Guide to the Human Genome
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Search of human proteins with 19743846

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19743846 decorin isoform a preproprotein [Homo sapiens]
         (359 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19743846 decorin isoform a preproprotein [Homo sapiens]            723   0.0  
gi|4503271 decorin isoform a preproprotein [Homo sapiens]             723   0.0  
gi|4502403 biglycan preproprotein [Homo sapiens]                      397   e-111
gi|41350214 asporin [Homo sapiens]                                    369   e-102
gi|19743848 decorin isoform b precursor [Homo sapiens]                365   e-101
gi|19743850 decorin isoform c precursor [Homo sapiens]                291   6e-79
gi|19743852 decorin isoform d precursor [Homo sapiens]                240   2e-63
gi|19743854 decorin isoform e precursor [Homo sapiens]                152   4e-37
gi|41349454 proline arginine-rich end leucine-rich repeat protei...   147   1e-35
gi|4506041 proline arginine-rich end leucine-rich repeat protein...   147   1e-35
gi|4505047 lumican precursor [Homo sapiens]                           137   1e-32
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]    134   2e-31
gi|45505137 podocan [Homo sapiens]                                    128   7e-30
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...   125   8e-29
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...   125   8e-29
gi|5901992 keratocan [Homo sapiens]                                   123   3e-28
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]                  122   4e-28
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]                  122   4e-28
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   121   1e-27
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...   121   1e-27
gi|71040111 fibromodulin precursor [Homo sapiens]                     120   2e-27
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   119   5e-27
gi|51317373 netrin-G1 ligand [Homo sapiens]                           117   2e-26
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           116   3e-26
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   113   3e-25
gi|4826876 osteomodulin [Homo sapiens]                                112   7e-25
gi|11321571 slit homolog 3 [Homo sapiens]                             109   3e-24
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         109   3e-24
gi|188528675 slit homolog 1 [Homo sapiens]                            109   4e-24
gi|4759146 slit homolog 2 [Homo sapiens]                              105   6e-23

>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score =  723 bits (1866), Expect = 0.0
 Identities = 359/359 (100%), Positives = 359/359 (100%)

Query: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
           MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
           HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV
Sbjct: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120

Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
           SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
Sbjct: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180

Query: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
           LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS
Sbjct: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240

Query: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
           LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH
Sbjct: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300

Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
           NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359


>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score =  723 bits (1866), Expect = 0.0
 Identities = 359/359 (100%), Positives = 359/359 (100%)

Query: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
           MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
           HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV
Sbjct: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120

Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180
           SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
Sbjct: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE 180

Query: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240
           LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS
Sbjct: 181 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS 240

Query: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300
           LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH
Sbjct: 241 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 300

Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
           NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score =  397 bits (1020), Expect = e-111
 Identities = 202/362 (55%), Positives = 257/362 (70%), Gaps = 10/362 (2%)

Query: 7   LLLLAQVSWAGPFQQRGLFDFMLED--------EASGIGPE-VPDDRDFEPSLGPVCPFR 57
           L+ L  +S A PF+QRG +DF L+D        EASG     V D     P+   +CPF 
Sbjct: 7   LVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFG 66

Query: 58  CQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
           C CHLRVVQCSDLGL  VPK++ PDTTLLDLQNN I+E++  DFK L++L+AL+LVNNKI
Sbjct: 67  CHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKI 126

Query: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMI 177
           SK+   AF+PL KL++LY+SKN L E+P  +P +L ELR H+N I KV K  F+GL  M 
Sbjct: 127 SKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMN 186

Query: 178 VIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVD 237
            IE+G NPL++SG E GAF G+ KL+Y+RI++  +T IP+ LP +L ELHLD NKI  ++
Sbjct: 187 CIEMGGNPLENSGFEPGAFDGL-KLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIE 245

Query: 238 AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
              L   + L +LGL  N I  ++NGSL+  P LRELHLDNNKL RVP GL + K +QVV
Sbjct: 246 LEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVV 305

Query: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGN 357
           YLH+NNI+ VG +DFCP G   K+A Y+G+SLF+NPV YWE+QP+TFRCV  R AIQ GN
Sbjct: 306 YLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGN 365

Query: 358 YK 359
           YK
Sbjct: 366 YK 367


>gi|41350214 asporin [Homo sapiens]
          Length = 380

 Score =  369 bits (947), Expect = e-102
 Identities = 191/380 (50%), Positives = 256/380 (67%), Gaps = 24/380 (6%)

Query: 1   MKATIILLLLAQVSWAGPF---QQRGLFDFMLEDEASGIGPEVPDDRD------------ 45
           MK  ++LL LA  S A PF       L + ML+D       +  DD D            
Sbjct: 1   MKEYVLLLFLALCS-AKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPT 59

Query: 46  -------FEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKD 98
                  F   L P+CPF CQC+ RVV CSDLGL  VP ++P DT +LDLQNNKI EIK+
Sbjct: 60  REPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKE 119

Query: 99  GDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAH 158
            DFK L +L+ LIL NNK++K+ P AF    KL RLYLS NQL E+P  +PK+L ELR H
Sbjct: 120 NDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIH 179

Query: 159 ENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQG 218
           EN++ K++K TF G+N + V+E+  NPL ++GIE GAF+G+  + +IRIA+  +TS+P+G
Sbjct: 180 ENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVT-VFHIRIAEAKLTSVPKG 238

Query: 219 LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDN 278
           LPP+L ELHLD NKIS V+    K    L +LGL  N I+ ++NGSLAN P +RE+HL+N
Sbjct: 239 LPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLEN 298

Query: 279 NKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWE 338
           NKL ++P GL E KY+Q+++LH+N+I+ VG +DFCP     KK+ YS +SLF+NPV+YWE
Sbjct: 299 NKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWE 358

Query: 339 IQPSTFRCVYVRSAIQLGNY 358
           +QP+TFRCV  R ++QLGN+
Sbjct: 359 MQPATFRCVLSRMSVQLGNF 378


>gi|19743848 decorin isoform b precursor [Homo sapiens]
          Length = 250

 Score =  365 bits (938), Expect = e-101
 Identities = 180/181 (99%), Positives = 181/181 (100%)

Query: 179 IELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA 238
           +ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA
Sbjct: 70  LELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDA 129

Query: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY 298
           ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY
Sbjct: 130 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVY 189

Query: 299 LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY 358
           LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY
Sbjct: 190 LHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNY 249

Query: 359 K 359
           K
Sbjct: 250 K 250



 Score =  184 bits (467), Expect = 1e-46
 Identities = 112/254 (44%), Positives = 139/254 (54%), Gaps = 51/254 (20%)

Query: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
           MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61  HLRVVQCSDL-------------------------------GLDKVPKDLPPDTTLLDLQ 89
           HLRVVQCSDL                                +  +P+ LPP  T L L 
Sbjct: 61  HLRVVQCSDLELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 120

Query: 90  NNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMP 149
            NKI+ +     K L NL  L L  N IS V  G+      L  L+L  N+L  +P  + 
Sbjct: 121 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLA 180

Query: 150 --KTLQELRAHENEITKV------------RKVTFNGLNQMIVIELGTNPLKSSGIENGA 195
             K +Q +  H N I+ V            +K +++G      + L +NP++   I+   
Sbjct: 181 EHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSG------VSLFSNPVQYWEIQPST 234

Query: 196 FQGMKKLSYIRIAD 209
           F+ +   S I++ +
Sbjct: 235 FRCVYVRSAIQLGN 248


>gi|19743850 decorin isoform c precursor [Homo sapiens]
          Length = 212

 Score =  291 bits (745), Expect = 6e-79
 Identities = 142/142 (100%), Positives = 142/142 (100%)

Query: 218 GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 277
           GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD
Sbjct: 71  GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 130

Query: 278 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW 337
           NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW
Sbjct: 131 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYW 190

Query: 338 EIQPSTFRCVYVRSAIQLGNYK 359
           EIQPSTFRCVYVRSAIQLGNYK
Sbjct: 191 EIQPSTFRCVYVRSAIQLGNYK 212



 Score =  191 bits (486), Expect = 7e-49
 Identities = 112/223 (50%), Positives = 136/223 (60%), Gaps = 27/223 (12%)

Query: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
           MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
           HLRVVQCSDLG       LPP  T L L  NKI+ +     K L NL  L L  N IS V
Sbjct: 61  HLRVVQCSDLG-------LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 113

Query: 121 SPGAFTPLVKLERLYLSKNQLKELPEKMP--KTLQELRAHENEITKV------------R 166
             G+      L  L+L  N+L  +P  +   K +Q +  H N I+ V            +
Sbjct: 114 DNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTK 173

Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIAD 209
           K +++G      + L +NP++   I+   F+ +   S I++ +
Sbjct: 174 KASYSG------VSLFSNPVQYWEIQPSTFRCVYVRSAIQLGN 210



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 148 MPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRI 207
           +P +L EL    N+I++V   +  GLN +  + L  N +  S ++NG+      L  + +
Sbjct: 72  LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHL 129

Query: 208 ADTNITSIPQGLPPS--LTELHLDGNKISRVDAA 239
            +  +T +P GL     +  ++L  N IS V ++
Sbjct: 130 DNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSS 163


>gi|19743852 decorin isoform d precursor [Homo sapiens]
          Length = 172

 Score =  240 bits (612), Expect = 2e-63
 Identities = 116/127 (91%), Positives = 117/127 (92%)

Query: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
           MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1   MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
           HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLH + L NN IS V
Sbjct: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVV 120

Query: 121 SPGAFTP 127
               F P
Sbjct: 121 GSSDFCP 127



 Score =  149 bits (375), Expect = 5e-36
 Identities = 73/92 (79%), Positives = 78/92 (84%), Gaps = 1/92 (1%)

Query: 269 PHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGV 327
           P    L L NNK+T +  G  ++ K + VVYLHNNNISVVGSSDFCPPGHNTKKASYSGV
Sbjct: 81  PDTTLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVVGSSDFCPPGHNTKKASYSGV 140

Query: 328 SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 359
           SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Sbjct: 141 SLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK 172


>gi|19743854 decorin isoform e precursor [Homo sapiens]
          Length = 75

 Score =  152 bits (384), Expect = 4e-37
 Identities = 71/71 (100%), Positives = 71/71 (100%)

Query: 1  MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60
          MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
Sbjct: 1  MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC 60

Query: 61 HLRVVQCSDLG 71
          HLRVVQCSDLG
Sbjct: 61 HLRVVQCSDLG 71


>gi|41349454 proline arginine-rich end leucine-rich repeat protein
           precursor [Homo sapiens]
          Length = 382

 Score =  147 bits (372), Expect = 1e-35
 Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 15/289 (5%)

Query: 32  EASGIGPEVPDDRDFEPSLGPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDL 88
           E + + P +P      PS+ P CP  C C       + C    L KVP  +PP    L L
Sbjct: 54  EPTDLPPPLPPG---PPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHYLYL 109

Query: 89  QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148
           QNN ITE+    F+N   L  + L NN+I K+       L  L  LY+ KNQL+E+P  +
Sbjct: 110 QNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSAL 169

Query: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
           P+ L++LR  +N I+++    F+ L  +++++L  N L     +   F G+K L  + +A
Sbjct: 170 PRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLA 229

Query: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG---SL 265
              +  +P  +P ++ +L+LD NKI  +     K   NLA + L++N ++  D G   + 
Sbjct: 230 HNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLT--DRGLPKNS 287

Query: 266 ANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
            N  +L  LHL +N+++ VP   A +  ++ +YL+NN+I  +  +  CP
Sbjct: 288 FNISNLLVLHLSHNRISSVP---AINNRLEHLYLNNNSIEKINGTQICP 333


>gi|4506041 proline arginine-rich end leucine-rich repeat protein
           precursor [Homo sapiens]
          Length = 382

 Score =  147 bits (372), Expect = 1e-35
 Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 15/289 (5%)

Query: 32  EASGIGPEVPDDRDFEPSLGPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDL 88
           E + + P +P      PS+ P CP  C C       + C    L KVP  +PP    L L
Sbjct: 54  EPTDLPPPLPPG---PPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPRIHYLYL 109

Query: 89  QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148
           QNN ITE+    F+N   L  + L NN+I K+       L  L  LY+ KNQL+E+P  +
Sbjct: 110 QNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSAL 169

Query: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
           P+ L++LR  +N I+++    F+ L  +++++L  N L     +   F G+K L  + +A
Sbjct: 170 PRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLA 229

Query: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG---SL 265
              +  +P  +P ++ +L+LD NKI  +     K   NLA + L++N ++  D G   + 
Sbjct: 230 HNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLT--DRGLPKNS 287

Query: 266 ANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
            N  +L  LHL +N+++ VP   A +  ++ +YL+NN+I  +  +  CP
Sbjct: 288 FNISNLLVLHLSHNRISSVP---AINNRLEHLYLNNNSIEKINGTQICP 333


>gi|4505047 lumican precursor [Homo sapiens]
          Length = 338

 Score =  137 bits (345), Expect = 1e-32
 Identities = 101/323 (31%), Positives = 159/323 (49%), Gaps = 17/323 (5%)

Query: 43  DRDFEPSL----GPVCPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITE 95
           D DF  S+     P C   C C   +   + C +L L  VP  +PP    L L+NN+I  
Sbjct: 22  DYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDH 80

Query: 96  IKDGDFKNLKNLHALILVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQ 153
           I +  F+N+ +L  LIL +N +  SK+    F+ L +L++L+++ N L E    +PK+L+
Sbjct: 81  IDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLE 140

Query: 154 ELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNIT 213
           +L+   N+ITK+   +F GL  +  I L  N LK   + + AF+G+K L Y+ ++   I 
Sbjct: 141 DLQLTHNKITKLG--SFEGLVNLTFIHLQHNRLKEDAV-SAAFKGLKSLEYLDLSFNQIA 197

Query: 214 SIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS-AVDNGSLANTPHLR 272
            +P GLP SL  L+LD NKIS +     K  N L  L LS N ++ +   G+  N   L 
Sbjct: 198 RLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLV 257

Query: 273 ELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSN 332
           EL L  NKL  +P     ++ ++  YL  N +       FC        +    + L  N
Sbjct: 258 ELDLSYNKLKNIP---TVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGN 314

Query: 333 PVQYWEIQPSTFRCVYVRSAIQL 355
            +    + P  + C+ V + + L
Sbjct: 315 RISETSLPPDMYECLRVANEVTL 337


>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
          Length = 699

 Score =  134 bits (336), Expect = 2e-31
 Identities = 83/251 (33%), Positives = 125/251 (49%), Gaps = 5/251 (1%)

Query: 55  PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVN 114
           P  C    R + C +  L ++P    P  T L+L  N I  I D  F  L NL  L L  
Sbjct: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376

Query: 115 NKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
           N I  S + P AF  L KL RL +  N L ++P ++P TL+EL+ +EN +  + + + + 
Sbjct: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436

Query: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
           LNQ++ +EL  N L  + +   AF+ +K L+Y+R+       IPQGLP S+ EL+L+ N+
Sbjct: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496

Query: 233 ISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAE 290
           I  +          +  + L +N I       LA  N  +L  + L  NKL  VP  L +
Sbjct: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPK 556

Query: 291 HKYIQVVYLHN 301
              + +V L N
Sbjct: 557 -SLLHLVLLGN 566



 Score =  117 bits (293), Expect = 2e-26
 Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 7/290 (2%)

Query: 72  LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLV 129
           L ++P  LP     L +  N +  I +    +L  L  L L  N +S+  V+P AF PL 
Sbjct: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464

Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
            L  L L KN+ + +P+ +P +++EL    N+I ++ ++ FN   ++ VI L  N ++ +
Sbjct: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524

Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLN-NLA 248
            I   A+   + L  I ++   +  +P  LP SL  L L GN+I R+       +   L 
Sbjct: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584

Query: 249 KLGLSFNSIS--AVDNGSLANTPH-LRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 305
            L LSFN ++   +D  S     H LREL LD+N L  +P G+ E K +  + L+NN I 
Sbjct: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644

Query: 306 VVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
            +   + C        ++   + L +N ++  EI   TF C+   S+I L
Sbjct: 645 NILPEEIC-NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score =  128 bits (322), Expect = 7e-30
 Identities = 95/328 (28%), Positives = 153/328 (46%), Gaps = 23/328 (7%)

Query: 26  DFMLEDEASGIGPEVPDDRDFEPSLGPV---CPFRCQCHLR-VVQCSDLGLDKVPKDLPP 81
           +F  E+    + PE       EP  GP    CP  C C    VV C  + L + P DLP 
Sbjct: 92  EFAEEEPVLVLSPE-------EPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPE 144

Query: 82  DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLVKLERLYLSKN 139
            T  L LQNN++ +I   +   L  L  L L NN+++   +   AF  L  L  LYL+ N
Sbjct: 145 HTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN 204

Query: 140 QLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGM 199
           +L   P  +P  L  +    N +TK+  +TF     +  + L  N L  +G+ +  F G 
Sbjct: 205 KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGS 264

Query: 200 KKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS- 258
             +  + ++   +  +P+ LPP+L +LHL  NK+ ++   +   L++L +L L  N ++ 
Sbjct: 265 SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324

Query: 259 -AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGH 317
             +DN +      L  L L +N L+RVP GL   + + +++L  N I  V ++   P   
Sbjct: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLP--RSLVLLHLEKNAIRSVDANVLTP--- 379

Query: 318 NTKKASYSGVSLFSNPVQYWEIQPSTFR 345
                S   + L SN ++   I P  F+
Sbjct: 380 ---IRSLEYLLLHSNQLREQGIHPLAFQ 404



 Score =  112 bits (279), Expect = 7e-25
 Identities = 79/265 (29%), Positives = 126/265 (47%), Gaps = 6/265 (2%)

Query: 52  PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           P   F    +L  +  ++  L   P+ LP     +D   N +T+I    F    NL ++ 
Sbjct: 186 PEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVY 245

Query: 112 LVNNKISKVS--PGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
           L NNK++        F     +E L LS N L+ +P+ +P  L +L    N++ K+    
Sbjct: 246 LHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGA 305

Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
           F+ L+ +  + L  N L   G++N  F  +  L Y+ ++  N++ +P GLP SL  LHL+
Sbjct: 306 FSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLE 365

Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGG 287
            N I  VDA  L  + +L  L L  N +       LA      L  +HL NN L RVP G
Sbjct: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425

Query: 288 LAEHKYIQVVYLHNNNISVVGSSDF 312
           L   + ++ + + +N I+ +G  DF
Sbjct: 426 LP--RRVRTLMILHNQITGIGREDF 448



 Score =  105 bits (262), Expect = 6e-23
 Identities = 74/243 (30%), Positives = 116/243 (47%), Gaps = 4/243 (1%)

Query: 56  FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
           F    ++ V+  S   L  VPK LPP    L L+NNK+ +I  G F  L +L  L L NN
Sbjct: 261 FNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN 320

Query: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
            ++   +    F  L  LE L LS N L  +P  +P++L  L   +N I  V       +
Sbjct: 321 YLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI 380

Query: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
             +  + L +N L+  GI   AFQG+K+L  + + +  +  +P GLP  +  L +  N+I
Sbjct: 381 RSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQI 440

Query: 234 SRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
           + +          L +L LS+N I++  V   +      LR L L  N+L  +P GL  +
Sbjct: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500

Query: 292 KYI 294
            ++
Sbjct: 501 VHV 503



 Score =  104 bits (259), Expect = 1e-22
 Identities = 75/288 (26%), Positives = 140/288 (48%), Gaps = 12/288 (4%)

Query: 62  LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK-- 119
           L  +  S   L +VP  LP    LL L+ N I  +       +++L  L+L +N++ +  
Sbjct: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397

Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
           + P AF  L +L  ++L  N L+ +P  +P+ ++ L    N+IT + +  F     +  +
Sbjct: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457

Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
            L  N + S  +   AF+ ++ L  + ++   + ++P GLP ++  L +  N+++ +   
Sbjct: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517

Query: 240 SLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
           +L G+  L +L L+ N + +   G  A  +  HL+ L +  N+LT +P GL E   ++ +
Sbjct: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES--LEYL 575

Query: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFR 345
           YL NN IS V ++ F          +  G+ L  N +    +  S FR
Sbjct: 576 YLQNNKISAVPANAF------DSTPNLKGIFLRFNKLAVGSVVDSAFR 617



 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 4/222 (1%)

Query: 62  LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--K 119
           L  V   +  L++VP  LP     L + +N+IT I   DF     L  L L  N+I+  +
Sbjct: 409 LHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ 468

Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
           V   AF  L  L  L LS N+L  LP  +P+ +  L+   NE+  + +    G+ Q+  +
Sbjct: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528

Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
            L +N L+S  +   A+  +  L  + IA   +T IP+GLP SL  L+L  NKIS V A 
Sbjct: 529 YLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPAN 588

Query: 240 SLKGLNNLAKLGLSFN--SISAVDNGSLANTPHLRELHLDNN 279
           +     NL  + L FN  ++ +V + +     HL+ L ++ N
Sbjct: 589 AFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 2/81 (2%)

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNK--IS 118
           HL+++  +   L ++P+ LP     L LQNNKI+ +    F +  NL  + L  NK  + 
Sbjct: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609

Query: 119 KVSPGAFTPLVKLERLYLSKN 139
            V   AF  L  L+ L +  N
Sbjct: 610 SVVDSAFRRLKHLQVLDIEGN 630


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  125 bits (313), Expect = 8e-29
 Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C+C    + C+D  L  +P  +P D T L LQNN+I     G   +LKNL      
Sbjct: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
                          +K+ER+YL  N L E P  +PK ++EL   EN I   R +T++ L
Sbjct: 83  ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124

Query: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
           +++  +E   L  N + +  IE GAF+    L  + ++  ++++IP GLP ++ EL LD 
Sbjct: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184

Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
           N+IS + + SL+GL +L +L L  N ++   + +    N  +L EL L  N LT  P  L
Sbjct: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244

Query: 289 AEHKYIQVVYLHNNNISVVGSSDF 312
                ++ +YL +N+I+ V  + F
Sbjct: 245 PGTN-LRKLYLQDNHINRVPPNAF 267



 Score = 37.0 bits (84), Expect = 0.027
 Identities = 19/41 (46%), Positives = 26/41 (63%)

Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE 146
           NL  L L +N I++V P AF+ L +L RL +S N L  LP+
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 72  LDKVPKDLP-PDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
           L   P +LP  +   L LQ+N I  +    F  L+ L+ L + NN +S +  G F  L  
Sbjct: 237 LTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296

Query: 131 LERLYLSKN 139
           + +L L  N
Sbjct: 297 ITQLILRNN 305


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score =  125 bits (313), Expect = 8e-29
 Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C+C    + C+D  L  +P  +P D T L LQNN+I     G   +LKNL      
Sbjct: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
                          +K+ER+YL  N L E P  +PK ++EL   EN I   R +T++ L
Sbjct: 83  ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124

Query: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
           +++  +E   L  N + +  IE GAF+    L  + ++  ++++IP GLP ++ EL LD 
Sbjct: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184

Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
           N+IS + + SL+GL +L +L L  N ++   + +    N  +L EL L  N LT  P  L
Sbjct: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244

Query: 289 AEHKYIQVVYLHNNNISVVGSSDF 312
                ++ +YL +N+I+ V  + F
Sbjct: 245 PGTN-LRKLYLQDNHINRVPPNAF 267



 Score = 37.0 bits (84), Expect = 0.027
 Identities = 19/41 (46%), Positives = 26/41 (63%)

Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE 146
           NL  L L +N I++V P AF+ L +L RL +S N L  LP+
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 72  LDKVPKDLP-PDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
           L   P +LP  +   L LQ+N I  +    F  L+ L+ L + NN +S +  G F  L  
Sbjct: 237 LTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296

Query: 131 LERLYLSKN 139
           + +L L  N
Sbjct: 297 ITQLILRNN 305


>gi|5901992 keratocan [Homo sapiens]
          Length = 352

 Score =  123 bits (308), Expect = 3e-28
 Identities = 80/269 (29%), Positives = 140/269 (52%), Gaps = 14/269 (5%)

Query: 54  CPFRCQC---HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
           CP  C C       + C + GL ++P  +P     L LQNN I  I +  F+N   L  +
Sbjct: 42  CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100

Query: 111 ILVNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV 168
            L  NKI+   +  GA + L KL  L+L  N+L+E+P  +P++L++L+   N+++++ + 
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160

Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHL 228
           TF+ L  + +++L  N L  +  +   F+G+K L  + +A   + ++P  LP +  +L L
Sbjct: 161 TFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFL 220

Query: 229 DGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA---NTPHLRELHLDNNKLTRVP 285
           D N I  +       +  +A L L+ N +S  D G  +   +   + +L L +N+LT+VP
Sbjct: 221 DNNSIEGIPENYFNVIPKVAFLRLNHNKLS--DEGLPSRGFDVSSILDLQLSHNQLTKVP 278

Query: 286 GGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
              A   ++Q ++L +N I  V  S  CP
Sbjct: 279 RISA---HLQHLHLDHNKIKSVNVSVICP 304


>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
          Length = 510

 Score =  122 bits (307), Expect = 4e-28
 Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)

Query: 54  CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
           CP RC C  +  V C  L L   P ++      L LQNN++ E+   +   L  L  L L
Sbjct: 44  CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 103

Query: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
            NN IS   +   AF  L +L+ L ++ N+L   P+ +P++L+      N++ ++  +TF
Sbjct: 104 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 163

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
                +  + L  N L ++G+   AF+G + ++ + +++  ++ +P  LPPSL  LHL  
Sbjct: 164 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 223

Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
           N IS+V   +L     L +L L  N +  S +D  + +    L  L L +N+LT VP GL
Sbjct: 224 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283

Query: 289 AEHKYIQVVYLHNNNISVV 307
              + + +++L  N I  V
Sbjct: 284 P--RTLAILHLGRNRIRQV 300



 Score =  117 bits (292), Expect = 2e-26
 Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)

Query: 72  LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
           L   P+ LP    + DL  N++ EI    F     L ++ L NN++S     P AF    
Sbjct: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193

Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
            +  L LS NQL  LP  +P +L+ L    N I+KV +   +   Q+  + L  N L  S
Sbjct: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253

Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
           G++   F  +  L Y+ ++   +T++P GLP +L  LHL  N+I +V+AA L G   L  
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313

Query: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
           L L  N +  S +  G+L     L  LHL  N L RVP  L   + ++ + L +N+++ +
Sbjct: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 371

Query: 308 GSSDF-CPPGHNTKKASYS 325
           G+ D    PG      +Y+
Sbjct: 372 GARDLVATPGLTELNLAYN 390



 Score =  102 bits (255), Expect = 4e-22
 Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)

Query: 52  PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           P   FR    +  +  S+  L  +P  LPP    L LQNN I+++  G       L  L 
Sbjct: 185 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 244

Query: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
           L +N++  S +    F+ L  LE L LS NQL  +P  +P+TL  L    N I +V    
Sbjct: 245 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 304

Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
            +G   +  + L  N L SSG+  GA + ++ L  + +    +  +P  LP  L  L L 
Sbjct: 305 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 364

Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
            N ++ + A  L     L +L L++N +++  V + +      LR L L  N+LTR+P G
Sbjct: 365 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 424

Query: 288 L 288
           L
Sbjct: 425 L 425



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)

Query: 62  LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
           L  +  S   L  VP  LP    +L L  N+I +++       + L  L+L +N++  S 
Sbjct: 266 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 325

Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
           +  GA  PL  L  L+L  N L  +P  +P+ L+ L    N +  +          +  +
Sbjct: 326 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 385

Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
            L  N L S+ + + AF+ ++ L  + +A   +T +P GLP  L  L L  N++  ++  
Sbjct: 386 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 445

Query: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
            L GL+ L +L L+ N +   D G
Sbjct: 446 PLAGLDQLRELSLAHNRLRVGDIG 469



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)

Query: 71  GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
           GLD+VP  LP     L L +N +  +   D      L  L L  N+++  +V   AF  L
Sbjct: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405

Query: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
             L  L L+ NQL  LP  +P  L+ L+   N++  +      GL+Q+  + L  N L+ 
Sbjct: 406 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465

Query: 189 SGIENGAFQGMKKL 202
             I  G +  ++ L
Sbjct: 466 GDIGPGTWHELQAL 479


>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
          Length = 512

 Score =  122 bits (307), Expect = 4e-28
 Identities = 78/259 (30%), Positives = 131/259 (50%), Gaps = 7/259 (2%)

Query: 54  CPFRCQC-HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALIL 112
           CP RC C  +  V C  L L   P ++      L LQNN++ E+   +   L  L  L L
Sbjct: 46  CPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNL 105

Query: 113 VNNKISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTF 170
            NN IS   +   AF  L +L+ L ++ N+L   P+ +P++L+      N++ ++  +TF
Sbjct: 106 HNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTF 165

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230
                +  + L  N L ++G+   AF+G + ++ + +++  ++ +P  LPPSL  LHL  
Sbjct: 166 GEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN 225

Query: 231 NKISRVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGL 288
           N IS+V   +L     L +L L  N +  S +D  + +    L  L L +N+LT VP GL
Sbjct: 226 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 285

Query: 289 AEHKYIQVVYLHNNNISVV 307
              + + +++L  N I  V
Sbjct: 286 P--RTLAILHLGRNRIRQV 302



 Score =  117 bits (292), Expect = 2e-26
 Identities = 82/259 (31%), Positives = 127/259 (49%), Gaps = 7/259 (2%)

Query: 72  LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129
           L   P+ LP    + DL  N++ EI    F     L ++ L NN++S     P AF    
Sbjct: 136 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 195

Query: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
            +  L LS NQL  LP  +P +L+ L    N I+KV +   +   Q+  + L  N L  S
Sbjct: 196 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 255

Query: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAK 249
           G++   F  +  L Y+ ++   +T++P GLP +L  LHL  N+I +V+AA L G   L  
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 315

Query: 250 LGLSFNSI--SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV 307
           L L  N +  S +  G+L     L  LHL  N L RVP  L   + ++ + L +N+++ +
Sbjct: 316 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAAL 373

Query: 308 GSSDF-CPPGHNTKKASYS 325
           G+ D    PG      +Y+
Sbjct: 374 GARDLVATPGLTELNLAYN 392



 Score =  102 bits (255), Expect = 4e-22
 Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)

Query: 52  PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           P   FR    +  +  S+  L  +P  LPP    L LQNN I+++  G       L  L 
Sbjct: 187 PPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELY 246

Query: 112 LVNNKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
           L +N++  S +    F+ L  LE L LS NQL  +P  +P+TL  L    N I +V    
Sbjct: 247 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 306

Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
            +G   +  + L  N L SSG+  GA + ++ L  + +    +  +P  LP  L  L L 
Sbjct: 307 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLP 366

Query: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGG 287
            N ++ + A  L     L +L L++N +++  V + +      LR L L  N+LTR+P G
Sbjct: 367 HNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMG 426

Query: 288 L 288
           L
Sbjct: 427 L 427



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 2/204 (0%)

Query: 62  LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKI--SK 119
           L  +  S   L  VP  LP    +L L  N+I +++       + L  L+L +N++  S 
Sbjct: 268 LEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSG 327

Query: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
           +  GA  PL  L  L+L  N L  +P  +P+ L+ L    N +  +          +  +
Sbjct: 328 LPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTEL 387

Query: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
            L  N L S+ + + AF+ ++ L  + +A   +T +P GLP  L  L L  N++  ++  
Sbjct: 388 NLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPE 447

Query: 240 SLKGLNNLAKLGLSFNSISAVDNG 263
            L GL+ L +L L+ N +   D G
Sbjct: 448 PLAGLDQLRELSLAHNRLRVGDIG 471



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%)

Query: 71  GLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPL 128
           GLD+VP  LP     L L +N +  +   D      L  L L  N+++  +V   AF  L
Sbjct: 348 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 407

Query: 129 VKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKS 188
             L  L L+ NQL  LP  +P  L+ L+   N++  +      GL+Q+  + L  N L+ 
Sbjct: 408 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 467

Query: 189 SGIENGAFQGMKKL 202
             I  G +  ++ L
Sbjct: 468 GDIGPGTWHELQAL 481


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  121 bits (303), Expect = 1e-27
 Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 11/269 (4%)

Query: 52  PVCPFRCQCHL-RVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
           P+C   C C   R V CS  GL  VP+ L   T  LD+  N IT++ +  FKN   L  L
Sbjct: 27  PLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL 86

Query: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRK 167
            L  N +S + P A + L +L+ L L  NQLK +P +  +    LQ LR   N IT V +
Sbjct: 87  QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146

Query: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGL---PPSLT 224
            +F GL Q+  + L  N L    +       +  L  + +A   I+SIP        SL 
Sbjct: 147 DSFEGLVQLRHLWLDDNSLTEVPVH--PLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204

Query: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRV 284
            LHL  NKI  +      GL+NL  L L++N++      ++   P L+EL   +N ++ +
Sbjct: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVI 263

Query: 285 PGGLAE-HKYIQVVYLHNNNISVVGSSDF 312
           P G  + +  ++ ++L++N +S VG+S F
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 82/287 (28%), Positives = 112/287 (39%), Gaps = 55/287 (19%)

Query: 52  PVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
           P   F     LR +   D  L +VP       P    L L  NKI+ I D  F NL +L 
Sbjct: 145 PEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204

Query: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE--KMPKTLQELRAHENEITKVR 166
            L L NNKI  +S   F  L  LE L L+ N L E P+  K   +L+EL  H N I+ + 
Sbjct: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264

Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQ-----------------------GMKKLS 203
              F+G   +  I L  NPL   G  N AF                        G   L 
Sbjct: 265 DGAFDGNPLLRTIHLYDNPLSFVG--NSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322

Query: 204 YIRIADTNITSIPQGLPP-------------------------SLTELHLDGNKISRVDA 238
            + +  T I+SIP  L                           +L E+ L  N+I ++  
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382

Query: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
            + +GL +L  L LS N I  + + + A    +  L +  N+LT  P
Sbjct: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 8/125 (6%)

Query: 61  HLRVVQCSDLGLDKVPKDLPPDTTLL---DLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
           HL  +  +   +  +P +L  +  +L   DL  N I ++    F     L  + L  N+I
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377

Query: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL---QELRAHENEITKVRKVTFNGLN 174
            ++  G F  L+ L  L LS+N + E+  +   TL     L    NE+T       NGLN
Sbjct: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437

Query: 175 QMIVI 179
           Q+ ++
Sbjct: 438 QLKLV 442


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score =  121 bits (303), Expect = 1e-27
 Identities = 78/254 (30%), Positives = 128/254 (50%), Gaps = 26/254 (10%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C+C    + C+D GL  +P D+P D T L LQNN+I     G  ++LK        
Sbjct: 54  CPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNA--GIPQDLKTK------ 105

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
                          V ++ +YL +N L E P  +P++L+EL   +N +  + + +   +
Sbjct: 106 ---------------VNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARI 150

Query: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
             +  + L  N + +  IE  AF   K+L  + ++  +++SIP GLP +L EL LD N+I
Sbjct: 151 PLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRI 210

Query: 234 SRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
           S +   + KGLN+L +L L  N ++   + + + +   +L EL L  N L   P  L   
Sbjct: 211 STIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPS- 269

Query: 292 KYIQVVYLHNNNIS 305
            ++Q +YL +N IS
Sbjct: 270 AHLQKLYLQDNAIS 283



 Score = 30.4 bits (67), Expect = 2.6
 Identities = 18/54 (33%), Positives = 26/54 (48%)

Query: 86  LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKN 139
           L LQ+N I+ I       ++ L  L L NN ++ +  G F  L  L +L L  N
Sbjct: 275 LYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 328


>gi|71040111 fibromodulin precursor [Homo sapiens]
          Length = 376

 Score =  120 bits (301), Expect = 2e-27
 Identities = 85/284 (29%), Positives = 140/284 (49%), Gaps = 25/284 (8%)

Query: 38  PEVPDDRDFEPSLGPVCPFRCQCHLR---VVQCSDLGLDKVPKDLPPDTTLLDLQNNKIT 94
           P  PD RD        CP  C C       + C +  L  +P  +P     +  QNN+IT
Sbjct: 68  PSPPDPRD--------CPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQIT 118

Query: 95  EIKDGDFKNLKNLHALILVNNKIS--KVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL 152
            I++G F N   L  + L  N+I+  KV    F+ L  LERLYL  N L  +P  +P++L
Sbjct: 119 SIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSL 178

Query: 153 QELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 212
           +EL    N+I++V      GL  +  + L  N ++  G    + +G++ L  + ++  ++
Sbjct: 179 RELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHL 235

Query: 213 TSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANT---P 269
             +P GLP +L +L+++ N +  V  +  +G   L  + LS NS++  +NG  +NT    
Sbjct: 236 RKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLT--NNGLASNTFNSS 293

Query: 270 HLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFC 313
            L EL L  N+L ++P     +  ++ +YL  N I+    S FC
Sbjct: 294 SLLELDLSYNQLQKIP---PVNTNLENLYLQGNRINEFSISSFC 334


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  119 bits (297), Expect = 5e-27
 Identities = 92/280 (32%), Positives = 137/280 (48%), Gaps = 19/280 (6%)

Query: 47  EPSLGPV-CPFRCQCH----LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDF 101
           +P  GP  CP  C C     +    CS+LGL  VP DL P T  LDL  N +TE++ G F
Sbjct: 27  QPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLF 86

Query: 102 KNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE----KMPKTLQELRA 157
            +L+ L  L L  N +S +   AF+ L  L+ L L  NQL  +P     ++P +LQ LR 
Sbjct: 87  HHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELP-SLQSLRL 145

Query: 158 HENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP- 216
             N I+ V + +F GL+ +  + L  N L    +   A   +  L  + +A   I+ IP 
Sbjct: 146 DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR--ALNNLPALQAMTLALNRISHIPD 203

Query: 217 ---QGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRE 273
              Q L  SL  LHL  N+I  +   S +GL+NL  L L++N +      ++     L+E
Sbjct: 204 YAFQNL-TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQE 261

Query: 274 LHLDNNKLTRVP-GGLAEHKYIQVVYLHNNNISVVGSSDF 312
           L   NN +  +P      +  +Q ++ ++N I  VG S F
Sbjct: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 301



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 81/305 (26%), Positives = 129/305 (42%), Gaps = 38/305 (12%)

Query: 49  SLGPVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLK 105
           SL P   F     LR +   D  L ++P    +  P    + L  N+I+ I D  F+NL 
Sbjct: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210

Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKT--LQELRAHENEIT 163
           +L  L L NN+I  +   +F  L  LE L L+ N+L+E P  +     LQEL  H N I 
Sbjct: 211 SLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIK 270

Query: 164 KVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSL 223
            + +  F G   +  I    NP++        F G     Y+               P L
Sbjct: 271 AIPEKAFMGNPLLQTIHFYDNPIQ--------FVGRSAFQYL---------------PKL 307

Query: 224 TELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTR 283
             L L+G  +   +   LKG  +L  L L+   I  + +G     P LR L L +N++  
Sbjct: 308 HTLSLNG-AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE 366

Query: 284 VPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPST 343
           +P  L   + ++ + L +N I  +G+  F      ++ +S   + L  N ++   I P  
Sbjct: 367 LP-SLHRCQKLEEIGLQHNRIWEIGADTF------SQLSSLQALDLSWNAIR--SIHPEA 417

Query: 344 FRCVY 348
           F  ++
Sbjct: 418 FSTLH 422



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 1/85 (1%)

Query: 62  LRVVQCSDLGLDKVPK-DLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV 120
           LRV++ S   ++++P          + LQ+N+I EI    F  L +L AL L  N I  +
Sbjct: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413

Query: 121 SPGAFTPLVKLERLYLSKNQLKELP 145
            P AF+ L  L +L L+ NQL  LP
Sbjct: 414 HPEAFSTLHSLVKLDLTDNQLTTLP 438


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  117 bits (292), Expect = 2e-26
 Identities = 83/256 (32%), Positives = 125/256 (48%), Gaps = 8/256 (3%)

Query: 54  CPFRCQC--HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           CP  C C      V C    L +VP  +  +T LL+L  N+I  IK   FK+L++L  L 
Sbjct: 47  CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106

Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE---KMPKTLQELRAHENEITKVRKV 168
           L  N I  +  GAF  L  L  L L  N+L  +P         L+EL    N I  +   
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166

Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP-PSLTELH 227
            FN +  +  ++LG    + S I  GAF+G+  L Y+ +A  N+  IP   P   L EL 
Sbjct: 167 AFNRIPSLRRLDLG-ELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELD 225

Query: 228 LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGG 287
           L GN +S +   S +GL +L KL +  + I  ++  +  N   L E++L +N LT +P  
Sbjct: 226 LSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHD 285

Query: 288 L-AEHKYIQVVYLHNN 302
           L     +++ ++LH+N
Sbjct: 286 LFTPLHHLERIHLHHN 301



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 7/210 (3%)

Query: 107 LHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVR 166
           L  L++     ++  P   +   +  ++   +  L+E+P+ +    + L  HEN+I  ++
Sbjct: 33  LQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92

Query: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQG---LPPSL 223
             +F  L  + +++L  N +++  IE GAF G+  L+ + + D  +T+IP G       L
Sbjct: 93  VNSFKHLRHLEILQLSRNHIRT--IEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKL 150

Query: 224 TELHLDGNKISRVDAASLKGLNNLAKLGL-SFNSISAVDNGSLANTPHLRELHLDNNKLT 282
            EL L  N I  + + +   + +L +L L     +S +  G+     +LR L+L    L 
Sbjct: 151 KELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLR 210

Query: 283 RVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
            +P  L     +  + L  N++S +    F
Sbjct: 211 EIP-NLTPLIKLDELDLSGNHLSAIRPGSF 239


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  116 bits (291), Expect = 3e-26
 Identities = 82/262 (31%), Positives = 127/262 (48%), Gaps = 9/262 (3%)

Query: 49  SLGPV-CPFRCQC--HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLK 105
           S GP  CP  C C      V C+  GL +VP+ +P +T  L+L  N I  I+   F++L 
Sbjct: 40  SAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLH 99

Query: 106 NLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE---KMPKTLQELRAHENEI 162
           +L  L L  N I ++  GAF  L  L  L L  N L  +P    +    L+EL    N I
Sbjct: 100 HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159

Query: 163 TKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP-P 221
             +    FN +  ++ ++LG    K   I  GAF+G+  L Y+ +   NI  +P   P  
Sbjct: 160 ESIPSYAFNRVPSLMRLDLG-ELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV 218

Query: 222 SLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 281
            L EL + GN    +   S  GL++L KL +  + +S ++  +      L EL+L +N L
Sbjct: 219 GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNL 278

Query: 282 TRVPGGL-AEHKYIQVVYLHNN 302
           + +P  L    +Y+  ++LH+N
Sbjct: 279 SSLPHDLFTPLRYLVELHLHHN 300


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  113 bits (282), Expect = 3e-25
 Identities = 82/271 (30%), Positives = 132/271 (48%), Gaps = 15/271 (5%)

Query: 54  CPFRCQCH-----LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
           CP  C C      L  V CSDLGL ++P +L   T+ LDL  N I+++      +L+ L 
Sbjct: 34  CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93

Query: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKV 165
            L L  N ++ +  GAFT L  L+ L L  NQL+ +P +     ++LQ LR   N I+ V
Sbjct: 94  ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153

Query: 166 RKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQ---GLPPS 222
               F+GL+ +  + L  N L    ++  AF+ +  L  + +A   I  IP    G   S
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQ--AFRSLSALQAMTLALNKIHHIPDYAFGNLSS 211

Query: 223 LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT 282
           L  LHL  N+I  +      GL++L  L L++N++      ++    +L+EL   +N + 
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIR 270

Query: 283 RVP-GGLAEHKYIQVVYLHNNNISVVGSSDF 312
            +P      +  +  ++ ++N I  VG S F
Sbjct: 271 SIPEKAFVGNPSLITIHFYDNPIQFVGRSAF 301



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 68/259 (26%), Positives = 92/259 (35%), Gaps = 72/259 (27%)

Query: 86  LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELP 145
           + L  NKI  I D  F NL +L  L L NN+I  +    F  L  LE L L+ N L E P
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250

Query: 146 EKMP--KTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIE----------- 192
             +     L+EL  H N I  + +  F G   +I I    NP++  G             
Sbjct: 251 TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTL 310

Query: 193 --NGAFQ--------GMKKLSYIRIADTNITSIPQ--------------------GLPP- 221
             NGA Q        G   L  + +    I+S+PQ                     LP  
Sbjct: 311 TLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSF 370

Query: 222 ----------------------------SLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253
                                       SL  L+L  NKI+ +   +   L +L KL LS
Sbjct: 371 SVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLS 430

Query: 254 FNSISAVDNGSLANTPHLR 272
            N +S+     L    HL+
Sbjct: 431 SNLLSSFPITGLHGLTHLK 449


>gi|4826876 osteomodulin [Homo sapiens]
          Length = 421

 Score =  112 bits (279), Expect = 7e-25
 Identities = 83/269 (30%), Positives = 132/269 (49%), Gaps = 16/269 (5%)

Query: 54  CPFRCQCHLRV---VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
           C   C C       + C +  L  +P ++P     L LQ N+I  +    F N  +L  +
Sbjct: 62  CVSECFCPTNFPSSMYCDNRKLKTIP-NIPMHIQQLYLQFNEIEAVTANSFINATHLKEI 120

Query: 111 ILVNNKIS--KVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKV 168
            L +NKI   K+  G F  L  L +L+L  N L+E P  +PK+L+ L    NEI+K++  
Sbjct: 121 NLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTN 180

Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHL 228
             +GL  + +++L  N L  S +++  F  M+KL  + +    + S+P GLP SL  L L
Sbjct: 181 AMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSL 240

Query: 229 DGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTR---VP 285
           + N IS +       L  L  L +S N +  +   ++ N P++ EL + +NKL +   +P
Sbjct: 241 ENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPY-NIFNLPNIVELSVGHNKLKQAFYIP 299

Query: 286 GGLAEHKYIQVVYLHNNNISVVGSSDFCP 314
             L EH     +YL NN I  +  +  CP
Sbjct: 300 RNL-EH-----LYLQNNEIEKMNLTVMCP 322


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  109 bits (273), Expect = 3e-24
 Identities = 65/166 (39%), Positives = 94/166 (56%), Gaps = 7/166 (4%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP +C C    V C  LGL  VP+ +P +   LDL  N IT I   DF  LKNL  L L 
Sbjct: 34  CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM----PKTLQELRAHENEITKVRKVT 169
           +N++S +  GAF  L +LERL L+KN+L+ LPE +    PK L  L   EN+I  + +  
Sbjct: 94  DNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPK-LTRLDLSENQIQGIPRKA 152

Query: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSI 215
           F G+  +  ++L  N +  S IE+GAF+ ++ L  + + + NI+ I
Sbjct: 153 FRGITDVKNLQLDNNHI--SCIEDGAFRALRDLEILTLNNNNISRI 196



 Score =  108 bits (269), Expect = 1e-23
 Identities = 99/366 (27%), Positives = 160/366 (43%), Gaps = 94/366 (25%)

Query: 53  VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALI 111
           VCP +C+C   +V CS+  L ++P  LP   T L L +N+++ ++  G FK L NL  + 
Sbjct: 504 VCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKIN 563

Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA-------------- 157
           L NNKI +V  GAF     ++ L L+ NQL+ +  ++ + L  L+               
Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623

Query: 158 -------------HENEITKVRKVTFNGLNQMIVIELGTNP------------------- 185
                        ++N IT +    F  L  +  I L +NP                   
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRI 683

Query: 186 ------------LKSSGIENGAFQ-----GMKKLS----------------YIRIADTNI 212
                       LK   I++ A Q     G ++ S                 +R ++  +
Sbjct: 684 VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGL 743

Query: 213 TSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLR 272
            ++P+G+P  +TEL+L+GN ++ V    L  L +L  + LS NSIS + N + +N  HL 
Sbjct: 744 RALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLS 802

Query: 273 ELHLDNNKLTRVP----GGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVS 328
            L L  N+L  +P     GL   + ++V+ LH N+IS V      P G      S S ++
Sbjct: 803 TLILSYNRLRCIPVHAFNGL---RSLRVLTLHGNDISSV------PEGSFNDLTSLSHLA 853

Query: 329 LFSNPV 334
           L +NP+
Sbjct: 854 LGTNPL 859



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 51/140 (36%), Positives = 78/140 (55%), Gaps = 4/140 (2%)

Query: 50  LGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHA 109
           L P CP +C C   VV+CS+ GL  +P+ +P D T L L+ N +T +   +   L++L  
Sbjct: 721 LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTL 779

Query: 110 LILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA---HENEITKVR 166
           + L NN IS ++   F+ +  L  L LS N+L+ +P      L+ LR    H N+I+ V 
Sbjct: 780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVP 839

Query: 167 KVTFNGLNQMIVIELGTNPL 186
           + +FN L  +  + LGTNPL
Sbjct: 840 EGSFNDLTSLSHLALGTNPL 859



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 51/168 (30%), Positives = 89/168 (52%), Gaps = 6/168 (3%)

Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
           L+ +P  +P+  + L    N IT++ K+ F GL  + V+ L  N +  S IE GAFQ +K
Sbjct: 52  LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV--SVIERGAFQDLK 109

Query: 201 KLSYIRIADTNITSIPQGL---PPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
           +L  +R+    +  +P+ L    P LT L L  N+I  +   + +G+ ++  L L  N I
Sbjct: 110 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 169

Query: 258 SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 304
           S +++G+      L  L L+NN ++R+      H   I+ + LH+N++
Sbjct: 170 SCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 71/294 (24%), Positives = 126/294 (42%), Gaps = 30/294 (10%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C C   +V C   GL ++P +LP     + L+ N I  I  G F   K L  + + 
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
            N+IS ++P AF  L  L  L L  N++ E+ + +     +LQ L  + N+I  +R  TF
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA------DTNITSIPQGLPPSLT 224
             L  + ++ L  N L++  I  G F  ++ +  + +A      D ++  +   L  +  
Sbjct: 400 QDLQNLNLLSLYDNKLQT--ISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN-- 455

Query: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLREL---------- 274
            +   G + S     + K ++ +      F    + D  S  ++    +L          
Sbjct: 456 PIETSGARCSSPRRLANKRISQIK--SKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEG 513

Query: 275 ---HLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYS 325
                 N KL R+P  L E  Y+  + L++N +SV+ ++       N +K + S
Sbjct: 514 TIVDCSNQKLVRIPSHLPE--YVTDLRLNDNEVSVLEATGIFKKLPNLRKINLS 565



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 52/263 (19%)

Query: 55  PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLD------LQNNKITEIKDGDFKNLKNLH 108
           PF C CHL+        L    +D P +T+         L N +I++IK   F+   +  
Sbjct: 438 PFVCDCHLK-------WLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGS-- 488

Query: 109 ALILVNNKISKVSPGAFTPLVKLER-------LYLSKNQLKELPEKMPKTLQELRAHENE 161
                 +  S+ S   F  LV  E+       +  S  +L  +P  +P+ + +LR ++NE
Sbjct: 489 -----EDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNE 543

Query: 162 ITKVRKV-TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLP 220
           ++ +     F  L  +  I L  N +K   +  GAF G                      
Sbjct: 544 VSVLEATGIFKKLPNLRKINLSNNKIKE--VREGAFDGAA-------------------- 581

Query: 221 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNK 280
            S+ EL L GN++  V     +GL+ L  L L  N I  V N + A    +R L L +N+
Sbjct: 582 -SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNR 640

Query: 281 LTRV-PGGLAEHKYIQVVYLHNN 302
           +T + PG       +  + L +N
Sbjct: 641 ITTITPGAFTTLVSLSTINLLSN 663



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 60/242 (24%), Positives = 101/242 (41%), Gaps = 11/242 (4%)

Query: 82  DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQL 141
           D   L L NN I+ I+DG F+ L++L  L L NN IS++   +F  + K+  L L  N L
Sbjct: 158 DVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217

Query: 142 --KELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELG-TNPLKSSGIENGAFQG 198
                   +   L++ R        +  V   G N   V +     P   S   +     
Sbjct: 218 YCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANS 277

Query: 199 MKKLSYIRIADTNITSIPQGL---PPSLTE----LHLDGNKISRVDAASLKGLNNLAKLG 251
           +   S    ++  +    +GL   P +L E    + L+ N I  + A +      L ++ 
Sbjct: 278 ISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRID 337

Query: 252 LSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLHNNNISVVGSS 310
           +S N IS +   +      L  L L  NK+T +  GL +    +Q++ L+ N I+ +  +
Sbjct: 338 ISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVN 397

Query: 311 DF 312
            F
Sbjct: 398 TF 399


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  109 bits (273), Expect = 3e-24
 Identities = 78/256 (30%), Positives = 122/256 (47%), Gaps = 9/256 (3%)

Query: 54  CPFRCQCHLRV--VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           CP  C C  +   V C+   L +VP  +P +T  L+LQ N I  I+   FK+L++L  L 
Sbjct: 57  CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116

Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELR---AHENEITKVRKV 168
           L  N + K+  GAF  L  L  L L  N+L  +P +  + L +LR      N I  +   
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176

Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQ-GLPPSLTELH 227
            FN +  +  ++LG    +   I   AF+G+  L Y+ +   N+  IP       L EL 
Sbjct: 177 AFNRVPSLRRLDLG-ELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELE 235

Query: 228 LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGG 287
           L GN++  +   S +GL +L KL L    ++ ++  +  +   L EL+L +N L  +P  
Sbjct: 236 LSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHD 295

Query: 288 LAE--HKYIQVVYLHN 301
           L    H+  +V   HN
Sbjct: 296 LFTPLHRLERVHLNHN 311



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 9/95 (9%)

Query: 100 DFKNLKNLHALI------LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PK 150
           + K++ NL AL+      L  N++  + PG+F  L  L +L+L   Q+  +        K
Sbjct: 218 NLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLK 277

Query: 151 TLQELRAHENEITKVRKVTFNGLNQMIVIELGTNP 185
           +L+EL    N +  +    F  L+++  + L  NP
Sbjct: 278 SLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNP 312


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  109 bits (272), Expect = 4e-24
 Identities = 63/166 (37%), Positives = 89/166 (53%), Gaps = 5/166 (3%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C C    V C   GL  +PK++P +T  L+L  N IT I   DF  LK L  L L+
Sbjct: 34  CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLM 93

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
            N+I  V  GAF  + +LERL L++NQL  LPE +    + L  L   EN I  + +  F
Sbjct: 94  ENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAF 153

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP 216
            G   +  ++L  N +  S IE GAF+ ++ L  + + + NIT+IP
Sbjct: 154 RGATDLKNLQLDKNQI--SCIEEGAFRALRGLEVLTLNNNNITTIP 197



 Score =  109 bits (272), Expect = 4e-24
 Identities = 84/295 (28%), Positives = 133/295 (45%), Gaps = 37/295 (12%)

Query: 53  VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALI 111
           VCP +C+C   VV+CS L L K+P+ +P  T  L L NN+I+ ++  G FK L +L  + 
Sbjct: 512 VCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571

Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRA---HENEITKVRKV 168
           L NNK+S++  GAF     +  L+L+ NQL+ +   M + L  LR      N I+ +   
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631

Query: 169 TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTN----------------- 211
           +F GL  + ++ L  N + +  +  GAF  ++ LS + +                     
Sbjct: 632 SFTGLRNVRLLSLYDNQITT--VSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKR 689

Query: 212 --ITSIPQGLPPS-LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANT 268
             +T  P+   P  L ++ L             +               + +D     + 
Sbjct: 690 KIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN 749

Query: 269 PHLR-----------ELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
            HLR           EL+LD N+ T VPG L+  KY+Q+V L NN IS + +S F
Sbjct: 750 KHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSF 804



 Score =  103 bits (257), Expect = 2e-22
 Identities = 96/395 (24%), Positives = 159/395 (40%), Gaps = 101/395 (25%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTT------------------------LLDLQ 89
           CP  C C   +V C   GL  +P +LP   T                         +DL 
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341

Query: 90  NNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMP 149
           NN+I EI    F+ L++L++L+L  NKI+ +  G F  L  L+ L L+ N++  +     
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401

Query: 150 KTLQELRA---HENEITKVRKVTFNGLNQMIVIELG------------------TNPLKS 188
           + LQ L     ++N+I  + K TF  L  +  + L                   TNP+++
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461

Query: 189 SG----------------IENGAFQGMKKLSY---------------------------- 204
           SG                I++  F+   K  Y                            
Sbjct: 462 SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEA 521

Query: 205 --IRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASL-KGLNNLAKLGLSFNSISAVD 261
             +  +   +T IP+ +P S  EL L+ N+IS ++A  + K L +L K+ LS N +S ++
Sbjct: 522 NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIE 581

Query: 262 NGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDFCPPGHNTK 320
           +G+      + ELHL  N+L  +  G+      ++ + L NN IS + +  F      T 
Sbjct: 582 DGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF------TG 635

Query: 321 KASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
             +   +SL+ N  Q   + P  F  +   S + L
Sbjct: 636 LRNVRLLSLYDN--QITTVSPGAFDTLQSLSTLNL 668



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 4/138 (2%)

Query: 52  PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
           P CP  C C   VV+CS+  L  +PK +P + T L L  N+ T +  G     K L  + 
Sbjct: 732 PQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVD 790

Query: 112 LVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELR---AHENEITKVRKV 168
           L NNKIS +S  +FT + +L  L LS N L+ +P    + L+ LR    H N+I+ +++ 
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850

Query: 169 TFNGLNQMIVIELGTNPL 186
            F  +  +  + +G NPL
Sbjct: 851 IFADVTSLSHLAIGANPL 868



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 24/173 (13%)

Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
           L+ +P+ +P+  + L  + N IT++ K  F GL Q+ V++L  N +    +E GAF  MK
Sbjct: 52  LQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI--GAVERGAFDDMK 109

Query: 201 KLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 260
           +L  +R+    +  +P        EL    N+              L++L LS N+I A+
Sbjct: 110 ELERLRLNRNQLHMLP--------ELLFQNNQA-------------LSRLDLSENAIQAI 148

Query: 261 DNGSLANTPHLRELHLDNNKLTRV-PGGLAEHKYIQVVYLHNNNISVVGSSDF 312
              +      L+ L LD N+++ +  G     + ++V+ L+NNNI+ +  S F
Sbjct: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF 201



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 75/291 (25%), Positives = 118/291 (40%), Gaps = 51/291 (17%)

Query: 86  LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELP 145
           LDL  N I  I    F+   +L  L L  N+IS +  GAF  L  LE L L+ N +  +P
Sbjct: 138 LDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIP 197

Query: 146 ----EKMPKTLQELRAHENEI------------TKVR-----------KVTFNGLNQMIV 178
                 MPK L+  R H N +             + R             +  GLN   V
Sbjct: 198 VSSFNHMPK-LRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLN---V 253

Query: 179 IELGTNPLKSSG-----------IENGAFQGMKKLS--YIRIADTNITSIPQGLPPSLTE 225
            E+  +    SG           + +G+   M   S   +      +T+IP  LP ++TE
Sbjct: 254 AEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313

Query: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
           + L+ N I  +   +      L ++ LS N I+ +   +      L  L L  NK+T +P
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373

Query: 286 GGLAEHKY-IQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQ 335
            G+    Y +Q++ L+ N I+ +    F          + S +SL+ N +Q
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAF------QDLQNLSLLSLYDNKIQ 418



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 26/76 (34%), Positives = 40/76 (52%)

Query: 210 TNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 269
           T + +IP+ +P +   L L+GN I+R+      GL  L  L L  N I AV+ G+  +  
Sbjct: 50  TGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMK 109

Query: 270 HLRELHLDNNKLTRVP 285
            L  L L+ N+L  +P
Sbjct: 110 ELERLRLNRNQLHMLP 125


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  105 bits (262), Expect = 6e-23
 Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 95/383 (24%)

Query: 40  VPDDRDFEPSLGP------VCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKI 93
           +P   D+   L         CP +C+C    V CS+  L+K+P+ +P  T  L L NN+ 
Sbjct: 486 IPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEF 545

Query: 94  TEIK-DGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL 152
           T ++  G FK L  L  +   NNKI+ +  GAF     +  + L+ N+L+ +  KM K L
Sbjct: 546 TVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGL 605

Query: 153 QELRA---------------------------HENEITKVRKVTFNGLNQMIVIELGTNP 185
           + L+                            ++N+IT V    F+ L+ +  + L  NP
Sbjct: 606 ESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANP 665

Query: 186 -------------------------------LKSSGIENGAFQGM-----------KKLS 203
                                          LK   I++ A Q               LS
Sbjct: 666 FNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLS 725

Query: 204 -----------YIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGL 252
                       +R ++  +  +P+G+P  +TEL+LDGN+ + V    L    +L  + L
Sbjct: 726 RCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDL 784

Query: 253 SFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSD 311
           S N IS + N S +N   L  L L  N+L  +P    +  K ++++ LH N+ISVV    
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV---- 840

Query: 312 FCPPGHNTKKASYSGVSLFSNPV 334
             P G     ++ S +++ +NP+
Sbjct: 841 --PEGAFNDLSALSHLAIGANPL 861



 Score =  104 bits (260), Expect = 1e-22
 Identities = 61/165 (36%), Positives = 90/165 (54%), Gaps = 5/165 (3%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP +C C    V C  L L  VP+++P +T  LDL  N IT I   DF  L++L  L L+
Sbjct: 28  CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLM 87

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRKVTF 170
            NKIS +  GAF  L +LERL L++N L+  PE +      L  L   EN+I  + +  F
Sbjct: 88  ENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAF 147

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSI 215
            G   +  ++L  N +  S IE+GAF+ ++ L  + + + NIT +
Sbjct: 148 RGAVDIKNLQLDYNQI--SCIEDGAFRALRDLEVLTLNNNNITRL 190



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 51/168 (30%), Positives = 87/168 (51%), Gaps = 6/168 (3%)

Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
           L+ +P  +P+  + L  + N IT++ K  F GL  + V++L  N  K S IE GAFQ +K
Sbjct: 46  LRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMEN--KISTIERGAFQDLK 103

Query: 201 KLSYIRIADTNITSIPQGL---PPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 257
           +L  +R+   ++   P+ L      L  L L  N+I  +   + +G  ++  L L +N I
Sbjct: 104 ELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQI 163

Query: 258 SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 304
           S +++G+      L  L L+NN +TR+      H   ++   LH+NN+
Sbjct: 164 SCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 5/158 (3%)

Query: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113
           CP  C C   +V C   GL ++P +LP   T + L+ N I  I  G F   K L  + L 
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332

Query: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRKVTF 170
           NN+IS+++P AF  L  L  L L  N++ ELP+ + +   +LQ L  + N+I  +R   F
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392

Query: 171 NGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208
             L+ + ++ L  N L++  I  G F  ++ +  + +A
Sbjct: 393 QDLHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMHLA 428



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 68/295 (23%), Positives = 128/295 (43%), Gaps = 33/295 (11%)

Query: 85  LLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKN----- 139
           LL L  NKI  ++   F++L NL+ L L +NK+  ++ G F+PL  ++ ++L++N     
Sbjct: 376 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD 435

Query: 140 -QLKELPEKM---------PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
             LK L + +          +     R     I +++   F    +      GT   +S 
Sbjct: 436 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK 495

Query: 190 GIENGAFQGMKKLSYIRIADTNI-------TSIPQGLPPSLTELHLDGNKISRVDAASL- 241
            +    F  +      R   T +         IP+ +P    EL L+ N+ + ++A  + 
Sbjct: 496 -LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIF 554

Query: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLH 300
           K L  L K+  S N I+ ++ G+      + E+ L +N+L  V   + +  + ++ + L 
Sbjct: 555 KKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLR 614

Query: 301 NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
           +N I+ VG+  F         +S   +SL+ N  Q   + P  F  ++  S + L
Sbjct: 615 SNRITCVGNDSF------IGLSSVRLLSLYDN--QITTVAPGAFDTLHSLSTLNL 661



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 66/242 (27%), Positives = 101/242 (41%), Gaps = 33/242 (13%)

Query: 55  PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFK-NLKNLHALILV 113
           PF C CHL+ +    L  + +       T+   L N +I +IK   F+ + K  + +   
Sbjct: 431 PFICDCHLKWL-ADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT 489

Query: 114 NNKISKVSPGAFTPLVKLER-------LYLSKNQLKELPEKMPKTLQELRAHENEITKVR 166
            +  SK+S   F  L   E+       +  S  +L ++PE +P+   ELR + NE T + 
Sbjct: 490 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE 549

Query: 167 KV-TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE 225
               F  L Q+  I    N  K + IE GAF+G                        + E
Sbjct: 550 ATGIFKKLPQLRKINFSNN--KITDIEEGAFEGAS---------------------GVNE 586

Query: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
           + L  N++  V     KGL +L  L L  N I+ V N S      +R L L +N++T V 
Sbjct: 587 ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 646

Query: 286 GG 287
            G
Sbjct: 647 PG 648



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 26/242 (10%)

Query: 82  DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQL 141
           D   L L  N+I+ I+DG F+ L++L  L L NN I+++S  +F  + KL    L  N L
Sbjct: 152 DIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211

Query: 142 ---------KELPEKMPKT--------LQELRAHENEITKVRKVTFNGLNQMIVIELGTN 184
                     +   + P+            LR H     + R+   +G    +       
Sbjct: 212 YCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMA------ 265

Query: 185 PLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGL 244
              S  + +         + +      +T IP  LP ++TE+ L+ N I  +   +    
Sbjct: 266 --PSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPY 323

Query: 245 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLHNNN 303
             L ++ LS N IS +   +      L  L L  NK+T +P  L E  + +Q++ L+ N 
Sbjct: 324 KKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANK 383

Query: 304 IS 305
           I+
Sbjct: 384 IN 385



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 24/163 (14%)

Query: 141 LKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMK 200
           L E+P  +P+T+ E+R  +N I  +    F+   ++  I+L  N +  S +   AFQG++
Sbjct: 291 LTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI--SELAPDAFQGLR 348

Query: 201 KLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAV 260
                                SL  L L GNKI+ +  +  +GL +L  L L+ N I+ +
Sbjct: 349 ---------------------SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL 387

Query: 261 DNGSLANTPHLRELHLDNNKL-TRVPGGLAEHKYIQVVYLHNN 302
              +  +  +L  L L +NKL T   G  +  + IQ ++L  N
Sbjct: 388 RVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,226,895
Number of Sequences: 37866
Number of extensions: 644396
Number of successful extensions: 4370
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 1812
Number of HSP's gapped (non-prelim): 1123
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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