ G C D C+ HP
Sbjct: 98 GEDCQYSTSHPCFVSRPCLNG-----GTCHMLSRDTYECTCQVGFTGKECQWTDACLSHP 152
Query: 270 GCVHG-----ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSC 324
C +G + N+ + C C T + GQ C+ D+N C C +GGTC N P YQC C
Sbjct: 153 -CANGSTCTTVANQ-FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL-PGSYQCQC 209
Query: 325 PEGYSGPNCEIAEHACLSDPCHNRGSCKETS-LGFECECSPGWTGPTCSTNIDDCSPNNC 383
P+G++G C+ C PC N G+C++T FEC C PG+ G TC NIDDC + C
Sbjct: 210 PQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRC 269
Query: 384 SHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP--CVNAKSCKNLIASYYCDCLPG 441
+GG C D VN + C CPPQWTG+ C D +EC +P C N +C N Y C C+ G
Sbjct: 270 QNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNG 329
Query: 442 WMGQNCDININDC-LGQCQNDASCRDLV-------------------------------- 468
W G +C NI+DC C ++C D V
Sbjct: 330 WSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGAL 389
Query: 469 ------NG-YRCICPPGYAGDHCERDIDECA---SNPCLNGGHCQNEINRFQCLCPTGFS 518
NG Y C CP GY G C D+DECA SNPC + G C N F C C G++
Sbjct: 390 CDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA 449
Query: 519 GNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC----EV 574
G C++DI+ C +PCQN A C ++ + C C ++G +C + C++ PC +
Sbjct: 450 GPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQC 509
Query: 575 IDS-------CTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
+D C + SS C KC G + C C GFTG C
Sbjct: 510 VDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNG-YECQCATGFTGVLCE 568
Query: 628 ENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVN 687
ENI++C+ +PC + G C DG++SY CIC+ G+ GA C I++C +PC N G C DLVN
Sbjct: 569 ENIDNCDPDPCHH-GQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVN 627
Query: 688 DFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSS 747
+ C+C+ G G C C C + G C D + + C+C G+ G CNI +
Sbjct: 628 GYQCNCQPGTSGVNCEINFDDCASNPCIH-GICMDGINRYSCVCSPGFTGQRCNIDID-E 685
Query: 748 CLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCE 807
C NPC G TC+ F C+C EG P C N+C +PC + G C G + Y+C
Sbjct: 686 CASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIH-GNCTGGLSGYKCL 744
Query: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ----EVSGRPC 863
C G+ G +C ++ NEC S+PC G TC + +NGYRC C G G CQ E + PC
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPC 804
Query: 864 ITMGSVIPDGAKWDDDCNTCQCL---NGRIACSKVW--CGPRPCLLHKGHSECPSGQS-- 916
+ G+ D + + TC C+ G+ C V C P PC E P+ +S
Sbjct: 805 LNQGTCFDDISGY-----TCHCVLPYTGK-NCQTVLAPCSPNPCENAAVCKESPNFESYT 858
Query: 917 --CIP--------ILDDQCFVHPCTGVGECRSS 939
C P I D+C PC G C ++
Sbjct: 859 CLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT 891
Score = 515 bits (1326), Expect = e-145
Identities = 272/787 (34%), Positives = 372/787 (47%), Gaps = 94/787 (11%)
Query: 208 GHYACDQNGNKTCMEGWMGPECNRAI---CRQGCSPKHGSCKLPG----DCRCQYGWQGL 260
G Y C C+ GW G +C+ I C+P GS + C C G GL
Sbjct: 320 GGYGC------VCVNGWSGDDCSENIDDCAFASCTP--GSTCIDRVASFSCMCPEGKAGL 371
Query: 261 YC---DKCIPHPGCVHGIC-----NEPWQCLCETNWGGQLCDKDLNYCG--THQPCLNGG 310
C D CI +P +C N + C C + G C +D++ C PC + G
Sbjct: 372 LCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAG 431
Query: 311 TCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPT 370
C NT + C C +GY+GP CE+ + C SDPC N +C + GF C C PG+ G
Sbjct: 432 KCVNTD-GAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Query: 371 CSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNL 430
C I++C N C + G C D VN F+C+CPP +TG CQ+D ++C + PC+N C +
Sbjct: 491 CELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDH 550
Query: 431 IASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490
Y C C G+ G C+ NI++C + C+D ++ Y CIC PGY G C IDE
Sbjct: 551 PNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDE 610
Query: 491 CASNPCLNGGH-------------------------------------CQNEINRFQCLC 513
C S+PCLN G C + INR+ C+C
Sbjct: 611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVC 670
Query: 514 PTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCE 573
GF+G C +DID C NPC+ GA C N + + C CPE +C + C + PC
Sbjct: 671 SPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPC- 729
Query: 574 VIDSCTVAMASNDTPEGVRYIS-----------SNVCGPHGKCKSQSGGKFTCDCNKGFT 622
+ +CT ++ ++ SN C G C + G + C C KGF
Sbjct: 730 IHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNG-YRCTCKKGFK 788
Query: 623 GTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC 682
G C NI++C SNPC N GTC D ++ Y C C + G C+T + CS NPC N C
Sbjct: 789 GYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVC 848
Query: 683 RDLVN--DFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC 740
++ N + C C GW+G+ C +C C N G C++ ++ C CP G+ G C
Sbjct: 849 KESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDC 908
Query: 741 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG 800
CL NPC NGG+C+ +F+C+C G+ G C + N+C PC N GTC D
Sbjct: 909 E-EDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDY 967
Query: 801 DNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC----Q 856
N Y C+C GF G C NINEC S C G TCVD IN + C+CP G +G+ C
Sbjct: 968 VNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEIN 1027
Query: 857 EVSGRPCITMGSVIPDGAKWDDDC------NTCQCLNGRIACSKVWCGPR-PCLLHKGHS 909
E S PC+ G+ + + C CQ L CS+ C + C+ K S
Sbjct: 1028 ECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVN--LCSRSPCKNKGTCVQKKAES 1085
Query: 910 E--CPSG 914
+ CPSG
Sbjct: 1086 QCLCPSG 1092
Score = 495 bits (1275), Expect = e-140
Identities = 287/885 (32%), Positives = 401/885 (45%), Gaps = 127/885 (14%)
Query: 187 CDDYYYGFGCNKFCRPR----------DDFFG----HYACDQNGNK---TCMEGWMGPEC 229
C D G+ CN C+P DD H C N+ C G+ G C
Sbjct: 622 CIDLVNGYQCN--CQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRC 679
Query: 230 NRAI-------CRQGCSPKHGSCKLPGDCRCQYGWQGLYC----DKCIPHPGCVHGICN- 277
N I CR+G + +G C C G C ++C+ +P C+HG C
Sbjct: 680 NIDIDECASNPCRKGATCINGVNGFR--CICPEGPHHPSCYSQVNECLSNP-CIHGNCTG 736
Query: 278 --EPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
++CLC+ W G C+ D N C ++ PC NGGTC N + Y+C+C +G+ G NC++
Sbjct: 737 GLSGYKCLCDAGWVGINCEVDKNECLSN-PCQNGGTCDNL-VNGYRCTCKKGFKGYNCQV 794
Query: 336 AEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN- 394
C S+PC N+G+C + G+ C C +TG C T + CSPN C + C++ N
Sbjct: 795 NIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNF 854
Query: 395 -GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD 453
+ C+C P W G+ C +D +EC +KPC+N C N SY C+C PG+ G +C+ +I+D
Sbjct: 855 ESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDD 914
Query: 454 CLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG------------ 500
CL CQN SC D VN + C+C PG+ GD C+ D++EC S PC NGG
Sbjct: 915 CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCK 974
Query: 501 --------HCQNEINR------------------FQCLCPTGFSGNLCQLDIDYCEPNPC 534
HC+N IN F CLCP GF+G+ C +I+ C +PC
Sbjct: 975 CQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPC 1034
Query: 535 QNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDT--PEG-- 590
N C + Y C CP Y GKNC L + C +PC+ +C A + P G
Sbjct: 1035 LNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWA 1094
Query: 591 -----VRYISSNV------------CGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDC 633
V +S ++ C G C + +G C C G+TG+YC E +++C
Sbjct: 1095 GAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCIN-AGNTHYCQCPLGYTGSYCEEQLDEC 1153
Query: 634 ESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDC 693
SNPC++G TC D + Y+C C G++G CE +++C PC NGGTC DLVN F C C
Sbjct: 1154 ASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSC 1213
Query: 694 KNGWKGKTCHSRDSQCDEAT-CNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP 752
G +G C C C NGG C D + C C G+ G C N CL NP
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDIN-ECLSNP 1272
Query: 753 CHNGGT--CVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW---YRCE 807
C + G+ C+ + CVC+ + G C + C PC N GTC N + C
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICR 1332
Query: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQE-VSGRPCITM 866
C PGF+G C+ + C C G CV +G RC CP S C+ + PC
Sbjct: 1333 CPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCP---SPRDCESGCASSPCQHG 1386
Query: 867 GSVIPDGAKWDDDCNTCQCLNG---RIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDD 923
GS P C +G + + P CL + G + D+
Sbjct: 1387 GSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDG-----VCDE 1441
Query: 924 QCFVHPCTGVGECRSSSLQPVKTKCTSD----SYYQDNCANITFT 964
C H C G S +++ C+S Y + C + T
Sbjct: 1442 ACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNT 1486
Score = 442 bits (1136), Expect = e-123
Identities = 249/756 (32%), Positives = 340/756 (44%), Gaps = 137/756 (18%)
Query: 303 HQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE---------------------------- 334
++PC+N G C C CPEG+ G C+
Sbjct: 32 YEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCR 91
Query: 335 ------------IAEHAC-LSDPCHNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCSP 380
H C +S PC N G+C S +EC C G+TG C D C
Sbjct: 92 CASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLS 150
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECE----------------------- 417
+ C++G TC + N F C C +TG+ C+ D NEC+
Sbjct: 151 HPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCP 210
Query: 418 ----------------AKPCVNAKSCKNL-IASYYCDCLPGWMGQNCDININDCLG-QCQ 459
PCVN +C+ ++ C+CLPG+ G C+ NI+DC +CQ
Sbjct: 211 QGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ 270
Query: 460 NDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP--CLNGGHCQNEINRFQCLCPTGF 517
N C D VN Y C CPP + G C D+DEC P C NGG C N + C+C G+
Sbjct: 271 NGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGW 330
Query: 518 SGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC----- 572
SG+ C +ID C C G+ C +R + + C CPE G C HL D C + PC
Sbjct: 331 SGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLC-HLDDACISNPCHKGAL 389
Query: 573 --------EVIDSCTVAMASNDTPEGV---RYISSNVCGPHGKCKSQSGGKFTCDCNKGF 621
+ I +C D E V +SN C GKC + + G F C+C KG+
Sbjct: 390 CDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVN-TDGAFHCECLKGY 448
Query: 622 TGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGT 681
G C +IN+C S+PC+N TC+D + + C+C G++G +CE IN+C NPC N G
Sbjct: 449 AGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQ 508
Query: 682 CRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCN 741
C D VN F C C G+ G C C C NG C D + ++C C G+ G C
Sbjct: 509 CVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCE 568
Query: 742 IARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGD 801
+C P+PCH+ G C +S+TC+C G+ G IC+ ++C PC N G C+D
Sbjct: 569 -ENIDNCDPDPCHH-GQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLV 626
Query: 802 NWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC----QE 857
N Y+C C PG +G +C IN ++C S+PC G C+D IN Y CVC PG +G +C E
Sbjct: 627 NGYQCNCQPGTSGVNCEINFDDCASNPCIHG-ICMDGINRYSCVCSPGFTGQRCNIDIDE 685
Query: 858 VSGRPCITMGSVIPDGAKWDDDCNTCQCLNG--RIAC-SKV-WCGPRPCLLHKGHSECPS 913
+ PC G+ +G + C C G +C S+V C PC+ H C
Sbjct: 686 CASNPC-RKGATCINGV----NGFRCICPEGPHHPSCYSQVNECLSNPCI----HGNCTG 736
Query: 914 GQSCIPILDD-------------QCFVHPCTGVGEC 936
G S L D +C +PC G C
Sbjct: 737 GLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTC 772
Score = 76.6 bits (187), Expect = 1e-13
Identities = 72/265 (27%), Positives = 97/265 (36%), Gaps = 73/265 (27%)
Query: 752 PCHNGGTCVV--NGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR--CE 807
PC N G CV NG + C C EG+ G C Q+ + C + C N GTCV + C
Sbjct: 34 PCVNEGMCVTYHNGTGY-CKCPEGFLGEYC-QHRDPCEKNRCQNGGTCVAQAMLGKATCR 91
Query: 808 CAPGFAGPDCRININE--CQSSPCAFGATC-VDEINGYRCVCPPGHSGAKCQEVSGRPCI 864
CA GF G DC+ + + S PC G TC + + Y C C G +G +CQ
Sbjct: 92 CASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-------- 143
Query: 865 TMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQ 924
W D C + C NG C+ V C G + GQ C +
Sbjct: 144 -----------WTDACLSHPCANGS-TCTTV-ANQFSCKCLTGFT----GQKC------E 180
Query: 925 CFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELR 984
V+ C G C+ C N+ ++ + P T C
Sbjct: 181 TDVNECDIPGHCQHGG----------------TCLNLPGSY--QCQCPQGFTGQYCD--- 219
Query: 985 NLNILKNVSAEYSIYIACEPSPSAN 1009
S+Y+ C PSP N
Sbjct: 220 ------------SLYVPCAPSPCVN 232
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 523 bits (1346), Expect = e-148
Identities = 285/852 (33%), Positives = 397/852 (46%), Gaps = 101/852 (11%)
Query: 220 CMEGWMGPECN-RAICRQGCSPKHGSCK---LPG----DCRCQYGWQGLYC---DKCIPH 268
C GW+G C C G G C+ + G CRC G++G C D C+
Sbjct: 67 CPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSS 126
Query: 269 PGCVHGI-CNEP----WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323
P C HG C+ + C C + G+ C D++ C +PC +GGTC NT P ++C
Sbjct: 127 P-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-PGSFRCQ 184
Query: 324 CPEGYSGPNCEIAEHACLSDPCHNRGSCKETS-LGFECECSPGWTGPTCSTNIDDCSPNN 382
CP GY+GP CE C PC N G+C+++ L ++C C PG+ G C N+DDC +
Sbjct: 185 CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHR 244
Query: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP--CVNAKSCKNLIASYYCDCLP 440
C +GGTC D VN + C CPP+WTG+ C D +EC+ +P C N +C N + + C C+
Sbjct: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVN 304
Query: 441 GWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNG 499
GW G++C NI+DC C + A+C D V + C CP G G C D D C SNPC
Sbjct: 305 GWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHED 363
Query: 500 GHCQ-NEIN-RFQCLCPTGFSGNLCQLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDY 555
C N +N R C CP GF+G C D+D C NPC++ +C N + C+C Y
Sbjct: 364 AICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
Query: 556 EGKNCSHLKDHCRTTPC-----------EVIDSCTVAMASNDTPEGVRYISSNVCGPHGK 604
G C + C + PC + C + S+ C G
Sbjct: 424 TGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGV 483
Query: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664
CK + G F+C C GF+G+ C ++++C S PCRNG C+D + Y+C C++G+EG C
Sbjct: 484 CKDRVNG-FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC 542
Query: 665 ETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEG 724
+ N++DCS +PCH+ G C D + F C C G+ G C S+ +C C +GG C D
Sbjct: 543 DRNVDDCSPDPCHH-GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLV 601
Query: 725 DAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN 784
D + C CP G G C + C NPC G C + CVC+ G+ GP+C N
Sbjct: 602 DKYLCRCPSGTTGVNCEV-NIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEIN 659
Query: 785 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844
+C+ PC G+CVDG+N +RC C PG P C + C PC+ G C D G+RC
Sbjct: 660 ECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRC 718
Query: 845 VCPPGHSGAKCQEVSGR------PCITMGSVIPDGAKWDDDC------------------ 880
VC PG SG +C + R PC G+ DG + C
Sbjct: 719 VCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPN 778
Query: 881 -----NTCQCLNGRI---ACSKVWCGPR------------PCLLH------KGHSECP-- 912
C+ G++ +C + W GPR PC H G C
Sbjct: 779 PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCH 838
Query: 913 ---SGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEM 969
+G SC ++D C +PC G C+ + C + CA
Sbjct: 839 GGYTGPSCDQDIND-CDPNPCLNGGSCQ-DGVGSFSCSCL-PGFAGPRCARDVDECLSNP 895
Query: 970 MSPGLTTEHICS 981
PG T+H+ S
Sbjct: 896 CGPGTCTDHVAS 907
Score = 501 bits (1290), Expect = e-141
Identities = 262/733 (35%), Positives = 362/733 (49%), Gaps = 65/733 (8%)
Query: 259 GLYCDKCIPHPGCVHG-----ICNEPWQCLCETNWGGQLCD-KDLNYCGTHQPCLNGGTC 312
G C+ C +G + + CLC W G+ C +D + G PC G C
Sbjct: 37 GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSG---PCAGRGVC 93
Query: 313 SNT---GPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG-FECECSPGWTG 368
++ G ++ C CP G+ GP+C + + CLS PC + C G F C C PG+ G
Sbjct: 94 QSSVVAGTARFSCRCPRGFRGPDCSLPD-PCLSSPCAHGARCSVGPDGRFLCSCPPGYQG 152
Query: 369 PTCSTNIDDCSPNN-CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC 427
+C +++D+C C HGGTC + F+C CP +TG C+ A C PC N +C
Sbjct: 153 RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC 212
Query: 428 KNL-IASYYCDCLPGWMGQNCDININDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCE 485
+ +Y C CLPG+ GQNC++N++DC G +C N +C D VN Y C CPP + G C
Sbjct: 213 RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Query: 486 RDIDECASNP--CLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNR 543
D+DEC P C NGG C N + C+C G++G C +ID C C +GA C++R
Sbjct: 273 EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR 332
Query: 544 ASDYFCKCPEDYEGKNCSHLKDHCRTTPC-------------EVIDSCTVAMASNDTPEG 590
+ ++C CP G C HL D C + PC I +C +
Sbjct: 333 VASFYCACPMGKTGLLC-HLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQD 391
Query: 591 VR--YISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
V I +N C G+C + + G F C C +G+TG C ++N+C S PCRN TC+D +
Sbjct: 392 VDECSIGANPCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450
Query: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
+ CIC G+ G YCE +I++C +PC NGG C+D VN F C C +G+ G TC +
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE 510
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARN-SSCLPNPCHNGGTCVVNGESFT 767
C C NG C D+ D ++C C G+EGT C+ RN C P+PCH+ G CV SF+
Sbjct: 511 CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCD--RNVDDCSPDPCHH-GRCVDGIASFS 567
Query: 768 CVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSS 827
C C G+ G C ++C PC + G C+D + Y C C G G +C +NI++C S+
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
Query: 828 PCAFGATCVDEINGYRCVCPPGHSGAKC----QEVSGRPCITMGSVIPDGAKWDDDCNTC 883
PC FG C D IN Y CVC PG +G C E + PC GS + DG ++ C
Sbjct: 628 PCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCV-DG----ENGFRC 681
Query: 884 QCLNGRI---------ACSKVWCGPRPCLLHKGHSECP-----SGQSCIPIL-DDQCFVH 928
C G + C+ C C G C SG C L D C
Sbjct: 682 LCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQ 741
Query: 929 PCTGVGECRSSSL 941
PC G C S +
Sbjct: 742 PCRAGGTCSSDGM 754
Score = 484 bits (1246), Expect = e-136
Identities = 264/756 (34%), Positives = 362/756 (47%), Gaps = 81/756 (10%)
Query: 220 CMEGWMGPECNR-------AICRQG--CSPKHGSCKLPGDCRCQYGWQGLYC---DKCIP 267
C+ GW G C++ A+C G C + S C C G GL C D C+
Sbjct: 302 CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFY----CACPMGKTGLLCHLDDACVS 357
Query: 268 HPGCVHGIC-----NEPWQCLCETNWGGQLCDKDLNYCGTH-QPCLNGGTCSNTGPDKYQ 321
+P IC N C C + G CD+D++ C PC + G C NT +
Sbjct: 358 NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT-QGSFL 416
Query: 322 CSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPN 381
C C GY+GP CE + CLS PC N+ +C + F C C G+TG C +ID+C +
Sbjct: 417 CQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSS 476
Query: 382 NCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPG 441
C +GG C+D VNGF C CP ++G TCQLD +EC + PC N C + Y C C G
Sbjct: 477 PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEG 536
Query: 442 WMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGH 501
+ G CD N++DC + C D + + C C PGY G CE +DEC S PC +GG
Sbjct: 537 FEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGK 596
Query: 502 CQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCS 561
C + ++++ C CP+G +G C+++ID C NPC G C + + Y C C + G C+
Sbjct: 597 CLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCN 655
Query: 562 HLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYI------------SSNVCG----PHGKC 605
+ C ++PC SC D G R + S+ C HG C
Sbjct: 656 VEINECASSPCGEGGSCV------DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
Query: 606 KSQSGGKFTCDCNKGFTGTYCHENI--NDCESNPCRNGGTCIDGVNSYKCICSDGWEGAY 663
GG F C C G++G C +++ + CES PCR GGTC + C C G +G
Sbjct: 710 YDAPGG-FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQ 768
Query: 664 CETNINDCSQNPCHNGGTCRDLVNDF-YCDCKNGWKGKTCHSRDSQC-DEATCNNGGTCY 721
CE ++ C+ NPC +GG C C C GW+G C +C A C G C
Sbjct: 769 CEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827
Query: 722 DEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
+ +F C C GG+ G +C+ N C PNPC NGG+C SF+C C G+ GP CA+
Sbjct: 828 NLAGSFSCTCHGGYTGPSCDQDIN-DCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
Query: 782 NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEING 841
+ ++C +PC GTC D + C C PG+ G C ++ +C S C G TCVD +N
Sbjct: 887 DVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNS 945
Query: 842 YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR- 900
+ C+C PG++GA CQ + D C + CL+G + CS G R
Sbjct: 946 FSCLCRPGYTGAHCQHEA------------------DPCLSRPCLHGGV-CSAAHPGFRC 986
Query: 901 PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGEC 936
CL E +G C L D C PC G C
Sbjct: 987 TCL------ESFTGPQC-QTLVDWCSRQPCQNGGRC 1015
Score = 462 bits (1188), Expect = e-129
Identities = 247/746 (33%), Positives = 344/746 (46%), Gaps = 84/746 (11%)
Query: 220 CMEGWMGPECNRAICRQGCSP--KHGSCKLPGD----CRCQYGWQGLYCDKCIP------ 267
C G+ GP CN I SP + GSC + G+ C C G C+P
Sbjct: 645 CQPGFTGPLCNVEINECASSPCGEGGSC-VDGENGFRCLCP---PGSLPPLCLPPSHPCA 700
Query: 268 HPGCVHGICNEP---WQCLCETNWGGQLCDKDL--NYCGTHQPCLNGGTCSNTGPDKYQC 322
H C HGIC + ++C+CE W G C + L + C + QPC GGTCS+ G + C
Sbjct: 701 HEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACES-QPCRAGGTCSSDGMG-FHC 758
Query: 323 SCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFE-CECSPGWTGPTCSTNIDDCS-P 380
+CP G G CE+ C +PC + G C+ C C GW GP C ++D+C+ P
Sbjct: 759 TCPPGVQGRQCELLS-PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGP 817
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLP 440
C G C +L F C C +TG +C D N+C+ PC+N SC++ + S+ C CLP
Sbjct: 818 APCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLP 877
Query: 441 GWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG 500
G+ G C ++++CL +C D V + C CPPGY G HCE+D+ +C+ + C NGG
Sbjct: 878 GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG 937
Query: 501 HCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
C + +N F CLC G++G CQ + D C PC +G C + C C E + G C
Sbjct: 938 TCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQC 997
Query: 561 SHLKDHCRTTPCEVIDSCTVAMASNDTPEG-------VRYIS------------SNVCGP 601
L D C PC+ C A P G +R + +C
Sbjct: 998 QTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
Query: 602 HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661
G+C + + C C +G TG++C + ++ C + PC++GGTC + Y C C G+ G
Sbjct: 1058 GGQCVDEDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNG 1116
Query: 662 AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEA-------TC 714
CE ++++C+ PC +GG+C DLV + C C G G C + C C
Sbjct: 1117 DNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRC 1176
Query: 715 NNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGT--CVVN-GESFTCVCK 771
+ GTC D F+C CP G+ G C A + C CH T C+ + G F C+C
Sbjct: 1177 LHNGTCVDLVGGFRCTCPPGYTGLRCE-ADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
Query: 772 EGWEGPICAQNTNDCSPHPCYNSGTC-----VDGDNWYRCECAPGFAGPDCRININECQS 826
G+ GP C + C PC + G C G + C CA F GP C C+
Sbjct: 1236 AGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRE 1295
Query: 827 SPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCL 886
C G C G RC CPPG SG C+ G P GA + C CL
Sbjct: 1296 LQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGS---------PPGAS-NASCAAAPCL 1345
Query: 887 NG------------RIACSKVWCGPR 900
+G R AC++ W GPR
Sbjct: 1346 HGGSCRPAPLAPFFRCACAQGWTGPR 1371
Score = 444 bits (1143), Expect = e-124
Identities = 271/876 (30%), Positives = 367/876 (41%), Gaps = 163/876 (18%)
Query: 219 TCMEGWMGPECNRAICRQGCSPKHGSCKLPG-----DCRCQYGWQGLYCDK----CIPHP 269
TC G+ G C + +P K +CRC G++G CD+ C P P
Sbjct: 494 TCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDP 553
Query: 270 GCVHGICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPE 326
C HG C + + C C + G C+ ++ C + QPC +GG C + DKY C CP
Sbjct: 554 -CHHGRCVDGIASFSCACAPGYTGTRCESQVDECRS-QPCRHGGKCLDL-VDKYLCRCPS 610
Query: 327 GYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHG 386
G +G NCE+ C S+PC G C++ ++C C PG+TGP C+ I++C+ + C G
Sbjct: 611 GTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEG 669
Query: 387 GTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQN 446
G+C D NGF+C+CPP C ++ C +PC + C + + C C PGW G
Sbjct: 670 GSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPR 728
Query: 447 CDINI--NDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQ 503
C ++ + C Q C+ +C G+ C CPPG G CE + C NPC +GG C+
Sbjct: 729 CSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCE 787
Query: 504 NEINRFQ-CLCPTGFSGNLCQLDIDYCE-PNPCQNGAQCYNRASDYFCKCPEDYEGKNCS 561
+ + C CP G+ G CQ D+D C P PC C N A + C C Y G +C
Sbjct: 788 SAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD 847
Query: 562 HLKDHCRTTPC-----------EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
+ C PC SC A V SN CGP G C
Sbjct: 848 QDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP-GTCTDHVA 906
Query: 611 GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE----- 665
FTC C G+ G +C +++ DC + C NGGTC+DGVNS+ C+C G+ GA+C+
Sbjct: 907 S-FTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
Query: 666 ---------------------------------TNINDCSQNPCHNGGTCRDLVNDFYCD 692
T ++ CS+ PC NGG C + YC
Sbjct: 966 CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCL 1023
Query: 693 CKNGWKGKTCHSRDSQCDEAT----------CNNGGTCYDEGDAFKCMCPGGWEGTTCNI 742
C GW G+ C R C EA C GG C DE + C+CP G G+ C
Sbjct: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE- 1082
Query: 743 ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
CL PC +GGTC + C C G+ G C + ++C+ PC + G+C+D
Sbjct: 1083 QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVA 1142
Query: 803 WYRCECAPGFAGPDCRININECQSSP-------CAFGATCVDEINGYRCVCPPGH----- 850
Y C C PG G C IN ++C P C TCVD + G+RC CPPG+
Sbjct: 1143 RYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRC 1202
Query: 851 ------------------------------------SGAKCQEV----SGRPCITMGSVI 870
SG +CQ V +PC G
Sbjct: 1203 EADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCR 1262
Query: 871 PDGAKWDDDCNTCQCLNG-------RIA--CSKVWC-----------GPRPCLLHKGHS- 909
P TC C R+A C ++ C GPR C G S
Sbjct: 1263 PSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR-CACPPGLSG 1321
Query: 910 -ECPSGQSCIPILDD-QCFVHPCTGVGECRSSSLQP 943
C S P + C PC G CR + L P
Sbjct: 1322 PSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAP 1357
Score = 383 bits (984), Expect = e-106
Identities = 245/768 (31%), Positives = 336/768 (43%), Gaps = 94/768 (12%)
Query: 219 TCMEGWMGPECNR-AICRQGCSPKHGSCK-LPGD---CRCQYGWQGLYC----DKCI-PH 268
TC G G +C + C G C+ PG C C GWQG C D+C P
Sbjct: 759 TCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPA 818
Query: 269 PGCVHGICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCP 325
P HGIC + C C + G CD+D+N C + PCLNGG+C + G + CSC
Sbjct: 819 PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN-PCLNGGSCQD-GVGSFSCSCL 876
Query: 326 EGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSH 385
G++GP C CLS+PC G+C + F C C PG+ G C ++ DCSP++C +
Sbjct: 877 PGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFN 935
Query: 386 GGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQ 445
GGTC D VN F C+C P +TG CQ +A+ C ++PC++ C + C CL + G
Sbjct: 936 GGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGP 995
Query: 446 NCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP--------- 495
C ++ C Q CQN C + G C+CPPG++G C+ C
Sbjct: 996 QCQTLVDWCSRQPCQNGGRC--VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQ 1053
Query: 496 -CLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPED 554
C GG C +E + C+CP G +G+ C+ ++D C PCQ+G C Y C+C
Sbjct: 1054 LCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPG 1113
Query: 555 YEGKNCSHLKDHCRTTPCEVIDSCT--VAMASNDTPEGVR----YISSNVCGP------- 601
Y G NC D C + PC+ SC VA P G I+ + CGP
Sbjct: 1114 YNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSG 1173
Query: 602 -----HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGT--CI-DGVNSYKC 653
+G C GG F C C G+TG C +IN+C S C T C+ D ++C
Sbjct: 1174 PRCLHNGTCVDLVGG-FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRC 1232
Query: 654 ICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVND-----FYCDCKNGWKGKTCHSRDSQ 708
+C G+ G C+T ++ C PC +GG CR F C C + G C
Sbjct: 1233 LCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARS 1292
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNI-------ARNSSCLPNPCHNGGTC-- 759
C E C G C +C CP G G +C A N+SC PC +GG+C
Sbjct: 1293 CRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
Query: 760 VVNGESFTCVCKEGWEGPIC--AQNTNDCSPHPCYNSGTCVDGDNWYRC--EC---APGF 812
F C C +GW GP C + S P C RC EC G+
Sbjct: 1353 APLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGW 1412
Query: 813 AGPDCRINI----NECQSSPC---AFGATCVDEINGYRCV-----CPPGHSGAKCQEVSG 860
G DC +++ +C++ C + C + C+ C G C V
Sbjct: 1413 DGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYE 1472
Query: 861 RPCITMGSVIPDGAKWDDDCNTCQC-LNGRIACSKVWCGPRPCLLHKG 907
+ C DG + D CNT +C +G S+V P LL +G
Sbjct: 1473 KYC---ADHFADG-RCDQGCNTEECGWDGLDCASEV-----PALLARG 1511
Score = 89.4 bits (220), Expect = 2e-17
Identities = 85/320 (26%), Positives = 115/320 (35%), Gaps = 78/320 (24%)
Query: 205 DFFGHYACDQNGNKTCMEGWMGPECNRAI--CRQG-CSPKHGSCKL--PGD---CRCQYG 256
D G + C TC G+ G C I CR G C H L PG C C G
Sbjct: 1184 DLVGGFRC------TCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
Query: 257 WQGLYCD---------------KCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCG 301
+ G C +C P PG G+ + C C + G C++ C
Sbjct: 1238 FSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLT---FTCHCAQPFWGPRCERVARSCR 1294
Query: 302 THQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE--------IAEHACLSDPCHNRGSCKE 353
Q C G C T P +C+CP G SGP+C + +C + PC + GSC+
Sbjct: 1295 ELQ-CPVGVPCQQT-PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
Query: 354 TSLG--FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL 411
L F C C+ GWTGP C + S C + C + + C
Sbjct: 1353 APLAPFFRCACAQGWTGPRCEA---PAAAPEVSEEPRCP------RAACQAKRGDQRCD- 1402
Query: 412 DANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGY 471
EC + C GW G +C +++ D QC+ C L N
Sbjct: 1403 --RECNSPGC-------------------GWDGGDCSLSVGDPWRQCE-ALQCWRLFNNS 1440
Query: 472 RCICPPGYAGDHCERDIDEC 491
R C P + C D +C
Sbjct: 1441 R--CDPACSSPACLYDNFDC 1458
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 494 bits (1271), Expect = e-139
Identities = 269/825 (32%), Positives = 375/825 (45%), Gaps = 111/825 (13%)
Query: 220 CMEGWMGPEC--NRAICRQGCSPKHGSCKLPGD---CRCQYGWQGLYC----DKCIPH-- 268
C G++GP+C N C G+C+ D C C W G C D+C
Sbjct: 264 CPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGP 323
Query: 269 PGCVHG-ICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSC 324
P C +G C + C+C + WGG C+++L+ C C G TC + + C C
Sbjct: 324 PHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC-IAATCAPGSTCIDR-VGSFSCLC 381
Query: 325 PEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFE--CECSPGWTGPTCSTNIDDC---- 378
P G +G C + E CLS PCH C L C C PG++GPTC ++D+C
Sbjct: 382 PPGRTGLLCHL-EDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQ 440
Query: 379 -SPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
P+ C HGG+C + F C+CPP +TG C+ D NEC ++PC +C +L+A+++C
Sbjct: 441 QGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCL 500
Query: 438 CLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPC 496
C PG GQ C++ N+C C N A C DL+NG++CIC PG++G CE DIDEC S+PC
Sbjct: 501 CPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPC 560
Query: 497 LNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYE 556
NGG CQ++ F C C GF G CQ ++D C +PC GA C + +FC CP +
Sbjct: 561 ANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFT 620
Query: 557 GK-----------------------------------------NCSHLKDHCRTTPCEVI 575
G+ NC+ HC+ + C
Sbjct: 621 GQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCV-- 678
Query: 576 DSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCES 635
C V + + S C G C Q G + C C G+TG C E + C S
Sbjct: 679 --CDVGWTGPECEAELGGCISAPCAHGGTCYPQPSG-YNCTCPTGYTGPTCSEEMTACHS 735
Query: 636 NPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKN 695
PC NGG+C Y C C G C+T+ + C PC NGGTC + F C C
Sbjct: 736 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAM 795
Query: 696 GWKGKTCHSR-DSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCH 754
G++G C + C ++ C N TC D +C+CP G+ G +C + C PC
Sbjct: 796 GFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDL-CAQKPCP 854
Query: 755 NGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHP----------CYNSGTCVDGDNWY 804
C+ G SF C+C +GW GP+C + C C+N G CVD Y
Sbjct: 855 RNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSY 914
Query: 805 RCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQE----VSG 860
C C PGF G C+ ++N C+S PC GATC+ + +GY C C PG+ G C +
Sbjct: 915 FCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQS 974
Query: 861 RPCITMGSVIPDGAKWDDDC-----------NTCQCLN------GRIACSKVWCGPRPCL 903
+PC G+ P + C + +CL+ G AC + C
Sbjct: 975 QPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSL-ANAFYCQ 1033
Query: 904 LHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKC 948
GH+ GQ C + D C PC G C +++ P+ C
Sbjct: 1034 CLPGHT----GQWC-EVEIDPCHSQPCFHGGTCEATAGSPLGFIC 1073
Score = 466 bits (1198), Expect = e-131
Identities = 253/786 (32%), Positives = 349/786 (44%), Gaps = 98/786 (12%)
Query: 219 TCMEGWMGPECNRAI---CRQGCSPKHGSCKLPGD----CRCQYGWQGLYC---DKCIPH 268
TC+ G+ G C + C K G C + C C GW G C D C +
Sbjct: 104 TCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSAN 163
Query: 269 PGCVHGICNEPW---QCLCETNWGGQLCDKDLNYCGTHQ-PCLNGGTCSNTGPDKYQCSC 324
P G+C + QC C + G C++D+N C PC G +C NT +QC C
Sbjct: 164 PCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNT-LGSFQCLC 222
Query: 325 PEGYSGPNCEIAEHACLSDPCHNRGSCK----ETSLGFECECSPGWTGPTCSTNIDDCSP 380
P G GP CE+ C C N G+C+ + S C C PG+ GP C N D+C
Sbjct: 223 PVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVS 282
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAK---PCVNAKSCKNLIASYYCD 437
+ C +GGTCQD ++ + C+CP WTG C D +ECE + C N +C+N S++C
Sbjct: 283 HQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCV 342
Query: 438 CLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPC 496
C+ GW G +C+ N++DC+ C ++C D V + C+CPPG G C + D C S PC
Sbjct: 343 CVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPC 401
Query: 497 LNGGHCQNE--INRFQCLCPTGFSGNLCQLDIDYC-----EPNPCQNGAQCYNRASDYFC 549
C CLC G+SG C D+D C P+PC++G C N + C
Sbjct: 402 HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461
Query: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASND--TPEGVR----YISSNVCGP-- 601
CP Y G C + C + PC +C +A+ P G+ + +N C
Sbjct: 462 LCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAP 521
Query: 602 ---HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDG 658
H C G F C C GF+GT C E+I++C S+PC NGG C D ++ C C G
Sbjct: 522 CLNHADCHDLLNG-FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPG 580
Query: 659 WEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGG 718
+EG C+T +++C +PC G +C DL F+C C +G+ G+ C C C
Sbjct: 581 FEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEV--PLCAPNLCQPKQ 638
Query: 719 TCYDEGDAFKCMCPG----------------------------GWEGTTCNIARNSSCLP 750
C D+ D C+CP GW G C A C+
Sbjct: 639 ICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECE-AELGGCIS 697
Query: 751 NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAP 810
PC +GGTC + C C G+ GP C++ C PC N G+C Y C C P
Sbjct: 698 APCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPP 757
Query: 811 GFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVI 870
GP C+ + + C S+PC G TCV+ + C+C G G +C+
Sbjct: 758 SHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE-------------- 803
Query: 871 PDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPC 930
K C C N R C GPR CL G+ +G SC ++ D C PC
Sbjct: 804 ---GKLRPSCADSPCRN-RATCQDSPQGPR-CLCPTGY----TGGSCQTLM-DLCAQKPC 853
Query: 931 TGVGEC 936
C
Sbjct: 854 PRNSHC 859
Score = 417 bits (1072), Expect = e-116
Identities = 235/688 (34%), Positives = 313/688 (45%), Gaps = 86/688 (12%)
Query: 300 CGTH-QPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK---ETS 355
CG+ +PC NGGTC + + C C G+ G C+ + + C N GSC+
Sbjct: 28 CGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAP 87
Query: 356 LG-----------FECECSPGWTGPTCSTNIDD-CSPNNCSHGGTCQDLVNGF-KCVCPP 402
LG F C C PG+TG C ++D C P+ CS G C +G +C C P
Sbjct: 88 LGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMP 147
Query: 403 QWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCL---GQCQ 459
WTG+ CQL + C A PCVN C C C PG+ G C+ ++N+C G C
Sbjct: 148 GWTGEQCQL-RDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 460 NDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQ----NEINRFQCLCPT 515
SC + + ++C+CP G G CE C C NGG CQ + CLCP
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 516 GFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVI 575
GF G C+++ D C + CQNG C + Y C CPE + G +CS D C T
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECET------ 320
Query: 576 DSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCES 635
+G + C G C++ S G F C C G+ GT C EN++DC +
Sbjct: 321 -------------QGPPH-----CRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCIA 361
Query: 636 NPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC--RDLVNDFYCDC 693
C G TCID V S+ C+C G G C + C PCH C L C C
Sbjct: 362 ATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCLC 420
Query: 694 KNGWKGKTCHSRDSQC-----DEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSC 748
+ G+ G TCH +C + C +GG+C + +F C+CP G+ G+ C A ++ C
Sbjct: 421 QPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE-ADHNEC 479
Query: 749 LPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCEC 808
L PCH G TC+ +F C+C G EG +C TN+C+ PC N C D N ++C C
Sbjct: 480 LSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCIC 539
Query: 809 APGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ----EVSGRPCI 864
PGF+G C +I+EC+SSPCA G C D+ + C C PG G +CQ E PC
Sbjct: 540 LPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPC- 598
Query: 865 TMGSVIPDGAKWDD--DCNTCQCLNGRIA--CSKVWCGPRPC--------LLHKGHSECP 912
P GA D C C +G C C P C K + CP
Sbjct: 599 ------PVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCP 652
Query: 913 SGQSCIPILDDQCFVHPCTGVGECRSSS 940
G +D C H G C+ SS
Sbjct: 653 DGSPGCAPPEDNCTCHH----GHCQRSS 676
Score = 414 bits (1064), Expect = e-115
Identities = 221/696 (31%), Positives = 307/696 (44%), Gaps = 91/696 (13%)
Query: 220 CMEGWMGPECNRAI-----CRQGCSP-KHG-SC-KLPG--DCRCQYGWQGLYCD----KC 265
C G+ GP C++ + +QG SP +HG SC PG +C C G+ G C+ +C
Sbjct: 420 CQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC 479
Query: 266 IP---HPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQC 322
+ HPG + CLC GQLC+ + N C + PCLN C + + +QC
Sbjct: 480 LSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECAS-APCLNHADCHDL-LNGFQC 537
Query: 323 SCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN 382
C G+SG CE C S PC N G C++ F C+C PG+ GP C T +D+C +
Sbjct: 538 ICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDP 597
Query: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDA---NECEAKP-CVNAKSCKNLIAS----- 433
C G +C DL F C+CP +TG+ C++ N C+ K C + K N +
Sbjct: 598 CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG 657
Query: 434 -----------------YYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCIC 475
C C GW G C+ + C+ C + +C +GY C C
Sbjct: 658 CAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTC 717
Query: 476 PPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQ 535
P GY G C ++ C S PCLNGG C + C CP +G CQ DYC PC
Sbjct: 718 PTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCF 777
Query: 536 NGAQCYNRASDYFCKCPEDYEGKNCS-HLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYI 594
NG C NR + C C ++G C L+ C +PC +C D+P+G R
Sbjct: 778 NGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC------QDSPQGPR-- 829
Query: 595 SSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCI 654
C C G+TG C ++ C PC C+ S+ C+
Sbjct: 830 --------------------CLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCL 869
Query: 655 CSDGWEGAYCETNINDCSQ----------NPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS 704
C GW G C ++ C + + CHNGG C D ++C C G++G C
Sbjct: 870 CLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQD 929
Query: 705 RDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE 764
+ C+ C NG TC + + C C G++G C+ +C PCHN GTC
Sbjct: 930 HVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCS-KELDACQSQPCHNHGTCTPKPG 988
Query: 765 SFTCVCKEGWEGPICAQNTNDCSPHPCYNSGT--CVDGDNWYRCECAPGFAGPDCRININ 822
F C C G+ G C + ++C PC+ +GT C N + C+C PG G C + I+
Sbjct: 989 GFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEID 1048
Query: 823 ECQSSPCAFGATCVDEIN---GYRCVCPPGHSGAKC 855
C S PC G TC G+ C CP G G C
Sbjct: 1049 PCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTC 1084
Score = 321 bits (823), Expect = 2e-87
Identities = 202/704 (28%), Positives = 280/704 (39%), Gaps = 116/704 (16%)
Query: 202 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY 261
P D+ H+ Q + C GW GPEC + G C C +G
Sbjct: 661 PEDNCTCHHGHCQRSSCVCDVGWTGPECEAEL---------GGCI---SAPCAHG----- 703
Query: 262 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ 321
C P P + C C T + G C +++ C + PCLNGG+C N P Y
Sbjct: 704 -GTCYPQP--------SGYNCTCPTGYTGPTCSEEMTACHS-GPCLNGGSC-NPSPGGYY 752
Query: 322 CSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI-DDCSP 380
C+CP ++GP C+ + C+S PC N G+C F C C+ G+ GP C + C+
Sbjct: 753 CTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCAD 812
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLP 440
+ C + TCQD G +C+CP +TG +CQ + C KPC C S++C CL
Sbjct: 813 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQ 872
Query: 441 GWMGQNCDININDC----LGQ-------CQNDASCRDLVNGYRCICPPGYAGDHCERDID 489
GW G C++ ++ C L Q C N C D Y C CPPG+ G C+ ++
Sbjct: 873 GWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVN 932
Query: 490 ECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC 549
C S PC NG C + + + C C G+ G C ++D C+ PC N C + + C
Sbjct: 933 PCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHC 992
Query: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609
CP + G C D C PC P G C S +
Sbjct: 993 ACPPGFVGLRCEGDVDECLDQPCH--------------PTGT-----------AACHSLA 1027
Query: 610 GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS---YKCICSDGWEGAYCET 666
F C C G TG +C I+ C S PC +GGTC S + C C G+EG C
Sbjct: 1028 NA-FYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSH 1086
Query: 667 NINDCSQNPCHNGGTCRDLVNDFY---CDCKNGWKGKTCHSRDSQ--C-DEATCNNGGTC 720
C + CH+GG C + C C +G+ G C + + C + C G+C
Sbjct: 1087 RAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSC 1146
Query: 721 YDE----GDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEG 776
+ G F+C CP G C C G S C G G
Sbjct: 1147 SETTGLGGPGFRCSCPHSSPGPRCQKPGAKGC-------------EGRSGDGACDAGCSG 1193
Query: 777 PICAQNTNDCS---PHP---CYNSGTC----VDGDNWYRCECAPGFAGPDCRININECQS 826
P + DCS P P C + C DG +C P +C + +C++
Sbjct: 1194 PGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDG------QCHPQCDSEECLFDGYDCET 1247
Query: 827 SPC---AFGATCVDEINGYRC-----VCPPGHSGAKCQEVSGRP 862
P A+ C D + C G G C+ G P
Sbjct: 1248 PPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDP 1291
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 490 bits (1261), Expect = e-138
Identities = 221/532 (41%), Positives = 300/532 (56%), Gaps = 15/532 (2%)
Query: 11 GRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDE 70
G +L LA+L AL +V +SG FEL++ N G L N NCC G P C
Sbjct: 2 GSRCALALAVLSALLCQVW-SSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPP--CA--- 55
Query: 71 CDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDR---NRIVLPFSFA 127
C T+F+VCLK YQ+ V+ PC++GS TPV+G ++F+L G D N I PF F
Sbjct: 56 CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFT 115
Query: 128 WPRSYTLLVEAW--DSSND--TVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQI 183
WP +++L++EA DS +D T P+ +I + + + +W ++G +Y
Sbjct: 116 WPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSY 175
Query: 184 RVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHG 243
R CD++YYG GC+ FCRPRDD FGH+ C + G K C GW GP C IC GC +HG
Sbjct: 176 RFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHG 235
Query: 244 SCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTH 303
C PG+C+C+ GWQG YCD+CI +PGC+HG C +PWQC C+ WGG C++DLNYC H
Sbjct: 236 FCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHH 295
Query: 304 QPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECS 363
+PC NG TC+NTG Y CSC GY+G CE+ C PC N GSC + + C C
Sbjct: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCP 355
Query: 364 PGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN-GFKCVCPPQWTGKTCQLDANECEAKPCV 422
PG+ G C + C+ C +GG C D + G+ C CP ++G C+ + C + PC
Sbjct: 356 PGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCS 415
Query: 423 NAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAG 481
N C +L +Y C C G+ G++CD N++DC C N +CRD VN + C CPPGY G
Sbjct: 416 NGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTG 475
Query: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNP 533
+C + C PC NG C +R+ C C G+ G CQ + P P
Sbjct: 476 RNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
Score = 241 bits (616), Expect = 2e-63
Identities = 135/426 (31%), Positives = 186/426 (43%), Gaps = 89/426 (20%)
Query: 320 YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCS 379
Y+ C E Y G C + D +C E E C+PGW GP C+ I C
Sbjct: 175 YRFVCDEHYYGEGCSVFCRP--RDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--CL 227
Query: 380 PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCL 439
P G C KP C C
Sbjct: 228 PGCDEQHGFCD----------------------------KPGE-------------CKCR 246
Query: 440 PGWMGQNCD--ININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN-P 495
GW G+ CD I CL G CQ ++C C G+ G C +D++ C + P
Sbjct: 247 VGWQGRYCDECIRYPGCLHGTCQQP---------WQCNCQEGWGGLFCNQDLNYCTHHKP 297
Query: 496 CLNGGHCQNE-INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPED 554
C NG C N + C C G++G C+L ID C+P+PC+NG C + + Y C CP
Sbjct: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
Query: 555 YEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFT 614
+ GK C AM D P C G+C G ++
Sbjct: 358 FYGKICE-----------------LSAMTCADGP----------CFNGGRCSDSPDGGYS 390
Query: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN 674
C C G++G C + I+ C S+PC NG C+D ++Y C C G+ G +C+ N++DC+ +
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450
Query: 675 PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGG 734
PC NGGTCRD VNDF C C G+ G+ C + S+C+ A C+NG TC++ G + C C G
Sbjct: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510
Query: 735 WEGTTC 740
+ G C
Sbjct: 511 YGGPNC 516
Score = 239 bits (611), Expect = 9e-63
Identities = 131/394 (33%), Positives = 182/394 (46%), Gaps = 49/394 (12%)
Query: 466 DLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD 525
DL YR +C Y G+ C C G E R + +C G+ G C
Sbjct: 170 DLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGE--RGEKVCNPGWKGPYCTEP 224
Query: 526 IDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASN 585
I C P + C CKC ++G+ C D C P C
Sbjct: 225 I--CLPGCDEQHGFCDKPGE---CKCRVGWQGRYC----DECIRYP-----GCL------ 264
Query: 586 DTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN-PCRNGGTC 644
HG C+ + C+C +G+ G +C++++N C + PC+NG TC
Sbjct: 265 ----------------HGTCQQP----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
Query: 645 ID-GVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCH 703
+ G SY C C G+ GA CE I++C +PC NGG+C DL N + C C G+ GK C
Sbjct: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
Query: 704 SRDSQCDEATCNNGGTCYDEGDA-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN 762
C + C NGG C D D + C CP G+ G C + C +PC NG CV
Sbjct: 365 LSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDL 423
Query: 763 GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININ 822
G+++ C C+ G+ G C N +DC+ PC N GTC DG N + C C PG+ G +C ++
Sbjct: 424 GDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS 483
Query: 823 ECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
C+ +PC GATC + + Y C C G+ G CQ
Sbjct: 484 RCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
Score = 220 bits (560), Expect = 7e-57
Identities = 118/370 (31%), Positives = 161/370 (43%), Gaps = 56/370 (15%)
Query: 474 ICPPGYAGDHCERDIDECASNPCLNG-----GHCQNEINRFQCLCPTGFSGNLCQLDIDY 528
+C PG+ G +C I CL G G C +C C G+ G C I Y
Sbjct: 211 VCNPGWKGPYCTEPI-------CLPGCDEQHGFCDKP---GECKCRVGWQGRYCDECIRY 260
Query: 529 --CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC-RTTPCEVIDSCTVAMASN 585
C CQ QC C E + G C+ ++C PC+ +CT
Sbjct: 261 PGCLHGTCQQPWQC---------NCQEGWGGLFCNQDLNYCTHHKPCKNGATCT------ 305
Query: 586 DTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCI 645
+ G +TC C G+TG C I++C+ +PC+NGG+C
Sbjct: 306 ---------------------NTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCT 344
Query: 646 DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHS 704
D NSY C C G+ G CE + C+ PC NGG C D + Y C C G+ G C
Sbjct: 345 DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK 404
Query: 705 RDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE 764
+ C + C+NG C D GDA+ C C G+ G C+ C +PC NGGTC
Sbjct: 405 KIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD-DNVDDCASSPCANGGTCRDGVN 463
Query: 765 SFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININEC 824
F+C C G+ G C+ + C PC+N TC + + Y CECA G+ GP+C+ + E
Sbjct: 464 DFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPEL 523
Query: 825 QSSPCAFGAT 834
P T
Sbjct: 524 PPGPAVVDLT 533
Score = 201 bits (512), Expect = 3e-51
Identities = 112/340 (32%), Positives = 153/340 (45%), Gaps = 53/340 (15%)
Query: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGV-------RYISSNVCGP-- 601
C E Y G+ CS C D + E V Y + +C P
Sbjct: 179 CDEHYYGEGCSVF--------CRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGC 230
Query: 602 ---HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDG 658
HG C C C G+ G YC E C P GTC ++C C +G
Sbjct: 231 DEQHGFCDKPG----ECKCRVGWQGRYCDE----CIRYPGCLHGTC---QQPWQCNCQEG 279
Query: 659 WEGAYCETNINDCSQN-PCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNN 716
W G +C ++N C+ + PC NG TC + Y C C+ G+ G TC +CD + C N
Sbjct: 280 WGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKN 339
Query: 717 GGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES-FTCVCKEGWE 775
GG+C D +++ C CP G+ G C ++ +C PC NGG C + + ++C C G+
Sbjct: 340 GGSCTDLENSYSCTCPPGFYGKICELSA-MTCADGPCFNGGRCSDSPDGGYSCRCPVGYS 398
Query: 776 GPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATC 835
G C + + CS PC N CVD + Y C C GF+G C N+++C SSPCA G TC
Sbjct: 399 GFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTC 458
Query: 836 VDEINGYRCVCPPG------------------HSGAKCQE 857
D +N + C CPPG H+GA C E
Sbjct: 459 RDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHE 498
Score = 179 bits (453), Expect = 2e-44
Identities = 109/323 (33%), Positives = 147/323 (45%), Gaps = 31/323 (9%)
Query: 599 CGPHGKCKSQSGGKFTCD------CNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYK 652
C + + + G FTC CN G+ G YC E I C G C +
Sbjct: 188 CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGE 242
Query: 653 CICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDE- 711
C C GW+G YC+ +C + P GTC+ + C+C+ GW G C+ + C
Sbjct: 243 CKCRVGWQGRYCD----ECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHH 295
Query: 712 ATCNNGGTCYDEGD-AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVC 770
C NG TC + G ++ C C G+ G TC + + C P+PC NGG+C S++C C
Sbjct: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDE-CDPSPCKNGGSCTDLENSYSCTC 354
Query: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDG-DNWYRCECAPGFAGPDCRININECQSSPC 829
G+ G IC + C+ PC+N G C D D Y C C G++G +C I+ C SSPC
Sbjct: 355 PPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
Query: 830 AFGATCVDEINGYRCVCPPGHSGAKC----QEVSGRPCITMGSVIPDGAKWDDDCNTCQC 885
+ GA CVD + Y C C G SG C + + PC G DG D C
Sbjct: 415 SNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN-GGTCRDGVN-DFSCTCPPG 472
Query: 886 LNGRIACSKV-WCGPRPCLLHKG 907
GR + V C PC H G
Sbjct: 473 YTGRNCSAPVSRCEHAPC--HNG 493
Score = 156 bits (394), Expect = 1e-37
Identities = 97/294 (32%), Positives = 124/294 (42%), Gaps = 55/294 (18%)
Query: 654 ICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS--RDSQCDE 711
+C+ GW+G YC I C G C D + C C+ GW+G+ C R C
Sbjct: 211 VCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYCDECIRYPGCLH 265
Query: 712 ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE-SFTCVC 770
TC ++C C GW G CN N PC NG TC G+ S+TC C
Sbjct: 266 GTCQQ---------PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC 316
Query: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCA 830
+ G+ G C ++C P PC N G+C D +N Y C C PGF G C ++ C PC
Sbjct: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
Query: 831 FGATCVDEING-YRCVCPPGHSGAKCQE----VSGRPCITMGSVIPDGAKWDD--DCNTC 883
G C D +G Y C CP G+SG C++ S PC +GAK D D C
Sbjct: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-------SNGAKCVDLGDAYLC 429
Query: 884 QCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECR 937
+C G SG+ C +DD C PC G CR
Sbjct: 430 RCQAGF-----------------------SGRHCDDNVDD-CASSPCANGGTCR 459
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 474 bits (1219), Expect = e-133
Identities = 213/522 (40%), Positives = 302/522 (57%), Gaps = 26/522 (4%)
Query: 18 LALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKV 77
L LL AL + SG F+L++ N G L +G C PG C T+F+V
Sbjct: 13 LLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPC----EPG--------CRTFFRV 60
Query: 78 CLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKA-SRGNDRNRIVLPFSFAWPRSYTLLV 136
CLK +Q+ V + GPC+FG+ STPV+G N+F ++ S G RN + LPF+F WP +++L++
Sbjct: 61 CLKHFQA-VVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLII 119
Query: 137 EAWDSSNDTVQP-----DSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYY 191
EAW + D ++P D++I K + G + + W +Q + + Y RV C D Y
Sbjct: 120 EAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNY 179
Query: 192 YGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDC 251
YG C++ C+ R+D FGHY C +GN +C+ GW G C + IC GC ++G C P +C
Sbjct: 180 YGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAEC 239
Query: 252 RCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGT 311
C+ GWQG C++CIPH GC HG C+ PWQC C+ WGG CD+DLNYC H PC NG T
Sbjct: 240 LCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGAT 299
Query: 312 CSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
CSN+G Y C+C GY+G +CE+ C S+PC N GSCK+ G+ C C PG+ G C
Sbjct: 300 CSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHC 359
Query: 372 STNIDDCSPNNCSHGGTCQDLVNG--FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKN 429
+ C+ + C +GG+C++ G + C CPP +TG C+ + C + PC N C N
Sbjct: 360 EHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLN 419
Query: 430 LIASYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCE--R 486
S C C PG+ G C+++++DC C + +C DL NG C CP G++G CE
Sbjct: 420 RGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT 479
Query: 487 DIDECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDI 526
ID CAS+PC N C ++ + F C CP GF G+ C+ +
Sbjct: 480 SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
Score = 233 bits (595), Expect = 6e-61
Identities = 128/388 (32%), Positives = 179/388 (46%), Gaps = 54/388 (13%)
Query: 362 CSPGWTGPTCSTNIDDCSPNNCSHGG-TCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP 420
CS + G CS C N G CQ N C P WTG+ CQ
Sbjct: 175 CSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGN---LSCLPGWTGEYCQQPI------- 221
Query: 421 CVNAKSCKNLIASYYCDCL--PGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPG 478
C++ +N S +CL PGW G+ C N+C+ N ++C C G
Sbjct: 222 CLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPH--NGCRHGTCSTPWQCTCDEG 275
Query: 479 YAGDHCERDIDECASN-PCLNGGHCQNEINR-FQCLCPTGFSGNLCQLDIDYCEPNPCQN 536
+ G C++D++ C + PC NG C N R + C C G++G C+L++ C+ NPC+N
Sbjct: 276 WGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRN 335
Query: 537 GAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISS 596
G C ++ Y C CP Y G +C H C +PC SC
Sbjct: 336 GGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCR----------------- 378
Query: 597 NVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICS 656
+ G + C+C FTG+ C + ++ C SNPC NGG C++ S C C
Sbjct: 379 ---------ERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCR 429
Query: 657 DGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS--QCDEATC 714
G+ G YCE +++DC++NPC +GGTC DL N C C G+ G+ C R S C + C
Sbjct: 430 PGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPC 489
Query: 715 NNGGTCYDE--GDAFKCMCPGGWEGTTC 740
N TCY + D F C CP G+ G+ C
Sbjct: 490 FNRATCYTDLSTDTFVCNCPYGFVGSRC 517
Score = 227 bits (579), Expect = 5e-59
Identities = 127/401 (31%), Positives = 187/401 (46%), Gaps = 56/401 (13%)
Query: 471 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE 530
YR IC Y GD+C R + N CQ + N C G++G CQ I C
Sbjct: 171 YRVICSDNYYGDNCSRLCKK--RNDHFGHYVCQPDGN---LSCLPGWTGEYCQQPI--CL 223
Query: 531 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG 590
+ C A C C ++G+ C
Sbjct: 224 SGCHEQNGYCSKPAE---CLCRPGWQGRLC------------------------------ 250
Query: 591 VRYISSNVCGPHGKCKSQS-GGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-G 647
N C PH C+ + + C C++G+ G +C +++N C +PC+NG TC + G
Sbjct: 251 ------NECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
Query: 648 VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS 707
SY C C G+ G CE +++C NPC NGG+C+D + ++C C G+ G C
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
Query: 708 QCDEATCNNGGTCYD--EGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES 765
C ++ C NGG+C + +G + C CP + G+ C + C NPC NGG C+ G S
Sbjct: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
Query: 766 FTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC--RININE 823
C C+ G+ G C + +DC+ +PC + GTC D +N C C GF+G C R +I+
Sbjct: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
Query: 824 CQSSPCAFGATCVDEING--YRCVCPPGHSGAKCQEVSGRP 862
C SSPC ATC +++ + C CP G G++C+ G P
Sbjct: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524
Score = 211 bits (538), Expect = 3e-54
Identities = 124/409 (30%), Positives = 181/409 (44%), Gaps = 63/409 (15%)
Query: 433 SYYCDCLPGWMGQNCDI---NINDCLGQ--CQNDASCRDLVNGYRCICPPGYAGDHCERD 487
SY C + G NC ND G CQ D + C PG+ G++C++
Sbjct: 170 SYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLS---------CLPGWTGEYCQQP 220
Query: 488 IDECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS 545
I CL+G H QN +CLC G+ G LC I + N C++G C ++
Sbjct: 221 I-------CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH---NGCRHGT-C---ST 266
Query: 546 DYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKC 605
+ C C E + G C ++C ++ +P C C
Sbjct: 267 PWQCTCDEGWGGLFCDQDLNYC----------------THHSP----------CKNGATC 300
Query: 606 KSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
+ +TC C G+TG C +++C+SNPCRNGG+C D + Y C+C G+ G +CE
Sbjct: 301 SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE 360
Query: 666 TNINDCSQNPCHNGGTCRDLVN--DFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE 723
+ C+ +PC NGG+CR+ ++ C+C + G C + +C C NGG C +
Sbjct: 361 HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR 420
Query: 724 GDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNT 783
G + C C G+ GT C + S C NPC +GGTC C C G+ G C T
Sbjct: 421 GPSRMCRCRPGFTGTYCEL-HVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT 479
Query: 784 N--DCSPHPCYNSGTCVD--GDNWYRCECAPGFAGPDCRININECQSSP 828
+ C+ PC+N TC + + C C GF G C + S P
Sbjct: 480 SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
Score = 207 bits (528), Expect = 4e-53
Identities = 116/357 (32%), Positives = 164/357 (45%), Gaps = 39/357 (10%)
Query: 551 CPEDYEGKNCSHL----KDHCRTTPCEVID--SCTVAMASNDTPEGVRYISSNVCGPHGK 604
C ++Y G NCS L DH C+ SC Y +C
Sbjct: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGE-------YCQQPIC--LSG 225
Query: 605 CKSQSG---GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661
C Q+G C C G+ G C+E I N CR+G TC ++C C +GW G
Sbjct: 226 CHEQNGYCSKPAECLCRPGWQGRLCNECI---PHNGCRHG-TCS---TPWQCTCDEGWGG 278
Query: 662 AYCETNINDCSQN-PCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNNGGT 719
+C+ ++N C+ + PC NG TC + Y C C+ G+ G C S+CD C NGG+
Sbjct: 279 LFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGS 338
Query: 720 CYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN--GESFTCVCKEGWEGP 777
C D+ D + C+CP G+ G C + SC +PC NGG+C G ++ C C + G
Sbjct: 339 CKDQEDGYHCLCPPGYYGLHCEHS-TLSCADSPCFNGGSCRERNQGANYACECPPNFTGS 397
Query: 778 ICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVD 837
C + + C+ +PC N G C++ C C PGF G C +++++C +PCA G TC D
Sbjct: 398 NCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHD 457
Query: 838 EINGYRCVCPPGHSGAKCQ------EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNG 888
NG C CP G SG +C+ + PC + D D C C G
Sbjct: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTD---LSTDTFVCNCPYG 511
Score = 147 bits (370), Expect = 8e-35
Identities = 94/296 (31%), Positives = 127/296 (42%), Gaps = 57/296 (19%)
Query: 650 SYKCICSDGWEGAYCETNINDCSQNPCHNGG-TCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
SY+ ICSD + G C C + H G C+ D C GW G+ C +
Sbjct: 170 SYRVICSDNYYGDNCS---RLCKKRNDHFGHYVCQP---DGNLSCLPGWTGEYC--QQPI 221
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNG---GTCVVNGES 765
C G C + C+C GW+G CN C+P HNG GTC
Sbjct: 222 CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCN-----ECIP---HNGCRHGTC---STP 267
Query: 766 FTCVCKEGWEGPICAQNTNDCSPH-PCYNSGTCVD-GDNWYRCECAPGFAGPDCRININE 823
+ C C EGW G C Q+ N C+ H PC N TC + G Y C C PG+ G DC + ++E
Sbjct: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
Query: 824 CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTC 883
C S+PC G +C D+ +GY C+CPPG+ G C+ + C
Sbjct: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST------------------LSCADS 369
Query: 884 QCLNGRIACSKVWCGPRPCLLHKGHSECP---SGQSCIPILDDQCFVHPCTGVGEC 936
C NG + C ECP +G +C + D+C +PC G+C
Sbjct: 370 PCFNGGSCRERNQGANYAC-------ECPPNFTGSNCEKKV-DRCTSNPCANGGQC 417
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 418 bits (1074), Expect = e-116
Identities = 262/892 (29%), Positives = 396/892 (44%), Gaps = 127/892 (14%)
Query: 214 QNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQG-LYCDKCIPHPG-- 270
++ N +C W E + IC GCS C W G +Y +
Sbjct: 518 EDNNSSC---WFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE 574
Query: 271 CVH-GIC----NEPWQCLCETNWGGQLCDKDLNYC-GTHQPCLNGGTCSNTGPDKYQCSC 324
C H +C N P +C C ++ G+LC +++YC G H ++G + + + C+C
Sbjct: 575 CQHEAVCKDEINRP-RCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALS----HNCNC 629
Query: 325 P--EGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN 382
+ Y CEI C S C N + F +C PG+ G C +ID+C+ +
Sbjct: 630 SGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHP 689
Query: 383 CSHGGTCQD--------------LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCK 428
C +G TC D +V+GF C+C P + G C+ D ++C C + +CK
Sbjct: 690 CKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCK 749
Query: 429 NLIASYYCDCLPGWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAGDHCERD 487
+L SY C CL W G C+ N+C + C+N+++C DL YRC C G+ G +C +
Sbjct: 750 DLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEE 809
Query: 488 IDECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDIDYCE--PNPCQNGAQCYNR 543
I+EC S+PC+NGG C +F CLCP ++G C + C+ NPC+N + C
Sbjct: 810 INECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLAL 869
Query: 544 A-SDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH 602
++ C C E++EGKNC C C+ +
Sbjct: 870 VDANQHCICREEFEGKNCEIDVKDCLFLSCQ---------------------------DY 902
Query: 603 GKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVN------------- 649
G C+ F C C GF+G+ C IN+C S PC+N GTC+D N
Sbjct: 903 GDCEDMVNN-FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGP 961
Query: 650 -------------------------SYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRD 684
Y C+C+ G+ G CE N+++C PC + G C D
Sbjct: 962 FCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCID 1021
Query: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR 744
+N + CDCK+G+ G C + + C C + G C + + + C C T C I
Sbjct: 1022 GINHYTCDCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIKI 1080
Query: 745 NSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHP-----CYNSGTCVD 799
N C PC N G C + FTC+C G+ G C ++ ++C+ C N G CVD
Sbjct: 1081 N-DCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVD 1139
Query: 800 G-DNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
G + + C C PGF+G C ININEC SSPC GA C D INGY C C PG SG C+
Sbjct: 1140 GPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE-- 1197
Query: 859 SGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACS-KVWCGPRPCLLHKGHSECPSGQSC 917
+ CI S + + ++ +TC C G + CS + CG + + P Q
Sbjct: 1198 NELECIP-NSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDE---IRRITCLTPIFQRT 1253
Query: 918 IPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMM-SPGLTT 976
PI Q + P + S++ + D+Y D T +++ + GL T
Sbjct: 1254 DPI-STQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLAT 1312
Query: 977 EHICSE-----LRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRD 1023
I + L+ L + + +SA++S+ + + S S + A+ ++D
Sbjct: 1313 LRISTPLESYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRDPAQIVQD 1364
Score = 328 bits (841), Expect = 2e-89
Identities = 243/936 (25%), Positives = 366/936 (39%), Gaps = 235/936 (25%)
Query: 229 CNRAICRQGCSPKHGSCKLPG-----DCRCQYGWQGLYC---DKCIPHPGCVHGIC---- 276
C ++ + CS HG C C CQ + G YC D C P +G C
Sbjct: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
Query: 277 ----NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPN 332
+ ++C+C + G+ C + + C H C +G CSN + + C C E +SGP
Sbjct: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV-CFHGN-CSNITSNSFICECDEQFSGPF 290
Query: 333 CEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392
CE++ C+S RG C +S + EC G + T++ + S C +G C +
Sbjct: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
Query: 393 VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININ 452
N C+C P +T C+ CE+ P N +CK Y C C+ G+ +NC+ I+
Sbjct: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
Query: 453 DC---LGQCQNDASCRDLVNGYRCICPPGYAGDHC--ERDIDECASNPCLNG----GHCQ 503
C C N+ C +++ ++ +C PG + C +++ + C G G CQ
Sbjct: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
Query: 504 NE-INRFQCLCPTGFSGN---LCQLDID-------YCEPNP------------------- 533
++ +F+ + GF+G+ CQ ID C +
Sbjct: 471 DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG 530
Query: 534 ----CQNGAQCYNR--------------ASDYFCKCPEDYEGKNCSH---LKDHCRTTPC 572
C NG C + A + + + D + C H KD C
Sbjct: 531 TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRC 590
Query: 573 EV------------IDSC-----------TVAMASNDTPEGVRYISSNVCGPHGK-CKSQ 608
+D C +A++ N G++ N+C + CKS
Sbjct: 591 SCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSA 650
Query: 609 S----------GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSY------- 651
S G F C GF GT C +I++C S+PC+NG TCID +Y
Sbjct: 651 SCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPP 710
Query: 652 ---------------------------------------------KCICSDGWEGAYCET 666
+C+C WEG +CE
Sbjct: 711 FKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQ 770
Query: 667 NINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE--G 724
N+C NPC N TC DL + C+C +GW G+ C ++CD C NGG C++
Sbjct: 771 ESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIP 830
Query: 725 DAFKCMCPGGWEGTTCNIARN-SSCLPNPCHNGGTCVVNGESFT-CVCKEGWE------- 775
F C+CP + G C+ N L NPC N TC+ ++ C+C+E +E
Sbjct: 831 GQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEID 890
Query: 776 -------------------------------GPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
G +C N+CS PC N+GTCVD N +
Sbjct: 891 VKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRF 950
Query: 805 RCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ----EVSG 860
C C P + GP C +++N+C+ SPC CV +GY C+C PG++G C+ E
Sbjct: 951 FCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLS 1010
Query: 861 RPCITMGSVIPDGAKWDDDC-------------NTC---QCLNGRIACSKVWCGPRPCLL 904
PC+ G I + DC N C CL+GR C+++ PC
Sbjct: 1011 EPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR--CTEL-INEYPC-- 1065
Query: 905 HKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940
++ S Q I I D C PC G C+ S+
Sbjct: 1066 -SCDADGTSTQCKIKIND--CTSIPCMNEGFCQKSA 1098
Score = 268 bits (686), Expect = 2e-71
Identities = 162/531 (30%), Positives = 233/531 (43%), Gaps = 107/531 (20%)
Query: 186 TCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQG--CSPKHG 243
TC D + + C C D+ G++ C+Q N EC C+ C+ +
Sbjct: 747 TCKDLHLSYQC--VCL--SDWEGNF-CEQESN----------ECKMNPCKNNSTCTDLYK 791
Query: 244 SCKLPGDCRCQYGWQGLYC----DKCIPHPGCVHGICNE---PWQ--CLCETNWGGQLCD 294
S + C C GW G C ++C P G+C+E P Q CLC + GQ C
Sbjct: 792 SYR----CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCH 847
Query: 295 KDLNYCGT-HQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKE 353
+ N C H PC N TC C C E + G NCEI CL C + G C++
Sbjct: 848 QRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCED 907
Query: 354 TSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDA 413
F C C PG++G C I++CS C + GTC DL N F C C P++ G C+LD
Sbjct: 908 MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDV 967
Query: 414 NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYR 472
N+C+ PC++ ++C Y C C PG+ G NC+IN+++CL + C +D C D +N Y
Sbjct: 968 NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYT 1027
Query: 473 CICPPGYAGDHCERDIDECASNPCLNG--------------------------------- 499
C C G+ G HCE + ++C SNPCL+G
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP 1087
Query: 500 ----GHCQNEINRFQCLCPTGFSGNLCQLDIDYC-EPN----PCQNGAQCYNRASDYF-C 549
G CQ + F C+CP G++G C+ ID C EP C NG C + F C
Sbjct: 1088 CMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDC 1147
Query: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHG-KCKSQ 608
+C + G+ C + C ++PC HG C+
Sbjct: 1148 RCLPGFSGQFCEININECSSSPC----------------------------LHGADCEDH 1179
Query: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGW 659
G + C C G++G +C EN +C N C + C++ C+C+ G+
Sbjct: 1180 ING-YVCKCQPGWSGHHC-ENELECIPNSCVH-ELCMENEPGSTCLCTPGF 1227
Score = 92.8 bits (229), Expect = 2e-18
Identities = 50/203 (24%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 663 YCETNINDCSQNPCHNGGTCRDLV--NDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTC 720
+C+ ++ S C G C + C C+ + GK C D+ C C N G+C
Sbjct: 173 FCQESL---SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSC 228
Query: 721 YDEGD-----AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE 775
++ + A++C+C + G C+ C P+ C +G + SF C C E +
Sbjct: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQ-CQPHVCFHGNCSNITSNSFICECDEQFS 287
Query: 776 GPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATC 835
GP C + C + G C + + Y EC G + + +++E PC G C
Sbjct: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC 347
Query: 836 VDEINGYRCVCPPGHSGAKCQEV 858
+ N C+C P + C+ +
Sbjct: 348 IKISNDVMCICSPIFTDLLCKSI 370
Score = 67.0 bits (162), Expect = 1e-10
Identities = 34/98 (34%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN 751
+ ++G + CH C C N GTC + + C CP + G C A SC N
Sbjct: 2324 EARHGKNIENCHV--PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA---SCENN 2378
Query: 752 PCHNGGTCV-VNGESFTCVCKEGWEGPICAQNTNDCSP 788
PC NG TCV +G C+C G GP+C N P
Sbjct: 2379 PCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 66.6 bits (161), Expect = 1e-10
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 12/96 (12%)
Query: 325 PEGYSGPNCEIAEHACLSDPCH-----NRGSCKETSLGFECECSPGWTGPTCSTNIDDCS 379
PEG+ PN + C + PC N G+C E+ C C+ GW G C+ + C
Sbjct: 2596 PEGH--PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCD 2653
Query: 380 -----PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQ 410
P++CS G TC L +G+ C CP TG C+
Sbjct: 2654 PEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 65.5 bits (158), Expect = 3e-10
Identities = 30/77 (38%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE-SFT 767
C TC NGG C G F C C W G TCN ++ SCL N C + C+ + S++
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN--QSVSCLNNLCLHQSLCIPDQSFSYS 2936
Query: 768 CVCKEGWEGPICAQNTN 784
C+C GW G C T+
Sbjct: 2937 CLCTLGWVGRYCENKTS 2953
Score = 64.7 bits (156), Expect = 5e-10
Identities = 31/88 (35%), Positives = 39/88 (44%), Gaps = 5/88 (5%)
Query: 665 ETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEA-----TCNNGGT 719
+ + + CS C NGGTC + YC+C GWKG C S CD C+ G T
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 720 CYDEGDAFKCMCPGGWEGTTCNIARNSS 747
C + C CP G G C A + S
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQALSIS 2695
Score = 63.2 bits (152), Expect = 1e-09
Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 618 NKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCS----- 672
N G + CH + C C NGGTCI+ S C C+ GW+G++C ++ C
Sbjct: 2601 NAGRSVGQCHAS--PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDP 2658
Query: 673 QNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNN 716
+ C G TC L + + C C G G C S D + +N
Sbjct: 2659 PHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSN 2702
Score = 63.2 bits (152), Expect = 1e-09
Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 5/77 (6%)
Query: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCS-----PHPCYNSGTCVDG 800
S C C NGGTC+ +G S C C GW+G C + + C PH C TC+
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL 2671
Query: 801 DNWYRCECAPGFAGPDC 817
+ Y C C G G C
Sbjct: 2672 PHGYTCFCPLGTTGIYC 2688
Score = 62.4 bits (150), Expect = 3e-09
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 702 CHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSC-----LPNPCHNG 756
CH+ S C C NGGTC + G + C C GW+G+ C S+C P+ C G
Sbjct: 2609 CHA--SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-ETVSTCDPEHDPPHHCSRG 2665
Query: 757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSP 788
TC+ +TC C G G C Q + P
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQALSISDP 2697
Score = 61.6 bits (148), Expect = 4e-09
Identities = 83/308 (26%), Positives = 113/308 (36%), Gaps = 59/308 (19%)
Query: 306 CLNGGTCS----NTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETS-LGFEC 360
C NGGTC ++G +QC CP ++G CE + A L P N S E L F
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE--KDAGLFFPSFNGNSYLELPFLKFVL 2165
Query: 361 ECSPGWTGP---TCSTN-----IDDCSPNNCSHG-----------------GTCQDLV-- 393
E T T TN I + NNC G Q+++
Sbjct: 2166 EKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTV 2225
Query: 394 --------NGF-----KCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIAS--YYCDC 438
N F + P G C ++ + KP V K + AS Y+
Sbjct: 2226 SANYSINTNAFTPITIRYTTPVGSPGVVCMIEMT-ADGKPPVQKKDTEISHASQAYFESM 2284
Query: 439 LPGWMGQNCDININDCLGQCQNDASC---RDLVNGYRCICPPGYAGDHCER-DIDECASN 494
G + N + I+ G C + N I G + E + CA +
Sbjct: 2285 FLGHIPAN--VQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHH 2342
Query: 495 PCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRA-SDYFCKCPE 553
C N G C ++ C CP +SG LCQ CE NPC NGA C ++ +D C CP
Sbjct: 2343 LCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVCLCPY 2400
Query: 554 DYEGKNCS 561
G C+
Sbjct: 2401 GRSGPLCT 2408
Score = 60.8 bits (146), Expect = 7e-09
Identities = 28/83 (33%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 410 QLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ------CQNDAS 463
Q A+ C C N +C S YC+C GW G C ++ C + C A+
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 464 CRDLVNGYRCICPPGYAGDHCER 486
C L +GY C CP G G +CE+
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQ 2690
Score = 60.1 bits (144), Expect = 1e-08
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 782 NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP-----CAFGATCV 836
+ + CS C N GTC++ C C G+ G C ++ C C+ GATC+
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669
Query: 837 DEINGYRCVCPPGHSGAKCQE 857
+GY C CP G +G C++
Sbjct: 2670 SLPHGYTCFCPLGTTGIYCEQ 2690
Score = 58.9 bits (141), Expect = 3e-08
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 733 GGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCY 792
G G+ ++C N C NGG C VNG +F+C C W G C Q+ + C + C
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCL 2922
Query: 793 NSGTCVDGDNW-YRCECAPGFAGPDC 817
+ C+ ++ Y C C G+ G C
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 57.8 bits (138), Expect = 6e-08
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 339 ACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTC-QDLVNGFK 397
AC + C N G C F C C P W G TC+ ++ C N C H C D +
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYS 2936
Query: 398 CVCPPQWTGKTCQLDANECEAK 419
C+C W G+ C+ + AK
Sbjct: 2937 CLCTLGWVGRYCENKTSFSTAK 2958
Score = 57.0 bits (136), Expect = 1e-07
Identities = 73/325 (22%), Positives = 119/325 (36%), Gaps = 48/325 (14%)
Query: 378 CSPNNCSHGGTCQDL-----VNGFKCVCPPQWTGKTCQLDAN------------ECEAKP 420
C + C +GGTC + + F+C CP +TG+ C+ DA E
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLK 2162
Query: 421 CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYA 480
V K + Y G N N+C Q + LV G P
Sbjct: 2163 FVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLH----LFLVEGR----PSVKY 2214
Query: 481 GDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC 540
G ++I ++N +N R+ P G G +C +++ P Q
Sbjct: 2215 GCGNSQNILTVSANYSINTNAFTPITIRY--TTPVGSPGVVCMIEMTADGKPPVQKKDTE 2272
Query: 541 YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASN--------DTPEG-- 590
+ AS + + + G ++++ H + P C + + N + G
Sbjct: 2273 ISHASQAYFE--SMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKN 2330
Query: 591 -----VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCI 645
V + + ++C +G C S + F C+C + ++G C CE+NPC NG TC+
Sbjct: 2331 IENCHVPWCAHHLCRNNGTCISDNENLF-CECPRLYSGKLC--QFASCENNPCGNGATCV 2387
Query: 646 -DGVNSYKCICSDGWEGAYCETNIN 669
C+C G G C IN
Sbjct: 2388 PKSGTDIVCLCPYGRSGPLCTDAIN 2412
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/72 (38%), Positives = 37/72 (51%), Gaps = 6/72 (8%)
Query: 599 CGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDC--ESNP---CRNGGTCIDGVNSYKC 653
CG G C +SG C+C G+ G++C E ++ C E +P C G TCI + Y C
Sbjct: 2619 CGNGGTC-IESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 654 ICSDGWEGAYCE 665
C G G YCE
Sbjct: 2678 FCPLGTTGIYCE 2689
Score = 56.2 bits (134), Expect = 2e-07
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE-GDAFKC 729
C+ + C N GTC + +C+C + GK C + + C+ C NG TC + G C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVC 2396
Query: 730 MCPGGWEGTTCNIARN 745
+CP G G C A N
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 55.1 bits (131), Expect = 4e-07
Identities = 27/85 (31%), Positives = 39/85 (45%), Gaps = 7/85 (8%)
Query: 629 NINDCES-----NPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC- 682
N+ DC+ N CRNGG C ++ C C W G C +++ C N C + C
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCI 2928
Query: 683 RDLVNDFYCDCKNGWKGKTCHSRDS 707
D + C C GW G+ C ++ S
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYCENKTS 2953
Score = 53.9 bits (128), Expect = 9e-07
Identities = 33/114 (28%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 270 GCVHG--ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEG 327
GC+ + N+ + + E G + + + +C H C N GTC + + + C CP
Sbjct: 2307 GCILDLQVNNKEFFIIDEARHGKNIENCHVPWCA-HHLCRNNGTCISDNENLF-CECPRL 2364
Query: 328 YSGPNCEIAEHACLSDPCHNRGSC-KETSLGFECECSPGWTGPTCSTNIDDCSP 380
YSG C+ A +C ++PC N +C ++ C C G +GP C+ I+ P
Sbjct: 2365 YSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 53.9 bits (128), Expect = 9e-07
Identities = 26/70 (37%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Query: 597 NVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCI-DGVNSYKCIC 655
N C G+C + +G F+C C + G C+++++ C +N C + CI D SY C+C
Sbjct: 2882 NTCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSCLC 2939
Query: 656 SDGWEGAYCE 665
+ GW G YCE
Sbjct: 2940 TLGWVGRYCE 2949
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/86 (33%), Positives = 37/86 (43%), Gaps = 7/86 (8%)
Query: 661 GAYCETNINDCS-----QNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCN 715
GA +N+ DC N C NGG C F C C W G TC+ S C C
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCL 2922
Query: 716 NGGTCY-DEGDAFKCMCPGGWEGTTC 740
+ C D+ ++ C+C GW G C
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 52.4 bits (124), Expect = 3e-06
Identities = 32/91 (35%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 748 CLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW-YRC 806
C + C N GTC+ + E+ C C + G +C C +PC N TCV C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVC 2396
Query: 807 ECAPGFAGPDCRININECQ---SSPCAFGAT 834
C G +GP C IN Q S AFG T
Sbjct: 2397 LCPYGRSGPLCTDAINITQPRFSGTDAFGYT 2427
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/85 (30%), Positives = 36/85 (42%), Gaps = 10/85 (11%)
Query: 486 RDIDECASNPCL-----NGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE-----PNPCQ 535
R + +C ++PC NGG C C C TG+ G+ C + C+ P+ C
Sbjct: 2604 RSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCS 2663
Query: 536 NGAQCYNRASDYFCKCPEDYEGKNC 560
GA C + Y C CP G C
Sbjct: 2664 RGATCISLPHGYTCFCPLGTTGIYC 2688
Score = 50.8 bits (120), Expect = 8e-06
Identities = 28/78 (35%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 626 CHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC-RD 684
CH + C + CRN GTCI + C C + G C+ C NPC NG TC
Sbjct: 2334 CH--VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPK 2389
Query: 685 LVNDFYCDCKNGWKGKTC 702
D C C G G C
Sbjct: 2390 SGTDIVCLCPYGRSGPLC 2407
Score = 49.7 bits (117), Expect = 2e-05
Identities = 27/75 (36%), Positives = 36/75 (48%), Gaps = 3/75 (4%)
Query: 458 CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR-FQCLCPTG 516
C+N+ +C C CP Y+G C+ C +NPC NG C + CLCP G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVCLCPYG 2401
Query: 517 FSGNLCQLDIDYCEP 531
SG LC I+ +P
Sbjct: 2402 RSGPLCTDAINITQP 2416
Score = 48.9 bits (115), Expect = 3e-05
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 1/75 (1%)
Query: 412 DANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASC-RDLVNG 470
D C C N C ++ C CLP W G C+ +++ C + + C D
Sbjct: 2875 DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFS 2934
Query: 471 YRCICPPGYAGDHCE 485
Y C+C G+ G +CE
Sbjct: 2935 YSCLCTLGWVGRYCE 2949
Score = 47.4 bits (111), Expect = 8e-05
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 12/83 (14%)
Query: 450 NINDCLGQ------CQNDASCRDLVNG--YRCICPPGYAGDHCERDIDECASNPCLNGGH 501
N+ DC G C+N C VNG + C C P +AG+ C + + C +N CL+
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECT--VNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSL 2926
Query: 502 C-QNEINRFQCLCPTGFSGNLCQ 523
C ++ + CLC G+ G C+
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 47.4 bits (111), Expect = 8e-05
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 775 EGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGAT 834
+G C NT C N G C + C C P +AG C +++ C ++ C +
Sbjct: 2875 DGTACGYNT-------CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSL 2926
Query: 835 CV-DEINGYRCVCPPGHSGAKCQ 856
C+ D+ Y C+C G G C+
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/132 (25%), Positives = 48/132 (36%), Gaps = 32/132 (24%)
Query: 520 NLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCT 579
N+ + +C + C+N C + + FC+CP Y GK C+ CE
Sbjct: 2330 NIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGK-------LCQFASCE------ 2376
Query: 580 VAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCR 639
+N CG C +SG C C G +G C + IN + R
Sbjct: 2377 ----------------NNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP---R 2417
Query: 640 NGGTCIDGVNSY 651
GT G S+
Sbjct: 2418 FSGTDAFGYTSF 2429
Score = 45.4 bits (106), Expect = 3e-04
Identities = 26/67 (38%), Positives = 32/67 (47%), Gaps = 7/67 (10%)
Query: 282 CLCETNWGGQLCDKDLNYCG-THQP---CLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAE 337
C C T W G C + ++ C H P C G TC + P Y C CP G +G CE A
Sbjct: 2634 CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL-PHGYTCFCPLGTTGIYCEQA- 2691
Query: 338 HACLSDP 344
+SDP
Sbjct: 2692 -LSISDP 2697
Score = 45.4 bits (106), Expect = 3e-04
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 2/73 (2%)
Query: 491 CASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCY-NRASDYFC 549
C N C NGG C F C C ++GN C + C N C + + C +++ Y C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 550 KCPEDYEGKNCSH 562
C + G+ C +
Sbjct: 2938 LCTLGWVGRYCEN 2950
Score = 44.3 bits (103), Expect = 7e-04
Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 10/83 (12%)
Query: 306 CLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDP-------CHNRGSCKETSLGF 358
C NGGTC +G Y C+C G+ G C C DP C +C G+
Sbjct: 2619 CGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTC--DPEHDPPHHCSRGATCISLPHGY 2675
Query: 359 ECECSPGWTGPTCSTNIDDCSPN 381
C C G TG C + P+
Sbjct: 2676 TCFCPLGTTGIYCEQALSISDPS 2698
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/74 (35%), Positives = 30/74 (40%), Gaps = 12/74 (16%)
Query: 269 PGCVHGIC---------NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDK 319
P C H +C NE C C + G+LC C + PC NG TC
Sbjct: 2337 PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASC-ENNPCGNGATCVPKSGTD 2393
Query: 320 YQCSCPEGYSGPNC 333
C CP G SGP C
Sbjct: 2394 IVCLCPYGRSGPLC 2407
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 7/83 (8%)
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAK-----PCVNAKSCKNLIA 432
CS C +GGTC + C C W G C + C+ + C +C +L
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 433 SYYCDCLPGWMGQNCD--ININD 453
Y C C G G C+ ++I+D
Sbjct: 2674 GYTCFCPLGTTGIYCEQALSISD 2696
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/103 (23%), Positives = 39/103 (37%), Gaps = 23/103 (22%)
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C C NG C + +C C ++G C+ E + +C +D P
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-----------ETVSTCD---PEHDPP 2659
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIN 631
++ + PHG +TC C G TG YC + ++
Sbjct: 2660 HHCSRGATCISLPHG---------YTCFCPLGTTGIYCEQALS 2693
Score = 40.0 bits (92), Expect = 0.014
Identities = 24/107 (22%), Positives = 37/107 (34%), Gaps = 28/107 (26%)
Query: 520 NLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCT 579
N+ D C N C+NG +C + + C+C D+ G C+ SC
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV------------SCL 2917
Query: 580 VAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
+N+C C ++C C G+ G YC
Sbjct: 2918 ----------------NNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 39.7 bits (91), Expect = 0.018
Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 21/87 (24%)
Query: 226 GPECNRAICRQGCSPKHGSCKLPG---DCRCQYGWQGLYCDKCIPHPGCVHGIC------ 276
G C CR G G C + G CRC W G C++ + C++ +C
Sbjct: 2876 GTACGYNTCRNG-----GECTVNGTTFSCRCLPDWAGNTCNQSV---SCLNNLCLHQSLC 2927
Query: 277 ----NEPWQCLCETNWGGQLCDKDLNY 299
+ + CLC W G+ C+ ++
Sbjct: 2928 IPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 37.0 bits (84), Expect = 0.11
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 5/37 (13%)
Query: 671 CSQNPCHNGGTCRDL-----VNDFYCDCKNGWKGKTC 702
C Q+ CHNGGTC + + F CDC + G+ C
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139
Score = 34.7 bits (78), Expect = 0.57
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 735 WEGTTCNIARNSSCLPNPCHNGGTC----VVNG-ESFTCVCKEGWEGPICAQN 782
W + ++A S C + CHNGGTC + +G SF C C + G C ++
Sbjct: 2090 WTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
Score = 34.3 bits (77), Expect = 0.74
Identities = 18/60 (30%), Positives = 24/60 (40%), Gaps = 8/60 (13%)
Query: 212 CDQNGNK---TCMEGWMGPECNRAICRQGCSPKHGSCKLPGD-----CRCQYGWQGLYCD 263
C NG C+ W G CN+++ H S +P C C GW G YC+
Sbjct: 2890 CTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 33.5 bits (75), Expect = 1.3
Identities = 15/55 (27%), Positives = 24/55 (43%), Gaps = 2/55 (3%)
Query: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334
+ C C +W G C++ ++ + CL+ C Y C C G+ G CE
Sbjct: 2897 FSCRCLPDWAGNTCNQSVSCL--NNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 32.3 bits (72), Expect = 2.8
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 5/41 (12%)
Query: 336 AEHACLSDPCHNRGSCKETSL-----GFECECSPGWTGPTC 371
A C D CHN G+C L F+C+C +TG C
Sbjct: 2099 APSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139
Score = 30.8 bits (68), Expect = 8.2
Identities = 21/68 (30%), Positives = 26/68 (38%), Gaps = 6/68 (8%)
Query: 824 CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS--GRPCITMGSVIPDGAKWDDDCN 881
C C TC+ + C CP +SG CQ S PC + +P K D
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVP---KSGTDI- 2394
Query: 882 TCQCLNGR 889
C C GR
Sbjct: 2395 VCLCPYGR 2402
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 390 bits (1001), Expect = e-108
Identities = 223/648 (34%), Positives = 288/648 (44%), Gaps = 67/648 (10%)
Query: 293 CDKDLNYCGTHQPCLNGGTCSN---TGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRG 349
C + C +PCLNGG C + TG Y CSC G++G C + + C S PC N G
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 350 SCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC 409
+C F C+C G+ GPTC T C C HGG CQ CVC +TG C
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAAC 384
Query: 410 QLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD----CL-GQCQNDASC 464
++D ++C PC+N SC +L+ +Y C C + G C+ + CL C N +C
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444
Query: 465 RDLVNGYRCICPPGYAGDHC-ERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ 523
D GY C CP G+ G C ER D+C C NGG C N C CP GF G LC+
Sbjct: 445 VDADQGYVCECPEGFMGLDCRERVPDDC---ECRNGGRCLG-ANTTLCQCPLGFFGLLCE 500
Query: 524 LDIDY--CEPN-PCQNGAQCYNRASDYFCKCPEDYEGKNCSH-LKDHCRTTPCEVIDSCT 579
+I C N C +G C Y C C D+ N SH L C + PC SC
Sbjct: 501 FEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDH---NASHSLPSPCDSDPCFNGGSCD 557
Query: 580 VAMASN--DTPEGV----------RYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
S + P G SS C G CK ++GG++ C C FTG +C
Sbjct: 558 AHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCK-EAGGEYHCSCPYRFTGRHCE 616
Query: 628 ENIND-CESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 686
D C S PC NGGTC + YKC C G+ G +CE + C ++PC NGGTC D
Sbjct: 617 IGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRD 676
Query: 687 NDFYCDCKNGWKGKTCHSR-----DSQCDEATCNNGGT--------CYDEGDAFK----- 728
DF+C C+ G+ G+ C + + AT GT D G +
Sbjct: 677 TDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRI 736
Query: 729 --CMCPGGW-EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND 785
C G W E C C PC +GG+C + C+C G+EG C ++
Sbjct: 737 RVCQPHGVWSEPPQC--LEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDE 794
Query: 786 CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCV 845
C HPC N G+C + Y C C GF G C ++ C SSPC G C Y CV
Sbjct: 795 CRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCV 854
Query: 846 CPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACS 893
CP G C+ VS PC + P G + C NG +C+
Sbjct: 855 CPESFFGYHCETVSD-PCFSS----PCGGR-----GYCLASNGSHSCT 892
Score = 348 bits (894), Expect = 1e-95
Identities = 197/658 (29%), Positives = 282/658 (42%), Gaps = 104/658 (15%)
Query: 264 KCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323
KCI CV G N + C C + + G+ C D+N C + QPC NGGTC++ G + ++C
Sbjct: 283 KCIDD--CVTG--NPSYTCSCLSGFTGRRCHLDVNECAS-QPCQNGGTCTH-GINSFRCQ 336
Query: 324 CPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNC 383
CP G+ GP CE A+ C + C + G C+ + C C G+TG C ++DDCSP+ C
Sbjct: 337 CPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPC 396
Query: 384 SHGGTCQDLVNGFKCVCPPQWTGKTCQLD----ANECEAKPCVNAKSCKNLIASYYCDCL 439
+GG+C DLV + C+C + G C+ + C + PC N +C + Y C+C
Sbjct: 397 LNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECP 456
Query: 440 PGWMGQNCDINI-NDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDI---------- 488
G+MG +C + +DC +C+N C N C CP G+ G CE +I
Sbjct: 457 EGFMGLDCRERVPDDC--ECRNGGRCLG-ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQ 513
Query: 489 -----------------------------DECASNPCLNGGHCQNEINRFQCLCPTGFSG 519
C S+PC NGG C + + C CP GF G
Sbjct: 514 CPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHG 573
Query: 520 NLCQLDIDY-CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLK-DHCRTTPCEVIDS 577
C+ + C PC+NG C +Y C CP + G++C K D C + PC +
Sbjct: 574 KHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGT 633
Query: 578 CTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNP 637
C YI GK+ CDC GF+G +C + C +P
Sbjct: 634 C------------FHYI----------------GKYKCDCPPGFSGRHCEIAPSPCFRSP 665
Query: 638 CRNGGTCIDGVNSYKCICSDGWEGAYCETNIN-----DCSQNPCHNGGTCRDLVNDFYCD 692
C NGGTC D + C C G+ G C+ ++ + GT V + CD
Sbjct: 666 CVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACD 725
Query: 693 -------------CK--NGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEG 737
C+ W +C C +GG+C D + C+C G+EG
Sbjct: 726 RGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEG 785
Query: 738 TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTC 797
C + R+ C +PC NGG+C ++ C C G+ G C + C PC + G C
Sbjct: 786 AHCELERDE-CRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC 844
Query: 798 VDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC 855
G Y C C F G C + C SSPC C+ + C C G++G C
Sbjct: 845 ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902
Score = 346 bits (888), Expect = 7e-95
Identities = 202/635 (31%), Positives = 288/635 (45%), Gaps = 100/635 (15%)
Query: 219 TCMEGWMGPECNRAI-------CRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKC---IPH 268
+C+ G+ G C+ + C+ G + HG C+C G+ G C+
Sbjct: 298 SCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFR--CQCPAGFGGPTCETAQSPCDT 355
Query: 269 PGCVHG----ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSC 324
C HG + N C+C+ + G C+ D++ C PCLNGG+C + Y C C
Sbjct: 356 KECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSP-DPCLNGGSCVDL-VGNYTCLC 413
Query: 325 PEGYSGPNCEIAEH----ACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI-DDCS 379
E + G CE +H ACLS PCHN G+C + G+ CEC G+ G C + DDC
Sbjct: 414 AEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE 473
Query: 380 PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDA-------------------------- 413
C +GG C N C CP + G C+ +
Sbjct: 474 ---CRNGGRCLG-ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLC 529
Query: 414 -------------NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD-ININDCL-GQC 458
+ C++ PC N SC SY C+C G+ G++C+ + C G C
Sbjct: 530 VCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPC 589
Query: 459 QNDASCRDLVNGYRCICPPGYAGDHCE-RDIDECASNPCLNGGHCQNEINRFQCLCPTGF 517
+N +C++ Y C CP + G HCE D CAS PC NGG C + I +++C CP GF
Sbjct: 590 RNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGF 649
Query: 518 SGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDS 577
SG C++ C +PC NG C +R +D+FC C Y G+ C D P E +
Sbjct: 650 SGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVD---CGPPEEVKH 706
Query: 578 CT----------VAMASNDTPEGVRYISS-NVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
T VA+ + D + S VC PHG C
Sbjct: 707 ATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPP---------------QC 751
Query: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 686
E I++C S PC +GG+C D V Y C+CS G+EGA+CE ++C +PC NGG+CR+L
Sbjct: 752 LE-IDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLP 810
Query: 687 NDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNS 746
+ C C G+ G C + CD + C +GG C G A+ C+CP + G C +
Sbjct: 811 GAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETV-SD 869
Query: 747 SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
C +PC G C+ + S +C CK G+ G CA+
Sbjct: 870 PCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK 904
Score = 325 bits (832), Expect = 2e-88
Identities = 208/651 (31%), Positives = 290/651 (44%), Gaps = 91/651 (13%)
Query: 383 CSHGGTC-QDLVNG---FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDC 438
C +GG C D V G + C C +TG+ C LD NEC ++PC N +C + I S+ C C
Sbjct: 278 CLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQC 337
Query: 439 LPGWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCL 497
G+ G C+ + C +CQ+ C+ C+C GY G CE D+D+C+ +PCL
Sbjct: 338 PAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL 397
Query: 498 NGGHCQNEINRFQCLCPTGFSGNLCQLDI----DYCEPNPCQNGAQCYNRASDYFCKCPE 553
NGG C + + + CLC F G C+ D C PC NG C + Y C+CPE
Sbjct: 398 NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPE 457
Query: 554 DYEGKNC-SHLKDHCR-----------TTPCEVIDSCTVAMASNDTPEGVRYISSNV--- 598
+ G +C + D C TT C+ C + + + N+
Sbjct: 458 GFMGLDCRERVPDDCECRNGGRCLGANTTLCQ----CPLGFFGLLCEFEITAMPCNMNTQ 513
Query: 599 CGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDG 658
C G C + GG + C C+ + H + C+S+PC NGG+C +SY C C G
Sbjct: 514 CPDGGYCM-EHGGSYLCVCHTDHNAS--HSLPSPCDSDPCFNGGSCDAHDDSYTCECPRG 570
Query: 659 WEGAYCE-TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCH-SRDSQCDEATCNN 716
+ G +CE + CS PC NGGTC++ +++C C + G+ C + C C+N
Sbjct: 571 FHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHN 630
Query: 717 GGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEG 776
GGTC+ +KC CP G+ G C IA S C +PC NGGTC F C C+ G+ G
Sbjct: 631 GGTCFHYIGKYKCDCPPGFSGRHCEIAP-SPCFRSPCVNGGTCEDRDTDFFCHCQAGYMG 689
Query: 777 PICAQNTNDCSP-----HPCYN-SGTCVDGDNWYRCE-------------CAPG--FAGP 815
C Q DC P H +GT + Y C+ C P ++ P
Sbjct: 690 RRC-QAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEP 748
Query: 816 DCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ----EVSGRPCITMGSV-- 869
+ I+EC+S PC G +C D + GY C+C G+ GA C+ E PC GS
Sbjct: 749 PQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRN 808
Query: 870 IPDGAKWDDDCNTCQCLNGRIA--CSKVW--CGPRPCLLHKGHSE---------CPS--- 913
+P C+C G + C C PC H G E CP
Sbjct: 809 LPGAY-------VCRCPAGFVGVHCETEVDACDSSPCQ-HGGRCESGGGAYLCVCPESFF 860
Query: 914 GQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSD-SYYQDNCANITF 963
G C + D CF PC G G C +S+ CT Y ++CA F
Sbjct: 861 GYHCETV-SDPCFSSPCGGRGYCLASN---GSHSCTCKVGYTGEDCAKELF 907
Score = 315 bits (807), Expect = 2e-85
Identities = 186/563 (33%), Positives = 250/563 (44%), Gaps = 73/563 (12%)
Query: 419 KPCVNAKSCKNLIA----SYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRC 473
+PC+N C + SY C CL G+ G+ C +++N+C Q CQN +C +N +RC
Sbjct: 276 RPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRC 335
Query: 474 ICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNP 533
CP G+ G CE C + C +GG CQ E C+C G++G C++D+D C P+P
Sbjct: 336 QCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDP 395
Query: 534 CQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRY 593
C NG C + +Y C C E ++G C DH V D+C A N
Sbjct: 396 CLNGGSCVDLVGNYTCLCAEPFKGLRCE-TGDH------PVPDACLSAPCHNG------- 441
Query: 594 ISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENI-NDCESNPCRNGGTCIDGVNSYK 652
G C G + C+C +GF G C E + +DCE CRNGG C+ G N+
Sbjct: 442 ---------GTCVDADQG-YVCECPEGFMGLDCRERVPDDCE---CRNGGRCL-GANTTL 487
Query: 653 CICSDGWEGAYCETNIN--DCSQNP-CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQC 709
C C G+ G CE I C+ N C +GG C + + C C HS S C
Sbjct: 488 CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNAS--HSLPSPC 545
Query: 710 DEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCV 769
D C NGG+C D++ C CP G+ G C AR C PC NGGTC G + C
Sbjct: 546 DSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCS 605
Query: 770 CKEGWEGPICAQNTND-CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP 828
C + G C D C+ PC+N GTC Y+C+C PGF+G C I + C SP
Sbjct: 606 CPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSP 665
Query: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQ---------EVSGRPCITMGSVIPDGAKWDDD 879
C G TC D + C C G+ G +CQ EV G+ + A + D
Sbjct: 666 CVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACD 725
Query: 880 CNTCQCLNGRIACSK---VWCGPRPCL----------LHKGHSE---------CPSGQ-- 915
RI + VW P CL LH G + C +G
Sbjct: 726 RGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEG 785
Query: 916 SCIPILDDQCFVHPCTGVGECRS 938
+ + D+C HPC G CR+
Sbjct: 786 AHCELERDECRAHPCRNGGSCRN 808
Score = 256 bits (654), Expect = 9e-68
Identities = 150/498 (30%), Positives = 213/498 (42%), Gaps = 119/498 (23%)
Query: 213 DQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGD---CRCQYGWQGLYCD---KCI 266
DQ C EG+MG +C + C ++G L + C+C G+ GL C+ +
Sbjct: 448 DQGYVCECPEGFMGLDCRERV-PDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAM 506
Query: 267 PHPGCVHGICNEPWQC----LCETNWGGQLCDKDLNYCGTH--------QPCLNGGTCSN 314
P CN QC C + G LC ++ +H PC NGG+C +
Sbjct: 507 P--------CNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSC-D 557
Query: 315 TGPDKYQCSCPEGYSGPNCEIAE-HACLSDPCHNRGSCKETSLGFECECSPGWTGPTCST 373
D Y C CP G+ G +CE A H C S PC N G+CKE + C C +TG C
Sbjct: 558 AHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEI 617
Query: 374 -NIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIA 432
D C+ C +GGTC + +KC CPP ++G+ C++ + C PCVN +C++
Sbjct: 618 GKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDT 677
Query: 433 SYYCDCLPGWMGQNCDININDC-----------------LG------------------- 456
++C C G+MG+ C + DC LG
Sbjct: 678 DFFCHCQAGYMGRRCQAEV-DCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRI 736
Query: 457 -------------QCQNDASCR-----------DLVNGYRCICPPGYAGDHCERDIDECA 492
QC CR D V GY C+C GY G HCE + DEC
Sbjct: 737 RVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECR 796
Query: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCP 552
++PC NGG C+N + C CP GF G C+ ++D C+ +PCQ+G +C + Y C CP
Sbjct: 797 AHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCP 856
Query: 553 EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK 612
E + G +C + D C ++P CG G C + S G
Sbjct: 857 ESFFGYHCETVSDPCFSSP---------------------------CGGRGYCLA-SNGS 888
Query: 613 FTCDCNKGFTGTYCHENI 630
+C C G+TG C + +
Sbjct: 889 HSCTCKVGYTGEDCAKEL 906
Score = 49.7 bits (117), Expect = 2e-05
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 11/70 (15%)
Query: 632 DCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETN-----------INDCSQNPCHNGG 680
+C NPC+NGGTC+ G +++ C C G++G CE ++ P GG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 681 TCRDLVNDFY 690
C + Y
Sbjct: 1370 VCHHVYKRVY 1379
Score = 48.1 bits (113), Expect = 5e-05
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 785 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPC 829
+CS +PC N GTCV G + + C+C PGF G C + + S PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 46.2 bits (108), Expect = 2e-04
Identities = 27/72 (37%), Positives = 33/72 (45%), Gaps = 14/72 (19%)
Query: 302 THQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKETSLGFE 359
+ PC NGGTC G D + C C G+ G CE+ AC+ S PC T L E
Sbjct: 1312 SENPCQNGGTCV-PGADAHSCDCGPGFKGRRCEL---ACIKVSRPC--------TRLFSE 1359
Query: 360 CECSPGWTGPTC 371
+ P W G C
Sbjct: 1360 TKAFPVWEGGVC 1371
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 670 DCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEAT--CNNGGTCYDEGDAF 727
+CS+NPC NGGTC + CDC G+KG+ C + C + + C + E AF
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRC---ELACIKVSRPCTR---LFSETKAF 1363
Query: 728 KCMCPGGWEGTTCN 741
WEG C+
Sbjct: 1364 PV-----WEGGVCH 1372
Score = 41.6 bits (96), Expect = 0.005
Identities = 15/33 (45%), Positives = 21/33 (63%)
Query: 747 SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
+C NPC NGGTCV ++ +C C G++G C
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342
Score = 41.2 bits (95), Expect = 0.006
Identities = 16/35 (45%), Positives = 19/35 (54%)
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA 743
C E C NGGTC DA C C G++G C +A
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA 1345
Score = 40.0 bits (92), Expect = 0.014
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 482 DHCERDIDE----CASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQL 524
+H +DI C+ NPC NGG C + C C GF G C+L
Sbjct: 1298 EHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 40.0 bits (92), Expect = 0.014
Identities = 18/57 (31%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 824 CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS---GRPCITMGSVIPDGAKWD 877
C +PC G TCV + + C C PG G +C+ RPC + S W+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWE 1367
Score = 38.9 bits (89), Expect = 0.030
Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 377 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVN-AKSCKNLIASYY 435
+CS N C +GGTC + C C P + G+ C+L C+ ++ C L +
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL--------ACIKVSRPCTRLFSE-- 1359
Query: 436 CDCLPGWMGQNC 447
P W G C
Sbjct: 1360 TKAFPVWEGGVC 1371
Score = 37.7 bits (86), Expect = 0.067
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
C NPCQNG C A + C C ++G+ C
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342
Score = 35.4 bits (80), Expect = 0.33
Identities = 12/32 (37%), Positives = 17/32 (53%)
Query: 340 CLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
C +PC N G+C + C+C PG+ G C
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342
Score = 35.0 bits (79), Expect = 0.44
Identities = 12/34 (35%), Positives = 19/34 (55%)
Query: 416 CEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449
C PC N +C ++ CDC PG+ G+ C++
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 33.1 bits (74), Expect = 1.7
Identities = 18/62 (29%), Positives = 24/62 (38%), Gaps = 11/62 (17%)
Query: 458 CQNDASCRDLVNGYRCICPPGYAGDHCE-----------RDIDECASNPCLNGGHCQNEI 506
CQN +C + + C C PG+ G CE R E + P GG C +
Sbjct: 1316 CQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVY 1375
Query: 507 NR 508
R
Sbjct: 1376 KR 1377
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 293 bits (749), Expect = 9e-79
Identities = 154/509 (30%), Positives = 227/509 (44%), Gaps = 72/509 (14%)
Query: 409 CQLDANECEAKPCVNAKSCKNLIASYYCDC--LPGWMGQNCDININDCLGQ-CQNDASCR 465
C + C + C N +CK+ C C + ++CD + C CQ A+C
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 466 DLVN--GYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ 523
+ + C CPPGY+G CE I C N C +GG C + C+CP G++G C+
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 524 LDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMA 583
+D D C +PCQNGA C + Y C C Y+G++C D C + PC+ +C +
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEI- 205
Query: 584 SNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGT 643
G++TC C ++G C I++C S PC NG T
Sbjct: 206 ---------------------------GRYTCICPHNYSGVNCELEIDECWSQPCLNGAT 238
Query: 644 CIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCK-NGWKGKTC 702
C D + +Y C C+ G+ G +CE N ++C+ PC +GG C D N + C+C +G+ G C
Sbjct: 239 CQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298
Query: 703 HSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVV- 761
+ C C+N TC D D + C C G+ G C I N C NPC + G CV
Sbjct: 299 ETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNE-CNSNPCQSNGECVEL 357
Query: 762 -------------------NGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
+ C+C+ G+ G C ++ N+CS +PC N GTC +
Sbjct: 358 SSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPG 417
Query: 803 WYRCECA------PGFAGPDCRININECQSSPCAFGATCV----DEINGYRCVCPPGHSG 852
Y C C + G DC + C C TC+ D +G+ C+CP G++G
Sbjct: 418 NYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTG 477
Query: 853 AKCQ-------EVSGRPCITMGSVIPDGA 874
+ C+ E G + GSV G+
Sbjct: 478 SLCEIATTLSFEGDGFLWVKSGSVTTKGS 506
Score = 278 bits (710), Expect = 3e-74
Identities = 154/497 (30%), Positives = 224/497 (45%), Gaps = 98/497 (19%)
Query: 333 CEIAEHACLSDPCHNRGSCKETS------------------------------------- 355
C CLS+ C N +CK+ S
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 356 -----LGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQ 410
F C+C PG++G C T I C N+C HGG C C+CP + G+ C+
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 411 LDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVN 469
+D +EC + PC N C++ I Y C C+PG+ G++CD+ +++C C+N+A+C + +
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206
Query: 470 GYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYC 529
Y CICP Y+G +CE +IDEC S PCLNG CQ+ + + C C GF G+ C+L+ D C
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDEC 266
Query: 530 EPNPCQNGAQCYNRASDYFCKCP-EDYEGKNCSHLKDHCRTTPC-------EVIDS---- 577
PC +G C + + Y C C + G +C L C + PC + +D+
Sbjct: 267 ASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCH 326
Query: 578 CTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK-------------------FTCDCN 618
C + +SN C +G+C S K + C C
Sbjct: 327 CWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQ 386
Query: 619 KGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC------SDGWEGAYCETNINDCS 672
GFTG +C E++N+C SNPC+NGGTC + +Y C C + G C + C+
Sbjct: 387 PGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCT 446
Query: 673 QNPCHNGGTC----RDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFK 728
C N GTC +D + F C C +G+ G S C+ AT T EGD F
Sbjct: 447 HQQCLNNGTCIPHFQDGQHGFSCLCPSGYTG-------SLCEIAT-----TLSFEGDGFL 494
Query: 729 CMCPGG--WEGTTCNIA 743
+ G +G+ CNIA
Sbjct: 495 WVKSGSVTTKGSVCNIA 511
Score = 271 bits (694), Expect = 2e-72
Identities = 138/482 (28%), Positives = 217/482 (45%), Gaps = 76/482 (15%)
Query: 230 NRAICRQGCSPKHGSCK---LPGDCRCQYGWQGLY--CDK----CIPHP-----GCVHGI 275
N C + +CK DC C L CD C +P CV+
Sbjct: 30 NNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTP 89
Query: 276 CNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
+ C C + G +C+ + CG + C +GG C + P C CP GY+G CEI
Sbjct: 90 GERSFLCKCPPGYSGTICETTIGSCGKNS-CQHGGIC-HQDPIYPVCICPAGYAGRFCEI 147
Query: 336 AEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG 395
C S PC N C++ G+ C C PG+ G C +D+C+ + C + TC + +
Sbjct: 148 DHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGR 207
Query: 396 FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCL 455
+ C+CP ++G C+L+ +EC ++PC+N +C++ + +Y+CDC PG++G +C++N ++C
Sbjct: 208 YTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECA 267
Query: 456 GQ-CQNDASCRDLVNGYRCICP-PGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC 513
Q C + C D N Y C C G+ G HCE + C S PC N C++ ++ + C C
Sbjct: 268 SQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHC 327
Query: 514 PTGFSGNLCQLDIDYCEPNPCQNGAQC--------------------YNRASDYFCKCPE 553
G++G C++D++ C NPCQ+ +C Y+ AS Y C C
Sbjct: 328 WPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQP 387
Query: 554 DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKF 613
+ G +C + C + PC+ +C G +
Sbjct: 388 GFTGIHCEEDVNECSSNPCQNGGTC----------------------------ENLPGNY 419
Query: 614 TCDC------NKGFTGTYCHENINDCESNPCRNGGTCI----DGVNSYKCICSDGWEGAY 663
TC C + G C + + C C N GTCI DG + + C+C G+ G+
Sbjct: 420 TCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSL 479
Query: 664 CE 665
CE
Sbjct: 480 CE 481
Score = 248 bits (633), Expect = 3e-65
Identities = 136/453 (30%), Positives = 197/453 (43%), Gaps = 64/453 (14%)
Query: 520 NLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEG--KNCSHLKDHCRTTPCEVIDS 577
+ C + C N CQN + C + + D C C + K+C ++KD C + PC+ +
Sbjct: 25 SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 578 CTVAMASND----TPEGVR-YISSNVCGPHGKCKSQSGGKF-------TCDCNKGFTGTY 625
C P G I G GK Q GG C C G+ G +
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Query: 626 CHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDL 685
C + ++C S+PC+NG C DG++ Y C C G++G +C+ +++C+ +PC N TC +
Sbjct: 145 CEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNE 204
Query: 686 VNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARN 745
+ + C C + + G C +C C NG TC D A+ C C G+ G C +
Sbjct: 205 IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCEL-NT 263
Query: 746 SSCLPNPCHNGGTCVVNGESFTCVCK-EGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
C PC +GG CV ++C C G+ G C C PC+N+ TC D + Y
Sbjct: 264 DECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNY 323
Query: 805 RCECAPGFAGPDCRININECQSSPCAFGATCVD--------------------EINGYRC 844
C C PG+ G C I++NEC S+PC CV+ E +GY C
Sbjct: 324 TCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVC 383
Query: 845 VCPPGHSGAKCQ----EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIAC-------S 893
+C PG +G C+ E S PC G TC+ L G C S
Sbjct: 384 ICQPGFTGIHCEEDVNECSSNPCQNGG--------------TCENLPGNYTCHCPFDNLS 429
Query: 894 KVWCGPRPC---LLHKGHSECPSGQSCIPILDD 923
+ + G R C LL H +C + +CIP D
Sbjct: 430 RTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQD 462
Score = 219 bits (559), Expect = 1e-56
Identities = 121/388 (31%), Positives = 179/388 (46%), Gaps = 86/388 (22%)
Query: 220 CMEGWMGPECNRAI--CRQGCSPKHGSCK---LPGDCRCQYGWQGLYC----DKCIPHPG 270
C G+ G C I C + G C + C C G+ G +C D+C P
Sbjct: 98 CPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSP- 156
Query: 271 CVHG-ICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPE 326
C +G +C + + C C + G+ CD +++ C + PC N TC N +Y C CP
Sbjct: 157 CQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECAS-DPCKNEATCLNE-IGRYTCICPH 214
Query: 327 GYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHG 386
YSG NCE+ C S PC N +C++ + C+C+PG+ G C N D+C+ C HG
Sbjct: 215 NYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHG 274
Query: 387 GTCQDLVNGFKCVCPPQ-WTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQ 445
G C D N + C C +TG C+ C +KPC N +C++ + +Y C C PG+ G
Sbjct: 275 GLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGA 334
Query: 446 NCDININDCLGQ-CQNDASCRDL--------------------VNGYRCICPPGYAGDHC 484
C+I++N+C CQ++ C +L +GY CIC PG+ G HC
Sbjct: 335 QCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHC 394
Query: 485 ERDIDECASNPCLNGGHCQN------------EINR------------------------ 508
E D++EC+SNPC NGG C+N ++R
Sbjct: 395 EEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNG 454
Query: 509 ------------FQCLCPTGFSGNLCQL 524
F CLCP+G++G+LC++
Sbjct: 455 TCIPHFQDGQHGFSCLCPSGYTGSLCEI 482
Score = 188 bits (477), Expect = 3e-47
Identities = 95/331 (28%), Positives = 146/331 (44%), Gaps = 19/331 (5%)
Query: 624 TYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG--AYCETNINDCSQNPCHNGGT 681
++C++N C SN C+N TC D C CSD C+ + C NPC T
Sbjct: 25 SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 682 CRDLVND--FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTT 739
C + + F C C G+ G C + C + +C +GG C+ + C+CP G+ G
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Query: 740 CNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVD 799
C I + C +PC NG C + ++C C G++G C ++C+ PC N TC++
Sbjct: 145 CEI-DHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLN 203
Query: 800 GDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ--- 856
Y C C ++G +C + I+EC S PC GATC D + Y C C PG G C+
Sbjct: 204 EIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNT 263
Query: 857 -EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQ 915
E + +PC+ G + ++ +C C +PC + +
Sbjct: 264 DECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNY 323
Query: 916 SC----------IPILDDQCFVHPCTGVGEC 936
+C I ++C +PC GEC
Sbjct: 324 TCHCWPGYTGAQCEIDLNECNSNPCQSNGEC 354
Score = 165 bits (418), Expect = 2e-40
Identities = 71/195 (36%), Positives = 109/195 (55%), Gaps = 47/195 (24%)
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
C+ N C HGG C+D+ + + C CP W+GK C+L+ +EC + PC++ +C + +A+Y+C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVAAYHCT 1201
Query: 438 CLPGWMGQNCDININDCLG-QCQNDASCRDLVNGY------------------------- 471
C PG+ G NC+++I++C QC N A+C NGY
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261
Query: 472 --------------------RCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQC 511
+C+C PG+ G+ CE+DIDECAS+PC+NGG CQ+ +N+FQC
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQC 1321
Query: 512 LCPTGFSGNLCQLDI 526
LC F+G C++D+
Sbjct: 1322 LCDVAFAGERCEVDL 1336
Score = 161 bits (407), Expect = 4e-39
Identities = 71/198 (35%), Positives = 102/198 (51%), Gaps = 7/198 (3%)
Query: 630 INDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689
+N C SNPC +GG C D +SY C C GW G +CE NI++C NPC +G C D V +
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAY 1198
Query: 690 YCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCL 749
+C C+ G+ G C C C NG TC + + C+C G + G C +R S +
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258
Query: 750 PN------PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW 803
C+NGG C C+C+ G+ G C ++ ++C+ PC N G C D N
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318
Query: 804 YRCECAPGFAGPDCRINI 821
++C C FAG C +++
Sbjct: 1319 FQCLCDVAFAGERCEVDL 1336
Score = 160 bits (406), Expect = 5e-39
Identities = 91/310 (29%), Positives = 128/310 (41%), Gaps = 39/310 (12%)
Query: 660 EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKG--KTCHSRDSQCDEATCNNG 717
+ ++C N C N C N TC+D D C C + K C + C C
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGS 82
Query: 718 GTCYDEGD--AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE 775
TC + +F C CP G+ GT C SC N C +GG C + C+C G+
Sbjct: 83 ATCVNTPGERSFLCKCPPGYSGTICE-TTIGSCGKNSCQHGGICHQDPIYPVCICPAGYA 141
Query: 776 GPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATC 835
G C + ++C+ PC N C DG + Y C C PG+ G C + ++EC S PC ATC
Sbjct: 142 GRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATC 201
Query: 836 VDEINGYRCVCPPGHSGAKCQ-EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNG---RIA 891
++EI Y C+CP +SG C+ E+ D+C + CLNG + A
Sbjct: 202 LNEIGRYTCICPHNYSGVNCELEI-------------------DECWSQPCLNGATCQDA 242
Query: 892 CSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSD 951
+C P L G C + D+C PC G C CT
Sbjct: 243 LGAYFCDCAPGFL---------GDHC-ELNTDECASQPCLHGGLCVDGE-NRYSCNCTGS 291
Query: 952 SYYQDNCANI 961
+ +C +
Sbjct: 292 GFTGTHCETL 301
Score = 158 bits (399), Expect = 3e-38
Identities = 74/223 (33%), Positives = 120/223 (53%), Gaps = 23/223 (10%)
Query: 449 ININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEIN 507
+ +N C C + +C D+ + Y C CP G++G HCE +IDEC SNPC++G +C + +
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVA 1196
Query: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC 567
+ C C G++G C++DID C+ + C NGA C + + Y C C ++ GK C +
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCR--QSRL 1254
Query: 568 RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
+T C N+ ++ C G C ++ + C C GFTG +C
Sbjct: 1255 PSTVC-----------GNEK-------TNLTCYNGGNC-TEFQTELKCMCRPGFTGEWCE 1295
Query: 628 ENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIND 670
++I++C S+PC NGG C D +N ++C+C + G CE ++ D
Sbjct: 1296 KDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338
Score = 153 bits (386), Expect = 1e-36
Identities = 75/222 (33%), Positives = 113/222 (50%), Gaps = 36/222 (16%)
Query: 488 IDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDY 547
++ C SNPCL+GG+C++ + + C CP G+SG C+L+ID C NPC +G C +R + Y
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVAAY 1198
Query: 548 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS 607
C C Y G NC D+C+ S+ C C S
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQ---------------------------SHQCANGATCIS 1231
Query: 608 QSGGKFTCDCNKGFTGTYCHENI-------NDCESNPCRNGGTCIDGVNSYKCICSDGWE 660
+ G ++C C FTG +C ++ N+ + C NGG C + KC+C G+
Sbjct: 1232 HTNG-YSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFT 1290
Query: 661 GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
G +CE +I++C+ +PC NGG C+DL+N F C C + G+ C
Sbjct: 1291 GEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERC 1332
Score = 152 bits (384), Expect = 2e-36
Identities = 65/196 (33%), Positives = 100/196 (51%), Gaps = 9/196 (4%)
Query: 668 INDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAF 727
+N C+ NPC +GG C D+ + ++C C GW GK C +C C +G C D A+
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAY 1198
Query: 728 KCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNT---- 783
C C G+ G C + ++ C + C NG TC+ + ++C+C + G C Q+
Sbjct: 1199 HCTCEPGYTGVNCEVDIDN-CQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPST 1257
Query: 784 ---NDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEIN 840
N+ + CYN G C + +C C PGF G C +I+EC S PC G C D +N
Sbjct: 1258 VCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLN 1317
Query: 841 GYRCVCPPGHSGAKCQ 856
++C+C +G +C+
Sbjct: 1318 KFQCLCDVAFAGERCE 1333
Score = 135 bits (341), Expect = 2e-31
Identities = 68/229 (29%), Positives = 101/229 (44%), Gaps = 35/229 (15%)
Query: 411 LDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNG 470
L N C + PC++ +C+++ +SY+C C GW G++C++NI++C +C D V
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAA 1197
Query: 471 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC---QLDID 527
Y C C PGY G +CE DID C S+ C NG C + N + CLC F+G C +L
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPST 1257
Query: 528 YCEPN----PCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMA 583
C C NG C ++ C C + G+ C D C + PC
Sbjct: 1258 VCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPC----------- 1306
Query: 584 SNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND 632
++ +C KF C C+ F G C ++ D
Sbjct: 1307 ----------VNGGLC-------QDLLNKFQCLCDVAFAGERCEVDLAD 1338
Score = 132 bits (333), Expect = 2e-30
Identities = 70/202 (34%), Positives = 107/202 (52%), Gaps = 27/202 (13%)
Query: 229 CNRAICRQGCSPKHGSCK---LPGDCRCQYGWQGLYC----DKCIPHPGCVHGICNE--- 278
CN C G G+C+ C C GW G +C D+C +P C+HG C++
Sbjct: 1143 CNSNPCLHG-----GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVA 1196
Query: 279 PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTC-SNTGPDKYQCSCPEGYSGPNC---E 334
+ C CE + G C+ D++ C +HQ C NG TC S+T + Y C C ++G C
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQ-CANGATCISHT--NGYSCLCFGNFTGKFCRQSR 1253
Query: 335 IAEHACLSD----PCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ 390
+ C ++ C+N G+C E +C C PG+TG C +ID+C+ + C +GG CQ
Sbjct: 1254 LPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQ 1313
Query: 391 DLVNGFKCVCPPQWTGKTCQLD 412
DL+N F+C+C + G+ C++D
Sbjct: 1314 DLLNKFQCLCDVAFAGERCEVD 1335
Score = 132 bits (331), Expect = 3e-30
Identities = 71/232 (30%), Positives = 108/232 (46%), Gaps = 52/232 (22%)
Query: 272 VHGICNEPWQ---CLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY 328
VHG N+P + TN C LN C ++ PCL+GG C + Y CSCP G+
Sbjct: 1113 VHGFINKPQEEQFLKISTNSVVTGC-LQLNVCNSN-PCLHGGNCEDIY-SSYHCSCPLGW 1169
Query: 329 SGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT 388
SG +CE+ C S+PC + G+C + + C C PG+TG C +ID+C + C++G T
Sbjct: 1170 SGKHCELNIDECFSNPCIH-GNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGAT 1228
Query: 389 CQDLVNGF---------------------------------------------KCVCPPQ 403
C NG+ KC+C P
Sbjct: 1229 CISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPG 1288
Query: 404 WTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCL 455
+TG+ C+ D +EC + PCVN C++L+ + C C + G+ C++++ D L
Sbjct: 1289 FTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 129 bits (323), Expect = 2e-29
Identities = 67/198 (33%), Positives = 92/198 (46%), Gaps = 10/198 (5%)
Query: 595 SSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCI 654
+SN C G C+ + C C G++G +C NI++C SNPC +G C D V +Y C
Sbjct: 1144 NSNPCLHGGNCEDIYSS-YHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAYHCT 1201
Query: 655 CSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSR-------DS 707
C G+ G CE +I++C + C NG TC N + C C + GK C +
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261
Query: 708 QCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFT 767
+ TC NGG C + KCMC G+ G C C +PC NGG C F
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCE-KDIDECASDPCVNGGLCQDLLNKFQ 1320
Query: 768 CVCKEGWEGPICAQNTND 785
C+C + G C + D
Sbjct: 1321 CLCDVAFAGERCEVDLAD 1338
Score = 108 bits (270), Expect = 3e-23
Identities = 62/190 (32%), Positives = 89/190 (46%), Gaps = 19/190 (10%)
Query: 748 CLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCE 807
C NPC +GG C S+ C C GW G C N ++C +PC + G C D Y C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAAYHCT 1201
Query: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMG 867
C PG+ G +C ++I+ CQS CA GATC+ NGY C+C +G C++ S P G
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ-SRLPSTVCG 1260
Query: 868 SVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFV 927
++ C NG C++ + C+ G +G+ C + D+C
Sbjct: 1261 ----------NEKTNLTCYNGG-NCTEFQTELK-CMCRPGF----TGEWCEKDI-DECAS 1303
Query: 928 HPCTGVGECR 937
PC G C+
Sbjct: 1304 DPCVNGGLCQ 1313
Score = 65.1 bits (157), Expect = 4e-10
Identities = 51/175 (29%), Positives = 70/175 (40%), Gaps = 50/175 (28%)
Query: 204 DDFFGHYACDQNGNKTCMEGWMGPECNRAI--CRQGCSPKHGSCK-------------LP 248
+D +Y C C G+ G +C + C +G C LP
Sbjct: 317 EDSVDNYTCH------CWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLP 370
Query: 249 GD----------CRCQYGWQGLYCDK----CIPHPGCVHG----------ICNEPWQCLC 284
C CQ G+ G++C++ C +P C +G C+ P+ L
Sbjct: 371 SSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNP-CQNGGTCENLPGNYTCHCPFDNLS 429
Query: 285 ETNWGGQLCDKDLNYCGTHQPCLNGGTCS---NTGPDKYQCSCPEGYSGPNCEIA 336
T +GG+ C L C THQ CLN GTC G + C CP GY+G CEIA
Sbjct: 430 RTFYGGRDCSDILLGC-THQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA 483
Score = 58.9 bits (141), Expect = 3e-08
Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 478 GYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNG 537
G AGD+ C SNPC NGG C + + F C CP SG C+ ++ +C +PC +G
Sbjct: 884 GCAGDN------SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHG 936
Query: 538 AQCYNRASDYFCKCPEDYEGKN 559
AQC + C + G++
Sbjct: 937 AQCQPVLQGFECIANAVFNGQS 958
Score = 57.8 bits (138), Expect = 6e-08
Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 337 EHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGF 396
+++C S+PCHN G C F C C +G C + C + C HG CQ ++ GF
Sbjct: 888 DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGF 946
Query: 397 KCVCPPQWTGKTCQL 411
+C+ + G++ Q+
Sbjct: 947 ECIANAVFNGQSGQI 961
Score = 54.7 bits (130), Expect = 5e-07
Identities = 26/79 (32%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFK 728
N C NPCHNGG C +DF C C GK C C + C +G C F+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 729 CMCPGGWEGTTCNIARNSS 747
C+ + G + I S+
Sbjct: 948 CIANAVFNGQSGQILFRSN 966
Score = 53.5 bits (127), Expect = 1e-06
Identities = 23/71 (32%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 631 NDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFY 690
N C+SNPC NGG C + + C C G CE + C +PC +G C+ ++ F
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 691 CDCKNGWKGKT 701
C + G++
Sbjct: 948 CIANAVFNGQS 958
Score = 49.7 bits (117), Expect = 2e-05
Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 12/113 (10%)
Query: 744 RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW 803
+N PNP +N S V +G CA + N C +PC+N G C +
Sbjct: 860 QNLEFFPNPTNNA--------SLNPVLVNVTQG--CAGD-NSCKSNPCHNGGVCHSRWDD 908
Query: 804 YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
+ C C +G C + C SPC GA C + G+ C+ +G Q
Sbjct: 909 FSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQ 960
Score = 48.9 bits (115), Expect = 3e-05
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Query: 706 DSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES 765
D+ C C+NGG C+ D F C CP G C + C +PC +G C +
Sbjct: 888 DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ--WCGFSPCPHGAQCQPVLQG 945
Query: 766 FTCVCKEGWEG 776
F C+ + G
Sbjct: 946 FECIANAVFNG 956
Score = 48.1 bits (113), Expect = 5e-05
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYY 435
+ C N C +GG C + F C CP +GK C+ + C PC + C+ ++ +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 436 CDCLPGWMGQNCDI 449
C + GQ+ I
Sbjct: 948 CIANAVFNGQSGQI 961
Score = 48.1 bits (113), Expect = 5e-05
Identities = 52/182 (28%), Positives = 65/182 (35%), Gaps = 50/182 (27%)
Query: 819 ININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ----EVSGRPCITMGSVIPDGA 874
+ +N C S+PC G C D + Y C CP G SG C+ E PCI G+ A
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCI-HGNCSDRVA 1196
Query: 875 KWD----------------DDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCI 918
+ D+C + QC NG C+ H +G SC+
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANG-----------ATCISH------TNGYSCL 1239
Query: 919 PILDDQCFVHPCTGVGECRSSSLQPV---KTKCTSDSYYQDNCANITFTFNKEMMSPGLT 975
CF + TG CR S L K Y NC T K M PG T
Sbjct: 1240 ------CFGN-FTG-KFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQ-TELKCMCRPGFT 1290
Query: 976 TE 977
E
Sbjct: 1291 GE 1292
Score = 47.0 bits (110), Expect = 1e-04
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 2/74 (2%)
Query: 452 NDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQ 510
N C C N C + + C CP +G CE ++ C +PC +G CQ + F+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 511 CLCPTGFSGNLCQL 524
C+ F+G Q+
Sbjct: 948 CIANAVFNGQSGQI 961
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/71 (36%), Positives = 35/71 (49%), Gaps = 3/71 (4%)
Query: 298 NYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG 357
N C ++ PC NGG C + D + CSCP SG CE + C PC + C+ G
Sbjct: 889 NSCKSN-PCHNGGVCHSRWDD-FSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQG 945
Query: 358 FECECSPGWTG 368
FEC + + G
Sbjct: 946 FECIANAVFNG 956
Score = 47.0 bits (110), Expect = 1e-04
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C+ NPC NG C++R D+ C CP GK C ++ C +PC C +
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ-WCGFSPCPHGAQCQPVL------ 943
Query: 589 EGVRYISSNVC-GPHGKCKSQSGGKFT 614
+G I++ V G G+ +S G T
Sbjct: 944 QGFECIANAVFNGQSGQILFRSNGNIT 970
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/34 (47%), Positives = 19/34 (55%)
Query: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
D+CE PCQ+ +C N Y C C YEG NC
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 38.5 bits (88), Expect = 0.039
Identities = 25/100 (25%), Positives = 31/100 (31%), Gaps = 45/100 (45%)
Query: 822 NECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCN 881
N C+S+PC G C + + C CP SG C+EV
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ---------------------- 926
Query: 882 TCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPIL 921
WC G S CP G C P+L
Sbjct: 927 --------------WC---------GFSPCPHGAQCQPVL 943
Score = 37.7 bits (86), Expect = 0.067
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 340 CLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
C S PC +RG C L ++C+C + GP C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 37.7 bits (86), Expect = 0.067
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 416 CEAKPCVNAKSCKNLIASYYCDCLPGWMGQNC 447
CE++PC + C NL SY CDC + G NC
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 37.0 bits (84), Expect = 0.11
Identities = 15/32 (46%), Positives = 20/32 (62%)
Query: 633 CESNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664
CES PC++ G CI+ SY+C C +EG C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 36.6 bits (83), Expect = 0.15
Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 9/92 (9%)
Query: 596 SNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC 655
SN C G C S+ F+C C +G C E + C +PC +G C + ++CI
Sbjct: 893 SNPCHNGGVCHSR-WDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECIA 950
Query: 656 SDGWEGAYCETNINDCSQNPCHNGGTCRDLVN 687
+ + G + NG R+L N
Sbjct: 951 NAVFNGQSGQILFRS-------NGNITRELTN 975
Score = 35.0 bits (79), Expect = 0.44
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 1/30 (3%)
Query: 304 QPCLNGGTCSNTGPDKYQCSCPEGYSGPNC 333
QPC + G C N YQC C Y GPNC
Sbjct: 679 QPCQSRGRCINLWLS-YQCDCHRPYEGPNC 707
Score = 33.1 bits (74), Expect = 1.7
Identities = 11/32 (34%), Positives = 16/32 (50%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
C PC + G C +L + CDC ++G C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 33.1 bits (74), Expect = 1.7
Identities = 11/32 (34%), Positives = 18/32 (56%)
Query: 786 CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC 817
C PC + G C++ Y+C+C + GP+C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 32.7 bits (73), Expect = 2.2
Identities = 15/47 (31%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 737 GTTCNI----ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
G++ N+ R C PC + G C+ S+ C C +EGP C
Sbjct: 661 GSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 281 bits (718), Expect = 3e-75
Identities = 141/431 (32%), Positives = 203/431 (47%), Gaps = 60/431 (13%)
Query: 267 PHPGCVHGICNEPWQCLCETNWGGQLCDK-DLNYCGTHQPCLNGGTCSNTGPDK--YQCS 323
P C C +C T GG C + C T QPC +G C GPD ++C
Sbjct: 38 PPSACASDPCAPGTECQA-TESGGYTCGPMEPRGCAT-QPCHHGALCVPQGPDPTGFRCY 95
Query: 324 CPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNC 383
C G+ GP CE+ C S PCH+ +C+ + +EC C G+ G TC +D+C+ C
Sbjct: 96 CVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPC 155
Query: 384 SHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCL-PGW 442
HGG+C D V F+CVC P + G CQLD +EC+++PC + +C +L+ + CDC G+
Sbjct: 156 LHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGY 215
Query: 443 MGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGH 501
G +C+ + +C C+++ASC + + +RC+C PGY+G+ CE D DECAS+PC +GG
Sbjct: 216 EGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGR 275
Query: 502 CQNEIN---------------------RFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC 540
C + F C CP GF G C +++D C PC NG C
Sbjct: 276 CLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHC 335
Query: 541 YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600
+ + + C CP+ Y G C D C + PC
Sbjct: 336 QDLPNGFQCHCPDGYAGPTCEEDVDECLSDPC---------------------------- 367
Query: 601 PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCI----DGVNSYKCICS 656
HG S + + C C + + G C + C+ + C TCI GV+SY C C
Sbjct: 368 LHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCP 427
Query: 657 DGWEGAYCETN 667
G G +C N
Sbjct: 428 PGTHGPFCGQN 438
Score = 280 bits (716), Expect = 6e-75
Identities = 144/437 (32%), Positives = 212/437 (48%), Gaps = 70/437 (16%)
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC-QLDANECEAKPCVNAKSCKNL---IAS 433
C+ + C+ G CQ +G G TC ++ C +PC + C
Sbjct: 42 CASDPCAPGTECQATESG----------GYTCGPMEPRGCATQPCHHGALCVPQGPDPTG 91
Query: 434 YYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
+ C C+PG+ G C+++I++C + C + A+CR+L + Y C CP GYAG CE ++DECA
Sbjct: 92 FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151
Query: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCP 552
S PCL+GG C + + F+C+C G+ G CQLD+D C+ PC +G C++ + + C C
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCA 211
Query: 553 -EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGG 611
YEG +C C + PCE SC EG+ G
Sbjct: 212 GTGYEGTHCEREVLECASAPCEHNASCL---------EGL-------------------G 243
Query: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCID---------------GVNSYK---- 652
F C C G++G C + ++C S+PC++GG C+ G S++
Sbjct: 244 SFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAG 303
Query: 653 --CICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCD 710
C C G+EGA C +++C+ PC NGG C+DL N F C C +G+ G TC +C
Sbjct: 304 FLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECL 363
Query: 711 EATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES----F 766
C +GGTC D + C CP W G C++ + + C + C TC+ ES +
Sbjct: 364 SDPCLHGGTCSDTVAGYICRCPETWGGRDCSV-QLTGCQGHTCPLAATCIPIFESGVHSY 422
Query: 767 TCVCKEGWEGPICAQNT 783
C C G GP C QNT
Sbjct: 423 VCHCPPGTHGPFCGQNT 439
Score = 265 bits (677), Expect = 2e-70
Identities = 131/394 (33%), Positives = 180/394 (45%), Gaps = 58/394 (14%)
Query: 491 CASNPCLNGGHCQNE---INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDY 547
CA+ PC +G C + F+C C GF G C+LDID C PC +GA C N A Y
Sbjct: 71 CATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRY 130
Query: 548 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS 607
C CP Y G C D C + PC SC +GV
Sbjct: 131 ECHCPLGYAGVTCEMEVDECASAPCLHGGSCL---------DGV---------------- 165
Query: 608 QSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSD-GWEGAYCET 666
G F C C G+ GT C ++++C+S PC +GGTC D VN ++C C+ G+EG +CE
Sbjct: 166 ---GSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCER 222
Query: 667 NINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD- 725
+ +C+ PC + +C + + F C C G+ G+ C + +C + C +GG C D
Sbjct: 223 EVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDP 282
Query: 726 --------------------AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES 765
F C CP G+EG C + + C PC NGG C
Sbjct: 283 ALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE-CASRPCLNGGHCQDLPNG 341
Query: 766 FTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQ 825
F C C +G+ GP C ++ ++C PC + GTC D Y C C + G DC + + CQ
Sbjct: 342 FQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQ 401
Query: 826 SSPCAFGATCV----DEINGYRCVCPPGHSGAKC 855
C ATC+ ++ Y C CPPG G C
Sbjct: 402 GHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 223 bits (568), Expect = 9e-58
Identities = 127/438 (28%), Positives = 186/438 (42%), Gaps = 91/438 (20%)
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C +PC G +C S + P + G C T PC
Sbjct: 42 CASDPCAPGTECQATESGGYTCGPMEPRG---------CATQPCH--------------- 77
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
+C P G + F C C GF G C +I++C S PC +G TC +
Sbjct: 78 ------HGALCVPQGPDPTG----FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLA 127
Query: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
+ Y+C C G+ G CE +++C+ PC +GG+C D V F C C G+ G C +
Sbjct: 128 DRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDE 187
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPG-GWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFT 767
C C +GGTC+D + F+C C G G+EGT C C PC + +C+ SF
Sbjct: 188 CQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE-REVLECASAPCEHNASCLEGLGSFR 246
Query: 768 CVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN---------------------WYRC 806
C+C G+ G +C + ++C+ PC + G C+ + + C
Sbjct: 247 CLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLC 306
Query: 807 ECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITM 866
C PGF G DC + ++EC S PC G C D NG++C CP G++G C+E
Sbjct: 307 HCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDV------- 359
Query: 867 GSVIPDGAKWDDDCNTCQCLNGRIA----------CSKVWCGPRPCLLH----KGHSECP 912
D+C + CL+G C + W G R C + +GH+ CP
Sbjct: 360 -----------DECLSDPCLHGGTCSDTVAGYICRCPETW-GGRDCSVQLTGCQGHT-CP 406
Query: 913 SGQSCIPILDDQCFVHPC 930
+CIPI + + C
Sbjct: 407 LAATCIPIFESGVHSYVC 424
Score = 199 bits (507), Expect = 1e-50
Identities = 107/343 (31%), Positives = 162/343 (47%), Gaps = 43/343 (12%)
Query: 220 CMEGWMGPECNRAICRQGCSPKH--GSCKLPGD---CRCQYGWQGLYC----DKCIPHPG 270
C+ G+ GP C I P H +C+ D C C G+ G+ C D+C P
Sbjct: 96 CVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAP- 154
Query: 271 CVH-GICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCP- 325
C+H G C + ++C+C +GG C DL+ C + QPC +GGTC + + ++C C
Sbjct: 155 CLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQS-QPCAHGGTCHDL-VNGFRCDCAG 212
Query: 326 EGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSH 385
GY G +CE C S PC + SC E F C C PG++G C + D+C+ + C H
Sbjct: 213 TGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQH 272
Query: 386 GGTCQDLVN---------------------GFKCVCPPQWTGKTCQLDANECEAKPCVNA 424
GG C + GF C CPP + G C ++ +EC ++PC+N
Sbjct: 273 GGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNG 332
Query: 425 KSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDH 483
C++L + C C G+ G C+ ++++CL C + +C D V GY C CP + G
Sbjct: 333 GHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRD 392
Query: 484 CERDIDECASNPCLNGGHC----QNEINRFQCLCPTGFSGNLC 522
C + C + C C ++ ++ + C CP G G C
Sbjct: 393 CSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 151 bits (382), Expect = 3e-36
Identities = 85/279 (30%), Positives = 127/279 (45%), Gaps = 49/279 (17%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ-CDEATCNNGGTCYDEGD---A 726
C+ +PC G C+ + Y TC + + C C++G C +G
Sbjct: 42 CASDPCAPGTECQATESGGY----------TCGPMEPRGCATQPCHHGALCVPQGPDPTG 91
Query: 727 FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDC 786
F+C C G++G C + + C PCH+G TC + + C C G+ G C ++C
Sbjct: 92 FRCYCVPGFQGPRCELDIDE-CASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150
Query: 787 SPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVC 846
+ PC + G+C+DG +RC CAPG+ G C+++++ECQS PCA G TC D +NG+RC C
Sbjct: 151 ASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDC 210
Query: 847 P-PGHSGAKCQ----EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRP 901
G+ G C+ E + PC + CL G G
Sbjct: 211 AGTGYEGTHCEREVLECASAPCE----------------HNASCLEG--------LGSFR 246
Query: 902 CLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940
CL G+ SG+ C + +D+C PC G C S
Sbjct: 247 CLCWPGY----SGELC-EVDEDECASSPCQHGGRCLQRS 280
Score = 107 bits (268), Expect = 5e-23
Identities = 48/151 (31%), Positives = 71/151 (47%), Gaps = 4/151 (2%)
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
C+P+ C H G C+DL + F C C P W G C+ + C + PC + + + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 438 CLPGWMGQNCDINI--NDCL--GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS 493
C PG+ G C + + +C C + + C C C G AG C+ C +
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 494 NPCLNGGHCQNEINRFQCLCPTGFSGNLCQL 524
NPCLNGG C+ +C+C FSG C++
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 102 bits (254), Expect = 2e-21
Identities = 52/152 (34%), Positives = 68/152 (44%), Gaps = 4/152 (2%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDA-FKC 729
C+ +PC + G CRDL + F C C GW+G C + C A C G C+ D F+C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFEC 1118
Query: 730 MCPGGWEGTTCNI-ARNSSCLPN-PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCS 787
CP G+ G C + + C N C +G C + C C EG G C T C
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 788 PHPCYNSGTCVDGDNWYRCECAPGFAGPDCRI 819
+PC N GTC C C F+G C +
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 100 bits (250), Expect = 6e-21
Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 6/151 (3%)
Query: 340 CLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG-FKC 398
C PC + G+C++ F C C PGW GP C ++D C C+ G C +G F+C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFEC 1118
Query: 399 VCPPQWTGKTCQL--DANECEAK-PCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC- 454
CPP + G C+L + EC C++ C+ + C CL G GQ C + C
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 455 LGQCQNDASCRDLVNGYRCICPPGYAGDHCE 485
C N +CR CIC ++G CE
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 99.4 bits (246), Expect = 2e-20
Identities = 48/153 (31%), Positives = 70/153 (45%), Gaps = 4/153 (2%)
Query: 416 CEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNG-YRCI 474
C PC++ +C++L ++ C C PGW G C+ +++ C C +G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 475 CPPGYAGDHCERDID--ECASN-PCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP 531
CPPG+ G C + EC+ N CL+G C+ C C G +G CQ+ CE
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 532 NPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLK 564
NPC NG C C C + G+ C K
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 99.0 bits (245), Expect = 2e-20
Identities = 49/150 (32%), Positives = 63/150 (42%), Gaps = 4/150 (2%)
Query: 633 CESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCD 692
C +PC + G C D +++ C C GWEG CE +++ C PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 693 CKNGWKGKTCH--SRDSQCD-EATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCL 749
C G+ G C +C TC +G C A C C G G C + C
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVP-TLPCE 1178
Query: 750 PNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
NPC NGGTC G C+C + G C
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 97.1 bits (240), Expect = 9e-20
Identities = 55/172 (31%), Positives = 75/172 (43%), Gaps = 31/172 (18%)
Query: 458 CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGF 517
C +D +CRDL + + C C PG+ G CE +D C S PC G + RF+C CP GF
Sbjct: 1065 CLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGF 1124
Query: 518 SGNLCQLDI--DYCEPN-PCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEV 574
G C+L + C N C +G+ C + C C E G+ C T PCE
Sbjct: 1125 GGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRC-----QVPTLPCE- 1178
Query: 575 IDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
+N C G C++ +GG C CN F+G +C
Sbjct: 1179 ---------------------ANPCLNGGTCRA-AGGVSECICNARFSGQFC 1208
Score = 92.4 bits (228), Expect = 2e-18
Identities = 51/157 (32%), Positives = 65/157 (41%), Gaps = 4/157 (2%)
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTC 768
C + C + G C D DAF C C GWEG C A C PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCE-AHVDPCHSAPCARGRCHTHPDGRFEC 1118
Query: 769 VCKEGWEGPICAQN--TNDCSPH-PCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQ 825
C G+ GP C + +CS + C + C G C C G AG C++ C+
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 826 SSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRP 862
++PC G TC C+C SG C+ G P
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLP 1215
Score = 92.4 bits (228), Expect = 2e-18
Identities = 53/177 (29%), Positives = 73/177 (41%), Gaps = 29/177 (16%)
Query: 491 CASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF-C 549
CA +PCL+ G C++ + F C C G+ G C+ +D C PC G +C+ F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118
Query: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNV-CGPHGKCKSQ 608
+CP + G C P + S NV C C+
Sbjct: 1119 RCPPGFGGPRCR-------------------------LPVPSKECSLNVTCLDGSPCEGG 1153
Query: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
S C C +G G C CE+NPC NGGTC +CIC+ + G +CE
Sbjct: 1154 SPAA-NCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 89.7 bits (221), Expect = 1e-17
Identities = 50/157 (31%), Positives = 67/157 (42%), Gaps = 10/157 (6%)
Query: 735 WEGTTCNI--ARNSS-CLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPC 791
W GT I R + C P+PC + G C ++F C C GWEGP C + + C PC
Sbjct: 1044 WPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPC 1103
Query: 792 YNSGTCVDGDNWYRCECAPGFAGPDCRINI--NECQ-SSPCAFGATCVDEINGYRCVCPP 848
D + C C PGF GP CR+ + EC + C G+ C C C
Sbjct: 1104 ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLE 1163
Query: 849 GHSGAKCQ----EVSGRPCITMGSVIPDGAKWDDDCN 881
G +G +CQ PC+ G+ G + CN
Sbjct: 1164 GLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICN 1200
Score = 87.0 bits (214), Expect = 1e-16
Identities = 46/155 (29%), Positives = 74/155 (47%), Gaps = 12/155 (7%)
Query: 265 CIPHPGCVH-GICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPD-K 319
C P P C+H G C + + C C W G C+ ++ C + PC G +T PD +
Sbjct: 1060 CAPSP-CLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHS-APCARGRC--HTHPDGR 1115
Query: 320 YQCSCPEGYSGPNCEI---AEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNID 376
++C CP G+ GP C + ++ L+ C + C+ S C C G G C
Sbjct: 1116 FECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTL 1175
Query: 377 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL 411
C N C +GGTC+ +C+C +++G+ C++
Sbjct: 1176 PCEANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 82.8 bits (203), Expect = 2e-15
Identities = 48/163 (29%), Positives = 66/163 (40%), Gaps = 12/163 (7%)
Query: 598 VCGPH-----GKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYK 652
VC P G C+ F C C G+ G C +++ C S PC G ++
Sbjct: 1059 VCAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFE 1117
Query: 653 CICSDGWEGAYCETNI--NDCSQN-PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQC 709
C C G+ G C + +CS N C +G C C C G G+ C C
Sbjct: 1118 CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177
Query: 710 DEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP 752
+ C NGGTC G +C+C + G C +A+ LP P
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKG---LPLP 1217
Score = 60.8 bits (146), Expect = 7e-09
Identities = 46/150 (30%), Positives = 60/150 (40%), Gaps = 27/150 (18%)
Query: 205 DFFGHYACDQNGNKTCMEGWMGPEC-------NRAICRQGCSPKHGSCKLPGDCRCQYGW 257
D F +AC C GW GP C + A C +G H + +CRC G+
Sbjct: 1073 DLFDAFAC------ACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF--ECRCPPGF 1124
Query: 258 QGLYCDKCIPHPGC---VHGICNEPWQ-------CLCETNWGGQLCDKDLNYCGTHQPCL 307
G C +P C V + P + C C GQ C C + PCL
Sbjct: 1125 GGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEAN-PCL 1183
Query: 308 NGGTCSNTGPDKYQCSCPEGYSGPNCEIAE 337
NGGTC G +C C +SG CE+A+
Sbjct: 1184 NGGTCRAAGGVS-ECICNARFSGQFCEVAK 1212
Score = 59.7 bits (143), Expect = 2e-08
Identities = 35/114 (30%), Positives = 53/114 (46%), Gaps = 5/114 (4%)
Query: 288 WGGQL--CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPC 345
WGG C +DL G H P +++ P + + ++ ++E C DPC
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPS--ELGGRQSWNLTAGCVSEDMCSPDPC 816
Query: 346 HNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCV 399
N G+C T F C C +TGPTC+ + C C TC+++ +GF CV
Sbjct: 817 FNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869
Score = 57.8 bits (138), Expect = 6e-08
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCA 830
++ W + + CSP PC+N GTC+ N + C C F GP C + C PC
Sbjct: 796 RQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCL 854
Query: 831 FGATCVDEINGYRCV 845
ATC + +G+ CV
Sbjct: 855 PPATCEEVPDGFVCV 869
Score = 57.0 bits (136), Expect = 1e-07
Identities = 25/68 (36%), Positives = 31/68 (45%), Gaps = 1/68 (1%)
Query: 739 TCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCV 798
T C P+PC NGGTC+V F C C + GP CAQ C PC TC
Sbjct: 802 TAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCE 860
Query: 799 DGDNWYRC 806
+ + + C
Sbjct: 861 EVPDGFVC 868
Score = 53.5 bits (127), Expect = 1e-06
Identities = 23/61 (37%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYY 435
D CSP+ C +GGTC N F C CP +TG TC C +PC+ +C+ + +
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 436 C 436
C
Sbjct: 868 C 868
Score = 53.1 bits (126), Expect = 2e-06
Identities = 24/60 (40%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM 730
CS +PC NGGTC NDF+C C + G TC ++ C C TC + D F C+
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFVCV 869
Score = 51.2 bits (121), Expect = 6e-06
Identities = 31/87 (35%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 702 CHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVV 761
C S D C C NGGTC + F C CP + G TC A+ C PC TC
Sbjct: 805 CVSED-MCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC--AQQLWCPGQPCLPPATCEE 861
Query: 762 NGESFTCVCKEGW-EGPICAQNTNDCS 787
+ F CV + + EGP A + ++ S
Sbjct: 862 VPDGFVCVAEATFREGPPAAFSGHNAS 888
Score = 51.2 bits (121), Expect = 6e-06
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 9/81 (11%)
Query: 489 DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548
D C+ +PC NGG C N F C CP F+G C + +C PC A C +
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 549 CKC--------PEDYEGKNCS 561
C P + G N S
Sbjct: 868 CVAEATFREGPPAAFSGHNAS 888
Score = 47.0 bits (110), Expect = 1e-04
Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 1/59 (1%)
Query: 633 CESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYC 691
C +PC NGGTC+ N + C C + G C + C PC TC ++ + F C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868
Score = 44.3 bits (103), Expect = 7e-04
Identities = 57/269 (21%), Positives = 88/269 (32%), Gaps = 30/269 (11%)
Query: 628 ENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVN 687
E C PC +GG+C+D ++C C+ G C I + + L+
Sbjct: 604 ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQ 663
Query: 688 D---------FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMC-PGGWEG 737
+ F + + DS + G E + PG W+
Sbjct: 664 ELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDD 723
Query: 738 TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPI--CAQNT--NDCS----PH 789
++ S P+ + G V G + W GP C Q+ + C P
Sbjct: 724 GLRHLVMLSFG-PDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPL 782
Query: 790 PCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPG 849
P NS + G D C PC G TC+ N + C CP
Sbjct: 783 PLDNSSQPSELGGRQSWNLTAGCVSEDM------CSPDPCFNGGTCLVTWNDFHCTCPAN 836
Query: 850 HSGAKCQE---VSGRPCITMGSV--IPDG 873
+G C + G+PC+ + +PDG
Sbjct: 837 FTGPTCAQQLWCPGQPCLPPATCEEVPDG 865
Score = 39.7 bits (91), Expect = 0.018
Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 9/71 (12%)
Query: 458 CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC---- 513
C N +C N + C CP + G C + + C PCL C+ + F C+
Sbjct: 816 CFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATF 874
Query: 514 ----PTGFSGN 520
P FSG+
Sbjct: 875 REGPPAAFSGH 885
Score = 38.5 bits (88), Expect = 0.039
Identities = 17/39 (43%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 664 CETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
CE C PC +GG+C DL F CDC +G TC
Sbjct: 603 CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 38.1 bits (87), Expect = 0.051
Identities = 17/45 (37%), Positives = 19/45 (42%)
Query: 736 EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICA 780
E R C P PC +GG+CV F C C GP CA
Sbjct: 597 ENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641
Score = 38.1 bits (87), Expect = 0.051
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC 409
+ C P C HGG+C DL F+C C G TC
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 35.8 bits (81), Expect = 0.26
Identities = 17/60 (28%), Positives = 28/60 (46%), Gaps = 2/60 (3%)
Query: 416 CEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCI 474
C PC N +C ++C C + G C + C GQ C A+C ++ +G+ C+
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869
Score = 35.4 bits (80), Expect = 0.33
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 333 CEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI 375
CE E C PC + GSC + F C+C+ GPTC+ I
Sbjct: 603 CERREQ-CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 32.3 bits (72), Expect = 2.8
Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 484 CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDI 526
CER ++C PC++GG C + F+C C G C +I
Sbjct: 603 CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 32.3 bits (72), Expect = 2.8
Identities = 17/65 (26%), Positives = 28/65 (43%), Gaps = 5/65 (7%)
Query: 594 ISSNVCGP----HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVN 649
+S ++C P +G + F C C FTG C + + C PC TC + +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPD 864
Query: 650 SYKCI 654
+ C+
Sbjct: 865 GFVCV 869
Score = 32.0 bits (71), Expect = 3.7
Identities = 10/35 (28%), Positives = 17/35 (48%)
Query: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCS 561
+ C P PC +G C + + + C C + G C+
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641
Score = 31.6 bits (70), Expect = 4.8
Identities = 12/33 (36%), Positives = 16/33 (48%)
Query: 415 ECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNC 447
+C PCV+ SC +L + CDC G C
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 248 bits (632), Expect = 3e-65
Identities = 98/224 (43%), Positives = 142/224 (63%), Gaps = 1/224 (0%)
Query: 338 HACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFK 397
H C +PCHN G+C++ G+ C C G+TG C T+ID+CSP C + G C+DLV F
Sbjct: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
Query: 398 CVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ 457
C CP +TG+ C+ + NEC + PC+N C + +A Y C C+ G++G +C+ +N+C
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
Query: 458 -CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTG 516
C N+A C D V G+ C CPPG+ G C +++DEC S PC NG C++ N F+CLC G
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 517 FSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
F+G+ C+L+I+ C+ NPC+N A C + + Y CKC + GK C
Sbjct: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
Score = 231 bits (590), Expect = 2e-60
Identities = 139/410 (33%), Positives = 180/410 (43%), Gaps = 41/410 (10%)
Query: 450 NINDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRF 509
NI+DC QC+ G + ++ C S P G Q +
Sbjct: 1048 NISDCKAQCKQ--------------------GTYSYSGLETCESCPL---GTYQPKFGSR 1084
Query: 510 QCL-CPTGFSG-NLCQLDIDYCEPNPCQNGAQCYNRASDYFCK-CPEDYEGKNCSHLKDH 566
CL CP S ++I C PC G ++R+ C CP DY N K
Sbjct: 1085 SCLSCPENTSTVKRGAVNISACGV-PCPEGK--FSRSGLMPCHPCPRDYYQPNAG--KAF 1139
Query: 567 CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
C P T S E + S+ S G +
Sbjct: 1140 CLACP---FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKK--RHEISSQVF 1194
Query: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 686
HE C NPC N GTC Y C+C G+ G CET+I++CS PC N G C+DLV
Sbjct: 1195 HE----CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV 1250
Query: 687 NDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNS 746
+F C+C +G+ G+ C ++C + C N G C D ++C C G+ G C N
Sbjct: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
Query: 747 SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRC 806
C NPC N C F C C G+ G C +N ++C PC N TC DG N +RC
Sbjct: 1311 -CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
Query: 807 ECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
CA GF G C +NINECQS+PC ATCVDE+N Y C C PG SG +C+
Sbjct: 1370 LCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 224 bits (570), Expect = 5e-58
Identities = 94/222 (42%), Positives = 131/222 (59%), Gaps = 2/222 (0%)
Query: 305 PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSP 364
PC N GTC G Y C CP GY+G CE C PC N G CK+ F CEC
Sbjct: 1201 PCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPS 1259
Query: 365 GWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNA 424
G+TG C NI++CS + C + G C D V G++C C + G C+ + NEC++ PC+N
Sbjct: 1260 GYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNN 1319
Query: 425 KSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDH 483
C++ + + C C PG++G C N+++CL Q C+N A+C+D N +RC+C G+ G H
Sbjct: 1320 AVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSH 1379
Query: 484 CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD 525
CE +I+EC SNPC N C +E+N + C C GFSG C+ +
Sbjct: 1380 CELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 210 bits (535), Expect = 6e-54
Identities = 123/386 (31%), Positives = 176/386 (45%), Gaps = 60/386 (15%)
Query: 301 GTHQPCLNGGTC----SNTGPDKYQC--------SCPEGYSGPNCEIAEHACLSDPCH-N 347
GT+QP +C NT K CPEG + + H C D N
Sbjct: 1075 GTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPN 1134
Query: 348 RGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG- 406
G + F G T S +I +CS + + + +V PP G
Sbjct: 1135 AGKAFCLACPFY-----GTTPFAGSRSITECSSFSSTFSAAEESVV-------PPASLGH 1182
Query: 407 --KTCQLDA---NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQN 460
K ++ + +EC PC N+ +C+ L Y C C G+ G C+ +I++C C N
Sbjct: 1183 IKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLN 1242
Query: 461 DASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520
+ C+DLV + C CP GY G CE +I+EC+S+PCLN G C + + ++C C GF G
Sbjct: 1243 NGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGL 1302
Query: 521 LCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTV 580
C+ +++ C+ NPC N A C ++ + CKCP + G C D C + PC+
Sbjct: 1303 HCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCK------- 1355
Query: 581 AMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRN 640
+G F C C GFTG++C NIN+C+SNPCRN
Sbjct: 1356 ---------------------NGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRN 1394
Query: 641 GGTCIDGVNSYKCICSDGWEGAYCET 666
TC+D +NSY C C G+ G CET
Sbjct: 1395 QATCVDELNSYSCKCQPGFSGKRCET 1420
Score = 191 bits (484), Expect = 5e-48
Identities = 84/228 (36%), Positives = 125/228 (54%), Gaps = 6/228 (2%)
Query: 264 KCIPHPGCVHGICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320
+C +P G C + + CLC + G C+ D++ C PCLN G C + ++
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP-LPCLNNGVCKDL-VGEF 1253
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380
C CP GY+G CE + C S PC N+G C + G+ C C G+ G C T +++C
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLP 440
N C + C+D V GF C CPP + G C + +EC ++PC N +CK+ S+ C C
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
Query: 441 GWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERD 487
G+ G +C++NIN+C C+N A+C D +N Y C C PG++G CE +
Sbjct: 1374 GFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 179 bits (455), Expect = 1e-44
Identities = 81/216 (37%), Positives = 125/216 (57%), Gaps = 12/216 (5%)
Query: 243 GSCKLPGD---CRCQYGWQGLYC----DKCIPHPGCVHGICNE---PWQCLCETNWGGQL 292
G+C+ G C C G+ GL C D+C P P +G+C + + C C + + GQ
Sbjct: 1206 GTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQR 1265
Query: 293 CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK 352
C++++N C + PCLN G C + G Y+C+C +G+ G +CE + C S+PC N C+
Sbjct: 1266 CEENINECSS-SPCLNKGICVD-GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCE 1323
Query: 353 ETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLD 412
+ GF C+C PG+ G C N+D+C C +G TC+D N F+C+C +TG C+L+
Sbjct: 1324 DQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELN 1383
Query: 413 ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448
NEC++ PC N +C + + SY C C PG+ G+ C+
Sbjct: 1384 INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 88.6 bits (218), Expect = 3e-17
Identities = 89/356 (25%), Positives = 132/356 (37%), Gaps = 45/356 (12%)
Query: 611 GKFTCD-CNKGFTGTYCHE-NINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668
G+ C C G Y H NI+DC++ C+ G G+ + + ++ + +
Sbjct: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCESCPLGTYQPKFGSRSC 1086
Query: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFK 728
C +N R VN C +GK S C C + G AF
Sbjct: 1087 LSCPEN---TSTVKRGAVNISACGVPCP-EGKFSRSGLMPCHP--CPRDYYQPNAGKAFC 1140
Query: 729 CMCPGGWEGTTCNIARNS----SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN 784
CP + GTT S S + VV S + K I +Q +
Sbjct: 1141 LACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRH---EISSQVFH 1195
Query: 785 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844
+C +PC+NSGTC Y C C G+ G C +I+EC PC C D + + C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 845 VCPPGHSGAKCQ----EVSGRPCITMGSVIPD-------------GAKWDDDCNTCQ--- 884
CP G++G +C+ E S PC+ G + G + + N CQ
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
Query: 885 CLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940
CLN + +V G C G G++ D+C PC C+ +
Sbjct: 1316 CLNNAVCEDQV--GGFLCKCPPGFLGTRCGKNV-----DECLSQPCKNGATCKDGA 1364
Score = 79.7 bits (195), Expect = 2e-14
Identities = 54/166 (32%), Positives = 70/166 (42%), Gaps = 34/166 (20%)
Query: 209 HYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCR--CQYGWQGLYCDKCI 266
HY +C G+M R++C + +G+ P CR C++ Q
Sbjct: 3431 HYQYGDMITYSCYSGYMLEGFLRSVCLE-----NGTWTSPPICRAVCRFPCQN------- 3478
Query: 267 PHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPE 326
GIC P C C W G+LC++ + PCLNGG C P YQC CP
Sbjct: 3479 ------GGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRC--VAP--YQCDCPP 3524
Query: 327 GYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCS 372
G++G C A C S PC N G C + C C WTG CS
Sbjct: 3525 GWTGSRCHTA--VCQS-PCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
Score = 77.0 bits (188), Expect = 1e-13
Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 25/157 (15%)
Query: 178 HFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQG 237
H++Y +T Y G+ F R C +NG W P RA+CR
Sbjct: 3431 HYQYGDMITYS-CYSGYMLEGFLRS--------VCLENGT------WTSPPICRAVCRFP 3475
Query: 238 CSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVH-GICNEPWQCLCETNWGGQLCDKD 296
C G C+ P C C GW G C++ I C++ G C P+QC C W G C
Sbjct: 3476 CQ-NGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTA 3534
Query: 297 LNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNC 333
+ PCLNGG C +C C ++G NC
Sbjct: 3535 V----CQSPCLNGGKCVRPN----RCHCLSSWTGHNC 3563
Score = 77.0 bits (188), Expect = 1e-13
Identities = 42/105 (40%), Positives = 51/105 (48%), Gaps = 16/105 (15%)
Query: 305 PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSP 364
PC NGG C CSCPEG+ G CE E C+ PC N G C ++C+C P
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRCVAP---YQCDCPP 3524
Query: 365 GWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC 409
GWTG C T + + C +GG C V +C C WTG C
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 76.3 bits (186), Expect = 2e-13
Identities = 60/188 (31%), Positives = 71/188 (37%), Gaps = 42/188 (22%)
Query: 572 CEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCN-----KGFTGTYC 626
CE I A N GV Y Q G T C +GF + C
Sbjct: 3411 CEKISCGPPAHVENAIARGVHY--------------QYGDMITYSCYSGYMLEGFLRSVC 3456
Query: 627 HENIN-----DCESN---PCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHN 678
EN C + PC+NGG C C C +GW G CE I C PC N
Sbjct: 3457 LENGTWTSPPICRAVCRFPCQNGGIC---QRPNACSCPEGWMGRLCEEPI--CIL-PCLN 3510
Query: 679 GGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGT 738
GG C V + CDC GW G CH+ Q + C NGG C +C C W G
Sbjct: 3511 GGRC---VAPYQCDCPPGWTGSRCHTAVCQ---SPCLNGGKCVRPN---RCHCLSSWTGH 3561
Query: 739 TCNIARNS 746
C+ R +
Sbjct: 3562 NCSRKRRT 3569
Score = 67.8 bits (164), Expect = 6e-11
Identities = 41/110 (37%), Positives = 53/110 (48%), Gaps = 19/110 (17%)
Query: 454 CLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC 513
C CQN C+ C CP G+ G CE I PCLNGG C + +QC C
Sbjct: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDC 3522
Query: 514 PTGFSGNLCQLDIDYCEPNPCQNGAQCY--NRASDYFCKCPEDYEGKNCS 561
P G++G+ C + C+ +PC NG +C NR C C + G NCS
Sbjct: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVRPNR-----CHCLSSWTGHNCS 3564
Score = 67.4 bits (163), Expect = 8e-11
Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 14/104 (13%)
Query: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGW 442
C +GG CQ C CP W G+ C+ PC+N C +A Y CDC PGW
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPGW 3526
Query: 443 MGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCER 486
G C + C C N C V RC C + G +C R
Sbjct: 3527 TGSRCHTAV--CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565
Score = 66.6 bits (161), Expect = 1e-10
Identities = 68/263 (25%), Positives = 91/263 (34%), Gaps = 72/263 (27%)
Query: 640 NGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV----NDFYCD--- 692
N G ++G + C + W + C NPC + +FY D
Sbjct: 3326 NRGYSLEGPSEAHCTENGTWSHP-----VPLCKPNPCPVPFVIPENALLSEKEFYVDQNV 3380
Query: 693 ---CKNGW-----------KGKTCHSRDSQCDEATCNNG---------GTCYDEGDAFKC 729
C+ G+ +T ++C++ +C G Y GD
Sbjct: 3381 SIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITY 3440
Query: 730 MCPGGW--EGTTCNIARNSSCLPN---------------PCHNGGTCVVNGESFTCVCKE 772
C G+ EG S CL N PC NGG C C C E
Sbjct: 3441 SCYSGYMLEGFL-----RSVCLENGTWTSPPICRAVCRFPCQNGGICQ---RPNACSCPE 3492
Query: 773 GWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFG 832
GW G +C + PC N G CV Y+C+C PG+ G C + CQ SPC G
Sbjct: 3493 GWMGRLCEE---PICILPCLNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNG 3543
Query: 833 ATCVDEINGYRCVCPPGHSGAKC 855
CV RC C +G C
Sbjct: 3544 GKCV---RPNRCHCLSSWTGHNC 3563
Score = 60.1 bits (144), Expect = 1e-08
Identities = 29/85 (34%), Positives = 38/85 (44%), Gaps = 2/85 (2%)
Query: 212 CDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGC 271
C + +C EGWMG C IC C G C P C C GW G C + C
Sbjct: 3482 CQRPNACSCPEGWMGRLCEEPICILPCL-NGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC 3540
Query: 272 VHG-ICNEPWQCLCETNWGGQLCDK 295
++G C P +C C ++W G C +
Sbjct: 3541 LNGGKCVRPNRCHCLSSWTGHNCSR 3565
Score = 52.0 bits (123), Expect = 3e-06
Identities = 39/125 (31%), Positives = 51/125 (40%), Gaps = 26/125 (20%)
Query: 772 EGWEGPICAQNTNDCSP--------HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININE 823
EG+ +C +N SP PC N G C + C C G+ G C I
Sbjct: 3449 EGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPN---ACSCPEGWMGRLCEEPI-- 3503
Query: 824 CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ-EVSGRPCITMGSVIPDGAKWDDDCNT 882
C PC G CV Y+C CPPG +G++C V PC+ G + N
Sbjct: 3504 C-ILPCLNGGRCVAP---YQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRP--------NR 3551
Query: 883 CQCLN 887
C CL+
Sbjct: 3552 CHCLS 3556
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 210 YACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDK 264
Y CD C GW G C+ A+C+ C G C P C C W G C +
Sbjct: 3518 YQCD------CPPGWTGSRCHTAVCQSPCL-NGGKCVRPNRCHCLSSWTGHNCSR 3565
Score = 40.4 bits (93), Expect = 0.010
Identities = 64/268 (23%), Positives = 92/268 (34%), Gaps = 61/268 (22%)
Query: 599 CGPHGKCKSQSG-GKFTCDCNKGF-------------TGTYCHE----NINDCESNPCRN 640
C G CK + G F C C KG+ +GTY E I+ C P N
Sbjct: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
Query: 641 GGTCIDGVNSYKCICSDGW--EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWK 698
+ + C+C +G+ G CE ++ + P NG ++ N+ + N
Sbjct: 348 HTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKPPENGYFIQNTCNNHF----NAAC 402
Query: 699 GKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTT--CNIARNSSCLPNPCHNG 756
G CH G C+ G W G+ C + R L P H
Sbjct: 403 GVRCHP-------------GFDLVGSSIILCLPNGLWSGSESYCRV-RTCPHLRQPKHGH 448
Query: 757 GTCVVNGESF--TCV--CKEGW--EGP---ICAQNTNDCSPHPCYNSGTCVDGDNWYRCE 807
+C + TC+ C EG+ EG C N+ P P CV+
Sbjct: 449 ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP-----RCVER------H 497
Query: 808 CAPGFAGPDCRININECQSSPCAFGATC 835
C+ D I+ + C P FG C
Sbjct: 498 CSTFQMPKDVIISPHNCGKQPAKFGTIC 525
Score = 40.4 bits (93), Expect = 0.010
Identities = 36/135 (26%), Positives = 46/135 (34%), Gaps = 36/135 (26%)
Query: 524 LDIDYCEP-NPCQNGAQCYNRASDYFCKCPEDY--EGKNCS--------------HLKDH 566
LD+D C + C A C N Y C C Y +GKNC+ H
Sbjct: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGE 1803
Query: 567 CRTTPCEVIDSC-----------TVAMASNDTPEGVRYISSNVCG----PHGKCKSQ--- 608
T EV SC + S + + Y + CG P C +
Sbjct: 1804 IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAF 1863
Query: 609 -SGGKFTCDCNKGFT 622
G K T CNKG+T
Sbjct: 1864 TFGSKVTYRCNKGYT 1878
Score = 38.5 bits (88), Expect = 0.039
Identities = 54/202 (26%), Positives = 79/202 (39%), Gaps = 25/202 (12%)
Query: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC 351
LCD+ + C C G ++TG ++C C +GY G + AC S GS
Sbjct: 280 LCDEGKDCCDRMGSCKCG---THTG--HFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
Query: 352 KETSLGFECECSPGWTGPTCSTNIDD--CSPNNCSHGGTCQDLVNGFKCVCPPQ---WTG 406
S C T P ST+ +D C + G TC +LV+ + PP+ +
Sbjct: 335 GGISSCIPCP-DENHTSPPGSTSPEDCVCREGYRASGQTC-ELVH-CPALKPPENGYFIQ 391
Query: 407 KTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPG--WMGQNCDININDC--LGQCQN-- 460
TC N A V +L+ S CLP W G + C L Q ++
Sbjct: 392 NTCN---NHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGH 448
Query: 461 -DASCRDLVNGYRCI--CPPGY 479
S R+++ C+ C GY
Sbjct: 449 ISCSTREMLYKTTCLVACDEGY 470
Score = 35.8 bits (81), Expect = 0.26
Identities = 35/146 (23%), Positives = 59/146 (40%), Gaps = 23/146 (15%)
Query: 293 CDKDLNYCGTH-QPCLNGGTCSNTGP--DKYQCSCP----EGYSGPNCEIAEHACLSDPC 345
CD G Q CLN G + P ++ C P G+ + + + ++ C
Sbjct: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSAD-DFYAGSTVTYQC 1716
Query: 346 HNRGSCKETSLGFECECSPGWTG--PTCSTNIDDCSP-NNCSHGGTCQDLVNGFKCVCPP 402
+N S F C + W G P+C ++D+C+ ++CS +C ++ + C C P
Sbjct: 1717 NNGYYLLGDSRMF-CTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
Query: 403 QWTGKTCQLDANECEAKPCVNAKSCK 428
+TG + K C CK
Sbjct: 1775 PYTG----------DGKNCAEPIKCK 1790
Score = 35.4 bits (80), Expect = 0.33
Identities = 35/149 (23%), Positives = 52/149 (34%), Gaps = 28/149 (18%)
Query: 260 LYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGG--------- 310
L+CD PG + N CL + W L + CG P NG
Sbjct: 1656 LFCD-----PG-FQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAG 1709
Query: 311 -----TCSN----TGPDKYQCSCPEGYSG--PNCEIAEHACLSDPCHNRGSCKETSLGFE 359
C+N G + C+ ++G P+C + + C SC +
Sbjct: 1710 STVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI 1769
Query: 360 CECSPGWT--GPTCSTNIDDCSPNNCSHG 386
C C P +T G C+ I +P N +G
Sbjct: 1770 CSCVPPYTGDGKNCAEPIKCKAPGNPENG 1798
Score = 34.7 bits (78), Expect = 0.57
Identities = 33/135 (24%), Positives = 50/135 (37%), Gaps = 33/135 (24%)
Query: 433 SYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
SY CD G++C D +G C+ C + CIC GY G + + C
Sbjct: 278 SYLCD-----EGKDCC----DRMGSCK----CGTHTGHFECICEKGYYGKGLQYECTACP 324
Query: 493 SN---------------PCLNGGHCQ--NEINRFQCLCPTGF--SGNLCQLDIDYCEPNP 533
S PC + H + C+C G+ SG C+L + P
Sbjct: 325 SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKP 383
Query: 534 CQNGAQCYNRASDYF 548
+NG N +++F
Sbjct: 384 PENGYFIQNTCNNHF 398
Score = 34.3 bits (77), Expect = 0.74
Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 27/129 (20%)
Query: 729 CMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTND 785
C+ G W + R S +P P NG + G + T C G+ + +
Sbjct: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYY--LLGDSRMF 1729
Query: 786 CSPHPCYN--SGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYR 843
C+ + +N S +C+D D ECA G S C+ A+C++ Y
Sbjct: 1730 CTDNGSWNGVSPSCLDVD-----ECAVG---------------SDCSEHASCLNVDGSYI 1769
Query: 844 CVCPPGHSG 852
C C P ++G
Sbjct: 1770 CSCVPPYTG 1778
Score = 34.3 bits (77), Expect = 0.74
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 4/54 (7%)
Query: 398 CVCPPQWTGKTCQ-LDANECEA-KPCVNAKSCKNLIASYYCDCLPGWM--GQNC 447
C W G + LD +EC C SC N+ SY C C+P + G+NC
Sbjct: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNC 1783
Score = 30.8 bits (68), Expect = 8.2
Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 57/185 (30%)
Query: 233 ICRQG--CSPKHGSCKLPG-----DCRCQYGWQG-------LYC--------------DK 264
+C +G C + GSCK +C C+ G+ G C
Sbjct: 280 LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISS 339
Query: 265 CIPHPGCVHGI---CNEPWQCLCETNW--GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDK 319
CIP P H P C+C + GQ C +L +C +P NG NT +
Sbjct: 340 CIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC--ELVHCPALKPPENGYFIQNTCNNH 397
Query: 320 YQCSC-------------------PEG-YSGPN--CEIAEHACLSDPCHNRGSCKETSLG 357
+ +C P G +SG C + L P H SC +
Sbjct: 398 FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREML 457
Query: 358 FECEC 362
++ C
Sbjct: 458 YKTTC 462
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 241 bits (614), Expect = 4e-63
Identities = 123/349 (35%), Positives = 165/349 (47%), Gaps = 46/349 (13%)
Query: 438 CLPGWMGQNCDININDCLGQCQNDASCRDLVNG--YRCICPPGYAGDHCERDIDECASNP 495
C+PG + + ND +C C + + C C Y G CE + D C P
Sbjct: 307 CVPG------ESHANDL--ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKP 357
Query: 496 CLNGGHC-----QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCK 550
C N C + + + F C+C G++G LCQ IDYC +PC+NGA C + S + C+
Sbjct: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417
Query: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
CPE Y G C D C ++PC+ +C V G
Sbjct: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYV----------------------------DG 449
Query: 611 GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIND 670
FTC+C+ GFTG C + I+ C +PC +G TC SYKC+C G+ G YCE N+
Sbjct: 450 VHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNE 508
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM 730
C PC N TCRDLVN + C C +KG C C +C NG TC +G C+
Sbjct: 509 CLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCI 568
Query: 731 CPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
C G+ G C+I N C NPCH+GG+C+ + C C GW G C
Sbjct: 569 CAPGFTGEECDIDIN-ECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616
Score = 233 bits (594), Expect = 8e-61
Identities = 114/310 (36%), Positives = 171/310 (55%), Gaps = 25/310 (8%)
Query: 238 CSPKHGSCKLPGD----CRCQYGWQGLYCDK--------CIPHPGCVHGICNEP-----W 280
CS K P + C C+ + G +C++ C + C+ NE +
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA--NEKQDGSNF 376
Query: 281 QCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC 340
C+C + G+LC ++YC PC NG TC ++ + C CPEGY G CE C
Sbjct: 377 TCVCLPGYTGELCQSKIDYC-ILDPCRNGATCISS-LSGFTCQCPEGYFGSACEEKVDPC 434
Query: 341 LSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVC 400
S PC N G+C + F C CSPG+TGPTC+ ID C+ + C+HG TC+ + +KC+C
Sbjct: 435 ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLC 493
Query: 401 PPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQ 459
P + G C+ + NEC + PC+NA +C++L+ Y C CL + G +C++ + C C
Sbjct: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCL 553
Query: 460 NDASC-RDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFS 518
N A+C D +NG CIC PG+ G+ C+ DI+EC SNPC +GG C ++ N + C CP G+
Sbjct: 554 NGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
Query: 519 GNLCQLDIDY 528
G C++ + +
Sbjct: 613 GANCEIHLQW 622
Score = 231 bits (589), Expect = 3e-60
Identities = 122/328 (37%), Positives = 164/328 (50%), Gaps = 34/328 (10%)
Query: 534 CQNGAQCYNRASD--YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGV 591
C +C + S+ + C C E Y G C D C+ PC+ SC
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY-DACQRKPCQNNASC------------- 364
Query: 592 RYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSY 651
I +N + Q G FTC C G+TG C I+ C +PCRNG TCI ++ +
Sbjct: 365 --IDAN--------EKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF 414
Query: 652 KCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDE 711
C C +G+ G+ CE ++ C+ +PC N GTC F C+C G+ G TC C
Sbjct: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL 474
Query: 712 ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTC--VVNGESFTCV 769
+ C +G TC G ++KC+C G+ G C N CL PC N TC +VNG + CV
Sbjct: 475 SPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNE-CLSAPCLNAATCRDLVNG--YECV 530
Query: 770 CKEGWEGPICAQNTNDCSPHPCYNSGTC-VDGDNWYRCECAPGFAGPDCRININECQSSP 828
C ++G C + C+ C N TC DG N C CAPGF G +C I+INEC S+P
Sbjct: 531 CLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNP 589
Query: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQ 856
C G +C+D+ NGY C CP G GA C+
Sbjct: 590 CHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 208 bits (530), Expect = 2e-53
Identities = 111/317 (35%), Positives = 153/317 (48%), Gaps = 20/317 (6%)
Query: 370 TCSTNIDDCSPNNCSHGGTCQDLVNG--FKCVCPPQWTGKTCQLDANECEAKPCVNAKSC 427
TC + CS G C + F C C Q+ G C+ + + C+ KPC N SC
Sbjct: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
Query: 428 -----KNLIASYYCDCLPGWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAG 481
K +++ C CLPG+ G+ C I+ C L C+N A+C ++G+ C CP GY G
Sbjct: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG 424
Query: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCY 541
CE +D CAS+PC N G C + F C C GF+G C ID+C +PC +G C
Sbjct: 425 SACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT-CR 483
Query: 542 NRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCT----------VAMASNDTPEGV 591
+ + Y C C Y G C + C + PC +C +A E
Sbjct: 484 SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELY 543
Query: 592 RYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSY 651
+ +NV +G G TC C GFTG C +IN+C+SNPC +GG+C+D N Y
Sbjct: 544 KDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGY 603
Query: 652 KCICSDGWEGAYCETNI 668
C C GW GA CE ++
Sbjct: 604 NCHCPHGWVGANCEIHL 620
Score = 199 bits (505), Expect = 2e-50
Identities = 106/329 (32%), Positives = 151/329 (45%), Gaps = 39/329 (11%)
Query: 306 CLNGGTCSNTGPDK--YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC-----KETSLGF 358
C G C+ T P + + C+C E Y G CE + AC PC N SC K+ F
Sbjct: 319 CSGKGKCT-TKPSEATFSCTCEEQYVGTFCEEYD-ACQRKPCQNNASCIDANEKQDGSNF 376
Query: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
C C PG+TG C + ID C + C +G TC ++GF C CP + G C+ + C +
Sbjct: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS 436
Query: 419 KPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPP 477
PC N +C + C+C PG+ G C I+ C L C + +CR + Y+C+C P
Sbjct: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDP 495
Query: 478 GYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNG 537
GY G +CE + +EC S PCLN C++ +N ++C+C + G C+L D C C NG
Sbjct: 496 GYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNG 555
Query: 538 AQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSN 597
A C + + C C + G+ C + C + PC SC D P G
Sbjct: 556 ATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCL------DQPNG------- 602
Query: 598 VCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
+ C C G+ G C
Sbjct: 603 ---------------YNCHCPHGWVGANC 616
Score = 154 bits (388), Expect = 6e-37
Identities = 95/300 (31%), Positives = 136/300 (45%), Gaps = 42/300 (14%)
Query: 665 ETNINDCSQNPCHNGGTCRDLVND--FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYD 722
E++ ND C G C ++ F C C+ + G C D+ C C N +C D
Sbjct: 311 ESHANDLE---CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA-CQRKPCQNNASCID 366
Query: 723 -----EGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGP 777
+G F C+C G+ G C ++ C+ +PC NG TC+ + FTC C EG+ G
Sbjct: 367 ANEKQDGSNFTCVCLPGYTGELCQ-SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGS 425
Query: 778 ICAQNTNDCSPHPCYNSGTC-VDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCV 836
C + + C+ PC N+GTC VDG + + C C+PGF GP C I+ C SPCA G TC
Sbjct: 426 ACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCR 483
Query: 837 DEINGYRCVCPPGHSGAKCQE-------------------VSGRPCITMGSVIPDGAK-W 876
Y+C+C PG+ G C+E V+G C+ + + +
Sbjct: 484 SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELY 543
Query: 877 DDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGEC 936
D C CLNG S G C+ G +G+ C I ++C +PC G C
Sbjct: 544 KDPCANVSCLNGATCDSDGLNG--TCICAPGF----TGEEC-DIDINECDSNPCHHGGSC 596
Score = 152 bits (385), Expect = 1e-36
Identities = 92/291 (31%), Positives = 136/291 (46%), Gaps = 32/291 (10%)
Query: 186 TCDDYYYGFGCNKF--CRPRDDFFGHYACDQNGNK-------TCMEGWMGPECNRAI--- 233
TC++ Y G C ++ C+ + D N + C+ G+ G C I
Sbjct: 337 TCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYC 396
Query: 234 ----CRQGCSPKHGSCKLPG-DCRCQYGWQGLYC----DKCIPHPGCVHGIC---NEPWQ 281
CR G + L G C+C G+ G C D C P +G C +
Sbjct: 397 ILDPCRNGATC---ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFT 453
Query: 282 CLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL 341
C C + G C + +++C PC +G TC + G Y+C C GY G CE + CL
Sbjct: 454 CNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGTS-YKCLCDPGYHGLYCEEEYNECL 510
Query: 342 SDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ-DLVNGFKCVC 400
S PC N +C++ G+EC C + G C D C+ +C +G TC D +NG C+C
Sbjct: 511 SAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCIC 569
Query: 401 PPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDINI 451
P +TG+ C +D NEC++ PC + SC + Y C C GW+G NC+I++
Sbjct: 570 APGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
Score = 112 bits (279), Expect = 3e-24
Identities = 78/281 (27%), Positives = 118/281 (41%), Gaps = 52/281 (18%)
Query: 742 IARNSSCLPNPCH-NGGTCVVNGE--------SFTCVCKEGWEGPICAQNTNDCSPHPCY 792
+ + S+C+P H N C G+ +F+C C+E + G C + + C PC
Sbjct: 301 VVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRKPCQ 359
Query: 793 NSGTCVD------GDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVC 846
N+ +C+D G N + C C PG+ G C+ I+ C PC GATC+ ++G+ C C
Sbjct: 360 NNASCIDANEKQDGSN-FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQC 418
Query: 847 PPGHSGAKCQE----VSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIA--CSKV--WCG 898
P G+ G+ C+E + PC G+ DG + TC C G C+++ +C
Sbjct: 419 PEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF-----TCNCSPGFTGPTCAQLIDFCA 473
Query: 899 PRPCLLHKGHSECPSGQSCIPILDD-------------QCFVHPCTGVGECRS-----SS 940
PC H C S + L D +C PC CR
Sbjct: 474 LSPC----AHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529
Query: 941 LQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICS 981
+ + K T Y+D CAN++ S GL IC+
Sbjct: 530 VCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICA 570
Score = 70.1 bits (170), Expect = 1e-11
Identities = 32/83 (38%), Positives = 44/83 (53%), Gaps = 16/83 (19%)
Query: 304 QPCLNGGTCSN-----------TGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK 352
QPC NGG C++ G Y C+CP G SG NC++ C S+PCH+ G+C
Sbjct: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-GNCS 109
Query: 353 ETSL----GFECECSPGWTGPTC 371
+S G+ C C+ G+ GP C
Sbjct: 110 SSSSSSSDGYLCICNEGYEGPNC 132
Score = 64.7 bits (156), Expect = 5e-10
Identities = 34/86 (39%), Positives = 40/86 (46%), Gaps = 17/86 (19%)
Query: 491 CASNPCLNGGHCQNEINR------------FQCLCPTGFSGNLCQLDIDYCEPNPCQNGA 538
CA+ PC NGG C + + C CP G SG CQL D C NPC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG- 106
Query: 539 QCYNRASD----YFCKCPEDYEGKNC 560
C + +S Y C C E YEG NC
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 59.7 bits (143), Expect = 2e-08
Identities = 29/93 (31%), Positives = 38/93 (40%), Gaps = 16/93 (17%)
Query: 704 SRDSQCDEATCNNGGTCYDEGD------------AFKCMCPGGWEGTTCNIARNSSCLPN 751
S C C NGG C + + C CP G G C + + C N
Sbjct: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP-CASN 101
Query: 752 PCHNGGTCVVNGES---FTCVCKEGWEGPICAQ 781
PCH+G + S + C+C EG+EGP C Q
Sbjct: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 58.9 bits (141), Expect = 3e-08
Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 15/85 (17%)
Query: 633 CESNPCRNGGTCID------------GVNSYKCICSDGWEGAYCETNINDCSQNPCHNG- 679
C + PCRNGG C G Y C C G GA C+ + C+ NPCH+G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 680 --GTCRDLVNDFYCDCKNGWKGKTC 702
+ + + C C G++G C
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 57.8 bits (138), Expect = 6e-08
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 15/87 (17%)
Query: 786 CSPHPCYNSGTCVD------------GDNWYRCECAPGFAGPDCRININECQSSPCAFG- 832
C+ PC N G C G+ Y C C G +G +C++ + C S+PC G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 833 --ATCVDEINGYRCVCPPGHSGAKCQE 857
++ +GY C+C G+ G C++
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 51.2 bits (121), Expect = 6e-06
Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 5/58 (8%)
Query: 470 GYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR----FQCLCPTGFSGNLCQ 523
GY C CP G +G +C+ D CASNPC + G+C + + + C+C G+ G C+
Sbjct: 77 GYSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 50.8 bits (120), Expect = 8e-06
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 15/85 (17%)
Query: 748 CLPNPCHNGGTCVVNGE------------SFTCVCKEGWEGPICAQNTNDCSPHPCYN-- 793
C PC NGG C E ++C C G G C + C+ +PC++
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 794 -SGTCVDGDNWYRCECAPGFAGPDC 817
S + + Y C C G+ GP+C
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/115 (25%), Positives = 37/115 (32%), Gaps = 43/115 (37%)
Query: 529 CEPNPCQNGAQCYNRASD------------YFCKCPEDYEGKNCSHLKDHCRTTPCEVID 576
C PC+NG C +R Y C CP G NC + D C + PC
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
Query: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK---FTCDCNKGFTGTYCHE 628
HG C S S + C CN+G+ G C +
Sbjct: 105 -------------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 49.7 bits (117), Expect = 2e-05
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 613 FTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS---YKCICSDGWEGAYCE 665
++C C G +G C + C SNPC +G +S Y CIC++G+EG CE
Sbjct: 78 YSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 49.3 bits (116), Expect = 2e-05
Identities = 25/86 (29%), Positives = 36/86 (41%), Gaps = 15/86 (17%)
Query: 378 CSPNNCSHGGTCQDLVN------------GFKCVCPPQWTGKTCQLDANECEAKPCVNAK 425
C+ C +GG C G+ C CP +G CQL A+ C + PC +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 426 SCKNLIAS---YYCDCLPGWMGQNCD 448
+ +S Y C C G+ G NC+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/93 (35%), Positives = 41/93 (44%), Gaps = 6/93 (6%)
Query: 248 PGDCRCQYGWQGLYCDKCIPHPGCVHGI-CNEP-WQCLCETNWGGQLCDKDLNYCGTHQP 305
PG C Q G C P P H EP + C C G C + C ++ P
Sbjct: 45 PGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN-P 102
Query: 306 CLNGG--TCSNTGPDKYQCSCPEGYSGPNCEIA 336
C +G + S++ D Y C C EGY GPNCE A
Sbjct: 103 CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Score = 48.5 bits (114), Expect = 4e-05
Identities = 23/86 (26%), Positives = 33/86 (38%), Gaps = 15/86 (17%)
Query: 340 CLSDPCHNRGSCKET------------SLGFECECSPGWTGPTCSTNIDDCSPNNCSHG- 386
C + PC N G C G+ C C G +G C D C+ N C HG
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 387 --GTCQDLVNGFKCVCPPQWTGKTCQ 410
+ +G+ C+C + G C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 20/89 (22%)
Query: 416 CEAKPCVNAKSCKNLIA------------SYYCDCLPGWMGQNCDININDCL------GQ 457
C A+PC N C + Y C C G G NC + + C G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 458 CQNDASCRDLVNGYRCICPPGYAGDHCER 486
C + +S +GY CIC GY G +CE+
Sbjct: 108 CSSSSSSSS--DGYLCICNEGYEGPNCEQ 134
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/88 (26%), Positives = 31/88 (35%), Gaps = 15/88 (17%)
Query: 671 CSQNPCHNGGTCRDLVND------------FYCDCKNGWKGKTCHSRDSQCDEATCNNGG 718
C+ PC NGG C + C C G G C C C++G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 719 ---TCYDEGDAFKCMCPGGWEGTTCNIA 743
+ D + C+C G+EG C A
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Score = 40.4 bits (93), Expect = 0.010
Identities = 39/152 (25%), Positives = 57/152 (37%), Gaps = 38/152 (25%)
Query: 824 CQSSPCAFGATCVDEIN------------GYRCVCPPGHSGAKCQEVSGRPCITMGSVIP 871
C + PC G C GY C CP G SGA CQ V+ PC +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCAS------ 100
Query: 872 DGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCT 931
+ C+ C + + S + C+ ++G+ E P+ + +P L P T
Sbjct: 101 ------NPCHHGNCSSSSSSSSDGYL----CICNEGY-EGPNCEQALPSL-------PAT 142
Query: 932 GVGECRS-SSLQPVKTKCTSDSYYQDNCANIT 962
G E + LQPV D + A +T
Sbjct: 143 GWTESMAPRQLQPVPATQEPDKILPRSQATVT 174
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 234 bits (596), Expect = 5e-61
Identities = 231/805 (28%), Positives = 293/805 (36%), Gaps = 183/805 (22%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYA-CD-QNGNKTCMEGWMGPECNRAI--------CRQ 236
C + +G GC + C H A CD + G C+ G++G C C+
Sbjct: 773 CPEGRWGLGCQEICPACQ----HAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQT 828
Query: 237 GCS-PKHGSCK-LPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCD 294
CS G C G C C GW G C + C+T G C
Sbjct: 829 RCSCANDGHCHPATGHCSCAPGWTGFSCQRA------------------CDTGHWGPDCS 870
Query: 295 KDLNYCGTHQPC--LNGGTCSNTGPDKYQCS--CPEGYSGPNCEIAEHACLSDPCHNRGS 350
N H C ++G G +C CP+G+ GP CE C C + +
Sbjct: 871 HPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCE---QRC---QCQHGAA 924
Query: 351 CKETSLGFECECSPGWTGPTCST-------NIDDCSPNNCSHGGTCQDLVNGFKCVCPPQ 403
C S C C GW G C +D S NC+ G C D VNG C+CP
Sbjct: 925 CDHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC-DAVNG-SCLCPAG 980
Query: 404 WTGKTCQLDA-------NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNC--------- 447
G C N +A C N SC + C C PGWMG +C
Sbjct: 981 RRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQ--CHCAPGWMGPSCLQACPAGLY 1038
Query: 448 -DININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA----------SNPC 496
D + CL CQN +C D V+G+ C CP G+AG CE+ EC S C
Sbjct: 1039 GDNCRHSCL--CQNGGTC-DPVSGH-CACPEGWAGLACEK---ECLPRDVRAGCRHSGGC 1091
Query: 497 LNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYE 556
LNGG C R CLCP G++G+ CQ +PC G + A C CP
Sbjct: 1092 LNGGLCDPHTGR--CLCPAGWTGDKCQ--------SPCLRG--WFGEACAQRCSCPP--- 1136
Query: 557 GKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVC-GPHGKCKSQSGGKFTC 615
G C H+ CR P C A E + C G + C +G TC
Sbjct: 1137 GAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQ--CPGENPACHPATG---TC 1191
Query: 616 DCNKGFTGTYCHENINDCESNP-------CRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668
C G+ G C + P C NGG+C + C C G+ G C
Sbjct: 1192 SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA--CRCPTGFLGTDCNLTC 1249
Query: 669 NDCSQNP-------CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ------CDEA-TC 714
P C G C + C C G G C Q C+ +C
Sbjct: 1250 PQGRFGPNCTHVCGCGQGAACDPVTGT--CLCPPGRAGVRCERGCPQNRFGVGCEHTCSC 1307
Query: 715 NNGGTCYDEGDAFKCMCPGGWEGTTCNIA-----RNSSC-LPNPCHNGGTCVVNGESFTC 768
NGG C+ + C C GW G C +A ++C L CHN TC + TC
Sbjct: 1308 RNGGLCHASNGS--CSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTC--EPATGTC 1363
Query: 769 VCKEGWEGPICAQNTNDCSPH----------------PCYN-SGTCV--DGDNWYRCE-- 807
C G+ G C + C P PC SG C+ G + + CE
Sbjct: 1364 RCGPGFYGQACE---HPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERG 1420
Query: 808 CAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGR----PC 863
C PG G C Q C GA C D + G C+CPPG SGA C R P
Sbjct: 1421 CEPGSFGEGCH------QRCDCDGGAPC-DPVTGL-CLCPPGRSGATCNLDCRRGQFGPS 1472
Query: 864 ITMGSVIPDGAKWDDDCNTCQCLNG 888
T+ GA D C C++G
Sbjct: 1473 CTLHCDCGGGADCDPVSGQCHCVDG 1497
Score = 211 bits (538), Expect = 3e-54
Identities = 218/805 (27%), Positives = 304/805 (37%), Gaps = 178/805 (22%)
Query: 185 VTCDDYYYGFGCNKFCRPRDDFFGHYACD-QNGNKTCMEGWMGPECNRAI--------CR 235
+TC + +G GC++ C+ +CD ++G+ +C G+ G C C
Sbjct: 639 LTCPPWAFGPGCSEECQCVQPH--TQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCW 696
Query: 236 QGCS-PKHGSC-KLPGDC--RCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQ 291
Q C+ P +C + G+C RC G+QG C + P G C+ C GG
Sbjct: 697 QACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECP-VGTFGVNCSSSCSC------GGA 749
Query: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE----IAEHACLSDPCHN 347
C C C G TG D + CPEG G C+ +HA DP
Sbjct: 750 PCHGVTGQC----RCPPG----RTGED-CEADCPEGRWGLGCQEICPACQHAARCDPETG 800
Query: 348 RGSCKETSLGFECE--CSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWT 405
C +G C+ C GW GP+C T CS C++ G C C C P WT
Sbjct: 801 ACLCLPGFVGSRCQDVCPAGWYGPSCQTR---CS---CANDGHCHPATG--HCSCAPGWT 852
Query: 406 GKTCQLDAN------ECEAKPC---VNAKSCKNLIASYYCDCLPGWMGQNCDININ---- 452
G +CQ + +C + PC SC + S C C G++G C+
Sbjct: 853 GFSCQRACDTGHWGPDC-SHPCNCSAGHGSCDAI--SGLCLCEAGYVGPRCEQQCPQGHF 909
Query: 453 ----DCLGQCQNDASCRDLVNGYRCICPPGYAGDHCER-------DIDECASNPCLNGGH 501
+ QCQ+ A+C D V+G C CP G+ G CE +D ++ C G
Sbjct: 910 GPGCEQRCQCQHGAAC-DHVSG-ACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAA 967
Query: 502 CQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCS 561
C + +N CLCP G G C E P A Y C C + G +C
Sbjct: 968 C-DAVNG-SCLCPAGRRGPRC------AETCP----AHTYGHNCSQACAC---FNGASCD 1012
Query: 562 HLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGF 621
+ C P + SC A + + R+ S +C G C SG C C +G+
Sbjct: 1013 PVHGQCHCAPGWMGPSCLQACPAGLYGDNCRH--SCLCQNGGTCDPVSG---HCACPEGW 1067
Query: 622 TGTYCHENI--NDCESNPCRNGGTCIDG----VNSYKCICSDGWEGAYCETNINDCSQNP 675
G C + D + CR+ G C++G ++ +C+C GW G C++
Sbjct: 1068 AGLACEKECLPRDVRAG-CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQS--------- 1117
Query: 676 CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW 735
C GW G+ C R +C G C+ A C CP G+
Sbjct: 1118 ----------------PCLRGWFGEACAQR------CSCPPGAACHHVTGA--CRCPPGF 1153
Query: 736 EGTTCNIARNSSCLPNPCHNGGTC-----VVNGESFTCVCKEGWEGPICAQNTNDCSPH- 789
G+ C A C C + + TC C G+ GP C Q C P
Sbjct: 1154 TGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQR---CPPGR 1210
Query: 790 ---------PCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP-------CAFGA 833
C N G+C C C GF G DC + + + P C GA
Sbjct: 1211 YGPGCEQLCGCLNGGSCDAATG--ACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA 1268
Query: 834 TCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNT---CQCLNGRI 890
C D + G C+CPPG +G +C+ G P G G + C C NG
Sbjct: 1269 AC-DPVTG-TCLCPPGRAGVRCER--GCPQNRFGV----GCEHTCSCRNGGLCHASNGSC 1320
Query: 891 ACSKVWCGPRPCLLHKGHSECPSGQ 915
+C W G R C L CP G+
Sbjct: 1321 SCGLGWTG-RHCEL-----ACPPGR 1339
Score = 211 bits (536), Expect = 4e-54
Identities = 233/773 (30%), Positives = 284/773 (36%), Gaps = 199/773 (25%)
Query: 220 CMEGWMGPECNRAI--CRQGCSPKHGSCKLPGD-CRCQYGWQGLYCDKCIPHPGCVHGIC 276
C++ G +C+ CR G G+C L D C C GW GL IC
Sbjct: 511 CLDDSFGHDCSLTCDDCRNG-----GTCLLGLDGCDCPEGWTGL--------------IC 551
Query: 277 NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSN-TGPDKYQCSCPEGYSGPNCE- 334
NE C + G+ C + C NGGTC + TG C CP G SG NCE
Sbjct: 552 NET----CPPDTFGKNCSFSCS-------CQNGGTCDSVTGA----CRCPPGVSGTNCED 596
Query: 335 ------IAEHACLSDPCHNRGSCKETSLGFECECSPG------------WT-GPTCSTNI 375
+H C NRG C L C C PG W GP CS
Sbjct: 597 GCPKGYYGKHCRKKCNCANRGRCHR--LYGACLCDPGLYGRFCHLTCPPWAFGPGCSEEC 654
Query: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECE----AKPCVNAKSCKNLI 431
P H +C D +G C C + G+ CQ ECE C A +C +
Sbjct: 655 QCVQP----HTQSC-DKRDG-SCSCKAGFRGERCQA---ECELGYFGPGCWQACTCPVGV 705
Query: 432 ASYYCDCLPGWMGQNCDININ--DCLGQ----------CQNDASCRDL----VNGYRCIC 475
A CD + G G+ C DC GQ C + SC V G +C C
Sbjct: 706 A---CDSVSGECGKRCPAGFQGEDC-GQECPVGTFGVNCSSSCSCGGAPCHGVTG-QCRC 760
Query: 476 PPGYAGDHCERDIDE------CAS--NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDID 527
PPG G+ CE D E C C + C E CLC GF G+ CQ D
Sbjct: 761 PPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETG--ACLCLPGFVGSRCQ---D 815
Query: 528 YCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDT 587
C G C R C C D +C HC P SC A +
Sbjct: 816 VCPAG--WYGPSCQTR-----CSCAND---GHCHPATGHCSCAPGWTGFSCQRACDTGHW 865
Query: 588 PEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND------CESN-PCRN 640
+ N HG C + SG C C G+ G C + CE C++
Sbjct: 866 GPDCSH-PCNCSAGHGSCDAISG---LCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQH 921
Query: 641 GGTCIDGVNSYKCICSDGWEGAYCETNIN------DC-SQNPCHNGGTCRDLVNDFYCDC 693
G C D V S C C GW G +CE DC S C G C D VN C C
Sbjct: 922 GAAC-DHV-SGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC-DAVNG-SCLC 977
Query: 694 KNGWKGKTC------HSRDSQCDEA-TCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA--- 743
G +G C H+ C +A C NG +C + +C C GW G +C A
Sbjct: 978 PAGRRGPRCAETCPAHTYGHNCSQACACFNGASC--DPVHGQCHCAPGWMGPSCLQACPA 1035
Query: 744 ------RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHP----CYN 793
SCL C NGGTC + S C C EGW G C + +C P C +
Sbjct: 1036 GLYGDNCRHSCL---CQNGGTC--DPVSGHCACPEGWAGLACEK---ECLPRDVRAGCRH 1087
Query: 794 SGTCVDG----DNWYRCECAPGFAGPDCRININECQSSPCA---FGATCVDEINGYRCVC 846
SG C++G + RC C G+ G C+ SPC FG C RC C
Sbjct: 1088 SGGCLNGGLCDPHTGRCLCPAGWTGDKCQ--------SPCLRGWFGEACAQ-----RCSC 1134
Query: 847 PPGHSGAKCQEVSGRPCITMG-------SVIPDGAKWDDDCNTCQCLNGRIAC 892
PP GA C V+G G P G+ +D CQC AC
Sbjct: 1135 PP---GAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPAC 1184
Score = 207 bits (528), Expect = 4e-53
Identities = 205/774 (26%), Positives = 267/774 (34%), Gaps = 188/774 (24%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQG--------- 237
C +YG C C +D H A G+ +C GW G C RA C G
Sbjct: 817 CPAGWYGPSCQTRCSCANDGHCHPA---TGHCSCAPGWTGFSCQRA-CDTGHWGPDCSHP 872
Query: 238 --CSPKHGSCK-LPGDCRCQYGWQGLYCDKCIPH----PGCV------HGICNE--PWQC 282
CS HGSC + G C C+ G+ G C++ P PGC HG + C
Sbjct: 873 CNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGAC 932
Query: 283 LCETNWGGQLCDKDLNY------CGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNC--- 333
C W G C+ C + C G C C CP G GP C
Sbjct: 933 TCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGS---CLCPAGRRGPRCAET 989
Query: 334 ---EIAEHACLSD-PCHNRGSCKETSLGFECECSPGWTGPTCSTNI------DDCSPN-N 382
H C C N SC +C C+PGW GP+C D+C +
Sbjct: 990 CPAHTYGHNCSQACACFNGASCDPVH--GQCHCAPGWMGPSCLQACPAGLYGDNCRHSCL 1047
Query: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP-------CVNAKSCKNLIASYY 435
C +GGTC D V+G C CP W G C+ + + + C+N C
Sbjct: 1048 CQNGGTC-DPVSG-HCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCL 1105
Query: 436 C-----------DCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHC 484
C CL GW G+ C C C A+C + C CPPG+ G C
Sbjct: 1106 CPAGWTGDKCQSPCLRGWFGEAC---AQRC--SCPPGAACHHVTGA--CRCPPGFTGSGC 1158
Query: 485 ERDI------DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPN------ 532
E+ ++CA G + C C G+ G CQ C P
Sbjct: 1159 EQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQ---QRCPPGRYGPGC 1215
Query: 533 ----PCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C NG C A+ C+CP + G +C+ R P +CT
Sbjct: 1216 EQLCGCLNGGSC--DAATGACRCPTGFLGTDCNLTCPQGRFGP-----NCTHVCG----- 1263
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND------CESN-PCRNG 641
CG C +G TC C G G C CE CRNG
Sbjct: 1264 ----------CGQGAACDPVTG---TCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNG 1310
Query: 642 GTCIDGVNSYKCICSDGWEGAYCETNIN----------DCSQNPCHNGGTCRDLVNDFYC 691
G C ++ C C GW G +CE +CS CHN TC C
Sbjct: 1311 GLC--HASNGSCSCGLGWTGRHCELACPPGRYGAACHLECS---CHNNSTCEPATGT--C 1363
Query: 692 DCKNGWKGKTC--------HSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA 743
C G+ G+ C H Q C +G C + + +C+CP G+ G C
Sbjct: 1364 RCGPGFYGQACEHPCPPGFHGAGCQ-GLCWCQHGAPC--DPISGRCLCPAGFHGHFCERG 1420
Query: 744 RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW 803
CH C C G C T C P + TC
Sbjct: 1421 CEPGSFGEGCHQ-----------RCDCD---GGAPCDPVTGLCLCPPGRSGATC------ 1460
Query: 804 YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQE 857
+C G GP C ++ + C GA C D ++G +C C G+ G C+E
Sbjct: 1461 -NLDCRRGQFGPSCTLHCD------CGGGADC-DPVSG-QCHCVDGYMGPTCRE 1505
Score = 199 bits (507), Expect = 1e-50
Identities = 191/733 (26%), Positives = 261/733 (35%), Gaps = 155/733 (21%)
Query: 158 SGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFC----------RPRDDFF 207
+G PS Q + N G H +C + GF C + C P +
Sbjct: 819 AGWYGPSCQTRCSCANDGHCH-PATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSA 877
Query: 208 GHYACDQ-NGNKTCMEGWMGPECNRAI--------CRQGCSPKHGSC--KLPGDCRCQYG 256
GH +CD +G C G++GP C + C Q C +HG+ + G C C G
Sbjct: 878 GHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAG 937
Query: 257 WQGLYCDKCIPHP----------GCVHGICNEP--WQCLCETNWGGQLCDKDL------N 298
W+G +C+ P C G + CLC G C + +
Sbjct: 938 WRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGH 997
Query: 299 YCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNC----------EIAEHACLSDPCHNR 348
C C NG +C P QC C G+ GP+C + H+CL C N
Sbjct: 998 NCSQACACFNGASCD---PVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCL---CQNG 1051
Query: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN----CSHGGTCQDLVNGF-------K 397
G+C S C C GW G C +C P + C H G C +NG +
Sbjct: 1052 GTCDPVS--GHCACPEGWAGLACEK---ECLPRDVRAGCRHSGGC---LNGGLCDPHTGR 1103
Query: 398 CVCPPQWTGKTCQLDA-NECEAKPCVNAKSCKNLIASYY----CDCLPGWMGQNCDINI- 451
C+CP WTG CQ + C SC A ++ C C PG+ G C+
Sbjct: 1104 CLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACP 1163
Query: 452 -----NDCLGQCQ---NDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP-------C 496
DC CQ + +C C C GY G C++ P C
Sbjct: 1164 PGSFGEDCAQMCQCPGENPACHPATG--TCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGC 1221
Query: 497 LNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYE 556
LNGG C C CPTGF G C L C G + + C C +
Sbjct: 1222 LNGGSCDAATGA--CRCPTGFLGTDCNLT--------CPQGR--FGPNCTHVCGCGQ--- 1266
Query: 557 GKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCD 616
G C + C P C N G + S C G C + +G +C
Sbjct: 1267 GAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCS--CRNGGLCHASNG---SCS 1321
Query: 617 CNKGFTGTYCHENIND------CESN-PCRNGGTCIDGVNSYKC-----------ICSDG 658
C G+TG +C C C N TC + +C C G
Sbjct: 1322 CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG 1381
Query: 659 WEGAYCETNINDCSQ----NPCHNGGTCRDLVNDFYCD--CKNGWKGKTCHSRDSQCDEA 712
+ GA C+ + C +P C + +C+ C+ G G+ CH R CD
Sbjct: 1382 FHGAGCQ-GLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQR---CD-- 1435
Query: 713 TCNNGGTCYDEGDAFKCMCPGGWEGTTCNI-ARNSSCLPN---PCHNGGTCVVNGESFTC 768
C+ G C + C+CP G G TCN+ R P+ C GG + S C
Sbjct: 1436 -CDGGAPC--DPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQC 1492
Query: 769 VCKEGWEGPICAQ 781
C +G+ GP C +
Sbjct: 1493 HCVDGYMGPTCRE 1505
Score = 194 bits (493), Expect = 4e-49
Identities = 217/819 (26%), Positives = 291/819 (35%), Gaps = 186/819 (22%)
Query: 222 EGWMGPECNRAICRQGCSPKHGSCKLPGD---CRCQYGWQGLYC----DKCIPHPG-CVH 273
EG + EC+ ++C G G C +PG C C G+QG C D+C H G C H
Sbjct: 121 EGCLSAECSASLCFHG-----GRC-VPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQH 174
Query: 274 GICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCL--NGGT---CSNTGPDKYQCSCPEGY 328
N P LCE G +L D C C NGG C +++C C G+
Sbjct: 175 RCVNTPGSYLCECKPGFRL-HTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGF 233
Query: 329 SGPNCEIAEHACLSDPCHNR-GSCK---ETSLGF-ECECSPGW----TGPTCSTNIDDCS 379
E H PC NR GSC + G CEC G+ G C ++D+C+
Sbjct: 234 QLQ--EDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE-DVDECA 290
Query: 380 PN--NCSHGGTCQDLVNGFKCVCPPQW----TGKTC---QLD-ANECEAKPCVNAKSCKN 429
C+HG C + FKCVC + G+ C +++ N CEA + C +
Sbjct: 291 AGLAQCAHG--CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSH 348
Query: 430 LIASYYCDCLPGW---MGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGY--AGDHC 484
A C C G+ Q I+++DC C + GY C C GY + D C
Sbjct: 349 TSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGC 408
Query: 485 E-RDIDECASNPCLNGGHCQNEINRFQCLCPTGF------------SGNLCQLDIDYCEP 531
D+DECAS+ HC N FQC C G+ + LD +
Sbjct: 409 GCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFV 468
Query: 532 NPCQNGAQCYNRASDYF-----------------------CKCPEDYEGKNCSHLKDHCR 568
P + A + F C +D G +CS D CR
Sbjct: 469 RPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCR 528
Query: 569 TTPCEVIDSCTVAMASNDTPEG-VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
+C + + D PEG I + C P K+ S F+C C G T C
Sbjct: 529 NG-----GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCS---FSCSCQNGGT---CD 577
Query: 628 ENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVN 687
C P +G C DG C G+ G +C N C N G C L
Sbjct: 578 SVTGACRCPPGVSGTNCEDG-------CPKGYYGKHCRKKCN------CANRGRCHRLYG 624
Query: 688 DFYCDCKNGWKGKTCH------------SRDSQC----DEATCNNGGTCYDE----GDAF 727
C C G G+ CH S + QC ++ G+C + G+
Sbjct: 625 --ACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERC 682
Query: 728 KCMC------PGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
+ C PG W+ TC + + C GE C G G C+
Sbjct: 683 QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSS 742
Query: 782 NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININE------CQS--SPCAFGA 833
+ + C PC+ V G +C C PG G DC + E CQ C A
Sbjct: 743 SCS-CGGAPCHG----VTG----QCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAA 793
Query: 834 TCVDEINGYRCVCPPGHSGAKCQEVS-----GRPCITMGSVIPDGAKWDDDCNTCQCLNG 888
C E C+C PG G++CQ+V G C T S DG C G
Sbjct: 794 RCDPETGA--CLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDG--------HCHPATG 843
Query: 889 RIACSKVWCG----------------PRPCLLHKGHSEC 911
+C+ W G PC GH C
Sbjct: 844 HCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSC 882
Score = 69.7 bits (169), Expect = 2e-11
Identities = 59/216 (27%), Positives = 87/216 (40%), Gaps = 29/216 (13%)
Query: 745 NSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
++ C + C +GG CV G + C C G++GP C + ++C H CV+ Y
Sbjct: 125 SAECSASLCFHGGRCVP-GSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSY 183
Query: 805 RCECAPGF-AGPDCR--ININECQSSPCAFGATCVD-EINGYRCVCPPGHSGAKCQEVSG 860
CEC PGF D R + IN C CV I +RC C PG + QE G
Sbjct: 184 LCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGF---QLQE-DG 239
Query: 861 RPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPI 920
R C+ P + + CQ + G C H G+ G++C +
Sbjct: 240 RHCVRRS---PCANRNGSCMHRCQVVRGLARCE----------CHVGYQLAADGKACEDV 286
Query: 921 LDDQCFVHPCTGVGECRSSSLQPVKT-KCTSDSYYQ 955
D+C G+ +C L + KC + Y+
Sbjct: 287 --DEC----AAGLAQCAHGCLNTQGSFKCVCHAGYE 316
Score = 66.6 bits (161), Expect = 1e-10
Identities = 73/301 (24%), Positives = 109/301 (36%), Gaps = 92/301 (30%)
Query: 693 CKNGWKGKTCHSR--DSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLP 750
C GW + ++C + C +GG C G A C CP G++G C +
Sbjct: 110 CCRGWMQQPDEEGCLSAECSASLCFHGGRCVP-GSAQPCHCPPGFQGPRCQYDVDEC--- 165
Query: 751 NPCHNGG---TCVVNGESFTCVCKEGWEGPI----------CAQNTNDCSPH-------- 789
HNGG CV S+ C CK G+ CA C H
Sbjct: 166 -RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITR 224
Query: 790 ----------------------PCYN-SGTCVDGDNWYRCECAPGFAGPDCRI------- 819
PC N +G+C+ +RC+ G A +C +
Sbjct: 225 HRCQCRPGFQLQEDGRHCVRRSPCANRNGSCM-----HRCQVVRGLARCECHVGYQLAAD 279
Query: 820 -----NINECQS--SPCAFGATCVDEINGYRCVCPPGHS-GAKCQEVSGRPCITMGSVIP 871
+++EC + + CA G C++ ++CVC G+ GA GR C + I
Sbjct: 280 GKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYELGA-----DGRQCYRIEMEI- 331
Query: 872 DGAKWDDDCNTCQCLNGRIA--CSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHP 929
N+C+ NG + CS GP C +G+ ++CI + D C P
Sbjct: 332 --------VNSCEANNGGCSHGCSHTSAGPL-CTCPRGYELDTDQRTCIDV--DDCADSP 380
Query: 930 C 930
C
Sbjct: 381 C 381
>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
Length = 4242
Score = 233 bits (594), Expect = 8e-61
Identities = 189/650 (29%), Positives = 256/650 (39%), Gaps = 110/650 (16%)
Query: 216 GNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGI 275
G C G+ GP C C C + G C + G C C+ G+ G C + GC
Sbjct: 200 GRCVCFPGYTGPSCGWPSCPGDCQGR-GRC-VQGVCVCRAGFSGPDCSQRSCPRGCSQRG 257
Query: 276 CNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
E +C+C+ + G C + C + C G C N +C C GY+G +C +
Sbjct: 258 RCEGGRCVCDPGYTGDDCG--MRSCP--RGCSQRGRCENG-----RCVCNPGYTGEDCGV 308
Query: 336 AEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG 395
+C C RG CK+ C C PG+TG C T P +C GG C D
Sbjct: 309 --RSCPRG-CSQRGRCKDG----RCVCDPGYTGEDCGTR---SCPWDCGEGGRCVD---- 354
Query: 396 FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCL 455
+CVC P +TG+ +C + C + C C G+ G +C + C
Sbjct: 355 GRCVCWPGYTGE-------DCSTRTCPRDCRGRGRCEDGECICDTGYSGDDC--GVRSCP 405
Query: 456 GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPT 515
G C C D RC+C PGY G C C G C+N + C+C
Sbjct: 406 GDCNQRGRCED----GRCVCWPGYTGTDCG---SRACPRDCRGRGRCENGV----CVCNA 454
Query: 516 GFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSH--LKDHCRTTPCE 573
G+SG C + C P C+ +C + C C Y G++C CR
Sbjct: 455 GYSGEDC--GVRSC-PGDCRGRGRCESGR----CMCWPGYTGRDCGTRACPGDCRGRGRC 507
Query: 574 VIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDC 633
V C G R + C HG C+ C C+ G++G C + C
Sbjct: 508 VDGRCVCNPGFTGEDCGSRRCPGD-CRGHGLCEDG-----VCVCDAGYSGEDC--STRSC 559
Query: 634 ESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI--NDCSQNPCHNGGTCRDLVNDFYC 691
CR G C+DG +C+C DG+ G C NDCSQ+ G C+D V C
Sbjct: 560 PGG-CRGRGQCLDG----RCVCEDGYSGEDCGVRQCPNDCSQH-----GVCQDGV----C 605
Query: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN 751
C G+ + C R + C+ G C +EG +C+C G+ G TC + P
Sbjct: 606 ICWEGYVSEDCSIRTCP---SNCHGRGRC-EEG---RCLCDPGYTGPTCA----TRMCPA 654
Query: 752 PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHP--CYNSGTCVDGDNWYRCECA 809
C G CV C+C G+ G C Q S P C C G +C C
Sbjct: 655 DCRGRGRCVQG----VCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAG----QCVCV 706
Query: 810 PGFAGPDCRININECQSSP--CAFGATCVDEINGYRCVCPPGHSGAKCQE 857
GF GPDC I Q+ P C C D CVC G++G C E
Sbjct: 707 EGFRGPDCAI-----QTCPGDCRGRGECHDG----SCVCKDGYAGEDCGE 747
Score = 223 bits (569), Expect = 7e-58
Identities = 199/734 (27%), Positives = 271/734 (36%), Gaps = 168/734 (22%)
Query: 234 CRQGCSPKHGS-----------CKLPG-------DCRCQYGWQGLYC----DKCIP--HP 269
C GC P C L G C C+ GW G C D IP P
Sbjct: 121 CTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSP 180
Query: 270 GCVHGICNEP---------WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320
G C + +C+C + G C + C G C +
Sbjct: 181 PSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSC----GWPSCPGDCQGRGRCV-----QG 231
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380
C C G+SGP+C ++ +C C RG C+ G C C PG+TG C P
Sbjct: 232 VCVCRAGFSGPDC--SQRSC-PRGCSQRGRCE----GGRCVCDPGYTGDDCGMR---SCP 281
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLP 440
CS G C+ NG +CVC P +TG+ +C + C S + C C P
Sbjct: 282 RGCSQRGRCE---NG-RCVCNPGYTGE-------DCGVRSCPRGCSQRGRCKDGRCVCDP 330
Query: 441 GWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG 500
G+ G++C C C C D RC+C PGY G+ C C G
Sbjct: 331 GYTGEDC--GTRSCPWDCGEGGRCVD----GRCVCWPGYTGEDCS---TRTCPRDCRGRG 381
Query: 501 HCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
C++ +C+C TG+SG D C C R D C C Y G +C
Sbjct: 382 RCEDG----ECICDTGYSG-------DDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDC 430
Query: 561 SHL--------KDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK 612
+ C C C + D GVR + C G+C+S
Sbjct: 431 GSRACPRDCRGRGRCENGVC----VCNAGYSGEDC--GVRSCPGD-CRGRGRCESG---- 479
Query: 613 FTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCS 672
C C G+TG C C + CR G C+DG +C+C+ G+ G DC
Sbjct: 480 -RCMCWPGYTGRDC--GTRACPGD-CRGRGRCVDG----RCVCNPGFTG-------EDCG 524
Query: 673 QNPCHNGGTCR--DLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM 730
C G CR L D C C G+ G+ C +R C G C D +C+
Sbjct: 525 SRRC--PGDCRGHGLCEDGVCVCDAGYSGEDCSTRSC---PGGCRGRGQCLDG----RCV 575
Query: 731 CPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHP 790
C G+ G C + + PN C G C + C+C EG+ C+ T P
Sbjct: 576 CEDGYSGEDCGVRQ----CPNDCSQHGVC----QDGVCICWEGYVSEDCSIRT---CPSN 624
Query: 791 CYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGH 850
C+ G C +G RC C PG+ GP C + C + C CV + C+C G+
Sbjct: 625 CHGRGRCEEG----RCLCDPGYTGPTCATRM--CPAD-CRGRGRCVQGV----CLCHVGY 673
Query: 851 SGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLH----- 905
G C + S P G + C QC+ C + + GP C +
Sbjct: 674 GGEDCGQEE-----PPASACPGGCGPRELCRAGQCV-----CVEGFRGP-DCAIQTCPGD 722
Query: 906 -KGHSECPSGQSCI 918
+G EC G SC+
Sbjct: 723 CRGRGECHDG-SCV 735
Score = 194 bits (493), Expect = 4e-49
Identities = 176/604 (29%), Positives = 222/604 (36%), Gaps = 155/604 (25%)
Query: 360 CECSPGWTGPTCSTNID------------DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGK 407
C C PGW GPTCS D P++C+ G C V G +CVC P +TG
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRC---VRG-RCVCFPGYTGP 211
Query: 408 TCQLDA--NECEAKP-CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASC 464
+C + +C+ + CV C C G+ G +C C S
Sbjct: 212 SCGWPSCPGDCQGRGRCVQG----------VCVCRAGFSGPDCSQR------SCPRGCSQ 255
Query: 465 RDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQL 524
R G RC+C PGY GD C + C C G C+N +C+C G++G
Sbjct: 256 RGRCEGGRCVCDPGYTGDDC--GMRSCPRG-CSQRGRCENG----RCVCNPGYTG----- 303
Query: 525 DIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMAS 584
+ C C G R D C C Y G++C R+ P +
Sbjct: 304 --EDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCG-----TRSCPWD----------- 345
Query: 585 NDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTC 644
CG G+C C C G+TG C + C + CR G C
Sbjct: 346 --------------CGEGGRCVDG-----RCVCWPGYTGEDC--STRTCPRD-CRGRGRC 383
Query: 645 IDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS 704
DG +CIC G+ G +DC C R D C C G+ G C S
Sbjct: 384 EDG----ECICDTGYSG-------DDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGS 432
Query: 705 RDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE 764
R D C G C + C+C G+ G C + SC P C G C E
Sbjct: 433 RACPRD---CRGRGRC----ENGVCVCNAGYSGEDCGV---RSC-PGDCRGRGRC----E 477
Query: 765 SFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININEC 824
S C+C G+ G C T C P C G CVDG RC C PGF G DC C
Sbjct: 478 SGRCMCWPGYTGRDC--GTRAC-PGDCRGRGRCVDG----RCVCNPGFTGEDC--GSRRC 528
Query: 825 QSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQ 884
C C D + CVC G+SG C S R C P G + Q
Sbjct: 529 PGD-CRGHGLCEDGV----CVCDAGYSGEDC---STRSC-------PGGCR-----GRGQ 568
Query: 885 CLNGRIACSKVW----CGPRPCLLH-KGHSECPSGQSCI---PILDDQCFVHPCT----G 932
CL+GR C + CG R C H C G CI + + C + C G
Sbjct: 569 CLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDG-VCICWEGYVSEDCSIRTCPSNCHG 627
Query: 933 VGEC 936
G C
Sbjct: 628 RGRC 631
Score = 142 bits (357), Expect = 3e-33
Identities = 128/487 (26%), Positives = 176/487 (36%), Gaps = 94/487 (19%)
Query: 184 RVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHG 243
R CD Y G C P D G D G C G+ G +C+ C + C + G
Sbjct: 325 RCVCDPGYTGEDCGTRSCPWDCGEGGRCVD--GRCVCWPGYTGEDCSTRTCPRDCRGR-G 381
Query: 244 SCKLPGDCRCQYGWQGLYCD-KCIPHPGCVHGICNEPWQCLC-----ETNWGGQLCDKDL 297
C+ G+C C G+ G C + P G C E +C+C T+ G + C +D
Sbjct: 382 RCE-DGECICDTGYSGDDCGVRSCPGDCNQRGRC-EDGRCVCWPGYTGTDCGSRACPRD- 438
Query: 298 NYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG 357
C G C N C C GYSG +C + +C D C RG C+
Sbjct: 439 --------CRGRGRCENG-----VCVCNAGYSGEDCGV--RSCPGD-CRGRGRCESG--- 479
Query: 358 FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQ------- 410
C C PG+TG C T P +C G C D +CVC P +TG+ C
Sbjct: 480 -RCMCWPGYTGRDCGTR---ACPGDCRGRGRCVD----GRCVCNPGFTGEDCGSRRCPGD 531
Query: 411 -----------------LDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD 453
+C + C + C C G+ G++C +
Sbjct: 532 CRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVR--- 588
Query: 454 CLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC 513
QC ND S + CIC GY + C I C SN C G C+ +CLC
Sbjct: 589 ---QCPNDCSQHGVCQDGVCICWEGYVSEDCS--IRTCPSN-CHGRGRCEEG----RCLC 638
Query: 514 PTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTP-- 571
G++G C + C P C+ +C C C Y G++C + P
Sbjct: 639 DPGYTGPTCATRM--C-PADCRGRGRCVQGV----CLCHVGYGGEDCGQEEPPASACPGG 691
Query: 572 CEVIDSCT----VAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
C + C V + P+ C G+C S C C G+ G C
Sbjct: 692 CGPRELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGECHDGS-----CVCKDGYAGEDCG 746
Query: 628 ENINDCE 634
E + E
Sbjct: 747 EEVPTIE 753
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 225 bits (574), Expect = 2e-58
Identities = 217/805 (26%), Positives = 297/805 (36%), Gaps = 186/805 (23%)
Query: 181 YQIRVTCDDYYYGFGCNKFCRPR-DDFFGHYACDQNGNKTCMEGWMGPECNRAI------ 233
Y+ R C YY G FC P + H C C GW GP+C+
Sbjct: 82 YRRRSQCCPGYYESG--DFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWG 139
Query: 234 --CRQGCSPKHGSCKLP--GDCRCQYGWQGLYCDK-CIPHP---------GCVHGICNEP 279
C C ++G+ P G C C G++G C++ C P C HG +P
Sbjct: 140 PHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDP 199
Query: 280 --WQCLCETNWGGQLCDK------DLNYCGTHQPCLNGGTCSN-TGPDKYQCSCPEGYSG 330
+CLC + G C++ +C PC NGGTC + TG +C+CP G++G
Sbjct: 200 RAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITG----ECACPPGWTG 255
Query: 331 PNC-------EIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNID------D 377
C ++ PCH+ G C + +C C+ G+ G C
Sbjct: 256 AVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVT--GQCHCTAGYMGDRCQEECPFGSFGFQ 313
Query: 378 CSPN-NCSHGGTCQDLVNGFKCVCPPQWTGKTCQ-------LDANECEAK-PC--VNAKS 426
CS + +C +GG C C C P + G CQ L C PC N S
Sbjct: 314 CSQHCDCHNGGQCSPTTGA--CECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTIS 371
Query: 427 CKNLIASYYCDCLPGWMGQNCDINI------NDCL--GQCQNDASCRDLVNGYRCICPPG 478
C + + C C PGW G +C+ + + C CQN A C + G C C PG
Sbjct: 372 CHPVTGA--CTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG--CTCAPG 427
Query: 479 YAGDHCERDIDECASNP-------CLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP 531
+ G+ C P C NGG C C C G+ G C L
Sbjct: 428 FMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDG--SCTCKEGWQGLDCTL------- 478
Query: 532 NPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGV 591
PC +G N + C C G CS + C TP + D+C + P+G
Sbjct: 479 -PCPSGTWGLN--CNESCTCA---NGAACSPIDGSCSCTPGWLGDTCEL-----PCPDGT 527
Query: 592 RYISSNVCGPHGKCKSQSGGKFT---CDCNKGFTGTYCHENI-------NDCESNPCRNG 641
++ C H C G C C G+TG C N S C NG
Sbjct: 528 FGLN---CSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENG 584
Query: 642 GTCIDGVNSYKCICSDGWEGAYCETNI------NDCSQNPC----HNGGTCRDLVNDFYC 691
G+C S C C+ G+ G C+ + C+Q PC H+ C + C
Sbjct: 585 GSCSPEDGS--CECAPGFRGPLCQRICPPGFYGHGCAQ-PCPLCVHSSRPCHHISG--IC 639
Query: 692 DCKNGWKGKTCHS------RDSQCDE-ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR 744
+C G+ G C+ C + +C N GTC + C C GW G C
Sbjct: 640 ECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGS--CQCFPGWIGKDC---- 693
Query: 745 NSSCLPN----------PCHNGGTCVVNGESFTCVCKEGWEGPICAQNT------NDCS- 787
+ +C P CHNG +C + E C C GW G C Q DC
Sbjct: 694 SQACPPGFWGPACFHACSCHNGASC--SAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGR 751
Query: 788 PHPCYNSGTC--VDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATC---------- 835
C N +C + G +C C GF G C E + +P FG C
Sbjct: 752 VCQCQNGASCDHISG----KCTCRTGFTGQHC-----EQRCAPGTFGYGCQQLCECMNNS 802
Query: 836 -VDEINGYRCVCPPGHSGAKCQEVS 859
D + G C C PG G +C + +
Sbjct: 803 TCDHVTG-TCYCSPGFKGIRCDQAA 826
Score = 224 bits (570), Expect = 5e-58
Identities = 226/798 (28%), Positives = 290/798 (36%), Gaps = 212/798 (26%)
Query: 263 DKCIP--HPGCVHGICNEPWQCLCETNWGGQLCDKDLN------YCGTHQPCLNGGTCSN 314
D CIP CVHG C P C CE WGG C + +C C NG C+
Sbjct: 97 DFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCN- 155
Query: 315 TGPDKYQCSCPEGYSGPNCEIAEHACLSD--------PCHNRGSCKETSLGFECECSPGW 366
P C C G+ G C E C PC R EC C+PG+
Sbjct: 156 --PITGACVCAAGFRGWRC---EELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGY 210
Query: 367 TGPTCSTNIDDCSPNN----------CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANEC 416
TG C + C P + C +GGTC + +C CPP WTG C
Sbjct: 211 TGVYCE---ELCPPGSHGAHCELRCPCQNGGTCHHITG--ECACPPGWTGAVC------- 258
Query: 417 EAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICP 476
A+PC PG GQNC DC C + C D V G +C C
Sbjct: 259 -AQPCP-----------------PGTFGQNCS---QDC--PCHHGGQC-DHVTG-QCHCT 293
Query: 477 PGYAGDHCERDID------ECASN-PCLNGGHCQNEINRFQC------------LCPTGF 517
GY GD C+ + +C+ + C NGG C +C LCP G
Sbjct: 294 AGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGL 353
Query: 518 SGNLCQLDIDYCEPN-----PCQNGAQCYNRASDYFC--KCPEDY------------EGK 558
G C L N P C S + C CP Y G
Sbjct: 354 HGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGA 413
Query: 559 NCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCN 618
+C + C P + + C V+ A+ I S C G C G +C C
Sbjct: 414 DCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICS--CNNGGTCSPVDG---SCTCK 468
Query: 619 KGFTGTYC-------HENINDCESNPCRNGGTC--IDGVNSYKCICSDGWEGAYCETNIN 669
+G+ G C +N ES C NG C IDG C C+ GW G CE
Sbjct: 469 EGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDG----SCSCTPGWLGDTCELPCP 524
Query: 670 D------CSQN-PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCD----------EA 712
D CS++ C + C + +C C GW G C DS C
Sbjct: 525 DGTFGLNCSEHCDCSHADGCDPVTG--HCCCLAGWTGIRC---DSTCPPGRWGPNCSVSC 579
Query: 713 TCNNGGTCYDEGDAFKC-----------MCPGGWEG----TTCNIARNSSCLPNPCHN-G 756
+C NGG+C E + +C +CP G+ G C + +SS PCH+
Sbjct: 580 SCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSS---RPCHHIS 636
Query: 757 GTCV----VNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTC--VDGDNWYRCECAP 810
G C +G VC G+ G CAQ CS C N+GTC +DG C+C P
Sbjct: 637 GICECLPGFSGALCNQVCAGGYFGQDCAQL---CS---CANNGTCSPIDGS----CQCFP 686
Query: 811 GFAGPDCRININECQSSPCAF-GATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMG-- 867
G+ G DC Q+ P F G C + C C H+GA C G T G
Sbjct: 687 GWIGKDC------SQACPPGFWGPACF-----HACSC---HNGASCSAEDGACHCTPGWT 732
Query: 868 ----SVIPDGAKWDDDC-NTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILD 922
+ A + DC CQC NG +C + C G + Q C P
Sbjct: 733 GLFCTQRCPAAFFGKDCGRVCQCQNG-ASCDHI---SGKCTCRTGFTGQHCEQRCAP--- 785
Query: 923 DQCFVHPCTGVGECRSSS 940
F + C + EC ++S
Sbjct: 786 -GTFGYGCQQLCECMNNS 802
Score = 170 bits (431), Expect = 7e-42
Identities = 195/782 (24%), Positives = 261/782 (33%), Gaps = 240/782 (30%)
Query: 389 CQDLVNGFKCV------------------------CPPQW-TGKTC-QLDANECEAKPCV 422
C D++N FKC CP + +G C L EC CV
Sbjct: 54 CTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCV 113
Query: 423 NAKSCKNLIASYYCDCLPGWMGQNCDINI----------NDCLGQCQNDASCRDLVNGYR 472
+ + C C PGW G +C N C QCQN A C +
Sbjct: 114 SPDT---------CHCEPGWGGPDCSSGCDSDHWGPHCSNRC--QCQNGALCNPITGA-- 160
Query: 473 CICPPGYAGDHCERDIDECASN----------PCLNGGHCQNEINRFQCLCPTGFSGNLC 522
C+C G+ G CE + CA C +G C +CLC G++G C
Sbjct: 161 CVCAAGFRGWRCE---ELCAPGTHGKGCQLPCQCRHGASCDPRAG--ECLCAPGYTGVYC 215
Query: 523 QLDIDYCEPN----------PCQNGAQCYNRASDYFC-----------KCPEDYEGKNCS 561
+ + C P PCQNG C++ + C CP G+NCS
Sbjct: 216 E---ELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCS 272
Query: 562 ------------HLKDHCRTTPCEVIDSCTVAMASNDTPEG-VRYISSNVCGPH--GKCK 606
H+ C T + D C + P G + S C H G+C
Sbjct: 273 QDCPCHHGGQCDHVTGQCHCTAGYMGDRC-----QEECPFGSFGFQCSQHCDCHNGGQCS 327
Query: 607 SQSGGKFTCDCNKGFTGTYCHENINDCESN----------PCRNGGTCIDGVNSYKCICS 656
+G C+C G+ G C E + C PC T + C C
Sbjct: 328 PTTG---ACECEPGYKGPRCQERL--CPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQ 382
Query: 657 DGWEGAYCETN-----INDCSQNP--CHNGGTCRDLVNDFYCDCKNGWKGKTC------H 703
GW G +C + D Q P C NG C + C C G+ G+ C
Sbjct: 383 PGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAG 440
Query: 704 SRDSQCDE-ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN 762
+ C +CNNGGTC + C C GW+G C + S C+ TC N
Sbjct: 441 TYGPNCSSICSCNNGGTCSPVDGS--CTCKEGWQGLDCTLPCPSGTWGLNCNESCTC-AN 497
Query: 763 GESF-----TCVCKEGWEGPICAQNTND------CSPH---------------------- 789
G + +C C GW G C D CS H
Sbjct: 498 GAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGW 557
Query: 790 ----------------------PCYNSGTCVDGDNWYRCECAPGFAGPDCR-------IN 820
C N G+C D CECAPGF GP C+
Sbjct: 558 TGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDG--SCECAPGFRGPLCQRICPPGFYG 615
Query: 821 INECQSSP-CAFGATCVDEINGYRCVCPPGHSGAKCQEVS-----GRPCITMGSVIPDGA 874
Q P C + I+G C C PG SGA C +V G+ C + S +G
Sbjct: 616 HGCAQPCPLCVHSSRPCHHISGI-CECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGT 674
Query: 875 KWDDDCNTCQCLNGRI------ACSKVWCGP---RPCLLHKGHS--------ECPSGQS- 916
D +CQC G I AC + GP C H G S C G +
Sbjct: 675 CSPID-GSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTG 733
Query: 917 --CIPILDDQCFVHPCTGVGECRS-SSLQPVKTKCT-----SDSYYQDNCANITFTFNKE 968
C F C V +C++ +S + KCT + + + CA TF + +
Sbjct: 734 LFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQ 793
Query: 969 MM 970
+
Sbjct: 794 QL 795
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 225 bits (573), Expect = 2e-58
Identities = 89/235 (37%), Positives = 129/235 (54%), Gaps = 5/235 (2%)
Query: 220 CMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEP 279
C+ G G C C HG C G CRC GW+GL+C++C+ PGC HG C++P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHA 339
WQC+C + W G+ CDKD + C T PC NGG C G +Y C C G+ G +CE
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 340 C--LSDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN 394
C PC N G C++ +L F C C G+ G C N+DDC C++G TC D +N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 395 GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449
F C+CP + G+ C ++ ++C ++PC C++ + + C C G+ G+ C++
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 182 bits (463), Expect = 1e-45
Identities = 96/274 (35%), Positives = 130/274 (47%), Gaps = 50/274 (18%)
Query: 438 CLPGWMGQ-----NCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
C+ G GQ +C + + G C D SCR C PG+ G HCER C
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CV 61
Query: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP-NPCQNGAQC-YNRASDYFCK 550
P G C +QC+C +G++G C D C +PCQNG QC Y+ +Y C
Sbjct: 62 RMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCV 118
Query: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
C + G++C + PCE S C G+C+ G
Sbjct: 119 CLPGFHGRDCER-----KAGPCEQAGS--------------------PCRNGGQCQDDQG 153
Query: 611 G--KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668
FTC C GF G C N++DC PC NG TC+DG+N + C+C +G+ G +C N+
Sbjct: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
Query: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
+DC+ PC G CRD V+DF C C +G+ GKTC
Sbjct: 214 DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
Score = 169 bits (428), Expect = 1e-41
Identities = 90/236 (38%), Positives = 119/236 (50%), Gaps = 20/236 (8%)
Query: 631 NDCESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689
+DC S+ G C DG C C GWEG +CE C + P GTC +
Sbjct: 27 DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PW 75
Query: 690 YCDCKNGWKGKTCHSRDSQCD-EATCNNGGTC-YDEGDAFKCMCPGGWEGTTCNIARNSS 747
C C +GW GK C + C ++ C NGG C YD G + C+C G+ G C +
Sbjct: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGP 134
Query: 748 C--LPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
C +PC NGG C + +FTC C G+ G C N +DC PC N TC+DG N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 803 WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
+ C C GFAG C IN+++C S PC GA C D ++ + C+CP G+ G C+ V
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
Score = 169 bits (427), Expect = 2e-41
Identities = 90/269 (33%), Positives = 137/269 (50%), Gaps = 27/269 (10%)
Query: 271 CVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSG 330
C+H +C LC GQ D C +H L G C+ G C C G+ G
Sbjct: 7 CLHLVC-----LLCILGAPGQPVRAD--DCSSHCD-LAHGCCAPDG----SCRCDPGWEG 54
Query: 331 PNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN-CSHGGTC 389
+CE C+ P G+C + ++C C GW G C + C+ + C +GG C
Sbjct: 55 LHCE----RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
Query: 390 Q-DLVNGFKCVCPPQWTGKTCQLDANECE--AKPCVNAKSCKN---LIASYYCDCLPGWM 443
D + CVC P + G+ C+ A CE PC N C++ ++ C CL G++
Sbjct: 108 MYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFV 167
Query: 444 GQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHC 502
G C++N++DCL + C N A+C D +N + C+CP G+AG C ++D+CAS PC G C
Sbjct: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
Query: 503 QNEINRFQCLCPTGFSGNLCQLDIDYCEP 531
++ ++ F CLCP+G+ G C+L + +P
Sbjct: 228 RDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
Score = 131 bits (330), Expect = 3e-30
Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 41/237 (17%)
Query: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS-N 494
C C PGW G +C+ + + CQ+ +C ++CIC G+AG C++D C + +
Sbjct: 46 CRCDPGWEGLHCERCVR--MPGCQH-GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
Query: 495 PCLNGGHCQNEIN-RFQCLCPTGFSGNLCQLDIDYCEP--NPCQNGAQCYNR---ASDYF 548
PC NGG C + + C+C GF G C+ CE +PC+NG QC + A ++
Sbjct: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
Query: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ 608
C+C + G C D C PC +C +G+
Sbjct: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCL---------DGIN---------------- 194
Query: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
+F+C C +GF G +C N++DC S PC+ G C D V+ + C+C G+ G CE
Sbjct: 195 ---RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 81.3 bits (199), Expect = 5e-15
Identities = 66/203 (32%), Positives = 88/203 (43%), Gaps = 34/203 (16%)
Query: 757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816
G C +G +C C GWEG C + C P GTC ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 817 CRININECQS-SPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGA 874
C + + C + SPC G C+ + G Y CVC PG G C+ +G PC GS +G
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG-PCEQAGSPCRNGG 146
Query: 875 KWDDDCN-----TCQCLNG----RIACSKVWCGPRPCL--------LHKGHSECP---SG 914
+ DD TC+CL G R + C RPC +++ CP +G
Sbjct: 147 QCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
Query: 915 QSCIPILDDQCFVHPCTGVGECR 937
+ C LDD C PC CR
Sbjct: 207 RFCTINLDD-CASRPCQRGARCR 228
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 225 bits (573), Expect = 2e-58
Identities = 89/235 (37%), Positives = 129/235 (54%), Gaps = 5/235 (2%)
Query: 220 CMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEP 279
C+ G G C C HG C G CRC GW+GL+C++C+ PGC HG C++P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHA 339
WQC+C + W G+ CDKD + C T PC NGG C G +Y C C G+ G +CE
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 340 C--LSDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN 394
C PC N G C++ +L F C C G+ G C N+DDC C++G TC D +N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 395 GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449
F C+CP + G+ C ++ ++C ++PC C++ + + C C G+ G+ C++
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 182 bits (463), Expect = 1e-45
Identities = 96/274 (35%), Positives = 130/274 (47%), Gaps = 50/274 (18%)
Query: 438 CLPGWMGQ-----NCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
C+ G GQ +C + + G C D SCR C PG+ G HCER C
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CV 61
Query: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP-NPCQNGAQC-YNRASDYFCK 550
P G C +QC+C +G++G C D C +PCQNG QC Y+ +Y C
Sbjct: 62 RMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCV 118
Query: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
C + G++C + PCE S C G+C+ G
Sbjct: 119 CLPGFHGRDCER-----KAGPCEQAGS--------------------PCRNGGQCQDDQG 153
Query: 611 G--KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668
FTC C GF G C N++DC PC NG TC+DG+N + C+C +G+ G +C N+
Sbjct: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
Query: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
+DC+ PC G CRD V+DF C C +G+ GKTC
Sbjct: 214 DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
Score = 169 bits (428), Expect = 1e-41
Identities = 90/236 (38%), Positives = 119/236 (50%), Gaps = 20/236 (8%)
Query: 631 NDCESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689
+DC S+ G C DG C C GWEG +CE C + P GTC +
Sbjct: 27 DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PW 75
Query: 690 YCDCKNGWKGKTCHSRDSQCD-EATCNNGGTC-YDEGDAFKCMCPGGWEGTTCNIARNSS 747
C C +GW GK C + C ++ C NGG C YD G + C+C G+ G C +
Sbjct: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGP 134
Query: 748 C--LPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
C +PC NGG C + +FTC C G+ G C N +DC PC N TC+DG N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 803 WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
+ C C GFAG C IN+++C S PC GA C D ++ + C+CP G+ G C+ V
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
Score = 169 bits (427), Expect = 2e-41
Identities = 90/269 (33%), Positives = 137/269 (50%), Gaps = 27/269 (10%)
Query: 271 CVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSG 330
C+H +C LC GQ D C +H L G C+ G C C G+ G
Sbjct: 7 CLHLVC-----LLCILGAPGQPVRAD--DCSSHCD-LAHGCCAPDG----SCRCDPGWEG 54
Query: 331 PNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN-CSHGGTC 389
+CE C+ P G+C + ++C C GW G C + C+ + C +GG C
Sbjct: 55 LHCE----RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
Query: 390 Q-DLVNGFKCVCPPQWTGKTCQLDANECE--AKPCVNAKSCKN---LIASYYCDCLPGWM 443
D + CVC P + G+ C+ A CE PC N C++ ++ C CL G++
Sbjct: 108 MYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFV 167
Query: 444 GQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHC 502
G C++N++DCL + C N A+C D +N + C+CP G+AG C ++D+CAS PC G C
Sbjct: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
Query: 503 QNEINRFQCLCPTGFSGNLCQLDIDYCEP 531
++ ++ F CLCP+G+ G C+L + +P
Sbjct: 228 RDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
Score = 131 bits (330), Expect = 3e-30
Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 41/237 (17%)
Query: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS-N 494
C C PGW G +C+ + + CQ+ +C ++CIC G+AG C++D C + +
Sbjct: 46 CRCDPGWEGLHCERCVR--MPGCQH-GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
Query: 495 PCLNGGHCQNEIN-RFQCLCPTGFSGNLCQLDIDYCEP--NPCQNGAQCYNR---ASDYF 548
PC NGG C + + C+C GF G C+ CE +PC+NG QC + A ++
Sbjct: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
Query: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ 608
C+C + G C D C PC +C +G+
Sbjct: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCL---------DGIN---------------- 194
Query: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
+F+C C +GF G +C N++DC S PC+ G C D V+ + C+C G+ G CE
Sbjct: 195 ---RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 81.3 bits (199), Expect = 5e-15
Identities = 66/203 (32%), Positives = 88/203 (43%), Gaps = 34/203 (16%)
Query: 757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816
G C +G +C C GWEG C + C P GTC ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 817 CRININECQS-SPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGA 874
C + + C + SPC G C+ + G Y CVC PG G C+ +G PC GS +G
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG-PCEQAGSPCRNGG 146
Query: 875 KWDDDCN-----TCQCLNG----RIACSKVWCGPRPCL--------LHKGHSECP---SG 914
+ DD TC+CL G R + C RPC +++ CP +G
Sbjct: 147 QCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
Query: 915 QSCIPILDDQCFVHPCTGVGECR 937
+ C LDD C PC CR
Sbjct: 207 RFCTINLDD-CASRPCQRGARCR 228
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 221 bits (562), Expect = 4e-57
Identities = 211/772 (27%), Positives = 285/772 (36%), Gaps = 202/772 (26%)
Query: 263 DKCIPHPG--CVHGICNEPWQCLCETNWGGQLCDKDLN------YCGTHQPCLNGGTCSN 314
+ C+PH CVHG C P C CE WGG C + +C + C NG C+
Sbjct: 103 EMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCN- 161
Query: 315 TGPDKYQCSCPEGYSGPNCE-IAEHACLSDPCHNRGSCKETS----LGFECECSPGWTGP 369
P C C G+ G CE E + CH R C+ + + EC C PG+TG
Sbjct: 162 --PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGA 219
Query: 370 TCSTNIDDCSPNN----------CSHGGTCQDLVNGFKCVCPPQWTGKTC-------QLD 412
C D C P C +GG C + +C CP W G C +
Sbjct: 220 FCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEGRFG 274
Query: 413 ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC-----------LGQCQND 461
N + C N +C A+ C C PG+ G+ C ++C QC N
Sbjct: 275 KNCSQECQCHNGGTCD--AATGQCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNG 329
Query: 462 ASCRDLVNGYRCICPPGYAGDHCERDI-------DECASN-PC-LNGGHCQNEINRFQCL 512
C V+G C+C G+AG+ CE + +C PC L H + ++ +C
Sbjct: 330 GKCYH-VSG-ACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSG-ECA 386
Query: 513 CPTGFSGNLCQLDIDYCEPN----------PCQNGAQCYNRASDYFCKCPEDYEGKNCSH 562
C G+SG C + C P CQNGA C + C C ++G +CS
Sbjct: 387 CKPGWSGLYCN---ETCSPGFYGEACQQICSCQNGADCDSVTGK--CTCAPGFKGIDCS- 440
Query: 563 LKDHCRTTPCEV----IDSCTVAMASNDTPEGVRYISSNVCGP-HGKCKSQSGG---KFT 614
TPC + I+ + ND VC P G C ++G +
Sbjct: 441 -------TPCPLGTYGINCSSRCGCKNDA----------VCSPVDGSCTCKAGWHGVDCS 483
Query: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTC--IDGVNSYKCICSDGWEGAYCETNIND-- 670
C G G C+ C+ C NGG C +DG C C+ GW G CE D
Sbjct: 484 IRCPSGTWGFGCNLT---CQ---CLNGGACNTLDGT----CTCAPGWRGEKCELPCQDGT 533
Query: 671 ----CSQN-PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEAT----------CN 715
C++ C + C +C C GW G C DS C E C
Sbjct: 534 YGLNCAERCDCSHADGCHPTTG--HCRCLPGWSGVHC---DSVCAEGRWGPNCSLPCYCK 588
Query: 716 NGGTCYDEGDAFKCMCPGGWEGTTCNIA--------RNSSCLPNPCHNGGTCVVNGESFT 767
NG +C D C C G+ GTTC R S P H+ G C + +
Sbjct: 589 NGASC--SPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC--HHITGL 644
Query: 768 CVCKEGWEGPICAQ-------NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRIN 820
C C G+ G +C + N C N+GTC D C+C PG+ G DC
Sbjct: 645 CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDR--SCQCYPGWIGSDC--- 699
Query: 821 INECQSSPCA---FGATCVDEINGY----------RCVCPPGHSGAKCQE-----VSGRP 862
S PC +G C+ N + C C PG +G C + G+
Sbjct: 700 -----SQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKD 754
Query: 863 CITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSG 914
C + +GA D C C G + R C +CPSG
Sbjct: 755 CALI-CQCQNGADCDHISGQCTCRTGFMG--------RHC-----EQKCPSG 792
Score = 184 bits (468), Expect = 3e-46
Identities = 188/708 (26%), Positives = 242/708 (34%), Gaps = 172/708 (24%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAI--------CRQG 237
C+ YG C++ C+ ++ CD G C G+ G C C Q
Sbjct: 182 CEQGTYGNDCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQR 237
Query: 238 CSPKHGSC--KLPGDCRCQYGWQGLYC--------------DKCIPHPGCVHGICNEPW- 280
C ++G + G+C C GW G C +C H G G C+
Sbjct: 238 CPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNG---GTCDAATG 294
Query: 281 QCLCETNWGGQLCDKDLNY------CGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334
QC C + G+ C + C C+NGG C + C C G++G CE
Sbjct: 295 QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCE 351
Query: 335 I-----------AEHACLSDPCH--NRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPN 381
+ C PCH N SC S EC C PGW+G C+ + CSP
Sbjct: 352 ARLCPEGLYGIKCDKRC---PCHLENTHSCHPMS--GECACKPGWSGLYCN---ETCSPG 403
Query: 382 ----------NCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDAN------ECEAK-PCVNA 424
+C +G C D V G KC C P + G C C ++ C N
Sbjct: 404 FYGEACQQICSCQNGADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKND 461
Query: 425 KSCKNLIASYYCDCLPGWMGQNCDININ--------DCLGQCQNDASCRDLVNGYRCICP 476
C + S C C GW G +C I + QC N +C L C C
Sbjct: 462 AVCSPVDGS--CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDG--TCTCA 517
Query: 477 PGYAGDHCERDIDE------CASN-PCLNGGHCQNEINRFQCL-----------CPTGFS 518
PG+ G+ CE + CA C + C +CL C G
Sbjct: 518 PGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRW 577
Query: 519 GNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC 578
G C L P C+NGA C D C+C + G C + +P C
Sbjct: 578 GPNCSL------PCYCKNGASC--SPDDGICECAPGFRGTTCQRI-----CSPGFYGHRC 624
Query: 579 TVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHE-------NIN 631
S P+ V G C +G CDC GFTG C+E N
Sbjct: 625 -----SQTCPQCVH--------SSGPCHHITG---LCDCLPGFTGALCNEVCPSGRFGKN 668
Query: 632 DCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNP-------CHNGGTCRD 684
C N GTC S C C GW G+ C P CHNG C
Sbjct: 669 CAGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCS- 725
Query: 685 LVNDFYCDCKNGWKGKTCHSR------DSQCDE-ATCNNGGTCYDEGDAFKCMCPGGWEG 737
D C C GW G C R C C NG C + + +C C G+ G
Sbjct: 726 -AYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC--DHISGQCTCRTGFMG 782
Query: 738 TTCNIARNSSCLPNPCHNGGTCVVNGE----SFTCVCKEGWEGPICAQ 781
C S C C+ N + TC C GW+G C Q
Sbjct: 783 RHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
Score = 178 bits (452), Expect = 2e-44
Identities = 197/752 (26%), Positives = 265/752 (35%), Gaps = 212/752 (28%)
Query: 356 LGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT--------------------CQDLVNG 395
L F C W G N++D PN CSH + C D++N
Sbjct: 9 LSFICLLLCHWIGTASPLNLED--PNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNW 66
Query: 396 FKCV------------------------CPPQW-TGKTCQLDANECEAKPCVNAKSCKNL 430
FKC CP + +G+ C C A CV+ +
Sbjct: 67 FKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMC---VPHC-ADKCVHGR----C 118
Query: 431 IASYYCDCLPGWMGQNCDININDCLG-----------QCQNDASCRDLVNGYRCICPPGY 479
IA C C PGW G NC + C G QC+N A C + C C G+
Sbjct: 119 IAPNTCQCEPGWGGTNCS---SACDGDHWGPHCTSRCQCKNGALCNPITGA--CHCAAGF 173
Query: 480 AGDHCERDIDECA----SNPCLNGGHCQNEIN----RFQCLCPTGFSGNLCQLDIDYCEP 531
G CE D C N C CQN +C CP G++G C+ D C P
Sbjct: 174 RGWRCE---DRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE---DLCPP 227
Query: 532 N----------PCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVA 581
PCQNG C++ + C CP + G C PC
Sbjct: 228 GKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQ--------PC--------- 268
Query: 582 MASNDTPEG-VRYISSNVCGPH--GKCKSQSGGKFTCDCNKGFTGTYCHE-------NIN 631
PEG S C H G C + +G C C+ G+TG C + +
Sbjct: 269 ------PEGRFGKNCSQECQCHNGGTCDAATG---QCHCSPGYTGERCQDECPVGTYGVL 319
Query: 632 DCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN----------PCH--NG 679
E+ C NGG C S C+C G+ G CE + C + PCH N
Sbjct: 320 CAETCQCVNGGKCYH--VSGACLCEAGFAGERCEARL--CPEGLYGIKCDKRCPCHLENT 375
Query: 680 GTCRDLVNDFYCDCKNGWKGKTCHSRDS------QCDE-ATCNNGGTCYDEGDAFKCMCP 732
+C + + C CK GW G C+ S C + +C NG C + KC C
Sbjct: 376 HSCHPMSGE--CACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADC--DSVTGKCTCA 431
Query: 733 GGWEGTTCN---------IARNSSCLPNPCHNGGTC-VVNGESFTCVCKEGWEGPICAQN 782
G++G C+ I +S C C N C V+G +C CK GW G C+
Sbjct: 432 PGFKGIDCSTPCPLGTYGINCSSRC---GCKNDAVCSPVDG---SCTCKAGWHGVDCSIR 485
Query: 783 TND------CS-PHPCYNSGTC--VDGDNWYRCECAPGFAGPDCRI-------NINECQS 826
C+ C N G C +DG C CAPG+ G C + +N +
Sbjct: 486 CPSGTWGFGCNLTCQCLNGGACNTLDG----TCTCAPGWRGEKCELPCQDGTYGLNCAER 541
Query: 827 SPCAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGR--PCITMGSVIPDGAKWDDDCNT 882
C+ C C C PG SG C V GR P ++ +GA D
Sbjct: 542 CDCSHADGCHPTTG--HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGI 599
Query: 883 CQCLNG--RIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940
C+C G C ++ C P GH Q+C + H TG+ +C
Sbjct: 600 CECAPGFRGTTCQRI-CSPG----FYGHR---CSQTCPQCVHSSGPCHHITGLCDCLPGF 651
Query: 941 LQPVKTKCTSDSYYQDNCANITFTFNKEMMSP 972
+ + + NCA I N +P
Sbjct: 652 TGALCNEVCPSGRFGKNCAGICTCTNNGTCNP 683
Score = 136 bits (343), Expect = 1e-31
Identities = 116/391 (29%), Positives = 151/391 (38%), Gaps = 99/391 (25%)
Query: 185 VTCDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAICRQG------ 237
+ C +GFGCN C+ AC+ +G TC GW G +C C+ G
Sbjct: 484 IRCPSGTWGFGCNLTCQ----CLNGGACNTLDGTCTCAPGWRGEKCELP-CQDGTYGLNC 538
Query: 238 -----CSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQL 292
CS G G CRC GW G++CD +C E WG
Sbjct: 539 AERCDCSHADGCHPTTGHCRCLPGWSGVHCD----------SVC-------AEGRWGPN- 580
Query: 293 CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE------IAEHACLSDPC- 345
C C NG +CS PD C C G+ G C+ H C S C
Sbjct: 581 -------CSLPCYCKNGASCS---PDDGICECAPGFRGTTCQRICSPGFYGHRC-SQTCP 629
Query: 346 ---HNRGSCKE-TSLGFECECSPGWTGPTCSTNI------DDCSP-NNCSHGGTCQDLVN 394
H+ G C T L C+C PG+TG C+ +C+ C++ GTC +
Sbjct: 630 QCVHSSGPCHHITGL---CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDR 686
Query: 395 GFKCVCPPQWTGKTCQLDANECEAKP-CVNAKSCKN-LIASYY---CDCLPGWMG----Q 445
C C P W G C P C++ +C N S Y C C PGW G Q
Sbjct: 687 --SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQ 744
Query: 446 NCDINI--NDC--LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN------- 494
C + DC + QCQN A C D ++G +C C G+ G HCE+ +C S
Sbjct: 745 RCPLGFYGKDCALICQCQNGADC-DHISG-QCTCRTGFMGRHCEQ---KCPSGTYGYGCR 799
Query: 495 ---PCLNGGHCQNEINRFQCLCPTGFSGNLC 522
CLN C + C C G+ G C
Sbjct: 800 QICDCLNNSTCDHITG--TCYCSPGWKGARC 828
Score = 125 bits (313), Expect = 3e-28
Identities = 123/457 (26%), Positives = 162/457 (35%), Gaps = 105/457 (22%)
Query: 186 TCDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAI--------CRQ 236
TC +YG C + C ++ CD G TC G+ G +C+ C
Sbjct: 399 TCSPGFYGEACQQICSCQNG----ADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSS 454
Query: 237 GCSPKHGSCKLP--GDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCL----------- 283
C K+ + P G C C+ GW G+ C P G CN QCL
Sbjct: 455 RCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFG-CNLTCQCLNGGACNTLDGT 513
Query: 284 --CETNWGGQLCD---KDLNY---CGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
C W G+ C+ +D Y C C + C P C C G+SG +C+
Sbjct: 514 CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCH---PTTGHCRCLPGWSGVHCDS 570
Query: 336 -------AEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSH--G 386
+ L C N SC G CEC+PG+ G TC CSP H
Sbjct: 571 VCAEGRWGPNCSLPCYCKNGASCSPDD-GI-CECAPGFRGTTCQR---ICSPGFYGHRCS 625
Query: 387 GTCQDLVNGF--------KCVCPPQWTGKTC-------QLDANECEAKPCVNAKSCKNLI 431
TC V+ C C P +TG C + N C N +C +
Sbjct: 626 QTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPID 685
Query: 432 ASYYCDCLPGWMGQNCDIN----------INDCLGQCQNDASCRDLVNGYRCICPPGYAG 481
S C C PGW+G +C I+ C C N A C +G C C PG+ G
Sbjct: 686 RS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTC--NCHNGAFC-SAYDG-ECKCTPGWTG 739
Query: 482 DHCERDI------DECA-SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPC 534
+C + +CA C NG C + QC C TGF G C+ C
Sbjct: 740 LYCTQRCPLGFYGKDCALICQCQNGADCDHISG--QCTCRTGFMGRHCE--------QKC 789
Query: 535 QNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTP 571
+G Y C C C H+ C +P
Sbjct: 790 PSGT--YGYGCRQICDC---LNNSTCDHITGTCYCSP 821
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 220 bits (561), Expect = 6e-57
Identities = 181/582 (31%), Positives = 244/582 (41%), Gaps = 129/582 (22%)
Query: 345 CHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQW 404
C RG+ G C C PGW GP CS +C P NC G C D +C+C +
Sbjct: 161 CSGRGNFSTEGCG--CVCEPGWKGPNCSE--PEC-PGNCHLRGRCID----GQCICDDGF 211
Query: 405 TGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQND-AS 463
TG+ C A C + C + C N + C C G+ G +C I C C + +
Sbjct: 212 TGEDCSQLA--CPS-DCNDQGKCVNGV----CICFEGYAGADCSREI--CPVPCSEEHGT 262
Query: 464 CRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ 523
C D + C+C G+AGD C + + C +N C N G C +C+C GF+G C
Sbjct: 263 CVDGL----CVCHDGFAGDDCNKPL--CLNN-CYNRGRCVEN----ECVCDEGFTGEDCS 311
Query: 524 LDIDYCEPNPCQNGAQCYN---------------------------RASDYFCKCPEDYE 556
+ PN C + +C N R + C C E +
Sbjct: 312 ---ELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFA 368
Query: 557 GKNCS--------HLKDHCRTTPCEVIDSCTVAMASN-DTPEGVRYISSNVCGPHGKCKS 607
G +CS H + C CE D T A P G C HG+C +
Sbjct: 369 GVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNG--------CSGHGRCVN 420
Query: 608 QSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETN 667
C C++G+TG C + C N C + G C++G KC+C G++G C
Sbjct: 421 GQ-----CVCDEGYTGEDCSQ--LRC-PNDCHSRGRCVEG----KCVCEQGFKGYDC--- 465
Query: 668 INDCS-QNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDA 726
+D S N CH G C VN C C +G+ G+ C RD QC C+N G C D
Sbjct: 466 -SDMSCPNDCHQHGRC---VNGM-CVCDDGYTGEDC--RDRQCPR-DCSNRGLCVDG--- 514
Query: 727 FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDC 786
+C+C G+ G C SC PN CH G C VNG+ CVC EG+ G C +
Sbjct: 515 -QCVCEDGFTGPDC---AELSC-PNDCHGQGRC-VNGQ---CVCHEGFMGKDCKEQR--- 562
Query: 787 SPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVC 846
P C+ G CVDG +C C GF G DC + C S C CV RC+C
Sbjct: 563 CPSDCHGQGRCVDG----QCICHEGFTGLDC--GQHSCPSD-CNNLGQCVSG----RCIC 611
Query: 847 PPGHSGAKCQEVSGRPCITMGSVIPD--GAKWDDDCNTCQCL 886
G+SG C EVS + + V + WD++ + L
Sbjct: 612 NEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYL 653
Score = 206 bits (524), Expect = 1e-52
Identities = 175/596 (29%), Positives = 247/596 (41%), Gaps = 146/596 (24%)
Query: 199 FCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQ 258
FC R +F + C GW GP C+ C C + G C + G C C G+
Sbjct: 160 FCSGRGNF-----STEGCGCVCEPGWKGPNCSEPECPGNCHLR-GRC-IDGQCICDDGFT 212
Query: 259 GLYCDK------CIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCL-NGGT 311
G C + C CV+G+ C+C + G C +++ C PC GT
Sbjct: 213 GEDCSQLACPSDCNDQGKCVNGV------CICFEGYAGADCSREI--CPV--PCSEEHGT 262
Query: 312 CSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
C + C C +G++G +C + CL++ C+NRG C E EC C G+TG C
Sbjct: 263 CVDG-----LCVCHDGFAGDDCN--KPLCLNN-CYNRGRCVEN----ECVCDEGFTGEDC 310
Query: 372 STNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP-CVNAKSCKNL 430
S I PN+C G C +NG C C +TG+ C KP C +A +
Sbjct: 311 SELI---CPNDCFDRGRC---ING-TCYCEEGFTGEDC--------GKPTCPHACHTQGR 355
Query: 431 IASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490
C C G+ G +C + C C N C D RC C G+ G C +
Sbjct: 356 CEEGQCVCDEGFAGVDC--SEKRCPADCHNRGRCVD----GRCECDDGFTGADCG---EL 406
Query: 491 CASNPCLNGGHCQNEINRFQCLCPTGFSGNLC-QLDIDYCEPNPCQNGAQCYNRASDYFC 549
N C G C N QC+C G++G C QL PN C + +C C
Sbjct: 407 KCPNGCSGHGRCVNG----QCVCDEGYTGEDCSQLRC----PNDCHSRGRCVEGK----C 454
Query: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609
C + ++G +CS + SC N C HG+C +
Sbjct: 455 VCEQGFKGYDCSDM-------------SC-----------------PNDCHQHGRCVNG- 483
Query: 610 GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIN 669
C C+ G+TG C + C + C N G C+DG +C+C DG+ G
Sbjct: 484 ----MCVCDDGYTGEDCRD--RQCPRD-CSNRGLCVDG----QCVCEDGFTGP------- 525
Query: 670 DCSQ----NPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD 725
DC++ N CH G C VN C C G+ GK C ++ +C + C+ G C D
Sbjct: 526 DCAELSCPNDCHGQGRC---VNG-QCVCHEGFMGKDC--KEQRC-PSDCHGQGRCVDG-- 576
Query: 726 AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
+C+C G+ G C SC P+ C+N G CV S C+C EG+ G C++
Sbjct: 577 --QCICHEGFTGLDCG---QHSC-PSDCNNLGQCV----SGRCICNEGYSGEDCSE 622
Score = 191 bits (485), Expect = 4e-48
Identities = 157/510 (30%), Positives = 219/510 (42%), Gaps = 128/510 (25%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYACDQ-----NGNKTCMEGWMGPECNRAICRQGCSPK 241
CDD + G C++ P D C+ NG C EG+ G +C+R IC CS +
Sbjct: 207 CDDGFTGEDCSQLACPSD-------CNDQGKCVNGVCICFEGYAGADCSREICPVPCSEE 259
Query: 242 HGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVH-GICNEPWQCLCETNWGGQLCDKDL--N 298
HG+C + G C C G+ G C+K + C + G C E +C+C+ + G+ C + + N
Sbjct: 260 HGTC-VDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVEN-ECVCDEGFTGEDCSELICPN 317
Query: 299 YCGTHQPCLNGGTC----SNTGPD-----------------KYQCSCPEGYSGPNCEIAE 337
C C+N GTC TG D + QC C EG++G +C +E
Sbjct: 318 DCFDRGRCIN-GTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDC--SE 374
Query: 338 HACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFK 397
C +D CHNRG C + CEC G+TG C + PN CS G C VNG +
Sbjct: 375 KRCPAD-CHNRGRCVDG----RCECDDGFTGADCG---ELKCPNGCSGHGRC---VNG-Q 422
Query: 398 CVCPPQWTGKTC-QLDA-NECEAK-PCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC 454
CVC +TG+ C QL N+C ++ CV K C C G+ G +C + C
Sbjct: 423 CVCDEGYTGEDCSQLRCPNDCHSRGRCVEGK----------CVCEQGFKGYDC--SDMSC 470
Query: 455 LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514
C C VNG C+C GY G+ C D C N G C + QC+C
Sbjct: 471 PNDCHQHGRC---VNG-MCVCDDGYTGEDCR---DRQCPRDCSNRGLCVDG----QCVCE 519
Query: 515 TGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEV 574
GF+G C + PN C +C N C C E + GK+C + C +
Sbjct: 520 DGFTGPDC---AELSCPNDCHGQGRCVNGQ----CVCHEGFMGKDCK--EQRCPSD---- 566
Query: 575 IDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCE 634
C G+C C C++GFTG C + + C
Sbjct: 567 ------------------------CHGQGRCVDGQ-----CICHEGFTGLDCGQ--HSCP 595
Query: 635 SNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664
S+ C N G C+ G +CIC++G+ G C
Sbjct: 596 SD-CNNLGQCVSG----RCICNEGYSGEDC 620
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 219 bits (557), Expect = 2e-56
Identities = 238/887 (26%), Positives = 333/887 (37%), Gaps = 221/887 (24%)
Query: 243 GSC-KLPGD--CRCQYGWQGLYC--------DKCIPHPG-CVHGIC-NEPWQCLCETNWG 289
G C PGD C+C G++ + D+C P C G+C N CE G
Sbjct: 1084 GQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPG 1143
Query: 290 GQLCDK-----DLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY-SGPN----CEIAEHA 339
QL D+N C G C N KYQC+C GY S P+ +I E +
Sbjct: 1144 HQLSPNISACIDINECELSAHLCPNGRCVNL-IGKYQCACNPGYHSTPDRLFCVDIDECS 1202
Query: 340 CLSDPCHNRGSCKETSLGFECECSPGWT---GPTCSTNIDDCSPN-NCSHGGTCQDLVNG 395
++ C C + +EC C PG+ T+ID+C N N GG C ++
Sbjct: 1203 IMNGGCET--FCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGE 1260
Query: 396 FKCVCPPQWTG----KTCQLDANECEAKP-------CVNAKS------------------ 426
++C+C + KTC +D NEC+ P C N K
Sbjct: 1261 YRCLCYDGFMASEDMKTC-VDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTG 1319
Query: 427 -------------------CKNLIASYYCDCLPGWMGQNCDI-NINDCLG---QCQNDAS 463
C N S+ C C PGW+G ++++C C A
Sbjct: 1320 CTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHAD 1379
Query: 464 CRDLVNGYRCICPPGYAGDHCE-RDIDECASNPCLNG-GHCQNEINRFQCLCPTGF---- 517
C++ + YRC+C GY GD D+DEC+ N L G G C N ++C C GF
Sbjct: 1380 CKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSA 1439
Query: 518 SGNLCQLDIDYCE-PNPCQNGAQCYNRASDYFCKCPEDYE----GKNCSHLKD------- 565
G C+ DID C PN C G C+N + C+C YE G NC+ + +
Sbjct: 1440 DGKACE-DIDECSLPNICVFGT-CHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTC 1497
Query: 566 ---HCRTTPCEVIDSCTVAMASN-------DTPEGVRYISSNVCGPHG--KCKSQSG--- 610
+C TP I C N DT G Y+ G +G C ++ G
Sbjct: 1498 ISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGV 1557
Query: 611 GKFTCDCNKGFT-GTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG------AY 663
K +C C+ G GT CE P N + YK +C G EG
Sbjct: 1558 SKASCCCSLGKAWGT-------PCEMCPAVN-------TSEYKILCPGG-EGFRPNPITV 1602
Query: 664 CETNINDCSQNP-CHNGGTCRDLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGG 718
+I++C + P GG C + F C C G+ + C ++C+ G
Sbjct: 1603 ILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDD-VNECETPGICGPG 1661
Query: 719 TCYDEGDAFKCMCPGGW----EGTTCNIARNSSCLPNPCHNGGTC----VVNGESFTCVC 770
TCY+ + C+CP + G C R S C N + TC + N C C
Sbjct: 1662 TCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCC 1721
Query: 771 K----EGWEGPICAQ------------------------------NTNDCS--PHPCYNS 794
W P C Q + ++C P C N
Sbjct: 1722 SYNIGRAWNKP-CEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCEN- 1779
Query: 795 GTCVDGDNWYRCECAPGFAGPDCRI---NINECQSSP-CAFGATCVDEINGYRCVCPPGH 850
G C++ +RCEC GF D + +I+ECQ+ P C A C++ YRC C PG+
Sbjct: 1780 GVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGY 1839
Query: 851 ---------SGAKCQEV----SGRPCI-TMGS---VIPDGAKWDDDCNTCQCLNGRIACS 893
+CQE+ S CI T+GS + G K +DD C +N C
Sbjct: 1840 RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDIN---ECE 1896
Query: 894 KVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940
+ CG C G C I ++ C V EC S +
Sbjct: 1897 RDACGNGTCRNTIGSFNCRCNHGFILSHNNDCI-----DVDECASGN 1938
Score = 206 bits (523), Expect = 1e-52
Identities = 214/834 (25%), Positives = 323/834 (38%), Gaps = 185/834 (22%)
Query: 228 ECNRAICRQG-CSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHG---ICNE----- 278
EC R C G C GS +CRC +G+ + + CI C G +C
Sbjct: 1894 ECERDACGNGTCRNTIGSF----NCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCIN 1949
Query: 279 ---PWQCLCETNW----GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGP 331
+QC C + G+ C D+N C GTC N Y+C CP GYS
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTC-VDINECLLEPRKCAPGTCQNLD-GSYRCICPPGYSLQ 2007
Query: 332 N--CEIAEHACLSDP--CHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCS--- 384
N CE + C+ +P C G+C T F+C C G++ + D + C
Sbjct: 2008 NEKCEDIDE-CVEEPEICA-LGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKF 2065
Query: 385 HGGTCQDLV--NGFK----CVCPPQWTGKTCQL--------------------------- 411
GG C N K C + G C+L
Sbjct: 2066 EGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSA 2125
Query: 412 -DANECEAKPCVNAKSCKNLIASYYCDCLPGWM--GQNCDININDC-LGQCQNDASCRDL 467
D +EC+ C N SY C+C G++ G C ++ ++C +G + +C+++
Sbjct: 2126 VDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNEC-VDTDECSVGNPCGNGTCKNV 2184
Query: 468 VNGYRCICPPGYAGDH---CERDIDECASNPCLNGGHCQNEINRFQCLCPTGF----SGN 520
+ G+ C C G+ CE DI+ECA NP L C N ++C CP G+
Sbjct: 2185 IGGFECTCEEGFEPGPMMTCE-DINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRR 2243
Query: 521 LCQLDIDYCEPNP---CQNGAQCYNRASDYFCKCPEDY----EGKNCSHLKDHCRTTP-- 571
+C+ D D CE + +C N Y C C Y +G+ C ++ C+T P
Sbjct: 2244 MCK-DEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVD-ENECQTKPGI 2301
Query: 572 --------------CEVIDSCTVAMASN---DTPEGVRY--ISSNVCGPHGKCKSQSGGK 612
CE D T + + D EG + + N+C G K
Sbjct: 2302 CENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMC-QIGSSNRNPVTK 2360
Query: 613 FTCDCNKG-----------FTGTYCHE--------------NINDCE--SNPCRNGGTCI 645
C C+ G F GT + +I++C+ + CRN G C+
Sbjct: 2361 SECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRN-GECV 2419
Query: 646 DGVNSYKCICSDGW----EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGW---- 697
+ SY CIC G+ G C ++N+C+Q P C++ + C C G+
Sbjct: 2420 NDRGSYHCICKTGYTPDITGTSC-VDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQE 2478
Query: 698 KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLP--NPCHN 755
G++C D +C N C + F C CP G+ + N+ C N C +
Sbjct: 2479 DGRSCKDLD-ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGS 2537
Query: 756 GGTCVVNGESFTCVCKEGWE----GPICAQNTNDC-SPHPCYNSGTCVDGDNWYRCECAP 810
G C SFTC C+ G+ G C ++ ++C H C + C + YRC C
Sbjct: 2538 KGICQNTPGSFTCECQRGFSLDQTGSSC-EDVDECEGNHRCQHG--CQNIIGGYRCSCPQ 2594
Query: 811 G----FAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITM 866
G + C ++ NEC S+ GA+C + + Y+C+CP +G + ++ SG
Sbjct: 2595 GYLQHYQWNQC-VDENECLSAHICGGASCHNTLGSYKCMCP---AGFQYEQFSG------ 2644
Query: 867 GSVIPDGAKWDDDCNTCQ--CLNGRIACSKV----WCGPRPCLLHKGHSECPSG 914
G + ++C + Q C G CS CG P G C SG
Sbjct: 2645 ------GCQDINECGSAQAPCSYG---CSNTEGGYLCGCPPGYFRIGQGHCVSG 2689
Score = 191 bits (485), Expect = 4e-48
Identities = 215/857 (25%), Positives = 313/857 (36%), Gaps = 211/857 (24%)
Query: 242 HGSCKLPGDCRCQY------GWQ----GLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQ 291
H + K P C +Y GW+ G C I C G C+ P C C +
Sbjct: 50 HDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAP 109
Query: 292 LC-DKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGS 350
C + + +C C+NGG+CS+ C C +GY G +C + C S C N G
Sbjct: 110 SCGSRSIQHCNIR--CMNGGSCSDD-----HCLCQKGYIGTHC--GQPVCESG-CLNGGR 159
Query: 351 CKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKC------------ 398
C + C C+ G+TGP C + CQ ++G C
Sbjct: 160 CVAPN---RCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRA 216
Query: 399 ------VCP-----------PQWTGKTCQLDANECEAKP-CVNAKSCKNLIASYYCDCLP 440
+CP P CQ D +EC+A P +C N + S+ C C
Sbjct: 217 WGHPCEMCPAQPHPCRRGFIPNIRTGACQ-DVDECQAIPGLCQGGNCINTVGSFECKCPA 275
Query: 441 GW----MGQNCDININDCL---GQCQNDASCRDLVNGYRCICPPGY----AGDHCERDID 489
G + Q C+ +I++C G C+ C + V+ Y C CPPG+ G C D+
Sbjct: 276 GHKLNEVSQKCE-DIDECSTIPGICEG-GECTNTVSSYFCKCPPGFYTSPDGTRC-IDVR 332
Query: 490 ECASNPCLNGGHCQNE----INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS 545
L G C N+ I + QC C G + P C RA+
Sbjct: 333 PGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWS----------PGVTVAPEMCPIRAT 382
Query: 546 DYF---CKCPEDYEGK--------------------------------NCSHL---KDHC 567
+ F C P G+ +L ++
Sbjct: 383 EDFNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPP 442
Query: 568 RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627
R P V D C + VRY+ N G+C + G C+CNKGF
Sbjct: 443 RVLPVNVTDYCQL----------VRYLCQN-----GRC-IPTPGSCRCECNKGFQLDLRG 486
Query: 628 E--NINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCET---NINDCSQNP--CHNGG 680
E ++++CE NPC GG CI+ SY C C G++ T +I++C QN C+N G
Sbjct: 487 ECIDVDECEKNPCA-GGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNN-G 544
Query: 681 TCRDLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW- 735
C + F+C C G+ GK C D C N G C +E +FKC+C G+
Sbjct: 545 RCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLN-GMCINEDGSFKCICKPGFQ 603
Query: 736 ---EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVC----KEGWEGPICAQNTNDCSP 788
+G C N P C N G CV S+ C C G +G +C +
Sbjct: 604 LASDGRYCKDI-NECETPGICMN-GRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTC 661
Query: 789 HPCYNSGTCV------------------------------DGDNWYRCECAPGFAGPDCR 818
+ Y G C+ Y+ C+ G
Sbjct: 662 YGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG 721
Query: 819 ININECQSSP--CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKW 876
+INEC P C G C + Y+C+C G+ + +G+ C+ + + +
Sbjct: 722 SDINECALDPDICPNG-ICENLRGTYKCICNSGYE----VDSTGKNCVDINECVLNSLL- 775
Query: 877 DDDCNTCQCLN--GRIACSKVWCGPRPCLLHKGHSECPSGQSC--IPILDDQCFVHPCTG 932
C+ QC N G C+ C P+ + C C P ++ C P +
Sbjct: 776 ---CDNGQCRNTPGSFVCT---C-PKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSF 828
Query: 933 VGECRS-SSLQPVKTKC 948
+ EC S S+L P KT C
Sbjct: 829 ICECSSESTLDPTKTIC 845
Score = 188 bits (477), Expect = 3e-47
Identities = 221/839 (26%), Positives = 314/839 (37%), Gaps = 214/839 (25%)
Query: 264 KCIPHPGCVHGICNEPWQCLCETNWGGQLCDK----DLNYCGTHQPCLNGGTCSNTGPDK 319
+CIP PG C CE N G QL + D++ C + PC G +N G
Sbjct: 464 RCIPTPG----------SCRCECNKGFQLDLRGECIDVDECEKN-PCAGGECINNQG--S 510
Query: 320 YQCSCPEGYSGP----NCEIAEHACLSDPCHNRGSCKETSLGFECECSPGW----TGPTC 371
Y C C GY C + + N G C T F C C+ G+ G C
Sbjct: 511 YTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNC 570
Query: 372 STNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQW----TGKTCQLDANECEAKP-CVNAKS 426
++D+CS N G C + FKC+C P + G+ C+ D NECE C+N +
Sbjct: 571 E-DMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCK-DINECETPGICMNGR- 627
Query: 427 CKNLIASYYCDCLPGWM----GQNC-DININDCL------GQC---------QNDASCRD 466
C N SY C+C PG G+ C D ++ GQC +++ C
Sbjct: 628 CVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCAS 687
Query: 467 LVNG---------------YRCICPPGYAGDHCERDIDECASNP--CLNGGHCQNEINRF 509
Y+ +C G DI+ECA +P C N G C+N +
Sbjct: 688 TEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPN-GICENLRGTY 746
Query: 510 QCLCPTGF----SGNLCQLDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDY----EGKN 559
+C+C +G+ +G C +DI+ C N C NG QC N + C CP+ + + K
Sbjct: 747 KCICNSGYEVDSTGKNC-VDINECVLNSLLCDNG-QCRNTPGSFVCTCPKGFIYKPDLKT 804
Query: 560 CSHLKDHCRTTPC----------EVIDSCTVAMASNDTP----------------EGVRY 593
C + D C ++PC I C+ + T +G
Sbjct: 805 CEDI-DECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCE 863
Query: 594 ISSNVCGPHGKCKSQSGGKF-----TCD----CNKGFT---GTYCHENINDCESNP--CR 639
I+ N +C S G + C C KG++ GT C E+I++CE P C+
Sbjct: 864 ININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQC-EDIDECEVFPGVCK 922
Query: 640 NGGTCIDGVNSYKCICSDGW----EGAYC-----ETNINDCSQNPCHNGGTCRDLVNDFY 690
N G C++ S+KC C G G C ET C R ++
Sbjct: 923 N-GLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACC 981
Query: 691 CDCKNGWKGKTCHS---RDSQCDEATCNNG------------------------------ 717
C W + C R++ E C G
Sbjct: 982 CSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTH 1041
Query: 718 GTCYDEGDAFKCMCPGGW----EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEG 773
G C + +FKC C G+ E C P+ C G CV F C C EG
Sbjct: 1042 GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPGDFECKCDEG 1100
Query: 774 WEGPIC----AQNTNDCSPHPCY-NSGTCVDGDNWYRCECAPGF-AGPDCR--ININECQ 825
+E + ++C P G C + + YRCEC PG P+ I+INEC+
Sbjct: 1101 YESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECE 1160
Query: 826 SSP--CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTC 883
S C G CV+ I Y+C C PG+ PD + D + C
Sbjct: 1161 LSAHLCPNG-RCVNLIGKYQCACNPGYHST-----------------PD-RLFCVDIDEC 1201
Query: 884 QCLNGRIACSKVWC----GPRPCLLHKGHSECPSGQSCIPILDDQCFVHP--CTGVGEC 936
+NG C + +C G C G + P +SC I D+C +P C G G+C
Sbjct: 1202 SIMNG--GC-ETFCTNSEGSYECSCQPGFALMPDQRSCTDI--DECEDNPNICDG-GQC 1254
Score = 188 bits (477), Expect = 3e-47
Identities = 208/790 (26%), Positives = 306/790 (38%), Gaps = 158/790 (20%)
Query: 245 CKLPGDC---RCQYGWQGLYCDKCIPHPGCVHG--ICNEPWQCLCETNW--GGQLCDKDL 297
C+ PG C C Y G Y C P V+G C + + LC N+ Q CD +L
Sbjct: 1652 CETPGICGPGTC-YNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGEL 1710
Query: 298 NYCGTHQPCL---NGGT--------CSNTGPDKYQCSCPEG--------YSGPNCEIAEH 338
+ T + C N G C D++ C Y+G +I E
Sbjct: 1711 LFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDEC 1770
Query: 339 ACLSDPCHNRGSCKETSLGFECECSPGW---TGPTCSTNIDDCSPNN-CSHGGTCQDLVN 394
+ C N G C F CEC G+ +ID+C C C +
Sbjct: 1771 REIPGVCEN-GVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAG 1829
Query: 395 GFKCVCPPQW----TGKTCQLDANECEAKPCVNAKS-CKNLIASYYCDCLPGWM---GQN 446
++C C P + TG+ C D NEC+ P + + C + + S+YC C G+ Q
Sbjct: 1830 SYRCDCKPGYRFTSTGQ-CN-DRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQT 1887
Query: 447 CDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCER--DIDECAS---NPCLNGGH 501
++IN+C + +CR+ + + C C G+ H D+DECAS N C N G
Sbjct: 1888 MCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRN-GQ 1946
Query: 502 CQNEINRFQCLCPTGF----SGNLCQLDIDYC--EPNPCQNGAQCYNRASDYFCKCPEDY 555
C N + FQC C G+ G C +DI+ C EP C G C N Y C CP Y
Sbjct: 1947 CINTVGSFQCQCNEGYEVAPDGRTC-VDINECLLEPRKCAPGT-CQNLDGSYRCICPPGY 2004
Query: 556 EGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTC 615
+N CE ID C + PE +C G C S + G F C
Sbjct: 2005 SLQN----------EKCEDIDECV------EEPE--------ICA-LGTC-SNTEGSFKC 2038
Query: 616 DCNKGFTGTYCHENINDCESNPCR---NGGTCID----GVNSYKCICS---DGWEG--AY 663
C +GF+ + D + C GG C + +C C+ +GW
Sbjct: 2039 LCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCEL 2098
Query: 664 CETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE 723
C T ++ + C G +D D C D C C N
Sbjct: 2099 CPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE------CKEPD-VCKHGQCIN------T 2145
Query: 724 GDAFKCMCPGGW--EGTTCNIARNSSCLPNPCHNGGTC--VVNGESFTCVCKEGWE-GP- 777
+++C CP G+ G C + + + NPC N GTC V+ G F C C+EG+E GP
Sbjct: 2146 DGSYRCECPFGYILAGNEC-VDTDECSVGNPCGN-GTCKNVIGG--FECTCEEGFEPGPM 2201
Query: 778 ICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFA----------GPDCRININECQSS 827
+ ++ N+C+ +P + CV+ Y C+C G+ +C ++C
Sbjct: 2202 MTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEK 2261
Query: 828 PCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQ--- 884
C + I Y C+C PG+ + G C+ D N CQ
Sbjct: 2262 Q----MECKNLIGTYMCICGPGYQ----RRPDGEGCV--------------DENECQTKP 2299
Query: 885 --CLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQ 942
C NGR ++ G C + G + P+ C+ + CF + + SS+
Sbjct: 2300 GICENGRCLNTR---GSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRN 2356
Query: 943 PV-KTKCTSD 951
PV K++C D
Sbjct: 2357 PVTKSECCCD 2366
Score = 154 bits (388), Expect = 6e-37
Identities = 171/655 (26%), Positives = 257/655 (39%), Gaps = 133/655 (20%)
Query: 411 LDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQ----NCDININDCL--GQCQNDASC 464
+D +ECE PC + C N SY C C G+ C +I++CL G+ N+ C
Sbjct: 489 IDVDECEKNPCAGGE-CINNQGSYTCQCRAGYQSTLTRTECR-DIDECLQNGRICNNGRC 546
Query: 465 RDLVNGYRCICPPGYA----GDHCERDIDECA-SNPCLNGGHCQNEINRFQCLCPTGF-- 517
+ + C+C G+ G +CE D+DEC+ N CLNG C NE F+C+C GF
Sbjct: 547 INTDGSFHCVCNAGFHVTRDGKNCE-DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQL 604
Query: 518 --SGNLCQLDIDYCE-PNPCQNGAQCYNRASDYFCKC----PEDYEGKNC--SHLKDHC- 567
G C+ DI+ CE P C NG +C N Y C+C +G+ C +H++ C
Sbjct: 605 ASDGRYCK-DINECETPGICMNG-RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCY 662
Query: 568 ---RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT 624
+ C + S Y C P C +Q+ ++ C+ G T
Sbjct: 663 GGYKRGQC-IKPLFGAVTKSECCCASTEYAFGEPCQP---CPAQNSAEYQALCSSGPGMT 718
Query: 625 YCHENINDCESNP--CRNGGTCIDGVNSYKCICSDGWE----GAYCETNINDCSQNP--C 676
+IN+C +P C N G C + +YKCIC+ G+E G C +IN+C N C
Sbjct: 719 SAGSDINECALDPDICPN-GICENLRGTYKCICNSGYEVDSTGKNC-VDINECVLNSLLC 776
Query: 677 HNGGTCRDLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCP 732
N G CR+ F C C G+ KTC D +C+ + C N G C + +F C C
Sbjct: 777 DN-GQCRNTPGSFVCTCPKGFIYKPDLKTCEDID-ECESSPCIN-GVCKNSPGSFICECS 833
Query: 733 GG------------------WEGT---TCNIARNSSCLPNPCHNGGTCVVNGESFTCVCK 771
W+ C I N + L + C C G ++ C
Sbjct: 834 SESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQC-----CSSLGAAWGSPCT 888
Query: 772 EGWEGPIC-----------AQNTNDCSPHP--CYNSGTCVDGDNWYRCECAPGF----AG 814
PIC ++ ++C P C N G CV+ ++C+C G G
Sbjct: 889 LCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKN-GLCVNTRGSFKCQCPSGMTLDATG 947
Query: 815 PDC-RININEC----QSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSV 869
C I + C + C ++ C +C+E R +
Sbjct: 948 RICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEEL 1007
Query: 870 IP-----------DGAKWDDDCNTCQ-----CLNGRIACSKVWCGPRPCLLHKGHSECPS 913
P +G + D N C+ C +G+ C G C G +
Sbjct: 1008 CPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGK--CRNT-IGSFKCRCDSGFALDSE 1064
Query: 914 GQSCIPILDDQCFVHP-CTGVGECRSSSLQPVKTKCTSDSYYQD------NCANI 961
++C I D+C + P G G+C ++ P +C D Y+ NC +I
Sbjct: 1065 ERNCTDI--DECRISPDLCGRGQCVNT---PGDFECKCDEGYESGFMMMKNCMDI 1114
Score = 122 bits (307), Expect = 2e-27
Identities = 140/564 (24%), Positives = 210/564 (37%), Gaps = 161/564 (28%)
Query: 465 RDLVNGYRCICPPGYAGDHCER-----------DIDECASNPCLNGGHCQNEINRFQCLC 513
R L RCI PG C + D+DEC NPC GG C N + C C
Sbjct: 457 RYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCA-GGECINNQGSYTCQC 515
Query: 514 PTGFSGNLCQL---DIDYCEPNP--CQNGAQCYNRASDYFCKCPEDY----EGKNCSHLK 564
G+ L + DID C N C NG +C N + C C + +GKN
Sbjct: 516 RAGYQSTLTRTECRDIDECLQNGRICNNG-RCINTDGSFHCVCNAGFHVTRDGKN----- 569
Query: 565 DHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGF--- 621
CE +D C++ N+C +G C ++ G F C C GF
Sbjct: 570 -------CEDMDECSI---------------RNMC-LNGMCINED-GSFKCICKPGFQLA 605
Query: 622 -TGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC----SDGWEGAYCETNINDCSQNPC 676
G YC ++IN+CE+ G C++ SY+C C + G +G C ++ ++ C
Sbjct: 606 SDGRYC-KDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVC---VDTHMRSTC 661
Query: 677 HNG---GTC----RDLVNDFYCDCKN-----GWKGKTCHSRDSQCDEATCNNG------- 717
+ G G C V C C + G + C +++S +A C++G
Sbjct: 662 YGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG 721
Query: 718 ---------------GTCYDEGDAFKCMCPGGWE--GTTCNIARNSSCLPNP--CHNGGT 758
G C + +KC+C G+E T N + C+ N C N G
Sbjct: 722 SDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDN-GQ 780
Query: 759 CVVNGESFTCVCKEGW----EGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECA----- 809
C SF C C +G+ + C ++ ++C PC N G C + + CEC+
Sbjct: 781 CRNTPGSFVCTCPKGFIYKPDLKTC-EDIDECESSPCIN-GVCKNSPGSFICECSSESTL 838
Query: 810 ----------------PGFAGPDCRININE-------CQSSPCAFGATCVDEINGYRCVC 846
C ININ C S A+G+ C + +C
Sbjct: 839 DPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCT--LCQVDPIC 896
Query: 847 PPGHS---GAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCL 903
G+S G +C+++ C V C C+N R G C
Sbjct: 897 GKGYSRIKGTQCEDID--ECEVFPGV----------CKNGLCVNTR--------GSFKCQ 936
Query: 904 LHKGHSECPSGQSCIPILDDQCFV 927
G + +G+ C+ I + CF+
Sbjct: 937 CPSGMTLDATGRICLDIRLETCFL 960
Score = 86.7 bits (213), Expect = 1e-16
Identities = 87/341 (25%), Positives = 125/341 (36%), Gaps = 80/341 (23%)
Query: 651 YKCICSDGWE----GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRD 706
Y C GW+ G C I ++ C +G R + C C +G +C SR
Sbjct: 63 YNAYCCPGWKTLPGGNQCIVPI---CRHSCGDGFCSRPNM----CTCPSGQIAPSCGSRS 115
Query: 707 SQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESF 766
Q C NGG+C D+ C+C G+ GT C + C NGG CV
Sbjct: 116 IQHCNIRCMNGGSCSDD----HCLCQKGYIGTHC----GQPVCESGCLNGGRCVAPNR-- 165
Query: 767 TCVCKEGWEGPICAQN--TNDC-------------SPHPCYNSGTCVD-GDNW-YRCECA 809
C C G+ GP C ++ T C S C + C G W + CE
Sbjct: 166 -CACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMC 224
Query: 810 PGFAGPDCR------------ININECQSSP-CAFGATCVDEINGYRCVCPPGHS----G 852
P P CR +++ECQ+ P G C++ + + C CP GH
Sbjct: 225 PAQPHP-CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVS 283
Query: 853 AKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECP 912
KC+++ C T+ + C +C N S +C P G P
Sbjct: 284 QKCEDID--ECSTIPGI----------CEGGECTN---TVSSYFCKCPP-----GFYTSP 323
Query: 913 SGQSCIPILDDQCFVHPCTGVGECRSSSLQPV-KTKCTSDS 952
G CI + C+ G C + Q + K +C D+
Sbjct: 324 DGTRCIDVRPGYCYT--ALTNGRCSNQLPQSITKMQCCCDA 362
Score = 77.4 bits (189), Expect = 8e-14
Identities = 55/191 (28%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 220 CMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEP 279
C +G++G C + +C GC G C P C C YG+ G C++ C I N+
Sbjct: 136 CQKGYIGTHCGQPVCESGCL-NGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQ- 193
Query: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS---CPEGYSGPNCEIA 336
+C+ G +C K L C G C + C P +G ++
Sbjct: 194 ---MCQGQLSGIVCTKTL--CCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVD 248
Query: 337 EHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCS---TNIDDCS--PNNCSHGGTCQD 391
E + C G+C T FEC+C G S +ID+CS P C GG C +
Sbjct: 249 ECQAIPGLCQG-GNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGIC-EGGECTN 306
Query: 392 LVNGFKCVCPP 402
V+ + C CPP
Sbjct: 307 TVSSYFCKCPP 317
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 217 bits (552), Expect = 6e-56
Identities = 210/778 (26%), Positives = 310/778 (39%), Gaps = 160/778 (20%)
Query: 251 CRCQYG--WQGLYCDKCIPHPGCVH--GICNEPWQCLCETNWGGQLCDKDLNYCGTHQPC 306
C C G W G+ C+ C P P + +C G+ KD+N C
Sbjct: 939 CCCSIGAVW-GVECEAC-PDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
Query: 307 LNGGTCSNTGPDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETSLGFECEC 362
GTC NT + C+C G++ NC + +S +G+C T FECEC
Sbjct: 997 CTHGTCRNT-VGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECEC 1055
Query: 363 SPGWTG-----PTCSTNIDDCS--PNNCSHGGTCQDLVNGFKCVCPP--QWTGK-TCQLD 412
PG+ C ++D+C+ P C GGTC + +KC CPP + T K T D
Sbjct: 1056 FPGYESGFMLMKNC-MDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACED 1113
Query: 413 ANECEAKP--CVNAKSCKNLIASYYCDCLPGWMG----QNCDININDCL---GQCQNDAS 463
+EC C + + C N+I ++ C C G+ Q C ++IN+C G C D
Sbjct: 1114 IDECSLSDGLCPHGQ-CVNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQNGGC--DVH 1169
Query: 464 CRDLVNGYRCICPPGYA----GDHCERDIDECASNP-CLNGGHCQNEINRFQCLCPTGFS 518
C + YRC C GY+ G C D+DEC NP + GHC N +CLC GF
Sbjct: 1170 CINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
Query: 519 G----NLCQLDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC 572
C +D+D C+ NP C +G C N + C C Y + T C
Sbjct: 1229 ATPDMRTC-VDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRK--------GATGC 1278
Query: 573 EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT--YCHENI 630
+D C V + C H C + G F+C C G+ G CH+ +
Sbjct: 1279 SDVDECEV--------------GGHNCDSHASCLN-IPGSFSCRCLPGWVGDGFECHD-L 1322
Query: 631 NDC--ESNPCRNGGTCIDGVNSYKCICSDGW--EGAYCETNINDCSQNP--CHNGGTCRD 684
++C + + C G C++ SY+C C G+ +G +CE ++C++N C N G C +
Sbjct: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDR-DECAENVDLCDN-GQCLN 1380
Query: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNN---GGTCYDEGDAFKCMCPGGWE----G 737
+ C+C+ G+ H DE N G+C + F+C+C GG+E G
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
Query: 738 TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE----GPICAQ-NTNDC--SPHP 790
C N P C N G C+ S+ C C + +E G C +C H
Sbjct: 1441 GNCTDI-NECADPVNCIN-GVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD 1498
Query: 791 CYNSG----------------TCVDGDNW--------------YRCECAPGFAGPDCRI- 819
+SG C G W YR C G RI
Sbjct: 1499 RGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRIT 1558
Query: 820 ----NINECQSSP-CAFGATCVDEINGYRCVCPPGHSGAK----CQEVSGRPCITMGSVI 870
+I+ECQ P G CV+ ++C CPPG+ ++ C+++
Sbjct: 1559 VILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI------------ 1606
Query: 871 PDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVH 928
D+C+T + G C G C+ + + G +C+ + CF H
Sbjct: 1607 -------DECSTHSGICGPGTCYNT-LGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH 1656
Score = 215 bits (548), Expect = 2e-55
Identities = 233/846 (27%), Positives = 329/846 (38%), Gaps = 174/846 (20%)
Query: 218 KTCMEGWMGPECNR--AICRQG-CSPKHGSCKLPGDCRCQYGWQ----GLYC---DKCIP 267
K CM+ EC R +CR G C+ GS K C+C G + G C D+C
Sbjct: 1067 KNCMDV---DECARDPLLCRGGTCTNTDGSYK----CQCPPGHELTAKGTACEDIDECSL 1119
Query: 268 HPG-CVHGICNE---PWQCLCETNWGG----QLCDKDLNYCGTHQPCLNGGT---CSNTG 316
G C HG C +QC C + Q C D+N C NGG C NT
Sbjct: 1120 SDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQ----NGGCDVHCINT- 1173
Query: 317 PDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGP--- 369
Y+CSC +GYS G C + + ++G C G C C G+
Sbjct: 1174 EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDM 1233
Query: 370 -TCSTNIDDC--SPNNCSHGGTCQDLVNGFKCVCPPQWT---GKTCQLDANECEA--KPC 421
TC ++D+C +P+ C HG C++ F C C + G T D +ECE C
Sbjct: 1234 RTC-VDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNC 1291
Query: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDI-NINDCLGQ---CQNDASCRDLVNGYRCICPP 477
+ SC N+ S+ C CLPGW+G + ++++C+ Q C C ++ YRC C
Sbjct: 1292 DSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQ 1351
Query: 478 GYAGD--HCERDIDECASNPCL-NGGHCQNEINRFQCLCPTGF----SGNLCQLDIDYC- 529
G+AGD CE D DECA N L + G C N ++C C GF CQ D+D C
Sbjct: 1352 GFAGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ-DVDECA 1409
Query: 530 EPNPCQNGAQCYNRASDYFCKCPEDYE----GKNCSHLKD----------HCRTTPCEVI 575
+ N C G+ C N + C C YE G NC+ + + C TP +
Sbjct: 1410 QGNLCAFGS-CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYL 1468
Query: 576 DSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCES 635
SC N + G + C + SG + + G T C ++
Sbjct: 1469 CSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG 1528
Query: 636 NPCRNGGTC-IDGVNSYKCICSDGWEG------AYCETNINDCSQNP-CHNGGTCRDLVN 687
NPC C + Y+ +C G EG +I++C + P GG C +
Sbjct: 1529 NPCE---LCPMANTTEYRTLCPGG-EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584
Query: 688 DFYCDCKNGWKGKTCHSRDSQCDEATCNNG----GTCYDEGDAFKCMCPGGW----EGTT 739
F C+C G+ DE + ++G GTCY+ + C+CP + G
Sbjct: 1585 SFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
Query: 740 CNIARNSSCLPNPCHNGGTC----VVNGESFTCVCK----EGWEGP-------------- 777
C R S C H GTC N C C + W P
Sbjct: 1645 CMDMRKSVCFR---HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQI 1701
Query: 778 ICAQ---------------NTNDCSPHP--CYNSGTCVDGDNWYRCECAPGFAGPDCRI- 819
+C + ++C P C N G C++ +RCEC GF +
Sbjct: 1702 LCGNQAPGFLTDIHTGKPLDIDECGEIPAICAN-GICINQIGSFRCECPAGFNYNSILLA 1760
Query: 820 --NINECQS--SPCAFGATCVDEINGYRCVCPPGHS---GAKCQEVSGRPCITMGSVIPD 872
+++EC S SPC A C++ YRC C G+ G C V C + +V
Sbjct: 1761 CEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC--VGRNECREIPNVCSH 1818
Query: 873 GAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTG 932
G DC + G CL H+G C+ I D+C PC G
Sbjct: 1819 G-----DCMDTE-------------GSYMCLCHRGFQASADQTLCMDI--DECDRQPC-G 1857
Query: 933 VGECRS 938
G C++
Sbjct: 1858 NGTCKN 1863
Score = 179 bits (453), Expect = 2e-44
Identities = 228/927 (24%), Positives = 339/927 (36%), Gaps = 219/927 (23%)
Query: 212 CDQN--GNKTCMEGWMGPECNRAICRQGCSPKH-GSCKLPGDCRCQYGWQGLYCDKCIPH 268
CD+ GN TC C +C G H G C +C G Q C+
Sbjct: 1851 CDRQPCGNGTCKNIIGSYNC---LCFPGFVVTHNGDCVDFDECTTLVG-QVCRFGHCLNT 1906
Query: 269 PGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY 328
G H +C + ++ + G+ C D N C + GTC N ++C CP G+
Sbjct: 1907 AGSFHCLCQDGFELTAD----GKNC-VDTNECLSLAGTCLPGTCQNL-EGSFRCICPPGF 1960
Query: 329 SGPNCEIAEHACLSDPCHNR------GSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN 382
+ +H D C G+C + F+C C PG+ D +
Sbjct: 1961 QVQS----DHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSF 2016
Query: 383 CS---HGGTCQDLVNGF-----KCVC---PPQWTGKTCQL-------------------- 411
C G C + F +C C P + G C+L
Sbjct: 2017 CFTRFEAGKCS-VPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV 2075
Query: 412 --------DANECEAKP--CVNAKSCKNLIASYYCDCLPGWM----GQNCDININDC-LG 456
D NEC P C N C N S+ C+C G+ G NC ++ ++C +G
Sbjct: 2076 PGPDDSREDVNECAENPGVCTNGV-CVNTDGSFRCECPFGYSLDFTGINC-VDTDECSVG 2133
Query: 457 QCQNDASCRDLVNGYRCICPPGYAGD---HCERDIDECASNPCLNGGHCQNEINRFQCLC 513
+C +++ G+ C C G+ CE DIDEC+ NP L C N + C C
Sbjct: 2134 HPCGQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTEGSYLCTC 2192
Query: 514 PTGFS----GNLCQLDIDYC---EPNPCQNGAQCYNRASDYFCKCPEDY-----EGKNCS 561
P G++ G +C+ D+D C + + G +C N + C CP G+ C+
Sbjct: 2193 PAGYTLREDGAMCR-DVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT 2251
Query: 562 HLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGF 621
+ C P D C +G+C + + G F CDC++GF
Sbjct: 2252 D-DNECHAQP----DLCV----------------------NGRCVN-TAGSFRCDCDEGF 2283
Query: 622 ----TGTYCHE-----NINDCESNPCRNGGTCIDGVNSYKCICSD--GWEGAYCE----- 665
T T CH+ + CR+ + + V +C C GW G CE
Sbjct: 2284 QPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGW-GPRCELCPLP 2342
Query: 666 -------------------TNINDCSQ--NPCHNGGTCRDLVNDFYCDCKNGW----KGK 700
++++C + C + G C + + F C C+ G+
Sbjct: 2343 GTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH-GECINSLGSFRCHCQAGYTPDATAT 2401
Query: 701 TCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW----EGTTCNIARNSSCLPNPCHNG 756
TC D +C + C + +F C CP G+ +G TC + + C
Sbjct: 2402 TCLDMD-ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ-- 2458
Query: 757 GTCVVNGESFTCVCKEGW--EGPICAQNTNDCS--PHPCYNSGTCVDGDNWYRCECAPGF 812
CV +FTC C G+ C N ++CS P PC G C + +RCEC GF
Sbjct: 2459 FLCVNTVGAFTCRCPPGFTQHHQACFDN-DECSAQPGPCGAHGHCHNTPGSFRCECHQGF 2517
Query: 813 ----AGPDCRININECQS-SPCAFGATCVDEINGYRCVCPPG---HS-GAKCQEVSGRPC 863
+G C ++NEC C G C +++ GYRC CP G HS A+C V C
Sbjct: 2518 TLVSSGHGCE-DVNECDGPHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQC--VDENEC 2572
Query: 864 I----TMGS------------VIPDGAKWDDDCNTCQ----CLNGRIACS--------KV 895
T GS V P G +D CQ C R CS
Sbjct: 2573 ALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGF 2632
Query: 896 WCGPRPCLLHKGHSECPSGQSCIP---ILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDS 952
CG G C SG P D+ + EC+ + L P S
Sbjct: 2633 LCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSP--RDRPRRS 2690
Query: 953 YYQDNCANITFTFNKEMMSPGLTTEHI 979
++D+ N+ ++ +++ GL H+
Sbjct: 2691 AHRDHQVNLATLDSEALLTLGLNLSHL 2717
Score = 170 bits (431), Expect = 7e-42
Identities = 230/965 (23%), Positives = 341/965 (35%), Gaps = 312/965 (32%)
Query: 263 DKCIPHPG-CVHGICNEPW---QCLCETNWG----GQLCDKDLNYCGTHQPCLNGGTCSN 314
D+C PG C G C + QC C + ++C+ D++ C TH GTC N
Sbjct: 1565 DECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE-DIDECSTHSGICGPGTCYN 1623
Query: 315 TGPDKYQCSCPEGY----SGPNC-EIAEHACLSDPCHNRGSCKETSLGFE-----CECS- 363
T Y C CP Y G NC ++ + C H G+C + L F C CS
Sbjct: 1624 T-LGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR---HYNGTC-QNELAFNVTRKMCCCSY 1678
Query: 364 ---PGWTGP--TCST---------------------------NIDDCS--PNNCSHGGTC 389
W P C T +ID+C P C++G C
Sbjct: 1679 NIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANG-IC 1737
Query: 390 QDLVNGFKCVCPPQWTGKTCQL---DANECEAK--PCVNAKSCKNLIASYYCDCLPGW-- 442
+ + F+C CP + + L D +EC ++ PC C N+ SY C C G+
Sbjct: 1738 INQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL 1797
Query: 443 ------MGQN--------CD----------------------------ININDCLGQCQN 460
+G+N C ++I++C Q
Sbjct: 1798 SPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCG 1857
Query: 461 DASCRDLVNGYRCICPPGYAGDH---CERDIDECA------------------------- 492
+ +C++++ Y C+C PG+ H C D DEC
Sbjct: 1858 NGTCKNIIGSYNCLCFPGFVVTHNGDCV-DFDECTTLVGQVCRFGHCLNTAGSFHCLCQD 1916
Query: 493 -------------SNPCLN------GGHCQNEINRFQCLCPTGF--SGNLCQLDIDYC-- 529
+N CL+ G CQN F+C+CP GF + C +DID C
Sbjct: 1917 GFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHC-IDIDECSE 1975
Query: 530 EPNPCQNGAQCYNRASDYFCKCPED---------------------YEGKNCSHLKDHCR 568
EPN C G C N + C CP +E CS K
Sbjct: 1976 EPNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNT 2034
Query: 569 T---------------TPCEVI---------DSCTVAMAS----NDTPEGVRYISSN--V 598
T PCE+ + C + +D+ E V + N V
Sbjct: 2035 TKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGV 2094
Query: 599 CGPHGKCKSQSGGKFTCDCNKG----FTGTYCHENINDCESNPCRNGGTCIDGVNSYKCI 654
C +G C + + G F C+C G FTG C + +PC GTC + + ++C
Sbjct: 2095 C-TNGVCVN-TDGSFRCECPFGYSLDFTGINCVDTDECSVGHPC-GQGTCTNVIGGFECA 2151
Query: 655 CSDGWEGAYCET--NINDCSQNPCHNGGTCRDLVNDFYCDCKNGW----KGKTCHSRDSQ 708
C+DG+E T +I++CS NP C + + C C G+ G C D
Sbjct: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 2211
Query: 709 CD-EATCN-NGGTCYDEGDAFKCMCPGGW-----EGTTCNIARNSSCLPNPCHNGGTCVV 761
D + C+ G C + F C+CP G G C P+ C N G CV
Sbjct: 2212 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN-GRCVN 2270
Query: 762 NGESFTCVCKEGWEGPICAQNTNDCSPHPCYNS-------GTCVDGDNWYRCECAPGFA- 813
SF C C EG++ +D PC+ + R EC G
Sbjct: 2271 TAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGR 2330
Query: 814 --GPDCRI------------------------NINECQ--SSPCAFGATCVDEINGYRCV 845
GP C + +++EC+ + CA G C++ + +RC
Sbjct: 2331 GWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG-ECINSLGSFRCH 2389
Query: 846 CPPGHSG----------AKCQEVSGRPCI-----TMGSVI---PDGAKWDDDCNTC---- 883
C G++ +C +V +PC T GS + P G ++D TC
Sbjct: 2390 CQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLD 2448
Query: 884 QCLNGRIACSKVWCGPRPCLLHKG--HSECPSG-----QSCIPILDDQCFVH--PCTGVG 934
+C + + C + C+ G CP G Q+C +D+C PC G
Sbjct: 2449 ECTSRQHNCQFL------CVNTVGAFTCRCPPGFTQHHQACFD--NDECSAQPGPCGAHG 2500
Query: 935 ECRSS 939
C ++
Sbjct: 2501 HCHNT 2505
Score = 169 bits (429), Expect = 1e-41
Identities = 212/908 (23%), Positives = 325/908 (35%), Gaps = 234/908 (25%)
Query: 218 KTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRC---QYGWQGLYCDKCIPHPGCVHG 274
+ C++ + C AI + C+ +C C +G+ G C C
Sbjct: 609 RVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-GEPCQLCPAKDSA--- 664
Query: 275 ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY----SG 330
+Q LC + G +D+N C G C N Y+C C GY SG
Sbjct: 665 ----EFQALCSSGLGITTDGRDINECALDPEVCANGVCENLR-GSYRCVCNLGYEAGASG 719
Query: 331 PNCEIAEHACLSDPCHNRGSCKETSLGFECECSPG---WTGPTCSTNIDDCSPNNCSHGG 387
+C + L+ + G C+ + + C C PG W ++D+C + C G
Sbjct: 720 KDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCV-SG 778
Query: 388 TCQDLVNGFKCVCPP------------QWTGKTCQLDANE--CEAK---PCVNAKSCKNL 430
C++L + C C P T TC L E CE + ++ C L
Sbjct: 779 VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATL 838
Query: 431 IASYYCDC------------LPGWMGQNCDININDC---LGQCQNDASCRDLVNGYRCIC 475
A++ C G CD ++N+C G C N C + +RC C
Sbjct: 839 GAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPN-GRCVNTAGSFRCEC 896
Query: 476 PPGYAGDHCER--------------DIDE--------------CASNPCLNGGHCQ---- 503
P G D R D DE C S + G C+
Sbjct: 897 PEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPD 956
Query: 504 NEINRFQCLCPTG--------FSGNLCQLDIDYCE--PNPCQNGAQCYNRASDYFCKCPE 553
E F LCP G SG D++ C+ P C +G C N + C C
Sbjct: 957 PESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTVGSFHCACAG 1015
Query: 554 ----DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609
D + +NC+ + D CR IS ++CG G C + +
Sbjct: 1016 GFALDAQERNCTDI-DECR-------------------------ISPDLCG-QGTCVN-T 1047
Query: 610 GGKFTCDCNKGF-TGTYCHEN---INDCESNP--CRNGGTCIDGVNSYKCICSDGWE--- 660
G F C+C G+ +G +N +++C +P CR GGTC + SYKC C G E
Sbjct: 1048 PGSFECECFPGYESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTA 1106
Query: 661 -GAYCETNINDCSQNP--CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNG 717
G CE +I++CS + C + G C +++ F C C G++ +E NG
Sbjct: 1107 KGTACE-DIDECSLSDGLCPH-GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNG 1164
Query: 718 GT---CYDEGDAFKCMCPGGW----EGTTCNIARNSSCLPNP------------------ 752
G C + +++C C G+ +G C A C NP
Sbjct: 1165 GCDVHCINTEGSYRCSCGQGYSLMPDGRAC--ADVDECEENPRVCDQGHCTNMPGGHRCL 1222
Query: 753 CHNG-------------------------GTCVVNGESFTCVCKEGW---EGPICAQNTN 784
C++G G C SF C C+ G+ +G + +
Sbjct: 1223 CYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVD 1282
Query: 785 DC--SPHPCYNSGTCVDGDNWYRCECAPGFAGP--DCRININEC--QSSPCAFGATCVDE 838
+C H C + +C++ + C C PG+ G +C +++EC Q C+ C++
Sbjct: 1283 ECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH-DLDECVSQEHRCSPRGDCLNV 1341
Query: 839 INGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCG 898
YRC C G +G G C + A+ D C+ QCLN G
Sbjct: 1342 PGSYRCTCRQGFAG------DGFFCEDR----DECAENVDLCDNGQCLNAP--------G 1383
Query: 899 PRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQ--- 955
C G ++C + D+C G C + P +C + Y+
Sbjct: 1384 GYRCECEMGFDPTEDHRACQDV--DECAQGNLCAFGSCEN---LPGMFRCICNGGYELDR 1438
Query: 956 --DNCANI 961
NC +I
Sbjct: 1439 GGGNCTDI 1446
Score = 168 bits (426), Expect = 3e-41
Identities = 217/840 (25%), Positives = 310/840 (36%), Gaps = 208/840 (24%)
Query: 271 CVHGIC-NEPWQCLCETNWG------GQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323
C++G C P CE N G G+ D D C T PC + G C N P Y C
Sbjct: 419 CLNGRCLPTPSSYRCECNVGYTQDVRGECIDVD--EC-TSSPC-HHGDCVNI-PGTYHCR 473
Query: 324 CPEGYSGPN----CEIAEHACLSDPCHNRGSCKETSLGFECECSPGW----TGPTCSTNI 375
C G+ C + +S + G C T F+C C+ G+ G C +
Sbjct: 474 CYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDH 532
Query: 376 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWT----GKTCQLDANECEAKP-CVNAKSCKNL 430
++C+ + G C + F C+C P + G C +D +EC+ CVN C N
Sbjct: 533 NECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC-MDIDECQTPGICVNG-HCTNT 590
Query: 431 IASYYCDCLPGWM----GQNC-DINI-NDCLGQCQNDASCRDL---VNGYRCIC--PPGY 479
S+ C CL G G+ C D ++ + C G + + R V C C P
Sbjct: 591 EGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG 650
Query: 480 AGDHCE------------------------RDIDECASNP--CLNGGHCQNEINRFQCLC 513
G+ C+ RDI+ECA +P C N G C+N ++C+C
Sbjct: 651 FGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCAN-GVCENLRGSYRCVC 709
Query: 514 PTGF----SGNLCQLDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDY----EGKNCSHL 563
G+ SG C D+D C N C NG C N Y C CP + + + C +
Sbjct: 710 NLGYEAGASGKDC-TDVDECALNSLLCDNG-WCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
Query: 564 KDHCRTTPC--------EVIDSCTVAMASNDTPEGVRYISS----------------NVC 599
D C ++PC +C S P G + S N+
Sbjct: 768 -DECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQ 826
Query: 600 GP--HGKCKSQSGGKF--TCD-------CNKGF---TGTYCHENINDCESNP--CRNGGT 643
G +C + G + C+ C +GF TG C +++N+CES P C N G
Sbjct: 827 GASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTC-DDVNECESFPGVCPN-GR 884
Query: 644 CIDGVNSYKCICSDGW----EGAYC-ETNINDC----SQNPCHNGGTCRDLVNDFYCDCK 694
C++ S++C C +G G C + + C ++ C G T C C
Sbjct: 885 CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC--GVTLPGKYRMDVCCCS 942
Query: 695 NG--WKGKTCHSRDSQCDEATCNNGGTCYD-EGDAFKCMCPGGWEGTTCNI--------- 742
G W G C + C D E F +CP G + +
Sbjct: 943 IGAVW-GVECEA---------------CPDPESLEFASLCPRGLGFASRDFLSGRPFYKD 986
Query: 743 ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND-----CSPHPCYNSGTC 797
P C + GTC SF C C G+ +N D SP C GTC
Sbjct: 987 VNECKVFPGLCTH-GTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTC 1044
Query: 798 VDGDNWYRCECAPGFAG-----PDCRININECQSSP-CAFGATCVDEINGYRCVCPPGH- 850
V+ + CEC PG+ +C ++++EC P G TC + Y+C CPPGH
Sbjct: 1045 VNTPGSFECECFPGYESGFMLMKNC-MDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHE 1103
Query: 851 ---SGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKG 907
G C+++ C + P G QC+N G C H G
Sbjct: 1104 LTAKGTACEDID--ECSLSDGLCPHG----------QCVN--------VIGAFQCSCHAG 1143
Query: 908 HSECPSGQSCIPILDDQ-----CFVHPCTGVGECRSS-----SLQPVKTKCTSDSYYQDN 957
P Q C+ I + + C VH G R S SL P C ++N
Sbjct: 1144 FQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203
Score = 143 bits (360), Expect = 1e-33
Identities = 178/736 (24%), Positives = 275/736 (37%), Gaps = 137/736 (18%)
Query: 269 PGCVHG--ICNEPWQCLCETNW----GGQLCDKDL--NYCGTHQPCLNGGTCSNTGPDKY 320
PG + G +C + C W G C + CG G CS
Sbjct: 51 PGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGE-------GFCSQPN---- 99
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380
C+C +G P+C ++ + S C N G+C+ G C C G+TG C I D
Sbjct: 100 LCTCADGTLAPSCGVSRGSGCSVSCMNGGTCR----GASCLCQKGYTGTVCGQPICD--- 152
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD--C 438
C +GG C + +C C + G C+ D V + C++ + C
Sbjct: 153 RGCHNGGRC---IGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKAL 209
Query: 439 LPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCL- 497
+G+ + C Q CR R P + G C+ D+DEC + P L
Sbjct: 210 CCATVGRAWGLPCELCPAQ---PHPCR------RGFIPNIHTG-ACQ-DVDECQAVPGLC 258
Query: 498 NGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQN---GAQCYNRASDYF----CK 550
GG C N + F C CP G + + C + G +C + ++ C
Sbjct: 259 QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCC 318
Query: 551 C-----------PEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVC 599
C PE + + + C + G+ SN
Sbjct: 319 CDRGRCWAAGPVPELCPPRGSNEFQQLC-------AQRLPLLPGHPGLFPGLLGFGSNGM 371
Query: 600 G---------PHGKCKSQSGGKFTCDCNKGFTGT-YCHENINDCE--SNPCRNGGTCIDG 647
G PHG S + G + GT ++ I+ C +N C N G C+
Sbjct: 372 GPPLGPARLNPHG---SDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPT 427
Query: 648 VNSYKCICSDGWE---GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS 704
+SY+C C+ G+ C ++++C+ +PCH+ G C ++ ++C C G++
Sbjct: 428 PSSYRCECNVGYTQDVRGEC-IDVDECTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQ 485
Query: 705 RDSQCDEATCNNG----GTCYDEGDAFKCMCPGGWE----GTTCNIARNSSCLPNPCHNG 756
DE + G G C + +F+C+C G+E G C + N C N
Sbjct: 486 ACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVN- 543
Query: 757 GTCVVNGESFTCVCKEGW----EGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGF 812
G C+ SF+C+CK G+ G C +P C N G C + + +RC+C G
Sbjct: 544 GVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQCLGGL 602
Query: 813 A-GPDCRININECQSSPCAFGA----TCVDEING----YRCVCP-PGHS-GAKCQEVSGR 861
A G D R+ ++ S C +GA +C G C C P H G CQ +
Sbjct: 603 AVGTDGRVCVDTHVRSTC-YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAK 661
Query: 862 P-------CITMGSVIPDGAKWDDDCNTCQ-----CLNGRIACSKVWCGPRPCLLHKGHS 909
C + + DG D N C C NG C + G C+ + G+
Sbjct: 662 DSAEFQALCSSGLGITTDGR----DINECALDPEVCANG--VCENL-RGSYRCVCNLGYE 714
Query: 910 ECPSGQSCIPILDDQC 925
SG+ C + D+C
Sbjct: 715 AGASGKDCTDV--DEC 728
Score = 136 bits (343), Expect = 1e-31
Identities = 221/906 (24%), Positives = 304/906 (33%), Gaps = 263/906 (29%)
Query: 208 GHYACDQNGNKTCMEGWMGPECNRAICR-QGCSPKHGSCKLPGDCR-----CQYGWQGLY 261
G C Q TC +G + P C + R GCS SC G CR CQ G+ G
Sbjct: 91 GEGFCSQPNLCTCADGTLAPSCG--VSRGSGCSV---SCMNGGTCRGASCLCQKGYTGTV 145
Query: 262 CDKCIPHPGCVH-GICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320
C + I GC + G C P +C C + G C++D G GP+
Sbjct: 146 CGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYR---------TGPCFGQVGPE-- 194
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380
C +G C A C C G + G CE P P C P
Sbjct: 195 --GCQHQLTGLVCTKA--LC----CATVG----RAWGLPCELCPAQPHP-CRRGF---IP 238
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP-CVNAKSCKNLIASYYCDCL 439
N H G CQD+ +EC+A P SC N++ S++C C
Sbjct: 239 N--IHTGACQDV---------------------DECQAVPGLCQGGSCVNMVGSFHCRCP 275
Query: 440 PGWMGQNCDININDCLGQCQN--DASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCL 497
G ++D C++ +C ++ G RC G H R C C
Sbjct: 276 VGH-------RLSDSSAACEDYRAGACFSVLFGGRC---AGDLAGHYTRRQCCCDRGRCW 325
Query: 498 NGGHC-----QNEINRFQCLCP----------------TGFSGN---------------- 520
G N FQ LC GF N
Sbjct: 326 AAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGS 385
Query: 521 ------------------LCQLDIDYCE--PNPCQNGAQCYNRASDYFCKC----PEDYE 556
ID C N C NG +C S Y C+C +D
Sbjct: 386 DARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNG-RCLPTPSSYRCECNVGYTQDVR 444
Query: 557 GKNCSHLKDHCRTTPCEVIDSCTV-----------------AMASNDTPEGVRYISSNVC 599
G+ C + D C ++PC D + A D E + +S +C
Sbjct: 445 GE-CIDV-DECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECI--VSGGLC 500
Query: 600 GPHGKCKSQSGGKFTCDCNKGF----TGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC 655
G+C + + G F C CN GF G C ++ N+C ++ G C++ S+ C+C
Sbjct: 501 -HLGRCVN-TEGSFQCVCNAGFELSPDGKNCVDH-NECATSTMCVNGVCLNEDGSFSCLC 557
Query: 656 SDGW----EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKN----GWKGKTC---HS 704
G+ G YC +I++C G C + F C C G G+ C H
Sbjct: 558 KPGFLLAPGGHYC-MDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHV 616
Query: 705 RDSQC-------------------DEATCNN-----GGTCY----DEGDAFKCMCPGGWE 736
R S C E C N G C + F+ +C G
Sbjct: 617 R-STCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLG 675
Query: 737 GTTCNIARNSSCL-PNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND---CSPHPCY 792
TT N L P C N G C S+ CVC G+E ++ D C+ +
Sbjct: 676 ITTDGRDINECALDPEVCAN-GVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLL 734
Query: 793 -NSGTCVDGDNWYRCECAPGF-AGPDCRI--NINECQSSPCAFGATCVDEINGYRCVCPP 848
++G C + Y C C PGF D I +++EC SSPC G C + Y C C P
Sbjct: 735 CDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSG-VCRNLAGSYTCKCGP 793
Query: 849 GH----SGAKCQEVSGRPC-----------------ITMGSVIPDGAKWDDDCNTCQ--- 884
G SG C + + C + GA W C C+
Sbjct: 794 GSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDP 853
Query: 885 -CLNGRIACSKVWC----------GPRP---CLLHKG--HSECP-------SGQSCIPIL 921
C G + V C G P C+ G ECP SG+ C+ +
Sbjct: 854 ACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
Query: 922 DDQCFV 927
+ CF+
Sbjct: 914 LEPCFL 919
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 213 bits (543), Expect = 7e-55
Identities = 198/707 (28%), Positives = 263/707 (37%), Gaps = 158/707 (22%)
Query: 233 ICRQGCSPKHGSCKLPGDCRCQYGWQGLYCD-KCIPHPGCVHGICNEPWQC----LCETN 287
+C Q C HG C P C+C GW+G C +C P G C++P C C+
Sbjct: 104 LCAQECV--HGRCVAPNQCQCVPGWRGDDCSSECAP--GMWGPQCDKPCSCGNNSSCDPK 159
Query: 288 WGGQLCDKDLNYCGTHQPCLNGG-------TCSNTG----PDKYQCSCPEGYSGPNCEIA 336
G C L QPC G C G P C CP +GP+C+++
Sbjct: 160 SGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVS 219
Query: 337 ------EHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD------CSPN-NC 383
C S G +T G C C PGW G CS + CS C
Sbjct: 220 CSQGTSGFFCPSTHSCQNGGVFQTPQG-SCSCPPGWMGTICSLPCPEGFHGPNCSQECRC 278
Query: 384 SHGGTCQDLVNGFKCVCPPQWTGKTCQLDA------NECEAKPCVNAKSCKNLIASYYCD 437
+GG C +C C P +TG C+ + +C A+ C A + A+ C
Sbjct: 279 HNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDC-AETCDCAPDARCFPANGACL 335
Query: 438 CLPGWMGQNCDININ-------DCLGQC----QNDASCRDLVNGYRCICPPGYAGDHCER 486
C G+ G C + C C ++ SC + NG C C PG+AG HC
Sbjct: 336 CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPM-NG-ECSCLPGWAGLHCN- 392
Query: 487 DIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546
+ C + +G CQ CLC G +CQ C+ P G C +
Sbjct: 393 --ESCPQDT--HGPGCQEH-----CLC---LHGGVCQATSGLCQCAPGYTGPHCASL--- 437
Query: 547 YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGP-HGKC 605
CP D G NCS C SC A+A C P G+C
Sbjct: 438 ----CPPDTYGVNCSA---RC---------SCENAIA---------------CSPIDGEC 466
Query: 606 KSQSG---GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGA 662
+ G G + C G G C+ + C+ C + C + C C+ GW GA
Sbjct: 467 VCKEGWQRGNCSVPCPPGTWGFSCNAS---CQ---CAHEAVCSPQTGA--CTCTPGWHGA 518
Query: 663 YCETNIND-------CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ------- 708
+C+ S+ C + C D V+ C C+ GW G CH +
Sbjct: 519 HCQLPCPKGQFGEGCASRCDCDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWGVNC 576
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA-----RNSSCLPNPCHNGGTCVVNG 763
+ TC NGGTC E C+C G+ G +C + C+P C N C +
Sbjct: 577 SNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HP 632
Query: 764 ESFTCVCKEGWEGPICAQ-------NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816
+ TC C GW GP C+Q N C++ GTC D C C G+ G
Sbjct: 633 SNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG--SCICPLGWTGHH 690
Query: 817 C-------RININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
C N Q C G C E CVCPPGHSGA C+
Sbjct: 691 CLEGCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCR 735
Score = 191 bits (484), Expect = 5e-48
Identities = 202/789 (25%), Positives = 267/789 (33%), Gaps = 193/789 (24%)
Query: 217 NKTCMEGWMGPEC-------NRAICRQGCSPKHGS---CKLPGDCRCQYGWQGLYCDKCI 266
++ C W GP R + RQ H C C Y +G C
Sbjct: 52 SEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQC-----CHGFYESRGFCVPLCA 106
Query: 267 PHPGCVHGICNEPWQCLCETNWGGQLCDKDLN------YCGTHQPCLNGGTCSNTGPDKY 320
CVHG C P QC C W G C + C C N +C P
Sbjct: 107 QE--CVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCD---PKSG 161
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380
CSCP G PNC PC +PG+ GP C
Sbjct: 162 VCSCPSGLQPPNC--------LQPC-----------------TPGYYGPACQFRCQ---- 192
Query: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANE-CEAKPCVNAKSCKN----LIASYY 435
HG C C CP + TG +C + ++ C + SC+N
Sbjct: 193 ---CHGAPCDPQTGA--CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS 247
Query: 436 CDCLPGWMGQNCDININD------CLGQCQ--NDASCRDLVNGYRCICPPGYAGDHCERD 487
C C PGWMG C + + C +C+ N C D G +C C PGY GD C
Sbjct: 248 CSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLC-DRFTG-QCRCAPGYTGDRCR-- 303
Query: 488 IDECA----SNPCLNGGHCQNEINRFQ----CLCPTGFSGNLCQLDIDYCEPNPCQNGAQ 539
+EC C C + F CLC GF+G D C C +G
Sbjct: 304 -EECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTG-------DRCTDRLCPDGF- 354
Query: 540 CYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVC 599
Y + C C ++ +C + C P C + + G + +C
Sbjct: 355 -YGLSCQAPCTCDREHS-LSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQ--EHCLC 410
Query: 600 GPHGKCKSQSGGKFTCDCNKGFTGTYCHE-------NINDCESNPCRNGGTC--IDGVNS 650
G C++ SG C C G+TG +C +N C N C IDG
Sbjct: 411 LHGGVCQATSG---LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--- 464
Query: 651 YKCICSDGWEGAYCETNIN------DCSQN-PCHNGGTCRDLVNDFYCDCKNGWKGKTCH 703
+C+C +GW+ C C+ + C + C C C GW G C
Sbjct: 465 -ECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGA--CTCTPGWHGAHCQ 521
Query: 704 ----------SRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR--------- 744
S+CD C++ C + +C C GW G C+++
Sbjct: 522 LPCPKGQFGEGCASRCD---CDHSDGC--DPVHGRCQCQAGWMGARCHLSCPEGLWGVNC 576
Query: 745 NSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND------CSPHPCYNSGTCV 798
+++C C NGGTC+ E+ CVC G+ GP C ++ C P C N C
Sbjct: 577 SNTCT---CKNGGTCLP--ENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCH 631
Query: 799 DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
+ C C G+ GPDC S PC PPGH G C +
Sbjct: 632 PSNG--TCYCLAGWTGPDC--------SQPC-----------------PPGHWGENCAQT 664
Query: 859 ----SGRPCITM-GSVI-PDGAKWDDDCNTCQCLNGRIACSK-VWCGP-RPCLLHKGHSE 910
G C GS I P G C CS+ CGP C G
Sbjct: 665 CQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACV 724
Query: 911 CPSGQSCIP 919
CP G S P
Sbjct: 725 CPPGHSGAP 733
Score = 145 bits (365), Expect = 3e-34
Identities = 163/654 (24%), Positives = 228/654 (34%), Gaps = 163/654 (24%)
Query: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
+C+C PGW G CS+ +C+P G C C C +C + C
Sbjct: 119 QCQCVPGWRGDDCSS---ECAPG--MWGPQCDK-----PCSCG---NNSSCDPKSGVCSC 165
Query: 419 KPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPG 478
+ +C C PG+ G C +CQ + D G C CP
Sbjct: 166 PSGLQPPNCLQ-------PCTPGYYGPACQF-------RCQCHGAPCDPQTG-ACFCPAE 210
Query: 479 YAGDHCERDIDECAS-------NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP 531
G C+ + S + C NGG Q + C CP G+ G +C L
Sbjct: 211 RTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTP--QGSCSCPPGWMGTICSL------- 261
Query: 532 NPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVID----SCTVAMASNDT 587
PC G N + + C+C + G C CR P D C V D
Sbjct: 262 -PCPEGFHGPNCSQE--CRC---HNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDC 315
Query: 588 PEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDG 647
E C P +C +G C C GFTG C + +
Sbjct: 316 AETCD------CAPDARCFPANGA---CLCEHGFTGDRCTDRL----------------- 349
Query: 648 VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS 707
C DG+ G C+ C+ + H+ +C + + C C GW G C+
Sbjct: 350 -------CPDGFYGLSCQA---PCTCDREHSL-SCHPMNGE--CSCLPGWAGLHCNESCP 396
Query: 708 Q------CDE-ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP-------- 752
Q C E C +GG C + + C C G+ G C S C P+
Sbjct: 397 QDTHGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHCA----SLCPPDTYGVNCSAR 450
Query: 753 --CHNGGTCV-VNGESFTCVCKEGWEGPICAQNTNDCSP----HPCYNSGTC----VDGD 801
C N C ++GE CVCKEGW+ C+ C P C S C V
Sbjct: 451 CSCENAIACSPIDGE---CVCKEGWQRGNCSV---PCPPGTWGFSCNASCQCAHEAVCSP 504
Query: 802 NWYRCECAPGFAGPDCRININECQ-SSPCAFGATC-----VDEINGYRCVCPPGHSGAKC 855
C C PG+ G C++ + Q CA C D ++G RC C G GA+C
Sbjct: 505 QTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHG-RCQCQAGWMGARC 563
Query: 856 QEVSGRPCITMGSVIPDGAKWDDDC-NTCQCLNG--------RIACSKVWCGPRPCLLHK 906
P+G W +C NTC C NG C+ + GP +
Sbjct: 564 H-----------LSCPEGL-WGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPS---CQR 608
Query: 907 GHSECPSGQSCIPI-LDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCA 959
G+ C+P + F HP G C + P ++ ++ +NCA
Sbjct: 609 SCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCA 662
Score = 128 bits (321), Expect = 4e-29
Identities = 107/434 (24%), Positives = 153/434 (35%), Gaps = 109/434 (25%)
Query: 187 CDDYYYGFGCNKFCRPRDDFFGHYACD-QNGNKTCMEGWMGPECNRAI--------CRQG 237
C D +YG C C D +C NG +C+ GW G CN + C++
Sbjct: 350 CPDGFYGLSCQAPCTC--DREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEH 407
Query: 238 CSPKHGS-CK-LPGDCRCQYGWQGLYCD----------KCIPHPGCVHGICNEP--WQCL 283
C HG C+ G C+C G+ G +C C C + I P +C+
Sbjct: 408 CLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECV 467
Query: 284 CETNWGGQLCDKDLN------YCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI-- 335
C+ W C C C + CS P C+C G+ G +C++
Sbjct: 468 CKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCS---PQTGACTCTPGWHGAHCQLPC 524
Query: 336 --------------AEHACLSDPCHNRGSCKETSLGFEC--ECSPGWTGPTCSTNIDDCS 379
+H+ DP H R C+ +G C C G G CS
Sbjct: 525 PKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTC---- 580
Query: 380 PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLD------ANECEAKPCVNAKSCKNLIAS 433
C +GGTC L CVC P + G +CQ C C N C ++
Sbjct: 581 --TCKNGGTC--LPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHP--SN 634
Query: 434 YYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS 493
C CL GW G +C CPPG+ G++C +
Sbjct: 635 GTCYCLAGWTGPDCSQP------------------------CPPGHWGENCAQTCQ---- 666
Query: 494 NPCLNGGHCQNEINRFQCLCPTGFSGNLC-------QLDIDYCEPNPCQNGAQCYNRASD 546
C +GG C + C+CP G++G+ C + +P C G +C+
Sbjct: 667 --CHHGGTCHPQDG--SCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETG- 721
Query: 547 YFCKCPEDYEGKNC 560
C CP + G C
Sbjct: 722 -ACVCPPGHSGAPC 734
Score = 115 bits (288), Expect = 3e-25
Identities = 95/338 (28%), Positives = 115/338 (34%), Gaps = 108/338 (31%)
Query: 185 VTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPEC--------------N 230
V C +GF CN C+ + Q G TC GW G C +
Sbjct: 479 VPCPPGTWGFSCNASCQCAHEAV---CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCAS 535
Query: 231 RAIC--RQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNW 288
R C GC P HG C+ CQ GW G C H C G+ W
Sbjct: 536 RCDCDHSDGCDPVHGRCQ------CQAGWMGARC-----HLSCPEGL------------W 572
Query: 289 GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIA------EHACLS 342
G C C NGGTC P+ C C G+ GP+C+ + C+
Sbjct: 573 GVN--------CSNTCTCKNGGTCL---PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVP 621
Query: 343 DPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN----------CSHGGTCQDL 392
C N C ++ C C GWTGP CS C P + C HGGTC
Sbjct: 622 CKCANHSFCHPSN--GTCYCLAGWTGPDCS---QPCPPGHWGENCAQTCQCHHGGTCHP- 675
Query: 393 VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININ 452
C+CP WTG C L+ C G G NC
Sbjct: 676 -QDGSCICPLGWTGHHC-LEG------------------------CPLGTFGANCS---Q 706
Query: 453 DCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490
C QC C C+CPPG++G C I E
Sbjct: 707 PC--QCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQE 740
Score = 73.9 bits (180), Expect = 8e-13
Identities = 101/402 (25%), Positives = 135/402 (33%), Gaps = 113/402 (28%)
Query: 671 CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS------QCDE-ATCNNGGTCYDE 723
C+Q H G C V C C GW+G C S + QCD+ +C N +C +
Sbjct: 105 CAQECVH--GRC---VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPK 159
Query: 724 GDAFKCMCPGGWEGTTCNIARNSSCLPN----------PCHNGGTCVVNGESFTCVCKEG 773
C CP G + C C P CH G C + ++ C C
Sbjct: 160 SGV--CSCPSGLQPPNCL----QPCTPGYYGPACQFRCQCH-GAPC--DPQTGACFCPAE 210
Query: 774 WEGPIC----AQNTNDC---SPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININE--- 823
GP C +Q T+ S H C N G C C PG+ G C + E
Sbjct: 211 RTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQG--SCSCPPGWMGTICSLPCPEGFH 268
Query: 824 ----CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDD 879
Q C G C D G +C C PG++G +C+E P G D
Sbjct: 269 GPNCSQECRCHNGGLC-DRFTG-QCRCAPGYTGDRCRE-----------ECPVGRFGQDC 315
Query: 880 CNTCQC--------LNGRIACSKVWCGPR-----------------PCLLHKGHSECPSG 914
TC C NG C + G R PC + HS
Sbjct: 316 AETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHS----- 370
Query: 915 QSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSY---YQDNCANI-----TFTFN 966
SC P ++ +C P C S C D++ Q++C + T
Sbjct: 371 LSCHP-MNGECSCLPGWAGLHCNES--------CPQDTHGPGCQEHCLCLHGGVCQATSG 421
Query: 967 KEMMSPGLTTEHICS----ELRNLNILKNVSAEYSIYIACEP 1004
+PG T H S + +N S E + IAC P
Sbjct: 422 LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA--IACSP 461
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 213 bits (542), Expect = 9e-55
Identities = 147/495 (29%), Positives = 207/495 (41%), Gaps = 69/495 (13%)
Query: 1 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN 60
M SPR G + + L L L R +G FEL+I S G G R+
Sbjct: 1 MVSPRMSGLLSQTVILALIFLPQTRP-----AGVFELQIHSFGPGPGP-------GAPRS 48
Query: 61 PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFG---SGSTPVI----GGNTFNLKASR 113
P R C +F+VCLK S A PC+ G S PV G +L
Sbjct: 49 PCS---ARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPD 105
Query: 114 GNDRNRIVLPFSFAWPRSYTLLVEAW-DSSNDTVQPD--SIIEKASHSGMINPSRQWQTL 170
G + +PF AWP +++ ++E W + D + S++ + + + W
Sbjct: 106 G----LLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARD 161
Query: 171 KQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECN 230
Q G + R C+ G C + CRPR C G + C + EC
Sbjct: 162 IQRAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECE 215
Query: 231 RA-ICRQGCSPKHGSCKLPGDCRCQYGWQGLYC------DKC--------------IPHP 269
+CR GCSP+HG C+ PG+CRC GW G C C +P P
Sbjct: 216 APLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
Query: 270 G------CVHG-ICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTC-SNTGPD 318
G C +G C+E ++C C + G C+ C PC NGG C PD
Sbjct: 276 GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPD 334
Query: 319 K-YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD 377
Y C CP G+ G NCE C PC N G C + C C G+ GP C ++DD
Sbjct: 335 SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD 394
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
C+ C++GGTC + +C C + G+ C+ A+ C A+PC + C + C
Sbjct: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCA 454
Query: 438 CLPGWMGQNCDININ 452
C PG+MG C+ ++
Sbjct: 455 CAPGYMGARCEFPVH 469
Score = 180 bits (456), Expect = 8e-45
Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 27/231 (11%)
Query: 652 KCICSDGWEGAYCETNIND-----------------------CSQNPCHNGGTCRDLVND 688
+C C +GW G C ++ C NPC NGG+C +
Sbjct: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
Query: 689 FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY---DEGDAFKCMCPGGWEGTTCNIARN 745
F C C G+ G C C + C NGG C D A+ C CP G++G+ C R
Sbjct: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE-KRV 354
Query: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
C PC NGG C+ G + C C+ G+ GP C + +DC+ C N GTCV+G +R
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
Query: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
C CA GF G DCR + C + PCA G C +G C C PG+ GA+C+
Sbjct: 415 CSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 158 bits (400), Expect = 3e-38
Identities = 80/251 (31%), Positives = 111/251 (44%), Gaps = 32/251 (12%)
Query: 599 CGP-HGKCKSQSGGKFTCDCNKGFTGTYCHENIND-----------------------CE 634
C P HG C+ C C +G+TG C ++ C+
Sbjct: 224 CSPEHGFCEQPG----ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 635 SNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC---RDLVNDFYC 691
NPC NGG+C + S++C C G+ G CE + C+ PC NGG C D + + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN 751
C G++G C R +C C NGG C D G A +C C G+ G C + C
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD-CAGR 398
Query: 752 PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPG 811
C NGGTCV G + C C G+ G C + + C+ PC + G C + C CAPG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 812 FAGPDCRININ 822
+ G C ++
Sbjct: 459 YMGARCEFPVH 469
Score = 138 bits (348), Expect = 3e-32
Identities = 79/272 (29%), Positives = 109/272 (40%), Gaps = 31/272 (11%)
Query: 474 ICPPGYAGDH--CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY--- 528
+C G + +H CE+ EC G C ++ CL P G S +
Sbjct: 219 VCRAGCSPEHGFCEQP-GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C+ NPC NG C + C CP + G C C PC C V A D+
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLC-VGGADPDSA 336
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
+ C C GF G+ C + ++ C PCRNGG C+D
Sbjct: 337 ------------------------YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLG 372
Query: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
++ +C C G+ G CE +++DC+ C NGGTC + C C G+ G+ C R
Sbjct: 373 HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADP 432
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC 740
C C +GG CY C C G+ G C
Sbjct: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 213 bits (542), Expect = 9e-55
Identities = 147/495 (29%), Positives = 207/495 (41%), Gaps = 69/495 (13%)
Query: 1 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN 60
M SPR G + + L L L R +G FEL+I S G G R+
Sbjct: 1 MVSPRMSGLLSQTVILALIFLPQTRP-----AGVFELQIHSFGPGPGP-------GAPRS 48
Query: 61 PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFG---SGSTPVI----GGNTFNLKASR 113
P R C +F+VCLK S A PC+ G S PV G +L
Sbjct: 49 PCS---ARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPD 105
Query: 114 GNDRNRIVLPFSFAWPRSYTLLVEAW-DSSNDTVQPD--SIIEKASHSGMINPSRQWQTL 170
G + +PF AWP +++ ++E W + D + S++ + + + W
Sbjct: 106 G----LLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARD 161
Query: 171 KQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECN 230
Q G + R C+ G C + CRPR C G + C + EC
Sbjct: 162 IQRAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECE 215
Query: 231 RA-ICRQGCSPKHGSCKLPGDCRCQYGWQGLYC------DKC--------------IPHP 269
+CR GCSP+HG C+ PG+CRC GW G C C +P P
Sbjct: 216 APLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
Query: 270 G------CVHG-ICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTC-SNTGPD 318
G C +G C+E ++C C + G C+ C PC NGG C PD
Sbjct: 276 GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPD 334
Query: 319 K-YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD 377
Y C CP G+ G NCE C PC N G C + C C G+ GP C ++DD
Sbjct: 335 SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD 394
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
C+ C++GGTC + +C C + G+ C+ A+ C A+PC + C + C
Sbjct: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCA 454
Query: 438 CLPGWMGQNCDININ 452
C PG+MG C+ ++
Sbjct: 455 CAPGYMGARCEFPVH 469
Score = 180 bits (456), Expect = 8e-45
Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 27/231 (11%)
Query: 652 KCICSDGWEGAYCETNIND-----------------------CSQNPCHNGGTCRDLVND 688
+C C +GW G C ++ C NPC NGG+C +
Sbjct: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
Query: 689 FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY---DEGDAFKCMCPGGWEGTTCNIARN 745
F C C G+ G C C + C NGG C D A+ C CP G++G+ C R
Sbjct: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE-KRV 354
Query: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
C PC NGG C+ G + C C+ G+ GP C + +DC+ C N GTCV+G +R
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
Query: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
C CA GF G DCR + C + PCA G C +G C C PG+ GA+C+
Sbjct: 415 CSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 158 bits (400), Expect = 3e-38
Identities = 80/251 (31%), Positives = 111/251 (44%), Gaps = 32/251 (12%)
Query: 599 CGP-HGKCKSQSGGKFTCDCNKGFTGTYCHENIND-----------------------CE 634
C P HG C+ C C +G+TG C ++ C+
Sbjct: 224 CSPEHGFCEQPG----ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 635 SNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC---RDLVNDFYC 691
NPC NGG+C + S++C C G+ G CE + C+ PC NGG C D + + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN 751
C G++G C R +C C NGG C D G A +C C G+ G C + C
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD-CAGR 398
Query: 752 PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPG 811
C NGGTCV G + C C G+ G C + + C+ PC + G C + C CAPG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 812 FAGPDCRININ 822
+ G C ++
Sbjct: 459 YMGARCEFPVH 469
Score = 138 bits (348), Expect = 3e-32
Identities = 79/272 (29%), Positives = 109/272 (40%), Gaps = 31/272 (11%)
Query: 474 ICPPGYAGDH--CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY--- 528
+C G + +H CE+ EC G C ++ CL P G S +
Sbjct: 219 VCRAGCSPEHGFCEQP-GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
C+ NPC NG C + C CP + G C C PC C V A D+
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLC-VGGADPDSA 336
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
+ C C GF G+ C + ++ C PCRNGG C+D
Sbjct: 337 ------------------------YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLG 372
Query: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
++ +C C G+ G CE +++DC+ C NGGTC + C C G+ G+ C R
Sbjct: 373 HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADP 432
Query: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC 740
C C +GG CY C C G+ G C
Sbjct: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 212 bits (540), Expect = 2e-54
Identities = 166/601 (27%), Positives = 235/601 (39%), Gaps = 106/601 (17%)
Query: 305 PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC---KETSLGFECE 361
PC N GTC N + Y+C+CP GY G +CE++ +C S PC N G+C + F C
Sbjct: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
Query: 362 CSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANEC--EAK 419
C G+ GPTC N DDC + C++GG C D V + C CP Q+ GK C+ + C +
Sbjct: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
Query: 420 PCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQNDASCRDLVNGYRCICPPG 478
PC + C C+C+PG+ G NC N +DC +CQN A C D VN Y C+C G
Sbjct: 1053 PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEG 1112
Query: 479 YAGDHCE------RDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ--LDIDYCE 530
Y+G CE C C NG +C ++ NR C C GF G C+ L +++ +
Sbjct: 1113 YSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVD 1172
Query: 531 PNPC----------------------QNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCR 568
+ NG YN +D+ E Y+G H R
Sbjct: 1173 RDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHI--AVELYQG--------HVR 1222
Query: 569 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHE 628
+ + ++ +G + V S GG N G H
Sbjct: 1223 VSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFG-----KHY 1277
Query: 629 NINDCESNPCRNGGTCIDGVNS-----YKCICSDGWEGA----YCETNINDCSQNPCHNG 679
+N P GG +D VNS ++ + G+ G Y + D ++ G
Sbjct: 1278 TLN--SEAPLYVGGMPVD-VNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPG 1334
Query: 680 -----GTCRDLVNDFYC---DCK-NGWKGKTCHSR------------DSQCDEATCNNGG 718
CR L YC C+ N G CH D C C +G
Sbjct: 1335 VVPGCEPCRKL----YCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQ 1390
Query: 719 TCYDEGDAFKCMCPGGWEGTTCNIA-------RNSSCLPNPCHNGGTCVVNGESFTCVCK 771
+ ++ C C G+ G CN A R CL C GT + CVC
Sbjct: 1391 CVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGT-----KGAHCVCD 1445
Query: 772 EGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAF 831
G+ G +C Q ++C P + G + C+ + +CR C C
Sbjct: 1446 PGFSGELCEQE-SECRGDPVRDFHQVQRG--YAICQTTRPLSWVECR---GSCPGQGCCQ 1499
Query: 832 G 832
G
Sbjct: 1500 G 1500
Score = 186 bits (471), Expect = 2e-46
Identities = 90/271 (33%), Positives = 134/271 (49%), Gaps = 18/271 (6%)
Query: 307 LNGGTCSNTGPDKYQCSCPEGYS-GPNCEIAEHACLSDPCHNRGSCKETSLG-FECECSP 364
+ G T K++C P + C++ CLS PC N+G+C L + C C
Sbjct: 899 MEGKLLLTTPAKKFECQGPPTLAVQAKCDL----CLSSPCQNQGTCHNDPLEVYRCACPS 954
Query: 365 GWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG---FKCVCPPQWTGKTCQLDANECEAKPC 421
G+ G C ++D CS C +GGTC F C CP + G TC ++ ++C C
Sbjct: 955 GYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHAC 1014
Query: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDC---LGQCQNDASCRDLVNGYRCICPPG 478
N C + + +Y C C + G+ C+ ++ C L CQ++A C +G RC C PG
Sbjct: 1015 ANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPG 1074
Query: 479 YAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY------CEPN 532
YAGD+C + D+C + C NG C +E+N + CLC G+SG LC++ CE
Sbjct: 1075 YAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
Query: 533 PCQNGAQCYNRASDYFCKCPEDYEGKNCSHL 563
CQNGA C ++ + C+C + G C L
Sbjct: 1135 ECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
Score = 182 bits (463), Expect = 1e-45
Identities = 88/238 (36%), Positives = 121/238 (50%), Gaps = 13/238 (5%)
Query: 633 CESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVND--- 688
C S+PC+N GTC D + Y+C C G++G CE +++ CS PC NGGTC +
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
Query: 689 FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSC 748
F C C G++G TC C + C NGG C D + C CP +EG C + C
Sbjct: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL-C 1047
Query: 749 LP--NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRC 806
P NPC + CV + C C G+ G C++N +DC H C N C+D N Y C
Sbjct: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
Query: 807 ECAPGFAGPDCRININ------ECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
CA G++G C I + C+ + C GA CVD+ N C C PG G +C+++
Sbjct: 1108 LCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
Score = 176 bits (447), Expect = 9e-44
Identities = 90/231 (38%), Positives = 121/231 (52%), Gaps = 16/231 (6%)
Query: 671 CSQNPCHNGGTCR-DLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY-DEGD--A 726
C +PC N GTC D + + C C +G+KG+ C C C NGGTC+ EG+
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
Query: 727 FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDC 786
F C CP G+EG TC + C+ + C NGG CV ++TC C +EG C Q + C
Sbjct: 989 FTCSCPTGFEGPTCGV-NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLC 1047
Query: 787 SP--HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844
SP +PC + CV + RCEC PG+AG +C N ++C+ C GA C+DE+N Y C
Sbjct: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
Query: 845 VCPPGHSGAKCQ-----EVSGRPCITMGSVIPDGAKWDDDCN--TCQCLNG 888
+C G+SG C+ PC G+ +GA D N CQCL G
Sbjct: 1108 LCAEGYSGQLCEIPPHLPAPKSPC--EGTECQNGANCVDQGNRPVCQCLPG 1156
Score = 176 bits (446), Expect = 1e-43
Identities = 93/280 (33%), Positives = 122/280 (43%), Gaps = 36/280 (12%)
Query: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD-YFCKCPEDYEGKNCSHLKDH 566
+F+C P + Q D C +PCQN C+N + Y C CP Y+G++C D
Sbjct: 911 KFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967
Query: 567 CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626
C + PCE +C A D P FTC C GF G C
Sbjct: 968 CSSGPCENGGTCH-AQEGEDAP------------------------FTCSCPTGFEGPTC 1002
Query: 627 HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQ--NPCHNGGTCRD 684
N +DC + C NGG C+DGV +Y C C +EG CE ++ CS NPC + C
Sbjct: 1003 GVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVG 1062
Query: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNI-- 742
+ C+C G+ G C C + C NG C DE +++ C+C G+ G C I
Sbjct: 1063 TPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPP 1122
Query: 743 ---ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
A S C C NG CV G C C G+ GP C
Sbjct: 1123 HLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Score = 161 bits (408), Expect = 3e-39
Identities = 87/284 (30%), Positives = 125/284 (44%), Gaps = 29/284 (10%)
Query: 549 CKCPEDYEGK---NCSHLKDHCRTTPCEVIDS-CTVAMASNDTPEGVRYISSNVCGPHGK 604
C P+D EGK K C+ P + + C + ++S C G
Sbjct: 893 CAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSP-------------CQNQGT 939
Query: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCI--DGVNS-YKCICSDGWEG 661
C + + C C G+ G C +++ C S PC NGGTC +G ++ + C C G+EG
Sbjct: 940 CHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEG 999
Query: 662 AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQC--DEATCNNGGT 719
C N +DC + C NGG C D V ++ C C ++GK C C D C +
Sbjct: 1000 PTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQ 1059
Query: 720 CYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
C D +C C G+ G C+ C + C NG C+ S++C+C EG+ G +C
Sbjct: 1060 CVGTPDGPRCECMPGYAGDNCS-ENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLC 1118
Query: 780 A------QNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC 817
+ C C N CVD N C+C PGF GP+C
Sbjct: 1119 EIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Score = 150 bits (380), Expect = 5e-36
Identities = 151/610 (24%), Positives = 223/610 (36%), Gaps = 81/610 (13%)
Query: 358 FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ-DLVNGFKCVCPPQWTGKTCQLDANEC 416
FEC+ P D C + C + GTC D + ++C CP + G+ C++ + C
Sbjct: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
Query: 417 EAKPCVNAKSC---KNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYR 472
+ PC N +C + A + C C G+ G C +N +DC+ C N C D V Y
Sbjct: 969 SSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYT 1028
Query: 473 CICPPGYAGDHCERDIDECAS--NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE 530
C CP Y G CE+ +D C+ NPC + C + +C C G++G+ C + D C
Sbjct: 1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR 1088
Query: 531 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCS---HLKDHCRTTPCEVIDSCTVAMASNDT 587
+ CQNGAQC + + Y C C E Y G+ C HL +PCE +
Sbjct: 1089 DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP--APKSPCEGTE----------- 1135
Query: 588 PEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDG 647
C C Q G + C C GF G C + ++ +D
Sbjct: 1136 -----------CQNGANCVDQ-GNRPVCQCLPGFGGPECEKLLS----------VNFVDR 1173
Query: 648 VNSYKCICSDGWEGAYCETNINDCSQNP--CHNGGTCRDLVNDFYCDCKNGWKGKTCHSR 705
+ W A ++ N +NG V + + + + S
Sbjct: 1174 DTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSS 1233
Query: 706 DSQCDEATCNNGGTCYDEGDAFKCM----CPGGWEGTTCNIARNSSCLPN-PCHNGGTCV 760
E T N+G E AF M GG T N ++ + P + GG V
Sbjct: 1234 AIYSAE-TINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPV 1292
Query: 761 -VNGESFTCVCKEGWEGPICAQNTNDCSPHPCY-NSGTCVDGDNWYRCECAPGFAGPDCR 818
VN +F W Q N H C N + ++ + + PG P C
Sbjct: 1293 DVNSAAFRL-----W------QILNGTGFHGCIRNLYINNELQDFTKTQMKPGVV-PGC- 1339
Query: 819 ININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDD 878
C+ C G + G C C G G C + + PC V D
Sbjct: 1340 ---EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDA 1396
Query: 879 DCNTCQCLNG--RIACSKVWCGPRPC----LLHKGHSECPSGQSCIPILDDQCFVHPCTG 932
+CQC +G C++ PC LH GH + + + D C
Sbjct: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQASGTKGAHCVCDPGFSGELCEQ 1455
Query: 933 VGECRSSSLQ 942
ECR ++
Sbjct: 1456 ESECRGDPVR 1465
Score = 138 bits (348), Expect = 3e-32
Identities = 73/216 (33%), Positives = 97/216 (44%), Gaps = 20/216 (9%)
Query: 251 CRCQYGWQGLYC----DKCIPHPGCVHGICNE------PWQCLCETNWGGQLCDKDLNYC 300
C C G++G C D C P G C+ P+ C C T + G C + + C
Sbjct: 950 CACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDC 1009
Query: 301 GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSD--PCHNRGSCKETSLGF 358
H C NGG C + G Y C CP Y G CE C D PC + C T G
Sbjct: 1010 VDH-ACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP 1067
Query: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL------D 412
CEC PG+ G CS N DDC + C +G C D VN + C+C ++G+ C++
Sbjct: 1068 RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAP 1127
Query: 413 ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448
+ CE C N +C + C CLPG+ G C+
Sbjct: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/148 (33%), Positives = 64/148 (43%), Gaps = 25/148 (16%)
Query: 214 QNGNKTCMEGWMGPECNRAICRQGCSPKHGSCK---LPGD-CRCQYGWQGLYCDKCIPHP 269
Q+ KT M+ + P C CR+ HG C+ PG C C+ GW GL+CD+ P
Sbjct: 1324 QDFTKTQMKPGVVPGCEP--CRK-LYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP 1380
Query: 270 ----GCVHGICNE----PWQCLCETNWGGQLCDKDLNYCGT-HQPCLN----GGTCSNTG 316
CVHG C + C C+ + G LC N G +PC G C +G
Sbjct: 1381 CHGHKCVHGQCVPLDALSYSCQCQDGYSGALC----NQAGALAEPCRGLQCLHGHCQASG 1436
Query: 317 PDKYQCSCPEGYSGPNCEIAEHACLSDP 344
C C G+SG CE E C DP
Sbjct: 1437 TKGAHCVCDPGFSGELCE-QESECRGDP 1463
Score = 58.2 bits (139), Expect = 5e-08
Identities = 40/166 (24%), Positives = 64/166 (38%), Gaps = 15/166 (9%)
Query: 306 CLNGGTCSNTGPDKYQCSCPEGYSGPNCEI-AEHACLSDPCHNRGSCKETSLGFECECSP 364
CL+G N P C C G+ G +C+ A+ C C + +L + C+C
Sbjct: 1347 CLHGICQPNATPGP-MCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
Query: 365 GWTGPTCSTN---IDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPC 421
G++G C+ + C C HG G CVC P ++G+ C+ + +EC P
Sbjct: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPV 1464
Query: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDL 467
+ + A W+ +C G C C+ L
Sbjct: 1465 RDFHQVQRGYAICQTTRPLSWV---------ECRGSCPGQGCCQGL 1501
Score = 51.6 bits (122), Expect = 4e-06
Identities = 42/152 (27%), Positives = 58/152 (38%), Gaps = 32/152 (21%)
Query: 205 DFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDC---------RCQY 255
D G+Y C C + G C + + CSP C+ C C
Sbjct: 1022 DGVGNYTCQ------CPLQYEGKACEQLV--DLCSPDLNPCQHEAQCVGTPDGPRCECMP 1073
Query: 256 GWQGLYC----DKCIPHPGCVHGI-CNEP---WQCLCETNWGGQLCDKDLNYCGTHQP-- 305
G+ G C D C H C +G C + + CLC + GQLC+ + P
Sbjct: 1074 GYAGDNCSENQDDCRDHR-CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE 1132
Query: 306 ---CLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334
C NG C + G ++ C C G+ GP CE
Sbjct: 1133 GTECQNGANCVDQG-NRPVCQCLPGFGGPECE 1163
Score = 48.1 bits (113), Expect = 5e-05
Identities = 52/233 (22%), Positives = 78/233 (33%), Gaps = 46/233 (19%)
Query: 489 DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY-CEPNPCQNGAQCYNRASDY 547
+ C CL+G N C C G+ G C D C + C +G A Y
Sbjct: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
Query: 548 FCKCPEDYEGKNCSH---LKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGK 604
C+C + Y G C+ L + CR C HG
Sbjct: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQC----------------------------LHGH 1431
Query: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664
C++ C C+ GF+G C E ++C +P R+ V IC ++
Sbjct: 1432 CQASGTKGAHCVCDPGFSGELC-EQESECRGDPVRD----FHQVQRGYAICQTTRPLSWV 1486
Query: 665 ETNINDCSQNPCHNGGTCRDL---VNDFYCDCKNGWKGKTCHSRDSQCDEATC 714
E + C G C+ L F +C +G + ++C A C
Sbjct: 1487 E------CRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALC 1533
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 207 bits (526), Expect = 6e-53
Identities = 262/1008 (25%), Positives = 387/1008 (38%), Gaps = 262/1008 (25%)
Query: 208 GHYACDQNGNKTCMEGWMGP--------EC--NRAICRQG-CSPKHGSCKLPGDCRCQYG 256
G Y C C EG+ G EC N +C G C G+ + C C+ G
Sbjct: 1430 GSYRC------ACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYR----CECEMG 1479
Query: 257 W----QGLYC---DKCIPHPGCVHGICNE---PWQCLCETNW-----GGQLCDKDLNYCG 301
+ C D+C CV G CN + C+C+ + GG D D C
Sbjct: 1480 FTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDID--ECA 1537
Query: 302 THQPCLNGGTCSNTGPDKYQCSCPEGY----SGPNC---EIAEHACLSDPCHNRGSCKET 354
C+NG C NT P +Y+C+CP + +G C + P + T
Sbjct: 1538 DPINCVNG-LCVNT-PGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNT 1595
Query: 355 SLGF-----ECECSPG--WTGPTCST-----------------------------NIDDC 378
+G C CS G W P C T +ID+C
Sbjct: 1596 EIGVGVSRSSCCCSLGKAWGNP-CETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDEC 1654
Query: 379 S--PNNCSHGGTCQDLVNGFKCVCPPQW----TGKTCQLDANECEAKPCV-NAKSCKNLI 431
P C GG C + F+C CP + + C+ D +EC A P V +C N +
Sbjct: 1655 QELPGLCQ-GGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGTCYNTL 1712
Query: 432 ASYYCDCLPGWM----GQNC-DININDCLGQ-----CQNDAS-------CRDLVN----- 469
+Y C C P +M G NC D+ + C C+N+ C N
Sbjct: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772
Query: 470 -------------GYRCICP--PGYAGD-HCER--DIDECASNP--CLNGGHCQNEINRF 509
++ IC PG+ D H + DIDEC P C NG C N+I F
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSF 1831
Query: 510 QCLCPTGFSGN----LCQLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDY-------- 555
+C CPTGFS N +C+ DID C N CQ A C N Y C+C +
Sbjct: 1832 RCECPTGFSYNDLLLVCE-DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC 1890
Query: 556 -EGKNCSHLKDHCRTTPCEVIDSCTVAMASND---TPEGVRYISSNVCGPH----GKCKS 607
+ C + + C C + + N + + + + C H G CK+
Sbjct: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKN 1950
Query: 608 QSGGKFTCDCNKGFTGTYCHE--NINDCES---NPCRNGGTCIDGVNSYKCICSDGWE-- 660
+ G + C C GF T+ ++ +I++C S CRN G C + + S+KC+C++G+E
Sbjct: 1951 -TVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELT 2008
Query: 661 --GAYCETNINDCSQNP-CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRD-SQCDE-ATCN 715
G C + N+C P + GTC++L F C C G++ K+ + D ++CDE
Sbjct: 2009 PDGKNC-IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNIC 2067
Query: 716 NGGTCYDEGDAFKCMCPGGW----EGTTCNIARNSSCLPNPCHNGGTCVV----NGESFT 767
G+C + F+C+CP G+ G C R S C N G C V N
Sbjct: 2068 LFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN--FENGKCSVPKAFNTTKAK 2125
Query: 768 CVCK----EGWEGP--IC-------------------------AQNTNDC--SPHPCYNS 794
C C EGW P +C ++ N+C SP C N
Sbjct: 2126 CCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSN- 2184
Query: 795 GTCVDGDNWYRCECAPG----FAGPDCRININECQ-SSPCAFGATCVDEINGYRCVCPPG 849
G C++ D +RCEC G + G C ++ +EC +PC G TC + I + C C G
Sbjct: 2185 GQCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCGNG-TCTNVIGSFECNCNEG 2242
Query: 850 HSGA---KCQEVSG----------RPCITMGS---VIPDGAKWDDDCNTC----QCLNGR 889
C++++ R T GS P G +D C +C G
Sbjct: 2243 FEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL 2302
Query: 890 IACS------KVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQP 943
C K G C+ G + P G+ C+ +++C P G C +
Sbjct: 2303 HDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVD--ENECRTKP----GICENGRCVN 2356
Query: 944 V--KTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHIC---SELRNL 986
+ +C + +Q + + N++ + + IC S RNL
Sbjct: 2357 IIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNL 2404
Score = 202 bits (513), Expect = 2e-51
Identities = 215/803 (26%), Positives = 309/803 (38%), Gaps = 218/803 (27%)
Query: 251 CRCQYG--WQGLYCDKCIPHPGCVHGICNEPWQCLCETNWG---------GQLCDKDLNY 299
C C G W G C++C P PG + ++ LC G G+ KD+N
Sbjct: 1025 CCCAVGAAW-GTECEEC-PKPG------TKEYETLCPRGAGFANRGDVLTGRPFYKDINE 1076
Query: 300 CGTHQPCLNGGTCSNTGPDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETS 355
C G C NT ++C C G++ NC + +S G C T
Sbjct: 1077 CKAFPGMCTYGKCRNT-IGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTP 1135
Query: 356 LGFECECSPGWTG-----PTCSTNIDDCSPNNC-SHGGTCQDLVNGFKCVCPPQW----T 405
FECEC G+ C +ID+C N GGTC + F+C CP +
Sbjct: 1136 GSFECECFEGYESGFMMMKNCM-DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPS 1194
Query: 406 GKTCQLDANECEAKP--CVNAKSCKNLIASYYCDCLPGWMG----QNCDININDCL---G 456
+ C +D NEC C N K C N+I +Y C C PG+ Q C +I++C+ G
Sbjct: 1195 REDC-VDINECSLSDNLCRNGK-CVNMIGTYQCSCNPGYQATPDRQGCT-DIDECMIMNG 1251
Query: 457 QCQNDASCRDLVNGYRCICPPGYA----GDHCERDIDECASNPCL-NGGHCQNEINRFQC 511
C D C + Y C C GYA G C DIDEC +NP + +GG C N ++C
Sbjct: 1252 GC--DTQCTNSEGSYECSCSEGYALMPDGRSCA-DIDECENNPDICDGGQCTNIPGEYRC 1308
Query: 512 LCPTGFSGNLCQ---LDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH 566
LC GF ++ +D++ C+ N C G +C N + C C Y K
Sbjct: 1309 LCYDGFMASMDMKTCIDVNECDLNSNICMFG-ECENTKGSFICHCQLGYSVKK------- 1360
Query: 567 CRTTPCEVIDSCTVAMASNDTP--------------------EGVRYISSNVC--GPH-- 602
TT C +D C + + D G++ I + C G H
Sbjct: 1361 -GTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQC 1419
Query: 603 ---GKCKSQSGGKFTCDCNKGFTGT--------YCHENINDCESNPCRNG---------- 641
+C + + G + C C++GFTG C ENIN CE+ C N
Sbjct: 1420 SINAQCVN-TPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEM 1478
Query: 642 -------------------------GTCIDGVNSYKCICSDGWE----GAYCETNINDCS 672
GTC + + CIC DG+E G C T+I++C+
Sbjct: 1479 GFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECA 1537
Query: 673 QNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE--GDAFKCM 730
G C + + C+C D Q + G C D G+ +
Sbjct: 1538 DPINCVNGLCVNTPGRYECNC----------PPDFQLNP----TGVGCVDNRVGNCYLKF 1583
Query: 731 CPGGWEGTTCN------IARNSSCLP------NPCHNGGTC-VVNGESFTCVCKEGWEG- 776
P G +CN ++R+S C NPC TC VN + +C G EG
Sbjct: 1584 GPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---TCPPVNSTEYYTLC-PGGEGF 1639
Query: 777 -----PICAQNTNDCSPHP-CYNSGTCVDGDNWYRCECAPG-FAGPDCRI--NINECQSS 827
I ++ ++C P G C++ ++CEC G + D RI +I+EC +
Sbjct: 1640 RPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
Query: 828 PCAFG-ATCVDEINGYRCVCPP-------GH--------------SGAKCQ-----EVSG 860
P G TC + + Y C+CPP GH +G C+ V+
Sbjct: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
Query: 861 RPCITMGSVIPDGAKWDDDCNTC 883
R C +V G W+ C C
Sbjct: 1760 RMCCCTYNV---GKAWNKPCEPC 1779
Score = 198 bits (504), Expect = 2e-50
Identities = 205/770 (26%), Positives = 309/770 (40%), Gaps = 180/770 (23%)
Query: 233 ICRQG-CSPKHGSCKLPGDCRCQYGWQ----GLYC---DKCIPHPG-CVHGICNE---PW 280
+CR G C + GS K C C G++ G C ++C+ PG C G C +
Sbjct: 1984 VCRNGRCFNEIGSFK----CLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSF 2039
Query: 281 QCLCETNWG--GQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY----SGPNC- 333
+C+C + + C D+N C G+C+NT P +QC CP G+ +G C
Sbjct: 2040 RCICPPGYEVKSENCI-DINECDEDPNICLFGSCTNT-PGGFQCLCPPGFVLSDNGRRCF 2097
Query: 334 EIAEHACLSDPCHNRGSCKE----TSLGFECECSP----GWTGPT--------------- 370
+ + C ++ G C + +C CS GW P
Sbjct: 2098 DTRQSFCFTN--FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
Query: 371 ------------CSTNIDDC--SPNNCSHGGTCQDLVNGFKCVCPP----QWTGKTCQLD 412
++++C SP CS+G C + F+C CP +TG C +D
Sbjct: 2156 PYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCECPMGYNLDYTGVRC-VD 2213
Query: 413 ANECE-AKPCVNAKSCKNLIASYYCDCLPGWMG---QNCDININDCLGQCQNDA----SC 464
+EC PC N +C N+I S+ C+C G+ NC+ +IN+C QN C
Sbjct: 2214 TDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMNCE-DINEC---AQNPLLCAFRC 2268
Query: 465 RDLVNGYRCICPPGYAGDHCER---DIDECAS--NPCLNGGH-CQNEINRFQCLCPTGFS 518
+ Y C CP GYA ++ D+DECA + C + G C+N I F C+CP G +
Sbjct: 2269 MNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMA 2328
Query: 519 ----GNLCQLDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC 572
G C +D + C P C+NG +C N Y C+C E ++ + R C
Sbjct: 2329 RRPDGEGC-VDENECRTKPGICENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386
Query: 573 --EVIDS-CTVAMASNDTPEGVRYISSNVCGPHGK--------CKSQSGGKFTCDCNKGF 621
EV+ + C +A +S + S C G+ C ++ C G
Sbjct: 2387 FAEVLQTICQMASSSRNL-----VTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGP 2441
Query: 622 TGTYCHENINDCESNP--CRNGGTCIDGVNSYKCICSDGW----EGAYCETNINDCSQNP 675
T +I++C+ P C NG CI+ + S++C C G+ G C ++++CSQ+P
Sbjct: 2442 GYTTDGRDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSP 2499
Query: 676 CHNGGTCRDLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMC 731
C++ + C C G+ GKTC D +C N C + F C C
Sbjct: 2500 KPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD-ECQTKQHNCQFLCVNTLGGFTCKC 2558
Query: 732 PGGWEGTTCNIARNSSC--LPNPCHNGGTCVVNGESFTCVCKEGWE----GPICAQ---- 781
P G+ N+ C P+ C G C SF+C C+ G+ G C
Sbjct: 2559 PPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC 2618
Query: 782 -----------------------------------NTNDCSPHPCYNSGTCVDGDNWYRC 806
+ N+CS S +C + Y+C
Sbjct: 2619 DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKC 2678
Query: 807 ECAPGFA----GPDCRININECQSS--PCAFGATCVDEINGYRCVCPPGH 850
C GF+ C ++NEC SS PC +G C + GY C CPPG+
Sbjct: 2679 ACPSGFSFDQFSSACH-DVNECSSSKNPCNYG--CSNTEGGYLCGCPPGY 2725
Score = 193 bits (491), Expect = 7e-49
Identities = 241/887 (27%), Positives = 339/887 (38%), Gaps = 225/887 (25%)
Query: 205 DFFGHYACD-QNGNKTCMEGWMG---PECNRAICRQG-CSPKHGSCKLPGDCRCQYGWQ- 258
D G Y C NG K + M EC R C G C GS +C C G++
Sbjct: 1910 DLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSY----NCLCYPGFEL 1965
Query: 259 -----GLYCDKCIPHPG--CVHGIC-NE--PWQCLCETNW----GGQLCDKDLNYCGTHQ 304
L D+C G C +G C NE ++CLC + G+ C D N C
Sbjct: 1966 THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALP 2024
Query: 305 PCLNGGTCSNTGPDKYQCSCPEGYS--GPNCEIAEHACLSDP--CHNRGSCKETSLGFEC 360
+ GTC N ++C CP GY NC I + C DP C GSC T GF+C
Sbjct: 2025 GSCSPGTCQNL-EGSFRCICPPGYEVKSENC-IDINECDEDPNICLF-GSCTNTPGGFQC 2081
Query: 361 ECSPGWT----GPTC-STNIDDCSPNNCSHGGTCQDLVNGF-----KCVC---PPQWTGK 407
C PG+ G C T C N G C + F KC C P + G
Sbjct: 2082 LCPPGFVLSDNGRRCFDTRQSFCFTN--FENGKCS-VPKAFNTTKAKCCCSKMPGEGWGD 2138
Query: 408 TCQL----------------------------DANECEAKP--CVNAKSCKNLIASYYCD 437
C+L D NEC P C N + C N S+ C+
Sbjct: 2139 PCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGSFRCE 2197
Query: 438 CLPGW----MGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAGD---HCERDID 489
C G+ G C ++ ++C +G + +C +++ + C C G+ +CE DI+
Sbjct: 2198 CPMGYNLDYTGVRC-VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCE-DIN 2255
Query: 490 ECASNPCLNGGHCQNEINRFQCLCPTGFS----GNLCQLDIDYCEP--NPCQN-GAQCYN 542
ECA NP L C N ++C CP G++ +C+ D+D C + C++ G C N
Sbjct: 2256 ECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCK-DLDECAEGLHDCESRGMMCKN 2314
Query: 543 RASDYFCKCPEDY----EGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNV 598
+ C CP +G+ C ++ CRT P +
Sbjct: 2315 LIGTFMCICPPGMARRPDGEGCVD-ENECRTKP-------------------------GI 2348
Query: 599 CGPHGKCKSQSGGKFTCDCNKGF----TGTYCHENIND---------------------C 633
C +G+C + G + C+CN+GF +GT C +N
Sbjct: 2349 C-ENGRCVNII-GSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVT 2406
Query: 634 ESNPCRNGG-----TC----IDGVNSYKCICSDGWEGAYCETNINDCSQNP--CHNGGTC 682
+S C +GG C + G YK IC G +I++C P C N G C
Sbjct: 2407 KSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTN-GQC 2465
Query: 683 RDLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW--- 735
+ + F C CK G+ G +C D +C ++ C + +++C CP G+
Sbjct: 2466 INTMGSFRCFCKVGYTTDISGTSCIDLD-ECSQSPKPCNYICKNTEGSYQCSCPRGYVLQ 2524
Query: 736 -EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGW--EGPICAQNTNDCSPHP-- 790
+G TC + C CV FTC C G+ C N N+C P
Sbjct: 2525 EDGKTCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPGFTQHHTACIDN-NECGSQPSL 2581
Query: 791 CYNSGTCVDGDNWYRCECAPGFA----GPDCRININECQSS-PCAFGATCVDEINGYRCV 845
C G C + + CEC GF+ G +C +++EC + C G C + + GYRC
Sbjct: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCE-DVDECDGNHRCQHG--CQNILGGYRCG 2638
Query: 846 CPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLH 905
CP G+ Q C+ D N C N CG C
Sbjct: 2639 CPQGY----IQHYQWNQCV--------------DENECSNPNA--------CGSASCYNT 2672
Query: 906 KGHSE--CPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTS 950
G + CPSG S DQ F C V EC SSS P C++
Sbjct: 2673 LGSYKCACPSGFSF-----DQ-FSSACHDVNEC-SSSKNPCNYGCSN 2712
Score = 191 bits (486), Expect = 3e-48
Identities = 214/807 (26%), Positives = 326/807 (40%), Gaps = 185/807 (22%)
Query: 189 DYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPEC--NRAICRQG-CSPKHGSC 245
DY +G C C ++ H C +G ++G EC + IC G C GS
Sbjct: 734 DYGFGEPCQP-CPAKNSAEFHGLCS-SGVGITVDGRDINECALDPDICANGICENLRGSY 791
Query: 246 KLPGDCRCQYGWQ----GLYC---DKCIPHPG-CVHGIC-NEP--WQCLCETNW----GG 290
+ C C G++ G C D+C+ + C +G+C N P + C C +
Sbjct: 792 R----CNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTET 847
Query: 291 QLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS-----------CPEGYSGP-------- 331
+ C+ D+N C ++ PC+NG +N G +CS C + G
Sbjct: 848 ETCE-DINECESN-PCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
Query: 332 NCEIAEHACL--SDPCHNRGS-----CKETSLGFECECSPGWT---GPTCSTNIDDCS-- 379
CE+ + S+ C G+ C+ L + C G G TC ++++C
Sbjct: 906 RCEVNINGATLKSECCATLGAAWGSPCERCEL--DTACPRGLARIKGVTCE-DVNECEVF 962
Query: 380 PNNCSHGGTCQDLVNGFKCVCPP----QWTGKTC-QLDANECEAK----PCVNAKSCKNL 430
P C +G C + F C CP TG+ C + +C K C++ K
Sbjct: 963 PGVCPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFR 1021
Query: 431 IASYYCDCLPGWMGQNCDI---------------------------------NINDCL-- 455
+ + C W G C+ +IN+C
Sbjct: 1022 MDACCCAVGAAW-GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF 1080
Query: 456 -GQCQNDASCRDLVNGYRCICPPGYAGDHCER---DIDECASNPCLNG-GHCQNEINRFQ 510
G C CR+ + ++C C G+A D ER DIDEC +P L G G C N F+
Sbjct: 1081 PGMCTY-GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFE 1139
Query: 511 CLCPTGFSGNLCQL----DIDYCEPNP--CQNGAQCYNRASDYFCKCPEDYEGKNCSHLK 564
C C G+ + DID CE NP C+ G C N + C CP +E S +
Sbjct: 1140 CECFEGYESGFMMMKNCMDIDECERNPLLCRGGT-CVNTEGSFQCDCPLGHE---LSPSR 1195
Query: 565 DHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT 624
+ C I+ C+ +S N+C +GKC + G + C CN G+ T
Sbjct: 1196 EDCVD-----INECS--------------LSDNLCR-NGKCVNMIG-TYQCSCNPGYQAT 1234
Query: 625 YCHENINDCESNPCRNGGT---CIDGVNSYKCICSDGW----EGAYCETNINDCSQNP-- 675
+ D + NGG C + SY+C CS+G+ +G C +I++C NP
Sbjct: 1235 PDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENNPDI 1293
Query: 676 CHNGGTCRDLVNDFYCDCKNGWKG----KTCHSRDSQCD-EATCNNGGTCYDEGDAFKCM 730
C +GG C ++ ++ C C +G+ KTC + +CD + G C + +F C
Sbjct: 1294 C-DGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN-ECDLNSNICMFGECENTKGSFICH 1351
Query: 731 CPGGW---EGTT-CNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGP-ICAQNTND 785
C G+ +GTT C + C +C+ SF C C+EGW G I + ++
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDE 1411
Query: 786 CS--PHPCYNSGTCVDGDNWYRCECAPGFAG--------PDCRININECQSSPCAFGATC 835
CS H C + CV+ YRC C+ GF G +C NIN C++ C
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCEN------GQC 1465
Query: 836 VDEINGYRCVCPPGHSGA----KCQEV 858
++ YRC C G + A CQ++
Sbjct: 1466 LNVPGAYRCECEMGFTPASDSRSCQDI 1492
Score = 186 bits (471), Expect = 2e-46
Identities = 215/899 (23%), Positives = 332/899 (36%), Gaps = 209/899 (23%)
Query: 228 ECNRA--ICRQG-CSPKHGSCKLPGDCRCQYGWQGLY-------CDKC-IPHPGCVHGIC 276
EC+ + +CR G C G+ + C C G+Q D+C I + GC
Sbjct: 1203 ECSLSDNLCRNGKCVNMIGTYQ----CSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCT 1258
Query: 277 NEP--WQCLCETNWG----GQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSG 330
N ++C C + G+ C D++ C + +GG C+N P +Y+C C +G+
Sbjct: 1259 NSEGSYECSCSEGYALMPDGRSC-ADIDECENNPDICDGGQCTNI-PGEYRCLCYDGFMA 1316
Query: 331 P----------NCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWT---GPTCSTNIDD 377
C++ + C+ G C+ T F C C G++ G T T++D+
Sbjct: 1317 SMDMKTCIDVNECDLNSNICMF------GECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370
Query: 378 CS--PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQ-LDANECE--AKPCVNAKSCKNLIA 432
C +NC +C ++ FKC C W G + +D +EC C C N
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPG 1430
Query: 433 SYYCDCLPGWMGQN--------CDININDCL-GQCQND---------------------- 461
SY C C G+ G C NIN C GQC N
Sbjct: 1431 SYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ 1490
Query: 462 -------------ASCRDLVNGYRCICPPGY----AGDHCERDIDECASNPCLNGGHCQN 504
+C +L + CIC GY G +C DIDECA G C N
Sbjct: 1491 DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCT-DIDECADPINCVNGLCVN 1549
Query: 505 EINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDY-----EGKN 559
R++C CP F N + C N N + D C +
Sbjct: 1550 TPGRYECNCPPDFQLNPTGVG---CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSC 1606
Query: 560 CSHL----KDHCRTTP----CEVIDSCTVAMASNDTPEGVRYISSNVCGP-HGKCKS--- 607
C L + C T P E C P + + C G C+
Sbjct: 1607 CCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNC 1666
Query: 608 -QSGGKFTCDCNKGF---TGTYCHENINDCESNPCRNG-GTCIDGVNSYKCICSDGWEGA 662
+ G F C+C +G+ T E+I++C ++P G GTC + + +Y CIC +
Sbjct: 1667 INTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQV 1726
Query: 663 YCETNINDCSQNPC---HNGGTCRD----LVNDFYCDCK----NGWKG--KTCHSRDSQC 709
N D ++ C +NG TC + V C C W + C + +
Sbjct: 1727 NGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTAD 1786
Query: 710 DEATCNN---------------------------GGTCYDEGDAFKCMCPGGWEGT---- 738
+ C N G C ++ +F+C CP G+
Sbjct: 1787 FKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLL 1846
Query: 739 TCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE---GPICAQNTNDC--SPHPCYN 793
C S N C C+ + S+ C C G++ C + N+C P+ C +
Sbjct: 1847 VCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACV-DRNECLEIPNVC-S 1904
Query: 794 SGTCVDGDNWYRCECAPGFAGPDCR---ININECQSSPCAFGATCVDEINGYRCVCPPGH 850
G CVD Y+C C GF + ++++EC+ PC G TC + + Y C+C PG
Sbjct: 1905 HGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNG-TCKNTVGSYNCLCYPGF 1963
Query: 851 SGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTC---QCLNGRIACSKVWCGPRPCLLHKG 907
+ C+ + D+C++ C NGR G CL ++G
Sbjct: 1964 -----ELTHNNDCLDI-----------DECSSFFGQVCRNGRCFNE---IGSFKCLCNEG 2004
Query: 908 HSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVK--TKCTSDSYYQ---DNCANI 961
+ P G++CI ++C P G C + Q ++ +C Y+ +NC +I
Sbjct: 2005 YELTPDGKNCID--TNECVALP----GSCSPGTCQNLEGSFRCICPPGYEVKSENCIDI 2057
Score = 183 bits (464), Expect = 1e-45
Identities = 210/800 (26%), Positives = 307/800 (38%), Gaps = 153/800 (19%)
Query: 253 CQYGWQ----GLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLC-DKDLNYCGTHQPCL 307
C GW+ G C I C G C+ P C C + C K + C C+
Sbjct: 97 CCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVR--CM 154
Query: 308 NGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWT 367
NGGTC++ C C +GY G C + C + C N G C + C C G+T
Sbjct: 155 NGGTCADD-----HCQCQKGYIGTYC--GQPVC-ENGCQNGGRCIGPN---RCACVYGFT 203
Query: 368 GPTCSTNIDDCSPNNCSHGGTCQDLVNGFKC------------------VCP-------- 401
GP C + + CQ + G C +CP
Sbjct: 204 GPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRR 263
Query: 402 ---PQWTGKTCQLDANECEAKPCV-NAKSCKNLIASYYCDCLPGW----MGQNCDININD 453
P CQ D +EC+A P + +C N + S+ C C G Q C+ +I++
Sbjct: 264 GFIPNIRTGACQ-DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCE-DIDE 321
Query: 454 CL---GQCQNDASCRDLVNGYRCICPPGYA----GDHCERDIDECASNPCLNG---GHCQ 503
C G C+ C + V Y C+CP GY G C ID+ + C +G G C
Sbjct: 322 CSIIPGICET-GECSNTVGSYFCVCPRGYVTSTDGSRC---IDQ-RTGMCFSGLVNGRCA 376
Query: 504 NEI----NRFQCLCPTGFSGNLCQLDIDYCEPNPCQ-NGAQCYNRASDYFCKCPEDYEGK 558
E+ + QC C G + + P C G++ Y R +G
Sbjct: 377 QELPGRMTKMQCCCEPGRCWGIGTI------PEACPVRGSEEYRRLC---------MDGL 421
Query: 559 NCSHLKDHCRTTPCEVIDSCTVAMASND--TPEGVRYISSNVCGPHGKCKSQSG-GKFTC 615
+ + P + + + P G +I + G +G G G
Sbjct: 422 PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIP--IPGGNGFSPGVGGAGVGAG 479
Query: 616 DCNKGFTG-TYCHENINDCE--SNPCRNGGTCIDGVNSYKCICSDGWE---GAYCETNIN 669
TG T ++ I+ C+ +N C N G CI V+SY+C C+ G++ C +++
Sbjct: 480 GQGPIITGLTILNQTIDICKHHANLCLN-GRCIPTVSSYRCECNMGYKQDANGDC-IDVD 537
Query: 670 DCSQNPCHNGGTCRDLVNDFYCDCKNGWK----GKTCHSRDSQCDEATCNNGGTCYDEGD 725
+C+ NPC N G C + +YC C G++ + C D G C +
Sbjct: 538 ECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDG 596
Query: 726 AFKCMCPGGWEGTT--CNIARNSSC-LPNPCHNGGTCVVNGESFTCVCKEGW----EGPI 778
+F+C+C G+E TT N + C N C N G C+ SF C+CK G+ G
Sbjct: 597 SFQCICNAGFELTTDGKNCVDHDECTTTNMCLN-GMCINEDGSFKCICKPGFVLAPNGRY 655
Query: 779 CAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFA-GPDCRININECQSSPCAFG---AT 834
C +P C N G C++ + +RC+C PG A G D R+ ++ S C G
Sbjct: 656 CTDVDECQTPGICMN-GHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGV 714
Query: 835 CVDEING----YRCVC--PPGHSGAKCQEVSGRP-------CITMGSVIPDGAKWDDDCN 881
CV G C C P G CQ + C + + DG D N
Sbjct: 715 CVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR----DIN 770
Query: 882 TCQ-----CLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHP--CTGVG 934
C C NG C + G C + G+ SG++CI I D+C V+ C G
Sbjct: 771 ECALDPDICANG--ICENL-RGSYRCNCNSGYEPDASGRNCIDI--DECLVNRLLCDN-G 824
Query: 935 ECRSSSLQPVKTKCTSDSYY 954
CR++ P CT Y
Sbjct: 825 LCRNT---PGSYSCTCPPGY 841
Score = 180 bits (456), Expect = 8e-45
Identities = 211/849 (24%), Positives = 336/849 (39%), Gaps = 182/849 (21%)
Query: 228 EC--NRAICRQG-CSPKHGSCKLPGDCRCQYGWQ----GLYC---DKCIPHPGCVHGIC- 276
EC N +C+ G C GS + C C G++ G C D+C C++G+C
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQ----CICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI 633
Query: 277 NEP--WQCLCETNW----GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEG--- 327
NE ++C+C+ + G+ C D++ C T C+NG ++ G ++C CP G
Sbjct: 634 NEDGSFKCICKPGFVLAPNGRYCT-DVDECQTPGICMNGHCINSEG--SFRCDCPPGLAV 690
Query: 328 ----------------YSG----------PNCEIAEHACLSDPCHNRGS-CK----ETSL 356
Y G P C ++P + G C+ + S
Sbjct: 691 GMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSA 750
Query: 357 GFECECSPGWTGPTCSTNIDDCS--PNNCSHGGTCQDLVNGFKCVC----PPQWTGKTCQ 410
F CS G +I++C+ P+ C++ G C++L ++C C P +G+ C
Sbjct: 751 EFHGLCSSGVGITVDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNC- 808
Query: 411 LDANECEAKP--CVNAKSCKNLIASYYCDCLPGWM----GQNCDININDCLGQCQNDASC 464
+D +EC C N C+N SY C C PG++ + C+ +IN+C + +C
Sbjct: 809 IDIDECLVNRLLCDNG-LCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCVNGAC 866
Query: 465 RDLVNGYRCICPPG---------------------YAGDHCERDIDE-------CASNPC 496
R+ + + C C PG CE +I+ CA+
Sbjct: 867 RNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGA 926
Query: 497 LNGGHCQNEINRFQCLCPTGFS---GNLCQLDIDYCE--PNPCQNGAQCYNRASDYFCKC 551
G C E CP G + G C+ D++ CE P C NG +C N + C+C
Sbjct: 927 AWGSPC--ERCELDTACPRGLARIKGVTCE-DVNECEVFPGVCPNG-RCVNSKGSFHCEC 982
Query: 552 PE----DYEGKNCSHLK----------DHC-RTTPCEV-IDSCTVAMAS------NDTPE 589
PE D G+ C ++ D C P + +D+C A+ + + P+
Sbjct: 983 PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPK 1042
Query: 590 GVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNP-CRNGGTCIDGV 648
+C P G + G TG +++IN+C++ P G C + +
Sbjct: 1043 PGTKEYETLC-PRGAGFANRGDV--------LTGRPFYKDINECKAFPGMCTYGKCRNTI 1093
Query: 649 NSYKCICSDGW----EGAYCETNINDCSQNPCHNG-GTCRDLVNDFYCDCKNGWKG---- 699
S+KC C+ G+ E C T+I++C +P G G C + F C+C G++
Sbjct: 1094 GSFKCRCNSGFALDMEERNC-TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMM 1152
Query: 700 -KTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWE----GTTCNIARNSSCLPNPCH 754
K C D GGTC + +F+C CP G E C S N C
Sbjct: 1153 MKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCR 1212
Query: 755 NGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSG---TCVDGDNWYRCECAPG 811
N G CV ++ C C G++ Q D N G C + + Y C C+ G
Sbjct: 1213 N-GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEG 1271
Query: 812 FA-GPDCR--ININECQSSP-CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMG 867
+A PD R +I+EC+++P G C + YRC+C G + + + CI +
Sbjct: 1272 YALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMAS----MDMKTCIDVN 1327
Query: 868 SVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFV 927
+ D N+ C+ G +K G C G+S C + + +
Sbjct: 1328 ---------ECDLNSNICMFGECENTK---GSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
Query: 928 HPCTGVGEC 936
H C C
Sbjct: 1376 HNCDMHASC 1384
Score = 150 bits (379), Expect = 7e-36
Identities = 200/774 (25%), Positives = 295/774 (38%), Gaps = 192/774 (24%)
Query: 333 CEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCST--NIDDCSPNNCSHGGTCQ 390
C+ + CL+ G C T + CEC+ G+ ++D+C+ N C++G C
Sbjct: 498 CKHHANLCLN------GRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGD-CV 550
Query: 391 DLVNGFKCVCPPQW----TGKTCQLDANEC--EAKPCVNAKSCKNLIASYYCDCLPGWM- 443
+ + C C + T + C +D +EC C N + C N S+ C C G+
Sbjct: 551 NTPGSYYCKCHAGFQRTPTKQAC-IDIDECIQNGVLCKNGR-CVNTDGSFQCICNAGFEL 608
Query: 444 ---GQNCDININDCL--GQCQNDASCRDLVNGYRCICPPGYA----GDHCERDIDECASN 494
G+NC ++ ++C C N C + ++CIC PG+ G +C D+DEC +
Sbjct: 609 TTDGKNC-VDHDECTTTNMCLN-GMCINEDGSFKCICKPGFVLAPNGRYCT-DVDECQTP 665
Query: 495 PCLNGGHCQNEINRFQCLCP----TGFSGNLCQLDIDYCEPNPCQNGAQ---CYN----- 542
GHC N F+C CP G G +C +D + C G + C
Sbjct: 666 GICMNGHCINSEGSFRCDCPPGLAVGMDGRVC---VDTHMRSTCYGGIKKGVCVRPFPGA 722
Query: 543 -RASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTV-AMASNDTPEGVRYISSNVCG 600
S+ C P+ G+ C PC +S + S+ V N C
Sbjct: 723 VTKSECCCANPDYGFGEPCQ---------PCPAKNSAEFHGLCSSGVGITVDGRDINECA 773
Query: 601 ------PHGKCKSQSGGKFTCDCNKGF----TGTYCHENINDCESNP--CRNGGTCIDGV 648
+G C++ G + C+CN G+ +G C + I++C N C N G C +
Sbjct: 774 LDPDICANGICENLR-GSYRCNCNSGYEPDASGRNCID-IDECLVNRLLCDN-GLCRNTP 830
Query: 649 NSYKCICSDGW----EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWK----GK 700
SY C C G+ E CE +IN+C NPC N G CR+ + F C+C G K G
Sbjct: 831 GSYSCTCPPGYVFRTETETCE-DINECESNPCVN-GACRNNLGSFNCECSPGSKLSSTGL 888
Query: 701 TC----------HSRDSQCDEATCNNGGT-----CYDEGDAF-----KC----MCPGGW- 735
C + +DS+C+ NG T C G A+ +C CP G
Sbjct: 889 ICIDSLKGTCWLNIQDSRCEVNI--NGATLKSECCATLGAAWGSPCERCELDTACPRGLA 946
Query: 736 --EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEG----WEGPICAQ-------- 781
+G TC P C N G CV + SF C C EG G +C
Sbjct: 947 RIKGVTCEDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYL 1005
Query: 782 --NTNDCSPHPC-----YNSGTCVDGDNW-YRCECAP---------------GFA----- 813
+ ++C HP ++ C G W CE P GFA
Sbjct: 1006 KWDEDECI-HPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDV 1064
Query: 814 --GPDCRININECQSSP--CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGS- 868
G +INEC++ P C +G C + I ++C C G + ++ R C +
Sbjct: 1065 LTGRPFYKDINECKAFPGMCTYG-KCRNTIGSFKCRCNSGFA----LDMEERNCTDIDEC 1119
Query: 869 -VIPDGAKWDDDCNT-----CQCLNGRIA-------CSKV-WCGPRPCLLHKG------- 907
+ PD NT C+C G + C + C P L G
Sbjct: 1120 RISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEG 1179
Query: 908 --HSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTS-DSYYQDNC 958
+CP G P +D C + EC S KC + YQ +C
Sbjct: 1180 SFQCDCPLGHELSPSRED------CVDINECSLSDNLCRNGKCVNMIGTYQCSC 1227
Score = 147 bits (372), Expect = 5e-35
Identities = 170/662 (25%), Positives = 242/662 (36%), Gaps = 145/662 (21%)
Query: 298 NYCGT--HQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETS 355
N CG+ H C G T P QC P I ++C G C +
Sbjct: 87 NVCGSRFHSYCCPGW---KTLPGGNQCIVP---------ICRNSC------GDGFCSRPN 128
Query: 356 LGFECECSPGWTGPTC-STNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDAN 414
+ C CS G TC S +I CS C +GGTC D C C + G C
Sbjct: 129 M---CTCSSGQISSTCGSKSIQQCSVR-CMNGGTCAD----DHCQCQKGYIGTYCGQPV- 179
Query: 415 ECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD-----------ININDCLGQ-----C 458
CE C N C I C C+ G+ G C+ +N C GQ C
Sbjct: 180 -CE-NGCQNGGRC---IGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVC 234
Query: 459 QNDASCRDLVN--GYRC-ICP-----------PGYAGDHCERDIDECASNPCL-NGGHCQ 503
C + G+ C +CP P C+ D+DEC + P + GG+C
Sbjct: 235 TKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQ-DVDECQAIPGICQGGNCI 293
Query: 504 NEINRFQCLCPTGF----SGNLCQLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDY-- 555
N + F+C CP G + C+ DID C P C+ G +C N YFC CP Y
Sbjct: 294 NTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETG-ECSNTVGSYFCVCPRGYVT 351
Query: 556 --EGKNC-------------------------SHLKDHCRTTPCEVIDSCTVAMASNDTP 588
+G C + ++ C C I + A +
Sbjct: 352 STDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSE 411
Query: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
E R + P G +G + GF + N P G I G
Sbjct: 412 EYRRLCMDGL--PMGGIPGSAGSRPGGTGGNGFA-----PSGNGNGYGPGGTGFIPIPGG 464
Query: 649 NSYKCICSDGWEGAYCE-------TNINDCSQNPCHNGGTCRD-----LVNDFYCDCKNG 696
N + GA + T +N H+ C + V+ + C+C G
Sbjct: 465 NGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMG 524
Query: 697 WK---GKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA--RNSSCLPN 751
+K C D +C C N G C + ++ C C G++ T A C+ N
Sbjct: 525 YKQDANGDCIDVD-ECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQN 582
Query: 752 P--CHNGGTCVVNGESFTCVCKEGWE----GPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
C N G CV SF C+C G+E G C + + + C N G C++ D ++
Sbjct: 583 GVLCKN-GRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLN-GMCINEDGSFK 640
Query: 806 CECAPGFA-GPDCR--ININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRP 862
C C PGF P+ R +++ECQ+ C++ +RC CPPG + + GR
Sbjct: 641 CICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVG----MDGRV 696
Query: 863 CI 864
C+
Sbjct: 697 CV 698
Score = 89.7 bits (221), Expect = 1e-17
Identities = 88/329 (26%), Positives = 120/329 (36%), Gaps = 86/329 (26%)
Query: 639 RNGGTCIDGVNSYKCICSDGWE----GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCK 694
R C +SY C GW+ G C I +N C +G R + C C
Sbjct: 84 RGPNVCGSRFHSY---CCPGWKTLPGGNQCIVPI---CRNSCGDGFCSRPNM----CTCS 133
Query: 695 NGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCH 754
+G TC S+ Q C NGGTC D+ C C G+ GT C N C
Sbjct: 134 SGQISSTCGSKSIQQCSVRCMNGGTCADD----HCQCQKGYIGTYC----GQPVCENGCQ 185
Query: 755 NGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCY---NSGTC-------------- 797
NGG C+ C C G+ GP C + D PC+ N+ C
Sbjct: 186 NGGRCIGPNR---CACVYGFTGPQCER---DYRTGPCFTQVNNQMCQGQLTGIVCTKTLC 239
Query: 798 --VDGDNW-YRCECAPGFAGPDCR------------ININECQSSP-CAFGATCVDEING 841
G W + CE P P CR +++ECQ+ P G C++ +
Sbjct: 240 CATIGRAWGHPCEMCPAQPQP-CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS 298
Query: 842 YRCVCPPGHSGA----KCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWC 897
+ C CP GH + KC+++ C S+IP C T +C N
Sbjct: 299 FECRCPAGHKQSETTQKCEDID--EC----SIIP------GICETGECSN--------TV 338
Query: 898 GPRPCLLHKGHSECPSGQSCIPILDDQCF 926
G C+ +G+ G CI CF
Sbjct: 339 GSYFCVCPRGYVTSTDGSRCIDQRTGMCF 367
Score = 79.0 bits (193), Expect = 3e-14
Identities = 78/299 (26%), Positives = 114/299 (38%), Gaps = 61/299 (20%)
Query: 212 CDQNGNKTCMEGWMGPECNRAICRQGCSPK--HGSCKLPGDCRCQYGWQGLYCDKCIPHP 269
C + TC G + C +Q CS + +G C+CQ G+ G YC + +
Sbjct: 124 CSRPNMCTCSSGQISSTCGSKSIQQ-CSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCEN 182
Query: 270 GCVH-GICNEPWQCLCETNWGGQLCDKDLNY--CGT---HQPC---LNGGTCSNTGPDKY 320
GC + G C P +C C + G C++D C T +Q C L G C+ T
Sbjct: 183 GCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKT----- 237
Query: 321 QCSCPEGYS-GPNCEIAEHACLSDPCH-------NRGSCKETSLGFECECSPGWTGPTCS 372
C G + G CE+ PC G+C++ EC+ PG
Sbjct: 238 LCCATIGRAWGHPCEMC--PAQPQPCRRGFIPNIRTGACQDVD---ECQAIPG------- 285
Query: 373 TNIDDCSPNNCSHGGTCQDLVNGFKCVCP----PQWTGKTCQLDANECEAKPCV-NAKSC 427
GG C + V F+C CP T + C+ D +EC P + C
Sbjct: 286 ----------ICQGGNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETGEC 334
Query: 428 KNLIASYYCDCLPGWM----GQNC-DININDCLGQCQNDASCRDL---VNGYRCICPPG 478
N + SY+C C G++ G C D C N ++L + +C C PG
Sbjct: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 203 bits (516), Expect = 9e-52
Identities = 87/222 (39%), Positives = 123/222 (55%), Gaps = 7/222 (3%)
Query: 232 AICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQ 291
A C C+P++G C+ CRCQ GWQG CD+C+ PGC+HG+C EP QC+C W G+
Sbjct: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
Query: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL--SDPCHNRG 349
LCD+D+ C + PC N GTC + Y+CSC GYSG +C+ + C+ PC + G
Sbjct: 84 LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
Query: 350 SCKE---TSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG 406
+C + + C C PG++G C + C+PN C + G C D+ F+C CP +
Sbjct: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
Query: 407 KTCQLDANECEAKPCVNAKSC-KNLIASYYCDCLPGWMGQNC 447
KTC C + PC N +C ++ SY C C P + G C
Sbjct: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 157 bits (396), Expect = 8e-38
Identities = 80/230 (34%), Positives = 114/230 (49%), Gaps = 19/230 (8%)
Query: 192 YGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDC 251
YG C C P++ F C+ + C GW GP C++ + GC HG C PG C
Sbjct: 22 YGAECFPACNPQNGF-----CEDDNVCRCQPGWQGPLCDQCVTSPGC--LHGLCGEPGQC 74
Query: 252 RCQYGWQGLYCDK----CIPHPGCVHGIC----NEPWQCLCETNWGGQLCDKDLNYCGTH 303
C GW G CD+ C P +G C + ++C C + G+ C K C +
Sbjct: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
Query: 304 -QPCLNGGTC-SNTGPDKY-QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC 360
PC +GGTC + G + C CP G+SG CEI ++C +PC N G C + F C
Sbjct: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
Query: 361 ECSPGWTGPTCSTNIDDCSPNNCSHGGTC-QDLVNGFKCVCPPQWTGKTC 409
C G+ TCS + +C+ + C +GGTC Q ++C+C P++TG TC
Sbjct: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 151 bits (381), Expect = 4e-36
Identities = 78/232 (33%), Positives = 109/232 (46%), Gaps = 17/232 (7%)
Query: 261 YCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320
Y +C P +G C + C C+ W G LCD+ C T CL+ G C G
Sbjct: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLH-GLCGEPG---- 72
Query: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCS 379
QC C +G+ G C+ AC S PC N G+C G +EC C+PG++G C C
Sbjct: 73 QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
Query: 380 PNN--CSHGGTCQD---LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY 434
N C HGGTC D + C+CPP ++G C++ AN C PC N C ++ +
Sbjct: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
Query: 435 YCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVN-GYRCICPPGYAGDHC 484
C C G++ + C + +C CQN +C Y C+C P + G C
Sbjct: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 149 bits (375), Expect = 2e-35
Identities = 74/221 (33%), Positives = 104/221 (47%), Gaps = 20/221 (9%)
Query: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPN-NCSHGGTCQDLVNGFKCVCPPQWTGK 407
G C++ ++ C C PGW GP C D C + C HG C + +C+C W G+
Sbjct: 35 GFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHG-LCGE---PGQCICTDGWDGE 83
Query: 408 TCQLDANECEAKPCVNAKSCKNLIASYY-CDCLPGWMGQNCDININDCL---GQCQNDAS 463
C D C + PC N +C +L Y C C PG+ G++C C+ CQ+ +
Sbjct: 84 LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
Query: 464 CRD---LVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520
C D + C+CPPG++G+ CE + C NPC N G C + F+C CP GF
Sbjct: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
Query: 521 LCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNC 560
C + C +PCQNG C Y C C ++ G C
Sbjct: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 144 bits (362), Expect = 7e-34
Identities = 72/210 (34%), Positives = 96/210 (45%), Gaps = 15/210 (7%)
Query: 653 CICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEA 712
C C GW+G C+ C +P G C + C C +GW G+ C C A
Sbjct: 43 CRCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
Query: 713 TCNNGGTCYDEGDA-FKCMCPGGWEGTTCNIARNSSCLPN--PCHNGGTCVVN---GESF 766
C N GTC D ++C C G+ G C ++ C+ N PC +GGTCV +
Sbjct: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRASHA 154
Query: 767 TCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQS 826
+C+C G+ G C N C+P+PC N G C D +RC C GF C + C S
Sbjct: 155 SCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCAS 214
Query: 827 SPCAFGATCVDEIN-GYRCVCPPGHSGAKC 855
SPC G TC+ Y C+C P +G C
Sbjct: 215 SPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 139 bits (350), Expect = 2e-32
Identities = 72/210 (34%), Positives = 102/210 (48%), Gaps = 25/210 (11%)
Query: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY--Y 435
C+P N G C+D C C P W G C CV + C + +
Sbjct: 30 CNPQN----GFCED---DNVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPGQ 73
Query: 436 CDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCICPPGYAGDHCERDIDECAS 493
C C GW G+ CD ++ C C N+ +C L +G Y C C PGY+G C++ C
Sbjct: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
Query: 494 N--PCLNGGHCQNEINRFQ---CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548
N PC +GG C ++ R CLCP GFSGN C++ + C PNPC+N C + D+
Sbjct: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
Query: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSC 578
C+CP + K CS +C ++PC+ +C
Sbjct: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
Score = 134 bits (338), Expect = 4e-31
Identities = 73/230 (31%), Positives = 103/230 (44%), Gaps = 34/230 (14%)
Query: 537 GAQCYNRAS--------DYFCKCPEDYEGKNCSHLKDHCRTTP------------CEVID 576
GA+C+ + D C+C ++G C D C T+P C D
Sbjct: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQCICTD 78
Query: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN 636
+ D VR SS C +G C S G + C C G++G C + C N
Sbjct: 79 GWDGELCDRD----VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
Query: 637 --PCRNGGTCIDG---VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYC 691
PC++GGTC+D + C+C G+ G +CE N C+ NPC N G C D+ DF C
Sbjct: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
Query: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD-AFKCMCPGGWEGTTC 740
C G+ KTC + C + C NGGTC +++C+C + G TC
Sbjct: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 86.3 bits (212), Expect = 2e-16
Identities = 60/192 (31%), Positives = 80/192 (41%), Gaps = 31/192 (16%)
Query: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
+ C P G C + C C+ GW+GP+C Q C P G C + +
Sbjct: 24 AECFPACNPQNGFCE---DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPG---Q 73
Query: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCI 864
C C G+ G C ++ C S+PCA TCV +G Y C C PG+SG CQ+ G PC+
Sbjct: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDG-PCV 132
Query: 865 TMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQ 924
GS G DD GR + + C P SG C I+ +
Sbjct: 133 INGSPCQHGGTCVDD-------EGRASHASCLCPPG-----------FSGNFC-EIVANS 173
Query: 925 CFVHPCTGVGEC 936
C +PC G C
Sbjct: 174 CTPNPCENDGVC 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.474
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,700,202
Number of Sequences: 37866
Number of extensions: 3459908
Number of successful extensions: 25754
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 240
Number of HSP's successfully gapped in prelim test: 277
Number of HSP's that attempted gapping in prelim test: 6775
Number of HSP's gapped (non-prelim): 5471
length of query: 1218
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1104
effective length of database: 13,930,794
effective search space: 15379596576
effective search space used: 15379596576
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.