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Search of human proteins with 4503271
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503271 decorin isoform a preproprotein [Homo sapiens]
(359 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 723 0.0
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 723 0.0
gi|4502403 biglycan preproprotein [Homo sapiens] 397 e-111
gi|41350214 asporin [Homo sapiens] 369 e-102
gi|19743848 decorin isoform b precursor [Homo sapiens] 365 e-101
gi|19743850 decorin isoform c precursor [Homo sapiens] 291 6e-79
gi|19743852 decorin isoform d precursor [Homo sapiens] 240 2e-63
gi|19743854 decorin isoform e precursor [Homo sapiens] 152 4e-37
gi|41349454 proline arginine-rich end leucine-rich repeat protei... 147 1e-35
gi|4506041 proline arginine-rich end leucine-rich repeat protein... 147 1e-35
gi|4505047 lumican precursor [Homo sapiens] 137 1e-32
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 134 2e-31
gi|45505137 podocan [Homo sapiens] 128 7e-30
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 125 8e-29
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 125 8e-29
gi|5901992 keratocan [Homo sapiens] 123 3e-28
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 122 4e-28
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 122 4e-28
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 121 1e-27
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 121 1e-27
gi|71040111 fibromodulin precursor [Homo sapiens] 120 2e-27
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 119 5e-27
gi|51317373 netrin-G1 ligand [Homo sapiens] 117 2e-26
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 116 3e-26
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 113 3e-25
gi|4826876 osteomodulin [Homo sapiens] 112 7e-25
gi|11321571 slit homolog 3 [Homo sapiens] 109 3e-24
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 109 3e-24
gi|188528675 slit homolog 1 [Homo sapiens] 109 4e-24
gi|4759146 slit homolog 2 [Homo sapiens] 105 6e-23
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 723 bits (1866), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
Sbjct: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
Query: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS
Sbjct: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
Query: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH
Sbjct: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 723 bits (1866), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
Sbjct: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
Query: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS
Sbjct: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
Query: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH
Sbjct: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
>gi|4502403 biglycan preproprotein [Homo sapiens]
Length = 368
Score = 397 bits (1020), Expect = e-111
Identities = 202/362 (55%), Positives = 257/362 (70%), Gaps = 10/362 (2%)
Query: 7 LLLLAQVSWAGPFQQRGLFDFMLED--------EASGIGPE-VPDDRDFEPSLGPVCPFR 57
L+ L +S A PF+QRG +DF L+D EASG V D P+ +CPF
Sbjct: 7 LVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFG 66
Query: 58 CQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
C CHLRVVQCSDLGL VPK++ PDTTLLDLQNN I+E++ DFK L++L+AL+LVNNKI
Sbjct: 67 CHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKI 126
Query: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMI 177
SK+ AF+PL KL++LY+SKN L E+P +P +L ELR H+N I KV K F+GL M
Sbjct: 127 SKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMN 186
Query: 178 VIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVD 237
IE+G NPL++SG E GAF G+ KL+Y+RI++ +T IP+ LP +L ELHLD NKI ++
Sbjct: 187 CIEMGGNPLENSGFEPGAFDGL-KLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIE 245
Query: 238 AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
L + L +LGL N I ++NGSL+ P LRELHLDNNKL RVP GL + K +QVV
Sbjct: 246 LEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVV 305
Query: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGN 357
YLH+NNI+ VG +DFCP G K+A Y+G+SLF+NPV YWE+QP+TFRCV R AIQ GN
Sbjct: 306 YLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGN 365
Query: 358 YK 359
YK
Sbjct: 366 YK 367
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 369 bits (947), Expect = e-102
Identities = 191/380 (50%), Positives = 256/380 (67%), Gaps = 24/380 (6%)
Query: 1 MKATIILLLLAQVSWAGPF---QQRGLFDFMLEDEASGIGPEVPDDRD------------ 45
MK ++LL LA S A PF L + ML+D + DD D
Sbjct: 1 MKEYVLLLFLALCS-AKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPT 59
Query: 46 -------FEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKD 98
F L P+CPF CQC+ RVV CSDLGL VP ++P DT +LDLQNNKI EIK+
Sbjct: 60 REPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKE 119
Query: 99 GDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAH 158
DFK L +L+ LIL NNK++K+ P AF KL RLYLS NQL E+P +PK+L ELR H
Sbjct: 120 NDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIH 179
Query: 159 ENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQG 218
EN++ K++K TF G+N + V+E+ NPL ++GIE GAF+G+ + +IRIA+ +TS+P+G
Sbjct: 180 ENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVT-VFHIRIAEAKLTSVPKG 238
Query: 219 LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDN 278
LPP+L ELHLD NKIS V+ K L +LGL N I+ ++NGSLAN P +RE+HL+N
Sbjct: 239 LPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLEN 298
Query: 279 NKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWE 338
NKL ++P GL E KY+Q+++LH+N+I+ VG +DFCP KK+ YS +SLF+NPV+YWE
Sbjct: 299 NKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWE 358
Query: 339 IQPSTFRCVYVRSAIQLGNY 358
+QP+TFRCV R ++QLGN+
Sbjct: 359 MQPATFRCVLSRMSVQLGNF 378
>gi|19743848 decorin isoform b precursor [Homo sapiens]
Length = 250
Score = 365 bits (938), Expect = e-101
Identities = 180/181 (99%), Positives = 181/181 (100%)
Query: 179 IELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA 238
+ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA
Sbjct: 70 LELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA 129
Query: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY 298
ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY
Sbjct: 130 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY 189
Query: 299 LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY 358
LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY
Sbjct: 190 LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY 249
Query: 359 K 359
K
Sbjct: 250 K 250
Score = 184 bits (467), Expect = 1e-46
Identities = 112/254 (44%), Positives = 139/254 (54%), Gaps = 51/254 (20%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDL-------------------------------GLDKVPKDLPPDTTLLDLQ 89
HLRVVQCSDL + +P+ LPP T L L
Sbjct: 61 HLRVVQCSDLELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 120
Query: 90 NNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMP 149
NKI+ + K L NL L L N IS V G+ L L+L N+L +P +
Sbjct: 121 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLA 180
Query: 150 --KTLQELRAHENEITKV------------RKVTFNGLNQMIVIELGTNPLKSSGIENGA 195
K +Q + H N I+ V +K +++G + L +NP++ I+
Sbjct: 181 EHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSG------VSLFSNPVQYWEIQPST 234
Query: 196 FQGMKKLSYIRIAD 209
F+ + S I++ +
Sbjct: 235 FRCVYVRSAIQLGN 248
>gi|19743850 decorin isoform c precursor [Homo sapiens]
Length = 212
Score = 291 bits (745), Expect = 6e-79
Identities = 142/142 (100%), Positives = 142/142 (100%)
Query: 218 GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 277
GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD
Sbjct: 71 GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 130
Query: 278 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW 337
NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW
Sbjct: 131 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW 190
Query: 338 EIQPSTFRCVYVRSAIQLGNYK 359
EIQPSTFRCVYVRSAIQLGNYK
Sbjct: 191 EIQPSTFRCVYVRSAIQLGNYK 212
Score = 191 bits (486), Expect = 7e-49
Identities = 112/223 (50%), Positives = 136/223 (60%), Gaps = 27/223 (12%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
HLRVVQCSDLG LPP T L L NKI+ + K L NL L L N IS V
Sbjct: 61 HLRVVQCSDLG-------LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 113
Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMP--KTLQELRAHENEITKV------------R 166
G+ L L+L N+L +P + K +Q + H N I+ V +
Sbjct: 114 DNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTK 173
Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIAD 209
K +++G + L +NP++ I+ F+ + S I++ +
Sbjct: 174 KASYSG------VSLFSNPVQYWEIQPSTFRCVYVRSAIQLGN 210
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 148 MPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRI 207
+P +L EL N+I++V + GLN + + L N + S ++NG+ L + +
Sbjct: 72 LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHL 129
Query: 208 ADTNITSIPQGLPPS--LTELHLDGNKISRVDAA 239
+ +T +P GL + ++L N IS V ++
Sbjct: 130 DNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSS 163
>gi|19743852 decorin isoform d precursor [Homo sapiens]
Length = 172
Score = 240 bits (612), Expect = 2e-63
Identities = 116/127 (91%), Positives = 117/127 (92%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLH + L NN IS V
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVV 120
Query: 121 SPGAFTP 127
F P
Sbjct: 121 GSSDFCP 127
Score = 149 bits (375), Expect = 5e-36
Identities = 73/92 (79%), Positives = 78/92 (84%), Gaps = 1/92 (1%)
Query: 269 PHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGV 327
P L L NNK+T + G ++ K + VVYLHNNNISVVGSSDFCPPGHNTKKASYSGV
Sbjct: 81 PDTTLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVVGSSDFCPPGHNTKKASYSGV 140
Query: 328 SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 141 SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 172
>gi|19743854 decorin isoform e precursor [Homo sapiens]
Length = 75
Score = 152 bits (384), Expect = 4e-37
Identities = 71/71 (100%), Positives = 71/71 (100%)
Query: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1 MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
Query: 61 HLRVVQCSDLG 71
HLRVVQCSDLG
Sbjct: 61 HLRVVQCSDLG 71
>gi|41349454 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 147 bits (372), Expect = 1e-35
Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 15/289 (5%)
Query: 32 EASGIGPEVPDDRDFEPSLGPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDL 88
E + + P +P PS+ P CP C C + C L KVP +PP L L
Sbjct: 54 EPTDLPPPLPPG---PPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHYLYL 109
Query: 89 QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148
QNN ITE+ F+N L + L NN+I K+ L L LY+ KNQL+E+P +
Sbjct: 110 QNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSAL 169
Query: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
P+ L++LR +N I+++ F+ L +++++L N L + F G+K L + +A
Sbjct: 170 PRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLA 229
Query: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG---SL 265
+ +P +P ++ +L+LD NKI + K NLA + L++N ++ D G +
Sbjct: 230 HNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLT--DRGLPKNS 287
Query: 266 ANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
N +L LHL +N+++ VP A + ++ +YL+NN+I + + CP
Sbjct: 288 FNISNLLVLHLSHNRISSVP---AINNRLEHLYLNNNSIEKINGTQICP 333
>gi|4506041 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 147 bits (372), Expect = 1e-35
Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 15/289 (5%)
Query: 32 EASGIGPEVPDDRDFEPSLGPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDL 88
E + + P +P PS+ P CP C C + C L KVP +PP L L
Sbjct: 54 EPTDLPPPLPPG---PPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHYLYL 109
Query: 89 QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148
QNN ITE+ F+N L + L NN+I K+ L L LY+ KNQL+E+P +
Sbjct: 110 QNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSAL 169
Query: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
P+ L++LR +N I+++ F+ L +++++L N L + F G+K L + +A
Sbjct: 170 PRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLA 229
Query: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG---SL 265
+ +P +P ++ +L+LD NKI + K NLA + L++N ++ D G +
Sbjct: 230 HNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLT--DRGLPKNS 287
Query: 266 ANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
N +L LHL +N+++ VP A + ++ +YL+NN+I + + CP
Sbjct: 288 FNISNLLVLHLSHNRISSVP---AINNRLEHLYLNNNSIEKINGTQICP 333
>gi|4505047 lumican precursor [Homo sapiens]
Length = 338
Score = 137 bits (345), Expect = 1e-32
Identities = 101/323 (31%), Positives = 159/323 (49%), Gaps = 17/323 (5%)
Query: 43 DRDFEPSL----GPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITE 95
D DF S+ P C C C + + C +L L VP +PP L L+NN+I
Sbjct: 22 DYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDH 80
Query: 96 IKDGDFKNLKNLHALILVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQ 153
I + F+N+ +L LIL +N + SK+ F+ L +L++L+++ N L E +PK+L+
Sbjct: 81 IDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLE 140
Query: 154 ELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNIT 213
+L+ N+ITK+ +F GL + I L N LK + + AF+G+K L Y+ ++ I
Sbjct: 141 DLQLTHNKITKLG--SFEGLVNLTFIHLQHNRLKEDAV-SAAFKGLKSLEYLDLSFNQIA 197
Query: 214 SIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS-AVDNGSLANTPHLR 272
+P GLP SL L+LD NKIS + K N L L LS N ++ + G+ N L
Sbjct: 198 RLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLV 257
Query: 273 ELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSN 332
EL L NKL +P ++ ++ YL N + FC + + L N
Sbjct: 258 ELDLSYNKLKNIP---TVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGN 314
Query: 333 PVQYWEIQPSTFRCVYVRSAIQL 355
+ + P + C+ V + + L
Sbjct: 315 RISETSLPPDMYECLRVANEVTL 337
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 134 bits (336), Expect = 2e-31
Identities = 83/251 (33%), Positives = 125/251 (49%), Gaps = 5/251 (1%)
Query: 55 PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVN 114
P C R + C + L ++P P T L+L N I I D F L NL L L
Sbjct: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
Query: 115 NKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
N I S + P AF L KL RL + N L ++P ++P TL+EL+ +EN + + + + +
Sbjct: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
Query: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
LNQ++ +EL N L + + AF+ +K L+Y+R+ IPQGLP S+ EL+L+ N+
Sbjct: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
Query: 233 ISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAE 290
I + + + L +N I LA N +L + L NKL VP L +
Sbjct: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPK 556
Query: 291 HKYIQVVYLHN 301
+ +V L N
Sbjct: 557 -SLLHLVLLGN 566
Score = 117 bits (293), Expect = 2e-26
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 7/290 (2%)
Query: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLV 129
L ++P LP L + N + I + +L L L L N +S+ V+P AF PL
Sbjct: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
L L L KN+ + +P+ +P +++EL N+I ++ ++ FN ++ VI L N ++ +
Sbjct: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524
Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLN-NLA 248
I A+ + L I ++ + +P LP SL L L GN+I R+ + L
Sbjct: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584
Query: 249 KLGLSFNSIS--AVDNGSLANTPH-LRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 305
L LSFN ++ +D S H LREL LD+N L +P G+ E K + + L+NN I
Sbjct: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644
Query: 306 VVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
+ + C ++ + L +N ++ EI TF C+ S+I L
Sbjct: 645 NILPEEIC-NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 128 bits (322), Expect = 7e-30
Identities = 95/328 (28%), Positives = 153/328 (46%), Gaps = 23/328 (7%)
Query: 26 DFMLEDEASGIGPEVPDDRDFEPSLGPV---CPFRCQCHLR-VVQCSDLGLDKVPKDLPP 81
+F E+ + PE EP GP CP C C VV C + L + P DLP
Sbjct: 92 EFAEEEPVLVLSPE-------EPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPE 144
Query: 82 DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLVKLERLYLSKN 139
T L LQNN++ +I + L L L L NN+++ + AF L L LYL+ N
Sbjct: 145 HTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN 204
Query: 140 QLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGM 199
+L P +P L + N +TK+ +TF + + L N L +G+ + F G
Sbjct: 205 KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGS 264
Query: 200 KKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS- 258
+ + ++ + +P+ LPP+L +LHL NK+ ++ + L++L +L L N ++
Sbjct: 265 SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324
Query: 259 -AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGH 317
+DN + L L L +N L+RVP GL + + +++L N I V ++ P
Sbjct: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLP--RSLVLLHLEKNAIRSVDANVLTP--- 379
Query: 318 NTKKASYSGVSLFSNPVQYWEIQPSTFR 345
S + L SN ++ I P F+
Sbjct: 380 ---IRSLEYLLLHSNQLREQGIHPLAFQ 404
Score = 112 bits (279), Expect = 7e-25
Identities = 79/265 (29%), Positives = 126/265 (47%), Gaps = 6/265 (2%)
Query: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
P F +L + ++ L P+ LP +D N +T+I F NL ++
Sbjct: 186 PEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVY 245
Query: 112 LVNNKISKVS--PGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
L NNK++ F +E L LS N L+ +P+ +P L +L N++ K+
Sbjct: 246 LHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGA 305
Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
F+ L+ + + L N L G++N F + L Y+ ++ N++ +P GLP SL LHL+
Sbjct: 306 FSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLE 365
Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGG 287
N I VDA L + +L L L N + LA L +HL NN L RVP G
Sbjct: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425
Query: 288 LAEHKYIQVVYLHNNNISVVGSSDF 312
L + ++ + + +N I+ +G DF
Sbjct: 426 LP--RRVRTLMILHNQITGIGREDF 448
Score = 105 bits (262), Expect = 6e-23
Identities = 74/243 (30%), Positives = 116/243 (47%), Gaps = 4/243 (1%)
Query: 56 FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
F ++ V+ S L VPK LPP L L+NNK+ +I G F L +L L L NN
Sbjct: 261 FNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN 320
Query: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
++ + F L LE L LS N L +P +P++L L +N I V +
Sbjct: 321 YLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI 380
Query: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
+ + L +N L+ GI AFQG+K+L + + + + +P GLP + L + N+I
Sbjct: 381 RSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQI 440
Query: 234 SRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
+ + L +L LS+N I++ V + LR L L N+L +P GL +
Sbjct: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500
Query: 292 KYI 294
++
Sbjct: 501 VHV 503
Score = 104 bits (259), Expect = 1e-22
Identities = 75/288 (26%), Positives = 140/288 (48%), Gaps = 12/288 (4%)
Query: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK-- 119
L + S L +VP LP LL L+ N I + +++L L+L +N++ +
Sbjct: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
+ P AF L +L ++L N L+ +P +P+ ++ L N+IT + + F + +
Sbjct: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
L N + S + AF+ ++ L + ++ + ++P GLP ++ L + N+++ +
Sbjct: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
Query: 240 SLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
+L G+ L +L L+ N + + G A + HL+ L + N+LT +P GL E ++ +
Sbjct: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES--LEYL 575
Query: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFR 345
YL NN IS V ++ F + G+ L N + + S FR
Sbjct: 576 YLQNNKISAVPANAF------DSTPNLKGIFLRFNKLAVGSVVDSAFR 617
Score = 99.8 bits (247), Expect = 3e-21
Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 4/222 (1%)
Query: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--K 119
L V + L++VP LP L + +N+IT I DF L L L N+I+ +
Sbjct: 409 LHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ 468
Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
V AF L L L LS N+L LP +P+ + L+ NE+ + + G+ Q+ +
Sbjct: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528
Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
L +N L+S + A+ + L + IA +T IP+GLP SL L+L NKIS V A
Sbjct: 529 YLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPAN 588
Query: 240 SLKGLNNLAKLGLSFN--SISAVDNGSLANTPHLRELHLDNN 279
+ NL + L FN ++ +V + + HL+ L ++ N
Sbjct: 589 AFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNK--IS 118
HL+++ + L ++P+ LP L LQNNKI+ + F + NL + L NK +
Sbjct: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609
Query: 119 KVSPGAFTPLVKLERLYLSKN 139
V AF L L+ L + N
Sbjct: 610 SVVDSAFRRLKHLQVLDIEGN 630
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 125 bits (313), Expect = 8e-29
Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C+C + C+D L +P +P D T L LQNN+I G +LKNL
Sbjct: 31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
+K+ER+YL N L E P +PK ++EL EN I R +T++ L
Sbjct: 83 ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124
Query: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
+++ +E L N + + IE GAF+ L + ++ ++++IP GLP ++ EL LD
Sbjct: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
N+IS + + SL+GL +L +L L N ++ + + N +L EL L N LT P L
Sbjct: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244
Query: 289 AEHKYIQVVYLHNNNISVVGSSDF 312
++ +YL +N+I+ V + F
Sbjct: 245 PGTN-LRKLYLQDNHINRVPPNAF 267
Score = 37.0 bits (84), Expect = 0.027
Identities = 19/41 (46%), Positives = 26/41 (63%)
Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE 146
NL L L +N I++V P AF+ L +L RL +S N L LP+
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288
Score = 35.0 bits (79), Expect = 0.10
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 72 LDKVPKDLP-PDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
L P +LP + L LQ+N I + F L+ L+ L + NN +S + G F L
Sbjct: 237 LTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Query: 131 LERLYLSKN 139
+ +L L N
Sbjct: 297 ITQLILRNN 305
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 125 bits (313), Expect = 8e-29
Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C+C + C+D L +P +P D T L LQNN+I G +LKNL
Sbjct: 31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
+K+ER+YL N L E P +PK ++EL EN I R +T++ L
Sbjct: 83 ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124
Query: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
+++ +E L N + + IE GAF+ L + ++ ++++IP GLP ++ EL LD
Sbjct: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
N+IS + + SL+GL +L +L L N ++ + + N +L EL L N LT P L
Sbjct: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244
Query: 289 AEHKYIQVVYLHNNNISVVGSSDF 312
++ +YL +N+I+ V + F
Sbjct: 245 PGTN-LRKLYLQDNHINRVPPNAF 267
Score = 37.0 bits (84), Expect = 0.027
Identities = 19/41 (46%), Positives = 26/41 (63%)
Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE 146
NL L L +N I++V P AF+ L +L RL +S N L LP+
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288
Score = 35.0 bits (79), Expect = 0.10
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 72 LDKVPKDLP-PDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
L P +LP + L LQ+N I + F L+ L+ L + NN +S + G F L
Sbjct: 237 LTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Query: 131 LERLYLSKN 139
+ +L L N
Sbjct: 297 ITQLILRNN 305
>gi|5901992 keratocan [Homo sapiens]
Length = 352
Score = 123 bits (308), Expect = 3e-28
Identities = 80/269 (29%), Positives = 140/269 (52%), Gaps = 14/269 (5%)
Query: 54 CPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
CP C C + C + GL ++P +P L LQNN I I + F+N L +
Sbjct: 42 CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100
Query: 111 ILVNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV 168
L NKI+ + GA + L KL L+L N+L+E+P +P++L++L+ N+++++ +
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160
Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHL 228
TF+ L + +++L N L + + F+G+K L + +A + ++P LP + +L L
Sbjct: 161 TFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFL 220
Query: 229 DGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA---NTPHLRELHLDNNKLTRVP 285
D N I + + +A L L+ N +S D G + + + +L L +N+LT+VP
Sbjct: 221 DNNSIEGIPENYFNVIPKVAFLRLNHNKLS--DEGLPSRGFDVSSILDLQLSHNQLTKVP 278
Query: 286 GGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
A ++Q ++L +N I V S CP
Sbjct: 279 RISA---HLQHLHLDHNKIKSVNVSVICP 304
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 122 bits (307), Expect = 4e-28
Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)
Query: 54 CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
CP RC C + V C L L P ++ L LQNN++ E+ + L L L L
Sbjct: 44 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103
Query: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
NN IS + AF L +L+ L ++ N+L P+ +P++L+ N++ ++ +TF
Sbjct: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 163
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
+ + L N L ++G+ AF+G + ++ + +++ ++ +P LPPSL LHL
Sbjct: 164 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 223
Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
N IS+V +L L +L L N + S +D + + L L L +N+LT VP GL
Sbjct: 224 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
Query: 289 AEHKYIQVVYLHNNNISVV 307
+ + +++L N I V
Sbjct: 284 P--RTLAILHLGRNRIRQV 300
Score = 117 bits (292), Expect = 2e-26
Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)
Query: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
L P+ LP + DL N++ EI F L ++ L NN++S P AF
Sbjct: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
+ L LS NQL LP +P +L+ L N I+KV + + Q+ + L N L S
Sbjct: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
G++ F + L Y+ ++ +T++P GLP +L LHL N+I +V+AA L G L
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
Query: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
L L N + S + G+L L LHL N L RVP L + ++ + L +N+++ +
Sbjct: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371
Query: 308 GSSDF-CPPGHNTKKASYS 325
G+ D PG +Y+
Sbjct: 372 GARDLVATPGLTELNLAYN 390
Score = 102 bits (255), Expect = 4e-22
Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)
Query: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
P FR + + S+ L +P LPP L LQNN I+++ G L L
Sbjct: 185 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 244
Query: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
L +N++ S + F+ L LE L LS NQL +P +P+TL L N I +V
Sbjct: 245 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 304
Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
+G + + L N L SSG+ GA + ++ L + + + +P LP L L L
Sbjct: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 364
Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
N ++ + A L L +L L++N +++ V + + LR L L N+LTR+P G
Sbjct: 365 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 424
Query: 288 L 288
L
Sbjct: 425 L 425
Score = 84.3 bits (207), Expect = 1e-16
Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)
Query: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
L + S L VP LP +L L N+I +++ + L L+L +N++ S
Sbjct: 266 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 325
Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
+ GA PL L L+L N L +P +P+ L+ L N + + + +
Sbjct: 326 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 385
Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
L N L S+ + + AF+ ++ L + +A +T +P GLP L L L N++ ++
Sbjct: 386 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 445
Query: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
L GL+ L +L L+ N + D G
Sbjct: 446 PLAGLDQLRELSLAHNRLRVGDIG 469
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)
Query: 71 GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
GLD+VP LP L L +N + + D L L L N+++ +V AF L
Sbjct: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
Query: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
L L L+ NQL LP +P L+ L+ N++ + GL+Q+ + L N L+
Sbjct: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
Query: 189 SGIENGAFQGMKKL 202
I G + ++ L
Sbjct: 466 GDIGPGTWHELQAL 479
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 122 bits (307), Expect = 4e-28
Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)
Query: 54 CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
CP RC C + V C L L P ++ L LQNN++ E+ + L L L L
Sbjct: 46 CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 105
Query: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
NN IS + AF L +L+ L ++ N+L P+ +P++L+ N++ ++ +TF
Sbjct: 106 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 165
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
+ + L N L ++G+ AF+G + ++ + +++ ++ +P LPPSL LHL
Sbjct: 166 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 225
Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
N IS+V +L L +L L N + S +D + + L L L +N+LT VP GL
Sbjct: 226 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 285
Query: 289 AEHKYIQVVYLHNNNISVV 307
+ + +++L N I V
Sbjct: 286 P--RTLAILHLGRNRIRQV 302
Score = 117 bits (292), Expect = 2e-26
Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)
Query: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
L P+ LP + DL N++ EI F L ++ L NN++S P AF
Sbjct: 136 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 195
Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
+ L LS NQL LP +P +L+ L N I+KV + + Q+ + L N L S
Sbjct: 196 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 255
Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
G++ F + L Y+ ++ +T++P GLP +L LHL N+I +V+AA L G L
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 315
Query: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
L L N + S + G+L L LHL N L RVP L + ++ + L +N+++ +
Sbjct: 316 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 373
Query: 308 GSSDF-CPPGHNTKKASYS 325
G+ D PG +Y+
Sbjct: 374 GARDLVATPGLTELNLAYN 392
Score = 102 bits (255), Expect = 4e-22
Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)
Query: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
P FR + + S+ L +P LPP L LQNN I+++ G L L
Sbjct: 187 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 246
Query: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
L +N++ S + F+ L LE L LS NQL +P +P+TL L N I +V
Sbjct: 247 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 306
Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
+G + + L N L SSG+ GA + ++ L + + + +P LP L L L
Sbjct: 307 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 366
Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
N ++ + A L L +L L++N +++ V + + LR L L N+LTR+P G
Sbjct: 367 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 426
Query: 288 L 288
L
Sbjct: 427 L 427
Score = 84.3 bits (207), Expect = 1e-16
Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)
Query: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
L + S L VP LP +L L N+I +++ + L L+L +N++ S
Sbjct: 268 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 327
Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
+ GA PL L L+L N L +P +P+ L+ L N + + + +
Sbjct: 328 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 387
Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
L N L S+ + + AF+ ++ L + +A +T +P GLP L L L N++ ++
Sbjct: 388 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 447
Query: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
L GL+ L +L L+ N + D G
Sbjct: 448 PLAGLDQLRELSLAHNRLRVGDIG 471
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)
Query: 71 GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
GLD+VP LP L L +N + + D L L L N+++ +V AF L
Sbjct: 348 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 407
Query: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
L L L+ NQL LP +P L+ L+ N++ + GL+Q+ + L N L+
Sbjct: 408 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 467
Query: 189 SGIENGAFQGMKKL 202
I G + ++ L
Sbjct: 468 GDIGPGTWHELQAL 481
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 121 bits (303), Expect = 1e-27
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 11/269 (4%)
Query: 52 PVCPFRCQCHL-RVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
P+C C C R V CS GL VP+ L T LD+ N IT++ + FKN L L
Sbjct: 27 PLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL 86
Query: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRK 167
L N +S + P A + L +L+ L L NQLK +P + + LQ LR N IT V +
Sbjct: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
Query: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGL---PPSLT 224
+F GL Q+ + L N L + + L + +A I+SIP SL
Sbjct: 147 DSFEGLVQLRHLWLDDNSLTEVPVH--PLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
Query: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRV 284
LHL NKI + GL+NL L L++N++ ++ P L+EL +N ++ +
Sbjct: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVI 263
Query: 285 PGGLAE-HKYIQVVYLHNNNISVVGSSDF 312
P G + + ++ ++L++N +S VG+S F
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
Score = 74.3 bits (181), Expect = 2e-13
Identities = 82/287 (28%), Positives = 112/287 (39%), Gaps = 55/287 (19%)
Query: 52 PVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
P F LR + D L +VP P L L NKI+ I D F NL +L
Sbjct: 145 PEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
Query: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE--KMPKTLQELRAHENEITKVR 166
L L NNKI +S F L LE L L+ N L E P+ K +L+EL H N I+ +
Sbjct: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264
Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQ-----------------------GMKKLS 203
F+G + I L NPL G N AF G L
Sbjct: 265 DGAFDGNPLLRTIHLYDNPLSFVG--NSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322
Query: 204 YIRIADTNITSIPQGLPP-------------------------SLTELHLDGNKISRVDA 238
+ + T I+SIP L +L E+ L N+I ++
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382
Query: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
+ +GL +L L LS N I + + + A + L + N+LT P
Sbjct: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 8/125 (6%)
Query: 61 HLRVVQCSDLGLDKVPKDLPPDTTLL---DLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
HL + + + +P +L + +L DL N I ++ F L + L N+I
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
Query: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL---QELRAHENEITKVRKVTFNGLN 174
++ G F L+ L L LS+N + E+ + TL L NE+T NGLN
Sbjct: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437
Query: 175 QMIVI 179
Q+ ++
Sbjct: 438 QLKLV 442
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 121 bits (303), Expect = 1e-27
Identities = 78/254 (30%), Positives = 128/254 (50%), Gaps = 26/254 (10%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C+C + C+D GL +P D+P D T L LQNN+I G ++LK
Sbjct: 54 CPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNA--GIPQDLKTK------ 105
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
V ++ +YL +N L E P +P++L+EL +N + + + + +
Sbjct: 106 ---------------VNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARI 150
Query: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
+ + L N + + IE AF K+L + ++ +++SIP GLP +L EL LD N+I
Sbjct: 151 PLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRI 210
Query: 234 SRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
S + + KGLN+L +L L N ++ + + + + +L EL L N L P L
Sbjct: 211 STIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPS- 269
Query: 292 KYIQVVYLHNNNIS 305
++Q +YL +N IS
Sbjct: 270 AHLQKLYLQDNAIS 283
Score = 30.4 bits (67), Expect = 2.6
Identities = 18/54 (33%), Positives = 26/54 (48%)
Query: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKN 139
L LQ+N I+ I ++ L L L NN ++ + G F L L +L L N
Sbjct: 275 LYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 328
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 120 bits (301), Expect = 2e-27
Identities = 85/284 (29%), Positives = 140/284 (49%), Gaps = 25/284 (8%)
Query: 38 PEVPDDRDFEPSLGPVCPFRCQCHLR---VVQCSDLGLDKVPKDLPPDTTLLDLQNNKIT 94
P PD RD CP C C + C + L +P +P + QNN+IT
Sbjct: 68 PSPPDPRD--------CPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQIT 118
Query: 95 EIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL 152
I++G F N L + L N+I+ KV F+ L LERLYL N L +P +P++L
Sbjct: 119 SIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSL 178
Query: 153 QELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 212
+EL N+I++V GL + + L N ++ G + +G++ L + ++ ++
Sbjct: 179 RELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHL 235
Query: 213 TSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANT---P 269
+P GLP +L +L+++ N + V + +G L + LS NS++ +NG +NT
Sbjct: 236 RKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLT--NNGLASNTFNSS 293
Query: 270 HLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFC 313
L EL L N+L ++P + ++ +YL N I+ S FC
Sbjct: 294 SLLELDLSYNQLQKIP---PVNTNLENLYLQGNRINEFSISSFC 334
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 119 bits (297), Expect = 5e-27
Identities = 92/280 (32%), Positives = 137/280 (48%), Gaps = 19/280 (6%)
Query: 47 EPSLGPV-CPFRCQCH----LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDF 101
+P GP CP C C + CS+LGL VP DL P T LDL N +TE++ G F
Sbjct: 27 QPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLF 86
Query: 102 KNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE----KMPKTLQELRA 157
+L+ L L L N +S + AF+ L L+ L L NQL +P ++P +LQ LR
Sbjct: 87 HHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELP-SLQSLRL 145
Query: 158 HENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP- 216
N I+ V + +F GL+ + + L N L + A + L + +A I+ IP
Sbjct: 146 DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR--ALNNLPALQAMTLALNRISHIPD 203
Query: 217 ---QGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRE 273
Q L SL LHL N+I + S +GL+NL L L++N + ++ L+E
Sbjct: 204 YAFQNL-TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQE 261
Query: 274 LHLDNNKLTRVP-GGLAEHKYIQVVYLHNNNISVVGSSDF 312
L NN + +P + +Q ++ ++N I VG S F
Sbjct: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 301
Score = 74.3 bits (181), Expect = 2e-13
Identities = 81/305 (26%), Positives = 129/305 (42%), Gaps = 38/305 (12%)
Query: 49 SLGPVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLK 105
SL P F LR + D L ++P + P + L N+I+ I D F+NL
Sbjct: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210
Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKT--LQELRAHENEIT 163
+L L L NN+I + +F L LE L L+ N+L+E P + LQEL H N I
Sbjct: 211 SLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIK 270
Query: 164 KVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSL 223
+ + F G + I NP++ F G Y+ P L
Sbjct: 271 AIPEKAFMGNPLLQTIHFYDNPIQ--------FVGRSAFQYL---------------PKL 307
Query: 224 TELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTR 283
L L+G + + LKG +L L L+ I + +G P LR L L +N++
Sbjct: 308 HTLSLNG-AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE 366
Query: 284 VPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPST 343
+P L + ++ + L +N I +G+ F ++ +S + L N ++ I P
Sbjct: 367 LP-SLHRCQKLEEIGLQHNRIWEIGADTF------SQLSSLQALDLSWNAIR--SIHPEA 417
Query: 344 FRCVY 348
F ++
Sbjct: 418 FSTLH 422
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 62 LRVVQCSDLGLDKVPK-DLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
LRV++ S ++++P + LQ+N+I EI F L +L AL L N I +
Sbjct: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413
Query: 121 SPGAFTPLVKLERLYLSKNQLKELP 145
P AF+ L L +L L+ NQL LP
Sbjct: 414 HPEAFSTLHSLVKLDLTDNQLTTLP 438
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 117 bits (292), Expect = 2e-26
Identities = 83/256 (32%), Positives = 125/256 (48%), Gaps = 8/256 (3%)
Query: 54 CPFRCQC--HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
CP C C V C L +VP + +T LL+L N+I IK FK+L++L L
Sbjct: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106
Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE---KMPKTLQELRAHENEITKVRKV 168
L N I + GAF L L L L N+L +P L+EL N I +
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP-PSLTELH 227
FN + + ++LG + S I GAF+G+ L Y+ +A N+ IP P L EL
Sbjct: 167 AFNRIPSLRRLDLG-ELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELD 225
Query: 228 LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGG 287
L GN +S + S +GL +L KL + + I ++ + N L E++L +N LT +P
Sbjct: 226 LSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHD 285
Query: 288 L-AEHKYIQVVYLHNN 302
L +++ ++LH+N
Sbjct: 286 LFTPLHHLERIHLHHN 301
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 7/210 (3%)
Query: 107 LHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVR 166
L L++ ++ P + + ++ + L+E+P+ + + L HEN+I ++
Sbjct: 33 LQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92
Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQG---LPPSL 223
+F L + +++L N +++ IE GAF G+ L+ + + D +T+IP G L
Sbjct: 93 VNSFKHLRHLEILQLSRNHIRT--IEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKL 150
Query: 224 TELHLDGNKISRVDAASLKGLNNLAKLGL-SFNSISAVDNGSLANTPHLRELHLDNNKLT 282
EL L N I + + + + +L +L L +S + G+ +LR L+L L
Sbjct: 151 KELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLR 210
Query: 283 RVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
+P L + + L N++S + F
Sbjct: 211 EIP-NLTPLIKLDELDLSGNHLSAIRPGSF 239
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 116 bits (291), Expect = 3e-26
Identities = 82/262 (31%), Positives = 127/262 (48%), Gaps = 9/262 (3%)
Query: 49 SLGPV-CPFRCQC--HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLK 105
S GP CP C C V C+ GL +VP+ +P +T L+L N I I+ F++L
Sbjct: 40 SAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLH 99
Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE---KMPKTLQELRAHENEI 162
+L L L N I ++ GAF L L L L N L +P + L+EL N I
Sbjct: 100 HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 163 TKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP-P 221
+ FN + ++ ++LG K I GAF+G+ L Y+ + NI +P P
Sbjct: 160 ESIPSYAFNRVPSLMRLDLG-ELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV 218
Query: 222 SLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 281
L EL + GN + S GL++L KL + + +S ++ + L EL+L +N L
Sbjct: 219 GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNL 278
Query: 282 TRVPGGL-AEHKYIQVVYLHNN 302
+ +P L +Y+ ++LH+N
Sbjct: 279 SSLPHDLFTPLRYLVELHLHHN 300
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 113 bits (282), Expect = 3e-25
Identities = 82/271 (30%), Positives = 132/271 (48%), Gaps = 15/271 (5%)
Query: 54 CPFRCQCH-----LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
CP C C L V CSDLGL ++P +L T+ LDL N I+++ +L+ L
Sbjct: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
Query: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKV 165
L L N ++ + GAFT L L+ L L NQL+ +P + ++LQ LR N I+ V
Sbjct: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 166 RKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQ---GLPPS 222
F+GL+ + + L N L ++ AF+ + L + +A I IP G S
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQ--AFRSLSALQAMTLALNKIHHIPDYAFGNLSS 211
Query: 223 LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT 282
L LHL N+I + GL++L L L++N++ ++ +L+EL +N +
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIR 270
Query: 283 RVP-GGLAEHKYIQVVYLHNNNISVVGSSDF 312
+P + + ++ ++N I VG S F
Sbjct: 271 SIPEKAFVGNPSLITIHFYDNPIQFVGRSAF 301
Score = 54.7 bits (130), Expect = 1e-07
Identities = 68/259 (26%), Positives = 92/259 (35%), Gaps = 72/259 (27%)
Query: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELP 145
+ L NKI I D F NL +L L L NN+I + F L LE L L+ N L E P
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 146 EKMP--KTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIE----------- 192
+ L+EL H N I + + F G +I I NP++ G
Sbjct: 251 TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTL 310
Query: 193 --NGAFQ--------GMKKLSYIRIADTNITSIPQ--------------------GLPP- 221
NGA Q G L + + I+S+PQ LP
Sbjct: 311 TLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSF 370
Query: 222 ----------------------------SLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253
SL L+L NKI+ + + L +L KL LS
Sbjct: 371 SVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLS 430
Query: 254 FNSISAVDNGSLANTPHLR 272
N +S+ L HL+
Sbjct: 431 SNLLSSFPITGLHGLTHLK 449
>gi|4826876 osteomodulin [Homo sapiens]
Length = 421
Score = 112 bits (279), Expect = 7e-25
Identities = 83/269 (30%), Positives = 132/269 (49%), Gaps = 16/269 (5%)
Query: 54 CPFRCQCHLRV---VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
C C C + C + L +P ++P L LQ N+I + F N +L +
Sbjct: 62 CVSECFCPTNFPSSMYCDNRKLKTIP-NIPMHIQQLYLQFNEIEAVTANSFINATHLKEI 120
Query: 111 ILVNNKIS--KVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV 168
L +NKI K+ G F L L +L+L N L+E P +PK+L+ L NEI+K++
Sbjct: 121 NLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTN 180
Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHL 228
+GL + +++L N L S +++ F M+KL + + + S+P GLP SL L L
Sbjct: 181 AMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSL 240
Query: 229 DGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTR---VP 285
+ N IS + L L L +S N + + ++ N P++ EL + +NKL + +P
Sbjct: 241 ENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPY-NIFNLPNIVELSVGHNKLKQAFYIP 299
Query: 286 GGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
L EH +YL NN I + + CP
Sbjct: 300 RNL-EH-----LYLQNNEIEKMNLTVMCP 322
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 109 bits (273), Expect = 3e-24
Identities = 65/166 (39%), Positives = 94/166 (56%), Gaps = 7/166 (4%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP +C C V C LGL VP+ +P + LDL N IT I DF LKNL L L
Sbjct: 34 CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM----PKTLQELRAHENEITKVRKVT 169
+N++S + GAF L +LERL L+KN+L+ LPE + PK L L EN+I + +
Sbjct: 94 DNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPK-LTRLDLSENQIQGIPRKA 152
Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSI 215
F G+ + ++L N + S IE+GAF+ ++ L + + + NI+ I
Sbjct: 153 FRGITDVKNLQLDNNHI--SCIEDGAFRALRDLEILTLNNNNISRI 196
Score = 108 bits (269), Expect = 1e-23
Identities = 99/366 (27%), Positives = 160/366 (43%), Gaps = 94/366 (25%)
Query: 53 VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALI 111
VCP +C+C +V CS+ L ++P LP T L L +N+++ ++ G FK L NL +
Sbjct: 504 VCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKIN 563
Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA-------------- 157
L NNKI +V GAF ++ L L+ NQL+ + ++ + L L+
Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623
Query: 158 -------------HENEITKVRKVTFNGLNQMIVIELGTNP------------------- 185
++N IT + F L + I L +NP
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRI 683
Query: 186 ------------LKSSGIENGAFQ-----GMKKLS----------------YIRIADTNI 212
LK I++ A Q G ++ S +R ++ +
Sbjct: 684 VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGL 743
Query: 213 TSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLR 272
++P+G+P +TEL+L+GN ++ V L L +L + LS NSIS + N + +N HL
Sbjct: 744 RALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLS 802
Query: 273 ELHLDNNKLTRVP----GGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVS 328
L L N+L +P GL + ++V+ LH N+IS V P G S S ++
Sbjct: 803 TLILSYNRLRCIPVHAFNGL---RSLRVLTLHGNDISSV------PEGSFNDLTSLSHLA 853
Query: 329 LFSNPV 334
L +NP+
Sbjct: 854 LGTNPL 859
Score = 84.0 bits (206), Expect = 2e-16
Identities = 51/140 (36%), Positives = 78/140 (55%), Gaps = 4/140 (2%)
Query: 50 LGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHA 109
L P CP +C C VV+CS+ GL +P+ +P D T L L+ N +T + + L++L
Sbjct: 721 LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTL 779
Query: 110 LILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA---HENEITKVR 166
+ L NN IS ++ F+ + L L LS N+L+ +P L+ LR H N+I+ V
Sbjct: 780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVP 839
Query: 167 KVTFNGLNQMIVIELGTNPL 186
+ +FN L + + LGTNPL
Sbjct: 840 EGSFNDLTSLSHLALGTNPL 859
Score = 82.4 bits (202), Expect = 6e-16
Identities = 51/168 (30%), Positives = 89/168 (52%), Gaps = 6/168 (3%)
Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
L+ +P +P+ + L N IT++ K+ F GL + V+ L N + S IE GAFQ +K
Sbjct: 52 LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV--SVIERGAFQDLK 109
Query: 201 KLSYIRIADTNITSIPQGL---PPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
+L +R+ + +P+ L P LT L L N+I + + +G+ ++ L L N I
Sbjct: 110 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 169
Query: 258 SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 304
S +++G+ L L L+NN ++R+ H I+ + LH+N++
Sbjct: 170 SCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Score = 74.3 bits (181), Expect = 2e-13
Identities = 71/294 (24%), Positives = 126/294 (42%), Gaps = 30/294 (10%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C C +V C GL ++P +LP + L+ N I I G F K L + +
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
N+IS ++P AF L L L L N++ E+ + + +LQ L + N+I +R TF
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA------DTNITSIPQGLPPSLT 224
L + ++ L N L++ I G F ++ + + +A D ++ + L +
Sbjct: 400 QDLQNLNLLSLYDNKLQT--ISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN-- 455
Query: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLREL---------- 274
+ G + S + K ++ + F + D S ++ +L
Sbjct: 456 PIETSGARCSSPRRLANKRISQIK--SKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEG 513
Query: 275 ---HLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYS 325
N KL R+P L E Y+ + L++N +SV+ ++ N +K + S
Sbjct: 514 TIVDCSNQKLVRIPSHLPE--YVTDLRLNDNEVSVLEATGIFKKLPNLRKINLS 565
Score = 59.7 bits (143), Expect = 4e-09
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 52/263 (19%)
Query: 55 PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLD------LQNNKITEIKDGDFKNLKNLH 108
PF C CHL+ L +D P +T+ L N +I++IK F+ +
Sbjct: 438 PFVCDCHLK-------WLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGS-- 488
Query: 109 ALILVNNKISKVSPGAFTPLVKLER-------LYLSKNQLKELPEKMPKTLQELRAHENE 161
+ S+ S F LV E+ + S +L +P +P+ + +LR ++NE
Sbjct: 489 -----EDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNE 543
Query: 162 ITKVRKV-TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP 220
++ + F L + I L N +K + GAF G
Sbjct: 544 VSVLEATGIFKKLPNLRKINLSNNKIKE--VREGAFDGAA-------------------- 581
Query: 221 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNK 280
S+ EL L GN++ V +GL+ L L L N I V N + A +R L L +N+
Sbjct: 582 -SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNR 640
Query: 281 LTRV-PGGLAEHKYIQVVYLHNN 302
+T + PG + + L +N
Sbjct: 641 ITTITPGAFTTLVSLSTINLLSN 663
Score = 48.5 bits (114), Expect = 9e-06
Identities = 60/242 (24%), Positives = 101/242 (41%), Gaps = 11/242 (4%)
Query: 82 DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQL 141
D L L NN I+ I+DG F+ L++L L L NN IS++ +F + K+ L L N L
Sbjct: 158 DVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Query: 142 --KELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELG-TNPLKSSGIENGAFQG 198
+ L++ R + V G N V + P S +
Sbjct: 218 YCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANS 277
Query: 199 MKKLSYIRIADTNITSIPQGL---PPSLTE----LHLDGNKISRVDAASLKGLNNLAKLG 251
+ S ++ + +GL P +L E + L+ N I + A + L ++
Sbjct: 278 ISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRID 337
Query: 252 LSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLHNNNISVVGSS 310
+S N IS + + L L L NK+T + GL + +Q++ L+ N I+ + +
Sbjct: 338 ISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVN 397
Query: 311 DF 312
F
Sbjct: 398 TF 399
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 109 bits (273), Expect = 3e-24
Identities = 78/256 (30%), Positives = 122/256 (47%), Gaps = 9/256 (3%)
Query: 54 CPFRCQCHLRV--VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
CP C C + V C+ L +VP +P +T L+LQ N I I+ FK+L++L L
Sbjct: 57 CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116
Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELR---AHENEITKVRKV 168
L N + K+ GAF L L L L N+L +P + + L +LR N I +
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQ-GLPPSLTELH 227
FN + + ++LG + I AF+G+ L Y+ + N+ IP L EL
Sbjct: 177 AFNRVPSLRRLDLG-ELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELE 235
Query: 228 LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGG 287
L GN++ + S +GL +L KL L ++ ++ + + L EL+L +N L +P
Sbjct: 236 LSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHD 295
Query: 288 LAE--HKYIQVVYLHN 301
L H+ +V HN
Sbjct: 296 LFTPLHRLERVHLNHN 311
Score = 37.7 bits (86), Expect = 0.016
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 9/95 (9%)
Query: 100 DFKNLKNLHALI------LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PK 150
+ K++ NL AL+ L N++ + PG+F L L +L+L Q+ + K
Sbjct: 218 NLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLK 277
Query: 151 TLQELRAHENEITKVRKVTFNGLNQMIVIELGTNP 185
+L+EL N + + F L+++ + L NP
Sbjct: 278 SLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNP 312
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 109 bits (272), Expect = 4e-24
Identities = 63/166 (37%), Positives = 89/166 (53%), Gaps = 5/166 (3%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C C V C GL +PK++P +T L+L N IT I DF LK L L L+
Sbjct: 34 CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLM 93
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
N+I V GAF + +LERL L++NQL LPE + + L L EN I + + F
Sbjct: 94 ENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAF 153
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP 216
G + ++L N + S IE GAF+ ++ L + + + NIT+IP
Sbjct: 154 RGATDLKNLQLDKNQI--SCIEEGAFRALRGLEVLTLNNNNITTIP 197
Score = 109 bits (272), Expect = 4e-24
Identities = 84/295 (28%), Positives = 133/295 (45%), Gaps = 37/295 (12%)
Query: 53 VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALI 111
VCP +C+C VV+CS L L K+P+ +P T L L NN+I+ ++ G FK L +L +
Sbjct: 512 VCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571
Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA---HENEITKVRKV 168
L NNK+S++ GAF + L+L+ NQL+ + M + L LR N I+ +
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631
Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTN----------------- 211
+F GL + ++ L N + + + GAF ++ LS + +
Sbjct: 632 SFTGLRNVRLLSLYDNQITT--VSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKR 689
Query: 212 --ITSIPQGLPPS-LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANT 268
+T P+ P L ++ L + + +D +
Sbjct: 690 KIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN 749
Query: 269 PHLR-----------ELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
HLR EL+LD N+ T VPG L+ KY+Q+V L NN IS + +S F
Sbjct: 750 KHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSF 804
Score = 103 bits (257), Expect = 2e-22
Identities = 96/395 (24%), Positives = 159/395 (40%), Gaps = 101/395 (25%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTT------------------------LLDLQ 89
CP C C +V C GL +P +LP T +DL
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
Query: 90 NNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMP 149
NN+I EI F+ L++L++L+L NKI+ + G F L L+ L L+ N++ +
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 150 KTLQELRA---HENEITKVRKVTFNGLNQMIVIELG------------------TNPLKS 188
+ LQ L ++N+I + K TF L + + L TNP+++
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461
Query: 189 SG----------------IENGAFQGMKKLSY---------------------------- 204
SG I++ F+ K Y
Sbjct: 462 SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEA 521
Query: 205 --IRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASL-KGLNNLAKLGLSFNSISAVD 261
+ + +T IP+ +P S EL L+ N+IS ++A + K L +L K+ LS N +S ++
Sbjct: 522 NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIE 581
Query: 262 NGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDFCPPGHNTK 320
+G+ + ELHL N+L + G+ ++ + L NN IS + + F T
Sbjct: 582 DGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF------TG 635
Query: 321 KASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
+ +SL+ N Q + P F + S + L
Sbjct: 636 LRNVRLLSLYDN--QITTVSPGAFDTLQSLSTLNL 668
Score = 75.9 bits (185), Expect = 5e-14
Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 4/138 (2%)
Query: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
P CP C C VV+CS+ L +PK +P + T L L N+ T + G K L +
Sbjct: 732 PQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVD 790
Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELR---AHENEITKVRKV 168
L NNKIS +S +FT + +L L LS N L+ +P + L+ LR H N+I+ +++
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850
Query: 169 TFNGLNQMIVIELGTNPL 186
F + + + +G NPL
Sbjct: 851 IFADVTSLSHLAIGANPL 868
Score = 72.0 bits (175), Expect = 8e-13
Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 24/173 (13%)
Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
L+ +P+ +P+ + L + N IT++ K F GL Q+ V++L N + +E GAF MK
Sbjct: 52 LQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI--GAVERGAFDDMK 109
Query: 201 KLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 260
+L +R+ + +P EL N+ L++L LS N+I A+
Sbjct: 110 ELERLRLNRNQLHMLP--------ELLFQNNQA-------------LSRLDLSENAIQAI 148
Query: 261 DNGSLANTPHLRELHLDNNKLTRV-PGGLAEHKYIQVVYLHNNNISVVGSSDF 312
+ L+ L LD N+++ + G + ++V+ L+NNNI+ + S F
Sbjct: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF 201
Score = 66.2 bits (160), Expect = 4e-11
Identities = 75/291 (25%), Positives = 118/291 (40%), Gaps = 51/291 (17%)
Query: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELP 145
LDL N I I F+ +L L L N+IS + GAF L LE L L+ N + +P
Sbjct: 138 LDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIP 197
Query: 146 ----EKMPKTLQELRAHENEI------------TKVR-----------KVTFNGLNQMIV 178
MPK L+ R H N + + R + GLN V
Sbjct: 198 VSSFNHMPK-LRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLN---V 253
Query: 179 IELGTNPLKSSG-----------IENGAFQGMKKLS--YIRIADTNITSIPQGLPPSLTE 225
E+ + SG + +G+ M S + +T+IP LP ++TE
Sbjct: 254 AEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
Query: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
+ L+ N I + + L ++ LS N I+ + + L L L NK+T +P
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
Query: 286 GGLAEHKY-IQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQ 335
G+ Y +Q++ L+ N I+ + F + S +SL+ N +Q
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAF------QDLQNLSLLSLYDNKIQ 418
Score = 50.8 bits (120), Expect = 2e-06
Identities = 26/76 (34%), Positives = 40/76 (52%)
Query: 210 TNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 269
T + +IP+ +P + L L+GN I+R+ GL L L L N I AV+ G+ +
Sbjct: 50 TGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMK 109
Query: 270 HLRELHLDNNKLTRVP 285
L L L+ N+L +P
Sbjct: 110 ELERLRLNRNQLHMLP 125
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 105 bits (262), Expect = 6e-23
Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 95/383 (24%)
Query: 40 VPDDRDFEPSLGP------VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKI 93
+P D+ L CP +C+C V CS+ L+K+P+ +P T L L NN+
Sbjct: 486 IPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEF 545
Query: 94 TEIK-DGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL 152
T ++ G FK L L + NNKI+ + GAF + + L+ N+L+ + KM K L
Sbjct: 546 TVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGL 605
Query: 153 QELRA---------------------------HENEITKVRKVTFNGLNQMIVIELGTNP 185
+ L+ ++N+IT V F+ L+ + + L NP
Sbjct: 606 ESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANP 665
Query: 186 -------------------------------LKSSGIENGAFQGM-----------KKLS 203
LK I++ A Q LS
Sbjct: 666 FNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLS 725
Query: 204 -----------YIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGL 252
+R ++ + +P+G+P +TEL+LDGN+ + V L +L + L
Sbjct: 726 RCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDL 784
Query: 253 SFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSD 311
S N IS + N S +N L L L N+L +P + K ++++ LH N+ISVV
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV---- 840
Query: 312 FCPPGHNTKKASYSGVSLFSNPV 334
P G ++ S +++ +NP+
Sbjct: 841 --PEGAFNDLSALSHLAIGANPL 861
Score = 104 bits (260), Expect = 1e-22
Identities = 61/165 (36%), Positives = 90/165 (54%), Gaps = 5/165 (3%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP +C C V C L L VP+++P +T LDL N IT I DF L++L L L+
Sbjct: 28 CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLM 87
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
NKIS + GAF L +LERL L++N L+ PE + L L EN+I + + F
Sbjct: 88 ENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAF 147
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSI 215
G + ++L N + S IE+GAF+ ++ L + + + NIT +
Sbjct: 148 RGAVDIKNLQLDYNQI--SCIEDGAFRALRDLEVLTLNNNNITRL 190
Score = 82.8 bits (203), Expect = 4e-16
Identities = 51/168 (30%), Positives = 87/168 (51%), Gaps = 6/168 (3%)
Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
L+ +P +P+ + L + N IT++ K F GL + V++L N K S IE GAFQ +K
Sbjct: 46 LRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMEN--KISTIERGAFQDLK 103
Query: 201 KLSYIRIADTNITSIPQGL---PPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
+L +R+ ++ P+ L L L L N+I + + +G ++ L L +N I
Sbjct: 104 ELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQI 163
Query: 258 SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 304
S +++G+ L L L+NN +TR+ H ++ LH+NN+
Sbjct: 164 SCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Score = 82.4 bits (202), Expect = 6e-16
Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 5/158 (3%)
Query: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
CP C C +V C GL ++P +LP T + L+ N I I G F K L + L
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332
Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRKVTF 170
NN+IS+++P AF L L L L N++ ELP+ + + +LQ L + N+I +R F
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392
Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
L+ + ++ L N L++ I G F ++ + + +A
Sbjct: 393 QDLHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMHLA 428
Score = 67.0 bits (162), Expect = 2e-11
Identities = 68/295 (23%), Positives = 128/295 (43%), Gaps = 33/295 (11%)
Query: 85 LLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKN----- 139
LL L NKI ++ F++L NL+ L L +NK+ ++ G F+PL ++ ++L++N
Sbjct: 376 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD 435
Query: 140 -QLKELPEKM---------PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
LK L + + + R I +++ F + GT +S
Sbjct: 436 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK 495
Query: 190 GIENGAFQGMKKLSYIRIADTNI-------TSIPQGLPPSLTELHLDGNKISRVDAASL- 241
+ F + R T + IP+ +P EL L+ N+ + ++A +
Sbjct: 496 -LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIF 554
Query: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLH 300
K L L K+ S N I+ ++ G+ + E+ L +N+L V + + + ++ + L
Sbjct: 555 KKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLR 614
Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
+N I+ VG+ F +S +SL+ N Q + P F ++ S + L
Sbjct: 615 SNRITCVGNDSF------IGLSSVRLLSLYDN--QITTVAPGAFDTLHSLSTLNL 661
Score = 67.0 bits (162), Expect = 2e-11
Identities = 66/242 (27%), Positives = 101/242 (41%), Gaps = 33/242 (13%)
Query: 55 PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFK-NLKNLHALILV 113
PF C CHL+ + L + + T+ L N +I +IK F+ + K + +
Sbjct: 431 PFICDCHLKWL-ADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT 489
Query: 114 NNKISKVSPGAFTPLVKLER-------LYLSKNQLKELPEKMPKTLQELRAHENEITKVR 166
+ SK+S F L E+ + S +L ++PE +P+ ELR + NE T +
Sbjct: 490 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE 549
Query: 167 KV-TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE 225
F L Q+ I N K + IE GAF+G + E
Sbjct: 550 ATGIFKKLPQLRKINFSNN--KITDIEEGAFEGAS---------------------GVNE 586
Query: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
+ L N++ V KGL +L L L N I+ V N S +R L L +N++T V
Sbjct: 587 ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 646
Query: 286 GG 287
G
Sbjct: 647 PG 648
Score = 64.3 bits (155), Expect = 2e-10
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 26/242 (10%)
Query: 82 DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQL 141
D L L N+I+ I+DG F+ L++L L L NN I+++S +F + KL L N L
Sbjct: 152 DIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Query: 142 ---------KELPEKMPKT--------LQELRAHENEITKVRKVTFNGLNQMIVIELGTN 184
+ + P+ LR H + R+ +G +
Sbjct: 212 YCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMA------ 265
Query: 185 PLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGL 244
S + + + + +T IP LP ++TE+ L+ N I + +
Sbjct: 266 --PSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPY 323
Query: 245 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLHNNN 303
L ++ LS N IS + + L L L NK+T +P L E + +Q++ L+ N
Sbjct: 324 KKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANK 383
Query: 304 IS 305
I+
Sbjct: 384 IN 385
Score = 52.8 bits (125), Expect = 5e-07
Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 24/163 (14%)
Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
L E+P +P+T+ E+R +N I + F+ ++ I+L N + S + AFQG++
Sbjct: 291 LTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI--SELAPDAFQGLR 348
Query: 201 KLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 260
SL L L GNKI+ + + +GL +L L L+ N I+ +
Sbjct: 349 ---------------------SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL 387
Query: 261 DNGSLANTPHLRELHLDNNKL-TRVPGGLAEHKYIQVVYLHNN 302
+ + +L L L +NKL T G + + IQ ++L N
Sbjct: 388 RVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,226,895
Number of Sequences: 37866
Number of extensions: 644396
Number of successful extensions: 4370
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 1812
Number of HSP's gapped (non-prelim): 1123
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.