Search of human proteins with 189571674

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189571674 cadherin-like 23 isoform 1 precursor [Homo
sapiens]
         (3354 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]     6640   0.0  
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]           1061   0.0  
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]       967   0.0  
gi|16933557 dachsous 1 precursor [Homo sapiens]                       922   0.0  
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           899   0.0  
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            895   0.0  
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           869   0.0  
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                       738   0.0  
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   444   e-124
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...   413   e-114
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...   395   e-109
gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                      360   2e-98
gi|16933559 protocadherin LKC precursor [Homo sapiens]                323   2e-87
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi...   305   4e-82
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi...   301   9e-81
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...   290   1e-77
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...   290   1e-77
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi...   290   1e-77
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi...   290   1e-77
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi...   290   1e-77
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi...   290   1e-77
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi...   290   1e-77
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi...   290   1e-77
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi...   290   1e-77
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         285   4e-76
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        285   4e-76
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi...   285   5e-76
gi|16933565 protocadherin 21 precursor [Homo sapiens]                 281   8e-75
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        265   4e-70
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        265   4e-70

>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score = 6640 bits (17226), Expect = 0.0
 Identities = 3354/3354 (100%), Positives = 3354/3354 (100%)

Query: 1    MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
            MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1    MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60

Query: 61   DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
            DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61   DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120

Query: 121  QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
            QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121  QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180

Query: 181  DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
            DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181  DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240

Query: 241  YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
            YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241  YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300

Query: 301  RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
            RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301  RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360

Query: 361  AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
            AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361  AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420

Query: 421  YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
            YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421  YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540
            TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG
Sbjct: 481  TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540

Query: 541  EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600
            EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI
Sbjct: 541  EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
            VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE
Sbjct: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR 720
            VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR
Sbjct: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR 720

Query: 721  INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
            INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD
Sbjct: 721  INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780

Query: 781  APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML 840
            APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML
Sbjct: 781  APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML 840

Query: 841  DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
            DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL
Sbjct: 841  DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900

Query: 901  EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE 960
            EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE
Sbjct: 901  EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE 960

Query: 961  YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
            YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT
Sbjct: 961  YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020

Query: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080
            DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK
Sbjct: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080

Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140
            RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR
Sbjct: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140

Query: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
            ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED
Sbjct: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200

Query: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE 1260
            INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE
Sbjct: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE 1260

Query: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA 1320
            STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA
Sbjct: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA 1320

Query: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
            AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE
Sbjct: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380

Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
            KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT
Sbjct: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440

Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
            VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS
Sbjct: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500

Query: 1501 DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN 1560
            DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN
Sbjct: 1501 DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN 1560

Query: 1561 SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV 1620
            SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV
Sbjct: 1561 SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV 1620

Query: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680
            YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV
Sbjct: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680

Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
            NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN
Sbjct: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740

Query: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
            VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV
Sbjct: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800

Query: 1801 LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
            LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI
Sbjct: 1801 LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860

Query: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920
            SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP
Sbjct: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920

Query: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980
            EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV
Sbjct: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980

Query: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL 2040
            LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL
Sbjct: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL 2040

Query: 2041 LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL 2100
            LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL
Sbjct: 2041 LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL 2100

Query: 2101 NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
            NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV
Sbjct: 2101 NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160

Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT 2220
            TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT
Sbjct: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT 2220

Query: 2221 DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT 2280
            DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT
Sbjct: 2221 DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT 2280

Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 2340
            VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP
Sbjct: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 2340

Query: 2341 PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
            PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP
Sbjct: 2341 PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400

Query: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL 2460
            IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL
Sbjct: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL 2460

Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
            SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE
Sbjct: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520

Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT 2580
            NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT
Sbjct: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT 2580

Query: 2581 VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK 2640
            VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK
Sbjct: 2581 VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK 2640

Query: 2641 DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
            DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV
Sbjct: 2641 DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700

Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760
            PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760

Query: 2761 NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
            NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT
Sbjct: 2761 NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820

Query: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
            LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL
Sbjct: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880

Query: 2881 VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH 2940
            VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH
Sbjct: 2881 VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH 2940

Query: 2941 NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG 3000
            NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG
Sbjct: 2941 NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG 3000

Query: 3001 RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD 3060
            RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD
Sbjct: 3001 RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD 3060

Query: 3061 DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT 3120
            DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT
Sbjct: 3061 DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT 3120

Query: 3121 NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV 3180
            NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV
Sbjct: 3121 NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV 3180

Query: 3181 KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC 3240
            KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC
Sbjct: 3181 KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC 3240

Query: 3241 HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL 3300
            HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL
Sbjct: 3241 HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL 3300

Query: 3301 PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL 3354
            PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL
Sbjct: 3301 PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL 3354


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score = 1061 bits (2745), Expect = 0.0
 Identities = 880/2873 (30%), Positives = 1352/2873 (47%), Gaps = 195/2873 (6%)

Query: 73   EASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
            E+   FA+   TG ++    +DRE+     +   V         +V + V D+NDNAP F
Sbjct: 76   ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVF 135

Query: 133  HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ----PPSQFFAID-----SA 183
             +    V   E++  G  + +  ATD D+G+ G    S++      +  F +D     S 
Sbjct: 136  PDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSG 195

Query: 184  RGIVTVIRE---LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
             G    +     LD E T  YQL V   D+ + +    L  + + + D+ D  P+F +  
Sbjct: 196  EGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYL-QVNVTVQDINDNPPVFGSSH 254

Query: 241  YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
            Y   + E +  G++V  + A D D+G    I Y +    T   F +D  +G++T+   LD
Sbjct: 255  YQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLD 312

Query: 301  RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP-----EFNSSEYSV 355
             E       + LTV+      DR     T      I ++D+NDN P      F ++    
Sbjct: 313  FE---ARRQYSLTVQAM----DRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYA 365

Query: 356  AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
            ++ E AQVG  + L + V D D      ++    L GN   HF +  + V   +   I+V
Sbjct: 366  SVDENAQVGTVVAL-LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLS--LIKV 422

Query: 416  AIPLDYETVDRYDFDLFANE--------SVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
            A  LD E +  Y+  +  ++        +V      A + I + + ND+ P+FSQ +Y +
Sbjct: 423  ASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRV 482

Query: 468  SLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIML--IARLDY 523
            +L E    G+ V  + ATD D+G    + Y     +    F + + +GL+       LD 
Sbjct: 483  NLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDR 542

Query: 524  ELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTF-QKDAYVGALRENEPSVTQL 580
            EL  +  L I ARD G   + +  ++ + +LDVND  P F Q + Y  ++ EN P+ T+L
Sbjct: 543  ELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602

Query: 581  VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
            + LRATD D   N  + +S+  A      F +    G   +S    LD E+       L 
Sbjct: 603  LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGR--LSTISSLDREE--QAFYSLL 658

Query: 641  VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
            V+A D G+PP +S   + + + D NDN P F    YF  + EN   G+ +  ++ATD D 
Sbjct: 659  VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDL 718

Query: 701  SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
                G      S    ++F++NA+SG I+T   LDRE K+ Y L + A DG  G+ Q   
Sbjct: 719  GTN-GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDG--GNLQSPN 775

Query: 761  IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 820
             A V IT+LD  DN P +    Y   + E       V +V A   DL  N + + +    
Sbjct: 776  QAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQ 835

Query: 821  NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNL 880
               +++N  TG++ TT  ++DRE    ++     K+V S           T    V + +
Sbjct: 836  KGMFAINQVTGQL-TTANVIDREEQSFYQL----KVVASGG-------TVTGDTMVNITV 883

Query: 881  LDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 940
             DLNDN P F        V+E   AG SI+Q  A+D DEG+NG+V Y +    P+  F I
Sbjct: 884  KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQN-PKNLFAI 942

Query: 941  NSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVY 1000
            N  +G +     LD      YQ+ ++ASD G P  SS+  LT++V DVND +P F    Y
Sbjct: 943  NEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSY 1001

Query: 1001 NVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDR 1060
             V++SE  P   R   +  +D D G N E++Y I  GN    F + + D  +     LDR
Sbjct: 1002 EVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGI-FPDGQLYIKSELDR 1060

Query: 1061 ETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL--DVNDNRPIFLQSSYEASVPEDIPEG 1118
            E    Y+L++ A D          +ATV VTV+  DVNDNRP+F  ++Y     E+   G
Sbjct: 1061 ELQDRYVLMVVASDRAV----EPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAG 1116

Query: 1119 HSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE----RNSSH 1174
              + ++ A D D G  G V Y         +F +H  +G +       DRE    R  + 
Sbjct: 1117 SFVGKVSAVDKDFGPNGEVRYSFEMVQ--PDFELHAISGEI-TNTHQFDRESLMRRRGTA 1173

Query: 1175 VLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVV 1231
            V        D G   P++    V VY++DIND AP F +  Y +  + E+A   T V+ V
Sbjct: 1174 VFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFY-QATISESAANLTQVLRV 1232

Query: 1232 QATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAP 1290
             A+D D G+ GL++Y I+ G  E +F ID ++G +  +  LDYE   +Y + + A D   
Sbjct: 1233 SASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGT 1292

Query: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1350
                  C++ I +L+E D    F  ++    +LEN+ +G  +  V A   D+ +     +
Sbjct: 1293 IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADL-Y 1351

Query: 1351 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVL 1409
             + T T     F I   TG I +   +D E    Y L + A D G P   ST+ V I V 
Sbjct: 1352 YSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411

Query: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
            D NDN P F    D   SI E+ P+G  V +V A DPDA  NGQ+ +++      G    
Sbjct: 1412 DFNDNPPSFP-PGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRG--NH 1468

Query: 1470 VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQ-VTIL--DINDNPPV 1526
             T ++  G ++    +DRE  + + L V A+D+  P   + + L+ VTIL  D+NDN P+
Sbjct: 1469 FTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPM 1528

Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIA 1586
              S     ++ + +   G+ +  + A D D G N  + Y I  G+ D  F +DR SG++ 
Sbjct: 1529 FISQNA--LAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD-TFIVDRYSGDL- 1584

Query: 1587 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646
             R A      Q  Y+L+ +  D G     +TT   +TI+ +  + P+F QP Y  +L EG
Sbjct: 1585 -RVASALVPSQLIYNLIVSATDLGPERRKSTTE--LTIILQGLDGPVFTQPKYITILKEG 1641

Query: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAIVA-----GNIVNTFRIDRHMGVITAAKELDYE 1701
             + + T++I+I+A     G    V Y IV+       +   F I RH G+I  A  LD E
Sbjct: 1642 -EPIGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE 1699

Query: 1702 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
                 Y + V A ++        T    V + + DINDN P FP D            G 
Sbjct: 1700 QGACLYLVDVYAIEKSTAFPR--TQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757

Query: 1762 RVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
            ++    A D D G N  V Y+I+ G     F I P  G L   +   LDRE  + Y+L +
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISGAD-DSFRIDPESGDLIATR--RLDRERRSKYSLLV 1814

Query: 1822 CARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
             A D G+   SS M + I V D+ND+ P       +  I E++   S VA +LA+D DSG
Sbjct: 1815 RA-DDGLQ--SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSG 1871

Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRD 1941
             N  +T+ +   + +  FF+N  TG+  + R LD E    Y LT+  +D        R  
Sbjct: 1872 VNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVY 1931

Query: 1942 YDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001
            +++L     D NDN P+F+ ++Y   +MEN P G+ + V N      DAD  I + +TY 
Sbjct: 1932 FNIL-----DVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN----VTDADDGINSQLTYS 1982

Query: 2002 LLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE-DIGLLNSTAHLLITI 2059
            +    S G F ++ + GV+ V   +  + ++F   ++++  L +       STA + I +
Sbjct: 1983 IASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIIL 2041

Query: 2060 LDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIH 2119
            LD NDN PTF    LT ++ EN P    V +  ATD DSG N  + Y +     ++F I 
Sbjct: 2042 LDVNDNPPTFLSPKLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIG 2100

Query: 2120 LVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
             + G +R+    +DREE  +Y LTVVATD+G   LS +  V +++ DIND+ P F   + 
Sbjct: 2101 TIDGEVRL-TGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALY 2159

Query: 2180 TVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
             V + E+   GT I  + A D D   N ++ Y IV             N    F ++  T
Sbjct: 2160 KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN-----------GNTNQEFRIDSVT 2208

Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
            G++ V  P++RE   TY +T+   D  S  P    S     +++ +LD+ND  P F+   
Sbjct: 2209 GAITVAKPLDREKTPTYHLTVQATDRGS-TPRTDTST----VSIVLLDINDFVPVFE--- 2260

Query: 2298 ITYYMERILEG-ATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIA 2356
            ++ Y   + E   T   T++ V A D D+G N  ++Y L          L  S++G++  
Sbjct: 2261 LSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL--SASGELGV 2318

Query: 2357 NRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
             +++D E        + A+D+GSP       + + + D+NDN P F   +Y   + ED P
Sbjct: 2319 TQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAP 2378

Query: 2417 VGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTAL 2476
             GT +L V A+DAD+   A+I   +  G S+F INP+TG I   + LDRE KD+Y L  +
Sbjct: 2379 TGTDVLLVNASDADASKNAVIR--IIGGNSQFTINPSTGQIITSALLDRETKDNYTLVVV 2436

Query: 2477 AKD--NPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMAT 2534
              D  +P  ++S     S  V++ V DVND  P+F    + T +      G+ V  +  T
Sbjct: 2437 CSDAGSPEPLSS-----STSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2491

Query: 2535 DQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGT 2594
            D D GPN EL YSL G   E FH+D   G +    PL    + + +V   DGG  P   +
Sbjct: 2492 DADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDS 2551

Query: 2595 TMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2654
            T + V  ++  D     VR    T +      P    V  +  T     L G    S+  
Sbjct: 2552 TTVTVRFVNKADFPK--VRAKEQTFM-----FPENQPVSSLVTTITGSSLRGE-PMSYYI 2603

Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
             +GN     F ID ++G +  +Q LD E    Y + + A D G P P+ + + L + + D
Sbjct: 2604 ASGNLG-NTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP-PFSSYEKLDITVLD 2661

Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
            ++DN P+F   P  S   + L     SPR  L      A+D D GPN  + Y I  GN E
Sbjct: 2662 VNDNAPIFKEDPFISEILENL-----SPRKIL---TVSAMDKDSGPNGQLDYEIVNGNME 2713

Query: 2775 KNFHL-QPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVR 2833
             +F +    G +  +R LDRE+ + +   +K+S   S      PS +       T  +V 
Sbjct: 2714 NSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS------PSQS-------TSVKVM 2760

Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
            + + D ND  PRF++  ++A V  ++ +G  + +V   D DIG N++  YSI+
Sbjct: 2761 INILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM 2812



 Score = 1024 bits (2648), Expect = 0.0
 Identities = 894/2943 (30%), Positives = 1374/2943 (46%), Gaps = 227/2943 (7%)

Query: 39   YLLISEDTPVGSSVTQLLAQDMD----NDPLVFGVSGEEASRFFAVE----PDTGVVWLR 90
            Y  + E+  VG+ V  L   D D    N  +   + G    R F V+    P+  ++ + 
Sbjct: 364  YASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVA 423

Query: 91   QPLDRETKSEFTVEFSVSDHQGV----------ITRKVNIQVGDVNDNAPTFHNQPYSVR 140
              LDRE    + +  SVSD+ G               + I V D+ND+ P F  Q Y V 
Sbjct: 424  SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483

Query: 141  IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRE--LDYE 196
            + E  P G+ +  ++ATD D G   ++ YS    +   +F I    G+VT      LD E
Sbjct: 484  LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543

Query: 197  TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-YSTNIYEHSPPGTTV 255
                  L ++A DQ    P  + A L + + DV D  P+F     Y  ++ E++P GT +
Sbjct: 544  LASQIVLNISARDQG-VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602

Query: 256  RIITAIDQDKGRPRGIGYTIVSGNTNS-IFALDYISGVLTLNGLLDRENPLYSHGFILTV 314
             ++ A D D G    + +++    T+   F LD +SG L+    LDRE   +   + L V
Sbjct: 603  LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAF---YSLLV 659

Query: 315  KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVV 374
              T+L      S A +    N+ ++DINDN+P F   +Y   I E    G  +     V 
Sbjct: 660  LATDLGSPPQSSMARI----NVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---VS 712

Query: 375  DKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
              D +LG N   +  +   +   F ++  S      I  R+A  LD E    Y   + A 
Sbjct: 713  ATDPDLGTNGTVKYSISAGDRSRFQVNAQS----GVISTRMA--LDREEKTAYQLQIVAT 766

Query: 435  ESVP-DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
            +         A V IT+++  DN P+FSQ  Y+  ++ENV +G  V +V A+  D  +  
Sbjct: 767  DGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNS-- 824

Query: 494  EVSYFFS--DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINV 551
             +SY  +  D    F++++ TG +     +D E    + L ++A  GG       V I V
Sbjct: 825  NISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-SGGTVTGDTMVNITV 883

Query: 552  LDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFD 611
             D+NDN P F +      + EN  +   + + +A D D   N  + YS+       + F 
Sbjct: 884  KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPK--NLFA 941

Query: 612  ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 671
            I+  E  G IS+  PLD   +  G   + ++A D G P L+S+V +T+ V D NDN P F
Sbjct: 942  IN--EKNGTISLLGPLD---VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVF 996

Query: 672  SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINA-RSGEIT 729
             + +Y V++ E+    +    + A+D D         I Y++ EG+T         G++ 
Sbjct: 997  DQLSYEVTLSESEPVNSRFFKVQASDKDSG---ANGEIAYTIAEGNTGDAFGIFPDGQLY 1053

Query: 730  TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL--DINDNHPTWKDAPYYINL 787
              S LDRE +  Y+L+V A D  V    +   ATVN+T++  D+NDN P +    Y    
Sbjct: 1054 IKSELDRELQDRYVLMVVASDRAV----EPLSATVNVTVILEDVNDNRPLFNSTNYTFYF 1109

Query: 788  VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
             E     S V  V AVD D G NG + YS +     + L++ +G+I  TH   DRE+   
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTH-QFDRESLMR 1168

Query: 848  HEAELMRKIVVSVTDCGRP-PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
                 +    V  TD G P PLK    ATV V + D+NDN P F    + A + E     
Sbjct: 1169 RRGTAVFSFTVIATDQGIPQPLK--DQATVHVYMKDINDNAPKFLKDFYQATISESAANL 1226

Query: 907  VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
              + +V A D+DEG NGL+ Y +  G     F I+S+SG V    +LD E    Y L + 
Sbjct: 1227 TQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQ 1286

Query: 967  ASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGL 1026
            A D+GT   +ST TL I +LD ND TP+F  +   V V E++     V  +  TD+D G 
Sbjct: 1287 AVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGD 1346

Query: 1027 NAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
            NA+L Y ITG N  G FS+      +     LD ET + Y L + A D G   +  + T 
Sbjct: 1347 NADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR--SSTM 1404

Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-N 1145
            +V + V D NDN P F       S+ E+IP G S++ + A D D    G++ Y I+    
Sbjct: 1405 SVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMP 1464

Query: 1146 HGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS----VRVIVYVEDI 1201
             GN+F I    G +      +DRE  +   L V+A N    P+ +       V + V D+
Sbjct: 1465 RGNHFTIDEVKGTIYTNAE-IDREFANLFELTVKA-NDQAVPIETRRYALKNVTILVTDL 1522

Query: 1202 NDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDES 1261
            ND  P+F  Q  + L    +A IG+ +  + A D D G  G + Y I++G    F +D  
Sbjct: 1523 NDNVPMFISQ--NALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRY 1580

Query: 1262 TGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
            +G +   + L   ++  Y + VSATD  P   +    + I +L  LD  V F+   Y   
Sbjct: 1581 SGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTI-ILQGLDGPV-FTQPKYITI 1637

Query: 1322 ILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKA---LFKIDAITGVITVQGLVD 1378
            + E   +GT ++ ++A S          +      + K    LF I   TG+I    ++D
Sbjct: 1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697

Query: 1379 REKGD-FYTLTVVADDGGPKVDST--VKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG 1435
            RE+G   Y + V A +       T   +V IT+ D NDN P F  T    +++ E+   G
Sbjct: 1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFP-TDMLDLTVEENIGDG 1756

Query: 1436 QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYIL 1495
             ++  + A D D G+N  V +++    I+GA +    +   G++   R LDRE    Y L
Sbjct: 1757 SKIMQLTAMDADEGANALVTYTI----ISGADDSFRIDPESGDLIATRRLDRERRSKYSL 1812

Query: 1496 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
             V A D     +  D  + +T+ D+ND+ P    P  Y+  + E+   G+ V  + ATD 
Sbjct: 1813 LVRADD---GLQSSDMRINITVSDVNDHTPKFSRPV-YSFDIPEDTIPGSLVAAILATDD 1868

Query: 1556 DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS 1615
            D G+N  ++Y + E ++D  F ++ I+G +       D E Q +Y L    ED G     
Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITG-VFNLTRLLDYEVQQYYILTVRAEDGGGQ--F 1925

Query: 1616 ATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675
             T  VY  I+D NDN P+F    Y   L E     +T L+     D D+G N  +TY+I 
Sbjct: 1926 TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLV-FNVTDADDGINSQLTYSIA 1984

Query: 1676 AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVN 1735
            +G+ +  F +D++ GV+   K LD E S   Y L+V   D   I + R TST  V + + 
Sbjct: 1985 SGDSLGQFTVDKN-GVLKVLKALDRE-SQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL 2042

Query: 1736 DINDNVPTF--PRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLG-E 1791
            D+NDN PTF  P+       + E  P    V+   A D DSGPN  +EY+++  +PLG +
Sbjct: 2043 DVNDNPPTFLSPK----LTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL--NPLGNK 2096

Query: 1792 FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVL 1851
            F I  ++G   VR   ELDRE ++ Y LT+ A D+G P LSS+  V + VLDINDN+P+ 
Sbjct: 2097 FSIGTIDG--EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIF 2154

Query: 1852 LNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVN 1911
                  + I+EN+   + +  V A+D D G N ++ + I  GN  + F I++ TG +TV 
Sbjct: 2155 AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVA 2214

Query: 1912 RPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN 1971
            +PLDRE+ P Y LT+   D    P   R D   + I L D ND  P+F  S Y   V EN
Sbjct: 2215 KPLDREKTPTYHLTVQATDRGSTP---RTDTSTVSIVLLDINDFVPVFELSPYSVNVPEN 2271

Query: 1972 SPAGT-PLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDR 2029
               GT P T+L   ++A D D+   + ++Y L G  +   F +++S  +   +S   +DR
Sbjct: 2272 --LGTLPRTILQ--VVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQS---LDR 2324

Query: 2030 EAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
            E     +L +         L  T  + + + D NDN PTF+       + E+ P G  VL
Sbjct: 2325 ETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVL 2384

Query: 2090 QVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDR 2149
             V A+D D+  N   V RI  G   +F I+  TG I + +A +DRE +++Y L VV +D 
Sbjct: 2385 LVNASDADASKNA--VIRI-IGGNSQFTINPSTGQI-ITSALLDRETKDNYTLVVVCSDA 2440

Query: 2150 GT-VPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLE 2208
            G+  PLS +  V + + D+ND+ P F +      +     PG+ +  +T  D D+ P  E
Sbjct: 2441 GSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSE 2500

Query: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSV-IDNASDL 2267
             H            L     + F ++   G++M   P+N       EVT SV + +    
Sbjct: 2501 LHY----------SLSGRNSEKFHIDPLRGAIMAAGPLN----GASEVTFSVHVKDGGSF 2546

Query: 2268 PERSVSVPNAKLTVNVLDVND-NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKG 2326
            P+          TV V  VN  + P+ +    T+        ++  TT+           
Sbjct: 2547 PKTD------STTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITG-------SS 2593

Query: 2327 LNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEI 2386
            L G      +     G     D   G+V  ++ +D+E++      + A D G PP ++  
Sbjct: 2594 LRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYE 2653

Query: 2387 PVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDG 2444
             + + ++D+NDN PIF +  +   + E++     ILTV+A D DSG    ++Y +  G+ 
Sbjct: 2654 KLDITVLDVNDNAPIFKEDPFISEILENLSPRK-ILTVSAMDKDSGPNGQLDYEIVNGNM 2712

Query: 2445 ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVND 2504
            E+ F+IN  TG+I  +  LDREK  HY+LT  + D      S  +  SV+V+I +LD ND
Sbjct: 2713 ENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK----GSPSQSTSVKVMINILDEND 2768

Query: 2505 CRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGL 2564
              P+FS+  FS  V EN P G +V  +  +D+D G N    YS+    +  F ++  +G 
Sbjct: 2769 NAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASL-PFTINPSTGD 2826

Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWG-TTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
            +   RPL  +  +++ + V A D G    W  +T + + V D+NDN P F R      L 
Sbjct: 2827 IVISRPLNREDTDRYRIRVSAHDSG----WTVSTDVTIFVTDINDNAPRFSR--TSYYLD 2880

Query: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDR 2681
              E   + S V +V+ATD DEG NG V Y F+K+      E+F I+  +G I   Q L  
Sbjct: 2881 CPELTEIGSKVTQVFATDPDEGSNGQVFY-FIKSQS----EYFRINATTGEIFNKQILKY 2935

Query: 2682 ESQAVY--------SLILVASDLGQP-VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
            ++   +        S I+ +SD G+P +  ET   + +   D +DN P F++    +P  
Sbjct: 2936 QNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV--DSNDNAPQFLKSKYFTP-- 2991

Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDL 2791
                V ++   GT +  VT   D D G N+ V YFI+  N    F L  D G + V   L
Sbjct: 2992 ----VTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSL 3047

Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
              +     +F +  ++     PP     T           V + + + N   P F+++  
Sbjct: 3048 ISDLNQ--NFFITVTAKDKGNPPLSSQAT-----------VHITVTEENYHTPEFSQSHM 3094

Query: 2852 TAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
            +A +     +GS +  V A D D   N L+ YSI            S +   +F + S  
Sbjct: 3095 SATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI-----------SSGNEEGIFAINSST 3143

Query: 2912 GIL 2914
            GIL
Sbjct: 3144 GIL 3146



 Score = 1020 bits (2638), Expect = 0.0
 Identities = 883/2908 (30%), Positives = 1371/2908 (47%), Gaps = 222/2908 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQP--LDRE 96
            +SE+ P GS V+ + A D D   N  L + +       +F +   +G+V       LDRE
Sbjct: 484  LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543

Query: 97   TKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP--YSVRIPENTPVGTPI 151
              S+  +  S  D   H  V   ++ + + DVND  P F +QP  Y V + EN P GT +
Sbjct: 544  LASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVF-SQPEGYDVSVVENAPTGTEL 602

Query: 152  FIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
             ++ ATD DLG  G+V +S Q      + F +D   G ++ I  LD E    Y L V AT
Sbjct: 603  LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLAT 662

Query: 209  DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
            D     P S++A + + + D+ D  P+F  + Y  +I E+ P G+ +  ++A D D G  
Sbjct: 663  DLGSP-PQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721

Query: 269  RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
              + Y+I +G+  S F ++  SGV++    LDRE       + L +  T+  + ++P+ A
Sbjct: 722  GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKT---AYQLQIVATDGGNLQSPNQA 777

Query: 329  TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFE 387
             VT T    V+D  DN P F+   YS  + E   +G+ +  +    +D + N+       
Sbjct: 778  IVTIT----VLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNIS------ 827

Query: 388  VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
             YL+       + +   V G+    +  A  +D E    Y   + A+       G   V 
Sbjct: 828  -YLITTGDQKGMFAINQVTGQ----LTTANVIDREEQSFYQLKVVASGGTV--TGDTMVN 880

Query: 448  ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR-F 506
            IT+ + NDN P F Q + ++++ EN   G S+    A D D G  G V Y    +P   F
Sbjct: 881  ITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLF 940

Query: 507  SLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKD 564
            ++++  G I L+  LD      + + I+A D G  + +  V + V   DVNDN P F + 
Sbjct: 941  AINEKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL 999

Query: 565  AYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS---AFGSYFDISLYEGYGVI 621
            +Y   L E+EP  ++  +++A+D+DS  N +I Y+I   +   AFG + D  LY      
Sbjct: 1000 SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLY------ 1053

Query: 622  SVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
             +   LD E     +  L V+A D    PL++TV VT+ + D NDN P F+   Y     
Sbjct: 1054 -IKSELDRELQDRYV--LMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFE 1110

Query: 682  ENIMAGATVLFLNATDLDRSREYGQESII-YSLEG-STQFRINARSGEITTTSLLDRET- 738
            E   AG+ V  ++A D D    +G    + YS E     F ++A SGEIT T   DRE+ 
Sbjct: 1111 EEQRAGSFVGKVSAVDKD----FGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESL 1166

Query: 739  -----KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
                  + +   V A D G+    K   ATV++ + DINDN P +    Y   + E    
Sbjct: 1167 MRRRGTAVFSFTVIATDQGIPQPLKDQ-ATVHVYMKDINDNAPKFLKDFYQATISESAAN 1225

Query: 794  DSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
             + V  V A D D G NG + YSI   N  + ++++ST+G++ T    LD      +EA 
Sbjct: 1226 LTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQV-TLIGKLD------YEAT 1278

Query: 852  LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
                +V+   D G  PL +T   T+ +++LD NDN P+F       +VLE +  G  +  
Sbjct: 1279 PAYSLVIQAVDSGTIPLNST--CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSS 1336

Query: 912  VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG 971
            V A D D G N  + Y +        F I+ ++G +    +LD E  + Y+L + A D G
Sbjct: 1337 VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQG 1396

Query: 972  TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
             P +SST ++ IHV D ND  P+F P     S+ E++P    V+ +   D D  +N +LS
Sbjct: 1397 RPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLS 1456

Query: 1032 YFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVF 1089
            Y I      G  F++      + T   +DRE    + L ++A D   P+  R      V 
Sbjct: 1457 YTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVT 1516

Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN 1149
            + V D+NDN P+F+  +  A+ P  +  G  +  + A D DEG  G + Y I++G+  + 
Sbjct: 1517 ILVTDLNDNVPMFISQNALAADPSAVI-GSVLTTIMAADPDEGANGEIEYEIINGDT-DT 1574

Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR--SSVRVIVYVEDINDEAPV 1207
            F +   +G L      +  +    + LIV A   DLGP R  S+  + + ++ +  + PV
Sbjct: 1575 FIVDRYSGDLRVASALVPSQL--IYNLIVSAT--DLGPERRKSTTELTIILQGL--DGPV 1628

Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-----FEIDEST 1262
            FTQ +Y  + L+E   IGT+VI ++A      +  +  Y +    E K     F I   T
Sbjct: 1629 FTQPKYITI-LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHT 1687

Query: 1263 GLIITVNYLDYETKTS-YMMNVSATDQAPPFNQGF-CSVYITLLNELDEAVQFSNASYEA 1320
            G+I T   LD E     Y+++V A +++  F +     V ITL +  D    F     + 
Sbjct: 1688 GIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDL 1747

Query: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
             + EN+  G++I+++ A   D        +   +   A   F+ID  +G +     +DRE
Sbjct: 1748 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG--ADDSFRIDPESGDLIATRRLDRE 1805

Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
            +   Y+L V ADDG    D  +++ ITV D ND++P+F     S   IPED   G  VA 
Sbjct: 1806 RRSKYSLLVRADDGLQSSD--MRINITVSDVNDHTPKFSRPVYS-FDIPEDTIPGSLVAA 1862

Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
            + A D D+G NG++ + +   +  G F +   N   G   + R LD E   +YIL V A 
Sbjct: 1863 ILATDDDSGVNGEITYIVNEDDEDGIFFL---NPITGVFNLTRLLDYEVQQYYILTVRAE 1919

Query: 1501 DRG---TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDI 1557
            D G   T  R     +   ILD+NDNPP+  S   Y+ S+ EN+  G+ V+    TD D 
Sbjct: 1920 DGGGQFTTIR-----VYFNILDVNDNPPIF-SLNSYSTSLMENLPVGSTVLVFNVTDADD 1973

Query: 1558 GINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG---TPTL 1614
            GINS L+Y I  G+    F +D+ +G +    A  DRE QSFY+LV  V D         
Sbjct: 1974 GINSQLTYSIASGDSLGQFTVDK-NGVLKVLKAL-DRESQSFYNLVVQVHDLPQIPASRF 2031

Query: 1615 SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI 1674
            ++T  V + ++D NDN P F  P    + +  P  ++T +   QA D D GPN  + Y +
Sbjct: 2032 TSTAQVSIILLDVNDNPPTFLSPKLTYIPENTP--IDTVVFKAQATDPDSGPNSYIEYTL 2089

Query: 1675 VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNV 1734
            +   + N F I    G +    ELD E     YTL V ATD+       L+S+T V+V V
Sbjct: 2090 L-NPLGNKFSIGTIDGEVRLTGELDRE-EVSNYTLTVVATDKG---QPSLSSSTEVVVMV 2144

Query: 1735 NDINDNVPTFPRDYEGPFEVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
             DINDN P F +      E+ E    G  +    A D D G NGQV Y I++G+   EF 
Sbjct: 2145 LDINDNNPIFAQALY-KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFR 2203

Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
            I  V G + V K   LDRE    Y+LT+ A DRG  P + T  V I +LDIND  PV   
Sbjct: 2204 IDSVTGAITVAKP--LDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFEL 2261

Query: 1854 LPMNITISEN-SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNR 1912
             P ++ + EN   +   +  V+A D D G N++L++ +  GN + AF ++A+ G + V +
Sbjct: 2262 SPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSAS-GELGVTQ 2320

Query: 1913 PLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
             LDRE    + L I+  D+      A      + + + D NDN P F    Y   + E++
Sbjct: 2321 SLDRETKERFVLMITATDSGSP---ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDA 2377

Query: 1973 PAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAF 2032
            P GT + ++N    A DAD    AV+  +++G  S  F IN STG +   +  ++DRE  
Sbjct: 2378 PTGTDVLLVN----ASDADASKNAVI--RIIGGNSQ-FTINPSTGQII--TSALLDRE-- 2426

Query: 2033 SPPILELLLLAEDIGL---LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
            +     L+++  D G    L+S+  +L+T+ D NDN P F       H+     PG  V 
Sbjct: 2427 TKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVF 2486

Query: 2090 QVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDR 2149
             VT TD D G N EL Y +     ++F I  + G I          E      +V   D 
Sbjct: 2487 AVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASE---VTFSVHVKDG 2543

Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEY 2209
            G+ P + +  VT+   +  D  P+     QT    E+    +++  IT       P   Y
Sbjct: 2544 GSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYY 2602

Query: 2210 HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
               G            N  + F ++  TG V +  P++ E +  Y V +   D     P 
Sbjct: 2603 IASG------------NLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP-PF 2649

Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
             S      KL + VLDVNDN P FK      ++  ILE  +P   ++ V+A+D D G NG
Sbjct: 2650 SSYE----KLDITVLDVNDNAPIFKE---DPFISEILENLSP-RKILTVSAMDKDSGPNG 2701

Query: 2330 LVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVY 2389
             + Y +++        +  ++ G++ + R +D E+V     T+++SD GSP ++  + V 
Sbjct: 2702 QLDYEIVNGNMENSFSINHAT-GEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVM 2760

Query: 2390 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFA 2449
            + I+D NDN P F Q  +   V E+ P+G  +  VT +D D G  A+  YS+ D    F 
Sbjct: 2761 INILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFT 2819

Query: 2450 INPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
            INP+TGDI +   L+RE  D Y +   A D+   V       S  V I V D+ND  P+F
Sbjct: 2820 INPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV-------STDVTIFVTDINDNAPRF 2872

Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQR 2569
            S+  +     E    G+ V  + ATD DEG NG++ Y ++    E F ++  +G +  ++
Sbjct: 2873 SRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS-EYFRINATTGEIFNKQ 2931

Query: 2570 PLQ----------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
             L+          +  + S  V ++D G+P L   T + + ++D NDN P F++    T 
Sbjct: 2932 ILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFT- 2990

Query: 2620 LHIREEIPLRSNVYEVYATD-KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
              + + + + + +  V A D KD GLN  V Y     + +     F +D  +G I  A  
Sbjct: 2991 -PVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI---SNDNHLGKFKLDNDTGWISVASS 3046

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L  +    + + + A D G P P  +   + + + + + + P F      S  +   T+P
Sbjct: 3047 LISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEF------SQSHMSATIP 3099

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREA 2797
            E    G++V  V+ A D D   N ++ Y I++GNEE  F +    G L + + LD E   
Sbjct: 3100 ESHSIGSIVRTVS-ARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQ 3158

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
                 + A     W            VA      V V + D+ND  P F   +Y   V  
Sbjct: 3159 KHEMTISAIDG-GW------------VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSI 2885
            +A  G+ +I + A DAD G N+++ Y++
Sbjct: 3206 NAPSGTTVIHLNATDADSGTNAVIAYTV 3233



 Score = 1020 bits (2637), Expect = 0.0
 Identities = 889/2903 (30%), Positives = 1338/2903 (46%), Gaps = 225/2903 (7%)

Query: 69   VSGEEASRF---FAVEPDTGVVWL----RQPLDRETKSEFTVEFSVSDHQGVITR---KV 118
            + G EA RF     + P     +L    +  LDRE   ++ +   V D      R   +V
Sbjct: 177  IRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQV 236

Query: 119  NIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFF 178
            N+ V D+NDN P F +  Y   +PE+  VG+ +  V A D D G    + Y  Q     F
Sbjct: 237  NVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPF 296

Query: 179  AIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI--F 236
             +D   G++TV   LD+E  + Y LTV A D+     L+  A   I + DV D DP+  F
Sbjct: 297  QMDPETGLITVREPLDFEARRQYSLTVQAMDRG-VPSLTGRAEALIQLLDVNDNDPVVKF 355

Query: 237  INLPYST---NIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIFALDYIS-- 290
               P ++   ++ E++  GT V ++T  D D     G I   I+ GN    F +      
Sbjct: 356  RYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVP 415

Query: 291  --GVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDA----TVTTTFNILVIDIND 343
               ++ +   LDRE  P Y+    LTV  ++ N    P  A    +   +  I V DIND
Sbjct: 416  NLSLIKVASALDRERIPSYN----LTVSVSD-NYGAPPGAAVQARSSVASLVIFVNDIND 470

Query: 344  NAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN------SHH 397
            + P F+   Y V ++E A  G +    I   D D  L  N  + + + GN       S H
Sbjct: 471  HPPVFSQQVYRVNLSEEAPPG-SYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISEH 528

Query: 398  FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
              +  T   G  D  +   I L+    D         + V   V YA++ +TL++ ND +
Sbjct: 529  SGLVTTGSSGGLDRELASQIVLNISARD---------QGVHPKVSYAQLVVTLLDVNDEK 579

Query: 458  PIFSQPL-YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD---DPDRFSLDKDTG 513
            P+FSQP  Y++S+ EN   GT +L + ATD D G  G V +   +   D   F LD  +G
Sbjct: 580  PVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG 639

Query: 514  LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINV--LDVNDNVPTFQKDAYVGALR 571
             +  I+ LD E    ++L ++A D G    +   RINV  LD+NDN P F    Y   ++
Sbjct: 640  RLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIK 699

Query: 572  ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
            ENEP  + +  + ATD D   N  + YSI +     S F ++     GVIS    LD E+
Sbjct: 700  ENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR--SRFQVNAQS--GVISTRMALDREE 755

Query: 632  ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
                   L ++A D GN    +   VTI V D  DNPP FS+ AY   V EN+  G  V 
Sbjct: 756  --KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVG 813

Query: 692  FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDG 751
             ++A+ +D +       +I + +    F IN  +G++TT +++DRE +S Y L V A  G
Sbjct: 814  SVSASTMDLNSNISY--LITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG 871

Query: 752  GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
             V     TG   VNIT+ D+NDN P +  A   +N+VE       +    AVDPD G NG
Sbjct: 872  TV-----TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNG 926

Query: 812  TLVYSI-QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
             ++YS+ Q P   +++N   G I     +      D H      +I+ S  D G P L +
Sbjct: 927  MVLYSLKQNPKNLFAINEKNGTISLLGPL------DVHAGSYQIEILAS--DMGVPQLSS 978

Query: 871  TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
            +   TV+V+  D+NDN P F  L +   + E  P     ++V A D D G NG ++Y + 
Sbjct: 979  SVILTVYVH--DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIA 1036

Query: 931  VGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
             G     F I    G +   +ELDRE    Y L VVASD      S+T  +T+ + DVND
Sbjct: 1037 EGNTGDAFGI-FPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVND 1095

Query: 991  ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDA 1050
              P F    Y     E+      V  ++  D D G N E+ Y      V   F +     
Sbjct: 1096 NRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFE--MVQPDFELHAISG 1153

Query: 1051 VVRTVVGLDRET------TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
             +      DRE+      TA +   + A D G + +     ATV V + D+NDN P FL+
Sbjct: 1154 EITNTHQFDRESLMRRRGTAVFSFTVIATDQG-IPQPLKDQATVHVYMKDINDNAPKFLK 1212

Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
              Y+A++ E       +L++ A+D DEG  G + Y I+ GN    F I  ++G +    +
Sbjct: 1213 DFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGK 1272

Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
             LD E   ++ L+++A +    P+ S+  + + + D ND  P F +     + + E   I
Sbjct: 1273 -LDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLF-VDVLENMRI 1330

Query: 1225 GTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
            G  V  V ATD DSGD   + Y I  +   G F I  +TG I     LD+ET++ Y +N+
Sbjct: 1331 GELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNI 1390

Query: 1284 SATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNL 1343
            +A DQ  P      SV I + +  D    F       +I+EN+ +GT ++ V A+  D  
Sbjct: 1391 TAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450

Query: 1344 NQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD---- 1399
                  +           F ID + G I     +DRE  + + LTV A+D    ++    
Sbjct: 1451 INGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRY 1510

Query: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLA 1459
            +   V I V D NDN P   F S +A++      +G  + T+ A DPD G+NG++ + + 
Sbjct: 1511 ALKNVTILVTDLNDNVPM--FISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEII 1568

Query: 1460 SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
            +G+     +    +   G++ VA  L   +L  Y L V A+D G  P ++    ++TI+ 
Sbjct: 1569 NGDT----DTFIVDRYSGDLRVASALVPSQL-IYNLIVSATDLG--PERRKSTTELTIIL 1621

Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-----EGNKDM 1574
               + PV   P  Y   + E    GT V+ + A     G  + + YYI      E     
Sbjct: 1622 QGLDGPVFTQP-KYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGR 1679

Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT--THVYVTIVDENDNAP 1632
             F + R +G I T  A  DRE+ +  +LV     E +     T    V +T+ D NDN P
Sbjct: 1680 LFTIGRHTGIIQT-AAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPP 1738

Query: 1633 MFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVI 1692
            +F     ++ ++E      + ++ + A+D DEG N  VTY I++G   ++FRID   G +
Sbjct: 1739 VFPTDMLDLTVEENIGD-GSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDL 1796

Query: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF 1752
             A + LD E    +Y+L+V A D         +S   + + V+D+ND+ P F R     F
Sbjct: 1797 IATRRLDRE-RRSKYSLLVRADDGLQ------SSDMRINITVSDVNDHTPKFSRPVYS-F 1848

Query: 1753 EVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
            ++ E   PG  V   LA D DSG NG++ Y + + D  G F ++P+ GV  + +   LD 
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTR--LLDY 1906

Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871
            E   +Y LT+ A D G     +T+ V   +LD+NDN P+      + ++ EN PV S V 
Sbjct: 1907 EVQQYYILTVRAEDGG--GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVL 1964

Query: 1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
                +DAD G N++LT++I +G+    F ++   G++ V + LDRE    Y L + V D 
Sbjct: 1965 VFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDL 2023

Query: 1932 PENPRIARRDYDLLLIFLSDENDNHPLF--TKSTYQAEVMENSPAGTPLTVLNGPILALD 1989
            P+ P         + I L D NDN P F   K TY        P  TP+  +     A D
Sbjct: 2024 PQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-------IPENTPIDTVVFKAQATD 2076

Query: 1990 ADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLL 2049
             D    + + Y LL      F I +  G V +     +DRE  S   L ++   +    L
Sbjct: 2077 PDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE--LDREEVSNYTLTVVATDKGQPSL 2134

Query: 2050 NSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIE 2109
            +S+  +++ +LD NDN P F+ A   V + EN   G  ++QV A D D G NG++ Y I 
Sbjct: 2135 SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIV 2194

Query: 2110 AG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
             G     F I  VTG I V    +DRE+  +Y LTV ATDRG+ P + T+ V+I++ DIN
Sbjct: 2195 NGNTNQEFRIDSVTGAITVAK-PLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIN 2253

Query: 2169 DSRPEFLNPIQTVSVLESAEPGTV---IANITAIDHD--LNPKLEYHIVGIVAKDDTDRL 2223
            D  P F     +V+V E+   GT+   I  + A D D   N KL Y + G          
Sbjct: 2254 DFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLFG---------- 2301

Query: 2224 VPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
              N+++AF ++  +G + V   ++RE    + + ++  D+ S             + V V
Sbjct: 2302 -GNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGS-----PALTGTGTINVIV 2354

Query: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGY 2343
             DVNDN P    F    Y   I E A  GT ++ V A D D   N ++       +  G 
Sbjct: 2355 DDVNDNVP---TFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR------IIGGN 2405

Query: 2344 VQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPI 2401
             Q   + S G++I +  +D E        V  SD GSP P ++   V + + D+NDN P 
Sbjct: 2406 SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPR 2465

Query: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVL 2460
            F    Y   +      G+ +  VT TDAD G  + + YSL G    KF I+P  G I   
Sbjct: 2466 FQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAA 2525

Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
              L+   +  + +      +  D  S  + +S  V ++ ++  D  P+    + +    E
Sbjct: 2526 GPLNGASEVTFSV------HVKDGGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPE 2578

Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFS 2578
            N+P  + V T+  +     P     Y   G     F +D  +G V+  +PL  +  +K+ 
Sbjct: 2579 NQPVSSLVTTITGSSLRGEPMS--YYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYV 2636

Query: 2579 LTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
            + + A DGG PP      L + V+DVNDN P+F   P   I  I E +  R  +  V A 
Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDP--FISEILENLSPR-KILTVSAM 2693

Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
            DKD G NG + Y  +   GN +   F I+  +G I++ + LDRE  + Y L + +SD G 
Sbjct: 2694 DKDSGPNGQLDYEIVN--GNME-NSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS 2750

Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
            P    T   + + + D +DN P F        Q     VPE+SP G  V  VT + D D 
Sbjct: 2751 P-SQSTSVKVMINILDENDNAPRF-------SQIFSAHVPENSPLGYTVTRVTTS-DEDI 2801

Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
            G NAI  Y I   +    F + P  G +++ R L+RE    +   V A  +  WT     
Sbjct: 2802 GINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDS-GWT----- 2853

Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
                         +V + + DIND  PRF++  Y        ++GS++ QV A D D G+
Sbjct: 2854 ----------VSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGS 2903

Query: 2878 NSLVFYSILA-IHYFRALANDSE 2899
            N  VFY I +   YFR  A   E
Sbjct: 2904 NGQVFYFIKSQSEYFRINATTGE 2926



 Score = 1002 bits (2591), Expect = 0.0
 Identities = 876/2928 (29%), Positives = 1356/2928 (46%), Gaps = 215/2928 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRET 97
            + E+ P G+ +  L A D D   N  + F +   E  R  F ++P +G +     LDRE 
Sbjct: 592  VVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREE 651

Query: 98   KSEFTVEFSVSD----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153
            ++ +++    +D     Q  + R +N+ + D+NDN+P F+   Y   I EN P G+ I  
Sbjct: 652  QAFYSLLVLATDLGSPPQSSMAR-INVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT 710

Query: 154  VNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
            V+ATDPDLG  G+V YS     +  F +++  G+++    LD E   AYQL + ATD   
Sbjct: 711  VSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGN 770

Query: 213  TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
             +  +  A + I + D QD  P+F  + YS  ++E+   G  V  ++A   D      I 
Sbjct: 771  LQSPNQ-AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNS--NIS 827

Query: 273  YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
            Y I +G+   +FA++ ++G LT   ++DRE   +    ++   GT   D          T
Sbjct: 828  YLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGD----------T 877

Query: 333  TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
              NI V D+NDN+P F  +  SV + E  Q G ++    + VD DE  G+N M    L  
Sbjct: 878  MVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSI-FQAKAVDPDE--GVNGMVLYSLKQ 934

Query: 393  NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLI 451
            N  + F I+      + +  I +  PLD      Y  ++ A++  VP       + + + 
Sbjct: 935  NPKNLFAIN------EKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVILTVYVH 987

Query: 452  NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLD 509
            + NDN P+F Q  Y ++L E+  V +    V A+D D+G  GE++Y  ++    D F + 
Sbjct: 988  DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIF 1047

Query: 510  KDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYV 567
             D G + + + LD EL  R+ L ++A D   E  +  V + V+  DVNDN P F    Y 
Sbjct: 1048 PD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYT 1106

Query: 568  GALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPL 627
                E + + + + ++ A D+D  PN ++ YS           D  L+   G I+ +   
Sbjct: 1107 FYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQP-----DFELHAISGEITNTHQF 1161

Query: 628  DYEQI----SNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 682
            D E +       +   TV+A D G P PL     V + + D NDN P F K  Y  ++ E
Sbjct: 1162 DRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISE 1221

Query: 683  NIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEY 742
            +      VL ++A+D+D          I       QF I++ SG++T    LD E    Y
Sbjct: 1222 SAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAY 1281

Query: 743  ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
             L+++AVD G      T   T+NI +LD NDN P++  +  +++++E       V++V A
Sbjct: 1282 SLVIQAVDSGTIPLNST--CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTA 1339

Query: 803  VDPDLGENGTLVYSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSV 860
             D D G+N  L YSI   N    +S++  TG I     +         E + + K+ ++ 
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKL-------DFETQSLYKLNITA 1392

Query: 861  TDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEG 920
             D GRPP  +T S  + V   D NDN P+F        ++E IP G S+  V A D D  
Sbjct: 1393 KDQGRPPRSSTMSVVIHVR--DFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450

Query: 921  LNGLVSYRMPVGMPRMD-FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKS--- 976
            +NG +SY +   MPR + F I+   G + T  E+DRE    ++L V A+D   P ++   
Sbjct: 1451 INGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRY 1510

Query: 977  STSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
            +   +TI V D+ND  P F  +   ++          +  +   D D G N E+ Y I  
Sbjct: 1511 ALKNVTILVTDLNDNVPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIIN 1569

Query: 1037 GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVN 1096
            G+ D  F V      +R    L   +   Y LI+ A D GP  ++ T   T+ +  LD  
Sbjct: 1570 GDTD-TFIVDRYSGDLRVASALV-PSQLIYNLIVSATDLGPERRKSTTELTIILQGLD-- 1625

Query: 1097 DNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY----RILHGNHGNNFRI 1152
               P+F Q  Y   + E  P G +++ ++A      E    +Y    R      G  F I
Sbjct: 1626 --GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTI 1683

Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFT 1209
                G++      LDRE+ +  + +V+ Y  +     P      V + ++DIND  PVF 
Sbjct: 1684 GRHTGIIQTAAI-LDREQGAC-LYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFP 1741

Query: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVN 1269
                  L + E  G G+ ++ + A D D G   LV Y I+SGA+  F ID  +G +I   
Sbjct: 1742 TDMLD-LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATR 1800

Query: 1270 YLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALG 1329
             LD E ++ Y + V A D     +     + IT+ +  D   +FS   Y   I E+   G
Sbjct: 1801 RLDRERRSKYSLLVRADDGLQSSDM---RINITVSDVNDHTPKFSRPVYSFDIPEDTIPG 1857

Query: 1330 TEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL 1387
            + +  + A   D+    +ITY  N         +F ++ ITGV  +  L+D E   +Y L
Sbjct: 1858 SLVAAILATDDDSGVNGEITYIVN---EDDEDGIFFLNPITGVFNLTRLLDYEVQQYYIL 1914

Query: 1388 TVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
            TV A+DGG +  +T++VY  +LD NDN P F   S S  S+ E+ PVG  V      D D
Sbjct: 1915 TVRAEDGGGQF-TTIRVYFNILDVNDNPPIFSLNSYST-SLMENLPVGSTVLVFNVTDAD 1972

Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
             G N Q+ +S+ASG+  G F +    D  G + V + LDRE    Y L V   D    P 
Sbjct: 1973 DGINSQLTYSIASGDSLGQFTV----DKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPA 2028

Query: 1508 KK---DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLS 1564
             +      + + +LD+NDNPP   SP      + EN    T V + +ATD D G NS + 
Sbjct: 2029 SRFTSTAQVSIILLDVNDNPPTFLSP--KLTYIPENTPIDTVVFKAQATDPDSGPNSYIE 2086

Query: 1565 YYITE--GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
            Y +    GNK   F +  I GE+       DRE  S Y L     D+G P+LS++T V V
Sbjct: 2087 YTLLNPLGNK---FSIGTIDGEVRLT-GELDREEVSNYTLTVVATDKGQPSLSSSTEVVV 2142

Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT 1682
             ++D NDN P+F Q  Y+V ++E   T  T +I + A D DEG NG V Y IV GN    
Sbjct: 2143 MVLDINDNNPIFAQALYKVEINENTLT-GTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE 2201

Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
            FRID   G IT AK LD E +   Y L V ATD+    S   T T+TV + + DIND VP
Sbjct: 2202 FRIDSVTGAITVAKPLDREKTP-TYHLTVQATDRG---STPRTDTSTVSIVLLDINDFVP 2257

Query: 1743 TFPRDYEGPFEVTE----GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVE 1798
             F      P+ V      G     +   +A D D G N ++ Y +  G+    F +S   
Sbjct: 2258 VFELS---PYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-AS 2313

Query: 1799 GVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNI 1858
            G L V +   LDRET   + L I A D G P L+ T  + + V D+NDN P   +     
Sbjct: 2314 GELGVTQS--LDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFT 2371

Query: 1859 TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER 1918
            TI E++P  + V  V ASDAD+  NA     I  GN +  F IN +TG +  +  LDRE 
Sbjct: 2372 TIPEDAPTGTDVLLVNASDADASKNA--VIRIIGGNSQ--FTINPSTGQIITSALLDRET 2427

Query: 1919 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1978
               Y L +   D      ++      +L+ ++D NDN P F    Y   +   +  G+ +
Sbjct: 2428 KDNYTLVVVCSDAGSPEPLSSSTS--VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFV 2485

Query: 1979 TVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREA-FSPPIL 2037
                  +   DAD    + + Y L G  S  F I+   G +     +    E  FS  + 
Sbjct: 2486 FA----VTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHV- 2540

Query: 2038 ELLLLAEDIGLLNSTAHLLITILDDND-NRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
                  +D G    T    +T+   N  + P       T    EN P    V  +T    
Sbjct: 2541 ------KDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITG--- 2591

Query: 2097 DSGLNGE-LVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154
             S L GE + Y I +G   + F I  +TG + +    +D E+ + Y + + A D G  P 
Sbjct: 2592 -SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQP-LDFEKIQKYVVWIEARDGGFPPF 2649

Query: 2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIV 2212
            S    + I + D+ND+ P F        +LE+  P  ++  ++A+D D  P  +L+Y IV
Sbjct: 2650 SSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILT-VSAMDKDSGPNGQLDYEIV 2708

Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                         N E++F++N  TG +    P++RE V+ Y +T+   D  S  P +S 
Sbjct: 2709 N-----------GNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS--PSQST 2755

Query: 2273 SVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVT 2332
            SV   K+ +N+LD NDN P+F       +   + E +  G T+  V   D D G+N +  
Sbjct: 2756 SV---KVMINILDENDNAPRFSQI----FSAHVPENSPLGYTVTRVTTSDEDIGINAISR 2808

Query: 2333 YTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
            Y+++D   P  +   + S G ++ +R ++ E+       V A D+G         V + +
Sbjct: 2809 YSIMDASLPFTI---NPSTGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFV 2862

Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINP 2452
             DINDN P F + SY     E   +G+ +  V ATD D G+   + Y +      F IN 
Sbjct: 2863 TDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINA 2922

Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSV----QVVIQVLDVNDCRPQ 2508
            TTG+I+    L  +    +    + + +    +S+R + S+     V I ++D ND  PQ
Sbjct: 2923 TTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQ 2982

Query: 2509 FSKPQFSTSVYENEPAGTSVITMMATD-QDEGPNGELTYSLEGPG-VEAFHVDMDSGLVT 2566
            F K ++ T V +N   GT +I + A D +D G N E+ Y +     +  F +D D+G ++
Sbjct: 2983 FLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWIS 3042

Query: 2567 TQRPLQS--YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIRE 2624
                L S   + F +TV A D G PPL     + + V + N + P F +        I E
Sbjct: 3043 VASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT--IPE 3100

Query: 2625 EIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQ 2684
               + S V  V A D+D  +NG ++YS   ++GN +   F I+  +G++  A+ LD E  
Sbjct: 3101 SHSIGSIVRTVSARDRDAAMNGLIKYSI--SSGNEEG-IFAINSSTGILTLAKALDYELC 3157

Query: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRG 2744
              + + + A D G  V       + V + D++DN P+F+     S  Y   TV E++P G
Sbjct: 3158 QKHEMTISAIDGGW-VARTGYCSVTVNVIDVNDNSPVFL-----SDDY-FPTVLENAPSG 3210

Query: 2745 TLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIV 2803
            T V ++  A DAD G NA++ Y + + + +  F + P+ G +     LD E +  +   V
Sbjct: 3211 TTVIHLN-ATDADSGTNAVIAYTVQSSDSDL-FVIDPNTGVITTQGFLDFETKQSYHLTV 3268

Query: 2804 KASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGS 2863
            KA +           P  +  +  T   V + L+  N+  PRF    Y   ++  A  G+
Sbjct: 3269 KAFN----------VPDEERCSFAT---VNIQLKGTNEYVPRFVSKLYYFEISEAAPKGT 3315

Query: 2864 ELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
             + +V A D D+G +  V Y I      +     ++  GQ++  G +D
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIFGNSRKKGF-QINKKTGQIYVSGILD 3362



 Score = 1002 bits (2591), Expect = 0.0
 Identities = 878/2890 (30%), Positives = 1368/2890 (47%), Gaps = 202/2890 (6%)

Query: 41   LISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
            ++ E+  +G  V  + A  MD N  + + ++  +    FA+   TG +     +DRE +S
Sbjct: 801  VVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQS 860

Query: 100  EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
             + ++   S         VNI V D+NDN+P F     SV + EN   G  IF   A DP
Sbjct: 861  FYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDP 920

Query: 160  DLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
            D G  G VLYS  Q P   FAI+   G ++++  LD     +YQ+ + A+D    + LS+
Sbjct: 921  DEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAG-SYQIEILASDMGVPQ-LSS 978

Query: 219  LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
               L + + DV D  P+F  L Y   + E  P  +    + A D+D G    I YTI  G
Sbjct: 979  SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038

Query: 279  NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILV 338
            NT   F + +  G L +   LDRE       ++L V  +    DR     + T    +++
Sbjct: 1039 NTGDAFGI-FPDGQLYIKSELDRE---LQDRYVLMVVAS----DRAVEPLSATVNVTVIL 1090

Query: 339  IDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLNSMFEVYLVGNNSH 396
             D+NDN P FNS+ Y+    E  + G  +   +  VDKD   N  +   FE+       H
Sbjct: 1091 EDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-VSAVDKDFGPNGEVRYSFEMVQPDFELH 1149

Query: 397  HFIISPTSVQGKADIRIRVAIPLDYETVDR------YDFDLFA-NESVPDHV-GYAKVKI 448
                   ++ G+    I      D E++ R      + F + A ++ +P  +   A V +
Sbjct: 1150 -------AISGE----ITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198

Query: 449  TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRF 506
             + + NDN P F +  Y  ++ E+    T VL V A+D D G  G + Y     ++  +F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258

Query: 507  SLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKD 564
            ++D  +G + LI +LDYE    ++L I A D G     +T  + I++LD NDN P+F K 
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS 1318

Query: 565  AYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVS 624
                 + EN      +  + ATD DS  N  + YSI   +  G++   S+    G I ++
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTF---SISPNTGSIFLA 1375

Query: 625  RPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
            + LD+E  +  L  L + A D G PP +ST+ V I V D NDNPP+F     F S+VENI
Sbjct: 1376 KKLDFE--TQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENI 1433

Query: 685  MAGATVLFLNATDLDRSREYGQES--IIYSLEGSTQFRINARSGEITTTSLLDRETKSEY 742
              G +V+ + A D D     GQ S  II  +     F I+   G I T + +DRE  + +
Sbjct: 1434 PIGTSVISVTAHDPDADIN-GQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLF 1492

Query: 743  ILIVRAVDGGVG-HNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP---DSDVT 798
             L V+A D  V    ++  +  V I + D+NDN P +       N +   P     S +T
Sbjct: 1493 ELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQ----NALAADPSAVIGSVLT 1548

Query: 799  TVVAVDPDLGENGTLVYSI-QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIV 857
            T++A DPD G NG + Y I       + ++  +G +R   A++         ++L+  ++
Sbjct: 1549 TIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVP--------SQLIYNLI 1600

Query: 858  VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 917
            VS TD G    K+T+  T+ +  LD     P F    ++  + EG P G ++  + A   
Sbjct: 1601 VSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIGTNVISIEAAS- 1655

Query: 918  DEGLNG-----LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA-EYQLRVVASDAG 971
              G        +VS R         F I   +G++ T   LDRE+ A  Y + V A +  
Sbjct: 1656 PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKS 1715

Query: 972  TP-TKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
            T   ++  + + I + D+ND  P F   + +++V E++    +++ L   D D G NA +
Sbjct: 1716 TAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALV 1775

Query: 1031 SYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFV 1090
            +Y I  G  D  F +      +     LDRE  + Y L++ A D        +    + +
Sbjct: 1776 TYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG-----LQSSDMRINI 1829

Query: 1091 TVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNF 1150
            TV DVND+ P F +  Y   +PED   G  +  + ATD D G  G + Y +   +    F
Sbjct: 1830 TVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIF 1889

Query: 1151 RIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ 1210
             ++   G+     R LD E    ++L V A   D G   +++RV   + D+ND  P+F+ 
Sbjct: 1890 FLNPITGVFNL-TRLLDYEVQQYYILTVRA--EDGGGQFTTIRVYFNILDVNDNPPIFSL 1946

Query: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVN 1269
              YS   L E   +G++V+V   TD D G    + Y I SG   G+F +D++ G++  + 
Sbjct: 1947 NSYST-SLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLK 2004

Query: 1270 YLDYETKTSYMMNVSATDQAPPFNQGFCS---VYITLLNELDEAVQFSNASYEAAILENL 1326
             LD E+++ Y + V   D        F S   V I LL+  D    F +      I EN 
Sbjct: 2005 ALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENT 2063

Query: 1327 ALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
             + T + + QA   D+       +        K  F I  I G + + G +DRE+   YT
Sbjct: 2064 PIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--FSIGTIDGEVRLTGELDREEVSNYT 2121

Query: 1387 LTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWD 1445
            LTVVA D G P + S+ +V + VLD NDN+P F   +   V I E+   G  +  V A D
Sbjct: 2122 LTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFA-QALYKVEINENTLTGTDIIQVFAAD 2180

Query: 1446 PDAGSNGQVVFSLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGT 1504
             D G+NGQV + + +GN    F I    DS+ G + VA+PLDRE+   Y L V A+DRG+
Sbjct: 2181 GDEGTNGQVRYGIVNGNTNQEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGS 2236

Query: 1505 PPRKKDHILQVTILDINDNPPVIE-SPFGYNVSVNENVGG-GTAVVQVRATDRDIGINSV 1562
             PR     + + +LDIND  PV E SP  Y+V+V EN+G     ++QV A D D G NS 
Sbjct: 2237 TPRTDTSTVSIVLLDINDFVPVFELSP--YSVNVPENLGTLPRTILQVVARDDDRGSNSK 2294

Query: 1563 LSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
            LSY +  GN+D AF +   SGE+    +  DRE +  + L+ T  D G+P L+ T  + V
Sbjct: 2295 LSYVLFGGNEDNAFTLSA-SGELGVTQSL-DRETKERFVLMITATDSGSPALTGTGTINV 2352

Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT 1682
             + D NDN P F    Y   + E   T  T ++ + A D D   N  +   I+ GN  + 
Sbjct: 2353 IVDDVNDNVPTFASKAYFTTIPEDAPT-GTDVLLVNASDADASKNAVIR--IIGGN--SQ 2407

Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
            F I+   G I  +  LD E +   YTL+V  +D        L+S+T+VLV V D+NDN P
Sbjct: 2408 FTINPSTGQIITSALLDRE-TKDNYTLVVVCSDAGS--PEPLSSSTSVLVTVTDVNDNPP 2464

Query: 1743 TFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLR 1802
             F          +   PG  V+     D D GPN ++ YS+  G    +F I P+ G + 
Sbjct: 2465 RFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIM 2523

Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
                +    E       ++  +D G  P + +  V +R ++  D  P +          E
Sbjct: 2524 AAGPLNGASEV----TFSVHVKDGGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPE 2578

Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
            N PVSS V  +  S         +++ I +GN    F I+  TG V++++PLD E+I +Y
Sbjct: 2579 NQPVSSLVTTITGSSLRG---EPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKY 2635

Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
             + I  +D    P  +   Y+ L I + D NDN P+F +  + +E++EN      LTV  
Sbjct: 2636 VVWIEARDGGFPPFSS---YEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVS- 2691

Query: 1983 GPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
                A+D D      + Y+++ G     F IN +TG   +RS   +DRE  S  +L +  
Sbjct: 2692 ----AMDKDSGPNGQLDYEIVNGNMENSFSINHATG--EIRSVRPLDREKVSHYVLTIKS 2745

Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
              +     +++  ++I ILD+NDN P FS    + H+ EN P G++V +VT +DED G+N
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGIN 2804

Query: 2102 GELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
                Y I   A   F I+  TG I +    ++RE+ + YR+ V A D G    +    VT
Sbjct: 2805 AISRYSI-MDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSAHDSGWTVSTD---VT 2859

Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDD 2219
            I + DIND+ P F      +   E  E G+ +  + A D D   N ++ Y I        
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI-------- 2911

Query: 2220 TDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYE-VTL---SVIDNASDLPERSVSVP 2275
                  +Q + F +N  TG +  K  +  + V  +  V +   S I  +SD  + S+ + 
Sbjct: 2912 -----KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSL-IS 2965

Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDP-DKGLNGLVTYT 2334
               +T+N++D NDN PQF     + Y   + +    GT LI V A+D  D GLN  V Y 
Sbjct: 2966 ETTVTINIVDSNDNAPQFLK---SKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYF 3022

Query: 2335 LLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
            + +    G  +L++ +    +A+  +     ++   TV A D G+PP +++  V++ + +
Sbjct: 3023 ISNDNHLGKFKLDNDTGWISVASSLISDLNQNFF-ITVTAKDKGNPPLSSQATVHITVTE 3081

Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG--ESKFAINP 2452
             N + P F Q      + E   +G+I+ TV+A D D+    LI+YS+  G  E  FAIN 
Sbjct: 3082 ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINS 3141

Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
            +TG + +  +LD E    + +T  A D  G VA   R     V + V+DVND  P F   
Sbjct: 3142 STGILTLAKALDYELCQKHEMTISAIDG-GWVA---RTGYCSVTVNVIDVNDNSPVFLSD 3197

Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL- 2571
             +  +V EN P+GT+VI + ATD D G N  + Y+++    + F +D ++G++TTQ  L 
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLD 3257

Query: 2572 -QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
             ++ + + LTV A +  +        + +++   N+  P FV         I E  P  +
Sbjct: 3258 FETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFV--SKLYYFEISEAAPKGT 3315

Query: 2631 NVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLI 2690
             V EV+A+D+D G +G V Y      GN   + F I+  +G I  +  LDRE +   SL 
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIF---GNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372

Query: 2691 LVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV 2750
            ++A + G  +    +  + V +  +D N+     PP  +     + + E  P GT V  V
Sbjct: 3373 VLAKNFGS-IRGADIDEVTVNVTVLDAND-----PPIFTLNIYSVQISEGVPIGTHVTFV 3426

Query: 2751 TGAVDADEGPN-AIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSN 2808
            + A D+D  P+ +   YFI +GNE   F + P  G + V  +LDRE   I++  V A   
Sbjct: 3427 S-AFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD- 3484

Query: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2868
             S TP    S +L            V LEDIND  P  T +E    V  + + G+ ++ +
Sbjct: 3485 -SGTPSATGSASL-----------LVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTL 3530

Query: 2869 LALDADIGNN 2878
             + D D+  N
Sbjct: 3531 QSTDPDLPPN 3540



 Score =  976 bits (2522), Expect = 0.0
 Identities = 873/2919 (29%), Positives = 1373/2919 (47%), Gaps = 229/2919 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            + ED  VGSSV Q+ A D D   N  + + +  E     F ++P+TG++ +R+PLD E +
Sbjct: 259  VPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEAR 316

Query: 99   SEFTVEFSVSDHQGV--ITRKVN--IQVGDVNDNAPT--FHNQPYSVR---IPENTPVGT 149
             ++++     D +GV  +T +    IQ+ DVNDN P   F   P + R   + EN  VGT
Sbjct: 317  RQYSLTVQAMD-RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGT 375

Query: 150  PIFIVNATDPDLGAGG---SVLYSFQPPSQFFAIDSAR----GIVTVIRELDYETTQAYQ 202
             + ++  TD D  A     SV        + F + S++     ++ V   LD E   +Y 
Sbjct: 376  VVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYN 435

Query: 203  LTVNATDQDKTRP------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
            LTV+ +D     P       S++A+L I + D+ D  P+F    Y  N+ E +PPG+ V 
Sbjct: 436  LTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVS 495

Query: 257  IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL--NGLLDRENPLYSHGFILTV 314
             I+A D D G    + Y+IVSGN    F +   SG++T   +G LDRE    +   +L +
Sbjct: 496  GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE---LASQIVLNI 552

Query: 315  KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQV 373
               +       S A +  T    ++D+ND  P F+  E Y V++ E A  G  L L ++ 
Sbjct: 553  SARDQGVHPKVSYAQLVVT----LLDVNDEKPVFSQPEGYDVSVVENAPTGTEL-LMLRA 607

Query: 374  VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
             D D        F +     +   F + P S       R+     LD E    Y   + A
Sbjct: 608  TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG------RLSTISSLDREEQAFYSLLVLA 661

Query: 434  NE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492
             +   P     A++ ++L++ NDN P+F    Y   + EN   G+ + TV ATD D GT 
Sbjct: 662  TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721

Query: 493  GEVSYFFS-DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR--VRI 549
            G V Y  S  D  RF ++  +G+I     LD E    + L I+A DGG  ++  +  V I
Sbjct: 722  GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
             VLD  DN P F + AY   + EN      +  + A+  D   N+ I+Y I +    G +
Sbjct: 782  TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMF 839

Query: 610  FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
               ++ +  G ++ +  +D E+ S    +  +  + +G      T+ V I V D NDN P
Sbjct: 840  ---AINQVTGQLTTANVIDREEQS----FYQLKVVASGGTVTGDTM-VNITVKDLNDNSP 891

Query: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGE 727
             F +    V+VVEN  AG ++    A D D   E     ++YSL+ + +  F IN ++G 
Sbjct: 892  HFLQAIESVNVVENWQAGHSIFQAKAVDPD---EGVNGMVLYSLKQNPKNLFAINEKNGT 948

Query: 728  ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
            I+    LD    S Y + + A D GV     + I TV +   D+NDN P +    Y + L
Sbjct: 949  ISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVH--DVNDNSPVFDQLSYEVTL 1005

Query: 788  VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
             E  P +S    V A D D G NG + Y+I   N   +            + LDRE  D 
Sbjct: 1006 SESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDR 1065

Query: 848  HEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGV 907
            +       ++V  +D    PL AT + TV   L D+NDN P F +  +     E   AG 
Sbjct: 1066 Y------VLMVVASDRAVEPLSATVNVTVI--LEDVNDNRPLFNSTNYTFYFEEEQRAGS 1117

Query: 908  SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI------AEY 961
             + +V A+D D G NG V Y   +  P  DF +++ SG +  T + DRE +      A +
Sbjct: 1118 FVGKVSAVDKDFGPNGEVRYSFEMVQP--DFELHAISGEITNTHQFDRESLMRRRGTAVF 1175

Query: 962  QLRVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
               V+A+D G P      +T+ +++ D+ND  P F    Y  ++SE      +V+ ++ +
Sbjct: 1176 SFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235

Query: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080
            D D G N  + Y I  GN + +F++      V  +  LD E T AY L+++A+D+G +  
Sbjct: 1236 DVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPL 1295

Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140
                T T+ + +LD NDN P F +S+    V E++  G  +  + ATD+D G+   ++Y 
Sbjct: 1296 --NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYS 1353

Query: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
            I   N+   F I  + G +    + LD E  S + L + A +    P  S++ V+++V D
Sbjct: 1354 ITGTNNHGTFSISPNTGSIFLA-KKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412

Query: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE--GKFEI 1258
             ND  P F      +  + E   IGTSVI V A D D+   G ++Y I+        F I
Sbjct: 1413 FNDNPPSFPPGDIFK-SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471

Query: 1259 DESTGLIITVNYLDYETKTSYMMNVSATDQAPPF-NQGFCSVYITLL-NELDEAVQFSNA 1316
            DE  G I T   +D E    + + V A DQA P   + +    +T+L  +L++ V    +
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531

Query: 1317 SYEAAILENLALGTEIVRVQAYSIDN--LNQITYR-FNAYTSTQAKALFKIDAITGVITV 1373
                A   +  +G+ +  + A   D     +I Y   N  T T     F +D  +G + V
Sbjct: 1532 QNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDT-----FIVDRYSGDLRV 1586

Query: 1374 -QGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI-PED 1431
               LV  +    Y L V A D GP+   +      +L   D      FT    ++I  E 
Sbjct: 1587 ASALVPSQL--IYNLIVSATDLGPERRKSTTELTIILQGLDGPV---FTQPKYITILKEG 1641

Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNI--AGAFEIVTTNDSIGEVFVARPLDREE 1489
             P+G  V +++A  P  GS   V + + S          + T     G +  A  LDRE+
Sbjct: 1642 EPIGTNVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQ 1700

Query: 1490 -LDHYILQVVASDRGTP-PRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
                Y++ V A ++ T  PR +   +++T+ DINDNPPV  +    +++V EN+G G+ +
Sbjct: 1701 GACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM-LDLTVEENIGDGSKI 1759

Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE-IATRPAPPDRERQSFYHLVATV 1606
            +Q+ A D D G N++++Y I  G  D +FR+D  SG+ IATR    DRER+S Y L+   
Sbjct: 1760 MQLTAMDADEGANALVTYTIISGADD-SFRIDPESGDLIATRRL--DRERRSKYSLLVRA 1816

Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEG 1665
            +D      S+   + +T+ D ND+ P F +P Y   + E  DT+  SL+  I A D D G
Sbjct: 1817 DD---GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPE--DTIPGSLVAAILATDDDSG 1871

Query: 1666 PNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLT 1725
             NG +TY +   +    F ++   GV    + LDYE+    Y L V A D          
Sbjct: 1872 VNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQ-YYILTVRAED-----GGGQF 1925

Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMD 1785
            +T  V  N+ D+NDN P F  +      +     G  V  F   D D G N Q+ YSI  
Sbjct: 1926 TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS 1985

Query: 1786 GDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLS---STMLVGIRVL 1842
            GD LG+F +    GVL+V K   LDRE+ +FYNL +   D    P S   ST  V I +L
Sbjct: 1986 GDSLGQFTVDK-NGVLKVLK--ALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL 2042

Query: 1843 DINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI--TAGNRERAFF 1900
            D+NDN P  L+ P    I EN+P+ + V    A+D DSG N+ + + +    GN+   F 
Sbjct: 2043 DVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK---FS 2098

Query: 1901 INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFT 1960
            I    G V +   LDRE +  Y LT+   D  +    +  +   +++ + D NDN+P+F 
Sbjct: 2099 IGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTE---VVVMVLDINDNNPIFA 2155

Query: 1961 KSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVV 2019
            ++ Y+ E+ EN+  GT +      + A D D+     V Y ++ G  +  F I+S TG +
Sbjct: 2156 QALYKVEINENTLTGTDII----QVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAI 2211

Query: 2020 TVRSGVIIDREAFSPPILELLLLAEDIGLL--NSTAHLLITILDDNDNRPTFSPATLTVH 2077
            TV     +DRE    P   L + A D G      T+ + I +LD ND  P F  +  +V+
Sbjct: 2212 TVAKP--LDRE--KTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVN 2267

Query: 2078 LLENCPP-GFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREE 2136
            + EN      ++LQV A D+D G N +L Y +  G +D       +G + V   ++DRE 
Sbjct: 2268 VPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGV-TQSLDRET 2326

Query: 2137 QESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANI 2196
            +E + L + ATD G+  L+GT  + +++DD+ND+ P F +     ++ E A  GT +  +
Sbjct: 2327 KERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLV 2386

Query: 2197 TAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEV 2256
             A D D +      I+G                 F +N +TG ++  + ++RE    Y +
Sbjct: 2387 NASDADASKNAVIRIIG-------------GNSQFTINPSTGQIITSALLDRETKDNYTL 2433

Query: 2257 TLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
             +   D  S  P  S    +  + V V DVNDN P+F+      Y+  I     PG+ + 
Sbjct: 2434 VVVCSDAGSPEPLSS----STSVLVTVTDVNDNPPRFQHHP---YVTHIPSPTLPGSFVF 2486

Query: 2317 AVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASD 2376
            AV   D D G N  + Y+L       +    D   G ++A   ++      + F+V   D
Sbjct: 2487 AVTVTDADIGPNSELHYSLSGRNSEKF--HIDPLRGAIMAAGPLN--GASEVTFSVHVKD 2542

Query: 2377 NGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF---EDVPVGTIILTVTATD--ADS 2431
             GS P+     V +  V    N   F +   +E  F   E+ PV +++ T+T +    + 
Sbjct: 2543 GGSFPKTDSTTVTVRFV----NKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEP 2598

Query: 2432 GNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRREN 2491
             ++ +   +LG   + F I+  TG + +   LD EK   Y++   A+D      S+    
Sbjct: 2599 MSYYIASGNLG---NTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYE-- 2653

Query: 2492 SVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2551
              ++ I VLDVND  P F +  F + + EN  +   ++T+ A D+D GPNG+L Y +   
Sbjct: 2654 --KLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNG 2710

Query: 2552 GVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
             +E +F ++  +G + + RPL  +    + LT+ ++D G P    +  +++ ++D NDN 
Sbjct: 2711 NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNA 2770

Query: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
            P F +  +    H+ E  PL   V  V  +D+D G+N   RYS +  +       F I+P
Sbjct: 2771 PRFSQIFSA---HVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP-----FTINP 2822

Query: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
             +G I  ++ L+RE    Y + + A D G  V  +    + + + DI+DN P F R    
Sbjct: 2823 STGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTD----VTIFVTDINDNAPRFSRTS-- 2876

Query: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVL 2788
                  L  PE +  G+ V  V  A D DEG N  V+YFI + +E    +    G +   
Sbjct: 2877 ----YYLDCPELTEIGSKVTQVF-ATDPDEGSNGQVFYFIKSQSEYFRIN-ATTGEIFNK 2930

Query: 2789 RDLDREREAIFSFI-VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFT 2847
            + L  +    FS + +   S    +  RG      L+++ T   V + + D ND  P+F 
Sbjct: 2931 QILKYQNVTGFSNVNINRHSFIVTSSDRGKP---SLISETT---VTINIVDSNDNAPQFL 2984

Query: 2848 KAEYTAGVATDAKVGSELIQVLAL-DADIGNNSLVFYSI 2885
            K++Y   V  + KVG++LI+V A+ D D G NS V Y I
Sbjct: 2985 KSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI 3023



 Score =  970 bits (2507), Expect = 0.0
 Identities = 855/2630 (32%), Positives = 1249/2630 (47%), Gaps = 209/2630 (7%)

Query: 245  IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP 304
            + E  PPGT V  I        RP   G+T     ++++FA++  +G L     +DRE+ 
Sbjct: 51   VLEEQPPGTLVGTIQT------RP---GFTYRLSESHALFAINSSTGALYTTSTIDRES- 100

Query: 305  LYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVG 364
                     +    +N     S  T  T   +LV D+NDNAP F      V   E +  G
Sbjct: 101  ---------LPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSG 151

Query: 365  FALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT---SVQGKADIRIRVAIPLDY 421
              + L         + G++      + GN +  F +  T   S +G A + +     LD 
Sbjct: 152  RQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEG-AFLHLVSKGGLDR 210

Query: 422  ETVDRYDFDL-FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
            E   +Y   +   ++  P   GY +V +T+ + NDN P+F    Y   + E+  VG+SVL
Sbjct: 211  EVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL 270

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540
             V A D D GT  ++ Y   D+   F +D +TGLI +   LD+E  ++++LT+ A D G 
Sbjct: 271  QVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGV 330

Query: 541  EETTGRVR--INVLDVNDNVPT-----FQKDAYVGALRENEPSVTQLVRLRATDEDSP-P 592
               TGR    I +LDVNDN P      F   +   ++ EN    T +  L  TD DSP  
Sbjct: 331  PSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA 390

Query: 593  NNQITYSIVSASAFGSYFDI--SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMD-AGNP 649
            N  I+  I+  +    +F++  S      +I V+  LD E+I +    LTV   D  G P
Sbjct: 391  NGNISVQILGGNE-QRHFEVQSSKVPNLSLIKVASALDRERIPS--YNLTVSVSDNYGAP 447

Query: 650  P------LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE 703
            P       +S   + I V D ND+PP FS+  Y V++ E    G+ V  ++ATD D    
Sbjct: 448  PGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLN 507

Query: 704  YGQESIIYSLEGSTQFRINARSGEITTTSL--LDRETKSEYILIVRAVDGGVGHNQKTGI 761
                  I S  G   F I+  SG +TT S   LDRE  S+ +L + A D GV  + K   
Sbjct: 508  ANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGV--HPKVSY 565

Query: 762  ATVNITLLDINDNHPTWKDAP-YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
            A + +TLLD+ND  P +     Y +++VE  P  +++  + A D DLG+NGT+ +S+Q  
Sbjct: 566  AQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEA 625

Query: 819  -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
                + + L+  +G++ +T + LDRE       +    ++V  TD G PP   +S A + 
Sbjct: 626  ETDRRSFRLDPVSGRL-STISSLDREE------QAFYSLLVLATDLGSPP--QSSMARIN 676

Query: 878  VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD 937
            V+LLD+NDN P F  + + A + E  P G  I  V A D D G NG V Y +  G  R  
Sbjct: 677  VSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAG-DRSR 735

Query: 938  FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFP 997
            F +N+ SGV+ T   LDRE    YQL++VA+D G     + + +TI VLD  D  P F  
Sbjct: 736  FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQ 795

Query: 998  AVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVG 1057
              Y+  V E+V   + V  ++ +  D  LN+ +SY IT G+  G F++      + T   
Sbjct: 796  VAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTTANV 853

Query: 1058 LDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPE 1117
            +DRE  + Y L + A      G   TG   V +TV D+NDN P FLQ+    +V E+   
Sbjct: 854  IDREEQSFYQLKVVA-----SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQA 908

Query: 1118 GHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNSSHVL 1176
            GHSI Q KA D DEG  G V Y  L  N  N F I+  NG + + G  PLD    S  + 
Sbjct: 909  GHSIFQAKAVDPDEGVNGMVLYS-LKQNPKNLFAINEKNGTISLLG--PLDVHAGSYQIE 965

Query: 1177 IVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDR 1236
            I+ A +  +  + SSV + VYV D+ND +PVF Q  Y  + L E+  + +    VQA+D+
Sbjct: 966  IL-ASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSY-EVTLSESEPVNSRFFKVQASDK 1023

Query: 1237 DSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
            DSG  G + Y I  G  G        G +   + LD E +  Y++ V A+D+A       
Sbjct: 1024 DSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSAT 1083

Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYT 1354
             +V + L +  D    F++ +Y     E    G+ + +V A   D     ++ Y F    
Sbjct: 1084 VNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFE--- 1140

Query: 1355 STQAKALFKIDAITGVITVQGLVDREK------GDFYTLTVVADDGG----PKVDSTVKV 1404
                +  F++ AI+G IT     DRE          ++ TV+A D G     K  +TV V
Sbjct: 1141 --MVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198

Query: 1405 YITVLDENDNSPRF--DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGN 1462
            Y+   D NDN+P+F  DF      +I E      +V  V A D D G+NG + +S+  GN
Sbjct: 1199 YMK--DINDNAPKFLKDFYQ---ATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253

Query: 1463 IAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
                F I +T+   G+V +   LD E    Y L + A D GT P      L + ILD ND
Sbjct: 1254 EERQFAIDSTS---GQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDEND 1310

Query: 1523 NPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRIS 1582
            N P       + V V EN+  G  V  V ATD D G N+ L Y IT  N    F +   +
Sbjct: 1311 NTPSFPKSTLF-VDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNT 1369

Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH-YEV 1641
            G I       D E QS Y L  T +D+G P  S+T  V + + D NDN P F     ++ 
Sbjct: 1370 GSIFL-AKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKS 1428

Query: 1642 LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAG-NIVNTFRIDRHMGVITAAKELDY 1700
            +++  P  + TS+I++ A D D   NG ++Y I+      N F ID   G I    E+D 
Sbjct: 1429 IVENIP--IGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDR 1486

Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPG 1760
            E ++  + L V A DQ   +  R  +   V + V D+NDNVP F        +      G
Sbjct: 1487 EFAN-LFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAAD-PSAVIG 1544

Query: 1761 PRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLT 1820
              + T +A D D G NG++EY I++GD    F++    G LRV   +   +     YNL 
Sbjct: 1545 SVLTTIMAADPDEGANGEIEYEIINGD-TDTFIVDRYSGDLRVASALVPSQ---LIYNLI 1600

Query: 1821 ICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI-SENSPVSSFVAHVLASDAD 1879
            + A D G     ST  + I +  +   D  +   P  ITI  E  P+ + V  + A+ + 
Sbjct: 1601 VSATDLGPERRKSTTELTIILQGL---DGPVFTQPKYITILKEGEPIGTNVISIEAA-SP 1656

Query: 1880 SGCNARLTFNITAGNRE-----RAFFINATTGIVTVNRPLDRERIPEYKL--TISVKDNP 1932
             G  A + + I +   E     R F I   TGI+     LDRE+     L    +++ + 
Sbjct: 1657 RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKST 1716

Query: 1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ 1992
              PR  R + +   I L D NDN P+F        V EN   G+ +  L     A+DAD+
Sbjct: 1717 AFPRTQRAEVE---ITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT----AMDADE 1769

Query: 1993 DIYAVVTYQLLGAQSGLFDINSSTG--VVTVRSGVIIDREAFSPPILELLLLAEDIGLLN 2050
               A+VTY ++      F I+  +G  + T R    +DRE  S     LL+ A+D GL +
Sbjct: 1770 GANALVTYTIISGADDSFRIDPESGDLIATRR----LDRERRSK--YSLLVRADD-GLQS 1822

Query: 2051 STAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA 2110
            S   + IT+ D ND+ P FS    +  + E+  PG  V  + ATD+DSG+NGE+ Y +  
Sbjct: 1823 SDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE 1882

Query: 2111 GAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
              +D  F ++ +TGV  +    +D E Q+ Y LTV A D G    +      IL  D+ND
Sbjct: 1883 DDEDGIFFLNPITGVFNL-TRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNIL--DVND 1939

Query: 2170 SRPEFLNPIQTVSVLESAEPGT--VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQ 2227
            + P F     + S++E+   G+  ++ N+T  D  +N +L Y I              + 
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS-----------GDS 1988

Query: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS--VPNAKLTVNVLD 2285
               F V+ N G + V   ++RE  + Y + + V     DLP+   S     A++++ +LD
Sbjct: 1989 LGQFTVDKN-GVLKVLKALDRESQSFYNLVVQV----HDLPQIPASRFTSTAQVSIILLD 2043

Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
            VNDN P F    +TY    I E     T +    A DPD G N  + YTLL+  P G   
Sbjct: 2044 VNDNPPTFLSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLN--PLGNKF 2097

Query: 2346 LEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQP 2405
               +  G+V     +D EEV     TV A+D G P  ++   V + ++DINDNNPIF Q 
Sbjct: 2098 SIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQA 2157

Query: 2406 SYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSL 2463
             Y+  + E+   GT I+ V A D D G    + Y +  G+   +F I+  TG I V   L
Sbjct: 2158 LYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPL 2217

Query: 2464 DREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEP 2523
            DREK   Y LT  A D      S  R ++  V I +LD+ND  P F    +S +V EN  
Sbjct: 2218 DREKTPTYHLTVQATDR----GSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPEN-- 2271

Query: 2524 AGT---SVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGL-VTTQRPLQSYEKFS 2578
             GT   +++ ++A D D G N +L+Y L G   + AF +     L VT     ++ E+F 
Sbjct: 2272 LGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFV 2331

Query: 2579 LTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
            L + ATD G P L GT  + V V DVNDN P F      T   I E+ P  ++V  V A+
Sbjct: 2332 LMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTT--IPEDAPTGTDVLLVNAS 2389

Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
            D D   N  +R       GN     F I+P +G I T+  LDRE++  Y+L++V SD G 
Sbjct: 2390 DADASKNAVIRI----IGGNSQ---FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGS 2442

Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV---D 2755
            P P  +   + V + D++DN P F   P             H P  TL G+   AV   D
Sbjct: 2443 PEPLSSSTSVLVTVTDVNDNPPRFQHHP----------YVTHIPSPTLPGSFVFAVTVTD 2492

Query: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVK 2804
            AD GPN+ ++Y ++  N EK FH+ P  G ++    L+   E  FS  VK
Sbjct: 2493 ADIGPNSELHYSLSGRNSEK-FHIDPLRGAIMAAGPLNGASEVTFSVHVK 2541



 Score =  969 bits (2505), Expect = 0.0
 Identities = 901/2899 (31%), Positives = 1335/2899 (46%), Gaps = 222/2899 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLVFGVSG-------EEASRFFAVEPDTGVVWLRQPLD 94
            + E+   G S+ Q  A D D      GV+G       +     FA+    G + L  PLD
Sbjct: 902  VVENWQAGHSIFQAKAVDPDE-----GVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLD 956

Query: 95   RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
                S + +E   SD  GV        + + V DVNDN+P F    Y V + E+ PV + 
Sbjct: 957  VHAGS-YQIEILASD-MGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSR 1014

Query: 151  IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDS-ARGIVTVIRELDYETTQAYQLTVNATD 209
             F V A+D D GA G + Y+    +   A      G + +  ELD E    Y L V A+D
Sbjct: 1015 FFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASD 1074

Query: 210  QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
            +    PLS   N+ +I+ DV D  P+F +  Y+    E    G+ V  ++A+D+D G   
Sbjct: 1075 R-AVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNG 1133

Query: 270  GIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHG---FILTVKGTELNDDRTPS 326
             + Y+      +  F L  ISG +T     DRE+ +   G   F  TV  T   D   P 
Sbjct: 1134 EVRYSFEMVQPD--FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIAT---DQGIPQ 1188

Query: 327  DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
                  T ++ + DINDNAP+F    Y   I+E A     L   ++V   D + G N + 
Sbjct: 1189 PLKDQATVHVYMKDINDNAPKFLKDFYQATISESAA---NLTQVLRVSASDVDEGNNGLI 1245

Query: 387  EVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES--VPDHVGY 443
               ++ GN    F I  TS Q      + +   LDYE    Y   + A +S  +P +   
Sbjct: 1246 HYSIIKGNEERQFAIDSTSGQ------VTLIGKLDYEATPAYSLVIQAVDSGTIPLN-ST 1298

Query: 444  AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS--D 501
              + I +++ENDN P F +    + + EN+ +G  V +V ATD+D+G   ++ Y  +  +
Sbjct: 1299 CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTN 1358

Query: 502  DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVP 559
            +   FS+  +TG I L  +LD+E    + L I A+D G     +T  V I+V D NDN P
Sbjct: 1359 NHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPP 1418

Query: 560  TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
            +F       ++ EN P  T ++ + A D D+  N Q++Y+I+     G++F I   E  G
Sbjct: 1419 SFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTID--EVKG 1476

Query: 620  VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVP---VTIEVFDENDNPPTF-SKPA 675
             I  +  +D E  +  L  LTV A D   P          VTI V D NDN P F S+ A
Sbjct: 1477 TIYTNAEIDREFAN--LFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNA 1534

Query: 676  YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLD 735
              ++   + + G+ +  + A D D       E  I + +  T F ++  SG++   S L 
Sbjct: 1535 --LAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALV 1591

Query: 736  RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDS 795
              ++  Y LIV A D G    + T   T+ +  LD     P +    Y   L E  P  +
Sbjct: 1592 -PSQLIYNLIVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIGT 1646

Query: 796  DVTTVVAVDPDLGENGTLVYSI------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHE 849
            +V ++ A  P   E     Y +      +   + +++   TG I+T  A+LDRE      
Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTA-AILDREQG---- 1701

Query: 850  AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
            A L    V ++      P   T  A V + L D+NDN P F        V E I  G  I
Sbjct: 1702 ACLYLVDVYAIEKSTAFP--RTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKI 1759

Query: 910  YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
             Q+ A+D DEG N LV+Y +  G     F I+  SG ++ T  LDRER ++Y L V A D
Sbjct: 1760 MQLTAMDADEGANALVTYTIISGADD-SFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818

Query: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
                 +SS   + I V DVND TP F   VY+  + ED      V  +  TD+D G+N E
Sbjct: 1819 G---LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGE 1875

Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
            ++Y +   + DG F +     V      LD E    Y+L + A D G        T  V+
Sbjct: 1876 ITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG----QFTTIRVY 1931

Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN 1149
              +LDVNDN PIF  +SY  S+ E++P G ++L    TDAD+G   ++ Y I  G+    
Sbjct: 1932 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ 1991

Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPM-----RSSVRVIVYVEDINDE 1204
            F +   NG+L +  + LDRE  S + L+V+   HDL  +      S+ +V + + D+ND 
Sbjct: 1992 FTVD-KNGVL-KVLKALDRESQSFYNLVVQV--HDLPQIPASRFTSTAQVSIILLDVNDN 2047

Query: 1205 APVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGL 1264
             P F   + + +   E   I T V   QATD DSG    + Y +L+    KF I    G 
Sbjct: 2048 PPTFLSPKLTYIP--ENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE 2105

Query: 1265 IITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1324
            +     LD E  ++Y + V ATD+  P       V + +L+  D    F+ A Y+  I E
Sbjct: 2106 VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINE 2165

Query: 1325 NLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDF 1384
            N   GT+I++V A   D       R+        +  F+ID++TG ITV   +DREK   
Sbjct: 2166 NTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE-FRIDSVTGAITVAKPLDREKTPT 2224

Query: 1385 YTLTVVADDGG--PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR-VATV 1441
            Y LTV A D G  P+ D++  V I +LD ND  P F+  S  +V++PE+     R +  V
Sbjct: 2225 YHLTVQATDRGSTPRTDTST-VSIVLLDINDFVPVFEL-SPYSVNVPENLGTLPRTILQV 2282

Query: 1442 KAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASD 1501
             A D D GSN ++ + L  GN   AF    T  + GE+ V + LDRE  + ++L + A+D
Sbjct: 2283 VARDDDRGSNSKLSYVLFGGNEDNAF----TLSASGELGVTQSLDRETKERFVLMITATD 2338

Query: 1502 RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINS 1561
             G+P       + V + D+NDN P   S   Y  ++ E+   GT V+ V A+D D   N+
Sbjct: 2339 SGSPALTGTGTINVIVDDVNDNVPTFASK-AYFTTIPEDAPTGTDVLLVNASDADASKNA 2397

Query: 1562 VLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT-LSATTHV 1620
            V+   I  GN    F ++  +G+I T  A  DRE +  Y LV    D G+P  LS++T V
Sbjct: 2398 VIR--IIGGNSQ--FTINPSTGQIITS-ALLDRETKDNYTLVVVCSDAGSPEPLSSSTSV 2452

Query: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680
             VT+ D NDN P FQ   Y   +   P    + +  +   D D GPN  + Y++ +G   
Sbjct: 2453 LVTVTDVNDNPPRFQHHPYVTHIPS-PTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNS 2510

Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
              F ID   G I AA  L+        T  V   D         T+ T   VN  D    
Sbjct: 2511 EKFHIDPLRGAIMAAGPLN---GASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKAD---- 2563

Query: 1741 VPTFP--RDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVE 1798
               FP  R  E  F   E QP   + T +      G    + Y I  G+    F I  + 
Sbjct: 2564 ---FPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGE--PMSYYIASGNLGNTFQIDQLT 2618

Query: 1799 GVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNI 1858
            G + + +   LD E I  Y + I ARD G PP SS   + I VLD+NDN P+    P   
Sbjct: 2619 GQVSISQP--LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFIS 2676

Query: 1859 TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER 1918
             I EN      +  V A D DSG N +L + I  GN E +F IN  TG +   RPLDRE+
Sbjct: 2677 EILENLSPRKILT-VSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREK 2735

Query: 1919 IPEYKLTI--SVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
            +  Y LTI  S K +P      +     ++I + DENDN P F++  + A V ENSP G 
Sbjct: 2736 VSHYVLTIKSSDKGSPSQSTSVK-----VMINILDENDNAPRFSQ-IFSAHVPENSPLGY 2789

Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPI 2036
             +T     +   D D  I A+  Y ++ A S  F IN STG + +     ++RE      
Sbjct: 2790 TVT----RVTTSDEDIGINAISRYSIMDA-SLPFTINPSTGDIVISRP--LNRE--DTDR 2840

Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
              + + A D G   ST  + I + D NDN P FS  +  +   E    G  V QV ATD 
Sbjct: 2841 YRIRVSAHDSGWTVST-DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDP 2899

Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTG------VIRVGNAT-IDREEQESYRLTVVATDR 2149
            D G NG++ Y I++ ++  F I+  TG      +++  N T         +   V ++DR
Sbjct: 2900 DEGSNGQVFYFIKSQSE-YFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR 2958

Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD---LNPK 2206
            G   L     VTI I D ND+ P+FL       V ++ + GT +  +TAID     LN +
Sbjct: 2959 GKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSE 3018

Query: 2207 LEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASD 2266
            +EY I              N    F ++ +TG + V S +  +L   + +T++  D  + 
Sbjct: 3019 VEYFISN-----------DNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGN- 3066

Query: 2267 LPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKG 2326
             P  S     A + + V + N +TP+F     ++    I E  + G+ +  V+A D D  
Sbjct: 3067 -PPLS---SQATVHITVTEENYHTPEFSQ---SHMSATIPESHSIGSIVRTVSARDRDAA 3119

Query: 2327 LNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEI 2386
            +NGL+ Y++      G   + +SS G +   + +DYE       T+ A D G   R    
Sbjct: 3120 MNGLIKYSISSGNEEGIFAI-NSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYC 3178

Query: 2387 PVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES 2446
             V + ++D+NDN+P+F    Y   V E+ P GT ++ + ATDADSG  A+I Y++   +S
Sbjct: 3179 SVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS 3238

Query: 2447 K-FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
              F I+P TG I     LD E K  Y LT  A + P +     R +   V IQ+   N+ 
Sbjct: 3239 DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE----ERCSFATVNIQLKGTNEY 3294

Query: 2506 RPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGL 2564
             P+F    +   + E  P GT V  + A+D+D G +GE+ Y + G    + F ++  +G 
Sbjct: 3295 VPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQ 3354

Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTM----LLVEVIDVNDNRPVFVRPPNGT 2618
            +     L  +  E+ SL V+A + G   + G  +    + V V+D ND  P+F    N  
Sbjct: 3355 IYVSGILDREKEERVSLKVLAKNFGS--IRGADIDEVTVNVTVLDANDP-PIFTL--NIY 3409

Query: 2619 ILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             + I E +P+ ++V  V A D D  +    R+S+   +GN +  F I +P +G I     
Sbjct: 3410 SVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSI-NPQTGQITVTAE 3467

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            LDRE+  +Y+L ++A D G P    +   L V LEDI+DN P+     +G        V 
Sbjct: 3468 LDRETLPIYNLSVLAVDSGTPSATGSAS-LLVTLEDINDNGPMLT-VSEGE-------VM 3518

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNA--IVYYFIAAGNEEKNFHLQPDGCLLVLRDLDRERE 2796
            E+   GTLV  +  + D D  PN     YY ++ G     F L   G L   R++DRE+ 
Sbjct: 3519 ENKRPGTLVMTLQ-STDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ- 3576

Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
             I  F +   +  S  P    + T           V + + D ND P +    E      
Sbjct: 3577 -IADFYLSVVTKDSGVPQMSSTGT-----------VHITVIDQNDNPSQSRTVEIFVNYY 3624

Query: 2857 TDAKVGSELIQVLALDADI 2875
             +   G  L  V   D D+
Sbjct: 3625 GNLFPGGILGSVKPQDPDV 3643



 Score =  927 bits (2397), Expect = 0.0
 Identities = 780/2504 (31%), Positives = 1211/2504 (48%), Gaps = 185/2504 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            + E+  +G  V+ + A D D   N  L + ++G      F++ P+TG ++L + LD ET+
Sbjct: 1324 VLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQ 1383

Query: 99   SEFTVEFSVSDHQG----VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
            S + +  +  D QG      T  V I V D NDN P+F        I EN P+GT +  V
Sbjct: 1384 SLYKLNITAKD-QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442

Query: 155  NATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
             A DPD    G + Y+     P    F ID  +G +    E+D E    ++LTV A DQ 
Sbjct: 1443 TAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQ- 1501

Query: 212  KTRPLST----LANLAIIITDVQDMDPIFINLPYSTNIYEHSPP---GTTVRIITAIDQD 264
               P+ T    L N+ I++TD+ D  P+FI    S N     P    G+ +  I A D D
Sbjct: 1502 -AVPIETRRYALKNVTILVTDLNDNVPMFI----SQNALAADPSAVIGSVLTTIMAADPD 1556

Query: 265  KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
            +G    I Y I++G+T++ F +D  SG L +   L     +Y+    L V  T+L  +R 
Sbjct: 1557 EGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALVPSQLIYN----LIVSATDLGPERR 1611

Query: 325  PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
             S    TT   I++  ++   P F   +Y   + E   +G      +  ++     G  +
Sbjct: 1612 KS----TTELTIILQGLD--GPVFTQPKYITILKEGEPIGTN----VISIEAASPRGSEA 1661

Query: 385  MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANESVP--DHV 441
              E Y+V        +      G+    I+ A  LD E     Y  D++A E        
Sbjct: 1662 PVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRT 1721

Query: 442  GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFS 500
              A+V+ITL + NDN P+F   + ++++ EN+  G+ ++ + A D D G    V+Y   S
Sbjct: 1722 QRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIIS 1781

Query: 501  DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPT 560
               D F +D ++G ++   RLD E   +++L + A D G + +  R+ I V DVND+ P 
Sbjct: 1782 GADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRINITVSDVNDHTPK 1840

Query: 561  FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
            F +  Y   + E+    + +  + ATD+DS  N +ITY +      G +F   L    GV
Sbjct: 1841 FSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFF---LNPITGV 1897

Query: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
             +++R LDYE        LTV A D G     +T+ V   + D NDNPP FS  +Y  S+
Sbjct: 1898 FNLTRLLDYEV--QQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSL 1953

Query: 681  VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKS 740
            +EN+  G+TVL  N TD D          I S +   QF ++ ++G +     LDRE++S
Sbjct: 1954 MENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQS 2012

Query: 741  EYILIVRAVD-GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 799
             Y L+V+  D   +  ++ T  A V+I LLD+NDN PT+  +P    + E TP D+ V  
Sbjct: 2013 FYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFL-SPKLTYIPENTPIDTVVFK 2071

Query: 800  VVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIV 857
              A DPD G N  + Y++  P  NKF S+ +  G++R T   LDRE    +       + 
Sbjct: 2072 AQATDPDSGPNSYIEYTLLNPLGNKF-SIGTIDGEVRLT-GELDREEVSNYT------LT 2123

Query: 858  VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 917
            V  TD G+P L  +SS  V V +LD+NDN+P F    +  E+ E    G  I QV A D 
Sbjct: 2124 VVATDKGQPSL--SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADG 2181

Query: 918  DEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSS 977
            DEG NG V Y +  G    +F I+S +G +     LDRE+   Y L V A+D G+  ++ 
Sbjct: 2182 DEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD 2241

Query: 978  TSTLTIHVLDVNDETPTFFPAVYNVSVSEDV---PREFRVVWLNCTDNDVGLNAELSYFI 1034
            TST++I +LD+ND  P F  + Y+V+V E++   PR   ++ +   D+D G N++LSY +
Sbjct: 2242 TSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT--ILQVVARDDDRGSNSKLSYVL 2299

Query: 1035 TGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
             GGN D  F++      +     LDRET   ++L++ A D+G      TGT T+ V V D
Sbjct: 2300 FGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATDSGSPAL--TGTGTINVIVDD 2356

Query: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHV 1154
            VNDN P F   +Y  ++PED P G  +L + A+DAD  +   +  RI+ GN  + F I+ 
Sbjct: 2357 VNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIGGN--SQFTINP 2412

Query: 1155 SNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFTQQ 1211
            S G ++     LDRE   ++ L+V     D G   P+ SS  V+V V D+ND  P F   
Sbjct: 2413 STGQIITSAL-LDRETKDNYTLVVVC--SDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHH 2469

Query: 1212 QYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYL 1271
             Y       T   G+ V  V  TD D G    ++Y +      KF ID   G I+    L
Sbjct: 2470 PYVTHIPSPTLP-GSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPL 2528

Query: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD-EAVQFSNASYEAAILENLALGT 1330
            +  ++ ++ ++V      P  +    +V +  +N+ D   V+    ++     EN  + +
Sbjct: 2529 NGASEVTFSVHVKDGGSFPKTDS--TTVTVRFVNKADFPKVRAKEQTF--MFPENQPVSS 2584

Query: 1331 EIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVV 1390
             +  +   S+       Y      S      F+ID +TG +++   +D EK   Y + + 
Sbjct: 2585 LVTTITGSSLRGEPMSYY----IASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIE 2640

Query: 1391 ADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
            A DGG P   S  K+ ITVLD NDN+P F    D  +S   +    +++ TV A D D+G
Sbjct: 2641 ARDGGFPPFSSYEKLDITVLDVNDNAPIFK--EDPFISEILENLSPRKILTVSAMDKDSG 2698

Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
             NGQ+ + + +GN+  +F I   N + GE+   RPLDRE++ HY+L + +SD+G+P +  
Sbjct: 2699 PNGQLDYEIVNGNMENSFSI---NHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQST 2755

Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
               + + ILD NDN P     F  +V  N  +G    V +V  +D DIGIN++  Y I +
Sbjct: 2756 SVKVMINILDENDNAPRFSQIFSAHVPENSPLG--YTVTRVTTSDEDIGINAISRYSIMD 2813

Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
             +  + F ++  +G+I     P +RE    Y +  +  D G    + +T V + + D ND
Sbjct: 2814 AS--LPFTINPSTGDIVIS-RPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDIND 2867

Query: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHM 1689
            NAP F +  Y +   E  + + + +  + A D DEG NG V Y I + +    FRI+   
Sbjct: 2868 NAPRFSRTSYYLDCPELTE-IGSKVTQVFATDPDEGSNGQVFYFIKSQS--EYFRINATT 2924

Query: 1690 GVITAAKELDYE-------ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
            G I   + L Y+       ++  R++ IVT++D+       L S TTV +N+ D NDN P
Sbjct: 2925 GEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG---KPSLISETTVTINIVDSNDNAP 2981

Query: 1743 TFPRD-YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVL 1801
             F +  Y  P           +      D+D G N +VEY I + + LG+F +    G +
Sbjct: 2982 QFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWI 3041

Query: 1802 RVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITIS 1861
             V   +  D     F  +T+ A+D+G PPLSS   V I V + N + P      M+ TI 
Sbjct: 3042 SVASSLISDLNQNFF--ITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099

Query: 1862 ENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPE 1921
            E+  + S V  V A D D+  N  + ++I++GN E  F IN++TGI+T+ + LD E   +
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159

Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
            +++TIS  D      +AR  Y  + + + D NDN P+F    Y   V+EN+P+GT +  L
Sbjct: 3160 HEMTISAID---GGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216

Query: 1982 NGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
            N    A DAD    AV+ Y +  + S LF I+ +TGV+T +    +D E      L +  
Sbjct: 3217 N----ATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQG--FLDFETKQSYHLTVKA 3270

Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
                     S A + I +   N+  P F        + E  P G  V +V A+D D G +
Sbjct: 3271 FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTD 3330

Query: 2102 GELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
            GE+ Y I   ++ + F I+  TG I V +  +DRE++E   L V+A + G++  +    V
Sbjct: 3331 GEVHYLIFGNSRKKGFQINKKTGQIYV-SGILDREKEERVSLKVLAKNFGSIRGADIDEV 3389

Query: 2161 TILID--DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP---KLEYHIVGIV 2215
            T+ +   D ND  P F   I +V + E    GT +  ++A D D  P   +  Y I    
Sbjct: 3390 TVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS-- 3446

Query: 2216 AKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
                      N+  AF++N  TG + V + ++RE +  Y +++  +D+ +       +  
Sbjct: 3447 ---------GNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT-----PSATG 3492

Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN-GLVTYT 2334
            +A L V + D+NDN P      +T     ++E   PGT ++ + + DPD   N G  TY 
Sbjct: 3493 SASLLVTLEDINDNGPM-----LTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYY 3547

Query: 2335 LLDLVP-PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
            LL   P   Y  L  S+AG +   R +D E++     +V   D+G P  ++   V++ ++
Sbjct: 3548 LLSTGPATSYFSL--STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVI 3605

Query: 2394 DINDNNPIFDQPSYQEAV------FEDVPVGTIILTVTATDADSGNFALIEYSLGDG-ES 2446
            D NDN      PS    V      + ++  G I+ +V   D D         SL  G  S
Sbjct: 3606 DQNDN------PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV--LDSFHCSLTSGVTS 3657

Query: 2447 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDN-PGDVASNRR 2489
             F+I   T D   L+S  R     + LT L+ D     V SN R
Sbjct: 3658 LFSIPGGTCD---LNSQPRSTDGTFDLTVLSNDGVHSTVTSNIR 3698



 Score =  865 bits (2236), Expect = 0.0
 Identities = 778/2653 (29%), Positives = 1227/2653 (46%), Gaps = 214/2653 (8%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPD----- 83
            P F +  +  Y    E+   GS V ++ A D D     FG +GE    F  V+PD     
Sbjct: 1098 PLFNSTNYTFYF--EEEQRAGSFVGKVSAVDKD-----FGPNGEVRYSFEMVQPDFELHA 1150

Query: 84   -TGVVWLRQPLDRET--KSEFTVEFS---VSDHQGVIT-----RKVNIQVGDVNDNAPTF 132
             +G +      DRE+  +   T  FS   ++  QG+         V++ + D+NDNAP F
Sbjct: 1151 ISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKF 1210

Query: 133  HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVI 190
                Y   I E+    T +  V+A+D D G  G + YS    ++   FAIDS  G VT+I
Sbjct: 1211 LKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLI 1270

Query: 191  RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
             +LDYE T AY L + A D   T PL++   L I I D  D  P F       ++ E+  
Sbjct: 1271 GKLDYEATPAYSLVIQAVDSG-TIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMR 1329

Query: 251  PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
             G  V  +TA D D G    + Y+I   N +  F++   +G + L   LD E        
Sbjct: 1330 IGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQS----- 1384

Query: 311  ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
            +  +  T  +  R P  +T++   ++   D NDN P F   +   +I E   +G ++   
Sbjct: 1385 LYKLNITAKDQGRPPRSSTMSVVIHVR--DFNDNPPSFPPGDIFKSIVENIPIGTSV--- 1439

Query: 371  IQVVDKDENLGLNSMFEVYLVGN--NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428
            I V   D +  +N      ++      +HF I    V+G     I     +D E  + ++
Sbjct: 1440 ISVTAHDPDADINGQLSYTIIQQMPRGNHFTID--EVKGT----IYTNAEIDREFANLFE 1493

Query: 429  FDLFANE-SVPDHVG-YAKVKITLI--NENDNRPIFSQPLYNISLYENVTVGTSVLTVLA 484
              + AN+ +VP     YA   +T++  + NDN P+F      ++   +  +G+ + T++A
Sbjct: 1494 LTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQ-NALAADPSAVIGSVLTTIMA 1552

Query: 485  TDNDAGTFGEVSY-FFSDDPDRFSLDKDTG-LIMLIARLDYELIQRFTLTIIARDGGGEE 542
             D D G  GE+ Y   + D D F +D+ +G L +  A +  +LI  + L + A D G E 
Sbjct: 1553 ADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPSQLI--YNLIVSATDLGPER 1610

Query: 543  TTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQ--ITYSI 600
                  + ++    + P F +  Y+  L+E EP  T ++ + A    SP  ++  + Y I
Sbjct: 1611 RKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA---SPRGSEAPVEYYI 1667

Query: 601  VSA----SAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT-VMAMDAGNP-PLNST 654
            VS        G  F I  + G  +I  +  LD EQ     +YL  V A++     P    
Sbjct: 1668 VSVRCEEKTVGRLFTIGRHTG--IIQTAAILDREQ--GACLYLVDVYAIEKSTAFPRTQR 1723

Query: 655  VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
              V I + D NDNPP F      ++V ENI  G+ ++ L A D D   E     + Y++ 
Sbjct: 1724 AEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDAD---EGANALVTYTII 1780

Query: 715  GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
                  FRI+  SG++  T  LDRE +S+Y L+VRA DG    + +     +NIT+ D+N
Sbjct: 1781 SGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMR-----INITVSDVN 1835

Query: 773  DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTT 830
            D+ P +    Y  ++ E T P S V  ++A D D G NG + Y +   ++   + LN  T
Sbjct: 1836 DHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPIT 1895

Query: 831  GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
            G    T  +LD      +E +    + V   D G       ++  V+ N+LD+NDN P F
Sbjct: 1896 GVFNLTR-LLD------YEVQQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIF 1944

Query: 891  QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT 950
                +   ++E +P G ++      D D+G+N  ++Y +  G     F ++ + GV+   
Sbjct: 1945 SLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVL 2003

Query: 951  TELDRERIAEYQLRVVASDAGTPTKS---STSTLTIHVLDVNDETPTFFPAVYNVSVSED 1007
              LDRE  + Y L V   D      S   ST+ ++I +LDVND  PTF        + E+
Sbjct: 2004 KALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPEN 2062

Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
             P +  V     TD D G N+ + Y +    +  KFS+G  D  VR    LDRE  + Y 
Sbjct: 2063 TPIDTVVFKAQATDPDSGPNSYIEYTLLNP-LGNKFSIGTIDGEVRLTGELDREEVSNYT 2121

Query: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKAT 1127
            L + A D G      + +  V V VLD+NDN PIF Q+ Y+  + E+   G  I+Q+ A 
Sbjct: 2122 LTVVATDKGQPSL--SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAA 2179

Query: 1128 DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1187
            D DEG  G+V Y I++GN    FRI    G +    +PLDRE+  ++ L V+A +    P
Sbjct: 2180 DGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVA-KPLDREKTPTYHLTVQATDRGSTP 2238

Query: 1188 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG-IGTSVIVVQATDRDSGDGGLVNY 1246
               +  V + + DIND  PVF    YS + + E  G +  +++ V A D D G    ++Y
Sbjct: 2239 RTDTSTVSIVLLDINDFVPVFELSPYS-VNVPENLGTLPRTILQVVARDDDRGSNSKLSY 2297

Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
             +  G E       ++G +     LD ETK  +++ ++ATD   P   G  ++ + + + 
Sbjct: 2298 VLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDV 2357

Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
             D    F++ +Y   I E+   GT+++ V A   D       R     S      F I+ 
Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ-----FTINP 2412

Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGGPK--VDSTVKVYITVLDENDNSPRFDFTSDS 1424
             TG I    L+DRE  D YTL VV  D G    + S+  V +TV D NDN PRF      
Sbjct: 2413 STGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQH-HPY 2471

Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
               IP     G  V  V   D D G N ++ +SL SG  +  F I       G +  A P
Sbjct: 2472 VTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLR---GAIMAAGP 2527

Query: 1485 LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGG 1544
            L+          V   D G+ P+     + V  ++  D P V      +    N+ V   
Sbjct: 2528 LNGAS--EVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSL 2585

Query: 1545 TAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVA 1604
               +   +   +      +SYYI  GN    F++D+++G+++    P D E+   Y +  
Sbjct: 2586 VTTITGSSLRGE-----PMSYYIASGNLGNTFQIDQLTGQVSISQ-PLDFEKIQKYVVWI 2639

Query: 1605 TVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--EVLLDEGPDTLNTSLITIQALDL 1662
               D G P  S+   + +T++D NDNAP+F++  +  E+L +  P      ++T+ A+D 
Sbjct: 2640 EARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP----RKILTVSAMDK 2695

Query: 1663 DEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILS 1721
            D GPNG + Y IV GN+ N+F I+   G I + + LD E +SH  Y L + ++D+    S
Sbjct: 2696 DSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSH--YVLTIKSSDKG---S 2750

Query: 1722 HRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVE 1780
               +++  V++N+ D NDN P F + +     V E  P G  V      D D G N    
Sbjct: 2751 PSQSTSVKVMINILDENDNAPRFSQIFSA--HVPENSPLGYTVTRVTTSDEDIGINAISR 2808

Query: 1781 YSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
            YSIMD      F I+P  G + + +   L+RE    Y + + A D G    +    V I 
Sbjct: 2809 YSIMDASL--PFTINPSTGDIVISRP--LNREDTDRYRIRVSAHDSGWTVSTD---VTIF 2861

Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1900
            V DINDN P        +   E + + S V  V A+D D G N ++ + I +  +   F 
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKS--QSEYFR 2919

Query: 1901 INATTGIVTVNRPLDRERIP--------EYKLTISVKDNPENPRIARRDYDLLLIFLSDE 1952
            INATTG +   + L  + +          +   ++  D  +   I+     + ++   D 
Sbjct: 2920 INATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV---DS 2976

Query: 1953 NDNHPLFTKSTYQAEVMENSPAGTPL---TVLNGPILALDADQDIYAVVTYQLLGAQSGL 2009
            NDN P F KS Y   V +N   GT L   T ++     L+++ + +      L     G 
Sbjct: 2977 NDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHL-----GK 3031

Query: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRP 2067
            F +++ TG ++V S +I D          + + A+D G   L+S A + IT+ ++N + P
Sbjct: 3032 FKLDNDTGWISVASSLISDLNQN----FFITVTAKDKGNPPLSSQATVHITVTEENYHTP 3087

Query: 2068 TFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR-FLIHLVTGVIR 2126
             FS + ++  + E+   G  V  V+A D D+ +NG + Y I +G ++  F I+  TG++ 
Sbjct: 3088 EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILT 3147

Query: 2127 VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLES 2186
            +  A +D E  + + +T+ A D G V  +G   VT+ + D+ND+ P FL+     +VLE+
Sbjct: 3148 LAKA-LDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLEN 3206

Query: 2187 AEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS 2244
            A  GT + ++ A D D   N  + Y +              +  D F ++ NTG +  + 
Sbjct: 3207 APSGTTVIHLNATDADSGTNAVIAYTVQS------------SDSDLFVIDPNTGVITTQG 3254

Query: 2245 PMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMER 2304
             ++ E   +Y +T+    N  D    S +  N +L       N+  P+F      YY E 
Sbjct: 3255 FLDFETKQSYHLTVKAF-NVPDEERCSFATVNIQLK----GTNEYVPRF--VSKLYYFE- 3306

Query: 2305 ILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEE 2364
            I E A  GT +  V A D D G +G V Y +         Q+ +   G++  +  +D E+
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI-NKKTGQIYVSGILDREK 3365

Query: 2365 VHWLNFTVRASDNGSPPRAA--EIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL 2422
               ++  V A + GS   A   E+ V + ++D ND  PIF    Y   + E VP+GT + 
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVT 3424

Query: 2423 TVTATDADS-GNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKD 2479
             V+A D+DS  +++   Y +G G     F+INP TG I V + LDRE    Y L+ LA D
Sbjct: 3425 FVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD 3484

Query: 2480 NPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEG 2539
            +    A+     S  +++ + D+ND  P  +  +    V EN+  GT V+T+ +TD D  
Sbjct: 3485 SGTPSATG----SASLLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQSTDPDLP 3538

Query: 2540 PN-GELTYSL--EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGT 2594
            PN G  TY L   GP    F +   +G+++T R +  +    F L+VV  D G P +  T
Sbjct: 3539 PNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSST 3597

Query: 2595 TMLLVEVIDVNDN 2607
              + + VID NDN
Sbjct: 3598 GTVHITVIDQNDN 3610



 Score =  593 bits (1528), Expect = e-168
 Identities = 520/1719 (30%), Positives = 807/1719 (46%), Gaps = 151/1719 (8%)

Query: 1249 LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD 1308
            LS +   F I+ STG + T + +D E+  S ++N+     AP +      V + + +  D
Sbjct: 74   LSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPT---EVRVLVRDLND 130

Query: 1309 EAVQFSNASYEAAILENLALGTEIVRVQAYSID-NLNQITYRFNAYTSTQAKALFKIDAI 1367
             A  F + S      E+ + G +++   A   D   N + +R            F++D  
Sbjct: 131  NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190

Query: 1368 TGV--------ITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRF 1418
                       +  +G +DRE    Y L V V D G PK    ++V +TV D NDN P F
Sbjct: 191  LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVF 250

Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
              +S     +PED  VG  V  V A D D G+N  + + L         +  T     G 
Sbjct: 251  G-SSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPET-----GL 304

Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF----GYN 1534
            + V  PLD E    Y L V A DRG P         + +LD+NDN PV++  +       
Sbjct: 305  ITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRY 364

Query: 1535 VSVNENVGGGTAVVQVRATDRDI-GINSVLSYYITEGNKDMAFRMD--RISGEIATRPAP 1591
             SV+EN   GT V  +  TD D    N  +S  I  GN+   F +   ++      + A 
Sbjct: 365  ASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVAS 424

Query: 1592 P-DRERQSFYHLVATVEDE-GTP------TLSATTHVYVTIVDENDNAPMFQQPHYEV-L 1642
              DRER   Y+L  +V D  G P        S+   + + + D ND+ P+F Q  Y V L
Sbjct: 425  ALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNL 484

Query: 1643 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDY 1700
             +E P     S   I A D D G N  + Y+IV+GN +  F I  H G++T      LD 
Sbjct: 485  SEEAPPGSYVS--GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDR 542

Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759
            E++  +  L ++A DQ     H   S   ++V + D+ND  P F +       V E  P 
Sbjct: 543  ELA-SQIVLNISARDQGV---HPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPT 598

Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDP-LGEFVISPVEGVLRVRKDVELDRETIAFYN 1818
            G  +    A D D G NG V +S+ + +     F + PV G  R+     LDRE  AFY+
Sbjct: 599  GTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG--RLSTISSLDREEQAFYS 656

Query: 1819 LTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDA 1878
            L + A D G PP SS   + + +LDINDN PV   +     I EN P  S++  V A+D 
Sbjct: 657  LLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDP 716

Query: 1879 DSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPR 1936
            D G N  + ++I+AG+R R F +NA +G+++    LDRE    Y+L I   D  N ++P 
Sbjct: 717  DLGTNGTVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPN 775

Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYA 1996
             A     ++ I + D  DN P+F++  Y   V EN   G  +  ++   + L+++   Y 
Sbjct: 776  QA-----IVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNIS-YL 829

Query: 1997 VVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL 2056
            + T    G Q G+F IN  TG +T  +  +IDRE  S    +L ++A   G +     + 
Sbjct: 830  ITT----GDQKGMFAINQVTGQLTTAN--VIDREEQS--FYQLKVVASG-GTVTGDTMVN 880

Query: 2057 ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRF 2116
            IT+ D NDN P F  A  +V+++EN   G S+ Q  A D D G+NG ++Y ++   ++ F
Sbjct: 881  ITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLF 940

Query: 2117 LIHLVTGVIRV-GNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
             I+   G I + G   +      SY++ ++A+D G   LS + I+T+ + D+ND+ P F 
Sbjct: 941  AINEKNGTISLLGPLDV---HAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFD 997

Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
                 V++ ES    +    + A D D     E  I   +A+ +T        DAF +  
Sbjct: 998  QLSYEVTLSESEPVNSRFFKVQASDKDSGANGE--IAYTIAEGNTG-------DAFGI-F 1047

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP 2295
              G + +KS ++REL   Y + +   D A +    +V+V     TV + DVNDN P F  
Sbjct: 1048 PDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNV-----TVILEDVNDNRPLFNS 1102

Query: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
               T+Y E   E    G+ +  V+AVD D G NG V Y+  ++V P +     + +G++ 
Sbjct: 1103 TNYTFYFE---EEQRAGSFVGKVSAVDKDFGPNGEVRYSF-EMVQPDFEL--HAISGEIT 1156

Query: 2356 ANRTVDYEEVHW------LNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPSYQ 2408
                 D E +         +FTV A+D G P P   +  V++ + DINDN P F +  YQ
Sbjct: 1157 NTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQ 1216

Query: 2409 EAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDRE 2466
              + E     T +L V+A+D D GN  LI YS+  G+ E +FAI+ T+G + ++  LD E
Sbjct: 1217 ATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYE 1276

Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
                Y L   A D+ G +  N   ++  + I +LD ND  P F K      V EN   G 
Sbjct: 1277 ATPAYSLVIQAVDS-GTIPLN---STCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGE 1332

Query: 2527 SVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSYEKFSLTVVA 2583
             V ++ ATD D G N +L YS+ G      F +  ++G +   + L  ++   + L + A
Sbjct: 1333 LVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITA 1392

Query: 2584 TDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEG 2643
             D G PP   T  +++ V D NDN P F  PP      I E IP+ ++V  V A D D  
Sbjct: 1393 KDQGRPPRSSTMSVVIHVRDFNDNPPSF--PPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450

Query: 2644 LNGAVRYSFLKTA--GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVP 2701
            +NG + Y+ ++    GN     F ID + G I T   +DRE   ++ L + A+D  Q VP
Sbjct: 1451 INGQLSYTIIQQMPRGNH----FTIDEVKGTIYTNAEIDREFANLFELTVKAND--QAVP 1504

Query: 2702 YET----MQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDAD 2757
             ET    ++ + + + D++DN P+F+           L     +  G+++  +  A D D
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMFI-------SQNALAADPSAVIGSVLTTIMAA-DPD 1556

Query: 2758 EGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
            EG N  + Y I  G+ +     +  G L V   L    + I++ IV A+      P R  
Sbjct: 1557 EGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPS-QLIYNLIVSATD---LGPERRK 1612

Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
            S T          E+ ++L+ ++   P FT+ +Y   +     +G+ +I + A     G+
Sbjct: 1613 STT----------ELTIILQGLDG--PVFTQPKYITILKEGEPIGTNVISIEAASPR-GS 1659

Query: 2878 NSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT 2916
             + V Y I+++        + + VG++FT+G   GI++T
Sbjct: 1660 EAPVEYYIVSVRC------EEKTVGRLFTIGRHTGIIQT 1692



 Score =  391 bits (1005), Expect = e-108
 Identities = 333/1096 (30%), Positives = 521/1096 (47%), Gaps = 66/1096 (6%)

Query: 25   VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDT 84
            VN+  F      +   +  E+ PV S VT +    +  +P+ + ++       F ++  T
Sbjct: 2559 VNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLT 2618

Query: 85   GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRI 141
            G V + QPLD E   ++ V     D          K++I V DVNDNAP F   P+   I
Sbjct: 2619 GQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEI 2678

Query: 142  PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
             EN      I  V+A D D G  G + Y     +    F+I+ A G +  +R LD E   
Sbjct: 2679 LENLS-PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVS 2737

Query: 200  AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
             Y LT+ ++D+      ST   + I I D  D  P F  + +S ++ E+SP G TV  +T
Sbjct: 2738 HYVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVT 2795

Query: 260  AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
              D+D G      Y+I+  +    F ++  +G + ++  L+RE+   +  + + V   + 
Sbjct: 2796 TSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNRED---TDRYRIRVSAHD- 2849

Query: 320  NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
                  S  TV+T   I V DINDNAP F+ + Y +   EL ++G  +    QV   D +
Sbjct: 2850 ------SGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKV---TQVFATDPD 2900

Query: 380  LGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
             G N     Y + + S +F I+ T+  +  K  ++ +         ++R+ F + +++  
Sbjct: 2901 EGSNGQV-FYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG 2959

Query: 437  VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN-DAGTFGEV 495
             P  +    V I +++ NDN P F +  Y   + +NV VGT ++ V A D+ D G   EV
Sbjct: 2960 KPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEV 3019

Query: 496  SYFFSDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR--VRINV 551
             YF S+D    +F LD DTG I + + L  +L Q F +T+ A+D G    + +  V I V
Sbjct: 3020 EYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITV 3079

Query: 552  LDVNDNVPTFQKDAYVGALRENEPSVTQLVR-LRATDEDSPPNNQITYSIVSASAFGSYF 610
             + N + P F + +++ A      S+  +VR + A D D+  N  I YSI S +  G + 
Sbjct: 3080 TEENYHTPEFSQ-SHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIF- 3137

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
              ++    G++++++ LDYE        +T+ A+D G         VT+ V D NDN P 
Sbjct: 3138 --AINSSTGILTLAKALDYELCQKH--EMTISAIDGGWVARTGYCSVTVNVIDVNDNSPV 3193

Query: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSTQ--FRINARSGE 727
            F    YF +V+EN  +G TV+ LNATD D     G  ++I Y+++ S    F I+  +G 
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADS----GTNAVIAYTVQSSDSDLFVIDPNTGV 3249

Query: 728  ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
            ITT   LD ETK  Y L V+A +  V   ++   ATVNI L   N+  P +    YY  +
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEI 3307

Query: 788  VEMTPPDSDVTTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAMLDRENP 845
             E  P  + V  V A D DLG +G + Y I      K + +N  TG+I  +  +LDRE  
Sbjct: 3308 SEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVS-GILDREKE 3366

Query: 846  DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
            +    +++ K   S+              TV V +LD ND  P F    +  ++ EG+P 
Sbjct: 3367 ERVSLKVLAKNFGSIRGAD------IDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPI 3419

Query: 906  GVSIYQVVAIDLDEGLN-GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR 964
            G  +  V A D D   +    SY +  G     F IN  +G +  T ELDRE +  Y L 
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLS 3479

Query: 965  VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
            V+A D+GTP+ + +++L + + D+ND  P     V    V E+      V+ L  TD D+
Sbjct: 3480 VLAVDSGTPSATGSASLLVTLEDINDNGPML--TVSEGEVMENKRPGTLVMTLQSTDPDL 3537

Query: 1025 GLNAE--LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRH 1082
              N      Y ++ G     FS+     V+ T   +DRE  A + L +   D+G    + 
Sbjct: 3538 PPNQGPFTYYLLSTGPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGV--PQM 3594

Query: 1083 TGTATVFVTVLDVNDN 1098
            + T TV +TV+D NDN
Sbjct: 3595 SSTGTVHITVIDQNDN 3610



 Score =  239 bits (609), Expect = 4e-62
 Identities = 226/745 (30%), Positives = 329/745 (44%), Gaps = 93/745 (12%)

Query: 2177 PIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236
            P Q   VLE   PGT++  I        P   Y +                   FA+N +
Sbjct: 45   PRQVFQVLEEQPPGTLVGTIQT-----RPGFTYRL-------------SESHALFAINSS 86

Query: 2237 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF 2296
            TG++   S ++RE + +  + L V+ +A   P         ++ V V D+NDN P F   
Sbjct: 87   TGALYTTSTIDRESLPSDVINLVVLSSAPTYP--------TEVRVLVRDLNDNAPVFPDP 138

Query: 2297 GITYYMERILEGATPGTTLIAVAAVDPDKGLNGLV--TYTLLDLVPPGYVQLE------- 2347
             I    +   E ++ G  +I   A D D G NG+   +Y ++     G  +L+       
Sbjct: 139  SIVVTFK---EDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSG 195

Query: 2348 DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
            + +   +++   +D E        V   D G P R   + V + + DINDN P+F    Y
Sbjct: 196  EGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHY 255

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREK 2467
            Q  V ED  VG+ +L V A DAD G  A I Y L D  + F ++P TG I V   LD E 
Sbjct: 256  QAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEA 315

Query: 2468 KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP-----QFSKPQFSTSVYENE 2522
            +  Y LT  A D      + R E     +IQ+LDVND  P      F       SV EN 
Sbjct: 316  RRQYSLTVQAMDRGVPSLTGRAE----ALIQLLDVNDNDPVVKFRYFPATSRYASVDENA 371

Query: 2523 PAGTSVITMMATDQDE-GPNGELTYSLEGPGVEAFHVDMDSG--------LVTTQRPLQS 2573
              GT V  +  TD D    NG ++  + G G E  H ++ S          V +    + 
Sbjct: 372  QVGTVVALLTVTDADSPAANGNISVQILG-GNEQRHFEVQSSKVPNLSLIKVASALDRER 430

Query: 2574 YEKFSLTVVATDG-GEPP------LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEI 2626
               ++LTV  +D  G PP            L++ V D+ND+ PVF +      +++ EE 
Sbjct: 431  IPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYR--VNLSEEA 488

Query: 2627 PLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR--LDRESQ 2684
            P  S V  + ATD D GLN  +RYS +   G     +F I   SGL+ T     LDRE  
Sbjct: 489  PPGSYVSGISATDGDSGLNANLRYSIVSGNG---LGWFHISEHSGLVTTGSSGGLDRELA 545

Query: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRG 2744
            +   L + A D G   P  +   L V L D++D +P+F       P+   ++V E++P G
Sbjct: 546  SQIVLNISARDQGVH-PKVSYAQLVVTLLDVNDEKPVF-----SQPEGYDVSVVENAPTG 599

Query: 2745 TLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFI 2802
            T +  +  A D D G N  V + +  A  + ++F L P  G L  +  LDRE +A +S +
Sbjct: 600  TEL-LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLL 658

Query: 2803 VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVG 2862
            V A+   S  PP+            ++  + V L DIND  P F   +Y A +  +   G
Sbjct: 659  VLATDLGS--PPQS-----------SMARINVSLLDINDNSPVFYPVQYFAHIKENEPGG 705

Query: 2863 SELIQVLALDADIGNNSLVFYSILA 2887
            S +  V A D D+G N  V YSI A
Sbjct: 706  SYITTVSATDPDLGTNGTVKYSISA 730



 Score =  130 bits (326), Expect = 3e-29
 Identities = 157/545 (28%), Positives = 231/545 (42%), Gaps = 64/545 (11%)

Query: 30   FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
            F ++ +F T L   E+ P G++V  L A D D   N  + + V   + S  F ++P+TGV
Sbjct: 3194 FLSDDYFPTVL---ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNTGV 3249

Query: 87   VWLRQPLDRETKSEF--TVE-FSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
            +  +  LD ETK  +  TV+ F+V D +      VNIQ+   N+  P F ++ Y   I E
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISE 3309

Query: 144  NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
              P GT +  V A+D DLG  G V Y     S+   F I+   G + V   LD E  +  
Sbjct: 3310 AAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERV 3369

Query: 202  QLTVNATDQDKTRPLST-LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITA 260
             L V A +    R        + + + D  D  PIF    YS  I E  P GT V  ++A
Sbjct: 3370 SLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSA 3428

Query: 261  IDQDKGRPRG-IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTE 318
             D D         Y I SGN N  F+++  +G +T+   LDRE  P+Y+   +       
Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAV----- 3483

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD- 377
              D  TPS AT + +  + + DINDN P    SE  V   E  + G  L + +Q  D D 
Sbjct: 3484 --DSGTPS-ATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPG-TLVMTLQSTDPDL 3537

Query: 378  -ENLGLNSMFEVYLV--GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
              N G    F  YL+  G  + +F +S   V       +     +D E +  +   +   
Sbjct: 3538 PPNQG---PFTYYLLSTGPATSYFSLSTAGV-------LSTTREIDREQIADFYLSVVTK 3587

Query: 435  ES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
            +S VP       V IT+I++NDN          ++ Y N+  G             G  G
Sbjct: 3588 DSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPG-------------GILG 3634

Query: 494  EVSYFFSDDPDRFSLDKDTGLIMLIA----RLDYELIQR-----FTLTIIARDGGGEETT 544
             V     D  D F     +G+  L +      D     R     F LT+++ DG     T
Sbjct: 3635 SVKPQDPDVLDSFHCSLTSGVTSLFSIPGGTCDLNSQPRSTDGTFDLTVLSNDGVHSTVT 3694

Query: 545  GRVRI 549
              +R+
Sbjct: 3695 SNIRV 3699


>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
          Length = 530

 Score =  967 bits (2501), Expect = 0.0
 Identities = 483/485 (99%), Positives = 484/485 (99%)

Query: 1   MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
           MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1   MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60

Query: 61  DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
           DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61  DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120

Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
           QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180

Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
           DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240

Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
           YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300

Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
           RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360

Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
           AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420

Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
           YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480

Query: 481 TVLAT 485
           TVL +
Sbjct: 481 TVLVS 485



 Score =  192 bits (488), Expect = 5e-48
 Identities = 141/465 (30%), Positives = 232/465 (49%), Gaps = 42/465 (9%)

Query: 677  FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEITTTSL 733
            ++ + E+   G++V  L A D+D       + +++ + G   S  F +   +G +     
Sbjct: 39   YLLISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQP 92

Query: 734  LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
            LDRETKSE+      V+  V  +Q      VNI + D+NDN PT+ + PY + + E TP 
Sbjct: 93   LDRETKSEF-----TVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147

Query: 794  DSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELM 853
             + +  V A DPDLG  G+++YS QPP++F++++S  G I T    LD E    ++    
Sbjct: 148  GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARG-IVTVIRELDYETTQAYQ---- 202

Query: 854  RKIVVSVTDCGRP-PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
              + V+ TD  +  PL   ++  + +   D+ D DP F NLP+   + E  P G ++  +
Sbjct: 203  --LTVNATDQDKTRPLSTLANLAIIIT--DVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258

Query: 913  VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA----- 967
             AID D+G    + Y +  G     F ++  SGV+     LDRE        ++      
Sbjct: 259  TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318

Query: 968  -SDAGTPTKSS-TSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV-VWLNCTDND- 1023
             +D  TP+ ++ T+T  I V+D+ND  P F  + Y+V+++E     F + +++   D D 
Sbjct: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378

Query: 1024 -VGLNAELSYFITGGN-----VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
             +GLN+    ++ G N     +      G  D  +R  + LD ET   Y   L A ++ P
Sbjct: 379  NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVP 438

Query: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIL 1122
                H G A V +T+++ NDNRPIF Q  Y  S+ E++  G S+L
Sbjct: 439  ---DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480



 Score =  158 bits (399), Expect = 1e-37
 Identities = 148/483 (30%), Positives = 229/483 (47%), Gaps = 44/483 (9%)

Query: 1957 PLFTKSTYQAEVM--ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDIN 2013
            P FT   +   ++  E++P G+ +T L    LA D D D    + + + G + S  F + 
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQL----LAQDMDND---PLVFGVSGEEASRFFAVE 81

Query: 2014 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2073
              TGVV +R    +DRE  S   +E  + ++  G++  T  + I + D NDN PTF    
Sbjct: 82   PDTGVVWLRQP--LDRETKSEFTVEFSV-SDHQGVI--TRKVNIQVGDVNDNAPTFHNQP 136

Query: 2074 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATID 2133
             +V + EN P G  +  V ATD D G  G ++Y  +  +Q  F I    G++ V    +D
Sbjct: 137  YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTV-IRELD 194

Query: 2134 REEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTV 2192
             E  ++Y+LTV ATD+  T PLS  A + I+I D+ D  P F+N   + ++ E + PGT 
Sbjct: 195  YETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTT 254

Query: 2193 IANITAIDHDL-NPK-LEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNREL 2250
            +  ITAID D   P+ + Y IV             N    FA++  +G + +   ++RE 
Sbjct: 255  VRIITAIDQDKGRPRGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDREN 303

Query: 2251 VATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL--DVNDNTPQFKPFGITYYMERILEG 2308
                   +  +       +R+ S      T N+L  D+NDN P+F     + Y   I E 
Sbjct: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS---SEYSVAITEL 360

Query: 2309 ATPGTTL---IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV----D 2361
            A  G  L   I V   D + GLN +    L+      ++    S  GK      V    D
Sbjct: 361  AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420

Query: 2362 YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTII 2421
            YE V   +F + A+++  P       V + +++ NDN PIF QP Y  +++E+V VGT +
Sbjct: 421  YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479

Query: 2422 LTV 2424
            LTV
Sbjct: 480  LTV 482



 Score =  158 bits (399), Expect = 1e-37
 Identities = 150/473 (31%), Positives = 226/473 (47%), Gaps = 55/473 (11%)

Query: 1111 VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN----FRIHVSNGLLMRGPRPL 1166
            + ED P G S+ QL A D D          ++ G  G      F +    G++    +PL
Sbjct: 42   ISEDTPVGSSVTQLLAQDMDNDP-------LVFGVSGEEASRFFAVEPDTGVVWLR-QPL 93

Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT 1226
            DRE  S   +     +H     R   +V + V D+ND AP F  Q YS + + E   +GT
Sbjct: 94   DRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS-VRIPENTPVGT 149

Query: 1227 SVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSAT 1286
             + +V ATD D G GG V Y     ++  F ID + G++  +  LDYET  +Y + V+AT
Sbjct: 150  PIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNAT 208

Query: 1287 DQ---APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNL 1343
            DQ    P       ++ IT + ++D    F N  Y   I E+   GT +  + A   D  
Sbjct: 209  DQDKTRPLSTLANLAIIITDVQDMDPI--FINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266

Query: 1344 NQITYRFNAYT--STQAKALFKIDAITGVITVQGLVDREKGDF---YTLTV----VADDG 1394
                 R   YT  S    ++F +D I+GV+T+ GL+DRE   +   + LTV    + DD 
Sbjct: 267  RP---RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323

Query: 1395 GPKVDSTVKVY--ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT---VKAWDPDAG 1449
             P  D+TV     I V+D NDN+P F+ +S+ +V+I E   VG  +     V   D + G
Sbjct: 324  TPS-DATVTTTFNILVIDINDNAPEFN-SSEYSVAITELAQVGFALPLFIQVVDKDENLG 381

Query: 1450 SNGQVVFSLASGNIAGAFEIVTTN---DSIGEVFVARPLDREELDHYILQVVASDRGTPP 1506
             N      L  GN +  F I  T+    +   + VA PLD E +D Y   + A++     
Sbjct: 382  LNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---- 436

Query: 1507 RKKDHI----LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
               DH+    +++T+++ NDN P+   P  YN+S+ ENV  GT+V+ V  + R
Sbjct: 437  -VPDHVGYAKVKITLINENDNRPIFSQPL-YNISLYENVTVGTSVLTVLVSPR 487



 Score =  151 bits (381), Expect = 1e-35
 Identities = 135/475 (28%), Positives = 216/475 (45%), Gaps = 36/475 (7%)

Query: 1632 PMFQQPHYEVLLDEGPDT-LNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMG 1690
            P F    ++  L    DT + +S+  + A D+D  P   + + +        F ++   G
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85

Query: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750
            V+   + LD E +   +T+  + +D      H+   T  V + V D+NDN PTF   +  
Sbjct: 86   VVWLRQPLDRE-TKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTF---HNQ 135

Query: 1751 PFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
            P+ V   E  P G  ++   A D D G  G V YS     P   F I    G++ V +  
Sbjct: 136  PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGIVTVIR-- 191

Query: 1808 ELDRETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPV 1866
            ELD ET   Y LT+ A D+    PLS+   + I + D+ D DP+ +NLP +  I E+SP 
Sbjct: 192  ELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP 251

Query: 1867 SSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER-IPEYKLT 1925
             + V  + A D D G    + + I +GN    F ++  +G++T+N  LDRE  +  +   
Sbjct: 252  GTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI 311

Query: 1926 ISVKDNPENPRIARRDYDLLLIF---LSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
            ++VK    N      D  +   F   + D NDN P F  S Y   + E +  G  L +  
Sbjct: 312  LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF- 370

Query: 1983 GPILALDADQD--IYAVVTYQLLGAQSGLFDINSST----GVVTVRSGVIIDREAFSPPI 2036
              I  +D D++  + ++    L+G  S  F I+ ++      + +R  + +D E      
Sbjct: 371  --IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428

Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
             + L   E +      A + IT++++NDNRP FS     + L EN   G SVL V
Sbjct: 429  FD-LFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482



 Score =  149 bits (375), Expect = 6e-35
 Identities = 150/498 (30%), Positives = 217/498 (43%), Gaps = 48/498 (9%)

Query: 440 HVGYAKVKITLINENDNR-PIFSQPLYNISLY--ENVTVGTSVLTVLATD--NDAGTFG- 493
           HV +  V I+      NR P F+   ++  L   E+  VG+SV  +LA D  ND   FG 
Sbjct: 10  HVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGV 69

Query: 494 ---EVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
              E S FF+ +PD       TG++ L   LD E    FT+     D  G   T +V I 
Sbjct: 70  SGEEASRFFAVEPD-------TGVVWLRQPLDRETKSEFTVEFSVSDHQGV-ITRKVNIQ 121

Query: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
           V DVNDN PTF    Y   + EN P  T +  + ATD D      + YS    S F    
Sbjct: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF---- 177

Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPP 669
             ++    G+++V R LDYE  +     LTV A D     PL++   + I + D  D  P
Sbjct: 178 -FAIDSARGIVTVIRELDYE--TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP 234

Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEIT 729
            F    Y  ++ E+   G TV  + A D D+ R  G    I S   ++ F ++  SG +T
Sbjct: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294

Query: 730 TTSLLDRET---KSEYILIVRAVDGGVGH--NQKTGIATVNITLLDINDNHPTWKDAPYY 784
              LLDRE       +IL V+  +       +  T   T NI ++DINDN P +  + Y 
Sbjct: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYS 354

Query: 785 INLVEMTPPDSDVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTT---GK--IRTT 836
           + + E+      +   + V   D +LG N      +   N  + + S T   GK  IR  
Sbjct: 355 VAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIR 414

Query: 837 HAM-LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
            A+ LD E  D ++ +L      SV D           A V + L++ NDN P F    +
Sbjct: 415 VAIPLDYETVDRYDFDLFAN--ESVPD-------HVGYAKVKITLINENDNRPIFSQPLY 465

Query: 896 VAEVLEGIPAGVSIYQVV 913
              + E +  G S+  V+
Sbjct: 466 NISLYENVTVGTSVLTVL 483



 Score =  143 bits (360), Expect = 3e-33
 Identities = 130/403 (32%), Positives = 181/403 (44%), Gaps = 30/403 (7%)

Query: 418 PLDYETVDRYDFDLFANESVPDHVGYA--KVKITLINENDNRPIFSQPLYNISLYENVTV 475
           PLD ET   +  +     SV DH G    KV I + + NDN P F    Y++ + EN  V
Sbjct: 92  PLDRETKSEFTVEF----SVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147

Query: 476 GTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA 535
           GT +  V ATD D G  G V Y F      F++D   G++ +I  LDYE  Q + LT+ A
Sbjct: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNA 207

Query: 536 RDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
            D        T   + I + DV D  P F    Y   + E+ P  T +  + A D+D   
Sbjct: 208 TDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR 267

Query: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ--ISNGLIYLTVMAMDAGN-- 648
              I Y+IVS +   S F +      GV++++  LD E    S+G I LTV   +  +  
Sbjct: 268 PRGIGYTIVSGNT-NSIFALDYIS--GVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323

Query: 649 PPLNSTVPVT--IEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATDLDRSREYG 705
            P ++TV  T  I V D NDN P F+   Y V++ E    G A  LF+   D D +    
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383

Query: 706 QESIIYSL-EGSTQFRINARSGE------ITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758
               +Y +   S  F I+  S +      I     LD ET   Y   + A +    H   
Sbjct: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH--- 440

Query: 759 TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVV 801
            G A V ITL++ NDN P +    Y I+L E     + V TV+
Sbjct: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483



 Score =  142 bits (357), Expect = 7e-33
 Identities = 148/472 (31%), Positives = 216/472 (45%), Gaps = 41/472 (8%)

Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
            D+ + I ED PVG  V  + A D D   N  +VF + SG  A  F  V  +   G V++ 
Sbjct: 37   DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVEPDT--GVVWLR 90

Query: 1483 RPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
            +PLDRE    + ++   SD +G   RK    + + + D+NDN P   +   Y+V + EN 
Sbjct: 91   QPLDRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQ-PYSVRIPENT 145

Query: 1542 GGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH 1601
              GT +  V ATD D+G    + Y     ++   F +D   G I T     D E    Y 
Sbjct: 146  PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARG-IVTVIRELDYETTQAYQ 202

Query: 1602 LVATVEDEG-TPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQA 1659
            L     D+  T  LS   ++ + I D  D  P+F   P+   + +  P      +IT  A
Sbjct: 203  LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT--A 260

Query: 1660 LDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE---ISHGRYTLIVTAT-- 1714
            +D D+G    + Y IV+GN  + F +D   GV+T    LD E    SHG + L V  T  
Sbjct: 261  IDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHG-FILTVKGTEL 319

Query: 1715 --DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE----GQPGPRVWTFLA 1768
              D+ P      T TTT  + V DINDN P F    E    +TE    G   P     + 
Sbjct: 320  NDDRTP---SDATVTTTFNILVIDINDNAPEF-NSSEYSVAITELAQVGFALPLFIQVVD 375

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISP--VEGV--LRVRKDVELDRETIAFYNLTICAR 1824
             D + G N   E  ++ G+    F+ISP  V+G   +R+R  + LD ET+  Y+  + A 
Sbjct: 376  KDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434

Query: 1825 DRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
            +  +P       V I +++ NDN P+      NI++ EN  V + V  VL S
Sbjct: 435  E-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485



 Score =  137 bits (345), Expect = 2e-31
 Identities = 134/478 (28%), Positives = 216/478 (45%), Gaps = 55/478 (11%)

Query: 2411 VFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF-AINPTTGDIYVLSSLDREKKD 2469
            + ED PVG+ +  + A D D  N  L+    G+  S+F A+ P TG +++   LDRE K 
Sbjct: 42   ISEDTPVGSSVTQLLAQDMD--NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
             + +     D+ G +         +V IQV DVND  P F    +S  + EN P GT + 
Sbjct: 100  EFTVEFSVSDHQGVITR-------KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152

Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGG 2587
             + ATD D G  G + YS + P  + F +D   G+VT  R L  ++ + + LTV ATD  
Sbjct: 153  IVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211

Query: 2588 EP-PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 2646
            +  PL     L + + DV D  P+F+  P  T  +I E  P  + V  + A D+D+G   
Sbjct: 212  KTRPLSTLANLAIIITDVQDMDPIFINLPYST--NIYEHSPPGTTVRIITAIDQDKGRPR 269

Query: 2647 AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV-YSLILVA-----SDLGQPV 2700
             + Y+ +  +GN +   F +D ISG++     LDRE+    +  IL       +D   P 
Sbjct: 270  GIGYTIV--SGNTN-SIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326

Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE-- 2758
                     + + DI+DN P F      S +Y  + + E +  G  +      VD DE  
Sbjct: 327  DATVTTTFNILVIDINDNAPEF-----NSSEYS-VAITELAQVGFALPLFIQVVDKDENL 380

Query: 2759 GPNAIVYYFIAAGNEEKNFHLQP-------DGCLLVLRDLDREREAIFSFIVKASSNRSW 2811
            G N++   ++  GN   +F + P       D  + V   LD E    + F + A+ +   
Sbjct: 381  GLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES--- 436

Query: 2812 TPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVL 2869
                       +   +   +V++ L + ND  P F++  Y   +  +  VG+ ++ VL
Sbjct: 437  -----------VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483



 Score =  136 bits (342), Expect = 4e-31
 Identities = 140/488 (28%), Positives = 217/488 (44%), Gaps = 51/488 (10%)

Query: 2067 PTFSPATLTVHLL--ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            P F+      +LL  E+ P G SV Q+ A D D   N  LV+ +      RF  +   TG
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
            V+ +    +DRE +  + +    +D   V    T  V I + D+ND+ P F N   +V +
Sbjct: 86   VVWL-RQPLDRETKSEFTVEFSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRI 141

Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
             E+   GT I  + A D DL         G V         P+Q   FA++   G V V 
Sbjct: 142  PENTPVGTPIFIVNATDPDLGAG------GSVLYSFQP---PSQ--FFAIDSARGIVTVI 190

Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
              ++ E    Y++T++  D     P  ++    A L + + DV D  P F       Y  
Sbjct: 191  RELDYETTQAYQLTVNATDQDKTRPLSTL----ANLAIIITDVQDMDPIFINLP---YST 243

Query: 2304 RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE 2363
             I E + PGTT+  + A+D DKG    + YT++         L D  +G +  N  +D E
Sbjct: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL-DYISGVLTLNGLLDRE 302

Query: 2364 EV---HWLNFTVRAS---DNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVP 2416
                 H    TV+ +   D+ +P  A     + + ++DINDN P F+   Y  A+ E   
Sbjct: 303  NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQ 362

Query: 2417 VG---TIILTVTATDADSGNFALIE-YSLGDGESKFAINPTTGD------IYVLSSLDRE 2466
            VG    + + V   D + G  ++ E Y +G+    F I+PT+        I V   LD E
Sbjct: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422

Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
              D Y     A ++  D          +V I +++ ND RP FS+P ++ S+YEN   GT
Sbjct: 423  TVDRYDFDLFANESVPD-----HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGT 477

Query: 2527 SVITMMAT 2534
            SV+T++ +
Sbjct: 478  SVLTVLVS 485



 Score =  135 bits (340), Expect = 7e-31
 Identities = 134/450 (29%), Positives = 208/450 (46%), Gaps = 38/450 (8%)

Query: 1313 FSNASYEAAIL--ENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV 1370
            F+N  ++  +L  E+  +G+ + ++ A  +DN + + +     +  +A   F ++  TGV
Sbjct: 31   FTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN-DPLVF---GVSGEEASRFFAVEPDTGV 86

Query: 1371 ITVQGLVDRE-KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIP 1429
            + ++  +DRE K +F     V+D  G     T KV I V D NDN+P F      +V IP
Sbjct: 87   VWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFH-NQPYSVRIP 142

Query: 1430 EDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREE 1489
            E+ PVG  +  V A DPD G+ G V++S    +     +    + + G V V R LD E 
Sbjct: 143  ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-----QFFAIDSARGIVTVIRELDYET 197

Query: 1490 LDHYILQVVASDRG-TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVV 1548
               Y L V A+D+  T P      L + I D+ D  P+  +   Y+ ++ E+   GT V 
Sbjct: 198  TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN-LPYSTNIYEHSPPGTTVR 256

Query: 1549 QVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH-LVATVE 1607
             + A D+D G    + Y I  GN +  F +D ISG + T     DRE   + H  + TV+
Sbjct: 257  IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISG-VLTLNGLLDRENPLYSHGFILTVK 315

Query: 1608 -----DEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALD 1661
                 D+ TP+  + TT   + ++D NDNAP F    Y V + E         + IQ +D
Sbjct: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375

Query: 1662 LDE--GPNGTVTYAIVAGN----IVNTFRIDRHMGV-ITAAKELDYEISHGRYTLIVTAT 1714
             DE  G N      +V  N    I++   +     + I  A  LDYE +  RY   + A 
Sbjct: 376  KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE-TVDRYDFDLFAN 434

Query: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
            +  P   H       V + + + NDN P F
Sbjct: 435  ESVP--DH--VGYAKVKITLINENDNRPIF 460



 Score =  122 bits (307), Expect = 5e-27
 Identities = 130/463 (28%), Positives = 197/463 (42%), Gaps = 47/463 (10%)

Query: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETT 1063
            +SED P    V  L   D D   N  L + ++G      F+V     VV     LDRET 
Sbjct: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98

Query: 1064 AAYMLILEAIDNGPVGKRHTGTAT--VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
            + + +     D       H G  T  V + V DVNDN P F    Y   +PE+ P G  I
Sbjct: 99   SEFTVEFSVSD-------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151

Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
              + ATD D G  G V Y     +    F I  + G ++   R LD E   ++ L V A 
Sbjct: 152  FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARG-IVTVIRELDYETTQAYQLTVNAT 208

Query: 1182 NHD-LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
            + D   P+ +   + + + D+ D  P+F    YS   + E +  GT+V ++ A D+D G 
Sbjct: 209  DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS-TNIYEHSPPGTTVRIITAIDQDKGR 267

Query: 1241 GGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYET---KTSYMMNVSAT----DQAPPF 1292
               + Y I+SG     F +D  +G++     LD E       +++ V  T    D+ P  
Sbjct: 268  PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327

Query: 1293 NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI-VRVQAYSIDNLNQITYRFN 1351
                 +  I +++  D A +F+++ Y  AI E   +G  + + +Q    D    +   F 
Sbjct: 328  ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387

Query: 1352 AY-------------TSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKV 1398
             Y             TS Q KA  +       I V   +D E  D Y   + A++  P  
Sbjct: 388  VYLVGNNSHHFIISPTSVQGKADIR-------IRVAIPLDYETVDRYDFDLFANESVPDH 440

Query: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV 1441
                KV IT+++ENDN P F     + +S+ E+  VG  V TV
Sbjct: 441  VGYAKVKITLINENDNRPIFSQPLYN-ISLYENVTVGTSVLTV 482



 Score =  121 bits (304), Expect = 1e-26
 Identities = 136/478 (28%), Positives = 203/478 (42%), Gaps = 50/478 (10%)

Query: 1206 PVFTQQQYSR-LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-----FEID 1259
            P FT   +   L + E   +G+SV  + A D D       N  ++ G  G+     F ++
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-------NDPLVFGVSGEEASRFFAVE 81

Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319
              TG++     LD ETK+ + +  S +D      +    V I + +  D A  F N  Y 
Sbjct: 82   PDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS 138

Query: 1320 AAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLV 1377
              I EN  +GT I  V A   D      + Y F   +       F ID+  G++TV   +
Sbjct: 139  VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-----FFAIDSARGIVTVIREL 193

Query: 1378 DREKGDFYTLTVVADDGGPK--VDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG 1435
            D E    Y LTV A D      + +   + I + D  D  P F      + +I E  P G
Sbjct: 194  DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPG 252

Query: 1436 QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPL-DREE--LDH 1492
              V  + A D D G    + +++ SGN    F +    D I  V     L DRE     H
Sbjct: 253  TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL----DYISGVLTLNGLLDRENPLYSH 308

Query: 1493 -YILQVVASDRGTPPRKKDHILQVT----ILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
             +IL V  ++        D  +  T    ++DINDN P   S   Y+V++ E    G A+
Sbjct: 309  GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSS-EYSVAITELAQVGFAL 367

Query: 1548 ---VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRIS----GEIATRPAPP-DRERQSF 1599
               +QV   D ++G+NS+   Y+  GN    F +   S     +I  R A P D E    
Sbjct: 368  PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426

Query: 1600 YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITI 1657
            Y       +E  P       V +T+++ENDN P+F QP Y + L E   T+ TS++T+
Sbjct: 427  YDF-DLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV-TVGTSVLTV 482



 Score =  120 bits (300), Expect = 3e-26
 Identities = 110/368 (29%), Positives = 161/368 (43%), Gaps = 28/368 (7%)

Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
            V +++ D+NDN P F    Y   + E+ PVGT I  V ATD D G    + YS       
Sbjct: 118  VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF 177

Query: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
            FAI+   G + V+  LD E    Y LT  A D      +        + I + DV D  P
Sbjct: 178  FAIDSARGIVTVIRELDYETTQAYQLTVNATDQD---KTRPLSTLANLAIIITDVQDMDP 234

Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVT 2566
             F    +ST++YE+ P GT+V  + A DQD+G    + Y++  G     F +D  SG++T
Sbjct: 235  IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294

Query: 2567 ------TQRPLQSYEKFSLTVVAT----DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
                   + PL S+  F LTV  T    D        TT   + VID+NDN P F     
Sbjct: 295  LNGLLDRENPLYSH-GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353

Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG----- 2671
               +    ++     ++ +   DKDE L     +       N     FII P S      
Sbjct: 354  SVAITELAQVGFALPLF-IQVVDKDENLGLNSMFEVYLVGNNS--HHFIISPTSVQGKAD 410

Query: 2672 -LIQTAQRLDRESQAVYSLILVASDLGQPVP-YETMQPLQVALEDIDDNEPLFVRPPKGS 2729
              I+ A  LD E+   Y   L A+   + VP +     +++ L + +DN P+F +P    
Sbjct: 411  IRIRVAIPLDYETVDRYDFDLFAN---ESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467

Query: 2730 PQYQLLTV 2737
              Y+ +TV
Sbjct: 468  SLYENVTV 475



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 93/429 (21%), Positives = 169/429 (39%), Gaps = 66/429 (15%)

Query: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
            P F      T L I E+ P+ S+V ++ A D D   N  + +     +G     FF ++P
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFG---VSGEEASRFFAVEP 82

Query: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
             +G++   Q LDRE+++ +++    SD    +     + + + + D++DN P F   P  
Sbjct: 83   DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT----RKVNIQVGDVNDNAPTFHNQPYS 138

Query: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVL 2788
                  + +PE++P GT +  +  A D D G    V Y     ++         G + V+
Sbjct: 139  ------VRIPENTPVGTPIF-IVNATDPDLGAGGSVLYSFQPPSQFFAID-SARGIVTVI 190

Query: 2789 RDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK 2848
            R+LD E    +   V A+      P              TL  + +++ D+ D  P F  
Sbjct: 191  RELDYETTQAYQLTVNATDQDKTRPLS------------TLANLAIIITDVQDMDPIFIN 238

Query: 2849 AEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMG 2908
              Y+  +   +  G+ +  + A+D D G    + Y+I+           S +   +F + 
Sbjct: 239  LPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-----------SGNTNSIFALD 287

Query: 2909 SMDGILRTFDLFMAYSPGY---FVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIP 2965
             + G+L    L    +P Y   F++ +   +L   ND           D  V    N + 
Sbjct: 288  YISGVLTLNGLLDRENPLYSHGFILTVKGTEL---NDDR------TPSDATVTTTFNILV 338

Query: 2966 DRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
              +     EF            N+      + +  +V FA   L I VV++D N  L+  
Sbjct: 339  IDINDNAPEF------------NSSEYSVAITELAQVGFA-LPLFIQVVDKDENLGLNSM 385

Query: 3026 RVIQMIDEN 3034
              + ++  N
Sbjct: 386  FEVYLVGNN 394


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  922 bits (2383), Expect = 0.0
 Identities = 832/2834 (29%), Positives = 1281/2834 (45%), Gaps = 228/2834 (8%)

Query: 40   LLISEDTPVGSSVTQLLAQDMDNDPLV---FGVSGEEASRFFAVEPDTGVVWLRQP---- 92
            L + E T  G+      A+D D   L    + +SG+ A   F +E   G      P    
Sbjct: 150  LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209

Query: 93   ---LDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
               LDRE +S + ++    D      R    +++ + D+ND+AP F+   Y   + E+  
Sbjct: 210  TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269

Query: 147  VGTPIFIVNATDPDLGAGGSVLYSFQPPSQF----FAIDSARGIVTVIRELDYETTQAYQ 202
             G+P+  V A+D D G  G+V Y            F+ID+  G++ + R LD+E  + ++
Sbjct: 270  PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329

Query: 203  LTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNIYEHSPPGTTVRII 258
            L V A D      L + A + + + D  D  P    IF++   S  + E +PPG  V  I
Sbjct: 330  LVVQARDGGAHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARI 388

Query: 259  TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
            +  D D G    +  ++  G  +  FAL     V+ L  +  R +      + L V  T+
Sbjct: 389  SVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
                   ++A     F + V D+NDNAP F+   Y      L +V       ++V  +D 
Sbjct: 447  SGSPPLRAEA----AFVLHVTDVNDNAPAFDRQLYRP--EPLPEVALPGSFVVRVTARDP 500

Query: 379  NLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
            + G N      L  G ++H F I PTS        I  A  LDYE   +    + A +  
Sbjct: 501  DQGTNGQVTYSLAPGAHTHWFSIDPTSG------IITTAASLDYELEPQPQLIVVATDGG 554

Query: 437  VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVS 496
            +P     A V + L + NDN P F +  YN SL E    GT  L V ATD D+G FG +S
Sbjct: 555  LPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLS 614

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRIN 550
            Y       S     F +D  +G +     LD +     F  T+ A DGGG ++   V++ 
Sbjct: 615  YSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVF 674

Query: 551  VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
            + D NDN P F    Y  ++    P  T ++RLRA D D   + +++Y I++ ++   + 
Sbjct: 675  LSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLF- 733

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
              +L E  G+++V+ PL   + +N ++ L + A D G      +  V I +      PP 
Sbjct: 734  --TLDEQSGLLTVAWPL--ARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789

Query: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGE 727
            F +  Y  SV E++  G +V  + A     +       +  SL G      F ++A SG 
Sbjct: 790  FEQLQYVFSVPEDVAPGTSVGIVQA----HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845

Query: 728  ITTTSLLDRETKSEYI-LIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
            + T   LDRE     + L VRA   G G      +A V + L D+NDN P +      + 
Sbjct: 846  LQTLRPLDRELLGPVLELEVRA---GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVL 902

Query: 787  LVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENP 845
            L   T P + + T+ A+DPD G N  + ++ +      ++++ TTG +R    +     P
Sbjct: 903  LPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGP 962

Query: 846  DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
              HE EL         D G PP  +     V V  +      P F +  +  ++  G  A
Sbjct: 963  -AHELEL------EARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTA 1015

Query: 906  GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
            G  + QV A   D    G ++Y +        F +   SG +     LDRE    Y L+V
Sbjct: 1016 GTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKV 1072

Query: 966  VA---SDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
            +A   S A    ++ T+T+ + +L+ N+ +P        ++V+E+ P    V  +  TD 
Sbjct: 1073 MAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR 1132

Query: 1023 DVGLNAELSYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKR 1081
            D G N  L+Y +   + D K F +  +   V T+  LDRE  ++Y L+++  D G   + 
Sbjct: 1133 DSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRS 1192

Query: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEA------SVPEDIPEGHSILQLKATDADEGEFG 1135
             TG  TV V VLD+NDN P FLQ+S  A       VP+ +P G  +  L+A D DEGE G
Sbjct: 1193 TTG--TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENG 1250

Query: 1136 RVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI 1195
             + Y  L G     F +H  +G L+    PL R     +VL + A++    P  +S++++
Sbjct: 1251 TILY-TLTGPGSELFSLHPHSGELLTA-APLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308

Query: 1196 VYV---EDINDEAPVFTQQQYSR-----LGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
            V V     + +  P   ++  +      L +    G+    ++      +    G + Y 
Sbjct: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYT 1368

Query: 1248 ILSGA--EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLN 1305
            ++ GA  EG F +D ++G +     LD+E    +       +           V + + +
Sbjct: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQD 1428

Query: 1306 ELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKI 1364
            E + A  F+      A+ EN   G  +   +A   D        R+            ++
Sbjct: 1429 ENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRL 1488

Query: 1365 DAITGVITVQGLVDREKGDFYTLTVVADD----GGPKVDSTVKVYITVLDENDNSPRFDF 1420
            DA TG ++    +DRE      L V A D       +  + V   + V DENDN+P   F
Sbjct: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP--VF 1546

Query: 1421 TSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVF 1480
             S S V +PED P G     V A DPD G   +V + LASG   G F +   + S G + 
Sbjct: 1547 ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRL---HSSTGALS 1602

Query: 1481 VARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNEN 1540
            V RPLDRE+   ++L VVASD G+PPR    +L V++ D+ND  P  +    Y+V + EN
Sbjct: 1603 VVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQ-EYSVLLREN 1661

Query: 1541 VGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFY 1600
               GT+++ +RATD D+G N  ++Y    G    +F +D  +G + T  A  DRE Q   
Sbjct: 1662 NPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA-LDREEQEEI 1717

Query: 1601 HLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQAL 1660
            +L    +D G+P       V V + DEND+AP F   H  + + EG D    +L  ++A 
Sbjct: 1718 NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP--QTLTMLRAS 1775

Query: 1661 DLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
            D D G NG + Y I+ G+    F +D   G     + LD E+       I       P L
Sbjct: 1776 DPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPAL 1835

Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQV 1779
            S  L  T TVL    D ND+ P FP       EV E  P G  +    AHD D+G NG V
Sbjct: 1836 SATLLLTVTVL----DANDHAPAFPVPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHV 1890

Query: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD-RGMPPLSSTMLVG 1838
             Y +  G   G F++ P  G LR      LDRE    Y  ++ A D     PLS+T+ V 
Sbjct: 1891 TYYLGAG-TAGAFLLEPSSGELRTA--AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVT 1947

Query: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSS----FVAHVLASDADSGCNARLTFNITAGN 1894
            I V D+ND+ P     P+ + +    P  S     +A + A D D+G NA + + + AG 
Sbjct: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGT 2006

Query: 1895 RERAFFINATTGIVTVNR-PL---DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
                  +++ TG + V R P+    R+R+    L I   D     R AR    ++++ L 
Sbjct: 2007 PPPGTTVDSYTGEIRVARSPVALGPRDRV----LFIVATD---LGRPARSATGVIIVGLQ 2059

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV--------LNGPILALDADQDIYAVVTYQL 2002
             E +  P F +++ +A + EN+P GTP+           NGPI             TY +
Sbjct: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPI-------------TYSI 2106

Query: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061
            L G + G F I  STG +TVRS   +D E    P L L+L AE  G    T  L +T+ D
Sbjct: 2107 LSGNEKGTFSIQPSTGAITVRSAEGLDFEV--SPRLRLVLQAESGGAFAFTV-LTLTLQD 2163

Query: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHL- 2120
             NDN P F        L E+ P    +LQV A D D G  G++ Y + A    R L H+ 
Sbjct: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVD 2223

Query: 2121 -VTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
              TG I    A +DRE     RL ++ATDRG+  L G+A +T+++ D ND+RP    P +
Sbjct: 2224 PTTGTITT-TAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWE 2282

Query: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
             + V E A  G+ IA +T  D D  P L Y +                +D F+V    G 
Sbjct: 2283 -LRVSEDALLGSEIAQVTGNDVDSGPVLWYVL-----------SPSGPQDPFSVGRYGGR 2330

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            V +  P++ E    Y++ L   D   +          A LTV V DVNDN P F     +
Sbjct: 2331 VSLTGPLDFEQCDRYQLQLLAHDGPHE--------GRANLTVLVEDVNDNAPAFSQ---S 2379

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
             Y   +LE   PG+ +++V+A D D G NG ++Y L        V   + +   ++    
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVA 2439

Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
            + ++    ++  + A D+G+P RAA   V++++ D ND+ P F    Y+ AV ED+P G+
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499

Query: 2420 IILTVTATDAD-SGNFALIEYSL--GDGESKFAINP--------------TTGDIYVLSS 2462
             +LT+ ATDAD S + A ++YS+  G+    F + P                G + +L  
Sbjct: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
            LD E    Y LT  A D         + + V V + VLDVND  P F++  +  +V E+ 
Sbjct: 2560 LDFESLTQYNLTVAAADR----GQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615

Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
            P G  ++ + A+D D GP+G + +++  G     F +D  SG +     L  ++  +  L
Sbjct: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
             V A D      +    + +EV DVND+ P F  P N     + E  P  + V  ++A D
Sbjct: 2676 VVQAADPAGAH-FALAPVTIEVQDVNDHGPAF--PLNLLSTSVAENQPPGTLVTTLHAID 2732

Query: 2640 KDEGLNGAVRYSFLKTA-GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
             D G  G +RYS L+   G    E F ++  +G ++     D E    + L++ A+D G 
Sbjct: 2733 GDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN 2792

Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
                     + V +   D+ +P+F+ P   +  +Q   VPE + RG  +G+V  A D D 
Sbjct: 2793 ---LSASVTVSVLVTGEDEYDPVFLAP---AFHFQ---VPEGARRGHSLGHVQ-ATDEDG 2842

Query: 2759 GPNAIVYYFIAAGN 2772
            G + +V Y +A  +
Sbjct: 2843 GADGLVLYSLATSS 2856



 Score =  831 bits (2147), Expect = 0.0
 Identities = 838/2969 (28%), Positives = 1298/2969 (43%), Gaps = 254/2969 (8%)

Query: 18   ISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEAS 75
            + G WGQ   L           L I E+ P G+ +  + A        PL++ +S +E S
Sbjct: 37   VPGAWGQAGSLD----------LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGS 86

Query: 76   RF---FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
                  A++  +GVV   + LDRE +  +   F+     G  T +V ++V D+ND+AP F
Sbjct: 87   GVGTDLAIDEHSGVVRTARVLDREQRDRY--RFTAVTPDGA-TVEVTVRVADINDHAPAF 143

Query: 133  HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQFFAIDSARG----- 185
                 ++++PE+T  GT   +  A D D G  G+  Y  S     + F +++  G     
Sbjct: 144  PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTP 203

Query: 186  --IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 243
               + V  ELD E    Y L + A D   + P    A L + + D+ D  P F    Y  
Sbjct: 204  VPELVVTGELDRENRSHYMLQLEAYD-GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 262

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNTNSIFALDYISGVLTLNGLLDR 301
             + E   PG+ V  + A D D G    + Y I       +  F++D  +G+L L   LD 
Sbjct: 263  VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDF 322

Query: 302  ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE----FNSSEYSVAI 357
            E         L V+  +         A VT    + V D NDN P     F S++ S  +
Sbjct: 323  EQRRVHE---LVVQARDGGAHPELGSAFVT----VHVRDANDNQPSMTVIFLSADGSPQV 375

Query: 358  TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAI 417
            +E A  G  L   I V D D+  G  +   V L G   H  +    S Q      + VA 
Sbjct: 376  SEAAPPG-QLVARISVSDPDD--GDFAHVNVSLEGGEGHFAL----STQDSVIYLVCVAR 428

Query: 418  PLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNIS-LYENVTV 475
             LD E  D Y+  + A +S  P     A   + + + NDN P F + LY    L E    
Sbjct: 429  RLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP 488

Query: 476  GTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTI 533
            G+ V+ V A D D GT G+V+Y  +       FS+D  +G+I   A LDYEL  +  L +
Sbjct: 489  GSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIV 548

Query: 534  IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 591
            +A DGG     ++  V + + DVNDN P FQ+  Y  +L E     T  +++ ATD DS 
Sbjct: 549  VATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG 608

Query: 592  PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 651
            P   ++YS+ +           +    G +  +R LD +Q  +   + TV A+D G   L
Sbjct: 609  PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF-TVTAVDGGG--L 665

Query: 652  NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIY 711
             S V V + + DENDNPP F    Y  S+      G  VL L A D D+         I 
Sbjct: 666  KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHIL 725

Query: 712  SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771
            +      F ++ +SG +T    L R   S   L + A DG  G  Q    A V+I+++  
Sbjct: 726  AGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDG--GGLQAEPSARVDISIVPG 783

Query: 772  NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
                P ++   Y  ++ E   P + V  V A +P  G    +  S+    P   +SL++ 
Sbjct: 784  TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAV 842

Query: 830  TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
            +G ++T           P + EL+  ++      G     A + A V V L D+NDN P 
Sbjct: 843  SGLLQTLR---------PLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPA 893

Query: 890  FQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVT 949
            F        +      G  IY + A+D D G+N  V++ +  G     F ++ ++G V  
Sbjct: 894  FPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRL 952

Query: 950  TTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE--TPTFFPAVYNVSVSED 1007
               L       ++L + A D G+P ++S   L + V DV      P F    Y V +   
Sbjct: 953  MRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSG 1012

Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
                 +V+ +     D G    ++Y +        F +  +   +     LDRE    Y+
Sbjct: 1013 TTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069

Query: 1068 LILEAIDNGPVG-KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
            L + A+        + TGTATV V++L+ N++ P   +     +V E+ P G S+ ++ A
Sbjct: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFA 1129

Query: 1127 TDADEGEFGRVWYRILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
            TD D G  GR+ Y +         FRIH   G +    + LDRE+ SS+ L+V+  +   
Sbjct: 1130 TDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTT-LQTLDREQQSSYQLLVQVQDGGS 1188

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLG-----LRETAGIGTSVIVVQATDRDSGD 1240
             P  ++  V V V D+ND +P F Q   +  G     + +    GT V  +QA D D G+
Sbjct: 1189 PPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE 1248

Query: 1241 GGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVY 1300
             G + Y +       F +   +G ++T   L    +  Y++ +SA DQ  P       + 
Sbjct: 1249 NGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308

Query: 1301 ITLLNEL------DEAVQFSNASYEAAIL-----ENLALGTEIVRVQAYSIDNLNQITYR 1349
            + +L          +  +   A+    +L     E L  G+ +  V A     +  +TY 
Sbjct: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTY- 1367

Query: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKG-DFYTLTVVADDGGPKVDSTVKVYITV 1408
                     +  F +DA +G + +   +D E G  +  LTV A+  G      ++V + V
Sbjct: 1368 -TLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQV 1426

Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDA-GSNGQVVFSLASGNIAGAF 1467
             DEN+++P F      A+++PE+   G  + T +A D D  G N  V + L         
Sbjct: 1427 QDENEHAPAF-ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE--PPV 1483

Query: 1468 EIVTTNDSIGEVFVARPLDREELDHYILQVVASDR---GTPPRKKDHILQVTILDINDNP 1524
              +  +   G +   R LDRE     +L V A+DR    +  R      +V + D NDN 
Sbjct: 1484 PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNA 1543

Query: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
            PV  SP    V + E+   G A + V A D D+G  + +SY +  G  D  FR+   +G 
Sbjct: 1544 PVFASP--SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGA 1600

Query: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD 1644
            ++    P DRE+++ + L     D G+P  SAT  + V++ D ND AP FQQ  Y VLL 
Sbjct: 1601 LSV-VRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659

Query: 1645 EGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISH 1704
            E  +   TSL+T++A D D G NG VTY  V+     +F +D   GV+T  + LD E   
Sbjct: 1660 EN-NPPGTSLLTLRATDPDVGANGQVTYGGVSS---ESFSLDPDTGVLTTLRALDRE-EQ 1714

Query: 1705 GRYTLIVTATDQ--CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
                L V A D+   P L+H      TV V V D ND+ PTF   +    EV EGQ    
Sbjct: 1715 EEINLTVYAQDRGSPPQLTH-----VTVRVAVEDENDHAPTFGSAHLS-LEVPEGQDPQT 1768

Query: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1822
            +    A D D G NGQ++Y I+DGDP G FV+    G     +   LDRE    + L I 
Sbjct: 1769 LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR--PLDREVEPAFQLRIE 1826

Query: 1823 ARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
            ARD G P LS+T+L+ + VLD ND+ P       ++ + E+ P  + +  + A D D+G 
Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA 1886

Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
            N  +T+ + AG    AF +  ++G +     LDRE+ P Y  ++S  D      ++    
Sbjct: 1887 NGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT-- 1943

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
              + I + D ND+ P F  S  +  +    P+ +  T+    + A D D    A + Y+L
Sbjct: 1944 VSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003

Query: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITIL 2060
             G       ++S TG + V    +    A  P    L ++A D+G    ++T  +++ + 
Sbjct: 2004 AGTPPPGTTVDSYTGEIRVARSPV----ALGPRDRVLFIVATDLGRPARSATGVIIVGLQ 2059

Query: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIH 2119
             + +  P F  A+    + EN PPG  ++   A     G NG + Y I +G  +  F I 
Sbjct: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQ 2118

Query: 2120 LVTGVIRVGNAT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
              TG I V +A  +D E     RL + A   G    +   ++T+ + D ND+ P FL P 
Sbjct: 2119 PSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPH 2175

Query: 2179 QTVSVLESAEPGTVIANITA--IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236
                + ES      +  + A  +D     ++ Y    + A      L       F V+  
Sbjct: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISY---SLAASQPARGL-------FHVDPT 2225

Query: 2237 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF-KP 2295
            TG++   + ++RE+ A   + L   D  S        V +A LTV V+D NDN P   +P
Sbjct: 2226 TGTITTTAILDREIWAETRLVLMATDRGS-----PALVGSATLTVMVIDTNDNRPTIPQP 2280

Query: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
            + +     R+ E A  G+ +  V   D D   +G V + +L    P          G+V 
Sbjct: 2281 WEL-----RVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVS 2332

Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
                +D+E+       + A D G     A + V +E  D+NDN P F Q  YQ  + E  
Sbjct: 2333 LTGPLDFEQCDRYQLQLLAHD-GPHEGRANLTVLVE--DVNDNAPAFSQSLYQVMLLEHT 2389

Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
            P G+ IL+V+ATD DSG    I Y L      F+++P  G ++ +              A
Sbjct: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVG----------TVA 2439

Query: 2476 LAKDNPG--DVASNRRENS-------VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
            L  D  G  DV    R++          V +Q+ D ND  P F+   +  +V E+ P G+
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499

Query: 2527 SVITMMATDQD-EGPNGELTYSL---------------------EGPGVEAFHVDMDSGL 2564
            +++T+ ATD D    +  + YS+                      GPG  A       G 
Sbjct: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRAL------GC 2553

Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622
            +    PL  +S  +++LTV A D G+PP      + V V+DVNDN PVF R      + +
Sbjct: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA--SYRVTV 2611

Query: 2623 REEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRE 2682
             E+ P+ + +  V A+D D G +G VR++    +       F +D  SG ++ A  LD E
Sbjct: 2612 PEDTPVGAELLHVEASDADPGPHGLVRFT---VSSGDPSGLFELDESSGTLRLAHALDCE 2668

Query: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT-VPEHS 2741
            +QA + L++ A+D      +  + P+ + ++D++D+ P F       P   L T V E+ 
Sbjct: 2669 TQARHQLVVQAAD--PAGAHFALAPVTIEVQDVNDHGPAF-------PLNLLSTSVAENQ 2719

Query: 2742 PRGTLVGNVTGAVDADEGP-NAIVYYFIAAG---NEEKNFHLQPD-GCLLVLRDLDRERE 2796
            P GTLV     A+D D G    + Y  + AG      + F L    G L      D E  
Sbjct: 2720 PPGTLV-TTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHT 2778

Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
              F  +V            G +   +L A +T   V V++   ++  P F    +   V 
Sbjct: 2779 ESFRLLV------------GAADAGNLSASVT---VSVLVTGEDEYDPVFLAPAFHFQVP 2823

Query: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSI 2885
              A+ G  L  V A D D G + LV YS+
Sbjct: 2824 EGARRGHSLGHVQATDEDGGADGLVLYSL 2852



 Score =  816 bits (2107), Expect = 0.0
 Identities = 810/2782 (29%), Positives = 1226/2782 (44%), Gaps = 283/2782 (10%)

Query: 245  IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-------SGNTNSIFALDYISGVLTLNG 297
            I E  P GT +  I+A     G P G    ++            +  A+D  SGV+    
Sbjct: 51   IDEEQPAGTLIGDISA-----GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105

Query: 298  LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 357
            +LDRE       +  T          TP  ATV  T  + V DIND+AP F  +  ++ +
Sbjct: 106  VLDREQ---RDRYRFTAV--------TPDGATVEVT--VRVADINDHAPAFPQARAALQV 152

Query: 358  TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT--SVQGKADIRIRV 415
             E    G   PL      +D + G        L G+ +       T     G     + V
Sbjct: 153  PEHTAFGTRYPL---EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209

Query: 416  AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
               LD E    Y   L A +   P     A + +TL++ ND+ P F+Q  Y+  + E++ 
Sbjct: 210  TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269

Query: 475  VGTSVLTVLATDNDAGTFGEVSYFF----SDDPDRFSLDKDTGLIMLIARLDYELIQRFT 530
             G+ VL V A+D DAG  G V+Y      S+    FS+D  TGL+ L   LD+E  +   
Sbjct: 270  PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329

Query: 531  LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ-------LV 581
            L + ARDGG     G   V ++V D NDN P+      +    +  P V++       + 
Sbjct: 330  LVVQARDGGAHPELGSAFVTVHVRDANDNQPSM---TVIFLSADGSPQVSEAAPPGQLVA 386

Query: 582  RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY-GVISVSRPLDYEQISNGLIYLT 640
            R+  +D   P +    +  VS      +F +S  +    ++ V+R LD E+       L 
Sbjct: 387  RISVSD---PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREE--RDAYNLR 441

Query: 641  VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI-MAGATVLFLNATDLD 699
            V A D+G+PPL +     + V D NDN P F +  Y    +  + + G+ V+ + A D D
Sbjct: 442  VTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPD 501

Query: 700  RSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
            +    GQ  + YSL        F I+  SG ITT + LD E + +  LIV A DGG+   
Sbjct: 502  QGTN-GQ--VTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPL 558

Query: 757  QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
              +  ATV++ L D+NDN P ++   Y  +L E T P +    V A D D G  G L YS
Sbjct: 559  ASS--ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYS 616

Query: 817  I--------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
            +         PP   + +++ +G + TT  +   + P   +        V+  D G   L
Sbjct: 617  LGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQGPSSFD------FTVTAVDGGG--L 665

Query: 869  KATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYR 928
            K+     VF++  D NDN P F    + A +    P G ++ ++ A D D+G +G +SY 
Sbjct: 666  KSMVYVKVFLS--DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723

Query: 929  MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 988
            +  G     F ++  SG++     L R   +  QL + A D G      ++ + I ++  
Sbjct: 724  ILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPG 783

Query: 989  NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYR 1048
                P F    Y  SV EDV     V  +    N  G  A ++  ++GG+  G FS+   
Sbjct: 784  TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSLDAV 842

Query: 1049 DAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYE 1108
              +++T+  LDRE     +L LE      V       A V V + DVNDN P F      
Sbjct: 843  SGLLQTLRPLDRELLGP-VLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPEDT 900

Query: 1109 ASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR 1168
              +P +   G  I  L+A D D G   RV + +L G  G  F +  + G + R  RPL  
Sbjct: 901  VLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHV-RLMRPLGP 958

Query: 1169 ERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE--APVFTQQQYSRLGLRETAGIGT 1226
                +H L +EA +    P  S  R+ V V+D+     AP F    Y R+ L      GT
Sbjct: 959  SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTY-RVDLPSGTTAGT 1017

Query: 1227 SVIVVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA 1285
             V+ VQA    + DGG + Y + + GA   F ++  +G +     LD E +  Y++ V A
Sbjct: 1018 QVLQVQA---QAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1074

Query: 1286 TDQAPPF---NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
               +        G  +V +++LN+ + + + S      A+ EN   GT + RV A   D+
Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134

Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDST 1401
                   ++    ++    F+I   TG +T    +DRE+   Y L V   DGG P   +T
Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTT 1194

Query: 1402 VKVYITVLDENDNSPRFDFTSDSA-----VSIPEDCPVGQRVATVKAWDPDAGSNGQVVF 1456
              V++ VLD NDNSP F   S +A     + +P+  P G  V T++A DPD G NG +++
Sbjct: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILY 1254

Query: 1457 SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
            +L         E+ + +   GE+  A PL R E  HY+L + A D+G+PPR     L V 
Sbjct: 1255 TLTGPGS----ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQ 1310

Query: 1517 IL----------DINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY 1566
            +L          D+ +  P    P    V+  E +  G+ +  V A +   G+ ++    
Sbjct: 1311 VLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-PAGVGALTYTL 1369

Query: 1567 ITEGNKDMAFRMDRISGEI-ATRP-----APPDRERQSFYHLVATVEDEGTPTLSATT-H 1619
            +   + +  F +D  SG +   RP      PP R          TV  EG     A    
Sbjct: 1370 VGGADPEGTFALDAASGRLYLARPLDFEAGPPWR--------ALTVRAEGPGGAGARLLR 1421

Query: 1620 VYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-EGPNGTVTYAIVAGN 1678
            V V + DEN++AP F +    + L E P+    +L T +A D D  GPN  V Y ++   
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEP-GAALYTFRASDADGPGPNSDVRYRLLRQE 1480

Query: 1679 I-VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDI 1737
              V   R+D   G ++A + LD E +     L+V ATD+    S R  +  +  V V D 
Sbjct: 1481 PPVPALRLDARTGALSAPRGLDRETTPA-LLLLVEATDRPANASRRRAARVSARVFVTDE 1539

Query: 1738 NDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISP 1796
            NDN P F         + E QP GP     +A D D G   +V Y +  G   G F +  
Sbjct: 1540 NDNAPVFASPSR--VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHS 1596

Query: 1797 VEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPM 1856
              G L V +   LDRE  A + LT+ A D G PP S+T ++ + V D+ND  P       
Sbjct: 1597 STGALSVVRP--LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEY 1654

Query: 1857 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDR 1916
            ++ + EN+P  + +  + A+D D G N ++T+    G    +F ++  TG++T  R LDR
Sbjct: 1655 SVLLRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDR 1711

Query: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
            E   E  LT+  +D    P++    +  + + + DEND+ P F  +    EV E     T
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQLT---HVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768

Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVV-TVRSGVIIDREAFSP 2034
             LT+L     A D D      + Y++L G  SG F ++ ++G   T+R    +DRE    
Sbjct: 1769 -LTMLR----ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRP---LDREV--E 1818

Query: 2035 PILELLLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVT 2092
            P  +L + A D G   L++T  L +T+LD ND+ P F     +V + E+ P G  +LQ+ 
Sbjct: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878

Query: 2093 ATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV 2152
            A D D+G NG + Y + AG    FL+   +G +R   A +DRE+  SY  +V A D    
Sbjct: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTA-AALDREQCPSYTFSVSAVDGAAA 1937

Query: 2153 -PLSGTAIVTILIDDINDSRPEF-LNPIQTVSVLESAEPGT-------VIANITAIDHDL 2203
             PLS T  VTI + D+ND  P F  +P++    L    PG         +A + A D D 
Sbjct: 1938 GPLSTTVSVTITVRDVNDHAPTFPTSPLR----LRLPRPGPSFSTPTLALATLRAEDRDA 1993

Query: 2204 --NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV-KSPMNRELVATYEVTLSV 2260
              N  + Y + G      T            V+  TG + V +SP+    +   +  L +
Sbjct: 1994 GANASILYRLAGTPPPGTT------------VDSYTGEIRVARSPV---ALGPRDRVLFI 2038

Query: 2261 IDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAA 2320
            +      P RS +     + V +    +  P+F           I E A PGT +++  A
Sbjct: 2039 VATDLGRPARSAT---GVIIVGLQGEAERGPRFPRASSE---ATIRENAPPGTPIVSPRA 2092

Query: 2321 VDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT-VDYEEVHWLNFTVRASDNGS 2379
            V    G NG +TY++L     G   ++ S+    + +   +D+E    L   ++A   G+
Sbjct: 2093 VHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA 2151

Query: 2380 PPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEY 2439
                A   + L + D NDN P F +P Y   + E  P+   +L V A D D G+   I Y
Sbjct: 2152 ---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208

Query: 2440 SLGDGESK---FAINPTTGDIYVLSSLDRE--KKDHYILTALAKDNPGDVASNRRENSVQ 2494
            SL   +     F ++PTTG I   + LDRE   +   +L A  + +P  V S        
Sbjct: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS------AT 2262

Query: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE 2554
            + + V+D ND RP   +P +   V E+   G+ +  +   D D GP      S  GP  +
Sbjct: 2263 LTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQ-D 2320

Query: 2555 AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
             F V    G V+   PL  +  +++ L ++A DG   P  G   L V V DVNDN P F 
Sbjct: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFS 2377

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
            +     +L   E  P  S +  V ATD+D G NG + Y     A       F +DP +G 
Sbjct: 2378 QSLYQVML--LEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDPNNGT 2430

Query: 2673 IQT---AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2729
            + T      L  +      ++L A D G P        + V L+D +D+ P F       
Sbjct: 2431 LFTIVGTVALGHDGSGAVDVVLEARDHGAP-GRAARATVHVQLQDQNDHAPSFTLS---- 2485

Query: 2730 PQYQLLTVPEHSPRGTLVGNVTGAVDADEG-PNAIVYYFIAAGNEEKNFHLQPD------ 2782
              Y++    +  P  TL+     A DAD    +A V Y I +GN  + F L+P       
Sbjct: 2486 -HYRVAVTEDLPPGSTLL--TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542

Query: 2783 ---------GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVR 2833
                     GCL++L  LD E    ++  V A+        RG  P   +V       V 
Sbjct: 2543 SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD-------RGQPPQSSVVP------VT 2589

Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRA 2893
            V + D+ND PP FT+A Y   V  D  VG+EL+ V A DAD G + LV +++        
Sbjct: 2590 VTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV-------- 2641

Query: 2894 LANDSEDVGQVFTMGSMDGILR 2915
                S D   +F +    G LR
Sbjct: 2642 ---SSGDPSGLFELDESSGTLR 2660



 Score =  796 bits (2057), Expect = 0.0
 Identities = 738/2515 (29%), Positives = 1148/2515 (45%), Gaps = 207/2515 (8%)

Query: 36   FDTYLLISEDTPV----GSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVW 88
            FD  L   E  P     GS V ++ A+D D   N  + + ++    + +F+++P +G++ 
Sbjct: 472  FDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIIT 531

Query: 89   LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
                LD E + +  +    +D        +  V++ + DVNDN P F    Y+  +PE T
Sbjct: 532  TAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGT 591

Query: 146  PVGTPIFIVNATDPDLGAGGSVLYSF--------QPPSQFFAIDSARGIVTVIRELDYET 197
              GT    V ATD D G  G + YS          PP   F ID+  G V   R LD + 
Sbjct: 592  QPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQ 648

Query: 198  -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
               ++  TV A D      L ++  + + ++D  D  P F    Y+ +I   SPPGT V 
Sbjct: 649  GPSSFDFTVTAVDGGG---LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705

Query: 257  IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKG 316
             + A D D+G    + Y I++GN+  +F LD  SG+LT+   L R     ++  +    G
Sbjct: 706  RLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARR----ANSVVQLEIG 761

Query: 317  TELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDK 376
             E   D     A  +   +I ++      P F   +Y  ++ E    G +    + +V  
Sbjct: 762  AE---DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTS----VGIVQA 814

Query: 377  DENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
                G  +   + L G +    + S  +V G     ++   PLD E +    + ++ A  
Sbjct: 815  HNPPGRLAPVTLSLSGGDPRG-LFSLDAVSG----LLQTLRPLDRELLGPVLELEVRAGS 869

Query: 436  SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
             VP     A+V++ L + NDN P F  P   + L  N   GT + T+ A D D+G    V
Sbjct: 870  GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRV 929

Query: 496  SY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVL 552
            ++   +     F++D  TG + L+  L         L + ARDGG    T   R+R+ V 
Sbjct: 930  TFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQ 989

Query: 553  DVNDN--VPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
            DV      P F    Y   L     + TQ+++++A   D  P   ITY + +  A  S F
Sbjct: 990  DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGA-SSPF 1045

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL---NSTVPVTIEVFDENDN 667
             +    G+  + V   LD E  +  L  L VMA+      L     T  V + + ++N++
Sbjct: 1046 GLEPQSGW--LWVRAALDRE--AQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101

Query: 668  PPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL----EGSTQFRINA 723
             P  S+   F++V EN   G +V  + ATD D S   G+  + YSL    E S  FRI+ 
Sbjct: 1102 SPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGR--LTYSLQQLSEDSKAFRIHP 1158

Query: 724  RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP- 782
            ++GE+TT   LDRE +S Y L+V+  DGG      TG  TV++ +LD+NDN PT+  A  
Sbjct: 1159 QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG--TVHVAVLDLNDNSPTFLQASG 1216

Query: 783  -----YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-PPNKFYSLNSTTGKIRTT 836
                   I + +  PP + VTT+ A DPD GENGT++Y++  P ++ +SL+  +G++ T 
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTA 1276

Query: 837  HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLL----------DLNDN 886
              ++  E P          + +S  D G PP  A  S  + V +L          DL + 
Sbjct: 1277 APLIRAERPH-------YVLTLSAHDQGSPPRSA--SLQLLVQVLPSARLAEPPPDLAER 1327

Query: 887  DPTFQNLPFVAEV--LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS 944
            DP    +P V  V   EG+  G S+   VA     G+  L    +    P   F ++++S
Sbjct: 1328 DPA-APVPVVLTVTAAEGLRPG-SLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAAS 1385

Query: 945  GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
            G +     LD E    ++   V ++      +    + + V D N+  P F      +++
Sbjct: 1386 GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALAL 1445

Query: 1005 SEDVPREFRVVWLNCTDND-VGLNAELSYFITGGNVD-GKFSVGYRDAVVRTVVGLDRET 1062
             E+      +     +D D  G N+++ Y +           +  R   +    GLDRET
Sbjct: 1446 PENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET 1505

Query: 1063 TAAYMLILEAIDN-GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
            T A +L++EA D      +R     +  V V D NDN P+F   S    +PED P G + 
Sbjct: 1506 TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAA 1564

Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
            L + A D D GE  RV YR+  G  G +FR+H S G L    RPLDRE+ + HVL V A 
Sbjct: 1565 LHVVARDPDLGEAARVSYRLASGGDG-HFRLHSSTGAL-SVVRPLDREQRAEHVLTVVAS 1622

Query: 1182 NHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
            +H   P  ++  + V V D+NDEAP F QQ+YS L LRE    GTS++ ++ATD D G  
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL-LRENNPPGTSLLTLRATDPDVGAN 1681

Query: 1242 GLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
            G V Y  +S     F +D  TG++ T+  LD E +    + V A D+  P      +V +
Sbjct: 1682 GQVTYGGVSSE--SFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV 1739

Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGT-EIVRVQAYSIDNLNQITYRFNAYTSTQAKA 1360
             + +E D A  F +A     + E     T  ++R     +    Q+ YR           
Sbjct: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRI---LDGDPSG 1796

Query: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFD 1419
             F +D  +G       +DRE    + L + A DGG P + +T+ + +TVLD ND++P F 
Sbjct: 1797 AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856

Query: 1420 FTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEV 1479
              + S V +PED P G  +  ++A DPDAG+NG V + L +G  AGAF +     S GE+
Sbjct: 1857 VPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLL---EPSSGEL 1911

Query: 1480 FVARPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVI-ESPFGYNV-S 1536
              A  LDRE+   Y   V A D     P      + +T+ D+ND+ P    SP    +  
Sbjct: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971

Query: 1537 VNENVGGGT-AVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP---P 1592
               +    T A+  +RA DRD G N+ + Y +  G       +D  +GEI    +P    
Sbjct: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARSPVALG 2030

Query: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
             R+R  F  +VAT  D G P  SAT  + V +  E +  P F +   E  + E      T
Sbjct: 2031 PRDRVLF--IVAT--DLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GT 2085

Query: 1653 SLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT--AAKELDYEISHGRYTLI 1710
             +++ +A+    G NG +TY+I++GN   TF I    G IT  +A+ LD+E+S  R  L+
Sbjct: 2086 PIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVS-PRLRLV 2143

Query: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP--GPRVWTFLA 1768
            + A       S    + T + + + D NDN P F R +   F + E +P  GP +    A
Sbjct: 2144 LQAE------SGGAFAFTVLTLTLQDANDNAPRFLRPHYVAF-LPESRPLEGP-LLQVEA 2195

Query: 1769 HDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
             D D G  GQ+ YS+    P  G F + P  G   +     LDRE  A   L + A DRG
Sbjct: 2196 DDLDQGSGGQISYSLAASQPARGLFHVDPTTGT--ITTTAILDREIWAETRLVLMATDRG 2253

Query: 1828 MPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
             P L  +  + + V+D NDN P +   P  + +SE++ + S +A V  +D DSG    L 
Sbjct: 2254 SPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG--PVLW 2310

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLI 1947
            + ++    +  F +    G V++  PLD E+   Y+L +   D P   R        L +
Sbjct: 2311 YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN------LTV 2364

Query: 1948 FLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS 2007
             + D NDN P F++S YQ  ++E++P G+ +      + A D D      ++Y L     
Sbjct: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL----SVSATDRDSGANGHISYHLASPAD 2420

Query: 2008 GLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDND 2064
            G F ++ + G + T+   V +  +      ++++L A D G     A   + + + D ND
Sbjct: 2421 G-FSVDPNNGTLFTIVGTVALGHDGSG--AVDVVLEARDHGAPGRAARATVHVQLQDQND 2477

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAGAQDRFLIHLVTG 2123
            + P+F+ +   V + E+ PPG ++L + ATD D   +   V Y I +G   R +  L   
Sbjct: 2478 HAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPR 2536

Query: 2124 VIRVGNAT---------------IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
            +   G +                +D E    Y LTV A DRG  P S    VT+ + D+N
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596

Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQE 2228
            D+ P F      V+V E    G  + ++ A D D  P         V+  D   L     
Sbjct: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT--VSSGDPSGL----- 2649

Query: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
              F ++ ++G++ +   ++ E  A +++ +   D A            A +T+ V DVND
Sbjct: 2650 --FELDESSGTLRLAHALDCETQARHQLVVQAADPA------GAHFALAPVTIEVQDVND 2701

Query: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE- 2347
            + P F    +      + E   PGT +  + A+D D G  G + Y+LL+   PG    E 
Sbjct: 2702 HGPAFP---LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGREA 2757

Query: 2348 ---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
               +SS G++ A    DYE        V A+D G+   +A + V + +   ++ +P+F  
Sbjct: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLA 2815

Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459
            P++   V E    G  +  V ATD D G   L+ YSL      F IN TTG +Y+
Sbjct: 2816 PAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870



 Score =  789 bits (2037), Expect = 0.0
 Identities = 801/2917 (27%), Positives = 1266/2917 (43%), Gaps = 257/2917 (8%)

Query: 139  VRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQF---FAIDSARGIVTVIREL 193
            ++I E  P GT I  ++A  P  G    ++Y  S Q  S      AID   G+V   R L
Sbjct: 49   LQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107

Query: 194  DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
            D E    Y+ T    D            + + + D+ D  P F     +  + EH+  GT
Sbjct: 108  DREQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160

Query: 254  TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV-------LTLNGLLDRENPLY 306
               +  A D D GR    GY +        F L+   G        L + G LDREN   
Sbjct: 161  RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR-- 218

Query: 307  SHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFA 366
            SH ++L ++  +       + A +  T    ++DIND+AP FN S Y   ++E    G  
Sbjct: 219  SH-YMLQLEAYDGGSPPRRAQALLDVT----LLDINDHAPAFNQSRYHAVVSESLAPGSP 273

Query: 367  LPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
            +   +QV   D + G+N      +    S      P S+     + +++  PLD+E    
Sbjct: 274  V---LQVFASDADAGVNGAVTYEINRRQSEGD--GPFSIDAHTGL-LQLERPLDFEQRRV 327

Query: 427  YDFDLFANES-VPDHVGYAKVKITLINENDNRP----IFSQPLYNISLYENVTVGTSVLT 481
            ++  + A +      +G A V + + + NDN+P    IF     +  + E    G  V  
Sbjct: 328  HELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVAR 387

Query: 482  VLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIA---RLDYELIQRFTLTIIARDG 538
            +  +D D G F  V+         F+L     +I L+    RLD E    + L + A D 
Sbjct: 388  ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDS 447

Query: 539  GGEETTGRVR--INVLDVNDNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQ 595
            G           ++V DVNDN P F +  Y    L E     + +VR+ A D D   N Q
Sbjct: 448  GSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507

Query: 596  ITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTV 655
            +TYS+ +  A   +F I    G  +I+ +  LDYE        L V+A D G PPL S+ 
Sbjct: 508  VTYSL-APGAHTHWFSIDPTSG--IITTAASLDYELEPQP--QLIVVATDGGLPPLASSA 562

Query: 656  PVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-- 713
             V++ + D NDN P F +  Y  S+ E    G   L + ATD D S  +G  S  YSL  
Sbjct: 563  TVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDAD-SGPFGLLS--YSLGA 619

Query: 714  ----EGSTQFRINARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITL 768
                 GS  FRI+A SG++ TT  LDR+   S +   V AVDGG        +  V + L
Sbjct: 620  GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG----GLKSMVYVKVFL 675

Query: 769  LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSL 826
             D NDN P +    Y  ++   +PP + V  + A DPD G +G L Y I   N    ++L
Sbjct: 676  SDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTL 735

Query: 827  NSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDN 886
            +  +G +     +  R N        + ++ +   D G   L+A  SA V ++++     
Sbjct: 736  DEQSGLLTVAWPLARRANS-------VVQLEIGAEDGGG--LQAEPSARVDISIVPGTPT 786

Query: 887  DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV 946
             P F+ L +V  V E +  G S+  +V      G    V+  +  G PR  F +++ SG+
Sbjct: 787  PPIFEQLQYVFSVPEDVAPGTSV-GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845

Query: 947  VVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSE 1006
            + T   LDRE +       V + +G P   + + + + + DVND +P F      V +  
Sbjct: 846  LQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPP 905

Query: 1007 DVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAY 1066
            +      +  L   D D G+N+ +++ +  G   G F+V      VR +  L      A+
Sbjct: 906  NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAH 964

Query: 1067 MLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
             L LEA D G   +       V V  +      P F   +Y   +P     G  +LQ++A
Sbjct: 965  ELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQA 1024

Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH--- 1183
               D G    + Y +      + F +   +G L      LDRE    ++L V A +    
Sbjct: 1025 QAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAA-LDREAQELYILKVMAVSGSKA 1080

Query: 1184 DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
            +LG    +  V V + + N+ +P  ++   + L + E    GTSV  V ATDRDSG  G 
Sbjct: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDP-TFLAVAENQPPGTSVGRVFATDRDSGPNGR 1139

Query: 1244 VNYRI--LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
            + Y +  LS     F I   TG + T+  LD E ++SY + V   D   P      +V++
Sbjct: 1140 LTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV 1199

Query: 1302 TLLNELDEAVQFSNASYEAA------ILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355
             +L+  D +  F  AS  A       + + +  GT +  +QA   D     T     YT 
Sbjct: 1200 AVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI---LYTL 1256

Query: 1356 T-QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVL---- 1409
            T     LF +   +G +     + R +   Y LT+ A D G P   +++++ + VL    
Sbjct: 1257 TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSAR 1316

Query: 1410 ------DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG-N 1462
                  D  +  P         V+  E    G  + +V A  P+    G + ++L  G +
Sbjct: 1317 LAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYTLVGGAD 1374

Query: 1463 IAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
              G F +   +   G +++ARPLD E    +    V ++       +   +QV + D N+
Sbjct: 1375 PEGTFALDAAS---GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENE 1431

Query: 1523 NPPVI-ESPFGYNVSVNENVGGGTAVVQVRATDRD-IGINSVLSYYITEGNKDM-AFRMD 1579
            + P     P    +++ EN   G A+   RA+D D  G NS + Y +      + A R+D
Sbjct: 1432 HAPAFARDPLA--LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLD 1489

Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPT-----LSATTHVYVTIVDENDNAPMF 1634
              +G ++   AP   +R++   L+  VE    P       +A     V + DENDNAP+F
Sbjct: 1490 ARTGALS---APRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF 1546

Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
              P    L ++ P     + + + A D D G    V+Y + +G   + FR+    G ++ 
Sbjct: 1547 ASPSRVRLPEDQPP--GPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSSTGALSV 1603

Query: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV 1754
             + LD E     + L V A+D     S   ++T  + V+V D+ND  PTF +        
Sbjct: 1604 VRPLDRE-QRAEHVLTVVASDHG---SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659

Query: 1755 TEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI 1814
                PG  + T  A D D G NGQV Y  +  +    F + P  GVL   +   LDRE  
Sbjct: 1660 ENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFSLDPDTGVLTTLR--ALDREEQ 1714

Query: 1815 AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVL 1874
               NLT+ A+DRG PP  + + V + V D ND+ P   +  +++ + E     +    + 
Sbjct: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LR 1773

Query: 1875 ASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
            ASD D G N +L + I  G+   AF ++  +G     RPLDRE  P ++L I  +D  + 
Sbjct: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833

Query: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDI 1994
               A     LL + + D ND+ P F    Y  EV E+ PAGT L  L     A D D   
Sbjct: 1834 ALSATL---LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ----AHDPDAGA 1886

Query: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED---IGLLNS 2051
               VTY L    +G F +  S+G   +R+   +DRE    P     + A D    G L++
Sbjct: 1887 NGHVTYYLGAGTAGAFLLEPSSG--ELRTAAALDREQC--PSYTFSVSAVDGAAAGPLST 1942

Query: 2052 TAHLLITILDDNDNRPTFSPATLTVHLLENCP----PGFSVLQVTATDEDSGLNGELVYR 2107
            T  + IT+ D ND+ PTF  + L + L    P    P  ++  + A D D+G N  ++YR
Sbjct: 1943 TVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR 2002

Query: 2108 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
            +         +   TG IRV  + +    ++   L +VATD G    S T ++ + +   
Sbjct: 2003 LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV-LFIVATDLGRPARSATGVIIVGLQGE 2061

Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-LNPKLEYHIVGIVAKDDTDRLVPN 2226
             +  P F       ++ E+A PGT I +  A+     N  + Y I           L  N
Sbjct: 2062 AERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSI-----------LSGN 2110

Query: 2227 QEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
            ++  F++  +TG++ V+S    +   +  + L +        E   +     LT+ + D 
Sbjct: 2111 EKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL------QAESGGAFAFTVLTLTLQDA 2164

Query: 2287 NDNTPQF-KPFGITYYME-RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
            NDN P+F +P  + +  E R LEG      L+ V A D D+G  G ++Y+L    P   +
Sbjct: 2165 NDNAPRFLRPHYVAFLPESRPLEGP-----LLQVEADDLDQGSGGQISYSLAASQPARGL 2219

Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
               D + G +     +D E        + A+D GSP       + + ++D NDN P   Q
Sbjct: 2220 FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ 2279

Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
            P ++  V ED  +G+ I  VT  D DSG       S    +  F++    G + +   LD
Sbjct: 2280 P-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLD 2338

Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
             E+ D Y L  LA D P        E    + + V DVND  P FS+  +   + E+ P 
Sbjct: 2339 FEQCDRYQLQLLAHDGP-------HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391

Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLV-----TTQRPLQSYEKFSL 2579
            G++++++ ATD+D G NG ++Y L  P  + F VD ++G +     T            +
Sbjct: 2392 GSAILSVSATDRDSGANGHISYHLASPA-DGFSVDPNNGTLFTIVGTVALGHDGSGAVDV 2450

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIR----EEIPLRSNVYEV 2635
             + A D G P       + V++ D ND+ P F      T+ H R    E++P  S +  +
Sbjct: 2451 VLEARDHGAPGRAARATVHVQLQDQNDHAPSF------TLSHYRVAVTEDLPPGSTLLTL 2504

Query: 2636 YATDKDEGLN-GAVRYSFLKTAGNRDW-EFFIIDP--------------ISGLIQTAQRL 2679
             ATD D   +  AV YS +  +GN  W   F ++P                G +   + L
Sbjct: 2505 EATDADGSRSHAAVDYSII--SGN--WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560

Query: 2680 DRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPE 2739
            D ES   Y+L + A+D GQP P  ++ P+ V + D++DN P+F R       Y++ TVPE
Sbjct: 2561 DFESLTQYNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVFTRA-----SYRV-TVPE 2613

Query: 2740 HSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDREREAI 2798
             +P G  + +V  A DAD GP+ +V + +++G+    F L +  G L +   LD E +A 
Sbjct: 2614 DTPVGAELLHVE-ASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672

Query: 2799 FSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATD 2858
               +V+A+       P G        A   L  V + ++D+ND  P F     +  VA +
Sbjct: 2673 HQLVVQAAD------PAG--------AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAEN 2718

Query: 2859 AKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFD 2918
               G+ +  + A+D D G    + YS+L        A    +  + F + S  G LR   
Sbjct: 2719 QPPGTLVTTLHAIDGDAGAFGRLRYSLLE-------AGPGPEGREAFALNSSTGELRARV 2771

Query: 2919 LFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQ 2955
             F       F + + A D    + +  + + +  +D+
Sbjct: 2772 PFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDE 2808



 Score =  664 bits (1712), Expect = 0.0
 Identities = 636/2215 (28%), Positives = 983/2215 (44%), Gaps = 183/2215 (8%)

Query: 42   ISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
            + ED   G+SV  + A +      P+   +SG +    F+++  +G++   +PLDRE   
Sbjct: 799  VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858

Query: 100  EFTVEFSVSDHQGV----ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
               +E  V    GV       +V + + DVNDN+P F     +V +P NT  GTPI+ + 
Sbjct: 859  P-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917

Query: 156  ATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
            A DPD G    V ++        F +D   G V ++R L      A++L + A D     
Sbjct: 918  ALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP- 976

Query: 215  PLSTLANLAIIITDV--QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
            P ++   L +++ DV  + + P F +  Y  ++   +  GT V  + A   D G    I 
Sbjct: 977  PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---IT 1033

Query: 273  YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
            Y + +   +S F L+  SG L +   LDRE        ++ V G++          T T 
Sbjct: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAE----LGQQTGTA 1089

Query: 333  TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
            T  + +++ N+++P  +     +A+ E    G ++   +   D+D        + +  + 
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR-VFATDRDSGPNGRLTYSLQQLS 1148

Query: 393  NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLI 451
             +S  F I P + +      +     LD E    Y   +   +   P       V + ++
Sbjct: 1149 EDSKAFRIHPQTGE------VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202

Query: 452  NENDNRPIFSQPL------YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PD 504
            + NDN P F Q          I + + V  GT V T+ A D D G  G + Y  +    +
Sbjct: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262

Query: 505  RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKD 564
             FSL   +G ++  A L       + LT+ A D G    +  +++ V      +P+ +  
Sbjct: 1263 LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLV----QVLPSARLA 1318

Query: 565  AYVGALRENEPSVTQLVRLRATDED-----------SPPN----NQITYSIVSASAFGSY 609
                 L E +P+    V L  T  +           + P       +TY++V  +     
Sbjct: 1319 EPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT 1378

Query: 610  FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
            F  +L    G + ++RPLD+E        LTV A   G       + V ++V DEN++ P
Sbjct: 1379 F--ALDAASGRLYLARPLDFEA-GPPWRALTVRAEGPGGAGAR-LLRVQVQVQDENEHAP 1434

Query: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLD--------RSREYGQESIIYSLEGSTQFRI 721
             F++    +++ EN   GA +    A+D D        R R   QE  + +L      R+
Sbjct: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPAL------RL 1488

Query: 722  NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI-ATVNITLLDINDNHPTWKD 780
            +AR+G ++    LDRET    +L+V A D     +++     +  + + D NDN P +  
Sbjct: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA- 1547

Query: 781  APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAM 839
            +P  + L E  PP      VVA DPDLGE   + Y +       + L+S+TG +      
Sbjct: 1548 SPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRP- 1606

Query: 840  LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
            LDRE    H       + V  +D G PP  AT   TV V   D+ND  PTFQ   +   +
Sbjct: 1607 LDREQRAEHV------LTVVASDHGSPPRSATQVLTVSV--ADVNDEAPTFQQQEYSVLL 1658

Query: 900  LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
             E  P G S+  + A D D G NG V+Y    G+    F ++  +GV+ T   LDRE   
Sbjct: 1659 RENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQE 1715

Query: 960  EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
            E  L V A D G+P + +  T+ + V D ND  PTF  A  ++ V E    +  +  L  
Sbjct: 1716 EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRA 1774

Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
            +D DVG N +L Y I  G+  G F +        T+  LDRE   A+ L +EA D G   
Sbjct: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834

Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY 1139
               + T  + VTVLD ND+ P F   +Y   VPED+P G  +LQL+A D D G  G V Y
Sbjct: 1835 L--SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892

Query: 1140 RILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-GPMRSSVRVIVYV 1198
             +  G  G  F +  S+G L R    LDRE+  S+   V A +    GP+ ++V V + V
Sbjct: 1893 YLGAGTAGA-FLLEPSSGEL-RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950

Query: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVV---QATDRDSGDGGLVNYRILSGAEGK 1255
             D+ND AP F          R      T  + +   +A DRD+G    + YR+       
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010

Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
              +D  TG I              ++ + ATD   P       + + L  E +   +F  
Sbjct: 2011 TTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070

Query: 1316 ASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
            AS EA I EN   GT IV  +A      N  ITY   +  S   K  F I   TG ITV+
Sbjct: 2071 ASSEATIRENAPPGTPIVSPRAVHAGGTNGPITY---SILSGNEKGTFSIQPSTGAITVR 2127

Query: 1375 GL--VDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDC 1432
                +D E      L + A+ GG    + +   +T+ D NDN+PRF         +PE  
Sbjct: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFTVLT--LTLQDANDNAPRF-LRPHYVAFLPESR 2184

Query: 1433 PVGQRVATVKAWDPDAGSNGQVVFSLASGNIA-GAFEIVTTNDSIGEVFVARPLDREELD 1491
            P+   +  V+A D D GS GQ+ +SLA+   A G F +  T  +I    +   LDRE   
Sbjct: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAI---LDREIWA 2241

Query: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
               L ++A+DRG+P       L V ++D NDN P I  P  + + V+E+   G+ + QV 
Sbjct: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP--WELRVSEDALLGSEIAQVT 2299

Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED--- 1608
              D D G   VL Y ++       F + R  G ++    P D E+   Y L     D   
Sbjct: 2300 GNDVDSG--PVLWYVLSPSGPQDPFSVGRYGGRVSLT-GPLDFEQCDRYQLQLLAHDGPH 2356

Query: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668
            EG   L+      V + D NDNAP F Q  Y+V+L E      ++++++ A D D G NG
Sbjct: 2357 EGRANLT------VLVEDVNDNAPAFSQSLYQVMLLEHTPP-GSAILSVSATDRDSGANG 2409

Query: 1669 TVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLT 1725
             ++Y + +    + F +D + G    I     L ++ S G   +++ A D     +    
Sbjct: 2410 HISYHLASP--ADGFSVDPNNGTLFTIVGTVALGHDGS-GAVDVVLEARDHG---APGRA 2463

Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRD-SGPNGQVEYSIM 1784
            +  TV V + D ND+ P+F   +       +  PG  + T  A D D S  +  V+YSI+
Sbjct: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523

Query: 1785 DGDPLGEFVISP--------------VEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             G+    F + P                G L + +   LD E++  YNLT+ A DRG PP
Sbjct: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP--LDFESLTQYNLTVAAADRGQPP 2581

Query: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
             SS + V + VLD+NDN PV       +T+ E++PV + + HV ASDAD G +  + F +
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641

Query: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
            ++G+    F ++ ++G + +   LD E    ++L +   D    P  A      + I + 
Sbjct: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQ 2697

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
            D ND+ P F  +     V EN P GT +T L+    A+D D   +  + Y LL A  G  
Sbjct: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH----AIDGDAGAFGRLRYSLLEAGPGPE 2753

Query: 2009 ---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
                F +NSSTG   +R+ V  D E        LL+ A D G L+++  + + +  +++ 
Sbjct: 2754 GREAFALNSSTG--ELRARVPFDYE--HTESFRLLVGAADAGNLSASVTVSVLVTGEDEY 2809

Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVI 2125
             P F        + E    G S+  V ATDED G +G ++Y + A +   F I+  TG +
Sbjct: 2810 DPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGAL 2868

Query: 2126 RV---------------GNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILID 2165
             +               G     RE     RL V+A  RG +P S +A V + +D
Sbjct: 2869 YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA--RGPLPGSRSATVPVTVD 2921


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  899 bits (2324), Expect = 0.0
 Identities = 832/2924 (28%), Positives = 1356/2924 (46%), Gaps = 246/2924 (8%)

Query: 38   TYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
            T + + E+ PVGSSV  + + D+D   N  LV+ VSG      F ++ +TG++ +  PLD
Sbjct: 722  TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLD 781

Query: 95   RETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
            RET  ++T+  +V D    Q    R +++ V D NDN P F  + Y V + E+  V + I
Sbjct: 782  RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841

Query: 152  FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
              V ATD DLG  G V YS    +  F+IDS  G+V + R LD E    + L + A DQ 
Sbjct: 842  IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA 901

Query: 212  KTRP-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
            +  P L +   + + + DV D  P FI   Y   + E  P GT +  + A D D G+   
Sbjct: 902  REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQ 961

Query: 271  IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
            + Y+++     + F +D +SG + +   LD E       + LTV+     D   P   + 
Sbjct: 962  VRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEK---KQVYNLTVRA---KDKGKPVSLSS 1014

Query: 331  TTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
            T    + V+D+N+N   P F+S      + E A VG +L + +   D+D        + +
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG-SLVMTVSAHDEDARRDGEIRYSI 1073

Query: 389  YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVK 447
               G+    F I      G+    I  +  LD E+   Y   +FA ++ V     + ++ 
Sbjct: 1074 -RDGSGVGVFKI------GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126

Query: 448  ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR- 505
            I + + NDN P  S+P+Y   + EN     SV+ + A D D+ +  ++ Y   S +P   
Sbjct: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGF 1186

Query: 506  FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQ 562
            FS+   TGLI   +R LD E      L +   D G   + T  RV + +LD NDN P F 
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL 1246

Query: 563  KDAYVGALRENEPSVTQ-------LVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
            +  Y   L E E    +       L  + ATD+D  PN +I+YSI   +  G +F   + 
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF---IE 1303

Query: 616  EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE---NDNPPTFS 672
               GV+S  R       +     L++ A+D G P  +ST  + IE   +   +  P +F 
Sbjct: 1304 PKTGVVSSKR----FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFE 1359

Query: 673  KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEIT 729
            +  +  +V+E+      +  +       S E     + + + G    + F ++  +G I 
Sbjct: 1360 ESFFTFTVMESDPVAHMIGVI-------SVEPPGIPLWFDITGGNYDSHFDVDKGTGTII 1412

Query: 730  TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 789
                LD E KS Y L V A DG       T +  V I ++D ND+ P +  + Y + + E
Sbjct: 1413 VAKPLDAEQKSNYNLTVEATDG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPE 1467

Query: 790  MTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-----KFYSLNSTTGKIRTTHAMLDREN 844
             T P++++  + AVD D  E   L+Y++Q        K + L+  TG + T+  +     
Sbjct: 1468 DTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKL----- 1520

Query: 845  PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIP 904
               HEA     + V V D   P  +  + A + VN+ D ND+ P F    +   V E   
Sbjct: 1521 --DHEAVHQHTLTVMVRDQDVPVKR--NFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576

Query: 905  AGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR 964
             G  + QV A+D D+G N  V Y +  G     F+I+   G + T  ELDR   AEY L 
Sbjct: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636

Query: 965  VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
            V A+D G+P  S  +++ I V   ++ +P F    Y+V +SE V     V  +       
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS--- 1693

Query: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTG 1084
               + + Y I  GN    F +      + T   LD ET   Y LI++  +   +    + 
Sbjct: 1694 --QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL----ST 1747

Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPED-------IPEGHSILQLKATDADEGEFGRV 1137
              TV V + D NDN P+F+Q+ Y   + E        + + +  L ++A DAD+     +
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807

Query: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR----SSVR 1193
             Y I+  +    F I  S G +      LD E  S     V+   HD+G  R     +  
Sbjct: 1808 VYHIVEPSVHTYFAIDSSTGAI-HTVLSLDYEETSIFHFTVQV--HDMGTPRLFAEYAAN 1864

Query: 1194 VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE 1253
            V V+V DIND  PVF +  Y    L  T   G  VI V ATD DS     + Y I  G  
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYK-GVKVITVNATDADSSAFSQLIYSITEGNI 1923

Query: 1254 G-KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQ 1312
            G KF +D  TG +   N    + ++ Y + V A+D       G  SV I +    +  ++
Sbjct: 1924 GEKFSMDYKTGALTVQN--TTQLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978

Query: 1313 FSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVIT 1372
            F+   Y A + EN      +  + A   + +N+  +    Y        FKI   +GV++
Sbjct: 1979 FTQDVYSAVVKENSTEAETLAVITAIG-NPINEPLF----YHILNPDRRFKISRTSGVLS 2033

Query: 1373 VQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430
              G   DRE+ + + + V V ++  P   + V V + V D+NDN+P F      AV +  
Sbjct: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV-VKV 2092

Query: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
            D  VG  +  V A D D+G NG+V + L   +    F+I      +GE+ + +  + + L
Sbjct: 2093 DTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQI----GPLGEISLKKQFELDTL 2146

Query: 1491 D-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549
            +  Y++ VVA D G P    + I+ +T++  N   PV E PF Y+  + E++   + VV 
Sbjct: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF-YSAEIAESIQVHSPVVH 2203

Query: 1550 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE 1609
            V+A   + G+   + Y IT+G+    F ++  +G I    AP D E    Y L     D 
Sbjct: 2204 VQANSPE-GLK--VFYSITDGDPFSQFTINFNTGVINV-IAPLDFEAHPAYKLSIRATDS 2259

Query: 1610 GTPTLSATTHVYVTIV--DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
             T    A   V+V I+  D NDN P+F Q  Y V L E    + TS++ ++A D D  PN
Sbjct: 2260 LT---GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEA-SVIGTSVVQVRATDSDSEPN 2315

Query: 1668 GTVTYAIVAGNIV--NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD-QCPILSHRL 1724
              ++Y +   +    + F +D   G+I+  + LDYE S  ++T+ V A D   P LS   
Sbjct: 2316 RGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR-QHTIFVRAVDGGMPTLS--- 2371

Query: 1725 TSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYS 1782
             S   V V+V D+NDN P F +  YE    ++E  P G  V    A+D DS    +++YS
Sbjct: 2372 -SDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYDADSSDIDKLQYS 2428

Query: 1783 IMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTICARDRGMPPLSSTMLVGIRV 1841
            I+ G+    FVI    G++ +     L R  +  FY+L +   D       S+  V + V
Sbjct: 2429 ILSGNDHKHFVIDSATGIITLS---NLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTV 2482

Query: 1842 LDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFI 1901
            +  N + P  L     + ++EN+P+ + V  V  +D DSG    +T++I     +  F+I
Sbjct: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542

Query: 1902 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
            N    I T+ + LDRE   E  +++ +       ++A   +  + + L+D+NDN P F  
Sbjct: 2543 NERGQIFTLEK-LDRETPAEKVISVRLMAKDAGGKVA---FCTVNVILTDDNDNAPQFRA 2598

Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGL---FDINSSTGV 2018
            + Y+  +  ++  GT +      +LA DAD+   A +TY +      +    +IN  +GV
Sbjct: 2599 TKYEVNIGSSAAKGTSVV----KVLASDADEGSNADITYAIEADSESVKENLEINKLSGV 2654

Query: 2019 VTVRSGVI-IDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLT 2075
            +T +  +I ++ E F+       + A D G  +  + +L  + IL      P FS    T
Sbjct: 2655 ITTKESLIGLENEFFT-----FFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYT 2709

Query: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTGVIRVGN 2129
              + E+ P G  +  + A       +G ++Y +      E+   + F+I   +G +++  
Sbjct: 2710 FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKL-E 2763

Query: 2130 ATIDREEQESYRLTVVA-TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
             ++D E  + Y+ +++A   +    +  +  V+I + D ND+ P F +      ++E+  
Sbjct: 2764 KSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823

Query: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
             G+ +  I A D D   N ++ Y +       D  + V   E +FA+N+ TG +     +
Sbjct: 2824 GGSRVIQIRASDADSGTNGQVMYSL-------DQSQSVEVIE-SFAINMETGWITTLKEL 2875

Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
            + E    Y++ +   D+   +   S ++    + V V DVND+ P+F       Y   + 
Sbjct: 2876 DHEKRDNYQIKVVASDHGEKIQLSSTAI----VDVTVTDVNDSPPRFT---AEIYKGTVS 2928

Query: 2307 EGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEE 2364
            E    G  +  ++  D D + +N  VTY +    P G   +E   +  KV   + +D E+
Sbjct: 2929 EDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREK 2988

Query: 2365 VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTV 2424
                  T+ A+D     +A    V ++++D NDN+P+ ++  Y + + EDV  G +I+ +
Sbjct: 2989 RDNYLLTITATDGTFSSKAI---VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045

Query: 2425 TATDADSGNFALIEYS-LGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGD 2483
            +ATDAD  + A I Y+ LG G  KF +NP TG++   + LDRE++  Y L   A D  G 
Sbjct: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG- 3104

Query: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGE 2543
                 R     +V+ + DVND  P+FS   ++ +V+EN   GT +  + ATD D G N +
Sbjct: 3105 -----RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRK 3159

Query: 2544 LTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEP-PLWGTTMLLVE 2600
            + YSL       F ++  SG++  ++PL  +    ++L++ A D G P  L  T  ++V 
Sbjct: 3160 ILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVS 3219

Query: 2601 VIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2660
            V+D+NDN PVF     G    + E+I + + V +VYA  +D   N  + YS +  +GN  
Sbjct: 3220 VLDINDNPPVFEYREYGAT--VSEDILVGTEVLQVYAASRDIEANAEITYSII--SGNEH 3275

Query: 2661 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2720
             + F ID  +G +   + LD ES   Y L + A+D G P     +  + V + DI+DN P
Sbjct: 3276 GK-FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP-SLSDVATVNVNVTDINDNTP 3333

Query: 2721 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ 2780
            +F      S       + E +     V  V  A DAD   N+ ++Y I  GN+  +F + 
Sbjct: 3334 VF------SQDTYTTVISEDAVLEQSVITVM-ADDADGPSNSHIHYSIIDGNQGSSFTID 3386

Query: 2781 P-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
            P  G + V + LDRE  + ++  V+AS N S  PPR  + T           V + + D+
Sbjct: 3387 PVRGEVKVTKLLDRETISGYTLTVQASDNGS--PPRVNTTT-----------VNIDVSDV 3433

Query: 2840 NDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFY 2883
            ND  P F++  Y+  +  +  VG  ++Q++  D D  +N   F+
Sbjct: 3434 NDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFF 3477



 Score =  871 bits (2250), Expect = 0.0
 Identities = 826/2962 (27%), Positives = 1343/2962 (45%), Gaps = 281/2962 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLV-FGVSGEEASRFFAVEPDTGVVWLRQPL--DRETK 98
            I  D  VG  +T + A D D   LV + +       FF++ P++GV+ L++ L      K
Sbjct: 578  IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637

Query: 99   SEF-TVEFSVSDHQGVIT------------RKVNIQVGD--------------------- 124
              F ++  + +D +   T            + VN+Q  +                     
Sbjct: 638  VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697

Query: 125  -----------VNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ 172
                       VN + P F +  P  +++ EN PVG+ +  +N+TD D G  G ++Y+  
Sbjct: 698  EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757

Query: 173  PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLA-IIITDV 229
              ++   F ID   G++ ++  LD ETT  Y  T+N T  D   P      L  +++ D 
Sbjct: 758  GGNEDSCFMIDMETGMLKILSPLDRETTDKY--TLNITVYDLGIPQKAAWRLLHVVVVDA 815

Query: 230  QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI 289
             D  P F+   Y   + E     + +  + A D+D G    + Y+IV+      F++D +
Sbjct: 816  NDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSV 873

Query: 290  SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN 349
            +GV+ +   LDRE     H   L ++  +   +     +TV     + + D+NDN P F 
Sbjct: 874  TGVVNIARPLDRE---LQHEHSLKIEARDQAREEPQLFSTVVV--KVSLEDVNDNPPTFI 928

Query: 350  SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA 409
               Y V + E    G  + ++++  D D  LG +      L+ +   +F +       K 
Sbjct: 929  PPNYRVKVREDLPEGTVI-MWLEAHDPD--LGQSGQVRYSLLDHGEGNFDVD------KL 979

Query: 410  DIRIRVAIPLDYETVDRYDFDLFANESVP----DHVGYAKVKITLINENDNRPIFSQPLY 465
               +R+   LD+E    Y+  + A +           Y +V++  +NEN + P+FS  + 
Sbjct: 980  SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039

Query: 466  NISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDY 523
              ++ E+  VG+ V+TV A D DA   GE+ Y   D      F + ++TG+I    RLD 
Sbjct: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDR 1099

Query: 524  ELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
            E    + LT+ A D G    +    + I V DVNDN P   +  Y   + EN P    +V
Sbjct: 1100 ESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV 1159

Query: 582  RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLT 640
            ++ A D DS  N+++ Y I S +  G +   S++   G+I+  SR LD EQ    ++ +T
Sbjct: 1160 QIEAFDPDSSSNDKLMYKITSGNPQGFF---SIHPKTGLITTTSRKLDREQQDEHILEVT 1216

Query: 641  VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT-------VLFL 693
            V   D G+PP ++   V +++ DENDN P F +  Y + + E              +  +
Sbjct: 1217 VT--DNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV 1274

Query: 694  NATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEY-ILIVRAV 749
             ATD D   E     I YS+E   +   F I  ++G +++          EY IL ++AV
Sbjct: 1275 IATDKD---EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF---SAAGEYDILSIKAV 1328

Query: 750  DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT-TVVAVDPDLG 808
            D G    QK+    ++I  +         K  P   +L  ++  +S  T TV+  DP   
Sbjct: 1329 DNG--RPQKSSTTRLHIEWIS--------KPKP---SLEPISFEESFFTFTVMESDPVAH 1375

Query: 809  ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDR-------ENPDPHEAELMRKIVVSVT 861
              G  V S++PP      + T G    +H  +D+         P   E +    + V  T
Sbjct: 1376 MIG--VISVEPPGIPLWFDITGGNY-DSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEAT 1432

Query: 862  DCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEG- 920
            D        T    VF+ ++D ND+ P F    +   + E       I Q+ A+D DE  
Sbjct: 1433 DG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487

Query: 921  --LNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
              +  L S R P+ + +  F ++ ++G + T+ +LD E + ++ L V+  D   P K + 
Sbjct: 1488 KLIYTLQSSRDPLSLKK--FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNF 1545

Query: 979  STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
            + + ++V D ND  P F  + Y   V E       V+ +   D D G NAE+ Y I  GN
Sbjct: 1546 ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGN 1605

Query: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
            +   F +      ++T   LDR   A Y L+++A D G        +  +FVT+ D  + 
Sbjct: 1606 IGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD--NA 1663

Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL 1158
             P F    Y   + E +  G  +  + A          V Y I  GN G+ F I+  +G 
Sbjct: 1664 SPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGT 1718

Query: 1159 LMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGL 1218
            ++   + LD E    + LI++  N  +  + ++  V+V+++D ND APVF Q +Y+ L +
Sbjct: 1719 IIT-QKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQAEYTGL-I 1774

Query: 1219 RETAGIGTSVI-------VVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNY 1270
             E+A I + V+       V++A D D     L+ Y I+       F ID STG I TV  
Sbjct: 1775 SESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS 1834

Query: 1271 LDYETKTSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLAL 1328
            LDYE  + +   V   D   P  F +   +V + +++  D    F+   YEA++L     
Sbjct: 1835 LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYK 1894

Query: 1329 GTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
            G +++ V A   D+   +Q+ Y   + T       F +D  TG +TVQ          Y 
Sbjct: 1895 GVKVITVNATDADSSAFSQLIY---SITEGNIGEKFSMDYKTGALTVQNTTQLRSR--YE 1949

Query: 1387 LTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDP 1446
            LTV A DG  +      V I V +  ++  +F     SAV + E+    + +A + A   
Sbjct: 1950 LTVRASDG--RFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAETLAVITAIGN 2006

Query: 1447 DAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPP 1506
                N  + + +   N    F+I  T+  +       P DRE+ + + + V  ++   P 
Sbjct: 2007 PI--NEPLFYHIL--NPDRRFKISRTSGVLSTT--GTPFDREQQEAFDVVVEVTEEHKPS 2060

Query: 1507 RKKDHILQVTILDINDNPPV-IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSY 1565
                 +++V + D NDN PV +  P+   V V+  VG    +  V A DRD G N  + Y
Sbjct: 2061 AVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH--VIRYVTAVDRDSGRNGEVHY 2118

Query: 1566 YITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIV 1625
            Y+ E ++   F++  + GEI+ +           Y +    +D G P  SA   V +T++
Sbjct: 2119 YLKEHHEH--FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM 2175

Query: 1626 DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFR 1684
              N   P+F++P Y   + E    +++ ++ +QA      P G  V Y+I  G+  + F 
Sbjct: 2176 --NKAMPVFEKPFYSAEIAESIQ-VHSPVVHVQA----NSPEGLKVFYSITDGDPFSQFT 2228

Query: 1685 IDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
            I+ + GVI     LD+E +H  Y L + ATD          +   V + V+DINDN P F
Sbjct: 2229 INFNTGVINVIAPLDFE-AHPAYKLSIRATDSLT----GAHAEVFVDIIVDDINDNPPVF 2283

Query: 1745 PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE--FVISPVEGVLR 1802
             +             G  V    A D DS PN  + Y +          F +    G++ 
Sbjct: 2284 AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLIS 2343

Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
            + +   LD E    + + + A D GMP LSS ++V + V D+NDN P+         ISE
Sbjct: 2344 LLRT--LDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401

Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
            ++P   FV  V A DADS    +L ++I +GN  + F I++ TGI+T++        P Y
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFY 2461

Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
             L +SV D         R    + + +   N + P F ++ Y+ E+ EN+P  T    L 
Sbjct: 2462 SLNLSVSDG------VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHT----LV 2511

Query: 1983 GPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
              +   D D  IY  VTY ++       F IN    + T+     +DRE  +  ++ + L
Sbjct: 2512 MEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVISVRL 2568

Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
            +A+D G   +   + + + DDNDN P F      V++  +   G SV++V A+D D G N
Sbjct: 2569 MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSN 2628

Query: 2102 GELVYRIEAGAQ---DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158
             ++ Y IEA ++   +   I+ ++GVI    + I  E  E +   V A D G+       
Sbjct: 2629 ADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN-EFFTFFVRAVDNGSPSKESVV 2687

Query: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218
            +V + I       P+F  P  T +V E    GT I  I A   + +  + Y +V    K 
Sbjct: 2688 LVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVLYSLV----KG 2740

Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
            +T     N++++F ++  +G + ++  ++ E    Y+ ++       D       V +  
Sbjct: 2741 NTPE--SNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDD----HEMVASVD 2794

Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL--- 2335
            +++ V D NDN+P F+    + Y   I+E    G+ +I + A D D G NG V Y+L   
Sbjct: 2795 VSIQVKDANDNSPVFES---SPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQS 2851

Query: 2336 --LDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVY-LEI 2392
              ++++    + +E    G +   + +D+E+       V ASD+G   + +   +  + +
Sbjct: 2852 QSVEVIESFAINME---TGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908

Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFA 2449
             D+ND+ P F    Y+  V ED P G +I  ++ TDADS      + Y +  GD   +FA
Sbjct: 2909 TDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968

Query: 2450 INPTTGD--IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
            +     +  +YV   LDREK+D+Y+LT  A D  G  +S        V ++VLD ND  P
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD--GTFSSK-----AIVEVKVLDANDNSP 3021

Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT 2567
               K  +S ++ E+   G  ++ + ATD D   N E+TY+L G G E F ++ D+G + T
Sbjct: 3022 VCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKT 3081

Query: 2568 QRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
              PL   E+  + L V ATDGG      + +L +E  DVNDN P F   P    + + E 
Sbjct: 3082 STPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYA--ITVFEN 3137

Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
                + +  V ATD D GLN  + YS + +A  +    F I+ +SG+IQ  + LDRE QA
Sbjct: 3138 TEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQA 3193

Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
            VY+L L A D G P        + V++ DI+DN P+F     G+      TV E    GT
Sbjct: 3194 VYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGA------TVSEDILVGT 3247

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVK 2804
             V  V  A   D   NA + Y I +GNE   F +    G + ++ +LD E    +   V+
Sbjct: 3248 EVLQVYAA-SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVE 3306

Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
            A+         G +P+L  VA      V V + DIND  P F++  YT  ++ DA +   
Sbjct: 3307 ATD--------GGTPSLSDVAT-----VNVNVTDINDNTPVFSQDTYTTVISEDAVLEQS 3353

Query: 2865 LIQVLALDADIGNNSLVFYSIL 2886
            +I V+A DAD  +NS + YSI+
Sbjct: 3354 VITVMADDADGPSNSHIHYSII 3375



 Score =  871 bits (2250), Expect = 0.0
 Identities = 844/2937 (28%), Positives = 1341/2937 (45%), Gaps = 239/2937 (8%)

Query: 12   AWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFG 68
            AW L+ +       N   F    +F   + +SED  V S + Q+ A D D  P   + + 
Sbjct: 804  AWRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYS 860

Query: 69   VSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDH-----QGVITRKVNIQVG 123
            +  +  +  F+++  TGVV + +PLDRE + E +++    D      Q   T  V + + 
Sbjct: 861  IVTDTDT--FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918

Query: 124  DVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDS 182
            DVNDN PTF    Y V++ E+ P GT I  + A DPDLG  G V YS     +  F +D 
Sbjct: 919  DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978

Query: 183  ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM--DPIFINLP 240
              G V ++++LD+E  Q Y LTV A D+ K   LS+   + + + DV +    P+F +  
Sbjct: 979  LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFV 1038

Query: 241  YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
                + E +P G+ V  ++A D+D  R   I Y+I  G+   +F +   +GV+  +  LD
Sbjct: 1039 EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098

Query: 301  RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
            RE+   SH + LTV  T    D+     +      I V D+NDNAP+ +   Y   I E 
Sbjct: 1099 REST--SH-YWLTVFAT----DQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151

Query: 361  AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
            +    ++ + I+  D D +     M+++   GN    F I P     K  +    +  LD
Sbjct: 1152 SPKDVSV-VQIEAFDPDSSSNDKLMYKI-TSGNPQGFFSIHP-----KTGLITTTSRKLD 1204

Query: 421  YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTS- 478
             E  D +  ++   ++  P     A+V + +++ENDN+P F Q  Y I L E        
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRER 1264

Query: 479  ------VLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIM---LIARLDYELIQ 527
                  +  V+ATD D G   E+SY   D  +  +F ++  TG++      A  +Y++  
Sbjct: 1265 NARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-- 1322

Query: 528  RFTLTIIARDGGGEETTGRVRINVLDVNDNVPT-----FQKDAYVGALRENEPSVTQLVR 582
               L+I A D G  + +   R+++  ++   P+     F++  +   + E++P V  ++ 
Sbjct: 1323 ---LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDP-VAHMIG 1378

Query: 583  LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
            + + +   PP   + + I   + + S+FD+   +G G I V++PLD EQ SN    LTV 
Sbjct: 1379 VISVE---PPGIPLWFDITGGN-YDSHFDVD--KGTGTIIVAKPLDAEQKSN--YNLTVE 1430

Query: 643  AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
            A D     L     V I+V D ND+ P FS   Y V + E+      +L ++A D D   
Sbjct: 1431 ATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487

Query: 703  EYGQESIIYSLEGST------QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
            +     +IY+L+ S       +FR++  +G + T+  LD E   ++ L V   D  V   
Sbjct: 1488 K-----LIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVP-- 1540

Query: 757  QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
             K   A + + + D ND+ P +  + Y   + E     S V  V A+D D G+N  ++YS
Sbjct: 1541 VKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYS 1600

Query: 817  IQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
            I+  N    + ++   G I+T    LDR N   ++      ++V  TD G PP+   +S 
Sbjct: 1601 IESGNIGNSFMIDPVLGSIKTAKE-LDRSNQAEYD------LMVKATDKGSPPMSEITSV 1653

Query: 875  TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
             +FV + D  +  P F +  +  E+ E +  G  +  V A          V Y +  G  
Sbjct: 1654 RIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNT 1706

Query: 935  RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETP 993
               F IN  SG ++T   LD E +  Y L +  ++ AG    S+ +T+ +H+ D ND  P
Sbjct: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL---STNTTVLVHLQDENDNAP 1763

Query: 994  TFFPAVYNVSVSEDVPREFRVVW-------LNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
             F  A Y   +SE       V+        +   D D   NA L Y I   +V   F++ 
Sbjct: 1764 VFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAID 1823

Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
                 + TV+ LD E T+ +   ++  D G         A V V V+D+ND  P+F +  
Sbjct: 1824 SSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPL 1883

Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
            YEAS+     +G  ++ + ATDAD   F ++ Y I  GN G  F +    G L       
Sbjct: 1884 YEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQ 1943

Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT 1226
             R R   + L V A +   G       V + V++  +    FTQ  YS + ++E +    
Sbjct: 1944 LRSR---YELTVRASD---GRFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAE 1996

Query: 1227 SVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSA 1285
            ++ V+ A      +   + Y IL+  + +F+I  ++G++ T     D E + ++ + V  
Sbjct: 1997 TLAVITAIGNPINEP--LFYHILN-PDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEV 2053

Query: 1286 TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ 1345
            T++  P       V + + ++ D A  F N  Y A +  +  +G  I  V A   D+   
Sbjct: 2054 TEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRN 2113

Query: 1346 ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREK-GDFYTLTVVADDGG-PKVDSTVK 1403
                   Y   +    F+I  + G I+++   + +     Y +TVVA DGG P   + V 
Sbjct: 2114 GEVH---YYLKEHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVI 2169

Query: 1404 VYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI 1463
            V ITV+  N   P F+    SA  I E   V   V  V+A  P+     +V +S+  G+ 
Sbjct: 2170 VPITVM--NKAMPVFEKPFYSA-EIAESIQVHSPVVHVQANSPEGL---KVFYSITDGD- 2222

Query: 1464 AGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDN 1523
               F   T N + G + V  PLD E    Y L + A+D  T    +  +  + + DINDN
Sbjct: 2223 --PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFV-DIIVDDINDN 2279

Query: 1524 PPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDR 1580
            PPV      Y V+++E    GT+VVQVRATD D   N  +SY +  GN   +   F +D 
Sbjct: 2280 PPVFAQQ-SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMF-GNHSKSHDHFHVDS 2337

Query: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
             +G I+      D E+   + +     D G PTLS+   V V + D NDN P+F+Q  YE
Sbjct: 2338 STGLISLLRTL-DYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYE 2396

Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
              + E        +  ++A D D      + Y+I++GN    F ID   G+IT +  L  
Sbjct: 2397 ARISEHAPH-GHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN-LHR 2454

Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759
                  Y+L ++ +D          S+T V V V   N + P F ++ E   E+ E  P 
Sbjct: 2455 HALKPFYSLNLSVSDGV------FRSSTQVHVTVIGGNLHSPAFLQN-EYEVELAENAPL 2507

Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIA--FY 1817
               V      D DSG  G V Y I++      F I+    +  + K   LDRET A    
Sbjct: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVI 2564

Query: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
            ++ + A+D G      T  V + + D NDN P        + I  ++   + V  VLASD
Sbjct: 2565 SVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASD 2622

Query: 1878 ADSGCNARLTFNITAGNR--ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENP 1935
            AD G NA +T+ I A +   +    IN  +G++T    L       +   +   DN    
Sbjct: 2623 ADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP- 2681

Query: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
              ++    L+ + +       P F++  Y   V E+ P GT + ++     A  +   +Y
Sbjct: 2682 --SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR----AEHSGTVLY 2735

Query: 1996 AVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL-LAEDIGLLNSTA 2053
            ++V      + +   F I+  +G + +     +D E        +L    +D   + ++ 
Sbjct: 2736 SLVKGNTPESNRDESFVIDRQSGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASV 2793

Query: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
             + I + D NDN P F  +     ++EN P G  V+Q+ A+D DSG NG+++Y ++    
Sbjct: 2794 DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQS 2853

Query: 2114 ----DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGT-VPLSGTAIVTILIDDIN 2168
                + F I++ TG I      +D E++++Y++ VVA+D G  + LS TAIV + + D+N
Sbjct: 2854 VEVIESFAINMETGWITTLKE-LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVN 2912

Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD---LNPKLEYHIVGIVAKDDTDRLVP 2225
            DS P F   I   +V E    G VIA ++  D D   +N ++ Y I G            
Sbjct: 2913 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG-----------G 2961

Query: 2226 NQEDAFAVNI--NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
            +    FAV    N   V VK P++RE    Y +T++  D              A + V V
Sbjct: 2962 DPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS--------SKAIVEVKV 3013

Query: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGY 2343
            LD NDN+P  +    T Y + I E   PG  ++ ++A D D   N  +TYTLL      +
Sbjct: 3014 LDANDNSPVCEK---TLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKF 3070

Query: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
                D+  G++  +  +D EE    +  VRA+D G   R  +  + L + D+NDN P F 
Sbjct: 3071 KLNPDT--GELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFS 3126

Query: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSS 2462
               Y   VFE+   GT++  V ATDAD+G    I YSL D  + +F+IN  +G I +   
Sbjct: 3127 ADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKP 3186

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
            LDRE +  Y L+  A D        R   +  V++ VLD+ND  P F   ++  +V E+ 
Sbjct: 3187 LDRELQAVYTLSLKAVDQG---LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243

Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
              GT V+ + A  +D   N E+TYS+  G     F +D  +G V     L  +S  ++ L
Sbjct: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
            TV ATDGG P L     + V V D+NDN PVF +    T+  I E+  L  +V  V A D
Sbjct: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV--ISEDAVLEQSVITVMADD 3361

Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
             D   N  + YS +   GN+    F IDP+ G ++  + LDRE+ + Y+L + ASD G P
Sbjct: 3362 ADGPSNSHIHYSIID--GNQG-SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSP 3418

Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
             P      + + + D++DN P+F R       Y ++ + E+ P G  V  +    D D  
Sbjct: 3419 -PRVNTTTVNIDVSDVNDNAPVFSRG-----NYSVI-IQENKPVGFSVLQLV-VTDEDSS 3470

Query: 2760 PNAIVYYF-IAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
             N   ++F I  GN+EK F + P G LL    + R+ +  +   VK + N          
Sbjct: 3471 HNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADN--------GK 3522

Query: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADI 2875
            P L   + LT  ++RV+ E I   PP     E     + +   G  + ++ A D D+
Sbjct: 3523 PQL---SSLTYIDIRVIEESI--YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV 3574



 Score =  853 bits (2204), Expect = 0.0
 Identities = 852/3035 (28%), Positives = 1375/3035 (45%), Gaps = 306/3035 (10%)

Query: 5    VATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD--- 61
            V TS   A   VL+    G  +  P FT   +       E+ P+G++V  L A D D   
Sbjct: 438  VTTSDRKASTKVLVK-VLGANSNPPEFTQTAYKA--AFDENVPIGTTVMSLSAVDPDEGE 494

Query: 62   NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE-FTVEFSVSDHQGVITRKVN- 119
            N  + + ++      F A++  TG V   + LD E     +T+    SD      R+V  
Sbjct: 495  NGYVTYSIANLNHVPF-AIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553

Query: 120  ---IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
               I + ++NDN P F        IP +  VG  I  V+A D D      V Y  +  ++
Sbjct: 554  LATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNE 611

Query: 177  --FFAIDSARGIVTVIRELDY---ETTQAYQLTVNATDQDK-TRPL---------STLAN 221
              FF+++   G++++ R L          + L + ATD +    PL           L N
Sbjct: 612  LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVN 671

Query: 222  LAIIITDVQDM-----------------DPIFIN--------------LPYSTNIYEHSP 250
            L    T V  M                 + IF +              LP    + E+ P
Sbjct: 672  LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP 731

Query: 251  PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
             G++V  + + D D G    + Y +  GN +S F +D  +G+L +   LDRE    +  +
Sbjct: 732  VGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET---TDKY 788

Query: 311  ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
             L +   +L     P  A      +++V+D NDN PEF    Y V ++E  +V   +   
Sbjct: 789  TLNITVYDLG---IPQKAA-WRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--- 841

Query: 371  IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
            IQV   D++LG N      +V +     I S T V       + +A PLD E    +   
Sbjct: 842  IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGV-------VNIARPLDRELQHEHSLK 894

Query: 431  LFANESV---PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
            + A +     P       VK++L + NDN P F  P Y + + E++  GT ++ + A D 
Sbjct: 895  IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDP 954

Query: 488  DAGTFGEVSYFFSDDPD-RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ET 543
            D G  G+V Y   D  +  F +DK +G + ++ +LD+E  Q + LT+ A+D G      +
Sbjct: 955  DLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014

Query: 544  TGRVRINVLDVNDNV--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            T  V + V+DVN+N+  P F      G ++E+ P  + ++ + A DED+  + +I YSI 
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
              S  G +    + E  GVI  S  LD E  S+   +LTV A D G  PL+S + + IEV
Sbjct: 1075 DGSGVGVF---KIGEETGVIETSDRLDRESTSH--YWLTVFATDQGVVPLSSFIEIYIEV 1129

Query: 662  FDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ-- 718
             D NDN P  S+P Y+  ++EN     +V+ + A D D S     + ++Y +  G+ Q  
Sbjct: 1130 EDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS---SNDKLMYKITSGNPQGF 1186

Query: 719  FRINARSGEITTTSL-LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
            F I+ ++G ITTTS  LDRE + E+IL V   D G     K+ IA V + +LD NDN P 
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNG--SPPKSTIARVIVKILDENDNKPQ 1244

Query: 778  WKDAPYYINLVEMTPPDSDVTT-------VVAVDPDLGENGTLVYSIQPPNKF--YSLNS 828
            +    Y I L E   PD +          V+A D D G N  + YSI+  N+   + +  
Sbjct: 1245 FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP 1304

Query: 829  TTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDND 887
             TG + +       E            + +   D GRP   +T+   + +++    +   
Sbjct: 1305 KTGVVSSKRFSAAGEYDI---------LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355

Query: 888  PTFQNLPFVAEVLEGIPA----GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSS 943
             +F+   F   V+E  P     GV   +   I L   + G        G     F ++  
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG--------GNYDSHFDVDKG 1407

Query: 944  SGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
            +G ++    LD E+ + Y L V A+D    T +  + + I V+D ND  P F  + Y V 
Sbjct: 1408 TGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYEVV 1464

Query: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVD---GKFSVGYRDAVVRTVVGLDR 1060
            + ED   E  ++ ++  D D     +L Y +          KF +      + T   LD 
Sbjct: 1465 IPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDH 1522

Query: 1061 ETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHS 1120
            E    + L +   D     KR+   A + V V D ND+ P F  SSY+  V E    G  
Sbjct: 1523 EAVHQHTLTVMVRDQDVPVKRNF--ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSV 1580

Query: 1121 ILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA 1180
            +LQ+ A D D+G+   V Y I  GN GN+F I    G + +  + LDR   + + L+V+A
Sbjct: 1581 VLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSI-KTAKELDRSNQAEYDLMVKA 1639

Query: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
             +    PM     V ++V   ++ +P FT ++YS + L ET  IG+ V +V A  + S  
Sbjct: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYS-VELSETVSIGSFVGMVTAHSQSS-- 1696

Query: 1241 GGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSV 1299
               V Y I  G  G  F+I+  +G IIT   LD+ET   Y + +  T+ A        +V
Sbjct: 1697 ---VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTN--TTV 1751

Query: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVR-------VQAYSIDNLNQITYRFNA 1352
             + L +E D A  F  A Y   I E+ ++ + ++        ++A   D  +     ++ 
Sbjct: 1752 LVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHI 1811

Query: 1353 YTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKV--DSTVKVYITVL 1409
                     F ID+ TG I     +D E+   +  TV V D G P++  +    V + V+
Sbjct: 1812 -VEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870

Query: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
            D ND  P F      A S+      G +V TV A D D+ +  Q+++S+  GNI   F +
Sbjct: 1871 DINDCPPVFAKPLYEA-SLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929

Query: 1470 VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIES 1529
               +   G + V           Y L V ASD             +T + IN    V ES
Sbjct: 1930 ---DYKTGALTVQNTTQLRS--RYELTVRASD--------GRFAGLTSVKIN----VKES 1972

Query: 1530 PFG--------YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRI 1581
                       Y+  V EN      +  + A    I  N  L Y+I   N D  F++ R 
Sbjct: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI--NEPLFYHIL--NPDRRFKISRT 2028

Query: 1582 SGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYE 1640
            SG ++T   P DRE+Q  + +V  V +E  P+  A   V V + D+NDNAP+F   P+Y 
Sbjct: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088

Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
            V+  +    +   +  + A+D D G NG V Y +   +    F+I   +G I+  K+ + 
Sbjct: 2089 VVKVD--TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQIGP-LGEISLKKQFEL 2143

Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPG 1760
            +  +  Y + V A D           +  V+V +  +N  +P F    E PF   E    
Sbjct: 2144 DTLNKEYLVTVVAKD-----GGNPAFSAEVIVPITVMNKAMPVF----EKPFYSAEIAES 2194

Query: 1761 PRVWTFLAHDRDSGPNG-QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
             +V + + H + + P G +V YSI DGDP  +F I+   GV+ V     LD E    Y L
Sbjct: 2195 IQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVI--APLDFEAHPAYKL 2252

Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
            +I A D  +    + + V I V DINDN PV       +T+SE S + + V  V A+D+D
Sbjct: 2253 SIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSD 2311

Query: 1880 SGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
            S  N  +++ +  GN  ++   F ++++TG++++ R LD E+  ++ + +   D    P 
Sbjct: 2312 SEPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGM-PT 2369

Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYA 1996
            ++     ++ + ++D NDN PLF +  Y+A + E++P G  +T +     A DAD     
Sbjct: 2370 LSSDV--IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK----AYDADSSDID 2423

Query: 1997 VVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHL 2055
             + Y +L G     F I+S+TG++T+ +   + R A  P     L L+   G+  S+  +
Sbjct: 2424 KLQYSILSGNDHKHFVIDSATGIITLSN---LHRHALKP--FYSLNLSVSDGVFRSSTQV 2478

Query: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
             +T++  N + P F      V L EN P    V++V  TD DSG+ G + Y I    A+D
Sbjct: 2479 HVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKD 2538

Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
            RF I+    +  +     +   ++   + ++A D G      T  V +++ D ND+ P+F
Sbjct: 2539 RFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQF 2596

Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
                  V++  SA  GT +  + A D D   N  + Y I     + D++ +  N E    
Sbjct: 2597 RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI-----EADSESVKENLE---- 2647

Query: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
            +N  +G +  K  +       +   +  +DN S   E  V V      V +L      P+
Sbjct: 2648 INKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLV-----YVKILPPEMQLPK 2702

Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE----D 2348
            F      +Y   + E    GT +  + A       +G V Y+L+    P   + E    D
Sbjct: 2703 FSE---PFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVID 2754

Query: 2349 SSAGKVIANRTVDYEEVHWLNFTVRAS-DNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              +G++   +++D+E   W  F++ A          A + V +++ D NDN+P+F+   Y
Sbjct: 2755 RQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPY 2814

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES-----KFAINPTTGDIYVLSS 2462
            +  + E++P G+ ++ + A+DADSG    + YSL   +S      FAIN  TG I  L  
Sbjct: 2815 EAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKE 2874

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
            LD EK+D+Y +  +A D+   +   +  ++  V + V DVND  P+F+   +  +V E++
Sbjct: 2875 LDHEKRDNYQIKVVASDHGEKI---QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD 2931

Query: 2523 PAGTSVITMMATDQD-EGPNGELTYSLEGP---GVEAFHVDMDSGLVTTQRPL--QSYEK 2576
            P G  +  +  TD D E  N ++TY + G    G  A     +   V  ++PL  +  + 
Sbjct: 2932 PQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991

Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
            + LT+ ATDG         ++ V+V+D NDN PV  +        I E++     + ++ 
Sbjct: 2992 YLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDT--IPEDVLPGKLIMQIS 3046

Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDL 2696
            ATD D   N  + Y+ L +   +    F ++P +G ++T+  LDRE QAVY L++ A+D 
Sbjct: 3047 ATDADIRSNAEITYTLLGSGAEK----FKLNPDTGELKTSTPLDREEQAVYHLLVRATDG 3102

Query: 2697 GQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDA 2756
            G          + + LED++DN P F   P        +TV E++  GTL+  V  A DA
Sbjct: 3103 GGRF---CQASIVLTLEDVNDNAPEFSADPYA------ITVFENTEPGTLLTRVQ-ATDA 3152

Query: 2757 DEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRG 2816
            D G N  + Y +    + +    +  G + + + LDRE +A+++  +KA        PR 
Sbjct: 3153 DAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGL---PRR 3209

Query: 2817 PSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIG 2876
             + T  ++  +          DIND PP F   EY A V+ D  VG+E++QV A   DI 
Sbjct: 3210 LTATGTVIVSVL---------DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIE 3260

Query: 2877 NNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
             N+ + YSI++ +     + DS+  G VF + ++D
Sbjct: 3261 ANAEITYSIISGNEHGKFSIDSK-TGAVFIIENLD 3294



 Score =  819 bits (2115), Expect = 0.0
 Identities = 791/2905 (27%), Positives = 1284/2905 (44%), Gaps = 276/2905 (9%)

Query: 93   LDRETKSEFT-VEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
            L+RE K  +T +  ++  +  V  R KV +QV D ND  P F    YSV +PENT + T 
Sbjct: 108  LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167

Query: 151  IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
            I  V+ATD D+G  G   YSF+  +  FAI    G++ +   LDY  T+ Y++ + A D+
Sbjct: 168  IARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADR 227

Query: 211  DK----TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
                  +  +S++A L + I    +  P+   +  S +  +  P      I+T  D D+G
Sbjct: 228  GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDCDQG 284

Query: 267  RPRGI-GYTIVSGN------TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
                I   +IV+G+      T   F       V  + G+    +P    G+ LT+   + 
Sbjct: 285  ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF---GYNLTL---QA 338

Query: 320  NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
             D  TP   +     ++          +F    Y   I+E A     + + ++ +    +
Sbjct: 339  KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV-VMVKAIPAYSH 397

Query: 380  LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVP 438
            L                 ++   T  + K  +     +    E V R     F  E +  
Sbjct: 398  L----------------RYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441

Query: 439  DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYF 498
            D     KV + ++  N N P F+Q  Y  +  ENV +GT+V+++ A D D G  G V+Y 
Sbjct: 442  DRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYS 501

Query: 499  FSD-DPDRFSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGG---GEETTGRVRINVLD 553
             ++ +   F++D  TG +     LDYEL+ R +TL I A D G     E      I + +
Sbjct: 502  IANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNN 561

Query: 554  VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
            +NDN P F+K    G +  +     Q+  + A D D      + Y I + +    +   S
Sbjct: 562  LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFF---S 616

Query: 614  LYEGYGVISVSRPL-DYEQISNGLIYLTVMAMDAGN--PPL--NSTVPVTIEV------- 661
            L    GV+S+ R L D          L + A D  N   PL  N TV  + ++       
Sbjct: 617  LNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEE 676

Query: 662  ---------------------------FDE---NDNPPTF-SKPAYFVSVVENIMAGATV 690
                                       FD    N + P F S     + V EN   G++V
Sbjct: 677  TGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV 736

Query: 691  LFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVR 747
            +F+N+TDLD         ++Y++ G  +   F I+  +G +   S LDRET  +Y L + 
Sbjct: 737  IFMNSTDLDTG---FNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNIT 793

Query: 748  AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
              D G+   QK     +++ ++D NDN P +    Y++ + E     S++  V A D DL
Sbjct: 794  VYDLGI--PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDL 851

Query: 808  GENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
            G NG + YSI      +S++S TG +      LDRE    H       + +   D  R  
Sbjct: 852  GPNGHVTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEH------SLKIEARDQAREE 904

Query: 868  LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
             +  S+  V V+L D+NDN PTF    +  +V E +P G  I  + A D D G +G V Y
Sbjct: 905  PQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRY 964

Query: 928  RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIHVL 986
             + +     +F ++  SG V    +LD E+   Y L V A D G P   SST  + + V+
Sbjct: 965  SL-LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVV 1023

Query: 987  DVND--ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
            DVN+    P F   V   +V ED P    V+ ++  D D   + E+ Y I  G+  G F 
Sbjct: 1024 DVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFK 1083

Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
            +G    V+ T   LDRE+T+ Y L + A D G V    +    +++ V DVNDN P   +
Sbjct: 1084 IGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPL--SSFIEIYIEVEDVNDNAPQTSE 1141

Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
              Y   + E+ P+  S++Q++A D D     ++ Y+I  GN    F IH   GL+    R
Sbjct: 1142 PVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSR 1201

Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETAG 1223
             LDRE+   H+L V   ++   P  +  RVIV + D ND  P F Q+ Y  RL  RE   
Sbjct: 1202 KLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD 1261

Query: 1224 IGTS-----VIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYL---DYE 1274
               +     +  V ATD+D G    ++Y I  G E GKF I+  TG++ +  +    +Y+
Sbjct: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD 1321

Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---EAVQFSNASYEAAILEN--LALG 1329
                 ++++ A D   P       ++I  +++     E + F  + +   ++E+  +A  
Sbjct: 1322 -----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHM 1376

Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
              ++ V+   I     I       T     + F +D  TG I V   +D E+   Y LTV
Sbjct: 1377 IGVISVEPPGIPLWFDI-------TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTV 1429

Query: 1390 VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
             A DG   +    +V+I V+D ND+ P+F  TS   V IPED      +  + A D D  
Sbjct: 1430 EATDGTTTI--LTQVFIKVIDTNDHRPQFS-TSKYEVVIPEDTAPETEILQISAVDQD-- 1484

Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
               +++++L S     + +    + + G ++ +  LD E +  + L V+  D+  P ++ 
Sbjct: 1485 EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRN 1544

Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
               + V + D ND+ P   +   Y   V E+   G+ V+QV A D+D G N+ + Y I  
Sbjct: 1545 FARIVVNVSDTNDHAPWFTAS-SYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES 1603

Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
            GN   +F +D + G I T     DR  Q+ Y L+    D+G+P +S  T V + +   ++
Sbjct: 1604 GNIGNSFMIDPVLGSIKT-AKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADN 1662

Query: 1630 NAPMFQQPHYEVLLDEGPDTLN-TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH 1688
             +P F    Y V L E     +   ++T  +         +V Y I  GN  + F I+ H
Sbjct: 1663 ASPKFTSKEYSVELSETVSIGSFVGMVTAHS-------QSSVVYEIKDGNTGDAFDINPH 1715

Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR-D 1747
             G I   K LD+E +   YTLI+  T+        L++ TTVLV++ D NDN P F + +
Sbjct: 1716 SGTIITQKALDFE-TLPIYTLIIQGTNMA-----GLSTNTTVLVHLQDENDNAPVFMQAE 1769

Query: 1748 YEGPFE--------VTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEG 1799
            Y G           V   +  P V    A D D   N  + Y I++      F I    G
Sbjct: 1770 YTGLISESASINSVVLTDRNVPLV--IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG 1827

Query: 1800 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTML--VGIRVLDINDNDPVLLNLPMN 1857
               +   + LD E  + ++ T+   D G P L +     V + V+DIND  PV       
Sbjct: 1828 A--IHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYE 1885

Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRE 1917
             ++   +     V  V A+DADS   ++L ++IT GN    F ++  TG +TV       
Sbjct: 1886 ASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLR 1945

Query: 1918 RIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP 1977
                Y+LT+   D     R A      + I + +  ++H  FT+  Y A V ENS     
Sbjct: 1946 --SRYELTVRASDG----RFA--GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAET 1997

Query: 1978 LTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPIL 2037
            L V+            I   + Y +L      F I+ ++GV++  +G   DRE       
Sbjct: 1998 LAVITA------IGNPINEPLFYHILNPDR-RFKISRTSGVLST-TGTPFDRE--QQEAF 2047

Query: 2038 ELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATD 2095
            ++++   +    ++ AH+++ ++  D NDN P F        +  +   G  +  VTA D
Sbjct: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107

Query: 2096 EDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLS 2155
             DSG NGE+ Y ++    + F I  +  +       +D   +E Y +TVVA D G    S
Sbjct: 2108 RDSGRNGEVHYYLKE-HHEHFQIGPLGEISLKKQFELDTLNKE-YLVTVVAKDGGNPAFS 2165

Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIV 2215
               IV I +  +N + P F  P  +  + ES +  + + ++ A   +   K+ Y I    
Sbjct: 2166 AEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSIT--- 2219

Query: 2216 AKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
               D D         F +N NTG + V +P++ E    Y++++   D        S++  
Sbjct: 2220 ---DGDPF-----SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATD--------SLTGA 2263

Query: 2276 NAKLTVNVL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
            +A++ V+++  D+NDN P F       Y   + E +  GT+++ V A D D   N  ++Y
Sbjct: 2264 HAEVFVDIIVDDINDNPPVFAQ---QSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISY 2320

Query: 2334 TLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
             +       +     DSS G +   RT+DYE+       VRA D G P  ++++ V +++
Sbjct: 2321 QMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDV 2380

Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAI 2450
             D+NDN P+F+Q  Y+  + E  P G  +  V A DADS +   ++YS+  G+    F I
Sbjct: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVI 2440

Query: 2451 NPTTGDIYVLSSLDREK-KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
            +  TG I  LS+L R   K  Y L          V+     +S QV + V+  N   P F
Sbjct: 2441 DSATG-IITLSNLHRHALKPFYSLNL-------SVSDGVFRSSTQVHVTVIGGNLHSPAF 2492

Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQ 2568
             + ++   + EN P  T V+ +  TD D G  G +TY +      + F+++    + T +
Sbjct: 2493 LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLE 2552

Query: 2569 ---RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
               R   + +  S+ ++A D G    + T  ++  + D NDN P F        ++I   
Sbjct: 2553 KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI--LTDDNDNAPQF--RATKYEVNIGSS 2608

Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
                ++V +V A+D DEG N  + Y+ ++       E   I+ +SG+I T + L      
Sbjct: 2609 AAKGTSVVKVLASDADEGSNADITYA-IEADSESVKENLEINKLSGVITTKESLIGLENE 2667

Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
             ++  + A D G P   E++  + V +       P  ++ PK S  +   TV E  P GT
Sbjct: 2668 FFTFFVRAVDNGSP-SKESVVLVYVKI------LPPEMQLPKFSEPFYTFTVSEDVPIGT 2720

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAA----GNEEKNFHL-QPDGCLLVLRDLDREREAIFS 2800
             +  +       E    ++Y  +       N +++F + +  G L + + LD E    + 
Sbjct: 2721 EIDLIRA-----EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQ 2775

Query: 2801 FIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAK 2860
            F + A         R      ++VA +   +V + ++D ND  P F  + Y A +  +  
Sbjct: 2776 FSILA---------RCTQDDHEMVASV---DVSIQVKDANDNSPVFESSPYEAFIVENLP 2823

Query: 2861 VGSELIQVLALDADIGNNSLVFYSI 2885
             GS +IQ+ A DAD G N  V YS+
Sbjct: 2824 GGSRVIQIRASDADSGTNGQVMYSL 2848



 Score =  769 bits (1985), Expect = 0.0
 Identities = 791/2831 (27%), Positives = 1265/2831 (44%), Gaps = 289/2831 (10%)

Query: 236  FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIF-ALDYISG-- 291
            F +L Y+  + E+S   T V     +      P   + Y IVSG++ ++F A +YI G  
Sbjct: 34   FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93

Query: 292  ----VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
                + T  G     N      + L VK  E N     ++    T   + V+D ND  P 
Sbjct: 94   CFLRIRTKGGNTAILNREVKDHYTLIVKALEKN-----TNVEARTKVRVQVLDTNDLRPL 148

Query: 348  FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
            F+ + YSV++ E   +  ++    +V   D ++G N  F  Y   + +  F I PTS   
Sbjct: 149  FSPTSYSVSLPENTAIRTSIA---RVSATDADIGTNGEF-YYSFKDRTDMFAIHPTSGV- 203

Query: 408  KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVG------YAKVKITLINENDNRPIFS 461
                 I +   LDY     Y+ ++ A +      G       AK+ + +   N+  P+ +
Sbjct: 204  -----IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVIT 258

Query: 462  QPLYNISLYENVTVGTSVLTVLATDNDA-GTFGEVSYFFSDDPDRFSLDKDTG-----LI 515
                + S  +      +++TV   D  A G    +S    D   +F   +         +
Sbjct: 259  AVTLSPSELDR-DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKV 317

Query: 516  MLIARLDYELIQ-RFTLTIIARDGGGEETTGRVRINVL---DVNDNVPTFQKDAYVGALR 571
              I  +D++     + LT+ A+D G       V++  +           F+KD Y   + 
Sbjct: 318  KAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEIS 377

Query: 572  ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
            E  P  T +V ++A     P  + + Y   S      +   SL    G+IS+  P+  +Q
Sbjct: 378  EFAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKF---SLNYNTGLISILEPVKRQQ 430

Query: 632  ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
             ++  + +T     A       +  V ++V   N NPP F++ AY  +  EN+  G TV+
Sbjct: 431  AAHFELEVTTSDRKA-------STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483

Query: 692  FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE-YILIVRAVD 750
             L+A D D   E G  +   +      F I+  +G ++T+  LD E     Y L +RA D
Sbjct: 484  SLSAVDPDEG-ENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASD 542

Query: 751  GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD----SDVTTVVAVDPD 806
             G+ + ++  +    ITL ++NDN P ++     IN     P D      +TTV A+D D
Sbjct: 543  WGLPYRREVEVLAT-ITLNNLNDNTPLFEK----INCEGTIPRDLGVGEQITTVSAIDAD 597

Query: 807  LGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLD--------------RENPDPHEA 850
              E   + Y I+  N+  F+SLN  +G +    +++D                + +    
Sbjct: 598  --ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655

Query: 851  ELMRKIVVSVT---------DCGRPPLKATSSAT------------VFVNLLDLNDNDPT 889
             L   I V+ +         + G   + A                 +F +   +N + P 
Sbjct: 656  PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715

Query: 890  FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
            F++ LP   +V E  P G S+  + + DLD G NG + Y +  G     F+I+  +G++ 
Sbjct: 716  FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLK 775

Query: 949  TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
              + LDRE   +Y L +   D G P K++   L + V+D ND  P F    Y V VSED 
Sbjct: 776  ILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDK 835

Query: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML 1068
                 ++ +  TD D+G N  ++Y I        FS+     VV     LDRE    + L
Sbjct: 836  EVHSEIIQVEATDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSL 893

Query: 1069 ILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATD 1128
             +EA D      +   T  V V++ DVNDN P F+  +Y   V ED+PEG  I+ L+A D
Sbjct: 894  KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHD 953

Query: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGP- 1187
             D G+ G+V Y +L    GN F +   +G + R  + LD E+   + L V A   D G  
Sbjct: 954  PDLGQSGQVRYSLLDHGEGN-FDVDKLSGAV-RIVQQLDFEKKQVYNLTVRA--KDKGKP 1009

Query: 1188 --MRSSVRVIVYVEDINDEA--PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
              + S+  V V V D+N+    PVF+     +  ++E A +G+ V+ V A D D+   G 
Sbjct: 1010 VSLSSTCYVEVEVVDVNENLHPPVFSSF-VEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068

Query: 1244 VNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
            + Y I  G+  G F+I E TG+I T + LD E+ + Y + V ATDQ       F  +YI 
Sbjct: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128

Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALF 1362
            + +  D A Q S   Y   I+EN      +V+++A+  D+ +     +   TS   +  F
Sbjct: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKI-TSGNPQGFF 1187

Query: 1363 KIDAITGVITVQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDF 1420
             I   TG+IT     +DRE+ D + L V V D+G P   +  +V + +LDENDN P+F  
Sbjct: 1188 SIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF-L 1246

Query: 1421 TSDSAVSIPE-DCPVGQRVAT------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473
                 + +PE + P  +R A       V A D D G N ++ +S+  GN  G F I    
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFI---E 1303

Query: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE----- 1528
               G V   R     E D  IL + A D G P  +K    ++ I  I+   P +E     
Sbjct: 1304 PKTGVVSSKRFSAAGEYD--ILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPISFE 1359

Query: 1529 -SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
             S F + V  ++ V     V+ V       GI   L + IT GN D  F +D+ +G I  
Sbjct: 1360 ESFFTFTVMESDPVAHMIGVISVEPP----GIP--LWFDITGGNYDSHFDVDKGTGTIIV 1413

Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
               P D E++S Y+L     D GT T+   T V++ ++D ND+ P F    YEV++ E  
Sbjct: 1414 AK-PLDAEQKSNYNLTVEATD-GTTTI--LTQVFIKVIDTNDHRPQFSTSKYEVVIPE-- 1467

Query: 1648 DTL-NTSLITIQALDLDEGPNGTVTYAIVAGN---IVNTFRIDRHMGVITAAKELDYEIS 1703
            DT   T ++ I A+D DE     + Y + +      +  FR+D   G +  +++LD+E  
Sbjct: 1468 DTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525

Query: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
            H ++TL V   DQ   +         ++VNV+D ND+ P F               G  V
Sbjct: 1526 H-QHTLTVMVRDQDVPVKRNFAR---IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581

Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
                A D+D G N +V YSI  G+    F+I PV G ++  K  ELDR   A Y+L + A
Sbjct: 1582 LQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAK--ELDRSNQAEYDLMVKA 1639

Query: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
             D+G PP+S    V I V   ++  P   +   ++ +SE   + SFV  V A    S   
Sbjct: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS--- 1696

Query: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
              + + I  GN   AF IN  +G +   + LD E +P Y L I   +             
Sbjct: 1697 --VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTN-----MAGLSTNT 1749

Query: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP-LTVLNGPIL--ALDADQDIYAVVTY 2000
             +L+ L DENDN P+F ++ Y   + E++   +  LT  N P++  A DAD+D  A++ Y
Sbjct: 1750 TVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY 1809

Query: 2001 QLLGAQ-SGLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAH 2054
             ++       F I+SSTG + TV S   +D E  S  I    +   D+G         A+
Sbjct: 1810 HIVEPSVHTYFAIDSSTGAIHTVLS---LDYEETS--IFHFTVQVHDMGTPRLFAEYAAN 1864

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQ 2113
            + + ++D ND  P F+       LL     G  V+ V ATD DS    +L+Y I E    
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIG 1924

Query: 2114 DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPE 2173
            ++F +   TG + V N T   + +  Y LTV A+D      +G   V I + +  +S  +
Sbjct: 1925 EKFSMDYKTGALTVQNTT---QLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978

Query: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV 2233
            F   + +  V E++     +A ITAI + +N  L YHI+             N +  F +
Sbjct: 1979 FTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHIL-------------NPDRRFKI 2025

Query: 2234 NINTGSVMVK-SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
            +  +G +    +P +RE    ++V + V +       +  +V +  + V V D NDN P 
Sbjct: 2026 SRTSGVLSTTGTPFDREQQEAFDVVVEVTEE-----HKPSAVAHVVVKVIVEDQNDNAPV 2080

Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD------LVPPGYVQL 2346
            F    + YY   +      G  +  V AVD D G NG V Y L +      + P G + L
Sbjct: 2081 F--VNLPYYAV-VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISL 2137

Query: 2347 EDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPS 2406
            +     K     T++ E +     TV A D G+P  +AE+ V + ++  N   P+F++P 
Sbjct: 2138 K-----KQFELDTLNKEYL----VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF 2186

Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLD 2464
            Y   + E + V + ++ V A   +      + YS+ DG+  S+F IN  TG I V++ LD
Sbjct: 2187 YSAEIAESIQVHSPVVHVQANSPEG---LKVFYSITDGDPFSQFTINFNTGVINVIAPLD 2243

Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
             E    Y L+  A D+   +     E  V +++   D+ND  P F++  ++ ++ E    
Sbjct: 2244 FEAHPAYKLSIRATDS---LTGAHAEVFVDIIVD--DINDNPPVFAQQSYAVTLSEASVI 2298

Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSL 2579
            GTSV+ + ATD D  PN  ++Y + G   ++   FHVD  +GL++  R L  +   + ++
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTI 2358

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
             V A DGG P L    ++ V+V D+NDN P+F +        I E  P    V  V A D
Sbjct: 2359 FVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYD 2416

Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
             D      ++YS L  +GN D + F+ID  +G+I  +       +  YSL L  SD    
Sbjct: 2417 ADSSDIDKLQYSIL--SGN-DHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD---- 2469

Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
              + +   + V +   + + P F++      +Y++  + E++P  TLV  V    D D G
Sbjct: 2470 GVFRSSTQVHVTVIGGNLHSPAFLQN-----EYEV-ELAENAPLHTLVMEVK-TTDGDSG 2522

Query: 2760 PNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP 2819
                V Y I     +  F++   G +  L  LDRE  A     V+  +            
Sbjct: 2523 IYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAK----------- 2571

Query: 2820 TLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNS 2879
              D    +    V V+L D ND  P+F   +Y   + + A  G+ +++VLA DAD G+N+
Sbjct: 2572 --DAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNA 2629

Query: 2880 LVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAG 2939
             + Y+I A         DSE V +   +  + G++ T +  +     +F   + A D   
Sbjct: 2630 DITYAIEA---------DSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2680

Query: 2940 HNDTAIIGIYI 2950
             +  +++ +Y+
Sbjct: 2681 PSKESVVLVYV 2691



 Score =  753 bits (1943), Expect = 0.0
 Identities = 783/2952 (26%), Positives = 1295/2952 (43%), Gaps = 282/2952 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPLDR 95
            + E+T + +S+ ++ A D D      G +GE      + +  FA+ P +GV+ L   LD 
Sbjct: 158  LPENTAIRTSIARVSATDAD-----IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDY 212

Query: 96   ETKSEFTVEFSVSDH-------QGVIT-RKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
                 + +E   +D         G+ +  K+ + +   N+ AP       S   P     
Sbjct: 213  LETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLS---PSELDR 269

Query: 148  GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYETTQ 199
                 IV   D D GA G +    + +     QF  + S  G     V  I  +D+++  
Sbjct: 270  DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329

Query: 200  -AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
              Y LT+ A D+      S++  + +     +     F    Y   I E +PP T V ++
Sbjct: 330  FGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMV 389

Query: 259  TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
             AI         + Y   S    + F+L+Y +G++++   + R+   +   F L V    
Sbjct: 390  KAIPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH---FELEV---- 438

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
                 T SD   +T   + V+  N N PEF  + Y  A  E   +G  + + +  VD DE
Sbjct: 439  -----TTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTV-MSLSAVDPDE 492

Query: 379  NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESV 437
                 + +  Y + N +H     P ++       +  +  LDYE + R Y   + A++  
Sbjct: 493  G---ENGYVTYSIANLNH----VPFAIDHFTG-AVSTSENLDYELMPRVYTLRIRASDWG 544

Query: 438  PDHVGYAKV--KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
              +    +V   ITL N NDN P+F +     ++  ++ VG  + TV A D D     + 
Sbjct: 545  LPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQY 604

Query: 496  SYFFSDDPDRFSLDKDTGLIMLIARLDYEL---IQRFTLTIIARDGGGEETTGRVRINVL 552
                 ++ D FSL+ ++G++ L   L   L   +   +L I A DG    T   + I V 
Sbjct: 605  QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664

Query: 553  -------------------------------------------DVNDNVPTFQKDAYVG- 568
                                                        VN ++P F+     G 
Sbjct: 665  ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724

Query: 569  ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
             ++EN+P  + ++ + +TD D+  N ++ Y+ VS     S F I +    G++ +  PLD
Sbjct: 725  QVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGNEDSCFMIDMET--GMLKILSPLD 781

Query: 629  YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
             E      + +TV   D G P   +   + + V D NDNPP F + +YFV V E+    +
Sbjct: 782  RETTDKYTLNITV--YDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHS 839

Query: 689  TVLFLNATDLDRSREYGQESIIYSLEGSTQ-FRINARSGEITTTSLLDRETKSEYILIVR 747
             ++ + ATD D         + YS+   T  F I++ +G +     LDRE + E+ L + 
Sbjct: 840  EIIQVEATDKDLG---PNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIE 896

Query: 748  AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
            A D      Q      V ++L D+NDN PT+    Y + + E  P  + +  + A DPDL
Sbjct: 897  ARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL 956

Query: 808  GENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
            G++G + YS+    +  + ++  +G +R    +         E + +  + V   D G+ 
Sbjct: 957  GQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQL-------DFEKKQVYNLTVRAKDKGK- 1008

Query: 867  PLKATSSATVFVNLLDLNDN--DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGL 924
            P+  +S+  V V ++D+N+N   P F +      V E  P G  +  V A D D   +G 
Sbjct: 1009 PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068

Query: 925  VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
            + Y +  G     F I   +GV+ T+  LDRE  + Y L V A+D G    SS   + I 
Sbjct: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128

Query: 985  VLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
            V DVND  P     VY   + E+ P++  VV +   D D   N +L Y IT GN  G FS
Sbjct: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFS 1188

Query: 1045 VGYRDAVVRTVV-GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFL 1103
            +  +  ++ T    LDRE    ++L +   DNG   K  +  A V V +LD NDN+P FL
Sbjct: 1189 IHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPK--STIARVIVKILDENDNKPQFL 1246

Query: 1104 QSSYEASVPE-DIPE------GHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSN 1156
            Q  Y+  +PE + P+         +  + ATD DEG    + Y I  GN    F I    
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKT 1306

Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE----APVFTQQQ 1212
            G++         E +   +L ++A   D G  + S    +++E I+       P+  ++ 
Sbjct: 1307 GVVSSKRFSAAGEYD---ILSIKAV--DNGRPQKSSTTRLHIEWISKPKPSLEPISFEES 1361

Query: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA--EGKFEIDESTGLIITVNY 1270
            +    + E+  +   + V+          G+  +  ++G   +  F++D+ TG II    
Sbjct: 1362 FFTFTVMESDPVAHMIGVISVE-----PPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416

Query: 1271 LDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGT 1330
            LD E K++Y + V ATD           V+I +++  D   QFS + YE  I E+ A  T
Sbjct: 1417 LDAEQKSNYNLTVEATDGTTTI---LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPET 1473

Query: 1331 EIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV- 1389
            EI+++ A   D  N++ Y   +     +   F++D  TG +     +D E    +TLTV 
Sbjct: 1474 EILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533

Query: 1390 VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
            V D   P   +  ++ + V D ND++P F  +S     + E   VG  V  V A D D G
Sbjct: 1534 VRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG-RVYESAAVGSVVLQVTALDKDKG 1592

Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
             N +V++S+ SGNI  +F I   +  +G +  A+ LDR     Y L V A+D+G+PP  +
Sbjct: 1593 KNAEVLYSIESGNIGNSFMI---DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649

Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
               +++ +   ++  P   S   Y+V ++E V  G+ V  V A  +     S + Y I +
Sbjct: 1650 ITSVRIFVTIADNASPKFTSK-EYSVELSETVSIGSFVGMVTAHSQ-----SSVVYEIKD 1703

Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
            GN   AF ++  SG I T+ A  D E    Y L+  ++      LS  T V V + DEND
Sbjct: 1704 GNTGDAFDINPHSGTIITQKA-LDFETLPIYTLI--IQGTNMAGLSTNTTVLVHLQDEND 1760

Query: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLIT-------IQALDLDEGPNGTVTYAIVAGNIVNT 1682
            NAP+F Q  Y  L+ E   ++N+ ++T       I+A D D+  N  + Y IV  ++   
Sbjct: 1761 NAPVFMQAEYTGLISESA-SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTY 1819

Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
            F ID   G I     LDYE +   +  +       P L     +  T  V+V DIND  P
Sbjct: 1820 FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVT--VHVIDINDCPP 1877

Query: 1743 TFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLR 1802
             F +       +     G +V T  A D DS    Q+ YSI +G+   +F +    G L 
Sbjct: 1878 VFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT 1937

Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
            V+   +L       Y LT+ A D     L+S   V I V +  ++         +  + E
Sbjct: 1938 VQNTTQLRSR----YELTVRASDGRFAGLTS---VKINVKESKESHLKFTQDVYSAVVKE 1990

Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV-TVNRPLDRERIPE 1921
            NS  +  +A + A    +  N  L ++I   N +R F I+ T+G++ T   P DRE+   
Sbjct: 1991 NSTEAETLAVITA--IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEA 2046

Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
            + + + V +  +   +A   + ++ + + D+NDN P+F    Y A V  ++  G  +   
Sbjct: 2047 FDVVVEVTEEHKPSAVA---HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRY- 2102

Query: 1982 NGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
               + A+D D      V Y L       F I    G ++++    +D    +   L + +
Sbjct: 2103 ---VTAVDRDSGRNGEVHYYLKEHHEH-FQI-GPLGEISLKKQFELD--TLNKEYL-VTV 2154

Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
            +A+D G    +A +++ I   N   P F     +  + E+      V+ V A   + GL 
Sbjct: 2155 VAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GL- 2212

Query: 2102 GELVYRIEAGAQ-DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
             ++ Y I  G    +F I+  TGVI V  A +D E   +Y+L++ ATD  T        V
Sbjct: 2213 -KVFYSITDGDPFSQFTINFNTGVINV-IAPLDFEAHPAYKLSIRATDSLT-GAHAEVFV 2269

Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPK--LEYHIVGIVAKD 2218
             I++DDIND+ P F      V++ E++  GT +  + A D D  P   + Y + G  +K 
Sbjct: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK- 2328

Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
                      D F V+ +TG + +   ++ E    + + +  +D    +P  S  V    
Sbjct: 2329 --------SHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGG--MPTLSSDV---I 2375

Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 2338
            +TV+V D+NDN P F+      Y  RI E A  G  +  V A D D      + Y++L  
Sbjct: 2376 VTVDVTDLNDNPPLFEQ---QIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432

Query: 2339 VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDN 2398
                +  + DS+ G +  +    +    + +  +  SD       +   V++ ++  N +
Sbjct: 2433 NDHKHFVI-DSATGIITLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLH 2488

Query: 2399 NPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD--GESKFAINPTTGD 2456
            +P F Q  Y+  + E+ P+ T+++ V  TD DSG +  + Y + +   + +F IN   G 
Sbjct: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQ 2547

Query: 2457 IYVLSSLDREKKDHYILTA--LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF 2514
            I+ L  LDRE     +++   +AKD  G VA         V + + D ND  PQF   ++
Sbjct: 2548 IFTLEKLDRETPAEKVISVRLMAKDAGGKVA------FCTVNVILTDDNDNAPQFRATKY 2601

Query: 2515 STSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG---VEAFHVDMDSGLVTTQRPL 2571
              ++  +   GTSV+ ++A+D DEG N ++TY++E       E   ++  SG++TT+  L
Sbjct: 2602 EVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESL 2661

Query: 2572 QSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR 2629
               E   F+  V A D G P      ++ V+++      P F  P       + E++P+ 
Sbjct: 2662 IGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEP--FYTFTVSEDVPIG 2719

Query: 2630 SNVYEVYATDKDEGLNGAVRYSFLK---TAGNRDWEFFIIDPISGLIQTAQRLDRESQAV 2686
            + +  + A       +G V YS +K      NRD E F+ID  SG ++  + LD E+   
Sbjct: 2720 TEIDLIRAEH-----SGTVLYSLVKGNTPESNRD-ESFVIDRQSGRLKLEKSLDHETTKW 2773

Query: 2687 YSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
            Y   ++A              + + ++D +DN P+F   P     Y+   V E+ P G+ 
Sbjct: 2774 YQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSP-----YEAFIV-ENLPGGSR 2827

Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNEE---KNFHLQPD-GCLLVLRDLDREREAIFSFI 2802
            V  +  A DAD G N  V Y +         ++F +  + G +  L++LD E+   +   
Sbjct: 2828 VIQIR-ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIK 2886

Query: 2803 VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVG 2862
            V AS +       G    L   A      V V + D+ND PPRFT   Y   V+ D   G
Sbjct: 2887 VVASDH-------GEKIQLSSTA-----IVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG 2934

Query: 2863 SELIQVLALDAD 2874
              +  +   DAD
Sbjct: 2935 GVIAILSTTDAD 2946



 Score =  639 bits (1649), Expect = 0.0
 Identities = 603/2160 (27%), Positives = 977/2160 (45%), Gaps = 165/2160 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            + E   VGS V Q+ A D D   N  +++ +        F ++P  G +   + LDR  +
Sbjct: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQ 1630

Query: 99   SEFTVEFSVSDH----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
            +E+ +    +D        IT  V I V   ++ +P F ++ YSV + E   +G+ + +V
Sbjct: 1631 AEYDLMVKATDKGSPPMSEIT-SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689

Query: 155  NATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
             A         SV+Y  +  +    F I+   G +   + LD+ET   Y L +  T+   
Sbjct: 1690 TAHSQS-----SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM-- 1742

Query: 213  TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR-------IITAIDQDK 265
               LST   + + + D  D  P+F+   Y+  I E +   + V        +I A D DK
Sbjct: 1743 -AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK 1801

Query: 266  GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
                 + Y IV  + ++ FA+D  +G +     LD E     H    TV+  ++   R  
Sbjct: 1802 DSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFH---FTVQVHDMGTPRLF 1858

Query: 326  SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
            ++     T +  VIDIND  P F    Y  ++      G  + + +   D D +     +
Sbjct: 1859 AEYAANVTVH--VIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDADSSAFSQLI 1915

Query: 386  FEVYLVGNNSHHFIIS----PTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
            + +   GN    F +       +VQ    +R R      YE   R     FA        
Sbjct: 1916 YSI-TEGNIGEKFSMDYKTGALTVQNTTQLRSR------YELTVRASDGRFA-------- 1960

Query: 442  GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
            G   VKI +    ++   F+Q +Y+  + EN T   ++  + A  N      E  ++   
Sbjct: 1961 GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP---INEPLFYHIL 2017

Query: 502  DPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDN 557
            +PDR F + + +G++       D E  + F + +   +         V + V+  D NDN
Sbjct: 2018 NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDN 2077

Query: 558  VPTFQKDAYVGALRENEPSVTQLVR-LRATDEDSPPNNQITYSIVSASAFGSYFDISLYE 616
             P F    Y   ++  +  V  ++R + A D DS  N ++ Y +        +F I    
Sbjct: 2078 APVFVNLPYYAVVKV-DTEVGHVIRYVTAVDRDSGRNGEVHYYL---KEHHEHFQIG--- 2130

Query: 617  GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAY 676
              G IS+ +  + + ++   + +TV+A D GNP  ++ V V I V   N   P F KP Y
Sbjct: 2131 PLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFY 2187

Query: 677  FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS---TQFRINARSGEITTTSL 733
               + E+I   + V+ + A   +  +      + YS+      +QF IN  +G I   + 
Sbjct: 2188 SAEIAESIQVHSPVVHVQANSPEGLK------VFYSITDGDPFSQFTINFNTGVINVIAP 2241

Query: 734  LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
            LD E    Y L +RA D   G + +     V+I + DINDN P +    Y + L E +  
Sbjct: 2242 LDFEAHPAYKLSIRATDSLTGAHAEV---FVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298

Query: 794  DSDVTTVVAVDPDLGENGTLVYSI----QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHE 849
             + V  V A D D   N  + Y +       +  + ++S+TG I      LD E    H 
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT-LDYEQSRQHT 2357

Query: 850  AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
                  I V   D G P L  +S   V V++ DLNDN P F+   + A + E  P G  +
Sbjct: 2358 ------IFVRAVDGGMPTL--SSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFV 2409

Query: 910  YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE-YQLRVVAS 968
              V A D D      + Y +  G     F+I+S++G++ T + L R  +   Y L +  S
Sbjct: 2410 TCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVS 2468

Query: 969  DAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
            D       S++ + + V+  N  +P F    Y V ++E+ P    V+ +  TD D G+  
Sbjct: 2469 DG---VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYG 2525

Query: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATV 1088
             ++Y I       +F +  R  +  T+  LDRET A  ++ +  +     GK      TV
Sbjct: 2526 HVTYHIVNDFAKDRFYINERGQIF-TLEKLDRETPAEKVISVRLMAKDAGGK--VAFCTV 2582

Query: 1089 FVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG- 1147
             V + D NDN P F  + YE ++     +G S++++ A+DADEG    + Y I   +   
Sbjct: 2583 NVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642

Query: 1148 -NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEA- 1205
              N  I+  +G++      +  E N      V A ++   P + SV V+VYV+ +  E  
Sbjct: 2643 KENLEINKLSGVITTKESLIGLE-NEFFTFFVRAVDNG-SPSKESV-VLVYVKILPPEMQ 2699

Query: 1206 -PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG------AEGKFEI 1258
             P F++  Y+   + E   IGT + +++A        G V Y ++ G       +  F I
Sbjct: 2700 LPKFSEPFYT-FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVI 2753

Query: 1259 DESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ-GFCSVYITLLNELDEAVQFSNAS 1317
            D  +G +     LD+ET   Y  ++ A              V I + +  D +  F ++ 
Sbjct: 2754 DRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSP 2813

Query: 1318 YEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQG 1375
            YEA I+ENL  G+ +++++A   D+    Q+ Y  +   S +    F I+  TG IT   
Sbjct: 2814 YEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLK 2873

Query: 1376 LVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
             +D EK D Y + VVA D G K+   ST  V +TV D ND+ PRF        ++ ED P
Sbjct: 2874 ELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKG-TVSEDDP 2932

Query: 1434 VGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDH 1492
             G  +A +   D D+   N QV + +  G+  G F + T  +   +V+V +PLDRE+ D+
Sbjct: 2933 QGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLDREKRDN 2991

Query: 1493 YILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
            Y+L + A+D GT   K   I++V +LD NDN PV E    Y+ ++ E+V  G  ++Q+ A
Sbjct: 2992 YLLTITATD-GTFSSKA--IVEVKVLDANDNSPVCEKTL-YSDTIPEDVLPGKLIMQISA 3047

Query: 1553 TDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP 1612
            TD DI  N+ ++Y +  G+    F+++  +GE+ T   P DRE Q+ YHL+    D G  
Sbjct: 3048 TDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTS-TPLDREEQAVYHLLVRATDGGGR 3105

Query: 1613 TLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY 1672
               A+  + +T+ D NDNAP F    Y + + E  +   T L  +QA D D G N  + Y
Sbjct: 3106 FCQAS--IVLTLEDVNDNAPEFSADPYAITVFENTEP-GTLLTRVQATDADAGLNRKILY 3162

Query: 1673 AIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLV 1732
            +++  +    F I+   G+I   K LD E+    YTL + A DQ   L  RLT+T TV+V
Sbjct: 3163 SLI-DSADGQFSINELSGIIQLEKPLDRELQ-AVYTLSLKAVDQG--LPRRLTATGTVIV 3218

Query: 1733 NVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEF 1792
            +V DINDN P F     G     +   G  V    A  RD   N ++ YSI+ G+  G+F
Sbjct: 3219 SVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKF 3278

Query: 1793 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852
             I    G + + ++  LD E+   Y LT+ A D G P LS    V + V DINDN PV  
Sbjct: 3279 SIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336

Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNR 1912
                   ISE++ +   V  V+A DAD   N+ + ++I  GN+  +F I+   G V V +
Sbjct: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK 3396

Query: 1913 PLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
             LDRE I  Y LT+   DN   PR+   +   + I +SD NDN P+F++  Y   + EN 
Sbjct: 3397 LLDRETISGYTLTVQASDNGSPPRV---NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENK 3453

Query: 1973 PAGTPLTVLNGPILALDADQD----IYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIID 2028
            P G   +VL   +   D+  +     + +VT    G     F++N   GV+   S   I 
Sbjct: 3454 PVG--FSVLQLVVTDEDSSHNGPPFFFTIVT----GNDEKAFEVNPQ-GVLLTSSA--IK 3504

Query: 2029 REAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV 2088
            R+     +L++ +       L+S  ++ I +++++   P   P  + +        G  +
Sbjct: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564

Query: 2089 LQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148
             ++ ATD+D  +   L Y ++    + F +    G + + +  +D  +   Y L V  TD
Sbjct: 3565 GKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKL-IAHKKLDIGQ---YLLNVSVTD 3618



 Score =  473 bits (1218), Expect = e-132
 Identities = 383/1288 (29%), Positives = 605/1288 (46%), Gaps = 86/1288 (6%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTG 85
            P F    ++    ISE  P G  VT + A D D+   D L + +      + F ++  TG
Sbjct: 2388 PLFEQQIYEAR--ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG 2445

Query: 86   VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
            ++ L        K  +++  SVSD     + +V++ V   N ++P F    Y V + EN 
Sbjct: 2446 IITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505

Query: 146  PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID----SARGIVTVIRELDYETTQAY 201
            P+ T +  V  TD D G  G V Y        FA D    + RG +  + +LD ET    
Sbjct: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVND---FAKDRFYINERGQIFTLEKLDRETPAEK 2562

Query: 202  QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
             ++V    +D    ++    + +I+TD  D  P F    Y  NI   +  GT+V  + A 
Sbjct: 2563 VISVRLMAKDAGGKVA-FCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621

Query: 262  DQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLN-GLLDRENPLYSHGFILTVKGTE 318
            D D+G    I Y I   S +      ++ +SGV+T    L+  EN  ++  F+  V    
Sbjct: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF-FVRAV---- 2676

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
              D+ +PS  +V   + + ++      P+F+   Y+  ++E   +G  + L      + E
Sbjct: 2677 --DNGSPSKESVVLVY-VKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI-----RAE 2728

Query: 379  NLGLNSMFEVY-LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
            + G      +Y LV  N+       + V  +   R+++   LD+ET   Y F + A  + 
Sbjct: 2729 HSGT----VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784

Query: 438  PDH--VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
             DH  V    V I + + NDN P+F    Y   + EN+  G+ V+ + A+D D+GT G+V
Sbjct: 2785 DDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQV 2844

Query: 496  SYFFSDDP-----DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ETTGRV 547
             Y           + F+++ +TG I  +  LD+E    + + ++A D G +    +T  V
Sbjct: 2845 MYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIV 2904

Query: 548  RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP-NNQITYSIVSASAF 606
             + V DVND+ P F  + Y G + E++P    +  L  TD DS   N Q+TY I      
Sbjct: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964

Query: 607  GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEND 666
            G  F +   +    + V +PLD E+  N L  LT+ A D      +S   V ++V D ND
Sbjct: 2965 GQ-FAVETIQNEWKVYVKKPLDREKRDNYL--LTITATDG---TFSSKAIVEVKVLDAND 3018

Query: 667  NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS--TQFRINAR 724
            N P   K  Y  ++ E+++ G  ++ ++ATD D         I Y+L GS   +F++N  
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIR---SNAEITYTLLGSGAEKFKLNPD 3075

Query: 725  SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
            +GE+ T++ LDRE ++ Y L+VRA DGG    Q    A++ +TL D+NDN P +   PY 
Sbjct: 3076 TGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ----ASIVLTLEDVNDNAPEFSADPYA 3131

Query: 785  INLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRE 843
            I + E T P + +T V A D D G N  ++YS I   +  +S+N  +G I+        E
Sbjct: 3132 ITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQL-------E 3184

Query: 844  NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
             P   E + +  + +   D G P  + T++ TV V++LD+NDN P F+   + A V E I
Sbjct: 3185 KPLDRELQAVYTLSLKAVDQGLPR-RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243

Query: 904  PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
              G  + QV A   D   N  ++Y +  G     F I+S +G V     LD E   EY L
Sbjct: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303

Query: 964  RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
             V A+D GTP+ S  +T+ ++V D+ND TP F    Y   +SED   E  V+ +   D D
Sbjct: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDAD 3363

Query: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHT 1083
               N+ + Y I  GN    F++      V+    LDRET + Y L ++A DNG       
Sbjct: 3364 GPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNG--SPPRV 3421

Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFG-RVWYRIL 1142
             T TV + V DVNDN P+F + +Y   + E+ P G S+LQL  TD D    G   ++ I+
Sbjct: 3422 NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481

Query: 1143 HGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI---VYVE 1199
             GN    F ++    LL      + R+    ++L V+  ++   P  SS+  I   V  E
Sbjct: 3482 TGNDEKAFEVNPQGVLLTSS--AIKRKEKDHYLLQVKVADNG-KPQLSSLTYIDIRVIEE 3538

Query: 1200 DINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEID 1259
             I   A +  +   +  G   + G+   +  + ATD+D  D   + Y +    +  F + 
Sbjct: 3539 SIYPPAILPLEIFITSSGEEYSGGV---IGKIHATDQDVYD--TLTYSLDPQMDNLFSVS 3593

Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATD 1287
             + G +I    LD      Y++NVS TD
Sbjct: 3594 STGGKLIAHKKLDI---GQYLLNVSVTD 3618



 Score =  388 bits (997), Expect = e-107
 Identities = 455/1705 (26%), Positives = 745/1705 (43%), Gaps = 214/1705 (12%)

Query: 1311 VQFSNASYEAAILENLALGTEI---VRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA- 1366
            +QF++  Y   + EN A  T +   V++  Y      ++ Y+     S  ++ LFK +  
Sbjct: 32   LQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKI---VSGDSENLFKAEEY 88

Query: 1367 ITGV-----ITVQG----LVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPR 1417
            I G      I  +G    +++RE  D YTL V A +    V++  KV + VLD ND  P 
Sbjct: 89   ILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPL 148

Query: 1418 FDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIG 1477
            F  TS S VS+PE+  +   +A V A D D G+NG+  +S          ++   + + G
Sbjct: 149  FSPTSYS-VSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-----DMFAIHPTSG 202

Query: 1478 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-----LQVTILDINDNPPVIESPFG 1532
             + +   LD  E   Y ++++A+DRG        I     L V I   N+  PVI +   
Sbjct: 203  VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--- 259

Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGIN-SVLSYYITEGNKDMAFRMDRI---SGEIATR 1588
              +S +E +    A   V   D D G N  + S  I  G+    FR  R    S E   +
Sbjct: 260  VTLSPSE-LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318

Query: 1589 P-APPDRERQSF-YHLVATVEDEGT-PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDE 1645
                 D +   F Y+L    +D+GT P  S+   ++VT          F++  Y   + E
Sbjct: 319  AIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISE 378

Query: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
                 NT ++ ++A+         + Y   +      F ++ + G+I+  + +  +    
Sbjct: 379  FAPP-NTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ-QAA 432

Query: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRV 1763
             + L VT +D+         ++T VLV V   N N P F +  Y+  F+  E  P G  V
Sbjct: 433  HFELEVTTSDR--------KASTKVLVKVLGANSNPPEFTQTAYKAAFD--ENVPIGTTV 482

Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTIC 1822
             +  A D D G NG V YSI + + +  F I    G +   ++  LD E +   Y L I 
Sbjct: 483  MSLSAVDPDEGENGYVTYSIANLNHV-PFAIDHFTGAVSTSEN--LDYELMPRVYTLRIR 539

Query: 1823 ARDRGMPPLSST-MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
            A D G+P      +L  I + ++NDN P+   +    TI  +  V   +  V A DAD  
Sbjct: 540  ASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE- 598

Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLD---RERIPEYKLTISVKDNP------ 1932
                + + I AGN    F +N  +G++++ R L      ++  + L I+  D        
Sbjct: 599  -LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657

Query: 1933 -----------------ENPRIARRDYDLLL-------------IFLSDENDN-HPLFTK 1961
                             E   +A+   + LL             IF    + N H    +
Sbjct: 658  YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717

Query: 1962 STYQA--EVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGV 2018
            ST     +V EN P G+ +  +N    + D D      + Y + G  +   F I+  TG+
Sbjct: 718  STLPTGIQVKENQPVGSSVIFMN----STDLDTGFNGKLVYAVSGGNEDSCFMIDMETGM 773

Query: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLTV 2076
            + + S   +DRE      L + +   D+G+    A  L  + ++D NDN P F   +  V
Sbjct: 774  LKILSP--LDRETTDKYTLNITVY--DLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFV 829

Query: 2077 HLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREE 2136
             + E+      ++QV ATD+D G NG + Y I     D F I  VTGV+ +    +DRE 
Sbjct: 830  EVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGVVNIAR-PLDREL 887

Query: 2137 QESYRLTVVATD--RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIA 2194
            Q  + L + A D  R    L  T +V + ++D+ND+ P F+ P   V V E    GTVI 
Sbjct: 888  QHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIM 947

Query: 2195 NITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATY 2254
             + A D DL    +              L+ + E  F V+  +G+V +   ++ E    Y
Sbjct: 948  WLEAHDPDLGQSGQVRY----------SLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVY 997

Query: 2255 EVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMER--ILEGATPG 2312
             +T+   D    +   S       + V V+DVN+N     P   + ++E+  + E A  G
Sbjct: 998  NLTVRAKDKGKPVSLSS----TCYVEVEVVDVNEN---LHPPVFSSFVEKGTVKEDAPVG 1050

Query: 2313 TTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTV 2372
            + ++ V+A D D   +G + Y++ D    G  ++ + + G +  +  +D E       TV
Sbjct: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEET-GVIETSDRLDRESTSHYWLTV 1109

Query: 2373 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2432
             A+D G  P ++ I +Y+E+ D+NDN P   +P Y   + E+ P    ++ + A D DS 
Sbjct: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169

Query: 2433 NFALIEYSL--GDGESKFAINPTTGDIYVLS-SLDREKKDHYILTALAKDNPGDVASNRR 2489
            +   + Y +  G+ +  F+I+P TG I   S  LDRE++D +IL     DN     S  +
Sbjct: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN----GSPPK 1225

Query: 2490 ENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS-------VITMMATDQDEGPNG 2542
                +V++++LD ND +PQF +  +   + E E            +  ++ATD+DEGPN 
Sbjct: 1226 STIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA 1285

Query: 2543 ELTYSLE-GPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEV 2601
            E++YS+E G     F ++  +G+V+++R   + E   L++ A D G P    TT L +E 
Sbjct: 1286 EISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE- 1344

Query: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYS-------FLK 2654
                     ++  P  ++  I  E    +  + V  +D    + G +          F  
Sbjct: 1345 ---------WISKPKPSLEPISFEESFFT--FTVMESDPVAHMIGVISVEPPGIPLWFDI 1393

Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
            T GN D   F +D  +G I  A+ LD E ++ Y+L + A+D        T    QV ++ 
Sbjct: 1394 TGGNYD-SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD------GTTTILTQVFIKV 1446

Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN-- 2772
            ID N+    RP   + +Y+++ +PE +   T +  ++ AVD DE  N ++Y   ++ +  
Sbjct: 1447 IDTNDH---RPQFSTSKYEVV-IPEDTAPETEILQIS-AVDQDE-KNKLIYTLQSSRDPL 1500

Query: 2773 EEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQE 2831
              K F L P  G L     LD E     +  V                  D+        
Sbjct: 1501 SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQ-------------DVPVKRNFAR 1547

Query: 2832 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYF 2891
            + V + D ND  P FT + Y   V   A VGS ++QV ALD D G N+ V YSI      
Sbjct: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI------ 1601

Query: 2892 RALANDSEDVGQVFTMGSMDGILRT 2916
                 +S ++G  F +  + G ++T
Sbjct: 1602 -----ESGNIGNSFMIDPVLGSIKT 1621



 Score =  297 bits (760), Expect = 1e-79
 Identities = 318/1181 (26%), Positives = 523/1181 (44%), Gaps = 164/1181 (13%)

Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAF-----------F 1900
            +L  N+T+ ENS   ++V H +         A  + + I +G+ E  F           F
Sbjct: 36   HLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCF 95

Query: 1901 INATT--GIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPL 1958
            +   T  G   +   L+RE    Y  T+ VK   +N  +  R    + + + D ND  PL
Sbjct: 96   LRIRTKGGNTAI---LNREVKDHY--TLIVKALEKNTNVEARTK--VRVQVLDTNDLRPL 148

Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGV 2018
            F+ ++Y   + EN+   T +  ++    A DAD        Y     ++ +F I+ ++GV
Sbjct: 149  FSPTSYSVSLPENTAIRTSIARVS----ATDADIGTNGEFYYSFKD-RTDMFAIHPTSGV 203

Query: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGL-------LNSTAHLLITILDDNDNRPTFSP 2071
            + +   +    +     + E+ +LA D G+       ++S A L + I   N+  P  + 
Sbjct: 204  IVLTGRL----DYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA 259

Query: 2072 ATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAG--AQDRFLIHLVTG----- 2123
             TL+   L+   P +++  VT  D D G NG++    I AG   Q    +    G     
Sbjct: 260  VTLSPSELDR-DPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYK 316

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVP-LSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
            V  +G    D      Y LT+ A D+GT P  S   ++ +          +F   +    
Sbjct: 317  VKAIGGIDWD-SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAE 375

Query: 2183 VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
            + E A P T +  + AI         Y  +  V K    +        F++N NTG + +
Sbjct: 376  ISEFAPPNTPVVMVKAIP-------AYSHLRYVFKSTPGKA------KFSLNYNTGLISI 422

Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
              P+ R+  A +E+ ++  D  +          + K+ V VL  N N P+F     T Y 
Sbjct: 423  LEPVKRQQAAHFELEVTTSDRKA----------STKVLVKVLGANSNPPEFTQ---TAYK 469

Query: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
                E    GTT+++++AVDPD+G NG VTY++ +L    +    D   G V  +  +DY
Sbjct: 470  AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAI--DHFTGAVSTSENLDY 527

Query: 2363 EEVHWL-NFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTI 2420
            E +  +    +RASD G P  R  E+   + + ++NDN P+F++ + +  +  D+ VG  
Sbjct: 528  ELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQ 587

Query: 2421 ILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDR---EKKDHYILTALA 2477
            I TV+A DAD       +   G+    F++NP +G + +  SL      K   + L   A
Sbjct: 588  ITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA 647

Query: 2478 KDNPGDVA----------------------------------SNRRENSVQVVIQVLD-- 2501
             D                                        +N+  N  +V     D  
Sbjct: 648  TDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSH 707

Query: 2502 -VNDCRPQF-SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHV 2558
             VN   PQF S       V EN+P G+SVI M +TD D G NG+L Y++ G   ++ F +
Sbjct: 708  SVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI 767

Query: 2559 DMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
            DM++G++    PL  ++ +K++L +   D G P      +L V V+D NDN P F++   
Sbjct: 768  DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ--E 825

Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
               + + E+  + S + +V ATDKD G NG V YS +      D + F ID ++G++  A
Sbjct: 826  SYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT-----DTDTFSIDSVTGVVNIA 880

Query: 2677 QRLDRESQAVYSLILVASDLGQPVP--YETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
            + LDRE Q  +SL + A D  +  P  + T+  ++V+LED++DN P F+      P Y++
Sbjct: 881  RPLDRELQHEHSLKIEARDQAREEPQLFSTVV-VKVSLEDVNDNPPTFI-----PPNYRV 934

Query: 2735 LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDR 2793
              V E  P GT++  +  A D D G +  V Y +   + E NF +    G + +++ LD 
Sbjct: 935  -KVREDLPEGTVIMWLE-AHDPDLGQSGQVRYSLL-DHGEGNFDVDKLSGAVRIVQQLDF 991

Query: 2794 EREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTA 2853
            E++ +++  V+A         +G   +L     +   EV VV  + N  PP F+      
Sbjct: 992  EKKQVYNLTVRAKD-------KGKPVSLSSTCYV---EVEVVDVNENLHPPVFSSFVEKG 1041

Query: 2854 GVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGI 2913
             V  DA VGS ++ V A D D   +  + YSI           D   VG VF +G   G+
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI----------RDGSGVG-VFKIGEETGV 1090

Query: 2914 LRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2954
            + T D     S  ++ + + A D      ++ I IYI  +D
Sbjct: 1091 IETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVED 1131



 Score = 49.3 bits (116), Expect = 6e-05
 Identities = 49/182 (26%), Positives = 77/182 (42%), Gaps = 25/182 (13%)

Query: 2714 DIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNE 2773
            D D ++ L   P + +     +TV E+S   T VG+          P   V Y I +G+ 
Sbjct: 20   DSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDS 79

Query: 2774 EKNF----HLQPDGCLLVLRD-------LDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
            E  F    ++  D C L +R        L+RE +  ++ IVKA    +    R       
Sbjct: 80   ENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEAR------- 132

Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
                    +VRV + D ND  P F+   Y+  +  +  + + + +V A DADIG N   +
Sbjct: 133  -------TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFY 185

Query: 2883 YS 2884
            YS
Sbjct: 186  YS 187


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  895 bits (2314), Expect = 0.0
 Identities = 850/2981 (28%), Positives = 1376/2981 (46%), Gaps = 242/2981 (8%)

Query: 25   VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVE 81
            +NR   + +  F + + + ED PVG+++ ++ A D D   N  ++F +S       F ++
Sbjct: 718  INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777

Query: 82   PDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYS 138
             +TG + +  P+DRE    + +  ++ D    Q    R + I V D NDN+P F    YS
Sbjct: 778  METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYS 837

Query: 139  VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETT 198
            V I E++ +GT I  V A D DLG+ G V YS    +Q FAI+S+ GIV V  +LD E+ 
Sbjct: 838  VNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESK 897

Query: 199  QAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
              Y L + A D+ +  + L ++  L + + DV D  P FI   YS  + E  P GT +  
Sbjct: 898  ANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAW 957

Query: 258  ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
            +   D D G    + Y++V+ + N  F +D  SG + L+  LD E   +   + LTV+  
Sbjct: 958  LETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQF---YNLTVRA- 1012

Query: 318  ELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVD 375
               D   P   +  +   + V+D+N+N   P F       ++ E +++G ++   +QV  
Sbjct: 1013 --KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV---LQVTA 1067

Query: 376  KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
            +DE+ G +   + Y + + S    +   S+  ++ + I  A  LD ET+  Y   ++A +
Sbjct: 1068 RDEDSGRDGEIQ-YSIRDGSG---LGRFSIDDESGV-ITAADILDRETMGSYWLTVYATD 1122

Query: 436  -SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE 494
              V       +V I + + NDN P+ S+P+Y   + EN     SV+ + A D D+ +  +
Sbjct: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEK 1182

Query: 495  VSY-FFSDDPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGG--GEETTGRVRI 549
            ++Y   S +P   F+++  TGLI   +R LD E      L +   DGG   +++T  V +
Sbjct: 1183 LTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVV 1242

Query: 550  NVLDVNDNVPTFQKDAYVGAL--RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFG 607
             VLD NDN P F +  Y   L  R+ +     + R  A D D  PN +I+YSIV  +  G
Sbjct: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302

Query: 608  SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE--- 664
             +F   +    G++S  +    +  +     LT+ A+D G P  +ST  + IE   +   
Sbjct: 1303 KFF---IDPKTGMVSSRK----QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355

Query: 665  NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINAR 724
            +  P TF +P Y  +V+E+      V  ++    +    +     I      + F     
Sbjct: 1356 SPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFD----IVGGNFDSAFDAEKG 1411

Query: 725  SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
             G I     LD E +S Y + V   DG         +  V I +LD NDN P +    Y 
Sbjct: 1412 VGTIVIAKPLDAEQRSIYNMSVEVTDG-----TNVAVTQVFIKVLDNNDNGPEFSQPNYD 1466

Query: 785  INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP-----PNKFYSLNSTTGKIRTTHAM 839
            + + E   PD+++  + A D D  E   L Y++         + + ++ +TG + T    
Sbjct: 1467 VTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAE-R 1523

Query: 840  LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
            LD E  D H   +M      V D   P  +  + A V VN+ D ND+ P F N  + A V
Sbjct: 1524 LDHEAQDKHILNIM------VRDQEFPYRR--NLARVIVNVEDANDHSPYFTNPLYEASV 1575

Query: 900  LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
             E    G ++ QV A+D D+G N  + Y +  G     F I    G++    E D   + 
Sbjct: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635

Query: 960  EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
            ++ L +  +D G+P  S+T+ + I V   ++  P F    Y   V+E+V     V+ ++ 
Sbjct: 1636 QFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA 1695

Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
                    + L Y +  G+++G F++     V+ T   LD E T++Y LI++A +   + 
Sbjct: 1696 IS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGM- 1749

Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEG-------HSILQLKATDADEG 1132
                  ATV + ++D NDN P+FL S Y  S+ E  P         +S L ++ATDAD  
Sbjct: 1750 ---ASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806

Query: 1133 EFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS---HVLIVEAYNHDLGPMR 1189
                + Y+I+       F +  S G + R    LD E  +    HV + ++ +  L    
Sbjct: 1807 RNALLVYQIVESTAKKFFTVDSSTGAI-RTIANLDHETIAHFHFHVHVRDSGSPQL-TAE 1864

Query: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249
            S V V + V D+ND  PVFTQ  +  + L  T  +G  V+ V ATD DS     + Y ++
Sbjct: 1865 SPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY-VGVEVLKVSATDPDSEVPPELTYSLM 1923

Query: 1250 SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL--NEL 1307
             G+   F ID ++G++   N  +  +K  YM+ V  +D      + + +  +T++    +
Sbjct: 1924 EGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD-----GKFYSTSMVTIMVKEAM 1976

Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAI 1367
            D  + F+ + Y  +I EN    T++  V A   + LN+       Y+       FKI + 
Sbjct: 1977 DSGLHFTQSFYSTSISENNTNITKVAIVNAVG-NRLNEPL----KYSILNPGNKFKIKST 2031

Query: 1368 TGVITVQGL-VDREKGDFYTLTVVADDGGPKVD----STVKVYITVLDENDNSPRFDFTS 1422
            +GVI   G+  DRE+ + Y L V   +   ++D    + V V + + D NDNSP F    
Sbjct: 2032 SGVIQTTGVPFDREEQELYELVV---EASRELDHLRVARVVVRVNIEDINDNSPVFVGLP 2088

Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
              A ++  D   G  +  V A D D G NG+V + L      G FEI   N + G V + 
Sbjct: 2089 YYA-AVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD--YGHFEI---NPNSGNVILK 2142

Query: 1483 RPLDREELD-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
               + +  +  Y + ++A D G P       L +TI  +N   PV + PF Y  SVNE++
Sbjct: 2143 EAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPF-YTASVNEDI 2199

Query: 1542 GGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH 1601
               T ++ + AT  +      + Y I +G+    F +D  +G +    +P D E  S Y 
Sbjct: 2200 RMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTSAYK 2255

Query: 1602 LVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALD 1661
            L     D  T   +  T V + + D NDN P+F QP Y   L E    + T ++ + ++D
Sbjct: 2256 LTIRASDALTGARAEVT-VDLLVNDVNDNPPIFDQPTYNTTLSEA-SLIGTPVLQVVSID 2313

Query: 1662 LDEGPNGTVTYAIVAG--NIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ-CP 1718
             D   N  V Y IV    N  + F ID   G+I  A+ LD+E+     TL V + D   P
Sbjct: 2314 ADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ-HCTLKVRSIDSGFP 2372

Query: 1719 ILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQ 1778
             LS    S   V + ++D+NDN P F +     +       G  V    A D DS    +
Sbjct: 2373 SLS----SEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR 2428

Query: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVG 1838
            +EYSI+ G+    F++    GV+ +    +   E +  Y+L +   D G+   +ST  V 
Sbjct: 2429 LEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL--YSLNVSVSD-GL--FTSTAQVH 2483

Query: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA 1898
            IRVL  N   P          + EN    + V HV A+D D G   ++++ I     +  
Sbjct: 2484 IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR 2543

Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPL 1958
            F I++   ++T  R LDRE   E  ++I V+         R  +  + + + DENDN P 
Sbjct: 2544 FLIDSNGQVITTER-LDRENPLEGDVSIFVRALDGG---GRTTFCTVRVIVVDENDNAPQ 2599

Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS----GLFDINS 2014
            F    Y+A V  +   G  +T     + A+D D    + +TY L    S     L +I+ 
Sbjct: 2600 FMTVEYRASVRADVGRGHLVT----QVQAIDPDDGANSRITYSLYSEASVSVADLLEIDP 2655

Query: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPA 2072
              G +  +             +L   + A D G+   +S   + I +L      P+F+ +
Sbjct: 2656 DNGWMVTKGNF----NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711

Query: 2073 TLTVHLLENCPPGFSV--LQVTATDE--DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVG 2128
              +  + E+   G +V  L++  +     S +NGE   R E      F+I   TG I++ 
Sbjct: 2712 QYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGE---RPENNKGGIFVIEQETGTIKL- 2767

Query: 2129 NATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESA 2187
            +  +DRE   ++   V AT     V +  T  V I + D+ND++P F        ++E  
Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGM 2827

Query: 2188 EPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP 2245
              GT +  + AID D   N ++ Y +        +D       +AF ++ NTG +     
Sbjct: 2828 PVGTKLTQVRAIDMDWGANGQVTYSL-------HSDSQPEKVMEAFNIDSNTGWISTLKD 2880

Query: 2246 MNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERI 2305
            ++ E   T+  T SV+  ASDL E       A ++V V D+NDN P F       Y   +
Sbjct: 2881 LDHETDPTF--TFSVV--ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQ---EVYRGNV 2933

Query: 2306 LEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYE 2363
             E   PG  +  ++  D D   +N  V+Y +    P G   L    S  KV   R +D E
Sbjct: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE 2993

Query: 2364 E--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTII 2421
            E  +++LN T  A+D     +A    V + + D+NDN+P+ DQ +Y   + ED+P   II
Sbjct: 2994 EQDIYFLNIT--ATDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048

Query: 2422 LTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDN 2480
            L V+A DAD G+   I YSL G G S+F ++P +G++  L+ LDRE+   Y L A A D 
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG 3108

Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
             G       ++++ ++++  DVND  P FS   ++T VYEN      +  + A D D G 
Sbjct: 3109 GGRFC----QSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGI 3162

Query: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGE-PPLWGTTML 2597
            N ++ YSL       F +D  SG++  ++PL  +    ++++V ATD      L   T +
Sbjct: 3163 NRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTV 3222

Query: 2598 LVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAG 2657
             + V+D+NDN PVF R     ++ + E+    + V  V+AT KD G N  + Y  L  +G
Sbjct: 3223 TITVLDINDNPPVFER--RDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY--LIRSG 3278

Query: 2658 NRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDD 2717
            N   + F I+P +G I  ++ LD E    + L++ A D G P     +  + + L D++D
Sbjct: 3279 NEQGK-FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA-LSAVATVNINLTDVND 3336

Query: 2718 NEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNF 2777
            N      PPK S       + E +  G  V  +  A D D  PN  +++ I  G+ +  F
Sbjct: 3337 N------PPKFSQDVYSAVISEDALVGDSV-ILLIAEDVDSQPNGQIHFSIVNGDRDNEF 3389

Query: 2778 HLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVL 2836
             + P  G + V + LDRER + +S +V+A    S  P    + T           V + +
Sbjct: 3390 TVDPVLGLVKVKKKLDRERVSGYSLLVQAVD--SGIPAMSSTAT-----------VNIDI 3436

Query: 2837 EDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSILAIHYFRALA 2895
             D+ND  P FT A YTA +  +  VG+ ++Q++  D D  +N   F +SIL+        
Sbjct: 3437 SDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILS-------G 3489

Query: 2896 NDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD 2936
            N+ E+    F +    GILR+  +F       +V+ + A+D
Sbjct: 3490 NEEEE----FVL-DPHGILRSAVVFQHTESLEYVLCVQAKD 3525



 Score =  879 bits (2270), Expect = 0.0
 Identities = 847/2948 (28%), Positives = 1321/2948 (44%), Gaps = 254/2948 (8%)

Query: 41   LISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRFFAVEPDTGVVWLRQPLDRE-- 96
            +IS D PVG  +T + A D+D   LV    +SG E   FF + PD+GV+ L++ L     
Sbjct: 586  VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELG-FFYLNPDSGVLQLKKSLTNSGI 644

Query: 97   TKSEFTVEFSVSDHQGVI-----------------------TR----------------- 116
                F +  + +D + +                        TR                 
Sbjct: 645  KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANG 704

Query: 117  KVNIQVG-----DVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS 170
            K+N++ G      +N   P F    P  V + E+ PVG  I  + A D D G  G VL++
Sbjct: 705  KLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFT 764

Query: 171  FQP--PSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITD 228
                     F ID   G + V+  +D E T  Y L +   D    +  S+   L I + D
Sbjct: 765  ISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK-SSWRLLTINVED 823

Query: 229  VQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDY 288
              D  P+FI   YS NI E S  GT +  + A D+D G    + Y++++      FA++ 
Sbjct: 824  ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINS 881

Query: 289  ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
             +G++ +   LDRE+      + L ++  +  +      + V  T  + + D+ND +P F
Sbjct: 882  STGIVYVADQLDRES---KANYSLKIEARDKAESGQQLFSVV--TLKVFLDDVNDCSPAF 936

Query: 349  NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGK 408
              S YSV + E   VG  +  +++  D D  LGL       LV + +  F I       K
Sbjct: 937  IPSSYSVKVLEDLPVGTVI-AWLETHDPD--LGLGGQVRYSLVNDYNGRFEID------K 987

Query: 409  ADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQPL 464
            A   IR++  LDYE    Y+  + A +         V + +V++  +NEN + P F    
Sbjct: 988  ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047

Query: 465  YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLDKDTGLIMLIARLD 522
               S+ EN  +GTSVL V A D D+G  GE+ Y   D     RFS+D ++G+I     LD
Sbjct: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILD 1107

Query: 523  YELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
             E +  + LT+ A D G     +T  V I V DVNDN P   +  Y   + EN P    +
Sbjct: 1108 RETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV 1167

Query: 581  VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
            ++++A D DS  N ++TY I S +   ++F I++  G  + + SR LD EQ +   + +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNP-QNFFAINIKTGL-ITTTSRKLDREQQAEHFLEVT 1225

Query: 641  VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
            V   D G  P  ST+ V ++V DENDN P F +  Y + + E            A   DR
Sbjct: 1226 V--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283

Query: 701  SREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRETKSEY-ILIVRAVDGGVGHNQ 757
                  E     ++G+   +F I+ ++G +++     + T   Y IL ++AVD   G  Q
Sbjct: 1284 DEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK---QFTAGSYDILTIKAVDN--GRPQ 1338

Query: 758  KTGIATVNITLLDINDNH--PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
            K+  A ++I  +        P   D P+Y   V  +   +++  VV+V P    N  L +
Sbjct: 1339 KSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWF 1395

Query: 816  SIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
             I   N   + ++  G      A      P   E   +  + V VTD         +   
Sbjct: 1396 DIVGGNFDSAFDAEKGVGTIVIA-----KPLDAEQRSIYNMSVEVTDGTN-----VAVTQ 1445

Query: 876  VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
            VF+ +LD NDN P F    +   + E +     I Q+ A D DE     +SY +   +  
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDS 1503

Query: 936  MD---FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
            +    F I+ S+GV+ T   LD E   ++ L ++  D   P + + + + ++V D ND +
Sbjct: 1504 ISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHS 1563

Query: 993  PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVV 1052
            P F   +Y  SV E       V+ +   D D G NAEL Y I  GN    F +     ++
Sbjct: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGII 1623

Query: 1053 RTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVP 1112
                  D  T   ++L ++  D G      T    + VT+ D  ++ P F+   Y+A V 
Sbjct: 1624 TICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSD--NSHPKFIHKDYQAEVN 1681

Query: 1113 EDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNS 1172
            E++  G S++ + A          + Y +  G+    F I+  +G++    + LD ER S
Sbjct: 1682 ENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITT-QKALDYERTS 1735

Query: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT------ 1226
            S+ LI++A N  +  M S+  V + + D ND APVF   QYS   L E A I +      
Sbjct: 1736 SYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSG-SLSEAAPINSIVRSLD 1792

Query: 1227 -SVIVVQATDRDSGDGGLVNYRIL-SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVS 1284
             S +V++ATD DS    L+ Y+I+ S A+  F +D STG I T+  LD+ET   +  +V 
Sbjct: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852

Query: 1285 ATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
              D   P    +    V I + +  D    F+ A +E  +L    +G E+++V A   D+
Sbjct: 1853 VRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDS 1912

Query: 1343 --LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS 1400
                ++TY     +       F ID+ +GV+T++   +    D Y L V   DG  K  S
Sbjct: 1913 EVPPELTYSLMEGSLDH----FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG--KFYS 1964

Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
            T  V I V +  D+   F   S  + SI E+     +VA V A     G+        + 
Sbjct: 1965 TSMVTIMVKEAMDSGLHFT-QSFYSTSISENNTNITKVAIVNA----VGNRLNEPLKYSI 2019

Query: 1461 GNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520
             N    F+I +T+  I    V  P DREE + Y L V AS      R    +++V I DI
Sbjct: 2020 LNPGNKFKIKSTSGVIQTTGV--PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077

Query: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDR 1580
            NDN PV      Y  +V  +   GT + QV A D+D G N  ++Y + +      F ++ 
Sbjct: 2078 NDNSPVFVG-LPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH--FEINP 2134

Query: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
             SG +  + A         Y +    +D G P+LS +  + +TIV  N   P+F +P Y 
Sbjct: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYT 2192

Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
              ++E    +NT +++I A      P G  + Y I+ G+    F ID   GV+     LD
Sbjct: 2193 ASVNE-DIRMNTPILSINA----TSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247

Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
            YE++   Y L + A+D   +   R   T  +L  VND+NDN P F +             
Sbjct: 2248 YEVT-SAYKLTIRASD--ALTGARAEVTVDLL--VNDVNDNPPIFDQPTYNTTLSEASLI 2302

Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDG--DPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
            G  V   ++ D DS  N  V Y I+    +    F I    G++   +   LD E +   
Sbjct: 2303 GTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR--MLDHELVQHC 2360

Query: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
             L + + D G P LSS +LV I + D+NDN PV   L     +SE +P   FV  V ASD
Sbjct: 2361 TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASD 2420

Query: 1878 ADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRI 1937
            ADS    RL ++I +GN   +F +++ +G++T++    +   P Y L +SV D       
Sbjct: 2421 ADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTA 2480

Query: 1938 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 1997
                   + I +   N   P F++STY AEV EN  AGT +      + A D D   Y  
Sbjct: 2481 Q------VHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI----HVRATDGDPGTYGQ 2530

Query: 1998 VTYQLLG-AQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL 2056
            ++Y ++       F I+S+  V+T      +DRE      + + + A D G   +   + 
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTER---LDRENPLEGDVSIFVRALDGGGRTTFCTVR 2587

Query: 2057 ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ--- 2113
            + ++D+NDN P F        +  +   G  V QV A D D G N  + Y + + A    
Sbjct: 2588 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSV 2647

Query: 2114 -DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAI-VTILIDDINDSR 2171
             D   I    G + V     ++ +       V A D G +P+  + I V I +       
Sbjct: 2648 ADLLEIDPDNGWM-VTKGNFNQLKNTVLSFFVKAVD-GGIPVKHSLIPVYIHVLPPETFL 2705

Query: 2172 PEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
            P F     + ++ E    G+ +  +  +    +  + +  V      + +R   N+   F
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILP---SQNVWFSTV------NGERPENNKGGIF 2756

Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNT 2290
             +   TG++ +   ++RE    +   +     A+ +P   V +     + + VLD+NDN 
Sbjct: 2757 VIEQETGTIKLDKRLDRETSPAFHFKV-----AATIPLDKVDIVFTVDVDIKVLDLNDNK 2811

Query: 2291 PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE--- 2347
            P F+    + Y   I+EG   GT L  V A+D D G NG VTY+L     P  V      
Sbjct: 2812 PVFE---TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI 2868

Query: 2348 DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPS 2406
            DS+ G +   + +D+E      F+V ASD G     ++   V + + DINDN P+F Q  
Sbjct: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928

Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFAINPTTGD--IYVLS 2461
            Y+  V E  P G ++  ++  D D+ +    + Y +  G+   +FA+     +  +YV  
Sbjct: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR 2988

Query: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
             LDRE++D Y L   A D               V + V DVND  P   +  ++  + E+
Sbjct: 2989 PLDREEQDIYFLNITATD-------GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED 3041

Query: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
             P+   ++ + A D D G NG + YSL G G   F +D +SG + T   L  +    +SL
Sbjct: 3042 IPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSL 3101

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
               ATDGG         L++E  DVNDN PVF      T ++  E    ++ +  V A D
Sbjct: 3102 MAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVY--ENTATKALLTRVQAVD 3157

Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
             D G+N  V YS   +AG      F ID  SG+I   Q LDRE Q+ Y++ + A+D    
Sbjct: 3158 PDIGINRKVVYSLADSAGG----VFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPG 3213

Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
                ++  + + + DI+DN P+F R      +  L+TVPE +  GT V  V  A   D G
Sbjct: 3214 QSLSSLTTVTITVLDINDNPPVFER------RDYLVTVPEDTSPGTQVLAVF-ATSKDIG 3266

Query: 2760 PNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
             NA + Y I +GNE+  F + P  G + V   LD E    F  +V+A          G +
Sbjct: 3267 TNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD--------GGT 3318

Query: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
            P L  VA      V + L D+ND PP+F++  Y+A ++ DA VG  +I ++A D D   N
Sbjct: 3319 PALSAVA-----TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPN 3373

Query: 2879 SLVFYSIL 2886
              + +SI+
Sbjct: 3374 GQIHFSIV 3381



 Score =  861 bits (2224), Expect = 0.0
 Identities = 828/2983 (27%), Positives = 1344/2983 (45%), Gaps = 282/2983 (9%)

Query: 93   LDRETKSEFT--VEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
            L+RE +  +   V+ SV         KVNIQV D+ND  P F    YSV I E+TP+ T 
Sbjct: 117  LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176

Query: 151  IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
            +  V ATD D+G+ G   Y F+     F++    G++++   L+Y+    Y L + A D+
Sbjct: 177  VAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236

Query: 211  DK----TRPLSTLANLAIIITDVQDMDP---IFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
                     +S+ A L + I  + +  P   +  ++P+S    E  P   T  ++T  D 
Sbjct: 237  GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS---LEKEP---TYAVVTVDDL 290

Query: 264  DKGRPRGI-GYTIVSGNTNSIFALDYISGVLTLNGLLDREN---PLYSHGFILTVKGTEL 319
            D G    I   +IV+G+    F L      L    + +R+      + +G+ LT++  + 
Sbjct: 291  DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350

Query: 320  NDDRTPSDATVTTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFA---LPLFIQVVD 375
               +  S        N       D  P  F    Y V+I+E +  G     + L  + +D
Sbjct: 351  GSPQKCSALKAVYIGN----PTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID 406

Query: 376  KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
             +  L           G ++ +F I+P S        I  A PL+    + Y  ++   E
Sbjct: 407  VEYKLS---------PGEDAVYFKINPRSG------LIVTARPLNTVKKEVYKLEVTNKE 451

Query: 436  SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
                    A+V I++ + ND+ P F QPLY+  + E+V VGTSVLTV A+D D G  G +
Sbjct: 452  GDLK----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYI 507

Query: 496  SYFFSD-DPDRFSLDKDTGLIMLIARLDYELI-QRFTLTIIARDGGG---EETTGRVRIN 550
            +Y  +  +   F +++ TG+I     LD+E   + +   + A D G     E+   V I 
Sbjct: 508  TYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIR 567

Query: 551  VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
            + +VNDN P F+K A  G +  + P    +  + A D D      + Y I+S +  G ++
Sbjct: 568  IGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGFFY 625

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN--PPLNSTVPVT---------- 658
               L    GV+ + + L    I NG   L + A D  N   P++  + V           
Sbjct: 626  ---LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFS 682

Query: 659  ------------------------------IEVFDENDNPPTFSKP-AYFVSVVENIMAG 687
                                          ++ +  N   P F K     V+V E++  G
Sbjct: 683  CRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVG 742

Query: 688  ATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILI 745
            A +L + A D D    +  + +    +G+T   F I+  +G++     +DRE    Y+L 
Sbjct: 743  ANILKIKAYDADSG--FNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLN 800

Query: 746  VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
            +   D  +G+ QK+    + I + D NDN P +    Y +N++E +   +++  V A D 
Sbjct: 801  ITIYD--LGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDK 858

Query: 806  DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGR 865
            DLG NG + YS+    + +++NS+TG +      LDRE+   +       + +   D   
Sbjct: 859  DLGSNGEVTYSVLTDTQQFAINSSTGIVYVAD-QLDRESKANY------SLKIEARDKAE 911

Query: 866  PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
               +  S  T+ V L D+ND  P F    +  +VLE +P G  I  +   D D GL G V
Sbjct: 912  SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQV 971

Query: 926  SYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIH 984
             Y + V      F I+ +SG +  + ELD E+   Y L V A D G P   SS S + + 
Sbjct: 972  RYSL-VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030

Query: 985  VLDVNDETPT-FFPAVYNV-SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
            V+DVN+   T +FP    V SV E+      V+ +   D D G + E+ Y I  G+  G+
Sbjct: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR 1090

Query: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
            FS+     V+     LDRET  +Y L + A D G V      T  V++ V DVNDN P+ 
Sbjct: 1091 FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL--YSTIEVYIEVEDVNDNAPLT 1148

Query: 1103 LQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
             +  Y   V E+ P+  S++Q++A D D     ++ YRI  GN  N F I++  GL+   
Sbjct: 1149 SEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTT 1208

Query: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRET 1221
             R LDRE+ + H L V   +    P +S++ V+V V D ND  P F ++ Y  +L  R+ 
Sbjct: 1209 SRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDR 1268

Query: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSY- 1279
               G  +    A DRD G    ++Y I+ G  +GKF ID  TG++ +       T  SY 
Sbjct: 1269 KKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYD 1325

Query: 1280 MMNVSATDQAPPFNQGFCSVYITLLNELDEA---VQFSNASYEAAILENLALGTEIVRVQ 1336
            ++ + A D   P       ++I  + +   +   + F    Y   ++E+  + TEIV V 
Sbjct: 1326 ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVV 1384

Query: 1337 AYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP 1396
            +    N    T  +         + F  +   G I +   +D E+   Y ++V   DG  
Sbjct: 1385 SVQPAN----TPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440

Query: 1397 KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVF 1456
               +  +V+I VLD NDN P F    +  V+I ED      +  ++A D D     ++ +
Sbjct: 1441 V--AVTQVFIKVLDNNDNGPEFS-QPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSY 1495

Query: 1457 SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
            ++ S   + +      + S G ++ A  LD E  D +IL ++  D+  P R+    + V 
Sbjct: 1496 TVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVN 1555

Query: 1517 ILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAF 1576
            + D ND+ P   +P  Y  SV E+   G+AV+QV A D+D G N+ L Y I  GN    F
Sbjct: 1556 VEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMF 1614

Query: 1577 RMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ 1636
            +++ + G I T    PD      + L   V D+G+P +SAT  V +++   +++ P F  
Sbjct: 1615 KIEPVLG-IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIH 1673

Query: 1637 PHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
              Y+  ++E  D + TS+I I A+        T+ Y +  G+I   F I+ + GVIT  K
Sbjct: 1674 KDYQAEVNENVD-IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQK 1727

Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP-RDYEGPFEVT 1755
             LDYE +   Y LI+ AT+        + S  TV + + D NDN P F    Y G   ++
Sbjct: 1728 ALDYERT-SSYQLIIQATNMA-----GMASNATVNIQIVDENDNAPVFLFSQYSG--SLS 1779

Query: 1756 EGQPGPRVWTFL--------AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
            E  P   +   L        A D DS  N  + Y I++      F +    G   +R   
Sbjct: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGA--IRTIA 1837

Query: 1808 ELDRETIAFYNLTICARDRGMPPLS--STMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865
             LD ETIA ++  +  RD G P L+  S + V I V D+NDN PV         +   + 
Sbjct: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897

Query: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV-NRPLDRERIPEYKL 1924
            V   V  V A+D DS     LT+++  G+ +  F I++ +G++T+ N  L ++    Y L
Sbjct: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKNNNLSKD---HYML 1953

Query: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984
             + V D             ++ I + +  D+   FT+S Y   + EN+   T + ++N  
Sbjct: 1954 IVKVSDG------KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNA- 2006

Query: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLA- 2043
                     +   + Y +L      F I S++GV+   +GV  DRE     + EL++ A 
Sbjct: 2007 -----VGNRLNEPLKYSILN-PGNKFKIKSTSGVIQT-TGVPFDRE--EQELYELVVEAS 2057

Query: 2044 -EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNG 2102
             E   L  +   + + I D NDN P F        +  +  PG  + QVTA D+D G NG
Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117

Query: 2103 ELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTI 2162
            E+ Y ++      F I+  +G + +  A         Y +T++A D G   LS +  + I
Sbjct: 2118 EVTYVLQ-DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPI 2176

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDR 2222
             I  +N + P F  P  T SV E     T I +I A   +        I+ I+   D  +
Sbjct: 2177 TI--VNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFK 2229

Query: 2223 LVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVN 2282
                    F ++ +TG + V SP++ E+ + Y++T+   D        +++   A++TV+
Sbjct: 2230 -------QFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD--------ALTGARAEVTVD 2274

Query: 2283 VL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--L 2338
            +L  DVNDN P F       Y   + E +  GT ++ V ++D D   N +V Y ++    
Sbjct: 2275 LLVNDVNDNPPIFDQ---PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTY 2331

Query: 2339 VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDN 2398
                Y  + DSS+G ++  R +D+E V      VR+ D+G P  ++E+ V++ I D+NDN
Sbjct: 2332 NSTDYFHI-DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDN 2390

Query: 2399 NPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGD 2456
             P+F+Q  Y+  V E  P G  +  V A+DADS +F  +EYS+  G+  + F ++  +G 
Sbjct: 2391 PPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGV 2450

Query: 2457 IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
            I + +   +  +  Y L          V+     ++ QV I+VL  N   P FS+  +  
Sbjct: 2451 ITLSNHRKQRMEPLYSLNV-------SVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVA 2503

Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQR-----P 2570
             V EN  AGT VI + ATD D G  G+++Y++      + F +D +  ++TT+R     P
Sbjct: 2504 EVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENP 2563

Query: 2571 LQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
            L+     S+ V A DGG    + T  ++  V+D NDN P F+         +R ++    
Sbjct: 2564 LEG--DVSIFVRALDGGGRTTFCTVRVI--VVDENDNAPQFMTVEYRA--SVRADVGRGH 2617

Query: 2631 NVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLI 2690
             V +V A D D+G N  + YS    A     +   IDP +G + T    ++    V S  
Sbjct: 2618 LVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFF 2677

Query: 2691 LVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV 2750
            + A D G PV + ++ P+ + +   +   P F +      QY   T+ E +  G+ V  +
Sbjct: 2678 VKAVDGGIPVKH-SLIPVYIHVLPPETFLPSFTQ-----SQYS-FTIAEDTAIGSTVDTL 2730

Query: 2751 TGAVDADEGPNAIVYYFIAAGNEEKN-----FHL-QPDGCLLVLRDLDREREAIFSFIVK 2804
                     P+  V++    G   +N     F + Q  G + + + LDRE    F F V 
Sbjct: 2731 RIL------PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVA 2784

Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
            A+          P   +D+V  +   +V + + D+ND  P F  + Y   +     VG++
Sbjct: 2785 ATI---------PLDKVDIVFTV---DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTK 2832

Query: 2865 LIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYS 2924
            L QV A+D D G N  V YS+ +        +  E V + F + S  G + T       +
Sbjct: 2833 LTQVRAIDMDWGANGQVTYSLHS-------DSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885

Query: 2925 PGYFVVDIVARDLA---GHNDTAIIGIYILRDDQRVKIVINEI 2964
               F   +VA DL      + TA++ + +   +    +   E+
Sbjct: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928



 Score =  761 bits (1965), Expect = 0.0
 Identities = 799/2968 (26%), Positives = 1294/2968 (43%), Gaps = 294/2968 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF------FAVEPDTGVVWLRQPLDR 95
            I+E TP+ +SV Q+ A D D      G +GE    F      F+V P +GV+ L   L+ 
Sbjct: 167  IAESTPLRTSVAQVTATDAD-----IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNY 221

Query: 96   ETKSEFTVEFSVSD-------HQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
            + K+ + +E    D       + GV  T K+ + +  +N++APT H       +P +   
Sbjct: 222  DEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIH---VVTHVPFSLEK 278

Query: 148  GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYET-T 198
                 +V   D D GA G +    + +  P  QFF     + +    +   +++D+E+  
Sbjct: 279  EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFP 338

Query: 199  QAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI-FINLPYSTNIYEHSPPGTTVRI 257
              Y LT+ A D+   +  S L     I    +D  PI F    Y  +I E SPPG  V I
Sbjct: 339  YGYNLTLQAKDKGSPQKCSAL-KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAI 397

Query: 258  ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
            +    +    P  + Y +  G     F ++  SG++     L+            TVK  
Sbjct: 398  VKLSPE----PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLN------------TVKKE 441

Query: 318  ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
                + T  +  +     I + D ND+ PEF    Y   + E   VG ++ L +   DKD
Sbjct: 442  VYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV-LTVSASDKD 500

Query: 378  ENLGLNSMFEVYLVGNNSHHFIISP-TSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
            +  G N      +   N   F+I+  T V       I     LD+E+    Y F + A++
Sbjct: 501  K--GENGYITYSIASLNLLPFVINQFTGV-------ISTTEELDFESSPEIYRFIVRASD 551

Query: 436  --SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
              S   H     V I + N NDN P+F +      +  +  VG  +  V A D D     
Sbjct: 552  WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611

Query: 494  EVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQR--FTLTIIARDGGGEETTGRVRINV 551
            +      ++   F L+ D+G++ L   L    I+   F L I A DG        + I+V
Sbjct: 612  KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671

Query: 552  L--------------------------------------------DVNDNVPTFQKDAYV 567
            L                                             +N   P F K    
Sbjct: 672  LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731

Query: 568  G-ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626
              A++E+ P    +++++A D DS  N ++ ++I   +   S F+I +  G   + V  P
Sbjct: 732  DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNT-DSCFNIDMETGQ--LKVLMP 788

Query: 627  LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA 686
            +D E     L+ +T+   D GNP  +S   +TI V D NDN P F + +Y V+++E+   
Sbjct: 789  MDREHTDLYLLNITIY--DLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGI 846

Query: 687  GATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTSLLDRETKSEYILI 745
            G  ++ + A D D         + YS L  + QF IN+ +G +     LDRE+K+ Y L 
Sbjct: 847  GTEIIQVEARDKDLG---SNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLK 903

Query: 746  VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
            + A D      Q   + T+ + L D+ND  P +  + Y + ++E  P  + +  +   DP
Sbjct: 904  IEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP 963

Query: 806  DLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
            DLG  G + YS +   N  + ++  +G IR +  +        +E +    + V   D G
Sbjct: 964  DLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKEL-------DYEKQQFYNLTVRAKDKG 1016

Query: 865  RPPLKATSSATVFVNLLDLNDN--DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
            RP +  +S + V V ++D+N+N   P F +   V  V E    G S+ QV A D D G +
Sbjct: 1017 RP-VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRD 1075

Query: 923  GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
            G + Y +  G     F I+  SGV+     LDRE +  Y L V A+D G     ST  + 
Sbjct: 1076 GEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVY 1135

Query: 983  IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
            I V DVND  P     +Y   V E+ P++  V+ +   D D   N +L+Y IT GN    
Sbjct: 1136 IEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNF 1195

Query: 1043 FSVGYRDAVVRTVV-GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPI 1101
            F++  +  ++ T    LDRE  A + L +   D GP  K+   T  V V VLD NDN+P 
Sbjct: 1196 FAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVLDENDNKPQ 1253

Query: 1102 FLQSSYEASVPE--DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL 1159
            F +  Y+  +PE      G  I +  A D DEG    + Y I+ GN    F I    G++
Sbjct: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313

Query: 1160 MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIN----DEAPVFTQQQYSR 1215
                +       S  +L ++A   D G  + S    +++E I        P+   + +  
Sbjct: 1314 SSRKQ---FTAGSYDILTIKAV--DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN 1368

Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYE 1274
              + E+  +   V VV     ++     + + I+ G  +  F+ ++  G I+    LD E
Sbjct: 1369 FTVMESDRVTEIVGVVSVQPANTP----LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424

Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
             ++ Y M+V  TD     N     V+I +L+  D   +FS  +Y+  I E++   TEI++
Sbjct: 1425 QRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481

Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADD 1393
            ++A   D  ++++Y  ++   + +   F+ID  TGV+     +D E  D + L + V D 
Sbjct: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541

Query: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
              P   +  +V + V D ND+SP F      A S+ E   +G  V  V A D D G N +
Sbjct: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEA-SVFESAALGSAVLQVTALDKDKGENAE 1600

Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
            +++++ +GN    F+I      +G + + +  D   +  ++L +  +D+G+PP     I+
Sbjct: 1601 LIYTIEAGNTGNMFKI---EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657

Query: 1514 QVTI-LDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNK 1572
            ++++ +  N +P  I     Y   VNENV  GT+V+ + A  +     S L Y + +G+ 
Sbjct: 1658 RISVTMSDNSHPKFIHK--DYQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDI 1710

Query: 1573 DMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 1632
            +  F ++  SG I T+ A  D ER S Y L+  ++      +++   V + IVDENDNAP
Sbjct: 1711 NGIFTINPYSGVITTQKA-LDYERTSSYQLI--IQATNMAGMASNATVNIQIVDENDNAP 1767

Query: 1633 MFQQPHYEVLLDEGPD------TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRID 1686
            +F    Y   L E         +L+ S + I+A D D   N  + Y IV       F +D
Sbjct: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVD 1827

Query: 1687 RHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVN--VNDINDNVPT 1743
               G I     LD+E I+H  + + V  +      S +LT+ + V VN  V D+NDN P 
Sbjct: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSG-----SPQLTAESPVEVNIEVTDVNDNPPV 1882

Query: 1744 FPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRV 1803
            F +       +     G  V    A D DS    ++ YS+M+G  L  F+I    GVL +
Sbjct: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTI 1941

Query: 1804 RKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1863
             K+  L ++    Y L +   D       ST +V I V +  D+         + +ISEN
Sbjct: 1942 -KNNNLSKD---HYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN 1994

Query: 1864 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV-TVNRPLDRERIPEY 1922
            +   + VA V A    +  N  L ++I   N    F I +T+G++ T   P DRE    Y
Sbjct: 1995 NTNITKVAIVNA--VGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELY 2050

Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
            +L +      ++ R+AR    ++ + + D NDN P+F    Y A V  ++  GT    L 
Sbjct: 2051 ELVVEASRELDHLRVAR---VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGT----LI 2103

Query: 1983 GPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL--- 2039
              + A+D D+     VTY +L    G F+IN +       SG +I +EAF+  +  +   
Sbjct: 2104 YQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPN-------SGNVILKEAFNSDLSNIEYG 2155

Query: 2040 -LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
              +LA+D G   L+++  L ITI+  N   P F     T  + E+      +L + AT  
Sbjct: 2156 VTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213

Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSG 2156
            +    G +   I+     +F I   TGV++V  + +D E   +Y+LT+ A+D  T     
Sbjct: 2214 EG--QGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTSAYKLTIRASDALT-GARA 2269

Query: 2157 TAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGI 2214
               V +L++D+ND+ P F  P    ++ E++  GT +  + +ID D   N  + Y IV  
Sbjct: 2270 EVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIV-- 2327

Query: 2215 VAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSV 2274
                DT     N  D F ++ ++G ++    ++ ELV     TL V    S  P  S  V
Sbjct: 2328 ---QDT----YNSTDYFHIDSSSGLILTARMLDHELV--QHCTLKVRSIDSGFPSLSSEV 2378

Query: 2275 PNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYT 2334
                + + + DVNDN P F       Y   + E A  G  +  V A D D      + Y+
Sbjct: 2379 ---LVHIYISDVNDNPPVFNQL---IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYS 2432

Query: 2335 LLDLVPPGYVQLEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
            +L         ++  S    ++N R    E ++ LN +V    +G     A+  V++ ++
Sbjct: 2433 ILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV---SDGLFTSTAQ--VHIRVL 2487

Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD--GESKFAIN 2451
              N  +P F Q +Y   V E+V  GT ++ V ATD D G +  I Y++ +   + +F I+
Sbjct: 2488 GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLID 2547

Query: 2452 PTTGDIYVLSSLDREK--KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
             + G +     LDRE   +    +   A D  G      R     V + V+D ND  PQF
Sbjct: 2548 -SNGQVITTERLDRENPLEGDVSIFVRALDGGG------RTTFCTVRVIVVDENDNAPQF 2600

Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG----VEAFHVDMDSGLV 2565
               ++  SV  +   G  V  + A D D+G N  +TYSL         +   +D D+G +
Sbjct: 2601 MTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWM 2660

Query: 2566 TTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIR 2623
             T+      +    S  V A DGG P       + + V+      P F +        I 
Sbjct: 2661 VTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS--FTIA 2718

Query: 2624 EEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES 2683
            E+  + S V  +            V     +   N     F+I+  +G I+  +RLDRE+
Sbjct: 2719 EDTAIGSTVDTLRILPSQNVWFSTVNG---ERPENNKGGIFVIEQETGTIKLDKRLDRET 2775

Query: 2684 QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743
               +   + A+     V       + + + D++DN+P+F      +  Y  + + E  P 
Sbjct: 2776 SPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVF-----ETSSYDTI-IMEGMPV 2829

Query: 2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN----FHLQPD-GCLLVLRDLDREREAI 2798
            GT +  V  A+D D G N  V Y + + ++ +     F++  + G +  L+DLD E +  
Sbjct: 2830 GTKLTQVR-AIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPT 2888

Query: 2799 FSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATD 2858
            F+F V AS         G + +L   A   L  VRV   DIND  P F +  Y   V   
Sbjct: 2889 FTFSVVASD-------LGEAFSLSSTA---LVSVRVT--DINDNAPVFAQEVYRGNVKES 2936

Query: 2859 AKVGSELIQVLALDADIGN-NSLVFYSI 2885
               G  +  +   D D  + N  V Y I
Sbjct: 2937 DPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964



 Score =  696 bits (1795), Expect = 0.0
 Identities = 619/2187 (28%), Positives = 994/2187 (45%), Gaps = 154/2187 (7%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
            P+FTN  ++  +   E   +GS+V Q+ A D D   N  L++ +        F +EP  G
Sbjct: 1564 PYFTNPLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLG 1621

Query: 86   VVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
            ++ + +  D  T  +F +   V+D        T  V I V   +++ P F ++ Y   + 
Sbjct: 1622 IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVN 1681

Query: 143  ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQA 200
            EN  +GT + +++A         +++Y  +    +  F I+   G++T  + LDYE T +
Sbjct: 1682 ENVDIGTSVILISAISQS-----TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSS 1736

Query: 201  YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---- 256
            YQL + AT+      +++ A + I I D  D  P+F+   YS ++ E +P  + VR    
Sbjct: 1737 YQLIIQATNM---AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDN 1793

Query: 257  ---IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
               +I A D D  R   + Y IV       F +D  +G +     LD E   + H  +  
Sbjct: 1794 SPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHV-- 1851

Query: 314  VKGTELNDDRTPS-DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
                 + D  +P   A      NI V D+NDN P F  + +   +     VG  + L + 
Sbjct: 1852 ----HVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV-LKVS 1906

Query: 373  VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
              D D  +     +   L+  +  HF+I   S            + +    + +  + L 
Sbjct: 1907 ATDPDSEVPPELTYS--LMEGSLDHFLIDSNSG----------VLTIKNNNLSKDHYMLI 1954

Query: 433  ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492
               S       + V I +    D+   F+Q  Y+ S+ EN T  T V  V A  N     
Sbjct: 1955 VKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE- 2013

Query: 493  GEVSYFFSDDPDRFSLDKDTGLIMLIA-RLDYELIQRFTLTIIARDGGGEETTGRV--RI 549
              + Y   +  ++F +   +G+I       D E  + + L + A          RV  R+
Sbjct: 2014 -PLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
            N+ D+NDN P F    Y  A++ +    T + ++ A D+D  PN ++TY  V    +G +
Sbjct: 2073 NIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYG-H 2129

Query: 610  FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
            F+I+   G  ++  +   D   I  G+   T++A D G P L+++V + I +   N   P
Sbjct: 2130 FEINPNSGNVILKEAFNSDLSNIEYGV---TILAKDGGKPSLSTSVELPITIV--NKAMP 2184

Query: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGE 727
             F KP Y  SV E+I     +L +NAT  +     GQ  I   ++G    QF I+  +G 
Sbjct: 2185 VFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFKQFNIDFDTGV 2239

Query: 728  ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
            +   S LD E  S Y L +RA D   G   +    TV++ + D+NDN P +    Y   L
Sbjct: 2240 LKVVSPLDYEVTSAYKLTIRASDALTGARAEV---TVDLLVNDVNDNPPIFDQPTYNTTL 2296

Query: 788  VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN----KFYSLNSTTGKIRTTHAMLDRE 843
             E +   + V  VV++D D   N  + Y I         ++ ++S++G I T   MLD  
Sbjct: 2297 SEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR-MLD-- 2353

Query: 844  NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
                HE      + V   D G P L  +S   V + + D+NDN P F  L + + V E  
Sbjct: 2354 ----HELVQHCTLKVRSIDSGFPSL--SSEVLVHIYISDVNDNPPVFNQLIYESYVSELA 2407

Query: 904  PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
            P G  +  V A D D      + Y +  G  R  FL++S SGV+  +    +     Y L
Sbjct: 2408 PRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSL 2467

Query: 964  RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
             V  SD      +ST+ + I VL  N  +P F  + Y   V E+V    +V+ +  TD D
Sbjct: 2468 NVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524

Query: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA--YMLILEAIDNGPVGKR 1081
             G   ++SY I       +F +     V+ T   LDRE        + + A+D G     
Sbjct: 2525 PGTYGQISYAIINDFAKDRFLIDSNGQVI-TTERLDRENPLEGDVSIFVRALDGGG---- 2579

Query: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141
             T   TV V V+D NDN P F+   Y ASV  D+  GH + Q++A D D+G   R+ Y +
Sbjct: 2580 RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSL 2639

Query: 1142 LHG---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYV 1198
                  +  +   I   NG ++      ++ +N+     V+A +  +    S + V ++V
Sbjct: 2640 YSEASVSVADLLEIDPDNGWMVTKGN-FNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHV 2698

Query: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN-YRILSGAEGKFE 1257
                   P FTQ QYS   + E   IG++V  ++     +     VN  R  +   G F 
Sbjct: 2699 LPPETFLPSFTQSQYS-FTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFV 2757

Query: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFC-SVYITLLNELDEAVQFSNA 1316
            I++ TG I     LD ET  ++   V+AT      +  F   V I +L+  D    F  +
Sbjct: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETS 2817

Query: 1317 SYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQ-AKALFKIDAITGVITV 1373
            SY+  I+E + +GT++ +V+A  +D     Q+TY  ++ +  +     F ID+ TG I+ 
Sbjct: 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST 2877

Query: 1374 QGLVDREKGDFYTLTVVADDGGP--KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
               +D E    +T +VVA D G    + ST  V + V D NDN+P F        ++ E 
Sbjct: 2878 LKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRG-NVKES 2936

Query: 1432 CPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
             P G+ VA +  WD D    N QV + +  GN  G F +     S  +V+V RPLDREE 
Sbjct: 2937 DPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ-SEWKVYVKRPLDREEQ 2995

Query: 1491 DHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQV 1550
            D Y L + A+D     +    +++V++ D+NDN PV +    Y   + E++     +++V
Sbjct: 2996 DIYFLNITATDGLFVTQA---MVEVSVSDVNDNSPVCDQ-VAYTALLPEDIPSNKIILKV 3051

Query: 1551 RATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG 1610
             A D DIG N  + Y +  G+ +  F +D  SGE+ T  A  DRER   Y L+A   D G
Sbjct: 3052 SAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELKTL-ALLDRERIPVYSLMAKATDGG 3109

Query: 1611 TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGT 1669
                 +  H+ +   D NDN P+F   HY   + E  +T   +L+T +QA+D D G N  
Sbjct: 3110 GRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYE--NTATKALLTRVQAVDPDIGINRK 3165

Query: 1670 VTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
            V Y++ A +    F ID   G+I   + LD E     Y + V ATDQ P     L+S TT
Sbjct: 3166 VVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE-QQSSYNISVRATDQSP--GQSLSSLTT 3221

Query: 1730 VLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL 1789
            V + V DINDN P F R         +  PG +V    A  +D G N ++ Y I  G+  
Sbjct: 3222 VTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQ 3281

Query: 1790 GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDP 1849
            G+F I+P  G + V +   LD E    + L + A+D G P LS+   V I + D+NDN P
Sbjct: 3282 GKFKINPKTGGISVSE--VLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339

Query: 1850 VLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVT 1909
                   +  ISE++ V   V  ++A D DS  N ++ F+I  G+R+  F ++   G+V 
Sbjct: 3340 KFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVK 3399

Query: 1910 VNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
            V + LDRER+  Y L +   D+  P     A  + D     +SD NDN P+FT + Y A 
Sbjct: 3400 VKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNID-----ISDVNDNSPVFTPANYTAV 3454

Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIY---AVVTYQLLGAQSGLFDINSSTGVVTVRSG 2024
            + EN P GT +  L      +  D+D +      ++ +L        +    G+  +RS 
Sbjct: 3455 IQENKPVGTSILQL------VVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGI--LRSA 3506

Query: 2025 VIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDNDNRPTFSPATLTVHLLENC 2082
            V+         +  L + A+D G     +H  + + +++++ ++PT  P  + +  +E+ 
Sbjct: 3507 VVFQHTESLEYV--LCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDD 3564

Query: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTG-VIRVGNATIDREEQESYR 2141
             PG  + ++ ATD+D  +   L + +++  +  F ++   G +I +G       +   Y 
Sbjct: 3565 FPGGVIGKIHATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGL-----DSGKYV 3617

Query: 2142 LTVVATD-RGTVPLSGTAIVTILIDDI 2167
            L V  +D R  VP+     V  L+ ++
Sbjct: 3618 LNVSVSDGRFQVPIDVVVHVEQLVHEM 3644



 Score =  689 bits (1778), Expect = 0.0
 Identities = 653/2289 (28%), Positives = 1026/2289 (44%), Gaps = 165/2289 (7%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND-PLVFGVSGEEAS---RFFAVEPDT 84
            P F+   +D  + ISED    + + Q+ A D D    L + V     S   R F ++P T
Sbjct: 1458 PEFSQPNYD--VTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPST 1515

Query: 85   GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRI 141
            GV++  + LD E + +  +   V D +    R   +V + V D ND++P F N  Y   +
Sbjct: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575

Query: 142  PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
             E+  +G+ +  V A D D G    ++Y+ +  +    F I+   GI+T+ +E D  T  
Sbjct: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635

Query: 200  AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
             + L++  TDQ    P+S  A + I +T   +  P FI+  Y   + E+   GT+V +I+
Sbjct: 1636 QFVLSIKVTDQGSP-PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694

Query: 260  AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
            AI Q       + Y +  G+ N IF ++  SGV+T    LD E    +  + L ++ T +
Sbjct: 1695 AISQST-----LIYEVKDGDINGIFTINPYSGVITTQKALDYER---TSSYQLIIQATNM 1746

Query: 320  NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL------PLFIQV 373
                  S+ATV    NI ++D NDNAP F  S+YS +++E A +   +      PL I+ 
Sbjct: 1747 AG--MASNATV----NIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800

Query: 374  VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
             D D N   N++    +V + +  F    +S        IR    LD+ET+  + F +  
Sbjct: 1801 TDADSNR--NALLVYQIVESTAKKFFTVDSSTGA-----IRTIANLDHETIAHFHFHVHV 1853

Query: 434  NESVPDHV---GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
             +S    +      +V I + + NDN P+F+Q ++   L     VG  VL V ATD D+ 
Sbjct: 1854 RDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSE 1913

Query: 491  TFGEVSYFFSDDP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRI 549
               E++Y   +   D F +D ++G++ +    +  L +   + I+    G   +T  V I
Sbjct: 1914 VPPELTYSLMEGSLDHFLIDSNSGVLTI---KNNNLSKDHYMLIVKVSDGKFYSTSMVTI 1970

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
             V +  D+   F +  Y  ++ EN  ++T++  + A       N  + YSI++    G+ 
Sbjct: 1971 MVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNP---GNK 2025

Query: 610  FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
            F I    G  + +   P D E+    L  L V A    +    + V V + + D NDN P
Sbjct: 2026 FKIKSTSGV-IQTTGVPFDREE--QELYELVVEASRELDHLRVARVVVRVNIEDINDNSP 2082

Query: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST-QFRINARSGEI 728
             F    Y+ +V  +   G  +  + A D D+        + Y L+     F IN  SG +
Sbjct: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN---GEVTYVLQDDYGHFEINPNSGNV 2139

Query: 729  TTTSLLDRETKS-EYILIVRAVDGGVGHNQKTGIAT-VNITLLDINDNHPTWKDAPYYIN 786
                  + +  + EY + + A DGG     K  ++T V + +  +N   P + D P+Y  
Sbjct: 2140 ILKEAFNSDLSNIEYGVTILAKDGG-----KPSLSTSVELPITIVNKAMPVF-DKPFYTA 2193

Query: 787  LVEMTPPDSDV---TTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAMLD 841
             V     + D+   T +++++    E   ++Y I    P K ++++  TG ++       
Sbjct: 2194 SV-----NEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVV----- 2243

Query: 842  RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
              +P  +E     K+ +  +D       A +  TV + + D+NDN P F    +   + E
Sbjct: 2244 --SPLDYEVTSAYKLTIRASDA---LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSE 2298

Query: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD--FLINSSSGVVVTTTELDRERIA 959
                G  + QVV+ID D   N +V Y++          F I+SSSG+++T   LD E + 
Sbjct: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ 2358

Query: 960  EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
               L+V + D+G P+ SS   + I++ DVND  P F   +Y   VSE  PR   V  +  
Sbjct: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418

Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
            +D D      L Y I  GN    F +  +  V+       +     Y L +   D     
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---- 2474

Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY 1139
               T TA V + VL  N   P F QS+Y A V E++  G  ++ ++ATD D G +G++ Y
Sbjct: 2475 -LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY 2533

Query: 1140 RILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVE 1199
             I++    + F I  SNG ++   R LDRE      + +     D G   +   V V V 
Sbjct: 2534 AIINDFAKDRFLID-SNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVV 2591

Query: 1200 DINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK---- 1255
            D ND AP F   +Y R  +R   G G  V  VQA D D G    + Y + S A       
Sbjct: 2592 DENDNAPQFMTVEY-RASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650

Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
             EID   G ++T    +    T     V A D   P       VYI +L        F+ 
Sbjct: 2651 LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710

Query: 1316 ASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQG 1375
            + Y   I E+ A+G+ +  ++     N+   T       + +   +F I+  TG I +  
Sbjct: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKG-GIFVIEQETGTIKLDK 2769

Query: 1376 LVDREKGDFYTLTVVADDGGPKVDS--TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
             +DRE    +   V A     KVD   TV V I VLD NDN P F+ +S   + I E  P
Sbjct: 2770 RLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI-IMEGMP 2828

Query: 1434 VGQRVATVKAWDPDAGSNGQVVFSLASGN----IAGAFEIVTTNDSIGEVFVARPLDREE 1489
            VG ++  V+A D D G+NGQV +SL S +    +  AF I   + + G +   + LD E 
Sbjct: 2829 VGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSNTGWISTLKDLDHET 2885

Query: 1490 LDHYILQVVASDRGTP-PRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVV 1548
               +   VVASD G         ++ V + DINDN PV      Y  +V E+   G  V 
Sbjct: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV-YRGNVKESDPPGEVVA 2944

Query: 1549 QVRATDRDIG-INSVLSYYITEGNKDMAFRMDRISGEIATRPAPP-DRERQSFYHLVATV 1606
             +   DRD   +N  +SY+IT GN    F +  +  E       P DRE Q  Y L  T 
Sbjct: 2945 VLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITA 3004

Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGP 1666
             D    T +    V V++ D NDN+P+  Q  Y  LL E   + N  ++ + A D D G 
Sbjct: 3005 TDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPS-NKIILKVSAKDADIGS 3060

Query: 1667 NGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTS 1726
            NG + Y++  G+  + F +D   G +     LD E     Y+L+  ATD       R   
Sbjct: 3061 NGYIRYSLY-GSGNSEFFLDPESGELKTLALLDRE-RIPVYSLMAKATDG----GGRFCQ 3114

Query: 1727 TTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDG 1786
            +   L+ + D+NDN P F  D+              +    A D D G N +V YS+ D 
Sbjct: 3115 SNIHLI-LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173

Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM-PPLSSTMLVGIRVLDIN 1845
               G F I    G++ + +   LDRE  + YN+++ A D+     LSS   V I VLDIN
Sbjct: 3174 AG-GVFSIDSSSGIIILEQP--LDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIN 3230

Query: 1846 DNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATT 1905
            DN PV       +T+ E++   + V  V A+  D G NA +T+ I +GN +  F IN  T
Sbjct: 3231 DNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKT 3290

Query: 1906 GIVTVNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
            G ++V+  LD E    + L +  KD   P    +A  +     I L+D NDN P F++  
Sbjct: 3291 GGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVN-----INLTDVNDNPPKFSQDV 3345

Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVR 2022
            Y A + E++  G  + +L    +A D D      + + ++ G +   F ++   G+V V+
Sbjct: 3346 YSAVISEDALVGDSVILL----IAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVK 3401

Query: 2023 SGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLE 2080
                +DRE  S     LL+ A D G+  ++STA + I I D NDN P F+PA  T  + E
Sbjct: 3402 KK--LDRERVSG--YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQE 3457

Query: 2081 NCPPGFSVLQVTATDEDSGLNGE-LVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQES 2139
            N P G S+LQ+  TD DS  NG    + I +G ++   +    G++R         E   
Sbjct: 3458 NKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSA-VVFQHTESLE 3516

Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
            Y L V A D G         + + + + +  +P  +     +  +E   PG VI  I A 
Sbjct: 3517 YVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHAT 3576

Query: 2200 DHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
            D D+     Y ++    K +       Q+  F VN + G ++    ++      Y + +S
Sbjct: 3577 DQDM-----YDVLTFALKSE-------QKSLFKVNSHDGKIIALGGLDS---GKYVLNVS 3621

Query: 2260 VIDNASDLP 2268
            V D    +P
Sbjct: 3622 VSDGRFQVP 3630



 Score =  587 bits (1514), Expect = e-167
 Identities = 609/2263 (26%), Positives = 995/2263 (43%), Gaps = 270/2263 (11%)

Query: 720  RINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
            RI  + G    +++L+RE +  Y+LIV+   G V          VNI +LD+ND  P + 
Sbjct: 106  RIRTKGGN---SAILNREIQDNYLLIVK---GSVRGEDLEAWTKVNIQVLDMNDLRPLFS 159

Query: 780  DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
               Y + + E TP  + V  V A D D+G NG   Y  +     +S++ T+G I  +   
Sbjct: 160  PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLS-GR 218

Query: 840  LDRENPDPHEAELMRKIVVSVTDCGRPPLK---ATSSATVFVNLLDLNDNDPTFQNLPFV 896
            L+ +  + ++ E++        D G         +S+A ++V++  +N++ PT   +  V
Sbjct: 219  LNYDEKNRYDLEIL------AVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHV 272

Query: 897  AEVLEGIPAGVSIYQVVAID-LDEGLNGLV-SYRMPVGMPRMDFLINSSSGVVVTTTELD 954
               LE  P     Y VV +D LD+G NG + S  +  G P   F +      +      +
Sbjct: 273  PFSLEKEPT----YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKE 328

Query: 955  RERIA------EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPA-VYNVSVSED 1007
            R++I        Y L + A D G+P K S            D  P  F   VY+VS+SE 
Sbjct: 329  RKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEF 388

Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
             P    V  +  +   +    ++ Y ++ G     F +  R  ++ T   L+      Y 
Sbjct: 389  SPPGVVVAIVKLSPEPI----DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYK 444

Query: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKAT 1127
            L +         K     A V +++ D ND+ P F Q  Y+A V E +P G S+L + A+
Sbjct: 445  LEV-------TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497

Query: 1128 DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS-HVLIVEA------ 1180
            D D+GE G + Y I   N    F I+   G++      LD E +   +  IV A      
Sbjct: 498  DKDKGENGYITYSIASLNL-LPFVINQFTGVIST-TEELDFESSPEIYRFIVRASDWGSP 555

Query: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
            Y H+     S V V + + ++ND +P+F +     + +     +G  +  V A D D  +
Sbjct: 556  YRHE-----SEVNVTIRIGNVNDNSPLFEKVACQGV-ISYDFPVGGHITAVSAIDIDELE 609

Query: 1241 GGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYE--TKTSYMMNVSATD---QAPPFNQ 1294
              LV Y+I+SG E G F ++  +G++     L        ++ + ++ATD    A P   
Sbjct: 610  --LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPM-- 665

Query: 1295 GFCSVYITLLNELDEAVQFS---------------------------------------- 1314
               S+ I++L+    +  FS                                        
Sbjct: 666  ---SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQG 722

Query: 1315 -----NASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
                 +   + A+ E+L +G  I++++AY  D+       F   +     + F ID  TG
Sbjct: 723  PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLF-TISDGNTDSCFNIDMETG 781

Query: 1370 VITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
             + V   +DRE  D Y L + + D G P+  S   + I V D NDNSP F      +V+I
Sbjct: 782  QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVF-IQDSYSVNI 840

Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
             E   +G  +  V+A D D GSNG+V +S+ +       +    N S G V+VA  LDRE
Sbjct: 841  LESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT-----QQFAINSSTGIVYVADQLDRE 895

Query: 1489 ELDHYILQVVASDRGTPPRKKDHI--LQVTILDINDNPPVIESPFGYNVSVNENVGGGTA 1546
               +Y L++ A D+    ++   +  L+V + D+ND  P    P  Y+V V E++  GT 
Sbjct: 896  SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF-IPSSYSVKVLEDLPVGTV 954

Query: 1547 VVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATV 1606
            +  +   D D+G+   + Y +   + +  F +D+ SG I       D E+Q FY+L    
Sbjct: 955  IAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRL-SKELDYEKQQFYNLTVRA 1012

Query: 1607 EDEGTP-TLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDT-LNTSLITIQALDLDE 1664
            +D+G P +LS+ + V V +VD N+N      P + V+     ++ + TS++ + A D D 
Sbjct: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072

Query: 1665 GPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRL 1724
            G +G + Y+I  G+ +  F ID   GVITAA  LD E + G Y L V ATD+  +    L
Sbjct: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRE-TMGSYWLTVYATDRGVV---PL 1128

Query: 1725 TSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIM 1784
             ST  V + V D+NDN P        P  +        V    A D DS  N ++ Y I 
Sbjct: 1129 YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188

Query: 1785 DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDI 1844
             G+P   F I+   G++      +LDRE  A + L +   D G  P  ST+ V ++VLD 
Sbjct: 1189 SGNPQNFFAINIKTGLITTTSR-KLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE 1247

Query: 1845 NDNDPVLLNLPMNITISE--NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFIN 1902
            NDN P        I + E         +    A D D G NA ++++I  GN +  FFI+
Sbjct: 1248 NDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFID 1307

Query: 1903 ATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKS 1962
              TG+V+  +                       +     YD+L I   D        T  
Sbjct: 1308 PKTGMVSSRK-----------------------QFTAGSYDILTIKAVDNGRPQKSSTAR 1344

Query: 1963 TYQAEVMENSPAGTPLT----VLNGPILALDADQDIYAVVTYQLLGAQ------SGLFD- 2011
             +   + +  P+  PLT      N  ++  D   +I  VV+ Q            G FD 
Sbjct: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDS 1404

Query: 2012 -INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
              ++  GV T+     +D E  S  I  + +   D G   +   + I +LD+NDN P FS
Sbjct: 1405 AFDAEKGVGTIVIAKPLDAEQRS--IYNMSVEVTD-GTNVAVTQVFIKVLDNNDNGPEFS 1461

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIEAGAQDRFLIHLVTGVIRVG 2128
                 V + E+  P   +LQ+ ATD D    L+  +   I++ +  +F I   TGV+   
Sbjct: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521

Query: 2129 NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
               +D E Q+ + L ++  D+        A V + ++D ND  P F NP+   SV ESA 
Sbjct: 1522 E-RLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAA 1580

Query: 2189 PGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
             G+ +  +TA+D D   N +L Y I              N  + F +    G + +    
Sbjct: 1581 LGSAVLQVTALDKDKGENAELIYTIE-----------AGNTGNMFKIEPVLGIITICKEP 1629

Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
            +   +  + +++ V D  S  P  S +   A + ++V   +++ P+F       Y   + 
Sbjct: 1630 DMTTMGQFVLSIKVTDQGS--PPMSAT---AIVRISVTMSDNSHPKFIH---KDYQAEVN 1681

Query: 2307 EGATPGTTLIAVAAVD--------PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANR 2358
            E    GT++I ++A+          D  +NG+ T               +  +G +   +
Sbjct: 1682 ENVDIGTSVILISAISQSTLIYEVKDGDINGIFTI--------------NPYSGVITTQK 1727

Query: 2359 TVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVG 2418
             +DYE        ++A++      A+   V ++IVD NDN P+F    Y  ++ E  P+ 
Sbjct: 1728 ALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785

Query: 2419 TII-------LTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKD 2469
            +I+       L + ATDADS   AL+ Y + +  +K  F ++ +TG I  +++LD E   
Sbjct: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIA 1845

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
            H+      +D+     +   E+ V+V I+V DVND  P F++  F T +      G  V+
Sbjct: 1846 HFHFHVHVRDSGSPQLT--AESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVL 1903

Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEP 2589
             + ATD D     ELTYSL    ++ F +D +SG++T +    S + + L V  +DG   
Sbjct: 1904 KVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDG--- 1960

Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK-DEGLNGAV 2648
              + T+M+ + V +  D+   F +    T +         +N+ +V   +     LN  +
Sbjct: 1961 KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN-----NTNITKVAIVNAVGNRLNEPL 2015

Query: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQ-TAQRLDRESQAVYSLILVASDLGQPVPYETMQP 2707
            +YS L   GN+    F I   SG+IQ T    DRE Q +Y L++ AS     +    +  
Sbjct: 2016 KYSIL-NPGNK----FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARV-V 2069

Query: 2708 LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF 2767
            ++V +EDI+DN P+FV    G P Y  + V   +  GTL+  VT A+D D+GPN  V Y 
Sbjct: 2070 VRVNIEDINDNSPVFV----GLPYYAAVQV--DAEPGTLIYQVT-AIDKDKGPNGEVTYV 2122

Query: 2768 IAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
            +   ++  +F + P+   ++L      +EA  S +       +     G  P+L    +L
Sbjct: 2123 LQ--DDYGHFEINPNSGNVIL------KEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174

Query: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLA 2870
             +  V       N   P F K  YTA V  D ++ + ++ + A
Sbjct: 2175 PITIV-------NKAMPVFDKPFYTASVNEDIRMNTPILSINA 2210



 Score =  466 bits (1199), Expect = e-130
 Identities = 477/1819 (26%), Positives = 829/1819 (45%), Gaps = 228/1819 (12%)

Query: 1244 VNYRILSG-AEGKFEIDESTGLIITVNY--------------LDYETKTSYMMNVSATDQ 1288
            + YRI+SG  EG F+ +E    +I  ++              L+ E + +Y++ V  + +
Sbjct: 79   IKYRIVSGDEEGFFKAEE----VIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134

Query: 1289 APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQI 1346
                 + +  V I +L+  D    FS  +Y   I E+  L T + +V A   D  +  + 
Sbjct: 135  GEDL-EAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193

Query: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK------VDS 1400
             Y F          LF +   +GVI++ G ++ ++ + Y L ++A D G K      V S
Sbjct: 194  YYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSS 248

Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVV-FSLA 1459
            T K+Y+ +   N+++P     +    S+ ++       A V   D D G+NG++   S+ 
Sbjct: 249  TAKLYVHIERINEHAPTIHVVTHVPFSLEKE----PTYAVVTVDDLDDGANGEIESVSIV 304

Query: 1460 SGNIAGAFEIVTTNDSIGEVFVA--RPLDREELDH-YILQVVASDRGTPPRKKDHILQVT 1516
            +G+    F +      + E  +   + +D E   + Y L + A D+G+P  +K   L+  
Sbjct: 305  AGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSP--QKCSALKAV 362

Query: 1517 ILD--INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM 1574
             +     D  P+      Y+VS++E    G  V  V+ +   I +     Y ++ G   +
Sbjct: 363  YIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----YKLSPGEDAV 418

Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF 1634
             F+++  SG I T   P +  ++  Y L  T   EG         V ++I D ND+ P F
Sbjct: 419  YFKINPRSGLIVTA-RPLNTVKKEVYKLEVT-NKEG----DLKAQVTISIEDANDHTPEF 472

Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
            QQP Y+  ++E    + TS++T+ A D D+G NG +TY+I + N++  F I++  GVI+ 
Sbjct: 473  QQPLYDAYVNESVP-VGTSVLTVSASDKDKGENGYITYSIASLNLL-PFVINQFTGVIST 530

Query: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR-------D 1747
             +ELD+E S   Y  IV A+D      H   S   V + + ++NDN P F +        
Sbjct: 531  TEELDFESSPEIYRFIVRASDWGSPYRHE--SEVNVTIRIGNVNDNSPLFEKVACQGVIS 588

Query: 1748 YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
            Y+ P        G  +    A D D      V+Y I+ G+ LG F ++P  GVL+++K +
Sbjct: 589  YDFPV-------GGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSL 639

Query: 1808 ---------------ELDRETIA---FYNLTI-----------CARDRGMPPLSSTMLVG 1838
                             D E +A     N+++           C   R    L+  +L+ 
Sbjct: 640  TNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699

Query: 1839 IRV-------------LDINDNDPVL-LNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884
             +                IN   P    + P ++ + E+ PV + +  + A DADSG N 
Sbjct: 700  AKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759

Query: 1885 RLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRIARRDY 1942
            ++ F I+ GN +  F I+  TG + V  P+DRE    Y L I++ D  NP+     +  +
Sbjct: 760  KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ-----KSSW 814

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
             LL I + D NDN P+F + +Y   ++E+S  GT +      + A D D      VTY +
Sbjct: 815  RLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII----QVEARDKDLGSNGEVTYSV 870

Query: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDD 2062
            L   +  F INSSTG+V V   +  + +A     +E    AE    L S   L + + D 
Sbjct: 871  L-TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929

Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2122
            ND  P F P++ +V +LE+ P G  +  +   D D GL G++ Y +      RF I   +
Sbjct: 930  NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKAS 989

Query: 2123 GVIRVGNATIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDS--RPEFLNPIQ 2179
            G IR+ +  +D E+Q+ Y LTV A D+G  V LS  + V + + D+N++   P F +   
Sbjct: 990  GAIRL-SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048

Query: 2180 TVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
              SV E++  GT +  +TA D D   + +++Y I     +D +          F+++  +
Sbjct: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI-----RDGSGL------GRFSIDDES 1097

Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
            G +     ++RE + +Y +T+   D    +P  S      ++ + V DVNDN P      
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGV-VPLYS----TIEVYIEVEDVNDNAPLTSE-- 1150

Query: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
               Y   ++E +    ++I + A DPD   N  +TY +    P  +  +   +      +
Sbjct: 1151 -PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209

Query: 2358 RTVDYEE--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE-- 2413
            R +D E+   H+L  TV  +D G  P+ + I V ++++D NDN P F +  YQ  + E  
Sbjct: 1210 RKLDREQQAEHFLEVTV--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267

Query: 2414 DVPVGTIILTVTATDADSGNFALIEYSLGDG--ESKFAINPTTGDIYVLSSLDREKKDHY 2471
                G  I    A D D G  A I YS+ DG  + KF I+P TG   ++SS  +     Y
Sbjct: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSY 1324

Query: 2472 -ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP---QFSKPQFSTSVYENEPAGTS 2527
             ILT  A DN       ++ ++ ++ I+ +      P    F +P ++ +V E++   T 
Sbjct: 1325 DILTIKAVDN----GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TE 1379

Query: 2528 VITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPLQSYEK--FSLTVVAT 2584
            ++ +++    +  N  L + + G   + AF  +   G +   +PL + ++  ++++V  T
Sbjct: 1380 IVGVVSV---QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVT 1436

Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644
            DG        T + ++V+D NDN P F +P     + I E++   + + ++ ATD+DE  
Sbjct: 1437 DGTNV---AVTQVFIKVLDNNDNGPEFSQP--NYDVTISEDVLPDTEILQIEATDRDE-- 1489

Query: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY-E 2703
               + Y+   +  +     F IDP +G++ TA+RLD E+Q  + L ++  D  Q  PY  
Sbjct: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRR 1547

Query: 2704 TMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAI 2763
             +  + V +ED +D+ P F      +P Y+  +V E +  G+ V  VT A+D D+G NA 
Sbjct: 1548 NLARVIVNVEDANDHSPYFT-----NPLYE-ASVFESAALGSAVLQVT-ALDKDKGENAE 1600

Query: 2764 VYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
            + Y I AGN    F ++P  G + + ++ D      F   +K +   S  PP   +    
Sbjct: 1601 LIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGS--PPMSATAI-- 1656

Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
                     VR+ +   ++  P+F   +Y A V  +  +G+ +I + A+     + S + 
Sbjct: 1657 ---------VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLI 1702

Query: 2883 YSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHND 2942
            Y +              D+  +FT+    G++ T           + + I A ++AG   
Sbjct: 1703 YEV-----------KDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS 1751

Query: 2943 TAIIGIYILRDDQRVKIVI 2961
             A + I I+ ++    + +
Sbjct: 1752 NATVNIQIVDENDNAPVFL 1770



 Score =  226 bits (577), Expect = 2e-58
 Identities = 266/997 (26%), Positives = 429/997 (43%), Gaps = 132/997 (13%)

Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNG-PILALDADQDI-YAVVTYQLLGAQSGLFD----I 2012
            FT S Y A V ENS A T +   +   I  +D   DI Y +V+    G + G F     I
Sbjct: 43   FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVS----GDEEGFFKAEEVI 98

Query: 2013 NSSTGVVTVR----SGVIIDREAFSPPILEL--LLLAEDIGLLNSTAHLLITILDDNDNR 2066
             +    + +R    +  I++RE     +L +   +  ED   L +   + I +LD ND R
Sbjct: 99   IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED---LEAWTKVNIQVLDMNDLR 155

Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
            P FSP T +V + E+ P   SV QVTATD D G NGE  Y  +    D F +H  +GVI 
Sbjct: 156  PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK-NKVDLFSVHPTSGVIS 214

Query: 2127 VGNATIDREEQESYRLTVVATDR-----GTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
            + +  ++ +E+  Y L ++A DR     G   +S TA + + I+ IN+  P  ++ +  V
Sbjct: 215  L-SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPT-IHVVTHV 272

Query: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
                  EP   +  +  +D   N ++E   V IVA D  D+    +E  +   +N   + 
Sbjct: 273  PFSLEKEPTYAVVTVDDLDDGANGEIE--SVSIVAGDPLDQFFLAKEGKW---LNEYKIK 327

Query: 2242 VKSPMNRE-LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP--FGI 2298
             +  ++ E     Y +TL   D  S         P     +  + + + T    P  F  
Sbjct: 328  ERKQIDWESFPYGYNLTLQAKDKGS---------PQKCSALKAVYIGNPTRDTVPIRFEK 378

Query: 2299 TYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANR 2358
              Y   I E + PG  ++A+  + P+      V Y L       Y ++   S G ++  R
Sbjct: 379  EVYDVSISEFSPPG-VVVAIVKLSPEP---IDVEYKLSPGEDAVYFKINPRS-GLIVTAR 433

Query: 2359 TVD--YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
             ++   +EV+ L  T +  D        +  V + I D ND+ P F QP Y   V E VP
Sbjct: 434  PLNTVKKEVYKLEVTNKEGD-------LKAQVTISIEDANDHTPEFQQPLYDAYVNESVP 486

Query: 2417 VGTIILTVTATDADSGNFALIEYSLGD-GESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
            VGT +LTV+A+D D G    I YS+       F IN  TG I     LD E         
Sbjct: 487  VGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFI 546

Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
            +   + G  +  R E+ V V I++ +VND  P F K      +  + P G  +  + A D
Sbjct: 547  VRASDWG--SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAID 604

Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQS----YEKFSLTVVATDG---GE 2588
             DE    +    + G  +  F+++ DSG++  ++ L +       F+L + ATDG    +
Sbjct: 605  IDELELVKYKI-ISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663

Query: 2589 PPLWGTTML---------------------------------------LVEVIDVNDNRP 2609
            P     ++L                                        ++   +N   P
Sbjct: 664  PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723

Query: 2610 VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI 2669
             F +     +  ++E++P+ +N+ ++ A D D G NG V ++   + GN D   F ID  
Sbjct: 724  YFDKSFPSDVA-VKEDLPVGANILKIKAYDADSGFNGKVLFTI--SDGNTD-SCFNIDME 779

Query: 2670 SGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2729
            +G ++    +DRE   +Y L +   DLG P    + + L + +ED +DN P+F++     
Sbjct: 780  TGQLKVLMPMDREHTDLYLLNITIYDLGNP-QKSSWRLLTINVEDANDNSPVFIQDSYS- 837

Query: 2730 PQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR 2789
                 + + E S  GT +  V  A D D G N  V Y +    ++   +    G + V  
Sbjct: 838  -----VNILESSGIGTEIIQVE-ARDKDLGSNGEVTYSVLTDTQQFAIN-SSTGIVYVAD 890

Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
             LDRE +A +S  ++A                 L + +TL   +V L+D+ND  P F  +
Sbjct: 891  QLDRESKANYSLKIEARDK--------AESGQQLFSVVTL---KVFLDDVNDCSPAFIPS 939

Query: 2850 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
             Y+  V  D  VG+ +  +   D D+G    V YS++
Sbjct: 940  SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976



 Score =  210 bits (534), Expect = 2e-53
 Identities = 230/919 (25%), Positives = 403/919 (43%), Gaps = 129/919 (14%)

Query: 2100 LNGELVYRIEAGAQDRF-----LIHLVTGVIRV-----GNATIDREEQESYRLTVVATDR 2149
            L+ ++ YRI +G ++ F     +I      +R+      +A ++RE Q++Y L V  + R
Sbjct: 75   LSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134

Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEY 2209
            G   L     V I + D+ND RP F     +V++ ES    T +A +TA D D+    E+
Sbjct: 135  GE-DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193

Query: 2210 HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
            +               N+ D F+V+  +G + +   +N +    Y++ +  +D    L  
Sbjct: 194  YYY-----------FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYG 242

Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
             +     AKL V++  +N++ P        + +  +        T   V   D D G NG
Sbjct: 243  NNGVSSTAKLYVHIERINEHAPTI------HVVTHVPFSLEKEPTYAVVTVDDLDDGANG 296

Query: 2330 LVTYTLL---DLVPPGYVQLEDS--SAGKVIANRTVDYEEVHW-LNFTVRASDNGSPPRA 2383
             +    +   D +   ++  E    +  K+   + +D+E   +  N T++A D GSP + 
Sbjct: 297  EIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKC 356

Query: 2384 AEIPVYLEIVDINDNNPI-FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442
            + +          D  PI F++  Y  ++ E  P G ++  V  +         +EY L 
Sbjct: 357  SALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLS 412

Query: 2443 DGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVL 2500
             GE    F INP +G I     L+  KK+ Y L    K+  GD+ +       QV I + 
Sbjct: 413  PGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE--GDLKA-------QVTISIE 463

Query: 2501 DVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDM 2560
            D ND  P+F +P +   V E+ P GTSV+T+ A+D+D+G NG +TYS+    +  F ++ 
Sbjct: 464  DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQ 523

Query: 2561 DSGLVTTQRPL---QSYEKFSLTVVATDGGEPPLWGTTM-LLVEVIDVNDNRPVFVRPPN 2616
             +G+++T   L    S E +   V A+D G P    + + + + + +VNDN P+F +   
Sbjct: 524  FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583

Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
              +  I  + P+  ++  V A D DE     V+Y  +  +GN +  FF ++P SG++Q  
Sbjct: 584  QGV--ISYDFPVGGHITAVSAIDIDE--LELVKYKII--SGN-ELGFFYLNPDSGVLQLK 636

Query: 2677 QRLDRE--SQAVYSLILVASD---LGQPVPY-----------------ETMQPLQVALE- 2713
            + L         ++L + A+D   L  P+                   ET    ++A + 
Sbjct: 637  KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696

Query: 2714 ----------DIDDNEPLFVRPPKGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADE 2758
                      +++D    F    +  P +       + V E  P G  +  +  A DAD 
Sbjct: 697  LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK-AYDADS 755

Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
            G N  V + I+ GN +  F++  + G L VL  +DRE   +  +++  +      P +  
Sbjct: 756  GFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL--YLLNITIYDLGNPQKS- 812

Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
                      + + + + +ED ND  P F +  Y+  +   + +G+E+IQV A D D+G+
Sbjct: 813  ----------SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862

Query: 2878 NSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDL 2937
            N  V YS+L          D+    Q F + S  GI+   D     S   + + I ARD 
Sbjct: 863  NGEVTYSVL---------TDT----QQFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909

Query: 2938 A--GHNDTAIIGIYILRDD 2954
            A  G    +++ + +  DD
Sbjct: 910  AESGQQLFSVVTLKVFLDD 928



 Score =  129 bits (324), Expect = 5e-29
 Identities = 156/592 (26%), Positives = 259/592 (43%), Gaps = 65/592 (10%)

Query: 1024 VGLNAELSYFITGGNVDGKFSV------GYRDAVVRTVVG----LDRETTAAYMLILEAI 1073
            + L+ ++ Y I  G+ +G F         +    +RT  G    L+RE    Y+LI++  
Sbjct: 73   IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132

Query: 1074 DNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGE 1133
              G   +  T    V + VLD+ND RP+F  ++Y  ++ E  P   S+ Q+ ATDAD G 
Sbjct: 133  VRGEDLEAWT---KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189

Query: 1134 FGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-----GPM 1188
             G  +Y     N  + F +H ++G++    R L+ +  + + L + A +  +       +
Sbjct: 190  NGEFYYYFK--NKVDLFSVHPTSGVISLSGR-LNYDEKNRYDLEILAVDRGMKLYGNNGV 246

Query: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG-DGGLVNYR 1247
             S+ ++ V++E IN+ AP      +    L +      +  VV   D D G +G + +  
Sbjct: 247  SSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEP----TYAVVTVDDLDDGANGEIESVS 302

Query: 1248 ILSG---------AEGKFEIDESTGLIITVNYLDYET-KTSYMMNVSATDQAPPFN-QGF 1296
            I++G          EGK+  +     I     +D+E+    Y + + A D+  P      
Sbjct: 303  IVAGDPLDQFFLAKEGKWLNEYK---IKERKQIDWESFPYGYNLTLQAKDKGSPQKCSAL 359

Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGT--EIVRVQAYSIDNLNQITYRFNAYT 1354
             +VYI         ++F    Y+ +I E    G    IV++    ID    + Y+ +   
Sbjct: 360  KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSP-- 413

Query: 1355 STQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDN 1414
              +    FKI+  +G+I     ++  K + Y L V   +G    D   +V I++ D ND+
Sbjct: 414  -GEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG----DLKAQVTISIEDANDH 468

Query: 1415 SPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTND 1474
            +P F      A  + E  PVG  V TV A D D G NG + +S+AS N+         N 
Sbjct: 469  TPEFQQPLYDAY-VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP----FVINQ 523

Query: 1475 SIGEVFVARPLDREEL-DHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFG 1532
              G +     LD E   + Y   V ASD G+P R +  + + + I ++NDN P+ E    
Sbjct: 524  FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583

Query: 1533 YNV-SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISG 1583
              V S +  VGG    V       DI    ++ Y I  GN+   F ++  SG
Sbjct: 584  QGVISYDFPVGGHITAVSA----IDIDELELVKYKIISGNELGFFYLNPDSG 631


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  869 bits (2246), Expect = 0.0
 Identities = 844/2953 (28%), Positives = 1346/2953 (45%), Gaps = 272/2953 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMDN-DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
            I +D PVG S+  + A D+D    L + +       +F +   +GV+ L++P    T  +
Sbjct: 573  IRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ 632

Query: 101  ---FTVEFSVSDHQ---------------------------GVITRKV------------ 118
               ++++ + SD +                           GV+T+              
Sbjct: 633  PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQ 692

Query: 119  --------NIQVGDVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY 169
                    ++    +N   P F +  P S+ + E+ P+ TP+  + ATDPD G  G ++Y
Sbjct: 693  ESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVY 752

Query: 170  SFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
                 ++   F I+   G++TV   LDYE T  Y L V   D   T   S+   L + + 
Sbjct: 753  VIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVK 811

Query: 228  DVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALD 287
            D  D  P F    Y   I E +  GTT+  +T  D D      + YT++S      F+L 
Sbjct: 812  DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLH 869

Query: 288  YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI-DINDNAP 346
             ++G L + G LDRE+      +IL V   E  D  +      + T  I+ + D+NDN+P
Sbjct: 870  PLTGELVVTGHLDRES---EPRYILKV---EARDQPSKGHQLFSVTDLIITLEDVNDNSP 923

Query: 347  EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
            +  +    + + E    G  L  F+   D D    L    EV  V  +  H       + 
Sbjct: 924  QCITEHNRLKVPEDLPPGTVLT-FLDASDPD----LGPAGEVRYVLMDGAHGTFRVDLMT 978

Query: 407  GKADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQ 462
            G   +       LD+E    Y+  L+A++         + + +V +  +NEN + P F+ 
Sbjct: 979  GALILERE----LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS 1034

Query: 463  PLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIMLIAR 520
             ++   + EN   GT V+ V A D+D+G  GE+ YF         FS+++DTG+I  +A 
Sbjct: 1035 FVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094

Query: 521  LDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVT 578
            LD E    + LT++A D G    +    V I V D NDN P   +  +  +++E+ P  T
Sbjct: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154

Query: 579  QLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY 638
             +++L A D DS    ++T++I S +  G +    ++   G++S ++ LD E     ++ 
Sbjct: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFM---IHPVTGLLSTAQQLDRENKDEHILE 1211

Query: 639  LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI--MAGATVLFLNAT 696
            +TV+  D G P L ST  V + + D NDNPP FS   + V + E +  ++   V  L A+
Sbjct: 1212 VTVL--DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVAS 1269

Query: 697  DLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY-ILIVRAVDGGV 753
            DLD         + YS+E S +  F I+  +G ++++S     T  EY IL ++A D G 
Sbjct: 1270 DLDEGLN---GRVTYSIEDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILTIKATDSG- 1322

Query: 754  GHNQKTGIATVNITLLDIN----DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE 809
               Q    A+V + +  I      + P   D  YY   V  T P + +  V++V+   G 
Sbjct: 1323 ---QPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---GR 1376

Query: 810  NGTLVYSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
             G   ++I   +K   + +  TTG I     +  R   + +       + V VTD  R  
Sbjct: 1377 PGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYN-------LTVEVTDGSRT- 1428

Query: 868  LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
                +   +F+ + ++N + P F    +   V +    GV + +V AID D+G + + + 
Sbjct: 1429 --IATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485

Query: 928  R--MPVGMPRMDFLINSSSGVVVTTTELDR-ERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
                  G   + F ++ SSGV+VT  +LD     +++ L V+  D   P K +   +TIH
Sbjct: 1486 HGSQDPGSASL-FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIH 1544

Query: 985  VLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
            V D N   P F    Y  SV + +     ++ +   D D G+NAE+ Y +  GN +G F+
Sbjct: 1545 VEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604

Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
            +     ++     LD+   A + L ++A D G    +    ATV + V   + + PIF +
Sbjct: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQG--SPQWHDLATVIIHVYPSDRSAPIFSK 1662

Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
            S Y   +PE IP G  IL + A    E     V Y +  GN    F ++  +GL+    +
Sbjct: 1663 SEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLIST-QK 1716

Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
             LD E+ SS+ L +   N  +    + V V+V + D ND AP+F +  +    + E A +
Sbjct: 1717 KLDHEKISSYQLKIRGSN--MAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQ-ISEAAPL 1773

Query: 1225 GTSVI-------VVQATDRDSGDGGLVNYRILSGAEGKF-EIDESTGLIITVNYLDYETK 1276
             + ++       V+ A+D D     L+ Y+IL     KF +ID S G +  V+ +DYE+ 
Sbjct: 1774 YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESM 1833

Query: 1277 TSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
             S+   V   DQ  P  F      V I + +  D   +FS   YE AI+  +  G E++ 
Sbjct: 1834 PSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLM 1893

Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDG 1394
            V+A   D+  ++ Y      + +A     I  +TG I+V  L     G    LT+ A DG
Sbjct: 1894 VRASDEDS--EVNYSIKTGNADEAVT---IHPVTGSISV--LNPAFLGLSRKLTIRASDG 1946

Query: 1395 GPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQV 1454
              +  + VK+ +T +   D S +FD     A ++ E+  +  R A V         N  +
Sbjct: 1947 LYQDTALVKISLTQV--LDKSLQFDQDVYWA-AVKEN--LQDRKALVILGAQGNHLNDTL 2001

Query: 1455 VFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQ 1514
             + L +G     F +V +   +    VA   DRE+ D + L V   D  TP R    +++
Sbjct: 2002 SYFLLNGT--DMFHMVQSAGVLQTRGVA--FDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057

Query: 1515 VTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM 1574
            V+I D+NDNPP  +    Y   + +    G  + QV ATD D+G N  ++Y   E     
Sbjct: 2058 VSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT-- 2114

Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF 1634
             FR+D   G+I+ +  P D +  + YHL     D GTP+L +   V VT+   N + P+F
Sbjct: 2115 YFRIDPYLGDISLKK-PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLF 2171

Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVIT 1693
            Q P+Y+V + E   TL T ++  QA      P G  + Y IV    +  F  D   GV+T
Sbjct: 2172 QSPYYKVRVPENI-TLYTPILHTQA----RSPEGLRLIYNIVEEEPLMLFTTDFKTGVLT 2226

Query: 1694 AAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFE 1753
                LDYE S  ++   V ATD     +    S  TV V V D+NDN PTF +       
Sbjct: 2227 VTGPLDYE-SKTKHVFTVRATDT----ALGSFSEATVEVLVEDVNDNPPTFSQ-LVYTTS 2280

Query: 1754 VTEGQPGPR-VWTFLAHDRDSGPNGQVEYSIM-DGDPLGEFVISPVEGVLRVRKDV-ELD 1810
            ++EG P    V   LA D+DSG N  V Y I+ DG  + +F    + G       V ELD
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFF--QINGSTGEMSTVQELD 2338

Query: 1811 RETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
             E    +++ + A D+G PPL+   LV + V DINDN P          +SE +     V
Sbjct: 2339 YEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLV 2398

Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
              V A D DS   +RL + I +GN++R FFIN+++GI+++     +     Y L +   D
Sbjct: 2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD 2458

Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
                  +       + I  ++ N   P F +  Y+AE+ EN+  GT +  L    LA+D 
Sbjct: 2459 GVFRATVP------VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL----LAIDK 2508

Query: 1991 DQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLL 2049
            D   Y  + Y ++    S  F IN +  + T++    +DRE  +  ++ + ++A D G  
Sbjct: 2509 DSGPYGTIDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGGR 2565

Query: 2050 NSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI- 2108
             +   + I + D+NDN P F  +  TV +  N      V+QV A D D G N ++ Y + 
Sbjct: 2566 VAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN 2625

Query: 2109 -EAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
             E   +D   I+ VTGV++V ++ +  E Q +    + A D G    +    V + +   
Sbjct: 2626 PEDLVKDVIEINPVTGVVKVKDSLVGLENQ-TLDFFIKAQDGGPPHWNSLVPVRLQVVPK 2684

Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQ 2227
              S P+F  P+ T S  E    G+ I  + A+    +P +   + G   +        N+
Sbjct: 2685 KVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPES-------NK 2736

Query: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2287
            +  F+++ +TG + V+ PM+ E    Y+     ID  +   + +  V    + + V DVN
Sbjct: 2737 DGVFSLDPDTGVIKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDVN 2791

Query: 2288 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
            DN P F+      Y   + E    GT++I V A+D D G +G V+Y L     PG    E
Sbjct: 2792 DNRPVFEA---DPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS--ADPGSNVHE 2846

Query: 2348 ----DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPR-AAEIPVYLEIVDINDNNPIF 2402
                DS +G +   + +D E     +F V A D+G   + +++  V + I D NDN P F
Sbjct: 2847 LFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRF 2906

Query: 2403 DQPSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEY-SLGDGESKFAINPTTGDIYV 2459
                Y+ +V E+   G ++ T+   DAD    N  +  Y + GD   +F I+   GD + 
Sbjct: 2907 ASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV-GDEWR 2965

Query: 2460 LSS---LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
            +SS   LDRE    Y+L   A D        + + SV V I VLDVND  PQ S+  ++ 
Sbjct: 2966 ISSRKTLDREHTAKYLLRVTASDG-------KFQASVTVEIFVLDVNDNSPQCSQLLYTG 3018

Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK 2576
             V+E+   G  ++ + ATD D   N ++TYSL GPG   F +D  +G +TT   L    K
Sbjct: 3019 KVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERK 3078

Query: 2577 --FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
              F+L   ATDGG         L VE  DVNDN P F   P+   + + +   +++ V  
Sbjct: 3079 DVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFF--PSHCAVAVFDNTTVKTPVAV 3134

Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS 2694
            V+A D D+G N  V YS   +A       F ID  +G+I+  + L    QA   L + AS
Sbjct: 3135 VFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRAS 3190

Query: 2695 DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2754
            DLG P+P  T+  + V++  ++D  P+F+           + VPE +P GT V  +    
Sbjct: 3191 DLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS------VQVPEDAPPGTEVLQLATLT 3244

Query: 2755 DADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTP 2813
                       Y + +GNE+  F L    G L V   LD E    +   ++ S   S   
Sbjct: 3245 RPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSS--- 3298

Query: 2814 PRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
                      ++D+T   V V + D+N+  P+F +  Y+  V  +A VG  ++ V A D 
Sbjct: 3299 --------SSLSDVT--TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDE 3348

Query: 2874 DIGNNSLVFYSIL 2886
            D   NS + YS++
Sbjct: 3349 DGPLNSDITYSLI 3361



 Score =  812 bits (2097), Expect = 0.0
 Identities = 812/2924 (27%), Positives = 1317/2924 (45%), Gaps = 240/2924 (8%)

Query: 24   QVNRL-PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFA 79
            Q+N   P F +HF  + + + E  P+ + + +L A D D   N  LV+ ++       F 
Sbjct: 706  QINHYTPQFEDHFPQS-IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764

Query: 80   VEPDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP 136
            +E +TG++ +  PLD E  + + +  +V D    Q    + + + V D NDNAP F    
Sbjct: 765  IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824

Query: 137  YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE 196
            Y + I E+T VGT I  +   D D    G V Y+   P++ F++    G + V   LD E
Sbjct: 825  YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884

Query: 197  TTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
            +   Y L V A DQ  K   L ++ +L I + DV D  P  I       + E  PPGT +
Sbjct: 885  SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVL 944

Query: 256  RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
              + A D D G    + Y ++ G  +  F +D ++G L L   LD E      G+ L++ 
Sbjct: 945  TFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFER---RAGYNLSLW 1000

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQV 373
                +D   P          ++V+D+N+N   P F S  +   + E +  G  +   I V
Sbjct: 1001 A---SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV---IVV 1054

Query: 374  VDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
              +D++ GL+   + +L  G     F I+  +        I+   PLD E    Y   + 
Sbjct: 1055 AAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM------IQTLAPLDREFASYYWLTVL 1108

Query: 433  ANE--SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
            A +  SVP      +V I + + NDN P  SQ ++  S+ E+  VGTSVL + A D D+ 
Sbjct: 1109 AVDRGSVP-LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSS 1167

Query: 491  TFGEVSYFFSDD--PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGR 546
            + G++++  +       F +   TGL+    +LD E      L +   D G    ++T R
Sbjct: 1168 SKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSR 1227

Query: 547  VRINVLDVNDNVPTFQKDAYVGALRENEPSVT--QLVRLRATDEDSPPNNQITYSIVSAS 604
            V + +LDVNDN P F    +   L E    V+   + RL A+D D   N ++TYSI  + 
Sbjct: 1228 VVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD 1287

Query: 605  AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD- 663
                 F I L    GV+S S      + +     LT+ A D+G PPL+++V + IE    
Sbjct: 1288 E--EAFSIDLVT--GVVSSSSTFTAGEYN----ILTIKATDSGQPPLSASVRLHIEWIPW 1339

Query: 664  --ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSTQ-- 718
               +  P  F +  Y  +V+E       V  ++          G+  +  +++ G  +  
Sbjct: 1340 PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE--------GRPGLFWFNISGGDKDM 1391

Query: 719  -FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL-DINDNHP 776
             F I   +G I     LD   +S Y L V   DG      +T    V+I ++ +IN + P
Sbjct: 1392 DFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG-----SRTIATQVHIFMIANINHHRP 1446

Query: 777  TWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---QPPN--KFYSLNSTTG 831
             + +  Y + + + T P  ++  V A+D D G+  +L+Y+I   Q P     + L+ ++G
Sbjct: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK--SLIYTIHGSQDPGSASLFQLDPSSG 1504

Query: 832  KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
             + T   +     P  H       + V V D    P+K  +   V +++ D N + P F 
Sbjct: 1505 VLVTVGKLDLGSGPSQH------TLTVMVRD-QEIPIK-RNFVWVTIHVEDGNLHPPRFT 1556

Query: 892  NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951
             L + A V + I  G  + QV A+D D G+N  V Y +  G     F IN+  G++    
Sbjct: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ 1616

Query: 952  ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011
            +LD+   A + L V A D G+P     +T+ IHV   +   P F  + Y V + E +P  
Sbjct: 1617 KLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVG 1676

Query: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILE 1071
              ++ ++         +E++Y +  GN DG FS+     ++ T   LD E  ++Y L + 
Sbjct: 1677 SPILLVSAMS-----PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIR 1731

Query: 1072 AIDNGPVGKRHTGTAT---VFVTVLDVNDNRPIFLQSSYEASVPEDIP-------EGHSI 1121
                   G    G  T   V V ++D NDN P+FL+S++   + E  P       + ++ 
Sbjct: 1732 -------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP 1784

Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
              + A+D+D+     + Y+IL       F+I  S G L      +D E   S    V  Y
Sbjct: 1785 FVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI-VSEMDYESMPSFQFCV--Y 1841

Query: 1182 NHDLG-PMRSSVR---VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
             HD G P+  + R   VI++V D+ND  P F++Q Y  + +      G  +++V+A+D D
Sbjct: 1842 VHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY-EVAIVGPIHPGMELLMVRASDED 1900

Query: 1238 SGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAPPFNQ 1294
            S     VNY I +G A+    I   TG I  +N  +L    K    + + A+D      Q
Sbjct: 1901 SE----VNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLYQ 1949

Query: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYT 1354
                V I+L   LD+++QF    Y AA+ ENL     +V + A   ++LN       +Y 
Sbjct: 1950 DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG-NHLNDTL----SYF 2004

Query: 1355 STQAKALFKIDAITGVITVQGLV-DREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDEN 1412
                  +F +    GV+  +G+  DRE+ D + L V V D+  P+  +   V +++ D N
Sbjct: 2005 LLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064

Query: 1413 DNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTT 1472
            DN P+F       + I +    G  +  V A D D G+NG V +  A       +     
Sbjct: 2065 DNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAED-----YTYFRI 2118

Query: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
            +  +G++ + +P D + L+ Y L+V+A D GTP  + +  + VT+   N + P+ +SP+ 
Sbjct: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPY- 2175

Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPP 1592
            Y V V EN+   T ++  +A   + G+   L Y I E    M F  D  +G + T   P 
Sbjct: 2176 YKVRVPENITLYTPILHTQARSPE-GLR--LIYNIVEEEPLMLFTTDFKTG-VLTVTGPL 2231

Query: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
            D E ++ +       D    + S  T V V + D NDN P F Q  Y   + EG     T
Sbjct: 2232 DYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISEGLPA-QT 2289

Query: 1653 SLITIQALDLDEGPNGTVTYAIV--AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
             +I + A D D G N  V+Y IV    ++   F+I+   G ++  +ELDYE +   + + 
Sbjct: 2290 PVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE-AQQHFHVK 2348

Query: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAH 1769
            V A D+       LT  T V+VNV+DINDN P F R  +    V+E    G  V    A 
Sbjct: 2349 VRAMDKG---DPPLTGETLVVVNVSDINDNPPEF-RQPQYEANVSELATCGHLVLKVQAI 2404

Query: 1770 DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMP 1829
            D DS    ++EY I+ G+    F I+   G++ +    +  +   + YNL + A D    
Sbjct: 2405 DPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK--KHLDSSYNLRVGASD---G 2459

Query: 1830 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFN 1889
               +T+ V I   + N   P          ++EN+ V + V  +LA D DSG    + + 
Sbjct: 2460 VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519

Query: 1890 ITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFL 1949
            I        F IN    I T+ + LDRE   E  + I V       R+A   +  + I L
Sbjct: 2520 IINKLASEKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDGGGRVA---FCTVKIIL 2575

Query: 1950 SDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ--S 2007
            +DENDN P F  S Y   +  N    +P+      +LA DAD+   A VTY +       
Sbjct: 2576 TDENDNPPQFKASEYTVSIQSNVSKDSPVI----QVLAYDADEGQNADVTYSVNPEDLVK 2631

Query: 2008 GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITILDDNDN 2065
             + +IN  TGVV V+  ++          L+  + A+D G    NS   + + ++    +
Sbjct: 2632 DVIEINPVTGVVKVKDSLV----GLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVS 2687

Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTG 2123
             P FS    T    E+ P G  +  V A      +   LV     E+     F +   TG
Sbjct: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTG 2747

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
            VI+V    +D E  + Y++ V+A       +     V I + D+ND+RP F        +
Sbjct: 2748 VIKV-RKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVL 2806

Query: 2184 LESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
             E+   GT +  +TAID D   + ++ Y +              N  + FA++  +G + 
Sbjct: 2807 TENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGS--------NVHELFAIDSESGWIT 2858

Query: 2242 VKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYY 2301
                ++ E   TY   +   D+   +   S     A + V++ D NDN P+   F    Y
Sbjct: 2859 TLQELDCETCQTYHFHVVAYDHGQTIQLSS----QALVQVSITDENDNAPR---FASEEY 2911

Query: 2302 MERILEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRT 2359
               ++E + PG  +  +  +D D    N  VT  + +  P G   +       ++ + +T
Sbjct: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971

Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
            +D E        V ASD       A + V + ++D+NDN+P   Q  Y   V EDV  G 
Sbjct: 2972 LDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028

Query: 2420 IILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAK 2478
             IL V+ATD D+   A I YSL G G  +F ++P TG++  L++LDRE+KD + L A A 
Sbjct: 3029 FILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKAT 3088

Query: 2479 DNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDE 2538
            D  G      R     + + V DVND  P+F     + +V++N    T V  + A D D+
Sbjct: 3089 DGGG------RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQ 3142

Query: 2539 GPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP-PLWGTT 2595
            G N ++ YSL       F +D  +G++  ++PLQ        LTV A+D G P PL    
Sbjct: 3143 GANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202

Query: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT 2655
             + V V+ + D  PVF+   +   + + E+ P  + V ++    +     GA +  +   
Sbjct: 3203 TVTVSVVGLEDYLPVFLNTEHS--VQVPEDAPPGTEVLQLATLTRP----GAEKTGYRVV 3256

Query: 2656 AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDI 2715
            +GN     F +D  +G++     LD E+   Y L +  S          +  + V + D+
Sbjct: 3257 SGNEQGR-FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS-SLSDVTTVMVNITDV 3314

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775
            +++ P F + P  +       V E++  G ++  V+ A D D   N+ + Y +  GN+  
Sbjct: 3315 NEHRPQFPQDPYST------RVLENALVGDVILTVS-ATDEDGPLNSDITYSLIGGNQLG 3367

Query: 2776 NFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRV 2834
            +F + P  G L V + LDRE+ + +S  ++A+ +          P L    D+ +Q    
Sbjct: 3368 HFTIHPKKGELQVAKALDREQASSYSLKLRATDS--------GQPPLHEDTDIAIQ---- 3415

Query: 2835 VLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
             + D+ND PPRF +  Y+  V  ++ +GS+++Q++  D D   N
Sbjct: 3416 -VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPEN 3458



 Score =  775 bits (2002), Expect = 0.0
 Identities = 796/2950 (26%), Positives = 1311/2950 (44%), Gaps = 268/2950 (9%)

Query: 40   LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPL 93
            L ISEDT VG+++ +L  +D D++      +G         +  F++ P TG + +   L
Sbjct: 827  LTISEDTEVGTTIAELTTKDADSED-----NGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881

Query: 94   DRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
            DRE++  + ++    D     HQ      + I + DVNDN+P    +   +++PE+ P G
Sbjct: 882  DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941

Query: 149  TPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
            T +  ++A+DPDLG  G V Y     +   F +D   G + + RELD+E    Y L++ A
Sbjct: 942  TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001

Query: 208  TDQDKTRPLSTLANLAIIITDVQDM--DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
            +D  +     TL ++ +I+ DV +    P F +  +   + E+SP GT V ++ A D D 
Sbjct: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061

Query: 266  GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
            G    + Y + +G   + F+++  +G++     LDRE   Y    +L V       DR  
Sbjct: 1062 GLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV-------DRGS 1114

Query: 326  SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
               +  T   I V D NDN P+ + + +  +I E A VG ++ L +   D D +      
Sbjct: 1115 VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV-LQLDAWDPDSSSKGKLT 1173

Query: 386  FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYA 444
            F +   GN    F+I P +        +  A  LD E  D +  ++   +   P     +
Sbjct: 1174 FNI-TSGNYMGFFMIHPVTGL------LSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS 1226

Query: 445  KVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVSYFFSD- 501
            +V + +++ NDN PIFS  L+N+ L E ++  +   V  ++A+D D G  G V+Y   D 
Sbjct: 1227 RVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS 1286

Query: 502  DPDRFSLDKDTGLIMLIARL---DYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
            D + FS+D  TG++   +     +Y +     LTI A D G    +  VR+++    + +
Sbjct: 1287 DEEAFSIDLVTGVVSSSSTFTAGEYNI-----LTIKATDSGQPPLSASVRLHI----EWI 1337

Query: 559  PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS----- 613
            P  +  +   A  E   S T +       E  P N+ +    V       +F+IS     
Sbjct: 1338 PWPRPSSIPLAFDETYYSFTVM-------ETDPVNHMVGVISVEGRPGLFWFNISGGDKD 1390

Query: 614  ----LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF---DEND 666
                + +  G I ++RPLD  + SN    LTV   D        T+   + +F   + N 
Sbjct: 1391 MDFDIEKTTGSIVIARPLDTRRRSN--YNLTVEVTDGSR-----TIATQVHIFMIANINH 1443

Query: 667  NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FR 720
            + P F +  Y V V ++ + G  +L + A D D+ +     S+IY++ GS        F+
Sbjct: 1444 HRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK-----SLIYTIHGSQDPGSASLFQ 1498

Query: 721  INARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
            ++  SG + T   LD  +  S++ L V   D  +    K     V I + D N + P + 
Sbjct: 1499 LDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPI--KRNFVWVTIHVEDGNLHPPRFT 1556

Query: 780  DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTH 837
               Y  ++ +   P +++  V A+D D G N  + YS+   N   F+++N+  G I T  
Sbjct: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII-TLA 1615

Query: 838  AMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVA 897
              LD+ N  PH       + V   D G P       ATV +++   + + P F    +  
Sbjct: 1616 QKLDQANHAPHT------LTVKAEDQGSPQWH--DLATVIIHVYPSDRSAPIFSKSEYFV 1667

Query: 898  EVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRER 957
            E+ E IP G  I  V A+   E     V+Y +  G     F +NS SG++ T  +LD E+
Sbjct: 1668 EIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEK 1722

Query: 958  IAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
            I+ YQL++  S+ AG  T      + + ++D ND  P F  + +   +SE  P    ++ 
Sbjct: 1723 ISSYQLKIRGSNMAGAFTDVM---VVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMD 1779

Query: 1017 LN-------CTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
             N        +D+D   N+ L Y I        F +      +  V  +D E+  ++   
Sbjct: 1780 KNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFC 1839

Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
            +   D G         A V + V DVND+ P F +  YE ++   I  G  +L ++A+D 
Sbjct: 1840 VYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899

Query: 1130 DEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPM 1188
            D      V Y I  GN      IH V+  + +  P  L   R     L + A +   G  
Sbjct: 1900 DS----EVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLY 1948

Query: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI 1248
            + +  V + +  + D++  F Q  Y    ++E      +++++ A      D   ++Y +
Sbjct: 1949 QDTALVKISLTQVLDKSLQFDQDVYWA-AVKENLQDRKALVILGAQGNHLND--TLSYFL 2005

Query: 1249 LSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
            L+G +  F + +S G++ T     D E + ++ + V   D   P       V +++ +  
Sbjct: 2006 LNGTD-MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064

Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKID 1365
            D   +F +  Y   I +    G  + +V A   D      +TY F      +    F+ID
Sbjct: 2065 DNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-----AEDYTYFRID 2119

Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
               G I+++   D +  + Y L V+A DGG P + S  +V +TV   N ++P F  +   
Sbjct: 2120 PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQ-SPYY 2176

Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
             V +PE+  +   +   +A  P+     ++++++        F   TT+   G + V  P
Sbjct: 2177 KVRVPENITLYTPILHTQARSPEGL---RLIYNIVEEEPLMLF---TTDFKTGVLTVTGP 2230

Query: 1485 LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGG 1544
            LD E    ++  V A+D       +  + +V + D+NDNPP   S   Y  S++E +   
Sbjct: 2231 LDYESKTKHVFTVRATDTALGSFSEATV-EVLVEDVNDNPPTF-SQLVYTTSISEGLPAQ 2288

Query: 1545 TAVVQVRATDRDIGINSVLSYYITEGNKDMA--FRMDRISGEIATRPAPPDRERQSFYHL 1602
            T V+Q+ A+D+D G N  +SY I E   D++  F+++  +GE++T     D E Q  +H+
Sbjct: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMST-VQELDYEAQQHFHV 2347

Query: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDL 1662
                 D+G P L+  T V V + D NDN P F+QP YE  + E   T    ++ +QA+D 
Sbjct: 2348 KVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELA-TCGHLVLKVQAIDP 2406

Query: 1663 DEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT----AAKELDYEISHGRYTLIVTATDQCP 1718
            D      + Y I++GN    F I+   G+I+      K LD       Y L V A+D   
Sbjct: 2407 DSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD-----SSYNLRVGASDGV- 2460

Query: 1719 ILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQ 1778
                   +T  V +N  + N   P F +             G +V   LA D+DSGP G 
Sbjct: 2461 -----FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGT 2515

Query: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRE--TIAFYNLTICARDRGMPPLSSTML 1836
            ++Y+I++     +F I+P   +  ++K   LDRE  T     + + ARD G      T  
Sbjct: 2516 IDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGGRVAFCT-- 2570

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE 1896
            V I + D NDN P        ++I  N    S V  VLA DAD G NA +T+++   +  
Sbjct: 2571 VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLV 2630

Query: 1897 RAFF-INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
            +    IN  TG+V V   L    +    L   +K     P        + L  +  +  +
Sbjct: 2631 KDVIEINPVTGVVKVKDSL--VGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP-KKVS 2687

Query: 1956 HPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINS 2014
             P F++  Y     E+ P G+ + ++         D  IY++V      + + G+F ++ 
Sbjct: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDP 2744

Query: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATL 2074
             TGV+ VR  +  D E+     ++++        + S   + I + D NDNRP F     
Sbjct: 2745 DTGVIKVRKPM--DHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPY 2802

Query: 2075 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA----GAQDRFLIHLVTGVIRVGNA 2130
               L EN P G SV+QVTA D+D+G +G++ YR+ A       + F I   +G I     
Sbjct: 2803 KAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQE 2862

Query: 2131 TIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189
             +D E  ++Y   VVA D G T+ LS  A+V + I D ND+ P F +     SV+E++EP
Sbjct: 2863 -LDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEP 2921

Query: 2190 GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249
            G ++A +  +D D++ +       I   D   +   +Q        +   +  +  ++RE
Sbjct: 2922 GELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG------DEWRISSRKTLDRE 2975

Query: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309
              A Y + ++  D      + SV+V      + VLDVNDN+PQ        Y  ++ E  
Sbjct: 2976 HTAKYLLRVTASDGKF---QASVTVE-----IFVLDVNDNSPQCSQL---LYTGKVHEDV 3024

Query: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWL 2368
             PG  ++ V+A D D   N  +TY+L     PG  + + D   G++     +D E     
Sbjct: 3025 FPGHFILKVSATDLDTDTNAQITYSLHG---PGAHEFKLDPHTGELTTLTALDRERKDVF 3081

Query: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
            N   +A+D G   R+ +  + L + D+NDN P F       AVF++  V T +  V A D
Sbjct: 3082 NLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARD 3139

Query: 2429 ADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
             D G  A + YSL D  E  F+I+ TTG I +   L    +    LT  A D    +  +
Sbjct: 3140 PDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199

Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS 2547
                   V + V+ + D  P F   + S  V E+ P GT V+ +    +   P  E T  
Sbjct: 3200 TLGT---VTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR---PGAEKTGY 3253

Query: 2548 LEGPGVEA--FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 2603
                G E   F +D  +G++     L  ++  K+ L++  +      L   T ++V + D
Sbjct: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITD 3313

Query: 2604 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEF 2663
            VN++RP F + P  T   + E   +   +  V ATD+D  LN  + YS +   G      
Sbjct: 3314 VNEHRPQFPQDPYST--RVLENALVGDVILTVSATDEDGPLNSDITYSLI---GGNQLGH 3368

Query: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFV 2723
            F I P  G +Q A+ LDRE  + YSL L A+D GQP  +E    + + + D++DN P F 
Sbjct: 3369 FTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTD-IAIQVADVNDNPPRFF 3427

Query: 2724 RPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF-IAAGNEEKNFHLQPD 2782
            +    +      TV E+SP G+ V  +  + D D   N   Y F I  GN    F + PD
Sbjct: 3428 QLNYST------TVQENSPIGSKVLQLILS-DPDSPENGPPYSFRITKGNNGSAFRVTPD 3480

Query: 2783 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842
            G L+    L R  +  +   ++AS   S  PP             +L  VRV + + +  
Sbjct: 3481 GWLVTAEGLSRRAQEWYQLQIQASD--SGIPPLS-----------SLTSVRVHVTEQSHY 3527

Query: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVG 2902
             P     E    V  D   G  + ++ A D D      + YS+           + E +G
Sbjct: 3528 APSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYSLA----------EEETLG 3575

Query: 2903 QVFTMGSMDG 2912
            + F++G+ DG
Sbjct: 3576 RHFSVGAPDG 3585



 Score =  747 bits (1929), Expect = 0.0
 Identities = 770/2805 (27%), Positives = 1263/2805 (45%), Gaps = 285/2805 (10%)

Query: 236  FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR-GIGYTIVSGNTNSIFALD-YISGVL 293
            F +  Y+  IYE+S P T V     +      P+  + Y I+SG+  ++F  + Y+ G  
Sbjct: 33   FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92

Query: 294  TL---------NGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDN 344
                         LL+RE       + L ++ TE        +    T   + ++D ND 
Sbjct: 93   CFLRIRTKSSNTALLNRE---VRDSYTLIIQATEKT-----LELEALTRVVVHILDQNDL 144

Query: 345  APEFNSSEYSVAITELAQVGFALPL---FIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS 401
             P F+   Y V I+E       +PL     +V   D +LG N+ F  Y     S  F I 
Sbjct: 145  KPLFSPPSYRVTISE------DMPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIH 197

Query: 402  PTS----VQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
            PTS    V GK ++  R    L    VDR          + +  G+  +   +++     
Sbjct: 198  PTSGVVTVAGKLNVTWRGKHELQVLAVDRM-------RKISEGNGFGSLAALVVHVE--- 247

Query: 458  PIFSQPLYNISLY---ENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR-------FS 507
            P   +P    S+     +   GT+  TVL   N +G   E       DP +       ++
Sbjct: 248  PALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYA 307

Query: 508  LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVR-INVLDVNDNVPTFQKDAY 566
               +  L+ +      E +  F L++ AR G G     ++R  ++     +   F+K  Y
Sbjct: 308  RSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVY 367

Query: 567  VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626
               L E  P  +++V +R T   + PN Q      S +         L    G+I+ ++ 
Sbjct: 368  RVQLSEFSPPGSRVVMVRVTP--AFPNLQYVLKPSSENV-----GFKLNARTGLITTTKL 420

Query: 627  LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA 686
            +D+   ++  +++        +P   STV V I++ D N++ P F++ +Y  ++ ENI  
Sbjct: 421  MDFHDRAHYQLHIRT------SPGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPP 473

Query: 687  GATVLFLNATDLDRSREYGQES-IIYSLEG--STQFRINARSGEITTTSLLDRE-TKSEY 742
            G +VL + ATD    R++G+   + YS+ G  +  F I+   G I+T+  +D E  K  Y
Sbjct: 474  GTSVLAVTATD----RDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIY 529

Query: 743  ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
               VRA D G    ++  + ++ + L ++NDN P +++     ++ +  P    + T+ A
Sbjct: 530  TFRVRASDWGSPFRREKEV-SIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588

Query: 803  VDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS- 859
            +D D  +N  L Y I   N  +++ LN  +G I      ++     P    L  KI  S 
Sbjct: 589  IDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSL--KITASD 644

Query: 860  --------------VTD--------CGRPPLKATSSATV--FVNLLDLNDNDPTFQNL-- 893
                          V D        C +  +    + T+  F+ L +   +D  F +L  
Sbjct: 645  GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704

Query: 894  --------------PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
                          P   +VLE +P    + ++ A D D G NG + Y +  G     F 
Sbjct: 705  YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764

Query: 940  INSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV 999
            I   +G++     LD E    Y L V   D GTP KSS   LT++V D ND  P F P  
Sbjct: 765  IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824

Query: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLD 1059
            Y +++SED      +  L   D D   N  + Y +   +   KFS+      +     LD
Sbjct: 825  YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLD 882

Query: 1060 RETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
            RE+   Y+L +EA D    G +      + +T+ DVNDN P  +       VPED+P G 
Sbjct: 883  RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942

Query: 1120 SILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
             +  L A+D D G  G V Y ++ G HG  FR+ +  G L+   R LD ER + + L + 
Sbjct: 943  VLTFLDASDPDLGPAGEVRYVLMDGAHG-TFRVDLMTGALIL-ERELDFERRAGYNLSLW 1000

Query: 1180 AYNHDLGPMRSSV-RVIVYVEDINDEA-PVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
            A +      R ++  V V V D+N+   P        +  ++E +  GT VIVV A D D
Sbjct: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060

Query: 1238 SGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
            SG  G + Y + +G     F I++ TG+I T+  LD E  + Y + V A D+        
Sbjct: 1061 SGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV 1120

Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTST 1356
              VYI + +  D   Q S A +  +I E+  +GT ++++ A+  D+ ++    FN  TS 
Sbjct: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-ITSG 1179

Query: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNS 1415
                 F I  +TG+++    +DRE  D + L V V D+G P + ST +V + +LD NDN 
Sbjct: 1180 NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNP 1239

Query: 1416 PRFDFTSDSAVSIPED-CPVGQ-RVATVKAWDPDAGSNGQVVFSLA-SGNIAGAFEIVTT 1472
            P F     + V +PE   PV    V  + A D D G NG+V +S+  S   A + ++VT 
Sbjct: 1240 PIFSHKLFN-VRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG 1298

Query: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI----- 1527
              S    F A        ++ IL + A+D G PP      L +  +     P  I     
Sbjct: 1299 VVSSSSTFTAG-------EYNILTIKATDSGQPPLSASVRLHIEWIPW-PRPSSIPLAFD 1350

Query: 1528 ESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
            E+ + + V   + V     V+ V       G   +  + I+ G+KDM F +++ +G I  
Sbjct: 1351 ETYYSFTVMETDPVNHMVGVISVE------GRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404

Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
               P D  R+S Y+L   V D G+ T++   H+++ I + N + P F +  YEV + +  
Sbjct: 1405 -ARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQ-- 1459

Query: 1648 DTL-NTSLITIQALDLDEGPNGTVT-YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
            DT+    L+ +QA+D D+G +   T +        + F++D   GV+    +LD      
Sbjct: 1460 DTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519

Query: 1706 RYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPR-DYEGPFEVTEGQPGPRV 1763
            ++TL V   DQ  PI      +   V ++V D N + P F +  YE     T   PG  +
Sbjct: 1520 QHTLTVMVRDQEIPI----KRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIA-PGTEL 1574

Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
                A D D G N +V YS++ G+  G F I+ + G++ + +  +LD+   A + LT+ A
Sbjct: 1575 LQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ--KLDQANHAPHTLTVKA 1632

Query: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
             D+G P       V I V   + + P+       + I E+ PV S +  V A        
Sbjct: 1633 EDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP----- 1687

Query: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
            + +T+ +  GN++  F +N+ +G+++  + LD E+I  Y+L I       N   A  D  
Sbjct: 1688 SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDV- 1742

Query: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNG---PILALDADQDIYAVVTY 2000
            ++++ + DENDN P+F KST+  ++ E +P  + +   N     I A D+D++  +++ Y
Sbjct: 1743 MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802

Query: 2001 QLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAHL 2055
            ++L  ++   F I+ S G +T    ++ + +  S P  +  +   D G         A +
Sbjct: 1803 KILEPEALKFFKIDPSMGTLT----IVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQV 1858

Query: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
            +I + D ND+ P FS     V ++    PG  +L V A+DEDS +N    Y I+ G A +
Sbjct: 1859 IIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADE 1914

Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
               IH VTG I V N         S +LT+ A+D        TA+V I +  + D   +F
Sbjct: 1915 AVTIHPVTGSISVLNPAF---LGLSRKLTIRASDG---LYQDTALVKISLTQVLDKSLQF 1968

Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVN 2234
               +   +V E+ +    +  + A  + LN  L Y ++             N  D F + 
Sbjct: 1969 DQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLL-------------NGTDMFHMV 2015

Query: 2235 INTGSVMVKS-PMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
             + G +  +    +RE   T+E+ + V DN +  P+R   V    + V++ DVNDN P+F
Sbjct: 2016 QSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQR---VAQGLVRVSIEDVNDNPPKF 2070

Query: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
            K      Y   I +G  PG  L  V+A D D G NG VTY   +     Y ++ D   G 
Sbjct: 2071 KHLP---YYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE--DYTYFRI-DPYLGD 2124

Query: 2354 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE 2413
            +   +  DY+ ++  +  V A D G+P   +E  V + +   N +NP+F  P Y+  V E
Sbjct: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPE 2182

Query: 2414 DVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLDREKKDHY 2471
            ++ + T IL    T A S     + Y++ + E    F  +  TG + V   LD E K  +
Sbjct: 2183 NITLYTPIL---HTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKH 2239

Query: 2472 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 2531
            + T  A D       +  E +V+V+++  DVND  P FS+  ++TS+ E  PA T VI +
Sbjct: 2240 VFTVRATDT---ALGSFSEATVEVLVE--DVNDNPPTFSQLVYTTSISEGLPAQTPVIQL 2294

Query: 2532 MATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDG 2586
            +A+DQD G N +++Y +   G +    F ++  +G ++T + L  ++ + F + V A D 
Sbjct: 2295 LASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDK 2354

Query: 2587 GEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 2646
            G+PPL G T+++V V D+NDN P F +P      ++ E       V +V A D D     
Sbjct: 2355 GDPPLTGETLVVVNVSDINDNPPEFRQPQYEA--NVSELATCGHLVLKVQAIDPDS--RD 2410

Query: 2647 AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQ 2706
              R  +L  +GN+D  FF I+  SG+I       +   + Y+L + ASD      +    
Sbjct: 2411 TSRLEYLILSGNQDRHFF-INSSSGIISMFNLCKKHLDSSYNLRVGASD----GVFRATV 2465

Query: 2707 PLQVALEDIDDNEPLFVRPPKGSPQYQL----LTVPEHSPRGTLVGNVTGAVDADEGPNA 2762
            P+ +   + +          K SP++Q       + E++  GT V ++  A+D D GP  
Sbjct: 2466 PVYINTTNAN----------KYSPEFQQHLYEAELAENAMVGTKVIDLL-AIDKDSGPYG 2514

Query: 2763 IVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
             + Y I      + F + P+G +  L+ LDRE        +K  +              D
Sbjct: 2515 TIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMAR-------------D 2561

Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
                +    V+++L D ND PP+F  +EYT  + ++    S +IQVLA DAD G N+ V 
Sbjct: 2562 GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVT 2621

Query: 2883 YSILAIHYFRALANDSEDVGQVFTMGSMDGI-LRTFDLFMAYSPG 2926
            YS+      + +   +   G V    S+ G+  +T D F+    G
Sbjct: 2622 YSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDG 2666



 Score =  740 bits (1911), Expect = 0.0
 Identities = 773/2921 (26%), Positives = 1253/2921 (42%), Gaps = 265/2921 (9%)

Query: 93   LDRETKSEFTVEFSVSDHQ---GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
            L+RE +  +T+    ++       +TR V + + D ND  P F    Y V I E+ P+ +
Sbjct: 107  LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165

Query: 150  PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
            PI  V ATD DLG      Y+F   S+ FAI    G+VTV  +L+      ++L V A  
Sbjct: 166  PICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAV- 224

Query: 210  QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP---PGTTVRIITAIDQDKG 266
             D+ R +S       +   V  ++P     P   ++    P    GTT   +  +D +  
Sbjct: 225  -DRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATV-LVDANSS 282

Query: 267  RPRGIGYTIVSGNTNSIFAL--DYI-SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
                    +V G+    F     Y  S   +L  + D     Y HGF L++   +     
Sbjct: 283  GAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL---QARSGS 339

Query: 324  TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
             P   +    F++    +  ++ +F  + Y V ++E +  G  + + ++V     NL   
Sbjct: 340  GPYFYSQIRGFHLPPSKL--SSLKFEKAVYRVQLSEFSPPGSRV-VMVRVTPAFPNL--- 393

Query: 384  SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---FDLFANESVPDH 440
                          +++ P+S      +  R  +    + +D +D   + L    S P  
Sbjct: 394  -------------QYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-PGQ 439

Query: 441  VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
                 V I +++ N++ P+F++  Y+ +L EN+  GTSVL V ATD D G  G V+Y  +
Sbjct: 440  AS-TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA 498

Query: 501  DDPD-RFSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGGG---EETTGRVRINVLDVN 555
                  FS+D   G+I     +DYEL++R +T  + A D G     E    + + + ++N
Sbjct: 499  GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558

Query: 556  DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
            DN P F++    G++R++ P    ++ + A D D   N  + Y IVS +    YFD++ +
Sbjct: 559  DNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNEL-EYFDLNHF 615

Query: 616  EGYGVISVSRPLDYEQISNGLIY-LTVMAMDAGN----PPLNST--------VPVT---- 658
               GVIS+ RP           Y L + A D  N      LN T        VPVT    
Sbjct: 616  S--GVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKT 673

Query: 659  ----------------------------IEVFDENDNPPTFSKP-AYFVSVVENIMAGAT 689
                                        +  +  N   P F       + V+E++     
Sbjct: 674  GVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTP 733

Query: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVR 747
            +  L ATD D    +  + +    +G+ +  F I   +G +T  + LD E  + YIL V 
Sbjct: 734  LARLAATDPDAG--FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVT 791

Query: 748  AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
              D G        + TVN+   D NDN P +    Y + + E T   + +  +   D D 
Sbjct: 792  VYDLGTPQKSSWKLLTVNVK--DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADS 849

Query: 808  GENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
             +NG + Y++  P + +SL+  TG++  T   LDR      E+E    + V   D     
Sbjct: 850  EDNGRVRYTLLSPTEKFSLHPLTGELVVT-GHLDR------ESEPRYILKVEARDQPSKG 902

Query: 868  LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
             +  S   + + L D+NDN P         +V E +P G  +  + A D D G  G V Y
Sbjct: 903  HQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY 962

Query: 928  RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTP-TKSSTSTLTIHVL 986
             +  G     F ++  +G ++   ELD ER A Y L + ASD G P  + +   + + VL
Sbjct: 963  VLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021

Query: 987  DVND--ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
            DVN+    P F   V+   V E+ P   +V+ +   D+D GL+ EL YF+  G     FS
Sbjct: 1022 DVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFS 1081

Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
            +     +++T+  LDRE  + Y L + A+D G V    +    V++ V D NDN P   Q
Sbjct: 1082 INQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--SSVTEVYIEVTDANDNPPQMSQ 1139

Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
            + +  S+ ED P G S+LQL A D D    G++ + I  GN+   F IH   GLL    +
Sbjct: 1140 AVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTA-Q 1198

Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETAG 1223
             LDRE    H+L V   ++    ++S+ RV+V + D+ND  P+F+ + ++ RL  R +  
Sbjct: 1199 QLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPV 1258

Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
                V  + A+D D G  G V Y I    E  F ID  TG++ + +   +      ++ +
Sbjct: 1259 SPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTI 1316

Query: 1284 SATDQAPPFNQGFCSVYITLL---NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSI 1340
             ATD   P       ++I  +         + F    Y   ++E   +   +  +     
Sbjct: 1317 KATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR 1376

Query: 1341 DNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS 1400
              L    + FN  +       F I+  TG I +   +D  +   Y LTV   DG   + +
Sbjct: 1377 PGL----FWFN-ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIAT 1431

Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
             V +++ + + N + P+F   +   V +P+D   G  +  V+A D D G +  +++++  
Sbjct: 1432 QVHIFM-IANINHHRPQF-LETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHG 1487

Query: 1461 GNIAGAFEIVTTNDSIGEVFVARPLD-REELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
                G+  +   + S G +     LD       + L V+  D+  P ++    + + + D
Sbjct: 1488 SQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVED 1547

Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMD 1579
             N +PP   +   Y  SV + +  GT ++QVRA D D G+N+ + Y + +GN +  F ++
Sbjct: 1548 GNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNIN 1606

Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY 1639
             + G I T     D+   + + L    ED+G+P       V + +   + +AP+F +  Y
Sbjct: 1607 ALLG-IITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEY 1665

Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
             V + E    + + ++ + A+   E     VTY +  GN    F ++ + G+I+  K+LD
Sbjct: 1666 FVEIPES-IPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLD 1719

Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQ 1758
            +E     Y L +  ++          +   V+V++ D NDN P F +  + G  +++E  
Sbjct: 1720 HE-KISSYQLKIRGSNMAGAF-----TDVMVVVDIIDENDNAPMFLKSTFVG--QISEAA 1771

Query: 1759 P--------GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELD 1810
            P            +   A D D   N  + Y I++ + L  F I P  G L +    E+D
Sbjct: 1772 PLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVS--EMD 1829

Query: 1811 RETIAFYNLTICARDRGMPPLSS--TMLVGIRVLDINDNDPVLLNLPMNITISENSPVSS 1868
             E++  +   +   D+G P L +     V I V D+ND+ P        + I        
Sbjct: 1830 YESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGM 1889

Query: 1869 FVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRP--LDRERIPEYKLTI 1926
             +  V ASD DS  N    ++I  GN + A  I+  TG ++V  P  L   R    KLTI
Sbjct: 1890 ELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLTI 1941

Query: 1927 SVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPIL 1986
               D         +D  L+ I L+   D    F +  Y A V EN      L +L     
Sbjct: 1942 RASDG------LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--- 1992

Query: 1987 ALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDI 2046
                   +   ++Y LL   + +F +  S GV+  R GV  DRE       EL +   D 
Sbjct: 1993 ---QGNHLNDTLSYFLLNG-TDMFHMVQSAGVLQTR-GVAFDRE--QQDTHELAVEVRDN 2045

Query: 2047 GLLNSTAHLL--ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGEL 2104
                  A  L  ++I D NDN P F        + +   PG  + QV+ATDED G NG +
Sbjct: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105

Query: 2105 VYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILI 2164
             Y   A     F I    G I +     D +    Y L V+A D GT  L     V + +
Sbjct: 2106 TYEF-AEDYTYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV 2163

Query: 2165 DDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLV 2224
               N S P F +P   V V E+    T I +  A   +   +L Y+IV      + + L+
Sbjct: 2164 R--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GLRLIYNIV------EEEPLM 2214

Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
                  F  +  TG + V  P++ E    +  T+   D A        S   A + V V 
Sbjct: 2215 -----LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALG------SFSEATVEVLVE 2263

Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPPG 2342
            DVNDN P F       Y   I EG    T +I + A D D G N  V+Y +++       
Sbjct: 2264 DVNDNPPTFSQL---VYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK 2320

Query: 2343 YVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIF 2402
            + Q+ + S G++   + +DYE     +  VRA D G PP   E  V + + DINDN P F
Sbjct: 2321 FFQI-NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEF 2379

Query: 2403 DQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVL 2460
             QP Y+  V E    G ++L V A D DS + + +EY +  G+ +  F IN ++G I + 
Sbjct: 2380 RQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMF 2439

Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
            +   +     Y L   A D            +V V I   + N   P+F +  +   + E
Sbjct: 2440 NLCKKHLDSSYNLRVGASDGV-------FRATVPVYINTTNANKYSPEFQQHLYEAELAE 2492

Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQ---RPLQSYEK 2576
            N   GT VI ++A D+D GP G + Y++      E F ++ +  + T Q   R   +   
Sbjct: 2493 NAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERV 2552

Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
             ++ V+A DGG    + T  ++  + D NDN P F    +   + I+  +   S V +V 
Sbjct: 2553 IAIKVMARDGGGRVAFCTVKII--LTDENDNPPQF--KASEYTVSIQSNVSKDSPVIQVL 2608

Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDL 2696
            A D DEG N  V YS       +D     I+P++G+++    L           + A D 
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKD--VIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD- 2665

Query: 2697 GQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDA 2756
            G P  + ++ P+++ +       P  V  PK S      + PE  P G+ +G V      
Sbjct: 2666 GGPPHWNSLVPVRLQV------VPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ 2719

Query: 2757 DEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPR 2815
            D    ++V       N++  F L PD G + V + +D E   ++   V A   ++     
Sbjct: 2720 DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN----- 2774

Query: 2816 GPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADI 2875
                  D+V   +L  V + + D+ND  P F    Y A +  +  VG+ +IQV A+D D 
Sbjct: 2775 -----TDVV---SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDT 2826

Query: 2876 GNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT 2916
            G +  V Y        R  A+   +V ++F + S  G + T
Sbjct: 2827 GRDGQVSY--------RLSADPGSNVHELFAIDSESGWITT 2859



 Score =  734 bits (1895), Expect = 0.0
 Identities = 806/2967 (27%), Positives = 1300/2967 (43%), Gaps = 297/2967 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEP 82
            N  P F    +D  L   E+ P G+SV  + A D D   N  + + ++G +A  F +++P
Sbjct: 453  NHAPLFNRSSYDGTL--DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPF-SIDP 509

Query: 83   DTGVVWLRQPLDRE-TKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPY 137
              G++   +P+D E  K  +T     SD      R+    + +Q+ ++NDN P F     
Sbjct: 510  YLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNC 569

Query: 138  SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIR---ELD 194
            +  I ++ PVG  I  ++A D D               ++F ++   G++++ R    L 
Sbjct: 570  TGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLT 629

Query: 195  YETTQAYQLTVNATDQ-------------------------DKTRPLSTLANLAIIITDV 229
                 +Y L + A+D                          DKT  L+      +    +
Sbjct: 630  AGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGL 689

Query: 230  QDM---DPIFINL----------------PYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
            Q+    D  F +L                P S ++ E  P  T +  + A D D G    
Sbjct: 690  QNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGK 749

Query: 271  IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
            + Y I  GN    F ++  +G+LT+   LD E    ++ +IL V   +L   +  S   +
Sbjct: 750  LVYVIADGNEEGCFDIELETGLLTVAAPLDYE---ATNFYILNVTVYDLGTPQKSSWKLL 806

Query: 331  TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
            T    + V D NDNAP F    Y + I+E  +VG  +    ++  KD +   N     Y 
Sbjct: 807  T----VNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI---AELTTKDADSEDNGRVR-YT 858

Query: 391  VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE---------SVPDHV 441
            + + +  F + P + +      + V   LD E+  RY   + A +         SV D +
Sbjct: 859  LLSPTEKFSLHPLTGE------LVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI 912

Query: 442  GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
                  ITL + NDN P        + + E++  GT +  + A+D D G  GEV Y   D
Sbjct: 913  ------ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD 966

Query: 502  DP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDN 557
                 F +D  TG ++L   LD+E    + L++ A DGG      T   V + VLDVN+N
Sbjct: 967  GAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNEN 1026

Query: 558  V--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
            +  P F    + G ++EN PS TQ++ + A D+DS  + ++ Y + + +   ++   S+ 
Sbjct: 1027 LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF---SIN 1083

Query: 616  EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA 675
            +  G+I    PLD E  S    +LTV+A+D G+ PL+S   V IEV D NDNPP  S+  
Sbjct: 1084 QDTGMIQTLAPLDREFAS--YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV 1141

Query: 676  YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLD 735
            ++ S+ E+   G +VL L+A D D S +      I S      F I+  +G ++T   LD
Sbjct: 1142 FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLD 1201

Query: 736  RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDS 795
            RE K E+IL V  +D G    + T    V I  LD+NDN P +    + + L E   P S
Sbjct: 1202 RENKDEHILEVTVLDNGEPSLKSTSRVVVGI--LDVNDNPPIFSHKLFNVRLPERLSPVS 1259

Query: 796  --DVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
               V  +VA D D G NG + YSI+  + + +S++  TG + ++      E         
Sbjct: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGE--------- 1310

Query: 853  MRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
               + +  TD G+PPL A+    + ++     +     F    +   V+E  P    +  
Sbjct: 1311 YNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDP----VNH 1366

Query: 912  VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG 971
            +V +   EG  GL  + +  G   MDF I  ++G +V    LD  R + Y L V  +D  
Sbjct: 1367 MVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG- 1425

Query: 972  TPTKSSTSTLTIHVL---DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
                S T    +H+    ++N   P F    Y V V +D      ++ +   D D G   
Sbjct: 1426 ----SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKG--K 1479

Query: 1029 ELSYFITGGNVDGKFSVGYRD---AVVRTVVGLDRET-TAAYMLILEAIDNGPVGKRHTG 1084
             L Y I G    G  S+   D    V+ TV  LD  +  + + L +   D     KR+  
Sbjct: 1480 SLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539

Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG 1144
              T+ V   D N + P F Q  YEASVP+ I  G  +LQ++A DAD G    V Y +L G
Sbjct: 1540 WVTIHVE--DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG 1597

Query: 1145 NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE 1204
            N    F I+   G++    + LD+  ++ H L V+A +           VI++V   +  
Sbjct: 1598 NSEGFFNINALLGIITLAQK-LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656

Query: 1205 APVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTG 1263
            AP+F++ +Y  + + E+  +G+ +++V A          V Y +  G  +G F ++  +G
Sbjct: 1657 APIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSG 1710

Query: 1264 LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASY----- 1318
            LI T   LD+E  +SY + +  ++ A  F      V + +++E D A  F  +++     
Sbjct: 1711 LISTQKKLDHEKISSYQLKIRGSNMAGAFTD--VMVVVDIIDENDNAPMFLKSTFVGQIS 1768

Query: 1319 EAAILENLALGTE----IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
            EAA L ++ +       ++       +  + + Y+       +A   FKID   G +T+ 
Sbjct: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKI---LEPEALKFFKIDPSMGTLTIV 1825

Query: 1375 GLVDREKGDFYTLTVVADDGGPKV---DSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
              +D E    +   V   D G  V       +V I V D ND+ PRF       V+I   
Sbjct: 1826 SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFS-EQIYEVAIVGP 1884

Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP----LDR 1487
               G  +  V+A D D+    +V +S+ +GN   A E VT +   G + V  P    L R
Sbjct: 1885 IHPGMELLMVRASDEDS----EVNYSIKTGN---ADEAVTIHPVTGSISVLNPAFLGLSR 1937

Query: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
            +      L + ASD      +   ++++++  + D     +    Y  +V EN+    A+
Sbjct: 1938 K------LTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDV-YWAAVKENLQDRKAL 1987

Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
            V + A      +N  LSY++  G  DM F M + +G + TR    DRE+Q  + L   V 
Sbjct: 1988 VILGAQGNH--LNDTLSYFLLNGT-DM-FHMVQSAGVLQTRGVAFDREQQDTHELAVEVR 2043

Query: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
            D  TP   A   V V+I D NDN P F+   Y  ++ +G +     L  + A D D G N
Sbjct: 2044 DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEP-GDVLFQVSATDEDLGTN 2102

Query: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTST 1727
            G VTY          FRID ++G I+  K  DY+ +  +Y L V A D     +  L S 
Sbjct: 2103 GAVTYEFAED--YTYFRIDPYLGDISLKKPFDYQ-ALNKYHLKVIARDGG---TPSLQSE 2156

Query: 1728 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNG-QVEYSIMDG 1786
              VLV V   N + P F    + P+          ++T + H +   P G ++ Y+I++ 
Sbjct: 2157 EEVLVTVR--NKSNPLF----QSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEE 2210

Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
            +PL  F      GVL V     LD E+   +  T+ A D  +   S    V + V D+ND
Sbjct: 2211 EPLMLFTTDFKTGVLTVTG--PLDYESKTKHVFTVRATDTALGSFSEA-TVEVLVEDVND 2267

Query: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE--RAFFINAT 1904
            N P    L    +ISE  P  + V  +LASD DSG N  +++ I     +  + F IN +
Sbjct: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGS 2327

Query: 1905 TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTY 1964
            TG ++  + LD E    + + +   D  + P        L+++ +SD NDN P F +  Y
Sbjct: 2328 TGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGE---TLVVVNVSDINDNPPEFRQPQY 2384

Query: 1965 QAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRS 2023
            +A V E +  G     L   + A+D D    + + Y +L G Q   F INSS+G++++ +
Sbjct: 2385 EANVSELATCGH----LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFN 2440

Query: 2024 GVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCP 2083
              +  +   S     L + A D G+  +T  + I   + N   P F        L EN  
Sbjct: 2441 --LCKKHLDSS--YNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAM 2495

Query: 2084 PGFSVLQVTATDEDSGLNGELVYR-IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRL 2142
             G  V+ + A D+DSG  G + Y  I   A ++F I+    +  +     +   +    +
Sbjct: 2496 VGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAI 2555

Query: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
             V+A D G      T  V I++ D ND+ P+F     TVS+  +    + +  + A D D
Sbjct: 2556 KVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDAD 2613

Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
                 E     +    + + LV   +D   +N  TG V VK      LV     TL    
Sbjct: 2614 -----EGQNADVTYSVNPEDLV---KDVIEINPVTGVVKVKD----SLVGLENQTLDFFI 2661

Query: 2263 NASD--LPERSVSVPNAKLTVNVLDVNDNTPQF-KPFGITYYMERILEGATPGTTLIAVA 2319
             A D   P  +  VP   + + V+    + P+F +P       E + EG+  G  + AVA
Sbjct: 2662 KAQDGGPPHWNSLVP---VRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIG-IVKAVA 2717

Query: 2320 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGS 2379
            A DP   +  LV  T  +    G   L D   G +   + +D+E        V A    +
Sbjct: 2718 AQDP--VIYSLVRGTTPESNKDGVFSL-DPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN 2774

Query: 2380 PPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEY 2439
                + + V +++ D+NDN P+F+   Y+  + E++PVGT ++ VTA D D+G    + Y
Sbjct: 2775 TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSY 2834

Query: 2440 SL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 2494
             L      +    FAI+  +G I  L  LD E    Y    +A D+   +   +  +   
Sbjct: 2835 RLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTI---QLSSQAL 2891

Query: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNGELT-YSLEGPG 2552
            V + + D ND  P+F+  ++  SV EN   G  V T+   D D    N ++T Y  EG  
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951

Query: 2553 VEAFHVDM--DSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
            +  F +    D   +++++ L  +   K+ L V A+DG       +  + + V+DVNDN 
Sbjct: 2952 LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDN- 3007

Query: 2609 PVFVRPPNGTILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 2665
                 P    +L+   + E++     + +V ATD D   N  + YS      +     F 
Sbjct: 3008 ----SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHE----FK 3059

Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
            +DP +G + T   LDRE + V++L+  A+D G          + + +ED++DN P F   
Sbjct: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATDGG---GRSCQADITLHVEDVNDNAPRFF-- 3114

Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGC 2784
                P +  + V +++   T V  V  A D D+G NA V Y +   + E +F +    G 
Sbjct: 3115 ----PSHCAVAVFDNTTVKTPVA-VVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGV 3168

Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
            + + + L    +A     V+AS   +      P P        TL  V V +  + D  P
Sbjct: 3169 IRLEKPLQVRPQAPLELTVRASDLGT------PIPL------STLGTVTVSVVGLEDYLP 3216

Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLAL 2871
             F   E++  V  DA  G+E++Q+  L
Sbjct: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATL 3243



 Score =  680 bits (1755), Expect = 0.0
 Identities = 743/2725 (27%), Positives = 1200/2725 (44%), Gaps = 230/2725 (8%)

Query: 42   ISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            + E++P G+ V  + AQD D+     L + +        F++  DTG++    PLDRE  
Sbjct: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFA 1100

Query: 99   SEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
            S + +     D   V      +V I+V D NDN P      +   I E+ PVGT +  ++
Sbjct: 1101 SYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160

Query: 156  ATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
            A DPD  + G + ++    +   FF I    G+++  ++LD E    + L V   D  + 
Sbjct: 1161 AWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEP 1220

Query: 214  RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH-SP--PGTTVRIITAIDQDKGRPRG 270
               ST + + + I DV D  PIF +  ++  + E  SP  PG   R++ A D D+G    
Sbjct: 1221 SLKST-SRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLV-ASDLDEGLNGR 1278

Query: 271  IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
            + Y+I   +  + F++D ++GV++ +         Y+   ILT+K T+    + P  A+V
Sbjct: 1279 VTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGE--YN---ILTIKATD--SGQPPLSASV 1330

Query: 331  TTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVY 389
                  +      + P  F+ + YS  + E   V       + V+  +   GL   F + 
Sbjct: 1331 RLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNH----MVGVISVEGRPGL-FWFNIS 1385

Query: 390  LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKIT 449
              G+    F I  T+        I +A PLD  T  R +++L    +        +V I 
Sbjct: 1386 -GGDKDMDFDIEKTTGS------IVIARPLD--TRRRSNYNLTVEVTDGSRTIATQVHIF 1436

Query: 450  LI-NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
            +I N N +RP F +  Y + + ++   G  +L V A D D G     +   S DP     
Sbjct: 1437 MIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASL 1496

Query: 506  FSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGR----VRINVLDVNDNVPT 560
            F LD  +G+++ + +LD      + TLT++ RD   E    R    V I+V D N + P 
Sbjct: 1497 FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ--EIPIKRNFVWVTIHVEDGNLHPPR 1554

Query: 561  FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
            F +  Y  ++ +     T+L+++RA D D   N ++ YS++  ++ G +F+I+     G+
Sbjct: 1555 FTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEG-FFNINAL--LGI 1611

Query: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
            I++++ LD  Q ++    LTV A D G+P  +    V I V+  + + P FSK  YFV +
Sbjct: 1612 ITLAQKLD--QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669

Query: 681  VENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLDRE 737
             E+I  G+ +L ++A             + Y L EG+    F +N+ SG I+T   LD E
Sbjct: 1670 PESIPVGSPILLVSAMS--------PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721

Query: 738  TKSEYILIVRAVDGGVGHNQKTGIATVNIT--LLDINDNHPTWKDAPYYINLVEMTP--- 792
              S Y L +R      G N       V +   ++D NDN P +  + +   + E  P   
Sbjct: 1722 KISSYQLKIR------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775

Query: 793  ----PDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPD 846
                 +++   + A D D   N  LVY I  P   KF+ ++ + G +     M       
Sbjct: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEM------- 1828

Query: 847  PHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
             +E+    +  V V D G P L A   A V +++ D+ND+ P F    +   ++  I  G
Sbjct: 1829 DYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPG 1888

Query: 907  VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLR 964
            + +  V A D D  +N    Y +  G       I+  +G   V+    L   R    +L 
Sbjct: 1889 MELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLT 1940

Query: 965  VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
            + ASD        T+ + I +  V D++  F   VY  +V E++     +V L    N  
Sbjct: 1941 IRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNH- 1996

Query: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTV-VGLDRETTAAYMLILEAIDNGPVGKRHT 1083
             LN  LSYF+  G     F +     V++T  V  DRE    + L +E  DN     +  
Sbjct: 1997 -LNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQRV 2051

Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILH 1143
                V V++ DVNDN P F    Y   + +    G  + Q+ ATD D G  G V Y    
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111

Query: 1144 GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
                  FRI    G +    +P D +  + + L V A +     ++S   V+V V   N 
Sbjct: 2112 DY--TYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NK 2166

Query: 1204 EAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-FEIDEST 1262
              P+F Q  Y ++ + E   + T ++  QA    S +G  + Y I+       F  D  T
Sbjct: 2167 SNPLF-QSPYYKVRVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKT 2222

Query: 1263 GLIITVNYLDYETKTSYMMNVSATDQA-PPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
            G++     LDYE+KT ++  V ATD A   F++    V +  +N  D    FS   Y  +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVN--DNPPTFSQLVYTTS 2280

Query: 1322 ILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI-TVQGLVD 1378
            I E L   T ++++ A   D+     ++Y+     S  +K  F+I+  TG + TVQ L  
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK-FFQINGSTGEMSTVQELDY 2339

Query: 1379 REKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV 1438
              +  F+      D G P +     V + V D NDN P F      A ++ E    G  V
Sbjct: 2340 EAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEA-NVSELATCGHLV 2398

Query: 1439 ATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1498
              V+A DPD+    ++ + + SGN    F I   N S G + +     +     Y L+V 
Sbjct: 2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFI---NSSSGIISMFNLCKKHLDSSYNLRVG 2455

Query: 1499 ASD---RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
            ASD   R T P      + +   + N   P  +    Y   + EN   GT V+ + A D+
Sbjct: 2456 ASDGVFRATVP------VYINTTNANKYSPEFQQHL-YEAELAENAMVGTKVIDLLAIDK 2508

Query: 1556 DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS 1615
            D G    + Y I        F ++  +G+IAT     DRE  +   +   V         
Sbjct: 2509 DSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKL-DRENSTERVIAIKVMARDGGGRV 2566

Query: 1616 ATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675
            A   V + + DENDN P F+   Y V +       ++ +I + A D DEG N  VTY++ 
Sbjct: 2567 AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSK-DSPVIQVLAYDADEGQNADVTYSVN 2625

Query: 1676 AGNIV-NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNV 1734
              ++V +   I+   GV+     L   + +      + A D  P       S   V + V
Sbjct: 2626 PEDLVKDVIEINPVTGVVKVKDSL-VGLENQTLDFFIKAQDGGP---PHWNSLVPVRLQV 2681

Query: 1735 NDINDNVPTFPRD---YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDG----- 1786
                 ++P F      +  P ++ EG     V    A D        V YS++ G     
Sbjct: 2682 VPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD-------PVIYSLVRGTTPES 2734

Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
            +  G F + P  GV++VRK   +D E+   Y + + A       + S + V I+V D+ND
Sbjct: 2735 NKDGVFSLDPDTGVIKVRKP--MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792

Query: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITA---GNRERAFFINA 1903
            N PV    P    ++EN PV + V  V A D D+G + ++++ ++A    N    F I++
Sbjct: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDS 2852

Query: 1904 TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
             +G +T  + LD E    Y   +   D+ +  +++ +   L+ + ++DENDN P F    
Sbjct: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQA--LVQVSITDENDNAPRFASEE 2910

Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDAD--QDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2021
            Y+  V+ENS  G  +  L      LDAD  +    V  Y   G   G F I+       +
Sbjct: 2911 YRGSVVENSEPGELVATLK----TLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRI 2966

Query: 2022 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLEN 2081
             S   +DRE  +  +L +   A D G   ++  + I +LD NDN P  S    T  + E+
Sbjct: 2967 SSRKTLDREHTAKYLLRVT--ASD-GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHED 3023

Query: 2082 CPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYR 2141
              PG  +L+V+ATD D+  N ++ Y +       F +   TG +    A +DRE ++ + 
Sbjct: 3024 VFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTA-LDRERKDVFN 3082

Query: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201
            L   ATD G    S  A +T+ ++D+ND+ P F      V+V ++    T +A + A D 
Sbjct: 3083 LVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDP 3140

Query: 2202 D--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
            D   N ++ Y             L  + E  F+++  TG + ++ P+     A  E+T+ 
Sbjct: 3141 DQGANAQVVYS------------LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188

Query: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
              D  + +P  ++      +TV+V+ + D  P F     T +  ++ E A PGT ++ +A
Sbjct: 3189 ASDLGTPIPLSTLGT----VTVSVVGLEDYLPVFLN---TEHSVQVPEDAPPGTEVLQLA 3241

Query: 2320 AVD-PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNG 2378
             +  P     G   Y ++     G  +L D+  G +  N ++D+E       ++  S   
Sbjct: 3242 TLTRPGAEKTG---YRVVSGNEQGRFRL-DARTGILYVNASLDFETSPKYFLSIECSRKS 3297

Query: 2379 SPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIE 2438
            S   +    V + I D+N++ P F Q  Y   V E+  VG +ILTV+ATD D    + I 
Sbjct: 3298 SSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDIT 3357

Query: 2439 YSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVV 2496
            YSL  G+    F I+P  G++ V  +LDRE+   Y L   A D+              + 
Sbjct: 3358 YSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDS----GQPPLHEDTDIA 3413

Query: 2497 IQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL---EGPGV 2553
            IQV DVND  P+F +  +ST+V EN P G+ V+ ++ +D D   NG   YS    +G   
Sbjct: 3414 IQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGP-PYSFRITKGNNG 3472

Query: 2554 EAFHVDMDSGLVTTQ-RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
             AF V  D  LVT +    ++ E + L + A+D G PPL   T + V V + +   P  +
Sbjct: 3473 SAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSAL 3532

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL--KTAGNRDWEFFIIDPIS 2670
              P    + + E+      V +++ATD+D      + YS    +T G      F +    
Sbjct: 3533 --PLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRH----FSVGAPD 3584

Query: 2671 GLIQTAQRLDRESQAVYSLILVASD 2695
            G I  AQ L R     YS  +  SD
Sbjct: 3585 GKIIAAQGLPR---GHYSFNVTVSD 3606



 Score =  607 bits (1565), Expect = e-173
 Identities = 561/1939 (28%), Positives = 870/1939 (44%), Gaps = 144/1939 (7%)

Query: 39   YLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            ++ I E  PVGS +  LL   M    + + +        F++   +G++  ++ LD E  
Sbjct: 1666 FVEIPESIPVGSPI--LLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI 1723

Query: 99   SEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI------ 151
            S + ++   S+  G  T   V + + D NDNAP F    +  +I E  P+ + I      
Sbjct: 1724 SSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN 1783

Query: 152  -FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
             F+++A+D D  A   ++Y    P   +FF ID + G +T++ E+DYE+  ++Q  V   
Sbjct: 1784 PFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVH 1843

Query: 209  DQDKT-----RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
            DQ        RP    A + I + DV D  P F    Y   I     PG  + ++ A D+
Sbjct: 1844 DQGSPVLFAPRP----AQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899

Query: 264  DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
            D      + Y+I +GN +    +  ++G +++       NP +     L+ K T    D 
Sbjct: 1900 DSE----VNYSIKTGNADEAVTIHPVTGSISVL------NPAFLG---LSRKLTIRASDG 1946

Query: 324  TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
               D   T    I +  + D + +F+   Y  A+ E  Q   AL     V+   +   LN
Sbjct: 1947 LYQD---TALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL-----VILGAQGNHLN 1998

Query: 384  SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
                 +L+ G +  H + S   +Q +        +  D E  D ++  +   ++  P  V
Sbjct: 1999 DTLSYFLLNGTDMFHMVQSAGVLQTRG-------VAFDREQQDTHELAVEVRDNRTPQRV 2051

Query: 442  GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
                V++++ + NDN P F    Y   + +    G  +  V ATD D GT G V+Y F++
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111

Query: 502  DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
            D   F +D   G I L    DY+ + ++ L +IARDGG         + V   N + P F
Sbjct: 2112 DYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLF 2171

Query: 562  QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS---AFGSYFDISLYEGY 618
            Q   Y   + EN   +T    +  T   SP   ++ Y+IV       F + F        
Sbjct: 2172 QSPYYKVRVPEN---ITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKT------ 2222

Query: 619  GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF--DENDNPPTFSKPAY 676
            GV++V+ PLDYE  +  +   TV A D     L S    T+EV   D NDNPPTFS+  Y
Sbjct: 2223 GVLTVTGPLDYESKTKHV--FTVRATDTA---LGSFSEATVEVLVEDVNDNPPTFSQLVY 2277

Query: 677  FVSVVENIMAGATVLFLNATDLD--RSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
              S+ E + A   V+ L A+D D  R+R+   + +    + S  F+IN  +GE++T   L
Sbjct: 2278 TTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQEL 2337

Query: 735  DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
            D E +  + + VRA+D   G    TG   V + + DINDN P ++   Y  N+ E+    
Sbjct: 2338 DYEAQQHFHVKVRAMD--KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395

Query: 795  SDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
              V  V A+DPD  +   L Y I   N  + + +NS++G       ++   N      + 
Sbjct: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG-------IISMFNLCKKHLDS 2448

Query: 853  MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
               + V  +D      +AT    V++N  + N   P FQ   + AE+ E    G  +  +
Sbjct: 2449 SYNLRVGASD---GVFRAT--VPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL 2503

Query: 913  VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE--YQLRVVASDA 970
            +AID D G  G + Y +   +    F IN  +G + T  +LDRE   E    ++V+A D 
Sbjct: 2504 LAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDG 2562

Query: 971  GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
            G   + +  T+ I + D ND  P F  + Y VS+  +V ++  V+ +   D D G NA++
Sbjct: 2563 G--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADV 2620

Query: 1031 SYFITGGN-VDGKFSVGYRDAVVR---TVVGLDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
            +Y +   + V     +     VV+   ++VGL+ +T   +   ++A D GP         
Sbjct: 2621 TYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFF---IKAQDGGP--PHWNSLV 2675

Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-- 1144
             V + V+    + P F +  Y  S PED+PEG  I  +KA  A +     V Y ++ G  
Sbjct: 2676 PVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTT 2731

Query: 1145 ---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
               N    F +    G++ +  +P+D E    + + V A+      + S V V + V D+
Sbjct: 2732 PESNKDGVFSLDPDTGVI-KVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDV 2790

Query: 1202 NDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL----SGAEGKFE 1257
            ND  PVF    Y  + L E   +GTSVI V A D+D+G  G V+YR+     S     F 
Sbjct: 2791 NDNRPVFEADPYKAV-LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFA 2849

Query: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNA 1316
            ID  +G I T+  LD ET  +Y  +V A D            V +++ +E D A +F++ 
Sbjct: 2850 IDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASE 2909

Query: 1317 SYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV--ITVQ 1374
             Y  +++EN   G  +  ++    D   Q        T       F I  +     I+ +
Sbjct: 2910 EYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSR 2969

Query: 1375 GLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPV 1434
              +DRE    Y L V A DG  K  ++V V I VLD NDNSP+      +   + ED   
Sbjct: 2970 KTLDREHTAKYLLRVTASDG--KFQASVTVEIFVLDVNDNSPQCSQLLYTG-KVHEDVFP 3026

Query: 1435 GQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYI 1494
            G  +  V A D D  +N Q+ +SL      GA E    +   GE+     LDRE  D + 
Sbjct: 3027 GHFILKVSATDLDTDTNAQITYSLHG---PGAHEF-KLDPHTGELTTLTALDRERKDVFN 3082

Query: 1495 LQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATD 1554
            L   A+D G    + D  L V   D+NDN P    P    V+V +N    T V  V A D
Sbjct: 3083 LVAKATDGGGRSCQADITLHVE--DVNDNAPRF-FPSHCAVAVFDNTTVKTPVAVVFARD 3139

Query: 1555 RDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP-T 1613
             D G N+ + Y + + + +  F +D  +G I     P     Q+   L     D GTP  
Sbjct: 3140 PDQGANAQVVYSLPD-SAEGHFSIDATTGVIRLE-KPLQVRPQAPLELTVRASDLGTPIP 3197

Query: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
            LS    V V++V   D  P+F    + V   + P+        +Q   L         Y 
Sbjct: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSV---QVPEDAPPGTEVLQLATLTRPGAEKTGYR 3254

Query: 1674 IVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVN 1733
            +V+GN    FR+D   G++     LD+E S  +Y L +  + +    S  L+  TTV+VN
Sbjct: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETS-PKYFLSIECSRKS---SSSLSDVTTVMVN 3310

Query: 1734 VNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
            + D+N++ P FP+D      +     G  + T  A D D   N  + YS++ G+ LG F 
Sbjct: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370

Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
            I P +G L+V K   LDRE  + Y+L + A D G PPL     + I+V D+NDN P    
Sbjct: 3371 IHPKKGELQVAK--ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQ 3428

Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAFFINATTGIVTVNR 1912
            L  + T+ ENSP+ S V  ++ SD DS  N    +F IT GN   AF +     +VT   
Sbjct: 3429 LNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA-E 3487

Query: 1913 PLDRERIPEYKLTISVKDN 1931
             L R     Y+L I   D+
Sbjct: 3488 GLSRRAQEWYQLQIQASDS 3506



 Score =  305 bits (782), Expect = 4e-82
 Identities = 331/1204 (27%), Positives = 516/1204 (42%), Gaps = 83/1204 (6%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
            P F  H ++  L  +E+  VG+ V  LLA D D+ P   + + +  + AS  F++ P+  
Sbjct: 2479 PEFQQHLYEAEL--AENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQ 2536

Query: 86   VVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
            +  L Q LDRE  +E  +   V    G   V    V I + D NDN P F    Y+V I 
Sbjct: 2537 IATL-QKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQ 2595

Query: 143  ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQ 199
             N    +P+  V A D D G    V YS  P         I+   G+V V   L     Q
Sbjct: 2596 SNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ 2655

Query: 200  AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
                 + A D       ++L  + + +   +   P F    Y+ +  E  P G+ + I+ 
Sbjct: 2656 TLDFFIKAQDGGPPH-WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVK 2714

Query: 260  AID-QDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGT 317
            A+  QD      +  T    N + +F+LD  +GV+ +   +D E+  LY     + V   
Sbjct: 2715 AVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQ----IDVMAH 2770

Query: 318  ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
             L +    +D     + NI V D+NDN P F +  Y   +TE   VG ++ + +  +DKD
Sbjct: 2771 CLQN----TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV-IQVTAIDKD 2825

Query: 378  ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-- 435
                    + +     ++ H + +  S  G     I     LD ET   Y F + A +  
Sbjct: 2826 TGRDGQVSYRLSADPGSNVHELFAIDSESGW----ITTLQELDCETCQTYHFHVVAYDHG 2881

Query: 436  SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE- 494
                    A V++++ +ENDN P F+   Y  S+ EN   G  V T+   D D       
Sbjct: 2882 QTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQ 2941

Query: 495  -VSYFFSDDP-DRFSLDK--DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
               Y    DP  +F + +  D   I     LD E   ++ L + A DG  + +   V I 
Sbjct: 2942 VTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASV-TVEIF 3000

Query: 551  VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
            VLDVNDN P   +  Y G + E+      ++++ ATD D+  N QITYS+    A     
Sbjct: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAH---- 3056

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
            +  L    G ++    LD E+    +  L   A D G     + +  T+ V D NDN P 
Sbjct: 3057 EFKLDPHTGELTTLTALDRER--KDVFNLVAKATDGGGRSCQADI--TLHVEDVNDNAPR 3112

Query: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEI 728
            F      V+V +N      V  + A D D+        ++YSL  S +  F I+A +G I
Sbjct: 3113 FFPSHCAVAVFDNTTVKTPVAVVFARDPDQG---ANAQVVYSLPDSAEGHFSIDATTGVI 3169

Query: 729  TTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLV 788
                 L    ++   L VRA D G      T + TV ++++ + D  P + +  + + + 
Sbjct: 3170 RLEKPLQVRPQAPLELTVRASDLGTPIPLST-LGTVTVSVVGLEDYLPVFLNTEHSVQVP 3228

Query: 789  EMTPPDSDVTTVVAVD-PDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
            E  PP ++V  +  +  P   + G  V S     +F  L++ TG I   +A LD E    
Sbjct: 3229 EDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRF-RLDARTG-ILYVNASLDFETSPK 3286

Query: 848  H--EAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
            +    E  RK   S++D            TV VN+ D+N++ P F   P+   VLE    
Sbjct: 3287 YFLSIECSRKSSSSLSDV----------TTVMVNITDVNEHRPQFPQDPYSTRVLENALV 3336

Query: 906  GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
            G  I  V A D D  LN  ++Y +  G     F I+   G +     LDRE+ + Y L++
Sbjct: 3337 GDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKL 3396

Query: 966  VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG 1025
             A+D+G P     + + I V DVND  P FF   Y+ +V E+ P   +V+ L  +D D  
Sbjct: 3397 RATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSP 3456

Query: 1026 LNA-ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG--PVGKRH 1082
             N    S+ IT GN    F V   D  + T  GL R     Y L ++A D+G  P+    
Sbjct: 3457 ENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL---- 3511

Query: 1083 TGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
            +   +V V V + +   P  L      +V ED  +G  + ++ ATD D  +   + Y + 
Sbjct: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD--TLTYSLA 3569

Query: 1143 HGNH-GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
                 G +F +   +G ++   + L R   S +V + +      G   ++  V VYV  +
Sbjct: 3570 EEETLGRHFSVGAPDGKII-AAQGLPRGHYSFNVTVSD------GTFTTTAGVHVYVWHV 3622

Query: 1202 NDEA 1205
              EA
Sbjct: 3623 GQEA 3626



 Score =  109 bits (272), Expect = 5e-23
 Identities = 141/586 (24%), Positives = 237/586 (40%), Gaps = 78/586 (13%)

Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
            V + I+D ND  P+F  PSY+  + ED+P+ + I  VTATDAD G  A   Y+       
Sbjct: 134  VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM 193

Query: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
            FAI+PT+G + V   L+   +  + L  LA D    ++      S+  ++  ++     P
Sbjct: 194  FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE-----P 248

Query: 2508 QFSKPQFSTSVYENEPA---GTSVITMMATDQDEGPNGELTYSLEG-PG-----VEAFHV 2558
               KP    SV    P    GT+  T++      G   E    + G PG     ++++  
Sbjct: 249  ALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYAR 308

Query: 2559 DMDSGLVTTQ--RPLQSYEKFSLTVVATDGGEPPLW----GTTMLLVEVIDVNDNRPVFV 2612
              +  LV+ +    ++    F+L++ A  G  P  +    G  +   ++  +   + V+ 
Sbjct: 309  SNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYR 368

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
                   + + E  P  S V  V  T     L   ++ S            F ++  +GL
Sbjct: 369  -------VQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG-------FKLNARTGL 414

Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
            I T + +D   +A Y L +  S      P +    + + + D +++ PLF R        
Sbjct: 415  ITTTKLMDFHDRAHYQLHIRTS------PGQASTVVVIDIVDCNNHAPLFNRSSYDG--- 465

Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDL 2791
               T+ E+ P GT V  VT A D D G N  V Y IA G +   F + P  G +   + +
Sbjct: 466  ---TLDENIPPGTSVLAVT-ATDRDHGENGYVTYSIA-GPKALPFSIDPYLGIISTSKPM 520

Query: 2792 DRE-REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850
            D E  + I++F V+AS    W  P      + +   L          ++ND  P F +  
Sbjct: 521  DYELMKRIYTFRVRASD---WGSPFRREKEVSIFLQL---------RNLNDNQPMFEEVN 568

Query: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSM 2910
             T  +  D  VG  ++ + A+D D   N         + Y     N+ E     F +   
Sbjct: 569  CTGSIRQDWPVGKSIMTMSAIDVDELQN---------LKYEIVSGNELE----YFDLNHF 615

Query: 2911 DGIL---RTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRD 2953
             G++   R F    A  P  + + I A D   +     + I +++D
Sbjct: 616  SGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKD 661


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score =  738 bits (1904), Expect = 0.0
 Identities = 690/2424 (28%), Positives = 1094/2424 (45%), Gaps = 211/2424 (8%)

Query: 444  AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SD 501
            A V++ L + NDN P+F+   Y  S+ +    GT ++ VLATD D+G +G V+Y     +
Sbjct: 161  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 220

Query: 502  DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
                F++D  TGL       + E++     +        +E    + +  L +  +    
Sbjct: 221  VSSLFTIDSTTGLYSP----EVEILSAVNFS------ADKEVMNSLEM-FLPLLRHFKKV 269

Query: 562  QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF-DISLYEGYGV 620
            ++D    A ++ E S    +R +          Q   +     A   Y  +++   G G+
Sbjct: 270  ERDEEA-AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGI 328

Query: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
            I ++ PL +  + +  + L V A D G         VTI +F     P  F +P Y   V
Sbjct: 329  IYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386

Query: 681  VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDRE 737
             E++   + +  + A +   S     E I Y +       +F I+ R G I T   LD E
Sbjct: 387  YEDVPEDSPIGTVKAREPLNS----SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE 442

Query: 738  TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797
            T+   +L V+A  G       T    VNIT++D+NDNHP +      I + + TPP + +
Sbjct: 443  TQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL 499

Query: 798  TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKI 856
                A D D G NG + YSI  P    ++++   G +    ++   E     + EL   +
Sbjct: 500  YLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE-----QRELT--L 552

Query: 857  VVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVVA 914
             +   D G  P  A    TV   +++  ++ P  TF++L +  EV E +     + Q  A
Sbjct: 553  TLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 609

Query: 915  IDLD-EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDAG 971
              L  +     + Y +   +    F I   +G +    + D E    Y  RV A   + G
Sbjct: 610  HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 669

Query: 972  TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
                 ST T+ + V D ND +PTF   V  + V E    +  +  +   D D G N +L 
Sbjct: 670  FLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 728

Query: 1032 YFITGGNVDGKFS--------------VGYRDA-------------------VVRTV--- 1055
            YF+     DGKF               + + D                    V++++   
Sbjct: 729  YFLLS---DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCE 785

Query: 1056 ---------VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
                     V LDRE    + + +   D G   +    T  V+V+V D+NDNRP F Q  
Sbjct: 786  LGEGELINWVALDREHRGHHEMTVLVTDRGSPPRN--ATMAVYVSVTDINDNRPFFPQCL 843

Query: 1107 YEASVPEDIPEGHSILQLKAT----DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
                +   + EG  +  L  T    D DEG    V Y +   +  ++F+I  +NG + R 
Sbjct: 844  PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI-RT 902

Query: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETA 1222
               L  +   S+ + V A +  + P++    V + V  ++    + +Q     L + E  
Sbjct: 903  TTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQN-IRHLIIPENL 961

Query: 1223 GIGTSVIVVQATDR-DSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYM 1280
                 + +++++D       G +++ I++   +G FEID STG +     LDYET + Y+
Sbjct: 962  KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYL 1021

Query: 1281 MNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339
              V  TD +   +      + I + ++ D +  F +     ++ EN+ +GT +V V    
Sbjct: 1022 FRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGT-LVYVFNAK 1080

Query: 1340 IDNLNQITYRFNAYTSTQAKAL--FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK 1397
             D+ + +  R   Y  +       F I    G +     +DRE      LTV A D    
Sbjct: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140

Query: 1398 VDS----TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
            V      ++   I +LD ND++P F   S     + ED  VG  V  + A DPD G NG+
Sbjct: 1141 VTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGK 1198

Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
            V +S+ SGN    F +   ++S G +    PLD E    +IL V+A D GTP       L
Sbjct: 1199 VTYSILSGNENMTFML---DESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTL 1255

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
             VT+LD+ND  PV +    Y  SV EN   G  V +V A DRD G+NS L + I  G   
Sbjct: 1256 TVTVLDVNDEAPVFKQHL-YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASF 1314

Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
              F ++  +GE+ T     DRE Q  + L   V D G P+LS+TT +  T+ DEND+AP 
Sbjct: 1315 ELFEINSDTGEVVTTTIL-DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPE 1373

Query: 1634 FQQPHY--EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV 1691
            F    Y  EVL ++ P+ + T L    A D+D G N  V Y I+ GN    F I+   G 
Sbjct: 1374 FIVSSYDIEVLENQEPEVVYTVL----ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGE 1429

Query: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751
            ++  + LD E     +TL++  +D   +     +S   + V V D ND+ P+FP  Y   
Sbjct: 1430 LSTTRALDRE-QISNFTLVILCSD---LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485

Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
                + + G  V    A D+D G NGQ EY + D +  G F I P+ G L+      LDR
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNT--LDR 1542

Query: 1812 ETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
            E  + +  +  ARD  +    S+T+++ + V D+NDNDPVL   P ++ +S  SP +   
Sbjct: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602

Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
              V A D D G N  + F+      +  F I+  TG +   +    E  P + L + V D
Sbjct: 1603 VIVRADDLDLGPNGTVVFSFA--ETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTD 1659

Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
                   AR    LL+I +  E D    F+   Y+  V EN  AGT +  +     A D+
Sbjct: 1660 QGIP---ARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKA--FAPDS 1713

Query: 1991 DQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN 2050
             QD      +   G + G+  + S +G +TV+    +D E  +   ++L++LAE  G   
Sbjct: 1714 IQDSMKYSIFS--GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNE--VQLIVLAESSGH-R 1768

Query: 2051 STAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA 2110
            +   + + I D+NDN P F  +     + E+      V+QV ATD DSGLNG + Y I +
Sbjct: 1769 AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828

Query: 2111 GAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
            G Q+  F I  ++GVI    A +D E   SY L V ATD+G   LS T ++ + + DIND
Sbjct: 1829 GNQEEAFQIDALSGVITT-KAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIND 1887

Query: 2170 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2229
            + P FL P + V + E + PG ++ +++  D DLN    +      AK+       N   
Sbjct: 1888 NAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF----AKES------NPGT 1936

Query: 2230 AFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
             FA++ NTG V++   ++ E +  YE+ + + D        SV      L V VLDVNDN
Sbjct: 1937 KFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--------SVHYTEGALVVRVLDVNDN 1988

Query: 2290 TPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
             P F      +Y   + E    G +++ ++A D +   N  ++Y +L       +  ++ 
Sbjct: 1989 PPVFSQ---DFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNG 2043

Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
            +   +     +D   +    F V ASD G+P   A   V + I D+N+  P F   SY  
Sbjct: 2044 TIFTISPVLLLD--TISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101

Query: 2410 AVFEDVPVGTIILTVTATDAD-SGNFALIEYSLGDGESKFAINPTT------------GD 2456
            ++ ED  VG+ ++T +  D D +     +EYS+  G S+   +  T            G 
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161

Query: 2457 IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
            + +L SLDRE    + L  LA D+     S+    +  + IQVLDVND  P FS   + T
Sbjct: 2162 LVLLHSLDREASASHELVILASDSGCPPLSS----TAVISIQVLDVNDNPPNFSSLSYHT 2217

Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QS 2573
             V E+ P G+ +  + A D+D G + E+ Y++  G     F+++ ++G++   +PL  + 
Sbjct: 2218 HVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK 2277

Query: 2574 YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2633
              KF+LTV A+D  E   +   ++ V V+D ND+ P F+      I  + E +P+ S + 
Sbjct: 2278 MTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI--VPENLPISSTIC 2334

Query: 2634 EVYATDKDEGLNGAVRYS-----FLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYS 2688
             + A D D G  G + YS     FL    + D + F+IDP++G I   Q LD E+   Y 
Sbjct: 2335 SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394

Query: 2689 LILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
            L + A D G          + V +E ID+ EP+F +      QY   T+PE +    L+G
Sbjct: 2395 LTVQAKDKGDAT---ASLVVWVDIEGIDEFEPIFTQ-----DQY-FFTLPEKNKDRQLIG 2445

Query: 2749 NVTGAVDADEGPNAIVYYFIAAGN 2772
             V  A DAD G + ++ Y +   +
Sbjct: 2446 RVE-ASDADAGIDGVILYSLGTSS 2468



 Score =  650 bits (1678), Expect = 0.0
 Identities = 613/2169 (28%), Positives = 986/2169 (45%), Gaps = 190/2169 (8%)

Query: 41   LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            L+ ED P  S +  + A++  N  +P+ + +S  +    F++ P  G +  R+PLD ET+
Sbjct: 385  LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 444

Query: 99   SE--FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
                 TV+  +       + +VNI V DVNDN P F      +RI + TP GT +++  A
Sbjct: 445  PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504

Query: 157  TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
             D D G  G + YS   P    FAID A G++ +   L     +   LT+ A DQ    P
Sbjct: 505  EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 563

Query: 216  LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
             + L  L ++I + ++  P   F +L Y   + E   P      +T + Q +  P G   
Sbjct: 564  QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 616

Query: 271  ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGTELNDDRTP 325
                + Y++     +++F +   +G + L    D E+   Y+      +          P
Sbjct: 617  AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 666

Query: 326  SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
             D     V+TT  + V D NDN+P F      + + E + V   +   I  +D D   G 
Sbjct: 667  EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 723

Query: 383  NSMFEVYLVGNNSHH----------------------------FIISPTSVQ-------- 406
            N     +L+ +                                F  S   +Q        
Sbjct: 724  NGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLF 783

Query: 407  ---GKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHVGYAKVKITLINENDNRPIFSQ 462
               G+ ++   VA  LD E    ++   L  +   P       V +++ + NDNRP F Q
Sbjct: 784  CELGEGELINWVA--LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 841

Query: 463  PL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS--DDPDRFSLDKDTGLIM 516
             L     ++ + E   V   V TV A D D G   EV+Y  S  D  D F +D + G I 
Sbjct: 842  CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIR 901

Query: 517  LIARLDYELIQRFTLTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENE 574
                L Y+    + +++IA D G     G+  V I V+ ++       ++     + EN 
Sbjct: 902  TTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENL 961

Query: 575  PSVTQLVRLRATDE-DSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
                 +  ++++D      N ++ +SIV+    G +F+I      G + +S+ LDYE  S
Sbjct: 962  KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG-HFEID--SSTGDLFLSKELDYETTS 1018

Query: 634  NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFL 693
            +  ++  +    + N  L+STV ++I+V D+ND+ P+F      +SV EN+  G  V   
Sbjct: 1019 H-YLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVF 1077

Query: 694  NATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749
            NA D D S  +    I Y +E    G+  F I+   G + T S LDRE+    IL V A 
Sbjct: 1078 NAKDDDGS--FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTAS 1135

Query: 750  DGGVG-HNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
            D  V   +++    T  I +LD+ND++PT+   P   ++ E     S V  + A DPD G
Sbjct: 1136 DQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEG 1194

Query: 809  ENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
             NG + YSI   N+   + L+ ++G + TT        P  +E +    + V   D G P
Sbjct: 1195 RNGKVTYSILSGNENMTFMLDESSGLLTTT-------CPLDYEMKTQHILTVLALDDGTP 1247

Query: 867  PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926
             L  +SS T+ V +LD+ND  P F+   + A V E    G  + +V A+D D G+N  + 
Sbjct: 1248 AL--SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305

Query: 927  YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 986
            + +  G     F INS +G VVTTT LDRE    + LRV+  D G P+ SST+T+   V 
Sbjct: 1306 FEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVE 1365

Query: 987  DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
            D ND  P F  + Y++ V E+   E  V  +  +D D G N  + Y I  GN D  F++ 
Sbjct: 1366 DENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTIN 1424

Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
                 + T   LDRE  + + L++   D G   +  +    + V VLD ND+ P F    
Sbjct: 1425 EMSGELSTTRALDREQISNFTLVILCSDLGDPPR--SSVIHLQVRVLDANDHSPSFPTLY 1482

Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
            Y++SV ED   G  +L L A D DEG  G+  Y  L       F I   +G L +    L
Sbjct: 1483 YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTL-KTSNTL 1540

Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSRLGLRETAGIG 1225
            DRE  S H     A +  +   RS+  +I VYV D+ND  PV  Q  +  + L   +   
Sbjct: 1541 DREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD-VFLSPESPTN 1599

Query: 1226 TSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYM---MN 1282
             + ++V+A D D G  G V +   +  +  F ID+ TG I           + Y    + 
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEI----QFQQNPSSEYFPIWLQ 1654

Query: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
            +  TDQ  P       + I +  E D  + FS+  Y+  + EN   GT IV V+A++ D+
Sbjct: 1655 LKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS 1713

Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQ--GLVDREKGDFYTLTVVADDGGPKVDS 1400
            + Q + +++ ++  +   +  + + +G +TV+    +D E  +   L V+A+  G +  +
Sbjct: 1714 I-QDSMKYSIFSGNE-DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHR--A 1769

Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
              KV + + DENDNSP F+  S    S+ E       V  V A D D+G NG + +S+ S
Sbjct: 1770 YCKVAVLIQDENDNSPCFE-QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828

Query: 1461 GNIAGAFEIVTTNDSIGEVFVARP-LDREELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
            GN   AF+I    D++  V   +  LD E    Y L V A+D+G P      +++V + D
Sbjct: 1829 GNQEEAFQI----DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884

Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMD 1579
            INDN P         V + E+   G  V  V   D D+    + S +  E N    F +D
Sbjct: 1885 INDNAPAFLP--SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS-FAKESNPGTKFAID 1941

Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY 1639
            + +G +       D E  + Y L+  + D    T  A   + V ++D NDN P+F Q  Y
Sbjct: 1942 QNTG-VVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLDVNDNPPVFSQDFY 1997

Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
            +V + E    +  S++T+ A DL+   N  ++Y I++ +    F ID   G I     + 
Sbjct: 1998 QVTVPES-IPVGYSVLTLSATDLESNEN--ISYRILSSS--KEFSIDPKNGTIFTISPVL 2052

Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
               +      +V A+D     +  L + T V + + D+N+  P F           +   
Sbjct: 2053 LLDTISTTQFLVEASDGG---NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109

Query: 1760 GPRVWTFLAHDRD-SGPNGQVEYSIMDGDPLGEFVIS--------PVEGVLRVRKDVELD 1810
            G  + TF   D D +  N  VEYSI+ G+    F +         P + V  +     LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169

Query: 1811 RETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
            RE  A + L I A D G PPLSST ++ I+VLD+NDN P   +L  +  + E++P+ S +
Sbjct: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI 2229

Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
              V A+D D+G +A + +NI +GN +  F++   TG++ + +PLD E++ ++ LT+   D
Sbjct: 2230 TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289

Query: 1931 NPENPRIARRDYDLLLIFLS--DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILAL 1988
                    ++ +   ++F+S  D+ND+ P F  S++   V EN P  + +  +N    AL
Sbjct: 2290 ------AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN----AL 2339

Query: 1989 DADQDIYAVVTYQL---------LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
            D D   Y  +TY +         +     LF I+  TG +  +   I+D E  +     L
Sbjct: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQ--ILDYENGNKYC--L 2395

Query: 2040 LLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG 2099
             + A+D G   ++  + + I   ++  P F+       L E       + +V A+D D+G
Sbjct: 2396 TVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAG 2455

Query: 2100 LNGELVYRI 2108
            ++G ++Y +
Sbjct: 2456 IDGVILYSL 2464



 Score =  629 bits (1622), Expect = e-179
 Identities = 685/2525 (27%), Positives = 1084/2525 (42%), Gaps = 260/2525 (10%)

Query: 482  VLATDNDAGTFGEVSYFFSDD------PDRFSLDKDTGLIMLIARLDYELIQR-FTLTII 534
            V A+D D+G +G + Y   D       P  F +D   G I +   +D E     + L + 
Sbjct: 79   VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138

Query: 535  ARDG------------GGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVR 582
            A+DG            GG      VR+++ DVNDN P F    YV ++ +     T+++ 
Sbjct: 139  AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198

Query: 583  LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
            + ATD+DS     + Y ++  +   S F I                    + GL    V 
Sbjct: 199  VLATDQDSGIYGTVAYELIPGNV-SSLFTIDS------------------TTGLYSPEVE 239

Query: 643  AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
             + A N   +  V  ++E+F        F K        E     +   F+         
Sbjct: 240  ILSAVNFSADKEVMNSLEMFLPLLRH--FKKVERDEEAAEKKFEASRGWFMRFKGRRHLH 297

Query: 703  EYGQESIIYSLEGSTQFRINAR------SGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
                +    S +G    R  A        G I  T  L     +   L+V A DGG    
Sbjct: 298  YLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGG---- 353

Query: 757  QKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPDLGENGTLV 814
              T +   ++T+        P   + P Y  LV E  P DS + TV A +P L  +  + 
Sbjct: 354  GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIF 412

Query: 815  YSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATS 872
            Y I   +    +S++   G IRT         P  HE +    +VV           A S
Sbjct: 413  YRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQLGSAPACS 462

Query: 873  SATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVG 932
            S  V + ++D+NDN P F        + +  P G ++Y   A D D G NGL+ Y +   
Sbjct: 463  STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 522

Query: 933  MPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
             P + F I+ + GV+     L      E  L + A D G   +++   LT+ V++  + +
Sbjct: 523  QPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHS 580

Query: 993  P--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLN---AELSYFITGGNVDGKFSVGY 1047
            P  TF   VY V VSE +    ++  L    + +G     + L Y +        F +  
Sbjct: 581  PSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRP 638

Query: 1048 RDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSY 1107
                +      D E+T  Y   + A        ++  T TV V V D NDN P FL    
Sbjct: 639  YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVL 697

Query: 1108 EASVPED-IPEGHSILQLKATDADEGEFGRVWYRILH-----------GNHGNNFRIHVS 1155
               V E  +P+G  I ++ A D D G+ G++ Y +L            G  G  + I  +
Sbjct: 698  FLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756

Query: 1156 NGL--------------------------LMRGPR----PLDRERNSSHVLIVEAYNHDL 1185
            +G                           L  G       LDRE    H + V   +   
Sbjct: 757  DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQ---QQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242
             P  +++ V V V DIND  P F Q    +   + + E   +   V  V A D D G+  
Sbjct: 817  PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 876

Query: 1243 LVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
             V Y + S  +   F+ID + G I T   L Y+ + SY M+V ATDQ  P  QG   V I
Sbjct: 877  EVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNI 936

Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK-- 1359
             ++         S       I ENL   T+I+ +   S D+L Q  Y    + S  A   
Sbjct: 937  QVIPLSKGRAIMSQNIRHLIIPENLK-PTKIMSL-IKSSDHLQQ-HYNGKLHFSIVADDK 993

Query: 1360 -ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSP 1416
               F+ID+ TG + +   +D E    Y   V+  D    +   STV + I V D+ND+SP
Sbjct: 994  DGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSP 1053

Query: 1417 RFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDS 1475
             F       +S+ E+ P+G  V    A D D    N ++ + + S N      ++  + S
Sbjct: 1054 SFQ-DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLI--HPS 1110

Query: 1476 IGEVFVARPLDREELDHYILQVVASDRG---TPPRKKDHILQVTILDIND-NPPVIESPF 1531
             G +     LDRE +   IL V ASD+    T  R +    Q+ ILD+ND NP  I  P 
Sbjct: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP- 1169

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
              N  V E+V  G+ V  + A D D G N  ++Y I  GN++M F +D  SG + T   P
Sbjct: 1170 --NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG-LLTTTCP 1226

Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
             D E ++ + L     D+GTP LS++  + VT++D ND AP+F+Q  YE  + E  +   
Sbjct: 1227 LDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP-G 1285

Query: 1652 TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIV 1711
              +  ++ALD D G N  + + I+ G     F I+   G +     LD EI       ++
Sbjct: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345

Query: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHD 1770
                  P LS    STTT+L  V D ND+ P F    Y+   EV E Q    V+T LA D
Sbjct: 1346 VRDGGFPSLS----STTTILCTVEDENDHAPEFIVSSYD--IEVLENQEPEVVYTVLASD 1399

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D+G N  VEY I+DG+    F I+ + G L   +   LDRE I+ + L I   D G PP
Sbjct: 1400 MDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR--ALDREQISNFTLVILCSDLGDPP 1457

Query: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
             SS + + +RVLD ND+ P    L    ++ E++ V + V  + A D D G N +  + +
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL 1517

Query: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
            T      AF I+  +G +  +  LDRE   ++  +   +D   + + +R    ++ ++++
Sbjct: 1518 T-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC--SIQGSRSTTVIIKVYVT 1574

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
            D NDN P+  ++ +   +   SP      ++     A D D      V +     QS +F
Sbjct: 1575 DVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR----ADDLDLGPNGTVVFSFAETQS-MF 1629

Query: 2011 DINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
             I+  TG +  +         + P  L+L +  + I    +T  LL+  ++  D + +FS
Sbjct: 1630 SIDKYTGEIQFQQN---PSSEYFPIWLQLKVTDQGIPARTTTG-LLVIHMEGEDVKISFS 1685

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTGVIRVGN 2129
                   + ENC  G S++ V A   DS +   + Y I +G +D  L +   +G + V  
Sbjct: 1686 HHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKE 1744

Query: 2130 AT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
               +D E +   +L V+A   G         V +LI D ND+ P F   I   SV ES  
Sbjct: 1745 PKFLDFEVRNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801

Query: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
                +  + A D D  LN  +EY I           L  NQE+AF ++  +G +  K+ +
Sbjct: 1802 YNAHVIQVFATDLDSGLNGLIEYSI-----------LSGNQEEAFQIDALSGVITTKAIL 1850

Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
            + EL ++Y + +   D    +P  S +     + V V D+NDN P F P         I 
Sbjct: 1851 DYELTSSYSLIVQATDKG--MPRLSNTTV---IKVQVTDINDNAPAFLPSEAV----EIT 1901

Query: 2307 EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVH 2366
            E + PG  +  V+  D D  LN    ++      PG     D + G V+  +T+D+EE+ 
Sbjct: 1902 EDSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959

Query: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
                 ++ SD+      A +   + ++D+NDN P+F Q  YQ  V E +PVG  +LT++A
Sbjct: 1960 EYELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016

Query: 2427 TDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSS---LDREKKDHYILTALAKDNPGD 2483
            TD +S     I Y +     +F+I+P  G I+ +S    LD      +++ A    NP  
Sbjct: 2017 TDLESNEN--ISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-- 2072

Query: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNG 2542
                R    V++ I+  D+N+  P+F+   ++ S+ E+   G++++T    D D    N 
Sbjct: 2073 --DLRALTLVEIGIE--DMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128

Query: 2543 ELTYSL-EGPGVEAFHVDM----------DSGLVTTQRPL--QSYEKFSLTVVATDGGEP 2589
             + YS+  G     FHV+             G +     L  ++     L ++A+D G P
Sbjct: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188

Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
            PL  T ++ ++V+DVNDN P F      T  H++E  PL S++  V A D+D G +  + 
Sbjct: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHT--HVKESTPLGSHITVVSANDRDTGSHAEII 2246

Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
            Y+ +  +GN    F++ +  +G++   + LD E    ++L + ASD  +   + +   + 
Sbjct: 2247 YNII--SGNEKGHFYL-EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK--HFSFAVVF 2301

Query: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
            V++ D +D+ P F+             VPE+ P  + + ++  A+D D GP   + Y I 
Sbjct: 2302 VSVLDDNDHAPQFMFSSFSC------IVPENLPISSTICSIN-ALDFDAGPYGELTYSIV 2354

Query: 2770 A--------GNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
            +          +   F + P  G +   + LD E    +   V+A               
Sbjct: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG----------- 2403

Query: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
             D  A L    V V +E I++  P FT+ +Y   +    K    + +V A DAD G + +
Sbjct: 2404 -DATASLV---VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGV 2459

Query: 2881 VFYSI 2885
            + YS+
Sbjct: 2460 ILYSL 2464



 Score =  629 bits (1621), Expect = e-179
 Identities = 664/2546 (26%), Positives = 1129/2546 (44%), Gaps = 262/2546 (10%)

Query: 258  ITAIDQDKGRPRGIGYTIVSG----NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
            +TA D D G    I Y++  G         F +D   G + ++  +DRE    ++  ++ 
Sbjct: 79   VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138

Query: 314  VKGTELNDDRTPSDATVTTTFNILVI------DINDNAPEFNSSEYSVAITELAQVGFAL 367
             K  +  + R    A V    +          D+NDN P FN S Y  +I++  Q G  +
Sbjct: 139  AKDGD--EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196

Query: 368  PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
               I V+  D++ G+       L+ GN S  F I  T+     ++ I  A+    +    
Sbjct: 197  ---INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVM 253

Query: 427  YDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATD 486
               ++F    +P    + KV      E D      +   +   +        +  +   D
Sbjct: 254  NSLEMF----LPLLRHFKKV------ERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQD 303

Query: 487  NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETT-- 544
              A   GE +  +  +  +   +   G+I L   L +      +L + A+DGGG      
Sbjct: 304  EAASADGEAAARYVANLAKILGE---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN 360

Query: 545  GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
              V I++         F++  Y   + E+ P  + +  ++A  E    +  I Y I S  
Sbjct: 361  ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGD 419

Query: 605  AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE 664
              G +   S++   G I   +PLD+E  +  ++ LTV A   G+ P  S+  V I V D 
Sbjct: 420  LGGKF---SIHPRLGTIRTRKPLDHE--TQPVVVLTVQAQ-LGSAPACSSTEVNITVMDV 473

Query: 665  NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRI 721
            NDN P F + +  + + +    G  +    A D    R+ G+  +I     S Q   F I
Sbjct: 474  NDNHPAFLRTSDEIRISQTTPPGTALYLARAED----RDSGRNGLIRYSIASPQPGVFAI 529

Query: 722  NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW--K 779
            +   G +     L    + E  L +RA D GV       + TV   +++  ++ P+W  +
Sbjct: 530  DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFE 586

Query: 780  DAPYYINLVEMTPPDSDVTTVVA--VDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
               Y + + E   P + +    A  + P    +  L YS++P   +  + +   TG I  
Sbjct: 587  HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYL 645

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
                 D E+   +      ++   + + G        S TV V + D NDN PTF +   
Sbjct: 646  RR-QFDYESTQTYNF----RVFAWIPEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVL 697

Query: 896  VAEVLEG-IPAGVSIYQVVAIDLDEGLNGLVSYRM--------------PVG-------- 932
              +V E  +P GV I ++ AID+D G NG + Y +              P G        
Sbjct: 698  FLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756

Query: 933  -----MPRMDFLINSSS---------------GVVVTTTELDRERIAEYQLRVVASDAGT 972
                     DF  +S                 G ++    LDRE    +++ V+ +D G+
Sbjct: 757  DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816

Query: 973  PTKSSTSTLTIHVLDVNDETPTFFPAVY-----NVSVSEDVPREFRVVWLNCTDNDVGLN 1027
            P +++T  + + V D+ND  P FFP        +V V E  P    V  +   D D G N
Sbjct: 817  PPRNATMAVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875

Query: 1028 AELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
            AE++Y ++  +    F +   +  +RT   L  +   +Y + + A D G    +  G A 
Sbjct: 876  AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ--GQAV 933

Query: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF-GRVWYRILHGNH 1146
            V + V+ ++  R I  Q+     +PE++     +  +K++D  +  + G++ + I+  + 
Sbjct: 934  VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDK 993

Query: 1147 GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PMRSSVRVIVYVEDINDEA 1205
              +F I  S G L    + LD E  S ++  V   +H     + S+V + + VED ND +
Sbjct: 994  DGHFEIDSSTGDLFLS-KELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052

Query: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK------FEID 1259
            P F Q +   + + E   IGT V V  A D    DG  +N RI    E        F I 
Sbjct: 1053 PSF-QDELIVISVEENVPIGTLVYVFNAKD---DDGSFLNSRIQYYIESHNPGTNPFLIH 1108

Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG---FCSVYITLLNELDEAVQFSNA 1316
             S G ++TV+ LD E+  + ++ V+A+DQA           +  I +L+  D    F + 
Sbjct: 1109 PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF 1168

Query: 1317 SYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
               A + E++ +G+ +  + A+  D     ++TY   +  S      F +D  +G++T  
Sbjct: 1169 P-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNENMTFMLDESSGLLTTT 1224

Query: 1375 GLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
              +D E    + LTV+A DDG P + S+  + +TVLD ND +P F      A S+ E+  
Sbjct: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA-SVKENQN 1283

Query: 1434 VGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHY 1493
             G+ V  V+A D D+G N ++ F +  G    +FE+   N   GEV     LDRE  + +
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPG---ASFELFEINSDTGEVVTTTILDREIQEVF 1340

Query: 1494 ILQVVASDRGTPPRKKDHILQVTILDINDNPP--VIESPFGYNVSVNENVGGGTAVVQVR 1551
             L+V+  D G P       +  T+ D ND+ P  ++ S   Y++ V EN      V  V 
Sbjct: 1341 TLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS---YDIEVLENQEP-EVVYTVL 1396

Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGT 1611
            A+D D G N  + Y+I +GN D  F ++ +SGE++T  A  DRE+ S + LV    D G 
Sbjct: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRAL-DREQISNFTLVILCSDLGD 1455

Query: 1612 PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT 1671
            P  S+  H+ V ++D ND++P F   +Y+  + E  + + T ++ + A+D DEG NG   
Sbjct: 1456 PPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAE-VGTVVLVLSAVDKDEGLNGQTE 1514

Query: 1672 YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVL 1731
            Y  +       F ID   G +  +  LD E +  ++T    A D C I   R T T  + 
Sbjct: 1515 Y-FLTDEASGAFTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARD-CSIQGSRST-TVIIK 1570

Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFL---AHDRDSGPNGQVEYSIMDGDP 1788
            V V D+NDN P   ++   PF+V      P   T +   A D D GPNG V +S  +   
Sbjct: 1571 VYVTDVNDNDPVLEQN---PFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS 1627

Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
            +  F I    G ++ +++   +   I    L +   D+G+P  ++T L+ I +    + +
Sbjct: 1628 M--FSIDKYTGEIQFQQNPSSEYFPIW---LQLKVTDQGIPARTTTGLLVIHM----EGE 1678

Query: 1849 PVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATT 1905
             V ++   ++    ++EN    + +  V A   DS     + ++I +GN +    + + +
Sbjct: 1679 DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS 1737

Query: 1906 GIVTVNRP--LDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
            G +TV  P  LD E   E +L +  + +        R Y  + + + DENDN P F +S 
Sbjct: 1738 GQLTVKEPKFLDFEVRNEVQLIVLAESS------GHRAYCKVAVLIQDENDNSPCFEQSI 1791

Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVR 2022
            YQA V E+      +      + A D D  +  ++ Y +L G Q   F I++ +GV+T +
Sbjct: 1792 YQASVSESQLYNAHVI----QVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847

Query: 2023 SGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLE 2080
            +  I+D E  S     L++ A D G+  L++T  + + + D NDN P F P+   V + E
Sbjct: 1848 A--ILDYELTSS--YSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902

Query: 2081 NCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTGVIRVGNATIDREEQE 2138
            +  PG  V  V+  D D  LN   ++    E+    +F I   TGV+ V   T+D EE  
Sbjct: 1903 DSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVV-VLVKTLDFEEMT 1959

Query: 2139 SYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITA 2198
             Y L +  +D       G  +V +L  D+ND+ P F      V+V ES   G  +  ++A
Sbjct: 1960 EYELLIQISD-SVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016

Query: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP-MNRELVATYEVT 2257
             D + N  + Y I+             +    F+++   G++   SP +  + ++T +  
Sbjct: 2017 TDLESNENISYRIL-------------SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFL 2063

Query: 2258 LSVIDNAS-DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            +   D  + DL  R++++    + + + D+N+  P+F    +  Y   + E A  G+TL+
Sbjct: 2064 VEASDGGNPDL--RALTL----VEIGIEDMNNYAPEFT---VKSYNLSLSEDALVGSTLV 2114

Query: 2317 AVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLEDS---------SAGKVIANRTVDYEEVH 2366
              + +D D    N  V Y+++         +E             G ++   ++D E   
Sbjct: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174

Query: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
                 + ASD+G PP ++   + ++++D+NDN P F   SY   V E  P+G+ I  V+A
Sbjct: 2175 SHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSA 2234

Query: 2427 TDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDV 2484
             D D+G+ A I Y++  G  K  F +   TG +Y++  LD EK   + LT  A D     
Sbjct: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD----- 2289

Query: 2485 ASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGEL 2544
            A  +  +   V + VLD ND  PQF    FS  V EN P  +++ ++ A D D GP GEL
Sbjct: 2290 AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349

Query: 2545 TYSLEGP---------GVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWG 2593
            TYS+  P           + F +D  +G +  ++ L  ++  K+ LTV A D G+     
Sbjct: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT--A 2407

Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL 2653
            + ++ V++  +++  P+F +  +     + E+   R  +  V A+D D G++G + YS  
Sbjct: 2408 SLVVWVDIEGIDEFEPIFTQ--DQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG 2465

Query: 2654 KTAGNRDWEFFIIDPISGLIQTAQRL 2679
             ++      FF ++  +G I   + L
Sbjct: 2466 TSS-----PFFSVNKTNGNIYLIRAL 2486



 Score =  615 bits (1585), Expect = e-175
 Identities = 653/2343 (27%), Positives = 1027/2343 (43%), Gaps = 243/2343 (10%)

Query: 71   GEEASRFFAVEPDT---GVVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGD 124
            GE A+R+ A        G+++L  PL     +  ++  S  D  G   VI   V I +  
Sbjct: 310  GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 369

Query: 125  VNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDS 182
                   F    Y+  + E+ P  +PI  V A +P L +   + Y          F+I  
Sbjct: 370  TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 428

Query: 183  ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
              G +   + LD+ET     LTV A  Q  + P  +   + I + DV D  P F+     
Sbjct: 429  RLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486

Query: 243  TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302
              I + +PPGT + +  A D+D GR   I Y+I S     +FA+D   GVL LNG L   
Sbjct: 487  IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 545

Query: 303  NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE--FNSSEYSVAITEL 360
                     LT++  +      P  A +  T   +VI+  +++P   F    Y V ++E 
Sbjct: 546  E---QRELTLTLRAEDQGVH--PQAALLVLT---VVIEKREHSPSWTFEHLVYQVEVSES 597

Query: 361  AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR-----IRV 415
                   P+   +  +   LG            +   + + P+       IR     I +
Sbjct: 598  LS-----PMTQMLQTQAHPLGPQR-------AASPLRYSLEPSVDSAMFGIRPYTGWIYL 645

Query: 416  AIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLI----NENDNRPIFSQPLYNISLYE 471
                DYE+   Y+F +FA   +P+      V  T+I    +ENDN P F   +  + + E
Sbjct: 646  RRQFDYESTQTYNFRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 703

Query: 472  NVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------ 513
            +      +  + A D D+G  G++ YF   D   F ++ +TG                  
Sbjct: 704  SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763

Query: 514  ---------------------------LIMLIARLDYELIQRFTLTIIARDGGG--EETT 544
                                       LI  +A LD E      +T++  D G      T
Sbjct: 764  GTDFAFSSDELQAFVLKSLFCELGEGELINWVA-LDREHRGHHEMTVLVTDRGSPPRNAT 822

Query: 545  GRVRINVLDVNDNVPTFQ-----KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYS 599
              V ++V D+NDN P F      K+ +V  L E +P    +  + A D D   N ++TYS
Sbjct: 823  MAVYVSVTDINDNRPFFPQCLPGKELHVKVL-EGQPVNMLVTTVFAKDPDEGNNAEVTYS 881

Query: 600  IVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTI 659
            + S  +   +F I    G    +     DY         ++V+A D G PPL     V I
Sbjct: 882  VSSEDS-SDHFKIDANNGEIRTTTILSYDYRPSYR----MSVIATDQGVPPLQGQAVVNI 936

Query: 660  EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI-IYSLEGSTQ 718
            +V   +      S+    + + EN+     +  + ++D  +    G+    I + +    
Sbjct: 937  QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT---VNITLLDINDNH 775
            F I++ +G++  +  LD ET S Y+  V   D    H++   +++   ++I + D ND+ 
Sbjct: 997  FEIDSSTGDLFLSKELDYETTSHYLFRVITTD----HSKNLSLSSTVFLSIDVEDQNDHS 1052

Query: 776  PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE-NGTLVYSIQ---PPNKFYSLNSTTG 831
            P+++D    I++ E  P  + V    A D D    N  + Y I+   P    + ++ + G
Sbjct: 1053 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112

Query: 832  KIRTTHAMLDREN-PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
             + T  + LDRE+ P            V+VTD      +   S T  + +LD+ND++PTF
Sbjct: 1113 TLVTV-SRLDRESIPTVILTVTASDQAVNVTD------RRLRSLTAQIVILDVNDHNPTF 1165

Query: 891  QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT 950
             + P  A V E +  G  ++ + A D DEG NG V+Y +  G   M F+++ SSG++ TT
Sbjct: 1166 ISFPN-AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV-P 1009
              LD E   ++ L V+A D GTP  SS+ TLT+ VLDVNDE P F   +Y  SV E+  P
Sbjct: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284

Query: 1010 REFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
             EF V  +   D D G+N++L + I  G     F +      V T   LDRE    + L 
Sbjct: 1285 GEF-VTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343

Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
            +   D G      + T T+  TV D ND+ P F+ SSY+  V E+  E   +  + A+D 
Sbjct: 1344 VLVRDGG--FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDM 1400

Query: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PM 1188
            D G    V Y I+ GN    F I+  +G L    R LDRE+ S+  L++     DLG P 
Sbjct: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELST-TRALDREQISNFTLVILC--SDLGDPP 1457

Query: 1189 RSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
            RSSV  + V V D ND +P F    Y +  +RE A +GT V+V+ A D+D G  G   Y 
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYY-QSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516

Query: 1248 ILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATD---QAPPFNQGFCSVYITLL 1304
            +   A G F ID  +G + T N LD E ++ +  +  A D   Q          VY+T +
Sbjct: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576

Query: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKI 1364
            N+ D  ++ +      +        T IVR     +     + + F      + +++F I
Sbjct: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-----AETQSMFSI 1631

Query: 1365 DAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
            D  TG I  Q     E    +    V D G P   +T  + +  ++  D    F      
Sbjct: 1632 DKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIP-ARTTTGLLVIHMEGEDVKISFSHHLYK 1690

Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
             + + E+C  G  + TVKA+ PD+     + +S+ SGN  G   + + +   G++ V  P
Sbjct: 1691 GL-VTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS---GQLTVKEP 1745

Query: 1485 --LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVG 1542
              LD E  +   L V+A   G     K   + V I D NDN P  E    Y  SV+E+  
Sbjct: 1746 KFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSI-YQASVSESQL 1801

Query: 1543 GGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
                V+QV ATD D G+N ++ Y I  GN++ AF++D +SG I T+ A  D E  S Y L
Sbjct: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK-AILDYELTSSYSL 1860

Query: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQALD 1661
            +    D+G P LS TT + V + D NDNAP F      E+  D  P  + T  +++  +D
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTH-VSVHDVD 1919

Query: 1662 LDEGPNGTVTYAIV-AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
            L    N    ++     N    F ID++ GV+   K LD+E     Y L++  +D     
Sbjct: 1920 L----NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYT 1974

Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNG 1777
               L      +V V D+NDN P F +D+   ++VT  E  P G  V T  A D +S  N 
Sbjct: 1975 EGAL------VVRVLDVNDNPPVFSQDF---YQVTVPESIPVGYSVLTLSATDLESNEN- 2024

Query: 1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1837
             + Y I+      EF I P  G +     V L  +TI+     + A D G P L +  LV
Sbjct: 2025 -ISYRILSSSK--EFSIDPKNGTIFTISPVLL-LDTISTTQFLVEASDGGNPDLRALTLV 2080

Query: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD-SGCNARLTFNITAGNRE 1896
             I + D+N+  P       N+++SE++ V S +      D D +  N  + ++I +GN +
Sbjct: 2081 EIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQ 2140

Query: 1897 RAFFINA----------TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
              F +              G + +   LDRE    ++L I   D+   P  +     ++ 
Sbjct: 2141 NNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTA---VIS 2197

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2005
            I + D NDN P F+  +Y   V E++P G+ +TV++    A D D   +A + Y ++ G 
Sbjct: 2198 IQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS----ANDRDTGSHAEIIYNIISGN 2253

Query: 2006 QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN-STAHLLITILDDND 2064
            + G F +  +TGV+ +     +D E  +     L + A D    + S A + +++LDDND
Sbjct: 2254 EKGHFYLEENTGVLYLIKP--LDYEKMTK--FTLTVQASDAEKKHFSFAVVFVSVLDDND 2309

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA---------QDR 2115
            + P F  ++ +  + EN P   ++  + A D D+G  GEL Y I +            D 
Sbjct: 2310 HAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL 2369

Query: 2116 FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
            FLI  +TG I      +D E    Y LTV A D+G    + + +V + I+ I++  P F 
Sbjct: 2370 FLIDPLTGDIH-AKQILDYENGNKYCLTVQAKDKGDA--TASLVVWVDIEGIDEFEPIFT 2426

Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
                  ++ E  +   +I  + A D D        I G++        +      F+VN 
Sbjct: 2427 QDQYFFTLPEKNKDRQLIGRVEASDADAG------IDGVILYS-----LGTSSPFFSVNK 2475

Query: 2236 NTGSV-------MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
              G++       ++KS +N+E   T E+ +      SD    S +V      VNV   ++
Sbjct: 2476 TNGNIYLIRALPLIKSQLNKE--DTLEMKIIAHSPKSDSKFASCTV-----FVNVSFSSE 2528

Query: 2289 NTP 2291
             TP
Sbjct: 2529 GTP 2531



 Score =  598 bits (1542), Expect = e-170
 Identities = 591/2094 (28%), Positives = 932/2094 (44%), Gaps = 169/2094 (8%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            IS+ TP G+++    A+D D   N  + + ++  +    FA++   GV++L   L    +
Sbjct: 489  ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQ 547

Query: 99   SEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAP--TFHNQPYSVRIPENTPVGTPIFI 153
             E T+     D QGV  +    V   V +  +++P  TF +  Y V + E+    T +  
Sbjct: 548  RELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 606

Query: 154  VNATDPDLG---AGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
              A    LG   A   + YS +P   S  F I    G + + R+ DYE+TQ Y   V A 
Sbjct: 607  TQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664

Query: 209  DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
              +     +    + + + D  D  P F++      + E   P   +  ITAID D G+ 
Sbjct: 665  IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724

Query: 269  RGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
              + Y ++S           G   +I+ + +  G    +G     +      F+L     
Sbjct: 725  GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784

Query: 318  ELND------------------------DRTPSDATVTTTFNILVIDINDNAPEF----N 349
            EL +                        DR       T    + V DINDN P F     
Sbjct: 785  ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844

Query: 350  SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG--NNSHHFIISPTSVQG 407
              E  V + E   V     L   V  KD + G N+    Y V   ++S HF I   +   
Sbjct: 845  GKELHVKVLEGQPVNM---LVTTVFAKDPDEG-NNAEVTYSVSSEDSSDHFKIDANN--- 897

Query: 408  KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
              +IR    +  DY    R    +  ++ VP   G A V I +I  +  R I SQ + ++
Sbjct: 898  -GEIRTTTILSYDYRPSYRMSV-IATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955

Query: 468  SLYENVTVGTSVLTVLATDNDAGTFGEVSYF--FSDDPD-RFSLDKDTGLIMLIARLDYE 524
             + EN+     +  + ++D+    +    +F   +DD D  F +D  TG + L   LDYE
Sbjct: 956  IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015

Query: 525  LIQRFTLTIIARDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
                +   +I  D        +T  + I+V D ND+ P+FQ +  V ++ EN P  T + 
Sbjct: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVY 1075

Query: 582  RLRATDED-SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
               A D+D S  N++I Y I S +   + F   ++  +G +     LD E I   ++ +T
Sbjct: 1076 VFNAKDDDGSFLNSRIQYYIESHNPGTNPF--LIHPSFGTLVTVSRLDRESIPTVILTVT 1133

Query: 641  V--MAMDAGNPPLNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATD 697
                A++  +  L S +   I + D ND+ PTF S P     V E++  G+ V  + A D
Sbjct: 1134 ASDQAVNVTDRRLRS-LTAQIVILDVNDHNPTFISFPN--AHVKEDVTVGSLVHHITAHD 1190

Query: 698  LDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 757
             D  R       I S   +  F ++  SG +TTT  LD E K+++IL V A+D G     
Sbjct: 1191 PDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGT--PA 1248

Query: 758  KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817
             +   T+ +T+LD+ND  P +K   Y  ++ E   P   VT V A+D D G N  L + I
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308

Query: 818  QPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
             P   F  + +NS TG++ TT  +LDR      E + +  + V V D G P L +T+  T
Sbjct: 1309 MPGASFELFEINSDTGEVVTT-TILDR------EIQEVFTLRVLVRDGGFPSLSSTT--T 1359

Query: 876  VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
            +   + D ND+ P F    +  EVLE     V +Y V+A D+D G N  V Y +  G   
Sbjct: 1360 ILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTD 1418

Query: 936  MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
              F IN  SG + TT  LDRE+I+ + L ++ SD G P +SS   L + VLD ND +P+F
Sbjct: 1419 ECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSF 1478

Query: 996  FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
                Y  SV ED      V+ L+  D D GLN +  YF+T     G F++      ++T 
Sbjct: 1479 PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT-DEASGAFTIDPMSGTLKTS 1537

Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
              LDRE  + +     A D    G R T T  + V V DVNDN P+  Q+ ++  +  + 
Sbjct: 1538 NTLDREARSQHTFSAVARDCSIQGSRST-TVIIKVYVTDVNDNDPVLEQNPFDVFLSPES 1596

Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
            P   + + ++A D D G  G V +        + F I    G +     P     +    
Sbjct: 1597 PTNQTTVIVRADDLDLGPNGTVVFSFAETQ--SMFSIDKYTGEIQFQQNP----SSEYFP 1650

Query: 1176 LIVEAYNHDLG-PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234
            + ++    D G P R++  ++V   +  D    F+   Y  L + E    GTS++ V+A 
Sbjct: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL-VTENCEAGTSIVTVKAF 1709

Query: 1235 DRDSGDGGLVNYRILSGAE-GKFEIDESTGLIIT--VNYLDYETKTSYMMNVSATDQAPP 1291
              DS    +  Y I SG E G   +   +G +      +LD+E +    + V A      
Sbjct: 1710 APDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-- 1766

Query: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFN 1351
             ++ +C V + + +E D +  F  + Y+A++ E+      +++V A  +D+       ++
Sbjct: 1767 -HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYS 1825

Query: 1352 AYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLD 1410
              +  Q +A F+IDA++GVIT + ++D E    Y+L V A D G P++ +T  + + V D
Sbjct: 1826 ILSGNQEEA-FQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884

Query: 1411 ENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIV 1470
             NDN+P   F    AV I ED   G  V  V   D D   N   +FS A  +  G    +
Sbjct: 1885 INDNAPA--FLPSEAVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAI 1940

Query: 1471 TTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESP 1530
              N   G V + + LD EE+  Y L +  SD        +  L V +LD+NDNPPV    
Sbjct: 1941 DQN--TGVVVLVKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQD 1995

Query: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPA 1590
            F Y V+V E++  G +V+ + AT  D+  N  +SY I   +K+  F +D  +G I T   
Sbjct: 1996 F-YQVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKE--FSIDPKNGTIFTISP 2050

Query: 1591 PPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL 1650
                +  S    +    D G P L A T V + I D N+ AP F    Y + L E    +
Sbjct: 2051 VLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA-LV 2109

Query: 1651 NTSLITIQALDLD-EGPNGTVTYAIVAGNIVNTFRID----------RHMGVITAAKELD 1699
             ++L+T   +D D    N  V Y+I++GN  N F ++          + +G +     LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169

Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
             E S     +I+ +   CP LS    ST  + + V D+NDN P F         V E  P
Sbjct: 2170 REASASHELVILASDSGCPPLS----STAVISIQVLDVNDNPPNF-SSLSYHTHVKESTP 2224

Query: 1760 -GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYN 1818
             G  +    A+DRD+G + ++ Y+I+ G+  G F +    GVL + K   LD E +  + 
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK--PLDYEKMTKFT 2282

Query: 1819 LTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDA 1878
            LT+ A D      S   +V + VLD ND+ P  +    +  + EN P+SS +  + A D 
Sbjct: 2283 LTVQASDAEKKHFSFA-VVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341

Query: 1879 DSGCNARLTFNITA--------GNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
            D+G    LT++I +              F I+  TG +   + LD E   +Y LT+  KD
Sbjct: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401

Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
              +          ++ + +   ++  P+FT+  Y   + E +        L G + A DA
Sbjct: 2402 KGDATASL-----VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD----RQLIGRVEASDA 2452

Query: 1991 DQDIYAVVTYQLLGAQSGLFDINSSTG-VVTVRSGVIIDREAFSPPILELLLLA 2043
            D  I  V+ Y  LG  S  F +N + G +  +R+  +I  +      LE+ ++A
Sbjct: 2453 DAGIDGVILYS-LGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA 2505



 Score =  578 bits (1491), Expect = e-164
 Identities = 618/2184 (28%), Positives = 970/2184 (44%), Gaps = 218/2184 (9%)

Query: 798  TTVVAVDPDLGENGTLVYSI-------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEA 850
            T V A D D G  G + YS+       + P  F  ++   G+I  +   +DRE  DP   
Sbjct: 77   TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATY 133

Query: 851  ELMRKIVVS----VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
            +L+ +        +T         ++ A V V+L D+NDN P F    +V  + +    G
Sbjct: 134  DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193

Query: 907  VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
              I  V+A D D G+ G V+Y +  G     F I+S++G+     E+         L  V
Sbjct: 194  TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI---------LSAV 244

Query: 967  ASDAGTPTKSSTS---TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR----VVWLNC 1019
               A     +S      L  H   V  +      A      S      F+    + +L  
Sbjct: 245  NFSADKEVMNSLEMFLPLLRHFKKVERDEEA---AEKKFEASRGWFMRFKGRRHLHYLKV 301

Query: 1020 TDNDVGLNAELS--YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
             D     + E +  Y      + G       + ++   + L    +    L++ A D G 
Sbjct: 302  QDEAASADGEAAARYVANLAKILG-------EGIIYLTLPLSHLESTTLSLMVSAQDGG- 353

Query: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
             G      A V + +         F +  Y   V ED+PE   I  +KA +        +
Sbjct: 354  -GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPI 411

Query: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG--PMRSSVRVI 1195
            +YRI  G+ G  F IH   G + R  +PLD E     VL V+A    LG  P  SS  V 
Sbjct: 412  FYRISSGDLGGKFSIHPRLGTI-RTRKPLDHETQPVVVLTVQA---QLGSAPACSSTEVN 467

Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
            + V D+ND  P F +     + + +T   GT++ + +A DRDSG  GL+ Y I S   G 
Sbjct: 468  ITVMDVNDNHPAFLRTS-DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV 526

Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITL-LNELDEAVQFS 1314
            F ID + G++     L    +    + + A DQ          + + +   E   +  F 
Sbjct: 527  FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 586

Query: 1315 NASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
            +  Y+  + E+L+  T++++ QA+ +      +    +   +   A+F I   TG I ++
Sbjct: 587  HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 646

Query: 1375 GLVDREKGDFYTLTVVA---DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
               D E    Y   V A   +DG  +  ST  V + V DENDNSP   F  D      E+
Sbjct: 647  RQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSP--TFLHDVLFLKVEE 703

Query: 1432 CPVGQRV-ATVKAWDPDAGSNGQVVFSLASG----------NIAGAFEIVTTNDSI---- 1476
             PV Q V   + A D D+G NGQ+++ L S             AG   ++T  D      
Sbjct: 704  SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763

Query: 1477 -------------------------GEVFVARPLDREELDHYILQVVASDRGTPPRKKDH 1511
                                     GE+     LDRE   H+ + V+ +DRG+PPR    
Sbjct: 764  GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 823

Query: 1512 ILQVTILDINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
             + V++ DINDN P           +V V E       V  V A D D G N+ ++Y ++
Sbjct: 824  AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 883

Query: 1569 EGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
              +    F++D  +GEI T        R S Y +     D+G P L     V + ++  +
Sbjct: 884  SEDSSDHFKIDANNGEIRTTTILSYDYRPS-YRMSVIATDQGVPPLQGQAVVNIQVIPLS 942

Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH 1688
                +  Q    +++ E         +   +  L +  NG + ++IVA +    F ID  
Sbjct: 943  KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSS 1002

Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
             G +  +KELDYE +   Y   V  TD    LS  L+ST  + ++V D ND+ P+F +D 
Sbjct: 1003 TGDLFLSKELDYETT-SHYLFRVITTDHSKNLS--LSSTVFLSIDVEDQNDHSPSF-QDE 1058

Query: 1749 EGPFEVTEGQP-GPRVWTFLAHDRD-SGPNGQVEYSIMDGDP-LGEFVISPVEGVLRVRK 1805
                 V E  P G  V+ F A D D S  N +++Y I   +P    F+I P  G L    
Sbjct: 1059 LIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVS 1118

Query: 1806 DVELDRETIAFYNLTICARDRGMPPLS---STMLVGIRVLDINDNDPVLLNLPMNITISE 1862
               LDRE+I    LT+ A D+ +        ++   I +LD+ND++P  ++ P N  + E
Sbjct: 1119 --RLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKE 1175

Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
            +  V S V H+ A D D G N ++T++I +GN    F ++ ++G++T   PLD E   ++
Sbjct: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235

Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
             LT+   D+      A      L + + D ND  P+F +  Y+A V EN   G  +T   
Sbjct: 1236 ILTVLALDDGTP---ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT--- 1289

Query: 1983 GPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
              + ALD D  + + + ++++ GA   LF+INS TG V   +  I+DRE      L +L+
Sbjct: 1290 -RVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT--ILDREIQEVFTLRVLV 1346

Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
                   L+ST  +L T+ D+ND+ P F  ++  + +LEN  P   V  V A+D D+G N
Sbjct: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNN 1405

Query: 2102 GELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
              + Y I  G  D  F I+ ++G +    A +DRE+  ++ L ++ +D G  P S    +
Sbjct: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRA-LDREQISNFTLVILCSDLGDPPRSSVIHL 1464

Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKD 2218
             + + D ND  P F       SV E AE GTV+  ++A+D D  LN + EY         
Sbjct: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF-------- 1516

Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
                L      AF ++  +G++   + ++RE  A  + T S +  A D   +        
Sbjct: 1517 ----LTDEASGAFTIDPMSGTLKTSNTLDRE--ARSQHTFSAV--ARDCSIQGSRSTTVI 1568

Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 2338
            + V V DVNDN P  +      ++    E  T  TT+I V A D D G NG V ++  + 
Sbjct: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSP--ESPTNQTTVI-VRADDLDLGPNGTVVFSFAET 1625

Query: 2339 VPPGYVQLEDSSAGKV--IANRTVDYEEVHWLNFTVRASDNGSPPRAAE--IPVYLEIVD 2394
                 +   D   G++    N + +Y  + WL   ++ +D G P R     + +++E  D
Sbjct: 1626 QSMFSI---DKYTGEIQFQQNPSSEYFPI-WLQ--LKVTDQGIPARTTTGLLVIHMEGED 1679

Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINP 2452
            +  +   F    Y+  V E+   GT I+TV A   DS   ++ +YS+  G+ +   ++  
Sbjct: 1680 VKIS---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCS 1735

Query: 2453 TTGDIYVLSS--LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
             +G + V     LD E ++   L  LA+      + +R    V V+IQ  D ND  P F 
Sbjct: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAES-----SGHRAYCKVAVLIQ--DENDNSPCFE 1788

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS-LEGPGVEAFHVDMDSGLVTTQR 2569
            +  +  SV E++     VI + ATD D G NG + YS L G   EAF +D  SG++TT +
Sbjct: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITT-K 1847

Query: 2570 PLQSYE---KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEI 2626
             +  YE    +SL V ATD G P L  TT++ V+V D+NDN P F+  P+  +    + +
Sbjct: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL--PSEAVEITEDSL 1905

Query: 2627 PLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV 2686
            P    V   + +  D  LN A  +SF K   +     F ID  +G++   + LD E    
Sbjct: 1906 P---GVIVTHVSVHDVDLNSAFIFSFAKE--SNPGTKFAIDQNTGVVVLVKTLDFEEMTE 1960

Query: 2687 YSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
            Y L++  SD    V Y T   L V + D++DN P+F      S  +  +TVPE  P G  
Sbjct: 1961 YELLIQISD---SVHY-TEGALVVRVLDVNDNPPVF------SQDFYQVTVPESIPVGYS 2010

Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRD-LDREREAIFSFIVK 2804
            V  ++ A D +   N I Y  +++    K F + P +G +  +   L  +  +   F+V+
Sbjct: 2011 VLTLS-ATDLESNEN-ISYRILSS---SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065

Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
            AS         G +P L     LTL E+ +  ED+N+  P FT   Y   ++ DA VGS 
Sbjct: 2066 ASD--------GGNPDL---RALTLVEIGI--EDMNNYAPEFTVKSYNLSLSEDALVGST 2112

Query: 2865 LIQVLALDAD-IGNNSLVFYSILA 2887
            L+    +D D    N+ V YSI++
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIIS 2136



 Score =  531 bits (1367), Expect = e-150
 Identities = 588/2130 (27%), Positives = 911/2130 (42%), Gaps = 195/2130 (9%)

Query: 845  PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIP 904
            P  H       ++VS  D G   L A  +A V +++         F+   +   V E +P
Sbjct: 334  PLSHLESTTLSLMVSAQDGGG--LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 391

Query: 905  AGVSIYQVVAIDLDEGLNGL--VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQ 962
                I  V A    E LN    + YR+  G     F I+   G + T   LD E      
Sbjct: 392  EDSPIGTVKA---REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 448

Query: 963  LRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
            L V A     P  SST  + I V+DVND  P F      + +S+  P    +      D 
Sbjct: 449  LTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR 507

Query: 1023 DVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRH 1082
            D G N  + Y I      G F++     V+     L         L L A D G     H
Sbjct: 508  DSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV----H 562

Query: 1083 TGTATVFVTV-LDVNDNRP--IFLQSSYEASVPEDIPEGHSILQLKATD-ADEGEFGRVW 1138
               A + +TV ++  ++ P   F    Y+  V E +     +LQ +A     +     + 
Sbjct: 563  PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 622

Query: 1139 YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRS-SVRVIVY 1197
            Y +        F I    G +    R  D E   ++   V A+  + G +++ S  VIV 
Sbjct: 623  YSLEPSVDSAMFGIRPYTGWIYLR-RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 681

Query: 1198 VEDINDEAPVFTQQQYSRLGLR-ETAGIGTSVI-VVQATDRDSGDGGLVNYRILS----- 1250
            V D ND +P F    +  L L+ E + +   VI  + A D DSG  G + Y +LS     
Sbjct: 682  VWDENDNSPTFL---HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFF 738

Query: 1251 -------------------------GAEGKFEIDESTGLIIT-----------VNY--LD 1272
                                     G +  F  DE    ++            +N+  LD
Sbjct: 739  KMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALD 798

Query: 1273 YETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNA----SYEAAILENLAL 1328
             E +  + M V  TD+  P      +VY+++ +  D    F            +LE   +
Sbjct: 799  REHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPV 858

Query: 1329 GTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
               +  V A   D  N  ++TY  ++  S+     FKIDA  G I    ++  +    Y 
Sbjct: 859  NMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH---FKIDANNGEIRTTTILSYDYRPSYR 915

Query: 1387 LTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWD 1445
            ++V+A D G P +     V I V+  +             + IPE+    + ++ +K+ D
Sbjct: 916  MSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI-IPENLKPTKIMSLIKSSD 974

Query: 1446 P-DAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGT 1504
                  NG++ FS+ + +  G FEI   + S G++F+++ LD E   HY+ +V+ +D   
Sbjct: 975  HLQQHYNGKLHFSIVADDKDGHFEI---DSSTGDLFLSKELDYETTSHYLFRVITTDHSK 1031

Query: 1505 PPRKKDHI-LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG-INSV 1562
                   + L + + D ND+ P  +      +SV ENV  GT V    A D D   +NS 
Sbjct: 1032 NLSLSSTVFLSIDVEDQNDHSPSFQDEL-IVISVEENVPIGTLVYVFNAKDDDGSFLNSR 1090

Query: 1563 LSYYITEGNKDM-AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG---TPTLSATT 1618
            + YYI   N     F +    G + T  +  DRE      L  T  D+    T     + 
Sbjct: 1091 IQYYIESHNPGTNPFLIHPSFGTLVT-VSRLDRESIPTVILTVTASDQAVNVTDRRLRSL 1149

Query: 1619 HVYVTIVDENDNAPMFQQ-PHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAG 1677
               + I+D ND+ P F   P+  V  D    T+ + +  I A D DEG NG VTY+I++G
Sbjct: 1150 TAQIVILDVNDHNPTFISFPNAHVKEDV---TVGSLVHHITAHDPDEGRNGKVTYSILSG 1206

Query: 1678 NIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDI 1737
            N   TF +D   G++T    LDYE+       ++   D  P LS   T T TVL    D+
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL----DV 1262

Query: 1738 NDNVPTFPRD-YEGPFEVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
            ND  P F +  YE    V E Q PG  V    A DRDSG N ++++ IM G     F I+
Sbjct: 1263 NDEAPVFKQHLYEA--SVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320

Query: 1796 PVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLP 1855
               G   V     LDRE    + L +  RD G P LSST  +   V D ND+ P  +   
Sbjct: 1321 SDTG--EVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS 1378

Query: 1856 MNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLD 1915
             +I + EN      V  VLASD D+G N  + ++I  GN +  F IN  +G ++  R LD
Sbjct: 1379 YDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALD 1437

Query: 1916 RERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAG 1975
            RE+I  + L I   D  + PR +     + ++   D ND+ P F    YQ+ V E++  G
Sbjct: 1438 REQISNFTLVILCSDLGDPPRSSVIHLQVRVL---DANDHSPSFPTLYYQSSVREDAEVG 1494

Query: 1976 TPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPP 2035
            T + VL+    A+D D+ +     Y L    SG F I+  +G  T+++   +DREA S  
Sbjct: 1495 TVVLVLS----AVDKDEGLNGQTEYFLTDEASGAFTIDPMSG--TLKTSNTLDREARSQH 1548

Query: 2036 ILELLLLAEDI-GLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT 2094
                +     I G  ++T  + + + D NDN P        V L    P   + + V A 
Sbjct: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRAD 1608

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154
            D D G NG +V+   A  Q  F I   TG I+         E     L +  TD+G    
Sbjct: 1609 DLDLGPNGTVVFSF-AETQSMFSIDKYTGEIQFQQNP--SSEYFPIWLQLKVTDQGIPAR 1665

Query: 2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-LNPKLEYHIVG 2213
            + T ++ I ++   D +  F + +    V E+ E GT I  + A   D +   ++Y I  
Sbjct: 1666 TTTGLLVIHMEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFS 1724

Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS 2273
                        N++   ++   +G + VK P   +     EV L V      L E S  
Sbjct: 1725 -----------GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV------LAESSGH 1767

Query: 2274 VPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
                K+ V + D NDN+P F+    + Y   + E       +I V A D D GLNGL+ Y
Sbjct: 1768 RAYCKVAVLIQDENDNSPCFEQ---SIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824

Query: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
            ++L        Q+ D+ +G +     +DYE     +  V+A+D G P  +    + +++ 
Sbjct: 1825 SILSGNQEEAFQI-DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVT 1883

Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE-SKFAINP 2452
            DINDN P F  PS    + ED   G I+  V+  D D  +  +  ++      +KFAI+ 
Sbjct: 1884 DINDNAPAF-LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQ 1942

Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
             TG + ++ +LD E+   Y L     D+              +V++VLDVND  P FS+ 
Sbjct: 1943 NTGVVVLVKTLDFEEMTEYELLIQISDSV-------HYTEGALVVRVLDVNDNPPVFSQD 1995

Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ 2572
             +  +V E+ P G SV+T+ ATD +   N  ++Y +     E F +D  +G + T  P+ 
Sbjct: 1996 FYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE-FSIDPKNGTIFTISPVL 2052

Query: 2573 SYEKFSLT---VVATDGGEPPLWGTTMLLVEVIDVNDNRPVF-VRPPNGTILHIREEIPL 2628
              +  S T   V A+DGG P L   T++ + + D+N+  P F V+  N   L + E+  +
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN---LSLSEDALV 2109

Query: 2629 RSNVYEVYATDKD-EGLNGAVRYSFLKTAGNRDWEFFIIDPIS---------GLIQTAQR 2678
             S +      D D    N  V YS +  +GN    F +              G +     
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSII--SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            LDRE+ A + L+++ASD G P P  +   + + + D++DN P F      S  Y    V 
Sbjct: 2168 LDREASASHELVILASDSGCP-PLSSTAVISIQVLDVNDNPPNF-----SSLSYHT-HVK 2220

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREA 2797
            E +P G+ +  V  A D D G +A + Y I +GNE+ +F+L+ + G L +++ LD E+  
Sbjct: 2221 ESTPLGSHI-TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMT 2279

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             F+  V+AS                     +   V V + D ND  P+F  + ++  V  
Sbjct: 2280 KFTLTVQASDAEK--------------KHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILA 2887
            +  + S +  + ALD D G    + YSI++
Sbjct: 2326 NLPISSTICSINALDFDAGPYGELTYSIVS 2355



 Score =  514 bits (1324), Expect = e-145
 Identities = 493/1761 (27%), Positives = 807/1761 (45%), Gaps = 131/1761 (7%)

Query: 37   DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPL 93
            + ++ + E  PV   VT + A+D D   N  + + VS E++S  F ++ + G +     L
Sbjct: 847  ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906

Query: 94   DRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
              + +  + +    +D QGV   +    VNIQV  ++            + IPEN     
Sbjct: 907  SYDYRPSYRMSVIATD-QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965

Query: 150  PIFIVNATDP-DLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVN 206
             + ++ ++D       G + +S     +   F IDS+ G + + +ELDYETT  Y   V 
Sbjct: 966  IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025

Query: 207  ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
             TD  K   LS+   L+I + D  D  P F +     ++ E+ P GT V +  A D D  
Sbjct: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGS 1085

Query: 267  RPRG-IGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE----LN 320
                 I Y I S N   + F +    G L     LDRE+       ILTV  ++    + 
Sbjct: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES---IPTVILTVTASDQAVNVT 1142

Query: 321  DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
            D R  S      T  I+++D+ND+ P F S   +  + E   VG +L   I   D DE  
Sbjct: 1143 DRRLRS-----LTAQIVILDVNDHNPTFISFP-NAHVKEDVTVG-SLVHHITAHDPDEGR 1195

Query: 381  GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPD 439
                 + + L GN +  F++  +S        +    PLDYE   ++   + A ++  P 
Sbjct: 1196 NGKVTYSI-LSGNENMTFMLDESSG------LLTTTCPLDYEMKTQHILTVLALDDGTPA 1248

Query: 440  HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
                  + +T+++ ND  P+F Q LY  S+ EN   G  V  V A D D+G   ++ +  
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308

Query: 500  SDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVN 555
                  + F ++ DTG ++    LD E+ + FTL ++ RDGG     +T  +   V D N
Sbjct: 1309 MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN 1368

Query: 556  DNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
            D+ P F   +Y +  L   EP V   V   A+D D+  N  + Y I+  +    +   ++
Sbjct: 1369 DHAPEFIVSSYDIEVLENQEPEVVYTV--LASDMDAGNNRAVEYHIIDGNTDECF---TI 1423

Query: 615  YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 674
             E  G +S +R LD EQISN    L ++  D G+PP +S + + + V D ND+ P+F   
Sbjct: 1424 NEMSGELSTTRALDREQISN--FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481

Query: 675  AYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
             Y  SV E+   G  VL L+A D D     GQ     + E S  F I+  SG + T++ L
Sbjct: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLN-GQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540

Query: 735  DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
            DRE +S++     A D  +  ++ T +  + + + D+NDN P  +  P+ + L   +P +
Sbjct: 1541 DREARSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599

Query: 795  SDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
                 V A D DLG NGT+V+S       +S++  TG+I+       ++NP      +  
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQF------QQNPSSEYFPIW- 1652

Query: 855  KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
             + + VTD G P   A ++  + V  ++  D   +F +  +   V E   AG SI  V A
Sbjct: 1653 -LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708

Query: 915  IDLDEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASDAGT 972
               D  +   + Y +  G       + S SG   V     LD E   E QL V+A  +G 
Sbjct: 1709 FAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH 1767

Query: 973  PTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1032
                  + L   + D ND +P F  ++Y  SVSE       V+ +  TD D GLN  + Y
Sbjct: 1768 RAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824

Query: 1033 FITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTV 1092
             I  GN +  F +     V+ T   LD E T++Y LI++A D G    R + T  + V V
Sbjct: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGM--PRLSNTTVIKVQV 1882

Query: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
             D+NDN P FL S     + ED   G  +  +   D D      ++      N G  F I
Sbjct: 1883 TDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNS-AFIFSFAKESNPGTKFAI 1940

Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
              + G+++   + LD E  + + L+++  +       +   ++V V D+ND  PVF+Q  
Sbjct: 1941 DQNTGVVVL-VKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQDF 1996

Query: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVN-YL 1271
            Y ++ + E+  +G SV+ + ATD +S +   ++YRILS ++ +F ID   G I T++  L
Sbjct: 1997 Y-QVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK-EFSIDPKNGTIFTISPVL 2052

Query: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTE 1331
              +T ++    V A+D   P  +    V I + +  + A +F+  SY  ++ E+  +G+ 
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112

Query: 1332 IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA----------ITGVITVQGLVDREK 1381
            +V       D   + TY   +  S  ++  F ++             G + +   +DRE 
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172

Query: 1382 GDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
               + L ++A D G P + ST  + I VLD NDN P F   S     + E  P+G  +  
Sbjct: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS-YHTHVKESTPLGSHITV 2231

Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
            V A D D GS+ ++++++ SGN  G F +    ++ G +++ +PLD E++  + L V AS
Sbjct: 2232 VSANDRDTGSHAEIIYNIISGNEKGHFYL---EENTGVLYLIKPLDYEKMTKFTLTVQAS 2288

Query: 1501 DRGTPPRKKDH----ILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD 1556
            D      +K H    ++ V++LD ND+ P       ++  V EN+   + +  + A D D
Sbjct: 2289 D-----AEKKHFSFAVVFVSVLDDNDHAPQFMFS-SFSCIVPENLPISSTICSINALDFD 2342

Query: 1557 IGINSVLSY------YITEG---NKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
             G    L+Y      ++T G   + D+ F +D ++G+I  +    D E  + Y L    +
Sbjct: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDL-FLIDPLTGDIHAKQI-LDYENGNKYCLTVQAK 2400

Query: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGP 1666
            D+G  T S    V +  +DE +  P+F Q  Y   L E     +  LI  ++A D D G 
Sbjct: 2401 DKGDATASLVVWVDIEGIDEFE--PIFTQDQYFFTLPE--KNKDRQLIGRVEASDADAGI 2456

Query: 1667 NGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTS 1726
            +G + Y++  G     F +++  G I   + L    S     L    T +  I++H   S
Sbjct: 2457 DGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQ----LNKEDTLEMKIIAHSPKS 2510

Query: 1727 -----TTTVLVNVNDINDNVP 1742
                 + TV VNV+  ++  P
Sbjct: 2511 DSKFASCTVFVNVSFSSEGTP 2531



 Score =  464 bits (1194), Expect = e-130
 Identities = 520/1942 (26%), Positives = 840/1942 (43%), Gaps = 251/1942 (12%)

Query: 1123 QLKATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLI 1177
            ++ A+DAD G +G + Y +  G         FRI   +G +    + +DRER+ +++ L+
Sbjct: 78   EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLL 136

Query: 1178 VEAYNHD----------LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTS 1227
            VEA + D           G + +   V V +ED+ND  PVF    Y      ET   GT 
Sbjct: 137  VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQP-GTE 195

Query: 1228 VIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSAT 1286
            +I V ATD+DSG  G V Y ++ G     F ID +TGL        Y  +   +  V+ +
Sbjct: 196  IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--------YSPEVEILSAVNFS 247

Query: 1287 DQAPPFNQGFCSVYITLLNELDEAVQFSNAS---YEAA----ILENLALGTEIVRVQAYS 1339
                  N     +++ LL    +  +   A+   +EA+    +          ++VQ  +
Sbjct: 248  ADKEVMNS--LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEA 305

Query: 1340 IDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP--- 1396
                 +   R   Y +  AK L +     G+I +   +   +    +L V A DGG    
Sbjct: 306  ASADGEAAAR---YVANLAKILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTA 357

Query: 1397 --KVDSTVKVYITVLDEND-NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
                D T+ ++ T L   +   P++ F       +PED P+G    TVKA +P   S+  
Sbjct: 358  VINADVTIHIFQTTLAPAEFERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEP 410

Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
            + + ++SG++ G F I   +  +G +   +PLD E     +L V A   G+ P      +
Sbjct: 411  IFYRISSGDLGGKFSI---HPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEV 466

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
             +T++D+NDN P         + +++    GTA+   RA DRD G N ++ Y I      
Sbjct: 467  NITVMDVNDNHPAFLRTSD-EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG 525

Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
            + F +DR  G +    +    E++    L    ED+G    +A   V   ++++ +++P 
Sbjct: 526  V-FAIDRALGVLFLNGSLGAGEQRELT-LTLRAEDQGVHPQAALL-VLTVVIEKREHSPS 582

Query: 1634 FQQPH--YEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT---YAIVAGNIVNTFRIDRH 1688
            +   H  Y+V + E    + T ++  QA  L  GP    +   Y++        F I  +
Sbjct: 583  WTFEHLVYQVEVSESLSPM-TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPY 639

Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
             G I   ++ DYE S   Y   V A    P        +TTV+V V D NDN PTF  D 
Sbjct: 640  TGWIYLRRQFDYE-STQTYNFRVFAW--IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 696

Query: 1749 EGPFEVTEGQPGPR--VWTFLAHDRDSGPNGQVEYSIM-DGD---------PLG------ 1790
               F   E  P P+  +    A D DSG NGQ+ Y ++ DG          P G      
Sbjct: 697  L--FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754

Query: 1791 -----------EFVISPVEGVLRVRKD-------------VELDRETIAFYNLTICARDR 1826
                       +F  S  E    V K              V LDRE    + +T+   DR
Sbjct: 755  WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814

Query: 1827 GMPPLSSTMLVGIRVLDINDNDPV----LLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
            G PP ++TM V + V DINDN P     L    +++ + E  PV+  V  V A D D G 
Sbjct: 815  GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874

Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
            NA +T+++++ +    F I+A  G +     L  +  P Y++++   D    P   +   
Sbjct: 875  NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934

Query: 1943 DLLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTV-LNGPI-LALDADQDI 1994
            ++ +I LS       +N  H +  ++    ++M    +   L    NG +  ++ AD   
Sbjct: 935  NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD-- 992

Query: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-LNSTA 2053
                       + G F+I+SSTG + +     +D E  S  +  ++       L L+ST 
Sbjct: 993  -----------KDGHFEIDSSTGDLFLSKE--LDYETTSHYLFRVITTDHSKNLSLSSTV 1039

Query: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED-SGLNGELVYRIEAG- 2111
             L I + D ND+ P+F    + + + EN P G  V    A D+D S LN  + Y IE+  
Sbjct: 1040 FLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHN 1099

Query: 2112 -AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG---TVPLSGTAIVTILIDDI 2167
               + FLIH   G + V  + +DRE   +  LTV A+D+    T     +    I+I D+
Sbjct: 1100 PGTNPFLIHPSFGTL-VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDV 1158

Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVP 2225
            ND  P F++      V E    G+++ +ITA D D   N K+ Y I           L  
Sbjct: 1159 NDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSI-----------LSG 1206

Query: 2226 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
            N+   F ++ ++G +    P++ E+   + +T+  +D+ +     S +     LTV VLD
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQT-----LTVTVLD 1261

Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
            VND  P FK      Y   + E   PG  +  V A+D D G+N  + +   +++P    +
Sbjct: 1262 VNDEAPVFKQH---LYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF---EIMPGASFE 1315

Query: 2346 LED--SSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
            L +  S  G+V+    +D E        V   D G P  ++   +   + D ND+ P F 
Sbjct: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375

Query: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLS 2461
              SY   V E+     ++ TV A+D D+GN   +EY + DG +   F IN  +G++    
Sbjct: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434

Query: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
            +LDRE+  ++ L  L  D    +    R + + + ++VLD ND  P F    + +SV E+
Sbjct: 1435 ALDREQISNFTLVILCSD----LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED 1490

Query: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
               GT V+ + A D+DEG NG+  Y L      AF +D  SG + T   L  ++  + + 
Sbjct: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTF 1550

Query: 2580 TVVATDGGEPPLWGTTMLL-VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
            + VA D        TT+++ V V DVNDN PV  + P    L    E P       V A 
Sbjct: 1551 SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS--PESPTNQTTVIVRAD 1608

Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
            D D G NG V +SF +T        F ID  +G IQ  Q    E   ++  + V     Q
Sbjct: 1609 DLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTD---Q 1660

Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
             +P  T   L V   + +D +  F      S       V E+   GT +  VT    A +
Sbjct: 1661 GIPARTTTGLLVIHMEGEDVKISF------SHHLYKGLVTENCEAGTSI--VTVKAFAPD 1712

Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----DLDREREAIFSFIVKASSNRSWTP 2813
                 + Y I +GNE+    L      L ++     D +   E     + ++S +R++  
Sbjct: 1713 SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYC- 1771

Query: 2814 PRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
                             +V V+++D ND  P F ++ Y A V+      + +IQV A D 
Sbjct: 1772 -----------------KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814

Query: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT-----FDLFMAYSPGYF 2928
            D G N L+ YSIL           S +  + F + ++ G++ T     ++L  +YS    
Sbjct: 1815 DSGLNGLIEYSIL-----------SGNQEEAFQIDALSGVITTKAILDYELTSSYS---L 1860

Query: 2929 VVDIVARDLAGHNDTAIIGIYI 2950
            +V    + +   ++T +I + +
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQV 1882



 Score =  342 bits (878), Expect = 3e-93
 Identities = 329/1167 (28%), Positives = 525/1167 (44%), Gaps = 98/1167 (8%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
            P F    +D  +L +++  V   V  +LA DMD   N  + + +        F +   +G
Sbjct: 1372 PEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG 1428

Query: 86   VVWLRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
             +   + LDRE  S FT+    SD        VI   + ++V D ND++P+F    Y   
Sbjct: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVI--HLQVRVLDANDHSPSFPTLYYQSS 1486

Query: 141  IPENTPVGTPIFIVNATDPDLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQ 199
            + E+  VGT + +++A D D G  G   Y      S  F ID   G +     LD E   
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARS 1546

Query: 200  AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
             +  +  A D       ST   + + +TDV D DP+    P+   +   SP   T  I+ 
Sbjct: 1547 QHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606

Query: 260  AIDQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
            A D D G P G   T+V     T S+F++D  +G +       ++NP  S  +       
Sbjct: 1607 ADDLDLG-PNG---TVVFSFAETQSMFSIDKYTGEIQF-----QQNP--SSEYFPIWLQL 1655

Query: 318  ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
            ++ D   P  A  TT   ++ ++  D    F+   Y   +TE  + G ++   + V    
Sbjct: 1656 KVTDQGIP--ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFA 1710

Query: 378  ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
             +   +SM   Y + + +   ++S  S  G+  + ++    LD+E  +     + A  S 
Sbjct: 1711 PDSIQDSM--KYSIFSGNEDGVLSLCSKSGQ--LTVKEPKFLDFEVRNEVQLIVLAESS- 1765

Query: 438  PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG--EV 495
              H  Y KV + + +ENDN P F Q +Y  S+ E+      V+ V ATD D+G  G  E 
Sbjct: 1766 -GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824

Query: 496  SYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLD 553
            S    +  + F +D  +G+I   A LDYEL   ++L + A D G      T  +++ V D
Sbjct: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884

Query: 554  VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
            +NDN P F       A+   E S+  ++    +  D   N+   +S    S  G+ F I 
Sbjct: 1885 INDNAPAFLPSE---AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAID 1941

Query: 614  LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK 673
              +  GV+ + + LD+E+++     L +   D+ +    + V   + V D NDNPP FS+
Sbjct: 1942 --QNTGVVVLVKTLDFEEMTE--YELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQ 1994

Query: 674  PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTS 732
              Y V+V E+I  G +VL L+ATDL+       E+I Y  L  S +F I+ ++G I T S
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLE-----SNENISYRILSSSKEFSIDPKNGTIFTIS 2049

Query: 733  -LLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
             +L  +T S    +V A DG  G+     +  V I + D+N+  P +    Y ++L E  
Sbjct: 2050 PVLLLDTISTTQFLVEASDG--GNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA 2107

Query: 792  PPDSDVTTVVAVDPDLGENGTLV-YSIQPPN---------KFYSLN---STTGKIRTTHA 838
               S + T   +D D     T V YSI   N         KF+         G +   H+
Sbjct: 2108 LVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167

Query: 839  MLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAE 898
             LDRE    HE      +V+  +D G PPL  +S+A + + +LD+NDN P F +L +   
Sbjct: 2168 -LDREASASHE------LVILASDSGCPPL--SSTAVISIQVLDVNDNPPNFSSLSYHTH 2218

Query: 899  VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI 958
            V E  P G  I  V A D D G +  + Y +  G  +  F +  ++GV+     LD E++
Sbjct: 2219 VKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKM 2278

Query: 959  AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018
             ++ L V ASDA      S + + + VLD ND  P F  + ++  V E++P    +  +N
Sbjct: 2279 TKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN 2337

Query: 1019 CTDNDVGLNAELSY------FITGGNV--DGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
              D D G   EL+Y      F+T G       F +      +     LD E    Y L +
Sbjct: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV 2397

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            +A D G      T +  V+V +  +++  PIF Q  Y  ++PE   +   I +++A+DAD
Sbjct: 2398 QAKDKGDA----TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453

Query: 1131 EGEFGRVWYRILHGNHGNNFRIHVSNG 1157
             G  G + Y +  G     F ++ +NG
Sbjct: 2454 AGIDGVILYSL--GTSSPFFSVNKTNG 2478



 Score =  156 bits (395), Expect = 3e-37
 Identities = 231/923 (25%), Positives = 357/923 (38%), Gaps = 135/923 (14%)

Query: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-----AQDRFLIHLVTGVIRVGNATIDR 2134
            EN  P     +VTA+D DSGL G + Y +  G     A   F I    G I V    IDR
Sbjct: 69   ENAKP-VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDR 126

Query: 2135 EEQ-------------ESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
            E               +  R+T +A  +G   LS  A V + ++D+ND+ P F       
Sbjct: 127  ERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVT 184

Query: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVP-NQEDAFAVNINTG-- 2238
            S+ +  +PGT I N+ A D D        I G VA +    L+P N    F ++  TG  
Sbjct: 185  SISDETQPGTEIINVLATDQDSG------IYGTVAYE----LIPGNVSSLFTIDSTTGLY 234

Query: 2239 --SVMVKSPMN----RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
               V + S +N    +E++ + E+ L ++ +   + ER       K   +         +
Sbjct: 235  SPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKV-ERDEEAAEKKFEAS----RGWFMR 289

Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAG 2352
            FK     +Y++   E A+      A    +  K L   + Y  L L              
Sbjct: 290  FKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPL-------------- 335

Query: 2353 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
                     + E   L+  V A D G         V + I         F++P Y   V+
Sbjct: 336  --------SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387

Query: 2413 EDVPVGTIILTVTATD-ADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHY 2471
            EDVP  + I TV A +  +S        S GD   KF+I+P  G I     LD E +   
Sbjct: 388  EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 447

Query: 2472 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 2531
            +LT  A+       S     S +V I V+DVND  P F +      + +  P GT++   
Sbjct: 448  VLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 502

Query: 2532 MATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYE--KFSLTVVATDGGEP 2589
             A D+D G NG + YS+  P    F +D   G++     L + E  + +LT+ A D G  
Sbjct: 503  RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 562

Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD-KDEGLNGAV 2648
            P     ++L  VI+  ++ P +        + + E +   + + +  A     +     +
Sbjct: 563  P-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 621

Query: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPL 2708
            RYS   +    D   F I P +G I   ++ D ES   Y+  + A              +
Sbjct: 622  RYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTV 678

Query: 2709 QVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
             V + D +DN P F+           L V E      ++G +T A+D D G N  + YF+
Sbjct: 679  IVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGKIT-AIDMDSGKNGQLLYFL 731

Query: 2769 AAGNE--EKNFHLQPDGCLLVL-----------RDLDREREAIFSFIVKA-------SSN 2808
             +  +  + N +  P G + V+            D     + + +F++K+          
Sbjct: 732  LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791

Query: 2809 RSWT----PPRGPSPTLDLVADL------TLQEVRVVLEDINDQPPRFTKA----EYTAG 2854
             +W       RG      LV D           V V + DIND  P F +     E    
Sbjct: 792  INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851

Query: 2855 VATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
            V     V   +  V A D D GNN+ V YS+            SED    F + + +G +
Sbjct: 852  VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV-----------SSEDSSDHFKIDANNGEI 900

Query: 2915 RTFD-LFMAYSPGYFVVDIVARD 2936
            RT   L   Y P Y  + ++A D
Sbjct: 901  RTTTILSYDYRPSY-RMSVIATD 922



 Score =  142 bits (358), Expect = 6e-33
 Identities = 141/518 (27%), Positives = 239/518 (46%), Gaps = 46/518 (8%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVV 87
            P F+  F+   + + E  PVG SV  L A D++ N+ + + +    +S+ F+++P  G +
Sbjct: 1990 PVFSQDFYQ--VTVPESIPVGYSVLTLSATDLESNENISYRILS--SSKEFSIDPKNGTI 2045

Query: 88   WLRQP---LDRETKSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
            +   P   LD  + ++F VE S   +  +     V I + D+N+ AP F  + Y++ + E
Sbjct: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105

Query: 144  NTPVGTPIFIVNATDPDLGA----------GGSVLYSFQPPSQFFAID---SARGIVTVI 190
            +  VG+ +   +  D D              G+   +F   ++FF  +      G + ++
Sbjct: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165

Query: 191  RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
              LD E + +++L + A+D     PLS+ A ++I + DV D  P F +L Y T++ E +P
Sbjct: 2166 HSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224

Query: 251  PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
             G+ + +++A D+D G    I Y I+SGN    F L+  +GVL L   LD E       F
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK---MTKF 2281

Query: 311  ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
             LTV+ +    D      +    F + V+D ND+AP+F  S +S  + E   +   +   
Sbjct: 2282 TLTVQAS----DAEKKHFSFAVVF-VSVLDDNDHAPQFMFSSFSCIVPENLPISSTI-CS 2335

Query: 371  IQVVDKDE----NLGLNSMFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYET 423
            I  +D D      L  + +   +L    S+    F+I P +     DI  +    LDYE 
Sbjct: 2336 INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLT----GDIHAKQI--LDYEN 2389

Query: 424  VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
             ++Y   + A +   D      V + +   ++  PIF+Q  Y  +L E       +  V 
Sbjct: 2390 GNKYCLTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVE 2448

Query: 484  ATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARL 521
            A+D DAG  G + Y        FS++K  G I LI  L
Sbjct: 2449 ASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486



 Score = 72.4 bits (176), Expect = 7e-12
 Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 18/156 (11%)

Query: 154 VNATDPDLGAGGSVLYS-------FQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTV 205
           V A+D D G  G + YS       ++ P Q F ID   G + V +++D E   A Y L V
Sbjct: 79  VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 206 NATDQDKTRP---------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
            A D D+ R          LS  A + + + DV D  P+F    Y T+I + + PGT + 
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197

Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV 292
            + A DQD G    + Y ++ GN +S+F +D  +G+
Sbjct: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 50/157 (31%), Positives = 69/157 (43%), Gaps = 23/157 (14%)

Query: 53  TQLLAQDMDNDPLVF-------GVSGEEASRFFAVEPDTGVVWLRQPLDRETKS---EFT 102
           T++ A D D+    F       G    EA + F ++P  G + + Q +DRE      +  
Sbjct: 77  TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136

Query: 103 VEFSVSDHQ---------GVITRK--VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
           VE    D Q         G ++ +  V + + DVNDN P F+   Y   I + T  GT I
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196

Query: 152 FIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGI 186
             V ATD D G  G+V Y   P   S  F IDS  G+
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 59/200 (29%), Positives = 90/200 (45%), Gaps = 30/200 (15%)

Query: 2727 KGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAG----NEEKNF 2777
            +GSP+ +L         E + +      VT A DAD G    + Y +  G       + F
Sbjct: 51   RGSPETELWGAIVFRSQEENAKPVKETEVT-ASDADSGLYGFIEYSLYDGFLSYEAPQAF 109

Query: 2778 HLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPPRGPSPTLDLV-ADLTLQE-VR 2833
             + P DG + V +D+DRER+ A +  +V+A               L LV   L+ Q  VR
Sbjct: 110  RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTH-----LALVKGGLSAQAFVR 164

Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRA 2893
            V LED+ND  P F  + Y   ++ + + G+E+I VLA D D G    V Y ++       
Sbjct: 165  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI------- 217

Query: 2894 LANDSEDVGQVFTMGSMDGI 2913
                  +V  +FT+ S  G+
Sbjct: 218  ----PGNVSSLFTIDSTTGL 233



 Score = 40.0 bits (92), Expect = 0.039
 Identities = 44/173 (25%), Positives = 76/173 (43%), Gaps = 35/173 (20%)

Query: 584 RATDEDSPP--NNQITYSIVSASAFGSYFDISLYEGY---------------GVISVSRP 626
           R+ +E++ P    ++T S   +  +G + + SLY+G+               G I VS+ 
Sbjct: 65  RSQEENAKPVKETEVTASDADSGLYG-FIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123

Query: 627 LDYEQISNGLIYLTVMAMDAGNPP----------LNSTVPVTIEVFDENDNPPTFSKPAY 676
           +D E+       L V A D               L++   V +++ D NDN P F+   Y
Sbjct: 124 IDRER-DPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182

Query: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL---EGSTQFRINARSG 726
             S+ +    G  ++ + ATD D S  YG  ++ Y L     S+ F I++ +G
Sbjct: 183 VTSISDETQPGTEIINVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTG 232


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score =  444 bits (1142), Expect = e-124
 Identities = 341/980 (34%), Positives = 487/980 (49%), Gaps = 53/980 (5%)

Query: 1100 PIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI--LHGNHGNNF-RIHVSN 1156
            P F   SY+A+VPE+ P G  +  L+A D DEGE GR+ Y +  L  +  N F  +    
Sbjct: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238

Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSR 1215
            G +      LDRE  S+HV  V A +H + P RS++  + + V D ND  PVF QQ+Y  
Sbjct: 239  GAVTTAEE-LDRETKSTHVFRVTAQDHGM-PRRSALATLTILVTDTNDHDPVFEQQEYKE 296

Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK----FEIDESTGLIITVNYL 1271
              LRE   +G  V+ V+ATD D+     + YR+L G+ G     FEID  +G+I T   +
Sbjct: 297  -SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355

Query: 1272 DYETKTSYMMNVSATDQA--PPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALG 1329
            D E   SY + V A+DQ   P       +V++++ ++ D A QFS   Y   + E++  G
Sbjct: 356  DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415

Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
              ++RV A   D  +     ++   S  A+  F +DA TG + V   +D E    YTL V
Sbjct: 416  APVLRVTASDRDKGSNAVVHYSIM-SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474

Query: 1390 VADDGGPKVDSTVKVYITV--LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
             A DGG    S V   +TV  LD NDN+P F  T   A ++ E  P+G  V  V+A D D
Sbjct: 475  RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA-TVLESVPLGYLVLHVQAIDAD 533

Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
            AG N ++ + LA       F   T N+  G + VA  LDREE+D Y   V A D GTP  
Sbjct: 534  AGDNARLEYRLAGVGHDFPF---TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590

Query: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567
                 + VT+LD+NDN P    P  Y V +NE+   GT+VV V A DRD   +SV++Y I
Sbjct: 591  TASASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647

Query: 1568 TEGNKDMAFRMDRISGE-IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626
            T GN    F +   SG  + +   P D + +  Y L  T  D    T   T  + V + D
Sbjct: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTD 704

Query: 1627 ENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRID 1686
             N + P+FQ  HY V ++E      T+++ I A D D G N  +TY +   + +  FRID
Sbjct: 705  ANTHRPVFQSSHYTVNVNEDRPA-GTTVVLISATDEDTGENARITYFME--DSIPQFRID 761

Query: 1687 RHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR 1746
               G +T   ELDYE     YTL +TA D       + + TT + + VND+NDN P F R
Sbjct: 762  ADTGAVTTQAELDYE-DQVSYTLAITARDNG---IPQKSDTTYLEILVNDVNDNAPQFLR 817

Query: 1747 D-YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVR 1804
            D Y+G     +  P   V    A DRDSG NG+V Y+   GD   G+F++    G++R  
Sbjct: 818  DSYQGSV-YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876

Query: 1805 KDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS 1864
            +   LDRE +A Y L   A D+GMPP  + M V + VLD+NDN PV      ++ + ENS
Sbjct: 877  R--RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934

Query: 1865 PVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKL 1924
            P+   VA V A+D D G NA++ + I  GN    F ++  +G +T    LD E  PEY L
Sbjct: 935  PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994

Query: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984
             I     P   R        + + L D NDN P+         +  N       +   G 
Sbjct: 995  VIQATSAPLVSRAT------VHVRLLDRNDNPPVLGNFEI---LFNNYVTNRSSSFPGGA 1045

Query: 1985 ILALDA-DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLL 2042
            I  + A D DI   +TY    G +  L  +N+STG + +   +  +R       +  +L+
Sbjct: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPL---EAIMSVLV 1102

Query: 2043 AEDIGLLNSTAHLLITILDD 2062
            ++ +  + +   L +TI+ D
Sbjct: 1103 SDGVHSVTAQCALRVTIITD 1122



 Score =  405 bits (1041), Expect = e-112
 Identities = 312/908 (34%), Positives = 457/908 (50%), Gaps = 85/908 (9%)

Query: 1957 PLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ---LLGAQSG-LFDI 2012
            P F   +YQA V EN PAGTP+  L     A+D D+     + Y    L  ++S   F +
Sbjct: 179  PQFQPPSYQATVPENQPAGTPVASLR----AIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234

Query: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFS 2070
            +  TG VT      +DRE  S  +  +   A+D G+   +A   +TIL  D ND+ P F 
Sbjct: 235  DPVTGAVTTAEE--LDRETKSTHVFRVT--AQDHGMPRRSALATLTILVTDTNDHDPVFE 290

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA----QDRFLIHLVTGVIR 2126
                   L EN   G+ VL V ATD D+  N  ++YR+  G+     + F I   +GVIR
Sbjct: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350

Query: 2127 VGNATIDREEQESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVL 2184
                 +DREE ESY+LTV A+D+G  P   S TA V + ++D ND+ P+F      V V 
Sbjct: 351  T-RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409

Query: 2185 ESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
            E   PG  +  +TA D D   N  + Y I+             N    F ++  TG++ V
Sbjct: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-----------GNARGQFYLDAQTGALDV 458

Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
             SP++ E   T E TL V   A D     +S  +  +TV VLD+NDN P F     T + 
Sbjct: 459  VSPLDYE--TTKEYTLRV--RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS---TPFQ 511

Query: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
              +LE    G  ++ V A+D D G N  + Y L   V   +    ++  G +     +D 
Sbjct: 512  ATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG-VGHDFPFTINNGTGWISVAAELDR 570

Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL 2422
            EEV + +F V A D+G+P   A   V + ++D+NDNNP F QP Y   + ED  VGT ++
Sbjct: 571  EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630

Query: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYILTALAKDN 2480
            TV+A D D+ +    + + G+  ++F+I   +G   + +   LD + +  Y+L   A D 
Sbjct: 631  TVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD- 689

Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
                    R+++ Q+V+ V D N  RP F    ++ +V E+ PAGT+V+ + ATD+D G 
Sbjct: 690  ------GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE 743

Query: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLL 2598
            N  +TY +E   +  F +D D+G VTTQ  L  +    ++L + A D G P    TT L 
Sbjct: 744  NARITYFME-DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE 802

Query: 2599 VEVIDVNDNRPVFVRPP-NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAG 2657
            + V DVNDN P F+R    G++    E++P  ++V ++ ATD+D GLNG V Y+F    G
Sbjct: 803  ILVNDVNDNAPQFLRDSYQGSVY---EDVPPFTSVLQISATDRDSGLNGRVFYTF--QGG 857

Query: 2658 NRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDD 2717
            +     FI++  SG+++T +RLDRE+ A Y L   A D G P P  T   + V + D++D
Sbjct: 858  DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPMEVTVTVLDVND 916

Query: 2718 NEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNF 2777
            N P+F +      ++ +  V E+SP G  V  VT A D DEG NA + Y I  GN  + F
Sbjct: 917  NPPVFEQ-----DEFDVF-VEENSPIGLAVARVT-ATDPDEGTNAQIMYQIVEGNIPEVF 969

Query: 2778 HLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVL 2836
             L    G L  L DLD E    +  +++A+S               LV+  T   V V L
Sbjct: 970  QLDIFSGELTALVDLDYEDRPEYVLVIQATS-------------APLVSRAT---VHVRL 1013

Query: 2837 EDINDQPP 2844
             D ND PP
Sbjct: 1014 LDRNDNPP 1021



 Score =  392 bits (1007), Expect = e-108
 Identities = 304/974 (31%), Positives = 462/974 (47%), Gaps = 62/974 (6%)

Query: 1530 PFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT---EGNKDMAFRMDRISGEIA 1586
            P  Y  +V EN   GT V  +RA D D G    L Y +    +   +  F +D ++G + 
Sbjct: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVT 242

Query: 1587 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646
            T     DRE +S +    T +D G P  SA   + + + D ND+ P+F+Q  Y+  L E 
Sbjct: 243  TAEEL-DRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301

Query: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAIV---AGNIVNTFRIDRHMGVITAAKELDYEIS 1703
             + +   ++T++A D D  PN  + Y ++    G+    F ID   GVI     +D E  
Sbjct: 302  LE-VGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360

Query: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
               Y L V A+DQ      R T T  V ++V D NDN P F           +  PG  V
Sbjct: 361  ES-YQLTVEASDQGRDPGPRST-TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418

Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
                A DRD G N  V YSIM G+  G+F +    G L V     LD ET   Y L + A
Sbjct: 419  LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYETTKEYTLRVRA 476

Query: 1824 RDRGMPPLSSTM-LVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
            +D G PPLS+   LV ++VLDINDN P+ ++ P   T+ E+ P+   V HV A DAD+G 
Sbjct: 477  QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536

Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
            NARL + +     +  F IN  TG ++V   LDRE +  Y   +  +D+      A    
Sbjct: 537  NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
             + ++   D NDN+P FT+  Y   + E++  GT +  ++        D+D ++V+TYQ+
Sbjct: 597  SVTVL---DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA------VDRDAHSVITYQI 647

Query: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061
              G     F I S +G   V   + +D +     +L +   A D G    TA +++ + D
Sbjct: 648  TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT--ASD-GTRQDTAQIVVNVTD 704

Query: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLV 2121
             N +RP F  +  TV++ E+ P G +V+ ++ATDED+G N  + Y +E     +F I   
Sbjct: 705  ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDAD 763

Query: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
            TG +    A +D E+Q SY L + A D G    S T  + IL++D+ND+ P+FL      
Sbjct: 764  TGAVTT-QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822

Query: 2182 SVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
            SV E   P T +  I+A D D  LN ++ Y   G    DD D         F V   +G 
Sbjct: 823  SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG---GDDGD-------GDFIVESTSGI 872

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            V     ++RE VA Y +    +D     P R+      ++TV VLDVNDN P F+     
Sbjct: 873  VRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPM----EVTVTVLDVNDNPPVFEQDEFD 927

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
             ++E   E +  G  +  V A DPD+G N  + Y +++   P   QL D  +G++ A   
Sbjct: 928  VFVE---ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQL-DIFSGELTALVD 983

Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV-- 2417
            +DYE+       ++A+   S P  +   V++ ++D NDN P+       E +F +     
Sbjct: 984  LDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN---FEILFNNYVTNR 1037

Query: 2418 -----GTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
                 G  I  V A D D  +     +  G+  S   +N +TG++ +  +LD  +    I
Sbjct: 1038 SSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAI 1097

Query: 2473 LTALAKDNPGDVAS 2486
            ++ L  D    V +
Sbjct: 1098 MSVLVSDGVHSVTA 1111



 Score =  390 bits (1001), Expect = e-107
 Identities = 316/996 (31%), Positives = 469/996 (47%), Gaps = 58/996 (5%)

Query: 541  EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600
            E   GR + NV    +  P FQ  +Y   + EN+P+ T +  LRA D D     ++ Y++
Sbjct: 165  ESLGGRRKRNV----NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM 220

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
             +     S    SL    G ++ +  LD E  S  +  +T  A D G P  ++   +TI 
Sbjct: 221  DALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVT--AQDHGMPRRSALATLTIL 278

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGS--- 716
            V D ND+ P F +  Y  S+ EN+  G  VL + ATD D        +I+Y L EGS   
Sbjct: 279  VTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPN---ANILYRLLEGSGGS 335

Query: 717  --TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDN 774
                F I+ RSG I T   +DRE    Y L V A D G     ++  A V +++ D NDN
Sbjct: 336  PSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN 395

Query: 775  HPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTG 831
             P + +  Y + + E   P + V  V A D D G N  + YSI   N   +FY L++ TG
Sbjct: 396  APQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTG 454

Query: 832  KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
                    LD  +P  +E      + V   D GRPPL +  S  V V +LD+NDN P F 
Sbjct: 455  A-------LDVVSPLDYETTKEYTLRVRAQDGGRPPL-SNVSGLVTVQVLDINDNAPIFV 506

Query: 892  NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951
            + PF A VLE +P G  +  V AID D G N  + YR+        F IN+ +G +    
Sbjct: 507  STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA 566

Query: 952  ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011
            ELDRE +  Y   V A D GTP  ++++++++ VLDVND  PTF    Y V ++ED    
Sbjct: 567  ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG 626

Query: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRD--AVVRTVVGLDRETTAAYMLI 1069
              VV ++  D D   ++ ++Y IT GN   +FS+  +    +V   + LD +    Y+L 
Sbjct: 627  TSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684

Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
            + A D    G R   TA + V V D N +RP+F  S Y  +V ED P G +++ + ATD 
Sbjct: 685  VTASD----GTRQ-DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDE 739

Query: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR 1189
            D GE  R+ Y     +    FRI    G +      LD E   S+ L + A ++ +    
Sbjct: 740  DTGENARITY--FMEDSIPQFRIDADTGAVTT-QAELDYEDQVSYTLAITARDNGIPQKS 796

Query: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249
             +  + + V D+ND AP F +  Y    + E     TSV+ + ATDRDSG  G V Y   
Sbjct: 797  DTTYLEILVNDVNDNAPQFLRDSYQG-SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855

Query: 1250 SG--AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
             G   +G F ++ ++G++ T+  LD E    Y++   A D+  P  +    V +T+L+  
Sbjct: 856  GGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVN 915

Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKALFKID 1365
            D    F    ++  + EN  +G  + RV A   D     QI Y+           +F++D
Sbjct: 916  DNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI---VEGNIPEVFQLD 972

Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTS 1422
              +G +T    +D E    Y L + A    P V S   V++ +LD NDN P    F+   
Sbjct: 973  IFSGELTALVDLDYEDRPEYVLVIQA-TSAPLV-SRATVHVRLLDRNDNPPVLGNFEILF 1030

Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
            ++ V+       G  +  V A DPD   +  + +S   GN      +V  N S GE+ ++
Sbjct: 1031 NNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFERGN---ELSLVLLNASTGELKLS 1085

Query: 1483 RPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518
            R LD       I+ V+ SD G         L+VTI+
Sbjct: 1086 RALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120



 Score =  388 bits (997), Expect = e-107
 Identities = 306/980 (31%), Positives = 475/980 (48%), Gaps = 79/980 (8%)

Query: 1740 NVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYS---IMDGDPLGEFV 1793
            NV T P+     ++ T  E QP G  V +  A D D G  G++EY+   + D      F 
Sbjct: 174  NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233

Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
            + PV G +   +  ELDRET + +   + A+D GMP  S+   + I V D ND+DPV   
Sbjct: 234  LDPVTGAVTTAE--ELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291

Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGIVTV 1910
                 ++ EN  V   V  V A+D D+  NA + + +   + G+    F I+  +G++  
Sbjct: 292  QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351

Query: 1911 NRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVME 1970
              P+DRE +  Y+LT+   D   +P   R     + + + D+NDN P F++  Y  +V E
Sbjct: 352  RGPVDREEVESYQLTVEASDQGRDPG-PRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRE 410

Query: 1971 NSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDR 2029
            +   G P+      + A D D+   AVV Y ++ G   G F +++ TG + V S   +D 
Sbjct: 411  DVTPGAPVL----RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDY 464

Query: 2030 EAFSPPILELLLLAEDIG---LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086
            E      L +   A+D G   L N +  + + +LD NDN P F        +LE+ P G+
Sbjct: 465  ETTKEYTLRVR--AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522

Query: 2087 SVLQVTATDEDSGLNGELVYRIEAGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
             VL V A D D+G N  L YR+     D  F I+  TG I V  A +DREE + Y   V 
Sbjct: 523  LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVA-AELDREEVDFYSFGVE 581

Query: 2146 ATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP 2205
            A D GT  L+ +A V++ + D+ND+ P F  P  TV + E A  GT +  ++A+D D + 
Sbjct: 582  ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS 641

Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELVATYEVTLSVIDN 2263
             + Y I              N  + F++   +G  +V    P++ +L   Y + ++  D 
Sbjct: 642  VITYQITS-----------GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG 690

Query: 2264 ASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDP 2323
                         A++ VNV D N + P F+    ++Y   + E    GTT++ ++A D 
Sbjct: 691  TRQ--------DTAQIVVNVTDANTHRPVFQS---SHYTVNVNEDRPAGTTVVLISATDE 739

Query: 2324 DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRA 2383
            D G N  +TY + D +P   +   D+  G V     +DYE+       + A DNG P ++
Sbjct: 740  DTGENARITYFMEDSIPQFRI---DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKS 796

Query: 2384 AEIPVYLEIV--DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
                 YLEI+  D+NDN P F + SYQ +V+EDVP  T +L ++ATD DSG    + Y+ 
Sbjct: 797  DT--TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854

Query: 2442 ---GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
                DG+  F +  T+G +  L  LDRE    Y+L A A D     A       ++V + 
Sbjct: 855  QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA----RTPMEVTVT 910

Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFH 2557
            VLDVND  P F + +F   V EN P G +V  + ATD DEG N ++ Y + EG   E F 
Sbjct: 911  VLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQ 970

Query: 2558 VDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
            +D+ SG +T    L  YE     V+       PL     + V ++D NDN PV     N 
Sbjct: 971  LDIFSGELTALVDLD-YEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVL---GNF 1026

Query: 2618 TILHIREEIPLRSNVYEVYATDK----DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
             IL     +  RS+ +   A  +    D  ++ ++ YSF +  GN +    +++  +G +
Sbjct: 1027 EIL-FNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER--GN-ELSLVLLNASTGEL 1082

Query: 2674 QTAQRLD--RESQAVYSLIL 2691
            + ++ LD  R  +A+ S+++
Sbjct: 1083 KLSRALDNNRPLEAIMSVLV 1102



 Score =  388 bits (996), Expect = e-107
 Identities = 316/984 (32%), Positives = 471/984 (47%), Gaps = 78/984 (7%)

Query: 42   ISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95
            + E+ P G+ V  L A D D       +  +  +    +++FF+++P TG V   + LDR
Sbjct: 190  VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249

Query: 96   ETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
            ETKS      +  DH G+  R     + I V D ND+ P F  Q Y   + EN  VG  +
Sbjct: 250  ETKSTHVFRVTAQDH-GMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEV 308

Query: 152  FIVNATDPDLGAGGSVLY-----SFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
              V ATD D     ++LY     S   PS+ F ID   G++     +D E  ++YQLTV 
Sbjct: 309  LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368

Query: 207  ATDQDK-TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
            A+DQ +   P ST A + + + D  D  P F    Y   + E   PG  V  +TA D+DK
Sbjct: 369  ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428

Query: 266  GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
            G    + Y+I+SGN    F LD  +G L +   LD E    +  + L V+     D   P
Sbjct: 429  GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET---TKEYTLRVRA---QDGGRP 482

Query: 326  SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
              + V+    + V+DINDNAP F S+ +   + E   +G+ L L +Q +D D   G N+ 
Sbjct: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY-LVLHVQAIDAD--AGDNAR 539

Query: 386  FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYA 444
             E  L G   H F  +  +  G     I VA  LD E VD Y F + A +   P     A
Sbjct: 540  LEYRLAG-VGHDFPFTINNGTG----WISVAAELDREEVDFYSFGVEARDHGTPALTASA 594

Query: 445  KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD 504
             V +T+++ NDN P F+QP Y + L E+  VGTSV+TV A D DA +         +  +
Sbjct: 595  SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN 654

Query: 505  RFSLDKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQ 562
            RFS+   +  GL+ L   LDY+L +++ L + A DG  ++ T ++ +NV D N + P FQ
Sbjct: 655  RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-TAQIVVNVTDANTHRPVFQ 713

Query: 563  KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVIS 622
               Y   + E+ P+ T +V + ATDED+  N +ITY +       S     +    G ++
Sbjct: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-----SIPQFRIDADTGAVT 768

Query: 623  VSRPLDYE-QISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
                LDYE Q+S     L + A D G P  + T  + I V D NDN P F + +Y  SV 
Sbjct: 769  TQAELDYEDQVS---YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825

Query: 682  ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSLLDRE 737
            E++    +VL ++ATD D         + Y+ +G       F + + SG + T   LDRE
Sbjct: 826  EDVPPFTSVLQISATDRDSGL---NGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882

Query: 738  TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797
              ++Y+L   AVD G+   +      V +T+LD+NDN P ++   + + + E +P    V
Sbjct: 883  NVAQYVLRAYAVDKGMPPARTP--MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940

Query: 798  TTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
              V A DPD G N  ++Y I   N  + + L+  +G++    A++D +  D  E  L   
Sbjct: 941  ARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVDLDYEDRPEYVL--- 994

Query: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----FVAEVLEGIPAGVSIY 910
             V+  T     PL   S ATV V LLD NDN P   N       +V       P G +I 
Sbjct: 995  -VIQATSA---PL--VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIG 1047

Query: 911  QVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDA 970
            +V A D D  ++  ++Y    G      L+N+S+G +  +  LD  R  E  + V+ SD 
Sbjct: 1048 RVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105

Query: 971  GTPTKSSTSTLTIHVLDVNDETPT 994
                 S T+   + V  + DE  T
Sbjct: 1106 ---VHSVTAQCALRVTIITDEMLT 1126



 Score =  385 bits (990), Expect = e-106
 Identities = 312/984 (31%), Positives = 465/984 (47%), Gaps = 57/984 (5%)

Query: 343  DNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG--LNSMFEVYLVGNNSHHFII 400
            + AP+F    Y   + E    G  +   ++ +D DE     L    +      ++  F +
Sbjct: 176  NTAPQFQPPSYQATVPENQPAGTPVAS-LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234

Query: 401  SPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPI 459
             P +        +  A  LD ET   + F + A +  +P     A + I + + ND+ P+
Sbjct: 235  DPVTGA------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288

Query: 460  FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLDKDTGL 514
            F Q  Y  SL EN+ VG  VLTV ATD DA     + Y           + F +D  +G+
Sbjct: 289  FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348

Query: 515  IMLIARLDYELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570
            I     +D E ++ + LT+ A    RD G   TT  V ++V D NDN P F +  YV  +
Sbjct: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408

Query: 571  RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630
            RE+      ++R+ A+D D   N  + YSI+S +A G ++   L    G + V  PLDYE
Sbjct: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY---LDAQTGALDVVSPLDYE 465

Query: 631  QISNGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
                    L V A D G PPL N +  VT++V D NDN P F    +  +V+E++  G  
Sbjct: 466  TTKE--YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523

Query: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749
            VL + A D D       E  +  +     F IN  +G I+  + LDRE    Y   V A 
Sbjct: 524  VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583

Query: 750  DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE 809
            D G      T  A+V++T+LD+NDN+PT+    Y + L E     + V TV AVD D   
Sbjct: 584  DHGT--PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--A 639

Query: 810  NGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
            +  + Y I   N    +S+ S +G    + A+       P + +L R+ V++VT      
Sbjct: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLAL-------PLDYKLERQYVLAVTASDG-- 690

Query: 868  LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
                 +A + VN+ D N + P FQ+  +   V E  PAG ++  + A D D G N  ++Y
Sbjct: 691  -TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749

Query: 928  RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987
             M   +P+  F I++ +G V T  ELD E    Y L + A D G P KS T+ L I V D
Sbjct: 750  FMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVND 807

Query: 988  VNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGG-NVDGKFSVG 1046
            VND  P F    Y  SV EDVP    V+ ++ TD D GLN  + Y   GG + DG F V 
Sbjct: 808  VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVE 867

Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
                +VRT+  LDRE  A Y+L   A+D G    R     T  VTVLDVNDN P+F Q  
Sbjct: 868  STSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT--VTVLDVNDNPPVFEQDE 925

Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
            ++  V E+ P G ++ ++ ATD DEG   ++ Y+I+ GN    F++ + +G L      L
Sbjct: 926  FDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDL 984

Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY---SRLGLRETAG 1223
            D E    +VL+++A +    P+ S   V V + D ND  PV    +    + +  R ++ 
Sbjct: 985  DYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSF 1041

Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMN 1282
             G ++  V A D D  D   + Y    G E     ++ STG +     LD       +M+
Sbjct: 1042 PGGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMS 1099

Query: 1283 VSATDQAPPFNQGFCSVYITLLNE 1306
            V  +D         C++ +T++ +
Sbjct: 1100 VLVSDGVHSVT-AQCALRVTIITD 1122



 Score =  370 bits (949), Expect = e-101
 Identities = 291/898 (32%), Positives = 432/898 (48%), Gaps = 65/898 (7%)

Query: 127  DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP-----PSQFFAID 181
            + AP F    Y   +PEN P GTP+  + A DPD G  G + Y+         +QFF++D
Sbjct: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235

Query: 182  SARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPY 241
               G VT   ELD ET   +   V A D    R  S LA L I++TD  D DP+F    Y
Sbjct: 236  PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPR-RSALATLTILVTDTNDHDPVFEQQEY 294

Query: 242  STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS---IFALDYISGVLTLNGL 298
              ++ E+   G  V  + A D D      I Y ++ G+  S   +F +D  SGV+   G 
Sbjct: 295  KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354

Query: 299  LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAIT 358
            +DRE       + LTV+ ++    R P   + T    + V D NDNAP+F+   Y V + 
Sbjct: 355  VDREE---VESYQLTVEASD--QGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409

Query: 359  ELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAI 417
            E    G  +   ++V   D + G N++    ++ GN    F +   +  G  D    V  
Sbjct: 410  EDVTPGAPV---LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALD----VVS 460

Query: 418  PLDYETVDRYDFDLFANESVPDHVGYAK--VKITLINENDNRPIFSQPLYNISLYENVTV 475
            PLDYET   Y   + A +     +      V + +++ NDN PIF    +  ++ E+V +
Sbjct: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520

Query: 476  GTSVLTVLATDNDAGTFGEVSYFFS----DDPDRFSLDKDTGLIMLIARLDYELIQRFTL 531
            G  VL V A D DAG    + Y  +    D P  F+++  TG I + A LD E +  ++ 
Sbjct: 521  GYLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSF 578

Query: 532  TIIARDGGGEETT--GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
             + ARD G    T    V + VLDVNDN PTF +  Y   L E+    T +V + A D D
Sbjct: 579  GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638

Query: 590  SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP 649
            +  ++ ITY I S +   + F I+   G G++S++ PLDY+     L    V+A+ A + 
Sbjct: 639  A--HSVITYQITSGNT-RNRFSITSQSGGGLVSLALPLDYK-----LERQYVLAVTASDG 690

Query: 650  PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI 709
                T  + + V D N + P F    Y V+V E+  AG TV+ ++ATD D         I
Sbjct: 691  TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE---NARI 747

Query: 710  IYSLEGS-TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITL 768
             Y +E S  QFRI+A +G +TT + LD E +  Y L + A D G+   QK+    + I +
Sbjct: 748  TYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI--PQKSDTTYLEILV 805

Query: 769  LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---PPNKFYS 825
             D+NDN P +    Y  ++ E  PP + V  + A D D G NG + Y+ Q     +  + 
Sbjct: 806  NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865

Query: 826  LNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
            + ST+G +RT    LDREN   +   ++R   V   D G PP +     TV V  LD+ND
Sbjct: 866  VESTSGIVRTLR-RLDRENVAQY---VLRAYAV---DKGMPPARTPMEVTVTV--LDVND 916

Query: 886  NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 945
            N P F+   F   V E  P G+++ +V A D DEG N  + Y++  G     F ++  SG
Sbjct: 917  NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSG 976

Query: 946  VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1001
             +    +LD E   EY L + A+ A      S +T+ + +LD ND  P    F  ++N
Sbjct: 977  ELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFN 1031



 Score =  342 bits (877), Expect = 4e-93
 Identities = 297/982 (30%), Positives = 464/982 (47%), Gaps = 76/982 (7%)

Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRI 1685
            + AP FQ P Y+  + E      T + +++A+D DEG  G + Y   A+        F +
Sbjct: 176  NTAPQFQPPSYQATVPEN-QPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234

Query: 1686 DRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP 1745
            D   G +T A+ELD E +   +   VTA D       R ++  T+ + V D ND+ P F 
Sbjct: 235  DPVTGAVTTAEELDRE-TKSTHVFRVTAQDHG---MPRRSALATLTILVTDTNDHDPVFE 290

Query: 1746 RDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMD---GDPLGEFVISPVEGVLR 1802
            +           + G  V T  A D D+ PN  + Y +++   G P   F I P  GV+R
Sbjct: 291  QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350

Query: 1803 VRKDVELDRETIAFYNLTICARDRGMP--PLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
             R  V  DRE +  Y LT+ A D+G    P S+T  V + V D NDN P        + +
Sbjct: 351  TRGPV--DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408

Query: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920
             E+    + V  V ASD D G NA + ++I +GN    F+++A TG + V  PLD E   
Sbjct: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468

Query: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980
            EY L +  +D    P        L+ + + D NDN P+F  + +QA V+E+ P G    V
Sbjct: 469  EYTLRVRAQDGGRPP--LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG--YLV 524

Query: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
            L+  + A+DAD    A + Y+L G      F IN+ TG ++V +   +DRE         
Sbjct: 525  LH--VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVD--FYSF 578

Query: 2040 LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED 2097
             + A D G   L ++A + +T+LD NDN PTF+    TV L E+   G SV+ V+A D D
Sbjct: 579  GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638

Query: 2098 SGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVATDRGTVPLS 2155
            +  +  + Y+I +G  ++RF I   +G   V  A  +D + +  Y L V A+D GT    
Sbjct: 639  A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GT--RQ 693

Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVG 2213
             TA + + + D N  RP F +   TV+V E    GT +  I+A D D   N ++ Y +  
Sbjct: 694  DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED 753

Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS 2273
             + +             F ++ +TG+V  ++ ++ E   +Y + ++  DN   +P++S  
Sbjct: 754  SIPQ-------------FRIDADTGAVTTQAELDYEDQVSYTLAITARDNG--IPQKS-- 796

Query: 2274 VPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
                 L + V DVNDN PQF       Y   + E   P T+++ ++A D D GLNG V Y
Sbjct: 797  -DTTYLEILVNDVNDNAPQFLR---DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFY 852

Query: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
            T           + +S++G V   R +D E V        A D G PP    + V + ++
Sbjct: 853  TFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912

Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAIN 2451
            D+NDN P+F+Q  +   V E+ P+G  +  VTATD D G  A I Y + +G     F ++
Sbjct: 913  DVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD 972

Query: 2452 PTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK 2511
              +G++  L  LD E +  Y+L   A   P         +   V +++LD ND  P    
Sbjct: 973  IFSGELTALVDLDYEDRPEYVLVIQATSAP-------LVSRATVHVRLLDRNDNPPVLGN 1025

Query: 2512 PQFSTSVYENEPA----GTSVITMMATDQDEGPNGELTYSLE-GPGVEAFHVDMDSGLVT 2566
             +   + Y    +    G ++  + A D D   +  LTYS E G  +    ++  +G + 
Sbjct: 1026 FEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELK 1083

Query: 2567 TQRPLQSYEKFS--LTVVATDG 2586
              R L +       ++V+ +DG
Sbjct: 1084 LSRALDNNRPLEAIMSVLVSDG 1105



 Score =  329 bits (844), Expect = 2e-89
 Identities = 263/836 (31%), Positives = 403/836 (48%), Gaps = 69/836 (8%)

Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVT 2122
            P F P +    + EN P G  V  + A D D G  G L Y ++A    R    F +  VT
Sbjct: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238

Query: 2123 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
            G +      +DRE + ++   V A D G    S  A +TIL+ D ND  P F       S
Sbjct: 239  GAVTTAEE-LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297

Query: 2183 VLESAEPGTVIANITAIDHDLNPKLE--YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2240
            + E+ E G  +  + A D D  P     Y ++        +    +  + F ++  +G +
Sbjct: 298  LRENLEVGYEVLTVRATDGDAPPNANILYRLL--------EGSGGSPSEVFEIDPRSGVI 349

Query: 2241 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
              + P++RE V +Y++T+   D   D   RS +   A + ++V D NDN PQF       
Sbjct: 350  RTRGPVDREEVESYQLTVEASDQGRDPGPRSTT---AAVFLSVEDDNDNAPQFSE---KR 403

Query: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360
            Y+ ++ E  TPG  ++ V A D DKG N +V Y+++     G   L D+  G +     +
Sbjct: 404  YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYL-DAQTGALDVVSPL 462

Query: 2361 DYEEVHWLNFTVRASDNGSPPRA-AEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
            DYE        VRA D G PP +     V ++++DINDN PIF    +Q  V E VP+G 
Sbjct: 463  DYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522

Query: 2420 IILTVTATDADSGNFALIEYSL-GDGES-KFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
            ++L V A DAD+G+ A +EY L G G    F IN  TG I V + LDRE+ D Y     A
Sbjct: 523  LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEA 582

Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
            +D+     +     S  V + VLDVND  P F++P+++  + E+   GTSV+T+ A D+D
Sbjct: 583  RDHGTPALTA----SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638

Query: 2538 EGPNGELTYSL-EGPGVEAFHVDMDSG--LVTTQRPL--QSYEKFSLTVVATDGGEPPLW 2592
               +  +TY +  G     F +   SG  LV+   PL  +   ++ L V A+DG      
Sbjct: 639  A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-- 694

Query: 2593 GTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF 2652
             T  ++V V D N +RPVF    +   +++ E+ P  + V  + ATD+D G N  + Y F
Sbjct: 695  -TAQIVVNVTDANTHRPVF--QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-F 750

Query: 2653 LKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVAL 2712
            ++ +  +    F ID  +G + T   LD E Q  Y+L + A D G P   +T   L++ +
Sbjct: 751  MEDSIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY-LEILV 805

Query: 2713 EDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN 2772
             D++DN P F+R       Y      E  P  T V  ++ A D D G N  V+Y    G+
Sbjct: 806  NDVNDNAPQFLRDSYQGSVY------EDVPPFTSVLQIS-ATDRDSGLNGRVFYTFQGGD 858

Query: 2773 E-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830
            + + +F ++   G +  LR LDRE  A   ++++A +     PP             T  
Sbjct: 859  DGDGDFIVESTSGIVRTLRRLDRENVA--QYVLRAYAVDKGMPPAR-----------TPM 905

Query: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
            EV V + D+ND PP F + E+   V  ++ +G  + +V A D D G N+ + Y I+
Sbjct: 906  EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961



 Score =  258 bits (658), Expect = 9e-68
 Identities = 236/820 (28%), Positives = 368/820 (44%), Gaps = 85/820 (10%)

Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLVPN 2226
            ++ P+F  P    +V E+   GT +A++ AID D     +LEY +         D L  +
Sbjct: 176  NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM---------DALFDS 226

Query: 2227 QEDA-FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
            + +  F+++  TG+V     ++RE  +T+   ++  D+   +P RS     A LT+ V D
Sbjct: 227  RSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHG--MPRRSAL---ATLTILVTD 281

Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLV--PPGY 2343
             ND+ P F+      Y E + E    G  ++ V A D D   N  + Y LL+     P  
Sbjct: 282  TNDHDPVFEQ---QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE 338

Query: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP--PRAAEIPVYLEIVDINDNNPI 2401
            V   D  +G +     VD EEV     TV ASD G    PR+    V+L + D NDN P 
Sbjct: 339  VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398

Query: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYV 2459
            F +  Y   V EDV  G  +L VTA+D D G+ A++ YS+  G+   +F ++  TG + V
Sbjct: 399  FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV 458

Query: 2460 LSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVY 2519
            +S LD E    Y L   A+D      SN    S  V +QVLD+ND  P F    F  +V 
Sbjct: 459  VSPLDYETTKEYTLRVRAQDGGRPPLSN---VSGLVTVQVLDINDNAPIFVSTPFQATVL 515

Query: 2520 ENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEK 2576
            E+ P G  V+ + A D D G N  L Y L G G +  F ++  +G ++    L  +  + 
Sbjct: 516  ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDF 575

Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
            +S  V A D G P L  +  + V V+DVNDN P F +P     + + E+  + ++V  V 
Sbjct: 576  YSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPE--YTVRLNEDAAVGTSVVTVS 633

Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI-SGLIQTAQRLDRESQAVYSLILVASD 2695
            A D+D   +  + Y    T+GN    F I      GL+  A  LD + +  Y L + ASD
Sbjct: 634  AVDRD--AHSVITYQI--TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD 689

Query: 2696 LGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVD 2755
                   +T Q + V + D + + P+F         +  + V E  P GT V  ++ A D
Sbjct: 690  ---GTRQDTAQ-IVVNVTDANTHRPVF------QSSHYTVNVNEDRPAGTTVVLIS-ATD 738

Query: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPP 2814
             D G NA + YF+   +    F +  D G +    +LD E +  ++  + A  N    P 
Sbjct: 739  EDTGENARITYFME--DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDN--GIPQ 794

Query: 2815 RGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDAD 2874
            +  +  L+           +++ D+ND  P+F +  Y   V  D    + ++Q+ A D D
Sbjct: 795  KSDTTYLE-----------ILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843

Query: 2875 IGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVA 2934
             G N  VFY+              +D    F + S  GI+RT       +   +V+   A
Sbjct: 844  SGLNGRVFYTF----------QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893

Query: 2935 RDLAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEE 2974
             D          G+   R    V + + ++ D    FE++
Sbjct: 894  VDK---------GMPPARTPMEVTVTVLDVNDNPPVFEQD 924



 Score =  181 bits (459), Expect = 1e-44
 Identities = 152/572 (26%), Positives = 260/572 (45%), Gaps = 34/572 (5%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRF-FAVEPDTGVVWLRQPLDRETK 98
            ++ED  VG+SV  + A D D   ++     SG   +RF    +   G+V L  PLD + +
Sbjct: 619  LNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678

Query: 99   SEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATD 158
             ++ +  + SD     T ++ + V D N + P F +  Y+V + E+ P GT + +++ATD
Sbjct: 679  RQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738

Query: 159  PDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
             D G    + Y  +     F ID+  G VT   ELDYE   +Y L + A D    +   T
Sbjct: 739  EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798

Query: 219  LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
               L I++ DV D  P F+   Y  ++YE  PP T+V  I+A D+D G    + YT   G
Sbjct: 799  -TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGG 857

Query: 279  NT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE--LNDDRTPSDATVTTTFN 335
            +  +  F ++  SG++     LDREN      ++L     +  +   RTP + TVT    
Sbjct: 858  DDGDGDFIVESTSGIVRTLRRLDRENVAQ---YVLRAYAVDKGMPPARTPMEVTVT---- 910

Query: 336  ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
              V+D+NDN P F   E+ V + E + +G A+   +   D DE      M+++ + GN  
Sbjct: 911  --VLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR-VTATDPDEGTNAQIMYQI-VEGNIP 966

Query: 396  HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455
              F +   S +      +   + LDYE  DR ++ L    +    V  A V + L++ ND
Sbjct: 967  EVFQLDIFSGE------LTALVDLDYE--DRPEYVLVIQATSAPLVSRATVHVRLLDRND 1018

Query: 456  NRPIFS--QPLYN--ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
            N P+    + L+N  ++   +   G ++  V A D D       S+   ++     L+  
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078

Query: 512  TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL- 570
            TG + L   LD        ++++  D G    T +  + V  + D + T      +  + 
Sbjct: 1079 TGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIITDEMLTHSITLRLEDMS 1137

Query: 571  --RENEPSVTQLVRLRATDEDSPPNNQITYSI 600
              R   P +   ++  A    +PP++ + +++
Sbjct: 1138 PERFLSPLLGLFIQAVAATLATPPDHVVVFNV 1169


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score =  413 bits (1062), Expect = e-114
 Identities = 329/1008 (32%), Positives = 496/1008 (49%), Gaps = 67/1008 (6%)

Query: 899  VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM----PRMDFLINSSSGVVVTTTELD 954
            + E  PAG  I Q+ A    EG    VSY M  G+     R  F I+S++G V T + LD
Sbjct: 254  LFENEPAGTLILQLHAHYTIEGEEERVSYYME-GLFDERSRGYFRIDSATGAVSTDSVLD 312

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    + LRV A D  TP +S+T+ +T+ V D ND +P F  + Y   V E++   + V
Sbjct: 313  RETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEV 372

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAID 1074
            + +  +D D  +NA L Y + GG  D  F +     VV T   LDRE  A Y L++EA D
Sbjct: 373  LTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431

Query: 1075 NGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF 1134
             G      + TATV++ V D NDN P F + +Y   VPED+    ++L+++ATD D+G+ 
Sbjct: 432  QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491

Query: 1135 GRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRV 1194
              + Y IL GN    F +H  +G+L     PLD E    + L ++A +    P+ +S  V
Sbjct: 492  AAIHYSILSGNVAGQFYLHSLSGIL-DVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550

Query: 1195 I-VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA- 1252
            + V V D+ND  P+F    +    L E   +G  V+ +QA D DSG+   ++YR++  A 
Sbjct: 551  VSVQVLDVNDNEPIFVSSPFQATVL-ENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609

Query: 1253 -----------------EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1295
                             +  F+I  S+G I     LD E    Y   V A D   P    
Sbjct: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669

Query: 1296 FCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355
              SV IT+L+  D    F+  +YE  + E+ A+G+ ++ +QA   D  + ITY+     +
Sbjct: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG-GN 728

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNS 1415
            T+ +         G+IT+   +D ++   Y L V A DG      T  V I V D N + 
Sbjct: 729  TRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG--TRSHTAHVLINVTDANTHR 786

Query: 1416 PRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDS 1475
            P F  +S   VS+ ED PVG  +AT+ A D D G N ++ + +   +    F I   +  
Sbjct: 787  PVFQ-SSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRI---DPD 840

Query: 1476 IGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNV 1535
             G ++    LD E    Y L ++A D G P +     L++ ILD NDN P     F Y  
Sbjct: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDF-YQG 899

Query: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNK-DMAFRMDRISGEIATRPAPPDR 1594
            S+ E+    T+++QV ATDRD G N  L Y    G+  D  F ++  SG I T+    DR
Sbjct: 900  SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ-RRLDR 958

Query: 1595 ERQSFYHLVATVEDEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTS 1653
            E  + Y+L A   D G+PT LSA+  + VTI+D NDNAPMF++   E+ ++E  + + + 
Sbjct: 959  ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN-NPVGSV 1017

Query: 1654 LITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1713
            +  I+A D DEGPN  + Y IV G++ + F++D   G + A  ELD+E+    Y L+V A
Sbjct: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRR-EYVLVVQA 1076

Query: 1714 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF-----EVTEGQPGPRVWTFLA 1768
            T      S  L S  TV + + D NDN P  P D++  F       +   P   +    A
Sbjct: 1077 T------SAPLVSRATVHILLVDQNDNPPVLP-DFQILFNNYVTNKSNSFPTGVIGCIPA 1129

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
            HD D   +  + Y+ + G+ L   ++ P  G L++ +D++ +R   A   +++       
Sbjct: 1130 HDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIH-- 1185

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITIS-ENSPVSSFVAHVLA 1875
               S T    +RV  I D+      L  +IT+  EN     F++ +LA
Sbjct: 1186 ---SVTAFCTLRVTIITDD-----MLTNSITVRLENMSQEKFLSPLLA 1225



 Score =  399 bits (1024), Expect = e-110
 Identities = 293/915 (32%), Positives = 458/915 (50%), Gaps = 89/915 (9%)

Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDINSSTG 2017
            F    YQ  + EN PAGT +  L+     ++ +++  +     L   +S G F I+S+TG
Sbjct: 245  FPMPNYQVALFENEPAGTLILQLHAHY-TIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303

Query: 2018 VVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
             V+  S  ++DRE     +L +  +       ++T ++ + + D ND+ P F  +     
Sbjct: 304  AVSTDS--VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361

Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ 2137
            + EN   G+ VL + A+D DS +N  L YR+  GA D F ++  +GV+    A +DREE 
Sbjct: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVST-RAVLDREEA 420

Query: 2138 ESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN 2195
              Y+L V A D+G  P  LS TA V I ++D ND+ P+F      V V E     T +  
Sbjct: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480

Query: 2196 ITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVAT 2253
            + A D D   N  + Y I           L  N    F ++  +G + V +P++ E V  
Sbjct: 481  VQATDRDQGQNAAIHYSI-----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529

Query: 2254 YEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF--KPFGITYYMERILEGATP 2311
            Y +++   D        S  V    ++V VLDVNDN P F   PF  T     +LE    
Sbjct: 530  YSLSIKAQDGGRPPLINSSGV----VSVQVLDVNDNEPIFVSSPFQAT-----VLENVPL 580

Query: 2312 GTTLIAVAAVDPDKGLNGLVTYTLLDLVP----------------PGYVQLEDSSAGKVI 2355
            G  ++ + AVD D G N  + Y L+D                   P +     +S+G + 
Sbjct: 581  GYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWIT 640

Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
                +D EEV   +F V A D+GSPP ++   V + ++D+NDN+P+F QP+Y+  + ED 
Sbjct: 641  VCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDA 700

Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYIL 2473
             VG+ +LT+ A D D+ +    + + G+  ++FA++   G   I +   LD +++  Y+L
Sbjct: 701  AVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVL 760

Query: 2474 TALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMA 2533
               A D         R ++  V+I V D N  RP F    ++ SV E+ P GTS+ T+ A
Sbjct: 761  AVTASD-------GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813

Query: 2534 TDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPL 2591
             D+D G N  +TY ++ P V  F +D DSG + T   L  ++   ++LT++A D G P  
Sbjct: 814  NDEDTGENARITYVIQDP-VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK 872

Query: 2592 WGTTMLLVEVIDVNDNRPVFVRP-PNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRY 2650
              TT L + ++D NDN P F+     G+I    E+ P  +++ +V ATD+D G NG + Y
Sbjct: 873  SDTTTLEILILDANDNAPQFLWDFYQGSIF---EDAPPSTSILQVSATDRDSGPNGRLLY 929

Query: 2651 SFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQV 2710
            +F +   + D +F+ I+P SG+I+T +RLDRE+ AVY+L  +A D G P P      +QV
Sbjct: 930  TF-QGGDDGDGDFY-IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987

Query: 2711 ALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAA 2770
             + DI+DN P+F +          L V E++P G++V  +  A D DEGPNA + Y I  
Sbjct: 988  TILDINDNAPMFEKDELE------LFVEENNPVGSVVAKIR-ANDPDEGPNAQIMYQIVE 1040

Query: 2771 GNEEKNFHLQ-PDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTL 2829
            G+    F L   +G L  + +LD E    +  +V+A+S               LV+  T 
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS-------------APLVSRAT- 1086

Query: 2830 QEVRVVLEDINDQPP 2844
              V ++L D ND PP
Sbjct: 1087 --VHILLVDQNDNPP 1099



 Score =  387 bits (993), Expect = e-106
 Identities = 298/994 (29%), Positives = 487/994 (48%), Gaps = 73/994 (7%)

Query: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FRINAR 724
            F  P Y V++ EN  AG  +L L+A     + E  +E + Y +EG         FRI++ 
Sbjct: 245  FPMPNYQVALFENEPAGTLILQLHA---HYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301

Query: 725  SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL--DINDNHPTWKDAP 782
            +G ++T S+LDRETK  ++L V+AVD    ++     AT  IT+L  D ND+ P ++ + 
Sbjct: 302  TGAVSTDSVLDRETKETHVLRVKAVD----YSTPPRSATTYITVLVKDTNDHSPVFEQSE 357

Query: 783  YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLD 841
            Y   + E      +V T+ A D D   N  L Y +       + LN ++G + +T A+LD
Sbjct: 358  YRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVV-STRAVLD 416

Query: 842  RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
            RE    ++      ++V   D GR P   +++ATV++ + D NDN P F    +V +V E
Sbjct: 417  REEAAEYQ------LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE 470

Query: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEY 961
             +    ++ +V A D D+G N  + Y +  G     F ++S SG++     LD E + +Y
Sbjct: 471  DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530

Query: 962  QLRVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
             L + A D G P   +S+  +++ VLDVND  P F  + +  +V E+VP  + VV +   
Sbjct: 531  SLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590

Query: 1021 DNDVGLNAELSY--------FITGGNV---------DGKFSVGYRDAVVRTVVGLDRETT 1063
            D D G NA L Y        F+ GG+          D  F +      +     LDRE  
Sbjct: 591  DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650

Query: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
              Y   +EA+D+G      + + +V +TVLDVNDN P+F Q +YE  + ED   G S+L 
Sbjct: 651  EHYSFGVEAVDHG--SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708

Query: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVS-NGLLMRGPRPLDRERNSSHVLIVEAYN 1182
            L+A D D      + Y++  GN  N F +     G L+    PLD ++   +VL V A +
Sbjct: 709  LQARDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766

Query: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242
               G    +  V++ V D N   PVF    Y+ + + E   +GTS+  + A D D+G+  
Sbjct: 767  ---GTRSHTAHVLINVTDANTHRPVFQSSHYT-VSVSEDRPVGTSIATLSANDEDTGENA 822

Query: 1243 LVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
             + Y ++     +F ID  +G + T+  LDYE + +Y + + A D   P      ++ I 
Sbjct: 823  RITY-VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881

Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKA 1360
            +L+  D A QF    Y+ +I E+    T I++V A   D+    ++ Y F          
Sbjct: 882  ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG--GDDGDG 939

Query: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG--PKVDSTVKVYITVLDENDNSPRF 1418
             F I+  +GVI  Q  +DRE    Y L  +A D G    + ++V++ +T+LD NDN+P F
Sbjct: 940  DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999

Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
            +   +  + + E+ PVG  VA ++A DPD G N Q+++ +  G++   F++   N   G+
Sbjct: 1000 E-KDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLN---GD 1055

Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI---ESPFGYNV 1535
            +     LD E    Y+L V A+      R   HIL   ++D NDNPPV+   +  F   V
Sbjct: 1056 LRAMVELDFEVRREYVLVVQATSAPLVSRATVHIL---LVDQNDNPPVLPDFQILFNNYV 1112

Query: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDR 1594
            +   N      +  + A D D  ++  L+Y   +GN+     +D  +GE+  +R    +R
Sbjct: 1113 TNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170

Query: 1595 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
              ++   L+     +G  +++A   + VTI+ ++
Sbjct: 1171 PLEA---LMEVSVSDGIHSVTAFCTLRVTIITDD 1201



 Score =  380 bits (976), Expect = e-104
 Identities = 310/963 (32%), Positives = 474/963 (49%), Gaps = 62/963 (6%)

Query: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG---GNVDGKFSVGYRDAVVRTVV 1056
            Y V++ E+ P    ++ L+      G    +SY++ G       G F +      V T  
Sbjct: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309

Query: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL--DVNDNRPIFLQSSYEASVPED 1114
             LDRET   ++L ++A+D     +    +AT ++TVL  D ND+ P+F QS Y   V E+
Sbjct: 310  VLDRETKETHVLRVKAVDYSTPPR----SATTYITVLVKDTNDHSPVFEQSEYRERVREN 365

Query: 1115 IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1174
            +  G+ +L ++A+D D      + YR+L G   + F+++ S+G++      LDRE  + +
Sbjct: 366  LEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRA-VLDREEAAEY 423

Query: 1175 VLIVEAYNH--DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQ 1232
             L+VEA +   + GP+ ++  V + VED ND  P F++Q Y  + + E  G+ T+V+ VQ
Sbjct: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYV-VQVPEDVGLNTAVLRVQ 482

Query: 1233 ATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA-P 1290
            ATDRD G    ++Y ILSG   G+F +   +G++  +N LD+E    Y +++ A D   P
Sbjct: 483  ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542

Query: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITY 1348
            P       V + +L+  D    F ++ ++A +LEN+ LG  +V +QA   D+    ++ Y
Sbjct: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602

Query: 1349 RFNAYTST--------------QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DD 1393
            R     ST                   F+I   +G ITV   +DRE+ + Y+  V A D 
Sbjct: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662

Query: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
            G P + S+  V ITVLD NDN P F   +   + + ED  VG  V T++A D DA  N  
Sbjct: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYE-LRLNEDAAVGSSVLTLQARDRDA--NSV 719

Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
            + + L  GN    F + +     G + +A PLD ++   Y+L V ASD GT       ++
Sbjct: 720  ITYQLTGGNTRNRFALSSQRGG-GLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLI 777

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
             VT  D N + PV +S   Y VSV+E+   GT++  + A D D G N+ ++Y I +    
Sbjct: 778  NVT--DANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834

Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
              FR+D  SG + T     D E Q  Y L    +D G P  S TT + + I+D NDNAP 
Sbjct: 835  --FRIDPDSGTMYTM-MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891

Query: 1634 FQQPHYE-VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVN-TFRIDRHMGV 1691
            F    Y+  + ++ P +  TS++ + A D D GPNG + Y    G+  +  F I+   GV
Sbjct: 892  FLWDFYQGSIFEDAPPS--TSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949

Query: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751
            I   + LD E +   Y L   A D+       L+++  + V + DINDN P F +D    
Sbjct: 950  IRTQRRLDRE-NVAVYNLWALAVDRGSPTP--LSASVEIQVTILDINDNAPMFEKDELEL 1006

Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
            F       G  V    A+D D GPN Q+ Y I++GD    F +  + G LR    VELD 
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM--VELDF 1064

Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPM----NITISENSPVS 1867
            E    Y L + A      PL S   V I ++D NDN PVL +  +     +T   NS  +
Sbjct: 1065 EVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121

Query: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
              +  + A D D   +   TF    GN  R   ++  TG + ++R LD  R  E  + +S
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF--VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179

Query: 1928 VKD 1930
            V D
Sbjct: 1180 VSD 1182



 Score =  365 bits (938), Expect = e-100
 Identities = 296/968 (30%), Positives = 472/968 (48%), Gaps = 80/968 (8%)

Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----FRMDRISGEIATR 1588
            Y V++ EN   GT ++Q+ A     G    +SYY+ EG  D      FR+D  +G ++T 
Sbjct: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGYFRIDSATGAVST- 307

Query: 1589 PAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPD 1648
             +  DRE +  + L     D  TP  SATT++ V + D ND++P+F+Q  Y   + E  +
Sbjct: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   ++TI+A D D   N  + Y ++ G   + F+++   GV++    LD E +   Y 
Sbjct: 368  -VGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA-AEYQ 424

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD---YEGPFEVTEGQPGPRVWT 1765
            L+V A DQ       L++T TV + V D NDN P F       + P +V       RV  
Sbjct: 425  LLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ- 482

Query: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825
              A DRD G N  + YSI+ G+  G+F +  + G+L V     LD E +  Y+L+I A+D
Sbjct: 483  --ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIKAQD 538

Query: 1826 RGMPPL-SSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884
             G PPL +S+ +V ++VLD+NDN+P+ ++ P   T+ EN P+   V H+ A DADSG NA
Sbjct: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598

Query: 1885 RLTFNI-----------TAGNRERA------FFINATTGIVTVNRPLDRERIPEYKLTIS 1927
            RL + +           +AG +  A      F I+ ++G +TV   LDRE +  Y   + 
Sbjct: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658

Query: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
              D+   P  +     + ++   D NDN P+FT+ TY+  + E++  G+ +  L      
Sbjct: 659  AVDHGSPPMSSSTSVSITVL---DVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA---- 711

Query: 1988 LDADQDIYAVVTYQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDI 2046
               D+D  +V+TYQL G  +   F ++S  G   +   + +D +     +L +   A D 
Sbjct: 712  --RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT--ASD- 766

Query: 2047 GLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106
            G  + TAH+LI + D N +RP F  +  TV + E+ P G S+  ++A DED+G N  + Y
Sbjct: 767  GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY 826

Query: 2107 RIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166
             I+     +F I   +G +      +D E Q +Y LT++A D G    S T  + ILI D
Sbjct: 827  VIQDPVP-QFRIDPDSGTMYT-MMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILD 884

Query: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLV 2224
             ND+ P+FL      S+ E A P T I  ++A D D  P  +L Y   G    DD D   
Sbjct: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG---GDDGD--- 938

Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
                  F +   +G +  +  ++RE VA Y +    +D  S  P  S SV   ++ V +L
Sbjct: 939  ----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP-LSASV---EIQVTIL 990

Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
            D+NDN P F+   +  ++E   E    G+ +  + A DPD+G N  + Y +++     + 
Sbjct: 991  DINDNAPMFEKDELELFVE---ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047

Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
            QL D   G + A   +D+E        V+A+   S P  +   V++ +VD NDN P+   
Sbjct: 1048 QL-DLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPD 1103

Query: 2405 -----PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459
                  +Y        P G +I  + A D D  +     +  G+      ++P TG++ +
Sbjct: 1104 FQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQL 1162

Query: 2460 LSSLDREK 2467
               LD  +
Sbjct: 1163 SRDLDNNR 1170



 Score =  364 bits (935), Expect = e-100
 Identities = 297/974 (30%), Positives = 453/974 (46%), Gaps = 69/974 (7%)

Query: 561  FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
            F    Y  AL ENEP+ T +++L A         +++Y +       S     +    G 
Sbjct: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304

Query: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
            +S    LD E     +  L V A+D   PP ++T  +T+ V D ND+ P F +  Y   V
Sbjct: 305  VSTDSVLDRETKETHV--LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362

Query: 681  VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRET 738
             EN+  G  VL + A+D D        ++ Y + G     F++N  SG ++T ++LDRE 
Sbjct: 363  RENLEVGYEVLTIRASDRDSPI---NANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419

Query: 739  KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT 798
             +EY L+V A D G      +  ATV I + D NDN+P + +  Y + + E    ++ V 
Sbjct: 420  AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479

Query: 799  TVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
             V A D D G+N  + YSI   N   +FY L+S +G       +LD  NP   E      
Sbjct: 480  RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSG-------ILDVINPLDFEDVQKYS 531

Query: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAI 915
            + +   D GRPPL   SS  V V +LD+NDN+P F + PF A VLE +P G  +  + A+
Sbjct: 532  LSIKAQDGGRPPL-INSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590

Query: 916  DLDEGLNGLVSYRM-----------------PVGMPRMDFLINSSSGVVVTTTELDRERI 958
            D D G N  + YR+                 P   P   F I++SSG +    ELDRE +
Sbjct: 591  DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650

Query: 959  AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018
              Y   V A D G+P  SS+++++I VLDVND  P F    Y + ++ED      V+ L 
Sbjct: 651  EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQ 710

Query: 1019 CTDNDVGLNAELSYFITGGNVDGKFSVGYR--DAVVRTVVGLDRETTAAYMLILEAIDNG 1076
              D D   N+ ++Y +TGGN   +F++  +    ++   + LD +    Y+L + A D  
Sbjct: 711  ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG- 767

Query: 1077 PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGR 1136
                  + TA V + V D N +RP+F  S Y  SV ED P G SI  L A D D GE  R
Sbjct: 768  ----TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823

Query: 1137 VWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIV 1196
            + Y I   +    FRI   +G  M     LD E   ++ L + A ++ +     +  + +
Sbjct: 824  ITYVI--QDPVPQFRIDPDSG-TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880

Query: 1197 YVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEG 1254
             + D ND AP F    Y    + E A   TS++ V ATDRDSG  G + Y    G   +G
Sbjct: 881  LILDANDNAPQFLWDFYQG-SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939

Query: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQF 1313
             F I+ ++G+I T   LD E    Y +   A D+  P        + +T+L+  D A  F
Sbjct: 940  DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999

Query: 1314 SNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI 1371
                 E  + EN  +G+ + +++A   D     QI Y+         +  F++D + G +
Sbjct: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQI---VEGDMRHFFQLDLLNGDL 1056

Query: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF-DFT---SDSAVS 1427
                 +D E    Y L V A    P V S   V+I ++D+NDN P   DF    ++   +
Sbjct: 1057 RAMVELDFEVRREYVLVVQA-TSAPLV-SRATVHILLVDQNDNPPVLPDFQILFNNYVTN 1114

Query: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487
                 P G  +  + A DPD   +  + ++   GN      ++  + + GE+ ++R LD 
Sbjct: 1115 KSNSFPTGV-IGCIPAHDPDVSDS--LNYTFVQGN---ELRLLLLDPATGELQLSRDLDN 1168

Query: 1488 EELDHYILQVVASD 1501
                  +++V  SD
Sbjct: 1169 NRPLEALMEVSVSD 1182



 Score =  360 bits (924), Expect = 1e-98
 Identities = 303/993 (30%), Positives = 477/993 (48%), Gaps = 76/993 (7%)

Query: 460  FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS---DDPDR--FSLDKDTGL 514
            F  P Y ++L+EN   GT +L + A     G    VSY+     D+  R  F +D  TG 
Sbjct: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304

Query: 515  IMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRE 572
            +   + LD E  +   L + A D      +    I VL  D ND+ P F++  Y   +RE
Sbjct: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364

Query: 573  NEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
            N     +++ +RA+D DSP N  + Y ++     G++    L E  GV+S    LD E+ 
Sbjct: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLG----GAWDVFQLNESSGVVSTRAVLDREEA 420

Query: 633  SNGLIYLTVMAMDAG-NP-PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV 690
            +     L V A D G NP PL++T  V IEV DENDN P FS+  Y V V E++     V
Sbjct: 421  AE--YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478

Query: 691  LFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVD 750
            L + ATD D+ +       I S   + QF +++ SG +   + LD E   +Y L ++A D
Sbjct: 479  LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538

Query: 751  GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
            GG      +    V++ +LD+NDN P +  +P+   ++E  P    V  + AVD D GEN
Sbjct: 539  GGRPPLINSS-GVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597

Query: 811  GTLVYSI-------------------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
              L Y +                     P+  + +++++G I T  A LDRE  + +   
Sbjct: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI-TVCAELDREEVEHY--- 653

Query: 852  LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
                  V   D G PP+  +SS +V + +LD+NDNDP F    +   + E    G S+  
Sbjct: 654  ---SFGVEAVDHGSPPM--SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708

Query: 912  VVAIDLDEGLNGLVSYRMPVGMPRMDFLINS--SSGVVVTTTELDRERIAEYQLRVVASD 969
            + A D D   N +++Y++  G  R  F ++S    G++     LD ++  +Y L V ASD
Sbjct: 709  LQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766

Query: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
                T+S T+ + I+V D N   P F  + Y VSVSED P    +  L+  D D G NA 
Sbjct: 767  G---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823

Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
            ++Y I   +   +F +      + T++ LD E   AY L + A DNG   K  + T T+ 
Sbjct: 824  ITYVIQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK--SDTTTLE 879

Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN- 1148
            + +LD NDN P FL   Y+ S+ ED P   SILQ+ ATD D G  GR+ Y    G+ G+ 
Sbjct: 880  ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939

Query: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH-DLGPMRSSVRVIVYVEDINDEAPV 1207
            +F I  ++G++ R  R LDRE  + + L   A +     P+ +SV + V + DIND AP+
Sbjct: 940  DFYIEPTSGVI-RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998

Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLII 1266
            F + +   L + E   +G+ V  ++A D D G    + Y+I+ G     F++D   G + 
Sbjct: 999  FEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR 1057

Query: 1267 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE-------AVQFSNASYE 1319
             +  LD+E +  Y++ V AT  AP  ++   +V+I L+++ D         + F+N  Y 
Sbjct: 1058 AMVELDFEVRREYVLVVQAT-SAPLVSR--ATVHILLVDQNDNPPVLPDFQILFNN--YV 1112

Query: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
                 +   G  I  + A+  D  + + Y F          L  +D  TG + +   +D 
Sbjct: 1113 TNKSNSFPTGV-IGCIPAHDPDVSDSLNYTF---VQGNELRLLLLDPATGELQLSRDLDN 1168

Query: 1380 EKGDFYTLTVVADDGGPKVDSTVKVYITVLDEN 1412
             +     + V   DG   V +   + +T++ ++
Sbjct: 1169 NRPLEALMEVSVSDGIHSVTAFCTLRVTIITDD 1201



 Score =  358 bits (920), Expect = 4e-98
 Identities = 296/962 (30%), Positives = 449/962 (46%), Gaps = 87/962 (9%)

Query: 1756 EGQP-GPRVWTFLAHDRDSGPNGQVEY---SIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
            E +P G  +    AH    G   +V Y    + D    G F I    G   V  D  LDR
Sbjct: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA--VSTDSVLDR 313

Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871
            ET   + L + A D   PP S+T  + + V D ND+ PV         + EN  V   V 
Sbjct: 314  ETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVL 373

Query: 1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
             + ASD DS  NA L + +  G  +  F +N ++G+V+    LDRE   EY+L +   D 
Sbjct: 374  TIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQ 432

Query: 1932 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDAD 1991
              NP        +  I + DENDN+P F++  Y  +V E+   G    VL   + A D D
Sbjct: 433  GRNPGPLSATATVY-IEVEDENDNYPQFSEQNYVVQVPED--VGLNTAVLR--VQATDRD 487

Query: 1992 QDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVII-DREAFSPPILELLLLAEDIG-- 2047
            Q   A + Y +L G  +G F ++S +G++ V + +   D + +S     L + A+D G  
Sbjct: 488  QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS-----LSIKAQDGGRP 542

Query: 2048 -LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106
             L+NS+  + + +LD NDN P F  +     +LEN P G+ V+ + A D DSG N  L Y
Sbjct: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602

Query: 2107 RI-----------EAGAQDR-------FLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148
            R+            AG ++        F IH  +G I V  A +DREE E Y   V A D
Sbjct: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC-AELDREEVEHYSFGVEAVD 661

Query: 2149 RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLE 2208
             G+ P+S +  V+I + D+ND+ P F  P   + + E A  G+ +  + A D D N  + 
Sbjct: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVIT 721

Query: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268
            Y + G            N  + FA++   G  ++   +  +     +  L+V   ASD  
Sbjct: 722  YQLTG-----------GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV--TASD-- 766

Query: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328
                    A + +NV D N + P F+    ++Y   + E    GT++  ++A D D G N
Sbjct: 767  --GTRSHTAHVLINVTDANTHRPVFQS---SHYTVSVSEDRPVGTSIATLSANDEDTGEN 821

Query: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388
              +TY + D VP   +   D  +G +     +DYE       T+ A DNG P ++    +
Sbjct: 822  ARITYVIQDPVPQFRI---DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878

Query: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL---GDGE 2445
             + I+D NDN P F    YQ ++FED P  T IL V+ATD DSG    + Y+     DG+
Sbjct: 879  EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938

Query: 2446 SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
              F I PT+G I     LDRE    Y L ALA D       +    SV++ + +LD+ND 
Sbjct: 939  GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA---SVEIQVTILDINDN 995

Query: 2506 RPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGL 2564
             P F K +    V EN P G+ V  + A D DEGPN ++ Y + EG     F +D+ +G 
Sbjct: 996  APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD 1055

Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622
            +     L  +   ++ L V AT     PL     + + ++D NDN PV    P+  IL  
Sbjct: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVL---PDFQIL-F 1108

Query: 2623 REEIPLRSNVYEVYATD----KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
               +  +SN +           D  ++ ++ Y+F++  GN +    ++DP +G +Q ++ 
Sbjct: 1109 NNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ--GN-ELRLLLLDPATGELQLSRD 1165

Query: 2679 LD 2680
            LD
Sbjct: 1166 LD 1167



 Score =  334 bits (857), Expect = 8e-91
 Identities = 279/916 (30%), Positives = 442/916 (48%), Gaps = 90/916 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            + E+  VG  V  + A D D   N  L + V G  A   F +   +GVV  R  LDRE  
Sbjct: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA 420

Query: 99   SEFTVEFSVSDHQG------VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
            +E+ +    +D QG        T  V I+V D NDN P F  Q Y V++PE+  + T + 
Sbjct: 421  AEYQLLVEAND-QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479

Query: 153  IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
             V ATD D G   ++ YS        QF+ + S  GI+ VI  LD+E  Q Y L++ A D
Sbjct: 480  RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQD 538

Query: 210  QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
              +   +++   +++ + DV D +PIF++ P+   + E+ P G  V  I A+D D G   
Sbjct: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598

Query: 270  GIGYTIVSGNTNSI-----------------FALDYISGVLTLNGLLDRENPLYSHGFIL 312
             + Y +V   +  +                 F +   SG +T+   LDRE  +  + F  
Sbjct: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF-- 655

Query: 313  TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
               G E  D  +P  ++ +T+ +I V+D+NDN P F    Y + + E A VG ++ L +Q
Sbjct: 656  ---GVEAVDHGSPPMSS-STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV-LTLQ 710

Query: 373  VVDKDENLGLNSMFEVYLVGNNSHH-FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL 431
              D+D N    S+    L G N+ + F +S     G     I +A+PLDY+   +Y   +
Sbjct: 711  ARDRDAN----SVITYQLTGGNTRNRFALSSQRGGGL----ITLALPLDYKQEQQYVLAV 762

Query: 432  FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGT 491
             A++    H  +  + +T  + N +RP+F    Y +S+ E+  VGTS+ T+ A D D G 
Sbjct: 763  TASDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGE 820

Query: 492  FGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRI 549
               ++Y   D   +F +D D+G +  +  LDYE    +TLTI+A+D G   +  T  + I
Sbjct: 821  NARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
             +LD NDN P F  D Y G++ E+ P  T ++++ ATD DS PN ++ Y+          
Sbjct: 881  LILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG- 939

Query: 610  FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNP 668
             D  +    GVI   R LD E ++  +  L  +A+D G+P PL+++V + + + D NDN 
Sbjct: 940  -DFYIEPTSGVIRTQRRLDRENVA--VYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996

Query: 669  PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARS 725
            P F K    + V EN   G+ V  + A D D   E     I+Y + EG  +  F+++  +
Sbjct: 997  PMFEKDELELFVEENNPVGSVVAKIRANDPD---EGPNAQIMYQIVEGDMRHFFQLDLLN 1053

Query: 726  GEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYI 785
            G++     LD E + EY+L+V+A    +        ATV+I L+D NDN P   D     
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-----VSRATVHILLVDQNDNPPVLPDFQILF 1108

Query: 786  NLVEMTPPDSDVTTVV----AVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLD 841
            N       +S  T V+    A DPD+ ++    +      +   L+  TG+++ +    D
Sbjct: 1109 NNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR---D 1165

Query: 842  RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL------ 893
             +N  P EA LM    VSV+D G   + A  +  V +   D+  N  T   +N+      
Sbjct: 1166 LDNNRPLEA-LME---VSVSD-GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFL 1220

Query: 894  -PFVAEVLEGIPAGVS 908
             P +A  +EG+ A +S
Sbjct: 1221 SPLLALFVEGVAAVLS 1236



 Score =  330 bits (847), Expect = 1e-89
 Identities = 300/988 (30%), Positives = 454/988 (45%), Gaps = 76/988 (7%)

Query: 44   EDTPVGSSVTQLLAQ---DMDNDPLVFGVSG--EEASR-FFAVEPDTGVVWLRQPLDRET 97
            E+ P G+ + QL A    + + + + + + G  +E SR +F ++  TG V     LDRET
Sbjct: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315

Query: 98   KSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
            K    +     D+       T  + + V D ND++P F    Y  R+ EN  VG  +  +
Sbjct: 316  KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375

Query: 155  NATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
             A+D D     ++ Y     +   F ++ + G+V+    LD E    YQL V A DQ + 
Sbjct: 376  RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435

Query: 214  -RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
              PLS  A + I + D  D  P F    Y   + E     T V  + A D+D+G+   I 
Sbjct: 436  PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495

Query: 273  YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
            Y+I+SGN    F L  +SG+L +   LD E+      + L++K     D   P     + 
Sbjct: 496  YSILSGNVAGQFYLHSLSGILDVINPLDFED---VQKYSLSIKA---QDGGRPPLINSSG 549

Query: 333  TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLN----SMF 386
              ++ V+D+NDN P F SS +   + E   +G+ + + IQ VD D  EN  L+       
Sbjct: 550  VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-VHIQAVDADSGENARLHYRLVDTA 608

Query: 387  EVYLVGNNSHHFIISPT-----SVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDH 440
              +L G ++     +PT      +   +   I V   LD E V+ Y F + A +   P  
Sbjct: 609  STFLGGGSAGPKNPAPTPDFPFQIHNSSG-WITVCAELDREEVEHYSFGVEAVDHGSPPM 667

Query: 441  VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
                 V IT+++ NDN P+F+QP Y + L E+  VG+SVLT+ A D DA +         
Sbjct: 668  SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGG 727

Query: 501  DDPDRFSL--DKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
            +  +RF+L   +  GLI L   LDY+  Q++ L + A D G    T  V INV D N + 
Sbjct: 728  NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHR 786

Query: 559  PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
            P FQ   Y  ++ E+ P  T +  L A DED+  N +ITY I             +    
Sbjct: 787  PVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-----QFRIDPDS 841

Query: 619  GVISVSRPLDYEQISNGLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF 677
            G +     LDYE   N + Y LT+MA D G P  + T  + I + D NDN P F    Y 
Sbjct: 842  GTMYTMMELDYE---NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898

Query: 678  VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSL 733
             S+ E+     ++L ++ATD D S   G+  ++Y+ +G       F I   SG I T   
Sbjct: 899  GSIFEDAPPSTSILQVSATDRD-SGPNGR--LLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955

Query: 734  LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
            LDRE  + Y L   AVD G      +    + +T+LDINDN P ++     + + E  P 
Sbjct: 956  LDRENVAVYNLWALAVDRG-SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPV 1014

Query: 794  DSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
             S V  + A DPD G N  ++Y I   +   F+ L+   G +R   AM++       + E
Sbjct: 1015 GSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR---AMVEL------DFE 1065

Query: 852  LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT---FQNL--PFVAEVLEGIPAG 906
            + R+ V+ V     P     S ATV + L+D NDN P    FQ L   +V       P G
Sbjct: 1066 VRREYVLVVQATSAP---LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122

Query: 907  VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
            V I  + A D D  ++  ++Y    G      L++ ++G +  + +LD  R  E  + V 
Sbjct: 1123 V-IGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179

Query: 967  ASDAGTPTKSSTSTLTIHVLDVNDETPT 994
             SD      S T+  T+ V  + D+  T
Sbjct: 1180 VSDG---IHSVTAFCTLRVTIITDDMLT 1204



 Score =  314 bits (804), Expect = 1e-84
 Identities = 268/879 (30%), Positives = 418/879 (47%), Gaps = 74/879 (8%)

Query: 1634 FQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRIDRHMG 1690
            F  P+Y+V L E  +   T ++ + A    EG    V+Y    +        FRID   G
Sbjct: 245  FPMPNYQVALFEN-EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303

Query: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750
             ++    LD E     + L V A D     +   ++TT + V V D ND+ P F +  E 
Sbjct: 304  AVSTDSVLDRETKE-THVLRVKAVDYS---TPPRSATTYITVLVKDTNDHSPVFEQS-EY 358

Query: 1751 PFEVTEG-QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVEL 1809
               V E  + G  V T  A DRDS  N  + Y ++ G     F ++   GV+  R    L
Sbjct: 359  RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTR--AVL 415

Query: 1810 DRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVS 1867
            DRE  A Y L + A D+G  P  LS+T  V I V D NDN P        + + E+  ++
Sbjct: 416  DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475

Query: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
            + V  V A+D D G NA + ++I +GN    F++++ +GI+ V  PLD E + +Y L+I 
Sbjct: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535

Query: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
             +D    P I      ++ + + D NDN P+F  S +QA V+EN P G P+      I A
Sbjct: 536  AQDGGRPPLI--NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV----HIQA 589

Query: 1988 LDADQDIYAVVTYQLLGAQSGL------------------FDINSSTGVVTVRSGVIIDR 2029
            +DAD    A + Y+L+   S                    F I++S+G +TV +   +DR
Sbjct: 590  VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE--LDR 647

Query: 2030 EAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
            E        +  +      ++S+  + IT+LD NDN P F+  T  + L E+   G SVL
Sbjct: 648  EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707

Query: 2090 QVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVAT 2147
             + A D D+  N  + Y++  G  ++RF +    G   +  A  +D ++++ Y L V A+
Sbjct: 708  TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765

Query: 2148 DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NP 2205
            D GT   S TA V I + D N  RP F +   TVSV E    GT IA ++A D D   N 
Sbjct: 766  D-GT--RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENA 822

Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNAS 2265
            ++ Y             ++ +    F ++ ++G++     ++ E    Y +T+   DN  
Sbjct: 823  RITY-------------VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG- 868

Query: 2266 DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDK 2325
             +P++S       L + +LD NDN PQF      +Y   I E A P T+++ V+A D D 
Sbjct: 869  -IPQKS---DTTTLEILILDANDNAPQFL---WDFYQGSIFEDAPPSTSILQVSATDRDS 921

Query: 2326 GLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAA 2384
            G NG + YT             + ++G +   R +D E V   N    A D GSP P +A
Sbjct: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981

Query: 2385 EIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG 2444
             + + + I+DINDN P+F++   +  V E+ PVG+++  + A D D G  A I Y + +G
Sbjct: 982  SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041

Query: 2445 ESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481
            + +  F ++   GD+  +  LD E +  Y+L   A   P
Sbjct: 1042 DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP 1080



 Score =  313 bits (802), Expect = 2e-84
 Identities = 255/844 (30%), Positives = 396/844 (46%), Gaps = 89/844 (10%)

Query: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVTGVIRVGNAT 2131
            V L EN P G  +LQ+ A     G    + Y +E    +R    F I   TG +   ++ 
Sbjct: 252  VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST-DSV 310

Query: 2132 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2191
            +DRE +E++ L V A D  T P S T  +T+L+ D ND  P F        V E+ E G 
Sbjct: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370

Query: 2192 VIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249
             +  I A D D  +N  L Y ++G               D F +N ++G V  ++ ++RE
Sbjct: 371  EVLTIRASDRDSPINANLRYRVLG------------GAWDVFQLNESSGVVSTRAVLDRE 418

Query: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309
              A Y++ +   D   +    S +   A + + V D NDN PQF       Y+ ++ E  
Sbjct: 419  EAAEYQLLVEANDQGRNPGPLSAT---ATVYIEVEDENDNYPQFSEQN---YVVQVPEDV 472

Query: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN 2369
               T ++ V A D D+G N  + Y++L     G   L   S    + N  +D+E+V   +
Sbjct: 473  GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYS 531

Query: 2370 FTVRASDNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
             +++A D G PP      V  ++++D+NDN PIF    +Q  V E+VP+G  ++ + A D
Sbjct: 532  LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591

Query: 2429 ADSGNFALIEYSLGDGESKFA-------------------INPTTGDIYVLSSLDREKKD 2469
            ADSG  A + Y L D  S F                    I+ ++G I V + LDRE+ +
Sbjct: 592  ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
            HY     A D+     S    +S  V I VLDVND  P F++P +   + E+   G+SV+
Sbjct: 652  HYSFGVEAVDH----GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707

Query: 2530 TMMATDQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPL--QSYEKFSLTVVAT 2584
            T+ A D+D   N  +TY L G       A       GL+T   PL  +  +++ L V A+
Sbjct: 708  TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765

Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644
            DG       T  +L+ V D N +RPVF    +   + + E+ P+ +++  + A D+D G 
Sbjct: 766  DGTRSH---TAHVLINVTDANTHRPVF--QSSHYTVSVSEDRPVGTSIATLSANDEDTGE 820

Query: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYET 2704
            N  + Y             F IDP SG + T   LD E+Q  Y+L ++A D G P   +T
Sbjct: 821  NARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDT 875

Query: 2705 MQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIV 2764
               L++ + D +DN P F+        +   ++ E +P  T +  V+ A D D GPN  +
Sbjct: 876  TT-LEILILDANDNAPQFLW------DFYQGSIFEDAPPSTSILQVS-ATDRDSGPNGRL 927

Query: 2765 YYFIAAGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
             Y    G++ + +F+++P  G +   R LDRE  A+++    A    S TP         
Sbjct: 928  LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP--------- 978

Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
            L A +   E++V + DIND  P F K E    V  +  VGS + ++ A D D G N+ + 
Sbjct: 979  LSASV---EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIM 1035

Query: 2883 YSIL 2886
            Y I+
Sbjct: 1036 YQIV 1039



 Score =  183 bits (465), Expect = 2e-45
 Identities = 150/521 (28%), Positives = 238/521 (45%), Gaps = 33/521 (6%)

Query: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTG-- 85
            P FT   ++  L ++ED  VGSSV  L A+D D N  + + ++G      FA+    G  
Sbjct: 685  PVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742

Query: 86   VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
            ++ L  PLD + + ++ +  + SD     T  V I V D N + P F +  Y+V + E+ 
Sbjct: 743  LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802

Query: 146  PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTV 205
            PVGT I  ++A D D G    + Y  Q P   F ID   G +  + ELDYE   AY LT+
Sbjct: 803  PVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTI 862

Query: 206  NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
             A D    +   T   L I+I D  D  P F+   Y  +I+E +PP T++  ++A D+D 
Sbjct: 863  MAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921

Query: 266  GRPRGIGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
            G    + YT   G+  +  F ++  SGV+     LDREN    + + L V      D  +
Sbjct: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAV------DRGS 975

Query: 325  PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
            P+  + +    + ++DINDNAP F   E  + + E   VG ++   I+  D DE      
Sbjct: 976  PTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG-SVVAKIRANDPDEGPNAQI 1034

Query: 385  MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYA 444
            M+++ + G+  H F +   +        +R  + LD+E   R ++ L    +    V  A
Sbjct: 1035 MYQI-VEGDMRHFFQLDLLNGD------LRAMVELDFEV--RREYVLVVQATSAPLVSRA 1085

Query: 445  KVKITLINENDNRPIFSQPLYNISLYENVTVGTS-------VLTVLATDNDAGTFGEVSY 497
             V I L+++NDN P+   P + I L+ N     S       +  + A D D       ++
Sbjct: 1086 TVHILLVDQNDNPPVL--PDFQI-LFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTF 1142

Query: 498  FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDG 538
               ++     LD  TG + L   LD        + +   DG
Sbjct: 1143 VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDG 1183



 Score =  161 bits (407), Expect = 1e-38
 Identities = 120/387 (31%), Positives = 189/387 (48%), Gaps = 33/387 (8%)

Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA----FHVDMDSG 2563
            +F  P +  +++ENEPAGT ++ + A    EG    ++Y +EG   E     F +D  +G
Sbjct: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303

Query: 2564 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
             V+T   L  ++ E   L V A D   PP   TT + V V D ND+ PVF +        
Sbjct: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE--R 361

Query: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDR 2681
            +RE + +   V  + A+D+D  +N  +RY  L  A    W+ F ++  SG++ T   LDR
Sbjct: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDR 417

Query: 2682 ESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 2740
            E  A Y L++ A+D G+ P P      + + +ED +DN P F      S Q  ++ VPE 
Sbjct: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF------SEQNYVVQVPED 471

Query: 2741 SPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF 2799
                T V  V  A D D+G NA ++Y I +GN    F+L    G L V+  LD E    +
Sbjct: 472  VGLNTAVLRVQ-ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530

Query: 2800 SFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDA 2859
            S  +KA          G  P ++    +++Q +     D+ND  P F  + + A V  + 
Sbjct: 531  SLSIKAQDG-------GRPPLINSSGVVSVQVL-----DVNDNEPIFVSSPFQATVLENV 578

Query: 2860 KVGSELIQVLALDADIGNNSLVFYSIL 2886
             +G  ++ + A+DAD G N+ + Y ++
Sbjct: 579  PLGYPVVHIQAVDADSGENARLHYRLV 605



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 80/291 (27%), Positives = 127/291 (43%), Gaps = 30/291 (10%)

Query: 2624 EEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES 2683
            E  P  + + +++A    EG    V Y        R   +F ID  +G + T   LDRE+
Sbjct: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315

Query: 2684 QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743
            +  + L + A D   P P      + V ++D +D+ P+F +      +Y+   V E+   
Sbjct: 316  KETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQS-----EYRE-RVRENLEV 368

Query: 2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIV 2803
            G  V  +  A D D   NA + Y +  G  +     +  G +     LDRE  A +  +V
Sbjct: 369  GYEVLTIR-ASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427

Query: 2804 KASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGS 2863
            +A+        R P P   L A  T   V + +ED ND  P+F++  Y   V  D  + +
Sbjct: 428  EANDQG-----RNPGP---LSATAT---VYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476

Query: 2864 ELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
             +++V A D D G N+ + YSIL           S +V   F + S+ GIL
Sbjct: 477  AVLRVQATDRDQGQNAAIHYSIL-----------SGNVAGQFYLHSLSGIL 516


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score =  395 bits (1015), Expect = e-109
 Identities = 315/982 (32%), Positives = 483/982 (49%), Gaps = 58/982 (5%)

Query: 455  DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLD 509
            +  P F Q  Y   + EN   GT+VL V+A D DAG  G + Y       S   + FS+D
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379

Query: 510  KDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYV 567
              +GLI   A LD E ++R  L + A+D G      T  V + V D ND+ P F++  Y 
Sbjct: 380  PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439

Query: 568  GALRENEPSVTQLVRLRATDEDSPPNNQITYSIV----SASAFGSYFDISLYEGYGVISV 623
              LREN      +++LRATD D+PPN  + Y  V    + +A  + F+I      G+IS 
Sbjct: 440  ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID--PRSGLIST 497

Query: 624  SRPLDYEQISNGLIYLTVMAMDAGNP--PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
            S  +D E + +    L V A D G    P ++TV V I V DENDN P FS+  Y   V 
Sbjct: 498  SGRVDREHMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555

Query: 682  ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE 741
            E++     VL + ATD D+         I S      F I++ +GEI   + LD E + E
Sbjct: 556  EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615

Query: 742  YILIVRAVDGG-VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800
            Y L +RA D G    +  TG+A++ +  +DIND+ P +   P+ ++++E  P    V  +
Sbjct: 616  YALRIRAQDAGRPPLSNNTGLASIQV--VDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673

Query: 801  VAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
             AVD D GEN  L YS+    P+  + +NS TG + +    LDRE+ + +         V
Sbjct: 674  QAVDADHGENARLEYSLTGVAPDTPFVINSATGWV-SVSGPLDRESVEHY------FFGV 726

Query: 859  SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
               D G PPL A++S TV V  LD+NDN P F    +   + E    G S+  V A+D D
Sbjct: 727  EARDHGSPPLSASASVTVTV--LDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD 784

Query: 919  EGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLRVVASDAGTPTKS 976
               N  +SY++  G  R  F I++  GV  V     LD ++   ++L + ASD       
Sbjct: 785  --ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL---H 839

Query: 977  STSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
                + I++ D N   P F  A Y+VSV+ED P    +V ++ +D+DVG NA ++Y +  
Sbjct: 840  DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899

Query: 1037 GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVN 1096
                 +F +      +     LD E    Y L + A DNG   K    T  V V V DVN
Sbjct: 900  NL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK--ADTTYVEVMVNDVN 955

Query: 1097 DNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN-NFRIHVS 1155
            DN P F+ S Y   V ED P   S+LQ+ ATD D    GRV Y   +G  G+ +F I  +
Sbjct: 956  DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1015

Query: 1156 NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSR 1215
            +G ++R  R LDRE  S + L   A +  + P+R+ V + V V+D+ND APVF  +++  
Sbjct: 1016 SG-IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF-E 1073

Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYE 1274
            + ++E + +G+ V  + A D D G    + Y+I+ G     F++D  +G +  +  LDYE
Sbjct: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133

Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN-----ASYEAAILENLALG 1329
             +  Y++ V AT  AP  ++   +V++ L+++ D +   +N      +Y +   +    G
Sbjct: 1134 ARQEYVIVVQAT-SAPLVSR--ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG 1190

Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
              I R+ AY  D  + + Y F      Q   L  ++  +G + +   +D  +    ++ V
Sbjct: 1191 I-IGRIPAYDPDVSDHLFYSFERGNELQ---LLVVNQTSGELRLSRKLDNNRPLVASMLV 1246

Query: 1390 VADDGGPKVDSTVKVYITVLDE 1411
               DG   V +   + + ++ E
Sbjct: 1247 TVTDGLHSVTAQCVLRVVIITE 1268



 Score =  385 bits (990), Expect = e-106
 Identities = 290/944 (30%), Positives = 458/944 (48%), Gaps = 47/944 (4%)

Query: 559  PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
            P F +  Y   + ENE + T ++R+ A D D+    ++ YS+ +     S    S+    
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382

Query: 619  GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
            G+I  +  LD E +     YL V A D G+P L++T  V + V D ND+ P F +  Y  
Sbjct: 383  GLIRTAAALDRESMERH--YLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRE 440

Query: 679  SVVENIMAGATVLFLNATDLD-------RSREYGQESIIYSLEGSTQFRINARSGEITTT 731
            ++ EN+  G  +L L ATD D       R R  G  +       +  F I+ RSG I+T+
Sbjct: 441  TLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAA--RAAAAAAFEIDPRSGLISTS 498

Query: 732  SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
              +DRE    Y L+V A D G     ++    V+IT+LD NDN P + +  Y   + E  
Sbjct: 499  GRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDV 558

Query: 792  PPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHE 849
             P + V  V A D D   NG + Y+I   N    ++++S TG+I+   A LD       E
Sbjct: 559  RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLD------FE 611

Query: 850  AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
            AE    + +   D GRPPL + ++    + ++D+ND+ P F + PF   VLE  P G S+
Sbjct: 612  AEREYALRIRAQDAGRPPL-SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670

Query: 910  YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
              + A+D D G N  + Y +    P   F+INS++G V  +  LDRE +  Y   V A D
Sbjct: 671  IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730

Query: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
             G+P  S+++++T+ VLDVND  P F    Y++ ++ED      VV +   D D   N+ 
Sbjct: 731  HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSA 788

Query: 1030 LSYFITGGNVDGKFSVGYRDAV--VRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
            +SY ITGGN   +F++  +  V  V   + LD +    + L+L A D     +       
Sbjct: 789  ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-----RALHDHCY 843

Query: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG 1147
            V + + D N +RP+F  + Y  SV ED P G +I+ + A+D D GE  R+ Y  L  ++ 
Sbjct: 844  VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY--LLEDNL 901

Query: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207
              FRI   +G +     PLD E   ++ L + A ++ +     +  V V V D+ND AP 
Sbjct: 902  PQFRIDADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960

Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEGKFEIDESTGLI 1265
            F    Y+ L + E A   TSV+ + ATDRD+   G V Y   +G   +G F I+ ++G++
Sbjct: 961  FVASHYTGL-VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019

Query: 1266 ITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
             TV  LD E  + Y +   A D+  P  +   S+ + + +  D A  F    +E  + EN
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079

Query: 1326 LALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFY 1385
              +G+ + ++ A   D      +            LF++D  +G +T    +D E    Y
Sbjct: 1080 SIVGSVVAQITAVDPDE-GPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY 1138

Query: 1386 TLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSIPEDCPVGQRVATVK 1442
             + V A    P V S   V++ ++D+NDNSP    F    ++ VS   D      +  + 
Sbjct: 1139 VIVVQA-TSAPLV-SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196

Query: 1443 AWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLD 1486
            A+DPD   +  + +S   GN     +++  N + GE+ ++R LD
Sbjct: 1197 AYDPDVSDH--LFYSFERGN---ELQLLVVNQTSGELRLSRKLD 1235



 Score =  380 bits (977), Expect = e-105
 Identities = 295/959 (30%), Positives = 462/959 (48%), Gaps = 70/959 (7%)

Query: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDRISGEIAT 1587
            + Y   V EN   GTAV++V A D D G    L Y +       +   F +D  SG I T
Sbjct: 328  YNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRT 387

Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
              A  DRE    ++L  T +D G+P LSATT V VT+ D ND++P+F+Q  Y   L E  
Sbjct: 388  AAAL-DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENV 446

Query: 1648 DTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT-----FRIDRHMGVITAAKELDYEI 1702
            +     ++ ++A D D  PN  + Y  V            F ID   G+I+ +  +D E 
Sbjct: 447  EE-GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH 505

Query: 1703 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
                Y L+V A+DQ      R ++T  V + V D NDN P F           + +P   
Sbjct: 506  MES-YELVVEASDQGQEPGPR-SATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV 563

Query: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRK--DVELDRETIAFYNLT 1820
            V    A DRD   NG V Y+I+ G+  G F I  + G ++V    D E +RE    Y L 
Sbjct: 564  VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE----YALR 619

Query: 1821 ICARDRGMPPLSS-TMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
            I A+D G PPLS+ T L  I+V+DIND+ P+ ++ P  +++ EN+P+   V H+ A DAD
Sbjct: 620  IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679

Query: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1939
             G NARL +++T    +  F IN+ TG V+V+ PLDRE +  Y   +  +D+   P  A 
Sbjct: 680  HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSAS 739

Query: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
                + ++   D NDN P FT   Y   + E++  GT +  +         D+D  + ++
Sbjct: 740  ASVTVTVL---DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA------VDRDANSAIS 790

Query: 2000 YQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
            YQ+ G  +   F I++  GV  V   + +D +       +L+L A D   L+   ++ I 
Sbjct: 791  YQITGGNTRNRFAISTQGGVGLVTLALPLDYK--QERYFKLVLTASD-RALHDHCYVHIN 847

Query: 2059 ILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLI 2118
            I D N +RP F  A  +V + E+ P G +++ ++A+D+D G N  + Y +E     +F I
Sbjct: 848  ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-PQFRI 906

Query: 2119 HLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
               +G I +  A +D E+Q +Y L + A D G    + T  V ++++D+ND+ P+F+   
Sbjct: 907  DADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965

Query: 2179 QTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAV 2233
             T  V E A P T +  I+A D D   N +++Y                N ED    F +
Sbjct: 966  YTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-------------TFQNGEDGDGDFTI 1012

Query: 2234 NINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
               +G V     ++RE V+ YE+T   +D         VS+      V V DVNDN P F
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSI-----QVMVQDVNDNAPVF 1067

Query: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
                   +  R+ E +  G+ +  + AVDPD+G N  + Y +++   P   Q+ D  +G+
Sbjct: 1068 P---AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQM-DIFSGE 1123

Query: 2354 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ-----PSYQ 2408
            + A   +DYE        V+A+   S P  +   V++ +VD NDN+P+ +       +Y 
Sbjct: 1124 LTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYV 1180

Query: 2409 EAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREK 2467
                +  P G II  + A D D  +     +  G+      +N T+G++ +   LD  +
Sbjct: 1181 SNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNR 1238



 Score =  380 bits (976), Expect = e-104
 Identities = 282/874 (32%), Positives = 433/874 (49%), Gaps = 67/874 (7%)

Query: 1954 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG----L 2009
            + HP F +  YQ  V EN  AGT +      ++A D D      + Y L    +     L
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAGTAVL----RVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375

Query: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
            F I+  +G+  +R+   +DRE+     L +         L++T  + +T+ D ND+ P F
Sbjct: 376  FSIDPQSGL--IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVF 433

Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTG 2123
              A     L EN   G+ +LQ+ ATD D+  N  L YR        A A   F I   +G
Sbjct: 434  EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTV--PLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
            +I   +  +DRE  ESY L V A+D+G    P S T  V I + D ND+ P+F       
Sbjct: 494  LIST-SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552

Query: 2182 SVLESAEPGTVIANITAIDH--DLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
             V E   P TV+  +TA D   D N  + Y+I+             N    FA++  TG 
Sbjct: 553  QVREDVRPHTVVLRVTATDRDKDANGLVHYNIIS-----------GNSRGHFAIDSLTGE 601

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            + V +P++ E    Y + +     A D     +S      ++ V+D+ND+ P F     T
Sbjct: 602  IQVVAPLDFEAEREYALRI----RAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS---T 654

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
             +   +LE A  G ++I + AVD D G N  + Y+L  + P     + +S+ G V  +  
Sbjct: 655  PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVI-NSATGWVSVSGP 713

Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
            +D E V    F V A D+GSPP +A   V + ++D+NDN P F    Y   + ED  VGT
Sbjct: 714  LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773

Query: 2420 IILTVTATDADSGNFALIEYSLGDGESKFAINPT--TGDIYVLSSLDREKKDHYILTALA 2477
             +++VTA D D+ +    + + G+  ++FAI+     G + +   LD +++ ++ L   A
Sbjct: 774  SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA 833

Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
             D           +   V I + D N  RP F    +S SV E+ P G++++ + A+D D
Sbjct: 834  SD-------RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886

Query: 2538 EGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTT 2595
             G N  +TY LE   +  F +D DSG +T Q PL   ++  ++L + A D G P    TT
Sbjct: 887  VGENARITYLLE-DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTT 945

Query: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK- 2654
             + V V DVNDN P FV      +  + E+ P  ++V ++ ATD+D   NG V+Y+F   
Sbjct: 946  YVEVMVNDVNDNAPQFVASHYTGL--VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNG 1003

Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
              G+ D   F I+P SG+++T +RLDRE+ +VY L   A D G P P  T   +QV ++D
Sbjct: 1004 EDGDGD---FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQD 1059

Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
            ++DN P+F      + +++ + V E+S  G++V  +T AVD DEGPNA + Y I  GN  
Sbjct: 1060 VNDNAPVF-----PAEEFE-VRVKENSIVGSVVAQIT-AVDPDEGPNAHIMYQIVEGNIP 1112

Query: 2775 KNFHLQP-DGCLLVLRDLDREREAIFSFIVKASS 2807
            + F +    G L  L DLD E    +  +V+A+S
Sbjct: 1113 ELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146



 Score =  370 bits (949), Expect = e-101
 Identities = 293/918 (31%), Positives = 451/918 (49%), Gaps = 71/918 (7%)

Query: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487
            +PE+   G  V  V A DPDAG  G++V+SLA+   + + E+ + +   G +  A  LDR
Sbjct: 334  VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393

Query: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
            E ++ + L+V A D G+P      ++ VT+ D ND+ PV E    Y  ++ ENV  G  +
Sbjct: 394  ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQA-QYRETLRENVEEGYPI 452

Query: 1548 VQVRATDRDIGINSVLSYYI-----TEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
            +Q+RATD D   N+ L Y              AF +D  SG I+T     DRE    Y L
Sbjct: 453  LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST-SGRVDREHMESYEL 511

Query: 1603 VATVEDEGTP--TLSATTHVYVTIVDENDNAPMFQQPHY--EVLLDEGPDTLNTSLITIQ 1658
            V    D+G      SAT  V++T++DENDNAP F +  Y  +V  D  P T+   ++ + 
Sbjct: 512  VVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV---VLRVT 568

Query: 1659 ALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ-C 1717
            A D D+  NG V Y I++GN    F ID   G I     LD+E +   Y L + A D   
Sbjct: 569  ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE-AEREYALRIRAQDAGR 627

Query: 1718 PILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSG 1774
            P LS+   +T    + V DIND++P F      PF+V+  E  P G  V    A D D G
Sbjct: 628  PPLSN---NTGLASIQVVDINDHIPIF---VSTPFQVSVLENAPLGHSVIHIQAVDADHG 681

Query: 1775 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1834
             N ++EYS+    P   FVI+   G + V     LDRE++  Y   + ARD G PPLS++
Sbjct: 682  ENARLEYSLTGVAPDTPFVINSATGWVSV--SGPLDRESVEHYFFGVEARDHGSPPLSAS 739

Query: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGN 1894
              V + VLD+NDN P       ++ ++E++ V + V  V A D D+  N+ +++ IT GN
Sbjct: 740  ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGN 797

Query: 1895 RERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDE 1952
                F I+     G+VT+  PLD ++   +KL ++  D       A  D+  + I ++D 
Sbjct: 798  TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR------ALHDHCYVHINITDA 851

Query: 1953 NDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDI 2012
            N + P+F  + Y   V E+ P G+ + V++    A D D    A +TY LL      F I
Sbjct: 852  NTHRPVFQSAHYSVSVNEDRPMGSTIVVIS----ASDDDVGENARITY-LLEDNLPQFRI 906

Query: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFS 2070
            ++ +G +T+++ +  + +        L + A D G+     T ++ + + D NDN P F 
Sbjct: 907  DADSGAITLQAPLDYEDQV----TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG--AQDRFLIHLVTGVIRVG 2128
             +  T  + E+ PP  SVLQ++ATD D+  NG + Y  + G      F I   +G++R  
Sbjct: 963  ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022

Query: 2129 NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
               +DRE    Y LT  A DRG  PL     + +++ D+ND+ P F      V V E++ 
Sbjct: 1023 R-RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081

Query: 2189 PGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR 2248
             G+V+A ITA+D D  P    HI+  + +        N  + F ++I +G +     ++ 
Sbjct: 1082 VGSVVAQITAVDPDEGPNA--HIMYQIVEG-------NIPELFQMDIFSGELTALIDLDY 1132

Query: 2249 ELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY--YMERIL 2306
            E    Y + +     A+  P     V  A + V ++D NDN+P    F I +  Y+    
Sbjct: 1133 EARQEYVIVV----QATSAP----LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSN-R 1183

Query: 2307 EGATPGTTLIAVAAVDPD 2324
                P   +  + A DPD
Sbjct: 1184 SDTFPSGIIGRIPAYDPD 1201



 Score =  362 bits (930), Expect = 3e-99
 Identities = 279/883 (31%), Positives = 423/883 (47%), Gaps = 48/883 (5%)

Query: 346  PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSV 405
            P+F    Y   + E    G A+   ++VV +D + G      VY +    +   +   S+
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAV---LRVVAQDPDAGEAGRL-VYSLAALMNSRSLELFSI 378

Query: 406  QGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPL 464
              ++ + IR A  LD E+++R+   + A +   P       V +T+ + ND+ P+F Q  
Sbjct: 379  DPQSGL-IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437

Query: 465  YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP-------DRFSLDKDTGLIML 517
            Y  +L ENV  G  +L + ATD DA     + Y F   P         F +D  +GLI  
Sbjct: 438  YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497

Query: 518  IARLDYELIQRFTLTIIARDGGGE----ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
              R+D E ++ + L + A D G E      T RV I VLD NDN P F +  YV  +RE+
Sbjct: 498  SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557

Query: 574  EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
                T ++R+ ATD D   N  + Y+I+S ++ G +   SL    G I V  PLD+E  +
Sbjct: 558  VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSL---TGEIQVVAPLDFE--A 612

Query: 634  NGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
                 L + A DAG PPL N+T   +I+V D ND+ P F    + VSV+EN   G +V+ 
Sbjct: 613  EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672

Query: 693  LNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
            + A D D       E  +  +   T F IN+ +G ++ +  LDRE+   Y   V A D  
Sbjct: 673  IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH- 731

Query: 753  VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGT 812
             G    +  A+V +T+LD+NDN P +    Y++ L E     + V +V AVD D   N  
Sbjct: 732  -GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSA 788

Query: 813  LVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
            + Y I   N    +++++  G    T A+     P  ++ E   K+V++ +D        
Sbjct: 789  ISYQITGGNTRNRFAISTQGGVGLVTLAL-----PLDYKQERYFKLVLTASD-----RAL 838

Query: 871  TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
                 V +N+ D N + P FQ+  +   V E  P G +I  + A D D G N  ++Y + 
Sbjct: 839  HDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898

Query: 931  VGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
              +P+  F I++ SG +     LD E    Y L + A D G P K+ T+ + + V DVND
Sbjct: 899  DNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956

Query: 991  ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY-FITGGNVDGKFSVGYRD 1049
              P F  + Y   VSED P    V+ ++ TD D   N  + Y F  G + DG F++    
Sbjct: 957  NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS 1016

Query: 1050 AVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
             +VRTV  LDRE  + Y L   A+D G    R     ++ V V DVNDN P+F    +E 
Sbjct: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLR--TPVSIQVMVQDVNDNAPVFPAEEFEV 1074

Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
             V E+   G  + Q+ A D DEG    + Y+I+ GN    F++ + +G L      LD E
Sbjct: 1075 RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYE 1133

Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
                +V++V+A +    P+ S   V V + D ND +PV    Q
Sbjct: 1134 ARQEYVIVVQATS---APLVSRATVHVRLVDQNDNSPVLNNFQ 1173



 Score =  362 bits (928), Expect = 4e-99
 Identities = 319/1059 (30%), Positives = 504/1059 (47%), Gaps = 89/1059 (8%)

Query: 1860 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDR 1916
            + EN    + V  V+A D D+G   RL +++ A    R+   F I+  +G++     LDR
Sbjct: 334  VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393

Query: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
            E +  + L ++ +D+  +PR++     ++ + ++D ND+ P+F ++ Y+  + EN   G 
Sbjct: 394  ESMERHYLRVTAQDHG-SPRLSATT--MVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450

Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLLG------AQSGLFDINSSTGVVTVRSGVIIDRE 2030
            P+  L     A D D    A + Y+ +G      A +  F+I+  +G+++    V  DRE
Sbjct: 451  PILQLR----ATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV--DRE 504

Query: 2031 AFSPPILELLLLAEDIGL----LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086
                   EL++ A D G      ++T  + IT+LD+NDN P FS       + E+  P  
Sbjct: 505  HMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562

Query: 2087 SVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
             VL+VTATD D   NG + Y I +G ++  F I  +TG I+V  A +D E +  Y L + 
Sbjct: 563  VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLDFEAEREYALRIR 621

Query: 2146 ATDRGTVPLSG-TAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAID--HD 2202
            A D G  PLS  T + +I + DIND  P F++    VSVLE+A  G  + +I A+D  H 
Sbjct: 622  AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681

Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
             N +LEY + G+             +  F +N  TG V V  P++RE V  Y   +   D
Sbjct: 682  ENARLEYSLTGVAP-----------DTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730

Query: 2263 NASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVD 2322
            + S  P  S S   A +TV VLDVNDN P+F    +  Y  R+ E A  GT++++V AVD
Sbjct: 731  HGS--PPLSAS---ASVTVTVLDVNDNRPEFT---MKEYHLRLNEDAAVGTSVVSVTAVD 782

Query: 2323 PDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP 2381
             D   N  ++Y +          +      G V     +DY++  +    + ASD     
Sbjct: 783  RDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD 840

Query: 2382 RAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
                  V++ I D N + P+F    Y  +V ED P+G+ I+ ++A+D D G  A I Y L
Sbjct: 841  HCY---VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL 897

Query: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501
             D   +F I+  +G I + + LD E +  Y L   A+DN       ++ ++  V + V D
Sbjct: 898  EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDN----GIPQKADTTYVEVMVND 953

Query: 2502 VNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG--PGVEAFHVD 2559
            VND  PQF    ++  V E+ P  TSV+ + ATD+D   NG + Y+ +    G   F ++
Sbjct: 954  VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013

Query: 2560 MDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
              SG+V T R L  ++   + LT  A D G PPL     + V V DVNDN PVF  P   
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF--PAEE 1071

Query: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ 2677
              + ++E   + S V ++ A D DEG N  + Y  ++  GN   E F +D  SG +    
Sbjct: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVE--GNIP-ELFQMDIFSGELTALI 1128

Query: 2678 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
             LD E++  Y +++ A+      P  +   + V L D +DN P+          +Q+L  
Sbjct: 1129 DLDYEARQEYVIVVQATS----APLVSRATVHVRLVDQNDNSPVL-------NNFQILFN 1177

Query: 2738 PEHSPRG-TLVGNVTGAVDA-DEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDRE 2794
               S R  T    + G + A D   +  ++Y    GNE +   + Q  G L + R LD  
Sbjct: 1178 NYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNN 1237

Query: 2795 REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK---AEY 2851
            R  + S +V  +        +     + +  +L    + V LE++  +  RF       +
Sbjct: 1238 RPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQE--RFLSPLLGRF 1295

Query: 2852 TAGVATDAKVGSELIQVLAL--DADIGNNSL-VFYSILA 2887
              GVA      +E + +  +  D D+G   L V +S LA
Sbjct: 1296 LEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALA 1334



 Score =  348 bits (893), Expect = 5e-95
 Identities = 281/905 (31%), Positives = 449/905 (49%), Gaps = 86/905 (9%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRF-----FAVEPDTGVVWLRQPL 93
            + E+   G  + QL A D D  P   L +   G  A+R      F ++P +G++     +
Sbjct: 442  LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501

Query: 94   DRETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
            DRE    + +    SD QG        T +V+I V D NDNAP F  + Y  ++ E+   
Sbjct: 502  DREHMESYELVVEASD-QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560

Query: 148  GTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTV 205
             T +  V ATD D  A G V Y+    +    FAIDS  G + V+  LD+E  + Y L +
Sbjct: 561  HTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRI 620

Query: 206  NATDQDKTRPLSTLANLAII-ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
             A D  +  PLS    LA I + D+ D  PIF++ P+  ++ E++P G +V  I A+D D
Sbjct: 621  RAQDAGRP-PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679

Query: 265  KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
             G    + Y++     ++ F ++  +G ++++G LDRE+    H F     G E  D  +
Sbjct: 680  HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRES--VEHYFF----GVEARDHGS 733

Query: 325  P---SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
            P   + A+VT T    V+D+NDN PEF   EY + + E A VG ++ + +  VD+D N  
Sbjct: 734  PPLSASASVTVT----VLDVNDNRPEFTMKEYHLRLNEDAAVGTSV-VSVTAVDRDANSA 788

Query: 382  LNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDH 440
            ++        GN  + F I   S QG   + + +A+PLDY+    +   L A++ ++ DH
Sbjct: 789  ISYQI---TGGNTRNRFAI---STQGGVGL-VTLALPLDYKQERYFKLVLTASDRALHDH 841

Query: 441  VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
                 V I + + N +RP+F    Y++S+ E+  +G++++ + A+D+D G    ++Y   
Sbjct: 842  ---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898

Query: 501  DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNV 558
            D+  +F +D D+G I L A LDYE    +TL I ARD G   +  T  V + V DVNDN 
Sbjct: 899  DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 958

Query: 559  PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
            P F    Y G + E+ P  T ++++ ATD D+  N ++ Y+  +        D ++    
Sbjct: 959  PQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG--DFTIEPTS 1016

Query: 619  GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
            G++   R LD E +S  +  LT  A+D G PPL + V + + V D NDN P F    + V
Sbjct: 1017 GIVRTVRRLDREAVS--VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEV 1074

Query: 679  SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLD 735
             V EN + G+ V  + A D D   E     I+Y + EG+    F+++  SGE+T    LD
Sbjct: 1075 RVKENSIVGSVVAQITAVDPD---EGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131

Query: 736  RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPY----YINLVEMT 791
             E + EY+++V+A    +        ATV++ L+D NDN P   +       Y++    T
Sbjct: 1132 YEARQEYVIVVQATSAPL-----VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDT 1186

Query: 792  PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL--NSTTGKIRTTHAMLDRENPDPHE 849
             P   +  + A DPD+ ++  L YS +  N+   L  N T+G++R +   LD   P    
Sbjct: 1187 FPSGIIGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSR-KLDNNRP---- 1239

Query: 850  AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL-------PFVAEVL 900
              L+  ++V+VTD G   + A     V +   +L  N  T   +N+       P +   L
Sbjct: 1240 --LVASMLVTVTD-GLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFL 1296

Query: 901  EGIPA 905
            EG+ A
Sbjct: 1297 EGVAA 1301



 Score =  335 bits (859), Expect = 4e-91
 Identities = 292/996 (29%), Positives = 463/996 (46%), Gaps = 76/996 (7%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASR---FFA 79
            NR P F  + + T  L+ E+   G++V +++AQD D      LV+ ++    SR    F+
Sbjct: 320  NRHPQFPQYNYQT--LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377

Query: 80   VEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQP 136
            ++P +G++     LDRE+     +  +  DH       T  V + V D ND++P F    
Sbjct: 378  IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437

Query: 137  YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP-------SQFFAIDSARGIVTV 189
            Y   + EN   G PI  + ATD D     ++ Y F  P       +  F ID   G+++ 
Sbjct: 438  YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497

Query: 190  IRELDYETTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
               +D E  ++Y+L V A+DQ  +  P S    + I + D  D  P F    Y   + E 
Sbjct: 498  SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557

Query: 249  SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSH 308
              P T V  +TA D+DK     + Y I+SGN+   FA+D ++G + +   LD E      
Sbjct: 558  VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE---AER 614

Query: 309  GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP 368
             + L ++     D   P  +  T   +I V+DIND+ P F S+ + V++ E A +G ++ 
Sbjct: 615  EYALRIRA---QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV- 670

Query: 369  LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDR 426
            + IQ VD D   G N+  E  L G       ++P +  V   A   + V+ PLD E+V+ 
Sbjct: 671  IHIQAVDADH--GENARLEYSLTG-------VAPDTPFVINSATGWVSVSGPLDRESVEH 721

Query: 427  YDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLAT 485
            Y F + A +   P     A V +T+++ NDNRP F+   Y++ L E+  VGTSV++V A 
Sbjct: 722  YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781

Query: 486  DNDAGTFGEVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEET 543
            D DA +         +  +RF++      GL+ L   LDY+  + F L + A D    + 
Sbjct: 782  DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841

Query: 544  TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
               V IN+ D N + P FQ   Y  ++ E+ P  + +V + A+D+D   N +ITY +   
Sbjct: 842  C-YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED- 899

Query: 604  SAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD 663
                +     +    G I++  PLDYE        L + A D G P    T  V + V D
Sbjct: 900  ----NLPQFRIDADSGAITLQAPLDYE--DQVTYTLAITARDNGIPQKADTTYVEVMVND 953

Query: 664  ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLD-RSREYGQESIIYSLEGSTQFRIN 722
             NDN P F    Y   V E+     +VL ++ATD D  +    Q +     +G   F I 
Sbjct: 954  VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013

Query: 723  ARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP 782
              SG + T   LDRE  S Y L   AVD GV   +     ++ + + D+NDN P +    
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTP--VSIQVMVQDVNDNAPVFPAEE 1071

Query: 783  YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAML 840
            + + + E +   S V  + AVDPD G N  ++Y I   N  + + ++  +G++    A++
Sbjct: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELT---ALI 1128

Query: 841  DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----F 895
            D +    +EA     IVV  T     PL   S ATV V L+D NDN P   N       +
Sbjct: 1129 DLD----YEARQEYVIVVQATSA---PL--VSRATVHVRLVDQNDNSPVLNNFQILFNNY 1179

Query: 896  VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
            V+   +  P+G+ I ++ A D D  ++  + Y    G      ++N +SG +  + +LD 
Sbjct: 1180 VSNRSDTFPSGI-IGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDN 1236

Query: 956  ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE 991
             R     + V  +D      S T+   + V+ + +E
Sbjct: 1237 NRPLVASMLVTVTDG---LHSVTAQCVLRVVIITEE 1269



 Score =  320 bits (820), Expect = 1e-86
 Identities = 258/839 (30%), Positives = 394/839 (46%), Gaps = 67/839 (7%)

Query: 2064 DNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIH 2119
            +  P F        + EN   G +VL+V A D D+G  G LVY + A    R    F I 
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379

Query: 2120 LVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
              +G+IR   A +DRE  E + L V A D G+  LS T +V + + D ND  P F     
Sbjct: 380  PQSGLIRTA-AALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQY 438

Query: 2180 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
              ++ E+ E G  I  + A D D   N  L Y  VG  A             AF ++  +
Sbjct: 439  RETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAA------AAAAFEIDPRS 492

Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
            G +     ++RE + +YE+ +   D   +   RS +V   ++ + VLD NDN PQF    
Sbjct: 493  GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV---RVHITVLDENDNAPQFSE-- 547

Query: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
               Y+ ++ E   P T ++ V A D DK  NGLV Y ++     G+  + DS  G++   
Sbjct: 548  -KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI-DSLTGEIQVV 605

Query: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPV-YLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
              +D+E        +RA D G PP +    +  +++VDIND+ PIF    +Q +V E+ P
Sbjct: 606  APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAP 665

Query: 2417 VGTIILTVTATDADSGNFALIEYSLGD--GESKFAINPTTGDIYVLSSLDREKKDHYILT 2474
            +G  ++ + A DAD G  A +EYSL     ++ F IN  TG + V   LDRE  +HY   
Sbjct: 666  LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725

Query: 2475 ALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMAT 2534
              A+D+     S     S  V + VLDVND RP+F+  ++   + E+   GTSV+++ A 
Sbjct: 726  VEARDH----GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781

Query: 2535 DQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEP 2589
            D+D   N  ++Y + G       A       GLVT   PL   ++  F L + A+D    
Sbjct: 782  DRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-- 837

Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
             L     + + + D N +RPVF        + + E+ P+ S +  + A+D D G N  + 
Sbjct: 838  -LHDHCYVHINITDANTHRPVFQSAHYS--VSVNEDRPMGSTIVVISASDDDVGENARIT 894

Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
            Y         +   F ID  SG I     LD E Q  Y+L + A D G P   +T   ++
Sbjct: 895  YLL-----EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTY-VE 948

Query: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
            V + D++DN P FV     +  Y  L V E +P  T V  ++ A D D   N  V Y   
Sbjct: 949  VMVNDVNDNAPQFV-----ASHYTGL-VSEDAPPFTSVLQIS-ATDRDAHANGRVQYTFQ 1001

Query: 2770 AGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
             G + + +F ++P  G +  +R LDRE  +++     A  +R   P R P          
Sbjct: 1002 NGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-VDRGVPPLRTP---------- 1050

Query: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
                ++V+++D+ND  P F   E+   V  ++ VGS + Q+ A+D D G N+ + Y I+
Sbjct: 1051 --VSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIV 1107



 Score =  171 bits (433), Expect = 1e-41
 Identities = 136/392 (34%), Positives = 193/392 (49%), Gaps = 31/392 (7%)

Query: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL----EGPGVEAFHVDMDS 2562
            PQF +  + T V ENE AGT+V+ ++A D D G  G L YSL        +E F +D  S
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382

Query: 2563 GLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
            GL+ T   L  +S E+  L V A D G P L  TTM+ V V D ND+ PVF +      L
Sbjct: 383  GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442

Query: 2621 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNR--DWEFFIIDPISGLIQTAQR 2678
              RE +     + ++ ATD D   N  +RY F+     R      F IDP SGLI T+ R
Sbjct: 443  --RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR 500

Query: 2679 LDRESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
            +DRE    Y L++ ASD GQ P P      + + + D +DN P F      S +  +  V
Sbjct: 501  VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF------SEKRYVAQV 554

Query: 2738 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRERE 2796
             E     T+V  VT A D D+  N +V+Y I +GN   +F +    G + V+  LD E E
Sbjct: 555  REDVRPHTVVLRVT-ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613

Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
              ++  ++A    +  PP        L  +  L  ++VV  DIND  P F    +   V 
Sbjct: 614  REYALRIRAQD--AGRPP--------LSNNTGLASIQVV--DINDHIPIFVSTPFQVSVL 661

Query: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSILAI 2888
             +A +G  +I + A+DAD G N+ + YS+  +
Sbjct: 662  ENAPLGHSVIHIQAVDADHGENARLEYSLTGV 693



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 54/191 (28%), Positives = 81/191 (42%), Gaps = 23/191 (12%)

Query: 2730 PQYQLLT-VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN---FHLQPD-GC 2784
            PQY   T VPE+   GT V  V  A D D G    + Y +AA    ++   F + P  G 
Sbjct: 326  PQYNYQTLVPENEAAGTAVLRVV-AQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGL 384

Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
            +     LDRE        V A  + S   PR  + T+          V V + D ND  P
Sbjct: 385  IRTAAALDRESMERHYLRVTAQDHGS---PRLSATTM----------VAVTVADRNDHSP 431

Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDV--- 2901
             F +A+Y   +  + + G  ++Q+ A D D   N+ + Y  +     RA A  + ++   
Sbjct: 432  VFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPR 491

Query: 2902 -GQVFTMGSMD 2911
             G + T G +D
Sbjct: 492  SGLISTSGRVD 502



 Score = 33.9 bits (76), Expect = 2.8
 Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 8/73 (10%)

Query: 2844 PRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQ 2903
            P+F +  Y   V  +   G+ +++V+A D D G    + YS+ A+   R+L        +
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSL--------E 374

Query: 2904 VFTMGSMDGILRT 2916
            +F++    G++RT
Sbjct: 375  LFSIDPQSGLIRT 387


>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score =  360 bits (923), Expect = 2e-98
 Identities = 358/1253 (28%), Positives = 530/1253 (42%), Gaps = 136/1253 (10%)

Query: 413  IRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
            IR A  LD E  D Y F               +V+I + + ND+ P F      + + E 
Sbjct: 125  IRTARRLDRERRDHYSFVAATLLGA-----VVQVEIRVNDVNDHSPRFPLDSLQLDVSEL 179

Query: 473  VTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------- 513
               GT+    +A D DAG F    Y      D   L KD                     
Sbjct: 180  SPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSD---LPKDPAGPFFQLRYRTPGPLPSPLL 236

Query: 514  ----------LIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTF 561
                       ++L+ RLD E      L I A DGG    TG   V + VLD NDN P F
Sbjct: 237  PGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296

Query: 562  QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---------VSASAFGSYFDI 612
            ++D Y  A+RE+     ++ R+RATD D  PN  + YS+             A G     
Sbjct: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356

Query: 613  SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT-- 670
            ++ E  GV+ V RPLD E  +     L V A D G  P  +TV V+I V D NDN P   
Sbjct: 357  AVEELSGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414

Query: 671  --FSKPAYFVSVVENIMAGATVLFLNATDLDRSRE------------YGQESIIYSLEGS 716
              F        V E    G  V  ++ +D D   E             G  SI  SLEG 
Sbjct: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474

Query: 717  TQFRINARSGE-----ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771
                     G      +     LDRE++  Y L++ A D   G    +   T+ + + D+
Sbjct: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD--AGSPPLSTEETLLLRVADL 532

Query: 772  NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG------TLVYSIQPPN---- 821
            ND  P +    Y  ++ E   P + V  V A D D   +       T+V    P N    
Sbjct: 533  NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592

Query: 822  -----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
                         ++++S +G I T    LDRE  +  E +++ +      D G PPL A
Sbjct: 593  QSKMVHTAECGPSFAIDSESGAISTIRT-LDREVQEAVELKVVAQ------DLGEPPLSA 645

Query: 871  TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
            T   ++ V+  D+NDN+P F    + A + E  P G    QV A D D GL G + Y + 
Sbjct: 646  TCLVSITVD--DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703

Query: 931  VGMPRMD----FLINSSSGVVVTTTELDRER-IAEYQLRVVASDAGTPTKSSTSTLTIHV 985
             G    +    F I+   G +  + ++DRER  A Y L V A D G    S+ + + + +
Sbjct: 704  DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDL 761

Query: 986  LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045
             DVND  P F P+ Y  S+S++      ++ +  TD D G+   ++Y +  GNV   F++
Sbjct: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTI 821

Query: 1046 GYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQS 1105
                 ++   + L    +    L++ A D G  G      A V + +         F + 
Sbjct: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGG--GLTAVINADVTIHIFQTTLAPAEFERP 879

Query: 1106 SYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP 1165
             Y   V ED+PE   I  +KA +        ++YRI  G+ G  F IH   G + R  +P
Sbjct: 880  KYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTI-RTRKP 937

Query: 1166 LDRERNSSHVLIVEAYNHDLG--PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
            LD E     VL V+A    LG  P  SS  V + V D+ND  P F +     + + +T  
Sbjct: 938  LDHETQPVVVLTVQA---QLGSAPACSSTEVNITVMDVNDNHPAFLRTS-DEIRISQTTP 993

Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
             GT++ + +A DRDSG  GL+ Y I S   G F ID + G++     L    +    + +
Sbjct: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053

Query: 1284 SATDQAPPFNQGFCSVYITL-LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
             A DQ          + + +   E   +  F +  Y+  + E+L+  T++++ QA+ +  
Sbjct: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113

Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA---DDGGPKVD 1399
                +    +   +   A+F I   TG I ++   D E    Y   V A   +DG  +  
Sbjct: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173

Query: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV-ATVKAWDPDAGSNGQVVFSL 1458
            ST  V + V DENDNSP   F  D      E+ PV Q V   + A D D+G NGQ+++ L
Sbjct: 1174 STT-VIVRVWDENDNSP--TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230

Query: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518
             S       +    N + GE+     LDRE   H+ + V+ +DRG+PPR     + V++ 
Sbjct: 1231 LSDG-----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 1285

Query: 1519 DINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
            DINDN P           +V V E       V  V A D D G N+ ++Y ++
Sbjct: 1286 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338



 Score =  350 bits (897), Expect = 2e-95
 Identities = 365/1279 (28%), Positives = 548/1279 (42%), Gaps = 150/1279 (11%)

Query: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
            D  ++   G+I  +R LD E+  +       +        L + V V I V D ND+ P 
Sbjct: 115  DFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSPR 166

Query: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------------ 718
            F   +  + V E    G       A D D          ++S +G T             
Sbjct: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAG--------LFSTQGYTLVQPSDLPKDPAG 218

Query: 719  --FRINARSG------------------EITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758
              F++  R+                   ++     LDRE  + + L + A DGG    ++
Sbjct: 219  PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG--RPRR 276

Query: 759  TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI- 817
            TG+ +V + +LD NDN P ++   Y   + E   P ++V  V A D DLG NG + YS+ 
Sbjct: 277  TGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVR 336

Query: 818  --QPPN-----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
              Q P             ++++   +G +R     LDR      EA+   ++VV   D G
Sbjct: 337  ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP-LDR------EAQAWHQLVVEARDGG 389

Query: 865  RPPLKATSSATVFVNLLDLNDNDPTFQNLPF----VAEVLEGIPAGVSIYQVVAIDLD-- 918
              P  AT    V + +LD+NDN P    L      VA V EG   G  + +V   D D  
Sbjct: 390  AEPEVAT--VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447

Query: 919  ------------EGL-NGLVSYRMPVGMPRMDFLINSSSGVVVTTTE--LDRERIAEYQL 963
                         GL +G +S  +  G      L     GV     E  LDRE    Y+L
Sbjct: 448  WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507

Query: 964  RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
             +VA+DAG+P  S+  TL + V D+ND+ P F    Y  SVSE       V+W++ +D D
Sbjct: 508  LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567

Query: 1024 -------------------VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTA 1064
                                 L +  S  +        F++      + T+  LDRE   
Sbjct: 568  EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627

Query: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            A  L + A D G      + T  V +TV DVNDN PIF +  Y A++ E  P GH  LQ+
Sbjct: 628  AVELKVVAQDLGE--PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685

Query: 1125 KATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLIVE 1179
             A+DAD G +G + Y +  G         FRI   +G +    + +DRER+ +++ L+VE
Sbjct: 686  TASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLLVE 744

Query: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
            A   D G + +   V V +ED+ND  PVF    Y    + +    GT +I V ATD+DSG
Sbjct: 745  A--KDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYV-TSISDETQPGTEIINVLATDQDSG 801

Query: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCS 1298
              G V Y ++ G     F ID +TG+I     L +   T+  + VSA D           
Sbjct: 802  IYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD 861

Query: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQA 1358
            V I +        +F    Y   + E++   + I  V+A   + LN     F   +S   
Sbjct: 862  VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR--EPLNSSEPIFYRISSGDL 919

Query: 1359 KALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF 1418
               F I    G I  +  +D E      LTV A  G     S+ +V ITV+D NDN P F
Sbjct: 920  GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 979

Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
              TSD  + I +  P G  +   +A D D+G NG + +S+AS    G F I   + ++G 
Sbjct: 980  LRTSDE-IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAI---DRALGV 1034

Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVN 1538
            +F+   L   E     L + A D+G  P+    +L V I     +P        Y V V+
Sbjct: 1035 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVS 1094

Query: 1539 ENVGGGTAVVQVRATDRDIG---INSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRE 1595
            E++   T ++Q +A    +G     S L Y +        F +   +G I  R       
Sbjct: 1095 ESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 1152

Query: 1596 RQSF-YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1654
             Q++ + + A + ++G    + +T V V + DENDN+P F      + ++E P      +
Sbjct: 1153 TQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-I 1210

Query: 1655 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTAT 1714
              I A+D+D G NG + Y +++      F+++ + G +     LD E   G + + V  T
Sbjct: 1211 GKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDRE-HRGHHEMTVLVT 1267

Query: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP---FEVTEGQP-GPRVWTFLAHD 1770
            D+    S    +T  V V+V DINDN P FP+   G     +V EGQP    V T  A D
Sbjct: 1268 DRG---SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 1324

Query: 1771 RDSGPNGQVEYSIMDGDPL 1789
             D G N +V YS+    P+
Sbjct: 1325 PDEGNNAEVTYSVSSARPM 1343



 Score =  349 bits (896), Expect = 2e-95
 Identities = 361/1270 (28%), Positives = 551/1270 (43%), Gaps = 142/1270 (11%)

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW 778
            F ++  +G I T   LDRE +  Y  +   + G V          V I + D+ND+ P +
Sbjct: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV--------VQVEIRVNDVNDHSPRF 167

Query: 779  KDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI--------QPPNKFYSLNSTT 830
                  +++ E++PP +     VA DPD G   T  Y++         P   F+ L   T
Sbjct: 168  PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227

Query: 831  GKIRTTHAMLDRENP-DPHEAELMR----------KIVVSVTDCGRPPLKATSSATVFVN 879
                 +  +    +P +P +  L+R          ++ +   D GRP  + T   +V + 
Sbjct: 228  PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP--RRTGLLSVELR 285

Query: 880  LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM------ 933
            +LD NDN P F+   + A V E    G  + +V A D D G NG V Y +          
Sbjct: 286  VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGS 345

Query: 934  ------PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987
                      F +   SGVV     LDRE  A +QL V A D G   + +T  ++I VLD
Sbjct: 346  GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405

Query: 988  VNDETPT----FFPAVYNVSVSEDVPREFRVVWLNCTDND--------------VGL-NA 1028
            VND  P     F        VSE       V  ++ +D D              VGL + 
Sbjct: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465

Query: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVV--GLDRETTAAYMLILEAIDNG--PVGKRHTG 1084
             +S  + GG  D     G    V    V   LDRE+   Y L+L A D G  P+      
Sbjct: 466  SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE-- 523

Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR---- 1140
              T+ + V D+ND  P+F Q  Y+ASV E    G  ++ + A+DADE      W R    
Sbjct: 524  --TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581

Query: 1141 --------------ILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                          ++H    G +F I   +G +    R LDRE   +  L V A +   
Sbjct: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST-IRTLDREVQEAVELKVVAQDLGE 640

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
             P+ ++  V + V+D+ND  P+F +Q Y+   + E A +G   + V A+D DSG  G + 
Sbjct: 641  PPLSATCLVSITVDDVNDNEPIFWRQVYNAT-IAEHAPVGHCFLQVTASDADSGLYGFIE 699

Query: 1246 YRILSG-----AEGKFEIDESTGLIITVNYLDYE-TKTSYMMNVSATDQAPPFNQGFCSV 1299
            Y +  G     A   F ID   G I     +D E    +Y + V A D      Q F  V
Sbjct: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRV 759

Query: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK 1359
             +  +N  D    F+ ++Y  +I +    GTEI+ V A   D+    T  +         
Sbjct: 760  DLEDVN--DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVS 816

Query: 1360 ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP-----KVDSTVKVYITVLDEND- 1413
            +LF ID+ TG+I +   +   +    +L V A DGG        D T+ ++ T L   + 
Sbjct: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876

Query: 1414 NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473
              P++ F       +PED P+G    TVKA +P   S+  + + ++SG++ G F I   +
Sbjct: 877  ERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEPIFYRISSGDLGGKFSI---H 926

Query: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGY 1533
              +G +   +PLD E     +L V A   G+ P      + +T++D+NDN P        
Sbjct: 927  PRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRT-SD 984

Query: 1534 NVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPD 1593
             + +++    GTA+   RA DRD G N ++ Y I      + F +DR  G +    +   
Sbjct: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGA 1043

Query: 1594 RERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH--YEVLLDEGPDTLN 1651
             E++    L    ED+G    +A   V   ++++ +++P +   H  Y+V + E    + 
Sbjct: 1044 GEQREL-TLTLRAEDQGVHPQAALL-VLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM- 1100

Query: 1652 TSLITIQALDLDEGPN---GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
            T ++  QA  L  GP      + Y++        F I  + G I   ++ DYE S   Y 
Sbjct: 1101 TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYN 1157

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR--VWTF 1766
              V A    P        +TTV+V V D NDN PTF  D    F   E  P P+  +   
Sbjct: 1158 FRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV--LFLKVEESPVPQGVIGKI 1213

Query: 1767 LAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826
             A D DSG NGQ+ Y ++       F ++P  G L     V LDRE    + +T+   DR
Sbjct: 1214 TAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGEL--INWVALDREHRGHHEMTVLVTDR 1269

Query: 1827 GMPPLSSTMLVGIRVLDINDNDP----VLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
            G PP ++TM V + V DINDN P     L    +++ + E  PV+  V  V A D D G 
Sbjct: 1270 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329

Query: 1883 NARLTFNITA 1892
            NA +T+++++
Sbjct: 1330 NAEVTYSVSS 1339



 Score =  345 bits (884), Expect = 6e-94
 Identities = 366/1286 (28%), Positives = 556/1286 (43%), Gaps = 163/1286 (12%)

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1421
            F +   TG+I     +DRE+ D Y+       G     + V+V I V D ND+SPRF   
Sbjct: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLD 170

Query: 1422 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI-----AGAF--------- 1467
            S   + + E  P G       A DPDAG      ++L   +      AG F         
Sbjct: 171  S-LQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229

Query: 1468 ----EIVTTNDSIGE---VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520
                 ++  + S  E   + + R LDREE   + LQ+ A D G P R     +++ +LD 
Sbjct: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289

Query: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----- 1575
            NDNPPV E    Y  +V E+   G  V +VRATDRD+G N  + Y +       A     
Sbjct: 290  NDNPPVFEQD-EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348

Query: 1576 -------FRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
                   F ++ +SG +     P DRE Q+++ LV    D G     AT  V + ++D N
Sbjct: 349  ALGDAAYFAVEELSGVVRVW-RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407

Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTS------LITIQALDLDEG---------------PN 1667
            DN P     H   L + G   ++        +  +   D D                  +
Sbjct: 408  DNRPAI---HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464

Query: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCPILSHRLT 1725
            G+++ ++  G            GV     E  LD E S   Y L++ ATD     S  L+
Sbjct: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE-SRDLYELLLVATDAG---SPPLS 520

Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPN--------- 1776
            +  T+L+ V D+ND  P F + +          PG  V    A D D   +         
Sbjct: 521  TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580

Query: 1777 ---------GQVEYSIMDGDPLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826
                     G ++  ++     G  F I    G +   +   LDRE      L + A+D 
Sbjct: 581  VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT--LDREVQEAVELKVVAQDL 638

Query: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886
            G PPLS+T LV I V D+NDN+P+      N TI+E++PV      V ASDADSG    +
Sbjct: 639  GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFI 698

Query: 1887 TFNITAG----NRERAFFINATTGIVTVNRPLDRERIP-EYKLTISVKDNPENPRIARRD 1941
             +++  G       +AF I+   G + V++ +DRER P  Y L +  KD       A   
Sbjct: 699  EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQA--- 755

Query: 1942 YDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001
               + + L D NDNHP+F  STY   + + +  GT   ++N  +LA D D  IY  V Y+
Sbjct: 756  --FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT--EIIN--VLATDQDSGIYGTVAYE 809

Query: 2002 LL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL 2060
            L+ G  S LF I+S+TG++     + +         L L++ A+D G L +  +  +TI 
Sbjct: 810  LIPGNVSSLFTIDSTTGIIY----LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI- 864

Query: 2061 DDNDNRPTFSPATL-----TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
              +  + T +PA       T  + E+ P    +  V A  E    +  + YRI +G    
Sbjct: 865  --HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGG 921

Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
            +F IH   G IR     +D E Q    LTV A   G+ P   +  V I + D+ND+ P F
Sbjct: 922  KFSIHPRLGTIRT-RKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAF 979

Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
            L     + + ++  PGT +    A D D   N  + Y I               Q   FA
Sbjct: 980  LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS------------PQPGVFA 1027

Query: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
            ++   G + +   +         +TL   D     P+ ++ V    LTV V++  +++P 
Sbjct: 1028 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLV----LTV-VIEKREHSPS 1081

Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAA--VDPDKGLNGLVTYTLLDLVPPGYVQLEDSS 2350
            +    + Y +E + E  +P T ++   A  + P +  + L  Y+L   V      +   +
Sbjct: 1082 WTFEHLVYQVE-VSESLSPMTQMLQTQAHPLGPQRAASPL-RYSLEPSVDSAMFGIRPYT 1139

Query: 2351 AGKVIANRTVDYEEVHWLNFTVRA--SDNGSPPRAAEIPVYLEIVDINDNNPIF-DQPSY 2407
             G +   R  DYE     NF V A   ++G     +   V + + D NDN+P F     +
Sbjct: 1140 -GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS-TTVIVRVWDENDNSPTFLHDVLF 1197

Query: 2408 QEAVFEDVPVGTIILTVTATDADSG-NFALIEYSLGDGESKFAINPTTGDIYVLSSLDRE 2466
             +     VP G +I  +TA D DSG N  L+ + L DG+  F +NP TG++    +LDRE
Sbjct: 1198 LKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGELINWVALDRE 1255

Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK----PQFSTSVYENE 2522
             + H+ +T L  D      S  R  ++ V + V D+ND RP F +     +    V E +
Sbjct: 1256 HRGHHEMTVLVTDR----GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311

Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL 2548
            P    V T+ A D DEG N E+TYS+
Sbjct: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV 1337



 Score =  334 bits (856), Expect = 1e-90
 Identities = 347/1285 (27%), Positives = 549/1285 (42%), Gaps = 148/1285 (11%)

Query: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207
            ++F +H   G++ R  R LDRER   +  +          + + V+V + V D+ND +P 
Sbjct: 114  DDFHVHPDTGII-RTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPR 166

Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE-------------- 1253
            F      +L + E +  GT+  +  A D D+G      Y ++  ++              
Sbjct: 167  FPLDSL-QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225

Query: 1254 ------------GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
                        G     E   L++ +  LD E   ++ + + A D   P   G  SV +
Sbjct: 226  RTPGPLPSPLLPGSSSPLEPLDLVL-LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVEL 284

Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID-----------NLNQITYRF 1350
             +L+E D    F    Y AA+ E+   G E+ RV+A   D              Q+    
Sbjct: 285  RVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAG 344

Query: 1351 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD-STVKVYITVL 1409
            +   +    A F ++ ++GV+ V   +DRE   ++ L V A DGG + + +TV+V I VL
Sbjct: 345  SGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL 404

Query: 1410 DENDNSPRFD---FTSDSAVSIPEDCPVGQRVATVKA------WDPDAGSNGQVVFSLAS 1460
            D NDN P       T      + E    G  VA V        W+ +  + G++   L  
Sbjct: 405  DVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464

Query: 1461 GNIAGAFE------IVTTNDSIGEVF--VARPLDREELDHYILQVVASDRGTPPRKKDHI 1512
            G+I+ + E       +      G  F  V  PLDRE  D Y L +VA+D G+PP   +  
Sbjct: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524

Query: 1513 LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD---------------- 1556
            L + + D+ND PP+      Y  SV+E    GT V+ V A+D D                
Sbjct: 525  LLLRVADLNDQPPLFSQQH-YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583

Query: 1557 ---IGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT 1613
                 + S+ S  +       +F +D  SG I+T     DRE Q    L    +D G P 
Sbjct: 584  SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPP 642

Query: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
            LSAT  V +T+ D NDN P+F +  Y   + E    +    + + A D D G  G + Y+
Sbjct: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAP-VGHCFLQVTASDADSGLYGFIEYS 701

Query: 1674 IVAGNIV----NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
            +  G +       FRID H G I  ++++D E     Y L+V A D        L++   
Sbjct: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD-----GGGLSAQAF 756

Query: 1730 VLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDP 1788
            V V++ D+NDN P F P  Y       E QPG  +   LA D+DSG  G V Y ++ G+ 
Sbjct: 757  VRVDLEDVNDNHPVFNPSTYVTSIS-DETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815

Query: 1789 LGEFVISPVEGVLRVRKDVE-LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDN 1847
               F I    G++ +   +  L+  T++   L + A+D G         V I +      
Sbjct: 816  SSLFTIDSTTGIIYLTLPLSHLESTTLS---LMVSAQDGGGLTAVINADVTIHIFQTTLA 872

Query: 1848 DPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGI 1907
                        + E+ P  S +  V A +  +     + + I++G+    F I+   G 
Sbjct: 873  PAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGT 931

Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
            +   +PLD E  P   LT+  +     P  +  + ++ ++   D NDNHP F +++ +  
Sbjct: 932  IRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVM---DVNDNHPAFLRTSDEIR 987

Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
            + + +P GT L +      A D D     ++ Y +   Q G+F I+ + GV+ +   +  
Sbjct: 988  ISQTTPPGTALYLAR----AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL-- 1041

Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITI-LDDNDNRP--TFSPATLTVHLLENCPP 2084
               A     L L L AED G+    A L++T+ ++  ++ P  TF      V + E+  P
Sbjct: 1042 --GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 1099

Query: 2085 GFSVLQVTATD-EDSGLNGELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRL 2142
               +LQ  A           L Y +E       F I   TG I +     D E  ++Y  
Sbjct: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL-RRQFDYESTQTYNF 1158

Query: 2143 TVVA---TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
             V A    D     +S T IV +   D ND+ P FL+ +  + V ES  P  VI  ITAI
Sbjct: 1159 RVFAWIPEDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAI 1216

Query: 2200 DHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257
            D D   N +L Y ++             +    F +N NTG ++    ++RE    +E+T
Sbjct: 1217 DMDSGKNGQLLYFLL-------------SDGKFFKMNPNTGELINWVALDREHRGHHEMT 1263

Query: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF--GITYYMERILEGATPGTTL 2315
            + V D  S  P R+ ++    + V+V D+NDN P F     G   ++ ++LEG      +
Sbjct: 1264 VLVTDRGS--PPRNATMA---VYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLV 1317

Query: 2316 IAVAAVDPDKGLNGLVTYTLLDLVP 2340
              V A DPD+G N  VTY++    P
Sbjct: 1318 TTVFAKDPDEGNNAEVTYSVSSARP 1342



 Score =  325 bits (833), Expect = 5e-88
 Identities = 365/1341 (27%), Positives = 550/1341 (41%), Gaps = 174/1341 (12%)

Query: 1643 LDEG--PDTLNTSLIT-IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
            +DEG  PDTL   +   + A    EG    ++       +++ F +    G+I  A+ LD
Sbjct: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132

Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQ 1758
             E     Y+ +             L +   V + VND+ND+ P FP D     +V+E   
Sbjct: 133  RE-RRDHYSFVAATL---------LGAVVQVEIRVNDVNDHSPRFPLD-SLQLDVSELSP 181

Query: 1759 PGPRVWTFLAHDRDSGPNGQVEYSIMDG-----DPLGEFV-------------------- 1793
            PG      +AHD D+G      Y+++       DP G F                     
Sbjct: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241

Query: 1794 -ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852
             + P++ VL  R    LDRE  A + L I A D G P  +  + V +RVLD NDN PV  
Sbjct: 242  PLEPLDLVLLRR----LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFE 297

Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA------------FF 1900
                   + E++   + V  V A+D D G N  + +++ A     A            F 
Sbjct: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357

Query: 1901 INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP--- 1957
            +   +G+V V RPLDRE    ++L +  +D    P +A     + ++   D NDN P   
Sbjct: 358  VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL---DVNDNRPAIH 414

Query: 1958 -LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL---LGAQSGLFDIN 2013
             LF      A V E +  G  +  ++  +   D D +     T +L   LG  S    + 
Sbjct: 415  VLFLTEGGVARVSEGARPGDYVARVS--VSDADGDWEKEDEATGELGVGLGDGSISLSLE 472

Query: 2014 SSTGVVTVRSGVI-----------IDREAFSPPILELLLLAEDIGL--LNSTAHLLITIL 2060
               G   +  G             +DRE  S  + ELLL+A D G   L++   LL+ + 
Sbjct: 473  GGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLRVA 530

Query: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG--------------------- 2099
            D ND  P FS       + E   PG  V+ V+A+D D                       
Sbjct: 531  DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590

Query: 2100 -LNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158
             L  ++V+  E G    F I   +G I     T+DRE QE+  L VVA D G  PLS T 
Sbjct: 591  SLQSKMVHTAECGPS--FAIDSESGAISTIR-TLDREVQEAVELKVVAQDLGEPPLSATC 647

Query: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218
            +V+I +DD+ND+ P F   +   ++ E A  G     +TA D D        + G +   
Sbjct: 648  LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG------LYGFIEYS 701

Query: 2219 DTDRLVPNQE-DAFAVNINTGSVMVKSPMNREL-VATYEVTLSVIDNASDLPERSVSVPN 2276
              D  +  +   AF ++ + G + V   ++RE   ATY++ +   D      +       
Sbjct: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ------- 754

Query: 2277 AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL 2336
            A + V++ DVNDN P F P   + Y+  I +   PGT +I V A D D G+ G V Y L+
Sbjct: 755  AFVRVDLEDVNDNHPVFNP---STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 811

Query: 2337 DLVPPGYVQ---LEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
                PG V      DS+ G +     + + E   L+  V A D G         V + I 
Sbjct: 812  ----PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867

Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDA-DSGNFALIEYSLGDGESKFAINP 2452
                    F++P Y   V+EDVP  + I TV A +  +S        S GD   KF+I+P
Sbjct: 868  QTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927

Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
              G I     LD E +   +LT  A+       S     S +V I V+DVND  P F + 
Sbjct: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRT 982

Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ 2572
                 + +  P GT++    A D+D G NG + YS+  P    F +D   G++     L 
Sbjct: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLG 1042

Query: 2573 SYE--KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
            + E  + +LT+ A D G  P     ++L  VI+  ++ P +        + + E +   +
Sbjct: 1043 AGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMT 1101

Query: 2631 NVYEVYATD-KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
             + +  A     +     +RYS   +    D   F I P +G I   ++ D ES   Y+ 
Sbjct: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158

Query: 2690 ILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGN 2749
             + A              + V + D +DN P F+           L V E      ++G 
Sbjct: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGK 1212

Query: 2750 VTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSN 2808
            +T A+D D G N  + YF+   ++ K F + P+ G L+    LDRE        V  +  
Sbjct: 1213 IT-AIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269

Query: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA----EYTAGVATDAKVGSE 2864
             S  PPR  +             V V + DIND  P F +     E    V     V   
Sbjct: 1270 GS--PPRNAT-----------MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316

Query: 2865 LIQVLALDADIGNNSLVFYSI 2885
            +  V A D D GNN+ V YS+
Sbjct: 1317 VTTVFAKDPDEGNNAEVTYSV 1337



 Score =  323 bits (827), Expect = 2e-87
 Identities = 359/1281 (28%), Positives = 544/1281 (42%), Gaps = 153/1281 (11%)

Query: 824  YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDL 883
            + ++  TG IRT    LDRE  D +         V+ T  G       +   V + + D+
Sbjct: 116  FHVHPDTGIIRTARR-LDRERRDHYS-------FVAATLLG-------AVVQVEIRVNDV 160

Query: 884  NDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMPR------ 935
            ND+ P F       +V E  P G +    VA D D GL     Y +  P  +P+      
Sbjct: 161  NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPF 220

Query: 936  ------------MDFLINSSSGV----VVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979
                           L  SSS +    +V    LDRE  A ++L++ A D G P ++   
Sbjct: 221  FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLL 280

Query: 980  TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
            ++ + VLD ND  P F    Y  +V ED      V  +  TD D+G N  + Y +    V
Sbjct: 281  SVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340

Query: 1040 DGK------------FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
             G             F+V     VVR    LDRE  A + L++EA D G   +    T  
Sbjct: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVR 398

Query: 1088 VFVTVLDVNDNRP----IFLQSSYEASVPEDIPEGHSILQLKATDAD---------EGEF 1134
            V + VLDVNDNRP    +FL     A V E    G  + ++  +DAD          GE 
Sbjct: 399  VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458

Query: 1135 GRVWYRILHGNHGNNFRIHVSNG---LLMRGP---------RPLDRERNSSHVLIVEAYN 1182
            G     +  G+   +  +    G   LL  GP          PLDRE    + L++ A +
Sbjct: 459  G-----VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513

Query: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD--SGD 1240
                P+ +   +++ V D+ND+ P+F+QQ Y +  + E A  GT V+ V A+D D    D
Sbjct: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHY-KASVSEAAAPGTVVMWVSASDADEAGSD 572

Query: 1241 GGLVNYRI--------LSGAEGK----------FEIDESTGLIITVNYLDYETKTSYMMN 1282
               + Y +        L   + K          F ID  +G I T+  LD E + +  + 
Sbjct: 573  HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632

Query: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
            V A D   P     C V IT+ +  D    F    Y A I E+  +G   ++V A   D+
Sbjct: 633  VVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS 692

Query: 1343 --LNQITYR-FNAYTSTQAKALFKIDAITGVITVQGLVDREKGD-FYTLTVVADDGGPKV 1398
                 I Y  ++ + S +A   F+ID   G I V   +DRE+    Y L V A DGG  +
Sbjct: 693  GLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-GL 751

Query: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSL 1458
             +   V + + D NDN P F+  S    SI ++   G  +  V A D D+G  G V + L
Sbjct: 752  SAQAFVRVDLEDVNDNHPVFN-PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 810

Query: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRG--TPPRKKD---HIL 1513
              GN++  F I +T    G +++  PL   E     L V A D G  T     D   HI 
Sbjct: 811  IPGNVSSLFTIDSTT---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
            Q T+      P   E P  Y   V E+V   + +  V+A +  +  +  + Y I+ G+  
Sbjct: 868  QTTLA-----PAEFERP-KYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG 920

Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE-GTPTLSATTHVYVTIVDENDNAP 1632
              F +    G I TR  P D E Q    +V TV+ + G+    ++T V +T++D NDN P
Sbjct: 921  GKFSIHPRLGTIRTR-KPLDHETQPV--VVLTVQAQLGSAPACSSTEVNITVMDVNDNHP 977

Query: 1633 MFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVI 1692
             F +   E+ + +      T+L   +A D D G NG + Y+I A      F IDR +GV+
Sbjct: 978  AFLRTSDEIRISQTTPP-GTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVL 1035

Query: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY-EGP 1751
                 L         TL + A DQ         +   VL  V +  ++ P++  ++    
Sbjct: 1036 FLNGSLGAG-EQRELTLTLRAEDQ----GVHPQAALLVLTVVIEKREHSPSWTFEHLVYQ 1090

Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPN---GQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE 1808
             EV+E    P            GP      + YS+        F I P  G + +R+  +
Sbjct: 1091 VEVSESL-SPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR--Q 1147

Query: 1809 LDRETIAFYNLTICA---RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865
             D E+   YN  + A    D  +  +S+T++V  RV D NDN P  L+  + + + E+  
Sbjct: 1148 FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV--RVWDENDNSPTFLHDVLFLKVEESPV 1205

Query: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLT 1925
                +  + A D DSG N +L + + +    + F +N  TG +     LDRE    +++T
Sbjct: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMT 1263

Query: 1926 ISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPI 1985
            + V D    PR A      + + ++D NDN P F +     E+      G P+ +L   +
Sbjct: 1264 VLVTDRGSPPRNATM---AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320

Query: 1986 LALDADQDIYAVVTYQLLGAQ 2006
             A D D+   A VTY +  A+
Sbjct: 1321 FAKDPDEGNNAEVTYSVSSAR 1341



 Score =  318 bits (815), Expect = 6e-86
 Identities = 356/1318 (27%), Positives = 561/1318 (42%), Gaps = 151/1318 (11%)

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI----SGVLTLNGLL 299
            ++ E  PP T V  I A      +  G G+ +   + +S    D+     +G++     L
Sbjct: 72   SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRL 131

Query: 300  DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
            DRE   +      T+ G  +  +             I V D+ND++P F      + ++E
Sbjct: 132  DRERRDHYSFVAATLLGAVVQVE-------------IRVNDVNDHSPRFPLDSLQLDVSE 178

Query: 360  LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA-DIRIRVA-- 416
            L+  G A  L    V  D + GL S     LV  +       P    G    +R R    
Sbjct: 179  LSPPGTAFRL---PVAHDPDAGLFSTQGYTLVQPSD-----LPKDPAGPFFQLRYRTPGP 230

Query: 417  -------------IPLDYETVDRYDFDLFANESV---------PDHVGYAKVKITLINEN 454
                          PLD   + R D +  A   +         P   G   V++ +++EN
Sbjct: 231  LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290

Query: 455  DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS-------------- 500
            DN P+F Q  Y  ++ E+   G  V  V ATD D G  G V Y                 
Sbjct: 291  DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350

Query: 501  DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNV 558
             D   F++++ +G++ +   LD E      L + ARDGG E    T RV I VLDVNDN 
Sbjct: 351  GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410

Query: 559  PT----FQKDAYVGALRENEPSVTQLVRLRATDEDSP--PNNQITYSI--------VSAS 604
            P     F  +  V  + E       + R+  +D D      ++ T  +        +S S
Sbjct: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470

Query: 605  AFGSYFDISLYEGY--GV--ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
              G   D +L  G   GV  + V  PLD E  S  L  L ++A DAG+PPL++   + + 
Sbjct: 471  LEGGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLR 528

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG--------------- 705
            V D ND PP FS+  Y  SV E    G  V++++A+D D +                   
Sbjct: 529  VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588

Query: 706  ----QESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI 761
                Q  ++++ E    F I++ SG I+T   LDRE +    L V A D  +G    +  
Sbjct: 589  LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD--LGEPPLSAT 646

Query: 762  ATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---- 817
              V+IT+ D+NDN P +    Y   + E  P       V A D D G  G + YS+    
Sbjct: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706

Query: 818  ---QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
               + P  F  ++   G+I  +   +DRE  DP   +L+    V   D G      ++ A
Sbjct: 707  LSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATYDLL----VEAKDGGG----LSAQA 755

Query: 875  TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
             V V+L D+NDN P F    +V  + +    G  I  V+A D D G+ G V+Y +  G  
Sbjct: 756  FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815

Query: 935  RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPT 994
               F I+S++G++  T  L         L V A D G  T    + +TIH+         
Sbjct: 816  SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875

Query: 995  FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1054
            F    Y   V EDVP +  +  +   +  +  +  + Y I+ G++ GKFS+  R   +RT
Sbjct: 876  FERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934

Query: 1055 VVGLDRETTAAYMLILEA-IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPE 1113
               LD ET    +L ++A + + P       +  V +TV+DVNDN P FL++S E  + +
Sbjct: 935  RKPLDHETQPVVVLTVQAQLGSAPA----CSSTEVNITVMDVNDNHPAFLRTSDEIRISQ 990

Query: 1114 DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNS 1172
              P G ++   +A D D G  G + Y I     G  F I  + G+L + G      +R  
Sbjct: 991  TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQREL 1049

Query: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT-QQQYSRLGLRETAGIGTSVIVV 1231
            +  L + A +  + P ++++ V+  V +  + +P +T +    ++ + E+    T ++  
Sbjct: 1050 T--LTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106

Query: 1232 QATD-RDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA 1289
            QA           + Y +    +   F I   TG I      DYE+  +Y   V A    
Sbjct: 1107 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166

Query: 1290 PPFNQGF-CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQI 1346
              F Q    +V + + +E D +  F +      + E+      I ++ A  +D+    Q+
Sbjct: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226

Query: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVY 1405
             Y    +  +  K  FK++  TG +     +DRE    + +TV V D G P  ++T+ VY
Sbjct: 1227 LY----FLLSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281

Query: 1406 ITVLDENDNSPRFDFT---SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
            ++V D NDN P F       +  V + E  PV   V TV A DPD G+N +V +S++S
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339



 Score =  292 bits (747), Expect = 4e-78
 Identities = 300/1136 (26%), Positives = 467/1136 (41%), Gaps = 131/1136 (11%)

Query: 89   LRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
            L + LDRE  +   ++    D       G+++  V ++V D NDN P F    Y   + E
Sbjct: 250  LLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS--VELRVLDENDNPPVFEQDEYRAAVRE 307

Query: 144  NTPVGTPIFIVNATDPDLGAGGSVLYSFQP--------------PSQFFAIDSARGIVTV 189
            +   G  +  V ATD DLG  G V YS +                + +FA++   G+V V
Sbjct: 308  DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367

Query: 190  IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNI 245
             R LD E    +QL V A D      ++T+  ++I + DV D  P    +F+       +
Sbjct: 368  WRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDNRPAIHVLFLTEGGVARV 426

Query: 246  YEHSPPGTTVRIITAIDQDKGRPR--------GIG----------------YTIVSGNTN 281
             E + PG  V  ++  D D    +        G+G                + ++ G   
Sbjct: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486

Query: 282  SIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVID 340
             +F        L + G LDRE+  LY    + T  G+           +   T  + V D
Sbjct: 487  GVF-------FLCVEGPLDRESRDLYELLLVATDAGS--------PPLSTEETLLLRVAD 531

Query: 341  INDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS----- 395
            +ND  P F+   Y  +++E A  G  + +++   D DE  G +  +  Y V   S     
Sbjct: 532  LNDQPPLFSQQHYKASVSEAAAPG-TVVMWVSASDADE-AGSDHAWLRYTVVQLSAPCNL 589

Query: 396  --------HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKV 446
                    H     P+         I     LD E  +  +  + A +   P       V
Sbjct: 590  GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649

Query: 447  KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD---- 502
             IT+ + NDN PIF + +YN ++ E+  VG   L V A+D D+G +G + Y   D     
Sbjct: 650  SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709

Query: 503  --PDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRINVLDVNDNVP 559
              P  F +D   G I +   +D E     + L + A+DGGG      VR+++ DVNDN P
Sbjct: 710  EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769

Query: 560  TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
             F    YV ++ +     T+++ + ATD+DS     + Y ++  +   S F I      G
Sbjct: 770  VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV-SSLFTID--STTG 826

Query: 620  VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679
            +I ++ PL +  + +  + L V A D G         VTI +F     P  F +P Y   
Sbjct: 827  IIYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884

Query: 680  VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDR 736
            V E++   + +  + A    R      E I Y +       +F I+ R G I T   LD 
Sbjct: 885  VYEDVPEDSPIGTVKA----REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 940

Query: 737  ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796
            ET+   +L V+A  G       T    VNIT++D+NDNHP +      I + + TPP + 
Sbjct: 941  ETQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997

Query: 797  VTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
            +    A D D G NG + YSI  P    ++++   G +      L+       + EL   
Sbjct: 998  LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVL-----FLNGSLGAGEQREL--T 1050

Query: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVV 913
            + +   D G  P  A    TV   +++  ++ P  TF++L +  EV E +     + Q  
Sbjct: 1051 LTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 1107

Query: 914  AIDL-DEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDA 970
            A  L  +     + Y +   +    F I   +G +    + D E    Y  RV A   + 
Sbjct: 1108 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167

Query: 971  GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
            G     ST T+ + V D ND +PTF   V  + V E    +  +  +   D D G N +L
Sbjct: 1168 GFLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226

Query: 1031 SYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
             YF+     DGK F +      +   V LDRE    + + +   D G        T  V+
Sbjct: 1227 LYFLLS---DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRG--SPPRNATMAVY 1281

Query: 1090 VTVLDVNDNRPIFLQ----SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141
            V+V D+NDNRP F Q          V E  P    +  + A D DEG    V Y +
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337



 Score =  284 bits (726), Expect = 1e-75
 Identities = 346/1296 (26%), Positives = 552/1296 (42%), Gaps = 160/1296 (12%)

Query: 56   LAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115
            L++D D+ PL+           F V PDTG++   + LDRE +  ++  F  +   G + 
Sbjct: 103  LSEDSDDSPLLDD---------FHVHPDTGIIRTARRLDRERRDHYS--FVAATLLGAVV 151

Query: 116  RKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 175
            + V I+V DVND++P F      + + E +P GT   +  A DPD G   +  Y+   PS
Sbjct: 152  Q-VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210

Query: 176  Q--------FFAI--------------DSARGI----VTVIRELDYETTQAYQLTVNATD 209
                     FF +               S+  +    + ++R LD E   A++L + A D
Sbjct: 211  DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270

Query: 210  QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
              + R  + L ++ + + D  D  P+F    Y   + E + PG  V  + A D+D G   
Sbjct: 271  GGRPR-RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNG 329

Query: 270  GIGYTI----VSG--------NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
             + Y++    V G           + FA++ +SGV+ +   LDRE   + H  ++  +  
Sbjct: 330  FVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAW-HQLVVEAR-- 386

Query: 318  ELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SSEYSVA-ITELAQVG-FALPLFIQ 372
                D        T   +I V+D+NDN P  +    +E  VA ++E A+ G +   + + 
Sbjct: 387  ----DGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVS 442

Query: 373  VVDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIR-----------VAIPLD 420
              D D      +  E+ + +G+ S    IS +   G+ D  +            V  PLD
Sbjct: 443  DADGDWEKEDEATGELGVGLGDGS----ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLD 498

Query: 421  YETVDRYDFDLFANESVPDHVGYAKVKITLINE-NDNRPIFSQPLYNISLYENVTVGTSV 479
             E+ D Y+  L A ++    +   +  +  + + ND  P+FSQ  Y  S+ E    GT V
Sbjct: 499  RESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVV 558

Query: 480  LTVLATDND---------------------AGTFGEVSYFFSDDPDRFSLDKDTGLIMLI 518
            + V A+D D                      G+        ++    F++D ++G I  I
Sbjct: 559  MWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTI 618

Query: 519  ARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPS 576
              LD E+ +   L ++A+D G      T  V I V DVNDN P F +  Y   + E+ P 
Sbjct: 619  RTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPV 678

Query: 577  VTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-----FDISLYEGYGVISVSRPLDYEQ 631
                +++ A+D DS     I YS+     F SY     F I  ++G   I VS+ +D E+
Sbjct: 679  GHCFLQVTASDADSGLYGFIEYSLY--DGFLSYEAPQAFRIDPHDGQ--ICVSQDIDRER 734

Query: 632  ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
                   L V A D G   L++   V +++ D NDN P F+   Y  S+ +    G  ++
Sbjct: 735  -DPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791

Query: 692  FLNATDLDRSREYGQESIIYSL---EGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
             + ATD D S  YG  ++ Y L     S+ F I++ +G I  T  L     +   L+V A
Sbjct: 792  NVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSA 848

Query: 749  VDGGVGHNQKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPD 806
             DGG      T +   ++T+        P   + P Y  LV E  P DS + TV A +P 
Sbjct: 849  QDGG----GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP- 903

Query: 807  LGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
            L  +  + Y I   +    +S++   G IRT         P  HE +    +VV      
Sbjct: 904  LNSSEPIFYRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQ 953

Query: 865  RPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGL 924
                 A SS  V + ++D+NDN P F        + +  P G ++Y   A D D G NGL
Sbjct: 954  LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013

Query: 925  VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
            + Y +    P + F I+ + GV+     L      E  L + A D G   +++   LT+ 
Sbjct: 1014 IRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071

Query: 985  VLDVNDETP--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG---LNAELSYFITGGNV 1039
            V++  + +P  TF   VY V VSE +    ++  L    + +G     + L Y +     
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVD 1129

Query: 1040 DGKFSVGYRDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
               F +      +      D E+T  Y   +   I     G     + TV V V D NDN
Sbjct: 1130 SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED--GFLQNVSTTVIVRVWDENDN 1187

Query: 1099 RPIFLQSSYEASVPED-IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157
             P FL       V E  +P+G  I ++ A D D G+ G++ Y +L  + G  F+++ + G
Sbjct: 1188 SPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTG 1244

Query: 1158 LLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ---QQYS 1214
             L+     LDRE    H + V   +    P  +++ V V V DIND  P F Q    +  
Sbjct: 1245 ELINWV-ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 1303

Query: 1215 RLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILS 1250
             + + E   +   V  V A D D G+   V Y + S
Sbjct: 1304 HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339



 Score =  272 bits (696), Expect = 4e-72
 Identities = 298/1103 (27%), Positives = 474/1103 (42%), Gaps = 137/1103 (12%)

Query: 42   ISEDTPVGSSVTQLLAQDMDNDPLVF-----------------GVSGEEASRFFAVEPDT 84
            + ED   G+ V ++ A D D  P  F                 G  G+ A  +FAVE  +
Sbjct: 305  VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA--YFAVEELS 362

Query: 85   GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFH----NQPY 137
            GVV + +PLDRE ++   +     D      V T +V+I V DVNDN P  H     +  
Sbjct: 363  GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGG 422

Query: 138  SVRIPENTPVGTPIFIVNATDPD------------LGAG---GSVLYSFQPPSQFFAI-- 180
              R+ E    G  +  V+ +D D            LG G   GS+  S +     FA+  
Sbjct: 423  VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLP 482

Query: 181  DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
                G+  +  E  LD E+   Y+L + ATD   + PLST   L + + D+ D  P+F  
Sbjct: 483  GGPPGVFFLCVEGPLDRESRDLYELLLVATDAG-SPPLSTEETLLLRVADLNDQPPLFSQ 541

Query: 239  LPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIV-----------------SGN 279
              Y  ++ E + PGT V  ++A D D+       + YT+V                 +  
Sbjct: 542  QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601

Query: 280  TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339
                FA+D  SG ++    LDRE         L V   +L +       + T   +I V 
Sbjct: 602  CGPSFAIDSESGAISTIRTLDRE---VQEAVELKVVAQDLGE----PPLSATCLVSITVD 654

Query: 340  DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL-----NSMFEVYLVGNN 394
            D+NDN P F    Y+  I E A VG     F+QV   D + GL      S+++ +L    
Sbjct: 655  DVNDNEPIFWRQVYNATIAEHAPVGHC---FLQVTASDADSGLYGFIEYSLYDGFLSYEA 711

Query: 395  SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV-GYAKVKITLINE 453
               F I P       D +I V+  +D E  D   +DL         +   A V++ L + 
Sbjct: 712  PQAFRIDP------HDGQICVSQDIDRER-DPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764

Query: 454  NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKD 511
            NDN P+F+   Y  S+ +    GT ++ VLATD D+G +G V+Y     +    F++D  
Sbjct: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824

Query: 512  TGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQKDAYVGA 569
            TG+I L   L +      +L + A+DGGG        V I++         F++  Y   
Sbjct: 825  TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884

Query: 570  LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY 629
            + E+ P  + +  ++A  E    +  I Y I S    G +   S++   G I   +PLD+
Sbjct: 885  VYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKF---SIHPRLGTIRTRKPLDH 940

Query: 630  EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
            E  +  ++ LTV A   G+ P  S+  V I V D NDN P F + +  + + +    G  
Sbjct: 941  E--TQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997

Query: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIV 746
            +    A D    R+ G+  +I     S Q   F I+   G +     L    + E  L +
Sbjct: 998  LYLARAED----RDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053

Query: 747  RAVDGGVGHNQKTGIATVNITLLDINDNHPTW--KDAPYYINLVEMTPPDSDV--TTVVA 802
            RA D GV       + TV   +++  ++ P+W  +   Y + + E   P + +  T    
Sbjct: 1054 RAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110

Query: 803  VDPDLGENGTLVYSIQP--PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSV 860
            + P    +  L YS++P   +  + +   TG I       D E+   +      ++   +
Sbjct: 1111 LGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWI-YLRRQFDYESTQTYNF----RVFAWI 1164

Query: 861  TDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEG-IPAGVSIYQVVAIDLDE 919
             + G        S TV V + D NDN PTF +     +V E  +P GV I ++ AID+D 
Sbjct: 1165 PEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDS 1220

Query: 920  GLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979
            G NG + Y +        F +N ++G ++    LDRE    +++ V+ +D G+P +++T 
Sbjct: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278

Query: 980  TLTIHVLDVNDETPTFFPAV-----YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
             + + V D+ND  P FFP        +V V E  P    V  +   D D G NAE++Y +
Sbjct: 1279 AVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337

Query: 1035 TGGN---VDGKFSVGYRDAVVRT 1054
            +      + GK + G +    +T
Sbjct: 1338 SSARPMPLKGKTAFGKQSCKKQT 1360



 Score =  261 bits (666), Expect = 1e-68
 Identities = 316/1219 (25%), Positives = 504/1219 (41%), Gaps = 150/1219 (12%)

Query: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825
            FL+ D D  P             L +F + P  G++R  +   LDRE    Y+       
Sbjct: 102  FLSEDSDDSPL------------LDDFHVHPDTGIIRTAR--RLDRERRDHYSFVAATL- 146

Query: 1826 RGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNAR 1885
                 L + + V IRV D+ND+ P      + + +SE SP  +     +A D D+G  + 
Sbjct: 147  -----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFST 201

Query: 1886 LTFNI--------------------TAGNRERAFFINATTGIVTVN----RPLDRERIPE 1921
              + +                    T G         +++ +  ++    R LDRE    
Sbjct: 202  QGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAA 261

Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
            ++L I   D     R      +L ++   DENDN P+F +  Y+A V E++  G  +  +
Sbjct: 262  HRLQIEAWDGGRPRRTGLLSVELRVL---DENDNPPVFEQDEYRAAVREDAQPGAEVCRV 318

Query: 1982 NGPILALDADQDI-YAVVTYQLLGAQSG--------LFDINSSTGVVTVRSGVIIDREAF 2032
                  L  +  + Y+V   Q+ GA SG         F +   +GVV V     +DREA 
Sbjct: 319  RATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP--LDREAQ 376

Query: 2033 SPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFSPATLT----VHLLENCPPGF 2086
            +    +L++ A D G     +T  + I +LD NDNRP      LT      + E   PG 
Sbjct: 377  AWH--QLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGD 434

Query: 2087 SVLQVTATDEDS--------------GL-NGELVYRIEAGAQDRFLIHL-VTGVIRVG-N 2129
             V +V+ +D D               GL +G +   +E G  D  L+     GV  +   
Sbjct: 435  YVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVE 494

Query: 2130 ATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189
              +DRE ++ Y L +VATD G+ PLS    + + + D+ND  P F       SV E+A P
Sbjct: 495  GPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAP 554

Query: 2190 GTVIANITAIDHDL----NPKLEYHIVGIVAKDDT----DRLVPNQE--DAFAVNINTGS 2239
            GTV+  ++A D D     +  L Y +V + A  +      ++V   E   +FA++  +G+
Sbjct: 555  GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA 614

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            +     ++RE+    E  L V+  A DL E  +S     +++ V DVNDN P F      
Sbjct: 615  ISTIRTLDREVQEAVE--LKVV--AQDLGEPPLSA-TCLVSITVDDVNDNEPIFWR---Q 666

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-------DSSAG 2352
             Y   I E A  G   + V A D D GL G + Y+L D    G++  E       D   G
Sbjct: 667  VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD----GFLSYEAPQAFRIDPHDG 722

Query: 2353 KVIANRTVDYE-EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAV 2411
            ++  ++ +D E +    +  V A D G     A + V LE  D+NDN+P+F+  +Y  ++
Sbjct: 723  QICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSI 780

Query: 2412 FEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKD 2469
             ++   GT I+ V ATD DSG +  + Y L  G+  S F I+ TTG IY+   L   +  
Sbjct: 781  SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
               L   A+D  G  A    +    V I +        +F +P+++  VYE+ P  + + 
Sbjct: 841  TLSLMVSAQDGGGLTAVINAD----VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIG 896

Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDG--G 2587
            T+ A +              G     F +    G + T++PL  +E   + V+      G
Sbjct: 897  TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLD-HETQPVVVLTVQAQLG 955

Query: 2588 EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGA 2647
              P   +T + + V+DVNDN P F+R  +   + I +  P  + +Y   A D+D G NG 
Sbjct: 956  SAPACSSTEVNITVMDVNDNHPAFLRTSDE--IRISQTTPPGTALYLARAEDRDSGRNGL 1013

Query: 2648 VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQP 2707
            +RYS            F ID   G++     L    Q   +L L A D G   P   +  
Sbjct: 1014 IRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLV 1068

Query: 2708 LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF 2767
            L V +E  + +             YQ+      SP   ++      +      + +  Y 
Sbjct: 1069 LTVVIEKREHSPSWTFE----HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL-RYS 1123

Query: 2768 IAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVAD 2826
            +    +   F ++P  G + + R  D E    ++F V A     W P  G    +     
Sbjct: 1124 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA-----WIPEDGFLQNVSTT-- 1176

Query: 2827 LTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
                 V V + D ND  P F        V         + ++ A+D D G N  + Y +L
Sbjct: 1177 -----VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 1231

Query: 2887 AI-HYFRALANDSEDVGQV 2904
            +   +F+   N  E +  V
Sbjct: 1232 SDGKFFKMNPNTGELINWV 1250



 Score =  213 bits (541), Expect = 3e-54
 Identities = 237/821 (28%), Positives = 351/821 (42%), Gaps = 148/821 (18%)

Query: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
            T+SV E   P T++ +I A    L    +    G    +D+D   P  +D F V+ +TG 
Sbjct: 70   TLSVDEGLPPDTLVGDIRA---GLPAAQQQEGSGFFLSEDSDDS-PLLDD-FHVHPDTGI 124

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            +     ++RE    Y    + +  A             ++ + V DVND++P+F    + 
Sbjct: 125  IRTARRLDRERRDHYSFVAATLLGAV-----------VQVEIRVNDVNDHSPRFP---LD 170

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---DLV--PPG-YVQLEDSSAGK 2353
                 + E + PGT      A DPD GL     YTL+   DL   P G + QL   + G 
Sbjct: 171  SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230

Query: 2354 V-----------------IANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDIN 2396
            +                 +  R +D EE       + A D G P R   + V L ++D N
Sbjct: 231  LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290

Query: 2397 DNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYS---------------L 2441
            DN P+F+Q  Y+ AV ED   G  +  V ATD D G    + YS               L
Sbjct: 291  DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350

Query: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501
            GD  + FA+   +G + V   LDRE +  + L   A+D      +     +V+V I VLD
Sbjct: 351  GDA-AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG----GAEPEVATVRVSIAVLD 405

Query: 2502 VNDCRPQ----FSKPQFSTSVYENEPAGTSVITMMATDQD------EGPNGELTYSLEGP 2551
            VND RP     F        V E    G  V  +  +D D      +   GEL   L G 
Sbjct: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL-GD 464

Query: 2552 GVEAFHVDMDSG-------------LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTM 2596
            G  +  ++   G              +  + PL  +S + + L +VATD G PPL     
Sbjct: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524

Query: 2597 LLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLK 2654
            LL+ V D+ND  P+F +        + E     + V  V A+D DE G + A +RY+ ++
Sbjct: 525  LLLRVADLNDQPPLFSQQHYKA--SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582

Query: 2655 TA-----GNRDWEF---------FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
             +     G+   +          F ID  SG I T + LDRE Q    L +VA DLG+P 
Sbjct: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP- 641

Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760
            P      + + ++D++DNEP+F R      Q    T+ EH+P G     VT A DAD G 
Sbjct: 642  PLSATCLVSITVDDVNDNEPIFWR------QVYNATIAEHAPVGHCFLQVT-ASDADSGL 694

Query: 2761 NAIVYYFIAAG----NEEKNFHLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPP 2814
               + Y +  G       + F + P DG + V +D+DRER+ A +  +V+A         
Sbjct: 695  YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG------ 748

Query: 2815 RGPSPTLDLVADLTLQE-VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
                        L+ Q  VRV LED+ND  P F  + Y   ++ + + G+E+I VLA D 
Sbjct: 749  ----------GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798

Query: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
            D G    V Y ++             +V  +FT+ S  GI+
Sbjct: 799  DSGIYGTVAYELI-----------PGNVSSLFTIDSTTGII 828



 Score =  122 bits (306), Expect = 6e-27
 Identities = 127/483 (26%), Positives = 209/483 (43%), Gaps = 51/483 (10%)

Query: 41   LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
            L+ ED P  S +  + A++  N  +P+ + +S  +    F++ P  G +  R+PLD ET+
Sbjct: 884  LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 943

Query: 99   S--EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
                 TV+  +       + +VNI V DVNDN P F      +RI + TP GT +++  A
Sbjct: 944  PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003

Query: 157  TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
             D D G  G + YS   P    FAID A G++ +   L     +   LT+ A DQ    P
Sbjct: 1004 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 1062

Query: 216  LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
             + L  L ++I + ++  P   F +L Y   + E   P      +T + Q +  P G   
Sbjct: 1063 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 1115

Query: 271  ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTP 325
                + Y++     +++F +   +G + L    D E+   Y+      +          P
Sbjct: 1116 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 1165

Query: 326  SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
             D     V+TT  + V D NDN+P F      + + E + V   +   I  +D D   G 
Sbjct: 1166 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 1222

Query: 383  NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHV 441
            N    +Y + ++   F ++P + +      +   + LD E    ++   L  +   P   
Sbjct: 1223 NGQL-LYFLLSDGKFFKMNPNTGE------LINWVALDREHRGHHEMTVLVTDRGSPPRN 1275

Query: 442  GYAKVKITLINENDNRPIFSQPL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSY 497
                V +++ + NDNRP F Q L     ++ + E   V   V TV A D D G   EV+Y
Sbjct: 1276 ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335

Query: 498  FFS 500
              S
Sbjct: 1336 SVS 1338


>gi|16933559 protocadherin LKC precursor [Homo sapiens]
          Length = 1310

 Score =  323 bits (827), Expect = 2e-87
 Identities = 307/1029 (29%), Positives = 474/1029 (46%), Gaps = 94/1029 (9%)

Query: 38   TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
            T +++ ED PVG+    L+A+D DNDPL +G+SG  A  FFAV P TG V L   LD ET
Sbjct: 31   TSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYET 89

Query: 98   KSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
               F V  SVSD    + R++ + V D NDNAP F N  +S  I E  PVG+ +F V A 
Sbjct: 90   LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149

Query: 158  DPDLGAGGSVLYSFQP------PSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATD- 209
            D D+G+ G V+YS +        S+      A G + +   L Y    A YQL + A D 
Sbjct: 150  DKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDL 209

Query: 210  -----QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
                    T   S    L+I + D  D+DP F+   YS ++ E +  GT+V  + A+D D
Sbjct: 210  GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269

Query: 265  KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
            KG    + Y+I        F +    GV+ +NG LDRE  L +   + L V  TE + + 
Sbjct: 270  KGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNI 328

Query: 324  TPSDATVTTTFNILVIDINDNAPEF-NSSEYSVAIT-ELAQVGFA----------LPL-F 370
               +A V+    + V+D+ND+ PEF N S  +   T E AQV F           +P+  
Sbjct: 329  YGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDD 388

Query: 371  IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR--IRVAIPLDYETVDRYD 428
            + +V  D + G N  F + L G ++  F +SP    G A ++  +RV+  +DYE      
Sbjct: 389  LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMA 448

Query: 429  FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL-TVLATDN 487
              + A +SV  +   A V I L + ND+RP F Q LY +++ E+   G+ V  ++ ATD 
Sbjct: 449  VQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDP 508

Query: 488  DAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLI--ARLDYELIQRFTLTIIARDGGGEET 543
            D G +G+++Y     +  D F +D  +G + +     LD E    + LT+ A DGG   +
Sbjct: 509  DTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSS 568

Query: 544  TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
            +  ++I++LD+NDN P     +Y   ++E E +V+  ++    DE    N+++ ++++  
Sbjct: 569  STTLQIHLLDINDNAPVV-SGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLP- 626

Query: 604  SAFGSY-FDISLYEGYGVISVSRPLDYEQIS---NGLIYLTVMAMDAGNPPLNSTVPVTI 659
               G Y  + SL    G++    PLD E I     G I LTV+  D G P L + V VTI
Sbjct: 627  ---GPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTI 683

Query: 660  EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQF 719
             V D NDN P F++ +Y  +V E    G  V  + A D D++    + S   S  G+  F
Sbjct: 684  TVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYF 742

Query: 720  RINA---RSG------EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLD 770
             I      +G       +     LD ET+  + L V A +      +   I  V + + D
Sbjct: 743  MIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGET--IVDVCVNVKD 800

Query: 771  INDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTL-VYSIQPPNKFYSLNS 828
            +NDN PT   A    I + E       V  VVA D D      + + +I        + S
Sbjct: 801  VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGS 860

Query: 829  TT----GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP--LKATSSATVFVNLLD 882
                           +++     +EA  +  +VV   D    P     +++ ++ + + D
Sbjct: 861  LCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIED 920

Query: 883  LNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 940
            +NDN P F  +N  FV  + E +     +  V A D D G NG++ +     + R+DF+ 
Sbjct: 921  VNDNAPYFLPENKTFVI-IPELVLPNREVASVRARDDDSGNNGVILF----SILRVDFIS 975

Query: 941  NSS--------------------SGVVVTTTELDRERIAEYQLRVVASDAGT--PTKSST 978
                                   +G +   T LD      YQ+ V A D  +  P   +T
Sbjct: 976  KDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEAT 1035

Query: 979  STLTIHVLD 987
            +TL +  +D
Sbjct: 1036 TTLNLFTVD 1044



 Score =  229 bits (585), Expect = 3e-59
 Identities = 282/1027 (27%), Positives = 441/1027 (42%), Gaps = 121/1027 (11%)

Query: 1324 ENLALGTEIVRVQAYSIDNLNQITYRF---NAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
            E+L +G +   + A   DN + +TY     NAY        F +   TG + +   +D E
Sbjct: 37   EDLPVGAQAFWLVAEDQDN-DPLTYGMSGPNAY-------FFAVTPKTGEVKLASALDYE 88

Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
                YT  V      P +    ++ + V D NDN+P F  T+ S  SI E  PVG  V +
Sbjct: 89   T--LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFST-SINETLPVGSVVFS 145

Query: 1441 VKAWDPDAGSNGQVVFSL-----ASGNIAGAFEIVTTNDSIGEVFVARPLD-REELDHYI 1494
            V A D D GS G VV+S+     ++G+    F I+      G + +   L    +   Y 
Sbjct: 146  VLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN----GSIVLNGSLSYNNKSAFYQ 201

Query: 1495 LQVVASDRG-------TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
            L++ A D G       T        L ++++D  D  P     F Y+ SV E+   GT+V
Sbjct: 202  LELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREF-YSASVAEDAAKGTSV 260

Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMD-----RISGEIATRPAPPDRERQSFYHL 1602
            + V A D D GIN  + Y I+   +   F +      R++G +  R    + + +    +
Sbjct: 261  LTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSL-DREQLLEADEEVQLQV 319

Query: 1603 VATVEDEGTPTLSATTHVYVTI--VDENDNAPMFQ--------------QPHYEVLLDE- 1645
             AT          A   ++VT+  +D ND+ P F               Q ++   +DE 
Sbjct: 320  TATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEH 379

Query: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEIS-- 1703
                +    +T+   D D+G NGT   ++  G     F +       +A+ ++   +S  
Sbjct: 380  ASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSAL 438

Query: 1704 --HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
              + R T +         +S    S   V +++ DIND+ PTFP+       V E     
Sbjct: 439  VDYERQTAMAVQVVATDSVSQNF-SVAMVTIHLRDINDHRPTFPQSLY-VLTVPEHSATG 496

Query: 1762 RVWTFLAH--DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
             V T   H  D D+G  GQ+ YS++ G+    F + PV G + VR    LDRE+ A Y L
Sbjct: 497  SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556

Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
            T+ A D G   LSS+  + I +LDINDN PV+     NI + E     S       +D  
Sbjct: 557  TLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQEEEGNVSVTIQAHDNDEP 613

Query: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP-----EYKLTISVKDNPEN 1934
               N+RL FN+  G     F ++  TG++    PLDRE I         LT+ V D  E 
Sbjct: 614  GTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE- 672

Query: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ-D 1993
            P +  +    + I + D NDN P+F +S+Y   V E  P      VL G + A DADQ +
Sbjct: 673  PVLGTKVN--VTITVEDINDNLPIFNQSSYNFTVKEEDPG-----VLVGVVKAWDADQTE 725

Query: 1994 IYAVVTYQLLGAQSGLFDINS-------STGVVTVRSGVIIDREAFSPPILELLLLAE-- 2044
                +++ L G+ +  F I         + G + +   V +D E  + P+  L + AE  
Sbjct: 726  ANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYE--TQPVFNLTVSAENP 783

Query: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLT-VHLLENCPPGFSVLQVTATDEDSGLNGE 2103
            D     +   + + + D NDN PT   A+L  + + EN      V  V A+D D+    E
Sbjct: 784  DPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLE 843

Query: 2104 L----VYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESY----------RLTVVATDR 2149
            +    +   +AG     L      V   G+  I++ +   Y          R   +ATD 
Sbjct: 844  IQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDP 903

Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQT-VSVLESAEPGTVIANITAIDHDL--NPK 2206
            G    S    + I I+D+ND+ P FL   +T V + E   P   +A++ A D D   N  
Sbjct: 904  GFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGV 963

Query: 2207 LEYHI--VGIVAKDDTDRLVPNQEDAFAV------NINTGSVMVKSPMNRELVATYEVTL 2258
            + + I  V  ++KD     +P Q   F++      ++  GS+   + ++  L  TY+VT+
Sbjct: 964  ILFSILRVDFISKDGA--TIPFQ-GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020

Query: 2259 SVIDNAS 2265
               D  S
Sbjct: 1021 QARDRPS 1027



 Score =  226 bits (576), Expect = 3e-58
 Identities = 313/1247 (25%), Positives = 518/1247 (41%), Gaps = 172/1247 (13%)

Query: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            ++A D D D    +TY + G  +  F +   TG V + S   +D E       ++ +   
Sbjct: 48   LVAEDQDND---PLTYGMSGPNAYFFAVTPKTGEVKLASA--LDYETLYT--FKVTISVS 100

Query: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGEL 2104
            D   +     +L+ + D NDN P F     +  + E  P G  V  V A D+D G  G +
Sbjct: 101  D-PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMV 159

Query: 2105 VYRIE-----AGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG-------TV 2152
            VY IE      G  +     L  G I +  +     +   Y+L + A D G       T+
Sbjct: 160  VYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI 219

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S    ++I + D  D  P+F+    + SV E A  GT +  + A+D D  +N  + Y 
Sbjct: 220  QCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS 279

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE--LVATYEVTLSVIDNASDL- 2267
            I        +    P   D  A     G + V   ++RE  L A  EV L V    + L 
Sbjct: 280  I--------SYSTRPGWFDIGA----DGVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327

Query: 2268 ---PERSVSVPNAKLTVNVLDVNDNTPQFKPFGI---TYYMER--------ILEGATPGT 2313
                E  VS+    +TV V+DVND+ P+F    +   T+  E         + E A+P  
Sbjct: 328  IYGQEAKVSI---WVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRI 384

Query: 2314 TL--IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK------VIANRTVDYEEV 2365
             +  + +   DPDKG NG    +L       +    + +AG       V  +  VDYE  
Sbjct: 385  PIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQ 444

Query: 2366 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL-TV 2424
              +   V A+D+ S   +  + V + + DIND+ P F Q  Y   V E    G+++  ++
Sbjct: 445  TAMAVQVVATDSVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSI 503

Query: 2425 TATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKDN 2480
             ATD D+G +  I YSL  G+G   F ++P +G + V +   LDRE +  Y LT  A D 
Sbjct: 504  HATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDG 563

Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
             G+++S     S  + I +LD+ND  P  S    S +++  E  G   +T+ A D DE  
Sbjct: 564  -GNLSS-----STTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPG 614

Query: 2541 --NGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQSYE-------KFSLTVVATDGGEPP 2590
              N  L ++L  GP    F +D D+GL+    PL           +  LTV+ +D GEP 
Sbjct: 615  TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV 674

Query: 2591 LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP-LRSNVYEVYATDKDEGLNGAVR 2649
            L     + + V D+NDN P+F +        ++EE P +   V + +  D+ E  N  + 
Sbjct: 675  LGTKVNVTITVEDINDNLPIFNQSSYN--FTVKEEDPGVLVGVVKAWDADQTEA-NNRIS 731

Query: 2650 YSFLKTAGNRDWEFFIIDPI---SGLIQTAQRL------DRESQAVYSLILVASDLGQPV 2700
            +S   +  N    +F+I  +   +G  +   RL      D E+Q V++L  V+++   P 
Sbjct: 732  FSLSGSGAN----YFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT-VSAENPDPQ 786

Query: 2701 PYETMQPLQVALEDIDDNEPLF-------VRPPKGSPQYQLLTVPEHSPRGT-------L 2746
              ET+  + V ++D++DN P         +R  +   Q+  + V   S   T       L
Sbjct: 787  GGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQL 846

Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAG-----NEEKNFHLQP-DGCLLVLRDLDREREAIFS 2800
            V  +      D G     ++ +AA      N+ K    +  D   LV+R  D   +  F 
Sbjct: 847  VNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF- 905

Query: 2801 FIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAK 2860
               +A SN                       + + +ED+ND  P F     T  +  +  
Sbjct: 906  ---QAYSNNG--------------------SLLITIEDVNDNAPYFLPENKTFVIIPELV 942

Query: 2861 VGS-ELIQVLALDADIGNNSLVFYSILAIHYFR--ALANDSEDVGQVFTMGSMD---GIL 2914
            + + E+  V A D D GNN ++ +SIL + +          + V  +FT    D   G +
Sbjct: 943  LPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI 1002

Query: 2915 RTFDLFMAYSPGYFVVDIVARDLAGHND----TAIIGIYILRDDQRVKIVINEIPDRVRG 2970
            +      +   G + V + ARD          T  + ++ +    R ++  +   + V  
Sbjct: 1003 QPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGA 1062

Query: 2971 FEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQM 3030
              +     L+  T   V   ++Q  +D   R     + L  + V       L +D +  M
Sbjct: 1063 NRQAINAALTQATRTTVYIVDIQ-DIDSAARAR-PHSYLDAYFV-FPNGSALTLDELSVM 1119

Query: 3031 IDENKEQLRNLFR-NYNVLDVQPAISVRLPDDMSALQMAIIV-LAILLFLAAMLFVLMNW 3088
            I  +++ L  L +    VL  Q +       D+S   +++I+ L + L L  ++  +   
Sbjct: 1120 IRNDQDSLTQLLQLGLVVLGSQES----QESDLSKQLISVIIGLGVALLLVLVIMTMAFV 1175

Query: 3089 YYRTVHKRKLKAIVAGSAGNRGFIDIMD----MPNTNKYSFDGANPV 3131
              R  + RKL+A+ A     +    +M     +P TN Y+ + ANP+
Sbjct: 1176 CVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPM 1222



 Score =  224 bits (571), Expect = 1e-57
 Identities = 282/1043 (27%), Positives = 437/1043 (41%), Gaps = 138/1043 (13%)

Query: 787  LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENP 845
            L E  P  +    +VA D D   N  L Y +  PN  F+++   TG+++   A+      
Sbjct: 35   LPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVKLASAL------ 85

Query: 846  DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
              +E     K+ +SV+D   P ++      V V   D NDN P FQN  F   + E +P 
Sbjct: 86   -DYETLYTFKVTISVSD---PYIQVQREMLVIVE--DRNDNAPVFQNTAFSTSINETLPV 139

Query: 906  GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD-----FLINSSSGVVVTTTELDRERIAE 960
            G  ++ V+A+D D G  G+V Y +   +P        F I ++  +V+  +     + A 
Sbjct: 140  GSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAF 199

Query: 961  YQLRVVASDAG-------TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR 1013
            YQL + A D G       T   S    L+I V+D  D  P F    Y+ SV+ED  +   
Sbjct: 200  YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259

Query: 1014 VVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAI 1073
            V+ +   D D G+N  + Y I+     G F +G  D V+R    LDRE       +LEA 
Sbjct: 260  VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQ------LLEAD 312

Query: 1074 DNGPVGKRHTGTAT--------------VFVTVLDVNDNRPIFLQSSYEAS--VPEDIP- 1116
            +   V  + T T T              V V V+DVND++P F   S  A    PE+   
Sbjct: 313  EE--VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370

Query: 1117 ------EGHSI-------LQLKATDADEGEFGRVWYRILHGNHGNNFRI-------HVSN 1156
                  + H+        L +   D D+G  G  +   L G     F +         S 
Sbjct: 371  NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASV 429

Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRL 1216
             +L+R    +D ER ++  + V A    +    S   V +++ DIND  P F Q  Y  L
Sbjct: 430  QVLVRVSALVDYERQTAMAVQVVA-TDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYV-L 487

Query: 1217 GLRETAGIGTSVI-VVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLD 1272
             + E +  G+ V   + ATD D+G  G + Y +L G     F++D  +G +   N   LD
Sbjct: 488  TVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLD 547

Query: 1273 YETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI 1332
             E++  Y + + ATD     +     +++  +N+    V   + SY   + E    G   
Sbjct: 548  RESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV---SGSYNIFVQEE--EGNVS 602

Query: 1333 VRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE------KGDF 1384
            V +QA+  D    N     FN      +   F +D  TG++   G +DRE      +G  
Sbjct: 603  VTIQAHDNDEPGTNNSRLLFNLLPGPYSHN-FSLDPDTGLLRNLGPLDREAIDPALEGRI 661

Query: 1385 YTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW 1444
                +V+D G P + + V V ITV D NDN P F+ +S +  ++ E+ P G  V  VKAW
Sbjct: 662  VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYN-FTVKEEDP-GVLVGVVKAW 719

Query: 1445 DPD-AGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFVARPLDREELDHY---ILQVV 1498
            D D   +N ++ FSL SG+ A  F I  +       E ++  P D   LD+    +  + 
Sbjct: 720  DADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPD-VSLDYETQPVFNLT 777

Query: 1499 ASDRGTPPRKKDHILQ--VTILDINDNPPVIE--SPFGYNVSVNENVGGGTAVVQVRATD 1554
             S     P+  + I+   V + D+NDNPP ++  S  G  V+ N +  G  AVV     D
Sbjct: 778  VSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837

Query: 1555 RDIGIN-SVLSYYITEGNKDMA------FRMDRISGEIATRPAPPDRERQSFYHLVA--- 1604
                +   +++   T+   D+       F +         +    D E      LV    
Sbjct: 838  TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRAC 897

Query: 1605 -TVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD 1663
                D G    S    + +TI D NDNAP F   +   ++       N  + +++A D D
Sbjct: 898  DLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDD 957

Query: 1664 EGPNGTVTYAIV----------------AGNIVNTFRIDRHMGVITAAKELDYEISHGRY 1707
             G NG + ++I+                  +I  +   D   G I     LD  +  G Y
Sbjct: 958  SGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTL-QGTY 1016

Query: 1708 TLIVTATDQCPILSHRLTSTTTV 1730
             + V A D+ P L   L +TTT+
Sbjct: 1017 QVTVQARDR-PSLGPFLEATTTL 1038



 Score =  211 bits (538), Expect = 7e-54
 Identities = 273/1075 (25%), Positives = 439/1075 (40%), Gaps = 140/1075 (13%)

Query: 669  PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSG 726
            P F      V + E++  GA   +L A D D       + + Y + G     F +  ++G
Sbjct: 24   PKFLANMTSVILPEDLPVGAQAFWLVAEDQDN------DPLTYGMSGPNAYFFAVTPKTG 77

Query: 727  EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
            E+   S LD ET   + + +   D  +   ++     + + + D NDN P +++  +  +
Sbjct: 78   EVKLASALDYETLYTFKVTISVSDPYIQVQRE-----MLVIVEDRNDNAPVFQNTAFSTS 132

Query: 787  LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPD 846
            + E  P  S V +V+AVD D+G  G +VYSI+        +    +I    +++   +  
Sbjct: 133  INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLS 192

Query: 847  PHEAELMRKIVVSVTDCG---RPPLKATSSATVF--VNLLDLNDNDPTFQNLPFVAEVLE 901
             +      ++ +   D G           S  VF  ++++D  D DP F    + A V E
Sbjct: 193  YNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252

Query: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI--- 958
                G S+  V A+D D+G+N  V Y +     R  +    + GV+     LDRE++   
Sbjct: 253  DAAKGTSVLTVEAVDGDKGINDPVIYSISYS-TRPGWFDIGADGVIRVNGSLDREQLLEA 311

Query: 959  -AEYQLRVVASDA-----GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREF 1012
              E QL+V A++      G   K S   +T+ V+DVND  P F+    ++      P E 
Sbjct: 312  DEEVQLQVTATETHLNIYGQEAKVSI-WVTVRVMDVNDHKPEFYNC--SLPACTFTPEEA 368

Query: 1013 RVVWLNCTDN------------------DVGLNAELSYFITGGNVDGKFSVGYRDA---- 1050
            +V +    D                   D G N      + G + +  FSV    A    
Sbjct: 369  QVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA-FSVSPERAAGSA 427

Query: 1051 ----VVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
                +VR    +D E   A  + + A D+     ++   A V + + D+ND+RP F QS 
Sbjct: 428  SVQVLVRVSALVDYERQTAMAVQVVATDS---VSQNFSVAMVTIHLRDINDHRPTFPQSL 484

Query: 1107 YEASVPEDIPEGHSIL-QLKATDADEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGPR 1164
            Y  +VPE    G  +   + ATD D G +G++ Y +L GN  + F++  VS  + +R   
Sbjct: 485  YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544

Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
             LDRE  + + L ++A   D G + SS  + +++ DIND APV     Y+     E   +
Sbjct: 545  LLDRESQAVYYLTLQA--TDGGNLSSSTTLQIHLLDINDNAPV-VSGSYNIFVQEEEGNV 601

Query: 1225 GTSVIVVQATDRDSGDGGLVNYRILSGA-----EGKFEIDESTGLIITVNYLDYET---- 1275
                + +QA D D  + G  N R+L           F +D  TGL+  +  LD E     
Sbjct: 602  S---VTIQAHDND--EPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPA 656

Query: 1276 -KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
             +   ++ V  +D   P      +V IT+ +  D    F+ +SY   + E    G  +  
Sbjct: 657  LEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGV 715

Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKI-DAITGVITVQGL--------VDREKGDFY 1385
            V+A+  D   +   R +   S      F I   + G    +G         +D E    +
Sbjct: 716  VKAWDADQ-TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774

Query: 1386 TLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW 1444
             LTV A++  P+   T V V + V D NDN P  D  S   + + E+     +VA V A 
Sbjct: 775  NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834

Query: 1445 DPDAGSNGQVVF--------SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQ 1496
            D D  +  ++           +  G++   +  V  N S+  +  ++ +D E  D   L 
Sbjct: 835  DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSV-YINQSKAIDYEACDLVTLV 893

Query: 1497 VVASDRGTPP----RKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
            V A D  T P       +  L +TI D+NDN P         V + E V     V  VRA
Sbjct: 894  VRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRA 953

Query: 1553 TDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRP----------------------- 1589
             D D G N V+ + I         R+D IS + AT P                       
Sbjct: 954  RDDDSGNNGVILFSI--------LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPV 1005

Query: 1590 APPDRERQSFYHLVATVEDEGT--PTLSATTHVYVTIVDENDNAPM-FQQPHYEV 1641
               D   Q  Y +     D  +  P L ATT + +  VD++  + + F  P  EV
Sbjct: 1006 TSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEV 1060



 Score =  211 bits (536), Expect = 1e-53
 Identities = 271/1001 (27%), Positives = 441/1001 (44%), Gaps = 137/1001 (13%)

Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT--TG 1906
            P  L    ++ + E+ PV +    ++A D D   N  LT+ ++  N   A+F   T  TG
Sbjct: 24   PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPN---AYFFAVTPKTG 77

Query: 1907 IVTVNRPLDRERIPEYKLTISVKDNPENPRI-ARRDYDLLLIFLSDENDNHPLFTKSTYQ 1965
             V +   LD E +  +K+TISV D    P I  +R+   +L+ + D NDN P+F  + + 
Sbjct: 78   EVKLASALDYETLYTFKVTISVSD----PYIQVQRE---MLVIVEDRNDNAPVFQNTAFS 130

Query: 1966 AEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL------LGAQSGLFDINSSTGVV 2019
              + E  P G+ +      +LA+D D     +V Y +       G    LF I ++  +V
Sbjct: 131  TSINETLPVGSVVF----SVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIV 186

Query: 2020 TVRSGVIIDREAFSPPILELLLLAEDIG-LLNST--------AHLLITILDDNDNRPTFS 2070
               S    ++ AF     +L L A D+G + ++T          L I+++D  D  P F 
Sbjct: 187  LNGSLSYNNKSAF----YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNA 2130
                +  + E+   G SVL V A D D G+N  ++Y I    +  +      GVIRV N 
Sbjct: 243  REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV-NG 301

Query: 2131 TIDREE----QESYRLTVVATDRGTVPLSGTAIV----TILIDDINDSRPEFLN---PIQ 2179
            ++DRE+     E  +L V AT+         A V    T+ + D+ND +PEF N   P  
Sbjct: 302  SLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPAC 361

Query: 2180 TVSVLESAEPGTVIANITA-IDHDLNPKLEYHIVGIVAKDD------TDRLVPNQEDAFA 2232
            T +      P     N T  +D   +P++    + +V  D       T  L     DA A
Sbjct: 362  TFT------PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA 415

Query: 2233 VNIN----TGSVMVKSPMNRELVATYE--VTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
             +++     GS  V+  +    +  YE    ++V   A+D   ++ SV  A +T+++ D+
Sbjct: 416  FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV--AMVTIHLRDI 473

Query: 2287 NDNTPQFKPFGITYYMERILEGATPGTTLI-AVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
            ND+ P F     + Y+  + E +  G+ +  ++ A DPD G  G +TY+LL        Q
Sbjct: 474  NDHRPTFPQ---SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530

Query: 2346 LEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
            ++  S    + N   +D E       T++A+D G+   +  + ++L  +DINDN P+   
Sbjct: 531  VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL--LDINDNAPVVSG 588

Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEYSL--GDGESKFAINPTTGDIYVL 2460
             SY   +F     G + +T+ A D D    N + + ++L  G     F+++P TG +  L
Sbjct: 589  -SYN--IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645

Query: 2461 SSLDREKKD-----HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
              LDRE  D       +LT L  D    V   +    V V I V D+ND  P F++  ++
Sbjct: 646  GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK----VNVTITVEDINDNLPIFNQSSYN 701

Query: 2516 TSVYENEPAGTSVITMMATDQDEGP-NGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSY 2574
             +V E +P G  V  + A D D+   N  +++SL G G   F   M  GLV      + Y
Sbjct: 702  FTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYF---MIRGLVLGAGWAEGY 757

Query: 2575 EK--------------FSLTVVATDGGEPPLWGTTML--LVEVIDVNDNRPVF-VRPPNG 2617
             +              F+LTV A +    P  G T++   V V DVNDN P   V    G
Sbjct: 758  LRLPPDVSLDYETQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG 815

Query: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRY-SFLKTAGNRD-----WEFFIIDPISG 2671
              + + E       V  V A+D D      ++  + L T    D     W +F +     
Sbjct: 816  --IRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGS 873

Query: 2672 L-IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQ---PLQVALEDIDDNEPLFVRPPK 2727
            + I  ++ +D E+  + +L++ A DL     ++       L + +ED++DN P F+   K
Sbjct: 874  VYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933

Query: 2728 GSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
                   + +PE       V +V  A D D G N ++ + I
Sbjct: 934  -----TFVIIPELVLPNREVASVR-ARDDDSGNNGVILFSI 968



 Score =  203 bits (516), Expect = 3e-51
 Identities = 276/1029 (26%), Positives = 422/1029 (41%), Gaps = 139/1029 (13%)

Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
            G + +  +A D+D+ P   + Y  M G     F ++P  G +++     LD ET+  + +
Sbjct: 42   GAQAFWLVAEDQDNDP---LTYG-MSGPNAYFFAVTPKTGEVKLAS--ALDYETLYTFKV 95

Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
            TI   D   P +     + + V D NDN PV  N   + +I+E  PV S V  VLA D D
Sbjct: 96   TISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKD 152

Query: 1880 SGCNARLTFNI-----TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
             G    + ++I     + G+ E  F I A   IV         +   Y+L +   D    
Sbjct: 153  MGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGM 212

Query: 1935 PRIARRDYDLLLIFLS----DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
                      L +FLS    D+ D  P F +  Y A V E++  GT +  +     A+D 
Sbjct: 213  YHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVE----AVDG 268

Query: 1991 DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL- 2048
            D+ I   V Y +    + G FDI +  GV+ V   +  ++   +   ++L + A +  L 
Sbjct: 269  DKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327

Query: 2049 -----LNSTAHLLITILDDNDNRP----------TFSP----ATLTVHLLENCPPGFSV- 2088
                    +  + + ++D ND++P          TF+P       T ++ E+  P   + 
Sbjct: 328  IYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPID 387

Query: 2089 -LQVTATDEDSGLNGELVYRIEAGAQDRFLIH--------LVTGVIRVGNATIDREEQES 2139
             L +   D D G NG  +  +     + F +          V  ++RV +A +D E Q +
Sbjct: 388  DLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV-SALVDYERQTA 446

Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN-ITA 2198
              + VVATD  +   S  A+VTI + DIND RP F   +  ++V E +  G+V+ + I A
Sbjct: 447  MAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHA 505

Query: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP--MNRELVATYEV 2256
             D D          G   +     L  N  D F V+  +G+V V++   ++RE  A Y +
Sbjct: 506  TDPD---------TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556

Query: 2257 TLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            TL   D  +          +  L +++LD+NDN P        +  E        G   +
Sbjct: 557  TLQATDGGN-------LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEE------EGNVSV 603

Query: 2317 AVAAVDPDK-GLNGLVTYTLLDLVPPGYVQ--LEDSSAGKVIANRTVDYEEVH-----WL 2368
             + A D D+ G N   +  L +L+P  Y      D   G +     +D E +       +
Sbjct: 604  TIQAHDNDEPGTNN--SRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661

Query: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
              TV  SD G P    ++ V + + DINDN PIF+Q SY   V E+ P G ++  V A D
Sbjct: 662  VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWD 720

Query: 2429 ADSGNF-ALIEYSL-GDGESKFAINPTT-----GDIYVL----SSLDREKKDHYILTALA 2477
            AD       I +SL G G + F I          + Y+      SLD E +  + LT  A
Sbjct: 721  ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780

Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF-STSVYENEPAGTSVITMMATDQ 2536
             +NP        E  V V + V DVND  P           V EN      V  ++A+D 
Sbjct: 781  -ENPDPQGG---ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836

Query: 2537 DEGPNGEL---TYSLEGPGVEA-------FHVDMDSGLVTTQRPLQSYEKFSLTV----- 2581
            D     E+          GV+        F V  +  +   Q     YE   L       
Sbjct: 837  DTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRA 896

Query: 2582 --VATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
              +ATD G         LL+ + DVNDN P F+ P N T + I E +     V  V A D
Sbjct: 897  CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL-PENKTFVIIPELVLPNREVASVRARD 955

Query: 2640 KDEGLNGAVRYSFLKTAG-NRD---------WEFFI---IDPISGLIQTAQRLDRESQAV 2686
             D G NG + +S L+    ++D         +  F     D  +G IQ    LD   Q  
Sbjct: 956  DDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGT 1015

Query: 2687 YSLILVASD 2695
            Y + + A D
Sbjct: 1016 YQVTVQARD 1024



 Score =  197 bits (500), Expect = 2e-49
 Identities = 227/777 (29%), Positives = 340/777 (43%), Gaps = 121/777 (15%)

Query: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD-DTDRLVPNQEDA-- 2230
            FL P   VSV  +  P   +AN+T++    +  +      +VA+D D D L         
Sbjct: 9    FLLPALVVSVAANVAP-KFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA 67

Query: 2231 --FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
              FAV   TG V + S ++ E + T++VT+SV D    +          ++ V V D ND
Sbjct: 68   YFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQR--------EMLVIVEDRND 119

Query: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLED 2348
            N P F+    T +   I E    G+ + +V AVD D G  G+V Y++  ++P       D
Sbjct: 120  NAPVFQN---TAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIP----STGD 172

Query: 2349 S-------SAGKVIANRTVDYEEVH-WLNFTVRASDNGSPPR-----AAEIPVYLEI--V 2393
            S       + G ++ N ++ Y     +    ++A D G            +PV+L I  V
Sbjct: 173  SEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232

Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAIN 2451
            D  D +P F +  Y  +V ED   GT +LTV A D D G    + YS+        F I 
Sbjct: 233  DQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG 292

Query: 2452 PTTGDIYVLSSLDREK----KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
               G I V  SLDRE+     +   L   A +   ++     + S+ V ++V+DVND +P
Sbjct: 293  -ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKP 351

Query: 2508 QF------------SKPQFSTSVYENEPAGTSV----ITMMATDQDEGPNGELTYSLEGP 2551
            +F             + Q + + Y +E A   +    +TM+  D D+G NG    SL GP
Sbjct: 352  EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP 411

Query: 2552 GVEAFHVDMD--SGLVTTQ-----RPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEV 2601
              EAF V  +  +G  + Q       L  YE+    ++ VVATD      +   M+ + +
Sbjct: 412  DAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQN-FSVAMVTIHL 470

Query: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE-VYATDKDEGLNGAVRYSFLKTAGNRD 2660
             D+ND+RP F  P +  +L + E     S V + ++ATD D G  G + YS L   G   
Sbjct: 471  RDINDHRPTF--PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA-- 526

Query: 2661 WEFFIIDPISGLI--QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDN 2718
             + F +DP+SG +  +  + LDRESQAVY L L A+D G      +   LQ+ L DI+DN
Sbjct: 527  -DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDN 582

Query: 2719 EPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP-----NAIVYYFIAAGNE 2773
             P+       S  Y +    E        GNV+  + A +       N+ + + +  G  
Sbjct: 583  APVV------SGSYNIFVQEEE-------GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPY 629

Query: 2774 EKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL----- 2827
              NF L PD G L  L  LDRE  AI   +             G      LV+D      
Sbjct: 630  SHNFSLDPDTGLLRNLGPLDRE--AIDPAL------------EGRIVLTVLVSDCGEPVL 675

Query: 2828 -TLQEVRVVLEDINDQPPRFTKAEYTAGV-ATDAKVGSELIQVLALDADIGNNSLVF 2882
             T   V + +EDIND  P F ++ Y   V   D  V   +++    D    NN + F
Sbjct: 676  GTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISF 732



 Score =  196 bits (498), Expect = 3e-49
 Identities = 228/877 (25%), Positives = 387/877 (44%), Gaps = 132/877 (15%)

Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
            P F     +V L E+ P G     + A D+D   N  L Y +       F +   TG ++
Sbjct: 24   PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80

Query: 2127 VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLES 2186
            + +A +D E   ++++T+  +D     +     + ++++D ND+ P F N   + S+ E+
Sbjct: 81   LASA-LDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQNTAFSTSINET 136

Query: 2187 AEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAVNINTGSVMVK 2243
               G+V+ ++ A+D D+         G+V     ++++P+  D+   F +  N   V+  
Sbjct: 137  LPVGSVVFSVLAVDKDMGS------AGMVVYS-IEKVIPSTGDSEHLFRILANGSIVLNG 189

Query: 2244 SPMNRELVATYEVTLSVIDNASDLPER---SVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
            S       A Y++ L   D             S+P   L+++V+D  D  PQF      +
Sbjct: 190  SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLP-VFLSISVVDQPDLDPQFVR---EF 245

Query: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360
            Y   + E A  GT+++ V AVD DKG+N  V Y++     PG+  +   + G +  N ++
Sbjct: 246  YSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI--GADGVIRVNGSL 303

Query: 2361 DYEEVH------WLNFTVRASDNGSPPRAAEIPVYL--EIVDINDNNPIFDQPSYQEAVF 2412
            D E++        L  T   +      + A++ +++   ++D+ND+ P F   S     F
Sbjct: 304  DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTF 363

Query: 2413 ED------------------VPVGTIILTVTATDADSGNFALIEYSLGDGESK-FAINPT 2453
                                +P+    LT+   D D G+      SLG  +++ F+++P 
Sbjct: 364  TPEEAQVNFTGYVDEHASPRIPIDD--LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421

Query: 2454 TGD--------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
                       + V + +D E++    +  +A D+      ++  +   V I + D+ND 
Sbjct: 422  RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV-----SQNFSVAMVTIHLRDINDH 476

Query: 2506 RPQFSKPQFSTSVYENEPAGTSVI-TMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSG 2563
            RP F +  +  +V E+   G+ V  ++ ATD D G  G++TYSL  G G + F VD  SG
Sbjct: 477  RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536

Query: 2564 LVTTQR----PLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
             VT +       +S   + LT+ ATDGG   L  +T L + ++D+NDN PV     N   
Sbjct: 537  TVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYN--- 591

Query: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
            + ++EE    S   + +  D+    N  + ++ L    + +   F +DP +GL++    L
Sbjct: 592  IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHN---FSLDPDTGLLRNLGPL 648

Query: 2680 DRES-----QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
            DRE+     +    L ++ SD G+PV   T   + + +EDI+DN P+F         Y  
Sbjct: 649  DREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIF-----NQSSYNF 702

Query: 2735 LTVPEHSPRGTLVGNVTGAVDAD--EGPNAIVY--------YF------IAAGNEEKNFH 2778
             TV E  P G LVG V  A DAD  E  N I +        YF      + AG  E    
Sbjct: 703  -TVKEEDP-GVLVG-VVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759

Query: 2779 LQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 2838
            L PD        LD E + +F+  V A +      P+G           T+ +V V ++D
Sbjct: 760  LPPDV------SLDYETQPVFNLTVSAEN----PDPQGGE---------TIVDVCVNVKD 800

Query: 2839 INDQPPRFTKAEYTA-GVATDAKVGSELIQVLALDAD 2874
            +ND PP    A      VA +     ++  V+A D D
Sbjct: 801  VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837



 Score =  185 bits (469), Expect = 7e-46
 Identities = 266/1058 (25%), Positives = 439/1058 (41%), Gaps = 128/1058 (12%)

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIV 187
            AP F     SV +PE+ PVG   F + A D D      + Y    P + FFA+    G V
Sbjct: 23   APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
             +   LDYET   +++T++ +D      +     + +I+ D  D  P+F N  +ST+I E
Sbjct: 80   KLASALDYETLYTFKVTISVSDP----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135

Query: 248  HSPPGTTVRIITAIDQDKGRPRGIGYTI-----VSGNTNSIFALDYISGVLTLNGLLDRE 302
              P G+ V  + A+D+D G    + Y+I      +G++  +F +   +G + LNG L   
Sbjct: 136  TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYN 194

Query: 303  NPLYSHGFILTVKGTELN---DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
            N   S  + L +K  +L     +      ++    +I V+D  D  P+F    YS ++ E
Sbjct: 195  NK--SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252

Query: 360  LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
             A  G ++ L ++ VD D+  G+N    +Y +  ++      P      AD  IRV   L
Sbjct: 253  DAAKGTSV-LTVEAVDGDK--GINDPV-IYSISYSTR-----PGWFDIGADGVIRVNGSL 303

Query: 420  DYETV----DRYDFDLFANESVPDHVGY-AKVKI----TLINENDNRPIFSQPLYNISL- 469
            D E +    +     + A E+  +  G  AKV I     +++ ND++P F    YN SL 
Sbjct: 304  DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLP 359

Query: 470  -------------------YENVTVGTSVLTVLATDNDAGTFGE-VSYFFSDDPDRFSLD 509
                               + +  +    LT++  D D G+ G  +      D + FS+ 
Sbjct: 360  ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419

Query: 510  KDTG--------LIMLIARLDYELIQRFTLTIIARDGGGEE-TTGRVRINVLDVNDNVPT 560
             +          L+ + A +DYE      + ++A D   +  +   V I++ D+ND+ PT
Sbjct: 420  PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT 479

Query: 561  FQKDAYVGALRENEPSVTQLV-RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
            F +  YV  + E+  + + +   + ATD D+    QITYS++  +     F +    G  
Sbjct: 480  FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTV 538

Query: 620  VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679
             +     LD E  S  + YLT+ A D GN  L+S+  + I + D NDN P  S  +Y + 
Sbjct: 539  TVRNGELLDRE--SQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVS-GSYNIF 593

Query: 680  VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG--STQFRINARSGEITTTSLLDRE 737
            V E    G   + + A D D         +   L G  S  F ++  +G +     LDRE
Sbjct: 594  VQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDRE 651

Query: 738  T---KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
                  E  +++  +    G         V IT+ DINDN P +  + Y   + E   P 
Sbjct: 652  AIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE-EDPG 710

Query: 795  SDVTTVVAVDPDLGE-NGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPD---PHE 849
              V  V A D D  E N  + +S+      ++ +             L R  PD    +E
Sbjct: 711  VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL-RLPPDVSLDYE 769

Query: 850  AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEGIPAGV 907
             + +  + VS  +    P    +   V VN+ D+NDN PT    +L  +     G   G 
Sbjct: 770  TQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHG- 826

Query: 908  SIYQVVAIDLDEG------LNGLVSYRMPVGMPRMD---FLINSSSGVVVTTTE-LDRER 957
             +  VVA D+D        L  ++  +  V +  +    F + ++  V +  ++ +D E 
Sbjct: 827  QVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEA 886

Query: 958  IAEYQLRV----VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYN-VSVSEDVPREF 1012
                 L V    +A+D G    S+  +L I + DVND  P F P     V + E V    
Sbjct: 887  CDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNR 946

Query: 1013 RVVWLNCTDNDVGLNAELSYFI--------TGGNV--DGKFSVGYRDAV------VRTVV 1056
             V  +   D+D G N  + + I         G  +   G FS+            ++ V 
Sbjct: 947  EVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVT 1006

Query: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
             LD      Y + ++A D   +G     T T+ +  +D
Sbjct: 1007 SLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044



 Score = 92.8 bits (229), Expect = 5e-18
 Identities = 127/518 (24%), Positives = 209/518 (40%), Gaps = 77/518 (14%)

Query: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
            ED+PVG     + A D D  N  L     G     FA+ P TG++ + S+LD E    + 
Sbjct: 37   EDLPVGAQAFWLVAEDQD--NDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFK 94

Query: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532
            +T    D    V         ++++ V D ND  P F    FSTS+ E  P G+ V +++
Sbjct: 95   VTISVSDPYIQVQR-------EMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL 147

Query: 2533 ATDQDEGPNGELTYSLE------GPGVEAFHVDMDSGLVTTQRPLQSYEK---FSLTVVA 2583
            A D+D G  G + YS+E      G     F + + +G +     L    K   + L + A
Sbjct: 148  AVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKA 206

Query: 2584 TDGGEPPLWGTT---------MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
             D G   ++  T          L + V+D  D  P FVR        + E+    ++V  
Sbjct: 207  CDLG--GMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA--SVAEDAAKGTSVLT 262

Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFI----IDPISGLIQTAQRLDRESQAVYSLI 2690
            V A D D+G+N  V YS   +   R   F I    +  ++G +   Q L+ + +    + 
Sbjct: 263  VEAVDGDKGINDPVIYSI--SYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVT 320

Query: 2691 LVASDL---GQPVPYETMQPLQVALEDIDDNEPLFVR--------PPKGSPQYQLLTVPE 2739
               + L   GQ         + V + D++D++P F           P+ +       V E
Sbjct: 321  ATETHLNIYGQEAKVSIW--VTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378

Query: 2740 HSPRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGC---------LLVLR 2789
            H+     + ++T  V D D+G N   +     G + + F + P+           + V  
Sbjct: 379  HASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSA 437

Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
             +D ER+   +  V A+ + S               + ++  V + L DIND  P F ++
Sbjct: 438  LVDYERQTAMAVQVVATDSVS--------------QNFSVAMVTIHLRDINDHRPTFPQS 483

Query: 2850 EYTAGVATDAKVGSELI-QVLALDADIGNNSLVFYSIL 2886
             Y   V   +  GS +   + A D D G    + YS+L
Sbjct: 484  LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLL 521


>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
          Length = 1790

 Score =  305 bits (782), Expect = 4e-82
 Identities = 338/1179 (28%), Positives = 534/1179 (45%), Gaps = 139/1179 (11%)

Query: 224  IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR------PRG-----IG 272
            I++ D  D  P F +  Y   + E +P GTT  I T    D G       P G     I 
Sbjct: 140  IVVRDRNDNSPTFKHESYYATVNELTPVGTT--IFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 273  YTIVSGNTNSIFALDY-ISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDRTPSDATV 330
            Y      +N  F +   ++G + L   L+ E+       I    +   LN+ RT      
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT-----T 252

Query: 331  TTTFNILVIDINDNAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVV 374
            TTT  + V+D +D  P F       N+ +     Y  AI EL       P+     IQ +
Sbjct: 253  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312

Query: 375  DKDENLGLNS----MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            D+D N+   S    +    LVG    +   F + P + +      + +  P++ +   ++
Sbjct: 313  DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKF 366

Query: 428  DFDLFANESVPDHV-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------T 477
            D  + A +     +  +A + I +++EN+  P F+ P Y   + E+  VG         T
Sbjct: 367  DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 426

Query: 478  SVLTVLATDNDAGTFG---------EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELI 526
            S L ++A D D              E+  F +D    F++ +   T  + L+  +D E  
Sbjct: 427  SPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 486

Query: 527  QRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRAT 586
            Q +T +I A DG  E     V I V+D NDN PTF + +Y   +  +      +++L A 
Sbjct: 487  QTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 546

Query: 587  DEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDA 646
            D D   N +ITY I+     G+  D  + +  G+I+++  +  E I      LTV A D 
Sbjct: 547  DADEGSNGEITYEIL----VGAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADN 600

Query: 647  GNPP--LNSTVPVTIEVFDEND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE 703
              P    NS   V IEV   N+ +PP F +  Y + + E +  GA +L L ATD +    
Sbjct: 601  APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--- 657

Query: 704  YGQESIIYSLE-GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
               +SI Y++E G  Q  F ++  +G +T    LDRE+   YILI+ A DG       T 
Sbjct: 658  ---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTS 711

Query: 761  IATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP 819
             ATVNI + D+NDN P +    P  +++VE    ++ V  V A DPD G NG + YS+  
Sbjct: 712  TATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGN 770

Query: 820  PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVN 879
             N  + + S  G I T    L+RE  D +E      +VV  TD    P  +T   T+ + 
Sbjct: 771  FNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDGAVHPRHST--LTLAIK 820

Query: 880  LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
            +LD++DN P F N  +   V E +PAG +I Q+ A D+D G N  VSYR+     +  F 
Sbjct: 821  VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 878

Query: 940  INSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
            ++  +G +     LD E   + +  +     A D         +T+T+ V D+ND  P F
Sbjct: 879  LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 938

Query: 996  FPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDA 1050
               +Y   V+ D  +   +  +   D D  GL A  + Y +           F V     
Sbjct: 939  SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998

Query: 1051 VVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
             V T V L+ E T  + L++ A D+G PV    + +ATV + VL   +  P F Q  Y  
Sbjct: 999  RVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRP 1054

Query: 1110 S-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR 1168
              V E   +G  +  + A   ++     + Y I+ GN  + F I+   G++     PLD 
Sbjct: 1055 PPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDY 1109

Query: 1169 ERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRET 1221
            E  +S+VL V+A + ++       P +S+  +V + ++D N+  PVF ++ Y   G+ E 
Sbjct: 1110 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSED 1168

Query: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETK 1276
            A + TSV+ V+ATD+D+G+  ++ YR++      G EG F ++  TGLI T        +
Sbjct: 1169 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRR 1227

Query: 1277 TSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
            + +   V ATD       G   V ++++N+LD  V  SN
Sbjct: 1228 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266



 Score =  295 bits (754), Expect = 7e-79
 Identities = 317/1180 (26%), Positives = 516/1180 (43%), Gaps = 122/1180 (10%)

Query: 833  IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
            + +T  +LDR+ P       +  IVV V  C    +       V + + D NDN PTF++
Sbjct: 101  LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 154

Query: 893  LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRM------PVGMPRMDFLIN 941
              + A V E  P G +I+        A D+D+G NG + Y +      P      +  + 
Sbjct: 155  ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL- 213

Query: 942  SSSGVVVTTTELDRERIAEYQLRVVASDAG---TPTKSSTSTLTIHVLDVNDETPTFFPA 998
              +G +V    L+ E    Y + + A+D        +++T+TLT+ VLD +D  P F P 
Sbjct: 214  MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPC 273

Query: 999  V------------YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITG 1036
            V            Y  ++ E   P E   +     +   D D  +        + Y I  
Sbjct: 274  VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILV 333

Query: 1037 GNVDGK---FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1093
            G  +     F +  R A +  +  ++R+    + L+++A  +   G      A + + +L
Sbjct: 334  GTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEIL 391

Query: 1094 DVNDNRPIFLQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWY----- 1139
            D N+  P F   SY+  + E  P G +I         L++ A D D  +           
Sbjct: 392  DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDP 451

Query: 1140 --RILHGNHGNNFRIHVSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRV 1194
               +   ++ + F +    G+   +   +P+DRE   ++   + A++   G   S  V V
Sbjct: 452  ELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIV 507

Query: 1195 IVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEG 1254
             + V D ND  P F +  Y      +    G SVI + A D D G  G + Y IL GA+G
Sbjct: 508  NIQVMDANDNTPTFPEISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQG 566

Query: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV- 1311
             F I+++TGLI     ++     +Y + V A D APP  +    C+VYI +L   +++  
Sbjct: 567  DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626

Query: 1312 QFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVI 1371
            +F    Y   I E + +G  ++ +QA   +  + ITY   A  +   + +F +   TG++
Sbjct: 627  RFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGIL 682

Query: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
            T+   +DRE  D Y L + A DG P   ST  V I V D NDN+P FD      +S+ E+
Sbjct: 683  TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742

Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELD 1491
                  V  VKA DPDAG NGQV +SL  GN    F I     S G ++ A  L+RE  D
Sbjct: 743  -EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRD 795

Query: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
            +Y L VVA+D    PR     L + +LDI+DN PV  +   Y V V EN+  GT ++Q+ 
Sbjct: 796  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIE 854

Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATV 1606
            A D D+G N  +SY I        F +   +GE++        A PD+E  S   LV   
Sbjct: 855  AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAF 911

Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG 1665
            +  GT      T V V + D ND  P+F +  Y+ ++   PD +  T + T+ A D D  
Sbjct: 912  DIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPP 968

Query: 1666 --PNGTVTYAIVAGNI---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
              P   V Y +         + F ++   G +     L+ E +     ++V   D  P++
Sbjct: 969  GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028

Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQV 1779
            S    S+ TV + V    + +P F ++   P  V+E    G  V    A    +  N  +
Sbjct: 1029 S----SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSI 1079

Query: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSST 1834
             YSI+ G+    F I+ + GV+ V   ++ +  T     +   +L +   +  +P  S+T
Sbjct: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1139

Query: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---T 1891
              V I + D N++ PV         +SE++ + + V  V A+D D+G  + + + +    
Sbjct: 1140 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1199

Query: 1892 AGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
                +  F +   TG++         R   +K  +   D+
Sbjct: 1200 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1239



 Score =  288 bits (737), Expect = 6e-77
 Identities = 320/1103 (29%), Positives = 487/1103 (44%), Gaps = 112/1103 (10%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 133  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 193  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 253  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 313  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 372  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427

Query: 368  PLFIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSV----QGKADIRIRVAIPLDYE 422
            PL I  +DKD E++  +    V       H F+   TSV    Q      + +  P+D E
Sbjct: 428  PLRIVALDKDIEDVPPSG---VPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 484

Query: 423  TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
                Y F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ +
Sbjct: 485  EQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543

Query: 483  LATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG-- 539
             A D D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D    
Sbjct: 544  TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 603

Query: 540  --GEETTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQI 596
                 +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + I
Sbjct: 604  AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSI 660

Query: 597  TYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVP 656
            TY+I +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  
Sbjct: 661  TYAIENGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTAT 714

Query: 657  VTIEVFDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 713
            V I V D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL
Sbjct: 715  VNIVVTDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSL 768

Query: 714  EG-STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
               +  FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+
Sbjct: 769  GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDID 825

Query: 773  DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTT 830
            DN P + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  T
Sbjct: 826  DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 883

Query: 831  GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
            G++    + LD E     EA +   +         PP      ATV V + D+ND  P F
Sbjct: 884  GELSLLRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVF 938

Query: 891  QNLPFVAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSG 945
                +   V      G  I  V A D D  GL    V YR   +    P   F +   SG
Sbjct: 939  SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998

Query: 946  VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVS 1005
             V+T   L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y     
Sbjct: 999  RVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPV 1057

Query: 1006 EDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA 1065
             ++  +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +
Sbjct: 1058 SELATKGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1114

Query: 1066 YMLILEA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
            Y+L ++A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     
Sbjct: 1115 YVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFT 1173

Query: 1120 SILQLKATDADEGEFGRVWYRIL 1142
            S+L++KATD D G +  + YR++
Sbjct: 1174 SVLRVKATDKDTGNYSVMAYRLI 1196



 Score =  283 bits (723), Expect = 3e-75
 Identities = 341/1265 (26%), Positives = 535/1265 (42%), Gaps = 150/1265 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 44   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 100  FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 155  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 213  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 269  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 329  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATD---EDSPPNNQIT 597
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D   ED PP+   T
Sbjct: 389  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448

Query: 598  YSIVSASAFGSYFDISLYEGYGV---ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNST 654
                       Y  +      G+   +++ +P+D E+       +T       + P    
Sbjct: 449  KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP---- 504

Query: 655  VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
            V V I+V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y + 
Sbjct: 505  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEIL 561

Query: 715  GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
               Q  F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N
Sbjct: 562  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 621

Query: 773  DNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
            +  P  +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ T
Sbjct: 622  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSET 678

Query: 830  TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
            TG I T    LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P 
Sbjct: 679  TG-ILTLGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPV 728

Query: 890  FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
            F   LP    V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + 
Sbjct: 729  FDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIY 784

Query: 949  TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
            T  +L+RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++
Sbjct: 785  TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844

Query: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TA 1064
            P    ++ +   D D+G N  +SY I    V   F++      +  +  LD E      A
Sbjct: 845  PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902

Query: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +   ++EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  +
Sbjct: 903  SITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960

Query: 1125 KATDADEGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
             A DAD       RV YR   +      + F +   +G ++     L+ E  +   L+V 
Sbjct: 961  YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVV 1019

Query: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
            A++     M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +  
Sbjct: 1020 AFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS 1078

Query: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPP 1291
                + Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P
Sbjct: 1079 ----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1134

Query: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYR 1349
                   VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR
Sbjct: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1194

Query: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITV 1408
                   + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V
Sbjct: 1195 LIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1254

Query: 1409 LDEND 1413
            +++ D
Sbjct: 1255 VNQLD 1259



 Score =  281 bits (718), Expect = 1e-74
 Identities = 346/1343 (25%), Positives = 586/1343 (43%), Gaps = 160/1343 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 138  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 258  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 318  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 375  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434

Query: 2095 DED------SGLNGELVYRIEAGAQDRFLIHLVT--GVIRVGNAT--IDREEQESYRLTV 2144
            D+D      SG+  +    +     D   +  VT  G+ R       +DREEQ++Y  ++
Sbjct: 435  DKDIEDVPPSGVPTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493

Query: 2145 VATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-- 2202
             A D   V  S   IV I + D ND+ P F      V V     PG  +  +TA+D D  
Sbjct: 494  TAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551

Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
             N ++ Y I           LV  Q D F +N  TG + +   +   +  TY +T+   D
Sbjct: 552  SNGEITYEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599

Query: 2263 NASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVD 2322
            NA    ER  S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D
Sbjct: 600  NAPPA-ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATD 654

Query: 2323 PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPR 2382
             +      +TY + +  P     L +++ G +   + +D E        + ASD G P  
Sbjct: 655  RE---GDSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDG 709

Query: 2383 AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442
             +   V + + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG
Sbjct: 710  TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 769

Query: 2443 DGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDV 2502
            +  + F I  + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD+
Sbjct: 770  NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDI 824

Query: 2503 NDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMD 2561
            +D  P F+   ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   
Sbjct: 825  DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPF 882

Query: 2562 SGLVTTQRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
            +G ++  R L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF 
Sbjct: 883  TGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFS 939

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPIS 2670
            +     +  +  +    + +  VYA D D  GL  + VRY             F ++  S
Sbjct: 940  KRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997

Query: 2671 GLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSP 2730
            G + T   L+ E   ++ L++VA D G+PV   +     + L       P F +      
Sbjct: 998  GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE----- 1050

Query: 2731 QYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLR 2789
            +Y+   V E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V  
Sbjct: 1051 EYRPPPVSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1105

Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
             LD E    +   V+A S             L + +     +V + ++D N+ PP F K 
Sbjct: 1106 PLDYETRTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1159

Query: 2850 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGS 2909
             Y  GV+ DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +
Sbjct: 1160 FYIGGVSEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVET 1211

Query: 2910 MDGILRTFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEI 2964
              G+++T  LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  
Sbjct: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVP 1268

Query: 2965 PDRVRGFEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRD 3017
            P  V    E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  
Sbjct: 1269 PTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ 1328

Query: 3018 TNRILDVDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMA 3068
            TNR +D + + + +D     +   F+ Y      +L+++   +V    +  + +   + A
Sbjct: 1329 TNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGA 1388

Query: 3069 IIVLAILLFLA---AMLFVLMNW 3088
            ++ LA ++ L    A+L VL+++
Sbjct: 1389 LLALAFIIILCCIPAILVVLVSY 1411



 Score =  273 bits (699), Expect = 2e-72
 Identities = 320/1184 (27%), Positives = 520/1184 (43%), Gaps = 149/1184 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 137  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 196  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 251  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 311  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 370  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429

Query: 1656 TIQALDLD---EGPNGTVT----YAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHG 1705
             I ALD D     P+G  T      +   +  + F + +  G+   +T  + +D E    
Sbjct: 430  RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQ 487

Query: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
             YT  +TA D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V
Sbjct: 488  TYTFSITAFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540

Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
                A D D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A
Sbjct: 541  IQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQA 597

Query: 1824 RDRGMPP--LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADS 1880
             D   P    +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D + 
Sbjct: 598  ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG 657

Query: 1881 GCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIAR 1939
                 +T+ I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A 
Sbjct: 658  DS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 714

Query: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
             +     I ++D NDN P+F     +   +    A   +    G + A D D  I   V 
Sbjct: 715  VN-----IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVH 765

Query: 2000 YQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLI 2057
            Y L G  + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I
Sbjct: 766  YSL-GNFNNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAI 819

Query: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL 2117
             +LD +DN P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F 
Sbjct: 820  KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFF 877

Query: 2118 -IHLVTG---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRP 2172
             +H  TG   ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P
Sbjct: 878  ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPP 936

Query: 2173 EFLNPIQTVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQE 2228
             F   I    V   A  GT I  + A D D       ++ Y +      DD     P   
Sbjct: 937  VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPA 988

Query: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
              F V  ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++ 
Sbjct: 989  SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHP 1041

Query: 2289 NT-PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
               P+F      Y    + E AT GT +  ++A      +N  + Y+++         + 
Sbjct: 1042 GEIPRFTQE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095

Query: 2348 DSSAGKVIANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
            + + G +  N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P
Sbjct: 1096 NIT-GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1154

Query: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTG 2455
            +F +  Y   V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG
Sbjct: 1155 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1214

Query: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
             I         ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1215 LIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1258



 Score =  267 bits (683), Expect = 1e-70
 Identities = 332/1252 (26%), Positives = 532/1252 (42%), Gaps = 159/1252 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 106  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 163  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 223  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 283  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 343  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402

Query: 1421 TSDSAVSIPEDCPVGQRVAT----------------VKAWDPDAGSNGQVVFSLASGNIA 1464
             S     I E  PVG  ++                 ++   P           L   +  
Sbjct: 403  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461

Query: 1465 GAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNP 1524
              F +  T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN 
Sbjct: 462  SVFTVTQTGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNT 518

Query: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
            P       Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G 
Sbjct: 519  PTFPE-ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGL 576

Query: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEV 1641
            I   P       ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y +
Sbjct: 577  ITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635

Query: 1642 LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE 1701
             + E    +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E
Sbjct: 636  EISEAM-RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691

Query: 1702 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
             S  RY LI+TA+D  P      TST TV + V D+NDN P F         V E +   
Sbjct: 692  -STDRYILIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 746

Query: 1762 RVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
             V    A D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L +
Sbjct: 747  FVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVV 801

Query: 1822 CARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
             A D  + P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G
Sbjct: 802  VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 861

Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------P 1935
             N  +++ I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P
Sbjct: 862  AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 919

Query: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
             IA      + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD    
Sbjct: 920  GIA-----TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGL 970

Query: 1996 AV--VTYQLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-- 2047
                V Y++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  
Sbjct: 971  PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEP 1026

Query: 2048 LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGE 2103
            +++S+A + I +L   +  P F+         E  PP  S L    T       + +N  
Sbjct: 1027 VMSSSATVKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQS 1078

Query: 2104 LVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLS 2155
            +VY I +G  +D F I+ +TGVI V N  +D E + SY L V A     V         S
Sbjct: 1079 IVYSIVSGNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137

Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVG 2213
             TA V I I D N+  P F        V E A   T +  + A D D      + Y ++ 
Sbjct: 1138 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1197

Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNAS 2265
               K+         ++ F V   TG +        M +S    +++AT +    +   A 
Sbjct: 1198 PPIKEG--------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249

Query: 2266 DLPERSVSVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
             L    VSV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1250 VL----VSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1297



 Score =  220 bits (561), Expect = 2e-56
 Identities = 254/924 (27%), Positives = 404/924 (43%), Gaps = 105/924 (11%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD-----------NDPL 65
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D            DP 
Sbjct: 395  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE 452

Query: 66   VFGVSGEEASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQ 121
            +     +  S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQ
Sbjct: 453  LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQ 510

Query: 122  VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAI 180
            V D NDN PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I
Sbjct: 511  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570

Query: 181  DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIF 236
            +   G++T+   ++    + Y LTV A   D   P     ++  +  +V        P F
Sbjct: 571  NKTTGLITIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRF 628

Query: 237  INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLN 296
              L YS  I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL 
Sbjct: 629  PQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLG 685

Query: 297  GLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSV 355
              LDRE+   +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++
Sbjct: 686  KALDRES---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNL 737

Query: 356  AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
            ++ E     F      QV   D + G+N     Y +GN ++ F I+           I  
Sbjct: 738  SVVEEEANAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYT 785

Query: 416  AIPLDYETVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV 473
            A+ L+ E  D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+
Sbjct: 786  AVKLNREVRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844

Query: 474  TVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----Q 527
              GT++L + A D D G    VSY       +  F+L   TG + L+  LDYE       
Sbjct: 845  PAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902

Query: 528  RFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 585
              T  + A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A
Sbjct: 903  SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 962

Query: 586  TDEDSP--PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
             D D P  P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V
Sbjct: 963  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVV 1018

Query: 642  MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDR 700
            +A D G P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++
Sbjct: 1019 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077

Query: 701  SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGH 755
            S  Y   SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +  
Sbjct: 1078 SIVY---SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1133

Query: 756  NQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
              K+  A V I + D N++ P ++   Y   + E     + V  V A D D G    + Y
Sbjct: 1134 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1193

Query: 816  S-IQPPNK----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
              I PP K     + + + TG I+T  AML             +  V++  D G+     
Sbjct: 1194 RLIIPPIKEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GL 1244

Query: 871  TSSATVFVNLLDLNDNDPTFQNLP 894
            +  A V V++++  D      N+P
Sbjct: 1245 SGKADVLVSVVNQLDMQVIVSNVP 1268



 Score =  218 bits (555), Expect = 8e-56
 Identities = 278/1062 (26%), Positives = 454/1062 (42%), Gaps = 142/1062 (13%)

Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
            ++  F+N+T       R LDR+  P    +I V+    N ++    Y  + I + D NDN
Sbjct: 96   KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148

Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
             P F   +Y A V E +P GT + T  +G   A D D      + Y +         +  
Sbjct: 149  SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 208

Query: 2010 FDIN-SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
            F+I    TG + +R  +  + +     I++    A+++     +T  L + +LD +D  P
Sbjct: 209  FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268

Query: 2068 TFSPATLT-----------------VHLLENCPPGFSVLQVTATDEDSGLNGE-----LV 2105
             F P  L                  +   E   P      + A D+D  +        ++
Sbjct: 269  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328

Query: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
            Y I  G  +     F +H  T  + +    ++R+  + + L + A      PL   A + 
Sbjct: 329  YSILVGTPEDYPRFFHMHPRTAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 387

Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
            I I D N+  P F  P     +LESA  G  I++         I A+D D+    +    
Sbjct: 388  IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE---DVPPS 444

Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
            G+  KD    L  N   +      TG    + +  P++RE   TY  +++  D   +   
Sbjct: 445  GVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--- 501

Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
               S P   + + V+D NDNTP F       Y   +     PG ++I + AVD D+G NG
Sbjct: 502  ---SEP-VIVNIQVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 554

Query: 2330 LVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIP 2387
             +TY +L      ++   + + G +     V+         TV+A+DN  P   R +   
Sbjct: 555  EITYEILVGAQGDFI--INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612

Query: 2388 VYLEIVDINDNN-PIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDG 2444
            VY+E++  N+ + P F Q  Y   + E + VG ++L + ATD +  +   I Y++  GD 
Sbjct: 613  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDP 669

Query: 2445 ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVND 2504
            +  F ++ TTG + +  +LDRE  D YIL   A D   D  S    N     I V DVND
Sbjct: 670  QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVND 724

Query: 2505 CRPQFSK--PQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
              P F    P+ + SV E E A   V  + ATD D G NG++ YSL G     F +  + 
Sbjct: 725  NAPVFDPYLPR-NLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNG 781

Query: 2563 GLVTT---QRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
             + T     R ++ Y  + L VVATDG   P   T  L ++V+D++DN PVF      T+
Sbjct: 782  SIYTAVKLNREVRDY--YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 838

Query: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
            L + E +P  + + ++ A D D G N + R    +        FF + P +G +   + L
Sbjct: 839  L-VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSL 892

Query: 2680 DRES----QAVYSLILVASDLGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQ 2731
            D E+    +A  + ++ A D+     Y TM P    + V ++D++D  P+F         
Sbjct: 893  DYEAFPDQEASITFLVEAFDI-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRI 942

Query: 2732 YQLLTVPEHSPRGTLVGNVTGAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLL 2786
            Y+ +  P+ + +GT +  V  A DAD    P + V Y    +        F ++ D   +
Sbjct: 943  YKGMVAPD-AVKGTPITTVY-AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000

Query: 2787 VLR-DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPR 2845
            + R +L+ E   IF  +V A  +    P    S T+ +   L L    +         PR
Sbjct: 1001 ITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKI---LVLHPGEI---------PR 1046

Query: 2846 FTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILA 2887
            FT+ EY     ++      ++ V++  A    N  + YSI++
Sbjct: 1047 FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVS 1085


>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
          Length = 1915

 Score =  301 bits (770), Expect = 9e-81
 Identities = 329/1159 (28%), Positives = 527/1159 (45%), Gaps = 143/1159 (12%)

Query: 224  IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI 283
            I++ D  D  P F +  Y   + E +P GTT+                 +T  SG+  + 
Sbjct: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTI-----------------FTGFSGDNGAT 177

Query: 284  FALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343
               D  +G +      + ++P          +   LN+ RT      TTT  + V+D +D
Sbjct: 178  DIDDGPNGQIEYVIQYNPDDP---------DRAQNLNERRT-----TTTTLTVDVLDGDD 223

Query: 344  NAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVVDKDENLGLNS--- 384
              P F       N+ +     Y  AI EL       P+     IQ +D+D N+   S   
Sbjct: 224  LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283

Query: 385  -MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
             +    LVG    +   F + P + +      + +  P++ +   ++D  + A +     
Sbjct: 284  GILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKFDLVIKAEQDNGHP 337

Query: 441  V-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------TSVLTVLATDNDAG 490
            +  +A + I +++EN+  P F+ P Y   + E+  VG         TS L ++A D D  
Sbjct: 338  LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 397

Query: 491  TFG--EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR 546
                 E+  F +D    F++ +   T  + L+  +D E  Q +T +I A DG  E     
Sbjct: 398  DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI 457

Query: 547  VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAF 606
            V I V+D NDN PTF + +Y   +  +      +++L A D D   N +ITY I+     
Sbjct: 458  VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----V 513

Query: 607  GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPP--LNSTVPVTIEVFDE 664
            G+  D  + +  G+I+++  +  E I      LTV A D   P    NS   V IEV   
Sbjct: 514  GAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571

Query: 665  ND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE-GSTQ--FR 720
            N+ +PP F +  Y + + E +  GA +L L ATD +       +SI Y++E G  Q  F 
Sbjct: 572  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG------DSITYAIENGDPQRVFN 625

Query: 721  INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
            ++  +G +T    LDRE+   YILI+ A DG       T  ATVNI + D+NDN P +  
Sbjct: 626  LSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDP 682

Query: 781  -APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
              P  +++VE    ++ V  V A DPD G NG + YS+   N  + + S  G I T    
Sbjct: 683  YLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VK 739

Query: 840  LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
            L+RE  D +E      +VV  TD    P  +T   T+ + +LD++DN P F N  +   V
Sbjct: 740  LNREVRDYYE------LVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLV 791

Query: 900  LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
             E +PAG +I Q+ A D+D G N  VSYR+     +  F ++  +G +     LD E   
Sbjct: 792  EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 849

Query: 960  EYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
            + +  +     A D         +T+T+ V D+ND  P F   +Y   V+ D  +   + 
Sbjct: 850  DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 909

Query: 1016 WLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
             +   D D  GL A  + Y +           F V      V T V L+ E T  + L++
Sbjct: 910  TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969

Query: 1071 EAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATD 1128
             A D+G PV    + +ATV + VL   +  P F Q  Y    V E   +G  +  + A  
Sbjct: 970  VAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAA 1025

Query: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-- 1186
             ++     + Y I+ GN  + F I+   G++     PLD E  +S+VL V+A + ++   
Sbjct: 1026 INQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLA 1080

Query: 1187 ----PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
                P +S+  +V + ++D N+  PVF ++ Y   G+ E A + TSV+ V+ATD+D+G+ 
Sbjct: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNY 1139

Query: 1242 GLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
             ++ YR++      G EG F ++  TGLI T        ++ +   V ATD       G 
Sbjct: 1140 SVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1198

Query: 1297 CSVYITLLNELDEAVQFSN 1315
              V ++++N+LD  V  SN
Sbjct: 1199 ADVLVSVVNQLDMQVIVSN 1217



 Score =  293 bits (750), Expect = 2e-78
 Identities = 313/1164 (26%), Positives = 505/1164 (43%), Gaps = 134/1164 (11%)

Query: 833  IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
            + +T  +LDR+ P       +  IVV V  C    +       V + + D NDN PTF++
Sbjct: 96   LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 893  LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVV 947
              + A V E  P G +I+        A D+D+G NG + Y                   V
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-------------------V 190

Query: 948  VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV-------- 999
            +     D +R      R          +++T+TLT+ VLD +D  P F P V        
Sbjct: 191  IQYNPDDPDRAQNLNER----------RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 240

Query: 1000 ----YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITGGNVDGK--- 1042
                Y  ++ E   P E   +     +   D D  +        + Y I  G  +     
Sbjct: 241  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300

Query: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
            F +  R A +  +  ++R+    + L+++A  +   G      A + + +LD N+  P F
Sbjct: 301  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEILDENNQSPYF 358

Query: 1103 LQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1153
               SY+  + E  P G +I         L++ A D D  +       +   ++ + F + 
Sbjct: 359  TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV- 417

Query: 1154 VSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRVIVYVEDINDEAPVFTQ 1210
               G+   +   +P+DRE   ++   + A++   G   S  V V + V D ND  P F +
Sbjct: 418  TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 474

Query: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY 1270
              Y      +    G SVI + A D D G  G + Y IL GA+G F I+++TGLI     
Sbjct: 475  ISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 533

Query: 1271 LDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV-QFSNASYEAAILENLA 1327
            ++     +Y + V A D APP  +    C+VYI +L   +++  +F    Y   I E + 
Sbjct: 534  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593

Query: 1328 LGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL 1387
            +G  ++ +QA   +  + ITY   A  +   + +F +   TG++T+   +DRE  D Y L
Sbjct: 594  VGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649

Query: 1388 TVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
             + A DG P   ST  V I V D NDN+P FD      +S+ E+      V  VKA DPD
Sbjct: 650  IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708

Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
            AG NGQV +SL  GN    F I     S G ++ A  L+RE  D+Y L VVA+D    PR
Sbjct: 709  AGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762

Query: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567
                 L + +LDI+DN PV  +   Y V V EN+  GT ++Q+ A D D+G N  +SY I
Sbjct: 763  HSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI 819

Query: 1568 TEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
                    F +   +GE++        A PD+E  S   LV   +  GT      T V V
Sbjct: 820  RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAFDIYGTMPPGIAT-VTV 877

Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG--PNGTVTYAIVAGNI 1679
             + D ND  P+F +  Y+ ++   PD +  T + T+ A D D    P   V Y +     
Sbjct: 878  IVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935

Query: 1680 ---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVND 1736
                + F ++   G +     L+ E +     ++V   D  P++S    S+ TV + V  
Sbjct: 936  PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS----SSATVKILVLH 991

Query: 1737 INDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
              + +P F ++   P  V+E    G  V    A    +  N  + YSI+ G+    F I+
Sbjct: 992  PGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGIN 1046

Query: 1796 PVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPV 1850
             + GV+ V   ++ +  T     +   +L +   +  +P  S+T  V I + D N++ PV
Sbjct: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106

Query: 1851 LLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGI 1907
                     +SE++ + + V  V A+D D+G  + + + +        +  F +   TG+
Sbjct: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166

Query: 1908 VTVNRPLDRERIPEYKLTISVKDN 1931
            +         R   +K  +   D+
Sbjct: 1167 IKTAMLFHNMRRSYFKFQVIATDD 1190



 Score =  283 bits (724), Expect = 2e-75
 Identities = 309/1079 (28%), Positives = 479/1079 (44%), Gaps = 108/1079 (10%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
             Y  Q    +   D  R      + L+   T    LTV+  D D   P+       +++ 
Sbjct: 188  EYVIQ----YNPDDPDRA-----QNLNERRTTTTTLTVDVLDGDDLGPMFLPC---VLVP 235

Query: 228  DVQDMDPIF-------INLPYSTNIYEHSPPGTTVRIITAIDQDKG------RPRGIGYT 274
            + +D  P+        +  P   N    +PP      I AIDQD+       RP GI Y+
Sbjct: 236  NTRDCRPLTYQAAIPELRTPEELNPIIVTPP------IQAIDQDRNIQPPSDRP-GILYS 288

Query: 275  IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
            I+ G         ++        LL+  N  +   F L +K  + N    P+ A +    
Sbjct: 289  ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---- 344

Query: 335  NILVIDINDNAPEFNSSEYSVAITELAQVGFAL--------PLFIQVVDKDENLGLNSMF 386
            +I ++D N+ +P F    Y   I E A VG  +        PL I  +DKD     +   
Sbjct: 345  HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404

Query: 387  EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKV 446
             ++L  + +  F ++ T +       + +  P+D E    Y F + A + V +      V
Sbjct: 405  HLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTYTFSITAFDGVQESEPVI-V 458

Query: 447  KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR 505
             I +++ NDN P F +  Y++ +Y ++  G SV+ + A D D G+ GE++Y         
Sbjct: 459  NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 518

Query: 506  FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEETTGRVRINVLDVND-NVPT 560
            F ++K TGLI +   ++  + + + LT+ A D         +   V I VL  N+ + P 
Sbjct: 519  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578

Query: 561  FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
            F +  Y   + E       L+ L+ATD +    + ITY+I +      +   +L E  G+
Sbjct: 579  FPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF---NLSETTGI 632

Query: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF--- 677
            +++ + LD E       Y+ ++    G P   ST  V I V D NDN P F    Y    
Sbjct: 633  LTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD--PYLPRN 687

Query: 678  VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-STQFRINARSGEITTTSLLDR 736
            +SVVE   A A V  + ATD D     GQ  + YSL   +  FRI + +G I T   L+R
Sbjct: 688  LSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNNLFRITS-NGSIYTAVKLNR 742

Query: 737  ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796
            E +  Y L+V A DG V     T   T+ I +LDI+DN P + ++ Y + + E  P  + 
Sbjct: 743  EVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800

Query: 797  VTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
            +  + A D DLG N  + Y I+ P    F++L+  TG++    + LD E     EA +  
Sbjct: 801  ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS-LDYEAFPDQEASITF 857

Query: 855  KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
             +         PP      ATV V + D+ND  P F    +   V      G  I  V A
Sbjct: 858  LVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 913

Query: 915  IDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
             D D  GL    V YR   +    P   F +   SG V+T   L+ E    ++L VVA D
Sbjct: 914  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 973

Query: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
             G P  SS++T+ I VL    E P F    Y      ++  +  +V +    +   +N  
Sbjct: 974  DGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATKGTMVGV---ISAAAINQS 1029

Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA------IDNGPVGKRHT 1083
            + Y I  GN +  F +     V+     LD ET  +Y+L ++A      + N  V  + +
Sbjct: 1030 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-S 1088

Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
             TA V++ + D N++ P+F +  Y   V ED     S+L++KATD D G +  + YR++
Sbjct: 1089 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147



 Score =  278 bits (712), Expect = 5e-74
 Identities = 345/1336 (25%), Positives = 580/1336 (43%), Gaps = 160/1336 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNI- 1890
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1891 -TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPE-NPRIARRDYDLLLIF 1948
                + +RA             + L+  R     LT+ V D  +  P        L  + 
Sbjct: 193  YNPDDPDRA-------------QNLNERRTTTTTLTVDVLDGDDLGPMF------LPCVL 233

Query: 1949 LSDENDNHPLFTKSTYQAEVME-NSPAGTPLTVLNGPILALDADQDIY------AVVTYQ 2001
            + +  D  PL    TYQA + E  +P      ++  PI A+D D++I        ++   
Sbjct: 234  VPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289

Query: 2002 LLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-LNSTAHLLI 2057
            L+G        F ++  T  +++   V  D   F      ++   +D G  L + A L I
Sbjct: 290  LVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQDNGHPLPAFAGLHI 346

Query: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTATDEDSGLNGELVYRI 2108
             ILD+N+  P F+  +   ++LE+ P G ++         L++ A D+D     +    +
Sbjct: 347  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 406

Query: 2109 EAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166
                         TG+ R       +DREEQ++Y  ++ A D   V  S   IV I + D
Sbjct: 407  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 464

Query: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLV 2224
             ND+ P F      V V     PG  +  +TA+D D   N ++ Y I           LV
Sbjct: 465  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-----------LV 513

Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
              Q D F +N  TG + +   +   +  TY +T+   DNA    ER  S+    + + VL
Sbjct: 514  GAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ERRNSI--CTVYIEVL 569

Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
              N+ +P   P  + Y +E I E    G  L+ + A D +      +TY + +  P    
Sbjct: 570  PPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF 624

Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
             L +++ G +   + +D E        + ASD G P   +   V + + D+NDN P+FD 
Sbjct: 625  NLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 682

Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
               +     +      +  V ATD D+G    + YSLG+  + F I  + G IY    L+
Sbjct: 683  YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLN 741

Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
            RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+   ++  V EN PA
Sbjct: 742  REVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 797

Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF------ 2577
            GT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R L  YE F      
Sbjct: 798  GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQEAS 854

Query: 2578 -SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
             +  V A D  G  PP  G   + V V D+ND  PVF +     +  +  +    + +  
Sbjct: 855  ITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPITT 910

Query: 2635 VYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILV 2692
            VYA D D  GL  + VRY             F ++  SG + T   L+ E   ++ L++V
Sbjct: 911  VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 970

Query: 2693 ASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTG 2752
            A D G+PV   +     + L       P F +      +Y+   V E + +GT+VG ++ 
Sbjct: 971  AFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVISA 1023

Query: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSW 2811
            A       N  + Y I +GNEE  F +    G + V   LD E    +   V+A S    
Sbjct: 1024 AAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1078

Query: 2812 TPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLAL 2871
                     L + +     +V + ++D N+ PP F K  Y  GV+ DA++ + +++V A 
Sbjct: 1079 LA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132

Query: 2872 DADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVD 2931
            D D GN     YS++A   +R +    ++  + F + +  G+++T  LF      YF   
Sbjct: 1133 DKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1184

Query: 2932 IVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL-----SN 2981
            ++A D     L+G  D  +  +  L  D +V IV N  P  V    E+   +L       
Sbjct: 1185 VIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQEQ 1241

Query: 2982 ITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLR 3039
            I GA  +V +   + H D     ++ + +L ++ ++  TNR +D + + + +D     + 
Sbjct: 1242 IPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDIN 1301

Query: 3040 NLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVLMN 3087
              F+ Y      +L+++   +V    +  + +   + A++ LA ++ L    A+L VL++
Sbjct: 1302 KDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVS 1361

Query: 3088 WYYRTVHKRKLKAIVA 3103
            +  R     K   I A
Sbjct: 1362 YRQRQAECTKTARIQA 1377



 Score =  276 bits (705), Expect = 3e-73
 Identities = 334/1235 (27%), Positives = 520/1235 (42%), Gaps = 134/1235 (10%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
              Y   + EL  VG  +           D D+  G N   E Y++  N       P   Q
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIE-YVIQYNPD----DPDRAQ 202

Query: 407  GKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQ---P 463
               + R          TVD  D D      +P         + + N  D RP+  Q   P
Sbjct: 203  NLNERRTTTTTL----TVDVLDGDDLGPMFLPC--------VLVPNTRDCRPLTYQAAIP 250

Query: 464  LYNISLYENVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLI 515
                    N  + T  +  +  D +     +   + Y        D P  F +   T  +
Sbjct: 251  ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL 310

Query: 516  MLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALREN 573
             L+  ++ +  Q+F L I A    G        + I +LD N+  P F   +Y G + E+
Sbjct: 311  SLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 370

Query: 574  EP---------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVS 624
             P         ++T  +R+ A D+D          +   + + S F ++       +++ 
Sbjct: 371  APVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLL 429

Query: 625  RPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
            +P+D E+       +T       + P    V V I+V D NDN PTF + +Y V V  ++
Sbjct: 430  QPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDM 485

Query: 685  MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY 742
              G +V+ L A D D   E     I Y +    Q  F IN  +G IT    ++      Y
Sbjct: 486  RPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTY 542

Query: 743  ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVV 801
             L V+A D      ++  I TV I +L  N+  P  +    Y + + E     + +  + 
Sbjct: 543  ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQ 602

Query: 802  AVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 859
            A D    E  ++ Y+I+   P + ++L+ TTG I T    LDRE+ D       R I++ 
Sbjct: 603  ATDR---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILII 651

Query: 860  VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLD 918
                GRP    TS+ATV + + D+NDN P F   LP    V+E   A   + QV A D D
Sbjct: 652  TASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708

Query: 919  EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
             G+NG V Y +  G     F I +S+G + T  +L+RE    Y+L VVA+D     + ST
Sbjct: 709  AGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765

Query: 979  STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
             TL I VLD++D +P F  + Y V V E++P    ++ +   D D+G N  +SY I    
Sbjct: 766  LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 823

Query: 1039 VDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
            V   F++      +  +  LD E      A+   ++EA D    G    G ATV V V D
Sbjct: 824  VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKD 881

Query: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNN 1149
            +ND  P+F +  Y+  V  D  +G  I  + A DAD       RV YR   +      + 
Sbjct: 882  MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941

Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1209
            F +   +G ++     L+ E  +   L+V A++     M SS  V + V     E P FT
Sbjct: 942  FEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFT 999

Query: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITV 1268
            Q++Y    + E A  GT V V+ A   +      + Y I+SG  E  F I+  TG+I   
Sbjct: 1000 QEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVN 1055

Query: 1269 NYLDYETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
              LDYET+TSY++ V A        +   P       VYI + +E +    F    Y   
Sbjct: 1056 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1115

Query: 1322 ILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
            + E+  + T ++RV+A   D  N + + YR       + K  F ++  TG+I    L   
Sbjct: 1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1175

Query: 1380 EKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1176 MRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210



 Score =  261 bits (666), Expect = 1e-68
 Identities = 307/1154 (26%), Positives = 501/1154 (43%), Gaps = 133/1154 (11%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LA-SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
            +  + +     + +    +         LD ++L    L  V        R   +   + 
Sbjct: 191  IQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 250

Query: 1517 ILDIND--NPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV-----LSYYITE 1569
             L   +  NP ++  P                   ++A D+D  I        + Y I  
Sbjct: 251  ELRTPEELNPIIVTPP-------------------IQAIDQDRNIQPPSDRPGILYSILV 291

Query: 1570 GNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626
            G  +     F M   + E++    P +R+    + LV   E +    L A   +++ I+D
Sbjct: 292  GTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 350

Query: 1627 ENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLITIQALDLDEGPNGTVTYAIVAGN 1678
            EN+ +P F  P Y+  +L+  P      D+LN TS + I ALD D          +   +
Sbjct: 351  ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410

Query: 1679 IVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVN 1735
              + F + +  G+   +T  + +D E     YT  +TA D        +  +  V+VN+ 
Sbjct: 411  YTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSITAFDG-------VQESEPVIVNIQ 461

Query: 1736 --DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
              D NDN PTFP      +  T+ +PG  V    A D D G NG++ Y I+ G   G+F+
Sbjct: 462  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFI 520

Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVL 1851
            I+   G++ +   VE+       Y LT+ A D   P    +S   V I VL  N+  P  
Sbjct: 521  INKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578

Query: 1852 L-NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV 1910
               L  ++ ISE   V + + ++ A+D +      +T+ I  G+ +R F ++ TTGI+T+
Sbjct: 579  FPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTL 635

Query: 1911 NRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVM 1969
             + LDRE    Y L I+  D  P+    A  +     I ++D NDN P+F     +   +
Sbjct: 636  GKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPRNLSV 690

Query: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029
                A   +    G + A D D  I   V Y L G  + LF I S+  + T    V ++R
Sbjct: 691  VEEEANAFV----GQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTA---VKLNR 742

Query: 2030 EAFSPPILELLLLAED--IGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFS 2087
            E       EL+++A D  +   +ST  L I +LD +DN P F+ +T TV + EN P G +
Sbjct: 743  EVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800

Query: 2088 VLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG---VIRVGNATIDREEQESYRLT 2143
            +LQ+ A D D G N  + YRI +     F  +H  TG   ++R  +     +++ S    
Sbjct: 801  ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 858

Query: 2144 VVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
            V A D  GT+P  G A VT+++ D+ND  P F   I    V   A  GT I  + A D D
Sbjct: 859  VEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917

Query: 2203 LN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTL 2258
                   ++ Y +      DD     P     F V  ++G V+ +  +N E    +++ +
Sbjct: 918  PPGLPASRVRYRV------DDVQ--FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969

Query: 2259 SVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFKPFGITYYMERILEGATPGTTLIA 2317
               D+          V ++  TV +L ++    P+F      Y    + E AT GT +  
Sbjct: 970  VAFDDGEP-------VMSSSATVKILVLHPGEIPRFTQE--EYRPPPVSELATKGTMVGV 1020

Query: 2318 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE-------EVHWLNF 2370
            ++A      +N  + Y+++         + + + G +  N  +DYE        V   + 
Sbjct: 1021 ISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVIYVNGPLDYETRTSYVLRVQADSL 1075

Query: 2371 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2430
             V  ++   P ++    VY+EI D N++ P+F +  Y   V ED  + T +L V ATD D
Sbjct: 1076 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1135

Query: 2431 SGNFALIEYSL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2485
            +GN++++ Y L      +G+  F +   TG I         ++ ++    +A D+ G   
Sbjct: 1136 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1195

Query: 2486 SNRRENSVQVVIQV 2499
            S + +  V VV Q+
Sbjct: 1196 SGKADVLVSVVNQL 1209



 Score =  252 bits (644), Expect = 4e-66
 Identities = 297/1095 (27%), Positives = 471/1095 (43%), Gaps = 141/1095 (12%)

Query: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
            V + V D NDN PTF  +  Y    E+T    G  ++T  + D      D GPNGQ+EY 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1783 IM--DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
            I     DP                +   L+        LT+   D     L    L  + 
Sbjct: 191  IQYNPDDP---------------DRAQNLNERRTTTTTLTVDVLDGD--DLGPMFLPCVL 233

Query: 1841 VLDINDNDPVLLN--LPMNITISENSPVSSFVAHVLASDADSGCNAR-----LTFNITAG 1893
            V +  D  P+     +P   T  E +P+      + A D D           + ++I  G
Sbjct: 234  VPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAIDQDRNIQPPSDRPGILYSILVG 292

Query: 1894 NRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
              E   R F ++  T  +++  P++R+   ++ L I  + +  +P  A   +  L I + 
Sbjct: 293  TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA---FAGLHIEIL 349

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPILALDADQDIYAVVTYQLLGAQS 2007
            DEN+  P FT  +YQ  ++E++P G  ++    L  P+  +  D+DI      +L     
Sbjct: 350  DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL----- 404

Query: 2008 GLFDINSSTGVVTV-RSGVI--------IDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
             LF +N  T V TV ++G+         +DRE          + A D    +    + I 
Sbjct: 405  HLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE--EQQTYTFSITAFDGVQESEPVIVNIQ 461

Query: 2059 ILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLI 2118
            ++D NDN PTF   +  V++  +  PG SV+Q+TA D D G NGE+ Y I  GAQ  F+I
Sbjct: 462  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 521

Query: 2119 HLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI---NDSRPEFL 2175
            +  TG+I +    ++     +Y LTV A D         +I T+ I+ +   N S P F 
Sbjct: 522  NKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580

Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
              + ++ + E+   G V+ N+ A D + +      I   +   D  R+       F ++ 
Sbjct: 581  QLMYSLEISEAMRVGAVLLNLQATDREGD-----SITYAIENGDPQRV-------FNLSE 628

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP 2295
             TG + +   ++RE    Y + ++  D   D          A + + V DVNDN P F P
Sbjct: 629  TTGILTLGKALDRESTDRYILIITASDGRPD------GTSTATVNIVVTDVNDNAPVFDP 682

Query: 2296 FGITYYMERILEGATPGTTLIA--VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
                 Y+ R L             V A DPD G+NG V Y+L +      +    S    
Sbjct: 683  -----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA 737

Query: 2354 VIANRTV-DYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
            V  NR V DY E+      V A+D    PR + + + ++++DI+DN+P+F   +Y   V 
Sbjct: 738  VKLNREVRDYYEL-----VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 792

Query: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDH 2470
            E++P GT IL + A D D G  A + Y +   E K  FA++P TG++ +L SLD E    
Sbjct: 793  ENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 850

Query: 2471 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVIT 2530
               +        D+          V + V D+ND  P FSK  +   V  +   GT + T
Sbjct: 851  QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 910

Query: 2531 MMATDQDEG--PNGELTYSLEGP----GVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVV 2582
            + A D D    P   + Y ++          F V+ DSG V T+  L       F L VV
Sbjct: 911  VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 970

Query: 2583 ATDGGEPPLWGTTMLLVEVIDVNDNRPVFV----RPPNGTILHIREEIPLRSNVYEVYAT 2638
            A D GEP +  +  + + V+   +  P F     RPP  +      E+  +  +  V + 
Sbjct: 971  AFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS------ELATKGTMVGVISA 1023

Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY-------SLIL 2691
                 +N ++ YS +  +GN + + F I+ I+G+I     LD E++  Y       SL +
Sbjct: 1024 ---AAINQSIVYSIV--SGNEE-DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1077

Query: 2692 VASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVT 2751
            V ++L  P    T    +V +E  D+N      PP    ++ +  V E +   T V  V 
Sbjct: 1078 VLANLRVPSKSNT---AKVYIEIQDENN----HPPVFQKKFYIGGVSEDARMFTSVLRVK 1130

Query: 2752 GAVDADEGPNAIVYY 2766
             A D D G  +++ Y
Sbjct: 1131 -ATDKDTGNYSVMAY 1144



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 353  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 411  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 468

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 469  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 528

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 529  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 587  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 643

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 644  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 696  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 743

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 744  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 803  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 860

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 861  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 920

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 921  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 976

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 977  PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1032

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1033 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1091

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1092 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1151

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1152 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1202

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1203 VSVVNQLDMQVIVSNVP 1219



 Score =  213 bits (542), Expect = 3e-54
 Identities = 272/1042 (26%), Positives = 440/1042 (42%), Gaps = 146/1042 (14%)

Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
            ++  F+N+T       R LDR+  P    +I V+    N ++    Y  + I + D NDN
Sbjct: 91   KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143

Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL---GAQSGLFD 2011
             P F   +Y A V E +P GT + T  +G   A D D      + Y +           +
Sbjct: 144  SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQN 203

Query: 2012 INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRP-TFS 2070
            +N      T  +  ++D +   P  L  +L                 + +  D RP T+ 
Sbjct: 204  LNERRTTTTTLTVDVLDGDDLGPMFLPCVL-----------------VPNTRDCRPLTYQ 246

Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGE-----LVYRIEAGAQDR----FLIHLV 2121
             A   +   E   P      + A D+D  +        ++Y I  G  +     F +H  
Sbjct: 247  AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPR 306

Query: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
            T  + +    ++R+  + + L + A      PL   A + I I D N+  P F  P    
Sbjct: 307  TAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG 365

Query: 2182 SVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
             +LESA  G  I++         I A+D D+             KD    L  N   +  
Sbjct: 366  YILESAPVGATISDSLNLTSPLRIVALDKDIED----------TKDPELHLFLNDYTSVF 415

Query: 2233 VNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
                TG    + +  P++RE   TY  +++  D   +      S P   + + V+D NDN
Sbjct: 416  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE------SEP-VIVNIQVMDANDN 468

Query: 2290 TPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
            TP F       Y   +     PG ++I + AVD D+G NG +TY +L      ++   + 
Sbjct: 469  TPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI--INK 523

Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIPVYLEIVDINDNN-PIFDQPS 2406
            + G +     V+         TV+A+DN  P   R +   VY+E++  N+ + P F Q  
Sbjct: 524  TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583

Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLD 2464
            Y   + E + VG ++L + ATD +  +   I Y++  GD +  F ++ TTG + +  +LD
Sbjct: 584  YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALD 640

Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK--PQFSTSVYENE 2522
            RE  D YIL   A D   D  S    N     I V DVND  P F    P+ + SV E E
Sbjct: 641  RESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPR-NLSVVEEE 694

Query: 2523 PAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT---QRPLQSYEKFSL 2579
             A   V  + ATD D G NG++ YSL G     F +  +  + T     R ++ Y  + L
Sbjct: 695  -ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTAVKLNREVRDY--YEL 750

Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
             VVATDG   P   T  L ++V+D++DN PVF      T+L + E +P  + + ++ A D
Sbjct: 751  VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTVL-VEENLPAGTTILQIEAKD 808

Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES----QAVYSLILVASD 2695
             D G N + R    +        FF + P +G +   + LD E+    +A  + ++ A D
Sbjct: 809  VDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863

Query: 2696 LGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVT 2751
            +     Y TM P    + V ++D++D  P+F         Y+ +  P+ + +GT +  V 
Sbjct: 864  I-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRIYKGMVAPD-AVKGTPITTVY 912

Query: 2752 GAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLLVLR-DLDREREAIFSFIVKA 2805
             A DAD    P + V Y    +        F ++ D   ++ R +L+ E   IF  +V A
Sbjct: 913  -AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971

Query: 2806 SSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSEL 2865
              +    P    S T+ +   L L    +         PRFT+ EY     ++      +
Sbjct: 972  FDDGE--PVMSSSATVKI---LVLHPGEI---------PRFTQEEYRPPPVSELATKGTM 1017

Query: 2866 IQVLALDADIGNNSLVFYSILA 2887
            + V++  A    N  + YSI++
Sbjct: 1018 VGVISAAA---INQSIVYSIVS 1036


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 548  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 595  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 648  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 766  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 879  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 935  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 106  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 166  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 226  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 286  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 345  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 401  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 455

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 456  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 515  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 575  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 632  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 685

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 686  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 739

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 740  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 796

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 797  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 855  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 909

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 910  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 970  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1028

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1029 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1086 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1145 KATDKDTGNYSVMAYRLI 1162



 Score =  286 bits (732), Expect = 2e-76
 Identities = 346/1350 (25%), Positives = 584/1350 (43%), Gaps = 151/1350 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 231  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 291  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 347

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 348  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 408  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 465

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 466  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 526  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 572

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 573  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 625

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 626  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 684  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 743

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 744  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 798

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 799  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 856

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 857  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 912

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 913  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 972  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1024

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1025 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1079

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1080 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1133

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1134 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1185

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1186 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1242

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1243 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1302

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1303 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1362

Query: 3077 FLA---AMLFVLMNWYYRTVHKRKLKAIVA 3103
             L    A+L VL+++  R     K   I A
Sbjct: 1363 ILCCIPAILVVLVSYRQRQAECTKTARIQA 1392



 Score =  279 bits (714), Expect = 3e-74
 Identities = 330/1231 (26%), Positives = 525/1231 (42%), Gaps = 128/1231 (10%)

Query: 265  KGRPRGIGYTI---VSGNTNSIFALDYISGVLTLNG---LLDRENPLYSHGFILTVKGTE 318
            KG   G   TI   +  N +    +D +  +L LN    +LDR+ P+  H  ++ V+   
Sbjct: 41   KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCIN 100

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ----VV 374
                       +     I+V D NDN+P F    Y   + EL  VG  +           
Sbjct: 101  KK-----VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155

Query: 375  DKDENLGLNSMFEVYLVGN----NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
            D D+  G N   E  +  N     S+     P  + G   +R R    L+YE   RY   
Sbjct: 156  DIDD--GPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKR----LNYEDKTRYFVI 209

Query: 431  LFANESVPD----HVGYAKVKITLINENDNRPIF-----------SQPL-YNISLYE--- 471
            + AN+   +          + + +++ +D  P+F            +PL Y  ++ E   
Sbjct: 210  IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 269

Query: 472  ----NVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLIMLIA 519
                N  + T  +  +  D +     +   + Y        D P  F +   T  + L+ 
Sbjct: 270  PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 329

Query: 520  RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEP-- 575
             ++ +  Q+F L I A    G        + I +LD N+  P F   +Y G + E+ P  
Sbjct: 330  PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 389

Query: 576  -------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
                   ++T  +R+ A D+D          +   + + S F ++       +++ +P+D
Sbjct: 390  ATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVD 448

Query: 629  YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
             E+       +T       + P    V V I+V D NDN PTF + +Y V V  ++  G 
Sbjct: 449  REEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 504

Query: 689  TVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIV 746
            +V+ L A D D   E     I Y +    Q  F IN  +G IT    ++      Y L V
Sbjct: 505  SVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTV 561

Query: 747  RAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDP 805
            +A D      ++  I TV I +L  N+  P  +    Y + + E     + +  + A D 
Sbjct: 562  QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 621

Query: 806  DLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
               E  ++ Y+I+   P + ++L+ TTG I T    LDRE+ D       R I++     
Sbjct: 622  ---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILIITASD 670

Query: 864  GRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
            GRP    TS+ATV + + D+NDN P F   LP    V+E   A   + QV A D D G+N
Sbjct: 671  GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN 727

Query: 923  GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
            G V Y +  G     F I +S+G + T  +L+RE    Y+L VVA+D     + ST TL 
Sbjct: 728  GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 784

Query: 983  IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
            I VLD++D +P F  + Y V V E++P    ++ +   D D+G N  +SY I    V   
Sbjct: 785  IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 842

Query: 1043 FSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
            F++      +  +  LD E      A+   ++EA D    G    G ATV V V D+ND 
Sbjct: 843  FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDY 900

Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNNFRIH 1153
             P+F +  Y+  V  D  +G  I  + A DAD       RV YR   +      + F + 
Sbjct: 901  PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960

Query: 1154 VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY 1213
              +G ++     L+ E  +   L+V A++     M SS  V + V     E P FTQ++Y
Sbjct: 961  EDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEY 1018

Query: 1214 SRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLD 1272
                + E A  GT V V+ A   +      + Y I+SG  E  F I+  TG+I     LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074

Query: 1273 YETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
            YET+TSY++ V A        +   P       VYI + +E +    F    Y   + E+
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1134

Query: 1326 LALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGD 1383
              + T ++RV+A   D  N + + YR       + K  F ++  TG+I    L    +  
Sbjct: 1135 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1194

Query: 1384 FYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
            ++   V+A DD G  +     V ++V+++ D
Sbjct: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 110  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 168

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 169  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 224  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 284  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 342

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 343  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 403  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 460

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 461  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 514  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 570

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 571  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 627

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 628  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 682

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 683  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 737

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 738  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 793  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 850

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 851  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 909

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 910  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 961

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 962  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1014

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1015 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1067

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 79   RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 135

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 136  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 196  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 316  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 376  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 435  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 490

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 491  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 549

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 550  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 607

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 608  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 663

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 664  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 720  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 774

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 775  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 832

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 833  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 888

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 889  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 943

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 944  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 999

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1000 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1051

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1052 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1169

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1170 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1218

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1219 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1263



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 368  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 426  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 484  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 544  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 602  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 659  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 711  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 759  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 818  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 876  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 936  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 991

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 992  PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1047

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1048 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1167 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1217

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1218 VSVVNQLDMQVIVSNVP 1234



 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 123/509 (24%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 2437 IEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAS--------NR 2488
            IE SL D    + +      +  L+S  R          L +D P ++ S        N+
Sbjct: 51   IELSLKDNVDYWVLMDPVKQMLFLNSTGR---------VLDRDPPMNIHSIVVQVQCINK 101

Query: 2489 RENSV---QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM-----ATDQDEGP 2540
            +  ++   +V I V D ND  P F    +  +V E  P GT++ T       ATD D+GP
Sbjct: 102  KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 161

Query: 2541 NGELTYSLE-----GPGVEAFHVD-MDSGLVTTQRPLQSYEK--FSLTVVATDGGE---P 2589
            NG++ Y ++         + F +  M +G +  ++ L   +K  + + + A D  +    
Sbjct: 162  NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 221

Query: 2590 PLWGTTMLLVEVIDVNDNRPVF---VRPPN----------GTILHIREEIPLRSNVYE-- 2634
                TT L V+V+D +D  P+F   V  PN            I  +R    L   +    
Sbjct: 222  RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 281

Query: 2635 VYATDKDEGLNG-----AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
            + A D+D  +        + YS L         FF + P +  +   + ++R+    + L
Sbjct: 282  IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341

Query: 2690 ILVAS-DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
            ++ A  D G P+P      L + + D ++  P F  P   S Q  +L   E +P G  + 
Sbjct: 342  VIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMP---SYQGYIL---ESAPVGATIS 393

Query: 2749 ---NVTG-----AVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC---LLVLRDLDREREA 2797
               N+T      A+D D          +   +    F +   G    L +L+ +DRE + 
Sbjct: 394  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             ++F + A                D V +     V + + D ND  P F +  Y   V T
Sbjct: 454  TYTFSITA---------------FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSIL 2886
            D + G  +IQ+ A+DAD G+N  + Y IL
Sbjct: 499  DMRPGDSVIQLTAVDADEGSNGEITYEIL 527


>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
          Length = 1677

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 548  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 595  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 648  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 766  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 879  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 935  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
          Length = 1682

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 133  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 193  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 253  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 313  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 372  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 428  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 482

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 483  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 541

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 542  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 601

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 602  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 658

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 659  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 712

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 713  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 766

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 767  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 823

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 824  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 881

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 882  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 936

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 937  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 996

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 997  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1055

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1056 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1113 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1172 KATDKDTGNYSVMAYRLI 1189



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 138  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 258  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 318  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 375  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 435  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 492

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 493  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 553  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 599

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 600  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 652

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 653  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 710

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 711  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 770

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 771  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 825

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 826  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 883

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 884  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 939

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 940  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 998

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 999  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1051

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1052 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1106

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1107 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1160

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1161 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1212

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1213 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1269

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1270 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1329

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1330 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1389

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1390 ILCCIPAILVVLVSY 1404



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 44   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 100  FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 155  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 213  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 269  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 329  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 389  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 448

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 449  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 503

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 504  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 560

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 561  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 620

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 621  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 676

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 677  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 727

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 728  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 783

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 784  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 843

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 844  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 901

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 902  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 960  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1018

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1019 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1073

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 137  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 196  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 251  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 311  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 370  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 430  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 487

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 488  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 541  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 597

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 598  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 654

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 655  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 709

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 710  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 764

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 765  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 820  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 877

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 878  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 936

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 937  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 988

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 989  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1041

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1042 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1094

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1095 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1154

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1155 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1214

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1215 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 106  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 163  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 223  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 283  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 343  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 403  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 462  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 517

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 518  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 576

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 577  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 634

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 635  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 690

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 691  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 746

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 747  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 801

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 802  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 859

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 860  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 915

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 916  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 970

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 971  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1026

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1027 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1078

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1079 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1196

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1197 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1245

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1246 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1290



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 395  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 452

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 453  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 510

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 511  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 570

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 571  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 629  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 685

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 686  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 738  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 785

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 786  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 844

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 845  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 903  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 963  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1018

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1019 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1074

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1075 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1194 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1244

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1245 VSVVNQLDMQVIVSNVP 1261



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 45   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 105  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 155

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 156  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 215

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 216  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 276  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 336  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 393

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 394  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 447

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 448  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 492

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 493  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552

Query: 2885 IL 2886
            IL
Sbjct: 553  IL 554


>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
          Length = 1539

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 548  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 595  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 648  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 766  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 879  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 935  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
          Length = 1935

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 106  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 166  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 226  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 286  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 345  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 401  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 455

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 456  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 515  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 575  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 632  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 685

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 686  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 739

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 740  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 796

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 797  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 855  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 909

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 910  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 970  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1028

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1029 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1086 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1145 KATDKDTGNYSVMAYRLI 1162



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 111  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 171  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 231  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 291  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 347

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 348  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 408  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 465

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 466  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 526  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 572

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 573  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 625

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 626  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 684  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 743

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 744  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 798

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 799  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 856

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 857  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 912

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 913  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 972  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1024

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1025 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1079

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1080 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1133

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1134 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1185

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1186 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1242

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1243 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1302

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1303 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1362

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1363 ILCCIPAILVVLVSY 1377



 Score =  279 bits (714), Expect = 3e-74
 Identities = 330/1231 (26%), Positives = 525/1231 (42%), Gaps = 128/1231 (10%)

Query: 265  KGRPRGIGYTI---VSGNTNSIFALDYISGVLTLNG---LLDRENPLYSHGFILTVKGTE 318
            KG   G   TI   +  N +    +D +  +L LN    +LDR+ P+  H  ++ V+   
Sbjct: 41   KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCIN 100

Query: 319  LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ----VV 374
                       +     I+V D NDN+P F    Y   + EL  VG  +           
Sbjct: 101  KK-----VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155

Query: 375  DKDENLGLNSMFEVYLVGN----NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
            D D+  G N   E  +  N     S+     P  + G   +R R    L+YE   RY   
Sbjct: 156  DIDD--GPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKR----LNYEDKTRYFVI 209

Query: 431  LFANESVPD----HVGYAKVKITLINENDNRPIF-----------SQPL-YNISLYE--- 471
            + AN+   +          + + +++ +D  P+F            +PL Y  ++ E   
Sbjct: 210  IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 269

Query: 472  ----NVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLIMLIA 519
                N  + T  +  +  D +     +   + Y        D P  F +   T  + L+ 
Sbjct: 270  PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 329

Query: 520  RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEP-- 575
             ++ +  Q+F L I A    G        + I +LD N+  P F   +Y G + E+ P  
Sbjct: 330  PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 389

Query: 576  -------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
                   ++T  +R+ A D+D          +   + + S F ++       +++ +P+D
Sbjct: 390  ATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVD 448

Query: 629  YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
             E+       +T       + P    V V I+V D NDN PTF + +Y V V  ++  G 
Sbjct: 449  REEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 504

Query: 689  TVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIV 746
            +V+ L A D D   E     I Y +    Q  F IN  +G IT    ++      Y L V
Sbjct: 505  SVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTV 561

Query: 747  RAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDP 805
            +A D      ++  I TV I +L  N+  P  +    Y + + E     + +  + A D 
Sbjct: 562  QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 621

Query: 806  DLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
               E  ++ Y+I+   P + ++L+ TTG I T    LDRE+ D       R I++     
Sbjct: 622  ---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILIITASD 670

Query: 864  GRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
            GRP    TS+ATV + + D+NDN P F   LP    V+E   A   + QV A D D G+N
Sbjct: 671  GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN 727

Query: 923  GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
            G V Y +  G     F I +S+G + T  +L+RE    Y+L VVA+D     + ST TL 
Sbjct: 728  GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 784

Query: 983  IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
            I VLD++D +P F  + Y V V E++P    ++ +   D D+G N  +SY I    V   
Sbjct: 785  IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 842

Query: 1043 FSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
            F++      +  +  LD E      A+   ++EA D    G    G ATV V V D+ND 
Sbjct: 843  FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDY 900

Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNNFRIH 1153
             P+F +  Y+  V  D  +G  I  + A DAD       RV YR   +      + F + 
Sbjct: 901  PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960

Query: 1154 VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY 1213
              +G ++     L+ E  +   L+V A++     M SS  V + V     E P FTQ++Y
Sbjct: 961  EDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEY 1018

Query: 1214 SRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLD 1272
                + E A  GT V V+ A   +      + Y I+SG  E  F I+  TG+I     LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074

Query: 1273 YETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
            YET+TSY++ V A        +   P       VYI + +E +    F    Y   + E+
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1134

Query: 1326 LALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGD 1383
              + T ++RV+A   D  N + + YR       + K  F ++  TG+I    L    +  
Sbjct: 1135 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1194

Query: 1384 FYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
            ++   V+A DD G  +     V ++V+++ D
Sbjct: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 110  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 168

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 169  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 224  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 284  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 342

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 343  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 403  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 460

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 461  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 514  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 570

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 571  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 627

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 628  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 682

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 683  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 737

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 738  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 793  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 850

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 851  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 909

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 910  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 961

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 962  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1014

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1015 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1067

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 79   RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 135

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 136  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 196  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 316  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 376  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 435  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 490

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 491  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 549

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 550  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 607

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 608  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 663

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 664  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 720  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 774

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 775  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 832

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 833  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 888

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 889  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 943

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 944  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 999

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1000 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1051

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1052 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1169

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1170 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1218

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1219 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1263



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 368  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 426  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 484  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 544  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 602  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 659  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 711  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 759  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 818  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 876  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 936  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 991

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 992  PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1047

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1048 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1167 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1217

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1218 VSVVNQLDMQVIVSNVP 1234



 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 123/509 (24%), Positives = 205/509 (40%), Gaps = 91/509 (17%)

Query: 2437 IEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAS--------NR 2488
            IE SL D    + +      +  L+S  R          L +D P ++ S        N+
Sbjct: 51   IELSLKDNVDYWVLMDPVKQMLFLNSTGR---------VLDRDPPMNIHSIVVQVQCINK 101

Query: 2489 RENSV---QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM-----ATDQDEGP 2540
            +  ++   +V I V D ND  P F    +  +V E  P GT++ T       ATD D+GP
Sbjct: 102  KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 161

Query: 2541 NGELTYSLE-----GPGVEAFHVD-MDSGLVTTQRPLQSYEK--FSLTVVATDGGE---P 2589
            NG++ Y ++         + F +  M +G +  ++ L   +K  + + + A D  +    
Sbjct: 162  NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 221

Query: 2590 PLWGTTMLLVEVIDVNDNRPVF---VRPPN----------GTILHIREEIPLRSNVYE-- 2634
                TT L V+V+D +D  P+F   V  PN            I  +R    L   +    
Sbjct: 222  RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 281

Query: 2635 VYATDKDEGLNG-----AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
            + A D+D  +        + YS L         FF + P +  +   + ++R+    + L
Sbjct: 282  IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341

Query: 2690 ILVAS-DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
            ++ A  D G P+P      L + + D ++  P F  P   S Q  +L   E +P G  + 
Sbjct: 342  VIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMP---SYQGYIL---ESAPVGATIS 393

Query: 2749 ---NVTG-----AVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC---LLVLRDLDREREA 2797
               N+T      A+D D          +   +    F +   G    L +L+ +DRE + 
Sbjct: 394  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             ++F + A                D V +     V + + D ND  P F +  Y   V T
Sbjct: 454  TYTFSITA---------------FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSIL 2886
            D + G  +IQ+ A+DAD G+N  + Y IL
Sbjct: 499  DMRPGDSVIQLTAVDADEGSNGEITYEIL 527


>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
          Length = 1952

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184



 Score =  286 bits (732), Expect = 2e-76
 Identities = 346/1350 (25%), Positives = 584/1350 (43%), Gaps = 151/1350 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 548  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 595  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 648  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 766  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 879  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 935  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384

Query: 3077 FLA---AMLFVLMNWYYRTVHKRKLKAIVA 3103
             L    A+L VL+++  R     K   I A
Sbjct: 1385 ILCCIPAILVVLVSYRQRQAECTKTARIQA 1414



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
          Length = 1957

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 548  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 595  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 648  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 766  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 879  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 935  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
          Length = 1962

 Score =  290 bits (743), Expect = 1e-77
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 133  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192

Query: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 193  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252

Query: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 253  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 313  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 372  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 428  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 482

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 483  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 541

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 542  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 601

Query: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 602  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 658

Query: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 659  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 712

Query: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 713  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 766

Query: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 767  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 823

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 824  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 881

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 882  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 936

Query: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 937  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 996

Query: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 997  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1055

Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1056 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112

Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1113 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171

Query: 1125 KATDADEGEFGRVWYRIL 1142
            KATD D G +  + YR++
Sbjct: 1172 KATDKDTGNYSVMAYRLI 1189



 Score =  284 bits (727), Expect = 9e-76
 Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)

Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 138  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197

Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 198  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257

Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 258  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317

Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
            I        ++   L+G        F ++  T  +++   V  D   F      ++   +
Sbjct: 318  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374

Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
            D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ A 
Sbjct: 375  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434

Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
            D+D     +    +             TG+ R       +DREEQ++Y  ++ A D   V
Sbjct: 435  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 492

Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
              S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ Y 
Sbjct: 493  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552

Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
            I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    ER
Sbjct: 553  I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 599

Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
              S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +      
Sbjct: 600  RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 652

Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
            +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V +
Sbjct: 653  ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 710

Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
             + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F I
Sbjct: 711  VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 770

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
              + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P F+
Sbjct: 771  T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 825

Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
               ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++  R
Sbjct: 826  NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 883

Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
             L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     + 
Sbjct: 884  SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 939

Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
             +  +    + +  VYA D D  GL  + VRY             F ++  SG + T   
Sbjct: 940  -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 998

Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
            L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   V 
Sbjct: 999  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1051

Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
            E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E   
Sbjct: 1052 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1106

Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
             +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV+ 
Sbjct: 1107 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1160

Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
            DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++T 
Sbjct: 1161 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1212

Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
             LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V    
Sbjct: 1213 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1269

Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
            E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D +
Sbjct: 1270 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1329

Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
             + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA ++
Sbjct: 1330 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1389

Query: 3077 FLA---AMLFVLMNW 3088
             L    A+L VL+++
Sbjct: 1390 ILCCIPAILVVLVSY 1404



 Score =  280 bits (716), Expect = 2e-74
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 44   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 100  FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 155  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 213  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 269  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 329  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 389  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 448

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 449  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 503

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 504  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 560

Query: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 561  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 620

Query: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 621  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 676

Query: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 677  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 727

Query: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 728  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 783

Query: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 784  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 843

Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 844  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 901

Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 902  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959

Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 960  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1018

Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1019 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1073

Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133

Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193

Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252



 Score =  275 bits (703), Expect = 6e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 137  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 196  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250

Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 251  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 311  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 370  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 430  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 487

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 488  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 541  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 597

Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 598  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 654

Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 655  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 709

Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 710  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 764

Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 765  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819

Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 820  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 877

Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 878  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 936

Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 937  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 988

Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 989  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1041

Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 1042 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1094

Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 1095 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1154

Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 1155 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1214

Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 1215 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251



 Score =  274 bits (700), Expect = 1e-72
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 106  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162

Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 163  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222

Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 223  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282

Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 283  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342

Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 343  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402

Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 403  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 462  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 517

Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 518  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 576

Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 577  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 634

Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 635  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 690

Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 691  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 746

Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 747  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 801

Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 802  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 859

Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 860  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 915

Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 916  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 970

Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 971  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1026

Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 1027 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1078

Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 1079 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137

Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1196

Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 1197 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1245

Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 1246 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1290



 Score =  223 bits (568), Expect = 2e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 395  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 452

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 453  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 510

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 511  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 570

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 571  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628

Query: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 629  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 685

Query: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 686  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737

Query: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 738  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 785

Query: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 786  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 844

Query: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 845  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902

Query: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 903  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962

Query: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 963  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1018

Query: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 1019 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1074

Query: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 1075 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133

Query: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193

Query: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 1194 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1244

Query: 878  VNLLDLNDNDPTFQNLP 894
            V++++  D      N+P
Sbjct: 1245 VSVVNQLDMQVIVSNVP 1261



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 45   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 105  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 155

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 156  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 215

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 216  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 276  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 336  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 393

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 394  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 447

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 448  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 492

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 493  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552

Query: 2885 IL 2886
            IL
Sbjct: 553  IL 554


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  285 bits (730), Expect = 4e-76
 Identities = 241/789 (30%), Positives = 374/789 (47%), Gaps = 70/789 (8%)

Query: 1963 TYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLG--AQSGLFDINSSTGVVT 2020
            T + E+ EN P G     LN  I  ++A     A + Y+L+     + L  ++SSTG + 
Sbjct: 29   TIREELPENVPIGNIPKDLN--ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIF 86

Query: 2021 VRSGVIIDREAFSPPI-----------LELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
              S  I DRE                 LE+++L  D   L     + I + D NDN P F
Sbjct: 87   TTSNRI-DREKLCAGASYAEENECFFELEVVILPNDFFRL---IKIKIIVKDTNDNAPMF 142

Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR--- 2126
                + + + EN          +ATD D+G NG   Y +  G Q  F + +V        
Sbjct: 143  PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPEGEKW 201

Query: 2127 ---VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
               +    +DRE++++Y + +   D GT   S TAI+ + + D+ND+RP F      V +
Sbjct: 202  PQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHI 261

Query: 2184 LESAEPGTVIANITAIDHDLNPKLEY-HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
             E+A  GT +  + A D D+    E  +I G      T RL       FA+N  TG + V
Sbjct: 262  PENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-------FALNNTTGLITV 314

Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF------KPF 2296
            +  ++RE  A ++VT+   D +S  P R      A +T+NV DVNDN P         P 
Sbjct: 315  QRSLDREETAIHKVTVLASDGSST-PAR------ATVTINVTDVNDNPPNIDLRYIISPI 367

Query: 2297 GITYYMERILEGATPGTTLIAVAAV-DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
              T Y+        P  T IA+  V D D  +NG V    ++   P +++    +   + 
Sbjct: 368  NGTVYLSE----KDPVNTKIALITVSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLE 422

Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
             +  +DYE     +F + ASD+G P       V +++ D NDN PIF+QP  + +V E+ 
Sbjct: 423  TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
              G  + T++ATD DSG  A I Y LG   S F ++  TG +      DRE+++ +I T 
Sbjct: 483  RRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542

Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
             A+DN     +   ++   V++ VLD ND  P+F+   F   V EN P  ++V  +  TD
Sbjct: 543  TARDN----GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598

Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT--VVATDGGEPPLWG 2593
             D G N  +T S+     + F +D  SG++ +       ++ S T  V ATDGG+PP   
Sbjct: 599  ADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657

Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR----SNVYEVYATDKDEGLNGAVR 2649
            T  + + V+DVNDN PV + PP+ T   +   +PL     S V EV+A D D G+N  ++
Sbjct: 658  TAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVVAEVFAVDVDTGMNAELK 714

Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
            Y+ +  +GN     F IDP++G I   ++       ++ L++  SDLG P    T+  + 
Sbjct: 715  YTIV--SGNNK-GLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771

Query: 2710 VALEDIDDN 2718
            + + D   N
Sbjct: 772  LYVNDTAGN 780



 Score =  255 bits (652), Expect = 5e-67
 Identities = 202/683 (29%), Positives = 317/683 (46%), Gaps = 42/683 (6%)

Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
           P+D        I+V D NDNAP F S   +++I E   +    P+       D + G N 
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPI---PSATDPDTGFNG 175

Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGY 443
           +    L+   S   +    + +G+   ++ V   LD E  D Y   +   +   P     
Sbjct: 176 VQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST 235

Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD- 502
           A +++T+ + NDNRP+F +    + + EN  VGTSV+ + ATD D G+  E+ Y F    
Sbjct: 236 AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQV 295

Query: 503 ----PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
                  F+L+  TGLI +   LD E      +T++A DG        V INV DVNDN 
Sbjct: 296 APATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNP 355

Query: 559 PTFQKDAYVGA------LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDI 612
           P       +        L E +P  T++  +  +D+D+  N ++   I     F      
Sbjct: 356 PNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK--- 412

Query: 613 SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS 672
           ++Y+   ++  S  LDYE          ++A D+G P LN T  V +++ DENDNPP F+
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470

Query: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINARSGEITTT 731
           +P   +SV EN   G  +  ++ATD D  +      I+Y L   ++ F ++ ++G +T +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGK---NADIVYQLGPNASFFDLDRKTGVLTAS 527

Query: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
            + DRE +  +I  V A D G    Q    A V +T+LD NDN P +    +   + E  
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQ--AAVIVTVLDENDNSPKFTHNHFQFFVSENL 585

Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
           P  S V  +   D D GEN  +  SI   N  + L+  +G I+ ++   DRE    +  +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFD 644

Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF----QNLPFVAEVLEGIPAGV 907
                 V  TD G+PP   +S+A V +N++D+NDN P       N  F    L  IP  V
Sbjct: 645 ------VKATDGGQPP--RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696

Query: 908 SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA 967
            + +V A+D+D G+N  + Y +  G  +  F I+  +G +    +     +  ++L V  
Sbjct: 697 -VAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755

Query: 968 SDAGTPTKSSTSTLTIHVLDVND 990
           SD G P   S  TL +  L VND
Sbjct: 756 SDLGYP--KSLHTLVLVFLYVND 776



 Score =  236 bits (602), Expect = 3e-61
 Identities = 189/633 (29%), Positives = 303/633 (47%), Gaps = 45/633 (7%)

Query: 655  VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
            + + I V D NDN P F  P   +S+ EN +  +     +ATD D      Q   +  L 
Sbjct: 126  IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL--LN 183

Query: 715  GSTQFRINA-------RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNIT 767
            G + F ++        +  ++     LDRE K  Y++ ++  DGG    QK+  A + +T
Sbjct: 184  GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVT 241

Query: 768  LLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY----SIQPPNK- 822
            + D+NDN P +K+    +++ E  P  + V  + A D D+G N  + Y     + P  K 
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 823  FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLD 882
             ++LN+TTG I T    LDRE    H      K+ V  +D    P +    ATV +N+ D
Sbjct: 302  LFALNNTTGLI-TVQRSLDREETAIH------KVTVLASDGSSTPAR----ATVTINVTD 350

Query: 883  LNDNDPTFQNLPFVAEVLEGI-------PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
            +NDN P   +L ++   + G        P    I  +   D D  +NG V   +   +P 
Sbjct: 351  VNDNPPNI-DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409

Query: 936  MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
                +  +  ++ T++ LD E   E+  ++VASD+G P+ + T+ + + + D ND  P F
Sbjct: 410  HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469

Query: 996  FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
               V  +SVSE+  R   +  ++ TD D G NA++ Y +  G     F +  +  V+   
Sbjct: 470  NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527

Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
               DRE    ++  + A DNG    +    A V VTVLD NDN P F  + ++  V E++
Sbjct: 528  RVFDREEQERFIFTVTARDNGTPPLQ--SQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585

Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
            P+  ++  +  TDAD GE   V   IL+ N  +NF +   +G++ +     DRE+ SS+ 
Sbjct: 586  PKYSTVGVITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVI-KSNVSFDREQQSSYT 642

Query: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAP-VFTQQQYSRLGLRETAGIGTSVIV-VQA 1233
              V+A +    P  S+ +V + V D+ND +P V +    +   L   + I  SV+  V A
Sbjct: 643  FDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702

Query: 1234 TDRDSGDGGLVNYRILSG-AEGKFEIDESTGLI 1265
             D D+G    + Y I+SG  +G F ID  TG I
Sbjct: 703  VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735



 Score =  233 bits (593), Expect = 3e-60
 Identities = 209/703 (29%), Positives = 314/703 (44%), Gaps = 66/703 (9%)

Query: 117 KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
           K+ I V D NDNAP F +   ++ IPENT + +   I +ATDPD G  G   Y       
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186

Query: 177 FFAIDSARGI-------VTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV 229
            F +D            + V + LD E    Y + +   D    +  ST A L + ++DV
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST-AILQVTVSDV 245

Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFAL 286
            D  P+F       +I E++P GT+V  + A D D G    I Y     V+  T  +FAL
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305

Query: 287 DYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP 346
           +  +G++T+   LDRE        +L   G+      TP+ ATVT    I V D+NDN P
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSS-----TPARATVT----INVTDVNDNPP 356

Query: 347 EFNSSEY------SVAITELAQVGFALPLFIQVVDKDENLG------LNSMFEVYLVGNN 394
             +          +V ++E   V   + L I V DKD ++       +      +L    
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIAL-ITVSDKDTDVNGKVICFIEREVPFHLKAVY 415

Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINE 453
            + +++  +S+             LDYE    + F + A++S  P     A V++ L +E
Sbjct: 416 DNQYLLETSSL-------------LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462

Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
           NDN PIF+QP+  +S+ EN   G  + T+ ATD D+G   ++ Y    +   F LD+ TG
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTG 522

Query: 514 LIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
           ++      D E  +RF  T+ ARD G    ++   V + VLD NDN P F  + +   + 
Sbjct: 523 VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582

Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
           EN P  + +  +  TD D+  N  +T SI++ +     F +  Y   GVI  +   D EQ
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDN---DNFVLDPYS--GVIKSNVSFDREQ 637

Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP---AYFVSVVENIMAGA 688
            S+      V A D G PP +ST  VTI V D NDN P    P     F  V  + + G+
Sbjct: 638 QSS--YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695

Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
            V  + A D+D       +  I S      FRI+  +G IT            + L+V  
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755

Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
            D G        + T+ +  L +ND   T  +A Y  +L+  T
Sbjct: 756 SDLG----YPKSLHTLVLVFLYVND---TAGNASYIYDLIRRT 791



 Score =  230 bits (586), Expect = 2e-59
 Identities = 213/745 (28%), Positives = 338/745 (45%), Gaps = 70/745 (9%)

Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT--AGNRERAFFINATTGIVTVN 1911
            LP N+ I  N P    ++H+   +A +G +A L + +   AG+       ++T  I T +
Sbjct: 34   LPENVPIG-NIPKDLNISHI---NAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTS 89

Query: 1912 RPLDRERIPEYKLTISVKDNPENPR-------IARRDYDLLL---IFLSDENDNHPLFTK 1961
              +DRE     KL        EN         I   D+  L+   I + D NDN P+F  
Sbjct: 90   NRIDRE-----KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144

Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS--GLFDINSSTGVV 2019
                  + EN+   +   + +    A D D     V  Y+LL  QS  GL  + +  G  
Sbjct: 145  PVINISIPENTLINSRFPIPS----ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200

Query: 2020 TVRSGVI--IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
              +  V   +DRE     ++++ +        +STA L +T+ D NDNRP F    + VH
Sbjct: 201  WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260

Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVY----RIEAGAQDRFLIHLVTGVIRVGNATID 2133
            + EN P G SV+Q+ ATD D G N E+ Y    ++    +  F ++  TG+I V   ++D
Sbjct: 261  IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV-QRSLD 319

Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-----LNPIQTVSVLESAE 2188
            REE   +++TV+A+D  + P   T  VTI + D+ND+ P       ++PI     L   +
Sbjct: 320  REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377

Query: 2189 P-GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMN 2247
            P  T IA IT  D D +  +   ++  + ++    L    ++ +   + T S++      
Sbjct: 378  PVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYL--LETSSLL------ 427

Query: 2248 RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILE 2307
             +   T E +  ++ + S  P  + +   A + V + D NDN P F    I      + E
Sbjct: 428  -DYEGTKEFSFKIVASDSGKPSLNQT---ALVRVKLEDENDNPPIFNQPVIEL---SVSE 480

Query: 2308 GATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHW 2367
                G  L  ++A D D G N  + Y    L P       D   G + A+R  D EE   
Sbjct: 481  NNRRGLYLTTISATDEDSGKNADIVY---QLGPNASFFDLDRKTGVLTASRVFDREEQER 537

Query: 2368 LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427
              FTV A DNG+PP  ++  V + ++D NDN+P F    +Q  V E++P  + +  +T T
Sbjct: 538  FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597

Query: 2428 DADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
            DAD+G    +  S+ +    F ++P +G I    S DRE++  Y     A D        
Sbjct: 598  DADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDG----GQP 653

Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTS---VYENEPAGTSVITMMATDQDEGPNGEL 2544
             R ++ +V I V+DVND  P    P  +TS   V  +   G+ V  + A D D G N EL
Sbjct: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713

Query: 2545 TYSL-EGPGVEAFHVDMDSGLVTTQ 2568
             Y++  G     F +D  +G +T +
Sbjct: 714  KYTIVSGNNKGLFRIDPVTGNITLE 738



 Score =  230 bits (586), Expect = 2e-59
 Identities = 217/741 (29%), Positives = 328/741 (44%), Gaps = 76/741 (10%)

Query: 1361 LFKIDAITG-VITVQGLVDREK-----------GDFYTLTVVADDGGPKVDSTVKVYITV 1408
            L K+ + TG + T    +DREK             F+ L VV           +K+ I V
Sbjct: 75   LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND--FFRLIKIKIIV 132

Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFE 1468
             D NDN+P F     + +SIPE+  +  R     A DPD G NG   + L +G      +
Sbjct: 133  KDTNDNAPMFPSPVIN-ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191

Query: 1469 IVTT--NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1526
            IV T   +   ++ V + LDRE+ D Y++++   D GTP +    ILQVT+ D+NDN PV
Sbjct: 192  IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY----ITEGNKDMAFRMDRIS 1582
             +      V + EN   GT+V+Q+ ATD DIG N+ + Y     +    K + F ++  +
Sbjct: 252  FKEG-QVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTT 309

Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--- 1639
            G I  + +  DRE  +  H V  +  +G+ T +  T V + + D NDN P     +    
Sbjct: 310  GLITVQRSL-DREETAI-HKVTVLASDGSSTPARAT-VTINVTDVNDNPPNIDLRYIISP 366

Query: 1640 ---EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
                V L E  D +NT +  I   D D   NG V   I      +   +  +  ++  + 
Sbjct: 367  INGTVYLSE-KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425

Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE 1756
             LDYE +      IV +    P L+     T  V V + D NDN P F +          
Sbjct: 426  LLDYEGTKEFSFKIVASDSGKPSLNQ----TALVRVKLEDENDNPPIFNQPVIELSVSEN 481

Query: 1757 GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAF 1816
             + G  + T  A D DSG N  + Y +  G     F +    GVL   +    DRE    
Sbjct: 482  NRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR--VFDREEQER 537

Query: 1817 YNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
            +  T+ ARD G PPL S   V + VLD NDN P   +      +SEN P  S V  +  +
Sbjct: 538  FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597

Query: 1877 DADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
            DAD+G N  +T +I   N    F ++  +G++  N   DRE+   Y   +   D  + PR
Sbjct: 598  DADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655

Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT-----PLTVLNGPIL----A 1987
             +      + I + D NDN P          V+ + P+ T     PL+ + G ++    A
Sbjct: 656  SSTAK---VTINVMDVNDNSP----------VVISPPSNTSFKLVPLSAIPGSVVAEVFA 702

Query: 1988 LDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPP---ILELLLLA 2043
            +D D  + A + Y ++ G   GLF I+  TG +T+        E  +P    +  L++  
Sbjct: 703  VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL-------EEKPAPTDVGLHRLVVNI 755

Query: 2044 EDIGLLNSTAHLLITILDDND 2064
             D+G   S   L++  L  ND
Sbjct: 756  SDLGYPKSLHTLVLVFLYVND 776



 Score =  211 bits (538), Expect = 7e-54
 Identities = 210/761 (27%), Positives = 323/761 (42%), Gaps = 58/761 (7%)

Query: 792  PPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDREN---- 844
            P D +++ + A     G + +LVY +           ++S+TG+I TT   +DRE     
Sbjct: 44   PKDLNISHINAAT---GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAG 100

Query: 845  ---PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
                + +E     ++V+   D  R          + + + D NDN P F +      + E
Sbjct: 101  ASYAEENECFFELEVVILPNDFFR-------LIKIKIIVKDTNDNAPMFPSPVINISIPE 153

Query: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDF-LINSSSGV----VVTTTELDRE 956
                        A D D G NG+  Y +  G       ++ +  G     ++    LDRE
Sbjct: 154  NTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDRE 213

Query: 957  RIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
            +   Y +++   D GTP KSST+ L + V DVND  P F      V + E+ P    V+ 
Sbjct: 214  QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273

Query: 1017 LNCTDNDVGLNAELSYFITGGNV----DGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA 1072
            L+ TD D+G NAE+ Y I G  V       F++     ++     LDRE TA + + + A
Sbjct: 274  LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332

Query: 1073 IDNGPVGKRHTGTATVFVTVLDVNDNRP------IFLQSSYEASVPEDIPEGHSILQLKA 1126
             D    G      ATV + V DVNDN P      I    +    + E  P    I  +  
Sbjct: 333  SD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388

Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
            +D D    G+V    +      + +    N  L+     LD E        + A +    
Sbjct: 389  SDKDTDVNGKV-ICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447

Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
             +  +  V V +ED ND  P+F  Q    L + E    G  +  + ATD DSG    + Y
Sbjct: 448  SLNQTALVRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506

Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
            ++   A   F++D  TG++      D E +  ++  V+A D   P  Q   +V +T+L+E
Sbjct: 507  QLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565

Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
             D + +F++  ++  + ENL   + +  +     D         +          F +D 
Sbjct: 566  NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDP 622

Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRF--DFTSD 1423
             +GVI      DRE+   YT  V A DGG P   ST KV I V+D NDNSP      ++ 
Sbjct: 623  YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682

Query: 1424 SAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFV 1481
            S   +P     G  VA V A D D G N ++ +++ SGN  G F I  VT N ++ E   
Sbjct: 683  SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEE--- 739

Query: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
             +P   +   H ++ V  SD G P  K  H L +  L +ND
Sbjct: 740  -KPAPTDVGLHRLV-VNISDLGYP--KSLHTLVLVFLYVND 776



 Score =  202 bits (513), Expect = 6e-51
 Identities = 226/796 (28%), Positives = 337/796 (42%), Gaps = 94/796 (11%)

Query: 137 YSVR--IPENTPVGTPIFIVNATDPDLGAGGSV-----LYSFQPPSQFFAIDSARG-IVT 188
           Y++R  +PEN P+G     +N +  +   G S      L S    +    + S+ G I T
Sbjct: 28  YTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFT 87

Query: 189 VIRELDYETTQA-----------YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFI 237
               +D E   A           ++L V     D  R    L  + II+ D  D  P+F 
Sbjct: 88  TSNRIDREKLCAGASYAEENECFFELEVVILPNDFFR----LIKIKIIVKDTNDNAPMFP 143

Query: 238 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYIS------- 290
           +   + +I E++   +   I +A D D G      Y +++G   S+F LD +        
Sbjct: 144 SPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEGEKW 201

Query: 291 GVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             L +   LDRE       +++ +K   + D  TP  ++ T    + V D+NDN P F  
Sbjct: 202 PQLIVQQNLDREQ---KDTYVMKIK---VEDGGTPQKSS-TAILQVTVSDVNDNRPVFKE 254

Query: 351 SEYSVAITELAQVGFALPLFIQVVDKDENLGLNS----MFEVYLVGNNSHHFIISPTSVQ 406
            +  V I E A VG ++   IQ+   D ++G N+    +F   +       F ++ T+  
Sbjct: 255 GQVEVHIPENAPVGTSV---IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG- 310

Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANE--SVPDHVGYAKVKITLINENDNRP------ 458
                 I V   LD E    +   + A++  S P     A V I + + NDN P      
Sbjct: 311 -----LITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDLRY 362

Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PDRFSLDKDTG-LIM 516
           I S     + L E   V T +  +  +D D    G+V  F   + P       D   L+ 
Sbjct: 363 IISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE 422

Query: 517 LIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENE 574
             + LDYE  + F+  I+A D G      T  VR+ + D NDN P F +     ++ EN 
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 575 PSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN 634
                L  + ATDEDS  N  I Y +       S+FD+      GV++ SR  D E+   
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL---GPNASFFDLD--RKTGVLTASRVFDREEQER 537

Query: 635 GLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLN 694
                TV A D G PPL S   V + V DENDN P F+   +   V EN+   +TV  + 
Sbjct: 538 --FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595

Query: 695 ATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVG 754
            TD D      +   +  L  +  F ++  SG I +    DRE +S Y   V+A DGG  
Sbjct: 596 VTDADAGE--NKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653

Query: 755 HNQKTGIATVNITLLDINDNHPTWKDAP--YYINLVEMTP-PDSDVTTVVAVDPDLGENG 811
               T   T+N+  +D+NDN P     P      LV ++  P S V  V AVD D G N 
Sbjct: 654 PRSSTAKVTINV--MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 812 TLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLK 869
            L Y+I   N    + ++  TG I         E P P +  L R +VV+++D G P   
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITL------EEKPAPTDVGLHR-LVVNISDLGYP--- 761

Query: 870 ATSSATVFVNLLDLND 885
             S  T+ +  L +ND
Sbjct: 762 -KSLHTLVLVFLYVND 776



 Score =  191 bits (485), Expect = 1e-47
 Identities = 190/665 (28%), Positives = 304/665 (45%), Gaps = 82/665 (12%)

Query: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
            I + + + D NDN P+F  P    ++ E+  + +     +ATD D+G   +  Y L +G+
Sbjct: 126  IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185

Query: 2446 SKFAINPTTG-------DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
            S F ++            + V  +LDRE+KD Y++    +D      + ++ ++  + + 
Sbjct: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG----GTPQKSSTAILQVT 241

Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA--- 2555
            V DVND RP F + Q    + EN P GTSVI + ATD D G N E+ Y        A   
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 2556 -FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP--- 2609
             F ++  +GL+T QR L   E     +TV+A+DG   P   T  + + V DVNDN P   
Sbjct: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNID 359

Query: 2610 --VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI-- 2665
                + P NGT+ ++ E+ P+ + +  +  +DKD  +NG V   F++    R+  F +  
Sbjct: 360  LRYIISPINGTV-YLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIE----REVPFHLKA 413

Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
            +     L++T+  LD E    +S  +VASD G+P   +T   ++V LED +DN P+F +P
Sbjct: 414  VYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-VRVKLEDENDNPPIFNQP 472

Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGC 2784
                     L+V E++ RG  +  ++ A D D G NA + Y +  G     F L +  G 
Sbjct: 473  VIE------LSVSENNRRGLYLTTIS-ATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523

Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
            L   R  DRE +  F F V A  N   TPP                 V V + D ND  P
Sbjct: 524  LTASRVFDREEQERFIFTVTARDNG--TPPLQSQAA-----------VIVTVLDENDNSP 570

Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQV 2904
            +FT   +   V+ +    S +  +   DAD G N  V  SIL         ND+++    
Sbjct: 571  KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL---------NDNDN---- 617

Query: 2905 FTMGSMDGILRTFDLFMAYSPGYFVVDIVARD--LAGHNDTAIIGIYILRDDQRVKIVIN 2962
            F +    G++++   F       +  D+ A D      + TA + I ++  +    +VI+
Sbjct: 618  FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677

Query: 2963 EIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRIL 3022
              P     F+   +  LS I G++V      F VD    +N    EL   +V+ +   + 
Sbjct: 678  --PPSNTSFK---LVPLSAIPGSVVAE---VFAVDVDTGMN---AELKYTIVSGNNKGLF 726

Query: 3023 DVDRV 3027
             +D V
Sbjct: 727  RIDPV 731



 Score =  181 bits (459), Expect = 1e-44
 Identities = 178/627 (28%), Positives = 279/627 (44%), Gaps = 56/627 (8%)

Query: 69  VSGEEASRFFAVEPDTGVVW----LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQ 121
           ++G+       VE   G  W    ++Q LDRE K  + ++  V D    Q   T  + + 
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241

Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-----QPPSQ 176
           V DVNDN P F      V IPEN PVGT +  ++ATD D+G+   + Y F         +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 177 FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD----M 232
            FA+++  G++TV R LD E T  +++TV A+D   T      A + I +TDV D    +
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVTINVTDVNDNPPNI 358

Query: 233 DPIFINLPYSTNIY--EHSPPGTTVRIITAIDQD---KGRPRGIGYTIVSGNTNSIFALD 287
           D  +I  P +  +Y  E  P  T + +IT  D+D    G+        V  +  +++   
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418

Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
           Y+   L  + LLD E        I+       +D   PS    T    + + D NDN P 
Sbjct: 419 YL---LETSSLLDYEGTKEFSFKIVA------SDSGKPS-LNQTALVRVKLEDENDNPPI 468

Query: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
           FN     ++++E  + G  L     +   DE+ G N+   VY +G N+  F      +  
Sbjct: 469 FNQPVIELSVSENNRRGLYL---TTISATDEDSGKNADI-VYQLGPNASFF-----DLDR 519

Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYN 466
           K  + +  +   D E  +R+ F + A ++  P     A V +T+++ENDN P F+   + 
Sbjct: 520 KTGV-LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQ 578

Query: 467 ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELI 526
             + EN+   ++V  +  TD DAG    V+    +D D F LD  +G+I      D E  
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQ 638

Query: 527 QRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSV---TQLV 581
             +T  + A DGG     +T +V INV+DVNDN P         + +    S    + + 
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698

Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
            + A D D+  N ++ Y+IVS +  G +    +     +     P D      GL  L V
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDV-----GLHRLVV 753

Query: 642 MAMDAGNP-PLNSTVPVTIEVFDENDN 667
              D G P  L++ V V + V D   N
Sbjct: 754 NISDLGYPKSLHTLVLVFLYVNDTAGN 780



 Score =  150 bits (379), Expect = 2e-35
 Identities = 145/500 (29%), Positives = 222/500 (44%), Gaps = 47/500 (9%)

Query: 42  ISEDTPVGSSVTQLLAQDMD-----NDPLVFGVSGEEAS-RFFAVEPDTGVVWLRQPLDR 95
           I E+ PVG+SV QL A D D         +FG     A+ R FA+   TG++ +++ LDR
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDR 320

Query: 96  ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
           E  +   V    SD      R  V I V DVNDN P    +        +V + E  PV 
Sbjct: 321 EETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVN 380

Query: 149 TPIFIVNATDPDLGAGGSVL--YSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
           T I ++  +D D    G V+     + P    A+   + ++     LDYE T+ +   + 
Sbjct: 381 TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIV 440

Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
           A+D  K   L+  A + + + D  D  PIF       ++ E++  G  +  I+A D+D G
Sbjct: 441 ASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499

Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
           +   I Y +  G   S F LD  +GVLT + + DRE       FI TV   +       S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREE---QERFIFTVTARDNGTPPLQS 554

Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV---VDKDENLGLN 383
            A V  T    V+D NDN+P+F  + +   ++E       LP +  V      D + G N
Sbjct: 555 QAAVIVT----VLDENDNSPKFTHNHFQFFVSE------NLPKYSTVGVITVTDADAGEN 604

Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVG 442
               + ++ N++ +F++ P S   K++      +  D E    Y FD+ A +   P    
Sbjct: 605 KAVTLSIL-NDNDNFVLDPYSGVIKSN------VSFDREQQSSYTFDVKATDGGQPPRSS 657

Query: 443 YAKVKITLINENDNRPIFSQPLYNIS---LYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
            AKV I +++ NDN P+   P  N S   +  +   G+ V  V A D D G   E+ Y  
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717

Query: 500 --SDDPDRFSLDKDTGLIML 517
              ++   F +D  TG I L
Sbjct: 718 VSGNNKGLFRIDPVTGNITL 737



 Score =  145 bits (365), Expect = 9e-34
 Identities = 157/555 (28%), Positives = 238/555 (42%), Gaps = 65/555 (11%)

Query: 2408 QEAVFEDVPVGTII--LTVTATDADSGNFALIEYSLGD--GESKFA-INPTTGDIYVLSS 2462
            +E + E+VP+G I   L ++  +A +G  A + Y L    G++    ++ +TG+I+  S+
Sbjct: 31   REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 2463 -LDREKKDHYILTALAKDNPGD------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
             +DREK       + A++N         +  N     +++ I V D ND  P F  P  +
Sbjct: 91   RIDREKL--CAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG---------LVT 2566
             S+ EN    +      ATD D G NG   Y L   G   F +D+            +V 
Sbjct: 149  ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQ 207

Query: 2567 TQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI-LHIREE 2625
                 +  + + + +   DGG P    T +L V V DVNDNRPVF     G + +HI E 
Sbjct: 208  QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVF---KEGQVEVHIPEN 264

Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
             P+ ++V +++ATD D G N  +RY F           F ++  +GLI   + LDRE  A
Sbjct: 265  APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324

Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
            ++ + ++ASD G   P      + V   D++DN P        SP    + + E  P  T
Sbjct: 325  IHKVTVLASD-GSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP--DGCLLVLRD--LDREREAIFSF 2801
             +  +T   D D   N  V  FI     E  FHL+   D   L+     LD E    FSF
Sbjct: 382  KIALIT-VSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437

Query: 2802 IVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKV 2861
             + AS +          P+L+  A      VRV LED ND PP F +      V+ + + 
Sbjct: 438  KIVASDS--------GKPSLNQTA-----LVRVKLEDENDNPPIFNQPVIELSVSENNRR 484

Query: 2862 GSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFM 2921
            G  L  + A D D G N+ + Y +     F             F +    G+L    +F 
Sbjct: 485  GLYLTTISATDEDSGKNADIVYQLGPNASF-------------FDLDRKTGVLTASRVFD 531

Query: 2922 AYSPGYFVVDIVARD 2936
                  F+  + ARD
Sbjct: 532  REEQERFIFTVTARD 546


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  285 bits (730), Expect = 4e-76
 Identities = 241/789 (30%), Positives = 374/789 (47%), Gaps = 70/789 (8%)

Query: 1963 TYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLG--AQSGLFDINSSTGVVT 2020
            T + E+ EN P G     LN  I  ++A     A + Y+L+     + L  ++SSTG + 
Sbjct: 29   TIREELPENVPIGNIPKDLN--ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIF 86

Query: 2021 VRSGVIIDREAFSPPI-----------LELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
              S  I DRE                 LE+++L  D   L     + I + D NDN P F
Sbjct: 87   TTSNRI-DREKLCAGASYAEENECFFELEVVILPNDFFRL---IKIKIIVKDTNDNAPMF 142

Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR--- 2126
                + + + EN          +ATD D+G NG   Y +  G Q  F + +V        
Sbjct: 143  PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPEGEKW 201

Query: 2127 ---VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
               +    +DRE++++Y + +   D GT   S TAI+ + + D+ND+RP F      V +
Sbjct: 202  PQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHI 261

Query: 2184 LESAEPGTVIANITAIDHDLNPKLEY-HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
             E+A  GT +  + A D D+    E  +I G      T RL       FA+N  TG + V
Sbjct: 262  PENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-------FALNNTTGLITV 314

Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF------KPF 2296
            +  ++RE  A ++VT+   D +S  P R      A +T+NV DVNDN P         P 
Sbjct: 315  QRSLDREETAIHKVTVLASDGSST-PAR------ATVTINVTDVNDNPPNIDLRYIISPI 367

Query: 2297 GITYYMERILEGATPGTTLIAVAAV-DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
              T Y+        P  T IA+  V D D  +NG V    ++   P +++    +   + 
Sbjct: 368  NGTVYLSE----KDPVNTKIALITVSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLE 422

Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
             +  +DYE     +F + ASD+G P       V +++ D NDN PIF+QP  + +V E+ 
Sbjct: 423  TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
              G  + T++ATD DSG  A I Y LG   S F ++  TG +      DRE+++ +I T 
Sbjct: 483  RRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542

Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
             A+DN     +   ++   V++ VLD ND  P+F+   F   V EN P  ++V  +  TD
Sbjct: 543  TARDN----GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598

Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT--VVATDGGEPPLWG 2593
             D G N  +T S+     + F +D  SG++ +       ++ S T  V ATDGG+PP   
Sbjct: 599  ADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657

Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR----SNVYEVYATDKDEGLNGAVR 2649
            T  + + V+DVNDN PV + PP+ T   +   +PL     S V EV+A D D G+N  ++
Sbjct: 658  TAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVVAEVFAVDVDTGMNAELK 714

Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
            Y+ +  +GN     F IDP++G I   ++       ++ L++  SDLG P    T+  + 
Sbjct: 715  YTIV--SGNNK-GLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771

Query: 2710 VALEDIDDN 2718
            + + D   N
Sbjct: 772  LYVNDTAGN 780



 Score =  255 bits (652), Expect = 5e-67
 Identities = 202/683 (29%), Positives = 317/683 (46%), Gaps = 42/683 (6%)

Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
           P+D        I+V D NDNAP F S   +++I E   +    P+       D + G N 
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPI---PSATDPDTGFNG 175

Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGY 443
           +    L+   S   +    + +G+   ++ V   LD E  D Y   +   +   P     
Sbjct: 176 VQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST 235

Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD- 502
           A +++T+ + NDNRP+F +    + + EN  VGTSV+ + ATD D G+  E+ Y F    
Sbjct: 236 AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQV 295

Query: 503 ----PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
                  F+L+  TGLI +   LD E      +T++A DG        V INV DVNDN 
Sbjct: 296 APATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNP 355

Query: 559 PTFQKDAYVGA------LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDI 612
           P       +        L E +P  T++  +  +D+D+  N ++   I     F      
Sbjct: 356 PNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK--- 412

Query: 613 SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS 672
           ++Y+   ++  S  LDYE          ++A D+G P LN T  V +++ DENDNPP F+
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470

Query: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINARSGEITTT 731
           +P   +SV EN   G  +  ++ATD D  +      I+Y L   ++ F ++ ++G +T +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGK---NADIVYQLGPNASFFDLDRKTGVLTAS 527

Query: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
            + DRE +  +I  V A D G    Q    A V +T+LD NDN P +    +   + E  
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQ--AAVIVTVLDENDNSPKFTHNHFQFFVSENL 585

Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
           P  S V  +   D D GEN  +  SI   N  + L+  +G I+ ++   DRE    +  +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFD 644

Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF----QNLPFVAEVLEGIPAGV 907
                 V  TD G+PP   +S+A V +N++D+NDN P       N  F    L  IP  V
Sbjct: 645 ------VKATDGGQPP--RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696

Query: 908 SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA 967
            + +V A+D+D G+N  + Y +  G  +  F I+  +G +    +     +  ++L V  
Sbjct: 697 -VAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755

Query: 968 SDAGTPTKSSTSTLTIHVLDVND 990
           SD G P   S  TL +  L VND
Sbjct: 756 SDLGYP--KSLHTLVLVFLYVND 776



 Score =  236 bits (602), Expect = 3e-61
 Identities = 189/633 (29%), Positives = 303/633 (47%), Gaps = 45/633 (7%)

Query: 655  VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
            + + I V D NDN P F  P   +S+ EN +  +     +ATD D      Q   +  L 
Sbjct: 126  IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL--LN 183

Query: 715  GSTQFRINA-------RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNIT 767
            G + F ++        +  ++     LDRE K  Y++ ++  DGG    QK+  A + +T
Sbjct: 184  GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVT 241

Query: 768  LLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY----SIQPPNK- 822
            + D+NDN P +K+    +++ E  P  + V  + A D D+G N  + Y     + P  K 
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 823  FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLD 882
             ++LN+TTG I T    LDRE    H      K+ V  +D    P +    ATV +N+ D
Sbjct: 302  LFALNNTTGLI-TVQRSLDREETAIH------KVTVLASDGSSTPAR----ATVTINVTD 350

Query: 883  LNDNDPTFQNLPFVAEVLEGI-------PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
            +NDN P   +L ++   + G        P    I  +   D D  +NG V   +   +P 
Sbjct: 351  VNDNPPNI-DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409

Query: 936  MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
                +  +  ++ T++ LD E   E+  ++VASD+G P+ + T+ + + + D ND  P F
Sbjct: 410  HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469

Query: 996  FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
               V  +SVSE+  R   +  ++ TD D G NA++ Y +  G     F +  +  V+   
Sbjct: 470  NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527

Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
               DRE    ++  + A DNG    +    A V VTVLD NDN P F  + ++  V E++
Sbjct: 528  RVFDREEQERFIFTVTARDNGTPPLQ--SQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585

Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
            P+  ++  +  TDAD GE   V   IL+ N  +NF +   +G++ +     DRE+ SS+ 
Sbjct: 586  PKYSTVGVITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVI-KSNVSFDREQQSSYT 642

Query: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAP-VFTQQQYSRLGLRETAGIGTSVIV-VQA 1233
              V+A +    P  S+ +V + V D+ND +P V +    +   L   + I  SV+  V A
Sbjct: 643  FDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702

Query: 1234 TDRDSGDGGLVNYRILSG-AEGKFEIDESTGLI 1265
             D D+G    + Y I+SG  +G F ID  TG I
Sbjct: 703  VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735



 Score =  233 bits (593), Expect = 3e-60
 Identities = 209/703 (29%), Positives = 314/703 (44%), Gaps = 66/703 (9%)

Query: 117 KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
           K+ I V D NDNAP F +   ++ IPENT + +   I +ATDPD G  G   Y       
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186

Query: 177 FFAIDSARGI-------VTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV 229
            F +D            + V + LD E    Y + +   D    +  ST A L + ++DV
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST-AILQVTVSDV 245

Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFAL 286
            D  P+F       +I E++P GT+V  + A D D G    I Y     V+  T  +FAL
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305

Query: 287 DYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP 346
           +  +G++T+   LDRE        +L   G+      TP+ ATVT    I V D+NDN P
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSS-----TPARATVT----INVTDVNDNPP 356

Query: 347 EFNSSEY------SVAITELAQVGFALPLFIQVVDKDENLG------LNSMFEVYLVGNN 394
             +          +V ++E   V   + L I V DKD ++       +      +L    
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIAL-ITVSDKDTDVNGKVICFIEREVPFHLKAVY 415

Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINE 453
            + +++  +S+             LDYE    + F + A++S  P     A V++ L +E
Sbjct: 416 DNQYLLETSSL-------------LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462

Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
           NDN PIF+QP+  +S+ EN   G  + T+ ATD D+G   ++ Y    +   F LD+ TG
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTG 522

Query: 514 LIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
           ++      D E  +RF  T+ ARD G    ++   V + VLD NDN P F  + +   + 
Sbjct: 523 VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582

Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
           EN P  + +  +  TD D+  N  +T SI++ +     F +  Y   GVI  +   D EQ
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDN---DNFVLDPYS--GVIKSNVSFDREQ 637

Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP---AYFVSVVENIMAGA 688
            S+      V A D G PP +ST  VTI V D NDN P    P     F  V  + + G+
Sbjct: 638 QSS--YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695

Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
            V  + A D+D       +  I S      FRI+  +G IT            + L+V  
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755

Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
            D G        + T+ +  L +ND   T  +A Y  +L+  T
Sbjct: 756 SDLG----YPKSLHTLVLVFLYVND---TAGNASYIYDLIRRT 791



 Score =  230 bits (586), Expect = 2e-59
 Identities = 213/745 (28%), Positives = 338/745 (45%), Gaps = 70/745 (9%)

Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT--AGNRERAFFINATTGIVTVN 1911
            LP N+ I  N P    ++H+   +A +G +A L + +   AG+       ++T  I T +
Sbjct: 34   LPENVPIG-NIPKDLNISHI---NAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTS 89

Query: 1912 RPLDRERIPEYKLTISVKDNPENPR-------IARRDYDLLL---IFLSDENDNHPLFTK 1961
              +DRE     KL        EN         I   D+  L+   I + D NDN P+F  
Sbjct: 90   NRIDRE-----KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144

Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS--GLFDINSSTGVV 2019
                  + EN+   +   + +    A D D     V  Y+LL  QS  GL  + +  G  
Sbjct: 145  PVINISIPENTLINSRFPIPS----ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200

Query: 2020 TVRSGVI--IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
              +  V   +DRE     ++++ +        +STA L +T+ D NDNRP F    + VH
Sbjct: 201  WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260

Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVY----RIEAGAQDRFLIHLVTGVIRVGNATID 2133
            + EN P G SV+Q+ ATD D G N E+ Y    ++    +  F ++  TG+I V   ++D
Sbjct: 261  IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV-QRSLD 319

Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-----LNPIQTVSVLESAE 2188
            REE   +++TV+A+D  + P   T  VTI + D+ND+ P       ++PI     L   +
Sbjct: 320  REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377

Query: 2189 P-GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMN 2247
            P  T IA IT  D D +  +   ++  + ++    L    ++ +   + T S++      
Sbjct: 378  PVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYL--LETSSLL------ 427

Query: 2248 RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILE 2307
             +   T E +  ++ + S  P  + +   A + V + D NDN P F    I      + E
Sbjct: 428  -DYEGTKEFSFKIVASDSGKPSLNQT---ALVRVKLEDENDNPPIFNQPVIEL---SVSE 480

Query: 2308 GATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHW 2367
                G  L  ++A D D G N  + Y    L P       D   G + A+R  D EE   
Sbjct: 481  NNRRGLYLTTISATDEDSGKNADIVY---QLGPNASFFDLDRKTGVLTASRVFDREEQER 537

Query: 2368 LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427
              FTV A DNG+PP  ++  V + ++D NDN+P F    +Q  V E++P  + +  +T T
Sbjct: 538  FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597

Query: 2428 DADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
            DAD+G    +  S+ +    F ++P +G I    S DRE++  Y     A D        
Sbjct: 598  DADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDG----GQP 653

Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTS---VYENEPAGTSVITMMATDQDEGPNGEL 2544
             R ++ +V I V+DVND  P    P  +TS   V  +   G+ V  + A D D G N EL
Sbjct: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713

Query: 2545 TYSL-EGPGVEAFHVDMDSGLVTTQ 2568
             Y++  G     F +D  +G +T +
Sbjct: 714  KYTIVSGNNKGLFRIDPVTGNITLE 738



 Score =  230 bits (586), Expect = 2e-59
 Identities = 217/741 (29%), Positives = 328/741 (44%), Gaps = 76/741 (10%)

Query: 1361 LFKIDAITG-VITVQGLVDREK-----------GDFYTLTVVADDGGPKVDSTVKVYITV 1408
            L K+ + TG + T    +DREK             F+ L VV           +K+ I V
Sbjct: 75   LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND--FFRLIKIKIIV 132

Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFE 1468
             D NDN+P F     + +SIPE+  +  R     A DPD G NG   + L +G      +
Sbjct: 133  KDTNDNAPMFPSPVIN-ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191

Query: 1469 IVTT--NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1526
            IV T   +   ++ V + LDRE+ D Y++++   D GTP +    ILQVT+ D+NDN PV
Sbjct: 192  IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY----ITEGNKDMAFRMDRIS 1582
             +      V + EN   GT+V+Q+ ATD DIG N+ + Y     +    K + F ++  +
Sbjct: 252  FKEG-QVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTT 309

Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--- 1639
            G I  + +  DRE  +  H V  +  +G+ T +  T V + + D NDN P     +    
Sbjct: 310  GLITVQRSL-DREETAI-HKVTVLASDGSSTPARAT-VTINVTDVNDNPPNIDLRYIISP 366

Query: 1640 ---EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
                V L E  D +NT +  I   D D   NG V   I      +   +  +  ++  + 
Sbjct: 367  INGTVYLSE-KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425

Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE 1756
             LDYE +      IV +    P L+     T  V V + D NDN P F +          
Sbjct: 426  LLDYEGTKEFSFKIVASDSGKPSLNQ----TALVRVKLEDENDNPPIFNQPVIELSVSEN 481

Query: 1757 GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAF 1816
             + G  + T  A D DSG N  + Y +  G     F +    GVL   +    DRE    
Sbjct: 482  NRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR--VFDREEQER 537

Query: 1817 YNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
            +  T+ ARD G PPL S   V + VLD NDN P   +      +SEN P  S V  +  +
Sbjct: 538  FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597

Query: 1877 DADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
            DAD+G N  +T +I   N    F ++  +G++  N   DRE+   Y   +   D  + PR
Sbjct: 598  DADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655

Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT-----PLTVLNGPIL----A 1987
             +      + I + D NDN P          V+ + P+ T     PL+ + G ++    A
Sbjct: 656  SSTAK---VTINVMDVNDNSP----------VVISPPSNTSFKLVPLSAIPGSVVAEVFA 702

Query: 1988 LDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPP---ILELLLLA 2043
            +D D  + A + Y ++ G   GLF I+  TG +T+        E  +P    +  L++  
Sbjct: 703  VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL-------EEKPAPTDVGLHRLVVNI 755

Query: 2044 EDIGLLNSTAHLLITILDDND 2064
             D+G   S   L++  L  ND
Sbjct: 756  SDLGYPKSLHTLVLVFLYVND 776



 Score =  211 bits (538), Expect = 7e-54
 Identities = 210/761 (27%), Positives = 323/761 (42%), Gaps = 58/761 (7%)

Query: 792  PPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDREN---- 844
            P D +++ + A     G + +LVY +           ++S+TG+I TT   +DRE     
Sbjct: 44   PKDLNISHINAAT---GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAG 100

Query: 845  ---PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
                + +E     ++V+   D  R          + + + D NDN P F +      + E
Sbjct: 101  ASYAEENECFFELEVVILPNDFFR-------LIKIKIIVKDTNDNAPMFPSPVINISIPE 153

Query: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDF-LINSSSGV----VVTTTELDRE 956
                        A D D G NG+  Y +  G       ++ +  G     ++    LDRE
Sbjct: 154  NTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDRE 213

Query: 957  RIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
            +   Y +++   D GTP KSST+ L + V DVND  P F      V + E+ P    V+ 
Sbjct: 214  QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273

Query: 1017 LNCTDNDVGLNAELSYFITGGNV----DGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA 1072
            L+ TD D+G NAE+ Y I G  V       F++     ++     LDRE TA + + + A
Sbjct: 274  LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332

Query: 1073 IDNGPVGKRHTGTATVFVTVLDVNDNRP------IFLQSSYEASVPEDIPEGHSILQLKA 1126
             D    G      ATV + V DVNDN P      I    +    + E  P    I  +  
Sbjct: 333  SD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388

Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
            +D D    G+V    +      + +    N  L+     LD E        + A +    
Sbjct: 389  SDKDTDVNGKV-ICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447

Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
             +  +  V V +ED ND  P+F  Q    L + E    G  +  + ATD DSG    + Y
Sbjct: 448  SLNQTALVRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506

Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
            ++   A   F++D  TG++      D E +  ++  V+A D   P  Q   +V +T+L+E
Sbjct: 507  QLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565

Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
             D + +F++  ++  + ENL   + +  +     D         +          F +D 
Sbjct: 566  NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDP 622

Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRF--DFTSD 1423
             +GVI      DRE+   YT  V A DGG P   ST KV I V+D NDNSP      ++ 
Sbjct: 623  YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682

Query: 1424 SAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFV 1481
            S   +P     G  VA V A D D G N ++ +++ SGN  G F I  VT N ++ E   
Sbjct: 683  SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEE--- 739

Query: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
             +P   +   H ++ V  SD G P  K  H L +  L +ND
Sbjct: 740  -KPAPTDVGLHRLV-VNISDLGYP--KSLHTLVLVFLYVND 776



 Score =  202 bits (513), Expect = 6e-51
 Identities = 226/796 (28%), Positives = 337/796 (42%), Gaps = 94/796 (11%)

Query: 137 YSVR--IPENTPVGTPIFIVNATDPDLGAGGSV-----LYSFQPPSQFFAIDSARG-IVT 188
           Y++R  +PEN P+G     +N +  +   G S      L S    +    + S+ G I T
Sbjct: 28  YTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFT 87

Query: 189 VIRELDYETTQA-----------YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFI 237
               +D E   A           ++L V     D  R    L  + II+ D  D  P+F 
Sbjct: 88  TSNRIDREKLCAGASYAEENECFFELEVVILPNDFFR----LIKIKIIVKDTNDNAPMFP 143

Query: 238 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYIS------- 290
           +   + +I E++   +   I +A D D G      Y +++G   S+F LD +        
Sbjct: 144 SPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEGEKW 201

Query: 291 GVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             L +   LDRE       +++ +K   + D  TP  ++ T    + V D+NDN P F  
Sbjct: 202 PQLIVQQNLDREQ---KDTYVMKIK---VEDGGTPQKSS-TAILQVTVSDVNDNRPVFKE 254

Query: 351 SEYSVAITELAQVGFALPLFIQVVDKDENLGLNS----MFEVYLVGNNSHHFIISPTSVQ 406
            +  V I E A VG ++   IQ+   D ++G N+    +F   +       F ++ T+  
Sbjct: 255 GQVEVHIPENAPVGTSV---IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG- 310

Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANE--SVPDHVGYAKVKITLINENDNRP------ 458
                 I V   LD E    +   + A++  S P     A V I + + NDN P      
Sbjct: 311 -----LITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDLRY 362

Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PDRFSLDKDTG-LIM 516
           I S     + L E   V T +  +  +D D    G+V  F   + P       D   L+ 
Sbjct: 363 IISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE 422

Query: 517 LIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENE 574
             + LDYE  + F+  I+A D G      T  VR+ + D NDN P F +     ++ EN 
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482

Query: 575 PSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN 634
                L  + ATDEDS  N  I Y +       S+FD+      GV++ SR  D E+   
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL---GPNASFFDLD--RKTGVLTASRVFDREEQER 537

Query: 635 GLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLN 694
                TV A D G PPL S   V + V DENDN P F+   +   V EN+   +TV  + 
Sbjct: 538 --FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595

Query: 695 ATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVG 754
            TD D      +   +  L  +  F ++  SG I +    DRE +S Y   V+A DGG  
Sbjct: 596 VTDADAGE--NKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653

Query: 755 HNQKTGIATVNITLLDINDNHPTWKDAP--YYINLVEMTP-PDSDVTTVVAVDPDLGENG 811
               T   T+N+  +D+NDN P     P      LV ++  P S V  V AVD D G N 
Sbjct: 654 PRSSTAKVTINV--MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 812 TLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLK 869
            L Y+I   N    + ++  TG I         E P P +  L R +VV+++D G P   
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITL------EEKPAPTDVGLHR-LVVNISDLGYP--- 761

Query: 870 ATSSATVFVNLLDLND 885
             S  T+ +  L +ND
Sbjct: 762 -KSLHTLVLVFLYVND 776



 Score =  191 bits (485), Expect = 1e-47
 Identities = 190/665 (28%), Positives = 304/665 (45%), Gaps = 82/665 (12%)

Query: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
            I + + + D NDN P+F  P    ++ E+  + +     +ATD D+G   +  Y L +G+
Sbjct: 126  IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185

Query: 2446 SKFAINPTTG-------DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
            S F ++            + V  +LDRE+KD Y++    +D      + ++ ++  + + 
Sbjct: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG----GTPQKSSTAILQVT 241

Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA--- 2555
            V DVND RP F + Q    + EN P GTSVI + ATD D G N E+ Y        A   
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 2556 -FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP--- 2609
             F ++  +GL+T QR L   E     +TV+A+DG   P   T  + + V DVNDN P   
Sbjct: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNID 359

Query: 2610 --VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI-- 2665
                + P NGT+ ++ E+ P+ + +  +  +DKD  +NG V   F++    R+  F +  
Sbjct: 360  LRYIISPINGTV-YLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIE----REVPFHLKA 413

Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
            +     L++T+  LD E    +S  +VASD G+P   +T   ++V LED +DN P+F +P
Sbjct: 414  VYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-VRVKLEDENDNPPIFNQP 472

Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGC 2784
                     L+V E++ RG  +  ++ A D D G NA + Y +  G     F L +  G 
Sbjct: 473  VIE------LSVSENNRRGLYLTTIS-ATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523

Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
            L   R  DRE +  F F V A  N   TPP                 V V + D ND  P
Sbjct: 524  LTASRVFDREEQERFIFTVTARDNG--TPPLQSQAA-----------VIVTVLDENDNSP 570

Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQV 2904
            +FT   +   V+ +    S +  +   DAD G N  V  SIL         ND+++    
Sbjct: 571  KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL---------NDNDN---- 617

Query: 2905 FTMGSMDGILRTFDLFMAYSPGYFVVDIVARD--LAGHNDTAIIGIYILRDDQRVKIVIN 2962
            F +    G++++   F       +  D+ A D      + TA + I ++  +    +VI+
Sbjct: 618  FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677

Query: 2963 EIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRIL 3022
              P     F+   +  LS I G++V      F VD    +N    EL   +V+ +   + 
Sbjct: 678  --PPSNTSFK---LVPLSAIPGSVVAE---VFAVDVDTGMN---AELKYTIVSGNNKGLF 726

Query: 3023 DVDRV 3027
             +D V
Sbjct: 727  RIDPV 731



 Score =  181 bits (459), Expect = 1e-44
 Identities = 178/627 (28%), Positives = 279/627 (44%), Gaps = 56/627 (8%)

Query: 69  VSGEEASRFFAVEPDTGVVW----LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQ 121
           ++G+       VE   G  W    ++Q LDRE K  + ++  V D    Q   T  + + 
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241

Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-----QPPSQ 176
           V DVNDN P F      V IPEN PVGT +  ++ATD D+G+   + Y F         +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 177 FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD----M 232
            FA+++  G++TV R LD E T  +++TV A+D   T      A + I +TDV D    +
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVTINVTDVNDNPPNI 358

Query: 233 DPIFINLPYSTNIY--EHSPPGTTVRIITAIDQD---KGRPRGIGYTIVSGNTNSIFALD 287
           D  +I  P +  +Y  E  P  T + +IT  D+D    G+        V  +  +++   
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418

Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
           Y+   L  + LLD E        I+       +D   PS    T    + + D NDN P 
Sbjct: 419 YL---LETSSLLDYEGTKEFSFKIVA------SDSGKPS-LNQTALVRVKLEDENDNPPI 468

Query: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
           FN     ++++E  + G  L     +   DE+ G N+   VY +G N+  F      +  
Sbjct: 469 FNQPVIELSVSENNRRGLYL---TTISATDEDSGKNADI-VYQLGPNASFF-----DLDR 519

Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYN 466
           K  + +  +   D E  +R+ F + A ++  P     A V +T+++ENDN P F+   + 
Sbjct: 520 KTGV-LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQ 578

Query: 467 ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELI 526
             + EN+   ++V  +  TD DAG    V+    +D D F LD  +G+I      D E  
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQ 638

Query: 527 QRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSV---TQLV 581
             +T  + A DGG     +T +V INV+DVNDN P         + +    S    + + 
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698

Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
            + A D D+  N ++ Y+IVS +  G +    +     +     P D      GL  L V
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDV-----GLHRLVV 753

Query: 642 MAMDAGNP-PLNSTVPVTIEVFDENDN 667
              D G P  L++ V V + V D   N
Sbjct: 754 NISDLGYPKSLHTLVLVFLYVNDTAGN 780



 Score =  150 bits (379), Expect = 2e-35
 Identities = 145/500 (29%), Positives = 222/500 (44%), Gaps = 47/500 (9%)

Query: 42  ISEDTPVGSSVTQLLAQDMD-----NDPLVFGVSGEEAS-RFFAVEPDTGVVWLRQPLDR 95
           I E+ PVG+SV QL A D D         +FG     A+ R FA+   TG++ +++ LDR
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDR 320

Query: 96  ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
           E  +   V    SD      R  V I V DVNDN P    +        +V + E  PV 
Sbjct: 321 EETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVN 380

Query: 149 TPIFIVNATDPDLGAGGSVL--YSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
           T I ++  +D D    G V+     + P    A+   + ++     LDYE T+ +   + 
Sbjct: 381 TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIV 440

Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
           A+D  K   L+  A + + + D  D  PIF       ++ E++  G  +  I+A D+D G
Sbjct: 441 ASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499

Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
           +   I Y +  G   S F LD  +GVLT + + DRE       FI TV   +       S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREE---QERFIFTVTARDNGTPPLQS 554

Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV---VDKDENLGLN 383
            A V  T    V+D NDN+P+F  + +   ++E       LP +  V      D + G N
Sbjct: 555 QAAVIVT----VLDENDNSPKFTHNHFQFFVSE------NLPKYSTVGVITVTDADAGEN 604

Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVG 442
               + ++ N++ +F++ P S   K++      +  D E    Y FD+ A +   P    
Sbjct: 605 KAVTLSIL-NDNDNFVLDPYSGVIKSN------VSFDREQQSSYTFDVKATDGGQPPRSS 657

Query: 443 YAKVKITLINENDNRPIFSQPLYNIS---LYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
            AKV I +++ NDN P+   P  N S   +  +   G+ V  V A D D G   E+ Y  
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717

Query: 500 --SDDPDRFSLDKDTGLIML 517
              ++   F +D  TG I L
Sbjct: 718 VSGNNKGLFRIDPVTGNITL 737



 Score =  145 bits (365), Expect = 9e-34
 Identities = 157/555 (28%), Positives = 238/555 (42%), Gaps = 65/555 (11%)

Query: 2408 QEAVFEDVPVGTII--LTVTATDADSGNFALIEYSLGD--GESKFA-INPTTGDIYVLSS 2462
            +E + E+VP+G I   L ++  +A +G  A + Y L    G++    ++ +TG+I+  S+
Sbjct: 31   REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 2463 -LDREKKDHYILTALAKDNPGD------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
             +DREK       + A++N         +  N     +++ I V D ND  P F  P  +
Sbjct: 91   RIDREKL--CAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG---------LVT 2566
             S+ EN    +      ATD D G NG   Y L   G   F +D+            +V 
Sbjct: 149  ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQ 207

Query: 2567 TQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI-LHIREE 2625
                 +  + + + +   DGG P    T +L V V DVNDNRPVF     G + +HI E 
Sbjct: 208  QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVF---KEGQVEVHIPEN 264

Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
             P+ ++V +++ATD D G N  +RY F           F ++  +GLI   + LDRE  A
Sbjct: 265  APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324

Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
            ++ + ++ASD G   P      + V   D++DN P        SP    + + E  P  T
Sbjct: 325  IHKVTVLASD-GSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP--DGCLLVLRD--LDREREAIFSF 2801
             +  +T   D D   N  V  FI     E  FHL+   D   L+     LD E    FSF
Sbjct: 382  KIALIT-VSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437

Query: 2802 IVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKV 2861
             + AS +          P+L+  A      VRV LED ND PP F +      V+ + + 
Sbjct: 438  KIVASDS--------GKPSLNQTA-----LVRVKLEDENDNPPIFNQPVIELSVSENNRR 484

Query: 2862 GSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFM 2921
            G  L  + A D D G N+ + Y +     F             F +    G+L    +F 
Sbjct: 485  GLYLTTISATDEDSGKNADIVYQLGPNASF-------------FDLDRKTGVLTASRVFD 531

Query: 2922 AYSPGYFVVDIVARD 2936
                  F+  + ARD
Sbjct: 532  REEQERFIFTVTARD 546


>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
          Length = 1886

 Score =  285 bits (729), Expect = 5e-76
 Identities = 306/1078 (28%), Positives = 472/1078 (43%), Gaps = 138/1078 (12%)

Query: 443  YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-----ATDNDAGTFGEVSY 497
            Y +V+I + + NDN P F    Y  ++ E   VGT++ T       ATD D G  G++ Y
Sbjct: 130  YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189

Query: 498  FFS---DDP---DRFSLDKD-TGLIMLIARLDYELIQRFTLTIIARDGGGE-----ETTG 545
                  DDP   D F +    TG I+L  RL+YE   R+ + I A D          TT 
Sbjct: 190  VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249

Query: 546  RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV-----------------RLRATDE 588
             + ++VLD +D  P F     V   R+  P   Q                    ++A D+
Sbjct: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309

Query: 589  D---SPPNNQ--ITYSIVSASAFGSYFDISLYEGYGVISVSRPL--DYEQISNGLIYLTV 641
            D    PP+++  I YSI+  +         ++     +S+  P+  D+ Q  +    L +
Sbjct: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD----LVI 365

Query: 642  MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV---------LF 692
             A      PL +   + IE+ DEN+  P F+ P+Y   ++E+   GAT+         L 
Sbjct: 366  KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425

Query: 693  LNATDLDRSREYGQESIIYSLEGSTQFRINAR--SGEITTTSLLDRETKSEYILIVRAVD 750
            + A D D       E  ++  + ++ F +     +  +T    +DRE +  Y   + A D
Sbjct: 426  IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485

Query: 751  GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
            G     Q++    VNI ++D NDN PT+ +  Y + +     P   V  + AVD D G N
Sbjct: 486  GV----QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541

Query: 811  GTLVYSIQPPNKF-YSLNSTTGKIRT----------THAM-------------------- 839
            G + Y I    +  + +N TTG I            T+A+                    
Sbjct: 542  GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTL 601

Query: 840  ---LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPF 895
               LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP 
Sbjct: 602  GKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPR 652

Query: 896  VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
               V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+R
Sbjct: 653  NLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 708

Query: 956  ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
            E    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    ++
Sbjct: 709  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 768

Query: 1016 WLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILE 1071
             +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++E
Sbjct: 769  QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826

Query: 1072 AIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADE 1131
            A D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD 
Sbjct: 827  AFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884

Query: 1132 GEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
                  RV YR   +      + F +   +G ++     L+ E  +   L+V A++    
Sbjct: 885  PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEP 943

Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
             M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + Y
Sbjct: 944  VMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVY 998

Query: 1247 RILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFCS 1298
             I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P       
Sbjct: 999  SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1058

Query: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTST 1356
            VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR       
Sbjct: 1059 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1118

Query: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
            + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1119 EGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176



 Score =  265 bits (677), Expect = 6e-70
 Identities = 327/1308 (25%), Positives = 553/1308 (42%), Gaps = 185/1308 (14%)

Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
            ++  F+N+T       R LDR+  P    +I V+    N ++    Y  + I + D NDN
Sbjct: 91   KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143

Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
             P F   +Y A V E +P GT + T  +G   A D D      + Y +         +  
Sbjct: 144  SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 203

Query: 2010 FDINSS-TGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
            F+I    TG + +R  +  + +     I++    A+++     +T  L + +LD +D  P
Sbjct: 204  FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 2068 TFSPATLTVHLLENCP-----------------PGFSVLQVTATDEDSGLNGE-----LV 2105
             F P  L  +  +  P                 P      + A D+D  +        ++
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
            Y I  G  +     F +H  T  + +    ++R+  + + L + A      PL   A + 
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEP-VNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 382

Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
            I I D N+  P F  P     +LESA  G  I++         I A+D D+         
Sbjct: 383  IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED------- 435

Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTGS---VMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
                KD    L  N   +      TG    + +  P++RE   TY  +++  D   +   
Sbjct: 436  ---TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP 492

Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
              V++        V+D NDNTP F       Y   +     PG ++I + AVD D+G NG
Sbjct: 493  VIVNI-------QVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 542

Query: 2330 LVTYTLLD---------------LVPPGY-----------VQLEDS------SAGKVIAN 2357
             +TY +L                 + PG            VQ  D+      S G +   
Sbjct: 543  EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLG 602

Query: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV 2417
            + +D E        + ASD G P   +   V + + D+NDN P+FD    +     +   
Sbjct: 603  KALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 661

Query: 2418 GTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
               +  V ATD D+G    + YSLG+  + F I  + G IY    L+RE +D+Y L  +A
Sbjct: 662  NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVA 720

Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
             D     A + R +++ + I+VLD++D  P F+   ++  V EN PAGT+++ + A D D
Sbjct: 721  TDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776

Query: 2538 EGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF-------SLTVVATD--GG 2587
             G N  ++Y +  P V+ F  +   +G ++  R L  YE F       +  V A D  G 
Sbjct: 777  LGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGT 833

Query: 2588 EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNG 2646
             PP  G   + V V D+ND  PVF +     +  +  +    + +  VYA D D  GL  
Sbjct: 834  MPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPA 889

Query: 2647 A-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETM 2705
            + VRY             F ++  SG + T   L+ E   ++ L++VA D G+PV   + 
Sbjct: 890  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949

Query: 2706 QPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVY 2765
                + L       P F +      +Y+   V E + +GT+VG ++ A       N  + 
Sbjct: 950  TVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVISAAAI-----NQSIV 997

Query: 2766 YFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            Y I +GNEE  F +    G + V   LD E    +   V+A S             L + 
Sbjct: 998  YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA------NLRVP 1051

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
            +     +V + ++D N+ PP F K  Y  GV+ DA++ + +++V A D D GN     YS
Sbjct: 1052 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN-----YS 1106

Query: 2885 ILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD-----LAG 2939
            ++A   +R +    ++  + F + +  G+++T  LF      YF   ++A D     L+G
Sbjct: 1107 VMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1163

Query: 2940 HNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL-----SNITGA--IVNTDNV 2992
              D  +  +  L  D +V IV N  P  V    E+   +L       I GA  +V +   
Sbjct: 1164 KADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGA 1220

Query: 2993 QFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNY-----NV 3047
            + H D     ++ + +L ++ ++  TNR +D + + + +D     +   F+ Y      +
Sbjct: 1221 RRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRI 1280

Query: 3048 LDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVLMNW 3088
            L+++   +V    +  + +   + A++ LA ++ L    A+L VL+++
Sbjct: 1281 LEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSY 1328



 Score =  259 bits (662), Expect = 3e-68
 Identities = 298/1093 (27%), Positives = 472/1093 (43%), Gaps = 137/1093 (12%)

Query: 1620 VYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-----IQALDLDEGPNGTVTYAI 1674
            V + + D NDN+P F+   Y   ++E    + T++ T       A D+D+GPNG + Y I
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191

Query: 1675 VAG----NIVNTFRIDRHM-GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
                      +TF I   + G I   K L+YE    RY +I+ A D+   L+ R T+TTT
Sbjct: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTT 250

Query: 1730 VLVNVNDINDNVPTF-------------PRDYEG--PFEVTEGQPGPRVWT----FLAHD 1770
            + V+V D +D  P F             P  Y+   P   T  +  P + T     +  D
Sbjct: 251  LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310

Query: 1771 RDSGPNGQ---VEYSIMDGDPLGE---FVISPVEGVLRVRKDVELDRETIAFYNLTICAR 1824
            R+  P      + YSI+ G P      F + P    L + + V  +R+    ++L I A 
Sbjct: 311  RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV--NRDFHQKFDLVIKAE 368

Query: 1825 DRGMPPLSSTMLVGIRVLDINDNDP----------VLLNLPMNITISENSPVSSFVAHVL 1874
                 PL +   + I +LD N+  P          +L + P+  TIS++  ++S    ++
Sbjct: 369  QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS-PLRIV 427

Query: 1875 ASDADSGCNARLTFNITAGNRERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNP 1932
            A D D         ++   +    F +  T  T  +T+ +P+DRE    Y  +I+  D  
Sbjct: 428  ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 486

Query: 1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ 1992
                +   +  ++ I + D NDN P F + +Y   V  +   G  +  L     A+DAD+
Sbjct: 487  ----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT----AVDADE 538

Query: 1993 DIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGV--------------------------- 2025
                 +TY++L    G F IN +TG++T+  GV                           
Sbjct: 539  GSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGI 598

Query: 2026 -----IIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSP-ATLTVHLL 2079
                  +DRE+    IL ++  ++      STA + I + D NDN P F P     + ++
Sbjct: 599  LTLGKALDRESTDRYIL-IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657

Query: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQES 2139
            E     F V QV ATD D+G+NG++ Y +        L  + +         ++RE ++ 
Sbjct: 658  EEEANAF-VGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713

Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
            Y L VVATD    P   T  + I + DI+D+ P F N   TV V E+   GT I  I A 
Sbjct: 714  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 773

Query: 2200 DHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
            D DL   + Y I             P  +  FA++  TG + +   ++ E     E +++
Sbjct: 774  DVDLGANVSYRIRS-----------PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 822

Query: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
             +  A D+   ++    A +TV V D+ND  P F       Y   +   A  GT +  V 
Sbjct: 823  FLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSK---RIYKGMVAPDAVKGTPITTVY 878

Query: 2320 AVDPD-KGL-NGLVTYTLLDL---VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRA 2374
            A D D  GL    V Y + D+    P    ++E+ S G+VI    ++ E        V A
Sbjct: 879  AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS-GRVITRVNLNEEPTTIFKLVVVA 937

Query: 2375 SDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQ-EAVFEDVPVGTIILTVTATDADSGN 2433
             D+G P  ++   V + ++   +  P F Q  Y+   V E    GT++  ++A   +   
Sbjct: 938  FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS- 995

Query: 2434 FALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR--- 2488
               I YS+  G+ E  F IN  TG IYV   LD E +  Y+L   A      +A+ R   
Sbjct: 996  ---IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1052

Query: 2489 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL 2548
            + N+ +V I++ D N+  P F K  +   V E+    TSV+ + ATD+D G    + Y L
Sbjct: 1053 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112

Query: 2549 EGP----GVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVI 2602
              P    G E F V+  +GL+ T     +  +  F   V+ATD     L G   +LV V+
Sbjct: 1113 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1172

Query: 2603 DVNDNRPVFVRPP 2615
            +  D + +    P
Sbjct: 1173 NQLDMQVIVSNVP 1185



 Score =  249 bits (635), Expect = 4e-65
 Identities = 294/1095 (26%), Positives = 457/1095 (41%), Gaps = 148/1095 (13%)

Query: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187

Query: 168  LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
             Y  Q     P S   F       G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247

Query: 219  LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307

Query: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366

Query: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422

Query: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477

Query: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLI-------MLIAR------------------- 520
            D G+ GE++Y         F ++K TGLI       M++ R                   
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERST 596

Query: 521  --------LDYELIQRFTLTIIARDGGGEET-TGRVRINVLDVNDNVPTFQKDAYVGALR 571
                    LD E   R+ L I A DG  + T T  V I V DVNDN P F          
Sbjct: 597  GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 656

Query: 572  ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEG-YGVISVSRPL-DY 629
              E +   + +++ATD D+  N Q+ YS+     F + F I+     Y  + ++R + DY
Sbjct: 657  VEEEANAFVGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713

Query: 630  EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
             +       L V+A D    P +ST+ + I+V D +DN P F+   Y V V EN+ AG T
Sbjct: 714  YE-------LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766

Query: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRET----KSEYILI 745
            +L + A D+D          I S E    F ++  +GE++    LD E     ++    +
Sbjct: 767  ILQIEAKDVDLGANVSYR--IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824

Query: 746  VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
            V A D  +      GIATV + + D+ND  P +    Y   +       + +TTV A D 
Sbjct: 825  VEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 882

Query: 806  D-LGENGTLV-YSIQP-----PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
            D  G   + V Y +       P   + +   +G++ T      R N +     + + +VV
Sbjct: 883  DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT------RVNLNEEPTTIFKLVVV 936

Query: 859  SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
            +  D G P +  +SSATV + +L   +     Q       V E    G  +  + A    
Sbjct: 937  AFDD-GEPVM--SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA---- 989

Query: 919  EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR-------VVASDAG 971
              +N  + Y +  G     F IN+ +GV+     LD E    Y LR       VV ++  
Sbjct: 990  AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1049

Query: 972  TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
             P+KS+T+ + I + D N+  P F    Y   VSED      V+ +  TD D G  + ++
Sbjct: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109

Query: 1032 YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML-----ILEAIDNGPVGKRHTGTA 1086
            Y +    +      G    VV T  GL +     + +       + I     GK  +G A
Sbjct: 1110 YRL----IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1165

Query: 1087 TVFVTVLDVNDNRPI 1101
             V V+V++  D + I
Sbjct: 1166 DVLVSVVNQLDMQVI 1180



 Score =  244 bits (623), Expect = 1e-63
 Identities = 315/1195 (26%), Positives = 502/1195 (42%), Gaps = 179/1195 (14%)

Query: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94

Query: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149

Query: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207

Query: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263

Query: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323

Query: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383

Query: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443

Query: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498

Query: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555

Query: 719  FRINARSGEITTT----------------------------------SLLDRETKSEYIL 744
            F IN  +G IT                                      LDRE+   YIL
Sbjct: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYIL 615

Query: 745  IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAV 803
            I+ A DG       T  ATVNI + D+NDN P +    P  +++VE    ++ V  V A 
Sbjct: 616  IITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKAT 671

Query: 804  DPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
            DPD G NG + YS+   N  + + S  G I T    L+RE  D +E      +VV  TD 
Sbjct: 672  DPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDG 723

Query: 864  GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
               P  +T   T+ + +LD++DN P F N  +   V E +PAG +I Q+ A D+D G N 
Sbjct: 724  AVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN- 780

Query: 924  LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTS 979
             VSYR+     +  F ++  +G +     LD E   + +  +     A D         +
Sbjct: 781  -VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 839

Query: 980  TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGG 1037
            T+T+ V D+ND  P F   +Y   V+ D  +   +  +   D D  GL A  + Y +   
Sbjct: 840  TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 899

Query: 1038 NVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVL 1093
                    F V      V T V L+ E T  + L++ A D+G PV    + +ATV + VL
Sbjct: 900  QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVL 956

Query: 1094 DVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
               +  P F Q  Y    V E   +G  +  + A   ++     + Y I+ GN  + F I
Sbjct: 957  HPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGI 1011

Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEA 1205
            +   G++     PLD E  +S+VL V+A + ++       P +S+  +V + ++D N+  
Sbjct: 1012 NNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070

Query: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDE 1260
            PVF ++ Y   G+ E A + TSV+ V+ATD+D+G+  ++ YR++      G EG F ++ 
Sbjct: 1071 PVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVET 1128

Query: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
             TGLI T        ++ +   V ATD       G   V ++++N+LD  V  SN
Sbjct: 1129 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183



 Score =  239 bits (610), Expect = 3e-62
 Identities = 304/1175 (25%), Positives = 497/1175 (42%), Gaps = 183/1175 (15%)

Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT-----VKAWDPDAGSNGQVVFS 1457
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245

Query: 1508 KKDHILQVTILDINDNPPVIE-----------SPFGYNVSV-----NENVGGGTAVVQVR 1551
                 L V +LD +D  P+              P  Y  ++      E +        ++
Sbjct: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305

Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL-EPVNRDFHQKFDLV 364

Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482

Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 483  AFD-------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535

Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE---------------------- 1808
             D G NG++ Y I+ G   G+F+I+   G++ +   VE                      
Sbjct: 536  ADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER 594

Query: 1809 ----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVL-LNLPMN 1857
                      LDRE+   Y L I A D G P  +ST  V I V D+NDN PV    LP N
Sbjct: 595  STGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 653

Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRE 1917
            +++ E    ++FV  V A+D D+G N ++ +++  GN    F I +   I T  + L+RE
Sbjct: 654  LSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNRE 709

Query: 1918 RIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP 1977
                Y+L +   D   +PR +      L I + D +DN P+FT STY   V EN PAGT 
Sbjct: 710  VRDYYELVVVATDGAVHPRHSTL---TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT- 765

Query: 1978 LTVLNGPILALDA-DQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSPP 2035
                   IL ++A D D+ A V+Y++   +    F ++  TG +++     +D EAF   
Sbjct: 766  ------TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPDQ 817

Query: 2036 ILELLLLAEDIGLLNS----TAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
               +  L E   +  +     A + + + D ND  P FS       +  +   G  +  V
Sbjct: 818  EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877

Query: 2092 TATDED-SGLNGELV-YRIE----AGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
             A D D  GL    V YR++          F +   +G + +    ++ E    ++L VV
Sbjct: 878  YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV-ITRVNLNEEPTTIFKLVVV 936

Query: 2146 ATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP 2205
            A D G   +S +A V IL+    +         +   V E A  GT++  I+A    +N 
Sbjct: 937  AFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA--AINQ 994

Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNAS 2265
             + Y IV             N+ED F +N  TG + V  P++ E   +Y   L V  ++ 
Sbjct: 995  SIVYSIVS-----------GNEEDTFGINNITGVIYVNGPLDYETRTSY--VLRVQADSL 1041

Query: 2266 DLPERSVSVPN----AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAV 2321
            ++   ++ VP+    AK+ + + D N++ P F+     +Y+  + E A   T+++ V A 
Sbjct: 1042 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK---KFYIGGVSEDARMFTSVLRVKAT 1098

Query: 2322 DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEV--------HWLNFTVR 2373
            D D G   ++ Y L  ++PP    +++   G V+   T   +           +  F V 
Sbjct: 1099 DKDTGNYSVMAYRL--IIPP----IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152

Query: 2374 ASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ--PSYQEAVFED------------VPVGT 2419
            A+D+     + +  V + +V+  D   I     P+  E   ED            +P   
Sbjct: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAK 1212

Query: 2420 IILTVTATDADSGNFALIEYSLGDGESKFAINPTT 2454
            +++           F+L +Y+  D  + +AI+P T
Sbjct: 1213 VVVESIGARRHGDAFSLEDYTKCD-LTVYAIDPQT 1246



 Score =  230 bits (587), Expect = 2e-59
 Identities = 283/1081 (26%), Positives = 460/1081 (42%), Gaps = 173/1081 (16%)

Query: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
            V + V D NDN PTF  +  Y    E+T    G  ++T  + D      D GPNGQ+EY 
Sbjct: 133  VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190

Query: 1783 IM--DGDPLGEFVIS---PVEGVLRVRKDVELDRETIAFYNLTICARDRGM---PPLSST 1834
            I     DP           + G + +RK +  + +T  F  + I A DR        ++T
Sbjct: 191  IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF--VIIQANDRAQNLNERRTTT 248

Query: 1835 MLVGIRVLDINDNDPVLLN------------------LPMNITISENSPVSSFVAHVLAS 1876
              + + VLD +D  P+ L                   +P   T  E +P+      + A 
Sbjct: 249  TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAI 307

Query: 1877 DADSGCNAR-----LTFNITAGNRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISV 1928
            D D           + ++I  G  E   R F ++  T  +++  P++R+   ++ L I  
Sbjct: 308  DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367

Query: 1929 KDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPI 1985
            + +  +P  A   +  L I + DEN+  P FT  +YQ  ++E++P G  ++    L  P+
Sbjct: 368  EQDNGHPLPA---FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424

Query: 1986 LALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV-RSGVI--------IDREAFSPPI 2036
              +  D+DI      +L      LF +N  T V TV ++G+         +DRE      
Sbjct: 425  RIVALDKDIEDTKDPEL-----HLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE--EQQT 476

Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
                + A D    +    + I ++D NDN PTF   +  V++  +  PG SV+Q+TA D 
Sbjct: 477  YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536

Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVG---------------------------- 2128
            D G NGE+ Y I  GAQ  F+I+  TG+I +                             
Sbjct: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERST 596

Query: 2129 -----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI--QTV 2181
                    +DRE  + Y L + A+D G    + TA V I++ D+ND+ P F +P   + +
Sbjct: 597  GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 654

Query: 2182 SVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
            SV+E  E    +  + A D D  +N ++ Y +              N  + F +  N GS
Sbjct: 655  SVVEE-EANAFVGQVKATDPDAGINGQVHYSL-------------GNFNNLFRITSN-GS 699

Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
            +     +NRE+   YE+ +   D A   P  S       L + VLD++DN+P F     T
Sbjct: 700  IYTAVKLNREVRDYYELVVVATDGAVH-PRHS----TLTLAIKVLDIDDNSPVFTNSTYT 754

Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
              +E   E    GTT++ + A D D G N  V+Y +       +  L   + G++   R+
Sbjct: 755  VLVE---ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT-GELSLLRS 808

Query: 2360 VDYE----EVHWLNFTVRASD--NGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE 2413
            +DYE    +   + F V A D     PP  A + V ++  D+ND  P+F +  Y+  V  
Sbjct: 809  LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAP 866

Query: 2414 DVPVGTIILTVTATDADSGNF--ALIEYSLGDGE-----SKFAINPTTGDIYVLSSLDRE 2466
            D   GT I TV A DAD      + + Y + D +     S F +   +G +    +L+ E
Sbjct: 867  DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 926

Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
                + L  +A D+   V S    +S  V I VL   +       P+F+   Y   P   
Sbjct: 927  PTTIFKLVVVAFDDGEPVMS----SSATVKILVLHPGEI------PRFTQEEYRPPPVSE 976

Query: 2527 SVI--TMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ-----SY---- 2574
                 TM+        N  + YS+  G   + F ++  +G++    PL      SY    
Sbjct: 977  LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1036

Query: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
            +  SL VV  +   P    T  + +E+ D N++ PVF +     I  + E+  + ++V  
Sbjct: 1037 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK--KFYIGGVSEDARMFTSVLR 1094

Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS 2694
            V ATDKD G    + Y  +        E F+++  +GLI+TA       ++ +   ++A+
Sbjct: 1095 VKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1154

Query: 2695 D 2695
            D
Sbjct: 1155 D 1155



 Score =  224 bits (570), Expect = 1e-57
 Identities = 271/1049 (25%), Positives = 447/1049 (42%), Gaps = 127/1049 (12%)

Query: 983  IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-----LNCTDNDVGLNAELSYFITGG 1037
            I V D ND +PTF    Y  +V+E  P    +          TD D G N ++ Y I   
Sbjct: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194

Query: 1038 NVDGKFSVGYRDAVVRT--VV---GLDRETTAAYMLILEAIDNGP-VGKRHTGTATVFVT 1091
              D   +  +   ++ T  +V    L+ E    Y +I++A D    + +R T T T+ V 
Sbjct: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254

Query: 1092 VLDVNDNRPIFLQS------------SYEASVPE-DIPEGHSIL----QLKATDADEG-- 1132
            VLD +D  P+FL              +Y+A++PE   PE  + +     ++A D D    
Sbjct: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314

Query: 1133 ---EFGRVWYRILHG---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
               +   + Y IL G   ++   F +H     L     P++R+ +    L+++A   +  
Sbjct: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL-LEPVNRDFHQKFDLVIKAEQDNGH 373

Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIG---------TSVIVVQATDRD 1237
            P+ +   + + + D N+++P FT   Y    L E+A +G         TS + + A D+D
Sbjct: 374  PLPAFAGLHIEILDENNQSPYFTMPSYQGYIL-ESAPVGATISDSLNLTSPLRIVALDKD 432

Query: 1238 SGDGGLVNYRI-LSGAEGKFEIDES--TGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ 1294
              D       + L+     F + ++  T  +  +  +D E + +Y  +++A D       
Sbjct: 433  IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP 492

Query: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITY---- 1348
               ++ +   N  D    F   SY+  +  ++  G  ++++ A   D  +  +ITY    
Sbjct: 493  VIVNIQVMDAN--DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550

Query: 1349 --------------------------RFNAYTSTQAKALFKIDAITGVITVQGLVDREKG 1382
                                      R  A T   A      +  TG++T+   +DRE  
Sbjct: 551  GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610

Query: 1383 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVK 1442
            D Y L + A DG P   ST  V I V D NDN+P FD      +S+ E+      V  VK
Sbjct: 611  DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 669

Query: 1443 AWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDR 1502
            A DPDAG NGQV +SL  GN    F I     S G ++ A  L+RE  D+Y L VVA+D 
Sbjct: 670  ATDPDAGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRDYYELVVVATDG 723

Query: 1503 GTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV 1562
               PR     L + +LDI+DN PV  +   Y V V EN+  GT ++Q+ A D D+G N  
Sbjct: 724  AVHPRHSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN-- 780

Query: 1563 LSYYITEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1617
            +SY I        F +   +GE++        A PD+E  S   LV   +  GT      
Sbjct: 781  VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAFDIYGTMPPGIA 839

Query: 1618 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG--PNGTVTYAI 1674
            T V V + D ND  P+F +  Y+ ++   PD +  T + T+ A D D    P   V Y +
Sbjct: 840  T-VTVIVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPPGLPASRVRYRV 896

Query: 1675 VAGNI---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVL 1731
                     + F ++   G +     L+ E +     ++V   D  P++S    S+ TV 
Sbjct: 897  DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS----SSATVK 952

Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLG 1790
            + V    + +P F ++   P  V+E    G  V    A    +  N  + YSI+ G+   
Sbjct: 953  ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007

Query: 1791 EFVISPVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSSTMLVGIRVLDIN 1845
             F I+ + GV+ V   ++ +  T     +   +L +   +  +P  S+T  V I + D N
Sbjct: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067

Query: 1846 DNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFIN 1902
            ++ PV         +SE++ + + V  V A+D D+G  + + + +        +  F + 
Sbjct: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127

Query: 1903 ATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
              TG++         R   +K  +   D+
Sbjct: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDD 1156



 Score =  191 bits (484), Expect = 1e-47
 Identities = 217/830 (26%), Positives = 353/830 (42%), Gaps = 126/830 (15%)

Query: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447

Query: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505

Query: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565

Query: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLST----------------------------- 218
            T+   ++    + Y LTV A D       ST                             
Sbjct: 566  TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPD 625

Query: 219  ---LANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT 274
                A + I++TDV D  P+F   LP + ++ E       V  + A D D G    + Y+
Sbjct: 626  GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYS 684

Query: 275  IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
            +  GN N++F +     + T    L+RE   Y    ++   G        P  +T+T   
Sbjct: 685  L--GNFNNLFRITSNGSIYTA-VKLNREVRDYYELVVVATDGAV-----HPRHSTLTLA- 735

Query: 335  NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
             I V+DI+DN+P F +S Y+V + E    G  +   +Q+  KD +LG N  + +      
Sbjct: 736  -IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI---LQIEAKDVDLGANVSYRI-RSPEV 790

Query: 395  SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---------FDLFANESVPDHVGYAK 445
             H F + P + +      + +   LDYE     +         FD++   ++P   G A 
Sbjct: 791  KHFFALHPFTGE------LSLLRSLDYEAFPDQEASITFLVEAFDIYG--TMPP--GIAT 840

Query: 446  VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF--GEVSYFFSD-- 501
            V + + + ND  P+FS+ +Y   +  +   GT + TV A D D        V Y   D  
Sbjct: 841  VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900

Query: 502  ---DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVN-DN 557
                   F +++D+G ++    L+ E    F L ++A D G    +    + +L ++   
Sbjct: 901  FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960

Query: 558  VPTFQKDAYVGALRENEPSVTQLV---RLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
            +P F ++ Y        P V++L     +      +  N  I YSIVS +   ++    +
Sbjct: 961  IPRFTQEEY------RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF---GI 1011

Query: 615  YEGYGVISVSRPLDYEQISNGLI-----YLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
                GVI V+ PLDYE  ++ ++      L V+  +   P  ++T  V IE+ DEN++PP
Sbjct: 1012 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1071

Query: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSL------EGSTQFRIN 722
             F K  Y   V E+     +VL + ATD D     G  S++ Y L      EG   F + 
Sbjct: 1072 VFQKKFYIGGVSEDARMFTSVLRVKATDKDT----GNYSVMAYRLIIPPIKEGKEGFVVE 1127

Query: 723  ARSGEITTTSLLDRETKSEYILIVRAVDG-GVGHNQKTGIATVNITLLDI 771
              +G I T  L     +S +   V A D  G G + K  +    +  LD+
Sbjct: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1177



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99

Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150

Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210

Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388

Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442

Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487

Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547

Query: 2885 IL 2886
            IL
Sbjct: 548  IL 549


>gi|16933565 protocadherin 21 precursor [Homo sapiens]
          Length = 859

 Score =  281 bits (719), Expect = 8e-75
 Identities = 235/720 (32%), Positives = 349/720 (48%), Gaps = 62/720 (8%)

Query: 12  AWLLVLISGCWGQVNRLPFFTNHFFDT----------YLLISEDTPVGSSVTQLLAQDMD 61
           A  L L+  C  Q N    F  HFFD              + EDTPVGS V  L   D +
Sbjct: 8   ALALGLLRLCLAQAN----FAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63

Query: 62  NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
            DP+ + +S + ++R  F+V+P  G + L + LDRE + E     S+SD   ++  KV I
Sbjct: 64  GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVI 123

Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
            V D ND AP F  +PY   +PE+ P G+ IF V+A D D G+GGSV Y  Q     FA+
Sbjct: 124 LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAV 183

Query: 181 DSARGIVTVI--RELDYETTQAYQLTVNATD-----QDKTRPLSTLANLAIIITDVQDMD 233
           D   G++ +     LDYE ++ + +TV A D            S    + + + DVQDM 
Sbjct: 184 DRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243

Query: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVL 293
           P+F+  PY   +YE + PG+ V  + A+D D+G+P  I Y++V+GN +  F ++  SG +
Sbjct: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAI 302

Query: 294 TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF----- 348
           ++         L    + L V+ TE++   +P+ A  T    I ++D+N++ P F     
Sbjct: 303 SIT---QSPAQLQREVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPPTFYGESG 358

Query: 349 NSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
             + + +++ E    G  L  L I V D D+  G N+ F + LVG     F + P +V  
Sbjct: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQ--GANAKFNLQLVGPRG-IFRVVPQTVLN 415

Query: 408 KADIRIRV--AIPLDYETVDRYDFDLFANE-SVPDHV-GYAKVKITLINENDNRPIFSQP 463
           +A + I V  +  +D+E      F L A E + P+     A V I L++ NDN P F   
Sbjct: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475

Query: 464 LYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIML--IAR 520
            Y   + EN   G+SV+ V A D D G +GEV Y  +    D F +   TGLI     A 
Sbjct: 476 YYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWAS 535

Query: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
           LD E   R+   + A D  G+ +   V I +LDVND+ P F K      +    P     
Sbjct: 536 LDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP----- 590

Query: 581 VRLRATDEDS-PPNNQITYSIVSASAFGSYFDISLYEGYGVISVS-RPLD-YEQISNG-- 635
           V++ A DED+  PNN + YSI  A    + FDI+ + G   +  S R LD    I+ G  
Sbjct: 591 VKIEAIDEDAEEPNNLVDYSITHAEP-ANVFDINSHTGEIWLKNSIRSLDALHNITPGRD 649

Query: 636 -LIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK---PAYFVSVVENIMAGATVL 691
            L  L V A D G+P  ++T  + I++ D      T S+    A+ +   +N M    VL
Sbjct: 650 CLWSLEVQAKDRGSPSFSTTALLKIDITDAE----TLSRSPMAAFLIQTKDNPMKAVGVL 705



 Score =  173 bits (439), Expect = 2e-42
 Identities = 168/586 (28%), Positives = 254/586 (43%), Gaps = 49/586 (8%)

Query: 454  NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FSLDK 510
            N N  +FS P       E+  VG+ V T+  TD +      +SY  S DP     FS+D 
Sbjct: 36   NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDP 85

Query: 511  DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570
              G I L+  LD E        II+   G      +V I V D ND  P F ++ YV  +
Sbjct: 86   TFGNITLVEELDREREDEIE-AIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALV 144

Query: 571  RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630
             E+ P+ + + ++ A D D+     +TY + +     S F +  + G   +     LDYE
Sbjct: 145  PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH---SPFAVDRHSGVLRLQAGATLDYE 201

Query: 631  QISNGLIYLTVMAMDAG------NPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
            +      Y+TV+A D G      +   ++T  VT+ V D  D  P F    Y+  V E+ 
Sbjct: 202  RSRTH--YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDT 259

Query: 685  MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTT---SLLDRETK 739
            + G+ VL + A D DR +      I+YSL       F IN  SG I+ T   + L RE  
Sbjct: 260  LPGSEVLKVVAMDGDRGKP---NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVY 316

Query: 740  SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT----PPDS 795
              ++ +      G    Q T    V I ++D+N++ PT+       N  E++    PP  
Sbjct: 317  ELHVQVTEMSPAGSPAAQAT--VPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG 374

Query: 796  DVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
            ++   + +   D D G N      +  P   + +   T  +      +  EN    + E 
Sbjct: 375  EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQT-VLNEAQVTIIVENSAAIDFEK 433

Query: 853  MRKIVVSVTDCG-RPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
             + +   +       P K +S+A V + LLD NDN P F +L +VA + E  P G S+  
Sbjct: 434  SKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVA 493

Query: 912  VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT--TELDRERIAEYQLRVVASD 969
            V A+D D G  G V Y    G     FLI+ S+G++ T     LD E  A Y   V A D
Sbjct: 494  VTAVDPDTGPWGEVKY-STYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED 552

Query: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
                 K S + + I +LDVND  P F  +V   ++    P +   +
Sbjct: 553  --MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAI 596



 Score =  169 bits (428), Expect = 4e-41
 Identities = 190/664 (28%), Positives = 290/664 (43%), Gaps = 68/664 (10%)

Query: 1003 SVSEDVPREFRVVWLNCTDNDVGLNAELSYFIT-GGNVDGKFSVGYRDAVVRTVVGLDRE 1061
            S+ ED P    V  LN TD +      +SY I+   +    FSV      +  V  LDRE
Sbjct: 43   SLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99

Query: 1062 TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
                   I+   D       +     V + V D ND  P F+Q  Y A VPEDIP G  I
Sbjct: 100  REDEIEAIISISDG-----LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154

Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEA 1180
             ++ A D D G  G V Y +   N  + F +   +G+L ++    LD ER+ +H + V A
Sbjct: 155  FKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVA 212

Query: 1181 YN-----HDLGPMRS-SVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234
             +     H    + S +  V V VED+ D APVF    Y      +T   G+ V+ V A 
Sbjct: 213  KDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAM 271

Query: 1235 DRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAP---P 1291
            D D G    + Y +++G +G FEI+E++G I          +  Y ++V  T+ +P   P
Sbjct: 272  DGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP 331

Query: 1292 FNQGFCSVYITLLNELDEAVQFSNAS-----YEAAILENLALGTEIVRVQAYSIDNLNQ- 1345
              Q    V I +++  +    F   S     +E ++ E+   G EI+R    ++++ +Q 
Sbjct: 332  AAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG-EILRGLKITVNDSDQG 390

Query: 1346 ITYRFNAYTSTQAKALFKI--------DAITGVITVQGLVDREKGDFYTLTVVADDGG-- 1395
               +FN       + +F++          +T ++     +D EK    T  ++A +    
Sbjct: 391  ANAKFNLQL-VGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449

Query: 1396 PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVV 1455
             K  ST  V I +LD NDN P+FD +      IPE+ P G  V  V A DPD G  G+V 
Sbjct: 450  EKFSSTADVVIQLLDTNDNVPKFD-SLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508

Query: 1456 FSLASGNIAGAFEIVTTNDSIGEVFVA--RPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
            +S   G  A  F I   + S G ++      LD E    Y   V A D       K  + 
Sbjct: 509  YS-TYGTGADLFLI---HPSTGLIYTQPWASLDAEATARYNFYVKAEDM----EGKYSVA 560

Query: 1514 QV--TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDI-GINSVLSYYITEG 1570
            +V  T+LD+ND+PP     FG +V     V G    V++ A D D    N+++ Y IT  
Sbjct: 561  EVFITLLDVNDHPP----QFGKSVQKKTMVLG--TPVKIEAIDEDAEEPNNLVDYSITHA 614

Query: 1571 NKDMAFRMDRISGEIATRPAPPDRE--------RQSFYHLVATVEDEGTPTLSATTHVYV 1622
                 F ++  +GEI  + +    +        R   + L    +D G+P+ S T  + +
Sbjct: 615  EPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKI 674

Query: 1623 TIVD 1626
             I D
Sbjct: 675  DITD 678



 Score =  167 bits (424), Expect = 1e-40
 Identities = 164/599 (27%), Positives = 269/599 (44%), Gaps = 54/599 (9%)

Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
            + F +D   G IT  +ELD E        I++ +D   +++ +      V++ V D ND 
Sbjct: 79   SVFSVDPTFGNITLVEELDRE-REDEIEAIISISDGLNLVAEK------VVILVTDANDE 131

Query: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
             P F ++        +   G  ++   A DRD+G  G V Y + +      F +    GV
Sbjct: 132  APRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH--SPFAVDRHSGV 189

Query: 1801 LRVRKDVELDRETIAFYNLTICARDRGMP------PLSSTMLVGIRVLDINDNDPVLLNL 1854
            LR++    LD E    + +T+ A+D G          S+T  V + V D+ D  PV +  
Sbjct: 190  LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT 249

Query: 1855 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPL 1914
            P    + E++   S V  V+A D D G   R+ +++  GN + AF IN T+G +++ +  
Sbjct: 250  PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSP 308

Query: 1915 DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLF-----TKSTYQAEVM 1969
             + +   Y+L + V +       A +    + I + D N++ P F      ++ ++  + 
Sbjct: 309  AQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMN 368

Query: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029
            E+ P G  L  L   I   D+DQ   A    QL+G + G+F +   T +   +  +I++ 
Sbjct: 369  EHPPQGEILRGLK--ITVNDSDQGANAKFNLQLVGPR-GIFRVVPQTVLNEAQVTIIVEN 425

Query: 2030 EAF----SPPILELLLLAEDIGL---LNSTAHLLITILDDNDNRPTFSPATLTVHLLENC 2082
             A        +L   LLA ++      +STA ++I +LD NDN P F        + EN 
Sbjct: 426  SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENA 485

Query: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGN-ATIDREEQESYR 2141
            P G SV+ VTA D D+G  GE+ Y       D FLIH  TG+I     A++D E    Y 
Sbjct: 486  PGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYN 545

Query: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201
              V A D           +T+L  D+ND  P+F   +Q  +++     GT +  I AID 
Sbjct: 546  FYVKAEDMEGKYSVAEVFITLL--DVNDHPPQFGKSVQKKTMV----LGTPV-KIEAIDE 598

Query: 2202 DL---NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257
            D    N  ++Y I                 + F +N +TG + +K+ + R L A + +T
Sbjct: 599  DAEEPNNLVDYSITH-----------AEPANVFDINSHTGEIWLKNSI-RSLDALHNIT 645



 Score =  161 bits (407), Expect = 1e-38
 Identities = 178/634 (28%), Positives = 281/634 (44%), Gaps = 64/634 (10%)

Query: 569  ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
            +L E+ P  + +  L  TD +  P   I+Y I    +  S F +     +G I++   LD
Sbjct: 43   SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVD--PTFGNITLVEELD 97

Query: 629  YEQISNGLIYLTVMAMDAGNPPLNSTVP-VTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
             E+         + A+ + +  LN     V I V D ND  P F +  Y   V E+I AG
Sbjct: 98   REREDE------IEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG 151

Query: 688  ATVLFLNATDLDRSREYGQESIIYSLEG-STQFRINARSG--EITTTSLLDRE-TKSEYI 743
            + +  ++A D D        S+ Y L+   + F ++  SG   +   + LD E +++ YI
Sbjct: 152  SIIFKVHAVDRDTG---SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 208

Query: 744  LIVRAVDGGVGHNQK---TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800
             +V    GG  H      +   TV + + D+ D  P +   PYY  + E T P S+V  V
Sbjct: 209  TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268

Query: 801  VAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTH--AMLDRENPDPHEAELMRKIV 857
            VA+D D G+   ++YS+   N   + +N T+G I  T   A L RE  + H        V
Sbjct: 269  VAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQ------V 322

Query: 858  VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF------QNLPFVAEVLEGIPAGVSI-- 909
              ++  G P  +AT   T+   ++DLN++ PTF      QN  F   + E  P G  +  
Sbjct: 323  TEMSPAGSPAAQATVPVTI--RIVDLNNHPPTFYGESGPQNR-FELSMNEHPPQGEILRG 379

Query: 910  YQVVAIDLDEGLNGLVSYRM--PVGMPRM--DFLINSSSGVVVT--TTELDRERIAEYQL 963
             ++   D D+G N   + ++  P G+ R+    ++N +   ++   +  +D E+      
Sbjct: 380  LKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTF 439

Query: 964  RVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
            +++A +  TP K SST+ + I +LD ND  P F    Y   + E+ P    VV +   D 
Sbjct: 440  KLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDP 499

Query: 1023 DVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV--VGLDRETTAAYMLILEAIDNGPVGK 1080
            D G   E+ Y   G   D  F +     ++ T     LD E TA Y   ++A D     +
Sbjct: 500  DTGPWGEVKYSTYGTGAD-LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM----E 554

Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGR-VWY 1139
                 A VF+T+LDVND+ P F +S  + ++    P     ++++A D D  E    V Y
Sbjct: 555  GKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDY 609

Query: 1140 RILHGNHGNNFRI--HVSNGLLMRGPRPLDRERN 1171
             I H    N F I  H     L    R LD   N
Sbjct: 610  SITHAEPANVFDINSHTGEIWLKNSIRSLDALHN 643



 Score =  160 bits (405), Expect = 2e-38
 Identities = 147/524 (28%), Positives = 234/524 (44%), Gaps = 59/524 (11%)

Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
            V + + D ND  P F Q  Y   V ED+P G+II  V A D D+G+   + Y L +  S 
Sbjct: 121  VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP 180

Query: 2448 FAINPTTGDIYVLS--SLDREKKDHYILTALAKDNPGDV--ASNRRENSVQVVIQVLDVN 2503
            FA++  +G + + +  +LD E+   + +T +AKD  G +  A      +  V + V DV 
Sbjct: 181  FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240

Query: 2504 DCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG 2563
            D  P F    +   VYE+   G+ V+ ++A D D G    + YSL      AF ++  SG
Sbjct: 241  DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG 300

Query: 2564 LVT-TQRPLQ-SYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRPVFVR---PP 2615
             ++ TQ P Q   E + L V  T+    G P    T  + + ++D+N++ P F     P 
Sbjct: 301  AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360

Query: 2616 NGTILHIREEIPLRSNV--YEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP----- 2668
            N   L + E  P    +   ++   D D+G N       +   G      F + P     
Sbjct: 361  NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG-----IFRVVPQTVLN 415

Query: 2669 ---ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
               ++ +++ +  +D E   V +  L+A ++  P  + +   + + L D +DN P F   
Sbjct: 416  EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF--- 472

Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2785
                  Y +  +PE++P G+ V  VT AVD D GP   V Y    G     F + P   L
Sbjct: 473  ---DSLYYVARIPENAPGGSSVVAVT-AVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGL 527

Query: 2786 LVLR---DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842
            +  +    LD E  A ++F VKA                D+    ++ EV + L D+ND 
Sbjct: 528  IYTQPWASLDAEATARYNFYVKAE---------------DMEGKYSVAEVFITLLDVNDH 572

Query: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN-NSLVFYSI 2885
            PP+F K+     V     V    +++ A+D D    N+LV YSI
Sbjct: 573  PPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 611



 Score =  159 bits (402), Expect = 4e-38
 Identities = 168/589 (28%), Positives = 259/589 (43%), Gaps = 56/589 (9%)

Query: 1346 ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVY 1405
            I+Y  +   ST  +++F +D   G IT+   +DRE+ D     +   DG   V    KV 
Sbjct: 67   ISYHISFDPST--RSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAE--KVV 122

Query: 1406 ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAG 1465
            I V D ND +PRF         +PED P G  +  V A D D GS G V + L   N+  
Sbjct: 123  ILVTDANDEAPRF-IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHS 179

Query: 1466 AFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT------ILD 1519
             F  V  +  +  +     LD E    + + VVA D G      D +   T      + D
Sbjct: 180  PFA-VDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVED 238

Query: 1520 INDNPPV-IESPF-GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFR 1577
            + D  PV + +P+ GY   V E+   G+ V++V A D D G  + + Y +  GN D AF 
Sbjct: 239  VQDMAPVFVGTPYYGY---VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFE 294

Query: 1578 MDRISGEIATRPAPPDRERQSF--YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF- 1634
            ++  SG I+   +P   +R+ +  +  V  +   G+P   AT  V + IVD N++ P F 
Sbjct: 295  INETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFY 354

Query: 1635 ----QQPHYEVLLDEGP---DTLNTSLITIQALDLDEGPNGTVT---------YAIVAGN 1678
                 Q  +E+ ++E P   + L    IT+   D D+G N             + +V   
Sbjct: 355  GESGPQNRFELSMNEHPPQGEILRGLKITVN--DSDQGANAKFNLQLVGPRGIFRVVPQT 412

Query: 1679 IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDIN 1738
            ++N  ++     ++  +  +D+E S      ++      P    + +ST  V++ + D N
Sbjct: 413  VLNEAQVTI---IVENSAAIDFEKSKVLTFKLLAVEVNTP---EKFSSTADVVIQLLDTN 466

Query: 1739 DNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPV 1797
            DNVP F   Y     + E  P G  V    A D D+GP G+V+YS   G     F+I P 
Sbjct: 467  DNVPKFDSLYY-VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPS 524

Query: 1798 EGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMN 1857
             G++  +    LD E  A YN  + A D  M    S   V I +LD+ND+ P        
Sbjct: 525  TGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSVQK 582

Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTG 1906
             T+   +PV       +  DA+   N  + ++IT       F IN+ TG
Sbjct: 583  KTMVLGTPVK---IEAIDEDAEEP-NNLVDYSITHAEPANVFDINSHTG 627



 Score =  158 bits (400), Expect = 8e-38
 Identities = 178/696 (25%), Positives = 285/696 (40%), Gaps = 65/696 (9%)

Query: 1185 LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLV 1244
            LG +R  +    +     D     T    +   L E   +G+ V  +  TD +   G  +
Sbjct: 11   LGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE---GDPI 67

Query: 1245 NYRIL--SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
            +Y I         F +D + G I  V  LD E +      +S +D     N     V I 
Sbjct: 68   SYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG---LNLVAEKVVIL 124

Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKA 1360
            + +  DEA +F    Y A + E++  G+ I +V A   D  +   +TY      S     
Sbjct: 125  VTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP---- 180

Query: 1361 LFKIDAITGVITVQG--LVDREKGDFYTLTVVADDGGPKV-------DSTVKVYITVLDE 1411
             F +D  +GV+ +Q    +D E+   + +TVVA DGG ++        +T  V + V D 
Sbjct: 181  -FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDV 239

Query: 1412 NDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
             D +P F  T      + ED   G  V  V A D D G   ++++SL +GN  GAFEI  
Sbjct: 240  QDMAPVFVGTPYYGY-VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINE 297

Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
            T+ +I        L RE  + ++     S  G+P  +    + + I+D+N++PP      
Sbjct: 298  TSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES 357

Query: 1532 G----YNVSVNENVGGGTAV--VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE- 1584
            G    + +S+NE+   G  +  +++   D D G N+  +  +             +  E 
Sbjct: 358  GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417

Query: 1585 ----IATRPAPPDRERQSFYHLVATVEDEGTPT-LSATTHVYVTIVDENDNAPMFQQPHY 1639
                I    A  D E+           +  TP   S+T  V + ++D NDN P F   +Y
Sbjct: 418  QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477

Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK--E 1697
               + E      +S++ + A+D D GP G V Y+   G   + F I    G+I       
Sbjct: 478  VARIPENAPG-GSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWAS 535

Query: 1698 LDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEG 1757
            LD E +  RY   V A D          S   V + + D+ND+ P F +  +    V   
Sbjct: 536  LDAEAT-ARYNFYVKAEDM-----EGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVL-- 587

Query: 1758 QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
              G  V      +    PN  V+YSI   +P   F I+   G + ++  +   R   A +
Sbjct: 588  --GTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI---RSLDALH 642

Query: 1818 NLT----------ICARDRGMPPLSSTMLVGIRVLD 1843
            N+T          + A+DRG P  S+T L+ I + D
Sbjct: 643  NITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678



 Score =  154 bits (388), Expect = 2e-36
 Identities = 180/717 (25%), Positives = 298/717 (41%), Gaps = 87/717 (12%)

Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATI----D 2133
            L E+ P G  V  +  TD +      + Y I      R +  +       GN T+    D
Sbjct: 44   LPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDP---TFGNITLVEELD 97

Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVI 2193
            RE ++     +  +D   +       V IL+ D ND  P F+       V E    G++I
Sbjct: 98   REREDEIEAIISISDGLNLVAEK---VVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154

Query: 2194 ANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELV 2251
              + A+D D             +       + N    FAV+ ++G + +++   ++ E  
Sbjct: 155  FKVHAVDRDTG-----------SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERS 203

Query: 2252 ATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGAT 2310
             T+ +T+   D    L    V       +TVNV DV D  P F   G  YY   + E   
Sbjct: 204  RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF--VGTPYY-GYVYEDTL 260

Query: 2311 PGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF 2370
            PG+ ++ V A+D D+G    + Y+L++     +   E S A  +  +      EV+ L+ 
Sbjct: 261  PGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHV 320

Query: 2371 TV-RASDNGSPPRAAEIPVYLEIVDINDNNPIF-----DQPSYQEAVFEDVPVGTII--L 2422
             V   S  GSP   A +PV + IVD+N++ P F      Q  ++ ++ E  P G I+  L
Sbjct: 321  QVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGL 380

Query: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTT----GDIYVL----SSLDREKKD--HYI 2472
             +T  D+D G  A     L      F + P T      + ++    +++D EK     + 
Sbjct: 381  KITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFK 440

Query: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532
            L A+  + P   +S     +  VVIQ+LD ND  P+F    +   + EN P G+SV+ + 
Sbjct: 441  LLAVEVNTPEKFSS-----TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVT 495

Query: 2533 ATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQ----RPLQSYEKFSLTVVATDGGE 2588
            A D D GP GE+ YS  G G + F +   +GL+ TQ       ++  +++  V A D   
Sbjct: 496  AVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--M 553

Query: 2589 PPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGA 2647
               +    + + ++DVND+ P F +        ++++  +     ++ A D+D E  N  
Sbjct: 554  EGKYSVAEVFITLLDVNDHPPQFGK-------SVQKKTMVLGTPVKIEAIDEDAEEPNNL 606

Query: 2648 VRYSFLKT-------AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
            V YS             +   E ++ + I  L      +      ++SL + A D G P 
Sbjct: 607  VDYSITHAEPANVFDINSHTGEIWLKNSIRSL-DALHNITPGRDCLWSLEVQAKDRGSP- 664

Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR---GTLVGNVTGAV 2754
             + T   L++   DI D E L       SP    L   + +P    G L G +   V
Sbjct: 665  SFSTTALLKI---DITDAETL-----SRSPMAAFLIQTKDNPMKAVGVLAGTMATVV 713



 Score =  143 bits (361), Expect = 2e-33
 Identities = 147/513 (28%), Positives = 228/513 (44%), Gaps = 62/513 (12%)

Query: 2396 NDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTG 2455
            N N  +F  P       ED PVG+ + T+  TD +    +          S F+++PT G
Sbjct: 36   NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFG 88

Query: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
            +I ++  LDRE++D         D    VA        +VVI V D ND  P+F +  + 
Sbjct: 89   NITLVEELDREREDEIEAIISISDGLNLVAE-------KVVILVTDANDEAPRFIQEPYV 141

Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ-SY 2574
              V E+ PAG+ +  + A D+D G  G +TY L+      F VD  SG++  Q      Y
Sbjct: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH-SPFAVDRHSGVLRLQAGATLDY 200

Query: 2575 EKFS---LTVVATDGG------EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
            E+     +TVVA DGG      +     TT + V V DV D  PVFV  P     ++ E+
Sbjct: 201  ERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG--YVYED 258

Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ---RLDRE 2682
                S V +V A D D G    + YS +    N +   F I+  SG I   Q   +L RE
Sbjct: 259  TLPGSEVLKVVAMDGDRGKPNRILYSLV----NGNDGAFEINETSGAISITQSPAQLQRE 314

Query: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHS 2741
               ++  +   S  G P    T+ P+ + + D++++ P F    +  PQ +  L++ EH 
Sbjct: 315  VYELHVQVTEMSPAGSPAAQATV-PVTIRIVDLNNHPPTFYG--ESGPQNRFELSMNEHP 371

Query: 2742 PRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGCL------LVLRD---L 2791
            P+G ++  +   V D+D+G NA   + +        F + P   L      +++ +   +
Sbjct: 372  PQGEILRGLKITVNDSDQGANA--KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI 429

Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
            D E+  + +F + A    +   P   S T D+V  L          D ND  P+F    Y
Sbjct: 430  DFEKSKVLTFKLLAVEVNT---PEKFSSTADVVIQLL---------DTNDNVPKFDSLYY 477

Query: 2852 TAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
             A +  +A  GS ++ V A+D D G    V YS
Sbjct: 478  VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS 510



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 74/276 (26%), Positives = 116/276 (42%), Gaps = 32/276 (11%)

Query: 2616 NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQT 2675
            N  +  + E+ P+ S+VY +  TD +      + Y        R    F +DP  G I  
Sbjct: 38   NMALFSLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRS--VFSVDPTFGNITL 92

Query: 2676 AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLL 2735
             + LDRE +     I+  SD    V  + +    + + D +D  P F++ P       + 
Sbjct: 93   VEELDREREDEIEAIISISDGLNLVAEKVV----ILVTDANDEAPRFIQEP------YVA 142

Query: 2736 TVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----D 2790
             VPE  P G+++  V  AVD D G    V YF+   N    F +     +L L+     D
Sbjct: 143  LVPEDIPAGSIIFKVH-AVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLD 199

Query: 2791 LDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850
             +R R    + + K    R            D+V   T   V V +ED+ D  P F    
Sbjct: 200  YERSRTHYITVVAKDGGGRLHGA--------DVVFSATTT-VTVNVEDVQDMAPVFVGTP 250

Query: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
            Y   V  D   GSE+++V+A+D D G  + + YS++
Sbjct: 251  YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLV 286



 Score = 59.3 bits (142), Expect = 6e-08
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 20/157 (12%)

Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLD 2792
            L ++PE +P G+ V  + G    D   + I Y+     +    F + P  G + ++ +LD
Sbjct: 41   LFSLPEDTPVGSHVYTLNGT---DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELD 97

Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
            RERE     I+  S              L+LVA+    +V +++ D ND+ PRF +  Y 
Sbjct: 98   REREDEIEAIISISDG------------LNLVAE----KVVILVTDANDEAPRFIQEPYV 141

Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIH 2889
            A V  D   GS + +V A+D D G+   V Y +  +H
Sbjct: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH 178


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  265 bits (678), Expect = 4e-70
 Identities = 215/701 (30%), Positives = 323/701 (46%), Gaps = 62/701 (8%)

Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE 1791
            + V DINDN P F               G      LA DRD+GPNG   Y +  G    E
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 1792 FVISPVEGVLRVRKDVE-----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
                     L+V +D E           LDRE    Y+LTI  +D G PP +S+ L+ + 
Sbjct: 216  LF------GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269

Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL--TFNITAGNRERA 1898
            VLD NDN P          +SENSP+   V  V A+D+D G NA +  TF+       R 
Sbjct: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329

Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP- 1957
              ++  TG++TV  P+DRE +   + ++  KD   NP+ AR     +++ + D NDN P 
Sbjct: 330  LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQ---VVVTVKDMNDNAPT 386

Query: 1958 -------LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
                   L T     A + E+    T + ++       D D+   A VT  + G      
Sbjct: 387  IEIRGIGLVTHQDGMANISEDVAEETAVALVQ----VSDRDEGENAAVTCVVAGDVPFQL 442

Query: 2011 DINSSTGVVTVRSGVI-----IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
               S TG  + +   +     +D E      +E++ +      L+ST  L + ++D NDN
Sbjct: 443  RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502

Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA--GAQDRFLIHLVTG 2123
             P F+ +   V   EN  PG  + ++TA+D DSG N ELVY +E    A+  F I   TG
Sbjct: 503  APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
             I+V   ++DRE++ESY L VVA DRG+  L GTA V + + D ND+ P+F+      SV
Sbjct: 563  EIQV-KTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621

Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
            +E+    + +  +T ID D     +  +   V +D+ D         F +   TG+++  
Sbjct: 622  MENMPALSPVGMVTVIDGDKGENAQVQL--SVEQDNGD---------FVIQNGTGTILSS 670

Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
               +RE  +TY   L  +D    +P RS  V    +T+NVLD NDN P       T +  
Sbjct: 671  LSFDREQQSTYTFQLKAVDGG--VPPRSAYV---GVTINVLDENDNAPYITAPSNTSH-- 723

Query: 2304 RILEGATP-GTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
            ++L   T  G T+  VAA D D G+N  + Y++    P G  Q+  S +G +   + ++ 
Sbjct: 724  KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI-GSHSGAITLEKEIER 782

Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
                     V+ SD G PPR     V+L + +   N  + +
Sbjct: 783  RHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823



 Score =  261 bits (667), Expect = 8e-69
 Identities = 226/779 (29%), Positives = 347/779 (44%), Gaps = 72/779 (9%)

Query: 247 EHSPPGTTVRIITAIDQDKGRPR---------GIGYTIVSGNTNSIFALDYISGVLTLNG 297
           E  PP T +  + A   D G P          G  Y  V G T  IF  +     +   G
Sbjct: 66  EEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETS---IDREG 119

Query: 298 LLDRENPLYSHGFILT--VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV 355
           L + +N L     IL   V  T+L  + +P          I V DINDN P F S   ++
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPR----LLEGQIEVQDINDNTPNFASPVITL 175

Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
           AI E   +G   P+ +   D+D      + +E+         F +     Q +   ++ V
Sbjct: 176 AIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIV 234

Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
              LD E  D YD  +   +   P     A +++T+++ NDN P F +P Y   L EN  
Sbjct: 235 MGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSP 294

Query: 475 VGTSVLTVLATDNDAGTFGEVSYFFSDDPD----RFSLDKDTGLIMLIARLDYELIQRFT 530
           +G SV+ V A D+D G   E+ Y F   P+       LD++TGLI +   +D E +    
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR 354

Query: 531 LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQ--------KDAYVGALRENEPSVTQL 580
            +++A+D G    + R  V + V D+NDN PT +            +  + E+    T +
Sbjct: 355 FSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAV 414

Query: 581 VRLRATDEDSPPNNQIT--------YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
             ++ +D D   N  +T        + +  AS  GS      +     +  + PLDYE++
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYF-----LQTTTPLDYEKV 469

Query: 633 SNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
            +  I   ++A+D+GNPPL+ST  + ++V D NDN P F++    V+  EN   G  +  
Sbjct: 470 KDYTI--EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527

Query: 693 LNATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
           + A+D D         ++YSLE        F I+  +GEI   + LDRE +  Y L V A
Sbjct: 528 ITASDADSG---SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584

Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
            D G    Q  G ATV + +LD NDN P +  + Y  +++E  P  S V  V  +D D G
Sbjct: 585 ADRGSPSLQ--GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642

Query: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
           EN  +  S++  N  + + + TG I ++    DRE    +  +L         D G PP 
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSS-LSFDREQQSTYTFQL------KAVDGGVPPR 695

Query: 869 KATSSATVFVNLLDLNDNDPTFQNLPFVAEVL--EGIPAGVSIYQVVAIDLDEGLNGLVS 926
            A    T  +N+LD NDN P        +  L       G ++ QV A D D G+N  + 
Sbjct: 696 SAYVGVT--INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753

Query: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV 985
           Y +  G P   F I S SG +    E++R     ++L V  SD G P +  T+ + ++V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  256 bits (653), Expect = 3e-67
 Identities = 211/682 (30%), Positives = 321/682 (47%), Gaps = 51/682 (7%)

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
            Q+ + DINDN P   SP    +++ EN   G+      A+DRD G N V SY +  G + 
Sbjct: 155  QIEVQDINDNTPNFASPV-ITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEA 213

Query: 1574 MA-FRMDRISGEIATRP-----APPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDE 1627
               F +     +   +P        DRER   Y L   V+D G+P  +++  + VT++D 
Sbjct: 214  QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273

Query: 1628 NDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI-VAGNIVNTF-RI 1685
            NDNAP F++P YE  L E    +  S+I ++A D D+G N  + Y    A  +V    R+
Sbjct: 274  NDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 1686 DRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
            DR+ G+IT    +D E +S  R++++       P      ++   V+V V D+NDN PT 
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTI 387

Query: 1745 P-------RDYEGPFEVTEGQPGPRVWTFL-AHDRDSGPN--------GQVEYSIMDGDP 1788
                       +G   ++E          +   DRD G N        G V + +     
Sbjct: 388  EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447

Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
             G    S  +    ++    LD E +  Y + I A D G PPLSST  + ++V+D+NDN 
Sbjct: 448  TG----SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503

Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF-INATTGI 1907
            PV       +   EN+     +A + ASDADSG NA L +++      +  F I+  TG 
Sbjct: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563

Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
            + V   LDRE+   Y+L +   D   +P +  +    +L+ + D NDN P F  S Y   
Sbjct: 564  IQVKTSLDREQRESYELKVVAADR-GSPSL--QGTATVLVNVLDCNDNDPKFMLSGYNFS 620

Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
            VMEN PA +P+    G +  +D D+   A V    +   +G F I + TG  T+ S +  
Sbjct: 621  VMENMPALSPV----GMVTVIDGDKGENAQVQLS-VEQDNGDFVIQNGTG--TILSSLSF 673

Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH--LLENCPPG 2085
            DRE  S    +L  +   +   ++   + I +LD+NDN P  +  + T H  L      G
Sbjct: 674  DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733

Query: 2086 FSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTV 2144
             +V QV A D DSG+N EL+Y I  G     F I   +G I +    I+R     +RL V
Sbjct: 734  ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERRHHGLHRLVV 792

Query: 2145 VATDRGTVPLSGTAIVTILIDD 2166
              +DRG  P  GTA+V + +++
Sbjct: 793  KVSDRGKPPRYGTALVHLYVNE 814



 Score =  253 bits (646), Expect = 2e-66
 Identities = 213/701 (30%), Positives = 322/701 (45%), Gaps = 52/701 (7%)

Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
            + V+DIND  P F     + L + E   IG+   +  A+DRD+G  G+ +Y + +G E +
Sbjct: 156  IEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214

Query: 1256 F--------EIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
                     + +E    +I +  LD E   SY + +   D   P       + +T+L+  
Sbjct: 215  ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274

Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKID 1365
            D A +F   SYEA + EN  +G  +++V+A   D     +I Y F+       + L ++D
Sbjct: 275  DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV-VRRLLRLD 333

Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTS-- 1422
              TG+ITVQG VDRE       +V+A D G    S   +V +TV D NDN+P  +     
Sbjct: 334  RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393

Query: 1423 -----DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG---NIAGAFEIVTTND 1474
                 D   +I ED      VA V+  D D G N  V   +A      +  A E  T +D
Sbjct: 394  LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE--TGSD 451

Query: 1475 SIGEVFV--ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
            S  + F+    PLD E++  Y +++VA D G PP    + L+V ++D+NDN PV      
Sbjct: 452  SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511

Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-EGNKDMAFRMDRISGEIATRPAP 1591
              V+  EN   G  + ++ A+D D G N+ L Y +  E      F +   +GEI  + + 
Sbjct: 512  -EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570

Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
             DRE++  Y L     D G+P+L  T  V V ++D NDN P F    Y   + E    L+
Sbjct: 571  -DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629

Query: 1652 -TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
               ++T+  +D D+G N  V  ++   N    F I    G I ++   D E     YT  
Sbjct: 630  PVGMVTV--IDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDRE-QQSTYTFQ 684

Query: 1711 VTATDQ-CPILSHRLTSTTTVLVNVNDINDNVP--TFPRDYEGPFEVTEGQPGPRVWTFL 1767
            + A D   P  S    +   V +NV D NDN P  T P +        + + G  V    
Sbjct: 685  LKAVDGGVPPRS----AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA 740

Query: 1768 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
            A D DSG N ++ YSI  G+P G F I    G + + K++E  R     + L +   DRG
Sbjct: 741  AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE--RRHHGLHRLVVKVSDRG 798

Query: 1828 MPPLSSTMLVGIRVLDINDNDPVL-------LNLPMNITIS 1861
             PP   T LV + V +   N  +L       L+ P++I I+
Sbjct: 799  KPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIA 839



 Score =  252 bits (644), Expect = 4e-66
 Identities = 235/801 (29%), Positives = 345/801 (43%), Gaps = 80/801 (9%)

Query: 927  YRMPVGMPRMDFLINSSSGVVVTT-TELDRERIAEYQLRVVASDAGTPTKSSTSTLT--- 982
            Y++ VG P +   ++  +G + TT T +DRE + E Q ++         + S + L    
Sbjct: 90   YKLEVGAPYLR--VDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147

Query: 983  --------IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
                    I V D+ND TP F   V  +++ E+            +D D G N   SY +
Sbjct: 148  SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 207

Query: 1035 TGGNVDGKFSVGYRDAVVRT-------VVG-LDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
              G  + +   G + A  +        V+G LDRE   +Y L ++  D G   +    +A
Sbjct: 208  QAGP-EAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPR--ASSA 264

Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNH 1146
             + VTVLD NDN P F + SYEA + E+ P GHS++Q+KA D+D+G    + Y       
Sbjct: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324

Query: 1147 --GNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
                  R+  + GL+ ++GP  +DRE  S+    V A +    P  +  +V+V V+D+ND
Sbjct: 325  VVRRLLRLDRNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382

Query: 1204 EAPVF-------TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKF 1256
             AP            Q     + E     T+V +VQ +DRD G+   V   +      + 
Sbjct: 383  NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442

Query: 1257 EIDESTG-------LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE 1309
                 TG        + T   LDYE    Y + + A D   P      S+ + +++  D 
Sbjct: 443  RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502

Query: 1310 AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
            A  F+ +  E A  EN   G  I  + A   D+ +     ++      AK LF I   TG
Sbjct: 503  APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562

Query: 1370 VITVQGLVDREKGDFYTLTVV-ADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
             I V+  +DRE+ + Y L VV AD G P +  T  V + VLD NDN P+F   S    S+
Sbjct: 563  EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNFSV 621

Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
             E+ P    V  V   D D G N QV  S+   N  G F I    +  G +  +   DRE
Sbjct: 622  MENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVI---QNGTGTILSSLSFDRE 676

Query: 1489 ELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS-VNENVGGGTAV 1547
            +   Y  Q+ A D G PPR     + + +LD NDN P I +P   +   +      G  V
Sbjct: 677  QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736

Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
             QV A D D G+N+ L Y I  GN    F++   SG I T     +R     + LV  V 
Sbjct: 737  SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795

Query: 1608 DEGTPTL--SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-- 1663
            D G P    +A  H+YV       N  +  +   E LL    DT          LD+D  
Sbjct: 796  DRGKPPRYGTALVHLYV-------NETLANRTLLETLLGHSLDT---------PLDIDIA 839

Query: 1664 -------EGPNGTVTYAIVAG 1677
                       G + + +VAG
Sbjct: 840  GDPEYERSKQRGNILFGVVAG 860



 Score =  230 bits (587), Expect = 2e-59
 Identities = 194/691 (28%), Positives = 305/691 (44%), Gaps = 35/691 (5%)

Query: 530  TLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
            ++T + ++G      G++ +   D+NDN P F       A+ EN    +      A+D D
Sbjct: 139  SITDLVQNGSPRLLEGQIEVQ--DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 590  SPPNNQITYSIVSASAFGSYFDISLYEGYGV----ISVSRPLDYEQISNGLIYLTVMAMD 645
            + PN   +Y + +       F + + E        + V   LD E+  +    LT+   D
Sbjct: 197  AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQD 254

Query: 646  AGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG 705
             G+PP  S+  + + V D NDN P F +P+Y   + EN   G +V+ + A D D+     
Sbjct: 255  GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314

Query: 706  QESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT 763
             E   +      +   R++  +G IT    +DRE  S     V A D G   N K+  A 
Sbjct: 315  IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT--NPKSARAQ 372

Query: 764  VNITLLDINDNHPTWKDAPYYI--------NLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
            V +T+ D+NDN PT +     +        N+ E    ++ V  V   D D GEN  +  
Sbjct: 373  VVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC 432

Query: 816  SIQPPNKFYSLN-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
             +     F     S TG        L    P  +E      I +   D G PPL +T+S 
Sbjct: 433  VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL 492

Query: 875  TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGM 933
             V V  +D+NDN P F          E    G  I ++ A D D G N  + Y + P   
Sbjct: 493  KVQV--VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550

Query: 934  PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETP 993
             +  F I+  +G +   T LDRE+   Y+L+VVA+D G+P+   T+T+ ++VLD ND  P
Sbjct: 551  AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610

Query: 994  TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVR 1053
             F  + YN SV E++P    V  +   D D G NA++   +   N  G F +      + 
Sbjct: 611  KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTIL 668

Query: 1054 TVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFL---QSSYEA 1109
            + +  DRE  + Y   L+A+D G P    + G   V + VLD NDN P       +S++ 
Sbjct: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---VTINVLDENDNAPYITAPSNTSHKL 725

Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
              P+    G ++ Q+ A D D G    + Y I  GN    F+I   +G +    + ++R 
Sbjct: 726  LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERR 783

Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
             +  H L+V+  +    P   +  V +YV +
Sbjct: 784  HHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814



 Score =  228 bits (581), Expect = 8e-59
 Identities = 211/707 (29%), Positives = 329/707 (46%), Gaps = 66/707 (9%)

Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTD 2221
            I + DIND+ P F +P+ T+++ E+   G++     A D D  P       G+ + +   
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPN------GVASYEL-- 207

Query: 2222 RLVPNQEDAFAVNI------NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
            +  P  ++ F + +          ++V   ++RE   +Y++T+ V D  S  P R+ S  
Sbjct: 208  QAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS--PPRASS-- 263

Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
             A L V VLD NDN P+F+      Y   + E +  G ++I V A D D+G N  + YT 
Sbjct: 264  -ALLRVTVLDTNDNAPKFER---PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF 319

Query: 2336 LDL--VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
                 V    ++L D + G +     VD E++  L F+V A D G+ P++A   V + + 
Sbjct: 320  HQAPEVVRRLLRL-DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378

Query: 2394 DINDNNPIFD-----QPSYQEA---VFEDVPVGTIILTVTATDADSG-NFALIEYSLGDG 2444
            D+NDN P  +       ++Q+    + EDV   T +  V  +D D G N A+     GD 
Sbjct: 379  DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV 438

Query: 2445 ESKFAINPTTGD-------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVI 2497
              +      TG        +   + LD EK   Y +  +A D+     S+   NS++V  
Sbjct: 439  PFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST--NSLKV-- 494

Query: 2498 QVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEA- 2555
            QV+DVND  P F++     +  EN   G  +  + A+D D G N EL YSLE  P  +  
Sbjct: 495  QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554

Query: 2556 FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVR 2613
            F +  ++G +  +  L  +  E + L VVA D G P L GT  +LV V+D NDN P F+ 
Sbjct: 555  FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614

Query: 2614 PPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
              +G    + E +P  S V  V   D D+G N  V+ S  +  G+     F+I   +G I
Sbjct: 615  --SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTI 667

Query: 2674 QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ 2733
             ++   DRE Q+ Y+  L A D G P P      + + + D +DN P    P   S  ++
Sbjct: 668  LSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTS--HK 724

Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLD 2792
            LLT    +  G  V  V  A D D G NA + Y IA GN    F +    G + + ++++
Sbjct: 725  LLT--PQTRLGETVSQVA-AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781

Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
            R    +   +VK S      PPR  +  + L  + TL   R +LE +
Sbjct: 782  RRHHGLHRLVVKVSDRGK--PPRYGTALVHLYVNETLAN-RTLLETL 825



 Score =  226 bits (576), Expect = 3e-58
 Identities = 194/664 (29%), Positives = 301/664 (45%), Gaps = 52/664 (7%)

Query: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ--PPSQ- 176
           I+V D+NDN P F +   ++ IPENT +G+   I  A+D D G  G   Y  Q  P +Q 
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 177 FFAIDSA------RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQ 230
            F +  A      +  + V+  LD E   +Y LT+   D   + P ++ A L + + D  
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD-GGSPPRASSALLRVTVLDTN 274

Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDY 288
           D  P F    Y   + E+SP G +V  + A D D+G    I YT          +  LD 
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334

Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
            +G++T+ G +DRE+       + T++ + L  DR  +  +      + V D+NDNAP  
Sbjct: 335 NTGLITVQGPVDRED-------LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387

Query: 349 --------NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHF-I 399
                      +    I+E      A+ L +QV D+DE  G N+     + G+       
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVAL-VQVSDRDE--GENAAVTCVVAGDVPFQLRQ 444

Query: 400 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRP 458
            S T    K    ++   PLDYE V  Y  ++ A +S  P       +K+ +++ NDN P
Sbjct: 445 ASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504

Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP---DRFSLDKDTGLI 515
           +F+Q +  ++  EN   G  +  + A+D D+G+  E+ Y    +P     F++  +TG I
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564

Query: 516 MLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
            +   LD E  + + L ++A D G    + T  V +NVLD NDN P F    Y  ++ EN
Sbjct: 565 QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMEN 624

Query: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
            P+++ +  +   D D   N Q+  S+   +      D  +  G G I  S   D EQ S
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQS 679

Query: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA--YFVSVVENIMAGATVL 691
                L   A+D G PP ++ V VTI V DENDN P  + P+      +      G TV 
Sbjct: 680 TYTFQL--KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737

Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRA 748
            + A D D         +IYS+ G      F+I + SG IT    ++R     + L+V+ 
Sbjct: 738 QVAAEDFDSG---VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794

Query: 749 VDGG 752
            D G
Sbjct: 795 SDRG 798



 Score =  213 bits (543), Expect = 2e-54
 Identities = 190/636 (29%), Positives = 287/636 (45%), Gaps = 66/636 (10%)

Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---- 2336
            + V D+NDNTP F    IT     I E    G+      A D D G NG+ +Y L     
Sbjct: 156  IEVQDINDNTPNFASPVITL---AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212

Query: 2337 --DLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
              +L      + ++    ++I    +D E     + T++  D GSPPRA+   + + ++D
Sbjct: 213  AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272

Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG----ESKFAI 2450
             NDN P F++PSY+  + E+ P+G  ++ V A D+D G  A IEY+             +
Sbjct: 273  TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF- 2509
            +  TG I V   +DRE       + LAKD      +N +    QVV+ V D+ND  P   
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDR----GTNPKSARAQVVVTVKDMNDNAPTIE 388

Query: 2510 -------SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
                   +      ++ E+    T+V  +  +D+DEG N  +T  + G          ++
Sbjct: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448

Query: 2563 G-------LVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
            G        + T  PL  YEK   +++ +VA D G PPL  T  L V+V+DVNDN PVF 
Sbjct: 449  GSDSKKKYFLQTTTPL-DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
            +  + T +   E       + E+ A+D D G N  + YS       +    F I P +G 
Sbjct: 508  Q--SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG--LFTISPETGE 563

Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
            IQ    LDRE +  Y L +VA+D G P    T   L V + D +DN+P F+         
Sbjct: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL-VNVLDCNDNDPKFMLSGYN---- 618

Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGCLLVLRDL 2791
               +V E+ P  + VG VT  +D D+G NA V   +   N +  F +Q   G +L     
Sbjct: 619  --FSVMENMPALSPVGMVT-VIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSF 673

Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
            DRE+++ ++F +KA       PPR                V + + D ND  P  T    
Sbjct: 674  DREQQSTYTFQLKAVD--GGVPPRS-----------AYVGVTINVLDENDNAPYITAPSN 720

Query: 2852 TAG--VATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
            T+   +    ++G  + QV A D D G N+ + YSI
Sbjct: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI 756



 Score =  213 bits (541), Expect = 3e-54
 Identities = 208/744 (27%), Positives = 319/744 (42%), Gaps = 68/744 (9%)

Query: 1904 TTGIVTVNRPLDRERIPE-----------YKLTISVKDNPEN--PRIARRDYDLLLIFLS 1950
            T  I T    +DRE + E            +  +S+ D  +N  PR+     ++      
Sbjct: 105  TGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV-----Q 159

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
            D NDN P F        + EN+  G+   +     LA D D     V +Y+L        
Sbjct: 160  DINDNTPNFASPVITLAIPENTNIGSLFPIP----LASDRDAGPNGVASYELQAGPEAQE 215

Query: 2009 LFDINSSTGVVTVRSGVII----DREAFSPPILELLLLAEDIGL--LNSTAHLLITILDD 2062
            LF +  +      +  +I+    DRE +     +L +  +D G     S+A L +T+LD 
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQDGGSPPRASSALLRVTVLDT 273

Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLV 2121
            NDN P F   +    L EN P G SV+QV A D D G N E+ Y   +A    R L+ L 
Sbjct: 274  NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333

Query: 2122 --TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-LNPI 2178
              TG+I V    +DRE+  + R +V+A DRGT P S  A V + + D+ND+ P   +  I
Sbjct: 334  RNTGLITV-QGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392

Query: 2179 QTVS-------VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
              V+       + E     T +A +   D D     E   V  V   D    +    +  
Sbjct: 393  GLVTHQDGMANISEDVAEETAVALVQVSDRDEG---ENAAVTCVVAGDVPFQLRQASETG 449

Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTP 2291
            + +     +   +P++ E V  Y + +  +D+ +      +S  N+ L V V+DVNDN P
Sbjct: 450  SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNS-LKVQVVDVNDNAP 504

Query: 2292 QFKPFGITYYMERIL--EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
             F     T  +  +   E   PG  +  + A D D G N  + Y+L        +     
Sbjct: 505  VF-----TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559

Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
              G++    ++D E+       V A+D GSP       V + ++D NDN+P F    Y  
Sbjct: 560  ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619

Query: 2410 AVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKD 2469
            +V E++P  + +  VT  D D G  A ++ S+      F I   TG I    S DRE++ 
Sbjct: 620  SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQS 679

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS--VYENEPAGTS 2527
             Y     A D  G V    R   V V I VLD ND  P  + P  ++   +      G +
Sbjct: 680  TYTFQLKAVD--GGVPP--RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGET 735

Query: 2528 VITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVAT 2584
            V  + A D D G N EL YS+ G      F +   SG +T ++ ++   +    L V  +
Sbjct: 736  VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVS 795

Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNR 2608
            D G+PP +GT ++ + V +   NR
Sbjct: 796  DRGKPPRYGTALVHLYVNETLANR 819



 Score =  166 bits (421), Expect = 3e-40
 Identities = 174/657 (26%), Positives = 264/657 (40%), Gaps = 54/657 (8%)

Query: 40  LLISEDTPVGSSVTQLLAQDMDNDPLVFGVS------GEEASRFFAV------EPDTGVV 87
           L I E+T +GS     LA D D  P   GV+      G EA   F +      E     +
Sbjct: 175 LAIPENTNIGSLFPIPLASDRDAGPN--GVASYELQAGPEAQELFGLQVAEDQEEKQPQL 232

Query: 88  WLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN 144
            +   LDRE    + +   V D        +  + + V D NDNAP F    Y   + EN
Sbjct: 233 IVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN 292

Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSF-QPPS---QFFAIDSARGIVTVIRELDYETTQA 200
           +P+G  +  V A D D GA   + Y+F Q P    +   +D   G++TV   +D E    
Sbjct: 293 SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLST 352

Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP--------IFINLPYSTNIYEHSPPG 252
            + +V A D+  T P S  A + + + D+ D  P        +  +     NI E     
Sbjct: 353 LRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411

Query: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFI 311
           T V ++   D+D+G    +   +       +               L    PL Y     
Sbjct: 412 TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKD 471

Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
            T++   ++    P  +  T +  + V+D+NDNAP F  S   VA  E  + G    +  
Sbjct: 472 YTIEIVAVDSGNPPLSS--TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG---EVIA 526

Query: 372 QVVDKDENLGLNSMFEVYLVGNNSHH--FIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
           ++   D + G N+     L    +    F ISP + +      I+V   LD E  + Y+ 
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE------IQVKTSLDREQRESYEL 580

Query: 430 DLF-ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDND 488
            +  A+   P   G A V + +++ NDN P F    YN S+ EN+   + V  V   D D
Sbjct: 581 KVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD 640

Query: 489 AGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--R 546
            G   +V      D   F +   TG I+     D E    +T  + A DGG    +    
Sbjct: 641 KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700

Query: 547 VRINVLDVNDNVP--TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
           V INVLD NDN P  T   +     L         + ++ A D DS  N ++ YSI   +
Sbjct: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760

Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +G  F I  + G    +++   + E+  +GL  L V   D G PP   T  V + V
Sbjct: 761 PYG-LFQIGSHSG----AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  142 bits (357), Expect = 7e-33
 Identities = 141/539 (26%), Positives = 226/539 (41%), Gaps = 73/539 (13%)

Query: 2413 EDVPVGTIILTVTATDA--DSGNFALIEYSLGDGESKFAINPTTGDIYVL-SSLDREKKD 2469
            E+ P  T+I ++ A     D G+     Y L  G     ++  TGDI+   +S+DRE   
Sbjct: 66   EEQPPNTLIGSLAADYGFPDVGHL----YKLEVGAPYLRVDGKTGDIFTTETSIDREG-- 119

Query: 2470 HYILTALAKDNPGD------------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
               L       PGD            +  N     ++  I+V D+ND  P F+ P  + +
Sbjct: 120  ---LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLA 176

Query: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLE-GP-GVEAFHVDMDSGLVTTQRPL---- 2571
            + EN   G+     +A+D+D GPNG  +Y L+ GP   E F + +       Q  L    
Sbjct: 177  IPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMG 236

Query: 2572 ----QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP 2627
                + ++ + LT+   DGG PP   + +L V V+D NDN P F RP       + E  P
Sbjct: 237  NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA--ELSENSP 294

Query: 2628 LRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
            +  +V +V A D D+G N  + Y+F   A         +D  +GLI     +DRE  +  
Sbjct: 295  IGHSVIQVKANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL 353

Query: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ--LLTVPEHSPRGT 2745
               ++A D G   P      + V ++D++DN P       G   +Q  +  + E     T
Sbjct: 354  RFSVLAKDRGTN-PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIA-------------AGNEEKNFHLQPDGCLLVLRDLD 2792
             V  V    D DEG NA V   +A               + +K + LQ    L    D +
Sbjct: 413  AVALVQ-VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPL----DYE 467

Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
            + ++     +   S N    PP   + +L           +V + D+ND  P FT++   
Sbjct: 468  KVKDYTIEIVAVDSGN----PPLSSTNSL-----------KVQVVDVNDNAPVFTQSVTE 512

Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
                 + K G  + ++ A DAD G+N+ + YS+      + L   S + G++    S+D
Sbjct: 513  VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  265 bits (678), Expect = 4e-70
 Identities = 215/701 (30%), Positives = 323/701 (46%), Gaps = 62/701 (8%)

Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE 1791
            + V DINDN P F               G      LA DRD+GPNG   Y +  G    E
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 1792 FVISPVEGVLRVRKDVE-----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
                     L+V +D E           LDRE    Y+LTI  +D G PP +S+ L+ + 
Sbjct: 216  LF------GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269

Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL--TFNITAGNRERA 1898
            VLD NDN P          +SENSP+   V  V A+D+D G NA +  TF+       R 
Sbjct: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329

Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP- 1957
              ++  TG++TV  P+DRE +   + ++  KD   NP+ AR     +++ + D NDN P 
Sbjct: 330  LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQ---VVVTVKDMNDNAPT 386

Query: 1958 -------LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
                   L T     A + E+    T + ++       D D+   A VT  + G      
Sbjct: 387  IEIRGIGLVTHQDGMANISEDVAEETAVALVQ----VSDRDEGENAAVTCVVAGDVPFQL 442

Query: 2011 DINSSTGVVTVRSGVI-----IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
               S TG  + +   +     +D E      +E++ +      L+ST  L + ++D NDN
Sbjct: 443  RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502

Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA--GAQDRFLIHLVTG 2123
             P F+ +   V   EN  PG  + ++TA+D DSG N ELVY +E    A+  F I   TG
Sbjct: 503  APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562

Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
             I+V   ++DRE++ESY L VVA DRG+  L GTA V + + D ND+ P+F+      SV
Sbjct: 563  EIQV-KTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621

Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
            +E+    + +  +T ID D     +  +   V +D+ D         F +   TG+++  
Sbjct: 622  MENMPALSPVGMVTVIDGDKGENAQVQL--SVEQDNGD---------FVIQNGTGTILSS 670

Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
               +RE  +TY   L  +D    +P RS  V    +T+NVLD NDN P       T +  
Sbjct: 671  LSFDREQQSTYTFQLKAVDGG--VPPRSAYV---GVTINVLDENDNAPYITAPSNTSH-- 723

Query: 2304 RILEGATP-GTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
            ++L   T  G T+  VAA D D G+N  + Y++    P G  Q+  S +G +   + ++ 
Sbjct: 724  KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI-GSHSGAITLEKEIER 782

Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
                     V+ SD G PPR     V+L + +   N  + +
Sbjct: 783  RHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823



 Score =  261 bits (667), Expect = 8e-69
 Identities = 226/779 (29%), Positives = 347/779 (44%), Gaps = 72/779 (9%)

Query: 247 EHSPPGTTVRIITAIDQDKGRPR---------GIGYTIVSGNTNSIFALDYISGVLTLNG 297
           E  PP T +  + A   D G P          G  Y  V G T  IF  +     +   G
Sbjct: 66  EEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETS---IDREG 119

Query: 298 LLDRENPLYSHGFILT--VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV 355
           L + +N L     IL   V  T+L  + +P          I V DINDN P F S   ++
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPR----LLEGQIEVQDINDNTPNFASPVITL 175

Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
           AI E   +G   P+ +   D+D      + +E+         F +     Q +   ++ V
Sbjct: 176 AIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIV 234

Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
              LD E  D YD  +   +   P     A +++T+++ NDN P F +P Y   L EN  
Sbjct: 235 MGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSP 294

Query: 475 VGTSVLTVLATDNDAGTFGEVSYFFSDDPD----RFSLDKDTGLIMLIARLDYELIQRFT 530
           +G SV+ V A D+D G   E+ Y F   P+       LD++TGLI +   +D E +    
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR 354

Query: 531 LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQ--------KDAYVGALRENEPSVTQL 580
            +++A+D G    + R  V + V D+NDN PT +            +  + E+    T +
Sbjct: 355 FSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAV 414

Query: 581 VRLRATDEDSPPNNQIT--------YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
             ++ +D D   N  +T        + +  AS  GS      +     +  + PLDYE++
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYF-----LQTTTPLDYEKV 469

Query: 633 SNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
            +  I   ++A+D+GNPPL+ST  + ++V D NDN P F++    V+  EN   G  +  
Sbjct: 470 KDYTI--EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527

Query: 693 LNATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
           + A+D D         ++YSLE        F I+  +GEI   + LDRE +  Y L V A
Sbjct: 528 ITASDADSG---SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584

Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
            D G    Q  G ATV + +LD NDN P +  + Y  +++E  P  S V  V  +D D G
Sbjct: 585 ADRGSPSLQ--GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642

Query: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
           EN  +  S++  N  + + + TG I ++    DRE    +  +L         D G PP 
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSS-LSFDREQQSTYTFQL------KAVDGGVPPR 695

Query: 869 KATSSATVFVNLLDLNDNDPTFQNLPFVAEVL--EGIPAGVSIYQVVAIDLDEGLNGLVS 926
            A    T  +N+LD NDN P        +  L       G ++ QV A D D G+N  + 
Sbjct: 696 SAYVGVT--INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753

Query: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV 985
           Y +  G P   F I S SG +    E++R     ++L V  SD G P +  T+ + ++V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  256 bits (653), Expect = 3e-67
 Identities = 211/682 (30%), Positives = 321/682 (47%), Gaps = 51/682 (7%)

Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
            Q+ + DINDN P   SP    +++ EN   G+      A+DRD G N V SY +  G + 
Sbjct: 155  QIEVQDINDNTPNFASPV-ITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEA 213

Query: 1574 MA-FRMDRISGEIATRP-----APPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDE 1627
               F +     +   +P        DRER   Y L   V+D G+P  +++  + VT++D 
Sbjct: 214  QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273

Query: 1628 NDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI-VAGNIVNTF-RI 1685
            NDNAP F++P YE  L E    +  S+I ++A D D+G N  + Y    A  +V    R+
Sbjct: 274  NDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 1686 DRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
            DR+ G+IT    +D E +S  R++++       P      ++   V+V V D+NDN PT 
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTI 387

Query: 1745 P-------RDYEGPFEVTEGQPGPRVWTFL-AHDRDSGPN--------GQVEYSIMDGDP 1788
                       +G   ++E          +   DRD G N        G V + +     
Sbjct: 388  EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447

Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
             G    S  +    ++    LD E +  Y + I A D G PPLSST  + ++V+D+NDN 
Sbjct: 448  TG----SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503

Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF-INATTGI 1907
            PV       +   EN+     +A + ASDADSG NA L +++      +  F I+  TG 
Sbjct: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563

Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
            + V   LDRE+   Y+L +   D   +P +  +    +L+ + D NDN P F  S Y   
Sbjct: 564  IQVKTSLDREQRESYELKVVAADR-GSPSL--QGTATVLVNVLDCNDNDPKFMLSGYNFS 620

Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
            VMEN PA +P+    G +  +D D+   A V    +   +G F I + TG  T+ S +  
Sbjct: 621  VMENMPALSPV----GMVTVIDGDKGENAQVQLS-VEQDNGDFVIQNGTG--TILSSLSF 673

Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH--LLENCPPG 2085
            DRE  S    +L  +   +   ++   + I +LD+NDN P  +  + T H  L      G
Sbjct: 674  DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733

Query: 2086 FSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTV 2144
             +V QV A D DSG+N EL+Y I  G     F I   +G I +    I+R     +RL V
Sbjct: 734  ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERRHHGLHRLVV 792

Query: 2145 VATDRGTVPLSGTAIVTILIDD 2166
              +DRG  P  GTA+V + +++
Sbjct: 793  KVSDRGKPPRYGTALVHLYVNE 814



 Score =  253 bits (646), Expect = 2e-66
 Identities = 213/701 (30%), Positives = 322/701 (45%), Gaps = 52/701 (7%)

Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
            + V+DIND  P F     + L + E   IG+   +  A+DRD+G  G+ +Y + +G E +
Sbjct: 156  IEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214

Query: 1256 F--------EIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
                     + +E    +I +  LD E   SY + +   D   P       + +T+L+  
Sbjct: 215  ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274

Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKID 1365
            D A +F   SYEA + EN  +G  +++V+A   D     +I Y F+       + L ++D
Sbjct: 275  DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV-VRRLLRLD 333

Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTS-- 1422
              TG+ITVQG VDRE       +V+A D G    S   +V +TV D NDN+P  +     
Sbjct: 334  RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393

Query: 1423 -----DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG---NIAGAFEIVTTND 1474
                 D   +I ED      VA V+  D D G N  V   +A      +  A E  T +D
Sbjct: 394  LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE--TGSD 451

Query: 1475 SIGEVFV--ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
            S  + F+    PLD E++  Y +++VA D G PP    + L+V ++D+NDN PV      
Sbjct: 452  SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511

Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-EGNKDMAFRMDRISGEIATRPAP 1591
              V+  EN   G  + ++ A+D D G N+ L Y +  E      F +   +GEI  + + 
Sbjct: 512  -EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570

Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
             DRE++  Y L     D G+P+L  T  V V ++D NDN P F    Y   + E    L+
Sbjct: 571  -DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629

Query: 1652 -TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
               ++T+  +D D+G N  V  ++   N    F I    G I ++   D E     YT  
Sbjct: 630  PVGMVTV--IDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDRE-QQSTYTFQ 684

Query: 1711 VTATDQ-CPILSHRLTSTTTVLVNVNDINDNVP--TFPRDYEGPFEVTEGQPGPRVWTFL 1767
            + A D   P  S    +   V +NV D NDN P  T P +        + + G  V    
Sbjct: 685  LKAVDGGVPPRS----AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA 740

Query: 1768 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
            A D DSG N ++ YSI  G+P G F I    G + + K++E  R     + L +   DRG
Sbjct: 741  AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE--RRHHGLHRLVVKVSDRG 798

Query: 1828 MPPLSSTMLVGIRVLDINDNDPVL-------LNLPMNITIS 1861
             PP   T LV + V +   N  +L       L+ P++I I+
Sbjct: 799  KPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIA 839



 Score =  252 bits (644), Expect = 4e-66
 Identities = 235/801 (29%), Positives = 345/801 (43%), Gaps = 80/801 (9%)

Query: 927  YRMPVGMPRMDFLINSSSGVVVTT-TELDRERIAEYQLRVVASDAGTPTKSSTSTLT--- 982
            Y++ VG P +   ++  +G + TT T +DRE + E Q ++         + S + L    
Sbjct: 90   YKLEVGAPYLR--VDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147

Query: 983  --------IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
                    I V D+ND TP F   V  +++ E+            +D D G N   SY +
Sbjct: 148  SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 207

Query: 1035 TGGNVDGKFSVGYRDAVVRT-------VVG-LDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
              G  + +   G + A  +        V+G LDRE   +Y L ++  D G   +    +A
Sbjct: 208  QAGP-EAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPR--ASSA 264

Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNH 1146
             + VTVLD NDN P F + SYEA + E+ P GHS++Q+KA D+D+G    + Y       
Sbjct: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324

Query: 1147 --GNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
                  R+  + GL+ ++GP  +DRE  S+    V A +    P  +  +V+V V+D+ND
Sbjct: 325  VVRRLLRLDRNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382

Query: 1204 EAPVF-------TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKF 1256
             AP            Q     + E     T+V +VQ +DRD G+   V   +      + 
Sbjct: 383  NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442

Query: 1257 EIDESTG-------LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE 1309
                 TG        + T   LDYE    Y + + A D   P      S+ + +++  D 
Sbjct: 443  RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502

Query: 1310 AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
            A  F+ +  E A  EN   G  I  + A   D+ +     ++      AK LF I   TG
Sbjct: 503  APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562

Query: 1370 VITVQGLVDREKGDFYTLTVV-ADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
             I V+  +DRE+ + Y L VV AD G P +  T  V + VLD NDN P+F   S    S+
Sbjct: 563  EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNFSV 621

Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
             E+ P    V  V   D D G N QV  S+   N  G F I    +  G +  +   DRE
Sbjct: 622  MENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVI---QNGTGTILSSLSFDRE 676

Query: 1489 ELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS-VNENVGGGTAV 1547
            +   Y  Q+ A D G PPR     + + +LD NDN P I +P   +   +      G  V
Sbjct: 677  QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736

Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
             QV A D D G+N+ L Y I  GN    F++   SG I T     +R     + LV  V 
Sbjct: 737  SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795

Query: 1608 DEGTPTL--SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-- 1663
            D G P    +A  H+YV       N  +  +   E LL    DT          LD+D  
Sbjct: 796  DRGKPPRYGTALVHLYV-------NETLANRTLLETLLGHSLDT---------PLDIDIA 839

Query: 1664 -------EGPNGTVTYAIVAG 1677
                       G + + +VAG
Sbjct: 840  GDPEYERSKQRGNILFGVVAG 860



 Score =  230 bits (587), Expect = 2e-59
 Identities = 194/691 (28%), Positives = 305/691 (44%), Gaps = 35/691 (5%)

Query: 530  TLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
            ++T + ++G      G++ +   D+NDN P F       A+ EN    +      A+D D
Sbjct: 139  SITDLVQNGSPRLLEGQIEVQ--DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 590  SPPNNQITYSIVSASAFGSYFDISLYEGYGV----ISVSRPLDYEQISNGLIYLTVMAMD 645
            + PN   +Y + +       F + + E        + V   LD E+  +    LT+   D
Sbjct: 197  AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQD 254

Query: 646  AGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG 705
             G+PP  S+  + + V D NDN P F +P+Y   + EN   G +V+ + A D D+     
Sbjct: 255  GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314

Query: 706  QESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT 763
             E   +      +   R++  +G IT    +DRE  S     V A D G   N K+  A 
Sbjct: 315  IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT--NPKSARAQ 372

Query: 764  VNITLLDINDNHPTWKDAPYYI--------NLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
            V +T+ D+NDN PT +     +        N+ E    ++ V  V   D D GEN  +  
Sbjct: 373  VVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC 432

Query: 816  SIQPPNKFYSLN-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
             +     F     S TG        L    P  +E      I +   D G PPL +T+S 
Sbjct: 433  VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL 492

Query: 875  TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGM 933
             V V  +D+NDN P F          E    G  I ++ A D D G N  + Y + P   
Sbjct: 493  KVQV--VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550

Query: 934  PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETP 993
             +  F I+  +G +   T LDRE+   Y+L+VVA+D G+P+   T+T+ ++VLD ND  P
Sbjct: 551  AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610

Query: 994  TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVR 1053
             F  + YN SV E++P    V  +   D D G NA++   +   N  G F +      + 
Sbjct: 611  KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTIL 668

Query: 1054 TVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFL---QSSYEA 1109
            + +  DRE  + Y   L+A+D G P    + G   V + VLD NDN P       +S++ 
Sbjct: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---VTINVLDENDNAPYITAPSNTSHKL 725

Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
              P+    G ++ Q+ A D D G    + Y I  GN    F+I   +G +    + ++R 
Sbjct: 726  LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERR 783

Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
             +  H L+V+  +    P   +  V +YV +
Sbjct: 784  HHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814



 Score =  228 bits (581), Expect = 8e-59
 Identities = 211/707 (29%), Positives = 329/707 (46%), Gaps = 66/707 (9%)

Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTD 2221
            I + DIND+ P F +P+ T+++ E+   G++     A D D  P       G+ + +   
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPN------GVASYEL-- 207

Query: 2222 RLVPNQEDAFAVNI------NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
            +  P  ++ F + +          ++V   ++RE   +Y++T+ V D  S  P R+ S  
Sbjct: 208  QAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS--PPRASS-- 263

Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
             A L V VLD NDN P+F+      Y   + E +  G ++I V A D D+G N  + YT 
Sbjct: 264  -ALLRVTVLDTNDNAPKFER---PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF 319

Query: 2336 LDL--VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
                 V    ++L D + G +     VD E++  L F+V A D G+ P++A   V + + 
Sbjct: 320  HQAPEVVRRLLRL-DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378

Query: 2394 DINDNNPIFD-----QPSYQEA---VFEDVPVGTIILTVTATDADSG-NFALIEYSLGDG 2444
            D+NDN P  +       ++Q+    + EDV   T +  V  +D D G N A+     GD 
Sbjct: 379  DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV 438

Query: 2445 ESKFAINPTTGD-------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVI 2497
              +      TG        +   + LD EK   Y +  +A D+     S+   NS++V  
Sbjct: 439  PFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST--NSLKV-- 494

Query: 2498 QVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEA- 2555
            QV+DVND  P F++     +  EN   G  +  + A+D D G N EL YSLE  P  +  
Sbjct: 495  QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554

Query: 2556 FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVR 2613
            F +  ++G +  +  L  +  E + L VVA D G P L GT  +LV V+D NDN P F+ 
Sbjct: 555  FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614

Query: 2614 PPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
              +G    + E +P  S V  V   D D+G N  V+ S  +  G+     F+I   +G I
Sbjct: 615  --SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTI 667

Query: 2674 QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ 2733
             ++   DRE Q+ Y+  L A D G P P      + + + D +DN P    P   S  ++
Sbjct: 668  LSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTS--HK 724

Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLD 2792
            LLT    +  G  V  V  A D D G NA + Y IA GN    F +    G + + ++++
Sbjct: 725  LLT--PQTRLGETVSQVA-AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781

Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
            R    +   +VK S      PPR  +  + L  + TL   R +LE +
Sbjct: 782  RRHHGLHRLVVKVSDRGK--PPRYGTALVHLYVNETLAN-RTLLETL 825



 Score =  226 bits (576), Expect = 3e-58
 Identities = 194/664 (29%), Positives = 301/664 (45%), Gaps = 52/664 (7%)

Query: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ--PPSQ- 176
           I+V D+NDN P F +   ++ IPENT +G+   I  A+D D G  G   Y  Q  P +Q 
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 177 FFAIDSA------RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQ 230
            F +  A      +  + V+  LD E   +Y LT+   D   + P ++ A L + + D  
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD-GGSPPRASSALLRVTVLDTN 274

Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDY 288
           D  P F    Y   + E+SP G +V  + A D D+G    I YT          +  LD 
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334

Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
            +G++T+ G +DRE+       + T++ + L  DR  +  +      + V D+NDNAP  
Sbjct: 335 NTGLITVQGPVDRED-------LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387

Query: 349 --------NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHF-I 399
                      +    I+E      A+ L +QV D+DE  G N+     + G+       
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVAL-VQVSDRDE--GENAAVTCVVAGDVPFQLRQ 444

Query: 400 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRP 458
            S T    K    ++   PLDYE V  Y  ++ A +S  P       +K+ +++ NDN P
Sbjct: 445 ASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504

Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP---DRFSLDKDTGLI 515
           +F+Q +  ++  EN   G  +  + A+D D+G+  E+ Y    +P     F++  +TG I
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564

Query: 516 MLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
            +   LD E  + + L ++A D G    + T  V +NVLD NDN P F    Y  ++ EN
Sbjct: 565 QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMEN 624

Query: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
            P+++ +  +   D D   N Q+  S+   +      D  +  G G I  S   D EQ S
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQS 679

Query: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA--YFVSVVENIMAGATVL 691
                L   A+D G PP ++ V VTI V DENDN P  + P+      +      G TV 
Sbjct: 680 TYTFQL--KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737

Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRA 748
            + A D D         +IYS+ G      F+I + SG IT    ++R     + L+V+ 
Sbjct: 738 QVAAEDFDSG---VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794

Query: 749 VDGG 752
            D G
Sbjct: 795 SDRG 798



 Score =  213 bits (543), Expect = 2e-54
 Identities = 190/636 (29%), Positives = 287/636 (45%), Gaps = 66/636 (10%)

Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---- 2336
            + V D+NDNTP F    IT     I E    G+      A D D G NG+ +Y L     
Sbjct: 156  IEVQDINDNTPNFASPVITL---AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212

Query: 2337 --DLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
              +L      + ++    ++I    +D E     + T++  D GSPPRA+   + + ++D
Sbjct: 213  AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272

Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG----ESKFAI 2450
             NDN P F++PSY+  + E+ P+G  ++ V A D+D G  A IEY+             +
Sbjct: 273  TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF- 2509
            +  TG I V   +DRE       + LAKD      +N +    QVV+ V D+ND  P   
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDR----GTNPKSARAQVVVTVKDMNDNAPTIE 388

Query: 2510 -------SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
                   +      ++ E+    T+V  +  +D+DEG N  +T  + G          ++
Sbjct: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448

Query: 2563 G-------LVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
            G        + T  PL  YEK   +++ +VA D G PPL  T  L V+V+DVNDN PVF 
Sbjct: 449  GSDSKKKYFLQTTTPL-DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507

Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
            +  + T +   E       + E+ A+D D G N  + YS       +    F I P +G 
Sbjct: 508  Q--SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG--LFTISPETGE 563

Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
            IQ    LDRE +  Y L +VA+D G P    T   L V + D +DN+P F+         
Sbjct: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL-VNVLDCNDNDPKFMLSGYN---- 618

Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGCLLVLRDL 2791
               +V E+ P  + VG VT  +D D+G NA V   +   N +  F +Q   G +L     
Sbjct: 619  --FSVMENMPALSPVGMVT-VIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSF 673

Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
            DRE+++ ++F +KA       PPR                V + + D ND  P  T    
Sbjct: 674  DREQQSTYTFQLKAVD--GGVPPRS-----------AYVGVTINVLDENDNAPYITAPSN 720

Query: 2852 TAG--VATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
            T+   +    ++G  + QV A D D G N+ + YSI
Sbjct: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI 756



 Score =  213 bits (541), Expect = 3e-54
 Identities = 208/744 (27%), Positives = 319/744 (42%), Gaps = 68/744 (9%)

Query: 1904 TTGIVTVNRPLDRERIPE-----------YKLTISVKDNPEN--PRIARRDYDLLLIFLS 1950
            T  I T    +DRE + E            +  +S+ D  +N  PR+     ++      
Sbjct: 105  TGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV-----Q 159

Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
            D NDN P F        + EN+  G+   +     LA D D     V +Y+L        
Sbjct: 160  DINDNTPNFASPVITLAIPENTNIGSLFPIP----LASDRDAGPNGVASYELQAGPEAQE 215

Query: 2009 LFDINSSTGVVTVRSGVII----DREAFSPPILELLLLAEDIGL--LNSTAHLLITILDD 2062
            LF +  +      +  +I+    DRE +     +L +  +D G     S+A L +T+LD 
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQDGGSPPRASSALLRVTVLDT 273

Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLV 2121
            NDN P F   +    L EN P G SV+QV A D D G N E+ Y   +A    R L+ L 
Sbjct: 274  NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333

Query: 2122 --TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-LNPI 2178
              TG+I V    +DRE+  + R +V+A DRGT P S  A V + + D+ND+ P   +  I
Sbjct: 334  RNTGLITV-QGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392

Query: 2179 QTVS-------VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
              V+       + E     T +A +   D D     E   V  V   D    +    +  
Sbjct: 393  GLVTHQDGMANISEDVAEETAVALVQVSDRDEG---ENAAVTCVVAGDVPFQLRQASETG 449

Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTP 2291
            + +     +   +P++ E V  Y + +  +D+ +      +S  N+ L V V+DVNDN P
Sbjct: 450  SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNS-LKVQVVDVNDNAP 504

Query: 2292 QFKPFGITYYMERIL--EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
             F     T  +  +   E   PG  +  + A D D G N  + Y+L        +     
Sbjct: 505  VF-----TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559

Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
              G++    ++D E+       V A+D GSP       V + ++D NDN+P F    Y  
Sbjct: 560  ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619

Query: 2410 AVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKD 2469
            +V E++P  + +  VT  D D G  A ++ S+      F I   TG I    S DRE++ 
Sbjct: 620  SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQS 679

Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS--VYENEPAGTS 2527
             Y     A D  G V    R   V V I VLD ND  P  + P  ++   +      G +
Sbjct: 680  TYTFQLKAVD--GGVPP--RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGET 735

Query: 2528 VITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVAT 2584
            V  + A D D G N EL YS+ G      F +   SG +T ++ ++   +    L V  +
Sbjct: 736  VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVS 795

Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNR 2608
            D G+PP +GT ++ + V +   NR
Sbjct: 796  DRGKPPRYGTALVHLYVNETLANR 819



 Score =  166 bits (421), Expect = 3e-40
 Identities = 174/657 (26%), Positives = 264/657 (40%), Gaps = 54/657 (8%)

Query: 40  LLISEDTPVGSSVTQLLAQDMDNDPLVFGVS------GEEASRFFAV------EPDTGVV 87
           L I E+T +GS     LA D D  P   GV+      G EA   F +      E     +
Sbjct: 175 LAIPENTNIGSLFPIPLASDRDAGPN--GVASYELQAGPEAQELFGLQVAEDQEEKQPQL 232

Query: 88  WLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN 144
            +   LDRE    + +   V D        +  + + V D NDNAP F    Y   + EN
Sbjct: 233 IVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN 292

Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSF-QPPS---QFFAIDSARGIVTVIRELDYETTQA 200
           +P+G  +  V A D D GA   + Y+F Q P    +   +D   G++TV   +D E    
Sbjct: 293 SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLST 352

Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP--------IFINLPYSTNIYEHSPPG 252
            + +V A D+  T P S  A + + + D+ D  P        +  +     NI E     
Sbjct: 353 LRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411

Query: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFI 311
           T V ++   D+D+G    +   +       +               L    PL Y     
Sbjct: 412 TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKD 471

Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
            T++   ++    P  +  T +  + V+D+NDNAP F  S   VA  E  + G    +  
Sbjct: 472 YTIEIVAVDSGNPPLSS--TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG---EVIA 526

Query: 372 QVVDKDENLGLNSMFEVYLVGNNSHH--FIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
           ++   D + G N+     L    +    F ISP + +      I+V   LD E  + Y+ 
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE------IQVKTSLDREQRESYEL 580

Query: 430 DLF-ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDND 488
            +  A+   P   G A V + +++ NDN P F    YN S+ EN+   + V  V   D D
Sbjct: 581 KVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD 640

Query: 489 AGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--R 546
            G   +V      D   F +   TG I+     D E    +T  + A DGG    +    
Sbjct: 641 KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700

Query: 547 VRINVLDVNDNVP--TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
           V INVLD NDN P  T   +     L         + ++ A D DS  N ++ YSI   +
Sbjct: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760

Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
            +G  F I  + G    +++   + E+  +GL  L V   D G PP   T  V + V
Sbjct: 761 PYG-LFQIGSHSG----AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  142 bits (357), Expect = 7e-33
 Identities = 141/539 (26%), Positives = 226/539 (41%), Gaps = 73/539 (13%)

Query: 2413 EDVPVGTIILTVTATDA--DSGNFALIEYSLGDGESKFAINPTTGDIYVL-SSLDREKKD 2469
            E+ P  T+I ++ A     D G+     Y L  G     ++  TGDI+   +S+DRE   
Sbjct: 66   EEQPPNTLIGSLAADYGFPDVGHL----YKLEVGAPYLRVDGKTGDIFTTETSIDREG-- 119

Query: 2470 HYILTALAKDNPGD------------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
               L       PGD            +  N     ++  I+V D+ND  P F+ P  + +
Sbjct: 120  ---LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLA 176

Query: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLE-GP-GVEAFHVDMDSGLVTTQRPL---- 2571
            + EN   G+     +A+D+D GPNG  +Y L+ GP   E F + +       Q  L    
Sbjct: 177  IPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMG 236

Query: 2572 ----QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP 2627
                + ++ + LT+   DGG PP   + +L V V+D NDN P F RP       + E  P
Sbjct: 237  NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA--ELSENSP 294

Query: 2628 LRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
            +  +V +V A D D+G N  + Y+F   A         +D  +GLI     +DRE  +  
Sbjct: 295  IGHSVIQVKANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL 353

Query: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ--LLTVPEHSPRGT 2745
               ++A D G   P      + V ++D++DN P       G   +Q  +  + E     T
Sbjct: 354  RFSVLAKDRGTN-PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412

Query: 2746 LVGNVTGAVDADEGPNAIVYYFIA-------------AGNEEKNFHLQPDGCLLVLRDLD 2792
             V  V    D DEG NA V   +A               + +K + LQ    L    D +
Sbjct: 413  AVALVQ-VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPL----DYE 467

Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
            + ++     +   S N    PP   + +L           +V + D+ND  P FT++   
Sbjct: 468  KVKDYTIEIVAVDSGN----PPLSSTNSL-----------KVQVVDVNDNAPVFTQSVTE 512

Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
                 + K G  + ++ A DAD G+N+ + YS+      + L   S + G++    S+D
Sbjct: 513  VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 124,664,309
Number of Sequences: 37866
Number of extensions: 5790916
Number of successful extensions: 49687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 11426
Number of HSP's gapped (non-prelim): 3168
length of query: 3354
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3233
effective length of database: 13,665,732
effective search space: 44181311556
effective search space used: 44181311556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.