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Search of human proteins with 37577157
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37577157 calpain 5 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37577157 calpain 5 [Homo sapiens] 1341 0.0
gi|13186316 calpain 6 [Homo sapiens] 599 e-171
gi|27765074 calpain 3 isoform c [Homo sapiens] 383 e-106
gi|4557405 calpain 3 isoform a [Homo sapiens] 361 e-99
gi|27765072 calpain 3 isoform b [Homo sapiens] 361 e-99
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 358 6e-99
gi|221554549 calpain 8 [Homo sapiens] 349 5e-96
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 344 1e-94
gi|12408656 calpain 1, large subunit [Homo sapiens] 337 2e-92
gi|215490104 calpain 11 [Homo sapiens] 333 3e-91
gi|47078247 calpain 3 isoform f [Homo sapiens] 330 3e-90
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 316 5e-86
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 308 1e-83
gi|38707981 calpain 12 [Homo sapiens] 270 2e-72
gi|223468608 calpain 14 [Homo sapiens] 266 6e-71
gi|13186302 calpain 10 isoform a [Homo sapiens] 218 1e-56
gi|41152101 calpain 13 [Homo sapiens] 201 2e-51
gi|89353291 calpain 10 isoform c [Homo sapiens] 198 1e-50
gi|5032105 small optic lobes [Homo sapiens] 146 5e-35
gi|7656959 calpain 7 [Homo sapiens] 117 3e-26
gi|13186314 calpain 10 isoform g [Homo sapiens] 62 1e-09
gi|27765076 calpain 3 isoform d [Homo sapiens] 51 3e-06
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 34 0.36
gi|122937247 unc-13 homolog A [Homo sapiens] 33 0.81
gi|71274172 ankyrin repeat domain 56 [Homo sapiens] 30 5.2
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec... 30 6.8
gi|148727311 hypothetical protein LOC389690 [Homo sapiens] 30 8.9
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 1341 bits (3471), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED 60
MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED
Sbjct: 1 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED 60
Query: 61 PRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGI 120
PRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGI
Sbjct: 61 PRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGI 120
Query: 121 FHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGG 180
FHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGG
Sbjct: 121 FHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGG 180
Query: 181 NTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADM 240
NTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADM
Sbjct: 181 NTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADM 240
Query: 241 EARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSE 300
EARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSE
Sbjct: 241 EARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSE 300
Query: 301 EWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLH 360
EWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLH
Sbjct: 301 EWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLH 360
Query: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGE 420
GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGE
Sbjct: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGE 420
Query: 421 NLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHT 480
NLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHT
Sbjct: 421 NLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHT 480
Query: 481 GEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYV 540
GEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYV
Sbjct: 481 GEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYV 540
Query: 541 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD 600
IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD
Sbjct: 541 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD 600
Query: 601 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV 640
PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
Sbjct: 601 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV 640
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 599 bits (1545), Expect = e-171
Identities = 296/637 (46%), Positives = 416/637 (65%), Gaps = 7/637 (1%)
Query: 5 VKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLF 64
+K +++Q Y L+++C + LF DP F +DSL+Y V WKRP+ IC+DP L
Sbjct: 5 LKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLI 64
Query: 65 VDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFH 124
V IS+H L QG++G+ V+A S LA +ES W K IP+ KEQEWDP+K YAGIFHF
Sbjct: 65 VGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFR 124
Query: 125 FWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTAD 184
FW FGEW +VVIDD LPT+N L++ S S NEFW AL+EKAYAKL GCY+ALDG D
Sbjct: 125 FWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITD 184
Query: 185 ALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARL 244
+VDFTG ++E +D+ +G + ++ +LF + K ++GGLI SI++ + E
Sbjct: 185 IIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVET 244
Query: 245 ACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQK 304
GL+KGH Y +TD+RK+RLG L+ F +EK+ M+RLRNP G +EW+GPWS+ SEEWQ+
Sbjct: 245 DWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQ 304
Query: 305 VSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWT 364
++ S+R+ +G+ + DDGEFWM+ ED CR F + CR +N I E + G WT
Sbjct: 305 LTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNN---PIFGRKELESVLGCWT 361
Query: 365 LHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAI 424
+ +DP NR GGC N++DTF QNPQYIF V + +V++ +QQ+ R+ RR G+ +N I
Sbjct: 362 VDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYII 421
Query: 425 GFDIYKVEENRQYRMHSL--QHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482
GF+++KVE NR++R+H L Q +A +S YI++R+VFL +G YV++PT F+ G T E
Sbjct: 422 GFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSE 481
Query: 483 FLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGL--KDSPTGANSYV 540
FLLR+F++VP REL LD P +CW+ GYP++VTQ+ V A L K + N Y+
Sbjct: 482 FLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYL 541
Query: 541 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD 600
+IKC ++VRS VQK T ++ + IFYR+ PI VQVWN R D+FLGQV L AD
Sbjct: 542 VIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDAD 601
Query: 601 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSL 637
P + + L +L+LR + G ++ ++SS L
Sbjct: 602 PSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDL 638
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 383 bits (983), Expect = e-106
Identities = 210/500 (42%), Positives = 286/500 (57%), Gaps = 46/500 (9%)
Query: 9 EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68
+++ + L + C +KVL+ DP FP + SL+Y WKRP ICE+PR +DG
Sbjct: 57 KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
Query: 69 SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128
+ D+ QG++G+CWF+AA + L + L +VIP D YAGIFHF FWR+
Sbjct: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
Query: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188
GEWVDVVIDD LPT NNQL++ SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
Query: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGL 248
FTGGV+E ++ + + +++ M K RG L+ SI + E R+ACGL
Sbjct: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGL 282
Query: 249 VKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKS 308
V+GHAY+VT + +V FK EK+ ++RLRNPWG+ EWNG WSD ++W V K
Sbjct: 283 VRGHAYSVTGLDEVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKD 334
Query: 309 EREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHE 367
E+ ++ V +DGEFWM++ED +FT + C + + S +TW + G W
Sbjct: 335 EKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV--- 391
Query: 368 DPRQNRGGGCINHKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGK 418
R GGC N DTF+ NPQY + E P+D +IC + Q+ +R R+ G
Sbjct: 392 --RGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG- 448
Query: 419 GENLAIGFDIYKVEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVI 470
IGF IY+V + LQ KA S YIN R V R P YVI
Sbjct: 449 ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVI 508
Query: 471 IPTTFEPGHTGEFLLRVFTD 490
+P+T+EP GEF+LRVF++
Sbjct: 509 VPSTYEPHQEGEFILRVFSE 528
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 361 bits (927), Expect = e-99
Identities = 210/548 (38%), Positives = 287/548 (52%), Gaps = 94/548 (17%)
Query: 9 EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68
+++ + L + C +KVL+ DP FP + SL+Y WKRP ICE+PR +DG
Sbjct: 57 KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
Query: 69 SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128
+ D+ QG++G+CWF+AA + L + L +VIP D YAGIFHF FWR+
Sbjct: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
Query: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188
GEWVDVVIDD LPT NNQL++ SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
Query: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---------------- 232
FTGGV+E ++ + + +++ M K RG L+ SI
Sbjct: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 282
Query: 233 --------------------------------KAVTAADMEARLACGLVKGHAYAVTDVR 260
+ + E R+ACGLV+GHAY+VT +
Sbjct: 283 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 342
Query: 261 KVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDD 320
+V FK EK+ ++RLRNPWG+ EWNG WSD ++W V K E+ ++ V +D
Sbjct: 343 EVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
Query: 321 GEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHEDPRQNRGGGCIN 379
GEFWM++ED +FT + C + + S +TW + G W R GGC N
Sbjct: 395 GEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV-----RGCSAGGCRN 449
Query: 380 HKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGKGENLAIGFDIYK 430
DTF+ NPQY + E P+D +IC + Q+ +R R+ G IGF IY+
Sbjct: 450 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIGFAIYE 508
Query: 431 VEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482
V + LQ KA S YIN R V R P YVI+P+T+EP GE
Sbjct: 509 VPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE 568
Query: 483 FLLRVFTD 490
F+LRVF++
Sbjct: 569 FILRVFSE 576
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 361 bits (927), Expect = e-99
Identities = 210/548 (38%), Positives = 287/548 (52%), Gaps = 94/548 (17%)
Query: 9 EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68
+++ + L + C +KVL+ DP FP + SL+Y WKRP ICE+PR +DG
Sbjct: 57 KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
Query: 69 SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128
+ D+ QG++G+CWF+AA + L + L +VIP D YAGIFHF FWR+
Sbjct: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
Query: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188
GEWVDVVIDD LPT NNQL++ SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
Query: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---------------- 232
FTGGV+E ++ + + +++ M K RG L+ SI
Sbjct: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 282
Query: 233 --------------------------------KAVTAADMEARLACGLVKGHAYAVTDVR 260
+ + E R+ACGLV+GHAY+VT +
Sbjct: 283 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 342
Query: 261 KVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDD 320
+V FK EK+ ++RLRNPWG+ EWNG WSD ++W V K E+ ++ V +D
Sbjct: 343 EVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
Query: 321 GEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHEDPRQNRGGGCIN 379
GEFWM++ED +FT + C + + S +TW + G W R GGC N
Sbjct: 395 GEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV-----RGCSAGGCRN 449
Query: 380 HKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGKGENLAIGFDIYK 430
DTF+ NPQY + E P+D +IC + Q+ +R R+ G IGF IY+
Sbjct: 450 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIGFAIYE 508
Query: 431 VEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482
V + LQ KA S YIN R V R P YVI+P+T+EP GE
Sbjct: 509 VPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE 568
Query: 483 FLLRVFTD 490
F+LRVF++
Sbjct: 569 FILRVFSE 576
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 358 bits (920), Expect = 6e-99
Identities = 199/513 (38%), Positives = 295/513 (57%), Gaps = 50/513 (9%)
Query: 11 QNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISS 70
Q++ +R++C +R LFED FPA++ SL+Y P WKRP I ++P + G +
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
Query: 71 HDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGE 130
D+ QG++G+CW +AA +SL + +VIP ++Q + P YAGIFHF FW+ E
Sbjct: 87 TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGP----GYAGIFHFQFWQHSE 140
Query: 131 WVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFT 190
W+DVVIDDRLPT ++L++ HS NEFW AL+EKAYAKL G Y+AL GG+ +A+ DFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
Query: 191 GGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVK 250
GGV+E F E N +E + K RG L+ I +AA+ EAR GL+K
Sbjct: 201 GGVAE-------TFQTKEAPEN-FYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
Query: 251 GHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSER 310
GHAY+VT + +V F+ +++++IR+RNPWG+ EWNG WSD+S EW+ V +E+
Sbjct: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQ 304
Query: 311 EKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS--HLSIHKTWEEARLHGAWTLHED 368
+++ T DDGEFWM F+D +F + C + + +IHK WE G+W
Sbjct: 305 KRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHK-WEVTVHQGSWV---- 359
Query: 369 PRQNRGGGCINHKDTFFQNPQYIFEVKKPED-----EVLICIQQRPKRSTRREGKGENLA 423
R + GGC N DTF+ NPQ + + ++ L+ + Q+ +R +R G L
Sbjct: 360 -RGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLT 417
Query: 424 IGFDIYKVEENRQ------YRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477
IG+ IY+ + + +R H+ +A S +IN R V R P G Y++IP+TFEP
Sbjct: 418 IGYAIYECPDKDEHLNKDFFRYHA--SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 475
Query: 478 GHTGEFLLRVFTDVPSNCR------ELRLDEPP 504
+F LR+F++ + R ++ L EPP
Sbjct: 476 HQEADFCLRIFSEKKAITRDMDGNVDIDLPEPP 508
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 349 bits (895), Expect = 5e-96
Identities = 205/518 (39%), Positives = 294/518 (56%), Gaps = 57/518 (11%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYK----GTPGP-AVRWKRPKGICEDPR 62
Y Q++ LR+ C VLF+DP FPA +L YK G+P + WKRP +C P+
Sbjct: 27 YLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQ 86
Query: 63 LFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFH 122
V G + D+ QG +G+CW +AA +SL E L +V+P ++Q++ YAGIFH
Sbjct: 87 FIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVP--RDQDFQEN----YAGIFH 140
Query: 123 FHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNT 182
F FW++GEWV+VVIDDRLPT N QL++ HS NEFW AL+EKAYAKL GCY+AL GG+T
Sbjct: 141 FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGST 200
Query: 183 ADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEA 242
+ DFTGG+SE DL + AN L++ + K G L+ SI +AA+ EA
Sbjct: 201 VEGFEDFTGGISEFYDLKKPP-AN-------LYQIIRKALCAGSLLGCSIDVSSAAEAEA 252
Query: 243 RLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEW 302
+ LVK HAY+VT V +V F+ +IRLRNPWGE EW+G WSD + EW
Sbjct: 253 ITSQKLVKSHAYSVTGVEEVN--------FQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304
Query: 303 QKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI--NTSHLSIHKTWEEARLH 360
+ +E++ V +DGEFWM+ D R F+ + C + + S +HK W +
Sbjct: 305 NHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHK-WNLVLFN 362
Query: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPEDE--------VLICIQQRP 409
G WT R + GGC N+ T++ NPQ+ + EV + ++E VL+ + Q+
Sbjct: 363 GHWT-----RGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKN 417
Query: 410 KRSTRREGKGENLAIGFDIYKVEENRQYRMH---------SLQHKAASSIYINSRSVFLR 460
+R +R G+G L+IG+ +Y+V + + + Q A +S Y+N R V R
Sbjct: 418 RRWRKRIGQG-MLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGR 476
Query: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
P G Y+++P+TFEP GEF LRVF++ + E+
Sbjct: 477 ARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEI 514
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 344 bits (883), Expect = 1e-94
Identities = 191/508 (37%), Positives = 286/508 (56%), Gaps = 55/508 (10%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61
Y +Q+Y ALR +C LF+DP FPA +L +K GP + WKRP IC DP
Sbjct: 27 YLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKEL-GPYSSKTRGIEWKRPTEICADP 85
Query: 62 RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121
+ + G + D+ QG +G+CW +AA +SL E + +V+P + YAGIF
Sbjct: 86 QFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP------LNQSFQENYAGIF 139
Query: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181
HF FW++GEWV+VV+DDRLPT + +L++ HS +EFW AL+EKAYAK+ GCY+AL GG
Sbjct: 140 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 199
Query: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241
T + DFTGG++E +L + LF+ + K +G L+ SI +AAD E
Sbjct: 200 TTEGFEDFTGGIAEWYEL--------KKPPPNLFKIIQKALQKGSLLGCSIDITSAADSE 251
Query: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301
A LVKGHAY+VT +V L +KL IR+RNPWGE EW G W+D
Sbjct: 252 AITFQKLVKGHAYSVTGAEEVESNGSL------QKL--IRIRNPWGEVEWTGRWNDNCPS 303
Query: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWEEARLH 360
W + ERE++ +DGEFWM+F D R+++ + C + +T +K W+ ++
Sbjct: 304 WNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362
Query: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE---------VLICIQQRPKR 411
G W R + GGC N+ +TF+ NPQY+ ++++ +++ L+ + Q+ +R
Sbjct: 363 GNWR-----RGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRR 417
Query: 412 STRREGKGENLAIGFDIYKVEE--NRQYRMHSLQH-------KAASSIYINSRSVFLRTD 462
R+ G+ + IGF IY+V E + Q +H ++ + S +IN R V R
Sbjct: 418 RQRKMGEDMH-TIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK 476
Query: 463 QPEGRYVIIPTTFEPGHTGEFLLRVFTD 490
P G Y+++P+TFEP G+F +RVF++
Sbjct: 477 LPPGEYILVPSTFEPNKDGDFCIRVFSE 504
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 337 bits (864), Expect = 2e-92
Identities = 197/518 (38%), Positives = 284/518 (54%), Gaps = 57/518 (11%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61
Y Q+Y LR C + LF D FP SL YK GP ++WKRP + +P
Sbjct: 37 YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDL-GPNSSKTYGIKWKRPTELLSNP 95
Query: 62 RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121
+ VDG + D+ QG +G+CW +AA +SL ++L +V+P + + N YAGIF
Sbjct: 96 QFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQ------NGYAGIF 149
Query: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181
HF W+FGEWVDVV+DD LP + +L++ HS NEFW AL+EKAYAK+ G Y+AL GG+
Sbjct: 150 HFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGS 209
Query: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241
T++ DFTGGV+E +L + + L++ +LK RG L+ SI + DME
Sbjct: 210 TSEGFEDFTGGVTEWYELRKAP--------SDLYQIILKALERGSLLGCSIDISSVLDME 261
Query: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301
A LVKGHAY+VT ++V ++ + + +IR+RNPWGE EW G WSD+S E
Sbjct: 262 AITFKKLVKGHAYSVTGAKQVN--------YRGQVVSLIRMRNPWGEVEWTGAWSDSSSE 313
Query: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLS-IHKTWEEARLH 360
W V ER+++ V + +DGEFWM+F D R FT + C + + S + W
Sbjct: 314 WNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYE 372
Query: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPED--------EVLICIQQRP 409
G W R + GGC N+ TF+ NPQ+ + E P+D ++ + Q+
Sbjct: 373 GTWR-----RGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKH 427
Query: 410 KRSTRREGKGENLAIGFDIYKV--EENRQYRMH-------SLQHKAASSIYINSRSVFLR 460
+R RR G+ + IGF +Y+V E Q +H + +A S +IN R V R
Sbjct: 428 RRRERRFGR-DMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTR 486
Query: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
P G YV++P+TFEP G+F+LR F++ + EL
Sbjct: 487 FRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVEL 524
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 333 bits (854), Expect = 3e-91
Identities = 199/519 (38%), Positives = 290/519 (55%), Gaps = 58/519 (11%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA------VRWKRPKGICEDP 61
+ +Q++ LR C R+ LFEDPLFPA SL +K GP + W+RPK I +P
Sbjct: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDL-GPNSKNVQNISWQRPKDIINNP 119
Query: 62 RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121
+DGIS D+ QG +G+CW +AA SL + L +V+P + Q + K N YAGIF
Sbjct: 120 LFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVP--RGQSF---KKN-YAGIF 173
Query: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181
HF W+FG+WV+VV+DDRLPT N++L++ HS R+EFW AL+EKAYAKL+G Y+AL GG+
Sbjct: 174 HFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGS 233
Query: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241
T + L DFTGGV++ L + L + K R L+ SI+ + +++E
Sbjct: 234 TMEGLEDFTGGVAQSFQL--------QRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELE 285
Query: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301
+ LV+GHAY+VT ++ V ++ + +IR+RNPWG EWNG WSD++ E
Sbjct: 286 SMTDKMLVRGHAYSVTGLQDVH--------YRGKMETLIRVRNPWGRIEWNGAWSDSARE 337
Query: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKT-WEEARLH 360
W++V+ S+ + + +DGEFWM+++D FT + C + + +K+ W
Sbjct: 338 WEEVA-SDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYE 396
Query: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPEDEV---------LICIQQR 408
G+W R + GGC NH TF+ NPQ+ + E PED+ L+ + Q+
Sbjct: 397 GSWR-----RGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQK 451
Query: 409 PKRSTRREGKGENLAIGFDIYKVEENRQ--YRMH-------SLQHKAASSIYINSRSVFL 459
R R++G + IGF +Y V + Q +H Q S I+ NSR V
Sbjct: 452 NWRHARQQG-AQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSS 510
Query: 460 RTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
+ P G Y+IIP+TFEP +FLLRVFT+ S EL
Sbjct: 511 QLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL 549
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 330 bits (845), Expect = 3e-90
Identities = 194/500 (38%), Positives = 262/500 (52%), Gaps = 94/500 (18%)
Query: 57 ICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNA 116
ICE+PR +DG + D+ QG++G+CWF+AA + L + L +VIP D
Sbjct: 18 ICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIEN 71
Query: 117 YAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQA 176
YAGIFHF FWR+GEWVDVVIDD LPT NNQL++ SN RNEFW AL+EKAYAKL G Y+A
Sbjct: 72 YAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEA 131
Query: 177 LDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---- 232
L GGNT +A+ DFTGGV+E ++ + + +++ M K RG L+ SI
Sbjct: 132 LKGGNTTEAMEDFTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGT 183
Query: 233 --------------------------------------------KAVTAADMEARLACGL 248
+ + E R+ACGL
Sbjct: 184 NMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGL 243
Query: 249 VKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKS 308
V+GHAY+VT + +V FK EK+ ++RLRNPWG+ EWNG WSD ++W V K
Sbjct: 244 VRGHAYSVTGLDEVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKD 295
Query: 309 EREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHE 367
E+ ++ V +DGEFWM++ED +FT + C + + S +TW + G W
Sbjct: 296 EKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV--- 352
Query: 368 DPRQNRGGGCINHKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGK 418
R GGC N DTF+ NPQY + E P+D +IC + Q+ +R R+ G
Sbjct: 353 --RGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG- 409
Query: 419 GENLAIGFDIYKVEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVI 470
IGF IY+V + LQ KA S YIN R V R P YVI
Sbjct: 410 ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVI 469
Query: 471 IPTTFEPGHTGEFLLRVFTD 490
+P+T+EP GEF+LRVF++
Sbjct: 470 VPSTYEPHQEGEFILRVFSE 489
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 316 bits (809), Expect = 5e-86
Identities = 187/513 (36%), Positives = 276/513 (53%), Gaps = 76/513 (14%)
Query: 11 QNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISS 70
Q++ +R++C +R LFED FPA++ SL+Y P WKRP I ++P + G +
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
Query: 71 HDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGE 130
D+ QG++G+CW +AA +SL + +VIP ++Q + P YAGIFHF FW+ E
Sbjct: 87 TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGP----GYAGIFHFQFWQHSE 140
Query: 131 WVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFT 190
W+DVVIDDRLPT ++L++ HS NEFW AL+EKAYAKL G Y+AL GG+ +A+ DFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
Query: 191 GGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVK 250
GGV+E F E N +E + K RG L+ I +AA+ EAR GL+K
Sbjct: 201 GGVAE-------TFQTKEAPEN-FYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
Query: 251 GHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSER 310
GHAY+VT + +V F+ +++++IR+RNPWG+ EWNG WSD
Sbjct: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDR------------ 292
Query: 311 EKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS--HLSIHKTWEEARLHGAWTLHED 368
M F+D +F + C + + +IHK WE G+W
Sbjct: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHK-WEVTVHQGSWV---- 333
Query: 369 PRQNRGGGCINHKDTFFQNPQYIFEVKKPED-----EVLICIQQRPKRSTRREGKGENLA 423
R + GGC N DTF+ NPQ + + ++ L+ + Q+ +R +R G L
Sbjct: 334 -RGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLT 391
Query: 424 IGFDIYKVEENRQ------YRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477
IG+ IY+ + + +R H+ +A S +IN R V R P G Y++IP+TFEP
Sbjct: 392 IGYAIYECPDKDEHLNKDFFRYHA--SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449
Query: 478 GHTGEFLLRVFTDVPSNCR------ELRLDEPP 504
+F LR+F++ + R ++ L EPP
Sbjct: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPEPP 482
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 308 bits (789), Expect = 1e-83
Identities = 169/453 (37%), Positives = 257/453 (56%), Gaps = 48/453 (10%)
Query: 57 ICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNA 116
IC DP+ + G + D+ QG +G+CW +AA +SL E + +V+P +
Sbjct: 3 ICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP------LNQSFQEN 56
Query: 117 YAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQA 176
YAGIFHF FW++GEWV+VV+DDRLPT + +L++ HS +EFW AL+EKAYAK+ GCY+A
Sbjct: 57 YAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEA 116
Query: 177 LDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVT 236
L GG T + DFTGG++E +L + LF+ + K +G L+ SI +
Sbjct: 117 LSGGATTEGFEDFTGGIAEWYEL--------KKPPPNLFKIIQKALQKGSLLGCSIDITS 168
Query: 237 AADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWS 296
AAD EA LVKGHAY+VT +V L +KL IR+RNPWGE EW G W+
Sbjct: 169 AADSEAITFQKLVKGHAYSVTGAEEVESNGSL------QKL--IRIRNPWGEVEWTGRWN 220
Query: 297 DTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWE 355
D W + ERE++ +DGEFWM+F D R+++ + C + +T +K W+
Sbjct: 221 DNCPSWNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWK 279
Query: 356 EARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE---------VLICIQ 406
++ G W R + GGC N+ +TF+ NPQY+ ++++ +++ L+ +
Sbjct: 280 LTKMDGNWR-----RGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLI 334
Query: 407 QRPKRSTRREGKGENLAIGFDIYKVEE--NRQYRMHSLQH-------KAASSIYINSRSV 457
Q+ +R R+ G+ + IGF IY+V E + Q +H ++ + S +IN R V
Sbjct: 335 QKHRRRQRKMGEDMH-TIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREV 393
Query: 458 FLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490
R P G Y+++P+TFEP G+F +RVF++
Sbjct: 394 LNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSE 426
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 270 bits (691), Expect = 2e-72
Identities = 175/531 (32%), Positives = 256/531 (48%), Gaps = 83/531 (15%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61
+ Q+Y A+R C +LF DP FPA D+L Y GP V+W RP C +P
Sbjct: 27 FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQL-GPDSEKAKGVKWMRPHEFCAEP 85
Query: 62 RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121
+ + +S D+ QG +GNCWF+AA +SL L ++V+P ++ + + YAG+F
Sbjct: 86 KFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQ------HGYAGVF 139
Query: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181
HF W+FG W+DVV+DDRLP +L++ S RNEFW L+EKAYAKL G Y+ + GG+
Sbjct: 140 HFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGH 199
Query: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241
+A VDFTGGV E + L + LF + ++ L+ A+ + E
Sbjct: 200 MNEAFVDFTGGVGEVLYLRQNSMG--------LFSALRHALAKESLVGATALSDRG---E 248
Query: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301
R GLVKGHAY++T KV LG K+ ++RLRNPWG EW G WSD+
Sbjct: 249 YRTEEGLVKGHAYSITGTHKVFLGF--------TKVRLLRLRNPWGCVEWTGAWSDSCPR 300
Query: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKC----RVINTSHLSIHKTWEEA 357
W + R+ + V ++DGEFWM D +F + C V+ S W
Sbjct: 301 WDTLPTECRDALLVK-KEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEG--GGWHVH 357
Query: 358 RLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE----------------- 400
G W R GG + +TF+ NPQ+ + +P++E
Sbjct: 358 TFQGRWV-----RGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGA 412
Query: 401 -------------VLICIQQRPKRSTRREGKGENLAIGFDIYKVEENR-----QYRMHSL 442
VL+ + QR +R R +G L +GF ++++ E R H+L
Sbjct: 413 RGPARGGRTPKCTVLLSLIQRNRRRLRAKGL-TYLTVGFHVFQIPEELLGLWDSPRSHAL 471
Query: 443 QHK---AASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490
+ A S R V R G Y+++P+T G +F LRVF++
Sbjct: 472 LPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 266 bits (679), Expect = 6e-71
Identities = 172/500 (34%), Positives = 257/500 (51%), Gaps = 56/500 (11%)
Query: 11 QNYSALRRDCRRRKVLFEDPLFPATDDSL----YYKGTPGPAVRWKRPKGICEDPRLFVD 66
Q++ AL +C R LFED FPAT S+ + P P ++WKRP + +P+ +
Sbjct: 28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLP-PRLQWKRPPELHSNPQFYFA 86
Query: 67 GISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFW 126
DL QG VG+CWF+AA +LA + + +V+P + YAGIF F FW
Sbjct: 87 KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVP------LNQSFTEKYAGIFRFWFW 140
Query: 127 RFGEWVDVVIDDRLPTVN-NQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADA 185
+G WV VVIDDRLP QL++ S +N FW AL+EKAYAKL+G Y+ L G ++A
Sbjct: 141 HYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEA 200
Query: 186 LVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLA 245
LVDFTGGV+ I+L E L++ +++ LI + E L
Sbjct: 201 LVDFTGGVTMTINLAEA--------HGNLWDILIEATYNRTLIGCQTHS-----GEKILE 247
Query: 246 CGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKV 305
GLV+GHAY +T +RKV H + E L ++LRNPWG+ EW G WSD+S +W+ +
Sbjct: 248 NGLVEGHAYTLTGIRKVTCKH------RPEYL--VKLRNPWGKVEWKGDWSDSSSKWELL 299
Query: 306 SKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWEEARLHGAWT 364
S E+ + + +DGEFWMT +D +F ++ C++ + W G W
Sbjct: 300 SPKEKILL-LRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRW- 357
Query: 365 LHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPED--------EVLICIQQRPKRSTRRE 416
+ R GG +DTF++NPQ++ V +PE+ VL+ + Q+P+ R+
Sbjct: 358 ---EKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK- 413
Query: 417 GKGENLAIGFDIYKV----EENRQYRMHSLQHKAASS---IYINSRSVFLRTDQPEGRYV 469
+ LAIGF +Y++ ++ R+ Q S ++ + V G Y+
Sbjct: 414 -RKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYL 472
Query: 470 IIPTTFEPGHTGEFLLRVFT 489
I+P E EF+LRVF+
Sbjct: 473 IVPCILEAHQKSEFVLRVFS 492
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 218 bits (555), Expect = 1e-56
Identities = 158/503 (31%), Positives = 236/503 (46%), Gaps = 67/503 (13%)
Query: 26 LFEDPLFPATDDSLYYK-GTPGPAVR----WKRPKGICEDPRLFVDGISSHDLHQGQVGN 80
LF D FPA D SL+ TP R W+RP+ IC PRLF D + QG +G+
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 81 CWFVAACSSLASRESLWQKVIP----DWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVI 136
CWF+ AC++L L +VIP W +QE Y G F W+FG WV+V
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQE--------YRGSFTCRIWQFGRWVEVTT 124
Query: 137 DDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEP 196
DDRLP + +L + + FW L+EK YAK+ G Y+ L G ADALVD TGG++E
Sbjct: 125 DDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAER 184
Query: 197 IDLTEGDFANDETKRNQLFE----RMLKVHSRGGLISASIKAVTAADMEARLACGLVKGH 252
+L + + R +E R L LIS + + A E L + H
Sbjct: 185 WNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFH 238
Query: 253 AYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREK 312
A+ V+D+R+++ G + + ++R++NPWG R W G W + E W +V + +
Sbjct: 239 AFIVSDLRELQGQAG-------QCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASE 291
Query: 313 MGVTVQDDGEFWMTFEDVCRYFTDI-IKCRVINTSHLSIHKT----WEEARLHGAWTLHE 367
+ +Q +GEFW+ E+ R F ++ + V HL T L GAW
Sbjct: 292 LLSQLQ-EGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWV--- 347
Query: 368 DPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENL----- 422
+ GGC N+ F NP++ V +P + + +Q+ + G+ L
Sbjct: 348 --KGQSAGGCRNNSG-FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSH 404
Query: 423 --------------AIGFDIYKVEENRQY--RMHSLQHKAASSIYINSRSVFLRTDQPEG 466
A+G ++KVE+ R R+ S+ A ++ + R V LR + G
Sbjct: 405 TSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPG 464
Query: 467 RYVIIPTTFEPGHTGEFLLRVFT 489
Y+ +P+TF GEFLLRVF+
Sbjct: 465 YYLAVPSTFLKDAPGEFLLRVFS 487
Score = 31.6 bits (70), Expect = 2.3
Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 27/149 (18%)
Query: 354 WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRST 413
W +L G+W + + GG N ++ NP + F V PE C++ +
Sbjct: 514 WGTVQLRGSWRVGQT-----AGGSRNFA-SYPTNPCFPFSV--PEGPGPRCVRITLHQHC 565
Query: 414 RREGKGENLAIGFDIYKVEENRQYR-----------MHSLQHKAASSIYINSRSVFLRTD 462
R E IGF I++V E + + + + H+ A + SR L
Sbjct: 566 RPSDT-EFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEV---SRLCLL--- 618
Query: 463 QPEGRYVIIPTTFEPGHTGEFLLRVFTDV 491
P G Y ++P+T+ P G F + + T +
Sbjct: 619 -PAGTYKVVPSTYLPDTEGAFTVTIATRI 646
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 201 bits (510), Expect = 2e-51
Identities = 157/518 (30%), Positives = 236/518 (45%), Gaps = 76/518 (14%)
Query: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA---VRWKRPKGICEDPRLF 64
++DQ+++ LR C F+D FPA D S+ K V WKRP+ + P F
Sbjct: 16 FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHF 75
Query: 65 V-DGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHF 123
+ D IS D+ QG +CWF+AA SL QK++ Q + + YAGIF F
Sbjct: 76 ILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL---MVQSFSHQ----YAGIFRF 128
Query: 124 HFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRN-EFWCALVEKAYAKLAGCYQALDGGNT 182
FW+ G+WV+VVIDDRLP ++ ++ +N EFW L+EKAYAKL G Y L G
Sbjct: 129 RFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFL 188
Query: 183 ADALVDFTGGV-------SEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAV 235
DALVD TGGV S P+DL + +K ++ G +
Sbjct: 189 EDALVDLTGGVITNIHLHSSPVDLV----------------KAVKTATKAGSLITCATPS 232
Query: 236 TAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNP--WGEREWNG 293
D + GLV HAY VT +++ G ++I L NP WGE EW G
Sbjct: 233 GPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGW--------EEIISLWNPWGWGEAEWRG 284
Query: 294 PWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS---HLSI 350
WSD S+EW++ + ++ ++DGEFWM+ +D + F + C I + ++
Sbjct: 285 RWSDGSQEWEETCDPRKSQLH-KKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTL 343
Query: 351 HKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPED--EVLICIQQR 408
H+ W + L N GG N + Q+ F V++P + V++C+
Sbjct: 344 HEGWSQIMFRKQVIL-----GNTAGGPRN-------DAQFNFSVQEPMEGTNVVVCVTVA 391
Query: 409 PKRSTRREGKGENLAIGFDIYKV-EENRQYR-------MHSLQHKAASSIYINSRSVFLR 460
S K E+ D + ++++R S ++ SS R+ +
Sbjct: 392 VTPSNL---KAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMT 448
Query: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
G YV++ T + EFLLR+F +P + R L
Sbjct: 449 YHLSPGNYVVVAQTRR--KSAEFLLRIFLKMPDSDRHL 484
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 198 bits (504), Expect = 1e-50
Identities = 151/514 (29%), Positives = 231/514 (44%), Gaps = 83/514 (16%)
Query: 26 LFEDPLFPATDDSLYYK-GTPGPAVR----WKRPKGICEDPRLFVDGISSHDLHQGQVGN 80
LF D FPA D SL+ TP R W+RP+ IC PRLF D + QG +G+
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 81 CWFVAACSSLASRESLWQKVIP----DWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVI 136
CWF+ AC++L L +VIP W +QE Y G F W+FG WV+V
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQE--------YRGSFTCRIWQFGRWVEVTT 124
Query: 137 DDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEP 196
DDRLP + +L + + FW L+EK YAK+ G Y+ L G ADALVD TGG++E
Sbjct: 125 DDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAER 184
Query: 197 IDLTEGDFANDETKRNQLFE----RMLKVHSRGGLISASIKAVTAADMEARLACGLVKGH 252
+L + + R +E R L LIS + + A E L + H
Sbjct: 185 WNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFH 238
Query: 253 AYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREK 312
A+ V+D+R+++ G + + ++R++NPWG R W G W + E W +V + +
Sbjct: 239 AFIVSDLRELQGQAG-------QCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASE 291
Query: 313 MGVTVQDDGEFWMTFEDVCRYFTDI-IKCRVINTSHLSIHKT----WEEARLHGAWTLHE 367
+ +Q +GEFW+ E+ R F ++ + V HL T L GAW
Sbjct: 292 LLSQLQ-EGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWV--- 347
Query: 368 DPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENL----- 422
+ GGC N+ F NP++ V +P + + +Q+ + G+ L
Sbjct: 348 --KGQSAGGCRNNSG-FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSH 404
Query: 423 --------------AIGFDIYKVEEN-----------RQYRMHSLQHKAASSIYINSRSV 457
A+G ++KV E ++ + + H+ A + SR
Sbjct: 405 TSWSPASIPGKHYQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEV---SRLC 461
Query: 458 FLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDV 491
L P G Y ++P+T+ P G F + + T +
Sbjct: 462 LL----PAGTYKVVPSTYLPDTEGAFTVTIATRI 491
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 146 bits (369), Expect = 5e-35
Identities = 105/357 (29%), Positives = 151/357 (42%), Gaps = 45/357 (12%)
Query: 20 CRRRKVLFEDPLFPATDDSLYYKGTPGPAVR---WKRPK----GICEDPRL---FVDGIS 69
CR V F D FP +S+ + R W RP+ + D R +
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
Query: 70 SHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFG 129
D+ QG +GNCWF++A + LA R L ++V+ + G + + G
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVT---------RSLCAEGAYQVRLCKDG 591
Query: 130 EWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDF 189
W V++DD LP + R + W AL+EKA AKL G Y AL G + L
Sbjct: 592 TWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATL 651
Query: 190 TGGVSE--PIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVT-AADMEARLAC 246
TG E + L+ + + + ++ +ML G L+ AS D A +
Sbjct: 652 TGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESL 711
Query: 247 GLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVS 306
GL HAY++ DVR V + ++RLRNPWG WNG WSD W
Sbjct: 712 GLRPRHAYSILDVRDV------------QGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHL 759
Query: 307 KSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAW 363
+ E G +G FWM + D RYF + C+V H W+EAR+ G +
Sbjct: 760 RGELMPHG---SSEGVFWMEYGDFVRYFDSVDICKV--------HSDWQEARVQGCF 805
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 117 bits (293), Expect = 3e-26
Identities = 109/406 (26%), Positives = 179/406 (44%), Gaps = 64/406 (15%)
Query: 50 RWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQK------VIPD 103
+W RP+ + +P + +SS + Q V +C FVA+ + A+ E + K + P
Sbjct: 260 KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318
Query: 104 WKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC-HSNSRNEFWCAL 162
K+ E + Y H + G V+IDD+LP + + C +SN+++E W +L
Sbjct: 319 NKDGEPEYNPCGKYMVKLHLN----GVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSL 374
Query: 163 VEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGD--FANDETKRNQLFERMLK 220
+EKAY K+ G Y G N+ L TG + E I + F+ D + R L++R
Sbjct: 375 IEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFR-MLYQRF-- 430
Query: 221 VHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMI 280
H LI+AS +T A+ E GLV HAYAV D+R+ FK L I
Sbjct: 431 -HKGDVLITASTGMMTEAEGE---KWGLVPTHAYAVLDIRE----------FKG--LRFI 474
Query: 281 RLRNPWGEREWNGPWSDTS-EEWQKVSKSEREKMGVTVQ--DDGEFWMTFEDVCRYFTDI 337
+L+NPW W G +S+ + W + T Q D+G FW++++D+C+Y+ D+
Sbjct: 475 QLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYY-DV 533
Query: 338 IKCRVINTSHLSIHKTW------EEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYI 391
I+ +W E +H W + P + + NPQY
Sbjct: 534 ------------IYLSWNPGLFKESTCIHSTWDAKQGP--------VKDAYSLANNPQYK 573
Query: 392 FEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQY 437
EV+ P+ + + + + + I +YK + + Y
Sbjct: 574 LEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVY 619
Score = 39.7 bits (91), Expect = 0.009
Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 19/142 (13%)
Query: 358 RLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREG 417
R++G W+ GGC N ++T NP Y F ++K + I+ R R
Sbjct: 691 RINGKWS------GQSAGGCGNFQETHKNNPIYQFHIEKTGP---LLIELRGPRQ----- 736
Query: 418 KGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477
++GF++ V H K++ + L + P G + IIP+TF P
Sbjct: 737 ----YSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELE-NIPSGIFNIIPSTFLP 791
Query: 478 GHTGEFLLRVFTDVPSNCRELR 499
G F L + +P +L+
Sbjct: 792 KQEGPFFLDFNSIIPIKITQLQ 813
>gi|13186314 calpain 10 isoform g [Homo sapiens]
Length = 139
Score = 62.4 bits (150), Expect = 1e-09
Identities = 37/90 (41%), Positives = 47/90 (52%), Gaps = 6/90 (6%)
Query: 26 LFEDPLFPATDDSLYYK-GTPGPAVR----WKRPKGICEDPRLFVDGISSHDLHQGQVGN 80
LF D FPA D SL+ TP R W+RP+ IC PRLF D + QG +G+
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 81 CWFVAACSSL-ASRESLWQKVIPDWKEQEW 109
CWF+ AC++L SR L Q P +W
Sbjct: 73 CWFLCACAALQKSRHLLDQVSCPVQLPADW 102
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 51.2 bits (121), Expect = 3e-06
Identities = 24/46 (52%), Positives = 30/46 (65%)
Query: 445 KAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490
KA S YIN R V R P YVI+P+T+EP GEF+LRVF++
Sbjct: 19 KARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSE 64
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 34.3 bits (77), Expect = 0.36
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 11/110 (10%)
Query: 500 LDEPPHTCWSSLCGY--PQLVTQVHVLGAAGL--KDSPTG------ANSYVIIKCEGDKV 549
+D PP C ++ + V ++HVL A L KD G ++ YV +K G
Sbjct: 628 VDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSF 687
Query: 550 RSAVQKGTSTPEYN-VKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLK 598
RS V + P +N V + Q + V+V++ + KD+FLG+ ++
Sbjct: 688 RSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVR 737
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 33.1 bits (74), Expect = 0.81
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 537 NSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQV 595
N+YV +K + K + +G S P + +F +L +TV+VWN ++ D +G V
Sbjct: 109 NTYVTLKVQNVKSTTIAVRG-SQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTV 166
>gi|71274172 ankyrin repeat domain 56 [Homo sapiens]
Length = 793
Score = 30.4 bits (67), Expect = 5.2
Identities = 22/79 (27%), Positives = 35/79 (44%), Gaps = 9/79 (11%)
Query: 227 LISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGH-GLLAFFKSEKLDMIRLRNP 285
L+S + KA D+ R +CG H A+ GH G++ + +R+
Sbjct: 650 LVSGAKKAGIVLDVNVRSSCGYTPLHLAAIH-------GHQGVIKLLVQRLASRVNVRDS 702
Query: 286 WGEREWNGPWSDTSEE-WQ 303
G++ W S+TS E WQ
Sbjct: 703 SGKKPWQYLTSNTSGEIWQ 721
>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
precursor [Homo sapiens]
Length = 627
Score = 30.0 bits (66), Expect = 6.8
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 6/73 (8%)
Query: 226 GLISASIKAVTAADMEARLACGLVKGH------AYAVTDVRKVRLGHGLLAFFKSEKLDM 279
GL+ AS T A E RL L G+ ++DV VR G + ++ +
Sbjct: 22 GLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQ 81
Query: 280 IRLRNPWGEREWN 292
+ N W ++EW+
Sbjct: 82 MMTTNVWVKQEWH 94
>gi|148727311 hypothetical protein LOC389690 [Homo sapiens]
Length = 1318
Score = 29.6 bits (65), Expect = 8.9
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 13/64 (20%)
Query: 63 LFVDGI--SSHDLHQGQVGNCW----FVAACSSLA-------SRESLWQKVIPDWKEQEW 109
L+V G+ SS +L + CW A S+ S+E LW P W +QE
Sbjct: 223 LYVMGVLSSSEELFSQEDKACWEEQLIQMAIKSVPFLSTDVWSKELLWTLTTPSWTQQEQ 282
Query: 110 DPEK 113
PEK
Sbjct: 283 SPEK 286
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,191,387
Number of Sequences: 37866
Number of extensions: 1313220
Number of successful extensions: 2692
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2554
Number of HSP's gapped (non-prelim): 35
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.