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Search of human proteins with 18490978
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18490978 intermediate filament family orphan isoform 2 [Homo
sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18490978 intermediate filament family orphan isoform 2 [Homo ... 1115 0.0
gi|89213250 intermediate filament family orphan isoform 4 [Homo ... 1105 0.0
gi|210147457 intermediate filament family orphan 2 [Homo sapiens] 541 e-154
gi|89213247 intermediate filament family orphan isoform 3 [Homo ... 395 e-110
gi|62414289 vimentin [Homo sapiens] 88 2e-17
gi|28173564 keratin 73 [Homo sapiens] 84 3e-16
gi|15618995 keratin 71 [Homo sapiens] 80 5e-15
gi|89357932 keratin 5b [Homo sapiens] 77 3e-14
gi|153791158 keratin 75 [Homo sapiens] 77 5e-14
gi|4504919 keratin 8 [Homo sapiens] 75 2e-13
gi|148612803 keratin 6 irs4 [Homo sapiens] 74 4e-13
gi|119395754 keratin 5 [Homo sapiens] 72 1e-12
gi|109148552 keratin 3 [Homo sapiens] 72 2e-12
gi|109255249 keratin 4 [Homo sapiens] 71 2e-12
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 70 4e-12
gi|28372503 keratin 72 isoform 1 [Homo sapiens] 70 5e-12
gi|226246663 keratin 72 isoform 1 [Homo sapiens] 70 5e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 70 5e-12
gi|55749932 desmin [Homo sapiens] 69 9e-12
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 68 2e-11
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 68 2e-11
gi|155969697 keratin 6C [Homo sapiens] 68 3e-11
gi|153791670 keratin 76 [Homo sapiens] 68 3e-11
gi|67782365 keratin 7 [Homo sapiens] 67 3e-11
gi|5031839 keratin 6A [Homo sapiens] 67 3e-11
gi|119395750 keratin 1 [Homo sapiens] 66 1e-10
gi|119703753 keratin 6B [Homo sapiens] 66 1e-10
gi|14917117 keratin 33A [Homo sapiens] 64 5e-10
gi|125628636 keratin 80 isoform a [Homo sapiens] 63 6e-10
gi|125628632 keratin 80 isoform b [Homo sapiens] 63 6e-10
>gi|18490978 intermediate filament family orphan isoform 2 [Homo
sapiens]
Length = 559
Score = 1115 bits (2883), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP 60
MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP
Sbjct: 1 MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP 60
Query: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG 120
PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG
Sbjct: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG 120
Query: 121 RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS 180
RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS
Sbjct: 121 RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS 180
Query: 181 TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA 240
TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA
Sbjct: 181 TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA 240
Query: 241 LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE 300
LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE
Sbjct: 241 LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE 300
Query: 301 LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPS 360
LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPS
Sbjct: 301 LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPS 360
Query: 361 MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD 420
MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD
Sbjct: 361 MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD 420
Query: 421 SLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQI 480
SLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQI
Sbjct: 421 SLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQI 480
Query: 481 ELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPP 540
ELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPP
Sbjct: 481 ELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPP 540
Query: 541 PPSEAEDSDRDVSSDSSMR 559
PPSEAEDSDRDVSSDSSMR
Sbjct: 541 PPSEAEDSDRDVSSDSSMR 559
>gi|89213250 intermediate filament family orphan isoform 4 [Homo
sapiens]
Length = 563
Score = 1105 bits (2857), Expect = 0.0
Identities = 559/563 (99%), Positives = 559/563 (99%), Gaps = 4/563 (0%)
Query: 1 MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP 60
MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP
Sbjct: 1 MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP 60
Query: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG 120
PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG
Sbjct: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG 120
Query: 121 RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS 180
RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS
Sbjct: 121 RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS 180
Query: 181 TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA 240
TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA
Sbjct: 181 TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA 240
Query: 241 LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE 300
LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE
Sbjct: 241 LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE 300
Query: 301 LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQ--- 357
LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQ
Sbjct: 301 LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQKKL 360
Query: 358 VPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFED 417
VPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFED
Sbjct: 361 VPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFED 420
Query: 418 DCDSLTWEETEETLLLWEDFSGYAMAAAEAQGE-QEDSLEKVIKDTESLFKTREKEYQET 476
DCDSLTWEETEETLLLWEDFSGYAMAAAEAQGE QEDSLEKVIKDTESLFKTREKEYQET
Sbjct: 421 DCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQQEDSLEKVIKDTESLFKTREKEYQET 480
Query: 477 IDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLS 536
IDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLS
Sbjct: 481 IDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLS 540
Query: 537 DPPPPPSEAEDSDRDVSSDSSMR 559
DPPPPPSEAEDSDRDVSSDSSMR
Sbjct: 541 DPPPPPSEAEDSDRDVSSDSSMR 563
>gi|210147457 intermediate filament family orphan 2 [Homo sapiens]
Length = 517
Score = 541 bits (1393), Expect = e-154
Identities = 313/537 (58%), Positives = 371/537 (69%), Gaps = 37/537 (6%)
Query: 19 LAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAMALRNDLGSNINVLK 78
L G + + G GGG P G GPGP+P A ALR+DLGSNI++LK
Sbjct: 6 LFGEMALAFGCPPGGGGGGCP------GGGGGGGGAGPGPSPVTA-ALRDDLGSNIHLLK 58
Query: 79 TLNLRFRCFLAKVHELERRNRLLEKQL-QQALEEGKQGRRGLGRRDQAVQTG--FVSPIR 135
LN+RFRCFLAKVHELERRNRLLEKQL QQ E ++ R R+QAVQTG + P
Sbjct: 59 GLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPA 118
Query: 136 PLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGT 195
P G L S A + A A + L S Y +PGT
Sbjct: 119 PGG--------------GHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGR----LPGT 160
Query: 196 IWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 255
IWS++ RR G G T VQGPG+SWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY
Sbjct: 161 IWSYTQVRRTGGGGVET-VQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 219
Query: 256 KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSEL 315
KRRWEEE R+ LQ V+ LQE AQEADA QEE+ K+E+LKAELVVFKGLMS+ +++L
Sbjct: 220 KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDL 279
Query: 316 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRERKAAVEED 375
DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRN ED+ ++FQV +K+ERK A ++D
Sbjct: 280 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVP---KKKERKVASDDD 336
Query: 376 TSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLRE-YDFEDDCDSLTWEETEETLLLW 434
S + E R D +E +++I +EM+RM NQLRE +DF+DDCDSLTWEE E+TLLLW
Sbjct: 337 ISEQDGEVNRFSD---DEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLW 393
Query: 435 EDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRH 494
EDF+ + QGEQE++L +I +TES FKTR+KEYQETI QIELELATAK+DMNRH
Sbjct: 394 EDFTN-CNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRH 452
Query: 495 LHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAEDSDRD 551
LHEYMEMCSMKRGLDVQMETCRRLI S DR SP+ ++V SD ++ +R+
Sbjct: 453 LHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGSTDEIQDEFERE 509
>gi|89213247 intermediate filament family orphan isoform 3 [Homo
sapiens]
Length = 200
Score = 395 bits (1016), Expect = e-110
Identities = 199/200 (99%), Positives = 199/200 (99%), Gaps = 1/200 (0%)
Query: 361 MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD 420
MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD
Sbjct: 1 MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD 60
Query: 421 SLTWEETEETLLLWEDFSGYAMAAAEAQGEQ-EDSLEKVIKDTESLFKTREKEYQETIDQ 479
SLTWEETEETLLLWEDFSGYAMAAAEAQGEQ EDSLEKVIKDTESLFKTREKEYQETIDQ
Sbjct: 61 SLTWEETEETLLLWEDFSGYAMAAAEAQGEQQEDSLEKVIKDTESLFKTREKEYQETIDQ 120
Query: 480 IELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPP 539
IELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPP
Sbjct: 121 IELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPP 180
Query: 540 PPPSEAEDSDRDVSSDSSMR 559
PPPSEAEDSDRDVSSDSSMR
Sbjct: 181 PPPSEAEDSDRDVSSDSSMR 200
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 87.8 bits (216), Expect = 2e-17
Identities = 77/311 (24%), Positives = 139/311 (44%), Gaps = 55/311 (17%)
Query: 237 EIRALYNVLAKVKRERDEY-------KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
++ L N A+V+ ERD + + +EE R + ++ + +++ A + +
Sbjct: 160 QVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLD 219
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KVE L+ E+ K L + EL +IQE+ +++D+D+ + D+TA L DV QQ
Sbjct: 220 LERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKP-DLTAALRDVRQQY-- 276
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E AA +L E+E + + A N+ +++ +
Sbjct: 277 -----------------ESVAA----KNLQEAEEWYKSKFADLSEAANRNNDALRQAKQE 315
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
EY SLT E +A +SLE+ +++ E F
Sbjct: 316 STEY--RRQVQSLTCE-------------------VDALKGTNESLERQMREMEENFAVE 354
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKS-- 527
YQ+TI +++ E+ K +M RHL EY ++ ++K LD+++ T R+L+ R S
Sbjct: 355 AANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLP 414
Query: 528 -PAFTAVPLSD 537
P F+++ L +
Sbjct: 415 LPNFSSLNLRE 425
Score = 30.8 bits (68), Expect = 3.4
Identities = 15/37 (40%), Positives = 25/37 (67%)
Query: 77 LKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGK 113
L+ LN RF ++ KV LE++N++L +L+Q +GK
Sbjct: 107 LQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGK 143
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 84.0 bits (206), Expect = 3e-16
Identities = 72/302 (23%), Positives = 135/302 (44%), Gaps = 44/302 (14%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q++T++ + L + L V+ ++YK+R+EEE R ++ L+++ A + E
Sbjct: 193 QLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVE 252
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ FK L +++ + I + ++ + MD R +D+ + + +V Q
Sbjct: 253 LQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQ--Y 310
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ RK + +A T E + GD+ + T I+ E+ R++ +
Sbjct: 311 EEI----------ARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEIS-ELTRLIQR 359
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR + E+ +Q +LE I D E
Sbjct: 360 LR-------------------------------SEIESVKKQCANLETAIADAEQRGDCA 388
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPA 529
K+ + +D++E L AK ++ R L EY E+ S+K LD+++ T R+L+ R S
Sbjct: 389 LKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGE 448
Query: 530 FT 531
+T
Sbjct: 449 YT 450
Score = 29.6 bits (65), Expect = 7.6
Identities = 29/133 (21%), Positives = 59/133 (44%), Gaps = 18/133 (13%)
Query: 229 VQIDTITPEIRALYNVLAKVKRERDE--YKRRWEEEYTVRIQLQDRVNELQEEAQEADAC 286
+ +D+I E+RA Y +A+ + E Y+ +++E + D + + E E
Sbjct: 297 LDLDSIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRL 356
Query: 287 QEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDV--A 344
+ L ++E +K + + L+T I + + D C D AKL ++ A
Sbjct: 357 IQRLRSEIESVKKQ-----------CANLETAIADAEQRGD---CALKDARAKLDELEGA 402
Query: 345 QQRNCEDMIQMFQ 357
Q+ E++ +M +
Sbjct: 403 LQQAKEELARMLR 415
>gi|15618995 keratin 71 [Homo sapiens]
Length = 523
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/301 (23%), Positives = 135/301 (44%), Gaps = 44/301 (14%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q++T++ + L + L V+ ++YK+R+EEE R ++ L+++ A A + E
Sbjct: 191 QLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVE 250
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KVE + E+ F+ L ++++ + I + ++ + MD R +D+ + + +V Q
Sbjct: 251 LQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQ--Y 308
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ K + +A T E + GD+ ++T I+ E+ R++ +
Sbjct: 309 EEI----------ALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEIS-ELTRLIQR 357
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
+R + E +Q +LE I D E
Sbjct: 358 IR-------------------------------SEIENVKKQASNLETAIADAEQRGDNA 386
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPA 529
K+ + +D++E L AK ++ R L EY E+ S+K LD+++ T R+L+ R S
Sbjct: 387 LKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGE 446
Query: 530 F 530
F
Sbjct: 447 F 447
>gi|89357932 keratin 5b [Homo sapiens]
Length = 520
Score = 77.4 bits (189), Expect = 3e-14
Identities = 76/311 (24%), Positives = 131/311 (42%), Gaps = 50/311 (16%)
Query: 225 DGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEAD 284
D + Q++ + E AL L + + +EYK ++EEE R L++ L+++
Sbjct: 167 DQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVF 226
Query: 285 ACQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVA 344
+ EL K+E L+ L K L L +L T+ + ++ + MD R +D ++ + +V
Sbjct: 227 LSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEV- 285
Query: 345 QQRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSI---NE 401
+ E++ R + +A T E + Q GD + T + I ++
Sbjct: 286 -RARYEEI----------ARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQ 334
Query: 402 EMQRMLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKD 461
E+QR+ +Q E +Q SL+ I D
Sbjct: 335 EIQRLQSQ-----------------------------------TENLKKQNASLQAAITD 359
Query: 462 TESLFKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQ 521
E + K+ Q +D++E L AK ++ R L EY E+ S K LDV++ T RRL+
Sbjct: 360 AEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEG 419
Query: 522 SGDRKSPAFTA 532
R S T+
Sbjct: 420 EECRMSGECTS 430
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 76.6 bits (187), Expect = 5e-14
Identities = 76/312 (24%), Positives = 134/312 (42%), Gaps = 49/312 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+++IT E L L ++ +++K R+E+E R ++ L+++ A + E
Sbjct: 210 QLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVE 269
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ + LS+L T++ + ++ + MD R +D+ + + +V Q
Sbjct: 270 LEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQY-- 327
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
ED+ + +A T E + GD+ +T I+E M RM+ +
Sbjct: 328 EDI----------ANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISE-MNRMIQR 376
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR A ++ +Q SL+ I D E +
Sbjct: 377 LR-------------------------------AEIDSVKKQCSSLQTAIADAEQRGELA 405
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI-----TQSGD 524
K+ + + +E L AK DM R L EY E+ ++K LDV++ T R+L+ SG+
Sbjct: 406 LKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGE 465
Query: 525 RKSPAFTAVPLS 536
SP +V S
Sbjct: 466 GVSPVNISVVTS 477
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/38 (39%), Positives = 25/38 (65%)
Query: 77 LKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQ 114
+KTLN +F F+ KV LE++N++LE + E+G +
Sbjct: 153 IKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSR 190
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 74.7 bits (182), Expect = 2e-13
Identities = 65/292 (22%), Positives = 129/292 (44%), Gaps = 48/292 (16%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q++T+ E L L ++ +++K ++E+E R ++++ ++++ EA + E
Sbjct: 150 QLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVE 209
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L ++E L E+ + L + EL ++I + ++ + MD R +D+ + + +V Q
Sbjct: 210 LESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQY-- 267
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
ED+ + S +E+E Q +E +S A ++++R +
Sbjct: 268 EDIA---------------------NRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTE 306
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQG--EQEDSLEKVIKDTESLFK 467
+ E + + AE +G Q SLE I D E +
Sbjct: 307 ISEMN-----------------------RNISRLQAEIEGLKGQRASLEAAIADAEQRGE 343
Query: 468 TREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + ++E L AK DM R L EY E+ ++K LD+++ T R+L+
Sbjct: 344 LAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLL 395
Score = 30.8 bits (68), Expect = 3.4
Identities = 16/43 (37%), Positives = 27/43 (62%), Gaps = 1/43 (2%)
Query: 77 LKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGL 119
+KTLN +F F+ KV LE++N++LE + L++ K R +
Sbjct: 95 IKTLNNKFASFIDKVRFLEQQNKMLETK-WSLLQQQKTARSNM 136
>gi|148612803 keratin 6 irs4 [Homo sapiens]
Length = 529
Score = 73.9 bits (180), Expect = 4e-13
Identities = 68/290 (23%), Positives = 131/290 (45%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q++T++ + L + L ++ ++YK+R+E E R ++ L+++A A A + E
Sbjct: 201 QLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVE 260
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ K L ++++ T E ++ + MD R +D+ + + +V + +
Sbjct: 261 LQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEV--RMHY 318
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ K + +A T + E + GD+ + T S E+ R++ +
Sbjct: 319 EEI----------ALKSKAEAEALYQTKIQELQLAASRHGDDLKHTR-SEMVELNRLIQR 367
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
+R C+ + +Q SLE I D E
Sbjct: 368 IR-------CEIGNVK------------------------KQRASLETAIADAEQRGDNA 396
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ Q +D++E L AK ++ R L EY E+ S+K LD+++ T R+L+
Sbjct: 397 LKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLL 446
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 72.0 bits (175), Expect = 1e-12
Identities = 68/290 (23%), Positives = 123/290 (42%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+D+I E L + L ++ +++K ++E+E R ++ L+++ A + E
Sbjct: 229 QLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVE 288
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ K LS++ T + + ++ + MD R +D+ + + +V
Sbjct: 289 LEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKA---- 344
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
Q + R R +A T E + GD+ +T I+ EM RM+ +
Sbjct: 345 -------QYEEIANRSR-TEAESWYQTKYEELQQTAGRHGDDLRNTKHEIS-EMNRMIQR 395
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR A + +Q +L+ I D E +
Sbjct: 396 LR-------------------------------AEIDNVKKQCANLQNAIADAEQRGELA 424
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + + ++E L AK DM R L EY E+ + K LDV++ T R+L+
Sbjct: 425 LKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLL 474
Score = 33.5 bits (75), Expect = 0.53
Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 10/92 (10%)
Query: 28 GGDHFAGGGDLPPAPLSPAGPA-------AYSPPGPGPAPPAAMALRNDLGSNINVLKTL 80
GG F GG P P+ P G + P P+ +R + I KTL
Sbjct: 119 GGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQI---KTL 175
Query: 81 NLRFRCFLAKVHELERRNRLLEKQLQQALEEG 112
N +F F+ KV LE++N++L+ + E+G
Sbjct: 176 NNKFASFIDKVRFLEQQNKVLDTKWTLLQEQG 207
Score = 30.8 bits (68), Expect = 3.4
Identities = 57/314 (18%), Positives = 128/314 (40%), Gaps = 49/314 (15%)
Query: 216 GPGLSWVHPDG---VGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDR 272
GPG P G V V +TP + + +V+ E E + ++ I D+
Sbjct: 129 GPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFI---DK 185
Query: 273 VNELQEEAQEADA----CQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDM 328
V L+++ + D QE+ V Q L F+ ++N +LD+ + E+
Sbjct: 186 VRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPL--FEQYINNLRRQLDSIVGERG----- 238
Query: 329 DICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPD 388
R+D ++ RN +D+++ F K + + + + T+ + D
Sbjct: 239 ----RLD--------SELRNMQDLVEDF--------KNKYEDEINKRTTAENEFVMLKKD 278
Query: 389 GDEEESTALSINEEMQRMLNQLR--EYDFEDDCDSLTWEETEETLLLWEDFS---GYAMA 443
D + + ++ +++++ + F+ + + ++ +++L D +
Sbjct: 279 VDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSI 338
Query: 444 AAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCS 503
AE + + E+ + + ES ++T+ +E Q+T + +L K HE EM
Sbjct: 339 IAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTK-------HEISEMNR 391
Query: 504 MKRGLDVQMETCRR 517
M + L +++ ++
Sbjct: 392 MIQRLRAEIDNVKK 405
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/289 (22%), Positives = 127/289 (43%), Gaps = 44/289 (15%)
Query: 231 IDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEEL 290
+D I E L + L ++ +++K+++E+E R ++ L+++ A + EL
Sbjct: 262 LDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVEL 321
Query: 291 ALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCE 350
KV+ L E+ + L LS++ + I + ++ + MD R +D+ + + +V Q E
Sbjct: 322 QAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQ--YE 379
Query: 351 DMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQL 410
D+ Q + + +A T L E + GD+ +T I E+ RM+ +L
Sbjct: 380 DIAQ----------RSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEI-IELNRMIQRL 428
Query: 411 REYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTRE 470
R A E +Q +L+ I + E +
Sbjct: 429 R-------------------------------AEIEGVKKQNANLQTAIAEAEQHGEMAL 457
Query: 471 KEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + +++ L AK+D+ R L +Y E+ ++K LDV++ T R+L+
Sbjct: 458 KDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLL 506
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 71.2 bits (173), Expect = 2e-12
Identities = 70/294 (23%), Positives = 132/294 (44%), Gaps = 52/294 (17%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+DT+ + L + L ++ +++K ++EEE R ++ L+++ A + E
Sbjct: 272 QLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVE 331
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ K L LS++ T + + ++ + MD R +D+ + + +V Q
Sbjct: 332 LEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQ--Y 389
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ Q + + +A T + + + GD ++T I E+ RM+ +
Sbjct: 390 EEIAQ----------RSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEI-AELNRMIQR 438
Query: 410 LRE--YDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFK 467
LR + + C +L ++A AE +G E +KD S
Sbjct: 439 LRAEIENIKKQCQTLQ----------------VSVADAEQRG------ENALKDAHS--- 473
Query: 468 TREKEYQETIDQIELE--LATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
++ELE L AK ++ R L EY E+ S+K LD+++ T R+L+
Sbjct: 474 ----------KRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLL 517
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 70.5 bits (171), Expect = 4e-12
Identities = 66/305 (21%), Positives = 130/305 (42%), Gaps = 59/305 (19%)
Query: 235 TPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKV 294
T E +AL ++ + R+EEE R + R+ E ++ A EA + EL ++
Sbjct: 154 TNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRI 213
Query: 295 EQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQ------RN 348
+ L E+ K + ++EL +IQ + V+MD+ + D++A L D+ Q +N
Sbjct: 214 DSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAALKDIRAQYEKLAAKN 272
Query: 349 CEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLN 408
++ + F+ + V +++ ++ R + ES L + ++
Sbjct: 273 MQNAEEWFK----------SRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLE---- 318
Query: 409 QLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKT 468
EA ++LEK +++ E
Sbjct: 319 ------------------------------------IEACRGMNEALEKQLQELEDKQNA 342
Query: 469 REKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSP 528
Q+TI+++E EL T K++M R+L EY ++ ++K LD+++ R+L+ G+
Sbjct: 343 DISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLL--EGEETRL 400
Query: 529 AFTAV 533
+FT+V
Sbjct: 401 SFTSV 405
Score = 35.4 bits (80), Expect = 0.14
Identities = 20/45 (44%), Positives = 29/45 (64%), Gaps = 4/45 (8%)
Query: 65 ALRNDLGS----NINVLKTLNLRFRCFLAKVHELERRNRLLEKQL 105
A+ NDL S L+ LN RF F+ +VHELE++N++LE +L
Sbjct: 78 AISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAEL 122
>gi|28372503 keratin 72 isoform 1 [Homo sapiens]
Length = 511
Score = 70.1 bits (170), Expect = 5e-12
Identities = 68/302 (22%), Positives = 132/302 (43%), Gaps = 54/302 (17%)
Query: 226 GVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADA 285
G GV++D+ E+R + +++ ++YK+R+E E R ++ L+++ A
Sbjct: 192 GDGVRLDS---ELRNMQDLV-------EDYKKRYEVEINRRTAAENEFVVLKKDVDAAYM 241
Query: 286 CQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQ 345
+ EL KV+ L E+ FK L ++++ + I + ++ + MD R +D+ + + +V
Sbjct: 242 NKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVRA 301
Query: 346 QRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQR 405
Q E++ K + +A T + E + GD+ + T I+ E+ R
Sbjct: 302 Q--YEEI----------ALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEIS-ELNR 348
Query: 406 MLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESL 465
++ ++R + A+ LE I D E
Sbjct: 349 LIQRIR-----------------------SEIGNVKKQCAD--------LETAIADAEQR 377
Query: 466 FKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDR 525
K+ + +D++E L AK ++ R L EY E+ S+K LD+++ T R+L+ R
Sbjct: 378 GDCALKDARAKLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECR 437
Query: 526 KS 527
S
Sbjct: 438 MS 439
>gi|226246663 keratin 72 isoform 1 [Homo sapiens]
Length = 511
Score = 70.1 bits (170), Expect = 5e-12
Identities = 68/302 (22%), Positives = 132/302 (43%), Gaps = 54/302 (17%)
Query: 226 GVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADA 285
G GV++D+ E+R + +++ ++YK+R+E E R ++ L+++ A
Sbjct: 192 GDGVRLDS---ELRNMQDLV-------EDYKKRYEVEINRRTAAENEFVVLKKDVDAAYM 241
Query: 286 CQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQ 345
+ EL KV+ L E+ FK L ++++ + I + ++ + MD R +D+ + + +V
Sbjct: 242 NKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVRA 301
Query: 346 QRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQR 405
Q E++ K + +A T + E + GD+ + T I+ E+ R
Sbjct: 302 Q--YEEI----------ALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEIS-ELNR 348
Query: 406 MLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESL 465
++ ++R + A+ LE I D E
Sbjct: 349 LIQRIR-----------------------SEIGNVKKQCAD--------LETAIADAEQR 377
Query: 466 FKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDR 525
K+ + +D++E L AK ++ R L EY E+ S+K LD+++ T R+L+ R
Sbjct: 378 GDCALKDARAKLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECR 437
Query: 526 KS 527
S
Sbjct: 438 MS 439
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 70.1 bits (170), Expect = 5e-12
Identities = 72/325 (22%), Positives = 125/325 (38%), Gaps = 66/325 (20%)
Query: 232 DTITPEIRALYNVLAKVKRERDEY--------------KRRWEEEYTVRIQLQDRVNELQ 277
D EIR L L V E+ + K R+EEE +R + + L+
Sbjct: 148 DAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALR 207
Query: 278 EEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDIT 337
++ +EA + EL KV+ L+ E+ + +++L +IQ + V+ + DI+
Sbjct: 208 KDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267
Query: 338 AKLCDVAQQRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTAL 397
L ++ Q M Q + + L+E+ ++ +
Sbjct: 268 TALKEIRSQLESHSDQNMHQAEEWFKCRYAK---------LTEA-------AEQNKEAIR 311
Query: 398 SINEEMQRMLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEK 457
S EE+ QL+ E E+ ++SLE+
Sbjct: 312 SAKEEIAEYRRQLQSKSIE----------------------------LESVRGTKESLER 343
Query: 458 VIKDTESLFKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRR 517
+ D E YQ+TI Q+E EL K +M RHL EY ++ ++K LD+++ R+
Sbjct: 344 QLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRK 403
Query: 518 LI--------TQSGDRKSPAFTAVP 534
L+ T +G P +T P
Sbjct: 404 LLEGEETRFSTFAGSITGPLYTHRP 428
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 69.3 bits (168), Expect = 9e-12
Identities = 90/391 (23%), Positives = 168/391 (42%), Gaps = 34/391 (8%)
Query: 156 LGSPARSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLV- 214
LGSP SP P A + SSSS ++ S G + S A RLG P+
Sbjct: 26 LGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGGLGSL-RASRLGTTRTPSSYG 84
Query: 215 QGPGLSWVHPDGVGVQIDTITP----EIRAL----YNVLAKVKRERDEYKRRWEEEYTVR 266
G L + D V + T E++ L N + KV+ + E ++
Sbjct: 85 AGELLDFSLADAVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLK 144
Query: 267 IQLQDRVNELQEEAQEADACQEELALKVEQL---KAELVVFKGLMSNNLSELDTKIQEK- 322
+ RV EL EE EL +VE L +A + V + + ++L L K+QE+
Sbjct: 145 GREPTRVAELYEEE------LRELRRQVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEI 198
Query: 323 -----------AMKVDMDIC--RRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRERK 369
A + D+D RID+ ++ + ++ + ++ + + +E++
Sbjct: 199 QLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQ 258
Query: 370 AAVEEDTSLSE-SEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSLTWEETE 428
VE D S + + R E A +I+E + +++ + + ++ + +
Sbjct: 259 VQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAK 318
Query: 429 ETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAK 488
+ ++ + +A DSL + +++ E F + YQ+ I ++E E+ K
Sbjct: 319 QEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLK 378
Query: 489 NDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
++M RHL EY ++ ++K LDV++ T R+L+
Sbjct: 379 DEMARHLREYQDLLNVKMALDVEIATYRKLL 409
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 68.2 bits (165), Expect = 2e-11
Identities = 60/287 (20%), Positives = 124/287 (43%), Gaps = 52/287 (18%)
Query: 246 AKVKRERDEY-------KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLK 298
A+++ ERD +++ ++E +R++ ++ + ++EA EA + +L K+E L+
Sbjct: 135 ARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194
Query: 299 AELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQV 358
E+ + + + EL ++ + + V++D+ + D+TA L ++
Sbjct: 195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEI--------------- 238
Query: 359 PSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDD 418
R + A+ E R D ++ A N E+ R D+
Sbjct: 239 -------RTQYEAMASSNMHEAEEWYRSKFADLTDAAAR--NAELLRQAKH-EANDYRRQ 288
Query: 419 CDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETID 478
SLT + E+ +SLE+ +++ E YQE +
Sbjct: 289 LQSLTCD-------------------LESLRGTNESLERQMREQEERHVREAASYQEALA 329
Query: 479 QIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDR 525
++E E + K++M RHL EY ++ ++K LD+++ T R+L+ +R
Sbjct: 330 RLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 376
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 68.2 bits (165), Expect = 2e-11
Identities = 60/287 (20%), Positives = 124/287 (43%), Gaps = 52/287 (18%)
Query: 246 AKVKRERDEY-------KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLK 298
A+++ ERD +++ ++E +R++ ++ + ++EA EA + +L K+E L+
Sbjct: 135 ARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194
Query: 299 AELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQV 358
E+ + + + EL ++ + + V++D+ + D+TA L ++
Sbjct: 195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEI--------------- 238
Query: 359 PSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDD 418
R + A+ E R D ++ A N E+ R D+
Sbjct: 239 -------RTQYEAMASSNMHEAEEWYRSKFADLTDAAAR--NAELLRQAKH-EANDYRRQ 288
Query: 419 CDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETID 478
SLT + E+ +SLE+ +++ E YQE +
Sbjct: 289 LQSLTCD-------------------LESLRGTNESLERQMREQEERHVREAASYQEALA 329
Query: 479 QIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDR 525
++E E + K++M RHL EY ++ ++K LD+++ T R+L+ +R
Sbjct: 330 RLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 376
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 67.8 bits (164), Expect = 3e-11
Identities = 66/290 (22%), Positives = 124/290 (42%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+D+I E L + L ++ ++ K ++E+E R ++ L+++ A + E
Sbjct: 224 QLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVE 283
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L K + L E+ + L LS++ T I + ++ + MD R +D+ + + +V Q
Sbjct: 284 LQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQ--Y 341
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ Q + +A T E + GD+ +T I E+ RM+ +
Sbjct: 342 EEIAQ----------RSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEI-AEINRMIQR 390
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR + + +Q SL+ I D E +
Sbjct: 391 LR-------------------------------SEIDHVKKQCASLQAAIADAEQRGEMA 419
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + ++ +E L AK D+ R L EY E+ ++K LDV++ T R+L+
Sbjct: 420 LKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLL 469
Score = 34.3 bits (77), Expect = 0.31
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 28 GGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAM----ALRNDLGSNINVLKTLNLR 83
GG AGG P P+ P G P + A++ +KTLN +
Sbjct: 114 GGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNK 173
Query: 84 FRCFLAKVHELERRNRLLEKQLQQALEEG 112
F F+ KV LE++N++L+ + E+G
Sbjct: 174 FASFIDKVRFLEQQNKVLDTKWTLLQEQG 202
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 67.8 bits (164), Expect = 3e-11
Identities = 63/290 (21%), Positives = 126/290 (43%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+D++ E L L ++ +++K+++E+E R ++ L+++ A + E
Sbjct: 244 QLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVE 303
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L KV+ L E+ + L LS++ + + ++ + MD R +D+ + + +V Q
Sbjct: 304 LQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQ--Y 361
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ Q + + +A T L E + GD+ +T I E+ RM+ +
Sbjct: 362 EEIAQ----------RSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEI-MELNRMIQR 410
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR A E +Q +L+ I + E +
Sbjct: 411 LR-------------------------------AEIENVKKQNANLQTAIAEAEQRGEMA 439
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + ++ L AK+D+ R L +Y E+ ++K LDV++ T R+L+
Sbjct: 440 LKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLL 489
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 67.4 bits (163), Expect = 3e-11
Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 53/293 (18%)
Query: 229 VQID--TITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADAC 286
+Q+D + E+R++ +V+ +++K ++E+E R ++ L+++ A
Sbjct: 155 LQVDGGRLEAELRSMQDVV-------EDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMS 207
Query: 287 QEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQ 346
+ EL KV+ L E+ + L L+EL ++I + ++ + MD R +D+ + +V Q
Sbjct: 208 KVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQ 267
Query: 347 RNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRM 406
E+M + + +A T + GD+ +T I+ EM R
Sbjct: 268 --YEEMAKCSRA----------EAEAWYQTKFETLQAQAGKHGDDLRNTRNEIS-EMNRA 314
Query: 407 LNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLF 466
+ +L+ A + Q LE I + E
Sbjct: 315 IQRLQ-------------------------------AEIDNIKNQRAKLEAAIAEAEERG 343
Query: 467 KTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
+ K+ + +++E L K DM R L EY E+ S+K LD+++ T R+L+
Sbjct: 344 ELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLL 396
Score = 32.7 bits (73), Expect = 0.90
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 5/60 (8%)
Query: 59 APPAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQ--LQQALEEGKQGR 116
A P+ +R + I KTLN +F F+ KV LE++N+LLE + L Q + K R
Sbjct: 80 ADPSLQRVRQEESEQI---KTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSR 136
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 67.4 bits (163), Expect = 3e-11
Identities = 65/290 (22%), Positives = 125/290 (43%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+D+I E L + L ++ +++K ++E+E R ++ L+++ A + E
Sbjct: 224 QLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVE 283
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L K + L E+ + L LS++ T I + ++ + MD R +D+ + + +V Q
Sbjct: 284 LQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQ--Y 341
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ Q + +A T E + GD+ +T I E+ RM+ +
Sbjct: 342 EEIAQ----------RSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEI-AEINRMIQR 390
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR + + +Q +L+ I D E +
Sbjct: 391 LR-------------------------------SEIDHVKKQCANLQAAIADAEQRGEMA 419
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + ++ +E L AK D+ R L EY E+ ++K LDV++ T R+L+
Sbjct: 420 LKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLL 469
Score = 33.9 bits (76), Expect = 0.40
Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 28 GGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAMALRNDL----GSNINVLKTLNLR 83
GG AGG P P+ P G P + + + +KTLN +
Sbjct: 114 GGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNK 173
Query: 84 FRCFLAKVHELERRNRLLEKQLQQALEEG 112
F F+ KV LE++N++LE + E+G
Sbjct: 174 FASFIDKVRFLEQQNKVLETKWTLLQEQG 202
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 65.9 bits (159), Expect = 1e-10
Identities = 61/298 (20%), Positives = 130/298 (43%), Gaps = 44/298 (14%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
++D + + L + L ++ ++Y+ ++E+E R ++ ++++ A + +
Sbjct: 241 RVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVD 300
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L K++ L+ E+ L LS++ T+I E + + MD R +D+ + + +V Q
Sbjct: 301 LQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQ--Y 358
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
ED+ Q K + +A + E + GD ++ + I+ E+ R++ +
Sbjct: 359 EDIAQ----------KSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEIS-ELNRVIQR 407
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR + D++ +Q +L++ I D E +
Sbjct: 408 LR-----SEIDNVK--------------------------KQISNLQQSISDAEQRGENA 436
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKS 527
K+ + ++ +E L AK D+ R L +Y E+ + K LD+++ T R L+ R S
Sbjct: 437 LKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMS 494
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 65.9 bits (159), Expect = 1e-10
Identities = 65/290 (22%), Positives = 123/290 (42%), Gaps = 44/290 (15%)
Query: 230 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEE 289
Q+D I E L + L ++ ++ K ++E+E R ++ L+++ A + E
Sbjct: 224 QLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVE 283
Query: 290 LALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNC 349
L K + L E+ + L LS++ T I + ++ + MD R +D+ + + +V Q
Sbjct: 284 LQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQ--Y 341
Query: 350 EDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQ 409
E++ Q + +A T E + GD+ +T I E+ RM+ +
Sbjct: 342 EEIAQ----------RSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEI-AEINRMIQR 390
Query: 410 LREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTR 469
LR + + +Q +L+ I D E +
Sbjct: 391 LR-------------------------------SEIDHVKKQCANLQAAIADAEQRGEMA 419
Query: 470 EKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLI 519
K+ + ++ +E L AK D+ R L EY E+ ++K LDV++ T R+L+
Sbjct: 420 LKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLL 469
Score = 34.3 bits (77), Expect = 0.31
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 28 GGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAM----ALRNDLGSNINVLKTLNLR 83
GG AGG P P+ P G P + A++ +KTLN +
Sbjct: 114 GGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNK 173
Query: 84 FRCFLAKVHELERRNRLLEKQLQQALEEG 112
F F+ KV LE++N++L+ + E+G
Sbjct: 174 FASFIDKVRFLEQQNKVLDTKWTLLQEQG 202
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 63.5 bits (153), Expect = 5e-10
Identities = 59/281 (20%), Positives = 119/281 (42%), Gaps = 46/281 (16%)
Query: 249 KRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVFKGLM 308
K D+++ ++E E ++R ++ +N L+ E C+ +L +VE LK EL+ K
Sbjct: 135 KLASDDFRTKYETELSLRQLVESDINGLRRILDELTLCRSDLEAQVESLKEELLCLKQNH 194
Query: 309 SNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRER 368
++ L ++ ++ + V++D +D+ L + Q
Sbjct: 195 EQEVNTLRCQLGDR-LNVEVDAAPTVDLNQVLNETRSQY--------------------- 232
Query: 369 KAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSLTWEETE 428
+A VE + E Q + +N+++ QL+ Y E + T
Sbjct: 233 EALVETNRREVEQWFATQTE---------ELNKQVVSSSEQLQSYQAE----IIELRRTV 279
Query: 429 ETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAK 488
L + +AQ DSLE + ++E+ + ++ + Q I +E +LA +
Sbjct: 280 NALEI----------ELQAQHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIR 329
Query: 489 NDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPA 529
+D+ R EY + ++ L+ ++ T R L+ +S D K P+
Sbjct: 330 SDLERQNQEYQVLLDVRARLECEINTYRSLL-ESEDCKLPS 369
>gi|125628636 keratin 80 isoform a [Homo sapiens]
Length = 452
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/292 (22%), Positives = 130/292 (44%), Gaps = 49/292 (16%)
Query: 245 LAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVF 304
L +V + +E++ R+E+E + R ++ +L+++ + EL K++ L++ + +
Sbjct: 157 LLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELM 216
Query: 305 KGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGR 364
K + L +L ++++ ++ V MD ID++ + +V Q + + + +
Sbjct: 217 KTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRS 276
Query: 365 KRERKAA--VEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSL 422
+ E +AA E +SL S S +N +Q++ +Q+ + C L
Sbjct: 277 QLEEQAARSAEYGSSLQSSR-----------SEIADLNVRIQKLRSQI--LSVKSHC--L 321
Query: 423 TWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIEL 482
EE +T AE QGE +D ++ + Q+E
Sbjct: 322 KLEENIKT--------------AEEQGEL------AFQDAKT-----------KLAQLEA 350
Query: 483 ELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLIT-QSGDRKSPAFTAV 533
L AK DM R L +Y E+ ++K LD+++ T R+L+ + G SP+ T V
Sbjct: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVV 402
Score = 30.4 bits (67), Expect = 4.5
Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 3/42 (7%)
Query: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLE 102
PA L+N +K LN +F + KV LE+RN+LLE
Sbjct: 74 PAVQQLKNQEKEE---MKALNDKFASLIGKVQALEQRNQLLE 112
>gi|125628632 keratin 80 isoform b [Homo sapiens]
Length = 422
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/292 (22%), Positives = 130/292 (44%), Gaps = 49/292 (16%)
Query: 245 LAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVF 304
L +V + +E++ R+E+E + R ++ +L+++ + EL K++ L++ + +
Sbjct: 157 LLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELM 216
Query: 305 KGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGR 364
K + L +L ++++ ++ V MD ID++ + +V Q + + + +
Sbjct: 217 KTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRS 276
Query: 365 KRERKAA--VEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSL 422
+ E +AA E +SL S S +N +Q++ +Q+ + C L
Sbjct: 277 QLEEQAARSAEYGSSLQSSR-----------SEIADLNVRIQKLRSQI--LSVKSHC--L 321
Query: 423 TWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIEL 482
EE +T AE QGE +D ++ + Q+E
Sbjct: 322 KLEENIKT--------------AEEQGEL------AFQDAKT-----------KLAQLEA 350
Query: 483 ELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLIT-QSGDRKSPAFTAV 533
L AK DM R L +Y E+ ++K LD+++ T R+L+ + G SP+ T V
Sbjct: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVV 402
Score = 30.4 bits (67), Expect = 4.5
Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 3/42 (7%)
Query: 61 PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLE 102
PA L+N +K LN +F + KV LE+RN+LLE
Sbjct: 74 PAVQQLKNQEKEE---MKALNDKFASLIGKVQALEQRNQLLE 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,407,060
Number of Sequences: 37866
Number of extensions: 1326167
Number of successful extensions: 16572
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 546
Number of HSP's that attempted gapping in prelim test: 13256
Number of HSP's gapped (non-prelim): 3467
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.