Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 4502175

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502175 apical protein of Xenopus-like [Homo sapiens]
         (1616 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502175 apical protein of Xenopus-like [Homo sapiens]             3285   0.0  
gi|203098098 shroom family member 3 protein [Homo sapiens]            415   e-115
gi|118600967 shroom family member 4 [Homo sapiens]                    250   9e-66
gi|31442420 shroom family member 1 [Homo sapiens]                     117   7e-26
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...    63   3e-09
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...    63   3e-09
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         61   8e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        60   2e-08
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                   60   2e-08
gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                   60   2e-08
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                   60   2e-08
gi|13994151 PDZ and LIM domain 1 [Homo sapiens]                        57   2e-07
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]     56   2e-07
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]     56   2e-07
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]              55   7e-07
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                   54   9e-07
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]              54   1e-06
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]              54   1e-06
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]             54   1e-06
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]             54   1e-06
gi|145199237 transcription elongation factor B polypeptide 3 bin...    54   1e-06
gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]             54   2e-06
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]              54   2e-06
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                    53   3e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    52   4e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    52   5e-06
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]              52   5e-06
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]              52   5e-06
gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]              52   5e-06
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          52   6e-06

>gi|4502175 apical protein of Xenopus-like [Homo sapiens]
          Length = 1616

 Score = 3285 bits (8517), Expect = 0.0
 Identities = 1616/1616 (100%), Positives = 1616/1616 (100%)

Query: 1    MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS 60
            MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS
Sbjct: 1    MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS 60

Query: 61   KAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHAT 120
            KAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHAT
Sbjct: 61   KAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHAT 120

Query: 121  KFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDS 180
            KFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDS
Sbjct: 121  KFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDS 180

Query: 181  LDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVG 240
            LDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVG
Sbjct: 181  LDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVG 240

Query: 241  LWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGP 300
            LWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGP
Sbjct: 241  LWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGP 300

Query: 301  VWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGD 360
            VWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGD
Sbjct: 301  VWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGD 360

Query: 361  RRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFP 420
            RRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFP
Sbjct: 361  RRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFP 420

Query: 421  QSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPC 480
            QSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPC
Sbjct: 421  QSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPC 480

Query: 481  VQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDK 540
            VQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDK
Sbjct: 481  VQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDK 540

Query: 541  GAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPES 600
            GAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPES
Sbjct: 541  GAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPES 600

Query: 601  SPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGT 660
            SPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGT
Sbjct: 601  SPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGT 660

Query: 661  GRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGD 720
            GRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGD
Sbjct: 661  GRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGD 720

Query: 721  PDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSP 780
            PDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSP
Sbjct: 721  PDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSP 780

Query: 781  HQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTE 840
            HQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTE
Sbjct: 781  HQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTE 840

Query: 841  PWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADD 900
            PWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADD
Sbjct: 841  PWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADD 900

Query: 901  ILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQ 960
            ILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQ
Sbjct: 901  ILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQ 960

Query: 961  STPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYR 1020
            STPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYR
Sbjct: 961  STPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYR 1020

Query: 1021 YSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDG 1080
            YSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDG
Sbjct: 1021 YSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDG 1080

Query: 1081 APADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVS 1140
            APADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVS
Sbjct: 1081 APADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVS 1140

Query: 1141 GDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERV 1200
            GDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERV
Sbjct: 1141 GDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERV 1200

Query: 1201 MDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRF 1260
            MDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRF
Sbjct: 1201 MDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRF 1260

Query: 1261 CLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELA 1320
            CLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELA
Sbjct: 1261 CLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELA 1320

Query: 1321 REIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEER 1380
            REIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEER
Sbjct: 1321 REIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEER 1380

Query: 1381 KEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQEL 1440
            KEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQEL
Sbjct: 1381 KEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQEL 1440

Query: 1441 IESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVN 1500
            IESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVN
Sbjct: 1441 IESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVN 1500

Query: 1501 LLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVF 1560
            LLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVF
Sbjct: 1501 LLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVF 1560

Query: 1561 DILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK 1616
            DILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK
Sbjct: 1561 DILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK 1616


>gi|203098098 shroom family member 3 protein [Homo sapiens]
          Length = 1996

 Score =  415 bits (1067), Expect = e-115
 Identities = 379/1143 (33%), Positives = 517/1143 (45%), Gaps = 240/1143 (20%)

Query: 639  AKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQ---EGPLAGTYKDHLKEAQARVLRAT 695
            A+L +S+ST  L++  E E     WR   G       + P +  Y++ +K+AQ+RVL AT
Sbjct: 883  ARLLRSQSTFQLSSEPEREP---EWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGAT 939

Query: 696  SFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRI------- 748
            SF+RRDL+          +  R   P   P     GL  P +S S  PH PR        
Sbjct: 940  SFRRRDLELGA------PVASRSWRPR--PSSAHVGLRSPEASASASPHTPRERHSVTPA 991

Query: 749  --------------GGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSP------HQHPRTSE 788
                          G RRR T EQK +SYSEPEKMNEVG+     P          R  E
Sbjct: 992  EGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPE 1051

Query: 789  DTVGTFADRWKFFEETSKPVPQ--------RPAQKQALHGIPRDKPERPRTAGRTCEGTE 840
             +V   ADR + FE   K            +  Q+ AL    + K  +  T+   C   E
Sbjct: 1052 SSV---ADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQE 1108

Query: 841  PW-----SRTTSLGDSLNAHSAAEKAGTSDL---------PRRLGTF-----AEYQASWK 881
            P      +++  L     A   +  A  S L         PRR  T      AE Q + +
Sbjct: 1109 PGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPR 1168

Query: 882  EQRK---------------------------------PLEARS----SGRCHSADDILDV 904
            ++                                   P E  S    +G+  SA+D+L+ 
Sbjct: 1169 DRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLER 1228

Query: 905  SLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAG-----DP----GEPREELPSAVR 955
            S D    P HV  RSRSSP+T   +Q+  V L + +G     DP    G     L  + R
Sbjct: 1229 S-DVLAGPVHV--RSRSSPATADKRQD--VLLGQDSGFGLVKDPCYLAGPGSRSLSCSER 1283

Query: 956  AEEGQS------TPRQADAQCRE-----------GSPGSQQHPPSQKAPNPP---TFSEL 995
             +E         TPR   + C+            G+   Q+       P PP   T   +
Sbjct: 1284 GQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLV 1343

Query: 996  SHCRGAPELPREGRGRAGTLPRDYRYSEEST---------PADL------------GPRA 1034
            +  R AP  P  G      +P  Y   +  T         PA +            GPR 
Sbjct: 1344 TDTRAAPLTPI-GTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRG 1402

Query: 1035 QSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPF 1094
                 P H        V      +   PQ PPP + +       D  P ++         
Sbjct: 1403 CEGDGPEHG-------VEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSA------- 1448

Query: 1095 PTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALL-- 1152
              P  A+L  Y  + SL   PS+ S++ P DTP       G+    G  S  + E++L  
Sbjct: 1449 --PDFANLKHYQKQQSL---PSLCSTSDP-DTPL------GAPSTPGRISLRISESVLRD 1496

Query: 1153 -PPKQQHLRLQT--------ATMETSRSPSPQFAPQKLTDKPPLLIQDE-----DSTRIE 1198
             PP  +    +         AT   +  P P   P   + + P+   D+       T  E
Sbjct: 1497 SPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCE 1556

Query: 1199 RVMDN----------NTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIK 1248
              +D+          N   K+   +  H          Q+LA   +        E     
Sbjct: 1557 AQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPS 1616

Query: 1249 TLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKE 1308
             +S   Q           G +P AP + Q     P+      EK     P         +
Sbjct: 1617 FMSVHAQLAGSL------GGQP-APIQTQSLSHDPVSGTQGLEKKVSPDP---------Q 1660

Query: 1309 KTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLL 1368
            K+ ED+++E LA+EIV +DKSLADILDP  ++KTTMDLMEG+FP+D +LL+E   +RK +
Sbjct: 1661 KSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAI 1720

Query: 1369 PKIPSPRSTEERKEEPSVPAAVSLATNS-TYYSTSAPKAELLIKMKDLQEQQEHEEDSGS 1427
             +  S    E ++ E     AVS+  N   YYS SAPKAELL K+K++  +   EE+   
Sbjct: 1721 QRTVSSSGCEGKRNEDK--EAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQA- 1777

Query: 1428 DLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDK 1487
                D++ KK ELI S++ KL+ L+EA+ SLL D++ N  LG EVEA++  +CKP+EFDK
Sbjct: 1778 ----DVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDK 1833

Query: 1488 FRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKE 1547
            +RMFIGDLDKVVNLLLSLSGRLARVEN L+ L + AS  +R SL EK+++L  QHEDA+E
Sbjct: 1834 YRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARE 1893

Query: 1548 LKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLL 1607
            LKENLDRRER+V  ILANYLSEE L DY+HFVKMKS L+IEQR+L+DKI LG+EQ+KCLL
Sbjct: 1894 LKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLL 1953

Query: 1608 DSL 1610
            +SL
Sbjct: 1954 ESL 1956



 Score =  186 bits (473), Expect = 1e-46
 Identities = 148/406 (36%), Positives = 190/406 (46%), Gaps = 103/406 (25%)

Query: 14  AEAETRAADGGRLV--EVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAV-DKLLA 70
           A   +  A  GR +  E  L GGAPWGFTLKGG EHGEPL+I+K+EEG KA  +  KL A
Sbjct: 13  ATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQA 72

Query: 71  GDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVK------------------------- 105
           GDE+V IN++ LS  R+EA+ LVKGS+KTL+LVV+                         
Sbjct: 73  GDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTS 132

Query: 106 -------------------RRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGR 146
                              RRSE   RPHSWH TK  +  P+ +    +     P W   
Sbjct: 133 GPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQS 192

Query: 147 HHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLD----HPSSRLSVAKSNSSIDHLGS 202
           +H+SSS+ DL S+++   L+R+ D  SS GS++SL+    +P   LS AKS  SID L  
Sbjct: 193 YHSSSSTSDL-SNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSH 251

Query: 203 -HSKRDSAYGSFSTSSST---PDHTLSKADTS-SAENILYTVGLWEAPRQG--------- 248
            H+KRDSAY SFSTSSS    P   +S  + S S +N     GL E  RQ          
Sbjct: 252 FHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY 311

Query: 249 --------------------GRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEP 288
                               GR+A+A+ + QG  +K S  P       GKG  P      
Sbjct: 312 DTRRGVSAEYEVNSSALLLQGREARASANGQG-YDKWSNIP------RGKGVPP------ 358

Query: 289 KLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEK 334
               P  S   P          P     P PP RSDS+AA +  E+
Sbjct: 359 ----PSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRER 400



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 42/166 (25%), Positives = 58/166 (34%), Gaps = 41/166 (24%)

Query: 311  PSSPPPPPPPLRS------DSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPE 364
            P  PPPPPPP +       D F     H   +  + SE              P G R   
Sbjct: 1525 PLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSE-------------DPEGPR--- 1568

Query: 365  LTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPH 424
                 +      ++ +    PG    AH  GS        +SRLQ S+  S+        
Sbjct: 1569 ---PSFNKLSKVTIARERHMPGA---AHVVGS-----QTLASRLQTSIKGSEA------- 1610

Query: 425  SGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKL 470
                P   S H+ L A SLG +P     Q+ S   V G    ++K+
Sbjct: 1611 ESTPPSFMSVHAQL-AGSLGGQPAPIQTQSLSHDPVSGTQGLEKKV 1655


>gi|118600967 shroom family member 4 [Homo sapiens]
          Length = 1493

 Score =  250 bits (638), Expect = 9e-66
 Identities = 139/245 (56%), Positives = 179/245 (73%), Gaps = 17/245 (6%)

Query: 1376 STEERKEE----------PSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDS 1425
            +TE  K+E          P +P + S      YY+ S  KAELL K+KD  E  E     
Sbjct: 1249 ATESAKQEFQHFSPPSGAPGIPTSYS-----AYYNISVAKAELLNKLKDQPEMAEIGLGE 1303

Query: 1426 GSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEF 1485
              ++DH+L+ KK +LIESISRKL VLREA+  LLED+ AN+ LG EVEA +K VCK +EF
Sbjct: 1304 -EEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEF 1362

Query: 1486 DKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDA 1545
            +K+ +F+GDLDKVVNLLLSLSGRLARVENALN++D  A+  ++  L+EK++ L  Q  DA
Sbjct: 1363 EKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQ-EKLVLIEKKQQLTGQLADA 1421

Query: 1546 KELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKC 1605
            KELKE++DRRE++VF +++ YL ++ L DY+HFVKMKSALIIEQRELE+KI LGEEQLKC
Sbjct: 1422 KELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKC 1481

Query: 1606 LLDSL 1610
            L +SL
Sbjct: 1482 LRESL 1486



 Score =  192 bits (489), Expect = 2e-48
 Identities = 191/644 (29%), Positives = 280/644 (43%), Gaps = 64/644 (9%)

Query: 27  VEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFR 86
           V VQL GGAPWGFTLKGG EH EPL ++KIE+G KAA   K+  GDE+V IN   L G R
Sbjct: 11  VPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYGSR 70

Query: 87  QEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAAS-PFTSTSGCPSWSG 145
           QEA+ L+KGS + LKL+V+RR+    RPHSWH  K  +  PE A +  F S +   SW  
Sbjct: 71  QEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFPSEAFSLSW-- 128

Query: 146 RHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSK 205
             H+  ++ D+   W   +   + +  SS+GS++SL+ P  + +       ID     ++
Sbjct: 129 --HSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQP-GQATYESHLLPIDQNMYPNQ 185

Query: 206 RDSAYGSFSTSSSTPDHTLS--KADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEE 263
           RDSAY SFS SS+  D  LS    + +S + I+   G  +AP   GR   A  +  G   
Sbjct: 186 RDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAP--SGRPNVA--ETSGGSR 241

Query: 264 KLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRS 323
           + +             P+  Y + P  A  G                     PP PP+R 
Sbjct: 242 RTNGGHLTPSSQMSSRPQEGYQSGPAKAVRG---------------------PPQPPVRR 280

Query: 324 DSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSG 383
           DS  A+    +AQ     +  A++    L Q + +    P L  R     +P      SG
Sbjct: 281 DSLQAS----RAQLLNGEQRRASEPVVPLPQKE-KLSLEPVLPAR-----NPNRFCCLSG 330

Query: 384 GPGCPQEAHADGSW---PPSKDGASSRLQASLSSSDVRFPQS---PHSGRHPPLYSDHSP 437
                 E H +  +   P S    S  L    S+  V  P++     S    PL    + 
Sbjct: 331 HDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVGSPKACDRASSVDSNPLNEASAE 390

Query: 438 LCADSLGQEP---GAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGC 494
           L   S G+ P   G    ++ +P Q+  L+S  Q +    +G +      +Q    W   
Sbjct: 391 LAKASFGRPPHLIGPTGHRHSAPEQL--LASHLQHVHLDTRGSKGMELPPVQDGHQWT-L 447

Query: 495 WPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDAR-----ETGRCYPLDKGAEG--CSA 547
            P  ++    +S  PPT G   +    +     D R        +  P    A+G     
Sbjct: 448 SPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLGHQSQSSPPHGEADGHPSEK 507

Query: 548 GAQEPPRASRA--EKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDS 605
           G  +P R SRA  E A+Q+ +AS +     +      +        +EG   P+      
Sbjct: 508 GFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAASGTEAGEEGDSEPKECSRMG 567

Query: 606 ATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVA 649
             R         +  R+S+RFAT LRNEIQ  +A+LQKS+  ++
Sbjct: 568 GRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLS 611


>gi|31442420 shroom family member 1 [Homo sapiens]
          Length = 847

 Score =  117 bits (294), Expect = 7e-26
 Identities = 94/301 (31%), Positives = 150/301 (49%), Gaps = 31/301 (10%)

Query: 1317 EELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRS 1376
            EEL +E+   D SL D L      +  + L++G+ P        A+ R  + P      +
Sbjct: 543  EELVQELARLDPSLCDPLASQPSPEPPLGLLDGLIPL-------AEVRAAMRP------A 589

Query: 1377 TEERKEEPSVPAAVSLATNSTYYSTS----APKAELLIKMKDLQEQQEHEEDSGSDL--- 1429
              E  EE    AA +    S  +S +    AP+ E   ++++       ++  G  L   
Sbjct: 590  CGEAGEE----AASTFEPGSYQFSFTQLLPAPREET--RLENPATHPVLDQPCGQGLPAP 643

Query: 1430 DHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFR 1489
            ++ +  KK EL   + + LQ L   +E L  + QA     A +EA V+  C P E ++F 
Sbjct: 644  NNSIQGKKVELAARLQKMLQDLHTEQERLQGEAQAWARRQAALEAAVRQACAPQELERFS 703

Query: 1490 MFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELK 1549
             F+ DL++V+ LLL L  RLARV  AL      + P +     ++ R+L +Q EDAKELK
Sbjct: 704  RFMADLERVLGLLLLLGSRLARVRRALARAASDSDPDE-----QRLRLLQRQEEDAKELK 758

Query: 1550 ENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDS 1609
            E++ RRER V ++L   L  E L  Y   +  K+A++ +QR L+++I L ++QL  + D 
Sbjct: 759  EHVARRERAVREVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDD 818

Query: 1610 L 1610
            L
Sbjct: 819  L 819



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 110/477 (23%), Positives = 164/477 (34%), Gaps = 100/477 (20%)

Query: 178 VDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENI-- 235
           +++L     R S A S SS+D      + DSAY SFS +S  P+       T     +  
Sbjct: 1   MEALGPGGDRASPASSTSSLDLWHLSMRADSAYSSFSAASGGPEPRTQSPGTDLLPYLDW 60

Query: 236 LYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGR 295
            Y   +W  P      A     P+          PR    +  GP+P     P    P  
Sbjct: 61  DYVRVVWGGPGPAPPDAALCTSPR----------PRPAVAARSGPQP--TEVPGTPGPLN 108

Query: 296 SNFGPVWY--VPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQ---HFT 350
               P+ Y    + + A  +  PP PP  +   A  +  + AQ  V  E +  +     +
Sbjct: 109 RQATPLLYALAAEAEAAAQAVEPPSPP--ASRAAYRQRLQGAQRRVLRETSFQRKELRMS 166

Query: 351 ALAQAQPRGDRRPELT-DRPWRSAHPGSLGK-------GSGGPGCPQEAHADGSWPPSKD 402
             A+ +P    RP  T  R    +HPG  G+         G  G    A+    W  S+ 
Sbjct: 167 LPARLRPTVPARPPATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQRKWCFSEP 226

Query: 403 GASSR-----------LQASLSSSDVRFPQSPHSGRHPPL--YSDH------SPLCADSL 443
           G   R           L  + SSS +  P+ P   +HP L  + DH            S+
Sbjct: 227 GKLDRVGRGGGPARECLGEACSSSGLPGPE-PLEFQHPALAKFEDHEVGWLPETQPQGSM 285

Query: 444 GQEPGAASFQNDSPPQVRGLSSCDQKLGS--GWQGPRPCVQGDLQAAQLWAGCWPSDTAL 501
             + G+    +   P  R  S+  + LGS  G  G  P VQ   Q A+            
Sbjct: 286 NLDSGSLKLGDAFRPASRSRSASGEVLGSWGGSGGTIPIVQAVPQGAE------------ 333

Query: 502 GALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKA 561
                 P P         LPQ       +E    YP             E P++S A+ +
Sbjct: 334 -----TPRPLFQTKLSRFLPQ-------KEAAVMYP------------AELPQSSPAD-S 368

Query: 562 SQRLAASI---TWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAH 615
            QR++ +     W       +  +E PL+         R  S P+  A++ PP   H
Sbjct: 369 EQRVSETCIVPAWLPSLPDEVFLEEAPLV---------RMRSPPDPHASQGPPASVH 416



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 11/105 (10%)

Query: 680 YKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQP---- 735
           Y+  L+ AQ RVLR TSF+R++L  +     P  L   +       H   A L+ P    
Sbjct: 141 YRQRLQGAQRRVLRETSFQRKELRMS----LPARLRPTVPARPPATHPRSASLSHPGGEG 196

Query: 736 PSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSP 780
             + S  P  P   GR     +Q+   +SEP K++ VG  RG  P
Sbjct: 197 EPARSRAP-APGTAGRGPLANQQRKWCFSEPGKLDRVG--RGGGP 238


>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 115/528 (21%), Positives = 189/528 (35%), Gaps = 91/528 (17%)

Query: 939  QAGDPGEPREEL-PSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSH 997
            Q   P +PR+   PS  +     ++  Q+ A  R G P +  +P   +    P+      
Sbjct: 40   QMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPG-PAAHVYPAGSQVMMIPSQISYPA 98

Query: 998  CRGAPELPREGRGRAGTLPRDY-------RYSEESTPADLGPRAQSPGSPLHARGQDSWP 1050
             +GA  +P +GR       + Y        +   ++P + G  A   G+   A+G   +P
Sbjct: 99   SQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYA---GAYYPAQGVQQFP 155

Query: 1051 VSSALLSKRPAP---QRPP--PPKREPRRYRATD----GAPADAPVGVLGRPFPTPSPAS 1101
               A     PAP    +PP   PKRE +  R  D    G      +    R   TP+P  
Sbjct: 156  TGVA-----PAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQ 210

Query: 1102 LDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRL 1161
                +   +   +P V    +P D  +  +           A RP    L  P+      
Sbjct: 211  TGGGLEPQANGETPQVAVIVRPDDRSQGAII----------ADRP---GLPGPEHSPSES 257

Query: 1162 QTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVK------------- 1208
            Q ++   + SPSP   P    +   L I  +  T I+  ++ +T +              
Sbjct: 258  QPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEP 317

Query: 1209 ------MVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCL 1262
                  ++ +++  S+  PE E   S    A  P   H +E  +   +  SE       L
Sbjct: 318  TPLAEPILEVEVTLSKPVPESEFSSS-PLQAPTPLASHTVEIHEPNGMVPSED------L 370

Query: 1263 YTRQGAEPE-APHRAQPAE-PQPLGTQVPPEK--DRCTSPPGLSYMKAKEKTVEDLKSEE 1318
                 + PE AP  A P+E P P+     PE+  +   SPP +      E        EE
Sbjct: 371  EPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE-------PEE 423

Query: 1319 LAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRK----LLPKIPSP 1374
             A+E+       A +  P++   T         P  E  +EE ++  +       +  S 
Sbjct: 424  QAKEVT------ASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 477

Query: 1375 RSTEERKEEPSVPAAVSLATN-----STYYSTSAPKAELLIKMKDLQE 1417
            +  EE     S P   +L+ N     +T  + S PK    IK  + +E
Sbjct: 478  KGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 525



 Score = 31.2 bits (69), Expect = 8.5
 Identities = 15/40 (37%), Positives = 24/40 (60%), Gaps = 2/40 (5%)

Query: 363 PELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKD 402
           PE+ ++P   ++PG   +GSG P  P+E  AD +W   +D
Sbjct: 542 PEVENQPPAGSNPGPESEGSGVPPRPEE--ADETWDSKED 579


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 115/528 (21%), Positives = 189/528 (35%), Gaps = 91/528 (17%)

Query: 939  QAGDPGEPREEL-PSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSH 997
            Q   P +PR+   PS  +     ++  Q+ A  R G P +  +P   +    P+      
Sbjct: 40   QMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPG-PAAHVYPAGSQVMMIPSQISYPA 98

Query: 998  CRGAPELPREGRGRAGTLPRDY-------RYSEESTPADLGPRAQSPGSPLHARGQDSWP 1050
             +GA  +P +GR       + Y        +   ++P + G  A   G+   A+G   +P
Sbjct: 99   SQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYA---GAYYPAQGVQQFP 155

Query: 1051 VSSALLSKRPAP---QRPP--PPKREPRRYRATD----GAPADAPVGVLGRPFPTPSPAS 1101
               A     PAP    +PP   PKRE +  R  D    G      +    R   TP+P  
Sbjct: 156  TGVA-----PAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQ 210

Query: 1102 LDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRL 1161
                +   +   +P V    +P D  +  +           A RP    L  P+      
Sbjct: 211  TGGGLEPQANGETPQVAVIVRPDDRSQGAII----------ADRP---GLPGPEHSPSES 257

Query: 1162 QTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVK------------- 1208
            Q ++   + SPSP   P    +   L I  +  T I+  ++ +T +              
Sbjct: 258  QPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEP 317

Query: 1209 ------MVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCL 1262
                  ++ +++  S+  PE E   S    A  P   H +E  +   +  SE       L
Sbjct: 318  TPLAEPILEVEVTLSKPVPESEFSSS-PLQAPTPLASHTVEIHEPNGMVPSED------L 370

Query: 1263 YTRQGAEPE-APHRAQPAE-PQPLGTQVPPEK--DRCTSPPGLSYMKAKEKTVEDLKSEE 1318
                 + PE AP  A P+E P P+     PE+  +   SPP +      E        EE
Sbjct: 371  EPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE-------PEE 423

Query: 1319 LAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRK----LLPKIPSP 1374
             A+E+       A +  P++   T         P  E  +EE ++  +       +  S 
Sbjct: 424  QAKEVT------ASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 477

Query: 1375 RSTEERKEEPSVPAAVSLATN-----STYYSTSAPKAELLIKMKDLQE 1417
            +  EE     S P   +L+ N     +T  + S PK    IK  + +E
Sbjct: 478  KGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 525



 Score = 31.2 bits (69), Expect = 8.5
 Identities = 15/40 (37%), Positives = 24/40 (60%), Gaps = 2/40 (5%)

Query: 363 PELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKD 402
           PE+ ++P   ++PG   +GSG P  P+E  AD +W   +D
Sbjct: 542 PEVENQPPAGSNPGPESEGSGVPPRPEE--ADETWDSKED 579


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 143/724 (19%), Positives = 237/724 (32%), Gaps = 122/724 (16%)

Query: 747  RIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSK 806
            R   + R     +  S++ P + +    +R YSP + P                     +
Sbjct: 279  RSRSKSRSRTRSRSPSHTRPRRRHR-SRSRSYSPRRRPSPRR-----------------R 320

Query: 807  PVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAG--TS 864
            P P+R    + +   PR +  R     R    +   S ++S   S  + S  +K    TS
Sbjct: 321  PSPRRRTPPRRMPPPPRHRRSRSPVRRRR-RSSASLSGSSSSSSSSRSRSPPKKPPKRTS 379

Query: 865  DLPRRLGTFAEYQASWKEQRKPLEA-------------RSSGRCHSADDILDVSLDPQER 911
              PR+    +   +  + + +P                + S R   +   +       + 
Sbjct: 380  SPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKV 439

Query: 912  PQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCR 971
             +H     R SPS     +   VEL     D G       S  +  + +   +Q+ +   
Sbjct: 440  TKHKGTEKRESPSPA--PKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSG 497

Query: 972  EGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLG 1031
              S    + P      N        H       P   + +  T PR  R    S P    
Sbjct: 498  SSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRR 557

Query: 1032 PRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREP---RRYRATDGAPADAPVG 1088
             R+ SP  P   R   + P      S  P  + P P +  P   RRY     +P+  P  
Sbjct: 558  RRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRY-----SPSPPPKR 612

Query: 1089 VLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDA-SRPL 1147
                P P P   +      +  +SHSP     + P    K       S+H  G + SR  
Sbjct: 613  RTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSP--VTKRRSPSLSSKHRKGSSPSRST 670

Query: 1148 PEALLP-PKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTT 1206
             EA  P P ++H          S SP P+ APQ  +  PP+      S +  +    +T 
Sbjct: 671  REARSPQPNKRH----------SPSPRPR-APQTSSSPPPVRRGASSSPQRRQSPSPSTR 719

Query: 1207 VKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQ 1266
                PI+ V    +P+K  + +   P              ++ +S+S             
Sbjct: 720  ----PIRRVSRTPEPKKIKKAASPSP------------QSVRRVSSSRSV---------- 753

Query: 1267 GAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGK 1326
               PE   +  PA P P+ +Q P         P +   KAK  T          +E  GK
Sbjct: 754  SGSPEPAAKKPPAPPSPVQSQSP----STNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGK 809

Query: 1327 DKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSV 1386
             K                        K +    +  ++ K   K    ++          
Sbjct: 810  KKK-----------------------KKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVT 846

Query: 1387 PAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISR 1446
            PAA++ AT      T+  + E +   +  +E +   ED+  DL+  L   +++ + S+ R
Sbjct: 847  PAAIAAAT------TTLAQEEPVAAPEPKKETESEAEDNLDDLEKHL---REKALRSM-R 896

Query: 1447 KLQV 1450
            K QV
Sbjct: 897  KAQV 900



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 43/352 (12%)

Query: 280 PRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPV 339
           PR    +  + + P +  + P    P  K+  +SPPPPP    S S    +    +  P 
Sbjct: 586 PRRRSPSPRRYSPPIQRRYSPS---PPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPK 642

Query: 340 FSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPP 399
              +   +  +    ++ R    P  + R  RS  P      S  P  PQ      S PP
Sbjct: 643 QRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQ---TSSSPPP 699

Query: 400 SKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQ 459
            + GASS  Q           QSP     P      +P       +        + SP  
Sbjct: 700 VRRGASSSPQRR---------QSPSPSTRPIRRVSRTP-------EPKKIKKAASPSPQS 743

Query: 460 VRGLSSCDQKLGSGWQGPR--PCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPR 517
           VR +SS     GS     +  P     +Q+        P+     A    P P+    PR
Sbjct: 744 VRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPS---PPR 800

Query: 518 HHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKA-SQRLAASIT-WADGE 575
           +   +  G    ++  + +  DK          +  +  + EKA +   AA++T  A   
Sbjct: 801 NSDQEGGGKKKKKKKDKKHKKDK--------KHKKHKKHKKEKAVAAAAAAAVTPAAIAA 852

Query: 576 SSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFA 627
           ++    QE P+      E K+  ES  ED+       + H+ +   RS R A
Sbjct: 853 ATTTLAQEEPV---AAPEPKKETESEAEDNL---DDLEKHLREKALRSMRKA 898



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 67/288 (23%), Positives = 104/288 (36%), Gaps = 49/288 (17%)

Query: 918  RSRSSPSTDHYKQEASVE-LRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPG 976
            R +    +   K+E S    RR++  P   R   P     +   S   +   + R  SP 
Sbjct: 154  RDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPA 213

Query: 977  SQQHPPSQKAPNP------PTFSELSHCRGAPELP-----------------REGRGRAG 1013
             ++   + + P P      P+  E +      ++P                 ++ + +  
Sbjct: 214  PEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEK 273

Query: 1014 TLPRD-YRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKR-- 1070
            T PR   R    S      P    P     +R +   P       +RP+P+R  PP+R  
Sbjct: 274  TRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMP 333

Query: 1071 EPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKAT 1130
             P R+R      + +PV    R     S ASL       S S S S  S + P+  PK T
Sbjct: 334  PPPRHRR-----SRSPVRRRRR-----SSASLSG-----SSSSSSSSRSRSPPKKPPKRT 378

Query: 1131 VC-ERGSQHVSGDAS------RPLPEALLPPKQQHLRLQTATMETSRS 1171
                R ++ +S  AS      RP P A  PPK +H      +  T +S
Sbjct: 379  SSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKS 426



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 80/391 (20%), Positives = 117/391 (29%), Gaps = 48/391 (12%)

Query: 246 RQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVP 305
           R+    A  +G    S    S  PP+ P      P  +       A+P           P
Sbjct: 347 RRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP-----------P 395

Query: 306 DKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPEL 365
            ++  PS P  PPP  R        +  +      S    +   T     + R    P  
Sbjct: 396 RRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKR--ESPSP 453

Query: 366 TDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHS 425
             +P +     S     G             +      +SS   +S SS D R  +S   
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVK 513

Query: 426 GRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDL 485
                    HSP    S    P     Q ++ P+ R   S         + P P      
Sbjct: 514 NGEVGRRRRHSP----SRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRR 569

Query: 486 QAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPE-----GPPDARETGRCYPLDK 540
           +         P+        S PP     SPR + P  +      PP  R T    P  K
Sbjct: 570 RRT-------PTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPK 622

Query: 541 GAEGCSAGAQEPP--RASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRP 598
                 A    PP  R S +    QR           SS +  + +P L S  ++G    
Sbjct: 623 R----RASPSPPPKRRVSHSPPPKQR-----------SSPVTKRRSPSLSSKHRKGSSPS 667

Query: 599 ESSPEDSATRPPPFDAHVGKPTRRSDRFATT 629
            S+ E  A  P P   H   P  R+ + +++
Sbjct: 668 RSTRE--ARSPQPNKRHSPSPRPRAPQTSSS 696


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 230/1044 (22%), Positives = 328/1044 (31%), Gaps = 152/1044 (14%)

Query: 116  SWHATKFSDSHPELAASPFTSTS-GCP----------SWSGRHHASSSSHDLSSSW-EQT 163
            SW    FS  H EL+ SP    S G P          +      +S    DL+  +  Q 
Sbjct: 1304 SWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQL 1363

Query: 164  NLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHT 223
                +LD      S  S  H SS L    S  +++  G  S +  +         TP   
Sbjct: 1364 ETDPSLDMKEQ--STRSSGHSSSEL----SPDAVEKAGMSSNQSISSPVLDAVPRTP--- 1414

Query: 224  LSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPE 283
             S+  +SSA +     GL   P +  R   + G   GS       P R    S  G  P 
Sbjct: 1415 -SRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGT-----PSR---HSLSGSSPG 1465

Query: 284  YNAEPKLAAPGRSNFGPVWYVPDKKKAPSSP-----PPPPPPLRSDSFAATKSHEKAQGP 338
                P+  + GRS        P+ K  P +P      P  P L +      +    ++  
Sbjct: 1466 MKDIPRTPSRGRSECDS---SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESS 1522

Query: 339  VFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWP 398
            V  +  A    T L Q    G  + EL  +P  S               PQE     S P
Sbjct: 1523 VDQKTVAR---TPLGQRSRSGSSQ-ELDVKPSAS---------------PQERSESDSSP 1563

Query: 399  PSKDGASSRL-QASLSSS----DVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQ 453
             SK    + L Q S S S    D +   SP   R     S  SP   D     P A S  
Sbjct: 1564 DSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-----SGSSPEVKDKPRAAPRAQSGS 1618

Query: 454  NDSP----PQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTA-LGALESLP 508
            + SP    P  R L     + GS  +G  P  +G             S TA  G+  S  
Sbjct: 1619 DSSPEPKAPAPRALPR-RSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE 1677

Query: 509  PPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAAS 568
            P T  ++P         P   R+          +      ++ PPR  R+   S    A 
Sbjct: 1678 PKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAE 1737

Query: 569  ITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFAT 628
                   S R     +P   + ++ G R P   P               + TRR DR  +
Sbjct: 1738 ---KSRSSRRRRSASSPRTKTTSRRG-RSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGS 1793

Query: 629  TLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQ 688
            +     Q    + Q+SRS   +T          R R G  G     P           A+
Sbjct: 1794 S-----QSTSRRRQRSRSRSRVT----------RRRRGGSGYHSRSP-----------AR 1827

Query: 689  ARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRI 748
                R +S +RR     P    P S +         P       A P +        P I
Sbjct: 1828 QESSRTSSRRRRGRSRTP----PTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLI 1883

Query: 749  GGRR---RFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETS 805
              RR   R +   + +S S          +R  SP    R+   T      R      + 
Sbjct: 1884 SRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRA-SPVSRRRSRSRTPPVTRRR----SRSR 1938

Query: 806  KPVPQRPAQKQALHGIPRDKPER--PRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGT 863
             P  +R ++ +      R    R  P T  R+   T P +R  S   +        ++ T
Sbjct: 1939 TPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRT 1998

Query: 864  SDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRS-S 922
            S + RR         + +  R         R  S   +L         P  +  RSRS +
Sbjct: 1999 SPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRT 2058

Query: 923  PSTDHYKQE-----ASVELRRQAGDPGE-PREELPSAVRAEEGQSTPRQADAQCREG--S 974
            P T   K+       ++  R  +G   +  R   P A R   G  TP  A    R    S
Sbjct: 2059 PRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFS 2118

Query: 975  PGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRA--GTLPRDYRYSEESTPADLGP 1032
              S    P  +  +P     L   R    + ++  G    G  PR   +   S P +   
Sbjct: 2119 RPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPEN--- 2175

Query: 1033 RAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPA--------D 1084
                     HA+ +    ++ AL +      RPPP              PA         
Sbjct: 2176 ---------HAQSR----IALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRT 2222

Query: 1085 APVGVLGRPFPTPSPASLDVYVAR 1108
            AP   L    P  S A++++  AR
Sbjct: 2223 APAANLASRIPAASAAAMNLASAR 2246



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 222/1112 (19%), Positives = 363/1112 (32%), Gaps = 180/1112 (16%)

Query: 123  SDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLD 182
            S+S PE+  S  +S            + S S   S +  + +L+R+L   S      S  
Sbjct: 743  SNSSPEMKKSRISS----------RRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQT 792

Query: 183  HPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLW 242
             P    S +    +         R S+       S TP     ++ +SS+ +     G  
Sbjct: 793  PPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSR---QSHSSSSPHPKVKSGT- 848

Query: 243  EAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAE-PKLAAPGRSNFGPV 301
              PRQG   +  A +   + ++ SCF           P PE  +  P   +   S+   V
Sbjct: 849  -PPRQGSITSPQANEQSVTPQRRSCFE--------SSPDPELKSRTPSRHSCSGSSPPRV 899

Query: 302  WYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDR 361
                  +++PS    P P +++      +SH  +  P  S   +        +  PR  R
Sbjct: 900  KSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS--------RTTPRRSR 951

Query: 362  RPELTDRPWRSAHPGSLGKGSGGPGC-------PQEAHADGSWPPSKDGASSRLQASLSS 414
                         P     GS  P         P+++H+    P  K  A +    SLS 
Sbjct: 952  SVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSG 1011

Query: 415  SDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGW 474
            S    PQ                LCA      P   S+   S  Q++G S       S  
Sbjct: 1012 SKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDT 1071

Query: 475  QGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGR 534
              P    Q   ++  L +    S    G       P    + R  + Q  G   A     
Sbjct: 1072 SSPE-VRQSHSESPSLQSKSQTSPK--GGRSRSSSPVTELASRSPIRQDRGEFSAS---- 1124

Query: 535  CYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEG 594
              P+ K            P  SR +  S       ++   +S+ +  Q        T E 
Sbjct: 1125 --PMLKSGMS--------PEQSRFQSDSS------SYPTVDSNSLLGQS----RLETAES 1164

Query: 595  KRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAG 654
            K +    P++ AT  PP       P    DR  ++L  +  +     ++S        AG
Sbjct: 1165 KEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERS-------GAG 1217

Query: 655  EAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESL 714
             + + T    + L   +Q+  L     +  +E   ++L   S + +++  +  +  PE +
Sbjct: 1218 SSPE-TKEQNSALPTSSQDEELMEVV-EKSEEPAGQILSHLSSELKEMSTSNFESSPE-V 1274

Query: 715  EHRMG-----DPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKM 769
            E R       D        EA      +S+ GGPH         F+ E K  S S P + 
Sbjct: 1275 EERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPH---------FSPEHKELSNS-PLRE 1324

Query: 770  NEVG--------------LTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQK 815
            N  G              +  G+S        ED  G F ++    E       +  + +
Sbjct: 1325 NSFGSPLEFRNSGPLGTEMNTGFS----SEVKEDLNGPFLNQ---LETDPSLDMKEQSTR 1377

Query: 816  QALHGIPRDKPERPRTAGRTCEGT------EPWSRTTSLGDSLNAHSAAEKAGTSDLPRR 869
             + H      P+    AG +   +      +   RT S   S +A S   K G    P R
Sbjct: 1378 SSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSR 1437

Query: 870  LGTFAEYQASWKEQRKPLEARSSGRCHSADDI----------LDVSLDPQERPQHVHGRS 919
                            P     SG      DI           D S +P+  PQ    RS
Sbjct: 1438 RSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRS 1497

Query: 920  RSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQ 979
            R SPS+     +     R ++G   E   +  +  R   GQ + R   +Q  +  P +  
Sbjct: 1498 R-SPSSPELNNKCLTPQRERSG--SESSVDQKTVARTPLGQRS-RSGSSQELDVKPSASP 1553

Query: 980  HPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGS 1039
               S+   +P +       +     P   R R+G+ P      E  + + L PR    GS
Sbjct: 1554 QERSESDSSPDS-------KAKTRTPLRQRSRSGSSP------EVDSKSRLSPRRSRSGS 1600

Query: 1040 PLHARGQD-SWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPS 1098
                + +  + P + +     P P + P P+  PRR R+   +    P            
Sbjct: 1601 SPEVKDKPRAAPRAQSGSDSSPEP-KAPAPRALPRRSRSGSSSKGRGP------------ 1647

Query: 1099 PASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQH 1158
                         S   S  + + P+  PK+    RGS+     +  P  ++  PP+++ 
Sbjct: 1648 -------------SPEGSSSTESSPEHPPKSRTARRGSR----SSPEPKTKSRTPPRRRS 1690

Query: 1159 LR----LQTATMETSRSPSPQFAPQKLTDKPP 1186
             R    L      + RS S   +P+  +  PP
Sbjct: 1691 SRSSPELTRKARLSRRSRSASSSPETRSRTPP 1722



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 202/949 (21%), Positives = 312/949 (32%), Gaps = 148/949 (15%)

Query: 296  SNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAAT------KSHEKAQGPVFSEAAAAQHF 349
            S+F P     + K+    PP P   +R  S + +      K  +K      SE+++ +  
Sbjct: 149  SSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRE 208

Query: 350  TALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQ 409
               +  + +     E   R  RS  P S  K        + + +    P S+    S   
Sbjct: 209  RKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKR--KRSRSTTPAPKSRRAHRSTSA 266

Query: 410  ASLSSSDVRFPQSPHSGR--HPPLYSDHSPLCA-------DSLGQEPGAASFQNDSPPQV 460
             S SSSD    +S  +    H    +  SP  A       D+   EPG  S Q  S P+ 
Sbjct: 267  DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPET 326

Query: 461  RGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGC-WPSDTALGALESLPPPTVGQSPRHH 519
                       +  Q   P    D    +  A    PS          P PT   + RH 
Sbjct: 327  -----------ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHG 375

Query: 520  -LPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSR 578
              PQP       +     P++  +E      + PP      K+ ++L  S   +  ESS 
Sbjct: 376  GSPQPLATTPLSQE----PVNPPSEASPTRDRSPP------KSPEKLPQS---SSSESSP 422

Query: 579  ICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHV--GKPTRRSDRFATTLRNEIQM 636
              PQ T +         R   SSPE     P P         PT ++       R++   
Sbjct: 423  PSPQPTKV--------SRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHS 474

Query: 637  HRAKLQKSRSTVALTAA------------GEAEDGTGRWR----AGLGGGTQEGPLAGTY 680
            H    +  RS    TA             G +   + +WR    A   G ++     G  
Sbjct: 475  HTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRS 534

Query: 681  KDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPS--- 737
            +   +   +R  R T  + R      G  +  S   R       P       ++ P+   
Sbjct: 535  RSPQRPGWSRS-RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRR 593

Query: 738  STSGGPH--------PPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSED 789
            S S  P         P R G  R  T  ++      P +      +R  SP +  R+   
Sbjct: 594  SRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRR----SRSRSPAR--RSGRS 647

Query: 790  TVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLG 849
               T A R +    T    P R  + ++     R    R RT  R        SRT   G
Sbjct: 648  RSRTPARRGRSRSRT----PARRGRSRSRTPARRSGRSRSRTPARRGRSR---SRTPRRG 700

Query: 850  DSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQ 909
             S +          S  P+R G     ++    +RK     S  R  S       +  P+
Sbjct: 701  RSRSRSLVRRGRSHSRTPQRRG-----RSGSSSERKNKSRTSQRRSRS-------NSSPE 748

Query: 910  ERPQHVHGRSRSSPSTDHYKQEASVELRRQ--AGDPGEPREELPSAVRAEEGQSTPRQAD 967
             +   +  R   S S+   K ++ + LRR      P   ++      R+  G S P+   
Sbjct: 749  MKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKS 808

Query: 968  AQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRG---RAGTLPRDYRYSEE 1024
                  S  S   PP QK+  P   S  SH   +P  P+   G   R G++       + 
Sbjct: 809  RTPPRRSRSSSSPPPKQKSKTP---SRQSHSSSSPH-PKVKSGTPPRQGSITSPQANEQS 864

Query: 1025 STP-------ADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPR---- 1073
             TP       +   P  +S     H+    S P   +    R +P R   P+ + +    
Sbjct: 865  VTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIIS 924

Query: 1074 -RYRATDGAPADAPVGVLGRPFP----TPSPAS--LDVYVARLSLSHSPSVFSSAQPQDT 1126
             R R+  G+ + +P  V  R  P    + SP S      + R S S S S  +  +P+  
Sbjct: 925  PRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETP 984

Query: 1127 PKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQ 1175
            P+         H    +  P  +A  PP          ++  S+SP PQ
Sbjct: 985  PR-------QSHSGSISPYPKVKAQTPP--------GPSLSGSKSPCPQ 1018



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 226/1092 (20%), Positives = 343/1092 (31%), Gaps = 181/1092 (16%)

Query: 177  SVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTS-----SSTPDHTLSKADTSS 231
            S+ S    S +   ++S+S +  L S S      G FS S       +P+ +  ++D+SS
Sbjct: 1085 SLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSS 1144

Query: 232  AENILYTVGLWEAPRQGGR---------QAQAAGDPQGSEEKLSCFPP------------ 270
               +     L ++  +            Q  A   P   ++K S FP             
Sbjct: 1145 YPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKD 1204

Query: 271  --RVPGD--SGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAP--------------- 311
              R P    SG G  PE   E   A P  S    +  V +K + P               
Sbjct: 1205 TLRTPPRERSGAGSSPE-TKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEM 1263

Query: 312  ------SSPPPPPPP---LRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRR 362
                  SSP     P   L  D   +  S E  + P  + +    HF+   +       R
Sbjct: 1264 STSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLR 1323

Query: 363  PELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWP--------PSKDGASSRLQASLSS 414
                  P    + G LG      G   E   D + P        PS D      ++S  S
Sbjct: 1324 ENSFGSPLEFRNSGPLGTEMN-TGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHS 1382

Query: 415  SDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVR-GLSSCDQKLGSG 473
            S    P +          S  SP+  D++ + P      + S P+++ GL     +    
Sbjct: 1383 SSELSPDAVEKAGMSSNQSISSPVL-DAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRS 1441

Query: 474  WQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLP-PPTVGQSPRHHLPQPEGPPDA-RE 531
               P         +    +G  P       ++ +P  P+ G+S     P+P+  P   R 
Sbjct: 1442 GSSPGLRDGSGTPSRHSLSGSSPG------MKDIPRTPSRGRSECDSSPEPKALPQTPRP 1495

Query: 532  TGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLT 591
              R     +    C    +E  R+       Q+  A      G+ SR            +
Sbjct: 1496 RSRSPSSPELNNKCLTPQRE--RSGSESSVDQKTVARTPL--GQRSR---------SGSS 1542

Query: 592  QEGKRRPESSPED--SATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVA 649
            QE   +P +SP++   +   P   A    P R+  R  ++   +         KSR +  
Sbjct: 1543 QELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVD--------SKSRLSPR 1594

Query: 650  LTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPG-D 708
             + +G + +   + RA         P A +  D   E +A   RA   + R    + G  
Sbjct: 1595 RSRSGSSPEVKDKPRAA--------PRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRG 1646

Query: 709  LYPESLEHRMGDPDTVPHFWEA--GLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEP 766
              PE        P+  P    A  G    P   +    PPR           +  S S P
Sbjct: 1647 PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPR-----------RRSSRSSP 1695

Query: 767  EKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKP 826
            E   +  L+R     +   +S +T      R +     S P P   ++        R   
Sbjct: 1696 ELTRKARLSRR---SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRR----RRSA 1748

Query: 827  ERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLG----TFAEYQASWKE 882
              PRT   +  G  P  +   L  S  + S  EK  T+    R G    T    Q S   
Sbjct: 1749 SSPRTKTTSRRGRSPSPKPRGLQRS-RSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSR 1807

Query: 883  QRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQE----ASVELRR 938
             R     R     HS       S     R +   GRSR+ P++    +     A  +  R
Sbjct: 1808 SRVTRRRRGGSGYHSRSPARQESSRTSSRRRR--GRSRTPPTSRKRSRSRTSPAPWKRSR 1865

Query: 939  QAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHC 998
                P   R            +S  R +    R     +       ++   P     S  
Sbjct: 1866 SRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRS 1925

Query: 999  RGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSK 1058
            R  P   R  R R    P   R S   TP     R++S   P+  R   S    ++ +++
Sbjct: 1926 RTPPVTRRRSRSRT---PTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRS---RTSPITR 1979

Query: 1059 RPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVF 1118
            R +  R  P  R   R R +       PV    R     SP +      R S S +P   
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTS-------PV-TRRRSRSRTSPVT-----RRRSRSRTPPAI 2026

Query: 1119 SSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAP 1178
                   TP                       LLP K+   R   A    SRS +P+ A 
Sbjct: 2027 RRRSRSRTP-----------------------LLPRKRSRSRSPLAIRRRSRSRTPRTAR 2063

Query: 1179 QK--LTDKPPLL 1188
             K  LT  PP +
Sbjct: 2064 GKRSLTRSPPAI 2075



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 114/540 (21%), Positives = 191/540 (35%), Gaps = 76/540 (14%)

Query: 693  RATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRR 752
            R+ S   ++LD  P    P+        PD+     +A    P    S     P +  + 
Sbjct: 1536 RSRSGSSQELDVKPS-ASPQERSESDSSPDS-----KAKTRTPLRQRSRSGSSPEVDSKS 1589

Query: 753  RFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRP 812
            R +  +  +S S PE  ++        P   PR    +              S P P+ P
Sbjct: 1590 RLSPRRS-RSGSSPEVKDK--------PRAAPRAQSGS-------------DSSPEPKAP 1627

Query: 813  AQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGT 872
            A        PR  P R R+ G + +G  P    +S  +S   H    +        R G+
Sbjct: 1628 A--------PRALPRRSRS-GSSSKGRGPSPEGSSSTESSPEHPPKSRTA------RRGS 1672

Query: 873  FAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEA 932
             +  +   K  R P   RSS    S+ ++         R   +  RSRS+ S+   +   
Sbjct: 1673 RSSPEPKTKS-RTPPRRRSS---RSSPELT--------RKARLSRRSRSASSSPETRSRT 1720

Query: 933  SVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNP-PT 991
                RR           + S   AE+ +S+ R+  A     SP ++      ++P+P P 
Sbjct: 1721 PPRHRRSPS--------VSSPEPAEKSRSSRRRRSAS----SPRTKTTSRRGRSPSPKPR 1768

Query: 992  FSELSHCRGAPELPR--EGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSW 1049
              + S  R   E  R    R R+G+     R  + S       R +  GS  H+R     
Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQ 1828

Query: 1050 PVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARL 1109
              S     +R    R PP  R+  R R T  AP               S +   +   R 
Sbjct: 1829 ESSRTSSRRRRGRSRTPPTSRKRSRSR-TSPAPWKRSRSRASPATHRRSRSRTPLISRRR 1887

Query: 1110 SLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPP-KQQHLRLQT-ATME 1167
            S S +  V   ++ +   + +V  R S+  +   SR    +  PP  ++  R +T  T  
Sbjct: 1888 SRSRTSPV---SRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944

Query: 1168 TSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQ 1227
             SRS +P    ++   + P + +    +R   +    +  +  P+    S S+    +R+
Sbjct: 1945 RSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRR 2004



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 85/394 (21%), Positives = 125/394 (31%), Gaps = 40/394 (10%)

Query: 945  EPREELPSAVRAEEGQSTPRQADAQCREGS---PGSQQHPPSQKAPNPPTFSELSHCRGA 1001
            +PR     AV    G  TP    A    GS   P +  +P S + P  P  + L   R A
Sbjct: 2286 DPRTPTAPAVNLA-GARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSA 2344

Query: 1002 ---PELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSK 1058
                 +   G   A  L      S    PA  G    SP  PL A  + S   S  LL +
Sbjct: 2345 HATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDR 2404

Query: 1059 ---RPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPF------PTPSPASLD---VYV 1106
               R  P  P   +    R  +       AP   L  P       P PS  S     +  
Sbjct: 2405 ARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA 2464

Query: 1107 ARLSLSHSPSVFSSAQPQDTPKA-------TVCERGSQH-------VSGDASRPLPEALL 1152
                ++ S S+ S A    T  A       +V   G  H        S  A +P   A L
Sbjct: 2465 QTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL 2524

Query: 1153 PPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDST-------RIERVMDNNT 1205
             P ++     +++  +S S S   +    +         E S+        ++RV     
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTP 2584

Query: 1206 TVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTR 1265
              K    +    E  P K  R+S +  +   +           + S+S    S     + 
Sbjct: 2585 APKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2644

Query: 1266 QGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPP 1299
              + P        A P+P   + PP  +R +  P
Sbjct: 2645 SSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP 2678


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 2/86 (2%)

Query: 24  GRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLS 83
           G  + + ++GGAPWGF L+GG+E  +PL + KI   SKA+    L  GDE+V IN    +
Sbjct: 4   GDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASG-SGLCEGDEVVSINGNPCA 62

Query: 84  GFR-QEAICLVKGSHKTLKLVVKRRS 108
                E I L++    +L++++KR S
Sbjct: 63  DLTYPEVIKLMESITDSLQMLIKRPS 88


>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 2/86 (2%)

Query: 24  GRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLS 83
           G  + + ++GGAPWGF L+GG+E  +PL + KI   SKA+    L  GDE+V IN    +
Sbjct: 4   GDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASG-SGLCEGDEVVSINGNPCA 62

Query: 84  GFR-QEAICLVKGSHKTLKLVVKRRS 108
                E I L++    +L++++KR S
Sbjct: 63  DLTYPEVIKLMESITDSLQMLIKRPS 88


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 2/86 (2%)

Query: 24  GRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLS 83
           G  + + ++GGAPWGF L+GG+E  +PL + KI   SKA+    L  GDE+V IN    +
Sbjct: 4   GDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASG-SGLCEGDEVVSINGNPCA 62

Query: 84  GFR-QEAICLVKGSHKTLKLVVKRRS 108
                E I L++    +L++++KR S
Sbjct: 63  DLTYPEVIKLMESITDSLQMLIKRPS 88


>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
          Length = 329

 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 31/194 (15%)

Query: 28  EVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ 87
           ++ L G  PWGF L GG++  +PL I+++  GSKAA  + L  GD I  I+    S    
Sbjct: 5   QIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALAN-LCIGDVITAIDGENTSNMTH 63

Query: 88  -EAICLVKGSHKTLKLVVKRRSELGWRP--------HSWHATKFSDSHPEL--------A 130
            EA   +KG    L L V R     W P        H +     S+    L        +
Sbjct: 64  LEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRS 123

Query: 131 ASPFTSTSGCPSWSGRHHASSSSHD----LSSSWEQTNLQRTLDHFSSLGSVDS----LD 182
           A PFT++   P+ S      ++ ++    L SS   +N    L+  ++   V++    LD
Sbjct: 124 AMPFTAS---PASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD 180

Query: 183 H--PSSRLSVAKSN 194
           H  P S L + K +
Sbjct: 181 HAQPPSSLVIDKES 194


>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
          Length = 316

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 36/87 (41%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGF-RQ 87
           V L G APWGF L GG +  +PLVIT+I  GSKAAA + L  GD I+ I+  G       
Sbjct: 5   VILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAAN-LCPGDVILAIDGFGTESMTHA 63

Query: 88  EAICLVKGSHKTLKLVVKRRSELGWRP 114
           +A   +K +   L L + R     W P
Sbjct: 64  DAQDRIKAAAHQLCLKIDRGETHLWSP 90


>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
          Length = 364

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 36/87 (41%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGF-RQ 87
           V L G APWGF L GG +  +PLVIT+I  GSKAAA + L  GD I+ I+  G       
Sbjct: 5   VILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAAN-LCPGDVILAIDGFGTESMTHA 63

Query: 88  EAICLVKGSHKTLKLVVKRRSELGWRP 114
           +A   +K +   L L + R     W P
Sbjct: 64  DAQDRIKAAAHQLCLKIDRGETHLWSP 90


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 33/86 (38%), Positives = 47/86 (54%), Gaps = 2/86 (2%)

Query: 27  VEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGF- 85
           V V LSGGAPWGF L GG E  +PL ++KI   S+A     L   D+++ IN +  +   
Sbjct: 7   VLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAG-LRERDQLLAINGVSCTNLS 65

Query: 86  RQEAICLVKGSHKTLKLVVKRRSELG 111
              A+ L+  S   L L V+R ++ G
Sbjct: 66  HASAMSLIDASGNQLVLTVQRLADEG 91



 Score = 35.0 bits (79), Expect = 0.59
 Identities = 38/140 (27%), Positives = 49/140 (35%), Gaps = 13/140 (9%)

Query: 937  RRQAGDPGEPREELPSAVRAEEGQSTPRQADAQ--CREGSPGSQQHPPSQKAPNPPTFSE 994
            R +A  PG    E PSA          R    Q   R G+      P  ++  N P    
Sbjct: 593  RPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPEL 652

Query: 995  LSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSA 1054
            LS  +   E PR G   +G          E     LG  A +   P+ AR   + P  + 
Sbjct: 653  LSLVQNLDEKPRAGGAESG---------PEEDALSLGAEACNFMQPVGARSYKTLPHVTP 703

Query: 1055 LLSKRPAPQRPPP--PKREP 1072
                  AP+ PPP  PK  P
Sbjct: 704  KTPPPMAPKTPPPMTPKTPP 723



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 53/235 (22%), Positives = 80/235 (34%), Gaps = 16/235 (6%)

Query: 955  RAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRG---- 1010
            RA EGQ +      Q  E S    Q    Q+     +  EL+    A  L  EG      
Sbjct: 367  RASEGQGSG--LGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPR 424

Query: 1011 ------RAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQR 1064
                   A  LP     +  ++P    P   +P        + + P +  L  +RP    
Sbjct: 425  AQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTS 484

Query: 1065 PPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQ 1124
                   P+R   + G  + AP   L    PTP P+      +   +S SPS   S+ P 
Sbjct: 485  VIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPV 544

Query: 1125 DTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQ 1179
                +      S+ V+   +   PE   PP    +   TA++  S    P   P+
Sbjct: 545  TATSSLYIPAPSRPVTPGGA---PEPPAPPSAAAM-TSTASIFLSAPLRPSARPE 595


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 75/299 (25%), Positives = 103/299 (34%), Gaps = 45/299 (15%)

Query: 956  AEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTL 1015
            AE  +  P+        G   S    P       PT SE       P  P     R    
Sbjct: 1020 AEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISE-GPVPSLPIRPSRAPSRTPGP 1078

Query: 1016 PRDYRYSEESTPADLGPRA----QSPGSPLHARGQDSWPVSSALLSKRPAP-QRPPPPK- 1069
            P     S +S+P D  P      + P  PL  +     P        RPAP QRPPPP  
Sbjct: 1079 P-----SAQSSPIDAQPATPLPQKDPAQPLEPKRPP--PPRPVAPPTRPAPPQRPPPPSG 1131

Query: 1070 -REPRRYRATDGAPADAPV---GVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQD 1125
             R P   R   GAP          +GR  P+P                 P+ +S+A+P  
Sbjct: 1132 ARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLA---------GPGPAGYSTARPTI 1182

Query: 1126 TPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKP 1185
             P+A V      H    A R  PE+           Q+ T ETS+  +  F P+ L  + 
Sbjct: 1183 PPRAGVISAPQSHARASAGRLTPES-----------QSKTSETSKGST--FLPEPLKPQA 1229

Query: 1186 PLLIQDEDSTRIERVMDNNTTV-----KMVPIKIVHSESQPEKESRQSLACPAEPPALP 1239
                Q       +R+ +    V     +  P   + +  QP   SR S + P+E  + P
Sbjct: 1230 AFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQP 1288


>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
          Length = 214

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G APWGF L+GG++   PL I+ +++G KAA  + +  GD ++ I+ I   G    
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQAN-VRIGDVVLSIDGINAQGMTHL 64

Query: 88  EAICLVKGSHKTLKLVVKRRS 108
           EA   +KG   +L + ++R S
Sbjct: 65  EAQNKIKGCTGSLNMTLQRAS 85


>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
          Length = 234

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G APWGF L+GG++   PL I+ +++G KAA  + +  GD ++ I+ I   G    
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQAN-VRIGDVVLSIDGINAQGMTHL 64

Query: 88  EAICLVKGSHKTLKLVVKRRS 108
           EA   +KG   +L + ++R S
Sbjct: 65  EAQNKIKGCTGSLNMTLQRAS 85


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G APWGF L+GG++   PL I+ +++G KAA  + +  GD ++ I+ I   G    
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQAN-VRIGDVVLSIDGINAQGMTHL 64

Query: 88  EAICLVKGSHKTLKLVVKRRS 108
           EA   +KG   +L + ++R S
Sbjct: 65  EAQNKIKGCTGSLNMTLQRAS 85


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G APWGF L+GG++   PL I+ +++G KAA  + +  GD ++ I+ I   G    
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQAN-VRIGDVVLSIDGINAQGMTHL 64

Query: 88  EAICLVKGSHKTLKLVVKRRS 108
           EA   +KG   +L + ++R S
Sbjct: 65  EAQNKIKGCTGSLNMTLQRAS 85


>gi|145199237 transcription elongation factor B polypeptide 3 binding
            protein 1 [Homo sapiens]
          Length = 1221

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 109/479 (22%), Positives = 181/479 (37%), Gaps = 62/479 (12%)

Query: 907  DPQERPQHVHGRSRSSPSTDHYKQEASVELRRQA-------GDPGEPREELPSAVRAEEG 959
            D ++    V G   ++ ST   + +  ++   Q         + G  RE   +AV+ + G
Sbjct: 288  DSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVG 347

Query: 960  QSTPRQAD----AQCREGSPGS---QQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRA 1012
               P  A     AQ +    G    +  P  +K   PP  S     +G  +   +GRGR 
Sbjct: 348  DLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRP 407

Query: 1013 GTLPR-DYRYSEESTPADLGPRAQ------SPGSPL--HARGQDSWPVSSALLSKRPAP- 1062
               PR D +  + S+P     R +      S  +P+    +G+   P      ++RP+P 
Sbjct: 408  VEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRP------ARRPSPT 461

Query: 1063 ---QRPPPPKREPRRYRATDGAPADAPVGVL--GRPFPTPSPASLDV-YVARLSLSHSPS 1116
                RP   +  PR  +  D     AP G L   +       AS D   + + +LSH+  
Sbjct: 462  SGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADL 521

Query: 1117 VFSSAQ--------PQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMET 1168
                ++        P   P A            D+S   PEA  PPK    RL+ A+   
Sbjct: 522  FGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPK----RLK-ASPPP 576

Query: 1169 SRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQS 1228
            S +PS   +    T        D D + +E+ +D ++      ++I +  +  + E R  
Sbjct: 577  SPAPSSSSSSSSSTSSAG---ADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGR 633

Query: 1229 LACPAEPPALPHGLEK--DQIKTLSTSEQFYSRFCLYTRQGAEPEAPHR--AQPAEPQPL 1284
            LA   +PP      EK    + TL   ++   R    ++QG E E P R  A P    P 
Sbjct: 634  LA--RQPPKEEKSEEKGLSGLTTLFPGQK--RRISHLSKQGQEVEPPRRGPAVPPARPPT 689

Query: 1285 GTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTT 1343
              +V   + +       S ++A  +  E  KS  +     G+ + +A I +P +    T
Sbjct: 690  AQEVCYLRAQQAQRASASLLQAPARLAE--KSPSVHISAPGEKRRIAHIPNPRLAAAPT 746


>gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]
          Length = 246

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 35/85 (41%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G +PWGF L GGR+   PL I+++  GSK AA+  L  GD I  IN          
Sbjct: 5   VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSK-AALAALCPGDLIQAINGESTELMTHL 63

Query: 88  EAICLVKGSHKTLKLVVKRRSELGW 112
           EA   +KG H  L L V R     W
Sbjct: 64  EAQNRIKGCHDHLTLSVSRPEGRSW 88


>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
          Length = 330

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 35/85 (41%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
           V L G +PWGF L GGR+   PL I+++  GSK AA+  L  GD I  IN          
Sbjct: 5   VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSK-AALAALCPGDLIQAINGESTELMTHL 63

Query: 88  EAICLVKGSHKTLKLVVKRRSELGW 112
           EA   +KG H  L L V R     W
Sbjct: 64  EAQNRIKGCHDHLTLSVSRPEGRSW 88


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 48/162 (29%), Positives = 78/162 (48%), Gaps = 13/162 (8%)

Query: 4   AEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAA 63
           AEP A P +L EA        R V V+ +     G ++KGGRE+  P++I+KI +G  A 
Sbjct: 68  AEPGAGPPQLPEALLLQR---RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAAD 124

Query: 64  AVDKLLAGDEIVGINDIGL-SGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKF 122
             + L  GD I+ +N   L S    EA+ ++K + K + L VK   ++   P+  ++T  
Sbjct: 125 QTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVS--PYFKNSTGG 182

Query: 123 S----DSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSW 160
           +    DS P   ASP       P  + R+ + +    L  ++
Sbjct: 183 TSVGWDSPP---ASPLQRQPSSPGPTPRNFSEAKHMSLKMAY 221


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 49/197 (24%), Positives = 77/197 (39%), Gaps = 23/197 (11%)

Query: 912  PQHVHGRSRSSPSTDHYKQEASVELRRQAGDPG-----EPREELPSAVRAEEGQSTPRQA 966
            P  V  R  +SP     K++   E  ++          + R+ LP++ RA    ST  + 
Sbjct: 400  PAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASEL 459

Query: 967  D--AQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEE 1024
               ++ R  SP +  H P+   P+P     L      P  P   RG   +     R  EE
Sbjct: 460  SPKSKARPSSPSTSWHRPASPCPSPGPGHTL------PPKPPSPRGTTASPKGRVRRKEE 513

Query: 1025 S--TPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAP 1082
            +  +P+  GP  +S      +  ++S   +S   S  P+P   PP K +P     TD A 
Sbjct: 514  AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573

Query: 1083 ADAPVGVLGRPFPTPSP 1099
              +P        P P+P
Sbjct: 574  LTSP--------PAPAP 582



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 41/197 (20%), Positives = 74/197 (37%), Gaps = 22/197 (11%)

Query: 455 DSPPQVRGLSSCDQ-----KLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPP 509
           D+PP ++  +S  Q     +  SG  GPRP    +   +       P+  A+G  ++ PP
Sbjct: 50  DTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPP 109

Query: 510 PTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASI 569
               Q     +P  + PP  +E  +     K A           +  R E+A    A   
Sbjct: 110 RRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA-----------KERREERAKYLAAKKA 158

Query: 570 TWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHV-GKPTRRSDRFAT 628
            W + E      +E  L     QE +RR E     +  R    +     K  +  +R+  
Sbjct: 159 VWLEKEEKAKALREKQL-----QERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEA 213

Query: 629 TLRNEIQMHRAKLQKSR 645
            ++  ++   A++++ R
Sbjct: 214 AIQRSVKKTWAEIRQQR 230



 Score = 31.2 bits (69), Expect = 8.5
 Identities = 39/136 (28%), Positives = 47/136 (34%), Gaps = 22/136 (16%)

Query: 279 GPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPP--------PPPLRSDSFAATK 330
           GPR E  A    A   R+   P    P  +  PS PPPP        PP        AT 
Sbjct: 4   GPRAELGAGAPPAVVARTPPEPR---PSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATS 60

Query: 331 SH------EKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDR----PWRSAHPGSLG- 379
           S       E   G V    A  Q  +  ++A+ RG   P +  R    P RS+ P     
Sbjct: 61  SKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV 120

Query: 380 KGSGGPGCPQEAHADG 395
             S  P   QE    G
Sbjct: 121 PASDSPPTKQEVKKAG 136



 Score = 31.2 bits (69), Expect = 8.5
 Identities = 20/68 (29%), Positives = 28/68 (41%), Gaps = 1/68 (1%)

Query: 943  PGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKA-PNPPTFSELSHCRGA 1001
            P  P+EE PS+     G + P       R     SQ  P +  A  +PPT  E+      
Sbjct: 79   PAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGER 138

Query: 1002 PELPREGR 1009
             +L +E R
Sbjct: 139  HKLAKERR 146


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 121/517 (23%), Positives = 167/517 (32%), Gaps = 100/517 (19%)

Query: 859  EKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGR 918
            E A  +   R  GT +   AS    R P    +SGR   A    + S  P   P    G 
Sbjct: 72   ESAPRAGPTRSAGTSSRNPAS----RPP----ASGRGERAPPAKNTSPGPVSSPGRASGT 123

Query: 919  SRSSP-STDHYKQEASVELRRQAGDPGEPREELPSAVRAEE-----GQSTPRQADAQCRE 972
            +R  P      +  A   + R        R  L +  R +      G  +P  A      
Sbjct: 124  TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183

Query: 973  GSPGSQQHPPSQKAPNPPT---------FSELSHCRGAPEL---PREGRGRAGTLPRDYR 1020
            G+      P     P PPT          SE S    +P     P  G G      R   
Sbjct: 184  GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243

Query: 1021 YSEE--STPADLGPRAQ-SPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRA 1077
             S    S+PA  GP A+ +P +P H     S P    L + RP PQ  PP K        
Sbjct: 244  SSATPLSSPARSGPSARGTPRAPAHP----SQPKPKGLQALRP-PQVTPPRK-------- 290

Query: 1078 TDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQ 1137
             D APA  P+     P  TPSP+                  + A+P   P          
Sbjct: 291  -DAAPALGPLS--SSPLATPSPSG-----------------TKARPVPPPD--------- 321

Query: 1138 HVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRI 1197
                +A+ PLP  L P       L  A    S  PS Q  P      P    Q   S   
Sbjct: 322  ----NAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPS---QAPPSMTT 374

Query: 1198 ERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFY 1257
              +    +   + PI++ HS + P      SL  P  P AL   L+        T +  +
Sbjct: 375  PPMQAPPSLQTIPPIQVPHSLTSP------SLQAPPSPLAL-SSLQATTSLGSPTLQATH 427

Query: 1258 SRFCLYTRQG----AEPEAPHRAQPAEP-----------QPLGTQVPPEKDRCTSPPGLS 1302
            S   +  RQ       P  P    P  P            PL T + P     +SP  + 
Sbjct: 428  SFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIH 487

Query: 1303 YMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVK 1339
             ++A            L+  I+   ++ + +  PS++
Sbjct: 488  PLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQ 524



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 115/459 (25%), Positives = 155/459 (33%), Gaps = 76/459 (16%)

Query: 878  ASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELR 937
            AS      PL+A  S     A   L  SL P   P        SSP T H  Q  S    
Sbjct: 448  ASTPPDSPPLQAPLS---LPASPPLQTSLSPAVSPL-------SSPLTIHPLQALSSLAS 497

Query: 938  RQAGDPGE----PREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFS 993
                 P      P  E  S++     Q+ P        E  P S   PP Q A  P T  
Sbjct: 498  HSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLP-SLAPPPLQTASAPLTTP 556

Query: 994  ELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSS 1053
             L         P +      T P     S  +TP    P A +   PL  +G  S P+S 
Sbjct: 557  HLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALA-SPPL--QGLPSPPLSP 613

Query: 1054 ALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSH 1113
                  P PQ PP     P   +A    PA  P+  L  P P  +P +L V++ +   S 
Sbjct: 614  LAT---PPPQAPPXLALPP--LQAPPSPPASPPLSPLATPSPQ-APNALAVHLLQAPFSP 667

Query: 1114 SPSV-----FSS-AQPQDTPKATVCERGSQHV---------SGDASRPLPEALLPPKQQH 1158
             PS      FS  A P  +P AT   +    +         S  AS P+  +  PP Q  
Sbjct: 668  PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 727

Query: 1159 LRLQTATMETSRSP--SPQFAPQKLTDK--PPLLIQDEDSTRIERVMDNNTTVKMVPIKI 1214
              L    ++   SP  SP  +P        PPLL                      P+++
Sbjct: 728  PPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAP-------------------PLQV 768

Query: 1215 VHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPH 1274
                S P       LA P  PP  P  L    ++ L +    +     ++   + P +P 
Sbjct: 769  --PPSPPASLPMSPLAKP--PPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 824

Query: 1275 RAQPAEPQPLGT----QVPPEKDRCTSPPGLSYMKAKEK 1309
               P +  P+      QVPP      SPP    ++A  +
Sbjct: 825  ATPPPQAPPVLAAPLLQVPP------SPPASPTLQAPRR 857



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 95/383 (24%), Positives = 133/383 (34%), Gaps = 71/383 (18%)

Query: 250 RQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNA-------EPKLAAPGRSNFGPVW 302
           R+++AAG   G         PR P +   GPR   ++       EP  AA  R + G   
Sbjct: 178 RRSRAAGTEVGLPRPAPSARPRPPTE---GPRKSVSSASEHSTTEPSPAARRRPSAGGGL 234

Query: 303 YVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDR- 361
             P  +   SS  P   P RS   A       A                 +Q +P+G + 
Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP---------------SQPKPKGLQA 279

Query: 362 -RPELTDRPWRSAHPGSLGKGSGGP-GCPQEAHADGSWPPSKDGASSRLQASLSSSD--- 416
            RP     P + A P +LG  S  P   P  +       P  D A++ L A+L  S    
Sbjct: 280 LRPPQVTPPRKDAAP-ALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLA 338

Query: 417 VRFPQSPHSGRHPP-LYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQ 475
              P +P S   PP L +  SP         P   +    +PP ++ +           Q
Sbjct: 339 TPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPI--------Q 390

Query: 476 GPRPCVQGDLQAAQLWAGCWPSDTALGALE---SLPPPTVGQSPRHHLPQPEGPPDARET 532
            P       LQA        PS  AL +L+   SL  PT+ Q+    L        A  T
Sbjct: 391 VPHSLTSPSLQAP-------PSPLALSSLQATTSLGSPTL-QATHSFLTMSPRQTQASLT 442

Query: 533 GRCYPLDKGAEGCSAGAQEPP-RASRAEKASQRLAASITWADGESSRICPQETPL----L 587
               P        S     PP +A  +  AS  L  S+      S  + P  +PL    L
Sbjct: 443 SPSRP-------ASTPPDSPPLQAPLSLPASPPLQTSL------SPAVSPLSSPLTIHPL 489

Query: 588 HSLTQEGKRRPESSPEDSATRPP 610
            +L+      P+ +P  S   PP
Sbjct: 490 QALSSLASHSPQ-APLSSLIMPP 511



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 48/191 (25%), Positives = 65/191 (34%), Gaps = 24/191 (12%)

Query: 282  PEYNAEPKLAAPGRSNF-GPVWYVPDKKKAPS-SPPPPPPPLRSDSFAATKSHEKAQGPV 339
            P   A P L AP R    GP   V   +   + +P PPPPP RS S  +T S     G  
Sbjct: 844  PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS--STLSGPDLAGHS 901

Query: 340  FSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKG-------SGGPGCPQEAH 392
             S  +  +           G       D    + HP +  +G        G PG P    
Sbjct: 902  SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPL--- 958

Query: 393  ADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEP--GAA 450
                WPP+    S+    ++  +     + P S    P   D  P    S G+      A
Sbjct: 959  ---PWPPATGPGSADGLCTIYET-----EGPESATPAPGALDPGPSPGTSGGKAAAGAGA 1010

Query: 451  SFQNDSPPQVR 461
               + SP Q R
Sbjct: 1011 GASSRSPKQAR 1021



 Score = 35.0 bits (79), Expect = 0.59
 Identities = 57/205 (27%), Positives = 76/205 (37%), Gaps = 33/205 (16%)

Query: 248 GGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKG-PR-PEYNAEPKLAAPGRSNFGPVWYVP 305
           GG Q  A+     S   LS   P   G S +G PR P + ++PK    G     P    P
Sbjct: 232 GGLQRPASRSLSSSATPLSS--PARSGPSARGTPRAPAHPSQPK--PKGLQALRPPQVTP 287

Query: 306 DKKKA-PSSPPPPPPPLRSDSFAATKSH-----EKAQGPVFSEAAAAQHF-TALAQAQPR 358
            +K A P+  P    PL + S + TK+      + A  P+ +    +    T L  A P 
Sbjct: 288 PRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPS 347

Query: 359 GDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVR 418
               P L   P   A P            P +A    + PP        +QA  S   + 
Sbjct: 348 PSAPPSLQTLPSPPATP------------PSQAPPSMTTPP--------MQAPPSLQTIP 387

Query: 419 FPQSPHSGRHPPLYSDHSPLCADSL 443
             Q PHS   P L +  SPL   SL
Sbjct: 388 PIQVPHSLTSPSLQAPPSPLALSSL 412



 Score = 35.0 bits (79), Expect = 0.59
 Identities = 78/314 (24%), Positives = 104/314 (33%), Gaps = 77/314 (24%)

Query: 269  PPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAA 328
            PP+ P      P     + P  + PG++ F P   +P    A  +PPP  PP+ +     
Sbjct: 785  PPQAPPALATPPLQALPSPPA-SFPGQAPFSPSASLPMSPLA--TPPPQAPPVLA----- 836

Query: 329  TKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSG----- 383
                                   L Q  P     P L   P R   PG     SG     
Sbjct: 837  ---------------------APLLQVPPSPPASPTL-QAPRRPPTPGPDTSVSGPRLTL 874

Query: 384  --GPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCAD 441
               PG P         PPS+  +S     +LS  D+       +G      S    L   
Sbjct: 875  ALAPGPPP--------PPSRSPSS-----TLSGPDL-------AGHSSSATSTPEELRGY 914

Query: 442  SLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTAL 501
              G E GAA+    SPP    L++C     S  +GP P +    + A      WP  T  
Sbjct: 915  DSGPEGGAAA----SPPPDAELAACHPAAWS--RGPAPPLA--FRGAPGAPLPWPPATGP 966

Query: 502  GALESLPPPTVGQSPRHHLPQP----EGPPDARETGRCYPLDKGAEGCSAGA--QEPPRA 555
            G+ + L      + P    P P     GP      G      K A G  AGA  + P +A
Sbjct: 967  GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG------KAAAGAGAGASSRSPKQA 1020

Query: 556  SRAEKASQRLAASI 569
               E     L AS+
Sbjct: 1021 RLGELPLGALQASV 1034



 Score = 32.0 bits (71), Expect = 5.0
 Identities = 88/380 (23%), Positives = 115/380 (30%), Gaps = 39/380 (10%)

Query: 259 QGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPP- 317
           Q     L+  PP  P      P     A P LA+P      P+  +P    +P + PPP 
Sbjct: 570 QAPPSPLTTPPPETPSSIATPPP---QAPPALASP------PLQGLPSPPLSPLATPPPQ 620

Query: 318 -PPPLRSDSFAATKSHEKAQGPVFSEAA--AAQHFTALAQAQPRGDRRPELTDRPWRSAH 374
            PP L      A  S   +  P  S  A  + Q   ALA    +    P  +        
Sbjct: 621 APPXLALPPLQAPPSPPAS--PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 678

Query: 375 PGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSD 434
           P +    S     P +A    + PP +   S      +S S    PQ+P     PPL   
Sbjct: 679 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP 738

Query: 435 HSPLCADSLGQE--------PGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQ 486
            SP  +  +           P  A+     PP                Q P       LQ
Sbjct: 739 PSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQ 798

Query: 487 AAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCS 546
           A       +P         SLP   +   P      P+ PP         P    A    
Sbjct: 799 ALPSPPASFPGQAPFSPSASLPMSPLATPP------PQAPPVLAAPLLQVPPSPPASPTL 852

Query: 547 AGAQEPPRASRAEKAS-QRLAASITWADGESSRICPQET---PLL--HSL----TQEGKR 596
              + PP        S  RL  ++           P  T   P L  HS     T E  R
Sbjct: 853 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 912

Query: 597 RPESSPEDSATRPPPFDAHV 616
             +S PE  A   PP DA +
Sbjct: 913 GYDSGPEGGAAASPPPDAEL 932



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 89/364 (24%), Positives = 111/364 (30%), Gaps = 46/364 (12%)

Query: 269 PPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAA 328
           PP  P        P     P  A P      P+  VP    +PS   PP P   S   A 
Sbjct: 360 PPATPPSQAP---PSMTTPPMQAPPSLQTIPPI-QVPHSLTSPSLQAPPSPLALSSLQAT 415

Query: 329 TKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELT--DRPWRSAHPGSLGKGSGGPG 386
           T           S    +   T   QA      RP  T  D P   A P SL      P 
Sbjct: 416 TSLGSPTLQATHSFLTMSPRQT---QASLTSPSRPASTPPDSPPLQA-PLSL------PA 465

Query: 387 CP--QEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLG 444
            P  Q + +    P S       LQA LSS     PQ+P S    P     S L   SL 
Sbjct: 466 SPPLQTSLSPAVSPLSSPLTIHPLQA-LSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQ 524

Query: 445 QEPGA------ASFQNDSPPQVRGLSSCDQKLGSGWQGPRPC-VQGDLQAAQLWAGCWPS 497
             P +       +  + +PP    L +    L +      PC     LQA        P 
Sbjct: 525 TPPASLTTPPLENLPSLAPPP---LQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPP 581

Query: 498 DTALGALESLP--PPTVGQSPRHHLPQP-----EGPPDARETGRCYPLDKGAEGCSAGAQ 550
           +T        P  PP +   P   LP P       PP         P  +      A   
Sbjct: 582 ETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPP 641

Query: 551 EPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPP 610
             P A+ + +A   LA  +  A        P + P            P +SP  S +  P
Sbjct: 642 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF----------SPPASPPVSPSATP 691

Query: 611 PFDA 614
           P  A
Sbjct: 692 PSQA 695


>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
          Length = 278

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 31/79 (39%), Positives = 43/79 (54%), Gaps = 2/79 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSG-FRQ 87
           V ++G APWGF + GGR+   P+++TK+ E  KA   D L  GD IV IN     G    
Sbjct: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 88  EAICLVKGSHKTLKLVVKR 106
           EA   ++ S   L+L + R
Sbjct: 64  EAQSKIRQSPSPLRLQLDR 82


>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
          Length = 366

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 31/79 (39%), Positives = 43/79 (54%), Gaps = 2/79 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSG-FRQ 87
           V ++G APWGF + GGR+   P+++TK+ E  KA   D L  GD IV IN     G    
Sbjct: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 88  EAICLVKGSHKTLKLVVKR 106
           EA   ++ S   L+L + R
Sbjct: 64  EAQSKIRQSPSPLRLQLDR 82



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 59/231 (25%), Positives = 79/231 (34%), Gaps = 24/231 (10%)

Query: 958  EGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPR 1017
            E QS  RQ+ +  R     SQ   P Q   N  +  E+   R       +G  R  T  +
Sbjct: 64   EAQSKIRQSPSPLRLQLDRSQATSPGQT--NGDSSLEVLATRF------QGSVRTYTESQ 115

Query: 1018 DYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRA 1077
                S  S+P  L PRA SP SP         P SS+ L+   A        R  +    
Sbjct: 116  SSLRSSYSSPTSLSPRAGSPFSP---------PPSSSSLTGEAA------ISRSFQSLAC 160

Query: 1078 TDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQ 1137
            + G PA   +   GRP    +        A L L  SP   SS    D+   ++      
Sbjct: 161  SPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDS 220

Query: 1138 HVSGDASRPLPEALLPPKQQHLR-LQTATMETSRSPSPQFAPQKLTDKPPL 1187
             V             P +    R LQ A     R  +P F P  L+ +  L
Sbjct: 221  EVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSL 271


>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
          Length = 352

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 31/79 (39%), Positives = 43/79 (54%), Gaps = 2/79 (2%)

Query: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSG-FRQ 87
           V ++G APWGF + GGR+   P+++TK+ E  KA   D L  GD IV IN     G    
Sbjct: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 88  EAICLVKGSHKTLKLVVKR 106
           EA   ++ S   L+L + R
Sbjct: 64  EAQSKIRQSPSPLRLQLDR 82



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 59/231 (25%), Positives = 79/231 (34%), Gaps = 24/231 (10%)

Query: 958  EGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPR 1017
            E QS  RQ+ +  R     SQ   P Q   N  +  E+   R       +G  R  T  +
Sbjct: 64   EAQSKIRQSPSPLRLQLDRSQATSPGQT--NGDSSLEVLATRF------QGSVRTYTESQ 115

Query: 1018 DYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRA 1077
                S  S+P  L PRA SP SP         P SS+ L+   A        R  +    
Sbjct: 116  SSLRSSYSSPTSLSPRAGSPFSP---------PPSSSSLTGEAA------ISRSFQSLAC 160

Query: 1078 TDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQ 1137
            + G PA   +   GRP    +        A L L  SP   SS    D+   ++      
Sbjct: 161  SPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDS 220

Query: 1138 HVSGDASRPLPEALLPPKQQHLR-LQTATMETSRSPSPQFAPQKLTDKPPL 1187
             V             P +    R LQ A     R  +P F P  L+ +  L
Sbjct: 221  EVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSL 271


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 97/409 (23%), Positives = 142/409 (34%), Gaps = 61/409 (14%)

Query: 905  SLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPR 964
            S DP++  Q     S S PS    + ++    ++Q      P  + P+ V      + P 
Sbjct: 144  SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPG 203

Query: 965  -----------QADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPEL--PREGRGR 1011
                        A A   +GSP + Q P   +AP  P     +H + AP L   R     
Sbjct: 204  TPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPV--PHTHIQQAPALHPQRPPSPH 261

Query: 1012 AGTLPRDYRYSEESTPADLGPRAQSPGSP-LHARGQDSWPVSSALLSKRPAPQRPPPPKR 1070
                P  +   +  T +   P A S   P LH +G    P     L   P  Q P PP+ 
Sbjct: 262  PPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG----PPGPHSLQAGPLLQHPGPPQP 317

Query: 1071 EPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKAT 1130
                 +A+ G    AP+G         SPA+   + + L L  S S   S QP       
Sbjct: 318  FGLPPQASQG---QAPLGT--------SPAAAYPHTS-LQLPASQSALQSQQPPREQPLP 365

Query: 1131 VCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQ 1190
                   H+    + P+P+  LP  Q H      +      PSP      L   P L   
Sbjct: 366  PAPLAMPHIKPPPTTPIPQ--LPAPQAHKHPPHLS-----GPSPFSMNANLPPPPALKPL 418

Query: 1191 DEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTL 1250
               ST       +  +    P++++  +SQP   S      PA+PP L       Q + L
Sbjct: 419  SSLSTH------HPPSAHPPPLQLM-PQSQPLPSS------PAQPPGL------TQSQNL 459

Query: 1251 STSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPP 1299
                  +    L+      P A H   P  P P+    PP     ++PP
Sbjct: 460  PPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPI---TPPTCPSTSTPP 505



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 121/549 (22%), Positives = 180/549 (32%), Gaps = 94/549 (17%)

Query: 167 RTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSS--TPDHTL 224
           RT    +    +   + PS     +  + S++  GS   +D    + STS S  +P    
Sbjct: 109 RTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNE 168

Query: 225 SKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEY 284
           S +D+S+ + +L              Q  A   P G     S  PP  P     GP P  
Sbjct: 169 SDSDSSAQQQMLQA------------QPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSA 216

Query: 285 NAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPP--------------PPPPLRSDSFAATK 330
            A P   +P  S        P++ +AP++P P              PP P          
Sbjct: 217 TAVPPQGSPTASQ------APNQPQAPTAPVPHTHIQQAPALHPQRPPSP-------HPP 263

Query: 331 SHEKAQGPVFSEAAAAQHFTALAQAQP----RGDRRPELTDRPWRSAHPGSLGKGSGGPG 386
            H     P+     +A   +A + AQP    +G   P          HPG   +  G P 
Sbjct: 264 PHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP-PQPFGLPP 322

Query: 387 CPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHP--PLYSDH-SPLCADSL 443
              +  A     P+     + LQ   S S ++  Q P     P  PL   H  P     +
Sbjct: 323 QASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPI 382

Query: 444 GQEP------------GAASFQNDS----PPQVRGLSSCDQKLGSGWQGPRPCVQGDLQA 487
            Q P            G + F  ++    PP ++ LSS           P   +    Q 
Sbjct: 383 PQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQP 442

Query: 488 AQLWAGCWPSDTA----LGALESLPPPTVGQSPR--HHL-PQPEGPPDARETGRCYPLDK 540
                   PS  A    L   ++LPPP     P   H + PQP         G   P+  
Sbjct: 443 L-------PSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITP 495

Query: 541 GAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPES 600
                ++     P  S     S   A+  + A G S   CP  T  +     +    PES
Sbjct: 496 PTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSS---CPLPTVQIKEEALDDAEEPES 552

Query: 601 --------SPEDSATRPPPFDAHVGKPTRRSDR-FATTLRNEI---QMHRAKLQKSRSTV 648
                   SPE +    P   +   +  +  DR + +  R ++    +  +KL K R   
Sbjct: 553 PPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEA 612

Query: 649 ALTAAGEAE 657
              A  EAE
Sbjct: 613 IEKAKREAE 621



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 102/511 (19%), Positives = 161/511 (31%), Gaps = 125/511 (24%)

Query: 913  QHVHGRSRSSPST-DHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCR 971
            + +    R+SPS       ++  E  +++    + +EE  S +++ + Q     +D +  
Sbjct: 50   EDIRSSGRNSPSAASTSSNDSKAETVKKSAK--KVKEEASSPLKSNKRQREKVASDTEEA 107

Query: 972  EGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLG 1031
            + +   +        PN P+  E      +  +  EG      + +D R +  S P+   
Sbjct: 108  DRTSSKKTKTQEISRPNSPSEGE-GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQD 166

Query: 1032 PRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLG 1091
              + S  S      Q   P   A     PAP   PP            G P       L 
Sbjct: 167  NESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP------------GTPQ------LP 208

Query: 1092 RPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEAL 1151
             P PTPS                    ++  PQ +P A+      Q          P A 
Sbjct: 209  TPGPTPSA-------------------TAVPPQGSPTASQAPNQPQ---------APTAP 240

Query: 1152 LPPKQQHLRLQTA-TMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMV 1210
            +P    H  +Q A  +   R PSP   P   +  PPL                       
Sbjct: 241  VP----HTHIQQAPALHPQRPPSPH-PPPHPSPHPPLQ---------------------- 273

Query: 1211 PIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEP 1270
               +  S  QP   S        + P  PH L+                        A P
Sbjct: 274  --PLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQ------------------------AGP 307

Query: 1271 EAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSL 1330
               H   P  PQP G  +PP+  +  +P G S   A   T   L + + A +     +  
Sbjct: 308  LLQH---PGPPQPFG--LPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQ 362

Query: 1331 ----ADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSV 1386
                A +  P +K   T  + +            A Q  K  P +  P         P  
Sbjct: 363  PLPPAPLAMPHIKPPPTTPIPQ----------LPAPQAHKHPPHLSGPSPFSMNANLPPP 412

Query: 1387 PAAVSLATNSTYYSTSA--PKAELLIKMKDL 1415
            PA   L++ ST++  SA  P  +L+ + + L
Sbjct: 413  PALKPLSSLSTHHPPSAHPPPLQLMPQSQPL 443



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 47/183 (25%), Positives = 63/183 (34%), Gaps = 34/183 (18%)

Query: 910  ERPQHVHGRSRSS-----PSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPR 964
            + P H+ G S  S     P     K  +S+           P + +P   +++   S+P 
Sbjct: 392  KHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMP---QSQPLPSSPA 448

Query: 965  QADA--QCREGSPGSQQHPPS---QKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDY 1019
            Q     Q +   P    HPP+   Q AP PP         G P +         T P   
Sbjct: 449  QPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPP------TCP--- 499

Query: 1020 RYSEESTPADLGPRAQSPGSPLHARGQD-----SWP-----VSSALLSKRPAPQRPPPPK 1069
              S  + PA  G  AQ P S   A G       S P     +    L     P+ PPPP 
Sbjct: 500  --STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 557

Query: 1070 REP 1072
            R P
Sbjct: 558  RSP 560


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,625,062
Number of Sequences: 37866
Number of extensions: 4744634
Number of successful extensions: 30022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 1147
Number of HSP's that attempted gapping in prelim test: 22613
Number of HSP's gapped (non-prelim): 7590
length of query: 1616
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1500
effective length of database: 13,855,062
effective search space: 20782593000
effective search space used: 20782593000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press