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Search of human proteins with 239752520
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239752520 PREDICTED: similar to Rap guanine nucleotide
exchange factor 2, partial [Homo sapiens]
(803 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 1586 0.0
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 1586 0.0
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 1181 0.0
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 126 7e-29
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 126 7e-29
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 126 7e-29
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 107 6e-23
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 107 6e-23
gi|13376349 PDZ domain containing 7 [Homo sapiens] 73 1e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 70 1e-11
gi|7706025 PDZ domain containing 11 [Homo sapiens] 61 5e-09
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 60 1e-08
gi|41281808 harmonin isoform b3 [Homo sapiens] 52 2e-06
gi|71480164 harmonin isoform a [Homo sapiens] 52 2e-06
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 52 3e-06
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 51 4e-06
gi|11545920 lin-7 homolog B [Homo sapiens] 49 1e-05
gi|8922944 lin-7 homolog C [Homo sapiens] 48 4e-05
gi|21361142 PDZ domain containing 1 [Homo sapiens] 47 9e-05
gi|4759306 lin-7 homolog A [Homo sapiens] 47 9e-05
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 46 2e-04
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 46 2e-04
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 45 2e-04
gi|10092691 tight junction protein 3 [Homo sapiens] 45 3e-04
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 44 6e-04
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 44 6e-04
gi|55749523 syntenin isoform 3 [Homo sapiens] 42 0.002
gi|55749515 syntenin isoform 3 [Homo sapiens] 42 0.002
gi|55749504 syntenin isoform 2 [Homo sapiens] 42 0.002
gi|55749490 syntenin isoform 1 [Homo sapiens] 42 0.002
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 1586 bits (4106), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
Sbjct: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
Query: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
Sbjct: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
Query: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
Sbjct: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
Query: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
Sbjct: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
Query: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
Sbjct: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
Query: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
Sbjct: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
Query: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
Sbjct: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
Query: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
Sbjct: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
Query: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
Sbjct: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
Query: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
Sbjct: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
Query: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
Sbjct: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
Query: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
Sbjct: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
Query: 781 QLKRMKIIKHFIKIALHCRECKN 803
QLKRMKIIKHFIKIALHCRECKN
Sbjct: 781 QLKRMKIIKHFIKIALHCRECKN 803
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 1586 bits (4106), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
Sbjct: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
Query: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
Sbjct: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
Query: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
Sbjct: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
Query: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
Sbjct: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
Query: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
Sbjct: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
Query: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
Sbjct: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
Query: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
Sbjct: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
Query: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
Sbjct: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
Query: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
Sbjct: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
Query: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
Sbjct: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
Query: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
Sbjct: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
Query: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
Sbjct: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
Query: 781 QLKRMKIIKHFIKIALHCRECKN 803
QLKRMKIIKHFIKIALHCRECKN
Sbjct: 781 QLKRMKIIKHFIKIALHCRECKN 803
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 1181 bits (3056), Expect = 0.0
Identities = 591/785 (75%), Positives = 678/785 (86%), Gaps = 4/785 (0%)
Query: 20 SLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLP 79
SLPAD TK+HLT++ HPQVTHVSSS SGCSI SDSGSSSLSDIYQATESE GD+DL+ LP
Sbjct: 165 SLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLP 224
Query: 80 ETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANM 139
E VDSEDD++E++ +DPL RD+VR+CLEK+P D+TDDDIEQLLEFMHQLPAFANM
Sbjct: 225 EGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANM 284
Query: 140 TMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSF 199
TMSVRRELC+VM+F VVE+AG I+L DG+ELDSW VILNG+VE+++PDGK E L MGNSF
Sbjct: 285 TMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSF 344
Query: 200 GVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRE 259
G++PT+DK+YM G++RTKVDDCQFVCIAQQDY RILN VEKN KVEEEGEIVMV EHRE
Sbjct: 345 GITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRE 404
Query: 260 LDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEW 319
LDR+GTRKGHIVIK T ERL MHL+EEHS+VDPT+IEDFLLTYRTFL SP++VG KLLEW
Sbjct: 405 LDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEW 464
Query: 320 FNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAA 379
F SLRDKVTR+VLLWVNNHFNDFEGDPAMTRFLEEFE NLE KM GHLRLLNIACAA
Sbjct: 465 FKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAA 524
Query: 380 KAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQ 439
KAK R + L K SRE+PL F L GGSEKGFGIFV+ V+ GSKA ++GLKRGDQI+EVNGQ
Sbjct: 525 KAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQ 584
Query: 440 NFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASR 499
NFENI KA+EILRNNTHL++TVKTN+FVFKELL R +E++++G PH+PKI + KK++R
Sbjct: 585 NFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFR-TEQEKSGVPHIPKIAE-KKSNR 642
Query: 500 YSIPDLAVDVEQVIGLEKVNKKSKANTV-GGRNKLKKILDKTRISILPQKPYNDIGIGQS 558
+SI + D+EQ EK +KK KANTV GGRNK++KILDKTR SILP K ++D G+ QS
Sbjct: 643 HSIQHVPGDIEQT-SQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQS 701
Query: 559 QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQ 618
QDDSIVG R +H +P+ GTLSSS+PDLLQ +LDFS D+PDQV+RVFK DQQ
Sbjct: 702 QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQ 761
Query: 619 SRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADR 678
S YI+ISKDTTAKEVV A+ EF +T D YSLCEVSVTPEGVIKQRRLPDQ SKLADR
Sbjct: 762 SCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADR 821
Query: 679 IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP 738
IQL+GRYYLKNNMETETLCSDEDAQEL++ESQ+S+LQLST+EVATQLSMR+F+LFRNIEP
Sbjct: 822 IQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEP 881
Query: 739 TEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC 798
TEYIDDLFKL SKT +LKRFE+++NQETFWVASEIL E NQLKRMKIIKHFIKIALHC
Sbjct: 882 TEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHC 941
Query: 799 RECKN 803
RECKN
Sbjct: 942 RECKN 946
Score = 32.0 bits (71), Expect = 2.3
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 108 RDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVER-AGTIVLND 166
R L K P +RT +D+ + ++H + +N+ +L + A ER +G VL
Sbjct: 10 RQALRKKPPERTPEDLNTIYSYLHGMEILSNLR---EHQLRLMSARARYERYSGNQVLFC 66
Query: 167 GEEL-DSWSVILNGSVEV 183
E + W ++L+GSV V
Sbjct: 67 SETIARCWYILLSGSVLV 84
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 126 bits (317), Expect = 7e-29
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 5/174 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN
Sbjct: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKN 708
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 126 bits (317), Expect = 7e-29
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 5/174 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN
Sbjct: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKN 708
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 126 bits (317), Expect = 7e-29
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 198 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 257
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 258 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 317
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 318 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 377
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 378 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 437
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 438 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 497
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 498 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 548
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 5/174 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 578 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 637
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 638 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 697
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN
Sbjct: 698 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKN 750
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 107 bits (266), Expect = 6e-23
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
Query: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
Query: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
Query: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 335 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 394
Query: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
F+ + + + PS + +V R+VL W + + + D
Sbjct: 395 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 454
Query: 351 TRFLEEF 357
FLEEF
Sbjct: 455 MAFLEEF 461
Score = 58.9 bits (141), Expect = 2e-08
Identities = 33/89 (37%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Query: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
Query: 775 ILRETNQLKRMKIIKHFIKIALHCRECKN 803
I + KR++++K FIKIA HC+E KN
Sbjct: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKN 715
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 107 bits (266), Expect = 6e-23
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 299 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 358
Query: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 359 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 418
Query: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 419 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 478
Query: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 479 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 538
Query: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
F+ + + + PS + +V R+VL W + + + D
Sbjct: 539 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 598
Query: 351 TRFLEEF 357
FLEEF
Sbjct: 599 MAFLEEF 605
Score = 58.9 bits (141), Expect = 2e-08
Identities = 33/89 (37%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Query: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 775 ILRETNQLKRMKIIKHFIKIALHCRECKN 803
I + KR++++K FIKIA HC+E KN
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKN 859
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/129 (22%), Positives = 64/129 (49%), Gaps = 10/129 (7%)
Query: 110 CLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEE 169
CL+K P++R+ +D++ + + ++ AF ++ ++C + +E+ G + G+
Sbjct: 18 CLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEK-GITLFRQGDI 76
Query: 170 LDSWSVILNGSVEV----TYPDGKAEILC---MGNSFGVSPTMDKEYMKGVMRTKVDDCQ 222
+W +L GS++V T A +C +G +FG S +D + T+ + +
Sbjct: 77 GTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGES-ILDNTPRHATIVTR-ESSE 134
Query: 223 FVCIAQQDY 231
+ I Q+D+
Sbjct: 135 LLRIEQKDF 143
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 72.8 bits (177), Expect = 1e-12
Identities = 36/82 (43%), Positives = 52/82 (63%)
Query: 383 RRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFE 442
RR++ L S + L F + GG E G GI+V VD G A E G+K GDQ+L NG F+
Sbjct: 208 RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFD 267
Query: 443 NIQLSKAMEILRNNTHLSITVK 464
+I S+A+E+L+ TH+ +T+K
Sbjct: 268 DISHSQAVEVLKGQTHIMLTIK 289
Score = 60.1 bits (144), Expect = 8e-09
Identities = 30/68 (44%), Positives = 44/68 (64%)
Query: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
L F + GGSE G GIFV V+ GS A AGL GD+I EVNG + E+ + A+++L ++
Sbjct: 97 LGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSS 156
Query: 457 THLSITVK 464
+ L + V+
Sbjct: 157 SRLHMMVR 164
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/68 (50%), Positives = 49/68 (72%)
Query: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
L + GG+E G GI++ VD GS+A +GLK GDQILEVNG++F NI +A+ +L+++
Sbjct: 290 LGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
Query: 457 THLSITVK 464
HL +TVK
Sbjct: 350 RHLILTVK 357
Score = 57.8 bits (138), Expect = 4e-08
Identities = 31/86 (36%), Positives = 51/86 (59%)
Query: 378 AAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVN 437
A + RL++L + L F + GGSE G GI+V V+ GS A + GL+ GDQIL VN
Sbjct: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
Query: 438 GQNFENIQLSKAMEILRNNTHLSITV 463
++ + ++A++ L+ + L ++V
Sbjct: 193 DKSLARVTHAEAVKALKGSKKLVLSV 218
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 60.8 bits (146), Expect = 5e-09
Identities = 35/81 (43%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 384 RLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFEN 443
R +TL KP A L F + GG GIF+ V S A AGL+ GDQ+L VN +F++
Sbjct: 46 RTITLKKPPG-AQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
Query: 444 IQLSKAMEILRNNTHLSITVK 464
I+ SKA+EIL+ +S+ V+
Sbjct: 105 IEHSKAVEILKTAREISMRVR 125
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/165 (30%), Positives = 85/165 (51%), Gaps = 7/165 (4%)
Query: 643 VTATPDQYS---LCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSD 699
V A QY+ L V++T G K P+ L ++ ++ SGR Y+ +TL
Sbjct: 421 VVAEKIQYAEEDLALVAITFSGE-KHELQPNDLV-ISKSLEASGRIYVYRKDLADTLNPF 478
Query: 700 EDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLR-SKTSCANLK 758
+ +E + S + +L ++T ++A +L ++ LF +I E I F + S ANL
Sbjct: 479 AENEESQQRS-MRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLS 537
Query: 759 RFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
+ N+ WVA+EIL + KR++++K FIKIA HC+ +N
Sbjct: 538 LLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRN 582
Score = 41.2 bits (95), Expect = 0.004
Identities = 53/260 (20%), Positives = 106/260 (40%), Gaps = 60/260 (23%)
Query: 139 MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS 198
+T +V+REL AV+ +A + EE + V + + V PD +A ++C
Sbjct: 93 LTSAVQRELAAVIAL----KARKSAIEQDEENNDKHVAVTEAESV--PDSQAGVMC---- 142
Query: 199 FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR 258
K R ++ + V ++ + L +K +K E + + V + +
Sbjct: 143 ------------KLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
Query: 259 ELDRT----------------GTRKGH---IVIKGTSERLTMHLVEEHSVVD------PT 293
E D++ G+ + H +V+ GT E++ HL+ + + + T
Sbjct: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
Query: 294 FIEDFLLTYRTFLSSPMEVGKKLLEWFND------------PSLRDKVTRVVLLWVNNHF 341
++DFLLTY F+++ ++ + LL ++ P + KV +V W+ +
Sbjct: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
Query: 342 NDFEGDPAMTRFLEEFENNL 361
+ D FL+ N+
Sbjct: 310 DWLPEDEHSKMFLKTIYRNV 329
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/54 (42%), Positives = 38/54 (70%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITV 463
GIF+ V GS + E GL+ GDQI+EVNG +F N+ +A+ +L+++ L+I++
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISI 288
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/62 (30%), Positives = 35/62 (56%)
Query: 403 GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSIT 462
GG E G G+F+ + G +A GL+ GD+I+ +NG + + + + ++R +SI
Sbjct: 104 GGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIK 163
Query: 463 VK 464
V+
Sbjct: 164 VR 165
Score = 30.8 bits (68), Expect = 5.2
Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 388 LTKPSREAPLPFILLGGSEKGFGIFVDSV--DSGSKATEAGLKRGDQILEVNGQNFENIQ 445
L + +E L L GG + G V S + G+ G+ +GD+I+ +NG+ +
Sbjct: 755 LLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYT 814
Query: 446 LSKAMEILR 454
L++A L+
Sbjct: 815 LAEAEAALQ 823
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/54 (42%), Positives = 38/54 (70%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITV 463
GIF+ V GS + E GL+ GDQI+EVNG +F N+ +A+ +L+++ L+I++
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISI 288
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/62 (30%), Positives = 35/62 (56%)
Query: 403 GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSIT 462
GG E G G+F+ + G +A GL+ GD+I+ +NG + + + + ++R +SI
Sbjct: 104 GGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIK 163
Query: 463 VK 464
V+
Sbjct: 164 VR 165
Score = 30.8 bits (68), Expect = 5.2
Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 388 LTKPSREAPLPFILLGGSEKGFGIFVDSV--DSGSKATEAGLKRGDQILEVNGQNFENIQ 445
L + +E L L GG + G V S + G+ G+ +GD+I+ +NG+ +
Sbjct: 455 LLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYT 514
Query: 446 LSKAMEILR 454
L++A L+
Sbjct: 515 LAEAEAALQ 523
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/82 (35%), Positives = 49/82 (59%), Gaps = 1/82 (1%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFK-LRSKTSCANLKRFEEVINQETFWVASEILRE 778
+VA L+ ++ELFR + E++D +F R + ANL+ + ++ T WVA+E+L
Sbjct: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
Query: 779 TNQLKRMKIIKHFIKIALHCRE 800
KR +++K FIKIA C++
Sbjct: 281 EAPGKRAQLLKKFIKIAALCKQ 302
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
+L+++ E A+Q+++ + +F+ I+P E + + K S A N+ F NQ +FWV
Sbjct: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
EIL R +I+ HF+KIA E N
Sbjct: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNN 137
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 49.3 bits (116), Expect = 1e-05
Identities = 27/65 (41%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 391 PSREAPLPFILLGGSEKGFGIFVDSVDSGSKATE-AGLKRGDQILEVNGQNFENIQLSKA 449
P + L F ++GG E+ I++ V G A GLKRGDQ+L VNG + E Q KA
Sbjct: 97 PKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKA 156
Query: 450 MEILR 454
+E+L+
Sbjct: 157 VELLK 161
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/65 (40%), Positives = 37/65 (56%), Gaps = 1/65 (1%)
Query: 391 PSREAPLPFILLGGSEKGFGIFVDSVDSGSKATE-AGLKRGDQILEVNGQNFENIQLSKA 449
P E L F ++GG E+ I++ + G A GLKRGDQ+L VNG + E KA
Sbjct: 97 PKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKA 156
Query: 450 MEILR 454
+E+L+
Sbjct: 157 VELLK 161
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 46.6 bits (109), Expect = 9e-05
Identities = 33/95 (34%), Positives = 48/95 (50%), Gaps = 9/95 (9%)
Query: 399 FILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILR---N 455
F L GSE+ G + +DSGS A EAGLK D ++ VNG++ E + +E++R +
Sbjct: 255 FYLRAGSEQK-GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGD 313
Query: 456 NTHLSITVKT-----NLFVFKELLTRLSEEKRNGA 485
T L + K L F L S+E NG+
Sbjct: 314 QTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGS 348
Score = 37.4 bits (85), Expect = 0.056
Identities = 23/94 (24%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFV 469
G+++ + A AG+ D ++EVNG+N E+ + +E ++ + + + +
Sbjct: 157 GVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET 216
Query: 470 FKELLTRLSEEKRNGA-----PHLPKIGDIKKAS 498
K + + + KR A PH P+I ++KK S
Sbjct: 217 DKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGS 250
Score = 31.2 bits (69), Expect = 4.0
Identities = 16/47 (34%), Positives = 26/47 (55%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
G F+ V G A AGL+ D I+EVNG N + K ++ ++++
Sbjct: 400 GSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSS 446
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 46.6 bits (109), Expect = 9e-05
Identities = 25/65 (38%), Positives = 37/65 (56%), Gaps = 1/65 (1%)
Query: 391 PSREAPLPFILLGGSEKGFGIFVDSVDSGSKATE-AGLKRGDQILEVNGQNFENIQLSKA 449
P + L F ++GG E+ I++ + G A GLKRGDQ+L VNG + E KA
Sbjct: 112 PKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKA 171
Query: 450 MEILR 454
+E+L+
Sbjct: 172 VELLK 176
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 1/84 (1%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRET 779
E+A QL++ + ELF IE E + K +++ NL +F E N ++WV S I+ +
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL-WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQE 919
Query: 780 NQLKRMKIIKHFIKIALHCRECKN 803
R +++ FIKI H R+ N
Sbjct: 920 KAQDRERLLLKFIKIMKHLRKLNN 943
Score = 32.7 bits (73), Expect = 1.4
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 6/76 (7%)
Query: 246 EEEGEIVMVKEHRELDRTGTRK-----GHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
EEE + + + +H E+ T K G V G+ + L +H E + E FL
Sbjct: 680 EEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLT 739
Query: 301 TYRTFLSSPMEVGKKL 316
TYRTF+ SP E+ KKL
Sbjct: 740 TYRTFI-SPEELIKKL 754
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 1/84 (1%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRET 779
E+A QL++ + ELF IE E + K +++ NL +F E N ++WV S I+ +
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL-WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQE 901
Query: 780 NQLKRMKIIKHFIKIALHCRECKN 803
R +++ FIKI H R+ N
Sbjct: 902 KAQDRERLLLKFIKIMKHLRKLNN 925
Score = 32.7 bits (73), Expect = 1.4
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 6/76 (7%)
Query: 246 EEEGEIVMVKEHRELDRTGTRK-----GHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
EEE + + + +H E+ T K G V G+ + L +H E + E FL
Sbjct: 662 EEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLT 721
Query: 301 TYRTFLSSPMEVGKKL 316
TYRTF+ SP E+ KKL
Sbjct: 722 TYRTFI-SPEELIKKL 736
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/138 (26%), Positives = 55/138 (39%), Gaps = 33/138 (23%)
Query: 261 DRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF 320
D +R G +IKG + + + H DP F+ FL TYR+F P E+ L+E F
Sbjct: 588 DNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCK-PQELLSLLIERF 646
Query: 321 N----DPSLRDK----------------------------VTRVVLLWVNNHFNDFEGDP 348
+P+ DK + V WV +HF DFE D
Sbjct: 647 EIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDL 706
Query: 349 AMTRFLEEFENNLEREKM 366
+ LE F +++ + M
Sbjct: 707 ELLERLESFISSVRGKAM 724
Score = 37.4 bits (85), Expect = 0.056
Identities = 20/83 (24%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK-TSCANLKRFEEVINQETFWV 771
L+ L +E+A QL++ +L+R ++P+E + ++ K + NL + T W
Sbjct: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833
Query: 772 ASEILRETNQLKRMKIIKHFIKI 794
I+ N +R+ ++ I+I
Sbjct: 834 EKCIVEAENFEERVAVLSRIIEI 856
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/53 (43%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 401 LLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEIL 453
L GG++ GIFV V +GS A G++ GDQIL+VN F+N+ +A++ L
Sbjct: 429 LAGGND--VGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFL 479
Score = 36.6 bits (83), Expect = 0.095
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 404 GSEKGFGIFVDSV-DSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
G + G IF+ + DSG A GL+ GD IL++NG + +N+ L+ ++ +
Sbjct: 226 GVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKS 279
Score = 35.0 bits (79), Expect = 0.28
Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 2/79 (2%)
Query: 387 TLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQL 446
TL+K R I G G + V V G A E L+ GD I+ VNG + EN
Sbjct: 32 TLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA-EGRLQTGDHIVMVNGVSMENATS 90
Query: 447 SKAMEILRNNTHL-SITVK 464
+ A++IL+ T + +ITVK
Sbjct: 91 AFAIQILKTCTKMANITVK 109
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/97 (29%), Positives = 55/97 (56%), Gaps = 7/97 (7%)
Query: 397 LPFILLGGSEKGF-----GIFVDSV-DSGSKATEAGLKRGDQILEVNGQNFENIQLSKAM 450
L F ++GG+++ + GI+V + ++G+ A + L+ GD+IL VNGQ+ +N+ A+
Sbjct: 23 LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAV 82
Query: 451 EILRNNTH-LSITVKTNLFVFKELLTRLSEEKRNGAP 486
++ RN + +S+ V+ L V + E +G P
Sbjct: 83 DLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIP 119
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
+L+++ E A Q+++ + +F+ I+P E + + K S A N F N +FWV
Sbjct: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
EIL R +++ H+IK A E N
Sbjct: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNN 136
>gi|55749523 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/66 (34%), Positives = 36/66 (54%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFV 469
GIFV V + S A+ GL+ GDQ+L++NG+N KA ++L+ IT+
Sbjct: 134 GIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRP 193
Query: 470 FKELLT 475
F+ +T
Sbjct: 194 FERTIT 199
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 413 VDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEIL-RNNTHLSITVKTNLFVFK 471
+ S+ S A GL I E+NGQN ++ S+ +IL + T ++IT+ F+F+
Sbjct: 217 ITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMP-AFIFE 275
Query: 472 ELLTRLS 478
++ R++
Sbjct: 276 HIIKRMA 282
>gi|55749515 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/66 (34%), Positives = 36/66 (54%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFV 469
GIFV V + S A+ GL+ GDQ+L++NG+N KA ++L+ IT+
Sbjct: 134 GIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRP 193
Query: 470 FKELLT 475
F+ +T
Sbjct: 194 FERTIT 199
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 413 VDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEIL-RNNTHLSITVKTNLFVFK 471
+ S+ S A GL I E+NGQN ++ S+ +IL + T ++IT+ F+F+
Sbjct: 217 ITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMP-AFIFE 275
Query: 472 ELLTRLS 478
++ R++
Sbjct: 276 HIIKRMA 282
>gi|55749504 syntenin isoform 2 [Homo sapiens]
Length = 292
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/66 (34%), Positives = 36/66 (54%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFV 469
GIFV V + S A+ GL+ GDQ+L++NG+N KA ++L+ IT+
Sbjct: 129 GIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRP 188
Query: 470 FKELLT 475
F+ +T
Sbjct: 189 FERTIT 194
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 413 VDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEIL-RNNTHLSITVKTNLFVFK 471
+ S+ S A GL I E+NGQN ++ S+ +IL + T ++IT+ F+F+
Sbjct: 212 ITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMP-AFIFE 270
Query: 472 ELLTRLS 478
++ R++
Sbjct: 271 HIIKRMA 277
>gi|55749490 syntenin isoform 1 [Homo sapiens]
Length = 298
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/66 (34%), Positives = 36/66 (54%)
Query: 410 GIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFV 469
GIFV V + S A+ GL+ GDQ+L++NG+N KA ++L+ IT+
Sbjct: 135 GIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRP 194
Query: 470 FKELLT 475
F+ +T
Sbjct: 195 FERTIT 200
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 413 VDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEIL-RNNTHLSITVKTNLFVFK 471
+ S+ S A GL I E+NGQN ++ S+ +IL + T ++IT+ F+F+
Sbjct: 218 ITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMP-AFIFE 276
Query: 472 ELLTRLS 478
++ R++
Sbjct: 277 HIIKRMA 283
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,861,159
Number of Sequences: 37866
Number of extensions: 1274086
Number of successful extensions: 5639
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 5162
Number of HSP's gapped (non-prelim): 500
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.