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Search of human proteins with 16933559
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16933559 protocadherin LKC precursor [Homo sapiens]
(1310 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16933559 protocadherin LKC precursor [Homo sapiens] 2578 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 323 9e-88
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 267 6e-71
gi|16933565 protocadherin 21 precursor [Homo sapiens] 264 5e-70
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 254 4e-67
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 237 5e-62
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 232 2e-60
gi|16933557 dachsous 1 precursor [Homo sapiens] 223 7e-58
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 214 3e-55
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 214 6e-55
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens] 213 1e-54
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 210 8e-54
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 202 1e-51
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 177 6e-44
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 177 6e-44
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 177 6e-44
gi|14589929 protocadherin 18 precursor [Homo sapiens] 174 5e-43
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 172 1e-42
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 172 1e-42
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 172 1e-42
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 172 1e-42
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 172 2e-42
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 172 2e-42
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 172 2e-42
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 171 4e-42
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 171 4e-42
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 171 4e-42
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 171 4e-42
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 171 4e-42
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 171 4e-42
>gi|16933559 protocadherin LKC precursor [Homo sapiens]
Length = 1310
Score = 2578 bits (6683), Expect = 0.0
Identities = 1310/1310 (100%), Positives = 1310/1310 (100%)
Query: 1 MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTY 60
MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTY
Sbjct: 1 MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTY 60
Query: 61 GMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDN 120
GMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDN
Sbjct: 61 GMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDN 120
Query: 121 APVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRIL 180
APVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRIL
Sbjct: 121 APVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRIL 180
Query: 181 ANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQ 240
ANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQ
Sbjct: 181 ANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQ 240
Query: 241 FVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVN 300
FVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVN
Sbjct: 241 FVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVN 300
Query: 301 GSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPA 360
GSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPA
Sbjct: 301 GSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPA 360
Query: 361 CTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSP 420
CTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSP
Sbjct: 361 CTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSP 420
Query: 421 ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTF 480
ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTF
Sbjct: 421 ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTF 480
Query: 481 PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV 540
PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV
Sbjct: 481 PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV 540
Query: 541 RNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGN 600
RNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGN
Sbjct: 541 RNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGN 600
Query: 601 VSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGR 660
VSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGR
Sbjct: 601 VSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGR 660
Query: 661 IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWD 720
IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWD
Sbjct: 661 IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWD 720
Query: 721 ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780
ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA
Sbjct: 721 ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780
Query: 781 ENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA 840
ENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA
Sbjct: 781 ENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA 840
Query: 841 QLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLA 900
QLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLA
Sbjct: 841 QLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLA 900
Query: 901 TDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGN 960
TDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGN
Sbjct: 901 TDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGN 960
Query: 961 NGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020
NGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV
Sbjct: 961 NGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020
Query: 1021 QARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVY 1080
QARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVY
Sbjct: 1021 QARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVY 1080
Query: 1081 IVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGS 1140
IVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGS
Sbjct: 1081 IVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGS 1140
Query: 1141 QESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAG 1200
QESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAG
Sbjct: 1141 QESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAG 1200
Query: 1201 VMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNS 1260
VMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNS
Sbjct: 1201 VMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNS 1260
Query: 1261 QEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL 1310
QEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL
Sbjct: 1261 QEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL 1310
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 323 bits (827), Expect = 9e-88
Identities = 307/1029 (29%), Positives = 474/1029 (46%), Gaps = 94/1029 (9%)
Query: 31 TSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYET 89
T +++ ED PVG+ L+A+D DNDPL +G+SG A FFAV P TG V L LD ET
Sbjct: 38 TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
Query: 90 LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149
F V SVSD + R++ + V D NDNAP F N +S I E PVG+ +F V A
Sbjct: 98 KSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 150 DKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDL 209
D D+G+ G V+YS + S+ A G + + L Y A YQL + A D
Sbjct: 158 DPDLGAGGSVLYSFQP------PSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATD- 209
Query: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
T S L+I + D D+DP F+ YS ++ E + GT+V + A+D D
Sbjct: 210 -----QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
Query: 270 KGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNI 328
KG + Y+I F + GV+ +NG LDRE L + + L V TE + +
Sbjct: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
Query: 329 YGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDD 388
+A V+ + V+D+ND+ PEF N S + T E AQV F +P+
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEF-NSSEYSVAIT-ELAQVGFA----------LPL-F 370
Query: 389 LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMA 448
+ +V D + G N F + L G ++ F +SP G A ++ +RV+ +DYE
Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR--IRVAIPLDYETVDRYD 428
Query: 449 VQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDP 508
+ A +SV + A V I L + ND+RP F Q LY +++ E+ G+ V ++ ATD
Sbjct: 429 FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL-TVLATDN 487
Query: 509 DTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSS 568
D G +G+++Y + D F +D +G + + LD E + LT+ A DGG +
Sbjct: 488 DAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLI--ARLDYELIQRFTLTIIARDGGGEET 543
Query: 569 STTLQIHLLDINDNAPVV-SGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLP- 626
+ ++I++LD+NDN P +Y ++E E +V+ ++ DE N+++ ++++
Sbjct: 544 TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
Query: 627 ---GPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTI 683
G Y + SL G++ PLD E I G I LTV+ D G P L + V VTI
Sbjct: 604 SAFGSY-FDISLYEGYGVISVSRPLDYEQIS---NGLIYLTVMAMDAGNPPLNSTVPVTI 659
Query: 684 TVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYF 742
V D NDN P F++ +Y +V E G V + A D D++ + S S G+ F
Sbjct: 660 EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQF 719
Query: 743 MIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGET--IVDVCVNVKD 800
I +G + LD ET+ + L V A + + I V + + D
Sbjct: 720 RINA---RSG------EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLD 770
Query: 801 VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGS 860
+NDN PT A I + E V VVA D D + + +I + S
Sbjct: 771 INDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTL-VYSIQPPNKFYSLNS 828
Query: 861 LCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIED 920
+++ +EA + +VV D P +++ ++ + + D
Sbjct: 829 TT----GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP--LKATSSATVFVNLLD 882
Query: 921 VNDNAPYFLPENKTFVI-IPELVLPNREVASVRARDDDSGNNGVILF----SILRVDFIS 975
+NDN P F +N FV + E + + V A D D G NG++ + + R+DF+
Sbjct: 883 LNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 940
Query: 976 KDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEAT 1035
+G + T LD YQ+ V A D + P +T
Sbjct: 941 NSS--------------------SGVVVTTTELDRERIAEYQLRVVASDAGT--PTKSST 978
Query: 1036 TTLNLFTVD 1044
+TL + +D
Sbjct: 979 STLTIHVLD 987
Score = 229 bits (585), Expect = 1e-59
Identities = 282/1027 (27%), Positives = 441/1027 (42%), Gaps = 121/1027 (11%)
Query: 37 EDLPVGAQAFWLVAEDQDN-DPLTYGMSGPNAY-------FFAVTPKTGEVKLASALDYE 88
E+L +G + + A DN + +TY NAY F + TG + + +D E
Sbjct: 1324 ENLALGTEIVRVQAYSIDNLNQITYRF---NAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
Query: 89 T--LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFST-SINETLPVGSVVFS 145
YT V P + ++ + V D NDN+P F T+ S SI E PVG V +
Sbjct: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
Query: 146 VLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN----GSIVLNGSLSYNNKSAFYQ 201
V A D D GS G VV+S+ ++G+ F I+ G + + L + Y
Sbjct: 1441 VKAWDPDAGSNGQVVFSL-----ASGNIAGAFEIVTTNDSIGEVFVARPLD-REELDHYI 1494
Query: 202 LELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREF-YSASVAEDAAKGTSV 260
L++ A D G T L ++++D D P F Y+ SV E+ GT+V
Sbjct: 1495 LQVVASDRG-------TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
Query: 261 LTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSL-DREQLLEADEEVQLQV 319
+ V A D D GIN + Y I+ + F + R++G + R + + + +
Sbjct: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMD-----RISGEIATRPAPPDRERQSFYHL 1602
Query: 320 TATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEH 379
AT A ++VT+ +D ND+ P F Q ++ +DE
Sbjct: 1603 VATVEDEGTPTLSATTHVYVTI--VDENDNAPMFQ--------------QPHYEVLLDE- 1645
Query: 380 ASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSAL 438
+ +T+ D D+G NGT ++ G F + +A+ ++ +S
Sbjct: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEIS-- 1703
Query: 439 VDYERQTAMAVQVVATDSVSQNF-SVAMVTIHLRDINDHRPTFPQSLY-VLTVPEHSATG 496
+ R T + +S S V +++ DIND+ PTFP+ V E
Sbjct: 1704 --HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
Query: 497 SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
V T H D D+G GQ+ YS++ G+ F + PV G + VR LDRE+ A Y L
Sbjct: 1762 RVWTFLAH--DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
Query: 557 TLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQEEEGNVSVTIQAHDNDEP 613
T+ A D G LSS+ + I +LDINDN PV+ NI + E S +D
Sbjct: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
Query: 614 GTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE- 672
N+RL FN+ G F ++ TG++ PLDRE I LT+ V D E
Sbjct: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP-----EYKLTISVKDNPEN 1934
Query: 673 PVLGTKVN--VTITVEDINDNLPIFNQSSYNFTVKEEDPG-----VLVGVVKAWDADQTE 725
P + + + I + D NDN P+F +S+Y V E P VL G + A DADQ +
Sbjct: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ-D 1993
Query: 726 ANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYE--TQPVFNLTVSAENP 783
+++ L G+ + F I + G + + V +D E + P+ L + AE
Sbjct: 1994 IYAVVTYQLLGAQSGLFDINS-------STGVVTVRSGVIIDREAFSPPILELLLLAE-- 2044
Query: 784 DPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLE 843
D + + + + D NDN PT A+L + + EN V V A+D D+ E
Sbjct: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLT-VHLLENCPPGFSVLQVTATDEDSGLNGE 2103
Query: 844 IQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDP 903
+ + +AG L V G+ I++ + Y R +ATD
Sbjct: 2104 L----VYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESY----------RLTVVATDR 2149
Query: 904 GFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGV 963
G S + I I+D+ND+ P FL +T V + E P +A++ A D D N
Sbjct: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQT-VSVLESAEPGTVIANITAIDHDL--NPK 2206
Query: 964 ILFSILRVDFISKDGA--TIPFQ-GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020
+ + I V ++KD +P Q F++ ++ GS+ + ++ L TY+VT+
Sbjct: 2207 LEYHI--VGIVAKDDTDRLVPNQEDAFAV------NINTGSVMVKSPMNRELVATYEVTL 2258
Query: 1021 QARDRPS 1027
D S
Sbjct: 2259 SVIDNAS 2265
Score = 226 bits (576), Expect = 1e-58
Identities = 313/1247 (25%), Positives = 518/1247 (41%), Gaps = 172/1247 (13%)
Query: 48 LVAEDQDND---PLTYGMSGPNAYFFAVTPKTGEVKLASA--LDYETLYT--FKVTISVS 100
++A D D D +TY + G + F + TG V + S +D E ++ +
Sbjct: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
Query: 101 D-PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMV 159
D + +L+ + D NDN P F + + E P G V V A D+D G G +
Sbjct: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGEL 2104
Query: 160 VYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI 219
VY IE G + L G I + + + Y+L + A D G T+
Sbjct: 2105 VYRIE-----AGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG-------TV 2152
Query: 220 QCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS 279
S ++I + D D P+F+ + SV E A GT + + A+D D +N + Y
Sbjct: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
Query: 280 I--------SYSTRPGWFDIGA----DGVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327
I + P D A G + V ++RE L A EV L V + L
Sbjct: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE--LVATYEVTLSVIDNASDL- 2267
Query: 328 IYGQEAKVSI---WVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRI 384
E VS+ +TV V+DVND+ P+F + T+ E + E A+P
Sbjct: 2268 ---PERSVSVPNAKLTVNVLDVNDNTPQFKPFGI---TYYMER--------ILEGATPGT 2313
Query: 385 PIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQ 444
+ + + DPDKG NG +L + + +AG V + VDYE
Sbjct: 2314 TL--IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK------VIANRTVDYEEV 2365
Query: 445 TAMAVQVVATDSVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSI 503
+ V A+D+ S + + V + + DIND+ P F Q Y V E G+++ ++
Sbjct: 2366 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL-TV 2424
Query: 504 HATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDG 563
ATD D+G + I YSL G+G F ++P +G + V + LDRE + Y LT A D
Sbjct: 2425 TATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKDN 2480
Query: 564 -GNLSS-----STTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPG 614
G+++S S + I +LD+ND P S S +++ E G +T+ A D DE
Sbjct: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
Query: 615 TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV 674
N L ++L GP F +D D+GL+ PL + LTV+ +D GEP
Sbjct: 2541 --NGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQSYE-------KFSLTVVATDGGEPP 2590
Query: 675 LGTKVNVTITVEDINDNLPIFNQSSYN--FTVKEEDPGVLVGVVKAWDADQTEA-NNRIS 731
L + + V D+NDN P+F + ++EE P + V + + D+ E N +
Sbjct: 2591 LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP-LRSNVYEVYATDKDEGLNGAVR 2649
Query: 732 FSLSGSGAN----YFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT-VSAENPDPQ 786
+S + N +F+I + +G + RL D E+Q V++L V+++ P
Sbjct: 2650 YSFLKTAGNRDWEFFIIDPI---SGLIQTAQRL------DRESQAVYSLILVASDLGQPV 2700
Query: 787 GGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQL 846
ET+ + V ++D++DN P +R + Q+ + V S T L
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLF-------VRPPKGSPQYQLLTVPEHSPRGT-------L 2746
Query: 847 VNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF- 905
V + D G ++ +AA N+ K + D LV+R D + F
Sbjct: 2747 VGNVTGAVDADEGPNAIVYYFIAAG-----NEEKNFHLQP-DGCLLVLRDLDREREAIFS 2800
Query: 906 ---QAYSNNG--------------------SLLITIEDVNDNAPYFLPENKTFVIIPELV 942
+A SN + + +ED+ND P F T + +
Sbjct: 2801 FIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAK 2860
Query: 943 LPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI 1002
+ + E+ V A D D GNN ++ +SIL + + + V +FT D G +
Sbjct: 2861 VGS-ELIQVLALDADIGNNSLVFYSILAIHYFR--ALANDSEDVGQVFTMGSMD---GIL 2914
Query: 1003 QPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGA 1062
+ + G + V + ARD T + ++ + R ++ + + V
Sbjct: 2915 RTFDLFMAYSPGYFVVDIVARDLAGHND----TAIIGIYILRDDQRVKIVINEIPDRVRG 2970
Query: 1063 NRQAINAALTQATRTTVYIVDIQ-DIDSAARAR-PHSYLDAYFV-FPNGSALTLDELSVM 1119
+ L+ T V ++Q +D R + L + V L +D + M
Sbjct: 2971 FEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQM 3030
Query: 1120 IRNDQDSLTQLLQLGLVVLGSQES----QESDLSKQLISVIIGLGVALLLVLVIMTMAFV 1175
I +++ L L + VL Q + D+S +++I+ L + L L ++ +
Sbjct: 3031 IDENKEQLRNLFR-NYNVLDVQPAISVRLPDDMSALQMAIIV-LAILLFLAAMLFVLMNW 3088
Query: 1176 CVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPM 1222
R + RKL+A+ A + +M +P TN Y+ + ANP+
Sbjct: 3089 YYRTVHKRKLKAIVAGSAGNRGFIDIMD----MPNTNKYSFDGANPV 3131
Score = 224 bits (571), Expect = 4e-58
Identities = 282/1043 (27%), Positives = 437/1043 (41%), Gaps = 138/1043 (13%)
Query: 35 LPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVKLASAL------ 85
L E P + +VA D D N L Y + PN F+++ TG+++ A+
Sbjct: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENP 845
Query: 86 -DYETLYTFKVTISVSD---PYIQVQREMLVIVE--DRNDNAPVFQNTAFSTSINETLPV 139
+E K+ +SV+D P ++ V V D NDN P FQN F + E +P
Sbjct: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
Query: 140 GSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAF 199
G ++ V+A+D D G G+V Y + +P F I ++ +V+ + + A
Sbjct: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD-----FLINSSSGVVVTTTELDRERIAE 960
Query: 200 YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259
YQL + A D G T S L+I V+D D P F Y+ SV+ED +
Sbjct: 961 YQLRVVASDAG-------TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR 1013
Query: 260 VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQ------LLEAD 312
V+ + D D G+N + Y I+ G F +G D V+R LDRE +LEA
Sbjct: 1014 VVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAI 1073
Query: 313 EE--VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
+ V + T T T V V V+DVND++P F S A PE+
Sbjct: 1074 DNGPVGKRHTGTAT--------------VFVTVLDVNDNRPIFLQSSYEAS--VPEDIP- 1116
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASV 429
+ H+ L + D D+G G + L G F + S
Sbjct: 1117 ------EGHSI-------LQLKATDADEGEFGRVWYRILHGNHGNNFRI-------HVSN 1156
Query: 430 QVLVRVSALVDYERQTAMAVQVVA-TDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYV-L 487
+L+R +D ER ++ + V A + S V +++ DIND P F Q Y L
Sbjct: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRL 1216
Query: 488 TVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLD 547
+ E + G+ V + ATD D+G G + Y +L G F++D +G + N LD
Sbjct: 1217 GLRETAGIGTSVI-VVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLD 1272
Query: 548 RESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV---SGSYNIFVQEE--EGNVS 602
E++ Y + + ATD + +++ +N+ V + SY + E G
Sbjct: 1273 YETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI 1332
Query: 603 VTIQAHDNDEPGTNNSRLLFNLLPGPYSHN-FSLDPDTGLLRNLGPLDREAIDPALEGRI 661
V +QA+ D N FN + F +D TG++ G +DRE +G
Sbjct: 1333 VRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE------KGDF 1384
Query: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYN-FTVKEEDP-GVLVGVVKAW 719
+V+D G P + + V V ITV D NDN P F+ +S + ++ E+ P G V VKAW
Sbjct: 1385 YTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW 1444
Query: 720 DADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPD-VSLDYETQPVFNLT 777
D D +N ++ FSL SG+ A F I + E ++ P D LD+ + +
Sbjct: 1445 DPD-AGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFVARPLDREELDHY---ILQVV 1498
Query: 778 VSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
S P+ + I+ V + D+NDNPP ++ S G V+ N + G AVV D
Sbjct: 1499 ASDRGTPPRKKDHILQ--VTILDINDNPPVIE--SPFGYNVSVNENVGGGTAVVQVRATD 1554
Query: 838 TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRAC 897
+ +++ T+ D+ F + + D E LV
Sbjct: 1555 RDIGIN-SVLSYYITEGNKDMA------FRMDRISGEIATRPAPPDRERQSFYHLVA--- 1604
Query: 898 DLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDD 957
D G S + +TI D NDNAP F + ++ N + +++A D D
Sbjct: 1605 -TVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD 1663
Query: 958 SGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTL-QGTY 1016
G NG + ++I+ +I + D G I LD + G Y
Sbjct: 1664 EGPNGTVTYAIV----------------AGNIVNTFRIDRHMGVITAAKELDYEISHGRY 1707
Query: 1017 QVTVQARDR-PSLGPFLEATTTL 1038
+ V A D+ P L L +TTT+
Sbjct: 1708 TLIVTATDQCPILSHRLTSTTTV 1730
Score = 211 bits (538), Expect = 3e-54
Identities = 274/1076 (25%), Positives = 442/1076 (41%), Gaps = 142/1076 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDN------DPLTYGMSGPNAYFFAVTPKTG 77
P F V + E++ GA +L A D D + + Y + G F + ++G
Sbjct: 669 PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSG 726
Query: 78 EVKLASALDYETLYTFKVTISVSDPYIQVQRE-----MLVIVEDRNDNAPVFQNTAFSTS 132
E+ S LD ET + + + D + ++ + + + D NDN P +++ + +
Sbjct: 727 EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
Query: 133 INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLS 192
+ E P S V +V+AVD D+G G +VYSI+ + +I +++ +
Sbjct: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPD 846
Query: 193 YNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
+ ++ + D G S VF ++++D D DP F + A V E
Sbjct: 847 PHEAELMRKIVVSVTDCG---RPPLKATSSATVF--VNLLDLNDNDPTFQNLPFVAEVLE 901
Query: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYS-TRPGWFDIGADGVIRVNGSLDREQLLEA 311
G S+ V A+D D+G+N V Y + R + + GV+ LDRE++
Sbjct: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI--- 958
Query: 312 DEEVQLQVTATETHLNIYGQEAKVSI-WVTVRVMDVNDHKPEFYNC--SLPACTFTPEEA 368
E QL+V A++ G K S +T+ V+DVND P F+ ++ P E
Sbjct: 959 -AEYQLRVVASDA-----GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREF 1012
Query: 369 QVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG--TFLLSLGGPDAEAFSVSPERAAGS 426
+V + D D G N ++ ++ G D + FSV A
Sbjct: 1013 RVVWLNCTDN------------------DVGLNAELSYFITGGNVDGK-FSVGYRDA--- 1050
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDS---VSQNFSVAMVTIHLRDINDHRPTFPQS 483
+VR +D E A + + A D+ ++ A V + + D+ND+RP F QS
Sbjct: 1051 -----VVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQS 1105
Query: 484 LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNG 543
Y +VPE G + + ATD D G +G++ Y +L GN + F++ VS + +R
Sbjct: 1106 SYEASVPEDIPEGHSIL-QLKATDADEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGP 1163
Query: 544 ELLDRESQAVYYLTLQA--TDGGNLSSSTTLQIHLLDINDNAPV-VSGSYNIFVQEEEGN 600
LDRE + + L ++A D G + SS + +++ DIND APV Y+ E
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
Query: 601 VS---VTIQAHDND--EPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDP 655
+ + +QA D D + G N R+L F +D TGL+ + LD E
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGA-----EGKFEIDESTGLIITVNYLDYET--- 1275
Query: 656 ALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVG 714
+ ++ V +D P +V IT+ + D F+ +SY + E G +
Sbjct: 1276 --KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIV 1333
Query: 715 VVKAWDADQ-TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPV 773
V+A+ D + R + S F I + G +G +D E
Sbjct: 1334 RVQAYSIDNLNQITYRFNAYTSTQAKALFKI-DAITGVITVQGL--------VDREKGDF 1384
Query: 774 FNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVA 833
+ LTV A++ P+ T V V + V D NDN P D S + + E+ +VA V A
Sbjct: 1385 YTLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKA 1443
Query: 834 SDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSV-YINQSKAIDYEACDLVTL 892
D D + ++ + G++ + V N S+ + ++ +D E D L
Sbjct: 1444 WDPDAGSNGQVVF--------SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYIL 1495
Query: 893 VVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVR 952
V A D T P + L +TI D+NDN P V + E V V VR
Sbjct: 1496 QVVASDRGTPP----RKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
Query: 953 ARDDDSGNNGVILFSI--------LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQP 1004
A D D G N V+ + I R+D IS + AT P
Sbjct: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRP---------------------- 1589
Query: 1005 VTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEV 1060
D Q Y + D + P L ATT + + VD++ + + F P EV
Sbjct: 1590 -APPDRERQSFYHLVATVEDEGT--PTLSATTHVYVTIVDENDNAPM-FQQPHYEV 1641
Score = 211 bits (536), Expect = 5e-54
Identities = 271/1001 (27%), Positives = 441/1001 (44%), Gaps = 137/1001 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPN---AYFFAVTPKTG 77
P L ++ + E+ PV + ++A D D N LT+ ++ N A+F T TG
Sbjct: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT--TG 1906
Query: 78 EVKLASALDYETLYTFKVTISVSD----PYIQVQRE---MLVIVEDRNDNAPVFQNTAFS 130
V + LD E + +K+TISV D P I +R+ +L+ + D NDN P+F + +
Sbjct: 1907 IVTVNRPLDRERIPEYKLTISVKDNPENPRI-ARRDYDLLLIFLSDENDNHPLFTKSTYQ 1965
Query: 131 TSINETLPVGSVVF----SVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIV 186
+ E P G+ + +LA+D D +V Y + G LF I ++ +V
Sbjct: 1966 AEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL------LGAQSGLFDINSSTGVV 2019
Query: 187 LNGSLSYNNKSAF----YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242
S ++ AF +L L A D+G + ++T L I+++D D P F
Sbjct: 2020 TVRSGVIIDREAFSPPILELLLLAEDIG-LLNST--------AHLLITILDDNDNRPTFS 2070
Query: 243 REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV-NG 301
+ + E+ G SVL V A D D G+N ++Y I + + GVIRV N
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNA 2130
Query: 302 SLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPAC 361
++DRE+ E +L V AT+ A V T+ + D+ND +PEF N P
Sbjct: 2131 TIDREE----QESYRLTVVATDRGTVPLSGTAIV----TILIDDINDSRPEFLN---PIQ 2179
Query: 362 TFT------PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA 415
T + P N T +D +P++ + +V D T L DA A
Sbjct: 2180 TVSVLESAEPGTVIANITA-IDHDLNPKLEYHIVGIVAKDD------TDRLVPNQEDAFA 2232
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV--AMVTIHLRDI 473
+++ GS V+ + + YE ++V A+D ++ SV A +T+++ D+
Sbjct: 2233 VNIN----TGSVMVKSPMNRELVATYE--VTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
Query: 474 NDHRPTFPQ---SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
ND+ P F + Y+ + E + G+ + ++ A DPD G G +TY+LL Q
Sbjct: 2287 NDNTPQFKPFGITYYMERILEGATPGTTLI-AVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL--LDINDNAPVVSG 588
++ S + N +D E T++A+D G+ + + ++L +DINDN P+
Sbjct: 2346 LEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
Query: 589 -SYN--IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
SY +F G + +T+ A D D N + + ++L G F+++P TG + L
Sbjct: 2405 PSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEYSL--GDGESKFAINPTTGDIYVL 2460
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK----VNVTITVEDINDNLPIFNQSSYN 701
LDRE D +LT L D V + V V I V D+ND P F++ ++
Sbjct: 2461 SSLDREKKD-----HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
Query: 702 FTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYF---MIRGLVLGAGWAEGY 757
+V E +P G V + A D D+ N +++SL G G F M GLV + Y
Sbjct: 2516 TSVYENEPAGTSVITMMATDQDEGP-NGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSY 2574
Query: 758 LRLPPDVSLDYETQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG 815
+ F+LTV A + P G T++ V V DVNDN P V G
Sbjct: 2575 EK--------------FSLTVVATDGGEPPLWGTTML--LVEVIDVNDNRPVF-VRPPNG 2617
Query: 816 --IRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGS 873
+ + E V V A+D D ++ + L T D W +F +
Sbjct: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRY-SFLKTAGNRD-----WEFFIIDPISG 2671
Query: 874 VYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
+ I ++ +D E+ + +L++ A DL ++ L + +ED++DN P F+ K
Sbjct: 2672 L-IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQ---PLQVALEDIDDNEPLFVRPPK 2727
Query: 934 -----TFVIIPELVLPNREVASVR-ARDDDSGNNGVILFSI 968
+ +PE V +V A D D G N ++ + I
Sbjct: 2728 GSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
Score = 203 bits (516), Expect = 1e-51
Identities = 276/1029 (26%), Positives = 422/1029 (41%), Gaps = 139/1029 (13%)
Query: 42 GAQAFWLVAEDQDNDP---LTYG-MSGPNAYFFAVTPKTGEVKLAS--ALDYETLYTFKV 95
G + + +A D+D+ P + Y M G F ++P G +++ LD ET+ + +
Sbjct: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
Query: 96 TISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKD 152
TI D P + + + V D NDN PV N + +I+E PV S V VLA D D
Sbjct: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
Query: 153 MGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGM 212
G + ++I + G+ E F I A IV + Y+L + D
Sbjct: 1880 SGCNARLTFNI-----TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
Query: 213 YHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVE----AVDG 268
L +FLS D+ D P F + Y A V E++ GT + + A+D
Sbjct: 1935 PRIARRDYDLLLIFLS----DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
Query: 269 DKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327
D+ I V Y + + G FDI + GV+ V + ++ + ++L + A + L
Sbjct: 1991 DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL- 2048
Query: 328 IYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPID 387
+ + + ++D ND++P TF+P T ++ E+ P +
Sbjct: 2049 -----LNSTAHLLITILDDNDNRP----------TFSP----ATLTVHLLENCPPGFSV- 2088
Query: 388 DLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV-SALVDYERQTA 446
L + D D G NG + + + F + V ++RV +A +D E Q +
Sbjct: 2089 -LQVTATDEDSGLNGELVYRIEAGAQDRFLIH--------LVTGVIRVGNATIDREEQES 2139
Query: 447 MAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHA 505
+ VVATD + S A+VTI + DIND RP F + ++V E + G+V+ + I A
Sbjct: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN-ITA 2198
Query: 506 TDPD---------TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
D D G + L N D F V+ +G+V V++ ++RE A Y +
Sbjct: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP--MNRELVATYEV 2256
Query: 557 TLQATDGGN-------LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEE------EGNVSV 603
TL D + + L +++LD+NDN P + E G +
Sbjct: 2257 TLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Query: 604 TIQAHDNDEPGTNN--SRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661
+ A D D+ G N + L +L+P Y D G + +D E + +
Sbjct: 2317 AVAAVDPDK-GLNGLVTYTLLDLVPPGYVQ--LEDSSAGKVIANRTVDYEEVH-----WL 2368
Query: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWD 720
TV SD G P ++ V + + DINDN PIF+Q SY V E+ P G ++ V A D
Sbjct: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
Query: 721 ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780
AD I +SL G G + F I + Y+ SLD E + + LT A
Sbjct: 2429 ADSGNF-ALIEYSL-GDGESKFAINPTT-----GDIYVL----SSLDREKKDHYILTALA 2477
Query: 781 -ENPDPQGG---ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836
+NP E V V + V DVND P V EN V ++A+D
Sbjct: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF-STSVYENEPAGTSVITMMATDQ 2536
Query: 837 DTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRA 896
D E+ GV+ F V + + Q YE L
Sbjct: 2537 DEGPNGEL---TYSLEGPGVEA-------FHVDMDSGLVTTQRPLQSYEKFSLTV----- 2581
Query: 897 CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL-PENKTFVIIPELVLPNREVASVRARD 955
+ATD G LL+ + DVNDN P F+ P N T + I E + V V A D
Sbjct: 2582 --VATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 956 DDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGT 1015
D G NG + +S L+ ++D + F D +G IQ LD Q
Sbjct: 2640 KDEGLNGAVRYSFLKTAG-NRD---------WEFFI---IDPISGLIQTAQRLDRESQAV 2686
Query: 1016 YQVTVQARD 1024
Y + + A D
Sbjct: 2687 YSLILVASD 2695
Score = 197 bits (500), Expect = 7e-50
Identities = 227/777 (29%), Positives = 340/777 (43%), Gaps = 121/777 (15%)
Query: 9 FLLPALVVSVAANVAP-KFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA 67
FL P VSV + P +AN+T++ + + +VA+D D D L
Sbjct: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD-DTDRLVPNQEDA-- 2230
Query: 68 YFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQR--------EMLVIVEDRND 119
FAV TG V + S ++ E + T++VT+SV D + ++ V V D ND
Sbjct: 2231 --FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
Query: 120 NAPVFQN---TAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIP----STGD 172
N P F+ T + I E G+ + +V AVD D G G+V Y++ ++P D
Sbjct: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLED 2348
Query: 173 SEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
S + G ++ N ++ Y + ++A D G +PV+L I V
Sbjct: 2349 S-------SAGKVIANRTVDYEEVH-WLNFTVRASDNGSPPR-----AAEIPVYLEI--V 2393
Query: 233 DQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG 292
D D +P F + Y +V ED GT +LTV A D D G + YS+ F I
Sbjct: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAIN 2451
Query: 293 -ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKP 351
G I V SLDRE+ + L A + ++ + S+ V ++V+DVND +P
Sbjct: 2452 PTTGDIYVLSSLDREK----KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
Query: 352 EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP 411
+F + Q + + Y +E A + +TM+ D D+G NG SL GP
Sbjct: 2508 QF------------SKPQFSTSVYENEPAGTSV----ITMMATDQDEGPNGELTYSLEGP 2551
Query: 412 DAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQN-FSVAMVTIHL 470
EAF V + +G + Q L YE+ ++ VVATD + M+ + +
Sbjct: 2552 GVEAFHVDMD--SGLVTTQ-----RPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEV 2601
Query: 471 RDINDHRPTF--PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA-- 526
D+ND+RP F P + +L + E S V + ++ATD D G G + YS L G
Sbjct: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE-VYATDKDEGLNGAVRYSFLKTAGNRD 2660
Query: 527 -DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDN 582
+ F +DP+SG + + + LDRESQAVY L L A+D G + LQ+ L DI+DN
Sbjct: 2661 WEFFIIDPISGLI--QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDN 2718
Query: 583 APVV------SGSYNIFVQEEE-------GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPY 629
P+ S Y + E GNV+ + A + N+ + + + G
Sbjct: 2719 EPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP-----NAIVYYFIAAGNE 2773
Query: 630 SHNFSLDPDTGLLRNLGPLDRE--AIDPAL------------EGRIVLTVLVSDCGEPVL 675
NF L PD G L L LDRE AI + G LV+D
Sbjct: 2774 EKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL----- 2827
Query: 676 GTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISF 732
T V + +EDIND P F ++ Y V D V +++ D NN + F
Sbjct: 2828 -TLQEVRVVLEDINDQPPRFTKAEYTAGV-ATDAKVGSELIQVLALDADIGNNSLVF 2882
Score = 196 bits (498), Expect = 1e-49
Identities = 228/877 (25%), Positives = 387/877 (44%), Gaps = 132/877 (15%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P F +V L E+ P G + A D+D N L Y + F + TG ++
Sbjct: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
Query: 81 LASA-LDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQNTAFSTSINET 136
+ +A +D E ++++T+ +D + + ++++D ND+ P F N + S+ E+
Sbjct: 2127 VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLES 2186
Query: 137 LPVGSVVFSVLAVDKDMGS------AGMVVYS-IEKVIPSTGDSEHLFRILANGSIVLNG 189
G+V+ ++ A+D D+ G+V ++++P+ D+ F + N V+
Sbjct: 2187 AEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAVNINTGSVMVK 2243
Query: 190 SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLP-VFLSISVVDQPDLDPQFVR---EF 245
S A Y++ L D S+P L+++V+D D PQF +
Sbjct: 2244 SPMNRELVATYEVTLSVIDNASDLPER---SVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
Query: 246 YSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI--GADGVIRVNGSL 303
Y + E A GT+++ V AVD DKG+N V Y++ PG+ + + G + N ++
Sbjct: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTF 363
D E++ L T + + A++ +++ ++D+ND+ P F S F
Sbjct: 2361 DYEEVH------WLNFTVRASDNGSPPRAAEIPVYL--EIVDINDNNPIFDQPSYQEAVF 2412
Query: 364 TPEEAQVNFTGYVDEHASPRIPIDD--LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421
+P+ LT+ D D G+ SLG +++ F+++P
Sbjct: 2413 ED------------------VPVGTIILTVTATDADSGNFALIEYSLGDGESK-FAINPT 2453
Query: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV-----SQNFSVAMVTIHLRDINDH 476
+ V + +D E++ + +A D+ ++ + V I + D+ND
Sbjct: 2454 TGD--------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
RP F + + +V E+ G+ V ++ ATD D G G++TYSL G G + F VD SG
Sbjct: 2506 RPQFSKPQFSTSVYENEPAGTSVI-TMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSG 2563
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYN--- 591
VT + +S + LT+ ATDGG L +T L + ++D+NDN PV N
Sbjct: 2564 LVTTQR----PLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
Query: 592 IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHN---FSLDPDTGLLRNLGPL 648
+ ++EE S + + D+ N + ++ L + + F +DP +GL++ L
Sbjct: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
Query: 649 DREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIF-----NQSSYNF 702
DRE+ + L ++ SD G+PV T + + +EDI+DN P+F Y
Sbjct: 2680 DRES-----QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
Query: 703 -TVKEEDP-GVLVG-VVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
TV E P G LVG V A DAD E N I + YF + AG E
Sbjct: 2735 LTVPEHSPRGTLVGNVTGAVDAD--EGPNAIVY--------YF------IAAGNEEKNFH 2778
Query: 760 LPPDV------SLDYETQPVFNLTVSAEN----PDPQGGE---------TIVDVCVNVKD 800
L PD LD E + +F+ V A + P+G T+ +V V ++D
Sbjct: 2779 LQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 2838
Query: 801 VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
+ND PP A VA + ++ V+A D D
Sbjct: 2839 INDQPPRFTKAEYTA-GVATDAKVGSELIQVLALDAD 2874
Score = 185 bits (469), Expect = 3e-46
Identities = 266/1058 (25%), Positives = 439/1058 (41%), Gaps = 128/1058 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
AP F SV +PE+ PVG F + A D D + Y P + FFA+ G V
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIV 187
Query: 80 KLASALDYETLYTFKVTISVSDP----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
+ LDYET +++T++ +D + + +I+ D D P+F N +ST+I E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYN 194
P G+ V + A+D+D G + Y+I +G++ +F + +G + LNG L
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTI-----VSGNTNSIFALDYISGVLTLNGLLDRE 302
Query: 195 NK--SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
N S + L +K +L + ++ +I V+D D P+F YS ++ E
Sbjct: 303 NPLYSHGFILTVKGTELN---DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 253 DAAKGTSV-LTVEAVDGDK--GINDPV-IYSISYSTR-----PGWFDIGADGVIRVNGSL 303
A G ++ L ++ VD D+ G+N +Y + ++ P AD IRV L
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLP 359
D E + + + A E+ + G AKV I +++ ND++P F YN SL
Sbjct: 420 DYETV----DRYDFDLFANESVPDHVGY-AKVKI----TLINENDNRPIFSQPLYNISL- 469
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
+ + + LT++ D D G+ G + D + FS+
Sbjct: 470 -------------------YENVTVGTSVLTVLATDNDAGTFGE-VSYFFSDDPDRFSLD 509
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT 479
+ L+ + A +DYE + ++A D + + V I++ D+ND+ PT
Sbjct: 510 KDTG--------LIMLIARLDYELIQRFTLTIIARDGGGEE-TTGRVRINVLDVNDNVPT 560
Query: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTV 538
F + YV + E+ + + + + ATD D+ QITYS++ + F + G
Sbjct: 561 FQKDAYVGALRENEPSVTQLV-RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 539 TVRNGELLDRE--SQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+ LD E S + YLT+ A D GN L+S+ + I + D NDN P S +Y +
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679
Query: 594 VQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDRE 651
V E G + + A D D + L G S F ++ +G + LDRE
Sbjct: 680 VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG--STQFRINARSGEITTTSLLDRE 737
Query: 652 AIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE-EDPG 710
E +++ + G V IT+ DINDN P + + Y + E P
Sbjct: 738 T---KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
Query: 711 VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL-RLPPDVSLDYE 769
V V A D D E N + +S+ ++ + L R PD +E
Sbjct: 795 SDVTTVVAVDPDLGE-NGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPD---PHE 849
Query: 770 TQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHG- 826
+ + + VS + P + V VN+ D+NDN PT +L + G G
Sbjct: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEGIPAGV 907
Query: 827 QVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEA 886
+ VVA D+D L ++ + V + + F + ++ V + ++ +D E
Sbjct: 908 SIYQVVAIDLDEG------LNGLVSYRMPVGMPRMD---FLINSSSGVVVTTTE-LDRER 957
Query: 887 CDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNR 946
L V +A+D G S+ +L I + DVND P F P V + E V
Sbjct: 958 IAEYQLRV----VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYN-VSVSEDVPREF 1012
Query: 947 EVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVT 1006
V + D+D G N + + I G + G FS+ ++ V
Sbjct: 1013 RVVWLNCTDNDVGLNAELSYFI--------TGGNV--DGKFSVGYRDAV------VRTVV 1056
Query: 1007 SLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
LD Y + ++A D +G T T+ + +D
Sbjct: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
Score = 92.8 bits (229), Expect = 2e-18
Identities = 127/518 (24%), Positives = 209/518 (40%), Gaps = 77/518 (14%)
Query: 37 EDLPVGAQAFWLVAEDQD--NDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFK 94
ED+PVG + A D D N L G FA+ P TG++ + S+LD E +
Sbjct: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
Query: 95 VTISVSDPYIQVQR-------EMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL 147
+T D V ++++ V D ND P F FSTS+ E P G+ V +++
Sbjct: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532
Query: 148 AVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKA 206
A D+D G G + YS+E G F + + +G + L K + L + A
Sbjct: 2533 ATDQDEGPNGELTYSLE------GPGVEAFHVDMDSGLVTTQRPLQSYEK---FSLTVVA 2583
Query: 207 CDLG--GMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA--SVAEDAAKGTSVLT 262
D G ++ T L + V+D D P FVR + E+ ++V
Sbjct: 2584 TDGGEPPLWGTT---------MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
Query: 263 VEAVDGDKGINDPVIYSI--SYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVT 320
V A D D+G+N V YS + R F I + ++G + Q L+ + + +
Sbjct: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFI----IDPISGLIQTAQRLDRESQAVYSLI 2690
Query: 321 ATETHLNIYGQEAKVSIW--VTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378
+ L GQ + V + D++D++P F P+ + V E
Sbjct: 2691 LVASDL---GQPVPYETMQPLQVALEDIDDNEPLFVR--------PPKGSPQYQLLTVPE 2739
Query: 379 HASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSA 437
H+ + ++T V D D+G N + G + + F + P+ + V
Sbjct: 2740 HSPRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGC---------LLVLR 2789
Query: 438 LVDYERQTAMAVQVVATDSVS--------------QNFSVAMVTIHLRDINDHRPTFPQS 483
+D ER+ + V A+ + S + ++ V + L DIND P F ++
Sbjct: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
Query: 484 LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLL 521
Y V + GS + + A D D G + YS+L
Sbjct: 2850 EYTAGVATDAKVGSELI-QVLALDADIGNNSLVFYSIL 2886
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 267 bits (682), Expect = 6e-71
Identities = 238/798 (29%), Positives = 369/798 (46%), Gaps = 86/798 (10%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P F +M + + E++ G++ L A D D N +TY + F + P++G++
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLI 1797
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
LD E + + + D + + V D ND+ P F +S I E G
Sbjct: 1798 ATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPG 1857
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYNNKSAF 199
S+V ++LA D D G G + Y + + D + +F + G L L Y + +
Sbjct: 1858 SLVAAILATDDDSGVNGEITYIVNE-----DDEDGIFFLNPITGVFNLTRLLDYEVQQ-Y 1911
Query: 200 YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259
Y L ++A D GG + + + +++D D P F YS S+ E+ G++
Sbjct: 1912 YILTVRAEDGGGQFTT---------IRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGST 1962
Query: 260 VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQV 319
VL D D GIN + YSI+ G F + +GV++V +LDRE + VQ+
Sbjct: 1963 VLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVH- 2021
Query: 320 TATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEH 379
+ + + A+VSI ++DVND+ P F + P T+ PE
Sbjct: 2022 DLPQIPASRFTSTAQVSI----ILLDVNDNPPTFLS---PKLTYIPENT----------- 2063
Query: 380 ASPRIPIDDLTMVVY--DPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSA 437
PID + DPD G N +L P FS+ ++ VR++
Sbjct: 2064 -----PIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSI--------GTIDGEVRLTG 2110
Query: 438 LVDYERQTAMAVQVVATDSVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHSATG 496
+D E + + VVATD + S + V + + DIND+ P F Q+LY + + E++ TG
Sbjct: 2111 ELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTG 2170
Query: 497 SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
+ + + A D D G GQ+ Y ++ GN F++D V+G +TV + LDRE Y+L
Sbjct: 2171 TDII-QVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITV--AKPLDREKTPTYHL 2227
Query: 557 TLQATDGGNL--SSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSVTI-QAHDNDE 612
T+QATD G+ + ++T+ I LLDIND PV S Y++ V E G + TI Q D+
Sbjct: 2228 TVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD 2287
Query: 613 PGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE 672
+NS+L + L G + F+L +G L LDRE + R VL + +D G
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRET-----KERFVLMITATDSGS 2341
Query: 673 PVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRIS 731
P L + + V+D+NDN+P F +Y T+ E+ P G V +V A DAD A+
Sbjct: 2342 PALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDAD---ASKNAV 2398
Query: 732 FSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTV---SAENPDPQGG 788
+ G G + F I ++ LD ET+ + L V A +P+P
Sbjct: 2399 IRIIG-GNSQFTIN---------PSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSS 2448
Query: 789 ETIVDVCVNVKDVNDNPP 806
T V V V DVNDNPP
Sbjct: 2449 ST--SVLVTVTDVNDNPP 2464
Score = 254 bits (650), Expect = 3e-67
Identities = 287/973 (29%), Positives = 428/973 (43%), Gaps = 111/973 (11%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P F ++ +PED VG+ + A D D N + Y + F + P+TG +
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPF-QMDPETGLIT 306
Query: 81 LASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPV-----FQNTAFSTS 132
+ LD+E + +T+ D P + + E L+ + D NDN PV F T+ S
Sbjct: 307 VREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYAS 366
Query: 133 INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----LANGSIVLN 188
++E VG+VV + D D +A + V G+ + F + + N S++
Sbjct: 367 VDENAQVGTVVALLTVTDADSPAANGNI----SVQILGGNEQRHFEVQSSKVPNLSLIKV 422
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA 248
S + Y L + D G S L I V D D P F ++ Y
Sbjct: 423 ASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRV 482
Query: 249 SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGS---LDR 305
+++E+A G+ V + A DGD G+N + YSI GWF I + GS LDR
Sbjct: 483 NLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDR 542
Query: 306 EQLLEADEEVQLQVTATETHLNIYGQEAKVSI-WVTVRVMDVNDHKPEFYNCSLPACTFT 364
E ++ L ++A + G KVS + V ++DVND KP F
Sbjct: 543 ELA----SQIVLNISARDQ-----GVHPKVSYAQLVVTLLDVNDEKPVFSQ--------- 584
Query: 365 PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAA 424
PE V+ V E+A + L + D D G NGT SL + + S + +
Sbjct: 585 PEGYDVS----VVENAPTGTEL--LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVS 638
Query: 425 GSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ-NFSVAMVTIHLRDINDHRPTFPQS 483
G S +S+L D E Q ++ V+ATD S S+A + + L DIND+ P F
Sbjct: 639 GRLST-----ISSL-DREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPV 692
Query: 484 LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNG 543
Y + E+ GS +T ++ ATDPD G G + YS+ G+ + FQV+ SG ++ R
Sbjct: 693 QYFAHIKENEPGGSYIT-TVSATDPDLGTNGTVKYSISAGDRSR-FQVNAQSGVISTRMA 750
Query: 544 ELLDRESQAVYYLTLQATDGGNLSS--STTLQIHLLDINDNAPV---VSGSYNIFVQEEE 598
LDRE + Y L + ATDGGNL S + I +LD DN PV V+ S+ +F
Sbjct: 751 --LDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVAL 808
Query: 599 GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
G ++ A D NS + + + G F+++ TG L +DRE +
Sbjct: 809 GYHVGSVSASTMDL----NSNISYLITTGDQKGMFAINQVTGQLTTANVIDREE-----Q 859
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVK 717
L V+ S G V G + V ITV+D+NDN P F Q+ + V E G + K
Sbjct: 860 SFYQLKVVAS--GGTVTGDTM-VNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAK 916
Query: 718 AWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRL--PPDVSL-DYETQPVF 774
A D D+ N + +SL + N F I G + L P DV Y+ +
Sbjct: 917 AVDPDEG-VNGMVLYSLKQNPKNLFAINE-------KNGTISLLGPLDVHAGSYQIE--- 965
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
++++ PQ +++ + V V DVNDN P D S + ++E+ + + V AS
Sbjct: 966 --ILASDMGVPQLSSSVI-LTVYVHDVNDNSPVFDQLSYE-VTLSESEPVNSRFFKVQAS 1021
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVV 894
D D+ A EI T A + G F + +G +YI +D E D L+V
Sbjct: 1022 DKDSGANGEIAY-----TIAEGNTGDA----FGIFPDGQLYIKSE--LDRELQDRYVLMV 1070
Query: 895 RACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRAR 954
A D A +P S ++ + +EDVNDN P F N TF E V V A
Sbjct: 1071 VASDRAVEP----LSATVNVTVILEDVNDNRPLFNSTNYTF-YFEEEQRAGSFVGKVSAV 1125
Query: 955 DDDSGNNGVILFS 967
D D G NG + +S
Sbjct: 1126 DKDFGPNGEVRYS 1138
Score = 253 bits (645), Expect = 1e-66
Identities = 291/1107 (26%), Positives = 456/1107 (41%), Gaps = 128/1107 (11%)
Query: 37 EDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVT 96
E+ P G LV Q TY +S +A FA+ TG + S +D E+L + +
Sbjct: 53 EEQPPGT----LVGTIQTRPGFTYRLSESHA-LFAINSSTGALYTTSTIDRESLPSDVIN 107
Query: 97 ISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSA 156
+ V E+ V+V D NDNAPVF + + + E G V A D D+GS
Sbjct: 108 LVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSN 167
Query: 157 GMVVYSIEKVIPSTGDSEHLFRILANGS-------IVLNGSLSYNNKSAFYQLELKACDL 209
G V + ++I I N S +V G L + YQL ++ D
Sbjct: 168 G-VDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLD-REVTPQYQLLVEVEDK 225
Query: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
G + + ++++V D D P F Y A V EDA G+SVL V A D D
Sbjct: 226 GEPKRRGY-------LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADAD 278
Query: 270 KGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIY 329
+G N + Y + P D G+I V LD EA + L V A + +
Sbjct: 279 EGTNADIRYRLQDEGTPFQMD-PETGLITVREPLD----FEARRQYSLTVQAMDRGVPSL 333
Query: 330 GQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDL 389
A+ ++++DVND+ P PA T A VDE+A + L
Sbjct: 334 TGRAE----ALIQLLDVNDNDPVVKFRYFPA---TSRYAS------VDENAQVGTVVALL 380
Query: 390 TMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAV 449
T+ D + + LGG + F V + + L++V++ +D ER + +
Sbjct: 381 TVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLS----LIKVASALDRERIPSYNL 436
Query: 450 QVVATD--------SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTD 501
V +D +V SVA + I + DINDH P F Q +Y + + E + GS V+
Sbjct: 437 TVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVS- 495
Query: 502 SIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQAT 561
I ATD D+G + YS++ GNG F + SG VT + LDRE + L + A
Sbjct: 496 GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISAR 555
Query: 562 DGG--NLSSSTTLQIHLLDINDNAPVVS--GSYNIFVQEEEGNVSVTIQAHDNDEPGTNN 617
D G S L + LLD+ND PV S Y++ V E + + D +N
Sbjct: 556 DQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDN 615
Query: 618 SRLLFNLLPGPYS-HNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
+ F+L +F LDP +G L + LDRE + L VL +D G P
Sbjct: 616 GTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREE-----QAFYSLLVLATDLGSPPQS 670
Query: 677 TKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLS 735
+ + +++ DINDN P+F Y +KE +P G + V A D D N + +S+S
Sbjct: 671 SMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPD-LGTNGTVKYSIS 729
Query: 736 GSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVC 795
+ F + G + ++LD E + + L + A + V
Sbjct: 730 AGDRSRFQVNA-------QSGV--ISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVT 780
Query: 796 VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAG 855
+ V D DNPP + + V EN + V V AS +D ++ ++ L T
Sbjct: 781 ITVLDTQDNPPVFSQVAYSFV-VFENVALGYHVGSVSASTMDLNSN-----ISYLITTGD 834
Query: 856 VDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLL 915
G F++ + + + ID E L V A + + +
Sbjct: 835 QK------GMFAI-NQVTGQLTTANVIDREEQSFYQLKVVASG-------GTVTGDTMVN 880
Query: 916 ITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFIS 975
IT++D+NDN+P+FL ++ V + E + +A D D G NG++L+S+
Sbjct: 881 ITVKDLNDNSPHFLQAIES-VNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK------ 933
Query: 976 KDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEAT 1035
Q ++F +E + G+I + LD G+YQ+ + A D P L ++
Sbjct: 934 --------QNPKNLFAINEKN---GTISLLGPLD-VHAGSYQIEILASDMGV--PQLSSS 979
Query: 1036 TTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAARARP 1095
L ++ D + S + E + + +N+ + V D DS A
Sbjct: 980 VILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF--------FKVQASDKDSGANGEI 1031
Query: 1096 HSYL------DAYFVFPNGSALTLDEL 1116
+ DA+ +FP+G EL
Sbjct: 1032 AYTIAEGNTGDAFGIFPDGQLYIKSEL 1058
Score = 244 bits (623), Expect = 4e-64
Identities = 287/1047 (27%), Positives = 455/1047 (43%), Gaps = 132/1047 (12%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNA-YF 69
+ VS + PKF + S +PED G+ ++A D D N +TY ++ +
Sbjct: 1829 ITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGI 1888
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQR-EMLVIVEDRNDNAPVFQNTA 128
F + P TG L LDYE + +T+ D Q + + D NDN P+F +
Sbjct: 1889 FFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNS 1948
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLN 188
+STS+ E LPVGS V D D G + YSI ++GDS F + NG + +
Sbjct: 1949 YSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI-----ASGDSLGQFTVDKNGVLKVL 2003
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA 248
+L ++S FY L ++ DL + + FT +SI ++D D P F+ +
Sbjct: 2004 KALDRESQS-FYNLVVQVHDLPQIPASRFTSTAQ----VSIILLDVNDNPPTFLSPKLT- 2057
Query: 249 SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQ 307
+ E+ T V +A D D G N + Y++ + F IG DG +R+ G LDRE+
Sbjct: 2058 YIPENTPIDTVVFKAQATDPDSGPNSYIEYTL-LNPLGNKFSIGTIDGEVRLTGELDREE 2116
Query: 308 LLEADEEVQLQVTATETHLNIYGQEA-KVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
+ L V AT+ GQ + S V V V+D+ND+ P F
Sbjct: 2117 V----SNYTLTVVATDK-----GQPSLSSSTEVVVMVLDINDNNPIF------------- 2154
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAG 425
AQ + ++E+ D + + D D+G+NG + G + F +
Sbjct: 2155 -AQALYKVEINENT--LTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRID------ 2205
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVS-QNFSVAMVTIHLRDINDHRPTFPQSL 484
SV + V+ +D E+ + V ATD S + V+I L DIND P F S
Sbjct: 2206 --SVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSP 2263
Query: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544
Y + VPE+ T + A D D G+ +++Y L GN + F + SG + V +
Sbjct: 2264 YSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVT--Q 2320
Query: 545 LLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPV-VSGSYNIFVQEEEGNV 601
LDRE++ + L + ATD G+ L+ + T+ + + D+NDN P S +Y + E+
Sbjct: 2321 SLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTG 2380
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661
+ + + +D + N+ + ++ G + F+++P TG + LDRE D
Sbjct: 2381 TDVLLVNASDADASKNA--VIRIIGG--NSQFTINPSTGQIITSALLDRETKD-----NY 2431
Query: 662 VLTVLVSDCGEP-VLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED-PGVLVGVVKAW 719
L V+ SD G P L + +V +TV D+NDN P F Y + PG V V
Sbjct: 2432 TLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2491
Query: 720 DADQTEANNRISFSLSGSGANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
DAD N+ + +SLSG + F I RG ++ AG L+ ++ F++
Sbjct: 2492 DAD-IGPNSELHYSLSGRNSEKFHIDPLRGAIMAAG------------PLNGASEVTFSV 2538
Query: 777 TVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836
V P+ T V V+ VN D +R ++ V+ +V +
Sbjct: 2539 HVKDGGSFPKTDST----TVTVRFVN----KADFPKVRAKEQTFMFPENQPVSSLVTTIT 2590
Query: 837 DTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLVTLVVR 895
+S + E I G F + G V I+Q +D+E + +
Sbjct: 2591 GSSLRGEPMSYYIASGNLG--------NTFQIDQLTGQVSISQ--PLDFEKIQKYVVWIE 2640
Query: 896 ACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELV--LPNREVASVRA 953
A D GF +S+ L IT+ DVNDNAP F K I E++ L R++ +V A
Sbjct: 2641 ----ARDGGFPPFSSYEKLDITVLDVNDNAPIF----KEDPFISEILENLSPRKILTVSA 2692
Query: 954 RDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQ 1013
D DSG NG + + I+ + + FSI ++ G I+ V LD
Sbjct: 2693 MDKDSGPNGQLDYEIVNGN----------MENSFSINHAT------GEIRSVRPLDREKV 2736
Query: 1014 GTYQVTVQARDRPSLGPFLEATTTLNL 1040
Y +T+++ D+ S +N+
Sbjct: 2737 SHYVLTIKSSDKGSPSQSTSVKVMINI 2763
Score = 238 bits (606), Expect = 4e-62
Identities = 274/928 (29%), Positives = 413/928 (44%), Gaps = 132/928 (14%)
Query: 70 FAVTPKTGEVKLASALDYET---LYTFKV-TISVSDPYIQVQR-EMLVIVEDRNDNAPVF 124
F + TG ++ A+ LD E LY V I S + + QR E+ + ++D NDN PVF
Sbjct: 1681 FTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVF 1740
Query: 125 QNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANG 183
++ E + GS + + A+D D G+ +V Y+I I DS FRI +G
Sbjct: 1741 PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTI---ISGADDS---FRIDPESG 1794
Query: 184 SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243
++ L +S Y L ++A D G+ + I +I+V D D P+F R
Sbjct: 1795 DLIATRRLDRERRSK-YSLLVRADD--GLQSSDMRI--------NITVSDVNDHTPKFSR 1843
Query: 244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSL 303
YS + ED G+ V + A D D G+N + Y ++ G F + + G
Sbjct: 1844 PVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNP-----ITGVF 1898
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLP 359
+ +LL D EVQ T + GQ + ++ ++DVND+ P F Y+ SL
Sbjct: 1899 NLTRLL--DYEVQQYYILTVRAEDGGGQFTTIRVY--FNILDVNDNPPIFSLNSYSTSL- 1953
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMV--VYDPDKGSNGTFLLSLGGPDA-EAF 416
+P+ +V V D D G N S+ D+ F
Sbjct: 1954 ---------------------MENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQF 1992
Query: 417 SVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD----SVSQNFSVAMVTIHLRD 472
+V +++V +D E Q+ + V D S+ S A V+I L D
Sbjct: 1993 TVDKNG---------VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLD 2043
Query: 473 INDHRPTF--PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
+ND+ PTF P+ Y +PE++ +VV + ATDPD+G I Y+LL G + F
Sbjct: 2044 VNDNPPTFLSPKLTY---IPENTPIDTVVFKA-QATDPDSGPNSYIEYTLLNPLG-NKFS 2098
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
+ + G V + GE LDRE + Y LT+ ATD G +LSSST + + +LDINDN P+ +
Sbjct: 2099 IGTIDGEVRL-TGE-LDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQ 2156
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
+ Y + + E G + + A D DE GT N ++ + ++ G + F +D TG +
Sbjct: 2157 ALYKVEINENTLTGTDIIQVFAADGDE-GT-NGQVRYGIVNGNTNQEFRIDSVTGAITVA 2214
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
PLDRE P LTV +D G V+I + DIND +P+F S Y+ V
Sbjct: 2215 KPLDREK-TPTYH----LTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVP 2269
Query: 706 EE---DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPP 762
E P ++ VV D +N+++S+ L G + L A G +
Sbjct: 2270 ENLGTLPRTILQVVAR--DDDRGSNSKLSYVLFGGNED----NAFTLSASGELGVTQ--- 2320
Query: 763 DVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENG 822
SLD ET+ F L ++A + + V V DVNDN PT + + E+
Sbjct: 2321 --SLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTF-ASKAYFTTIPEDA 2377
Query: 823 SQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSV-YINQSKA 881
V +V ASD D S I+++ G N S I S
Sbjct: 2378 PTGTDVLLVNASDADASKNAVIRIIG---------------GNSQFTINPSTGQIITSAL 2422
Query: 882 IDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVI-IPE 940
+D E D TLVV C A P + S++ S+L+T+ DVNDN P F ++ +V IP
Sbjct: 2423 LDRETKDNYTLVV-VCSDAGSP--EPLSSSTSVLVTVTDVNDNPPRF--QHHPYVTHIPS 2477
Query: 941 LVLPNREVASVRARDDDSGNNGVILFSI 968
LP V +V D D G N + +S+
Sbjct: 2478 PTLPGSFVFAVTVTDADIGPNSELHYSL 2505
Score = 229 bits (584), Expect = 1e-59
Identities = 270/1036 (26%), Positives = 426/1036 (41%), Gaps = 130/1036 (12%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMSGPNAYFFAVTPKTGEVK 80
P FL+ + I PE+ P+ F A D D+ P + Y + P F++ GEV+
Sbjct: 2049 PTFLSPKLTYI-PENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107
Query: 81 LASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETL 137
L LD E + + +T+ +D P + E++V+V D NDN P+F + INE
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENT 2167
Query: 138 PVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNK 196
G+ + V A D D G+ G V Y I G++ FRI G+I + L K
Sbjct: 2168 LTGTDIIQVFAADGDEGTNGQVRYGI-----VNGNTNQEFRIDSVTGAITVAKPLD-REK 2221
Query: 197 SAFYQLELKACDLGGMYH-NTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAED-A 254
+ Y L ++A D G +T T+ SI ++D D P F YS +V E+
Sbjct: 2222 TPTYHLTVQATDRGSTPRTDTSTV--------SIVLLDINDFVPVFELSPYSVNVPENLG 2273
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEE 314
++L V A D D+G N + Y + F + A G + V SLDR E E
Sbjct: 2274 TLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDR----ETKER 2329
Query: 315 VQLQVTATETHLNIYGQEAKVSI-WVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
L +TAT++ G A + V V DVND+ P F S T PE+A
Sbjct: 2330 FVLMITATDS-----GSPALTGTGTINVIVDDVNDNVPTF--ASKAYFTTIPEDAPTG-- 2380
Query: 374 GYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLV 433
D L + D D N + +GG F+++P +
Sbjct: 2381 ------------TDVLLVNASDADASKNAVIRI-IGG--NSQFTINPSTGQ--------I 2417
Query: 434 RVSALVDYERQTAMAVQVVATDSVSQN--FSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
SAL+D E + + VV +D+ S S V + + D+ND+ P F YV +P
Sbjct: 2418 ITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPS 2477
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
+ GS V ++ TD D G ++ YS L G ++ F +DP+ G + L+ S+
Sbjct: 2478 PTLPGSFVF-AVTVTDADIGPNSELHYS-LSGRNSEKFHIDPLRGAIMAAGP--LNGASE 2533
Query: 552 AVYYLTLQATDGGNL--SSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHD 609
+ ++ DGG+ + STT+ + ++ D P V F+ E VS +
Sbjct: 2534 VTF--SVHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQPVSSLVTTIT 2590
Query: 610 NDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSD 669
+ + + G + F +D TG + PLD E I + V+ + D
Sbjct: 2591 GS--SLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQ-----KYVVWIEARD 2643
Query: 670 CGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNR 729
G P + + ITV D+NDN PIF + + + E + V A D D + N +
Sbjct: 2644 GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKD-SGPNGQ 2702
Query: 730 ISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGG 788
+ + + +G+ N F I A G +R LD E + LT+ + +
Sbjct: 2703 LDYEIVNGNMENSFSI-------NHATGEIRSVR--PLDREKVSHYVLTIKSSDKGSPSQ 2753
Query: 789 ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVN 848
T V V +N+ D NDN P + + V EN V V SD D +N
Sbjct: 2754 STSVKVMINILDENDNAPRF--SQIFSAHVPENSPLGYTVTRVTTSDEDIG-------IN 2804
Query: 849 ILCTKAGVDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQA 907
+ + +D F++ + G + I S+ ++ E D + V A D
Sbjct: 2805 AISRYSIMDASLP----FTINPSTGDIVI--SRPLNREDTDRYRIRVSAHD-------SG 2851
Query: 908 YSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFS 967
++ + + I + D+NDNAP F ++ PEL +V V A D D G+NG + +
Sbjct: 2852 WTVSTDVTIFVTDINDNAPRF-SRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY- 2909
Query: 968 ILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI---QPVTSLDSTLQGTYQVTVQARD 1024
I Q + ++ ++F I Q VT + + V + D
Sbjct: 2910 ------------FIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSD 2957
Query: 1025 RPSLGPFLEATTTLNL 1040
R E T T+N+
Sbjct: 2958 RGKPSLISETTVTINI 2973
Score = 225 bits (574), Expect = 2e-58
Identities = 277/1062 (26%), Positives = 442/1062 (41%), Gaps = 133/1062 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF-------FAVTPK 75
AP+F + + S +PE+ P+G + D+D G++ + Y F + P
Sbjct: 2770 APRF-SQIFSAHVPENSPLGYTVTRVTTSDED-----IGINAISRYSIMDASLPFTINPS 2823
Query: 76 TGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
TG++ ++ L+ E +++ +S D V ++ + V D NDNAP F T++ E
Sbjct: 2824 TGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPE 2883
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYN 194
+GS V V A D D GS G V Y I+ SE+ FRI A G I L Y
Sbjct: 2884 LTEIGSKVTQVFATDPDEGSNGQVFYFIK------SQSEY-FRINATTGEIFNKQILKYQ 2936
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
N + F + + + ++I++VD D PQF++ Y V ++
Sbjct: 2937 NVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNV 2996
Query: 255 AKGTSVLTVEAVDG-DKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEAD 312
GT ++ V A+D D G+N V Y IS G F + D G I V SL + + +
Sbjct: 2997 KVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSL----ISDLN 3052
Query: 313 EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNF 372
+ + VTA + +A V I VT + N H PEF + A PE +
Sbjct: 3053 QNFFITVTAKDKGNPPLSSQATVHITVT----EENYHTPEFSQSHMSAT--IPESHSI-- 3104
Query: 373 TGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVL 432
G + S R D D NG S+ + E A ++S +L
Sbjct: 3105 -GSIVRTVSAR-----------DRDAAMNGLIKYSISSGNEEGI------FAINSSTGIL 3146
Query: 433 VRVSALVDYE--RQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVP 490
AL DYE ++ M + + V++ VT+++ D+ND+ P F Y TV
Sbjct: 3147 TLAKAL-DYELCQKHEMTISAIDGGWVART-GYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204
Query: 491 EHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRES 550
E++ +G+ V ++ATD D+G I Y+ + + +DLF +DP +G +T + LD E+
Sbjct: 3205 ENAPSGTTVI-HLNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQG--FLDFET 3260
Query: 551 QAVYYLTLQA--TDGGNLSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEEGNVSVTIQA 607
+ Y+LT++A S T+ I L N+ P VS Y + E ++ +
Sbjct: 3261 KQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEV 3320
Query: 608 HDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLV 667
+D + + + + F ++ TG + G LDRE E R+ L VL
Sbjct: 3321 FASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK-----EERVSLKVLA 3375
Query: 668 SDCGEPVLGT---KVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQ 723
+ G + G +V V +TV D ND PIF + Y+ + E P G V V A+D+D
Sbjct: 3376 KNFGS-IRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDS 3433
Query: 724 TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENP 783
+ +R S+ + N G ++ LD ET P++NL+V A +
Sbjct: 3434 IPSWSRFSYFIGSGNENGAFSINPQTG--------QITVTAELDRETLPIYNLSVLAVDS 3485
Query: 784 DPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLE 843
+ V ++D+NDN P L V+ V EN V + ++D D
Sbjct: 3486 GTPSATGSASLLVTLEDINDNGPMLTVSE---GEVMENKRPGTLVMTLQSTDPDLPPNQG 3542
Query: 844 IQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDP 903
+L T +FS++ G ++ ++ ID E L V + D
Sbjct: 3543 PFTYYLLSTGPAT-------SYFSLSTAG--VLSTTREIDREQIADFYLSV----VTKDS 3589
Query: 904 GFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGV 963
G S+ G++ IT+ D NDN P + FV + P + SV+ +D D
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDN-PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD------ 3642
Query: 964 ILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQAR 1023
+ S GV S+F+ G + S + GT+ +TV +
Sbjct: 3643 -VLDSFHCSLTS---------GVTSLFS------IPGGTCDLNSQPRSTDGTFDLTVLSN 3686
Query: 1024 DRPSLGPFLEATTTLNLF-------TVDQSYRSRLQFSTPKE 1058
D G T+ + +F TVD S RL T K+
Sbjct: 3687 D----GVHSTVTSNIRVFFAGFSNATVDNSILLRLGVPTVKD 3724
Score = 223 bits (568), Expect = 9e-58
Identities = 235/845 (27%), Positives = 380/845 (44%), Gaps = 86/845 (10%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMS-GPNAYFFAVTPKTGEVKL 81
P F S ++ E++ +G + A D N ++Y ++ G FA+ TG++
Sbjct: 791 PVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTT 850
Query: 82 ASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGS 141
A+ +D E +++ + S + + + V+D NDN+P F S ++ E G
Sbjct: 851 ANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGH 910
Query: 142 VVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFY 200
+F AVD D G GMV+YS+++ + ++LF I NG+I L G L + S Y
Sbjct: 911 SIFQAKAVDPDEGVNGMVLYSLKQ------NPKNLFAINEKNGTISLLGPLDVHAGS--Y 962
Query: 201 QLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSV 260
Q+E+ A D+G Q S V L++ V D D P F + Y +++E +
Sbjct: 963 QIEILASDMG-------VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF 1015
Query: 261 LTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVT 320
V+A D D G N + Y+I+ F I DG + + LDR E + L V
Sbjct: 1016 FKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDR----ELQDRYVLMVV 1071
Query: 321 ATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHA 380
A++ + + ++ VTV + DVND++P F + N+T Y +E
Sbjct: 1072 ASDRAV----EPLSATVNVTVILEDVNDNRPLFNS--------------TNYTFYFEEEQ 1113
Query: 381 SPRIPIDDLTMVVYDPDKGSNG--TFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSAL 438
+ ++ V D D G NG + + PD E ++S E + R S +
Sbjct: 1114 RAGSFVGKVSAV--DKDFGPNGEVRYSFEMVQPDFELHAISGE----ITNTHQFDRESLM 1167
Query: 439 VDYERQTAM-AVQVVATD-SVSQNF-SVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSAT 495
R TA+ + V+ATD + Q A V ++++DIND+ P F + Y T+ E +A
Sbjct: 1168 --RRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAAN 1225
Query: 496 GSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYY 555
+ V + A+D D G G I YS++ GN F +D SG VT+ LD E+ Y
Sbjct: 1226 LTQVL-RVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIG--KLDYEATPAYS 1282
Query: 556 LTLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEE----GNVSVTIQAHD 609
L +QA D G L+S+ TL I +LD NDN P S +FV E G + ++ A D
Sbjct: 1283 LVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS-TLFVDVLENMRIGELVSSVTATD 1341
Query: 610 NDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSD 669
+D +N+ L +++ FS+ P+TG + LD E + L + D
Sbjct: 1342 SD--SGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFET-----QSLYKLNITAKD 1394
Query: 670 CGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANN 728
G P + ++V I V D NDN P F ++ E P G V V A D D + N
Sbjct: 1395 QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPD-ADING 1453
Query: 729 RISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAEN---PDP 785
++S+++ M RG +G + + +D E +F LTV A + P
Sbjct: 1454 QLSYTIIQQ-----MPRGNHFTIDEVKG--TIYTNAEIDREFANLFELTVKANDQAVPIE 1506
Query: 786 QGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA--QLE 843
+ +V + V D+NDN P S + + + ++A+D D A ++E
Sbjct: 1507 TRRYALKNVTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIE 1564
Query: 844 IQLVN 848
+++N
Sbjct: 1565 YEIIN 1569
Score = 222 bits (566), Expect = 2e-57
Identities = 291/1050 (27%), Positives = 457/1050 (43%), Gaps = 138/1050 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY-FFAVTPKTGEV 79
P F + V + E++ +G + A D D N L Y ++G N + F+++P TG +
Sbjct: 1313 PSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSI 1372
Query: 80 KLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINET 136
LA LD+ET +K+ I+ D P +++ V D NDN P F SI E
Sbjct: 1373 FLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVEN 1432
Query: 137 LPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNK 196
+P+G+ V SV A D D G + Y+I + +P H G+I N +
Sbjct: 1433 IPIGTSVISVTAHDPDADINGQLSYTIIQQMPR---GNHFTIDEVKGTIYTNAEIDREFA 1489
Query: 197 SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAK 256
+ F +L +KA D T + +L ++I V D D P F+ + +A A+ +A
Sbjct: 1490 NLF-ELTVKANDQAVPIE---TRRYALKN-VTILVTDLNDNVPMFISQ--NALAADPSAV 1542
Query: 257 GTSVLT-VEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEV 315
SVLT + A D D+G N + Y I + G +RV +L QL+
Sbjct: 1543 IGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPSQLI-----Y 1597
Query: 316 QLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGY 375
L V+AT+ G E + S ++ D P F + P +E + T
Sbjct: 1598 NLIVSATDL-----GPERRKSTTELTIILQGLDG-PVF---TQPKYITILKEGEPIGTNV 1648
Query: 376 VD-EHASPR---IPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQV 431
+ E ASPR P++ + V +K F + R G
Sbjct: 1649 ISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIG--------------RHTG------ 1688
Query: 432 LVRVSALVDYERQTAMAVQVVATDSVSQNF---SVAMVTIHLRDINDHRPTFPQSLYVLT 488
+++ +A++D E+ + + V S F A V I L+DIND+ P FP + LT
Sbjct: 1689 IIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLT 1748
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDR 548
V E+ GS + + A D D GA +TY+++ G D F++DP SG + LDR
Sbjct: 1749 VEENIGDGSKIMQ-LTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRR--LDR 1804
Query: 549 ESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEE--GNVSVTI 605
E ++ Y L ++A DG SS + I + D+ND+ P S Y+ + E+ G++ I
Sbjct: 1805 ERRSKYSLLVRADDGLQ-SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAI 1863
Query: 606 QAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTV 665
A D+D N + + + F L+P TG+ LD E ++ +LTV
Sbjct: 1864 LATDDDSGV--NGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYE-----VQQYYILTV 1916
Query: 666 LVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQT 724
D G T + V + D+NDN PIF+ +SY+ ++ E P G V V DAD
Sbjct: 1917 RAEDGGGQF--TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDG 1974
Query: 725 EANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAEN- 782
N+++++S+ SG F + G L++ +LD E+Q +NL V +
Sbjct: 1975 -INSQLTYSIASGDSLGQFTVD--------KNGVLKVLK--ALDRESQSFYNLVVQVHDL 2023
Query: 783 ---PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDT- 838
P + T V + + DVNDNPPT S + + EN V A+D D+
Sbjct: 2024 PQIPASRFTST-AQVSIILLDVNDNPPTF--LSPKLTYIPENTPIDTVVFKAQATDPDSG 2080
Query: 839 -SAQLEIQLVNILCTKAGVDVGSLCWGWFSVAA-NGSVYINQSKAIDYEACDLVTLVVRA 896
++ +E L+N L K FS+ +G V + +D E TL V
Sbjct: 2081 PNSYIEYTLLNPLGNK------------FSIGTIDGEVRLTGE--LDREEVSNYTLTV-- 2124
Query: 897 CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDD 956
+ATD G + S++ +++ + D+NDN P F + V I E L ++ V A D
Sbjct: 2125 --VATDKGQPSLSSSTEVVVMVLDINDNNPIFA-QALYKVEINENTLTGTDIIQVFAADG 2181
Query: 957 DSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSE--ADVFAGSIQPVTSLDSTLQG 1014
D G NG + + I+ + T+ E D G+I LD
Sbjct: 2182 DEGTNGQVRYGIVNGN------------------TNQEFRIDSVTGAITVAKPLDREKTP 2223
Query: 1015 TYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
TY +TVQA DR S +T ++ L ++
Sbjct: 2224 TYHLTVQATDRGSTPRTDTSTVSIVLLDIN 2253
Score = 218 bits (556), Expect = 2e-56
Identities = 283/1070 (26%), Positives = 451/1070 (42%), Gaps = 137/1070 (12%)
Query: 7 SCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMS 63
S +L V V N +P F V L E PV ++ F + A D+D N + Y ++
Sbjct: 978 SSVILTVYVHDVNDN-SPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIA 1036
Query: 64 -GPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQ---VQREMLVIVEDRND 119
G F + P G++ + S LD E + + + SD ++ + VI+ED ND
Sbjct: 1037 EGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVND 1095
Query: 120 NAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI 179
N P+F +T ++ E GS V V AVDKD G G V YS E V P + +
Sbjct: 1096 NRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDF-ELHAISGE 1154
Query: 180 LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDP 239
+ N SL +A + + A D G Q ++ V++ D D P
Sbjct: 1155 ITNTHQFDRESLMRRRGTAVFSFTVIATDQG--IPQPLKDQATVHVYMK----DINDNAP 1208
Query: 240 QFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIR 298
+F+++FY A+++E AA T VL V A D D+G N + YSI F I G +
Sbjct: 1209 KFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVT 1268
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+ G LD EA L + A ++ ++I ++D ND+ P F +L
Sbjct: 1269 LIGKLD----YEATPAYSLVIQAVDSGTIPLNSTCTLNI----DILDENDNTPSFPKSTL 1320
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAE-AFS 417
+VD + RI ++ D D G N S+ G + FS
Sbjct: 1321 ----------------FVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFS 1364
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAM-VTIHLRDINDH 476
+SP + + ++ +D+E Q+ + + A D S M V IH+RD ND+
Sbjct: 1365 ISPNTGS--------IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDN 1416
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLP----GNGADLFQVD 532
P+FP ++ E+ G+ V S+ A DPD GQ++Y+++ GN F +D
Sbjct: 1417 PPSFPPGDIFKSIVENIPIGTSVI-SVTAHDPDADINGQLSYTIIQQMPRGNH---FTID 1472
Query: 533 PVSGTVTVRNGELLDRESQAVYYLTLQATDGG-----NLSSSTTLQIHLLDINDNAPVVS 587
V GT+ N E +DRE ++ LT++A D + + I + D+NDN P+
Sbjct: 1473 EVKGTI-YTNAE-IDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI 1530
Query: 588 GSYNIFVQEEE---GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRN 644
S N + G+V TI A D DE N + + ++ G + F +D +G LR
Sbjct: 1531 -SQNALAADPSAVIGSVLTTIMAADPDEGA--NGEIEYEIINGD-TDTFIVDRYSGDLRV 1586
Query: 645 LGPLDREAIDPALEGRIVLTVLVS--DCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNF 702
L + +++ ++VS D G + +TI ++ ++ P+F Q Y
Sbjct: 1587 ASAL--------VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYIT 1636
Query: 703 TVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR--- 759
+KE +P + V+ A + + + + + G + G G ++
Sbjct: 1637 ILKEGEP-IGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTV-GRLFTIGRHTGIIQTAA 1694
Query: 760 -LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRV 818
L + V+ + S P Q E V + ++D+NDNPP L + V
Sbjct: 1695 ILDREQGACLYLVDVYAIEKSTAFPRTQRAE----VEITLQDINDNPPVFPTDML-DLTV 1749
Query: 819 AENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQ 878
EN ++ + A D D A + I +G D F + I
Sbjct: 1750 EENIGDGSKIMQLTAMDADEGANALVTYTII----SGADDS------FRIDPESGDLI-A 1798
Query: 879 SKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVII 938
++ +D E +L+VRA D G Q S++ + IT+ DVND+ P F +F I
Sbjct: 1799 TRRLDRERRSKYSLLVRA-----DDGLQ--SSDMRINITVSDVNDHTPKFSRPVYSF-DI 1850
Query: 939 PELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATI--PFQGVFSIFTSSEAD 996
PE +P VA++ A DDDSG NG I + + D +DG P GVF++
Sbjct: 1851 PEDTIPGSLVAAILATDDDSGVNGEITYIVNEDD---EDGIFFLNPITGVFNL------- 1900
Query: 997 VFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQS 1046
LD +Q Y +TV+A D G F N+ V+ +
Sbjct: 1901 --------TRLLDYEVQQYYILTVRAED--GGGQFTTIRVYFNILDVNDN 1940
Score = 200 bits (509), Expect = 6e-51
Identities = 253/970 (26%), Positives = 394/970 (40%), Gaps = 123/970 (12%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P F N S L E+LPVG+ D D N LTY ++ ++ K G +K
Sbjct: 1942 PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLK 2001
Query: 81 LASALDYETLYTFKVTISVSD-PYIQVQR-----EMLVIVEDRNDNAPVFQNTAFSTSIN 134
+ ALD E+ + + + V D P I R ++ +I+ D NDN P F + T I
Sbjct: 2002 VLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIP 2060
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYN 194
E P+ +VVF A D D G + Y++ + G+ + I +G + L G L
Sbjct: 2061 ENTPIDTVVFKAQATDPDSGPNSYIEYTL---LNPLGNKFSIGTI--DGEVRLTGELDRE 2115
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
S Y L + A D G ++ T + + V+D D +P F + Y + E+
Sbjct: 2116 EVSN-YTLTVVATDKGQPSLSSSTE-------VVVMVLDINDNNPIFAQALYKVEINENT 2167
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADE 313
GT ++ V A DGD+G N V Y I F I + G I V LDRE+
Sbjct: 2168 LTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKT----P 2223
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLPACTFTPEEAQ 369
L V AT+ + VSI + +D+ND P F Y+ ++P T
Sbjct: 2224 TYHLTVQATDRGSTPRTDTSTVSIVL----LDINDFVPVFELSPYSVNVPENLGT----- 2274
Query: 370 VNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSAS 428
+P L +V D D+GSN L GG + AF++S G
Sbjct: 2275 --------------LPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELG--- 2317
Query: 429 VQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFPQSLYVL 487
V+ +D E + + + ATDS S + + + + D+ND+ PTF Y
Sbjct: 2318 ------VTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFT 2371
Query: 488 TVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLD 547
T+PE + TG TD + D A ++ GN F ++P +G + LLD
Sbjct: 2372 TIPEDAPTG---TDVLLVNASDADASKNAVIRIIGGNSQ--FTINPSTGQIIT--SALLD 2424
Query: 548 RESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSV 603
RE++ Y L + +D G+ LSSST++ + + D+NDN P Y + S
Sbjct: 2425 RETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSF 2484
Query: 604 TIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVL 663
D NS L ++L G S F +DP G + GPL+ + +
Sbjct: 2485 VFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLNGAS-------EVTF 2536
Query: 664 TVLVSDCGEPVLGTKVNVTITVEDIND-NLPIFNQSSYNFTVKEEDPGVLVGVVKAWDAD 722
+V V D G + T+TV +N + P F E P + +V
Sbjct: 2537 SVHVKDGGS--FPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQP--VSSLVTTITGS 2592
Query: 723 QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAEN 782
+ SG+ N F I L ++ LD+E + + + A +
Sbjct: 2593 SLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQ---------PLDFEKIQKYVVWIEARD 2643
Query: 783 PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDT--SA 840
+ + + V DVNDN P + EN S ++ V A D D+ +
Sbjct: 2644 GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFIS-EILENLSPR-KILTVSAMDKDSGPNG 2701
Query: 841 QLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLA 900
QL+ ++VN G++ + A G I + +D E L +++
Sbjct: 2702 QLDYEIVN----------GNMENSFSINHATGE--IRSVRPLDREKVSHYVLTIKS---- 2745
Query: 901 TDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTF-VIIPELVLPNREVASVRARDDDSG 959
+D G + S + ++I I D NDNAP F ++ F +PE V V D+D G
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRF---SQIFSAHVPENSPLGYTVTRVTTSDEDIG 2802
Query: 960 NNGVILFSIL 969
N + +SI+
Sbjct: 2803 INAISRYSIM 2812
Score = 194 bits (493), Expect = 5e-49
Identities = 285/1180 (24%), Positives = 484/1180 (41%), Gaps = 179/1180 (15%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP-----LTYGMSGPNAYFFAVTPKTGE 78
P F + + E+ G+ + A D+D P ++ M P+ A++ GE
Sbjct: 1098 PLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAIS---GE 1154
Query: 79 VKLASALDYETLY------TFKVTISVSDPYI----QVQREMLVIVEDRNDNAPVFQNTA 128
+ D E+L F T+ +D I + Q + V ++D NDNAP F
Sbjct: 1155 ITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDF 1214
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVL 187
+ +I+E+ + V V A D D G+ G++ YSI K G+ E F I +G + L
Sbjct: 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIK-----GNEERQFAIDSTSGQVTL 1269
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
G L Y A Y L ++A D G TI + L+I ++D+ D P F +
Sbjct: 1270 IGKLDYEATPA-YSLVIQAVDSG-------TIPLNSTCTLNIDILDENDNTPSFPKSTLF 1321
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDRE 306
V E+ G V +V A D D G N + YSI+ + G F I + G I + LD
Sbjct: 1322 VDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLD-- 1379
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIW-VTVRVMDVNDHKPEFYNCSLPACTFTP 365
E +L +TA + G+ + S V + V D ND+ P F
Sbjct: 1380 --FETQSLYKLNITAKDQ-----GRPPRSSTMSVVIHVRDFNDNPPSFP----------- 1421
Query: 366 EEAQVNFTGYVDEHASPRIPIDD--LTMVVYDPDKGSNG--TFLLSLGGPDAEAFSVSPE 421
G + + IPI +++ +DPD NG ++ + P F++
Sbjct: 1422 -------PGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTID-- 1472
Query: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV----SQNFSVAMVTIHLRDINDHR 477
V+ + +A +D E + V A D ++ +++ VTI + D+ND+
Sbjct: 1473 ------EVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNV 1526
Query: 478 PTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGT 537
P F S L + GSV+T +I A DPD GA G+I Y ++ G+ D F VD SG
Sbjct: 1527 PMFI-SQNALAADPSAVIGSVLT-TIMAADPDEGANGEIEYEIINGD-TDTFIVDRYSGD 1583
Query: 538 VTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEE 597
+ V + + SQ +Y L + ATD G +T ++ ++ + PV + I + +E
Sbjct: 1584 LRVASALV---PSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKE 1640
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLL-----PGPYSHNFSLDPDTGLLRNLGPLDREA 652
+ + + + P + + + + ++ F++ TG+++ LDRE
Sbjct: 1641 GEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE- 1699
Query: 653 IDPALEGRIVLTVLVSDCGEPVL---GTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-D 708
+G + V V + + V IT++DINDN P+F + TV+E
Sbjct: 1700 -----QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIG 1754
Query: 709 PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVS--- 765
G + + A DAD+ GAN + ++ G A+ R+ P+
Sbjct: 1755 DGSKIMQLTAMDADE--------------GANALVTYTIISG---ADDSFRIDPESGDLI 1797
Query: 766 ----LDYETQPVFNLTVSAENPDPQGGETIVDVCVN--VKDVNDNPPTLDVASLRGIRVA 819
LD E + ++L V A++ G D+ +N V DVND+ P + +
Sbjct: 1798 ATRRLDRERRSKYSLLVRADD-----GLQSSDMRINITVSDVNDHTPKFS-RPVYSFDIP 1851
Query: 820 ENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQS 879
E+ VA ++A+D D+ EI + + G+ + G F N +
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVF----------NLT 1901
Query: 880 KAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIP 939
+ +DYE L VR A D G Q + + I DVNDN P F + + ++
Sbjct: 1902 RLLDYEVQQYYILTVR----AEDGGGQFTTIR--VYFNILDVNDNPPIFSLNSYSTSLME 1955
Query: 940 ELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFA 999
L + V D D G N + +SI D + G F++ +
Sbjct: 1956 NLPV-GSTVLVFNVTDADDGINSQLTYSIASGDSL----------GQFTVDKN------- 1997
Query: 1000 GSIQPVTSLDSTLQGTYQVTVQARDRPSL-GPFLEATTTLNLFTVDQSYRSRLQFSTPKE 1058
G ++ + +LD Q Y + VQ D P + +T +++ +D + + F +PK
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVN-DNPPTFLSPKL 2056
Query: 1059 EVGANRQAINAALTQATRTTVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSV 1118
I+ T V+ D DS P+SY++ + P G+ ++ +
Sbjct: 2057 TYIPENTPID--------TVVFKAQATDPDSG----PNSYIEYTLLNPLGNKFSIGTIDG 2104
Query: 1119 MIR-NDQDSLTQLLQLGLVVLGSQESQESDLSKQLISVII 1157
+R + ++ L V+ + + Q S S + V++
Sbjct: 2105 EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMV 2144
Score = 181 bits (458), Expect = 5e-45
Identities = 273/1049 (26%), Positives = 443/1049 (42%), Gaps = 135/1049 (12%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNAYFFAV 72
+V V NV P F + +PED P G + A D D + + G N+ F +
Sbjct: 2353 IVDDVNDNV-PTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ-FTI 2410
Query: 73 TPKTGEVKLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRNDNAPVFQNTA 128
P TG++ ++ LD ET + + + SD + +LV V D NDN P FQ+
Sbjct: 2411 NPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHP 2470
Query: 129 FSTSI-NETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVL 187
+ T I + TLP GS VF+V D D+G + YS+ S +SE G+I+
Sbjct: 2471 YVTHIPSPTLP-GSFVFAVTVTDADIGPNSELHYSL-----SGRNSEKFHIDPLRGAIMA 2524
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
G L+ ++ F + +K GG + T + +++ V++ D P+ + +
Sbjct: 2525 AGPLNGASEVTF-SVHVKD---GGSFPKTDS------TTVTVRFVNKADF-PKVRAKEQT 2573
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDRE 306
E+ + V T + G +P+ Y I+ F I G + ++ LD E
Sbjct: 2574 FMFPENQPVSSLVTT---ITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFE 2630
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
++ ++ + + A + + K+ I V+DVND+ P F
Sbjct: 2631 KI----QKYVVWIEARDGGFPPFSSYEKLDI----TVLDVNDNAPIF------------- 2669
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGS 426
+ F + E+ SPR LT+ D D G NG + + E S S A G
Sbjct: 2670 -KEDPFISEILENLSPR---KILTVSAMDKDSGPNGQLDYEIVNGNMEN-SFSINHATGE 2724
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATD--SVSQNFSVAMVTIHLRDINDHRPTFPQSL 484
+R +D E+ + + + ++D S SQ+ SV V I++ D ND+ P F Q +
Sbjct: 2725 ------IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSV-KVMINILDENDNAPRFSQ-I 2776
Query: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544
+ VPE+S G VT + +D D G YS++ + + F ++P +G + +
Sbjct: 2777 FSAHVPENSPLGYTVT-RVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVI--SR 2831
Query: 545 LLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVS-GSYNIFVQE--EEGNV 601
L+RE Y + + A D G + ST + I + DINDNAP S SY + E E G+
Sbjct: 2832 PLNREDTDRYRIRVSAHDSG-WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSK 2890
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE--- 658
+ A D DE G+N F Y F ++ TG + N L + +
Sbjct: 2891 VTQVFATDPDE-GSNGQVFYFIKSQSEY---FRINATTGEIFNKQILKYQNVTGFSNVNI 2946
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFT--VKEEDPGVLVGVV 716
R V SD G+P L ++ VTI + D NDN P F +S Y FT K G + V
Sbjct: 2947 NRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKY-FTPVTKNVKVGTKLIRV 3005
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
A D N+ + + +S N+ L GW L D++ + F +
Sbjct: 3006 TAIDDKDFGLNSEVEYFISND--NHLGKFKLDNDTGWISVASSLISDLNQN------FFI 3057
Query: 777 TVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836
TV+A++ + V + V + N + P + + + E+ S V V A D
Sbjct: 3058 TVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHM-SATIPESHSIGSIVRTVSARDR 3116
Query: 837 DTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRA 896
D + I K + G+ G F++ ++ + + +KA+DYE C + +
Sbjct: 3117 DAAMNGLI--------KYSISSGNE-EGIFAINSSTGI-LTLAKALDYELCQKHEMTIS- 3165
Query: 897 CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDD 956
A D G+ A + S+ + + DVNDN+P FL ++ F + E V + A D
Sbjct: 3166 ---AIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDD-YFPTVLENAPSGTTVIHLNATDA 3221
Query: 957 DSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVF-----AGSIQPVTSLDST 1011
DSG N VI +++ SS++D+F G I LD
Sbjct: 3222 DSGTNAVIAYTV----------------------QSSDSDLFVIDPNTGVITTQGFLDFE 3259
Query: 1012 LQGTYQVTVQARDRPSLGPFLEATTTLNL 1040
+ +Y +TV+A + P AT + L
Sbjct: 3260 TKQSYHLTVKAFNVPDEERCSFATVNIQL 3288
Score = 162 bits (410), Expect = 2e-39
Identities = 224/822 (27%), Positives = 333/822 (40%), Gaps = 120/822 (14%)
Query: 250 VAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQL 308
V E+ GT V T++ G ++ S F I + G + ++DRE L
Sbjct: 51 VLEEQPPGTLVGTIQTRPG---------FTYRLSESHALFAINSSTGALYTTSTIDRESL 101
Query: 309 LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEA 368
+ + L V ++ Y E V V V D+ND+ P F + P+ T +E
Sbjct: 102 --PSDVINLVVLSSAP---TYPTE------VRVLVRDLNDNAPVFPD---PSIVVTFKE- 146
Query: 369 QVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS---LGGPDAEAFSVSPE-RAA 424
D + ++ +D T D D GSNG S + G +A F + +
Sbjct: 147 --------DSSSGRQVILDTAT----DSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPS 194
Query: 425 GSASVQVLVRVSALVDYERQTAMAVQV---VATDSVSQNFSVAMVTIHLRDINDHRPTFP 481
G + LV L +R+ Q+ V + V + ++DIND+ P F
Sbjct: 195 GEGAFLHLVSKGGL---DREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFG 251
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
S Y VPE + GS V + A D D G I Y L + FQ+DP +G +TVR
Sbjct: 252 SSHYQAGVPEDAVVGSSVLQ-VAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVR 308
Query: 542 NGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSGSY--------N 591
E LD E++ Y LT+QA D G +L+ I LLD+NDN PVV Y +
Sbjct: 309 --EPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYAS 366
Query: 592 IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD----PDTGLLRNLGP 647
+ + G V + D D P N + + +L G +F + P+ L++
Sbjct: 367 VDENAQVGTVVALLTVTDADSPAANGN-ISVQILGGNEQRHFEVQSSKVPNLSLIKVASA 425
Query: 648 LDREAIDPALEGRIVLTVLVSD-CGEP------VLGTKVNVTITVEDINDNLPIFNQSSY 700
LDRE I P+ LTV VSD G P + ++ I V DIND+ P+F+Q Y
Sbjct: 426 LDRERI-PSYN----LTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVY 480
Query: 701 NFTVKEE-DPGVLVGVVKAWDADQ-TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL 758
+ EE PG V + A D D AN R S +SG+G +F I G +
Sbjct: 481 RVNLSEEAPPGSYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISE-------HSGLV 532
Query: 759 RLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRV 818
LD E L +SA + + + V + DVND P + V
Sbjct: 533 TTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSV 592
Query: 819 AENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQ 878
EN ++ ++ A+D D + V +A D S S ++
Sbjct: 593 VENAPTGTELLMLRATDGDLG---DNGTVRFSLQEAETDRRSFRLDPVSGR------LST 643
Query: 879 SKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVII 938
++D E +L+V A DL + P N SLL D+NDN+P F P + F I
Sbjct: 644 ISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLL----DINDNSPVFYPV-QYFAHI 698
Query: 939 PELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVF 998
E + +V A D D G NG + +SI D + F + S
Sbjct: 699 KENEPGGSYITTVSATDPDLGTNGTVKYSISAGD-----------RSRFQVNAQS----- 742
Query: 999 AGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNL 1040
G I +LD + YQ+ + A D +L +A T+ +
Sbjct: 743 -GVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/231 (26%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 15 VVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP----LTYGM-SGPNAYF 69
V + AN P F N+ SV + E +P+G ++ A D D+ P +Y + SG
Sbjct: 3393 VTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGA 3452
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQN 126
F++ P+TG++ + + LD ETL + +++ D P +LV +ED NDN P+
Sbjct: 3453 FSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML-- 3510
Query: 127 TAFSTSINETLPVGSVVFSVLAVDKDM-GSAGMVVYSIEKVIPSTGDSEHLFRILANGSI 185
T + E G++V ++ + D D+ + G Y + STG + F + G +
Sbjct: 3511 TVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTY----YLLSTGPATSYFSLSTAGVL 3566
Query: 186 VLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPD 236
+ + FY L + D G Q S + I+V+DQ D
Sbjct: 3567 STTREIDREQIADFY-LSVVTKDSG-------VPQMSSTGTVHITVIDQND 3609
>gi|16933565 protocadherin 21 precursor [Homo sapiens]
Length = 859
Score = 264 bits (674), Expect = 5e-70
Identities = 219/724 (30%), Positives = 336/724 (46%), Gaps = 66/724 (9%)
Query: 20 ANVAPKFL--------ANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMS--GPNAYF 69
AN AP F NM LPED PVG+ + L D + DP++Y +S
Sbjct: 21 ANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSV 80
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F+V P G + L LD E + IS+SD V +++++V D ND AP F +
Sbjct: 81 FSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPY 140
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH--LFRILANGSIVL 187
+ E +P GS++F V AVD+D GS G V Y ++ + H + R+ A
Sbjct: 141 VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQA------ 194
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
+L Y Y + + A D GG H + S ++++V D D+ P FV Y
Sbjct: 195 GATLDYERSRTHY-ITVVAKDGGGRLHGA-DVVFSATTTVTVNVEDVQDMAPVFVGTPYY 252
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQ 307
V ED G+ VL V A+DGD+G + ++YS+ G DG +N +
Sbjct: 253 GYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVN---------GNDGAFEINETSGAIS 303
Query: 308 LLEADEEVQLQVTATETHLNIY------GQEAKVSIWVTVRVMDVNDHKPEFYNCSLPAC 361
+ ++ ++Q +V E H+ + A+ ++ VT+R++D+N+H P FY S P
Sbjct: 304 ITQSPAQLQREV--YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGP-- 359
Query: 362 TFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421
Q F ++EH + L + V D D+G+N F L L GP F V P+
Sbjct: 360 -------QNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG-IFRVVPQ 411
Query: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNF-SVAMVTIHLRDINDHRPT 479
A V ++V SA +D+E+ + +++A + + + F S A V I L D ND+ P
Sbjct: 412 TVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPK 471
Query: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVT 539
F YV +PE++ GS V ++ A DPDTG WG++ YS G GADLF + P +G +
Sbjct: 472 FDSLYYVARIPENAPGGSSVV-AVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIY 529
Query: 540 VRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEG 599
+ LD E+ A Y ++A D S + I LLD+ND+ P S VQ++
Sbjct: 530 TQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKS----VQKKTM 585
Query: 600 --NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTG---LLRNLGPLDR-EAI 653
V I+A D D NN + +++ ++ F ++ TG L ++ LD I
Sbjct: 586 VLGTPVKIEAIDEDAEEPNN-LVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNI 644
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED-PGVL 712
P + L V D G P T + I DI D + F ++ +D P
Sbjct: 645 TPGRDCLWSLEVQAKDRGSPSFSTTALLKI---DITDAETLSRSPMAAFLIQTKDNPMKA 701
Query: 713 VGVV 716
VGV+
Sbjct: 702 VGVL 705
Score = 148 bits (374), Expect = 3e-35
Identities = 176/691 (25%), Positives = 297/691 (42%), Gaps = 87/691 (12%)
Query: 396 PDKGSNGTFLLSLGGPDAEAFSVS------PERAAGSASVQVLVRVSALVDYERQTAMAV 449
P+ G+ + +L G D E +S P + + ++ + + +R+ +
Sbjct: 45 PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEI 104
Query: 450 QVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPD 509
+ + + S N V I + D ND P F Q YV VPE GS++ +HA D D
Sbjct: 105 EAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF-KVHAVDRD 163
Query: 510 TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---- 565
TG+ G +TY L N F VD SG + ++ G LD E +Y+T+ A DGG
Sbjct: 164 TGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHG 221
Query: 566 ----LSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEE--GNVSVTIQAHDNDEPGTNNS 618
S++TT+ +++ D+ D APV G+ Y +V E+ G+ + + A D D N
Sbjct: 222 ADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPN-- 279
Query: 619 RLLFNLLPGPYSHNFSLDPDTGLL---RNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL 675
R+L++L+ G F ++ +G + ++ L RE + ++ +S G P
Sbjct: 280 RILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQ-----VTEMSPAGSPAA 333
Query: 676 GTKVNVTITVEDINDNLPIFN-----QSSYNFTVKEEDPG--VLVGV-VKAWDADQTEAN 727
V VTI + D+N++ P F Q+ + ++ E P +L G+ + D+DQ AN
Sbjct: 334 QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQG-AN 392
Query: 728 NRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA-ENPDPQ 786
+ + L G + ++ VL A+ + + ++D+E V + A E P+
Sbjct: 393 AKFNLQLVGPRGIFRVVPQTVLNE--AQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPE 450
Query: 787 GGETIVDVCVNVKDVNDNPPTLDVASLRGI-RVAENGSQHGQVAVVVASDVDTSAQLEIQ 845
+ DV + + D NDN P D SL + R+ EN V V A D DT E++
Sbjct: 451 KFSSTADVVIQLLDTNDNVPKFD--SLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
Query: 846 LVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF 905
G D+ + + G +Y ++D EA V+A D+
Sbjct: 509 YSTY---GTGADL------FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM------ 553
Query: 906 QAYSNNGSLLITIEDVNDNAPYF--LPENKTFVIIPELVLPNREVASVRARDDDSGN-NG 962
+ + + IT+ DVND+ P F + KT V+ + A D+D+ N
Sbjct: 554 EGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVL--------GTPVKIEAIDEDAEEPNN 605
Query: 963 VILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQG---TYQVT 1019
++ +SI + + VF I + + SI+ + +L + G + +
Sbjct: 606 LVDYSITHAEPAN----------VFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLE 655
Query: 1020 VQARDRPSLGPFLEATTTLNLFTVDQSYRSR 1050
VQA+DR S P T L + D SR
Sbjct: 656 VQAKDRGS--PSFSTTALLKIDITDAETLSR 684
Score = 125 bits (315), Expect = 2e-28
Identities = 161/592 (27%), Positives = 257/592 (43%), Gaps = 94/592 (15%)
Query: 249 SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISY--STRPGWFDIGADGVIRVNGSLDRE 306
S+ ED G+ V T+ D + DP+ Y IS+ STR + G I + LDRE
Sbjct: 43 SLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
+ ++E++ ++ ++ LN+ ++ V + V D ND P F P PE
Sbjct: 100 R----EDEIEAIISISDG-LNLVAEK------VVILVTDANDEAPRFIQ--EPYVALVPE 146
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVY--DPDKGSNGT---FLLSLGGPDAEAFSVSPE 421
+ IP + V+ D D GS G+ FL +L P F+V +
Sbjct: 147 D----------------IPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP----FAV--D 184
Query: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF-------SVAMVTIHLRDIN 474
R +G +Q A +DYER + VVA D + + VT+++ D+
Sbjct: 185 RHSGVLRLQA----GATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240
Query: 475 DHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPV 534
D P F + Y V E + GS V + A D D G +I YSL+ GN F+++
Sbjct: 241 DMAPVFVGTPYYGYVYEDTLPGSEVLKVV-AMDGDRGKPNRILYSLVNGNDG-AFEINET 298
Query: 535 SGTVTVRNGEL-LDRESQAVYYLTLQATDGGNLSSSTTLQ--IHLLDINDNAPVVSGS-- 589
SG +++ L RE ++ + + G+ ++ T+ I ++D+N++ P G
Sbjct: 299 SGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESG 358
Query: 590 ----YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNL-LPGPYSHNFSLDPDTGLL 642
+ + + E +G + ++ ND N++ FNL L GP F + P T L
Sbjct: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK--FNLQLVGPRGI-FRVVPQTVLN 415
Query: 643 RNLGPLDRE---AIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQS 698
+ E AID + +L + P + +V I + D NDN+P F+
Sbjct: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
Query: 699 SYNFTVKEEDPG-VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIR---GLVLGAGWA 754
Y + E PG V V A D D T + +S G+GA+ F+I GL+ WA
Sbjct: 476 YYVARIPENAPGGSSVVAVTAVDPD-TGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWA 534
Query: 755 EGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
SLD E +N V AE D +G ++ +V + + DVND+PP
Sbjct: 535 ----------SLDAEATARYNFYVKAE--DMEGKYSVAEVFITLLDVNDHPP 574
Score = 107 bits (266), Expect = 1e-22
Identities = 145/605 (23%), Positives = 254/605 (41%), Gaps = 86/605 (14%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF---- 69
++V+ A + AP+F+ ++PED+P G+ F + A D+D G G YF
Sbjct: 123 ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDT-----GSGGSVTYFLQNL 177
Query: 70 ---FAVTPKTGEVKL--ASALDYETLYTFKVTISV---------SDPYIQVQREMLVIVE 115
FAV +G ++L + LDYE T +T+ +D + V VE
Sbjct: 178 HSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVE 237
Query: 116 DRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
D D APVF T + + E GS V V+A+D D G ++YS+ ++
Sbjct: 238 DVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSL------VNGNDG 291
Query: 176 LFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ 234
F I +G+I + S + + Y+L ++ ++ + Q ++PV +I +VD
Sbjct: 292 AFEINETSGAISITQSPAQLQREV-YELHVQVTEMSPA--GSPAAQATVPV--TIRIVDL 346
Query: 235 PDLDPQFVREF-----YSASVAEDAAKGTSV--LTVEAVDGDKGINDPVIYSISYSTRPG 287
+ P F E + S+ E +G + L + D D+G N +++ G
Sbjct: 347 NNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN--AKFNLQLVGPRG 404
Query: 288 WFDIGADGVI---RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVM 344
F + V+ +V ++ ++ ++ L +N ++ + V ++++
Sbjct: 405 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNT-PEKFSSTADVVIQLL 463
Query: 345 DVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTF 404
D ND+ P+F + + + E+A + +T V DPD G G
Sbjct: 464 DTNDNVPKF--------------DSLYYVARIPENAPGGSSVVAVTAV--DPDTGPWGEV 507
Query: 405 LLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVA 464
S G A+ F + P + + A +D E TA V + + +SVA
Sbjct: 508 KYSTYGTGADLFLIHPSTGL------IYTQPWASLDAE-ATARYNFYVKAEDMEGKYSVA 560
Query: 465 MVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQ-ITYSLLPG 523
V I L D+NDH P F +S+ T+ G+ V I A D D + YS+
Sbjct: 561 EVFITLLDVNDHPPQFGKSVQKKTM----VLGTPV--KIEAIDEDAEEPNNLVDYSITHA 614
Query: 524 NGADLFQVDPVSGTVTVRNG-------ELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL 576
A++F ++ +G + ++N + ++ L +QA D G+ S STT +
Sbjct: 615 EPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLK- 673
Query: 577 LDIND 581
+DI D
Sbjct: 674 IDITD 678
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 254 bits (649), Expect = 4e-67
Identities = 293/1043 (28%), Positives = 464/1043 (44%), Gaps = 120/1043 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQDND---PLTYGMSGPNAYFFAVTPKTGEV 79
+P FL N V L E+ P+ + D D+ +TY + A + G++
Sbjct: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQI 2548
Query: 80 KLASALDYETLY--TFKVTISVSDPYIQVQR-EMLVIVEDRNDNAPVFQNTAFSTSINET 136
LD ET V + D +V + VI+ D NDNAP F+ T + +I +
Sbjct: 2549 FTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSS 2608
Query: 137 LPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNK 196
G+ V VLA D D GS + Y+IE S ++ + ++ +G I SL +
Sbjct: 2609 AAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKL--SGVITTKESL-IGLE 2665
Query: 197 SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAK 256
+ F+ ++A D G + V + + ++ P+F FY+ +V+ED
Sbjct: 2666 NEFFTFFVRAVDNGSPSKESV-------VLVYVKILPPEMQLPKFSEPFYTFTVSEDVPI 2718
Query: 257 GTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLL--EADEE 314
GT + + A + V+YS+ P + + R +G L E+ L E +
Sbjct: 2719 GTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKW 2773
Query: 315 VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV--NF 372
Q + A T + E S+ V+++V D ND+ P F + +P EA + N
Sbjct: 2774 YQFSILARCTQDD---HEMVASVDVSIQVKDANDNSPVFES--------SPYEAFIVENL 2822
Query: 373 TGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDA----EAFSVSPERAAGSAS 428
G R+ + + D D G+NG + SL + E+F+++ E
Sbjct: 2823 PG------GSRV----IQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETG----- 2867
Query: 429 VQVLVRVSALVDYERQTAMAVQVVATD--SVSQNFSVAMVTIHLRDINDHRPTFPQSLYV 486
+ +D+E++ ++VVA+D Q S A+V + + D+ND P F +Y
Sbjct: 2868 ---WITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYK 2924
Query: 487 LTVPEHSATGSVVTDSIHATDPDTGAWG-QITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
TV E G V+ + TD D+ Q+TY + G+ F V+ + V +
Sbjct: 2925 GTVSEDDPQGGVIA-ILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKP 2983
Query: 546 LDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSVT 604
LDRE + Y LT+ ATD G SS +++ +LD NDN+PV + Y+ + E+ +
Sbjct: 2984 LDREKRDNYLLTITATD-GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLI 3042
Query: 605 IQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLT 664
+Q D +N+ + + LL G + F L+PDTG L+ PLDRE + L
Sbjct: 3043 MQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREE-----QAVYHLL 3096
Query: 665 VLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQ 723
V +D G + ++ +T+ED+NDN P F+ Y TV E +PG L+ V+A DAD
Sbjct: 3097 VRATDGGGRF--CQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD- 3153
Query: 724 TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENP 783
N +I +SL S F I L G ++L + LD E Q V+ L++ A +
Sbjct: 3154 AGLNRKILYSLIDSADGQFSINEL-------SGIIQL--EKPLDRELQAVYTLSLKAVDQ 3204
Query: 784 D-PQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
P+ V V+V D+NDNPP + G V+E+ +V V A+ D A
Sbjct: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREY-GATVSEDILVGTEVLQVYAASRDIEANA 3263
Query: 843 EIQLVNILCTKAGVDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLVTLVVRACDLAT 901
EI I + G FS+ + G+V+I ++ +DYE+ L V AT
Sbjct: 3264 EITYSIISGNEHGK---------FSIDSKTGAVFIIEN--LDYESSHEYYLTVE----AT 3308
Query: 902 DPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNN 961
D G + S+ ++ + + D+NDN P F + T VI + VL + V +V A D D +N
Sbjct: 3309 DGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVL-EQSVITVMADDADGPSN 3367
Query: 962 GVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQ 1021
I +SI+ DG QG +S D G ++ LD Y +TVQ
Sbjct: 3368 SHIHYSII-------DGN----QG-----SSFTIDPVRGEVKVTKLLDRETISGYTLTVQ 3411
Query: 1022 ARDRPSLGPFLEATTTLNLFTVD 1044
A D S P TTT+N+ D
Sbjct: 3412 ASDNGS--PPRVNTTTVNIDVSD 3432
Score = 242 bits (618), Expect = 1e-63
Identities = 241/842 (28%), Positives = 381/842 (45%), Gaps = 98/842 (11%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA------YFFAVTPKTG 77
PKF + + ED+P+G + + AE + Y + N F + ++G
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGT--VLYSLVKGNTPESNRDESFVIDRQSG 2758
Query: 78 EVKLASALDYETLYTFKVTI----SVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSI 133
+KL +LD+ET ++ +I + D + ++ + V+D NDN+PVF+++ + I
Sbjct: 2759 RLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFI 2818
Query: 134 NETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSY 193
E LP GS V + A D D G+ G V+YS+++ S E + G I L +
Sbjct: 2819 VENLPGGSRVIQIRASDADSGTNGQVMYSLDQ-SQSVEVIESFAINMETGWITTLKELDH 2877
Query: 194 NNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAED 253
+ YQ+++ A D G IQ S + ++V D D P+F E Y +V+ED
Sbjct: 2878 EKRDN-YQIKVVASDHGE------KIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSED 2930
Query: 254 AAKGTSVLTVEAVDGD-KGINDPVIYSISYSTRPGWF---DIGADGVIRVNGSLDREQLL 309
+G + + D D + IN V Y I+ G F I + + V LDRE+
Sbjct: 2931 DPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREK-- 2988
Query: 310 EADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQ 369
+ L +TAT+ G + +I V V+V+D ND+ P C T
Sbjct: 2989 --RDNYLLTITATD------GTFSSKAI-VEVKVLDANDNS--------PVCEKT----- 3026
Query: 370 VNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASV 429
++ + E P I ++ D D SN +L G AE F ++P+
Sbjct: 3027 -LYSDTIPEDVLPGKLIMQISAT--DADIRSNAEITYTLLGSGAEKFKLNPDTGE----- 3078
Query: 430 QVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTV 489
++ S +D E Q + V ATD F A + + L D+ND+ P F Y +TV
Sbjct: 3079 ---LKTSTPLDREEQAVYHLLVRATDG-GGRFCQASIVLTLEDVNDNAPEFSADPYAITV 3134
Query: 490 PEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGAD-LFQVDPVSGTVTVRNGELLDR 548
E++ G+++T + ATD D G +I YSL+ + AD F ++ +SG + + + LDR
Sbjct: 3135 FENTEPGTLLT-RVQATDADAGLNRKILYSLI--DSADGQFSINELSGIIQLE--KPLDR 3189
Query: 549 ESQAVYYLTLQATDGG---NLSSSTTLQIHLLDINDNAPVVS-GSYNIFVQEEEGNVSVT 604
E QAVY L+L+A D G L+++ T+ + +LDINDN PV Y V E+ +
Sbjct: 3190 ELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEV 3249
Query: 605 IQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLT 664
+Q + N+ + ++++ G FS+D TG + + LD E+ LT
Sbjct: 3250 LQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYES-----SHEYYLT 3304
Query: 665 VLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL---VGVVKAWDA 721
V +D G P L V + V DINDN P+F+Q +Y + E+ VL V V A DA
Sbjct: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISED--AVLEQSVITVMADDA 3362
Query: 722 DQTEANNRISFSL----SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT 777
D +N+ I +S+ GS +RG + LD ET + LT
Sbjct: 3363 D-GPSNSHIHYSIIDGNQGSSFTIDPVRG------------EVKVTKLLDRETISGYTLT 3409
Query: 778 VSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
V A + V ++V DVNDN P + + + EN V +V +D D
Sbjct: 3410 VQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNY-SVIIQENKPVGFSVLQLVVTDED 3468
Query: 838 TS 839
+S
Sbjct: 3469 SS 3470
Score = 238 bits (607), Expect = 3e-62
Identities = 290/1057 (27%), Positives = 445/1057 (42%), Gaps = 146/1057 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P F+ V + EDLP G WL A D D + + Y + F V +G V+
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVR 984
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREMLVIVE----DRNDNA--PVFQNTAFSTSIN 134
+ LD+E + +T+ D V VE D N+N PVF + ++
Sbjct: 985 IVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVK 1044
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYN 194
E PVGS+V +V A D+D G + YSI G +F+I ++
Sbjct: 1045 EDAPVGSLVMTVSAHDEDARRDGEIRYSIRD-----GSGVGVFKIGEETGVIETSDRLDR 1099
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
++ Y L + A D G + ++F + + I V D D PQ Y + E++
Sbjct: 1100 ESTSHYWLTVFATDQGVVPLSSF-------IEIYIEVEDVNDNAPQTSEPVYYPEIMENS 1152
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNG-SLDREQLLEAD 312
K SV+ +EA D D ND ++Y I+ G+F I G+I LDREQ D
Sbjct: 1153 PKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQ---QD 1209
Query: 313 EEVQLQVTATETHLNIYGQEAKVSIW-VTVRVMDVNDHKPEF----YNCSLPACTFTPEE 367
E + L+VT T+ G K +I V V+++D ND+KP+F Y LP E
Sbjct: 1210 EHI-LEVTVTDN-----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRE 1263
Query: 368 AQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGS 426
R P+ ++ D D+G N S+ G + F + P+ S
Sbjct: 1264 RNAR-----------REPL--YHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS 1310
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT-----FP 481
+ R SA +Y+ + + A D+ S + +H+ I+ +P+ F
Sbjct: 1311 SK-----RFSAAGEYD-----ILSIKAVDNGRPQKS-STTRLHIEWISKPKPSLEPISFE 1359
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+S + TV E ++ I P W IT GN F VD +GT+ V
Sbjct: 1360 ESFFTFTVMESDPVAHMI-GVISVEPPGIPLWFDIT----GGNYDSHFDVDKGTGTIIV- 1413
Query: 542 NGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGN 600
+ LD E ++ Y LT++ATDG + T + I ++D ND+ P S S Y + + E+
Sbjct: 1414 -AKPLDAEQKSNYNLTVEATDG-TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAP 1471
Query: 601 VSVTIQ--AHDNDEPGTNNSRLLFNLLPG--PYS-HNFSLDPDTGLLRNLGPLDREAIDP 655
+ +Q A D DE ++L++ L P S F LDP TG L LD EA+
Sbjct: 1472 ETEILQISAVDQDE----KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH- 1526
Query: 656 ALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVG 714
+ LTV+V D PV + + V D ND+ P F SSY V E G +V
Sbjct: 1527 ----QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
Query: 715 VVKAWDADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPV 773
V A D D+ + N + +S+ SG+ N FMI VLG+ + LD Q
Sbjct: 1583 QVTALDKDKGK-NAEVLYSIESGNIGNSFMIDP-VLGS--------IKTAKELDRSNQAE 1632
Query: 774 FNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVA 833
++L V A + I V + V + DN + + ++E S V +V A
Sbjct: 1633 YDLMVKATDKGSPPMSEITSVRIFVT-IADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
Query: 834 SDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLV 893
+S EI+ N G F + + I Q KA+D+E + TL+
Sbjct: 1692 HS-QSSVVYEIKDGN---------TGDA----FDINPHSGTIITQ-KALDFETLPIYTLI 1736
Query: 894 VRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVI-----IPELVLPNREV 948
++ ++A S N ++L+ ++D NDNAP F+ T +I I +VL +R V
Sbjct: 1737 IQGTNMA------GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNV 1790
Query: 949 ASV-RARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTS 1007
V RA D D +N ++++ I+ S+ T D G+I V S
Sbjct: 1791 PLVIRAADADKDSNALLVYHIVEP----------------SVHTYFAIDSSTGAIHTVLS 1834
Query: 1008 LDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
LD + TVQ D + F E + + +D
Sbjct: 1835 LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVID 1871
Score = 224 bits (572), Expect = 3e-58
Identities = 276/1053 (26%), Positives = 451/1053 (42%), Gaps = 135/1053 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYF---FAVTPKT 76
AP+F A V + G ++A D D N +TY + + + +
Sbjct: 2593 APQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLS 2652
Query: 77 GEVKLASAL---DYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSI 133
G + +L + E F + P + + V + P F ++ ++
Sbjct: 2653 GVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTV 2712
Query: 134 NETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKV-IPSTGDSEHLFRILANGSIVLNGSLS 192
+E +P+G+ + + A +G V+YS+ K P + E +G + L SL
Sbjct: 2713 SEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLD 2767
Query: 193 YNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
+ + +YQ + L + + S+ V SI V D D P F Y A + E
Sbjct: 2768 HET-TKWYQFSI----LARCTQDDHEMVASVDV--SIQVKDANDNSPVFESSPYEAFIVE 2820
Query: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA----DGVIRVNGSLDREQL 308
+ G+ V+ + A D D G N V+YS+ S + A G I LD E+
Sbjct: 2821 NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR 2880
Query: 309 LEADEEVQLQVTATETHLNIYGQEAKVSIW--VTVRVMDVNDHKPEFYNCSLPACTFTPE 366
+ Q++V A++ +G++ ++S V V V DVND P F
Sbjct: 2881 ----DNYQIKVVASD-----HGEKIQLSSTAIVDVTVTDVNDSPPRF------------- 2918
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGS 426
A++ + G V E I L+ D ++ + GG F+V +
Sbjct: 2919 TAEI-YKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVE------T 2971
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYV 486
+ V V +D E++ + + ATD S A+V + + D ND+ P ++LY
Sbjct: 2972 IQNEWKVYVKKPLDREKRDNYLLTITATDGTFS--SKAIVEVKVLDANDNSPVCEKTLYS 3029
Query: 487 LTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELL 546
T+PE G ++ I ATD D + +ITY+LL G+GA+ F+++P +G + + L
Sbjct: 3030 DTIPEDVLPGKLIMQ-ISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGEL--KTSTPL 3085
Query: 547 DRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSV 603
DRE QAVY+L ++ATDGG ++ + L D+NDNAP S + +F E G +
Sbjct: 3086 DREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLT 3145
Query: 604 TIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVL 663
+QA D D N ++L++L+ FS++ +G+++ PLDRE L+ L
Sbjct: 3146 RVQATDAD--AGLNRKILYSLIDSA-DGQFSINELSGIIQLEKPLDRE-----LQAVYTL 3197
Query: 664 TVLVSDCGEPVLGTKVN-VTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVG--VVKAWD 720
++ D G P T V ++V DINDN P+F Y TV E+ +LVG V++ +
Sbjct: 3198 SLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSED---ILVGTEVLQVYA 3254
Query: 721 ADQT-EANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTV 778
A + EAN I++S+ SG+ F I E +LDYE+ + LTV
Sbjct: 3255 ASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIE---------NLDYESSHEYYLTV 3305
Query: 779 SAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDT 838
A + + V VNV D+NDN P + + ++E+ V V+A D D
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV-ISEDAVLEQSVITVMADDADG 3364
Query: 839 SAQLEIQLVNILCTKAGVDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLVTLVVRAC 897
+ I +I+ G F++ G V + +K +D E TL V+A
Sbjct: 3365 PSNSHIHY-SIIDGNQGSS--------FTIDPVRGEVKV--TKLLDRETISGYTLTVQAS 3413
Query: 898 DLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDD 957
D + P N ++ I + DVNDNAP F N + VII E V + D+D
Sbjct: 3414 DNGSPPRV----NTTTVNIDVSDVNDNAPVFSRGNYS-VIIQENKPVGFSVLQLVVTDED 3468
Query: 958 SGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTL----Q 1013
S +NG F F+I T ++ F + Q V S + +
Sbjct: 3469 SSHNGPPFF--------------------FTIVTGNDEKAFEVNPQGVLLTSSAIKRKEK 3508
Query: 1014 GTYQVTVQARDRPSLGPFLEATTTLNLFTVDQS 1046
Y + V+ D P L + T +++ +++S
Sbjct: 3509 DHYLLQVKVADNGK--PQLSSLTYIDIRVIEES 3539
Score = 212 bits (539), Expect = 2e-54
Identities = 247/951 (25%), Positives = 407/951 (42%), Gaps = 108/951 (11%)
Query: 63 SGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAP 122
S P F++ TG + + + + F++ ++ SD + ++LV V N N P
Sbjct: 404 STPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR--KASTKVLVKVLGANSNPP 461
Query: 123 VFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN 182
F TA+ + +E +P+G+ V S+ AVD D G G V YSI + +H
Sbjct: 462 EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHF-----T 516
Query: 183 GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242
G++ + +L Y Y L ++A D G Y + V +I++ + D P F
Sbjct: 517 GAVSTSENLDYELMPRVYTLRIRASDWGLPYRR------EVEVLATITLNNLNDNTPLFE 570
Query: 243 REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNG 301
+ ++ D G + TV A+D D+ V Y I +F + + GV+ +
Sbjct: 571 KINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFSLNPNSGVLSLKR 628
Query: 302 SL----------DREQLLEADEE-------VQLQVTATETHLNIYGQEAKVSIWVTVRVM 344
SL ++ D E + + V A+ +N+ +E V+ + +++
Sbjct: 629 SLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLL 688
Query: 345 DVN-----DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKG 399
N + + S P+ TG + P + + M D D G
Sbjct: 689 QANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP-VGSSVIFMNSTDLDTG 747
Query: 400 SNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SV 457
NG + ++ GG + F + E ++++ + +D E + + D +
Sbjct: 748 FNGKLVYAVSGGNEDSCFMIDMETG--------MLKILSPLDRETTDKYTLNITVYDLGI 799
Query: 458 SQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQIT 517
Q + ++ + + D ND+ P F Q Y + V E S + + ATD D G G +T
Sbjct: 800 PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-QVEATDKDLGPNGHVT 858
Query: 518 YSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG----NLSSSTTLQ 573
YS++ D F +D V+G V + LDRE Q + L ++A D L S+ ++
Sbjct: 859 YSIV--TDTDTFSIDSVTGVVNI--ARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVK 914
Query: 574 IHLLDINDNAPV-VSGSYNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYS 630
+ L D+NDN P + +Y + V+E+ EG V + ++AHD D + R ++LL
Sbjct: 915 VSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR--YSLLDHG-E 971
Query: 631 HNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDIN 689
NF +D +G +R + LD E + LTV D G+PV L + V + V D+N
Sbjct: 972 GNFDVDKLSGAVRIVQQLDFEK-----KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVN 1026
Query: 690 DNL--PIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSL-SGSGANYFMIR 745
+NL P+F+ TVKE+ P G LV V A D D + I +S+ GSG F I
Sbjct: 1027 ENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDED-ARRDGEIRYSIRDGSGVGVFKI- 1084
Query: 746 GLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP 805
G G + LD E+ + LTV A + + +++ + V+DVNDN
Sbjct: 1085 ------GEETGVIETSD--RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNA 1136
Query: 806 PTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGW 865
P + + EN + V + A D D+S+ ++ + G+ G+
Sbjct: 1137 PQTS-EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY--------KITSGN-PQGF 1186
Query: 866 FSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNA 925
FS+ + S+ +D E D L V TD G S +++ I D NDN
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEV----TVTDNGSPPKSTIARVIVKILDENDNK 1242
Query: 926 PYFLPENKTFVI-IPELVLPNRE-------VASVRARDDDSGNNGVILFSI 968
P FL K + I +PE P+RE + V A D D G N I +SI
Sbjct: 1243 PQFL--QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSI 1291
Score = 207 bits (528), Expect = 4e-53
Identities = 235/888 (26%), Positives = 385/888 (43%), Gaps = 128/888 (14%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P+F E++P+G L A D D N +TY ++ N FA+ TG V
Sbjct: 461 PEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVS 520
Query: 81 LASALDYETL-YTFKVTISVSDPYIQVQREMLVI----VEDRNDNAPVFQNTAFSTSINE 135
+ LDYE + + + I SD + +RE+ V+ + + NDN P+F+ +I
Sbjct: 521 TSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPR 580
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN-GSIVLNGSL--S 192
L VG + +V A+D D +V Y IE G+ F + N G + L SL
Sbjct: 581 DLGVGEQITTVSAIDAD--ELQLVQYQIE-----AGNELDFFSLNPNSGVLSLKRSLMDG 633
Query: 193 YNNKSAFYQLELKACD------------LGGMYHNTFTIQC---SLPVFLSISVVDQPDL 237
K +F+ L + A D H +QC + L+ ++ L
Sbjct: 634 LGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKL 693
Query: 238 DPQ---------------FVREFYSA-----SVAEDAAKGTSVLTVEAVDGDKGINDPVI 277
Q + +F S V E+ G+SV+ + + D D G N ++
Sbjct: 694 HNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLV 753
Query: 278 YSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVS 336
Y++S F I + G++++ LDR E ++ L +T + + Q+A
Sbjct: 754 YAVSGGNEDSCFMIDMETGMLKILSPLDR----ETTDKYTLNITVYDLGI---PQKAAWR 806
Query: 337 IWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDP 396
+ + V V+D ND+ PEF S +V+ + + + + D
Sbjct: 807 L-LHVVVVDANDNPPEFLQESY----------------FVEVSEDKEVHSEIIQVEATDK 849
Query: 397 DKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS 456
D G NG S+ D + FS+ SV +V ++ +D E Q ++++ A D
Sbjct: 850 DLGPNGHVTYSI-VTDTDTFSID--------SVTGVVNIARPLDRELQHEHSLKIEARDQ 900
Query: 457 V---SQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAW 513
Q FS +V + L D+ND+ PTF Y + V E G+V+ + A DPD G
Sbjct: 901 AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIM-WLEAHDPDLGQS 959
Query: 514 GQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG---NLSSST 570
GQ+ YSLL +G F VD +SG VR + LD E + VY LT++A D G +LSS+
Sbjct: 960 GQVRYSLL-DHGEGNFDVDKLSG--AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTC 1016
Query: 571 TLQIHLLDINDN--APVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNNSRLLFNLL 625
+++ ++D+N+N PV S +E+ G++ +T+ AHD D + + +++
Sbjct: 1017 YVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIR 1074
Query: 626 PGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITV 685
G F + +TG++ LDRE+ LTV +D G L + + + I V
Sbjct: 1075 DGSGVGVFKIGEETGVIETSDRLDRES-----TSHYWLTVFATDQGVVPLSSFIEIYIEV 1129
Query: 686 EDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSL-SGSGANYFM 743
ED+NDN P ++ Y + E P V V ++A+D D + +N+++ + + SG+ +F
Sbjct: 1130 EDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPD-SSSNDKLMYKITSGNPQGFFS 1188
Query: 744 IRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVND 803
I + L LD E Q L V+ + TI V V + D ND
Sbjct: 1189 IH--------PKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
Query: 804 NPPTLDVASLRGIRV-------AENGSQHGQVAVVVASDVDTSAQLEI 844
N P + IR+ E ++ + V+A+D D EI
Sbjct: 1241 NKPQF-LQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEI 1287
Score = 203 bits (517), Expect = 8e-52
Identities = 212/769 (27%), Positives = 347/769 (45%), Gaps = 98/769 (12%)
Query: 3 QLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD----NDPL 58
++ LS + + V+ + P+F A + + ED P G L D D N +
Sbjct: 2895 KIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQV 2954
Query: 59 TYGMSG--PNAYFFAVT-PKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVE 115
TY ++G P F T +V + LD E + +TI+ +D + + V V
Sbjct: 2955 TYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVL 3014
Query: 116 DRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
D NDN+PV + T +S +I E + G ++ + A D D+ S + Y++ G
Sbjct: 3015 DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL------LGSGAE 3068
Query: 176 LFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQP 235
F++ + + + + A Y L ++A D GG + C + L++ D
Sbjct: 3069 KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRF-------CQASIVLTLE--DVN 3119
Query: 236 DLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-AD 294
D P+F + Y+ +V E+ GT + V+A D D G+N ++YS+ + G F I
Sbjct: 3120 DNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELS 3178
Query: 295 GVIRVNGSLDRE-------QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
G+I++ LDRE L D+ + ++TAT T V V V+D+N
Sbjct: 3179 GIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGT--------------VIVSVLDIN 3224
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F A T E + T + +A+ R D + + T+ +
Sbjct: 3225 DNPPVFEYREYGA---TVSEDILVGTEVLQVYAASR-----------DIEANAEITYSI- 3269
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMV 466
+ G + FS+ + A V + +DYE + V ATD + + S VA V
Sbjct: 3270 ISGNEHGKFSIDSKTGA--------VFIIENLDYESSHEYYLTVEATDGGTPSLSDVATV 3321
Query: 467 TIHLRDINDHRPTFPQSLYVLTVPEHSA-TGSVVTDSIHATDPDTGAWGQITYSLLPGNG 525
+++ DIND+ P F Q Y + E + SV+T + A D D + I YS++ GN
Sbjct: 3322 NVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVIT--VMADDADGPSNSHIHYSIIDGNQ 3379
Query: 526 ADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNA 583
F +DPV G V V +LLDRE+ + Y LT+QA+D G+ ++TT+ I + D+NDNA
Sbjct: 3380 GSSFTIDPVRGEVKVT--KLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNA 3437
Query: 584 PVVS-GSYNIFVQEEEGNVSVTIQAHDNDEPGTNNS-RLLFNLLPGPYSHNFSLDPDTGL 641
PV S G+Y++ +QE + +Q DE ++N F ++ G F ++P L
Sbjct: 3438 PVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVL 3497
Query: 642 LRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG--TKVNVTITVEDIND----NLPIF 695
L + AI + +L V V+D G+P L T +++ + E I L IF
Sbjct: 3498 LTS------SAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIF 3551
Query: 696 NQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMI 744
SS EE G ++G + A D D + +++SL N F +
Sbjct: 3552 ITSS-----GEEYSGGVIGKIHATDQD---VYDTLTYSLDPQMDNLFSV 3592
Score = 201 bits (512), Expect = 3e-51
Identities = 257/976 (26%), Positives = 409/976 (41%), Gaps = 113/976 (11%)
Query: 10 LLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMSGPN 66
LL +VV N P+FL V + ED V ++ + A D+D P +TY + +
Sbjct: 807 LLHVVVVDANDN-PPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV-TD 864
Query: 67 AYFFAVTPKTGEVKLASALDYETLYTFKVTISVSD-----PYIQVQREMLVIVEDRNDNA 121
F++ TG V +A LD E + + I D P + + V +ED NDN
Sbjct: 865 TDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNP 924
Query: 122 PVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA 181
P F + + E LP G+V+ + A D D+G +G V YS+ D + L
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKL----- 979
Query: 182 NGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD-QPDLDPQ 240
+G++ + L + K Y L ++A D G + S ++ + VVD +L P
Sbjct: 980 SGAVRIVQQLDFEKKQV-YNLTVRAKDKGK------PVSLSSTCYVEVEVVDVNENLHPP 1032
Query: 241 FVREFYS-ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIR 298
F +V EDA G+ V+TV A D D + + YSI + G F IG + GVI
Sbjct: 1033 VFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIE 1092
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+ LDRE + L V AT+ + + + I++ V DVND+ P+ S
Sbjct: 1093 TSDRLDRE----STSHYWLTVFATDQ--GVVPLSSFIEIYIEVE--DVNDNAPQ---TSE 1141
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAF-S 417
P + PE + SP+ + + + +DPD SN + + + + F S
Sbjct: 1142 PV--YYPEIME----------NSPK-DVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFS 1188
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDH 476
+ P+ ++ S +D E+Q ++V TD+ S S +A V + + D ND+
Sbjct: 1189 IHPKTG-------LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDN 1241
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDS------IHATDPDTGAWGQITYSLLPGNGADLFQ 530
+P F Q Y + +PE + ATD D G +I+YS+ GN F
Sbjct: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF 1301
Query: 531 VDPVSGTVTVRNGELLDRESQAVYY--LTLQATDGGNLSSSTTLQIHLLDINDNAPVV-- 586
++P +G V+ + R S A Y L+++A D G S+T ++H+ I+ P +
Sbjct: 1302 IEPKTGVVSSK------RFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
Query: 587 ---SGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLR 643
S+ F E V+ I + PG L F++ G Y +F +D TG +
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGI---PLWFDITGGNYDSHFDVDKGTGTII 1412
Query: 644 NLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFT 703
PLD E + LTV +D +L V I V D ND+ P F+ S Y
Sbjct: 1413 VAKPLDAEQ-----KSNYNLTVEATDGTTTIL---TQVFIKVIDTNDHRPQFSTSKYEVV 1464
Query: 704 VKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPP 762
+ E+ P + + A D D+ N++ ++L S + ++ L Y
Sbjct: 1465 IPEDTAPETEILQISAVDQDE---KNKLIYTLQ-SSRDPLSLKKFRLDPATGSLY----T 1516
Query: 763 DVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENG 822
LD+E LTV + D + VNV D ND+ P +S +G RV E+
Sbjct: 1517 SEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG-RVYESA 1575
Query: 823 SQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAI 882
+ V V A D D E+ ++ G++ + GS I +K +
Sbjct: 1576 AVGSVVLQVTALDKDKGKNAEVLY--------SIESGNIGNSFMIDPVLGS--IKTAKEL 1625
Query: 883 DYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELV 942
D L+V+ ATD G S S+ I + ++ +P F + + V + E V
Sbjct: 1626 DRSNQAEYDLMVK----ATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYS-VELSETV 1680
Query: 943 LPNREVASVRARDDDS 958
V V A S
Sbjct: 1681 SIGSFVGMVTAHSQSS 1696
Score = 197 bits (501), Expect = 5e-50
Identities = 256/971 (26%), Positives = 411/971 (42%), Gaps = 128/971 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDN-DPLTYGMSGPNAYF----FAVTPKTGE 78
P+F + V++PED + + A DQD + L Y + F + P TG
Sbjct: 1454 PQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGS 1513
Query: 79 VKLASALDYETLYTFKVTISVSDPYIQVQRE---MLVIVEDRNDNAPVFQNTAFSTSINE 135
+ + LD+E ++ +T+ V D + V+R ++V V D ND+AP F +++ + E
Sbjct: 1514 LYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYE 1573
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNN 195
+ VGSVV V A+DKD G V+YSIE + G+S + +L GSI L +N
Sbjct: 1574 SAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNSFMIDPVL--GSIKTAKELDRSN 1629
Query: 196 KSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAA 255
+ A Y L +KA D G + T S+ +F++I+ + P+F + YS ++E +
Sbjct: 1630 Q-AEYDLMVKATDKGSPPMSEIT---SVRIFVTIA----DNASPKFTSKEYSVELSETVS 1681
Query: 256 KGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEE 314
G+ V V A V+Y I FDI G I +LD E L
Sbjct: 1682 IGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETL----PI 1732
Query: 315 VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTG 374
L + T N+ G + V V + D ND+ P F Q +TG
Sbjct: 1733 YTLIIQGT----NMAGLSTNTT--VLVHLQDENDNAPVF--------------MQAEYTG 1772
Query: 375 YVDEHAS-PRIPIDD----LTMVVYDPDKGSNGTFLLSLGGPDAEA-FSVSPERAAGSAS 428
+ E AS + + D L + D DK SN + + P F++ A
Sbjct: 1773 LISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGA---- 1828
Query: 429 VQVLVRVSALVDYERQTAMAVQVVATDSVSQNF---SVAMVTIHLRDINDHRPTFPQSLY 485
+ +DYE + V D + A VT+H+ DIND P F + LY
Sbjct: 1829 ----IHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
Query: 486 --VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNG 543
L +P + V+T ++ATD D+ A+ Q+ YS+ GN + F +D +G +TV+N
Sbjct: 1885 EASLLLPTYKGV-KVIT--VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNT 1941
Query: 544 ELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDIND-NAPVVSGSYNIFVQEE--EGN 600
L ++ Y LT++A+D G + T+++I++ + + + Y+ V+E E
Sbjct: 1942 TQL----RSRYELTVRASD-GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAE 1996
Query: 601 VSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLG-PLDREAIDPALEG 659
I A N N L +++L F + +G+L G P DRE +
Sbjct: 1997 TLAVITAIGN----PINEPLFYHILNP--DRRFKISRTSGVLSTTGTPFDREQ-----QE 2045
Query: 660 RIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK-EEDPGVLVGVVKA 718
+ V V++ +P V V + VED NDN P+F Y VK + + G ++ V A
Sbjct: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTA 2105
Query: 719 WDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTV 778
D D + N + + L +F I L G + L LD + V
Sbjct: 2106 VDRD-SGRNGEVHYYLK-EHHEHFQIGPL--------GEISLKKQFELDTLNKEYLVTVV 2155
Query: 779 SAENPDPQ-GGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
+ + +P E IV + V +N P + +AE+ H V V A+ +
Sbjct: 2156 AKDGGNPAFSAEVIVPITV----MNKAMPVFE-KPFYSAEIAESIQVHSPVVHVQANSPE 2210
Query: 838 TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRAC 897
+ + + D + F++ N V IN +D+EA L +RA
Sbjct: 2211 G--------LKVFYSITDGDP----FSQFTINFNTGV-INVIAPLDFEAHPAYKLSIRAT 2257
Query: 898 DLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDD 957
D T + + + I ++D+NDN P F ++ V + E + V VRA D D
Sbjct: 2258 DSLTGAHAEVFVD-----IIVDDINDNPPVFAQQSYA-VTLSEASVIGTSVVQVRATDSD 2311
Query: 958 SGNNGVILFSI 968
S N I + +
Sbjct: 2312 SEPNRGISYQM 2322
Score = 196 bits (499), Expect = 9e-50
Identities = 197/736 (26%), Positives = 316/736 (42%), Gaps = 79/736 (10%)
Query: 13 ALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY- 68
++ V A + +P F ++ + E+LP G++ + A D D N + Y + +
Sbjct: 2796 SIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVE 2855
Query: 69 ---FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVE----DRNDNA 121
FA+ +TG + LD+E +++ + SD ++Q IV+ D ND+
Sbjct: 2856 VIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSP 2915
Query: 122 PVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAG-MVVYSIEKVIPSTGDSEHLFRI- 179
P F + +++E P G V+ + D D V Y I + GD F +
Sbjct: 2916 PRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFI-----TGGDPLGQFAVE 2970
Query: 180 -LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLD 238
+ N V K Y L + A D TF S + + V+D D
Sbjct: 2971 TIQNEWKVYVKKPLDREKRDNYLLTITATD------GTF----SSKAIVEVKVLDANDNS 3020
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVI 297
P + YS ++ ED G ++ + A D D N + Y++ S F + D G +
Sbjct: 3021 PVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGEL 3079
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
+ + LDRE+ L V AT+ G+ + SI +T+ DVND+ PEF
Sbjct: 3080 KTSTPLDREE----QAVYHLLVRATDGG----GRFCQASIVLTLE--DVNDNAPEFSADP 3129
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
F E T + D D G N L SL FS
Sbjct: 3130 YAITVFENTEPGTLLT----------------RVQATDADAGLNRKILYSLIDSADGQFS 3173
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS--VSQNFSVAMVTIHLRDIND 475
++ + ++++ +D E Q + + A D + + V + + DIND
Sbjct: 3174 IN--------ELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDIND 3225
Query: 476 HRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVS 535
+ P F Y TV E G+ V ++A D A +ITYS++ GN F +D +
Sbjct: 3226 NPPVFEYREYGATVSEDILVGTEVL-QVYAASRDIEANAEITYSIISGNEHGKFSIDSKT 3284
Query: 536 GTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVS-GSYNI 592
G V + E LD ES YYLT++ATDGG +LS T+ +++ DINDN PV S +Y
Sbjct: 3285 GAVFII--ENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTT 3342
Query: 593 FVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREA 652
+ E+ I +D G +NS + ++++ G +F++DP G ++ LDRE
Sbjct: 3343 VISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRET 3402
Query: 653 IDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL 712
I LTV SD G P V I V D+NDN P+F++ +Y+ ++E P V
Sbjct: 3403 I-----SGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKP-VG 3456
Query: 713 VGVVKAWDADQTEANN 728
V++ D+ ++N
Sbjct: 3457 FSVLQLVVTDEDSSHN 3472
Score = 173 bits (439), Expect = 9e-43
Identities = 249/959 (25%), Positives = 399/959 (41%), Gaps = 119/959 (12%)
Query: 28 ANMTSVILPE-DLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASAL 85
A++ SV+L + ++P+ +A A+ N L Y + P+ + +FA+ TG + +L
Sbjct: 1778 ASINSVVLTDRNVPLVIRA--ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSL 1835
Query: 86 DYETLYTFKVTISVSDP-----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
DYE F T+ V D + + + V V D ND PVF + S+ G
Sbjct: 1836 DYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKG 1895
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAF 199
V +V A D D + ++YSI + G+ F + G++ + + ++
Sbjct: 1896 VKVITVNATDADSSAFSQLIYSITE-----GNIGEKFSMDYKTGALTVQNTTQLRSR--- 1947
Query: 200 YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259
Y+L ++A D G + +++ I+V + + +F ++ YSA V E++ + +
Sbjct: 1948 YELTVRASD--GRFAGLTSVK--------INVKESKESHLKFTQDVYSAVVKENSTEAET 1997
Query: 260 VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGS-LDREQLLEADEEVQL 317
+ + A+ IN+P+ Y I R F I GV+ G+ DREQ E +
Sbjct: 1998 LAVITAIGNP--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQ----QEAFDV 2049
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVD 377
V TE H A + V V V D ND+ P F N LP + +V G+V
Sbjct: 2050 VVEVTEEHK----PSAVAHVVVKVIVEDQNDNAPVFVN--LPYYAVVKVDTEV---GHVI 2100
Query: 378 EHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSA 437
+ + D D G NG L E F + P G S++ +
Sbjct: 2101 RYVT-----------AVDRDSGRNGEVHYYLK-EHHEHFQIGP---LGEISLKKQFELDT 2145
Query: 438 LVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGS 497
L V VVA D + FS A V + + +N P F + Y + E S
Sbjct: 2146 L-----NKEYLVTVVAKDGGNPAFS-AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHS 2199
Query: 498 VVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLT 557
V + A P+ ++ YS+ G+ F ++ +G + V LD E+ Y L+
Sbjct: 2200 PVVH-VQANSPEGL---KVFYSITDGDPFSQFTINFNTGVINVIAP--LDFEAHPAYKLS 2253
Query: 558 LQATDG-GNLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQEEE--GNVSVTIQAHDND-E 612
++ATD + + I + DINDN PV + SY + + E G V ++A D+D E
Sbjct: 2254 IRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSE 2313
Query: 613 PGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE 672
P S +F + H F +D TGL+ L LD E + + V D G
Sbjct: 2314 PNRGISYQMFGNHSKSHDH-FHVDSSTGLISLLRTLDYEQ-----SRQHTIFVRAVDGGM 2367
Query: 673 PVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRIS 731
P L + V VT+ V D+NDN P+F Q Y + E P G V VKA+DAD ++ +
Sbjct: 2368 PTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQY 2427
Query: 732 FSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETI 791
LSG+ +F+I A G + L + +P ++L +S + +
Sbjct: 2428 SILSGNDHKHFVIDS-------ATGIITL--SNLHRHALKPFYSLNLSVSDGVFRSS--- 2475
Query: 792 VDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTS--AQLEIQLVNI 849
V V V N + P + + + +AEN H V V +D D+ + +VN
Sbjct: 2476 TQVHVTVIGGNLHSPAF-LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVND 2534
Query: 850 LCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYS 909
F + G ++ + +D E + VR +A D G +
Sbjct: 2535 FAKDR-----------FYINERGQIFTLEK--LDRETPAEKVISVRL--MAKDAGGKVAF 2579
Query: 910 NNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
++++T D NDNAP F K V I V V A D D G+N I ++I
Sbjct: 2580 CTVNVILT--DDNDNAPQF-RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI 2635
Score = 142 bits (359), Expect = 2e-33
Identities = 203/832 (24%), Positives = 334/832 (40%), Gaps = 119/832 (14%)
Query: 43 AQAFWLVAEDQDNDPLTYGMSGPNA-YFFAVTPKTGEVKLASALDYETLYTFKVTISVSD 101
A +++ + PL + ++G N F V TG + +A LD E + +T+ +D
Sbjct: 1374 AHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD 1433
Query: 102 PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVY 161
+ ++ + V D ND+ P F + + I E + + + AVD+D ++Y
Sbjct: 1434 GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIY 1491
Query: 162 SIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQC 221
+++ S+ D L + + + GSL + K D ++ +T T+
Sbjct: 1492 TLQ----SSRDPLSLKKFRLDPA---TGSLYTSEK----------LDHEAVHQHTLTVMV 1534
Query: 222 ---SLPV-----FLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGIN 273
+PV + ++V D D P F Y V E AA G+ VL V A+D DKG N
Sbjct: 1535 RDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKN 1594
Query: 274 DPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQE 332
V+YSI F I G I+ LDR E D L V AT+ +
Sbjct: 1595 AEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYD----LMVKATDKGSPPMSEI 1650
Query: 333 AKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMV 392
V I+VT+ ++ P+F + + + + +F G V H+ + V
Sbjct: 1651 TSVRIFVTI----ADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHSQ--------SSV 1697
Query: 393 VYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVV 452
VY+ G+ G +AF ++P +G+ Q + L Y + +Q
Sbjct: 1698 VYEIKDGNTG-----------DAFDINPH--SGTIITQKALDFETLPIY----TLIIQGT 1740
Query: 453 ATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVV-TDS-----IHAT 506
+S N V +HL+D ND+ P F Q+ Y + E ++ SVV TD I A
Sbjct: 1741 NMAGLSTN---TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAA 1797
Query: 507 DPDTGAWGQITYSLLPGNGADLFQVDPVSGTV-TVRNGELLDRESQAVYYLTLQATDGGN 565
D D + + Y ++ + F +D +G + TV + LD E ++++ T+Q D G
Sbjct: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS---LDYEETSIFHFTVQVHDMGT 1854
Query: 566 ----LSSSTTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPGTNNS 618
+ + +H++DIND PV + ++ + +G +T+ A D D S
Sbjct: 1855 PRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF--S 1912
Query: 619 RLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK 678
+L++++ G FS+D TG L L R LTV SD L
Sbjct: 1913 QLIYSITEGNIGEKFSMDYKTGALTVQNTTQ-------LRSRYELTVRASDGRFAGL--- 1962
Query: 679 VNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSG 738
+V I V++ ++ F Q Y+ VKE + TEA + G+
Sbjct: 1963 TSVKINVKESKESHLKFTQDVYSAVVKE---------------NSTEAETLAVITAIGNP 2007
Query: 739 ANYFMIRGLV-----LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVD 793
N + ++ G L D E Q F++ V V
Sbjct: 2008 INEPLFYHILNPDRRFKISRTSGVLS-TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVV 2066
Query: 794 VCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQV-AVVVASDVDTSAQLEI 844
V V V+D NDN P +L V + ++ G V V A D D+ E+
Sbjct: 2067 VKVIVEDQNDNAPVF--VNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEV 2116
Score = 137 bits (345), Expect = 7e-32
Identities = 269/1156 (23%), Positives = 450/1156 (38%), Gaps = 179/1156 (15%)
Query: 16 VSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM-SGPNAYFFA 71
VS + AP F A+ + E VG+ + A D+D N + Y + SG F
Sbjct: 1552 VSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFM 1611
Query: 72 VTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTA 128
+ P G +K A LD + + + +D P + + + V ++ +P F +
Sbjct: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLN 188
+S ++ET+ +GS V V A S VVY I+ +TGD+ + +G+I+
Sbjct: 1672 YSVELSETVSIGSFVGMVTA-----HSQSSVVYEIKD--GNTGDAFDINP--HSGTIITQ 1722
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA 248
+L + Y L ++ ++ G+ NT + + + D+ D P F++ Y+
Sbjct: 1723 KALDFETLP-IYTLIIQGTNMAGLSTNTTVL---------VHLQDENDNAPVFMQAEYTG 1772
Query: 249 SVAEDAAKGTSVLT-------VEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVN 300
++E A+ + VLT + A D DK N ++Y I + +F I + G I
Sbjct: 1773 LISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTV 1832
Query: 301 GSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPA 360
SLD E+ VQ+ T Y VTV V+D+ND P F A
Sbjct: 1833 LSLDYEETSIFHFTVQVHDMGTPRLFAEYAAN------VTVHVIDINDCPPVFAKPLYEA 1886
Query: 361 CTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG-GPDAEAFSVS 419
P V +T+ D D + + S+ G E FS+
Sbjct: 1887 SLLLPTYKGVKV----------------ITVNATDADSSAFSQLIYSITEGNIGEKFSM- 1929
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT 479
+ G+ +VQ ++ + + + V A+D + + V I++++ +
Sbjct: 1930 -DYKTGALTVQNTTQLRSRYE--------LTVRASDG--RFAGLTSVKINVKESKESHLK 1978
Query: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVT 539
F Q +Y V E+S + +P + Y +L N F++ SG ++
Sbjct: 1979 FTQDVYSAVVKENSTEAETLAVITAIGNPINEP---LFYHIL--NPDRRFKISRTSGVLS 2033
Query: 540 VRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL--DINDNAPV-VSGSYN--IFV 594
G DRE Q + + ++ T+ S+ + + ++ D NDNAPV V+ Y + V
Sbjct: 2034 T-TGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKV 2092
Query: 595 QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAID 654
E G+V + A D D N + + L + +F + P L + + +D
Sbjct: 2093 DTEVGHVIRYVTAVDRDSG--RNGEVHYYLKE--HHEHFQIGP----LGEISLKKQFELD 2144
Query: 655 PALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE----DPG 710
L ++TV+ D G P +V V ITV +N +P+F + Y+ + E P
Sbjct: 2145 -TLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPV 2201
Query: 711 VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYET 770
V V A+ E G + F I + G + + LD+E
Sbjct: 2202 VHV------QANSPEGLKVFYSITDGDPFSQFTIN-------FNTGVINVI--APLDFEA 2246
Query: 771 QPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAV 830
P + L++ A + G V V + V D+NDNPP S + ++E V
Sbjct: 2247 HPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSY-AVTLSEASVIGTSVVQ 2304
Query: 831 VVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLV 890
V A+D D+ I D F V ++ + I+ + +DYE
Sbjct: 2305 VRATDSDSEPNRGISYQMFGNHSKSHD-------HFHVDSSTGL-ISLLRTLDYEQSRQH 2356
Query: 891 TLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVI-IPELVLPNREVA 949
T+ VRA D G S++ + + + D+NDN P F E + + I E V
Sbjct: 2357 TIFVRA----VDGGMPTLSSDVIVTVDVTDLNDNPPLF--EQQIYEARISEHAPHGHFVT 2410
Query: 950 SVRARDDDSGNNGVILFSILRVD----FISKDGATI------------PF--------QG 985
V+A D DS + + +SIL + F+ I PF G
Sbjct: 2411 CVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDG 2470
Query: 986 VFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTT-------- 1037
VF T V G++ + LQ Y+V + A + P +E TT
Sbjct: 2471 VFRSSTQVHVTVIGGNLHS----PAFLQNEYEVEL-AENAPLHTLVMEVKTTDGDSGIYG 2525
Query: 1038 ------LNLFTVDQSYRS---------RLQFSTPKEEVGANRQAINAALTQATRTTVYIV 1082
+N F D+ Y + +L TP E+V + R A + TV ++
Sbjct: 2526 HVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI 2585
Query: 1083 DIQDIDSAARARPHSY 1098
D D+A + R Y
Sbjct: 2586 LTDDNDNAPQFRATKY 2601
Score = 114 bits (284), Expect = 8e-25
Identities = 195/856 (22%), Positives = 334/856 (39%), Gaps = 113/856 (13%)
Query: 229 ISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGW 288
+ V+D DL P F YS S+ E+ A TS+ V A D D G N Y S+ R
Sbjct: 137 VQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYY--SFKDRTDM 194
Query: 289 FDI-GADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSI-WVTVRVMDV 346
F I GVI + G LD LE + ++++ A + + +YG S+ +TV +
Sbjct: 195 FAIHPTSGVIVLTGRLD---YLET-KLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQA 250
Query: 347 NDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLL 406
N+ P + A T +P E +D + I + V D D+G+NG +
Sbjct: 251 NECAP-----VITAVTLSPSE--------LDRDPAYAI------VTVDDCDQGANGD-IA 290
Query: 407 SLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQT---AMAVQVVATDSVSQNFSV 463
SL + + S + V+ +D++ + +Q + Q SV
Sbjct: 291 SLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSV 350
Query: 464 AMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPG 523
++ + F + +Y + E + + V + A A+ + Y
Sbjct: 351 KVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVV-MVKAIP----AYSHLRYVFKST 405
Query: 524 NGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNA 583
G F ++ +G +++ E + R+ A + L + +D +ST + + +L N N
Sbjct: 406 PGKAKFSLNYNTGLISIL--EPVKRQQAAHFELEVTTSD---RKASTKVLVKVLGANSNP 460
Query: 584 PVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLR 643
P + + +E + T+ + +P + + + F++D TG +
Sbjct: 461 PEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVS 520
Query: 644 NLGPLDREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQSSYNF 702
LD E + L + SD G P +V TIT+ ++NDN P+F + +
Sbjct: 521 TSENLDYELMPRV----YTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEG 576
Query: 703 TV-KEEDPGVLVGVVKAWDAD-------QTEANNRIS-FSLSGSGANYFMIRGLVLGAGW 753
T+ ++ G + V A DAD Q EA N + FSL+ + + R L+ G G
Sbjct: 577 TIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGA 636
Query: 754 AEGY--LRLPPDVSLDYETQPVFNLTVSAENP--DPQGGET------------------- 790
+ LR+ ++ T N+TV+A + + Q ET
Sbjct: 637 KVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQ 696
Query: 791 --IVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVN 848
+ D+ + VN + P GI+V EN V + ++D+DT ++
Sbjct: 697 GEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKL---- 752
Query: 849 ILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAY 908
+ G + F + + + +D E D TL + DL G
Sbjct: 753 VYAVSGGNEDSC-----FMIDMETGM-LKILSPLDRETTDKYTLNITVYDL----GIPQK 802
Query: 909 SNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
+ L + + D NDN P FL E+ FV + E + E+ V A D D G NG + +SI
Sbjct: 803 AAWRLLHVVVVDANDNPPEFLQES-YFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI 861
Query: 969 LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSL 1028
+ FSI D G + LD LQ + + ++ARD+
Sbjct: 862 ------------VTDTDTFSI------DSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903
Query: 1029 GPFLEATTTLNLFTVD 1044
P L +T + + D
Sbjct: 904 EPQLFSTVVVKVSLED 919
Score = 77.8 bits (190), Expect = 6e-14
Identities = 138/558 (24%), Positives = 222/558 (39%), Gaps = 86/558 (15%)
Query: 310 EADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLPACTFTP 365
E + L V A E + N+ EA+ V V+V+D ND +P F Y+ SLP
Sbjct: 111 EVKDHYTLIVKALEKNTNV---EARTK--VRVQVLDTNDLRPLFSPTSYSVSLP------ 159
Query: 366 EEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAG 425
E+ + R I ++ D D G+NG F S + F++ P
Sbjct: 160 ------------ENTAIRTSIARVSAT--DADIGTNGEFYYSF-KDRTDMFAIHPTSG-- 202
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF------SVAMVTIHLRDINDHRPT 479
++ ++ +DY ++++A D + + S+A +T+H+ N+ P
Sbjct: 203 ------VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPV 256
Query: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQI-TYSLLPGNGADLFQV---DPVS 535
+ + ++VT D D GA G I + S++ G+ F+ P S
Sbjct: 257 ITAVTLSPSELDRDPAYAIVT----VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGS 312
Query: 536 GTVTVRNGELLDRESQAV-YYLTLQATDGGNLSSSTTLQ-IHLLDINDNAPVVSGSYNIF 593
V+ +D +S Y LTLQA D G ++++ IH+ A V +++
Sbjct: 313 KEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVY 372
Query: 594 VQE-EEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREA 652
E E T P ++ R +F PG FSL+ +TGL+ L P+ R+
Sbjct: 373 RAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPG--KAKFSLNYNTGLISILEPVKRQQ 430
Query: 653 IDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GV 711
L V SD V + V N N P F Q++Y E P G
Sbjct: 431 -----AAHFELEVTTSD-----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480
Query: 712 LVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQ 771
V + A D D+ E N +++S++ F I +E +LDYE
Sbjct: 481 TVMSLSAVDPDEGE-NGYVTYSIANLNHVPFAIDHFTGAVSTSE---------NLDYELM 530
Query: 772 P-VFNLTVSAENPD-PQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVA 829
P V+ L + A + P E V + + ++NDN P + + G + G Q+
Sbjct: 531 PRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGE-QIT 589
Query: 830 VVVASDVDTSAQLEIQLV 847
V A D D E+QLV
Sbjct: 590 TVSAIDAD-----ELQLV 602
Score = 53.5 bits (127), Expect = 1e-06
Identities = 53/209 (25%), Positives = 93/209 (44%), Gaps = 15/209 (7%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTA 128
F + K G + + + + YT V + ++ + ++ V V D ND P+F T+
Sbjct: 95 FLRIRTKGGNTAILNR-EVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVL 187
+S S+ E + + + V A D D+G+ G YS + D +F I +G IVL
Sbjct: 154 YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFK-------DRTDMFAIHPTSGVIVL 206
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
G L Y ++ Y++E+ A D G + + I S L++ + + P S
Sbjct: 207 TGRLDY-LETKLYEMEILAADRGMKLYGSSGI--SSMAKLTVHIEQANECAPVITAVTLS 263
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPV 276
S D +++TV+ D D+G N +
Sbjct: 264 PSEL-DRDPAYAIVTVD--DCDQGANGDI 289
Score = 52.0 bits (123), Expect = 4e-06
Identities = 65/271 (23%), Positives = 125/271 (46%), Gaps = 36/271 (13%)
Query: 485 YVLTVPEHSAT----GSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDP-VSGT-- 537
Y +TV E+SA G V ++ T P AW ++ Y ++ G+ +LF+ + + G
Sbjct: 39 YNVTVQENSAAKTYVGHPVKMGVYITHP---AW-EVRYKIVSGDSENLFKAEEYILGDFC 94
Query: 538 -VTVR----NGELLDRESQAVYYLTLQATDGG-NLSSSTTLQIHLLDINDNAPVVS-GSY 590
+ +R N +L+RE + Y L ++A + N+ + T +++ +LD ND P+ S SY
Sbjct: 95 FLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSY 154
Query: 591 NIFVQEEEG-NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLD 649
++ + E S+ + + + GTN F + F++ P +G++ G LD
Sbjct: 155 SVSLPENTAIRTSIARVSATDADIGTNGE---FYYSFKDRTDMFAIHPTSGVIVLTGRLD 211
Query: 650 REAIDPALEGRIV-LTVLVSDCGEPVLGTK-----VNVTITVEDINDNLPIFNQSSYNFT 703
LE ++ + +L +D G + G+ +T+ +E N+ P+ + + +
Sbjct: 212 ------YLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPS 265
Query: 704 VKEEDPGVLVGVVKAWDADQTEANNRISFSL 734
+ DP +V D DQ + S S+
Sbjct: 266 ELDRDPA--YAIVTVDDCDQGANGDIASLSI 294
Score = 34.7 bits (78), Expect = 0.62
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 6/86 (6%)
Query: 882 IDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPEL 941
++ E D TL+V+A + T+ + + + + D ND P F P + + V +PE
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEART-----KVRVQVLDTNDLRPLFSPTSYS-VSLPEN 161
Query: 942 VLPNREVASVRARDDDSGNNGVILFS 967
+A V A D D G NG +S
Sbjct: 162 TAIRTSIARVSATDADIGTNGEFYYS 187
Score = 33.9 bits (76), Expect = 1.1
Identities = 49/197 (24%), Positives = 84/197 (42%), Gaps = 29/197 (14%)
Query: 16 VSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYG--MSGPNAYFF 70
VS + AP F SVI+ E+ PVG LV D+D N P + ++G + F
Sbjct: 3430 VSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAF 3489
Query: 71 AVTPKTGEVKLASALDYETLYTFKVTISVSD---------PYIQVQREMLVIVEDRNDNA 121
V P+ G + +SA+ + + + + V+D YI ++ ++E+
Sbjct: 3490 EVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIR-----VIEESIYPP 3543
Query: 122 PVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEK------VIPSTGDSEH 175
+ F TS E G V+ + A D+D+ + YS++ + STG
Sbjct: 3544 AILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDT--LTYSLDPQMDNLFSVSSTGGKLI 3600
Query: 176 LFRILANGSIVLNGSLS 192
+ L G +LN S++
Sbjct: 3601 AHKKLDIGQYLLNVSVT 3617
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 237 bits (605), Expect = 5e-62
Identities = 291/1104 (26%), Positives = 474/1104 (42%), Gaps = 151/1104 (13%)
Query: 31 TSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNA-YFFAVTPKTGEVKLASALD 86
+ V + EDLPVGA + A D D N + + +S N F + +TG++K+ +D
Sbjct: 731 SDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMD 790
Query: 87 YE--TLYTFKVTI-SVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVV 143
E LY +TI + +P R + + VED NDN+PVF ++S +I E+ +G+ +
Sbjct: 791 REHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI 850
Query: 144 FSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLE 203
V A DKD+GS G V YS+ D++ F I ++ IV A Y L+
Sbjct: 851 IQVEARDKDLGSNGEVTYSV------LTDTQQ-FAINSSTGIVYVADQLDRESKANYSLK 903
Query: 204 LKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTV 263
++A D F++ +L VFL D D P F+ YS V ED GT + +
Sbjct: 904 IEARDKAESGQQLFSV-VTLKVFLD----DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWL 958
Query: 264 EAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTAT 322
E D D G+ V YS+ + G F+I A G IR++ LD E+ + L V A
Sbjct: 959 ETHDPDLGLGGQVRYSL-VNDYNGRFEIDKASGAIRLSKELDYEK----QQFYNLTVRAK 1013
Query: 323 ETHLNIYGQEAKVS--IWVTVRVMDVND--HKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378
+ G+ +S +V V V+DVN+ H P F P+ A V G V E
Sbjct: 1014 DK-----GRPVSLSSVSFVEVEVVDVNENLHTPYF-----------PDFAVV---GSVKE 1054
Query: 379 HASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSA 437
++ RI L + D D G +G S+ G FS+ E ++ +
Sbjct: 1055 NS--RIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESG--------VITAAD 1104
Query: 438 LVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATG 496
++D E + + V ATD V +S V I + D+ND+ P + +Y V E+S
Sbjct: 1105 ILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPK- 1163
Query: 497 SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
V I A DPD+ + ++TY + GN + F ++ +G +T + + LDRE QA ++L
Sbjct: 1164 DVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRK-LDREQQAEHFL 1222
Query: 557 TLQATDGGNLSSSTTL--QIHLLDINDNAPVVSGS-YNIFVQEEE----GNVSVTIQAHD 609
+ TDGG +T+ + +LD NDN P Y I + E + G A D
Sbjct: 1223 EVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282
Query: 610 NDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSD 669
DE N+ + ++++ G F +DP TG++ + + D +LT+ D
Sbjct: 1283 RDE--GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYD-------ILTIKAVD 1333
Query: 670 CGEPVLGTKVNVTITVEDINDNLPI---FNQSSYNFTVKEEDPGV-LVGVVKAWDADQTE 725
G P + + I PI F++ YNFTV E D +VGVV
Sbjct: 1334 NGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSV-----QP 1388
Query: 726 ANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDP 785
AN + F + G N+ G G + LD E + ++N++V +
Sbjct: 1389 ANTPLWFDI--VGGNFDSAFDAEKGVG------TIVIAKPLDAEQRSIYNMSVEVTDGT- 1439
Query: 786 QGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQ 845
+ V + V D NDN P + + ++E+ ++ + A+D D +L
Sbjct: 1440 --NVAVTQVFIKVLDNNDNGPEFSQPNY-DVTISEDVLPDTEILQIEATDRDEKHKLSYT 1496
Query: 846 LVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD--LVTLVVRACDLATDP 903
+ + + S+ F + + V + ++ +D+EA D ++ ++VR D
Sbjct: 1497 VHS--------SIDSISMRKFRIDPSTGV-LYTAERLDHEAQDKHILNIMVR------DQ 1541
Query: 904 GFQAYSNNGSLLITIEDVNDNAPYF---LPENKTFVIIPELVLPNREVASVRARDDDSGN 960
F N +++ +ED ND++PYF L E F E V V A D D G
Sbjct: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF----ESAALGSAVLQVTALDKDKGE 1597
Query: 961 NGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020
N ++++I G + V I T + D T G + +++
Sbjct: 1598 NAELIYTI----EAGNTGNMFKIEPVLGIITICKEP------------DMTTMGQFVLSI 1641
Query: 1021 QARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQA-------INAALTQ 1073
+ D+ S P + AT + + +V S S +F + N + +A++Q
Sbjct: 1642 KVTDQGS--PPMSATAIVRI-SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ 1698
Query: 1074 ATRTTVYIVDIQDIDSAARARPHS 1097
+ T +Y V DI+ P+S
Sbjct: 1699 S--TLIYEVKDGDINGIFTINPYS 1720
Score = 232 bits (592), Expect = 2e-60
Identities = 241/842 (28%), Positives = 372/842 (44%), Gaps = 99/842 (11%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWL-VAEDQDNDPLTYGMSGPN---AYFFAVTPKTGEV 79
P F + S + ED +G+ L + Q+ T P F + +TG +
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTI 2765
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQREMLVIVE----DRNDNAPVFQNTAFSTSINE 135
KL LD ET F ++ + P +V V V+ D NDN PVF+ +++ T I E
Sbjct: 2766 KLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIME 2825
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSI------EKVIPSTGDSEHLFRILAN-GSIVLN 188
+PVG+ + V A+D D G+ G V YS+ EKV+ + F I +N G I
Sbjct: 2826 GMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEA-------FNIDSNTGWISTL 2878
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA 248
L + F + A DLG + S +S+ V D D P F +E Y
Sbjct: 2879 KDLDHETDPTF-TFSVVASDLGEAF------SLSSTALVSVRVTDINDNAPVFAQEVYRG 2931
Query: 249 SVAEDAAKGTSVLTVEAVDGD-KGINDPVIYSISYSTRPGWFDIG---ADGVIRVNGSLD 304
+V E G V + D D +N V Y I+ G F +G ++ + V LD
Sbjct: 2932 NVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLD 2991
Query: 305 REQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFT 364
RE+ + L +TAT+ ++ +A V V V DVND+ P C
Sbjct: 2992 REE----QDIYFLNITATD---GLFVTQAMVE----VSVSDVNDNS--------PVCD-- 3030
Query: 365 PEEAQVNFTGYVDEHASPRIPIDDLTMVV--YDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
QV +T + E IP + + + V D D GSNG SL G F + PE
Sbjct: 3031 ----QVAYTALLPED----IPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPES 3082
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQ 482
++ AL+D ER ++ ATD F + + + L D+ND+ P F
Sbjct: 3083 GE--------LKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNPPVFSS 3133
Query: 483 SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRN 542
Y V E++AT +++T + A DPD G ++ YSL G +F +D SG + +
Sbjct: 3134 DHYNTCVYENTATKALLT-RVQAVDPDIGINRKVVYSLADSAGG-VFSIDSSSGIIILE- 3190
Query: 543 GELLDRESQAVYYLTLQATD---GGNLSSSTTLQIHLLDINDNAPVVS-GSYNIFVQEEE 598
+ LDRE Q+ Y ++++ATD G +LSS TT+ I +LDINDN PV Y + V E+
Sbjct: 3191 -QPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDT 3249
Query: 599 GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
+ + + N+ + + + G F ++P TG G E +D L
Sbjct: 3250 SPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG-----GISVSEVLDYELC 3304
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED-PGVLVGVVK 717
R L V D G P L V I + D+NDN P F+Q Y+ + E+ G V ++
Sbjct: 3305 KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLI 3364
Query: 718 AWDADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
A D D ++ N +I FS+ +G N F + ++ G +++ LD E ++L
Sbjct: 3365 AEDVD-SQPNGQIHFSIVNGDRDNEFTVDPVL-------GLVKVKK--KLDRERVSGYSL 3414
Query: 777 TVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836
V A + + V +++ DVNDN P A+ + + EN + +V +D
Sbjct: 3415 LVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAV-IQENKPVGTSILQLVVTDR 3473
Query: 837 DT 838
D+
Sbjct: 3474 DS 3475
Score = 230 bits (586), Expect = 8e-60
Identities = 284/1072 (26%), Positives = 445/1072 (41%), Gaps = 159/1072 (14%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD--NDPLTYGMSGPNAY--- 68
L+V+ + P F + L E +G +V+ D D N+ + + + Y
Sbjct: 2275 LLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNST 2334
Query: 69 -FFAVTPKTGEVKLASALDYETLY--TFKVTISVSDPYIQVQREMLV--IVEDRNDNAPV 123
+F + +G + A LD+E + T KV S+ + + E+LV + D NDN PV
Sbjct: 2335 DYFHIDSSSGLILTARMLDHELVQHCTLKVR-SIDSGFPSLSSEVLVHIYISDVNDNPPV 2393
Query: 124 FQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANG 183
F + + ++E P G V V A D D + YSI +G+ F + +
Sbjct: 2394 FNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI-----LSGNDRTSFLMDSKS 2448
Query: 184 SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243
++ + Y L + D G++ +T + I V+ P F +
Sbjct: 2449 GVITLSNHRKQRMEPLYSLNVSVSD--GLFTSTAQVH--------IRVLGANLYSPAFSQ 2498
Query: 244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSL 303
Y A V E+ A GT V+ V A DGD G + Y+I F I ++G + L
Sbjct: 2499 STYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERL 2558
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTF 363
DRE LE D V + V A + G V V V+D ND+ P+F
Sbjct: 2559 DRENPLEGD--VSIFVRALD------GGGRTTFCTVRVIVVDENDNAPQFMT-------- 2602
Query: 364 TPEEAQVNFTGYVDEHASPRIPIDDLTMV----VYDPDKGSNGTFLLSLGGPD----AEA 415
V+ AS R + +V DPD G+N SL A+
Sbjct: 2603 ------------VEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDIN 474
+ P+ + + + T ++ V A D + S+ V IH+
Sbjct: 2651 LEIDPDNG--------WMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPE 2702
Query: 475 DHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLP-GNGADLFQVDP 533
P+F QS Y T+ E +A GS V D++ P W P N +F ++
Sbjct: 2703 TFLPSFTQSQYSFTIAEDTAIGSTV-DTLRIL-PSQNVWFSTVNGERPENNKGGIFVIEQ 2760
Query: 534 VSGTVTVRNGELLDRESQAVYYLTLQAT---DGGNLSSSTTLQIHLLDINDNAPVV-SGS 589
+GT+ + + LDRE+ ++ + AT D ++ + + I +LD+NDN PV + S
Sbjct: 2761 ETGTIKL--DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSS 2818
Query: 590 YNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNL----LPGPYSHNFSLDPDTGLLRNL 645
Y+ + E + Q D N ++ ++L P F++D +TG + L
Sbjct: 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTL 2878
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
LD E DP +V+ SD GE L + V++ V DINDN P+F Q Y V
Sbjct: 2879 KDLDHET-DPT----FTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNV 2933
Query: 705 KEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPD 763
KE D PG +V V+ WD D ++ N ++S+ ++G GLV + W + Y++ P
Sbjct: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLV-QSEW-KVYVKRP-- 2989
Query: 764 VSLDYETQPVFNLTVSAENPDPQGGETIVD--VCVNVKDVNDNPPTLDVASLRGIRVAEN 821
LD E Q ++ L ++A + G + V V+V DVNDN P D
Sbjct: 2990 --LDREEQDIYFLNITATD-----GLFVTQAMVEVSVSDVNDNSPVCD------------ 3030
Query: 822 GSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKA 881
QVA D + I V + D+GS + +S+ +G N
Sbjct: 3031 -----QVAYTALLPEDIPSNKIILKV----SAKDADIGSNGYIRYSLYGSG----NSEFF 3077
Query: 882 IDYEACDLVTL---------VVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPEN 932
+D E+ +L TL V ATD G + +N L+ +EDVNDN P F ++
Sbjct: 3078 LDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI--LEDVNDNPPVFSSDH 3135
Query: 933 KTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTS 992
+ E + V+A D D G N +++S+ D A GVFSI +S
Sbjct: 3136 YN-TCVYENTATKALLTRVQAVDPDIGINRKVVYSL-------ADSA----GGVFSIDSS 3183
Query: 993 SEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
S G I LD Q +Y ++V+A D+ S G L + TT+ + +D
Sbjct: 3184 S------GIIILEQPLDREQQSSYNISVRATDQ-SPGQSLSSLTTVTITVLD 3228
Score = 209 bits (531), Expect = 2e-53
Identities = 269/1051 (25%), Positives = 426/1051 (40%), Gaps = 137/1051 (13%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
+P F+ + SV + EDLPVG WL D D + Y + F + +G +
Sbjct: 933 SPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAI 992
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQREMLVIVE----DRNDN--APVFQNTAFSTSI 133
+L+ LDYE + +T+ D V + VE D N+N P F + A S+
Sbjct: 993 RLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 134 NETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSY 193
E +G+ V V A D+D G G + YSI G F I ++ +
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSIRD-----GSGLGRFSIDDESGVITAADILD 1107
Query: 194 NNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAED 253
Y L + A D G + ++ V+ I V D D P Y V E+
Sbjct: 1108 RETMGSYWLTVYATDRG-----VVPLYSTIEVY--IEVEDVNDNAPLTSEPIYYPVVMEN 1160
Query: 254 AAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNG-SLDREQLLEA 311
+ K SV+ ++A D D N+ + Y I+ +F I G+I LDREQ
Sbjct: 1161 SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQ---- 1216
Query: 312 DEEVQLQVTATETHLNIYGQEAKVS-IWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
E L+VT T+ G K S IWV V+V+D ND+KP+F PE+
Sbjct: 1217 QAEHFLEVTVTDG-----GPSPKQSTIWVVVQVLDENDNKPQF-----------PEKV-- 1258
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASV 429
+ + E + +D D+G N S+ G D F + P+ S+
Sbjct: 1259 -YQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK 1317
Query: 430 QVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRP-----TFPQSL 484
Q Y+ T AV + Q S A +H+ I P TF +
Sbjct: 1318 QFTAG-----SYDILTIKAVD----NGRPQKSSTAR--LHIEWIKKPPPSPIPLTFDEPF 1366
Query: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544
Y TV E +V + +T W + ++ GN F + GT+ + +
Sbjct: 1367 YNFTVMESDRVTEIV-GVVSVQPANTPLW----FDIVGGNFDSAFDAEKGVGTIVI--AK 1419
Query: 545 LLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQEE--EGNV 601
LD E +++Y ++++ TDG N++ T + I +LD NDN P S +Y++ + E+
Sbjct: 1420 PLDAEQRSIYNMSVEVTDGTNVAV-TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE 1478
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661
+ I+A D DE S + + + F +DP TG+L LD EA D +
Sbjct: 1479 ILQIEATDRDEKH-KLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQD-----KH 1532
Query: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWD 720
+L ++V D P V + VED ND+ P F Y +V E G V V A D
Sbjct: 1533 ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALD 1592
Query: 721 ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780
D+ E I +G+ N F I ++ G + + + + Q V ++ V+
Sbjct: 1593 KDKGENAELIYTIEAGNTGNMFKIEPVL-------GIITICKEPDMTTMGQFVLSIKVTD 1645
Query: 781 ENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA 840
+ P IV + V + D N +P + + + N + +V++ S + S
Sbjct: 1646 QGSPPMSATAIVRISVTMSD-NSHPKFIH----KDYQAEVNENVDIGTSVILISAISQST 1700
Query: 841 QLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLA 900
I K G D+ G F++ V Q KA+DYE L+++A ++A
Sbjct: 1701 L-------IYEVKDG-DIN----GIFTINPYSGVITTQ-KALDYERTSSYQLIIQATNMA 1747
Query: 901 TDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVAS-------VRA 953
++N ++ I I D NDNAP FL ++ + E N V S +RA
Sbjct: 1748 ------GMASNATVNIQIVDENDNAPVFL-FSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
Query: 954 RDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQ 1013
D DS N ++++ I V+ +K T+ D G+I+ + +LD
Sbjct: 1801 TDADSNRNALLVYQI--VESTAKKFFTV--------------DSSTGAIRTIANLDHETI 1844
Query: 1014 GTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
+ V RD S E+ +N+ D
Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTD 1875
Score = 205 bits (522), Expect = 2e-52
Identities = 245/893 (27%), Positives = 367/893 (41%), Gaps = 130/893 (14%)
Query: 171 GDSEHLFRILANGSI---VLNGSLSYNNKSAFYQLELKACDL----------GGMYHNTF 217
G + RIL + ++ +NG NNK + +E + + +H F
Sbjct: 2724 GSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFH--F 2781
Query: 218 TIQCSLP---------VFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDG 268
+ ++P V + I V+D D P F Y + E GT + V A+D
Sbjct: 2782 KVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDM 2841
Query: 269 DKGINDPVIYSISYSTRPGW----FDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATE 323
D G N V YS+ ++P F+I ++ G I LD E D V A++
Sbjct: 2842 DWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHE----TDPTFTFSVVASD 2897
Query: 324 THLNIYGQEAKVS--IWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHAS 381
G+ +S V+VRV D+ND+ P F AQ + G V E
Sbjct: 2898 L-----GEAFSLSSTALVSVRVTDINDNAPVF--------------AQEVYRGNVKESDP 2938
Query: 382 PRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDY 441
P + L+ D + GG F A G + V V +D
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF------ALGLVQSEWKVYVKRPLDR 2992
Query: 442 ERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTD 501
E Q + + ATD + + AMV + + D+ND+ P Q Y +PE + ++
Sbjct: 2993 EEQDIYFLNITATDGLF--VTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIIL- 3049
Query: 502 SIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQAT 561
+ A D D G+ G I YSL G+G F +DP SG + + LLDRE VY L +AT
Sbjct: 3050 KVSAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGEL--KTLALLDRERIPVYSLMAKAT 3106
Query: 562 DGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSVTIQAHDNDEPGTNNSRL 620
DGG + + + L D+NDN PV S YN V E ++ + D N ++
Sbjct: 3107 DGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKV 3166
Query: 621 LFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE-PVLGTKV 679
+++L FS+D +G++ PLDRE + ++V +D L +
Sbjct: 3167 VYSLADSA-GGVFSIDSSSGIIILEQPLDREQ-----QSSYNISVRATDQSPGQSLSSLT 3220
Query: 680 NVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSL-SGS 737
VTITV DINDN P+F + Y TV E+ PG V V A D N I++ + SG+
Sbjct: 3221 TVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD-IGTNAEITYLIRSGN 3279
Query: 738 GANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVN 797
F I G +E LDYE F L V A++ + V +N
Sbjct: 3280 EQGKFKINPKTGGISVSE---------VLDYELCKRFYLVVEAKDGGTPALSAVATVNIN 3330
Query: 798 VKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDT--SAQLEIQLVNILCTKAG 855
+ DVNDNPP + ++E+ V +++A DVD+ + Q+ +VN
Sbjct: 3331 LTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVN------- 3382
Query: 856 VDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLL 915
G + G V + K +D E +L+V+A D G A S+ ++
Sbjct: 3383 ---GDRDNEFTVDPVLGLVKVK--KKLDRERVSGYSLLVQA----VDSGIPAMSSTATVN 3433
Query: 916 ITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFIS 975
I I DVNDN+P F P N T +I E + + D DS +NG
Sbjct: 3434 IDISDVNDNSPVFTPANYT-AVIQENKPVGTSILQLVVTDRDSFHNGP------------ 3480
Query: 976 KDGATIPFQGVFSIFTSSEADVFA----GSIQPVTSLDSTLQGTYQVTVQARD 1024
PF FSI + +E + F G ++ T Y + VQA+D
Sbjct: 3481 ------PFS--FSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 198 bits (503), Expect = 3e-50
Identities = 248/957 (25%), Positives = 405/957 (42%), Gaps = 125/957 (13%)
Query: 64 GPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPV 123
G +A +F + P++G + A L+ +K+ ++ + ++ Q + + +ED ND+ P
Sbjct: 414 GEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ--VTISIEDANDHTPE 471
Query: 124 FQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN- 182
FQ + +NE++PVG+ V +V A DKD G G + YSI S +L + N
Sbjct: 472 FQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA--------SLNLLPFVINQ 523
Query: 183 --GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQ 240
G I L + + Y+ ++A D G Y + + ++I + + D P
Sbjct: 524 FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVN------VTIRIGNVNDNSPL 577
Query: 241 FVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRV 299
F + ++ D G + V A+D D+ + V Y I G+F + D GV+++
Sbjct: 578 FEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQL 635
Query: 300 NGSLDREQLLEADEEVQLQVTATE-------THLNIYGQEAKVS---------------- 336
SL + + L++TAT+ +NI KVS
Sbjct: 636 KKSLTNSGIKNGN--FALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLA 693
Query: 337 --IWVTVRV---MDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTM 391
+ + + +++ D +FY+ + F +F V + + L +
Sbjct: 694 EKLLIKAKANGKLNLEDGFLDFYSINRQGPYF-----DKSFPSDVAVKEDLPVGANILKI 748
Query: 392 VVYDPDKGSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQ 450
YD D G NG L ++ G F++ E ++V +D E +
Sbjct: 749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQ--------LKVLMPMDREHTDLYLLN 800
Query: 451 VVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPD 509
+ D Q S ++TI++ D ND+ P F Q Y + + E S G+ + + A D D
Sbjct: 801 ITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII-QVEARDKD 859
Query: 510 TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATD----GGN 565
G+ G++TYS+L F ++ +G V V + LDRES+A Y L ++A D G
Sbjct: 860 LGSNGEVTYSVL--TDTQQFAINSSTGIVYV--ADQLDRESKANYSLKIEARDKAESGQQ 915
Query: 566 LSSSTTLQIHLLDINDNAPV-VSGSYNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLF 622
L S TL++ L D+ND +P + SY++ V E+ G V ++ HD D R
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRY-- 973
Query: 623 NLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVN-V 681
L Y+ F +D +G +R LD E + LTV D G PV + V+ V
Sbjct: 974 -SLVNDYNGRFEIDKASGAIRLSKELDYEK-----QQFYNLTVRAKDKGRPVSLSSVSFV 1027
Query: 682 TITVEDINDNL--PIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSL-SGS 737
+ V D+N+NL P F + +VKE G V V A D D + + I +S+ GS
Sbjct: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDED-SGRDGEIQYSIRDGS 1086
Query: 738 GANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDV 794
G F I G++ A D+ LD ET + LTV A + + ++V
Sbjct: 1087 GLGRFSIDDESGVITAA-----------DI-LDRETMGSYWLTVYATDRGVVPLYSTIEV 1134
Query: 795 CVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKA 854
+ V+DVNDN P + V EN + V + A D D+S+ + + T
Sbjct: 1135 YIEVEDVNDNAPLTSEPIYYPV-VMENSPKDVSVIQIQAEDPDSSSN---EKLTYRITSG 1190
Query: 855 GVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSL 914
+F++ + S+ +D E L V TD G + +
Sbjct: 1191 NPQ------NFFAINIKTGLITTTSRKLDREQQAEHFLEV----TVTDGGPSPKQSTIWV 1240
Query: 915 LITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVR--ARDDDSGNNGVILFSIL 969
++ + D NDN P F PE + +PE R R A D D G N I +SI+
Sbjct: 1241 VVQVLDENDNKPQF-PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIV 1296
Score = 195 bits (495), Expect = 3e-49
Identities = 278/1085 (25%), Positives = 461/1085 (42%), Gaps = 178/1085 (16%)
Query: 7 SCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMS 63
S + L + V A + +P F+ + SV + E +G + + A D+D N +TY +
Sbjct: 812 SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL 871
Query: 64 GPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQR-----EMLVIVEDRN 118
+ FA+ TG V +A LD E+ + + I D Q+ + V ++D N
Sbjct: 872 -TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVN 930
Query: 119 DNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFR 178
D +P F +++S + E LPVG+V+ + D D+G G V YS+ D F
Sbjct: 931 DCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSL------VNDYNGRFE 984
Query: 179 I-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD-QPD 236
I A+G+I L+ L Y K FY L ++A D G + S F+ + VVD +
Sbjct: 985 IDKASGAIRLSKELDY-EKQQFYNLTVRAKDKGR------PVSLSSVSFVEVEVVDVNEN 1037
Query: 237 LDPQFVREF-YSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD- 294
L + +F SV E++ GTSVL V A D D G + + YSI + G F I +
Sbjct: 1038 LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDES 1097
Query: 295 GVIRVNGSLDREQLLEADEEVQLQVTATETH-LNIYGQEAKVSIWVTVRVMDVNDHKPEF 353
GVI LDRE + L V AT+ + +Y +I V + V DVND+ P
Sbjct: 1098 GVITAADILDRETM----GSYWLTVYATDRGVVPLYS-----TIEVYIEVEDVNDNAP-- 1146
Query: 354 YNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG--TFLLSLGGP 411
T E + V E++ + + + + DPD SN T+ ++ G P
Sbjct: 1147 ---------LTSEPI---YYPVVMENSPKDVSV--IQIQAEDPDSSSNEKLTYRITSGNP 1192
Query: 412 DAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHL 470
F++ + ++ S +D E+Q ++V TD S S V + +
Sbjct: 1193 Q-NFFAI-------NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQV 1244
Query: 471 RDINDHRPTFPQSLYVLTVPE--HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADL 528
D ND++P FP+ +Y + +PE G + + A D D G +I+YS++ GN
Sbjct: 1245 LDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAF-AFDRDEGPNAEISYSIVDGNDDGK 1303
Query: 529 FQVDPVSGTVTVRNGELLDRESQAVYY--LTLQATDGGNLSSSTTLQIHLLDINDNAP-- 584
F +DP +G V+ R ++ A Y LT++A D G S+T ++H+ I P
Sbjct: 1304 FFIDPKTGMVSSR------KQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSP 1357
Query: 585 ----VVSGSYNIFVQEEE------GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFS 634
YN V E + G VSV +P N+ L F+++ G + F
Sbjct: 1358 IPLTFDEPFYNFTVMESDRVTEIVGVVSV--------QPA--NTPLWFDIVGGNFDSAFD 1407
Query: 635 LDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVT---ITVEDINDN 691
+ G + PLD E ++V V+D GT V VT I V D NDN
Sbjct: 1408 AEKGVGTIVIAKPLDAEQ-----RSIYNMSVEVTD------GTNVAVTQVFIKVLDNNDN 1456
Query: 692 LPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLG 750
P F+Q +Y+ T+ E+ P + ++A D D+ +++S+++ S + M +
Sbjct: 1457 GPEFSQPNYDVTISEDVLPDTEILQIEATDRDE---KHKLSYTVHSSIDSISMRK----- 1508
Query: 751 AGWAEGYLRLPPDVS-------LDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVND 803
R+ P LD+E Q L + + + + V VNV+D ND
Sbjct: 1509 -------FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1561
Query: 804 NPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCW 863
+ P L V E+ + V V A D D E+ I +AG + G++
Sbjct: 1562 HSPYF-TNPLYEASVFESAALGSAVLQVTALDKDKGENAEL----IYTIEAG-NTGNM-- 1613
Query: 864 GWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVND 923
F + + I K D L ++ TD G S + I++ ++
Sbjct: 1614 --FKIEPVLGI-ITICKEPDMTTMGQFVLSIK----VTDQGSPPMSATAIVRISVTMSDN 1666
Query: 924 NAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFI--SKDGATI 981
+ P F+ +++ + + D G + +++ +I + I KDG
Sbjct: 1667 SHPKFI---------------HKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDG--- 1708
Query: 982 PFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLF 1041
G+F+I + ++G I +LD +YQ+ +QA + + + T+N+
Sbjct: 1709 DINGIFTI------NPYSGVITTQKALDYERTSSYQLIIQATNMAGMA----SNATVNIQ 1758
Query: 1042 TVDQS 1046
VD++
Sbjct: 1759 IVDEN 1763
Score = 186 bits (472), Expect = 1e-46
Identities = 263/1056 (24%), Positives = 431/1056 (40%), Gaps = 162/1056 (15%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDND-PLTY----GMSGPNAYFFAVTPKTGE 78
P+F V + ED+ + + A D+D L+Y + + F + P TG
Sbjct: 1458 PEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGV 1517
Query: 79 VKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
+ A LD+E + I V D PY + ++V VED ND++P F N + S+ E
Sbjct: 1518 LYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFE 1577
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNN 195
+ +GS V V A+DKD G ++Y+IE G++ ++F+I I+
Sbjct: 1578 SAALGSAVLQVTALDKDKGENAELIYTIE-----AGNTGNMFKIEPVLGIITICKEPDMT 1632
Query: 196 KSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAA 255
+ L +K D G + S + ISV + P+F+ + Y A V E+
Sbjct: 1633 TMGQFVLSIKVTDQG-------SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD 1685
Query: 256 KGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEE 314
GTSV+ + A+ +IY + G F I GVI +LD E+
Sbjct: 1686 IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYER----TSS 1736
Query: 315 VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLPACTFTPEEAQV 370
QL + AT N+ G + + V ++++D ND+ P F Y+ SL E A +
Sbjct: 1737 YQLIIQAT----NMAGMASNAT--VNIQIVDENDNAPVFLFSQYSGSL------SEAAPI 1784
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA---FSVSPERAAGSA 427
N S +D+ +V+ D SN LL ++ A F+V A
Sbjct: 1785 N---------SIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGA--- 1832
Query: 428 SVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF---SVAMVTIHLRDINDHRPTFPQSL 484
+R A +D+E V DS S S V I + D+ND+ P F Q++
Sbjct: 1833 -----IRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
Query: 485 Y--VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRN 542
+ +L +P + V + ATDPD+ ++TYSL+ G+ D F +D SG +T++N
Sbjct: 1888 FETILLLPTYV---GVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN 1943
Query: 543 GELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVS 602
L S+ Y L ++ +DG S+S + ++ Y+ + E N +
Sbjct: 1944 NNL----SKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSI--SENNTN 1997
Query: 603 VTIQAHDNDEPGTNNSRLLFNLL-PGPYSHNFSLDPDTGLLRNLG-PLDREAIDPALEGR 660
+T A N N L +++L PG + F + +G+++ G P DRE +
Sbjct: 1998 ITKVAIVNAVGNRLNEPLKYSILNPG---NKFKIKSTSGVIQTTGVPFDREE-----QEL 2049
Query: 661 IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK-EEDPGVLVGVVKAW 719
L V S + + +V V + +EDINDN P+F Y V+ + +PG L+ V A
Sbjct: 2050 YELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAI 2109
Query: 720 DADQTEANNRISFSLSGSGANYFM---IRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
D D+ N +++ L ++ + ++L + + V++ + +L
Sbjct: 2110 DKDK-GPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSL 2168
Query: 777 TVSAENP-------DPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVA 829
+ S E P P + VN +D+ N P L + + S GQ
Sbjct: 2169 STSVELPITIVNKAMPVFDKPFYTASVN-EDIRMNTPILSINAT---------SPEGQGI 2218
Query: 830 VVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDL 889
+ + D D Q I D G L +DYE
Sbjct: 2219 IYIIIDGDPFKQFNIDF----------DTGVL---------------KVVSPLDYEVTSA 2253
Query: 890 VTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTF-VIIPELVLPNREV 948
L +RA D T + ++ + + DVNDN P F + T+ + E L V
Sbjct: 2254 YKLTIRASDALTGARAEV-----TVDLLVNDVNDNPPIF--DQPTYNTTLSEASLIGTPV 2306
Query: 949 ASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSL 1008
V + D DS NN ++ + I++ + S D F I +SS G I L
Sbjct: 2307 LQVVSIDADSENNKMVHYQIVQDTYNSTD--------YFHIDSSS------GLILTARML 2352
Query: 1009 DSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
D L T++ R S P L + ++++ D
Sbjct: 2353 DHEL--VQHCTLKVRSIDSGFPSLSSEVLVHIYISD 2386
Score = 170 bits (431), Expect = 7e-42
Identities = 267/1094 (24%), Positives = 429/1094 (39%), Gaps = 212/1094 (19%)
Query: 21 NVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFF-------AVT 73
++ P F SV + E P+ + A D D G +G Y+F +V
Sbjct: 153 DLRPLFSPTTYSVTIAESTPLRTSVAQVTATDAD-----IGSNGEFYYYFKNKVDLFSVH 207
Query: 74 PKTGEVKLASALDYETLYTFKVTISVSDPYIQVQ--------REMLVIVEDRNDNAP--- 122
P +G + L+ L+Y+ + + I D +++ ++ V +E N++AP
Sbjct: 208 PTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIH 267
Query: 123 VFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN 182
V + FS T V V D D G+ G IE V GD F +
Sbjct: 268 VVTHVPFSLEKEPTYAV------VTVDDLDDGANG----EIESVSIVAGDPLDQFFLAKE 317
Query: 183 GS------IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPD 236
G I + + + Y L L+A D G +CS + I +
Sbjct: 318 GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQ------KCSALKAVYIGNPTRDT 371
Query: 237 LDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPG----WFDIG 292
+ +F +E Y S++E + G V V+ P + Y PG +F I
Sbjct: 372 VPIRFEKEVYDVSISEFSPPGVVVAIVKL--------SPEPIDVEYKLSPGEDAVYFKIN 423
Query: 293 ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPE 352
+ V R E +L+VT +E + VT+ + D NDH PE
Sbjct: 424 PRSGLIVTA---RPLNTVKKEVYKLEVT---------NKEGDLKAQVTISIEDANDHTPE 471
Query: 353 FYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPD 412
F Q + YV+E S + LT+ D DKG NG S+ +
Sbjct: 472 FQ--------------QPLYDAYVNE--SVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
Query: 413 AEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVV-ATD--SVSQNFSVAMVTIH 469
F ++ S + ++ D+E + +V A+D S ++ S VTI
Sbjct: 516 LLPFVINQFTGVISTTEEL--------DFESSPEIYRFIVRASDWGSPYRHESEVNVTIR 567
Query: 470 LRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLF 529
+ ++ND+ P F + + G +T ++ A D D + Y ++ GN F
Sbjct: 568 IGNVNDNSPLFEKVACQGVISYDFPVGGHIT-AVSAIDIDE--LELVKYKIISGNELGFF 624
Query: 530 QVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL------------ 577
++P SG + ++ + L + ATDG NL+ ++ I +L
Sbjct: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCR 684
Query: 578 --------------------------------DINDNAPVVSGSY--NIFVQEE--EGNV 601
IN P S+ ++ V+E+ G
Sbjct: 685 ETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGAN 744
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661
+ I+A+D D N ++LF + G F++D +TG L+ L P+DRE D L
Sbjct: 745 ILKIKAYDAD--SGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL---- 798
Query: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWD 720
L + + D G P + +TI VED NDN P+F Q SY+ + E G + V+A D
Sbjct: 799 -LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
Query: 721 ADQTEANNRISFSLSGSGANYFMIR---GLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT 777
D +N +++S+ + F I G+V A LD E++ ++L
Sbjct: 858 KD-LGSNGEVTYSVL-TDTQQFAINSSTGIVYVAD------------QLDRESKANYSLK 903
Query: 778 VSAENPDPQGGE--TIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASD 835
+ A + G + ++V + V + DVND P + S ++V E+ +A + D
Sbjct: 904 IEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF-IPSSYSVKVLEDLPVGTVIAWLETHD 962
Query: 836 VD--TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLV 893
D Q+ LVN + +D A+G++ + SK +DYE L
Sbjct: 963 PDLGLGGQVRYSLVNDYNGRFEID-----------KASGAIRL--SKELDYEKQQFYNLT 1009
Query: 894 VRACDLATDPGFQAYSNNGSLLITIEDVNDN--APYFLPENKTFVIIPELVLPNREVASV 951
VRA D + S + + + DVN+N PYF P+ + E V V
Sbjct: 1010 VRAKDKGRPVSLSSVS---FVEVEVVDVNENLHTPYF-PDFAVVGSVKENSRIGTSVLQV 1065
Query: 952 RARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDST 1011
ARD+DSG +G I +SI +DG+ + G FSI D +G I LD
Sbjct: 1066 TARDEDSGRDGEIQYSI-------RDGSGL---GRFSI------DDESGVITAADILDRE 1109
Query: 1012 LQGTYQVTVQARDR 1025
G+Y +TV A DR
Sbjct: 1110 TMGSYWLTVYATDR 1123
Score = 147 bits (370), Expect = 9e-35
Identities = 198/817 (24%), Positives = 325/817 (39%), Gaps = 125/817 (15%)
Query: 34 ILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY-FFAVTPKTGEVKLASA-LDYE 88
++ E+ P + AED D N+ LTY ++ N FFA+ KTG + S LD E
Sbjct: 1156 VVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE 1215
Query: 89 TLYTFKVTISVSDPYIQVQRE---MLVIVEDRNDNAPVFQNTAFSTSINET--LPVGSVV 143
+ ++V+D ++ ++V V D NDN P F + + E G +
Sbjct: 1216 QQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPI 1275
Query: 144 FSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLE 203
+ A D+D G + YSI G+ + F I +V S ++ L
Sbjct: 1276 YRAFAFDRDEGPNAEISYSIVD-----GNDDGKFFIDPKTGMV--SSRKQFTAGSYDILT 1328
Query: 204 LKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDP---QFVREFYSASVAEDAAKGTSV 260
+KA D G Q S L I + +P P F FY+ +V E
Sbjct: 1329 IKAVDNGRP-------QKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMES------- 1374
Query: 261 LTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVT 320
D+ + S+ + P WFDI V G+ D +A++ V V
Sbjct: 1375 --------DRVTEIVGVVSVQPANTPLWFDI-------VGGNFD--SAFDAEKGVGTIVI 1417
Query: 321 ATETHL---NIYGQEAKVS-------IWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
A +IY +V+ V ++V+D ND+ PEF +Q
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEF--------------SQP 1463
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQ 430
N+ + E P I + D + T S+ F + P S
Sbjct: 1464 NYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDP-------STG 1516
Query: 431 VLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTV 489
VL L D+E Q + ++ D ++A V +++ D NDH P F LY +V
Sbjct: 1517 VLYTAERL-DHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575
Query: 490 PEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRE 549
E +A GS V + A D D G ++ Y++ GN ++F+++PV G +T+ D
Sbjct: 1576 FESAALGSAVLQ-VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEP--DMT 1632
Query: 550 SQAVYYLTLQATDGGNLSSSTTLQIHL---LDINDNAPVVSGSYNIFVQE--EEGNVSVT 604
+ + L+++ TD G+ S T + + + N + + Y V E + G +
Sbjct: 1633 TMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL 1692
Query: 605 IQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLT 664
I A + S L++ + G + F+++P +G++ LD E
Sbjct: 1693 ISA-------ISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSS-------YQ 1738
Query: 665 VLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVG--------VV 716
+++ + + V I + D NDN P+F S Y+ ++ E P + V+
Sbjct: 1739 LIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVI 1798
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
+A DAD N + + + S A F GA + +LD+ET F+
Sbjct: 1799 RATDADSNR-NALLVYQIVESTAKKFFTVDSSTGA--------IRTIANLDHETIAHFHF 1849
Query: 777 TVSA-ENPDPQ-GGETIVDVCVNVKDVNDNPPTLDVA 811
V ++ PQ E+ V+V + V DVNDNPP A
Sbjct: 1850 HVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQA 1886
Score = 135 bits (341), Expect = 2e-31
Identities = 230/995 (23%), Positives = 404/995 (40%), Gaps = 164/995 (16%)
Query: 91 YTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVD 150
Y V SV ++ ++ + V D ND P+F T +S +I E+ P+ + V V A D
Sbjct: 125 YLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATD 184
Query: 151 KDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDL 209
D+GS G Y + + LF + +G I L+G L+Y+ K+ Y LE+ A D
Sbjct: 185 ADIGSNGEFYYYFKNKV-------DLFSVHPTSGVISLSGRLNYDEKNR-YDLEILAVDR 236
Query: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
G + + + +++ I +++ + + + +V+TV+ +D
Sbjct: 237 GMKLYGNNGVSSTAKLYVHIERINE---HAPTIHVVTHVPFSLEKEPTYAVVTVDDLD-- 291
Query: 270 KGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIY 329
DG NG ++ ++ D Q + LN Y
Sbjct: 292 ------------------------DG---ANGEIESVSIVAGDPLDQFFLAKEGKWLNEY 324
Query: 330 G-QEAKVSIWVTVRVMDVNDHKPEFYNCSLPA-CTFTPEEAQVNFTGYVDEHASPRIPID 387
+E K W + P YN +L A +P++ Y+ +PI
Sbjct: 325 KIKERKQIDW---------ESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIR 375
Query: 388 ------DLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDY 441
D+++ + P LS D E + +SP A ++ R +V
Sbjct: 376 FEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE-YKLSPGEDA--VYFKINPRSGLIVTA 432
Query: 442 ERQTAMAVQVVATDSVSQNFSV-AMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVT 500
+ +V + ++ + A VTI + D NDH P F Q LY V E G+ V
Sbjct: 433 RPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVL 492
Query: 501 DSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQA 560
++ A+D D G G ITYS+ N F ++ +G ++ EL S +Y ++A
Sbjct: 493 -TVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTE-ELDFESSPEIYRFIVRA 549
Query: 561 TDGGN---LSSSTTLQIHLLDINDNAPV---VSGSYNIFVQEEEGNVSVTIQAHDNDEPG 614
+D G+ S + I + ++NDN+P+ V+ I G + A D DE
Sbjct: 550 SDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE-- 607
Query: 615 TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI------------------DPA 656
+ + ++ G F L+PD+G+L+ L I DP
Sbjct: 608 --LELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPM 665
Query: 657 LEGRIVLTVLVS----DCGEP----------VLGTKVNVTITVED-------INDNLPIF 695
VL VS C E ++ K N + +ED IN P F
Sbjct: 666 SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYF 725
Query: 696 NQS-SYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLS-GSGANYFMIRGLVLGAG 752
++S + VKE+ P G + +KA+DAD + N ++ F++S G+ + F I
Sbjct: 726 DKSFPSDVAVKEDLPVGANILKIKAYDAD-SGFNGKVLFTISDGNTDSCFNI-------D 777
Query: 753 WAEGYLRLPPDVSLDYETQPVFNLTV-SAENPDPQGGETIVDVCVNVKDVNDNPPTLDVA 811
G L++ + ++ + N+T+ NP + +NV+D NDN P +
Sbjct: 778 METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT---INVEDANDNSPVF-IQ 833
Query: 812 SLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV-AA 870
+ + E+ ++ V A D D + E+ + T+ F++ ++
Sbjct: 834 DSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ-----------FAINSS 882
Query: 871 NGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLP 930
G VY+ + +D E+ +L + A D A + G Q +S +L + ++DVND +P F+P
Sbjct: 883 TGIVYV--ADQLDRESKANYSLKIEARDKA-ESGQQLFS-VVTLKVFLDDVNDCSPAFIP 938
Query: 931 ENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIF 990
+ + ++ +L + +A + D D G G + +S++ + G F
Sbjct: 939 SSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-----------DYNGRF--- 983
Query: 991 TSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR 1025
E D +G+I+ LD Q Y +TV+A+D+
Sbjct: 984 ---EIDKASGAIRLSKELDYEKQQFYNLTVRAKDK 1015
Score = 131 bits (330), Expect = 4e-30
Identities = 206/872 (23%), Positives = 346/872 (39%), Gaps = 141/872 (16%)
Query: 227 LSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRP 286
++I V+D DL P F YS ++AE TSV V A D D G N Y + +
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYY--YFKNKV 201
Query: 287 GWFDI-GADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVS-IWVTVRVM 344
F + GVI ++G L+ ++ D L++ A + + +YG S + V +
Sbjct: 202 DLFSVHPTSGVISLSGRLNYDEKNRYD----LEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
Query: 345 DVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTF 404
+N+H P ++ T P + T V + +DDL D G+NG
Sbjct: 258 RINEHAP-----TIHVVTHVPFSLEKEPTYAV-------VTVDDL-------DDGANGEI 298
Query: 405 --LLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYER-QTAMAVQVVATDSVSQNF 461
+ + G + F ++ E G + ++ +D+E + + A D S
Sbjct: 299 ESVSIVAGDPLDQFFLAKE---GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
Query: 462 SVAMVTIHLRDINDHRPTFP----QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQIT 517
A+ +++ N R T P + +Y +++ E S G VV + +P +
Sbjct: 356 CSALKAVYIG--NPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPI-----DVE 408
Query: 518 YSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL 577
Y L PG A F+++P SG + L+ + VY L + + G+L + T+ I
Sbjct: 409 YKLSPGEDAVYFKINPRSGLIV--TARPLNTVKKEVYKLEVTNKE-GDLKAQVTISIE-- 463
Query: 578 DINDNAPVVSGS-YNIFVQEE--EGNVSVTIQAHDNDEPGTNN----SRLLFNLLPGPYS 630
D ND+ P Y+ +V E G +T+ A D D+ G N S NLLP
Sbjct: 464 DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDK-GENGYITYSIASLNLLP---- 518
Query: 631 HNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL-GTKVNVTITVEDIN 689
F ++ TG++ LD E+ P + I V SD G P ++VNVTI + ++N
Sbjct: 519 --FVINQFTGVISTTEELDFES-SPEIYRFI---VRASDWGSPYRHESEVNVTIRIGNVN 572
Query: 690 DNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTE-------ANNRISFSLSGSGANY 741
DN P+F + + + + P G + V A D D+ E + N + F +
Sbjct: 573 DNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGV 632
Query: 742 FMIRGLVLGAGWAEGYLRL------------PPDVSLDYETQPVFNLTVSAE-------- 781
++ + +G G L P +++ V + + S
Sbjct: 633 LQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKL 692
Query: 782 ------NPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASD 835
G + D ++ +N P D + + V E+ + + A D
Sbjct: 693 AEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYD 752
Query: 836 VDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAI---DYEACDLVTL 892
D+ G + ++ G N + Q K + D E DL L
Sbjct: 753 ADSGFN-------------GKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLL 799
Query: 893 VVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVR 952
+ DL G S+ L I +ED NDN+P F+ ++ + I+ + E+ V
Sbjct: 800 NITIYDL----GNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGI-GTEIIQVE 854
Query: 953 ARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTL 1012
ARD D G+NG + +S+L T Q F+I +S+ G + LD
Sbjct: 855 ARDKDLGSNGEVTYSVL----------TDTQQ--FAINSST------GIVYVADQLDRES 896
Query: 1013 QGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
+ Y + ++ARD+ G L + TL +F D
Sbjct: 897 KANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Score = 125 bits (315), Expect = 2e-28
Identities = 204/851 (23%), Positives = 355/851 (41%), Gaps = 94/851 (11%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDND---PLTYGMSGPNAYFFAVTPKTGEVK 80
P F + IL VG + + A D D++ LTY + + F + +G +
Sbjct: 1881 PVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLT 1940
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
+ + + Y + + VSD + ++V++ D+ F + +STSI+E
Sbjct: 1941 IKNNNLSKDHYM--LIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSA-F 199
+ V V AV + + YSI + + F+I + ++ + ++ +
Sbjct: 1999 TKVAIVNAVGNRLNEP--LKYSIL-------NPGNKFKIKSTSGVIQTTGVPFDREEQEL 2049
Query: 200 YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259
Y+L ++A + H V + +++ D D P FV Y A+V DA GT
Sbjct: 2050 YELVVEASR--ELDHLRVA-----RVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTL 2102
Query: 260 VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEAD-EEVQLQ 318
+ V A+D DKG N V Y + G F+I + +G++ ++ +D ++
Sbjct: 2103 IYQVTAIDKDKGPNGEVTYVLQDDY--GHFEINPN-----SGNVILKEAFNSDLSNIEYG 2155
Query: 319 VTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378
VT G + +S V + + VN P F + +T V+E
Sbjct: 2156 VTILAKD----GGKPSLSTSVELPITIVNKAMPVF--------------DKPFYTASVNE 2197
Query: 379 HASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSAL 438
PI L++ P+ G + + G + F++ + +++V +
Sbjct: 2198 DIRMNTPI--LSINATSPE--GQGIIYIIIDGDPFKQFNIDFDTG--------VLKVVSP 2245
Query: 439 VDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSV 498
+DYE +A + + A+D+++ + V + + D+ND+ P F Q Y T+ E S G+
Sbjct: 2246 LDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTP 2305
Query: 499 VTDSIHATDPDTGAWGQITYSLLPG--NGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
V + + D D+ + Y ++ N D F +D SG + +LD E L
Sbjct: 2306 VLQVV-SIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLIL--TARMLDHELVQHCTL 2362
Query: 557 TLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQE--EEGNVSVTIQAHDND 611
+++ D G +LSS + I++ D+NDN PV + Y +V E G+ +QA D D
Sbjct: 2363 KVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDAD 2422
Query: 612 EPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCG 671
++ RL +++L G +F +D +G++ L ++ ++P L V VSD
Sbjct: 2423 --SSDFDRLEYSILSGNDRTSFLMDSKSGVI-TLSNHRKQRMEPLYS----LNVSVSD-- 2473
Query: 672 EPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRI 730
+ + V I V N P F+QS+Y V+E G V V+A D D +I
Sbjct: 2474 -GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD-PGTYGQI 2531
Query: 731 SFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGET 790
S+++ ++ R L+ G ++ LD E ++++ D G T
Sbjct: 2532 SYAIIN---DFAKDRFLIDSNG------QVITTERLDRENPLEGDVSIFVRALDGGGRTT 2582
Query: 791 IVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNIL 850
V V V D NDN P R A+ G H V V A D D A I L
Sbjct: 2583 FCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGH-LVTQVQAIDPDDGANSRI--TYSL 2639
Query: 851 CTKAGVDVGSL 861
++A V V L
Sbjct: 2640 YSEASVSVADL 2650
Score = 112 bits (279), Expect = 3e-24
Identities = 180/837 (21%), Positives = 329/837 (39%), Gaps = 142/837 (16%)
Query: 327 NIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPI 386
++ G++ + V ++V+D+ND +P F + ++ + E R +
Sbjct: 132 SVRGEDLEAWTKVNIQVLDMNDLRPLF--------------SPTTYSVTIAESTPLRTSV 177
Query: 387 DDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTA 446
+T D D GSNG F + FSV P ++ +S ++Y+ +
Sbjct: 178 AQVTAT--DADIGSNGEFYYYFKNK-VDLFSVHPTSG--------VISLSGRLNYDEKNR 226
Query: 447 MAVQVVATDSVSQNF------SVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVT 500
++++A D + + S A + +H+ IN+H PT +V E T +VVT
Sbjct: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVT 286
Query: 501 DSIHATDPDTGAWGQI-TYSLLPGNGADLFQVDPVSGTVT---VRNGELLDRESQAV-YY 555
D D GA G+I + S++ G+ D F + + ++ + +D ES Y
Sbjct: 287 ----VDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYN 342
Query: 556 LTLQATDGGNLSSSTTLQIHLLD--INDNAPV--VSGSYNIFVQEEEGNVSVTIQAHDND 611
LTLQA D G+ + L+ + D P+ Y++ + E V +
Sbjct: 343 LTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSP 402
Query: 612 EPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCG 671
EP + + L PG + F ++P +GL+ PL+ ++ + + + G
Sbjct: 403 EP----IDVEYKLSPGEDAVYFKINPRSGLIVTARPLN------TVKKEVYKLEVTNKEG 452
Query: 672 EPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRI 730
+ K VTI++ED ND+ P F Q Y+ V E P G V V A D D+ E N I
Sbjct: 453 D----LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGE-NGYI 507
Query: 731 SFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQP-VFNLTVSAEN-PDPQGG 788
++S++ F+I E LD+E+ P ++ V A + P
Sbjct: 508 TYSIASLNLLPFVINQFTGVISTTE---------ELDFESSPEIYRFIVRASDWGSPYRH 558
Query: 789 ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVN 848
E+ V+V + + +VNDN P + + +G+ ++ + G + V A D+D ++ ++++
Sbjct: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGV-ISYDFPVGGHITAVSAIDIDELELVKYKIIS 617
Query: 849 --------------ILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLV- 893
+L K + + G F++ + N + + L V
Sbjct: 618 GNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVS 677
Query: 894 --------VRACDLATDPGFQAYSNNGSL-----LITIEDVNDNAPYFLPENKTFVIIPE 940
R + NG L + +N PYF + V + E
Sbjct: 678 SKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKE 737
Query: 941 LVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAG 1000
+ + ++A D DSG NG +LF+I DG T F+I D+ G
Sbjct: 738 DLPVGANILKIKAYDADSGFNGKVLFTI-------SDGNT---DSCFNI------DMETG 781
Query: 1001 SIQPVTSLDSTLQGTY------------------QVTVQARDRPSLGP-FLEATTTLNLF 1041
++ + +D Y +T+ D P F++ + ++N+
Sbjct: 782 QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNIL 841
Query: 1042 TVDQSYRSRLQFSTPKEEVGANRQAINAALT-------QATRTTVYIVDIQDIDSAA 1091
+Q +++G+N + + LT ++ VY+ D D +S A
Sbjct: 842 ESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKA 898
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 232 bits (592), Expect = 2e-60
Identities = 239/837 (28%), Positives = 371/837 (44%), Gaps = 103/837 (12%)
Query: 35 LPEDLPVGAQAFWLVAEDQDNDP-------LTYGMSGPNAYFFAVTPKTGEVKLASALDY 87
L E+L VG + + A D D P L G G + F + P++G ++ +D
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
Query: 88 ETLYTFKVTISVSDPYIQ-----VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSV 142
E + ++++T+ SD + + VED NDNAP F + + E + G+
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 143 VFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN-GSIVLNGSLSYNNKSAFYQ 201
V V A D+D GS +V YSI +G++ F + A G++ + L Y Y
Sbjct: 418 VLRVTASDRDKGSNAVVHYSI-----MSGNARGQFYLDAQTGALDVVSPLDYETTKE-YT 471
Query: 202 LELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVL 261
L ++A D G + ++ +++ V+D D P FV + A+V E G VL
Sbjct: 472 LRVRAQDGGRPPLS------NVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
Query: 262 TVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQL------LEADEE 314
V+A+D D G N + Y ++ F I G I V LDRE++ +EA +
Sbjct: 526 HVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 315 VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTG 374
+TA+ + V+V V+DVND+ P F Q +T
Sbjct: 586 GTPALTASAS--------------VSVTVLDVNDNNPTF--------------TQPEYTV 617
Query: 375 YVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVR 434
++E A+ + +T+ D D S T+ ++ G FS++ + G LV
Sbjct: 618 RLNEDAAVGTSV--VTVSAVDRDAHSVITYQITSGNT-RNRFSITSQSGGG------LVS 668
Query: 435 VSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSA 494
++ +DY+ + + V A+D Q+ A + +++ D N HRP F S Y + V E
Sbjct: 669 LALPLDYKLERQYVLAVTASDGTRQD--TAQIVVNVTDANTHRPVFQSSHYTVNVNEDRP 726
Query: 495 TGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVY 554
G+ V I ATD DTG +ITY + + F++D +G VT + LD E Q Y
Sbjct: 727 AGTTVV-LISATDEDTGENARITYFM--EDSIPQFRIDADTGAVTTQAE--LDYEDQVSY 781
Query: 555 YLTLQATDGG--NLSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEEGNVSVTIQAHDND 611
L + A D G S +T L+I + D+NDNAP + SY V E+ + +Q D
Sbjct: 782 TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 612 EPGTNNSRLLFNLLPGPYSH-NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDC 670
N R+ + G +F ++ +G++R L LDRE + + VL D
Sbjct: 842 RDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENV-----AQYVLRAYAVDK 896
Query: 671 GEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNR 729
G P T + VT+TV D+NDN P+F Q ++ V+E P G+ V V A D D+ N +
Sbjct: 897 GMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG-TNAQ 955
Query: 730 ISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGG 788
I + + G+ F L + +G L V LDYE +P + L + A +
Sbjct: 956 IMYQIVEGNIPEVFQ---LDIFSG------ELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
Query: 789 ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQH---GQVAVVVASDVDTSAQL 842
T V V + D NDNPP L + N S G + V A D D S L
Sbjct: 1007 AT---VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSL 1060
Score = 221 bits (562), Expect = 5e-57
Identities = 240/847 (28%), Positives = 350/847 (41%), Gaps = 81/847 (9%)
Query: 21 NVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMSG----PNAYFFAVT 73
N AP+F +PE+ P G L A D D L Y M + FF++
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 74 PKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
P TG V A LD ET T ++ D P + ++V D ND+ PVF+ +
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGS 190
S+ E L VG V +V A D D ++Y + + S G +F I ++
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLE--GSGGSPSEVFEIDPRSGVIRTRG 353
Query: 191 LSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASV 250
+ YQL ++A D G + + VFLS+ D D PQF + Y V
Sbjct: 354 PVDREEVESYQLTVEASDQG---RDPGPRSTTAAVFLSVE--DDNDNAPQFSEKRYVVQV 408
Query: 251 AEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLL 309
ED G VL V A D DKG N V YSI G F + A G + V LD E
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
Query: 310 EADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQ 369
E V+ Q N+ G VTV+V+D+ND+ P F + TP +A
Sbjct: 469 EYTLRVRAQDGGRPPLSNVSG-------LVTVQVLDINDNAPIFVS--------TPFQAT 513
Query: 370 VNFTGYVDEHASPRIPIDDLTMVV--YDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSA 427
V +P+ L + V D D G N L G + F + G
Sbjct: 514 V----------LESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD-FPFTINNGTG-- 560
Query: 428 SVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV-AMVTIHLRDINDHRPTFPQSLYV 486
+ V+A +D E + V A D + + A V++ + D+ND+ PTF Q Y
Sbjct: 561 ----WISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYT 616
Query: 487 LTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELL 546
+ + E +A G+ V ++ A D D A ITY + GN + F + SG V L
Sbjct: 617 VRLNEDAAVGTSVV-TVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPL 673
Query: 547 DRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSVTI 605
D + + Y L + A+D G + + +++ D N + PV S Y + V E+ + +
Sbjct: 674 DYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
Query: 606 QAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTV 665
DE N+R+ + + F +D DTG + LD E + L +
Sbjct: 733 LISATDEDTGENARITYFMEDS--IPQFRIDADTGAVTTQAELDYED-----QVSYTLAI 785
Query: 666 LVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQT 724
D G P + I V D+NDN P F + SY +V E+ P V + A D D +
Sbjct: 786 TARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-S 844
Query: 725 EANNRISFSLSG--SGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAEN 782
N R+ ++ G G F++ G +R LD E + L A +
Sbjct: 845 GLNGRVFYTFQGGDDGDGDFIVES-------TSGIVRTLR--RLDRENVAQYVLRAYAVD 895
Query: 783 PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD--TSA 840
T ++V V V DVNDNPP + + V EN VA V A+D D T+A
Sbjct: 896 KGMPPARTPMEVTVTVLDVNDNPPVFEQDEF-DVFVEENSPIGLAVARVTATDPDEGTNA 954
Query: 841 QLEIQLV 847
Q+ Q+V
Sbjct: 955 QIMYQIV 961
Score = 217 bits (552), Expect = 7e-56
Identities = 259/933 (27%), Positives = 409/933 (43%), Gaps = 126/933 (13%)
Query: 117 RNDN-APVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
RN N AP FQ ++ ++ E P G+ V S+ A+D D G AG + Y+++ + S S
Sbjct: 173 RNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSR--SNQ 230
Query: 176 LFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ 234
F + G++ L KS + + A D G + L+I V D
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKST-HVFRVTAQDHGMPRRSALAT-------LTILVTDT 282
Query: 235 PDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSI---SYSTRPGWFDI 291
D DP F ++ Y S+ E+ G VLTV A DGD N ++Y + S + F+I
Sbjct: 283 NDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEI 342
Query: 292 GA-DGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHK 350
GVIR G +DRE++ E QL V A++ + + +++++V D ND+
Sbjct: 343 DPRSGVIRTRGPVDREEV----ESYQLTVEASDQGRDPGPRSTTAAVFLSVE--DDNDNA 396
Query: 351 PEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGG 410
P+F ++ + V E +P P+ L + D DKGSN S+
Sbjct: 397 PQF--------------SEKRYVVQVREDVTPGAPV--LRVTASDRDKGSNAVVHYSIMS 440
Query: 411 PDAEA-FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS--VAMVT 467
+A F + + A + V + +DYE ++V A D S +VT
Sbjct: 441 GNARGQFYLDAQTGA--------LDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVT 492
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGAD 527
+ + DIND+ P F + + TV E G +V + A D D G ++ Y L G G D
Sbjct: 493 VQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH-VQAIDADAGDNARLEYRLA-GVGHD 550
Query: 528 L-FQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAP 584
F ++ +G ++V LDRE Y ++A D G L++S ++ + +LD+NDN P
Sbjct: 551 FPFTINNGTGWISV--AAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNP 608
Query: 585 VVSG-SYNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTG- 640
+ Y + + E+ G VT+ A D D +S + + + G + FS+ +G
Sbjct: 609 TFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITSGNTRNRFSITSQSGG 664
Query: 641 -LLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK---VNVTITVEDINDNLPIFN 696
L+ PLD + LE + VL V SD GT+ + + V D N + P+F
Sbjct: 665 GLVSLALPLDYK-----LERQYVLAVTASD------GTRQDTAQIVVNVTDANTHRPVFQ 713
Query: 697 QSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAE 755
S Y V E+ P G V ++ A D D E N RI++ + S + + AE
Sbjct: 714 SSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIPQFRIDADTGAVTTQAE 772
Query: 756 GYLRLPPDVSLDYETQPVFNLTVSA-ENPDPQGGETI-VDVCVNVKDVNDNPPTLDVASL 813
LDYE Q + L ++A +N PQ +T +++ VN DVNDN P S
Sbjct: 773 ----------LDYEDQVSYTLAITARDNGIPQKSDTTYLEILVN--DVNDNAPQFLRDSY 820
Query: 814 RGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGS 873
+G V E+ V + A+D D+ + T G D G G F V +
Sbjct: 821 QG-SVYEDVPPFTSVLQISATDRDSGLN-----GRVFYTFQGGDDGD---GDFIVESTSG 871
Query: 874 VYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
+ + + +D E ++ V+RA A D G + +T+ DVNDN P F +++
Sbjct: 872 I-VRTLRRLDRE--NVAQYVLRA--YAVDKGMPPARTPMEVTVTVLDVNDNPPVF-EQDE 925
Query: 934 TFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSS 993
V + E VA V A D D G N I++ I+ IP +F
Sbjct: 926 FDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE--------GNIP-----EVF--- 969
Query: 994 EADVFAGSIQPVTSLDSTLQGTYQVTVQARDRP 1026
+ D+F+G + + LD + Y + +QA P
Sbjct: 970 QLDIFSGELTALVDLDYEDRPEYVLVIQATSAP 1002
Score = 186 bits (473), Expect = 1e-46
Identities = 205/732 (28%), Positives = 322/732 (43%), Gaps = 96/732 (13%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYG-MSGPNAYFFAVTPKTGE 78
AP+F V + ED+ GA + A D+D N + Y MSG F + +TG
Sbjct: 396 APQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA 455
Query: 79 VKLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSIN 134
+ + S LDYET + + + D P V + V V D NDNAP+F +T F ++
Sbjct: 456 LDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVL 515
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN---GSIVLNGSL 191
E++P+G +V V A+D D G + Y + V H F N G I + L
Sbjct: 516 ESVPLGYLVLHVQAIDADAGDNARLEYRLAGV-------GHDFPFTINNGTGWISVAAEL 568
Query: 192 SYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVA 251
+ FY ++A D H T + S V S++V+D D +P F + Y+ +
Sbjct: 569 D-REEVDFYSFGVEARD-----HGTPALTASASV--SVTVLDVNDNNPTFTQPEYTVRLN 620
Query: 252 EDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI---GADGVIRVNGSLDREQL 308
EDAA GTSV+TV AVD D + + Y I+ F I G++ + LD
Sbjct: 621 EDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLD---- 674
Query: 309 LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEA 368
+ + + L VTA++ Q + V V D N H+P F +
Sbjct: 675 YKLERQYVLAVTASDGTRQDTAQ-------IVVNVTDANTHRPVFQSS------------ 715
Query: 369 QVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG--TFLLSLGGPDAEAFSVSPERAAGS 426
++T V+E + + + D D G N T+ + P F + + A
Sbjct: 716 --HYTVNVNEDRPAGTTV--VLISATDEDTGENARITYFMEDSIPQ---FRIDADTGA-- 766
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
V A +DYE Q + + + A D+ + Q + I + D+ND+ P F + Y
Sbjct: 767 ------VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGAD-LFQVDPVSGTVTVRNGE 544
+V E + V I ATD D+G G++ Y+ G+ D F V+ SG VR
Sbjct: 821 QGSVYEDVPPFTSVL-QISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG--IVRTLR 877
Query: 545 LLDRESQAVYYLTLQATDGGNLSSSTTLQ--IHLLDINDNAPVV-SGSYNIFVQEEE--G 599
LDRE+ A Y L A D G + T ++ + +LD+NDN PV +++FV+E G
Sbjct: 878 RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
Query: 600 NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEG 659
+ A D DE GT N+++++ ++ G F LD +G L L LD E
Sbjct: 938 LAVARVTATDPDE-GT-NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLD-------YED 988
Query: 660 RIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQ-----SSYNFTVKEEDPGVLVG 714
R +++ P++ ++ V + + D NDN P+ ++Y PG +G
Sbjct: 989 RPEYVLVIQATSAPLV-SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIG 1047
Query: 715 VVKAWDADQTEA 726
V A D D +++
Sbjct: 1048 RVPAHDPDISDS 1059
Score = 146 bits (369), Expect = 1e-34
Identities = 159/575 (27%), Positives = 252/575 (43%), Gaps = 80/575 (13%)
Query: 12 PALVVSVAANVA--------PKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGM 62
PAL S + +V P F +V L ED VG + A D+D + +TY +
Sbjct: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQI 647
Query: 63 -SGPNAYFFAVTPKTGE--VKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRND 119
SG F++T ++G V LA LDY+ + + ++ SD Q +++V V D N
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANT 707
Query: 120 NAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI 179
+ PVFQ++ ++ ++NE P G+ V + A D+D G + Y +E IP FRI
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-------FRI 760
Query: 180 LAN-GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLD 238
A+ G++ L Y ++ + Y L + A D G Q S +L I V D D
Sbjct: 761 DADTGAVTTQAELDYEDQVS-YTLAITARDNG-------IPQKSDTTYLEILVNDVNDNA 812
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSI-SYSTRPGWFDI-GADGV 296
PQF+R+ Y SV ED TSVL + A D D G+N V Y+ G F + G+
Sbjct: 813 PQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGI 872
Query: 297 IRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNC 356
+R LDRE + + L+ A + + A+ + VTV V+DVND+ P F
Sbjct: 873 VRTLRRLDRENV----AQYVLRAYAVDKGM----PPARTPMEVTVTVLDVNDNPPVF--- 921
Query: 357 SLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEA 415
Q F +V+E++ + + +T DPD+G+N + + G E
Sbjct: 922 -----------EQDEFDVFVEENSPIGLAVARVTAT--DPDEGTNAQIMYQIVEGNIPEV 968
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR--DI 473
F + +A V +DYE + + + AT + V+ T+H+R D
Sbjct: 969 FQLDIFSGELTALVD--------LDYEDRPEYVLVIQATSAP----LVSRATVHVRLLDR 1016
Query: 474 NDHRPTFPQ-----SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADL 528
ND+ P + YV G++ + A DPD +TYS GN L
Sbjct: 1017 NDNPPVLGNFEILFNNYVTNRSSSFPGGAI--GRVPAHDPDIS--DSLTYSFERGNELSL 1072
Query: 529 FQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDG 563
++ +G + + LD +++ +DG
Sbjct: 1073 VLLNASTGELKL--SRALDNNRPLEAIMSVLVSDG 1105
Score = 79.0 bits (193), Expect = 3e-14
Identities = 103/405 (25%), Positives = 164/405 (40%), Gaps = 55/405 (13%)
Query: 693 PIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSG---SGANYFMIRGLV 748
P F SY TV E P G V ++A D D+ EA R+ +++ S +N F V
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG-RLEYTMDALFDSRSNQFFSLDPV 237
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
GA + LD ET+ V+A++ + + + V D ND+ P
Sbjct: 238 TGA--------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
+ + + EN +V V A+D D I L +L G F +
Sbjct: 290 EQQEYKE-SLRENLEVGYEVLTVRATDGDAPPNANI-LYRLLEGSGGSPSEV-----FEI 342
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
V I +D E + L V A D DPG + S ++ +++ED NDNAP F
Sbjct: 343 DPRSGV-IRTRGPVDREEVESYQLTVEASDQGRDPGPR--STTAAVFLSVEDDNDNAPQF 399
Query: 929 LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFS 988
E + V + E V P V V A D D G+N V+ +SI+ + +G F
Sbjct: 400 -SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN----------ARGQFY 448
Query: 989 IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARD--RPSLGPFLEATTTLNLFTVDQS 1046
+ D G++ V+ LD Y + V+A+D RP P + + + +D +
Sbjct: 449 L------DAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP---PLSNVSGLVTVQVLDIN 499
Query: 1047 YRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA 1091
+ + STP A + ++ ++ +Q ID+ A
Sbjct: 500 DNAPIFVSTP----------FQATVLESVPLGYLVLHVQAIDADA 534
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 223 bits (569), Expect = 7e-58
Identities = 270/998 (27%), Positives = 420/998 (42%), Gaps = 120/998 (12%)
Query: 6 LSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM 62
LS LL + V A + AP F SV +PED+P G L A D D N +TY +
Sbjct: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
Query: 63 SGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY----IQVQREMLVIVEDRN 118
A F + P +GE++ A+ALD E ++ ++S D + + + V D N
Sbjct: 1895 GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVN 1954
Query: 119 DNAPVFQNTAFSTSINETLPVGSVVFSVLAV----DKDMGSAGMVVYSIEKVIP--STGD 172
D+AP F + + P S LA D+D G+ ++Y + P +T D
Sbjct: 1955 DHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVD 2014
Query: 173 SEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
S +A + +L ++ F + A DLG + + + + +
Sbjct: 2015 SYTGEIRVARSPV----ALGPRDRVLF----IVATDLGRPARSATGV-------IIVGLQ 2059
Query: 233 DQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI- 291
+ + P+F R A++ E+A GT +++ AV G N P+ YSI G F I
Sbjct: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQ 2118
Query: 292 GADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKP 351
+ G I V + + L+ + +L++ L A +T+ + D ND+ P
Sbjct: 2119 PSTGAITVRSA----EGLDFEVSPRLRLV-----LQAESGGAFAFTVLTLTLQDANDNAP 2169
Query: 352 EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG--TFLLSLG 409
F A F PE + E ++ DDL D+GS G ++ L+
Sbjct: 2170 RFLRPHYVA--FLPESRPL-------EGPLLQVEADDL-------DQGSGGQISYSLAAS 2213
Query: 410 GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF-SVAMVTI 468
P F V P + +A++D E + ++ATD S A +T+
Sbjct: 2214 QPARGLFHVDPTTGT--------ITTTAILDREIWAETRLVLMATDRGSPALVGSATLTV 2265
Query: 469 HLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADL 528
+ D ND+RPT PQ + L V E + GS + + D D+G + Y L P D
Sbjct: 2266 MVIDTNDNRPTIPQP-WELRVSEDALLGSEIA-QVTGNDVDSGP--VLWYVLSPSGPQDP 2321
Query: 529 FQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSG 588
F V G V++ LD E Y L L A DG + L + + D+NDNAP S
Sbjct: 2322 FSVGRYGGRVSLTGP--LDFEQCDRYQLQLLAHDGPH-EGRANLTVLVEDVNDNAPAFSQ 2378
Query: 589 S-YNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRN--- 644
S Y + + E S + D N + ++L + FS+DP+ G L
Sbjct: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL--ASPADGFSVDPNNGTLFTIVG 2436
Query: 645 ---LGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYN 701
LG A+D LE R D G P + V + ++D ND+ P F S Y
Sbjct: 2437 TVALGHDGSGAVDVVLEAR--------DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYR 2488
Query: 702 FTVKEE-DPGVLVGVVKAWDADQTEANNRISFS-LSGSGANYFMIRGLVLGAGWAEG--- 756
V E+ PG + ++A DAD + ++ + +S +SG+ F + + AG + G
Sbjct: 2489 VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGP 2548
Query: 757 -----YLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVA 811
+ L P LD+E+ +NLTV+A + ++V V V V DVNDNPP A
Sbjct: 2549 RALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA 2605
Query: 812 SLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAAN 871
S R + V E+ ++ V ASD D LV + G F + +
Sbjct: 2606 SYR-VTVPEDTPVGAELLHVEASDADPGPH---GLVRFTVSSGDPS------GLFELDES 2655
Query: 872 GSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPE 931
+ + A+D E LVV+A D A A+ + I ++DVND+ P F P
Sbjct: 2656 SGT-LRLAHALDCETQARHQLVVQAADPA-----GAHFALAPVTIEVQDVNDHGPAF-PL 2708
Query: 932 NKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSIL 969
N + E P V ++ A D D+G G + +S+L
Sbjct: 2709 NLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLL 2746
Score = 222 bits (565), Expect = 2e-57
Identities = 278/958 (29%), Positives = 439/958 (45%), Gaps = 128/958 (13%)
Query: 48 LVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVKLAS---ALDYETLYTFKVTISVSD 101
L AED+D N + Y ++G V TGE+++A AL F V +
Sbjct: 1986 LRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGR 2045
Query: 102 PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVY 161
P ++V ++ + P F + +I E P G+ + S AV G+ G + Y
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITY 2104
Query: 162 SIEKVIPSTGDSEHLFRIL-ANGSIVLNGSLSYNNK-SAFYQLELKACDLGGMYHNTFTI 219
SI +G+ + F I + G+I + + + + S +L L+A + GG + FT+
Sbjct: 2105 SI-----LSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA-ESGGAF--AFTV 2156
Query: 220 QCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS 279
L++++ D D P+F+R Y A + E +L VEA D D+G + YS
Sbjct: 2157 -------LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYS 2209
Query: 280 ISYSTRP-GWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKV-S 336
++ S G F + G I LDRE E +L + AT+ G A V S
Sbjct: 2210 LAASQPARGLFHVDPTTGTITTTAILDREIWAET----RLVLMATDR-----GSPALVGS 2260
Query: 337 IWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDP 396
+TV V+D ND++P ++P P E +V+ + + + D
Sbjct: 2261 ATLTVMVIDTNDNRP-----TIPQ----PWELRVSEDALLGSEIAQ--------VTGNDV 2303
Query: 397 DKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS 456
D G ++LS GP + FSV R G S+ + +D+E+ +Q++A D
Sbjct: 2304 DSGPVLWYVLSPSGPQ-DPFSVG--RYGGRVSL------TGPLDFEQCDRYQLQLLAHDG 2354
Query: 457 VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQI 516
+ A +T+ + D+ND+ P F QSLY + + EH+ GS + S+ ATD D+GA G I
Sbjct: 2355 PHEGR--ANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL-SVSATDRDSGANGHI 2411
Query: 517 TYSLLPGNGADLFQVDPVSGTV-TVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQ 573
+Y L + AD F VDP +GT+ T+ L + + L+A D G ++ T+
Sbjct: 2412 SYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVH 2469
Query: 574 IHLLDINDNAPVVSGS-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYS 630
+ L D ND+AP + S Y + V E+ G+ +T++A D D +++ + ++++ G +
Sbjct: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADG-SRSHAAVDYSIISGNWG 2528
Query: 631 HNFSLDPDT--------------GLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
F L+P G L L PLD E++ + LTV +D G+P
Sbjct: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLT-----QYNLTVAAADRGQPPQS 2583
Query: 677 TKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSL- 734
+ V VT+TV D+NDN P+F ++SY TV E+ P G + V+A DAD + + F++
Sbjct: 2584 SVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDAD-PGPHGLVRFTVS 2642
Query: 735 SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGE-TIVD 793
SG + F + + G LRL +LD ETQ L V A DP G +
Sbjct: 2643 SGDPSGLFEL-------DESSGTLRLAH--ALDCETQARHQLVVQA--ADPAGAHFALAP 2691
Query: 794 VCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSA--QLEIQLVNILC 851
V + V+DVND+ P + +L VAEN V + A D D A +L L
Sbjct: 2692 VTIEVQDVNDHGPAFPL-NLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSL----- 2745
Query: 852 TKAGVDVGSLCWGWFSVAANGSV-YINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSN 910
++ G G + A N S + DYE + L+V A D G + S
Sbjct: 2746 ----LEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVG----AADAGNLSASV 2797
Query: 911 NGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
S+L+T ED D P FL F +PE + V+A D+D G +G++L+S+
Sbjct: 2798 TVSVLVTGEDEYD--PVFLAPAFHFQ-VPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 216 bits (550), Expect = 1e-55
Identities = 260/972 (26%), Positives = 413/972 (42%), Gaps = 99/972 (10%)
Query: 14 LVVSVAA--NVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY 68
L VSVA + AP F SV+L E+ P G L A D D N +TYG G ++
Sbjct: 1635 LTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG--GVSSE 1692
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQ 125
F++ P TG + ALD E +T+ D P + V VED ND+AP F
Sbjct: 1693 SFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFG 1752
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGS 184
+ S + E ++ + A D D+G+ G + Y I GD F + LA+G
Sbjct: 1753 SAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRI-----LDGDPSGAFVLDLASGE 1806
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVRE 244
L + AF QL ++A D G S + L+++V+D D P F
Sbjct: 1807 FGTMRPLDREVEPAF-QLRIEARDGGQP-------ALSATLLLTVTVLDANDHAPAFPVP 1858
Query: 245 FYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLD 304
YS V ED GT +L ++A D D G N V Y + T + + G +R +LD
Sbjct: 1859 AYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALD 1918
Query: 305 REQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFT 364
REQ V A L+ ++ VT+ V DVNDH P TF
Sbjct: 1919 REQCPSYTFSVSAVDGAAAGPLS-------TTVSVTITVRDVNDHAP----------TFP 1961
Query: 365 PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAA 424
++ ++P + + T+ D D G+N + L L G +V +
Sbjct: 1962 TSPLRLRLPRPGPSFSTPTLAL--ATLRAEDRDAGANASILYRLAGTPPPGTTVD----S 2015
Query: 425 GSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQS 483
+ ++V AL +R + +VATD + ++ + L+ + P FP++
Sbjct: 2016 YTGEIRVARSPVALGPRDR----VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRA 2071
Query: 484 LYVLTVPEHSATGSVVTD--SIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
T+ E++ G+ + ++HA G G ITYS+L GN F + P +G +TVR
Sbjct: 2072 SSEATIRENAPPGTPIVSPRAVHA----GGTNGPITYSILSGNEKGTFSIQPSTGAITVR 2127
Query: 542 NGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEEGN 600
+ E LD E L LQA GG + T L + L D NDNAP + Y F+ E
Sbjct: 2128 SAEGLDFEVSPRLRLVLQAESGGAF-AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPL 2186
Query: 601 VSVTIQAHDNDEPGTNNSRLLFNLLPG-PYSHNFSLDPDTGLLRNLGPLDREAIDPALEG 659
+Q +D + ++ ++L P F +DP TG + LDRE E
Sbjct: 2187 EGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREI---WAET 2243
Query: 660 RIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAW 719
R+VL + +D G P L +T+ V D NDN P Q + ++ + +L +
Sbjct: 2244 RLVL--MATDRGSPALVGSATLTVMVIDTNDNRPTIPQP---WELRVSEDALLGSEIAQV 2298
Query: 720 DADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVS 779
+ ++ + + LS SG G G R+ LD+E + L +
Sbjct: 2299 TGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG--------RVSLTGPLDFEQCDRYQLQLL 2350
Query: 780 AENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTS 839
A + +G ++ V V+DVNDN P SL + + E+ + V A+D D+
Sbjct: 2351 AHDGPHEGR---ANLTVLVEDVNDNAPAFS-QSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
Query: 840 AQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVY-INQSKAIDYEACDLVTLVVRACD 898
A I + S G+ NG+++ I + A+ ++ V +V+
Sbjct: 2407 ANGHI----------SYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLE--- 2453
Query: 899 LATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARD-DD 957
A D G + ++ + ++D ND+AP F + V + E + P + ++ A D D
Sbjct: 2454 -ARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYR-VAVTEDLPPGSTLLTLEATDADG 2511
Query: 958 SGNNGVILFSIL 969
S ++ + +SI+
Sbjct: 2512 SRSHAAVDYSII 2523
Score = 206 bits (524), Expect = 1e-52
Identities = 258/922 (27%), Positives = 390/922 (42%), Gaps = 103/922 (11%)
Query: 71 AVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
A+ +G V+ A LD E ++ T D E+ V V D ND+AP F +
Sbjct: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDG---ATVEVTVRVADINDHAPAFPQARAA 149
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN-------- 182
+ E G+ A D D G G Y++ S + FR+
Sbjct: 150 LQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL-----SGDGAGETFRLETRPGPDGTPV 204
Query: 183 GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242
+V+ G L N+S Y L+L+A D G L ++++D D P F
Sbjct: 205 PELVVTGELDRENRS-HYMLQLEAYDGGSPPRRA-------QALLDVTLLDINDHAPAFN 256
Query: 243 REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSIS--YSTRPGWFDIGA-DGVIRV 299
+ Y A V+E A G+ VL V A D D G+N V Y I+ S G F I A G++++
Sbjct: 257 QSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQL 316
Query: 300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD EQ + VQ + L S +VTV V D ND++P L
Sbjct: 317 ERPLDFEQRRVHELVVQARDGGAHPELG--------SAFVTVHVRDANDNQPSMTVIFLS 368
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
A + + V E A P + ++ V DPD G +SL G + F++S
Sbjct: 369 A----------DGSPQVSEAAPPGQLVARIS--VSDPDDGDFAHVNVSLEGGEGH-FALS 415
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF-SVAMVTIHLRDINDHRP 478
+ SV LV V+ +D E + A ++V ATDS S + A +H+ D+ND+ P
Sbjct: 416 TQ-----DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAP 470
Query: 479 TFPQSLY-VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGT 537
F + LY +PE + GS V + A DPD G GQ+TYSL PG F +DP SG
Sbjct: 471 AFDRQLYRPEPLPEVALPGSFVV-RVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGI 529
Query: 538 VTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSGS-YNIFV 594
+T LD E + L + ATDGG L+SS T+ + L D+NDN P + YN +
Sbjct: 530 IT--TAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASL 587
Query: 595 QE--EEGNVSVTIQAHDNDE-PGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDRE 651
E + G + + A D D P S L L S F +D +G + LDR+
Sbjct: 588 PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD 647
Query: 652 AIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK-EEDPG 710
+ + TV D G L + V V + + D NDN P F Y ++ + PG
Sbjct: 648 QGPSSFD----FTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPG 701
Query: 711 VLVGVVKAWDADQTEANNRISFS-LSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLD 767
V ++A D DQ ++ R+S+ L+G+ F + + +L W L
Sbjct: 702 TAVLRLRAHDPDQ-GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAW-----------PLA 749
Query: 768 YETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQ 827
V L + AE+ E V +++ PP + V E+ +
Sbjct: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQY-VFSVPEDVAPGTS 808
Query: 828 VAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEAC 887
V +V A + +L + + +G D G FS+ A + + + +D E
Sbjct: 809 VGIVQAHNPPG------RLAPVTLSLSGGDPR----GLFSLDAVSGL-LQTLRPLDRELL 857
Query: 888 DLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNRE 947
V + P F + + ++DVNDN+P F P + V++P P
Sbjct: 858 GPVLELEVRAGSGVPPAFAV----ARVRVLLDDVNDNSPAF-PAPEDTVLLPPNTAPGTP 912
Query: 948 VASVRARDDDSGNNGVILFSIL 969
+ ++RA D DSG N + F++L
Sbjct: 913 IYTLRALDPDSGVNSRVTFTLL 934
Score = 205 bits (522), Expect = 2e-52
Identities = 280/1058 (26%), Positives = 434/1058 (41%), Gaps = 141/1058 (13%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYG-MSGPNAYFFAVTPKTGE 78
AP F + S+ +PE L A D D N L Y + G + F + +GE
Sbjct: 1748 APTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGE 1806
Query: 79 VKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
LD E F++ I D P + + V V D ND+AP F A+S + E
Sbjct: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPE 1866
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNN 195
+P G+++ + A D D G+ G V Y + G + ++G + +L
Sbjct: 1867 DVPAGTLLLQLQAHDPDAGANGHVTYYL-----GAGTAGAFLLEPSSGELRTAAALD-RE 1920
Query: 196 KSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF----VREFYSASVA 251
+ Y + A D S V ++I+V D D P F +R
Sbjct: 1921 QCPSYTFSVSAVD------GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 1974
Query: 252 EDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEA 311
+ ++ T+ A D D G N ++Y ++ + PG G IRV R +
Sbjct: 1975 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVA----RSPVALG 2030
Query: 312 DEEVQLQVTATETHLNIYGQEAKVSIWVT-VRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
+ L + AT+ G+ A+ + V V + + P F S A
Sbjct: 2031 PRDRVLFIVATDL-----GRPARSATGVIIVGLQGEAERGPRFPRASSEAT--------- 2076
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS-LGGPDAEAFSVSPERAAGSASV 429
+ E+A P PI V G+NG S L G + FS+ P A
Sbjct: 2077 -----IRENAPPGTPIVSPRAVHAG---GTNGPITYSILSGNEKGTFSIQPSTGA----- 2123
Query: 430 QVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTV 489
+ VR + +D+E + + + A + F+ ++T+ L+D ND+ P F + YV +
Sbjct: 2124 -ITVRSAEGLDFEVSPRLRLVLQAESGGA--FAFTVLTLTLQDANDNAPRFLRPHYVAFL 2180
Query: 490 PEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA-DLFQVDPVSGTVTVRNGELLDR 548
PE + + A D D G+ GQI+YSL A LF VDP +GT+T +LDR
Sbjct: 2181 PESRPLEGPLLQ-VEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTT--AILDR 2237
Query: 549 ESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQ 606
E A L L ATD G+ L S TL + ++D NDN P + + + V E+ S Q
Sbjct: 2238 EIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQ 2297
Query: 607 AHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVL 666
ND + L + L P FS+ G + GPLD E D R L +L
Sbjct: 2298 VTGNDVD--SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCD-----RYQLQLL 2350
Query: 667 VSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTE 725
D P G + N+T+ VED+NDN P F+QS Y + E P G + V A D D +
Sbjct: 2351 AHD--GPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD-SG 2406
Query: 726 ANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL-RLPPDVSLDYETQPVFNLTVSAENPD 784
AN IS+ L+ S A+ F + G L + V+L ++ ++ + A +
Sbjct: 2407 ANGHISYHLA-SPADGFSVDP-------NNGTLFTIVGTVALGHDGSGAVDVVLEARDHG 2458
Query: 785 PQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEI 844
G V V ++D ND+ P+ ++ R + V E+ + + A+D D S
Sbjct: 2459 APGRAARATVHVQLQDQNDHAPSFTLSHYR-VAVTEDLPPGSTLLTLEATDADGSR---- 2513
Query: 845 QLVNILCTKAGVDVGSLCWGWFSV------------------AANGSVYINQSKAIDYEA 886
+ A VD + W V A G + + + +D+E+
Sbjct: 2514 -------SHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP--LDFES 2564
Query: 887 CDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNR 946
L V A D P S+ + +T+ DVNDN P F + V +PE
Sbjct: 2565 LTQYNLTVAAADRGQPP----QSSVVPVTVTVLDVNDNPPVFTRASYR-VTVPEDTPVGA 2619
Query: 947 EVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVT 1006
E+ V A D D G +G++ F++ D G+F E D +G+++
Sbjct: 2620 ELLHVEASDADPGPHGLVRFTVSSGDP----------SGLF------ELDESSGTLRLAH 2663
Query: 1007 SLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
+LD Q +Q+ VQA D P+ F A T+ + V+
Sbjct: 2664 ALDCETQARHQLVVQAAD-PAGAHFALAPVTIEVQDVN 2700
Score = 189 bits (479), Expect = 2e-47
Identities = 240/819 (29%), Positives = 358/819 (43%), Gaps = 101/819 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLT---YGMSGPNA-YFFAVTPKTG- 77
AP F ++ +PE G + A D D L Y +SG A F + + G
Sbjct: 140 APAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGP 199
Query: 78 ------EVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTA 128
E+ + LD E + + + D P + Q + V + D ND+AP F +
Sbjct: 200 DGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSR 259
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN-GSIVL 187
+ ++E+L GS V V A D D G G V Y I + S GD F I A+ G + L
Sbjct: 260 YHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINR-RQSEGDGP--FSIDAHTGLLQL 316
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
L + + ++L ++A D GG + + F+++ V D D P F S
Sbjct: 317 ERPLDFEQRRV-HELVVQARD-GGAHPELGS------AFVTVHVRDANDNQPSMTVIFLS 368
Query: 248 A----SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIR---V 299
A V+E A G V + D D G D ++S G F + D VI V
Sbjct: 369 ADGSPQVSEAAPPGQLVARISVSDPDDG--DFAHVNVSLEGGEGHFALSTQDSVIYLVCV 426
Query: 300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LDRE+ + L+VTAT++ EA + VT DVND+ P F
Sbjct: 427 ARRLDREE----RDAYNLRVTATDSGSPPLRAEAAFVLHVT----DVNDNAPAF------ 472
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG-GPDAEAFSV 418
+ Q+ + E A P + + + DPD+G+NG SL G FS+
Sbjct: 473 -------DRQLYRPEPLPEVALPGSFV--VRVTARDPDQGTNGQVTYSLAPGAHTHWFSI 523
Query: 419 SPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHR 477
P ++ +A +DYE + + VVATD + S A V++ L+D+ND+
Sbjct: 524 DPTSG--------IITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNE 575
Query: 478 PTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSL---LPGNGADLFQVDPV 534
P F ++ Y ++PE + G+ + ATD D+G +G ++YSL L +G+ F++D
Sbjct: 576 PQFQRTFYNASLPEGTQPGTCFL-QVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAH 634
Query: 535 SGTVTVRNGELLDR-ESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV---SGSY 590
SG V LDR + + + T+ A DGG L S +++ L D NDN P +
Sbjct: 635 SGDVCTT--RTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAA 692
Query: 591 NIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDR 650
+I Q G + ++AHD D+ ++ RL +++L G F+LD +GLL PL R
Sbjct: 693 SISAQSPPGTAVLRLRAHDPDQ--GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLAR 750
Query: 651 EAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DP 709
A + L + D G V I++ PIF Q Y F+V E+ P
Sbjct: 751 RA-----NSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAP 805
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR-LPPDVSLDY 768
G VG+V+A + A ++ SLSG RGL G L+ L P LD
Sbjct: 806 GTSVGIVQAHNPPGRLA--PVTLSLSGGDP-----RGL-FSLDAVSGLLQTLRP---LDR 854
Query: 769 E-TQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
E PV L V A + P + V V + DVNDN P
Sbjct: 855 ELLGPVLELEVRAGSGVPP-AFAVARVRVLLDDVNDNSP 892
Score = 181 bits (458), Expect = 5e-45
Identities = 205/796 (25%), Positives = 342/796 (42%), Gaps = 80/796 (10%)
Query: 35 LPEDLPVGAQAFWLVAEDQD---NDPLTYGMS-GPNAYFFAVTPKTGEVKLASALDYETL 90
LPE G+ + A D D N +TY ++ G + ++F++ P +G + A++LDYE
Sbjct: 482 LPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELE 541
Query: 91 YTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL 147
++ + +D P + + V ++D NDN P FQ T ++ S+ E G+ V
Sbjct: 542 PQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
Query: 148 AVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYNNKSAFYQLELKA 206
A D D G G++ YS+ + S+G FRI A +G + +L + + + + A
Sbjct: 602 ATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTA 659
Query: 207 CDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAV 266
D GG+ + + VFLS D+ D PQF Y+AS++ + GT+VL + A
Sbjct: 660 VDGGGLKSMVY-----VKVFLS----DENDNPPQFYPREYAASISAQSPPGTAVLRLRAH 710
Query: 267 DGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETH 325
D D+G + + Y I P F + G++ V L R A+ VQL++ A +
Sbjct: 711 DPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLAR----RANSVVQLEIGAEDGG 766
Query: 326 LNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIP 385
G +A+ S V + + +P P Q+ + V E +P
Sbjct: 767 ----GLQAEPSARVDISI--------------VPGTPTPPIFEQLQYVFSVPEDVAPGTS 808
Query: 386 IDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYE-RQ 444
+ +V G LSL G D P +V L++ +D E
Sbjct: 809 VG---IVQAHNPPGRLAPVTLSLSGGD-------PRGLFSLDAVSGLLQTLRPLDRELLG 858
Query: 445 TAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIH 504
+ ++V A V F+VA V + L D+ND+ P FP + +P ++A G+ + ++
Sbjct: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY-TLR 917
Query: 505 ATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG 564
A DPD+G ++T++LL G G F VDP +G V + L + L L+A DGG
Sbjct: 918 ALDPDSGVNSRVTFTLLAGGGG-AFTVDPTTGHVRLMRP--LGPSGGPAHELELEARDGG 974
Query: 565 N--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLF 622
+ +S L++ + D+ + + + + Q + + +
Sbjct: 975 SPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITY 1034
Query: 623 NLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK---V 679
+L S F L+P +G L LDREA + +L V+ + LG +
Sbjct: 1035 HLAAEGASSPFGLEPQSGWLWVRAALDREA-----QELYILKVMAVSGSKAELGQQTGTA 1089
Query: 680 NVTITVEDINDNLPIFNQSSYNFTVKE-EDPGVLVGVVKAWDADQTEANNRISFSLS--G 736
V +++ + N++ P ++ V E + PG VG V A D D + N R+++SL
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGRLTYSLQQLS 1148
Query: 737 SGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCV 796
+ F I + +LD E Q + L V ++ T V V
Sbjct: 1149 EDSKAFRIHPQTGEVTTLQ---------TLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV 1199
Query: 797 NVKDVNDNPPTLDVAS 812
V D+NDN PT AS
Sbjct: 1200 AVLDLNDNSPTFLQAS 1215
Score = 172 bits (435), Expect = 2e-42
Identities = 177/634 (27%), Positives = 289/634 (45%), Gaps = 80/634 (12%)
Query: 37 EDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF--FAVTPKTGEVKLASALDYETLYTFK 94
ED +G++ + D D+ P+ + + P+ F+V G V L LD+E ++
Sbjct: 2287 EDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ 2346
Query: 95 VTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMG 154
+ + D + + + V+VED NDNAP F + + + E P GS + SV A D+D G
Sbjct: 2347 LQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
Query: 155 SAGMVVYSIE------KVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACD 208
+ G + Y + V P+ G LF I+ G++ L ++ S + L+A D
Sbjct: 2407 ANGHISYHLASPADGFSVDPNNGT---LFTIV--GTVALG-----HDGSGAVDVVLEARD 2456
Query: 209 LGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDG 268
G + + + + DQ D P F Y +V ED G+++LT+EA D
Sbjct: 2457 HGAPGR-------AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDA 2509
Query: 269 DKGINDPVI-YSI-------SYSTRPGWFDIG--ADGVIRVNGSLDREQLLEADEEVQLQ 318
D + + YSI + P + G A R G L + L+ + Q
Sbjct: 2510 DGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYN 2569
Query: 319 VTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378
+T Q + V VTV V+DVND+ P F S PE+ V
Sbjct: 2570 LTVAAADRGQPPQSSVVP--VTVTVLDVNDNPPVFTRASYRVT--VPEDTPVG------- 2618
Query: 379 HASPRIPIDDLTMVVYDPDKGSNG--TFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVS 436
+ L + D D G +G F +S G P F + + ++G+ +R++
Sbjct: 2619 -------AELLHVEASDADPGPHGLVRFTVSSGDPSG-LFEL--DESSGT------LRLA 2662
Query: 437 ALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATG 496
+D E Q + V A D +F++A VTI ++D+NDH P FP +L +V E+ G
Sbjct: 2663 HALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPG 2722
Query: 497 SVVTDSIHATDPDTGAWGQITYSLL---PG-NGADLFQVDPVSGTVTVRNGELLDRESQA 552
++VT ++HA D D GA+G++ YSLL PG G + F ++ +G + R D E
Sbjct: 2723 TLVT-TLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRAR--VPFDYEHTE 2779
Query: 553 VYYLTLQATDGGNLSSSTTLQIHLLDINDNAPV-VSGSYNIFVQE--EEGNVSVTIQAHD 609
+ L + A D GNLS+S T+ + + ++ PV ++ +++ V E G+ +QA
Sbjct: 2780 SFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA-- 2837
Query: 610 NDEPGTNNSRLLFNL-LPGPYSHNFSLDPDTGLL 642
DE G + +L++L PY F ++ TG L
Sbjct: 2838 TDEDGGADGLVLYSLATSSPY---FGINQTTGAL 2868
Score = 164 bits (416), Expect = 4e-40
Identities = 262/1060 (24%), Positives = 425/1060 (40%), Gaps = 141/1060 (13%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
+P F A +V+LP + G + L A D D N +T+ + F V P TG V
Sbjct: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHV 950
Query: 80 KLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDN--APVFQNTAFSTSIN 134
+L L ++ + D P + V+V+D AP F + + +
Sbjct: 951 RLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLP 1010
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYN 194
G+ V V A D G + Y + + G S +G + + +L
Sbjct: 1011 SGTTAGTQVLQVQAQAPD---GGPITYHLA----AEGASSPFGLEPQSGWLWVRAALD-R 1062
Query: 195 NKSAFYQLELKACDLG----GMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASV 250
Y L++ A G T T++ +S+++Q + P+ + +V
Sbjct: 1063 EAQELYILKVMAVSGSKAELGQQTGTATVR--------VSILNQNEHSPRLSEDPTFLAV 1114
Query: 251 AEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGW-FDIGAD-GVIRVNGSLDREQL 308
AE+ GTSV V A D D G N + YS+ + F I G + +LDREQ
Sbjct: 1115 AENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQ 1174
Query: 309 LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEA 368
VQ+Q + + V V V+D+ND+ P F S A
Sbjct: 1175 SSYQLLVQVQDGGSPPR--------STTGTVHVAVLDLNDNSPTFLQASGAA-------- 1218
Query: 369 QVNFTGYVDEHASPRIPIDDL--TMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGS 426
G + R+P L T+ DPD+G NGT L +L GP +E FS+ P
Sbjct: 1219 ----GGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGE-- 1272
Query: 427 ASVQVLVRVSALVDYER-QTAMAVQVVATDSVSQNFSVAMVTIHL---------RDINDH 476
L+ + L+ ER + + S ++ S+ ++ L D+ +
Sbjct: 1273 -----LLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAER 1327
Query: 477 RPTFPQSLYV-LTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGAD-LFQVDPV 534
P P + + +T E GS++ S+ A P+ G +TY+L+ G + F +D
Sbjct: 1328 DPAAPVPVVLTVTAAEGLRPGSLL-GSVAA--PEPAGVGALTYTLVGGADPEGTFALDAA 1384
Query: 535 SGTVTVRNGELLDRESQAVY-YLTLQAT-DGGNLSSSTTLQIHLLDINDNAPVVSG---S 589
SG + + LD E+ + LT++A GG + +Q+ + D N++AP + +
Sbjct: 1385 SGRLYL--ARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLA 1442
Query: 590 YNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLD 649
+ E G T +A D D PG N+ L P LD TG L LD
Sbjct: 1443 LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLD 1502
Query: 650 REAIDPALEGRIVLTVLVSDCGEPV-----LGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
RE PA L +LV P +V+ + V D NDN P+F S
Sbjct: 1503 RET-TPA------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLP 1555
Query: 705 KEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDV 764
+++ PG V A D D EA R+S+ L+ G +F + + G L + +
Sbjct: 1556 EDQPPGPAALHVVARDPDLGEA-ARVSYRLASGGDGHFRLHS-------STGALSVVRPL 1607
Query: 765 SLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQ 824
+ + V + S P+ + + V+V DVND PT + + EN
Sbjct: 1608 DREQRAEHVLTVVASDHGSPPRSATQV--LTVSVADVNDEAPTFQQQEY-SVLLRENNPP 1664
Query: 825 HGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDY 884
+ + A+D D A ++ T GV S FS+ + V + +A+D
Sbjct: 1665 GTSLLTLRATDPDVGANGQV-------TYGGVSSES-----FSLDPDTGV-LTTLRALDR 1711
Query: 885 EACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLP 944
E + + L V A D + P + ++ + +ED ND+AP F + + + +PE P
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQL----THVTVRVAVEDENDHAPTFGSAHLS-LEVPEGQDP 1766
Query: 945 NREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQP 1004
+ + +RA D D G NG + + IL D GA + D+ +G
Sbjct: 1767 -QTLTMLRASDPDVGANGQLQYRILDGD---PSGAFV-------------LDLASGEFGT 1809
Query: 1005 VTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
+ LD ++ +Q+ ++ARD P L AT L + +D
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ--PALSATLLLTVTVLD 1847
Score = 146 bits (368), Expect = 1e-34
Identities = 206/739 (27%), Positives = 298/739 (40%), Gaps = 124/739 (16%)
Query: 271 GINDPVIYSISYSTRPGWFDIGAD-------GVIRVNGSLDREQLLEADEEVQLQVTATE 323
G P++Y IS G +G D GV+R LDREQ + + TA
Sbjct: 71 GTAAPLMYFISAQEGSG---VGTDLAIDEHSGVVRTARVLDREQ------RDRYRFTAVT 121
Query: 324 THLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHAS-- 381
++ VTVRV D+NDH P F Q V EH +
Sbjct: 122 PD--------GATVEVTVRVADINDHAPAF--------------PQARAALQVPEHTAFG 159
Query: 382 PRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDA-EAFSVSPERAAGSASVQVLVRVSALVD 440
R P++ D D G GT +L G A E F + V LV V+ +D
Sbjct: 160 TRYPLEP----ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELV-VTGELD 214
Query: 441 YERQTAMAVQVVATDSVS-QNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVV 499
E ++ +Q+ A D S + A++ + L DINDH P F QS Y V E A GS V
Sbjct: 215 RENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPV 274
Query: 500 TDSIHATDPDTGAWGQITYSL--LPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLT 557
+ A+D D G G +TY + G F +D +G + + LD E + V+ L
Sbjct: 275 L-QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERP--LDFEQRRVHELV 331
Query: 558 LQATDGGNLS--SSTTLQIHLLDINDNAPVVS-------GSYNIFVQEEEGNVSVTIQAH 608
+QA DGG S + +H+ D NDN P ++ GS + G + I
Sbjct: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391
Query: 609 DNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLL------RNLGPLDREAIDPALEGRIV 662
D D+ + + L G H F+L ++ R L +R+A +
Sbjct: 392 DPDDGDFAHVNV---SLEGGEGH-FALSTQDSVIYLVCVARRLDREERDAYN-------- 439
Query: 663 LTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED--PGVLVGVVKAWD 720
L V +D G P L + + V D+NDN P F++ Y E PG V V A D
Sbjct: 440 LRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARD 499
Query: 721 ADQTEANNRISFSLS-GSGANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYETQPVFNL 776
DQ N ++++SL+ G+ ++F I G++ A SLDYE +P L
Sbjct: 500 PDQ-GTNGQVTYSLAPGAHTHWFSIDPTSGIITTA------------ASLDYELEPQPQL 546
Query: 777 TVSAENPDPQGGETIVDVCVNVKDVNDNPP----TLDVASLRGIRVAENGSQHGQVAV-V 831
V A + + V V ++DVNDN P T ASL G+Q G + V
Sbjct: 547 IVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASL------PEGTQPGTCFLQV 600
Query: 832 VASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLV 890
A+D D+ +L G +GS F + A +G V ++ D
Sbjct: 601 TATDADSGP------FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFD 654
Query: 891 TLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVAS 950
V A D G + + + + D NDN P F P I + P V
Sbjct: 655 FTVT-----AVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSP-PGTAVLR 706
Query: 951 VRARDDDSGNNGVILFSIL 969
+RA D D G++G + + IL
Sbjct: 707 LRAHDPDQGSHGRLSYHIL 725
Score = 143 bits (360), Expect = 1e-33
Identities = 166/596 (27%), Positives = 254/596 (42%), Gaps = 82/596 (13%)
Query: 466 VTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPD-TGAWGQITYSLLPGN 524
V + ++D N+H P F + L +PE+ G+ + + A+D D G + Y LL
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALY-TFRASDADGPGPNSDVRYRLLRQE 1480
Query: 525 G-ADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATD-----GGNLSSSTTLQIHLLD 578
++D +G ++ G LDRE+ L ++ATD ++ + ++ + D
Sbjct: 1481 PPVPALRLDARTGALSAPRG--LDRETTPALLLLVEATDRPANASRRRAARVSARVFVTD 1538
Query: 579 INDNAPVVSGSYNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD 636
NDNAPV + + + E++ G ++ + A D D +R+ + L G H F L
Sbjct: 1539 ENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEA--ARVSYRLASGGDGH-FRLH 1595
Query: 637 PDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN 696
TG L + PLDRE VLTV+ SD G P +T++V D+ND P F
Sbjct: 1596 SSTGALSVVRPLDREQ-----RAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQ 1650
Query: 697 QSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAE 755
Q Y+ ++E + PG + ++A D D GAN G V G +
Sbjct: 1651 QQEYSVLLRENNPPGTSLLTLRATDPD--------------VGAN-----GQVTYGGVSS 1691
Query: 756 GYLRLPPDV-------SLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
L PD +LD E Q NLTV A++ T V V V V+D ND+ PT
Sbjct: 1692 ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTF 1751
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
A L + V E G + ++ ASD D A ++Q + +G V L G F
Sbjct: 1752 GSAHL-SLEVPE-GQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGT 1809
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ +D E L + A D G A S L +T+ D ND+AP F
Sbjct: 1810 ----------MRPLDREVEPAFQLRIE----ARDGGQPALSATLLLTVTVLDANDHAPAF 1855
Query: 929 LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFS 988
P V +PE V + ++A D D+G NG + + + GA G F
Sbjct: 1856 -PVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL---------GAGT--AGAFL 1903
Query: 989 IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
+ SS G ++ +LD +Y +V A D + GP L T ++ + D
Sbjct: 1904 LEPSS------GELRTAAALDREQCPSYTFSVSAVDGAAAGP-LSTTVSVTITVRD 1952
Score = 78.2 bits (191), Expect = 5e-14
Identities = 77/296 (26%), Positives = 135/296 (45%), Gaps = 30/296 (10%)
Query: 7 SCFLLPALVVSVAAN-VAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGP 65
S F L +V V +AP+F + V LP G Q + A+ D P+TY ++
Sbjct: 980 SHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAE 1039
Query: 66 NAYF-FAVTPKTGEVKLASALDYET--LYTFKVTISVSDPYIQVQRE-----MLVIVEDR 117
A F + P++G + + +ALD E LY KV ++VS ++ ++ + V + ++
Sbjct: 1040 GASSPFGLEPQSGWLWVRAALDREAQELYILKV-MAVSGSKAELGQQTGTATVRVSILNQ 1098
Query: 118 NDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLF 177
N+++P ++ E P G+ V V A D+D G G + YS++++ + F
Sbjct: 1099 NEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQL----SEDSKAF 1154
Query: 178 RILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDL 237
RI V + + YQL ++ D G +T + ++V+D D
Sbjct: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGT-------VHVAVLDLNDN 1207
Query: 238 DPQFVREFYSA------SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPG 287
P F++ +A V + GT V T++A D D+G N ++Y++ T PG
Sbjct: 1208 SPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL---TGPG 1260
Score = 47.4 bits (111), Expect = 9e-05
Identities = 41/133 (30%), Positives = 60/133 (45%), Gaps = 18/133 (13%)
Query: 900 ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSG 959
A D G L +T+ D+ND+AP F +++ ++ E + P V V A D D+G
Sbjct: 227 AYDGGSPPRRAQALLDVTLLDINDHAPAF-NQSRYHAVVSESLAPGSPVLQVFASDADAG 285
Query: 960 NNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVT 1019
NG + + I R +G G FSI D G +Q LD + +++
Sbjct: 286 VNGAVTYEINR---RQSEG-----DGPFSI------DAHTGLLQLERPLDFEQRRVHELV 331
Query: 1020 VQARD---RPSLG 1029
VQARD P LG
Sbjct: 332 VQARDGGAHPELG 344
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 214 bits (546), Expect = 3e-55
Identities = 249/947 (26%), Positives = 413/947 (43%), Gaps = 122/947 (12%)
Query: 122 PVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA 181
P F + T + E G+ V V+A D D G AG +VYS+ ++ S S LF I
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSR--SLELFSIDP 380
Query: 182 NGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF 241
++ + + L + A D G + S ++++V D+ D P F
Sbjct: 381 QSGLIRTAAALDRESMERHYLRVTAQDHGSP-------RLSATTMVAVTVADRNDHSPVF 433
Query: 242 VREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSI-----SYSTRPGWFDIGA-DG 295
+ Y ++ E+ +G +L + A DGD N + Y + + F+I G
Sbjct: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
Query: 296 VIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYN 355
+I +G +DRE + E +L V A++ + A V + +TV +D ND+ P+F
Sbjct: 494 LISTSGRVDREHM----ESYELVVEASDQGQEPGPRSATVRVHITV--LDENDNAPQF-- 545
Query: 356 CSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAE 414
++ + V E P + L + D DK +NG ++ G
Sbjct: 546 ------------SEKRYVAQVREDVRPHTVV--LRVTATDRDKDANGLVHYNIISGNSRG 591
Query: 415 AFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS--VAMVTIHLRD 472
F++ S+ ++V A +D+E + A+++ A D+ S + +I + D
Sbjct: 592 HFAID--------SLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVD 643
Query: 473 INDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVD 532
INDH P F + + ++V E++ G V I A D D G ++ YSL F ++
Sbjct: 644 INDHIPIFVSTPFQVSVLENAPLGHSVIH-IQAVDADHGENARLEYSLTGVAPDTPFVIN 702
Query: 533 PVSGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVS-GS 589
+G V+V LDRES Y+ ++A D G+ LS+S ++ + +LD+NDN P +
Sbjct: 703 SATGWVSVSGP--LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE 760
Query: 590 YNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPD--TGLLRNL 645
Y++ + E+ G V++ A D D NS + + + G + F++ GL+
Sbjct: 761 YHLRLNEDAAVGTSVVSVTAVDRDA----NSAISYQITGGNTRNRFAISTQGGVGLVTLA 816
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
PLD + E L + SD L V I + D N + P+F + Y+ +V
Sbjct: 817 LPLDYKQ-----ERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSVN 868
Query: 706 EEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDV 764
E+ P G + V+ A D D E N RI++ L + + + A L+ P
Sbjct: 869 EDRPMGSTIVVISASDDDVGE-NARITYLLEDNLPQFR------IDADSGAITLQAP--- 918
Query: 765 SLDYETQPVFNLTVSA-ENPDPQGGETI-VDVCVNVKDVNDNPPTLDVASLRGIRVAENG 822
LDYE Q + L ++A +N PQ +T V+V VN DVNDN P + G+ V+E+
Sbjct: 919 -LDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN--DVNDNAPQFVASHYTGL-VSEDA 974
Query: 823 SQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAI 882
V + A+D D A +Q + G D G F++ + + + +
Sbjct: 975 PPFTSVLQISATDRDAHANGRVQYT----FQNGEDGD----GDFTIEPTSGI-VRTVRRL 1025
Query: 883 DYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELV 942
D EA + L A D P S+ + ++DVNDNAP F P + V + E
Sbjct: 1026 DREAVSVYELTAYAVDRGVPP----LRTPVSIQVMVQDVNDNAPVF-PAEEFEVRVKENS 1080
Query: 943 LPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI 1002
+ VA + A D D G N I++ I+ IP +F + D+F+G +
Sbjct: 1081 IVGSVVAQITAVDPDEGPNAHIMYQIVE--------GNIP-----ELF---QMDIFSGEL 1124
Query: 1003 QPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRS 1049
+ LD + Y + VQA P L + T+++ VDQ+ S
Sbjct: 1125 TALIDLDYEARQEYVIVVQATSAP-----LVSRATVHVRLVDQNDNS 1166
Score = 209 bits (533), Expect = 1e-53
Identities = 237/847 (27%), Positives = 350/847 (41%), Gaps = 83/847 (9%)
Query: 19 AANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYG----MSGPNAYFFA 71
AAN P+F ++PE+ G +VA+D D L Y M+ + F+
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 72 VTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTA 128
+ P++G ++ A+ALD E++ + ++ D P + + V V DRND++PVF+
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLN 188
+ ++ E + G + + A D D + Y + + F I ++
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA 248
Y+L ++A D G S V + I+V+D+ D PQF + Y A
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPR-----SATVRVHITVLDENDNAPQFSEKRYVA 552
Query: 249 SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQ 307
V ED T VL V A D DK N V Y+I G F I + G I+V LD
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLD--- 609
Query: 308 LLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEE 367
EA+ E L++ A + ++ +++V+D+NDH P F + TP
Sbjct: 610 -FEAEREYALRIRAQDAGRPPLSNNTGLA---SIQVVDINDHIPIFVS--------TP-- 655
Query: 368 AQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSA 427
F V E+A + + V D D G N SL G V+P+
Sbjct: 656 ----FQVSVLENAPLGHSVIHIQAV--DADHGENARLEYSLTG-------VAPDTPFVIN 702
Query: 428 SVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV-AMVTIHLRDINDHRPTFPQSLYV 486
S V VS +D E V A D S S A VT+ + D+ND+RP F Y
Sbjct: 703 SATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYH 762
Query: 487 LTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELL 546
L + E +A G+ V S+ A D D + I+Y + GN + F + G V L
Sbjct: 763 LRLNEDAAVGTSVV-SVTAVDRDANS--AISYQITGGNTRNRFAISTQGGVGLVTLALPL 819
Query: 547 DRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV-SGSYNIFVQEEE--GNVSV 603
D + + + L L A+D L + I++ D N + PV S Y++ V E+ G+ V
Sbjct: 820 DYKQERYFKLVLTASDRA-LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV 878
Query: 604 TIQAHDNDEPGTNNSRLLFNL---LPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGR 660
I A D+D N+R+ + L LP F +D D+G + PLD E +
Sbjct: 879 VISASDDDV--GENARITYLLEDNLP-----QFRIDADSGAITLQAPLDYED-----QVT 926
Query: 661 IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAW 719
L + D G P V + V D+NDN P F S Y V E+ P V + A
Sbjct: 927 YTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISAT 986
Query: 720 DADQTEANNRISFSLSG--SGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT 777
D D AN R+ ++ G F I G +R LD E V+ LT
Sbjct: 987 DRD-AHANGRVQYTFQNGEDGDGDFTIEP-------TSGIVRTVR--RLDREAVSVYELT 1036
Query: 778 VSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
A + T V + V V+DVNDN P +RV EN VA + A D D
Sbjct: 1037 AYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFE-VRVKENSIVGSVVAQITAVDPD 1095
Query: 838 TSAQLEI 844
I
Sbjct: 1096 EGPNAHI 1102
Score = 191 bits (486), Expect = 3e-48
Identities = 203/732 (27%), Positives = 332/732 (45%), Gaps = 98/732 (13%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGM-SGPNAYFFAVTPKTGE 78
AP+F + ED+ + A D+D D + Y + SG + FA+ TGE
Sbjct: 542 APQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE 601
Query: 79 VKLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSIN 134
+++ + LD+E + + I D P + V D ND+ P+F +T F S+
Sbjct: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSY 193
E P+G V + AVD D G + YS+ V P T F I A G + ++G L
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP-----FVINSATGWVSVSGPLDR 716
Query: 194 NNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAED 253
+ ++ ++A D H + + S V +++V+D D P+F + Y + ED
Sbjct: 717 ESVEHYF-FGVEARD-----HGSPPLSASASV--TVTVLDVNDNRPEFTMKEYHLRLNED 768
Query: 254 AAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI---GADGVIRVNGSLDREQLLE 310
AA GTSV++V AVD D N + Y I+ F I G G++ + LD +Q
Sbjct: 769 AAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQ--- 823
Query: 311 ADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
+ +L +TA++ L+ + +V + + D N H+P F +
Sbjct: 824 -ERYFKLVLTASDRALHDH-------CYVHINITDANTHRPVFQS--------------A 861
Query: 371 NFTGYVDEHASPRIPIDDLTMVV--YDPDKGSNG--TFLLSLGGPDAEAFSVSPERAAGS 426
+++ V+E P+ +V+ D D G N T+LL P F + + A
Sbjct: 862 HYSVSVNEDR----PMGSTIVVISASDDDVGENARITYLLEDNLPQ---FRIDADSGA-- 912
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + A +DYE Q + + A D+ + Q V + + D+ND+ P F S Y
Sbjct: 913 ------ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHY 966
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGAD-LFQVDPVSGTV-TVRNG 543
V E + + V I ATD D A G++ Y+ G D F ++P SG V TVR
Sbjct: 967 TGLVSEDAPPFTSVL-QISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR- 1024
Query: 544 ELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVV-SGSYNIFVQEEE-- 598
LDRE+ +VY LT A D G L + ++Q+ + D+NDNAPV + + + V+E
Sbjct: 1025 --LDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
Query: 599 GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
G+V I A D DE N+ +++ ++ G F +D +G L L LD EA
Sbjct: 1083 GSVVAQITAVDPDE--GPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA------ 1134
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQ-----SSYNFTVKEEDPGVLV 713
R ++V P++ ++ V + + D NDN P+ N ++Y + P ++
Sbjct: 1135 -RQEYVIVVQATSAPLV-SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGII 1192
Query: 714 GVVKAWDADQTE 725
G + A+D D ++
Sbjct: 1193 GRIPAYDPDVSD 1204
Score = 145 bits (365), Expect = 3e-34
Identities = 159/517 (30%), Positives = 239/517 (46%), Gaps = 59/517 (11%)
Query: 471 RDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSL---LPGNGAD 527
R N H P FPQ Y VPE+ A G+ V + A DPD G G++ YSL + +
Sbjct: 317 RAANRH-PQFPQYNYQTLVPENEAAGTAVLRVV-AQDPDAGEAGRLVYSLAALMNSRSLE 374
Query: 528 LFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPV 585
LF +DP SG + R LDRES +YL + A D G+ LS++T + + + D ND++PV
Sbjct: 375 LFSIDPQSGLI--RTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV 432
Query: 586 VS-GSYNIFVQE--EEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHN---FSLDPDT 639
Y ++E EEG + ++A D D P N R F P + F +DP +
Sbjct: 433 FEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRS 492
Query: 640 GLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV--LGTKVNVTITVEDINDNLPIFNQ 697
GL+ G +DRE ++ L V SD G+ V V ITV D NDN P F++
Sbjct: 493 GLISTSGRVDREHMES-----YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE 547
Query: 698 SSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAE 755
Y V+E+ P +V V A D D+ +AN + +++ SG+ +F I L
Sbjct: 548 KRYVAQVREDVRPHTVVLRVTATDRDK-DANGLVHYNIISGNSRGHFAIDSLT------- 599
Query: 756 GYLRLPPDVSLDYETQPVFNLTVSAENPD--PQGGETIVDVCVNVKDVNDNPPTLDVASL 813
G +++ LD+E + + L + A++ P T + + V D+ND+ P V++
Sbjct: 600 GEIQVV--APLDFEAEREYALRIRAQDAGRPPLSNNTGL-ASIQVVDINDHIPIF-VSTP 655
Query: 814 RGIRVAENGSQHGQVAVVVASDVD--TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAAN 871
+ V EN V + A D D +A+LE L + V + GW SV
Sbjct: 656 FQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSAT--GWVSV--- 710
Query: 872 GSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPE 931
S +D E+ + V A D + P S + S+ +T+ DVNDN P F +
Sbjct: 711 -------SGPLDRESVEHYFFGVEARDHGSPP----LSASASVTVTVLDVNDNRPEFTMK 759
Query: 932 NKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
+ + + E V SV A D D+ N I + I
Sbjct: 760 -EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQI 793
Score = 141 bits (355), Expect = 5e-33
Identities = 162/553 (29%), Positives = 239/553 (43%), Gaps = 68/553 (12%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNAYF-FAVTPK--TGEV 79
P+F + L ED VG + A D+D N ++Y ++G N FA++ + G V
Sbjct: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLV 813
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPV 139
LA LDY+ FK+ ++ SD + + + + D N + PVFQ+ +S S+NE P+
Sbjct: 814 TLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPM 873
Query: 140 GSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYNNKSA 198
GS + + A D D+G + Y +E +P FRI A +G+I L L Y ++
Sbjct: 874 GSTIVVISASDDDVGENARITYLLEDNLPQ-------FRIDADSGAITLQAPLDYEDQ-V 925
Query: 199 FYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
Y L + A D G Q + ++ + V D D PQFV Y+ V+EDA T
Sbjct: 926 TYTLAITARDNG-------IPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFT 978
Query: 259 SVLTVEAVDGDKGINDPVIYSI-SYSTRPGWFDI-GADGVIRVNGSLDREQLLEADEEVQ 316
SVL + A D D N V Y+ + G F I G++R LDRE +
Sbjct: 979 SVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAV------SV 1032
Query: 317 LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYV 376
++TA + VSI V V DVND+ P F EE +V V
Sbjct: 1033 YELTAYAVDRGVPPLRTPVSI--QVMVQDVNDNAP----------VFPAEEFEVR----V 1076
Query: 377 DEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRV 435
E++ + +T V DPD+G N + + G E F + +A +
Sbjct: 1077 KENSIVGSVVAQITAV--DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALID----- 1129
Query: 436 SALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR--DINDHRPTFP--QSLYVLTVPE 491
+DYE + + V AT + V+ T+H+R D ND+ P Q L+ V
Sbjct: 1130 ---LDYEARQEYVIVVQATSAP----LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSN 1182
Query: 492 HSAT-GSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRES 550
S T S + I A DPD + YS GN L V+ SG +R LD
Sbjct: 1183 RSDTFPSGIIGRIPAYDPDVS--DHLFYSFERGNELQLLVVNQTSG--ELRLSRKLDNNR 1238
Query: 551 QAVYYLTLQATDG 563
V + + TDG
Sbjct: 1239 PLVASMLVTVTDG 1251
Score = 33.5 bits (75), Expect = 1.4
Identities = 25/79 (31%), Positives = 34/79 (43%), Gaps = 10/79 (12%)
Query: 1221 PMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHRPPHTPPEPDPEPL 1280
P+ P + L + L PS LDS+S +S NS+E + P P PL
Sbjct: 3171 PLPLSPQRQLSRDPLLPSRPLDSLSRSS----------NSREQLDQVPSRHPSREALGPL 3220
Query: 1281 SVVLLGRQAGASGQLEGPS 1299
+L R+ SG GPS
Sbjct: 3221 PQLLRAREDSVSGPSHGPS 3239
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 214 bits (544), Expect = 6e-55
Identities = 258/974 (26%), Positives = 414/974 (42%), Gaps = 121/974 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD----NDPLTYGMSG--PNAYFFAVTPKT 76
+P F + + + E++P+G + A+D D N + Y + P F + P
Sbjct: 1052 SPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
Query: 77 GEVKLASALDYETLYTFKVTISVSDPYIQVQREML------VIVEDRNDNAPVFQNTAFS 130
G + S LD E++ T +T++ SD + V L +++ D ND+ P F + +
Sbjct: 1112 GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-N 1170
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNG 189
+ E + VGS+V + A D D G G V YSI +G+ F + ++G +
Sbjct: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSI-----LSGNENMTFMLDESSGLLTTTC 1225
Query: 190 SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSAS 249
L Y K+ + L + A D G T S L+++V+D D P F + Y AS
Sbjct: 1226 PLDYEMKTQ-HILTVLALDDG-------TPALSSSQTLTVTVLDVNDEAPVFKQHLYEAS 1277
Query: 250 VAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQL 308
V E+ G V VEA+D D G+N + + I F+I +D G + LDR
Sbjct: 1278 VKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDR--- 1334
Query: 309 LEADEEVQLQVTATETHLNIYGQEAKVSIWVTV--RVMDVNDHKPEFYNCSLPACTFTPE 366
E E L+V + G +S T+ V D NDH PEF S +
Sbjct: 1335 -EIQEVFTLRVLVRD------GGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS-LGGPDAEAFSVSPERAAG 425
E +V + T++ D D G+N + G E F+++ +G
Sbjct: 1388 EPEVVY-----------------TVLASDMDAGNNRAVEYHIIDGNTDECFTIN--EMSG 1428
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQSL 484
S + +D E+ + + ++ +D SV + + + D NDH P+FP
Sbjct: 1429 ELS------TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLY 1482
Query: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544
Y +V E + G+VV + A D D G GQ Y L + F +DP+SGT+ N
Sbjct: 1483 YQSSVREDAEVGTVVL-VLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSN-- 1538
Query: 545 LLDRESQAVYYLTLQATD---GGNLSSSTTLQIHLLDINDNAPVV-SGSYNIFVQEEEGN 600
LDRE+++ + + A D G+ S++ +++++ D+NDN PV+ +++F+ E
Sbjct: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPT 1598
Query: 601 VSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGR 660
T+ +D N ++F+ FS+D TG ++ E
Sbjct: 1599 NQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFP------ 1650
Query: 661 IVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAW 719
I L + V+D G P T + I +E D F+ Y V E + G + VKA+
Sbjct: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAF 1709
Query: 720 DADQTEANNRIS-FSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTV 778
D + + + S FS + G VL G L + LD+E + L V
Sbjct: 1710 APDSIQDSMKYSIFSGNEDG---------VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV 1760
Query: 779 SAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDT 838
AE+ G V V ++D NDN P + S+ V+E+ + V V A+D+D+
Sbjct: 1761 LAES---SGHRAYCKVAVLIQDENDNSPCFE-QSIYQASVSESQLYNAHVIQVFATDLDS 1816
Query: 839 --SAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRA 896
+ +E +++ +A F + A V I +DYE +L+V+
Sbjct: 1817 GLNGLIEYSILSGNQEEA-----------FQIDALSGV-ITTKAILDYELTSSYSLIVQ- 1863
Query: 897 CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDD 956
ATD G SN + + + D+NDNAP FLP V I E LP V V D
Sbjct: 1864 ---ATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA--VEITEDSLPGVIVTHVSVHDV 1918
Query: 957 DSGNNGVILFSILR 970
D N +FS +
Sbjct: 1919 DL--NSAFIFSFAK 1930
Score = 206 bits (523), Expect = 2e-52
Identities = 216/796 (27%), Positives = 356/796 (44%), Gaps = 88/796 (11%)
Query: 37 EDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYETLYT 92
E PV + A+D D N +TY +S ++ F + GE++ + L Y+ +
Sbjct: 854 EGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS 913
Query: 93 FKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149
+++++ +D P +Q Q + + V + + I E L ++ + +
Sbjct: 914 YRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSS 973
Query: 150 DK-DMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKAC 207
D G + +SI D + F I + G + L+ L Y S Y +
Sbjct: 974 DHLQQHYNGKLHFSIV-----ADDKDGHFEIDSSTGDLFLSKELDYETTS-HYLFRVITT 1027
Query: 208 DLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVD 267
D ++ + S VFLSI V DQ D P F E SV E+ GT V A D
Sbjct: 1028 D------HSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD 1081
Query: 268 GDKG-INDPVIYSISYSTRPG---WFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATE 323
D +N + Y I S PG + + G + LDRE + V L VTA++
Sbjct: 1082 DDGSFLNSRIQYYIE-SHNPGTNPFLIHPSFGTLVTVSRLDRESI----PTVILTVTASD 1136
Query: 324 THLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPR 383
+N+ + + S+ + ++DVNDH P F + + H
Sbjct: 1137 QAVNVTDRRLR-SLTAQIVILDVNDHNP-------------------TFISFPNAHVKED 1176
Query: 384 IPIDDLT--MVVYDPDKGSNGTFLLS-LGGPDAEAFSVSPERAAGSASVQVLVRVSALVD 440
+ + L + +DPD+G NG S L G + F + + ++G L+ + +D
Sbjct: 1177 VTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFML--DESSG------LLTTTCPLD 1228
Query: 441 YERQTAMAVQVVATDSVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVV 499
YE +T + V+A D + S + +T+ + D+ND P F Q LY +V E+ G V
Sbjct: 1229 YEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFV 1288
Query: 500 TDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQ 559
T + A D D+G ++ + ++PG +LF+++ +G V +LDRE Q V+ L +
Sbjct: 1289 T-RVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT--ILDREIQEVFTLRVL 1345
Query: 560 ATDGG--NLSSSTTLQIHLLDINDNAP-VVSGSYNIFVQE-EEGNVSVTIQAHDNDEPGT 615
DGG +LSS+TT+ + D ND+AP + SY+I V E +E V T+ A D D
Sbjct: 1346 VRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMD--AG 1403
Query: 616 NNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL 675
NN + ++++ G F+++ +G L LDRE I L +L SD G+P
Sbjct: 1404 NNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQI-----SNFTLVILCSDLGDPPR 1458
Query: 676 GTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSL 734
+ +++ + V D ND+ P F Y +V+E+ + G +V V+ A D D+ N + + L
Sbjct: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDE-GLNGQTEYFL 1517
Query: 735 SGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGG-ETIVD 793
+ + F I + G L+ +LD E + + A + QG T V
Sbjct: 1518 TDEASGAFTIDPM-------SGTLK--TSNTLDREARSQHTFSAVARDCSIQGSRSTTVI 1568
Query: 794 VCVNVKDVNDNPPTLD 809
+ V V DVNDN P L+
Sbjct: 1569 IKVYVTDVNDNDPVLE 1584
Score = 203 bits (516), Expect = 1e-51
Identities = 273/1060 (25%), Positives = 456/1060 (43%), Gaps = 163/1060 (15%)
Query: 27 LANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMS-GPNAYFFAVTPKTGEVKLASAL 85
L+ MT ++ + P+G Q + PL Y + ++ F + P TG + L
Sbjct: 598 LSPMTQMLQTQAHPLGPQ--------RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQF 649
Query: 86 DYETLYTFKVTISV---SDPYIQ-VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGS 141
DYE+ T+ + D ++Q V ++V V D NDN+P F + + E+
Sbjct: 650 DYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG 709
Query: 142 VVFSVLAVDKDMGSAGMVVYSIE------KVIPSTGDSEHLFRIL-ANGSIVLNGS---L 191
V+ + A+D D G G ++Y + K+ P+TG + ++ I A+G+ +G+
Sbjct: 710 VIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAF 769
Query: 192 SYNNKSAFYQLELKACDLGG-------------MYHNTFTI----------QCSLPVFLS 228
S + AF L+ C+LG H+ T+ ++ V++S
Sbjct: 770 SSDELQAFV-LKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 828
Query: 229 ISVV-DQPDLDPQFV--REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTR 285
++ + D PQ + +E + V E V TV A D D+G N V YS+S
Sbjct: 829 VTDINDNRPFFPQCLPGKELH-VKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDS 887
Query: 286 PGWFDIGADGVIRVNGSLDREQLLEAD--EEVQLQVTATETHLNIYGQEAKVSIWVTVRV 343
F I A+ NG + +L D ++ V AT+ + +A V+I V
Sbjct: 888 SDHFKIDAN-----NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLS 942
Query: 344 MDVNDHKPEFYNCSLPACTFTPEEAQ--VNFTGYVDEHASPRIPIDDLTMVVYDPDKGSN 401
+ +P P + + + ++ +H + ++ ++V D D
Sbjct: 943 KGRAIMSQNIRHLIIPE-NLKPTKIMSLIKSSDHLQQHYNGKL---HFSIVADDKD---- 994
Query: 402 GTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF 461
G F + D + +S +DYE + +V+ TD S+N
Sbjct: 995 GHFEIDSSTGD--------------------LFLSKELDYETTSHYLFRVITTDH-SKNL 1033
Query: 462 SVA---MVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITY 518
S++ ++I + D NDH P+F L V++V E+ G++V D + +I Y
Sbjct: 1034 SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY 1093
Query: 519 SLLPGN-GADLFQVDPVSGT-VTVRNGELLDRESQAVYYLTLQATDGG-NLSS----STT 571
+ N G + F + P GT VTV LDRES LT+ A+D N++ S T
Sbjct: 1094 YIESHNPGTNPFLIHPSFGTLVTVSR---LDRESIPTVILTVTASDQAVNVTDRRLRSLT 1150
Query: 572 LQIHLLDINDNAPVVSGSYNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPY 629
QI +LD+ND+ P N V+E+ G++ I AHD DE N ++ +++L G
Sbjct: 1151 AQIVILDVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEG--RNGKVTYSILSGNE 1208
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIN 689
+ F LD +GLL PLD E ++ + +LTVL D G P L + +T+TV D+N
Sbjct: 1209 NMTFMLDESSGLLTTTCPLDYE-----MKTQHILTVLALDDGTPALSSSQTLTVTVLDVN 1263
Query: 690 DNLPIFNQSSYNFTVKE-EDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
D P+F Q Y +VKE ++PG V V+A D D + N+++ F + GA++ +
Sbjct: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD-SGVNSKLQFEIM-PGASFELFE--- 1318
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
+ + E + LD E Q VF L V + + + V+D ND+ P
Sbjct: 1319 INSDTGE----VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEF 1374
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
V+S I V EN + V V+ASD+D ++ I D C+ +
Sbjct: 1375 IVSSY-DIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHII---DGNTDE---CFTINEM 1426
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ ++ ++A+D E TLV+ DL P S+ L + + D ND++P F
Sbjct: 1427 SGE----LSTTRALDREQISNFTLVILCSDLGDPP----RSSVIHLQVRVLDANDHSPSF 1478
Query: 929 LPENKTFVIIPELVLPNREVASV----RARDDDSGNNGVILFSILRVDFISKDGATIPFQ 984
+ V + EV +V A D D G NG + ++ D A+
Sbjct: 1479 -----PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNG-------QTEYFLTDEAS---- 1522
Query: 985 GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARD 1024
G F+I D +G+++ +LD + + + ARD
Sbjct: 1523 GAFTI------DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
Score = 198 bits (504), Expect = 2e-50
Identities = 286/1132 (25%), Positives = 458/1132 (40%), Gaps = 225/1132 (19%)
Query: 37 EDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF--------FAVTPKTGEVKLASALDYE 88
ED VG L A D+D G++G YF F + P +G +K ++ LD E
Sbjct: 1489 EDAEVGTVVLVLSAVDKDE-----GLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDRE 1543
Query: 89 TLYTFKVTISVSDPYIQVQREMLVIVE----DRNDNAPVFQNTAFSTSI------NETL- 137
+ D IQ R VI++ D NDN PV + F + N+T
Sbjct: 1544 ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTV 1603
Query: 138 ----------PVGSVVFS------VLAVDKDMG--------------------------- 154
P G+VVFS + ++DK G
Sbjct: 1604 IVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIP 1663
Query: 155 ---SAGMVVYSIEKVIPSTGDSEHLFRIL------ANGSIV---------LNGSLSYNNK 196
+ G++V +E S HL++ L A SIV + S+ Y+
Sbjct: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIF 1723
Query: 197 SAFYQLELKACDLGGMY------HNTFTIQCSLPVFL-------------SISVVDQPDL 237
S L C G F ++ + + + ++ + D+ D
Sbjct: 1724 SGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDN 1783
Query: 238 DPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGV 296
P F + Y ASV+E V+ V A D D G+N + YSI + F I A GV
Sbjct: 1784 SPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGV 1843
Query: 297 IRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNC 356
I LD E L V AT+ + + + VT D+ND+ P
Sbjct: 1844 ITTKAILD----YELTSSYSLIVQATDKGMPRLSNTTVIKVQVT----DINDNAP----- 1890
Query: 357 SLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAF 416
F P EA + E + P + + ++ V+D D S F + F
Sbjct: 1891 -----AFLPSEAVE-----ITEDSLPGVIVTHVS--VHDVDLNSAFIFSFAKESNPGTKF 1938
Query: 417 SVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDH 476
++ + V VLV+ +D+E T + + +DSV +++ + + + D+ND+
Sbjct: 1939 AIDQ-----NTGVVVLVKT---LDFEEMTEYELLIQISDSV--HYTEGALVVRVLDVNDN 1988
Query: 477 RPTFPQSLYVLTVPEHSATG-SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVS 535
P F Q Y +TVPE G SV+T + ATD ++ I+Y +L + + F +DP +
Sbjct: 1989 PPVFSQDFYQVTVPESIPVGYSVLT--LSATDLESNE--NISYRIL--SSSKEFSIDPKN 2042
Query: 536 GTV-TVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVS-GSYN 591
GT+ T+ LLD S + + +A+DGGN L + T ++I + D+N+ AP + SYN
Sbjct: 2043 GTIFTISPVLLLDTISTTQFLV--EASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
Query: 592 IFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDP----------DT 639
+ + E+ G+ VT D+D N+ + ++++ G +NF ++
Sbjct: 2101 LSLSEDALVGSTLVTFSNIDHDWT-RENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQV 2159
Query: 640 GLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSS 699
G L L LDREA L +L SD G P L + ++I V D+NDN P F+ S
Sbjct: 2160 GYLVLLHSLDREA-----SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS 2214
Query: 700 YNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL 758
Y+ VKE P G + VV A D D I +SG+ +F + YL
Sbjct: 2215 YHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLE-----ENTGVLYL 2269
Query: 759 RLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRV 818
P LDYE F LTV A + + + V V V+V D ND+ P +S I V
Sbjct: 2270 IKP----LDYEKMTKFTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCI-V 2323
Query: 819 AENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVY--- 875
EN + + A D D E+ + S C+ ++ + ++
Sbjct: 2324 PENLPISSTICSINALDFDAGPYGELTY----------SIVSPCFLTHGMSYDHDLFLID 2373
Query: 876 -----INQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLI--TIEDVNDNAPYF 928
I+ + +DYE + L V+A D SL++ IE +++ P F
Sbjct: 2374 PLTGDIHAKQILDYENGNKYCLTVQAKDKG--------DATASLVVWVDIEGIDEFEPIF 2425
Query: 929 LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFS 988
+++ F +PE + + V A D D+G +GVIL+S+ G + PF FS
Sbjct: 2426 T-QDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL---------GTSSPF---FS 2472
Query: 989 IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNL 1040
+ + +++ P+ + T ++ + A S F T +N+
Sbjct: 2473 V-NKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNV 2523
Score = 186 bits (473), Expect = 1e-46
Identities = 282/1080 (26%), Positives = 440/1080 (40%), Gaps = 174/1080 (16%)
Query: 35 LPEDLPVGAQAFWLVAEDQDN--DPLTYGMS-GPNAYFFAVTPKTGEVKLASALDYETLY 91
+PED P+G + A + N +P+ Y +S G F++ P+ G ++ LD+ET
Sbjct: 390 VPEDSPIGT----VKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 445
Query: 92 TFKVTISV---SDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLA 148
+T+ S P E+ + V D NDN P F T+ I++T P G+ ++ A
Sbjct: 446 VVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
Query: 149 VDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACD 208
D+D G G++ YSI P + A G + LNGSL + L L+A D
Sbjct: 505 EDRDSGRNGLIRYSIASPQPGVFAIDR-----ALGVLFLNGSLGAGEQREL-TLTLRAED 558
Query: 209 LGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREF--YSASVAEDAAKGTSVLTVEAV 266
G + + + V+++ + P + E Y V+E + T +L +A
Sbjct: 559 QG--------VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
Query: 267 D-GDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQLQVTATET 324
G + P+ YS+ S F I G I + D E + V +
Sbjct: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED-- 668
Query: 325 HLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRI 384
G VS V VRV D ND+ P F + V F V+E P+
Sbjct: 669 -----GFLQNVSTTVIVRVWDENDNSPTFLH-------------DVLFLK-VEESPVPQG 709
Query: 385 PIDDLTMVVYDPDKGSNGT---FLLSLG---------GP-----------DAEAFSVSPE 421
I +T + D D G NG FLLS G GP A AFS +
Sbjct: 710 VIGKITAI--DMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS-GTD 766
Query: 422 RAAGSASVQVLVRVSAL-------------VDYERQTAMAVQVVATDSVSQNFSVAM-VT 467
A S +Q V S +D E + + V+ TD S + M V
Sbjct: 767 FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 826
Query: 468 IHLRDINDHRPTFPQSL----YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPG 523
+ + DIND+RP FPQ L + V E +VT ++ A DPD G ++TYS+
Sbjct: 827 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT-TVFAKDPDEGNNAEVTYSVSSE 885
Query: 524 NGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDIND 581
+ +D F++D +G +R +L + + Y +++ ATD G L + I ++ ++
Sbjct: 886 DSSDHFKIDANNG--EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSK 943
Query: 582 NAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPD 638
++S + + E + I++ D+ + N +L F+++ +F +D
Sbjct: 944 GRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQ-HYNGKLHFSIVADDKDGHFEIDSS 1002
Query: 639 TGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQ 697
TG L LD E + V+ +D + + L + V ++I VED ND+ P F
Sbjct: 1003 TGDLFLSKELDYET-----TSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD 1057
Query: 698 SSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLS--GSGANYFMIRGLVLGAGWA 754
+V+E P G LV V A D D + N+RI + + G N F+I
Sbjct: 1058 ELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIH--------- 1108
Query: 755 EGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGE---TIVDVCVNVKDVNDNPPTLDVA 811
+ L LD E+ P LTV+A + + + + + DVND+ PT
Sbjct: 1109 PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--I 1166
Query: 812 SLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAAN 871
S V E+ + V + A D D G + + S N
Sbjct: 1167 SFPNAHVKEDVTVGSLVHHITAHDPDEGRN-----------------GKVTYSILSGNEN 1209
Query: 872 GSVYINQSKA-------IDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDN 924
+ +++S +DYE L V LA D G A S++ +L +T+ DVND
Sbjct: 1210 MTFMLDESSGLLTTTCPLDYEMKTQHILTV----LALDDGTPALSSSQTLTVTVLDVNDE 1265
Query: 925 APYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQ 984
AP F ++ + E P V V A D DSG N + F I+ GA+
Sbjct: 1266 APVF-KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM-------PGAS---- 1313
Query: 985 GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
F +F E + G + T LD +Q + + V RD P L +TTT+ L TV+
Sbjct: 1314 --FELF---EINSDTGEVVTTTILDREIQEVFTLRVLVRDGGF--PSLSSTTTI-LCTVE 1365
Score = 178 bits (452), Expect = 3e-44
Identities = 253/1059 (23%), Positives = 424/1059 (40%), Gaps = 125/1059 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYG-MSGPNAYFFAVTPKTGE 78
AP F ++ + E+ G + A D+D N L + M G + F + TGE
Sbjct: 1266 APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGE 1325
Query: 79 VKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
V + LD E F + + V D P + +L VED ND+AP F +++ + E
Sbjct: 1326 VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE 1385
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYN 194
VV++VLA D D G+ V Y I G+++ F I +G + +L
Sbjct: 1386 NQEP-EVVYTVLASDMDAGNNRAVEYHI-----IDGNTDECFTINEMSGELSTTRALDRE 1439
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
S F L + DLG ++ + L + V+D D P F +Y +SV EDA
Sbjct: 1440 QISNF-TLVILCSDLGDPPRSSV-------IHLQVRVLDANDHSPSFPTLYYQSSVREDA 1491
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEE 314
GT VL + AVD D+G+N Y ++ GA + ++G+L L+ +
Sbjct: 1492 EVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS------GAFTIDPMSGTLKTSNTLDREAR 1545
Query: 315 VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTG 374
Q +A +I G + ++ + V V DVND+ P V
Sbjct: 1546 SQHTFSAVARDCSIQGSRS-TTVIIKVYVTDVNDNDP------------------VLEQN 1586
Query: 375 YVDEHASPRIPIDDLTMVVY--DPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVL 432
D SP P + T++V D D G NGT + S + FS+ + +Q
Sbjct: 1587 PFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS-MFSIDKY----TGEIQFQ 1641
Query: 433 VRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
S+ + +Q+ TD + + ++ IH+ D + +F LY V E
Sbjct: 1642 QNPSS-----EYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHLYKGLVTE 1695
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
+ G+ + ++ A PD+ + YS+ GN + + SG +TV+ + LD E +
Sbjct: 1696 NCEAGTSIV-TVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
Query: 552 AVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVSVTIQAHDN 610
L + A G+ + + + + D NDN+P S Y V E + + IQ
Sbjct: 1754 NEVQLIVLAESSGH-RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFAT 1812
Query: 611 DEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDC 670
D N + +++L G F +D +G++ LD E L L V +D
Sbjct: 1813 DLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYE-----LTSSYSLIVQATDK 1867
Query: 671 GEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRI 730
G P L + + V DINDN P F S ++ PGV+V V D D A
Sbjct: 1868 GMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSA-FIF 1926
Query: 731 SFSLSGSGANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQG 787
SF+ + F I G+V+ +LD+E + L + +
Sbjct: 1927 SFAKESNPGTKFAIDQNTGVVVLV------------KTLDFEEMTEYELLIQISDSVHYT 1974
Query: 788 GETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLV 847
+V V V DVNDNPP + V E+ V + A+D++++ + +++
Sbjct: 1975 EGALV---VRVLDVNDNPPVFS-QDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL 2030
Query: 848 NILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQA 907
+ +K FS+ S + + +V A D +P +A
Sbjct: 2031 S--SSKE-----------FSIDPKNGTIFTISPVLLLDTISTTQFLVEASD-GGNPDLRA 2076
Query: 908 YSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFS 967
+ + I IED+N+ AP F ++ + + ++ + V D + N + +S
Sbjct: 2077 LT---LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYS 2133
Query: 968 ILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPS 1027
I+ + F F S G + + SLD ++++ + A D S
Sbjct: 2134 II------SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD--S 2185
Query: 1028 LGPFLEATTTLNLFTVD----------QSYRSRLQFSTP 1056
P L +T +++ +D SY + ++ STP
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224
Score = 155 bits (392), Expect = 2e-37
Identities = 180/696 (25%), Positives = 299/696 (42%), Gaps = 88/696 (12%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGM---SGPNAYFFAVTPKTGE 78
AP FL + I + LP G + D D N + S P F A+ TG
Sbjct: 1889 APAFLPSEAVEITEDSLP-GVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF-AIDQNTGV 1946
Query: 79 VKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLP 138
V L LD+E + +++ I +SD + ++V V D NDN PVF + ++ E++P
Sbjct: 1947 VVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIP 2006
Query: 139 VGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSA 198
VG V ++ A D+ S + Y I S+ NG+I + + +
Sbjct: 2007 VGYSVLTLSAT--DLESNENISYRI------LSSSKEFSIDPKNGTIFTISPVLLLDTIS 2058
Query: 199 FYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
Q ++A D G T+ + I + D + P+F + Y+ S++EDA G+
Sbjct: 2059 TTQFLVEASDGGNPDLRALTL-------VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGS 2111
Query: 259 SVLTVEAVDGD-KGINDPVIYSISYSTRPGWFDIGAD-----------GVIRVNGSLDRE 306
+++T +D D N V YSI F + G + + SLDR
Sbjct: 2112 TLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR- 2170
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
EA +L + A+++ A +SI +V+DVND+ P F + S
Sbjct: 2171 ---EASASHELVILASDSGCPPLSSTAVISI----QVLDVNDNPPNFSSLS--------- 2214
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVV--YDPDKGSNGTFLLSLGGPDAEAFSVSPERAA 424
H P+ VV D D GS+ + ++ + + E
Sbjct: 2215 ---------YHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTG 2265
Query: 425 GSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSL 484
VL + L DYE+ T + V A+D+ ++FS A+V + + D NDH P F S
Sbjct: 2266 ------VLYLIKPL-DYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSS 2318
Query: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLP--------GNGADLFQVDPVSG 536
+ VPE+ S + SI+A D D G +G++TYS++ DLF +DP++G
Sbjct: 2319 FSCIVPENLPISSTIC-SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTG 2377
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQE 596
+ + ++LD E+ Y LT+QA D G+ ++S + + + I++ P+ + F
Sbjct: 2378 DIHAK--QILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP 2435
Query: 597 EEGNVSVTI-QAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTG---LLRNLGPLDREA 652
E+ I + +D + +L++L G S FS++ G L+R L PL +
Sbjct: 2436 EKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL-PLIKSQ 2492
Query: 653 I--DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVE 686
+ + LE +I+ SD VNV+ + E
Sbjct: 2493 LNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSE 2528
Score = 154 bits (388), Expect = 7e-37
Identities = 237/1013 (23%), Positives = 410/1013 (40%), Gaps = 144/1013 (14%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
P FL + + + P G + AED+D N + Y ++ P FA+ G +
Sbjct: 478 PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLF 537
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREMLV--IVEDRNDNAP--VFQNTAFSTSINET 136
L +L +T+ D + Q +LV +V ++ +++P F++ + ++E+
Sbjct: 538 LNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSES 597
Query: 137 L-PVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILA-NGSIVLNGSLSYN 194
L P+ ++ + +A + YS+E + S +F I G I L Y
Sbjct: 598 LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA-----MFGIRPYTGWIYLRRQFDYE 652
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
+ + G N T + + V D+ D P F+ + V E
Sbjct: 653 STQTYNFRVFAWIPEDGFLQNVSTT-------VIVRVWDENDNSPTFLHDVLFLKVEESP 705
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSI-----SYSTRPGWFDIG-------ADGVIRVNG- 301
+ + A+D D G N ++Y + + P G ADG +G
Sbjct: 706 VPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGT 765
Query: 302 ----SLDREQ--------------------LLEADEEVQLQVTATETHLNIYGQEAKVSI 337
S D Q L+ + ++T T + A +++
Sbjct: 766 DFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 825
Query: 338 WVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVY--D 395
+V+ V D+ND++P F C LP +E V P++ L V+ D
Sbjct: 826 YVS--VTDINDNRPFFPQC-LPG-----KELHVK--------VLEGQPVNMLVTTVFAKD 869
Query: 396 PDKGSNGTFLLSLGGPD-AEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVAT 454
PD+G+N S+ D ++ F + +R + ++ Y+ + + + V+AT
Sbjct: 870 PDEGNNAEVTYSVSSEDSSDHFKIDANNGE--------IRTTTILSYDYRPSYRMSVIAT 921
Query: 455 D-SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEH---SATGSVVTDSIHATDPDT 510
D V A+V I + ++ R Q++ L +PE+ + S++ S H
Sbjct: 922 DQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYN 981
Query: 511 GAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG---NLS 567
G++ +S++ + F++D +G + + + LD E+ + Y + TD +LS
Sbjct: 982 ---GKLHFSIVADDKDGHFEIDSSTGDLFL--SKELDYETTSHYLFRVITTDHSKNLSLS 1036
Query: 568 SSTTLQIHLLDINDNAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNNSRLLFNL 624
S+ L I + D ND++P + EE G + A D+D N+ +
Sbjct: 1037 STVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIE 1096
Query: 625 LPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK---VNV 681
P ++ F + P G L + LDRE+I ++LTV SD V + +
Sbjct: 1097 SHNPGTNPFLIHPSFGTLVTVSRLDRESIP-----TVILTVTASDQAVNVTDRRLRSLTA 1151
Query: 682 TITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFS-LSGSGA 739
I + D+ND+ P F S N VKE+ G LV + A D D+ N ++++S LSG+
Sbjct: 1152 QIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGR-NGKVTYSILSGNEN 1209
Query: 740 NYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVK 799
FM+ E L LDYE + LTV A + + + V V
Sbjct: 1210 MTFML---------DESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260
Query: 800 DVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVG 859
DVND P L V EN + V V A D D+ ++Q + A ++
Sbjct: 1261 DVNDEAPVFK-QHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE--IMPGASFEL- 1316
Query: 860 SLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIE 919
F + ++ + + +D E ++ TL V L D GF + S+ ++L T+E
Sbjct: 1317 ------FEINSDTGEVVT-TTILDREIQEVFTLRV----LVRDGGFPSLSSTTTILCTVE 1365
Query: 920 DVNDNAPYFLPENKTFVIIPELVLPNRE---VASVRARDDDSGNNGVILFSIL 969
D ND+AP F+ + VL N+E V +V A D D+GNN + + I+
Sbjct: 1366 DENDHAPEFIVSSYDIE-----VLENQEPEVVYTVLASDMDAGNNRAVEYHII 1413
Score = 94.7 bits (234), Expect = 5e-19
Identities = 166/688 (24%), Positives = 273/688 (39%), Gaps = 100/688 (14%)
Query: 407 SLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV-AM 465
S G A + + + G + + + +S L T +++ V A D + A
Sbjct: 307 SADGEAAARYVANLAKILGEGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAVINAD 362
Query: 466 VTIH-----LRDINDHRPTFPQSLYVLTVPEHSATGSV-VTDSIHATDPDTGAWGQITYS 519
VTIH L RP + +Y VPE S G+V + +++++P I Y
Sbjct: 363 VTIHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGTVKAREPLNSSEP-------IFYR 414
Query: 520 LLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLS-SSTTLQIHLLD 578
+ G+ F + P GT+ R LD E+Q V LT+QA G + SST + I ++D
Sbjct: 415 ISSGDLGGKFSIHPRLGTIRTRKP--LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMD 472
Query: 579 INDNAPV---VSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSL 635
+NDN P S I G +A D D G N L+ + P F++
Sbjct: 473 VNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS-GRNG--LIRYSIASPQPGVFAI 529
Query: 636 DPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLP-- 693
D G+L G L + + LT+ D G + +T+ +E ++ P
Sbjct: 530 DRALGVLFLNGSLGAGE-----QRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSW 583
Query: 694 IFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAG 752
F Y V E P + +A A + + +SL S + G+ G
Sbjct: 584 TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMF--GIRPYTG 641
Query: 753 WAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETI-VDVCVNVKDVNDNPPTLDVA 811
W YLR DYE+ +N V A P+ + + V V V D NDN PT +
Sbjct: 642 WI--YLRR----QFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF-LH 694
Query: 812 SLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCT-----KAGVDVGS------ 860
+ ++V E+ G + + A D+D+ QL+ L + K + G
Sbjct: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNG--QLLYFLLSDGKFFKMNPNTGPAGTIYV 752
Query: 861 LCWGWFSVAANGS----------VYINQSKAIDYEACDLVTLVVRACD---------LAT 901
+ W + A +G+ ++ +S + +L+ V + L T
Sbjct: 753 ITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVT 812
Query: 902 DPGFQAYSNNGSLLITIEDVNDNAPYF---LPENKTFVIIPELVLPNREVASVRARDDDS 958
D G + ++ +++ D+NDN P+F LP + V + E N V +V A+D D
Sbjct: 813 DRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 872
Query: 959 GNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQV 1018
GNN + +S+ D S D I D G I+ T L + +Y++
Sbjct: 873 GNNAEVTYSVSSED--SSDHFKI--------------DANNGEIRTTTILSYDYRPSYRM 916
Query: 1019 TVQARDRPSLGPFLEATTTLNLFTVDQS 1046
+V A D+ P L+ +N+ + S
Sbjct: 917 SVIATDQGV--PPLQGQAVVNIQVIPLS 942
Score = 89.0 bits (219), Expect = 3e-17
Identities = 183/825 (22%), Positives = 306/825 (37%), Gaps = 125/825 (15%)
Query: 252 EDAAKGTSVLTVEAVDGDKGINDPVIYSI-----SYSTRPGWFDIGADGVIRVNGSLDRE 306
E+ AK V A D D G+ + YS+ SY + DG I V+ +DRE
Sbjct: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
Query: 307 Q-------LLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
+ L+EA + + ++T HL + +V V + DVND+ P
Sbjct: 128 RDPATYDLLVEAKDGDEQRMT----HLALVKGGLSAQAFVRVDLEDVNDNHP-------- 175
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSV 418
F P + + + P I + ++ D D G GT L G + F++
Sbjct: 176 --VFNPS----TYVTSISDETQPGTEI--INVLATDQDSGIYGTVAYELIPGNVSSLFTI 227
Query: 419 SPERAAGSASVQVLVRVSALVDYERQTAMAVQVVAT---DSVSQNFSVAMVTIHLRDIND 475
S V++L V+ D E ++ + + V ++ A
Sbjct: 228 DSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWF 287
Query: 476 HRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVS 535
R + L+ L V + +A+ + + + I Y LP
Sbjct: 288 MRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLP------------- 334
Query: 536 GTVTVRNGELLDRESQAVYYLTLQATDGGNLSS--STTLQIHLLDIN-DNAPVVSGSYNI 592
L L + A DGG L++ + + IH+ A Y
Sbjct: 335 ----------LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 384
Query: 593 FVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDR 650
V E+ E + T++A EP ++ + + + G FS+ P G +R PLD
Sbjct: 385 LVYEDVPEDSPIGTVKAR---EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 441
Query: 651 EAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE-EDP 709
E + +VLTV + G + V ITV D+NDN P F ++S + + P
Sbjct: 442 ET-----QPVVVLTVQ-AQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 495
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYE 769
G + + +A D D + N I +S++ F I LG + G SL
Sbjct: 496 GTALYLARAEDRD-SGRNGLIRYSIASPQPGVFAI-DRALGVLFLNG--------SLGAG 545
Query: 770 TQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVA 829
Q LT+ AE+ ++ + V ++ +P + + V+E+ S Q+
Sbjct: 546 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQML 605
Query: 830 VVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDL 889
A + + + L V S +G G +Y+ + DYE+
Sbjct: 606 QTQAHPLGPQ-----RAASPLRYSLEPSVDSAMFG--IRPYTGWIYLR--RQFDYESTQ- 655
Query: 890 VTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVA 949
T R + GF + + ++++ + D NDN+P FL + F+ + E +P +
Sbjct: 656 -TYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFL-HDVLFLKVEESPVPQGVIG 712
Query: 950 SVRARDDDSGNNGVILFSILRVDFISK-----------------DGATIPFQGVFSIFTS 992
+ A D DSG NG +L+ +L K DGA F G F+S
Sbjct: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAA-AFSGTDFAFSS 771
Query: 993 SEADVFA----------GSIQPVTSLDSTLQGTYQVTVQARDRPS 1027
E F G + +LD +G +++TV DR S
Sbjct: 772 DELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 19/124 (15%)
Query: 70 FAVTPKTGEVKLASALDYE---TLYTFKVTISVSDPY-----------IQVQREMLVIVE 115
F + P G++ ++ +D E Y V D + Q + V +E
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
Query: 116 DRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
D NDN PVF + + TSI++ G+ + +VLA D+D G G V Y ++IP G+
Sbjct: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY---ELIP--GNVSS 223
Query: 176 LFRI 179
LF I
Sbjct: 224 LFTI 227
Score = 43.1 bits (100), Expect = 0.002
Identities = 40/139 (28%), Positives = 58/139 (41%), Gaps = 5/139 (3%)
Query: 146 VLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN-GSIVLNGSLSYNNKSAFYQL-- 202
V A D D G G + YS+ S ++ FRI + G I ++ + A Y L
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSY-EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 203 ELKACDLGGMYHNTFTIQ-CSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVL 261
E K D M H S F+ + + D D P F Y S++++ GT ++
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 262 TVEAVDGDKGINDPVIYSI 280
V A D D GI V Y +
Sbjct: 198 NVLATDQDSGIYGTVAYEL 216
>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
Length = 530
Score = 213 bits (542), Expect = 1e-54
Identities = 163/471 (34%), Positives = 236/471 (50%), Gaps = 31/471 (6%)
Query: 31 TSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYET 89
T +++ ED PVG+ L+A+D DNDPL +G+SG A FFAV P TG V L LD ET
Sbjct: 38 TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
Query: 90 LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149
F V SVSD + R++ + V D NDNAP F N +S I E PVG+ +F V A
Sbjct: 98 KSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 150 DKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDL 209
D D+G+ G V+YS + S+ A G + + L Y A YQL + A D
Sbjct: 158 DPDLGAGGSVLYSFQP------PSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATD- 209
Query: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
T S L+I + D D+DP F+ YS ++ E + GT+V + A+D D
Sbjct: 210 -----QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
Query: 270 KGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNI 328
KG + Y+I F + GV+ +NG LDRE L + + L V TE + +
Sbjct: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
Query: 329 YGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDD 388
+A V+ + V+D+ND+ PEF N S + T E AQV F +P+
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEF-NSSEYSVAIT-ELAQVGFA----------LPL-F 370
Query: 389 LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMA 448
+ +V D + G N F + L G ++ F +SP G A ++ +RV+ +DYE
Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR--IRVAIPLDYETVDRYD 428
Query: 449 VQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVV 499
+ A +SV + A V I L + ND+RP F Q LY +++ E+ G+ V
Sbjct: 429 FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
Score = 126 bits (316), Expect = 2e-28
Identities = 138/475 (29%), Positives = 215/475 (45%), Gaps = 37/475 (7%)
Query: 387 DDLTMVVYDPDKGSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQV---LVRVSALVDYE 442
D ++ D GS+ T LL+ D F VS E A+ +V+ +V + +D E
Sbjct: 37 DTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRE 96
Query: 443 RQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS 502
++ V+ +D Q V I + D+ND+ PTF Y + +PE++ G+ +
Sbjct: 97 TKSEFTVEFSVSDH--QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF-I 153
Query: 503 IHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATD 562
++ATDPD GA G + YS P + F +D G VTV LD E+ Y LT+ ATD
Sbjct: 154 VNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 209
Query: 563 GGN---LSSSTTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPGTN 616
LS+ L I + D+ D P+ S NI+ G I A D D+
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
Query: 617 NSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
+ + ++ G + F+LD +G+L G LDRE +P +LTV ++ +
Sbjct: 270 G--IGYTIVSGNTNSIFALDYISGVLTLNGLLDRE--NPLYSHGFILTVKGTELNDDRTP 325
Query: 677 TKVNVTIT----VEDINDNLPIFNQSSYNFTVKE--EDPGVLVGVVKAWDADQT-EANNR 729
+ VT T V DINDN P FN S Y+ + E + L ++ D D+ N+
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
Query: 730 ISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYET--QPVFNLTVSAENPDPQG 787
L G+ +++F+I + G A+ +R+ + LDYET + F+L + PD G
Sbjct: 386 FEVYLVGNNSHHFIISPTSV-QGKAD--IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 442
Query: 788 GETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
V + + + NDN P L I + EN + V V+ S T+ L
Sbjct: 443 ---YAKVKITLINENDNRPIFS-QPLYNISLYENVTVGTSVLTVLVSPRFTAGPL 493
Score = 93.2 bits (230), Expect = 1e-18
Identities = 101/359 (28%), Positives = 165/359 (45%), Gaps = 41/359 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
AP F SV +PE+ PVG F + A D D + Y P + FFA+ G V
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIV 187
Query: 80 KLASALDYETLYTFKVTISVSDP----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
+ LDYET +++T++ +D + + +I+ D D P+F N +ST+I E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYN 194
P G+ V + A+D+D G + Y+I +G++ +F + +G + LNG L
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTI-----VSGNTNSIFALDYISGVLTLNGLLDRE 302
Query: 195 NK--SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
N S + L +K +L + ++ +I V+D D P+F YS ++ E
Sbjct: 303 NPLYSHGFILTVKGTELN---DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 253 DAAKGTSV-LTVEAVDGDK--GINDPV-IYSISYSTR-----PGWFDIGADGVIRVNGSL 303
A G ++ L ++ VD D+ G+N +Y + ++ P AD IRV L
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSL 358
D E + + + A E+ + G AKV I +++ ND++P F YN SL
Sbjct: 420 DYETV----DRYDFDLFANESVPDHVGY-AKVKI----TLINENDNRPIFSQPLYNISL 469
Score = 50.4 bits (119), Expect = 1e-05
Identities = 41/148 (27%), Positives = 75/148 (50%), Gaps = 15/148 (10%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVG-AQAFWLVAEDQD-----NDPLTYGMSGPNA 67
LV+ + N AP+F ++ SV + E VG A ++ D+D N + G N+
Sbjct: 337 LVIDINDN-APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
Query: 68 YFFAVTPKTGE------VKLASALDYETL--YTFKVTISVSDPYIQVQREMLVIVEDRND 119
+ F ++P + + +++A LDYET+ Y F + + S P ++ + + + ND
Sbjct: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455
Query: 120 NAPVFQNTAFSTSINETLPVGSVVFSVL 147
N P+F ++ S+ E + VG+ V +VL
Sbjct: 456 NRPIFSQPLYNISLYENVTVGTSVLTVL 483
Score = 39.7 bits (91), Expect = 0.019
Identities = 36/116 (31%), Positives = 46/116 (39%), Gaps = 21/116 (18%)
Query: 916 ITIEDVNDNAPYFLPENKTF-VIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFI 974
I + DVNDNAP F N+ + V IPE + V A D D G G +L+S
Sbjct: 120 IQVGDVNDNAPTF--HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS------- 170
Query: 975 SKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGP 1030
FQ F A G + + LD YQ+TV A D+ P
Sbjct: 171 --------FQPPSQFFAIDSA---RGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 210 bits (534), Expect = 8e-54
Identities = 256/1009 (25%), Positives = 433/1009 (42%), Gaps = 121/1009 (11%)
Query: 10 LLPALVVSVAANVA-PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM---SGP 65
L+P + V V+ PKF + + PEDLP G++ +V DP+ Y + + P
Sbjct: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSE-IGIVKAVAAQDPVIYSLVRGTTP 2732
Query: 66 NAY---FFAVTPKTGEVKLASALDYETLYTFKVTIS---VSDPYIQVQREMLVIVEDRND 119
+ F++ P TG +K+ +D+E+ +++ + + + + + + V D ND
Sbjct: 2733 ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
Query: 120 NAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH-LFR 178
N PVF+ + + E +PVG+ V V A+DKD G G V Y ++ G + H LF
Sbjct: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSY---RLSADPGSNVHELFA 2849
Query: 179 ILANGSIVLNGSLSYNNKSAFYQLELKACDLGGM----YHNTFTIQCSLPVFLSISVVDQ 234
I + + + +L+ + C Y + TIQ S + +S+ D+
Sbjct: 2850 IDSESGWI----------TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
Query: 235 PDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD-KGINDPVIYSISYSTRPGWF---D 290
D P+F E Y SV E++ G V T++ +D D N V I+ G F
Sbjct: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
Query: 291 IGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHK 350
+G + I +LDRE + L+VTA++ + + S+ V + V+DVND+
Sbjct: 2960 VGDEWRISSRKTLDREH----TAKYLLRVTASD-------GKFQASVTVEIFVLDVNDNS 3008
Query: 351 PEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGG 410
P+ CS Q+ +TG V E P I L + D D +N SL G
Sbjct: 3009 PQ---CS-----------QLLYTGKVHEDVFPGHFI--LKVSATDLDTDTNAQITYSLHG 3052
Query: 411 PDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHL 470
P A F + P L ++AL D ER+ + ATD ++ A +T+H+
Sbjct: 3053 PGAHEFKLDPHTGE-------LTTLTAL-DRERKDVFNLVAKATDGGGRSCQ-ADITLHV 3103
Query: 471 RDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F S + V +++ + V + A DPD GA Q+ YS LP + F
Sbjct: 3104 EDVNDNAPRFFPSHCAVAVFDNTTVKTPVA-VVFARDPDQGANAQVVYS-LPDSAEGHFS 3161
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDNAPV-V 586
+D +G +R + L QA LT++A+D G LS+ T+ + ++ + D PV +
Sbjct: 3162 IDATTG--VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL 3219
Query: 587 SGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLG 646
+ +++ V E+ + +Q PG + + ++ G F LD TG+L
Sbjct: 3220 NTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG--YRVVSGNEQGRFRLDARTGILYVNA 3277
Query: 647 PLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE 706
LD E + L++ S L V + + D+N++ P F Q Y+ V E
Sbjct: 3278 SLDFET-----SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLE 3332
Query: 707 ED-PGVLVGVVKAWDADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPDV 764
G ++ V A D D N+ I++SL G+ +F I +G L++
Sbjct: 3333 NALVGDVILTVSATDED-GPLNSDITYSLIGGNQLGHFTIHP-------KKGELQVAK-- 3382
Query: 765 SLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQ 824
+LD E ++L + A + D+ + V DVNDNPP + V EN
Sbjct: 3383 ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNY-STTVQENSPI 3441
Query: 825 HGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDY 884
+V ++ SD D+ I G F V +G ++ ++ +
Sbjct: 3442 GSKVLQLILSDPDSPENGPPYSFRITKGNNG--------SAFRVTPDG--WLVTAEGLSR 3491
Query: 885 EACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLP 944
A + L ++ A+D G S+ S+ + + + + AP LP + F+ + E
Sbjct: 3492 RAQEWYQLQIQ----ASDSGIPPLSSLTSVRVHVTEQSHYAPSALP-LEIFITVGEDEFQ 3546
Query: 945 NREVASVRARDDDSGNNGVILFSILRVDFISK-------DGATIPFQGV 986
V + A D D + +S+ + + + DG I QG+
Sbjct: 3547 GGMVGKIHATDRDP--QDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGL 3593
Score = 189 bits (480), Expect = 1e-47
Identities = 258/983 (26%), Positives = 427/983 (43%), Gaps = 119/983 (12%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVT 73
++V+V P F + V +PE++ + A + L Y + T
Sbjct: 2159 VLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTT 2218
Query: 74 P-KTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLV--IVEDRNDNAPVFQNTAFS 130
KTG + + LDYE+ T+ +D + E V +VED NDN P F ++
Sbjct: 2219 DFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYT 2278
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRIL-ANGSIVLNG 189
TSI+E LP + V +LA D+D G V Y +++ D F+I + G +
Sbjct: 2279 TSISEGLPAQTPVIQLLASDQDSGRNRDVSY---QIVEDGSDVSKFFQINGSTGEMSTVQ 2335
Query: 190 SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSAS 249
L Y + F+ ++++A D G T+ + ++V D D P+F + Y A+
Sbjct: 2336 ELDYEAQQHFH-VKVRAMDKGDPPLTGETL-------VVVNVSDINDNPPEFRQPQYEAN 2387
Query: 250 VAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLL 309
V+E A G VL V+A+D D + Y I + F I + I +L ++ L
Sbjct: 2388 VSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL- 2446
Query: 310 EADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQ 369
D L+V A++ + ++ V + + N + PEF Q
Sbjct: 2447 --DSSYNLRVGASDGVF-------RATVPVYINTTNANKYSPEF--------------QQ 2483
Query: 370 VNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDA-EAFSVSPERAAGSAS 428
+ + E+A + DL + D D G GT ++ A E FS++P A+
Sbjct: 2484 HLYEAELAENAMVGTKVIDLLAI--DKDSGPYGTIDYTIINKLASEKFSINPN--GQIAT 2539
Query: 429 VQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLT 488
+Q L R + + +A++V+A D + V I L D ND+ P F S Y ++
Sbjct: 2540 LQKLDR-----ENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGN-GADLFQVDPVSGTVTVRNGELLD 547
+ + + S V + A D D G +TYS+ P + D+ +++PV+G V V++ L+
Sbjct: 2594 IQSNVSKDSPVI-QVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKD-SLVG 2651
Query: 548 RESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEE---EGNVS 602
E+Q + + ++A DGG + +S +++ ++ + P S F E EG+
Sbjct: 2652 LENQTLDFF-IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEI 2710
Query: 603 VTIQAHDNDEPGTNNSRLLFNLLPG--PYSHN---FSLDPDTGLLRNLGPLDREAIDPAL 657
++A +P ++++L+ G P S+ FSLDPDTG+++ P+D E+
Sbjct: 2711 GIVKAVAAQDP------VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST---- 2760
Query: 658 EGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGV 715
++ +++ C + + + V+V I V D+NDN P+F Y + E P G V
Sbjct: 2761 --KLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQ 2818
Query: 716 VKAWDADQTEANNRISFSLSGS-GANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
V A D D T + ++S+ LS G+N + + +GW + LD ET +
Sbjct: 2819 VTAIDKD-TGRDGQVSYRLSADPGSNVHELFAIDSESGW------ITTLQELDCETCQTY 2871
Query: 775 NLTVSAENPDPQGGETI-----VDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVA 829
+ V A + G+TI V V++ D NDN P RG V EN VA
Sbjct: 2872 HFHVVAYD----HGQTIQLSSQALVQVSITDENDNAPRFASEEYRG-SVVENSEPGELVA 2926
Query: 830 VVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVY-INQSKAIDYEACD 888
+ D D S Q + C D G F ++ G + I+ K +D E
Sbjct: 2927 TLKTLDADISEQNR----QVTCYITEGDP----LGQFGISQVGDEWRISSRKTLDREHTA 2978
Query: 889 LVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAP---YFLPENKTFVIIPELVLPN 945
L V A+D FQA + ++ I + DVNDN+P L K + E V P
Sbjct: 2979 KYLLRV----TASDGKFQA---SVTVEIFVLDVNDNSPQCSQLLYTGK----VHEDVFPG 3027
Query: 946 REVASVRARDDDSGNNGVILFSI 968
+ V A D D+ N I +S+
Sbjct: 3028 HFILKVSATDLDTDTNAQITYSL 3050
Score = 181 bits (460), Expect = 3e-45
Identities = 242/946 (25%), Positives = 397/946 (41%), Gaps = 115/946 (12%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F + +TG + +D+ +++ I S Q +++ + D N++AP+F +++
Sbjct: 406 FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPG--QASTVVVIDIVDCNNHAPLFNRSSY 463
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIE--KVIPSTGDSEHLFRILANGSIVL 187
+++E +P G+ V +V A D+D G G V YSI K +P + D G I
Sbjct: 464 DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYL-------GIIST 516
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
+ + Y Y ++A D G + F + + +FL + ++ D P F +
Sbjct: 517 SKPMDYELMKRIYTFRVRASDWG----SPFRREKEVSIFLQLRNLN--DNQPMFEEVNCT 570
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDRE 306
S+ +D G S++T+ A+D D+ N + Y I +FD+ GVI SL R
Sbjct: 571 GSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI----SLKRP 624
Query: 307 QL-LEADEEVQLQVTATETHLNIYGQEAKVSIWVT------------------------- 340
+ L A + + T + Y ++I V
Sbjct: 625 FINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTIL 684
Query: 341 --VRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDK 398
+ + + EF + S + + +F +D S I + DPD
Sbjct: 685 HFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDA 744
Query: 399 GSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-S 456
G NG + + G + F + E L+ V+A +DYE + V D
Sbjct: 745 GFNGKLVYVIADGNEEGCFDIELETG--------LLTVAAPLDYEATNFYILNVTVYDLG 796
Query: 457 VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQI 516
Q S ++T++++D ND+ P FP Y LT+ E + G+ + + + D D+ G++
Sbjct: 797 TPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAE-LTTKDADSEDNGRV 855
Query: 517 TYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATD----GGNLSSSTTL 572
Y+LL + + F + P++G + V LDRES+ Y L ++A D G L S T L
Sbjct: 856 RYTLL--SPTEKFSLHPLTGELVVTGH--LDRESEPRYILKVEARDQPSKGHQLFSVTDL 911
Query: 573 QIHLLDINDNAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPY 629
I L D+NDN+P +N E+ G V + A D D R + L+ G +
Sbjct: 912 IITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV--LMDGAH 969
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG-TKVNVTITVEDI 688
F +D TG L L+RE +D L++ SD G P+ T +V + V D+
Sbjct: 970 G-TFRVDLMTGALI----LERE-LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDV 1023
Query: 689 NDNL--PIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIR 745
N+NL P F + V+E P G V VV A D D F +G+G F I
Sbjct: 1024 NENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSIN 1083
Query: 746 GLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP 805
G + L P LD E + LTV A + ++ +V + V D NDNP
Sbjct: 1084 Q---DTGMIQ---TLAP---LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNP 1134
Query: 806 PTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGW 865
P + A + E+ V + A D D+S++ K ++ S +
Sbjct: 1135 PQMSQAVFYP-SIQEDAPVGTSVLQLDAWDPDSSSK----------GKLTFNITSGNYMG 1183
Query: 866 FSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNA 925
F + + ++ ++ +D E D L V D G + + +++ I DVNDN
Sbjct: 1184 FFMIHPVTGLLSTAQQLDRENKDEHILEV----TVLDNGEPSLKSTSRVVVGILDVNDNP 1239
Query: 926 PYFLPENKTF-VIIPELVLP--NREVASVRARDDDSGNNGVILFSI 968
P F +K F V +PE + P V + A D D G NG + +SI
Sbjct: 1240 PIF--SHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSI 1283
Score = 175 bits (443), Expect = 3e-43
Identities = 270/1050 (25%), Positives = 430/1050 (40%), Gaps = 169/1050 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMSGPNAYFFAVTPKTGEV 79
+P+ + + +PEDLP G +L A D D P + Y + F V TG +
Sbjct: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGAL 981
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQREML----VIVEDRNDN--APVFQNTAFSTSI 133
L LD+E + +++ SD + R L VIV D N+N P F + +
Sbjct: 982 ILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQV 1041
Query: 134 NETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSY 193
E P G+ V V A D D G G + Y + G F I + ++ +
Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLR-----AGTGLAAFSINQDTGMIQTLAPLD 1096
Query: 194 NNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAED 253
+++Y L + A D G ++ S + I V D D PQ + + S+ ED
Sbjct: 1097 REFASYYWLTVLAVDRG-------SVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQED 1149
Query: 254 AAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGSLDREQLLEAD 312
A GTSVL ++A D D + ++I+ G+F I G++ LDRE D
Sbjct: 1150 APVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRE---NKD 1206
Query: 313 EEVQLQVTATETHLNIYGQEA-KVSIWVTVRVMDVNDHKPEF----YNCSLPACTFTPEE 367
E + L+VT + G+ + K + V V ++DVND+ P F +N LP
Sbjct: 1207 EHI-LEVTVLDN-----GEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLP-------- 1252
Query: 368 AQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSA 427
E SP P +V D D+G NG S+ D EAFS+
Sbjct: 1253 ----------ERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSID-------- 1294
Query: 428 SVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT-----FPQ 482
V VS+ + + + ATDS S A V +H+ I RP+ F +
Sbjct: 1295 --LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLS-ASVRLHIEWIPWPRPSSIPLAFDE 1351
Query: 483 SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPG------NGADL---FQVDP 533
+ Y TV E TDP G I+ PG +G D F ++
Sbjct: 1352 TYYSFTVME--------------TDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEK 1397
Query: 534 VSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL---DINDNAP-VVSGS 589
+G++ + LD ++ Y LT++ TDG S + Q+H+ +IN + P +
Sbjct: 1398 TTGSIVI--ARPLDTRRRSNYNLTVEVTDG---SRTIATQVHIFMIANINHHRPQFLETR 1452
Query: 590 YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGP 647
Y + V ++ G + +QA D D+ + + + PG S F LDP +G+L +G
Sbjct: 1453 YEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSAS-LFQLDPSSGVLVTVGK 1511
Query: 648 LDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE 707
LD + P+ + LTV+V D P+ V VTI VED N + P F Q Y +V +
Sbjct: 1512 LDLGS-GPS---QHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDT 1567
Query: 708 -DPGVLVGVVKAWDADQTEANNRISFS-LSGSGANYFMIRGLVLGAGWAEGYLRLPPDVS 765
PG + V+A DAD+ N + +S L G+ +F I L+ G + L
Sbjct: 1568 IAPGTELLQVRAMDADR-GVNAEVHYSLLKGNSEGFFNINALL-------GIITLAQ--K 1617
Query: 766 LDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQH 825
LD LTV AE+ + V ++V + + P S + + E+
Sbjct: 1618 LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFS-KSEYFVEIPES-IPV 1675
Query: 826 GQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYE 885
G ++V++ + E++ N K GV FS+ + + I+ K +D+E
Sbjct: 1676 GSPILLVSAMSPSEVTYELREGN----KDGV---------FSMNSYSGL-ISTQKKLDHE 1721
Query: 886 ACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFV--------I 937
L +R ++A + +++ I D NDNAP FL TFV +
Sbjct: 1722 KISSYQLKIRGSNMA------GAFTDVMVVVDIIDENDNAPMFL--KSTFVGQISEAAPL 1773
Query: 938 IPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADV 997
++ N + A D D N ++++ IL + + F I D
Sbjct: 1774 YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALK----------FFKI------DP 1817
Query: 998 FAGSIQPVTSLDSTLQGTYQVTVQARDRPS 1027
G++ V+ +D ++Q V D+ S
Sbjct: 1818 SMGTLTIVSEMDYESMPSFQFCVYVHDQGS 1847
Score = 174 bits (442), Expect = 4e-43
Identities = 254/1044 (24%), Positives = 435/1044 (41%), Gaps = 137/1044 (13%)
Query: 32 SVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDY 87
S+ + E +P+ L A D D N L Y ++ N F + +TG + +A+ LDY
Sbjct: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDY 780
Query: 88 ETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVF 144
E + + ++V D P + + V V+D NDNAP F + +I+E VG+ +
Sbjct: 781 EATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA 840
Query: 145 SVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLEL 204
+ D D G V Y++ + P+ S H G +V+ G L ++ Y L++
Sbjct: 841 ELTTKDADSEDNGRVRYTL--LSPTEKFSLHPL----TGELVVTGHLDRESEPR-YILKV 893
Query: 205 KACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVE 264
+A D H F++ L I++ D D PQ + E V ED GT + ++
Sbjct: 894 EARDQPSKGHQLFSV-----TDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLD 948
Query: 265 AVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVN---GSLDREQLLEADEEV--QLQV 319
A D D G V Y + GA G RV+ G+L E+ L+ + L +
Sbjct: 949 ASDPDLGPAGEVRYVLMD---------GAHGTFRVDLMTGALILERELDFERRAGYNLSL 999
Query: 320 TATETHLNIYGQEAKVSIWVTVRVMDVND--HKPEFYNCSLPACTFTPEEAQVNFTGYVD 377
A++ + + V V V+DVN+ H P F A G V
Sbjct: 1000 WASDGGRPL---ARRTLCHVEVIVLDVNENLHPPHF--------------ASFVHQGQVQ 1042
Query: 378 EHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVS 436
E++ + + + D D G +G L G AFS++ + +++
Sbjct: 1043 ENSPSGTQV--IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG--------MIQTL 1092
Query: 437 ALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFPQSLYVLTVPEHSAT 495
A +D E + + V+A D S S V V I + D ND+ P Q+++ ++ E +
Sbjct: 1093 APLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPV 1152
Query: 496 GSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYY 555
G+ V + A DPD+ + G++T+++ GN F + PV+G ++ + LDRE++ +
Sbjct: 1153 GTSVLQ-LDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLST--AQQLDRENKDEHI 1209
Query: 556 LTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEEGNVS----VTIQAH 608
L + D G +L S++ + + +LD+NDN P+ S +N+ + E VS + A
Sbjct: 1210 LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVAS 1269
Query: 609 DNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVS 668
D DE N R+ +++ FS+D TG++ + + +LT+ +
Sbjct: 1270 DLDE--GLNGRVTYSIEDSD-EEAFSIDLVTGVVSSSSTFTAGEYN-------ILTIKAT 1319
Query: 669 DCGEPVLGTKVNVTI--TVEDINDNLPI-FNQSSYNFTVKEEDP-GVLVGVVKAWDADQT 724
D G+P L V + I ++P+ F+++ Y+FTV E DP +VGV+
Sbjct: 1320 DSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV-----E 1374
Query: 725 EANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPD 784
F++SG + G+ + LD + +NLTV +
Sbjct: 1375 GRPGLFWFNISGGDKDMDFDIEKTTGS--------IVIARPLDTRRRSNYNLTVEVTD-- 1424
Query: 785 PQGGETIVDV--CVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
G TI + ++N + P + + +RV ++ ++ V A D D L
Sbjct: 1425 --GSRTIATQVHIFMIANINHHRPQF-LETRYEVRVPQDTVPGVELLRVQAIDQDKGKSL 1481
Query: 843 EIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATD 902
I D GS F + + V + K TL V + D
Sbjct: 1482 ------IYTIHGSQDPGSA--SLFQLDPSSGVLVTVGKLDLGSGPSQHTLTV----MVRD 1529
Query: 903 PGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNG 962
N + I +ED N + P F + +P+ + P E+ VRA D D G N
Sbjct: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYE-ASVPDTIAPGTELLQVRAMDADRGVNA 1588
Query: 963 VILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQA 1022
+ +S+L+ + +G F+I + G I LD + +TV+A
Sbjct: 1589 EVHYSLLKGN----------SEGFFNI------NALLGIITLAQKLDQANHAPHTLTVKA 1632
Query: 1023 RDRPSLGPFLEATTTLNLFTVDQS 1046
D+ S AT ++++ D+S
Sbjct: 1633 EDQGSPQWHDLATVIIHVYPSDRS 1656
Score = 152 bits (385), Expect = 2e-36
Identities = 218/852 (25%), Positives = 360/852 (42%), Gaps = 124/852 (14%)
Query: 35 LPEDLPVGAQAFWLVAEDQDNDP---LTYGMSGPNAY-FFAVTPKTGEVKLASALDYETL 90
+ ED PVG L A D D+ LT+ ++ N FF + P TG + A LD E
Sbjct: 1146 IQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENK 1205
Query: 91 YTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETL-PVG-SVVFS 145
+ ++V D P ++ ++V + D NDN P+F + F+ + E L PV V+
Sbjct: 1206 DEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYR 1265
Query: 146 VLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELK 205
++A D D G G V YSIE D E L G + S S + L +K
Sbjct: 1266 LVASDLDEGLNGRVTYSIED-----SDEEAFSIDLVTGVV---SSSSTFTAGEYNILTIK 1317
Query: 206 ACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEA 265
A D G + S+ + + +P P E Y + + ++ V +
Sbjct: 1318 ATDSGQP-----PLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVIS 1372
Query: 266 VDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQL----QVT 320
V+G G+ ++IS + FDI G I + LD + + V++ +
Sbjct: 1373 VEGRPGL---FWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTI 1429
Query: 321 ATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHA 380
AT+ H+ + + ++N H+P+F + + V +
Sbjct: 1430 ATQVHIFM--------------IANINHHRPQFL--------------ETRYEVRVPQDT 1461
Query: 381 SPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPD---AEAFSVSPERAAGSASVQVLVRVSA 437
P + + L + D DKG + + + G D A F + P S+ V V V
Sbjct: 1462 VPGVEL--LRVQAIDQDKGKSLIYTIH-GSQDPGSASLFQLDP-----SSGVLVTVGKLD 1513
Query: 438 LVDYERQTAMAVQVVATD-SVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATG 496
L Q + V V + + +NF VTIH+ D N H P F Q Y +VP+ A G
Sbjct: 1514 LGSGPSQHTLTVMVRDQEIPIKRNF--VWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPG 1571
Query: 497 SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
+ + + A D D G ++ YSLL GN F ++ + G +T+ + LD+ + A + L
Sbjct: 1572 TELLQ-VRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITL--AQKLDQANHAPHTL 1628
Query: 557 TLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPG 614
T++A D G+ T+ IH+ + +AP+ S S FV+ E S+ + +
Sbjct: 1629 TVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKS-EYFVEIPE---SIPVGSPILLVSA 1684
Query: 615 TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV 674
+ S + + L G FS++ +GL+ LD E I + + G +
Sbjct: 1685 MSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKIS---------SYQLKIRGSNM 1735
Query: 675 LG--TKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP--GVLVG------VVKAWDADQT 724
G T V V + + D NDN P+F +S++ + E P +++ V+ A D+D+
Sbjct: 1736 AGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDK- 1794
Query: 725 EANNRISFS-LSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENP 783
EAN+ + + L +F I + G L + + +DYE+ P F V +
Sbjct: 1795 EANSLLVYKILEPEALKFFKIDP-------SMGTLTIVSE--MDYESMPSFQFCVYVHD- 1844
Query: 784 DPQGGETI-----VDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHG--QVAVVVASDV 836
QG + V ++V+DVND+PP S + VA G H ++ +V ASD
Sbjct: 1845 --QGSPVLFAPRPAQVIIHVRDVNDSPPRF---SEQIYEVAIVGPIHPGMELLMVRASDE 1899
Query: 837 DTSAQLEIQLVN 848
D+ I+ N
Sbjct: 1900 DSEVNYSIKTGN 1911
Score = 151 bits (382), Expect = 3e-36
Identities = 245/987 (24%), Positives = 398/987 (40%), Gaps = 122/987 (12%)
Query: 55 NDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREML 111
ND L+Y + F V A D E T ++ + V D P Q +
Sbjct: 1998 NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057
Query: 112 VIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTG 171
V +ED NDN P F++ + T I + G V+F V A D+D+G+ G V Y
Sbjct: 2058 VSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-------A 2110
Query: 172 DSEHLFRILAN-GSIVLNGSLSYN--NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLS 228
+ FRI G I L Y NK Y L++ A D G T ++Q V ++
Sbjct: 2111 EDYTYFRIDPYLGDISLKKPFDYQALNK---YHLKVIARDGG-----TPSLQSEEEVLVT 2162
Query: 229 ISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGW 288
+ + +P F +Y V E+ T +L +A +G+ +IY+I
Sbjct: 2163 V----RNKSNPLFQSPYYKVRVPENITLYTPILHTQA-RSPEGLR--LIYNIVEEEPLML 2215
Query: 289 FDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
F GV+ V G LD E+ + V AT+T L + + V V V DVN
Sbjct: 2216 FTTDFKTGVLTVTGPLD----YESKTKHVFTVRATDTALGSFSEAT-----VEVLVEDVN 2266
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F +Q+ +T + E + P+ L D + + ++ +
Sbjct: 2267 DNPPTF--------------SQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMV 466
G D F ++VQ L DYE Q V+V A D + +V
Sbjct: 2313 EDGSDVSKFFQINGSTGEMSTVQEL-------DYEAQQHFHVKVRAMDKGDPPLTGETLV 2365
Query: 467 TIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA 526
+++ DIND+ P F Q Y V E + G +V + A DPD+ ++ Y +L GN
Sbjct: 2366 VVNVSDINDNPPEFRQPQYEANVSELATCGHLVL-KVQAIDPDSRDTSRLEYLILSGNQD 2424
Query: 527 DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV 586
F ++ SG +++ N L + + Y L + A+DG T+ +++ N N
Sbjct: 2425 RHFFINSSSGIISMFN--LCKKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSP 2479
Query: 587 SGSYNIFVQEEEGNVSVTIQAHD---NDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLR 643
+++ E N V + D D+ + + ++ S FS++P+ G +
Sbjct: 2480 EFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPN-GQIA 2538
Query: 644 NLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFT 703
L LDRE + E I + V+ D G V V + +T D NDN P F S Y +
Sbjct: 2539 TLQKLDRE---NSTERVIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQFKASEYTVS 2593
Query: 704 VK---EEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRL 760
++ +D V+ V A+DAD+ + N +++S++ +++ V+ G +++
Sbjct: 2594 IQSNVSKDSPVI--QVLAYDADEGQ-NADVTYSVNPED----LVKD-VIEINPVTGVVKV 2645
Query: 761 PPD-VSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLD--VASLRGIR 817
V L+ +T F + A++ P ++V V + V + P + +
Sbjct: 2646 KDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPE 2702
Query: 818 VAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYIN 877
GS+ G V V A D + LV ++ D G FS+ + V I
Sbjct: 2703 DLPEGSEIGIVKAVAAQD-----PVIYSLVRGTTPESNKD------GVFSLDPDTGV-IK 2750
Query: 878 QSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVI 937
K +D+E+ L + V A L S N I + DVNDN P F + V+
Sbjct: 2751 VRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN----IQVGDVNDNRPVFEADPYKAVL 2806
Query: 938 IPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADV 997
+ + V V A D D+G +G + + + + P V +F D
Sbjct: 2807 TENMPV-GTSVIQVTAIDKDTGRDGQVSYRL----------SADPGSNVHELFA---IDS 2852
Query: 998 FAGSIQPVTSLDSTLQGTYQVTVQARD 1024
+G I + LD TY V A D
Sbjct: 2853 ESGWITTLQELDCETCQTYHFHVVAYD 2879
Score = 148 bits (373), Expect = 4e-35
Identities = 249/1032 (24%), Positives = 422/1032 (40%), Gaps = 150/1032 (14%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAED---QDNDPLTYGMSGPNAYFFAVTPKTGEV 79
AP+F + + ED VG L +D +DN + Y + P F++ P TGE+
Sbjct: 817 APRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK-FSLHPLTGEL 875
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQR-----EMLVIVEDRNDNAPVFQNTAFSTSIN 134
+ LD E+ + + + D + + ++++ +ED NDN+P +
Sbjct: 876 VVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVP 935
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH-LFRI-LANGSIVLNGSLS 192
E LP G+V+ + A D D+G AG V Y + D H FR+ L G+++L L
Sbjct: 936 EDLPPGTVLTFLDASDPDLGPAGEVRYVLM-------DGAHGTFRVDLMTGALILERELD 988
Query: 193 YNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
+ + A Y L L A D GG T+ C + V + V++ P F + V E
Sbjct: 989 FERR-AGYNLSLWASD-GGRPLARRTL-CHVEVI--VLDVNENLHPPHFASFVHQGQVQE 1043
Query: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEA 311
++ GT V+ V A D D G++ + Y + T F I D G+I+ LDR E
Sbjct: 1044 NSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDR----EF 1099
Query: 312 DEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN 371
L V A + +V I VT D ND+ P+ +Q
Sbjct: 1100 ASYYWLTVLAVDRGSVPLSSVTEVYIEVT----DANDNPPQM--------------SQAV 1141
Query: 372 FTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQ 430
F + E A + L + +DPD S G ++ G F + P V
Sbjct: 1142 FYPSIQEDAP--VGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP--------VT 1191
Query: 431 VLVRVSALVDYERQTAMAVQVVATDSVSQNF-SVAMVTIHLRDINDHRPTFPQSLYVLTV 489
L+ + +D E + ++V D+ + S + V + + D+ND+ P F L+ + +
Sbjct: 1192 GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRL 1251
Query: 490 PEH-SATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTV----TVRNGE 544
PE S + A+D D G G++TYS + + + F +D V+G V T GE
Sbjct: 1252 PERLSPVSPGPVYRLVASDLDEGLNGRVTYS-IEDSDEEAFSIDLVTGVVSSSSTFTAGE 1310
Query: 545 LLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP-----VVSGSYNIFVQEEEG 599
LT++ATD G S ++++H+ I P +Y F E
Sbjct: 1311 --------YNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETD 1362
Query: 600 NVSVTIQAHD-NDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
V+ + PG FN+ G +F ++ TG + PLD
Sbjct: 1363 PVNHMVGVISVEGRPGL----FWFNISGGDKDMDFDIEKTTGSIVIARPLDTRR-----R 1413
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED-PGVLVGVVK 717
LTV V+D G + T+V++ + +IN + P F ++ Y V ++ PGV + V+
Sbjct: 1414 SNYNLTVEVTD-GSRTIATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
Query: 718 AWDADQTEANNRISFSLSGS----GANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYET 770
A D D+ ++ + +++ GS A+ F + G+++ G LD +
Sbjct: 1472 AIDQDKGKS---LIYTIHGSQDPGSASLFQLDPSSGVLVTVG------------KLDLGS 1516
Query: 771 QP-VFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVA 829
P LTV + + V V ++V+D N +PP V + + ++
Sbjct: 1517 GPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEA-SVPDTIAPGTELL 1575
Query: 830 VVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDL 889
V A D D E V+ K + G+F++ A + I ++ +D
Sbjct: 1576 QVRAMDADRGVNAE---VHYSLLKGNSE------GFFNINALLGI-ITLAQKLDQANHAP 1625
Query: 890 VTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVA 949
TL V+ A D G + + +++I + + +AP F +++ FV IPE + +
Sbjct: 1626 HTLTVK----AEDQGSPQWHDLATVIIHVYPSDRSAPIF-SKSEYFVEIPESIPVGSPIL 1680
Query: 950 SVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLD 1009
V A S V + ++G GVFS+ + ++G I LD
Sbjct: 1681 LVSA------------MSPSEVTYELREGNK---DGVFSM------NSYSGLISTQKKLD 1719
Query: 1010 STLQGTYQVTVQ 1021
+YQ+ ++
Sbjct: 1720 HEKISSYQLKIR 1731
Score = 136 bits (343), Expect = 1e-31
Identities = 239/1082 (22%), Positives = 417/1082 (38%), Gaps = 183/1082 (16%)
Query: 21 NVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTG 77
++ P F V + ED+P+ + + A D D N Y + + FA+ P +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFN-TRSEMFAIHPTSG 201
Query: 78 EVKLASALDYETLYTFKVTISVSDPYIQVQR--------EMLVIVEDRNDNAPVFQNTAF 129
V +A L+ ++ + D ++ ++V VE P +
Sbjct: 202 VVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE------PALRKPPA 255
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANG---SIV 186
S+ T P + + V D S+G V S+E V G + A S+V
Sbjct: 256 IASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLV 315
Query: 187 LNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFY 246
+++ + L L+A G Y + LP S+ +F + Y
Sbjct: 316 SVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSL--------KFEKAVY 367
Query: 247 SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDRE 306
++E + G+ V+ V P ++ Y +P ++G R G +
Sbjct: 368 RVQLSEFSPPGSRVVMVRVT--------PAFPNLQYVLKPSSENVGFKLNART-GLITTT 418
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
+L++ + Q L+I + S V + ++D N+H P F S
Sbjct: 419 KLMDFHDRAHYQ-------LHIRTSPGQASTVVVIDIVDCNNHAPLFNRSS--------- 462
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGS 426
+ G +DE+ P + L + D D G NG S+ GP A FS+ P
Sbjct: 463 -----YDGTLDENIPPGTSV--LAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLG--- 512
Query: 427 ASVQVLVRVSALVDYE-RQTAMAVQVVATD--SVSQNFSVAMVTIHLRDINDHRPTFPQS 483
++ S +DYE + +V A+D S + + + LR++ND++P F +
Sbjct: 513 -----IISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEV 567
Query: 484 LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNG 543
++ + G + ++ A D D + Y ++ GN + F ++ SG ++++
Sbjct: 568 NCTGSIRQDWPVGKSIM-TMSAIDVD--ELQNLKYEIVSGNELEYFDLNHFSGVISLKRP 624
Query: 544 EL-LDRESQAVYYLTLQATDGGNLSSSTTLQIHLL-DINDNAPVVSGSYNIFVQ------ 595
+ L Y L + A+DG N +S TTL I ++ D + PV + Q
Sbjct: 625 FINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTIL 684
Query: 596 ------------EEEGNVSV------TIQAHDN-----------------------DEPG 614
EE ++S T Q D+ D
Sbjct: 685 HFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDA 744
Query: 615 TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV 674
N +L++ + G F ++ +TGLL PLD EA + +L V V D G P
Sbjct: 745 GFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATN-----FYILNVTVYDLGTPQ 799
Query: 675 LGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFS 733
+ +T+ V+D NDN P F Y T+ E+ + G + + DAD +E N R+ ++
Sbjct: 800 KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDAD-SEDNGRVRYT 858
Query: 734 LSGSGANYFM--IRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGE-- 789
L + + + G ++ G LD E++P + L V A + +G +
Sbjct: 859 LLSPTEKFSLHPLTGELVVTG------------HLDRESEPRYILKVEARDQPSKGHQLF 906
Query: 790 TIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNI 849
++ D+ + ++DVNDN P + ++V E+ + + ASD D E++ V
Sbjct: 907 SVTDLIITLEDVNDNSPQC-ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV-- 963
Query: 850 LCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYS 909
+ G F V I + + +D+E L + A D +
Sbjct: 964 --------LMDGAHGTFRVDLMTGALILE-RELDFERRAGYNLSLWASDGGRPLARRTLC 1014
Query: 910 NNGSLLITIEDVNDNAPYFLPENKTFV---IIPELVLPNREVASVRARDDDSGNNGVILF 966
+ + + + DVN+N P +FV + E +V V A+DDDSG +G
Sbjct: 1015 H---VEVIVLDVNEN--LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDG---- 1065
Query: 967 SILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRP 1026
+ + + G + FSI + G IQ + LD Y +TV A DR
Sbjct: 1066 ---ELQYFLRAGTGL---AAFSINQDT------GMIQTLAPLDREFASYYWLTVLAVDRG 1113
Query: 1027 SL 1028
S+
Sbjct: 1114 SV 1115
Score = 133 bits (335), Expect = 1e-30
Identities = 206/899 (22%), Positives = 367/899 (40%), Gaps = 140/899 (15%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREM-LVIVEDRNDNAPVFQNTA 128
F + TG + +A LD + +T+ V+D + ++ + ++ + N + P F T
Sbjct: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETR 1452
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVL 187
+ + + G + V A+D+D G + ++Y+I S LF++ ++G +V
Sbjct: 1453 YEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHG--SQDPGSASLFQLDPSSGVLVT 1508
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
G L + + + L + D F V+++I V D P+F + Y
Sbjct: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNF-------VWVTIHVEDGNLHPPRFTQLHYE 1561
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDRE 306
ASV + A GT +L V A+D D+G+N V YS+ G+F+I A G+I + LD
Sbjct: 1562 ASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD-- 1619
Query: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366
Q L + ++ W + + ++ Y A F+
Sbjct: 1620 -----------QANHAPHTLTVKAEDQGSPQWHDLATVIIH-----VYPSDRSAPIFSKS 1663
Query: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGS 426
E V IP+ ++V S T+ L G D FS++
Sbjct: 1664 EYFVEIP--------ESIPVGSPILLV-SAMSPSEVTYELREGNKDG-VFSMN------- 1706
Query: 427 ASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYV 486
S L+ +D+E+ ++ +++ ++ F+ MV + + D ND+ P F +S +V
Sbjct: 1707 -SYSGLISTQKKLDHEKISSYQLKIRGSNMAGA-FTDVMVVVDIIDENDNAPMFLKSTFV 1764
Query: 487 LTVPEHSATGSVVTDS------IHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV 540
+ E + S++ D IHA+D D A + Y +L F++DP GT+T+
Sbjct: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI 1824
Query: 541 RNGELLDRESQAVYYLTLQATDGGN----LSSSTTLQIHLLDINDNAPVVSGS-YNIFV- 594
+ +D ES + + D G+ + IH+ D+ND+ P S Y + +
Sbjct: 1825 VSE--MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIV 1882
Query: 595 -QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGP----LD 649
G + ++A D D S + +++ G ++ P TG + L P L
Sbjct: 1883 GPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLS 1936
Query: 650 REAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE--E 707
R+ A +G T LV I++ + D F+Q Y VKE +
Sbjct: 1937 RKLTIRASDGLYQDTALVK--------------ISLTQVLDKSLQFDQDVYWAAVKENLQ 1982
Query: 708 DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLD 767
D LV A N+ +S+ L + M++ + G L+ V+ D
Sbjct: 1983 DRKALV----ILGAQGNHLNDTLSYFLLNGTDMFHMVQ--------SAGVLQ-TRGVAFD 2029
Query: 768 YETQPVFNLTVSA-ENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHG 826
E Q L V +N PQ + V V+++DVNDNPP L + ++G++ G
Sbjct: 2030 REQQDTHELAVEVRDNRTPQRVAQGL-VRVSIEDVNDNPPKF--KHLPYYTIIQDGTEPG 2086
Query: 827 QVAVVVAS---DVDTSAQLEIQLVNILCTKAGVD--VGSLCWGWFSVAANGSVYINQSKA 881
V V++ D+ T+ + + T +D +G I+ K
Sbjct: 2087 DVLFQVSATDEDLGTNGAVTYEFAEDY-TYFRIDPYLGD---------------ISLKKP 2130
Query: 882 IDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVND---NAPYF---LPENKT 934
DY+A + L V +A D G + + +L+T+ + ++ +PY+ +PEN T
Sbjct: 2131 FDYQALNKYHLKV----IARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENIT 2185
Score = 130 bits (328), Expect = 6e-30
Identities = 237/980 (24%), Positives = 393/980 (40%), Gaps = 126/980 (12%)
Query: 14 LVVSVAANVAPKFLANMTSV-ILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF--- 69
+V+ V N+ P A+ + E+ P G Q + A+D D+ G+ G YF
Sbjct: 1019 IVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS-----GLDGELQYFLRA 1073
Query: 70 ------FAVTPKTGEVKLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRND 119
F++ TG ++ + LD E + +T+ D P V E+ + V D ND
Sbjct: 1074 GTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVT-EVYIEVTDAND 1132
Query: 120 NAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI 179
N P F SI E PVG+ V + A D D S G + ++I ++G+ F I
Sbjct: 1133 NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNI-----TSGNYMGFFMI 1187
Query: 180 L-ANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLD 238
G + L NK + LE+ D G +++ + V + ++D D
Sbjct: 1188 HPVTGLLSTAQQLDRENKDE-HILEVTVLDNGEP-----SLKSTSRVV--VGILDVNDNP 1239
Query: 239 PQFVREFYSASVAEDAAKGTS--VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGV 296
P F + ++ + E + + V + A D D+G+N V YSI S D A +
Sbjct: 1240 PIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS------DEEAFSI 1293
Query: 297 IRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNC 356
V G + A E L + AT++ + +S V + + + +P
Sbjct: 1294 DLVTGVVSSSSTFTAGEYNILTIKATDSG------QPPLSASVRLHIEWIPWPRPS---- 1343
Query: 357 SLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAF 416
S+P +E +FT + P++ + V+ +G G F ++ G D +
Sbjct: 1344 SIPLAF---DETYYSFTVMETD------PVNHMVGVI--SVEGRPGLFWFNISGGDKD-M 1391
Query: 417 SVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDH 476
E+ GS + ++ +D R++ + V TD S+ + + + +IN H
Sbjct: 1392 DFDIEKTTGS------IVIARPLDTRRRSNYNLTVEVTDG-SRTIATQVHIFMIANINHH 1444
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLL----PGNGADLFQVD 532
RP F ++ Y + VP+ + G V + A D D G + Y++ PG+ A LFQ+D
Sbjct: 1445 RPQFLETRYEVRVPQDTVPG-VELLRVQAIDQDKGK--SLIYTIHGSQDPGS-ASLFQLD 1500
Query: 533 PVSGT-VTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSG-SY 590
P SG VTV +L SQ + ++ + + + IH+ D N + P + Y
Sbjct: 1501 PSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHY 1560
Query: 591 NIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDR 650
V + + +Q D N+ + ++LL G F+++ G++ LD+
Sbjct: 1561 EASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQ 1620
Query: 651 EAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP- 709
P LTV D G P V I V + + PIF++S Y + E P
Sbjct: 1621 ANHAPH-----TLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPV 1675
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRL-PPDVSLDY 768
G + +V A +S S Y + G G Y L LD+
Sbjct: 1676 GSPILLVSA---------------MSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDH 1720
Query: 769 ETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQV 828
E + L + N G T V V V++ D NDN P ++ G +++E + +
Sbjct: 1721 EKISSYQLKIRGSNM--AGAFTDVMVVVDIIDENDNAPMFLKSTFVG-QISEAAPLYSMI 1777
Query: 829 A-------VVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKA 881
V+ ASD D A + + IL +A +F + + S+
Sbjct: 1778 MDKNNNPFVIHASDSDKEAN-SLLVYKILEPEA--------LKFFKIDPSMGTLTIVSE- 1827
Query: 882 IDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPEL 941
+DYE+ V D + F ++I + DVND+ P F E V I
Sbjct: 1828 MDYESMPSFQFCVYVHDQGSPVLFAP--RPAQVIIHVRDVNDSPPRF-SEQIYEVAIVGP 1884
Query: 942 VLPNREVASVRARDDDSGNN 961
+ P E+ VRA D+DS N
Sbjct: 1885 IHPGMELLMVRASDEDSEVN 1904
Score = 47.4 bits (111), Expect = 9e-05
Identities = 29/105 (27%), Positives = 53/105 (50%), Gaps = 3/105 (2%)
Query: 436 SALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSAT 495
+AL++ E + + + + AT+ + ++ V +H+ D ND +P F Y +T+ E
Sbjct: 104 TALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPL 163
Query: 496 GSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV 540
S + + ATD D G + Y+ +++F + P SG VTV
Sbjct: 164 KSPIC-KVTATDADLGQNAEFYYAF--NTRSEMFAIHPTSGVVTV 205
Score = 43.9 bits (102), Expect = 0.001
Identities = 51/232 (21%), Positives = 98/232 (42%), Gaps = 27/232 (11%)
Query: 66 NAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVE--DRNDNAPV 123
N F + K+ L L+ E ++ + I ++ ++++ V+V D+ND P+
Sbjct: 91 NFCFLRIRTKSSNTAL---LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL 147
Query: 124 FQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANG 183
F ++ +I+E +P+ S + V A D D+G Y+ SE +G
Sbjct: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNT------RSEMFAIHPTSG 201
Query: 184 SIVLNGSLSYNNKSAFYQLELKACD----------LGGMYHNTFTIQCSL--PVFLSISV 231
+ + G L+ + ++L++ A D G + ++ +L P ++ V
Sbjct: 202 VVTVAGKLNVTWRGK-HELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV 260
Query: 232 VDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYS 283
V PD + Y+ + + + G V +VE V GD G + I S + S
Sbjct: 261 VTPPDSNDGTT---YATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARS 309
Score = 43.1 bits (100), Expect = 0.002
Identities = 47/184 (25%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 480 FPQSLYVLTVPEHSATGSVVTD----SIHATDPDTGAWGQITYSLLPGNGADLFQVDP-- 533
F S Y T+ E+S+ + V I+ +P W + Y ++ G+ A++F+ +
Sbjct: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQ---WA-VRYRIISGDVANVFKTEEYV 88
Query: 534 VSGTVTVR------NGELLDRESQAVYYLTLQATDGG-NLSSSTTLQIHLLDINDNAPVV 586
V +R N LL+RE + Y L +QAT+ L + T + +H+LD ND P+
Sbjct: 89 VGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLF 148
Query: 587 S-GSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S SY + + E+ S + D N+ + S F++ P +G++
Sbjct: 149 SPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF--NTRSEMFAIHPTSGVVTVA 206
Query: 646 GPLD 649
G L+
Sbjct: 207 GKLN 210
Score = 32.3 bits (72), Expect = 3.1
Identities = 68/304 (22%), Positives = 117/304 (38%), Gaps = 47/304 (15%)
Query: 788 GETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLV 847
G+ V +++ D N++ P + +S G + EN V V A+D D +
Sbjct: 438 GQASTVVVIDIVDCNNHAPLFNRSSYDGT-LDENIPPGTSVLAVTATDRDHGENGYVTY- 495
Query: 848 NILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLV-TLVVRACDLATDPGFQ 906
+I KA FS+ + I+ SK +DYE + T VRA D + F+
Sbjct: 496 SIAGPKALP---------FSIDPYLGI-ISTSKPMDYELMKRIYTFRVRASDWGSP--FR 543
Query: 907 AYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILF 966
S+ + + ++NDN P F N T I R D ++
Sbjct: 544 R-EKEVSIFLQLRNLNDNQPMFEEVNCTGSI----------------RQDWPVGKSIMTM 586
Query: 967 SILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRP 1026
S + VD + I F + +P +L + +Y + + A D
Sbjct: 587 SAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASD-- 644
Query: 1027 SLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQD 1086
G + TTLN+ V + F P V ++ + LTQ T+T ++ + +Q+
Sbjct: 645 --GKNYASPTTLNITVVKDPH-----FEVP---VTCDKTGV---LTQFTKTILHFIGLQN 691
Query: 1087 IDSA 1090
+S+
Sbjct: 692 QESS 695
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 202 bits (515), Expect = 1e-51
Identities = 234/855 (27%), Positives = 367/855 (42%), Gaps = 91/855 (10%)
Query: 25 KFLANMTSVILPEDLPVGAQAFWLVAE---DQDNDPLTYGMSG----PNAYFFAVTPKTG 77
KF V L E+ P G L A + + + ++Y M G + +F + TG
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 78 EVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSIN 134
V S LD ET T + + D P + V+V+D ND++PVF+ + + +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 135 ETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYN 194
E L VG V ++ A D+D + Y + G + +F++ + +V ++
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRV------LGGAWDVFQLNESSGVVSTRAVLDR 417
Query: 195 NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDA 254
++A YQL ++A D G N + + V+ I V D+ D PQF + Y V ED
Sbjct: 418 EEAAEYQLLVEANDQG---RNPGPLSATATVY--IEVEDENDNYPQFSEQNYVVQVPEDV 472
Query: 255 AKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGSLDREQLLEADE 313
T+VL V+A D D+G N + YSI G F + G++ V LD E + +
Sbjct: 473 GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL 532
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
++ Q +N G V+V+V+DVND++P F + F
Sbjct: 533 SIKAQDGGRPPLINSSGV-------VSVQVLDVNDNEPIFVSSP--------------FQ 571
Query: 374 GYVDEHASPRIPIDDLTMVVYDPDKGSNG--------TFLLSLGGPDA--EAFSVSPERA 423
V E+ P+ + V D D G N T LGG A + + +P+
Sbjct: 572 ATVLENVPLGYPVVHIQAV--DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFP 629
Query: 424 AGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVA-MVTIHLRDINDHRPTFPQ 482
+ + V A +D E + V A D S S + V+I + D+ND+ P F Q
Sbjct: 630 FQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ 689
Query: 483 SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRN 542
Y L + E +A GS V ++ A D D + ITY L GN + F + G +
Sbjct: 690 PTYELRLNEDAAVGSSVL-TLQARDRDANS--VITYQLTGGNTRNRFALSSQRGGGLITL 746
Query: 543 GELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEE--G 599
LD + + Y L + A+D G S + + I++ D N + PV S Y + V E+ G
Sbjct: 747 ALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
Query: 600 NVSVTIQAHDNDEPGTNNSRLLFNLL-PGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
T+ A NDE N+R+ + + P P F +DPD+G + + LD E +
Sbjct: 806 TSIATLSA--NDEDTGENARITYVIQDPVP---QFRIDPDSGTMYTMMELDYEN-----Q 855
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVK 717
LT++ D G P + I + D NDN P F Y ++ E+ P + V
Sbjct: 856 VAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVS 915
Query: 718 AWDADQTEANNRISFSLSG--SGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFN 775
A D D + N R+ ++ G G F I G +R LD E V+N
Sbjct: 916 ATDRD-SGPNGRLLYTFQGGDDGDGDFYIEP-------TSGVIR--TQRRLDRENVAVYN 965
Query: 776 L-TVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L ++ + P V++ V + D+NDN P + L + V EN VA + A+
Sbjct: 966 LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRAN 1024
Query: 835 DVD--TSAQLEIQLV 847
D D +AQ+ Q+V
Sbjct: 1025 DPDEGPNAQIMYQIV 1039
Score = 188 bits (478), Expect = 3e-47
Identities = 253/962 (26%), Positives = 400/962 (41%), Gaps = 160/962 (16%)
Query: 129 FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVL 187
+ ++ E P G+++ + A G V Y +E + S FRI A G++
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDER--SRGYFRIDSATGAVST 307
Query: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247
+ L K + L +KA D T S ++++ V D D P F + Y
Sbjct: 308 DSVLDRETKET-HVLRVKAVDYS-------TPPRSATTYITVLVKDTNDHSPVFEQSEYR 359
Query: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI----GADGVIRVNGSL 303
V E+ G VLT+ A D D IN ++ Y G +D+ + GV+ L
Sbjct: 360 ERVRENLEVGYEVLTIRASDRDSPINA----NLRYRVLGGAWDVFQLNESSGVVSTRAVL 415
Query: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTF 363
DRE+ E QL V A + N A ++++ V D ND+ P+F
Sbjct: 416 DREEAAE----YQLLVEANDQGRNPGPLSATATVYIEVE--DENDNYPQF---------- 459
Query: 364 TPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS-LGGPDAEAFSVSPER 422
++ N+ V E + L + D D+G N S L G A F +
Sbjct: 460 ----SEQNYVVQVPEDVGLNTAV--LRVQATDRDQGQNAAIHYSILSGNVAGQFYLH--- 510
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF--SVAMVTIHLRDINDHRPTF 480
S+ ++ V +D+E ++ + A D S +V++ + D+ND+ P F
Sbjct: 511 -----SLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565
Query: 481 PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLL-------------PGNGAD 527
S + TV E+ G V I A D D+G ++ Y L+ P N A
Sbjct: 566 VSSPFQATVLENVPLGYPVVH-IQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAP 624
Query: 528 L----FQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDIND 581
FQ+ SG +TV LDRE Y ++A D G+ +SSST++ I +LD+ND
Sbjct: 625 TPDFPFQIHNSSGWITVCAE--LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVND 682
Query: 582 NAPVVSG-SYNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPD 638
N PV + +Y + + E+ G+ +T+QA D D NS + + L G + F+L
Sbjct: 683 NDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA----NSVITYQLTGGNTRNRFALSSQ 738
Query: 639 TG--LLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK---VNVTITVEDINDNLP 693
G L+ PLD + E + VL V SD GT+ +V I V D N + P
Sbjct: 739 RGGGLITLALPLDYKQ-----EQQYVLAVTASD------GTRSHTAHVLINVTDANTHRP 787
Query: 694 IFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAG 752
+F S Y +V E+ P G + + A D D E N RI++ + +
Sbjct: 788 VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGE-NARITYVIQDPVPQF----------- 835
Query: 753 WAEGYLRLPPD-------VSLDYETQPVFNLTVSAE-NPDPQGGETIVDVCVNVKDVNDN 804
R+ PD + LDYE Q + LT+ A+ N PQ +T + + + D NDN
Sbjct: 836 ------RIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTT-LEILILDANDN 888
Query: 805 PPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWG 864
P +G + E+ + V A+D D+ +L T G D G G
Sbjct: 889 APQFLWDFYQG-SIFEDAPPSTSILQVSATDRDSGPN-----GRLLYTFQGGDDGD---G 939
Query: 865 WFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDN 924
F + V I + +D E + L A D + A + + +TI D+NDN
Sbjct: 940 DFYIEPTSGV-IRTQRRLDRENVAVYNLWALAVDRGSPTPLSA---SVEIQVTILDINDN 995
Query: 925 APYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQ 984
AP F +++ + + E VA +RA D D G N I++ I+ D +
Sbjct: 996 APMF-EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGD----------MR 1044
Query: 985 GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
F + D+ G ++ + LD ++ Y + VQA P L + T+++ VD
Sbjct: 1045 HFFQL------DLLNGDLRAMVELDFEVRREYVLVVQATSAP-----LVSRATVHILLVD 1093
Query: 1045 QS 1046
Q+
Sbjct: 1094 QN 1095
Score = 188 bits (477), Expect = 3e-47
Identities = 202/742 (27%), Positives = 337/742 (45%), Gaps = 96/742 (12%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYG-MSGPNAYFFAVTPKTGEV 79
P+F V +PED+ + + A D+D N + Y +SG A F + +G +
Sbjct: 457 PQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGIL 516
Query: 80 KLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
+ + LD+E + + ++I D P I + V V D NDN P+F ++ F ++ E
Sbjct: 517 DVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLE 576
Query: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIP------STGDS------EHLFRIL-AN 182
+P+G V + AVD D G + Y + S G + F+I ++
Sbjct: 577 NVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSS 636
Query: 183 GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242
G I + L + Y ++A D G ++ T +SI+V+D D DP F
Sbjct: 637 GWITVCAELD-REEVEHYSFGVEAVDHGSPPMSSSTS-------VSITVLDVNDNDPVFT 688
Query: 243 REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGAD---GVIRV 299
+ Y + EDAA G+SVLT++A D D N + Y ++ F + + G+I +
Sbjct: 689 QPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITL 746
Query: 300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD +Q +++ L VTA++ G + + V + V D N H+P F +
Sbjct: 747 ALPLDYKQ----EQQYVLAVTASD------GTRSHTA-HVLINVTDANTHRPVFQSS--- 792
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
++T V E I T+ D D G N + P + F +
Sbjct: 793 -----------HYTVSVSEDRPVGTSI--ATLSANDEDTGENARITYVIQDPVPQ-FRID 838
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRP 478
P+ S ++ ++ + DYE Q A + ++A D+ + Q + I + D ND+ P
Sbjct: 839 PD----SGTMYTMMEL----DYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP 890
Query: 479 TFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADL-FQVDPVSGT 537
F Y ++ E + + + + ATD D+G G++ Y+ G+ D F ++P SG
Sbjct: 891 QFLWDFYQGSIFEDAPPSTSILQ-VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 538 VTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+ R LDRE+ AVY L A D G+ LS+S +Q+ +LDINDNAP+ +F
Sbjct: 950 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 594 VQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDRE 651
V+E G+V I+A+D DE N+++++ ++ G H F LD G LR + LD
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGP--NAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELD-- 1063
Query: 652 AIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDN---LPIFNQSSYNFTVKEED 708
E R ++V P++ ++ V I + D NDN LP F N+ + +
Sbjct: 1064 -----FEVRREYVLVVQATSAPLV-SRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 1117
Query: 709 --PGVLVGVVKAWDADQTEANN 728
P ++G + A D D +++ N
Sbjct: 1118 SFPTGVIGCIPAHDPDVSDSLN 1139
Score = 142 bits (358), Expect = 2e-33
Identities = 153/569 (26%), Positives = 249/569 (43%), Gaps = 70/569 (12%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNAYF-FAVTPKTGE--V 79
P F + L ED VG+ L A D+D N +TY ++G N FA++ + G +
Sbjct: 685 PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLI 744
Query: 80 KLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPV 139
LA LDY+ + + ++ SD +L+ V D N + PVFQ++ ++ S++E PV
Sbjct: 745 TLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPV 804
Query: 140 GSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSA 198
G+ + ++ A D+D G + Y I+ +P FRI +G++ L Y N+ A
Sbjct: 805 GTSIATLSANDEDTGENARITYVIQDPVPQ-------FRIDPDSGTMYTMMELDYENQVA 857
Query: 199 FYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
Y L + A D G Q S L I ++D D PQF+ +FY S+ EDA T
Sbjct: 858 -YTLTIMAQDNG-------IPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 259 SVLTVEAVDGDKGINDPVIYSI-SYSTRPGWFDI-GADGVIRVNGSLDREQLLEADEEVQ 316
S+L V A D D G N ++Y+ G F I GVIR LDRE + +
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 317 LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYV 376
+ T L+ S+ + V ++D+ND+ P F L +V
Sbjct: 970 AVDRGSPTPLS-------ASVEIQVTILDINDNAPMFEKDELEL--------------FV 1008
Query: 377 DEHASPRIPIDDLTMVV--YDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVR 434
+E+ P+ + + DPD+G N + + D F + + ++ +V
Sbjct: 1009 EENN----PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF---QLDLLNGDLRAMVE 1061
Query: 435 VSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQ-----SLYVLTV 489
+ + R+ + VQ + VS+ A V I L D ND+ P P + YV
Sbjct: 1062 LD--FEVRREYVLVVQATSAPLVSR----ATVHILLVDQNDNPPVLPDFQILFNNYVTNK 1115
Query: 490 PEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRE 549
TG V I A DPD + Y+ + GN L +DP +G + + LD
Sbjct: 1116 SNSFPTG--VIGCIPAHDPDVS--DSLNYTFVQGNELRLLLLDPATGELQLSRD--LDNN 1169
Query: 550 SQAVYYLTLQATDG-GNLSSSTTLQIHLL 577
+ + +DG ++++ TL++ ++
Sbjct: 1170 RPLEALMEVSVSDGIHSVTAFCTLRVTII 1198
Score = 66.6 bits (161), Expect = 1e-10
Identities = 80/316 (25%), Positives = 135/316 (42%), Gaps = 27/316 (8%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMSG--PNAY 68
+++ A + AP+FL + + ED P + A D+D+ P L Y G
Sbjct: 880 ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKV-TISV---SDPYIQVQREMLVIVEDRNDNAPVF 124
F + P +G ++ LD E + + + ++V S + E+ V + D NDNAP+F
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
Query: 125 QNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANG 183
+ + E PVGSVV + A D D G ++Y I + GD H F++ L NG
Sbjct: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE-----GDMRHFFQLDLLNG 1054
Query: 184 SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243
+ L + + Y L ++A + T I L + D P + P F
Sbjct: 1055 DLRAMVELDFEVRRE-YVLVVQATSAPLVSRATVHI-------LLVDQNDNPPVLPDFQI 1106
Query: 244 EFYSASVAEDAAKGTSVL-TVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNG 301
F + + + T V+ + A D D ++D + Y+ + A G ++++
Sbjct: 1107 LFNNYVTNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSR 1164
Query: 302 SLDREQLLEADEEVQL 317
LD + LEA EV +
Sbjct: 1165 DLDNNRPLEALMEVSV 1180
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 177 bits (449), Expect = 6e-44
Identities = 203/751 (27%), Positives = 310/751 (41%), Gaps = 97/751 (12%)
Query: 35 LPEDLPVG------------------AQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKT 76
LPE++P+G A + + + PL +S F + +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVK-VSSSTGEIFTTSNRI 92
Query: 77 GEVKLASALDY----ETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTS 132
KL + Y E + +V I +D + ++ + +IV+D NDNAP+F + + S
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIK--IKIIVKDTNDNAPMFPSPVINIS 150
Query: 133 INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN------GSIV 186
I E + S A D D G G+ Y + G S I+ ++
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYEL-----LNGQSVFGLDIVETPEGEKWPQLI 205
Query: 187 LNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFY 246
+ +L K Y +++K D G T Q S L ++V D D P F
Sbjct: 206 VQQNLDREQKDT-YVMKIKVEDGG-------TPQKSSTAILQVTVSDVNDNRPVFKEGQV 257
Query: 247 SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA----DGVIRVNGS 302
+ E+A GTSV+ + A D D G N + Y P + A G+I V S
Sbjct: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS 317
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LDRE+ A +V T L G VT+ V DVND+ P N L
Sbjct: 318 LDREE--TAIHKV--------TVLASDGSSTPARATVTINVTDVNDNPP---NIDLRYII 364
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
+ +N T Y+ E I +T V D D NG + + + E P
Sbjct: 365 -----SPINGTVYLSEKDPVNTKIALIT--VSDKDTDVNGKVICFI---EREV----PFH 410
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFP 481
Q L+ S+L+DYE + ++VA+DS + + A+V + L D ND+ P F
Sbjct: 411 LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
Q + L+V E++ G +T +I ATD D+G I Y L G A F +D +G +T
Sbjct: 471 QPVIELSVSENNRRGLYLT-TISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTA- 526
Query: 542 NGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEE 598
+ DRE Q + T+ A D G L S + + +LD NDN+P + FV E
Sbjct: 527 -SRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 599 GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
S D N + ++L + NF LDP +G++++ DRE +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILND--NDNFVLDPYSGVIKSNVSFDREQ-----Q 638
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDPGVLVG 714
V +D G+P + VTI V D+NDN P+ + +S+ PG +V
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
Query: 715 VVKAWDADQTEANNRISFSL-SGSGANYFMI 744
V A D D T N + +++ SG+ F I
Sbjct: 699 EVFAVDVD-TGMNAELKYTIVSGNNKGLFRI 728
Score = 164 bits (416), Expect = 4e-40
Identities = 190/736 (25%), Positives = 310/736 (42%), Gaps = 89/736 (12%)
Query: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEAD 312
+AA GTS V + G D + +S ST + + +DRE+L
Sbjct: 53 NAATGTSASLVYRLVSKAG--DAPLVKVSSSTGE---------IFTTSNRIDREKLCAGA 101
Query: 313 EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFT-PEEAQVN 371
+ E + I + I + + V D ND+ P F + P + PE +N
Sbjct: 102 SYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS---PVINISIPENTLIN 158
Query: 372 FTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQV 431
R PI T DPD G NG L + E G Q+
Sbjct: 159 ----------SRFPIPSAT----DPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
Query: 432 LVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVP 490
+V+ + +D E++ +++ D Q S A++ + + D+ND+RP F + + +P
Sbjct: 205 IVQQN--LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 491 EHSATGSVVTDSIHATDPDTGAWGQITY----SLLPGNGADLFQVDPVSGTVTVRNGELL 546
E++ G+ V +HATD D G+ +I Y + P LF ++ +G +TV+ L
Sbjct: 263 ENAPVGTSVIQ-LHATDADIGSNAEIRYIFGAQVAPATKR-LFALNNTTGLITVQRS--L 318
Query: 547 DRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-------NIFVQEEEG 599
DRE A++ +T+ A+DG + + T+ I++ D+NDN P + Y +++ E++
Sbjct: 319 DREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 600 -NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
N + + + + N + F P+ H ++ + LL LD E
Sbjct: 379 VNTKIALITVSDKDTDVNGKVICFIEREVPF-HLKAVYDNQYLLETSSLLDYEGTK---- 433
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVK 717
++ SD G+P L V + +ED NDN PIFNQ +V E + G+ + +
Sbjct: 434 -EFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTIS 492
Query: 718 AWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVFN 775
A D D + N I + L G A++F + + VL A D E Q F
Sbjct: 493 ATDEDSGK-NADIVYQL-GPNASFFDLDRKTGVLTASRV-----------FDREEQERFI 539
Query: 776 LTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASD 835
TV+A + ++ V V V D NDN P + V+EN ++ V V+ +D
Sbjct: 540 FTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF-VSENLPKYSTVGVITVTD 598
Query: 836 VDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVR 895
D + L +IL V S I + + D E T V+
Sbjct: 599 ADAGENKAVTL-SILNDNDNF-----------VLDPYSGVIKSNVSFDREQQSSYTFDVK 646
Query: 896 ACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL--PENKTFVIIPELVLPNREVASVRA 953
A TD G S+ + I + DVNDN+P + P N +F ++P +P VA V A
Sbjct: 647 A----TDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 954 RDDDSGNNGVILFSIL 969
D D+G N + ++I+
Sbjct: 703 VDVDTGMNAELKYTIV 718
Score = 150 bits (380), Expect = 6e-36
Identities = 159/621 (25%), Positives = 263/621 (42%), Gaps = 71/621 (11%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNA--- 67
+ VS + P F V +PE+ PVG L A D D N + Y A
Sbjct: 240 VTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPAT 299
Query: 68 -YFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVI-VEDRNDNAPVFQ 125
FA+ TG + + +LD E KVT+ SD R + I V D NDN P
Sbjct: 300 KRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNID 359
Query: 126 NTAFSTSINETL------PVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI 179
+ IN T+ PV + + + DKD G V+ IE+ +P HL +
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF-----HLKAV 414
Query: 180 LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDP 239
N ++ SL + + ++ A D G N + + + + D+ D P
Sbjct: 415 YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-------VRVKLEDENDNPP 467
Query: 240 QFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV 299
F + SV+E+ +G + T+ A D D G N ++Y + + +FD+ R
Sbjct: 468 IFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA--SFFDLD-----RK 520
Query: 300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
G L ++ + +E+ + T T +++ ++ VTV +D ND+ P+F
Sbjct: 521 TGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV--LDENDNSPKF------ 572
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
+F +V E+ + +T V D D G N LS+ D + F +
Sbjct: 573 --------THNHFQFFVSENLPKYSTVGVIT--VTDADAGENKAVTLSILN-DNDNFVLD 621
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ-NFSVAMVTIHLRDINDHRP 478
P +++ + D E+Q++ V ATD S A VTI++ D+ND+ P
Sbjct: 622 PYSG--------VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSP 673
Query: 479 TF---PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVS 535
P + VP + GSVV + + A D DTG ++ Y+++ GN LF++DPV+
Sbjct: 674 VVISPPSNTSFKLVPLSAIPGSVVAE-VFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
Query: 536 GTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQ 595
G +T+ E ++ L + +D G S TL + L +ND A S Y++ +
Sbjct: 733 GNITLE--EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRR 790
Query: 596 EEE----GNVSVTIQAHDNDE 612
E N+ + Q + N++
Sbjct: 791 TMETPLDRNIGDSSQPYQNED 811
Score = 129 bits (324), Expect = 2e-29
Identities = 184/745 (24%), Positives = 297/745 (39%), Gaps = 100/745 (13%)
Query: 135 ETLPVGSVV--FSVLAVDKDMGSAGMVVYSIE---------KVIPSTGDSEHLFRILANG 183
E +P+G++ ++ ++ G++ +VY + KV STG+ +
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 184 SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243
+ S + N+ F++LE+ + ++ F + + + I V D D P F
Sbjct: 96 KLCAGASYAEENE-CFFELEVVI-----LPNDFFRL-----IKIKIIVKDTNDNAPMFPS 144
Query: 244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI--GADGV----I 297
+ S+ E+ + A D D G N Y + DI +G +
Sbjct: 145 PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
V +LDREQ +++++ T Q++ +I + V V DVND++P F
Sbjct: 205 IVQQNLDREQKDTYVMKIKVEDGGTP-------QKSSTAI-LQVTVSDVNDNRPVFKEGQ 256
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+ PE A V T + HA+ D D GSN G A A
Sbjct: 257 VEV--HIPENAPVG-TSVIQLHAT-------------DADIGSNAEIRYIFGAQVAPA-- 298
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHR 477
+R + L+ V +D E V V+A+D S + A VTI++ D+ND+
Sbjct: 299 --TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDG-SSTPARATVTINVTDVNDNP 355
Query: 478 PTFPQSLYVLTVPEHSATGSVVTDSIHA-------TDPDTGAWGQITYSLLPGNGADLFQ 530
P L + P + D ++ +D DT G++ + L
Sbjct: 356 PNI--DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKA 413
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
V + LLD E + + A+D G +L+ + +++ L D NDN P+ +
Sbjct: 414 V--YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
Query: 589 ---SYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
++ G TI A D D N+ +++ L GP + F LD TG+L
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSG--KNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
DRE + R + TV D G P L ++ V +TV D NDN P F + + F V
Sbjct: 528 RVFDREE-----QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 706 EEDPGV-LVGVVKAWDADQTEANNRISFSLSGSGANYFM--IRGLVLGAGWAEGYLRLPP 762
E P VGV+ DAD E N ++ S+ N+ + G++
Sbjct: 583 ENLPKYSTVGVITVTDADAGE-NKAVTLSILNDNDNFVLDPYSGVI------------KS 629
Query: 763 DVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP-TLDVASLRGIRVAEN 821
+VS D E Q + V A + + V +NV DVNDN P + S ++
Sbjct: 630 NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPL 689
Query: 822 GSQHGQ-VAVVVASDVDTSAQLEIQ 845
+ G VA V A DVDT E++
Sbjct: 690 SAIPGSVVAEVFAVDVDTGMNAELK 714
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 177 bits (449), Expect = 6e-44
Identities = 203/751 (27%), Positives = 310/751 (41%), Gaps = 97/751 (12%)
Query: 35 LPEDLPVG------------------AQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKT 76
LPE++P+G A + + + PL +S F + +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVK-VSSSTGEIFTTSNRI 92
Query: 77 GEVKLASALDY----ETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTS 132
KL + Y E + +V I +D + ++ + +IV+D NDNAP+F + + S
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIK--IKIIVKDTNDNAPMFPSPVINIS 150
Query: 133 INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN------GSIV 186
I E + S A D D G G+ Y + G S I+ ++
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYEL-----LNGQSVFGLDIVETPEGEKWPQLI 205
Query: 187 LNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFY 246
+ +L K Y +++K D G T Q S L ++V D D P F
Sbjct: 206 VQQNLDREQKDT-YVMKIKVEDGG-------TPQKSSTAILQVTVSDVNDNRPVFKEGQV 257
Query: 247 SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA----DGVIRVNGS 302
+ E+A GTSV+ + A D D G N + Y P + A G+I V S
Sbjct: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS 317
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LDRE+ A +V T L G VT+ V DVND+ P N L
Sbjct: 318 LDREE--TAIHKV--------TVLASDGSSTPARATVTINVTDVNDNPP---NIDLRYII 364
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
+ +N T Y+ E I +T V D D NG + + + E P
Sbjct: 365 -----SPINGTVYLSEKDPVNTKIALIT--VSDKDTDVNGKVICFI---EREV----PFH 410
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFP 481
Q L+ S+L+DYE + ++VA+DS + + A+V + L D ND+ P F
Sbjct: 411 LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
Q + L+V E++ G +T +I ATD D+G I Y L G A F +D +G +T
Sbjct: 471 QPVIELSVSENNRRGLYLT-TISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTA- 526
Query: 542 NGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEE 598
+ DRE Q + T+ A D G L S + + +LD NDN+P + FV E
Sbjct: 527 -SRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 599 GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
S D N + ++L + NF LDP +G++++ DRE +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILND--NDNFVLDPYSGVIKSNVSFDREQ-----Q 638
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDPGVLVG 714
V +D G+P + VTI V D+NDN P+ + +S+ PG +V
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
Query: 715 VVKAWDADQTEANNRISFSL-SGSGANYFMI 744
V A D D T N + +++ SG+ F I
Sbjct: 699 EVFAVDVD-TGMNAELKYTIVSGNNKGLFRI 728
Score = 164 bits (416), Expect = 4e-40
Identities = 190/736 (25%), Positives = 310/736 (42%), Gaps = 89/736 (12%)
Query: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEAD 312
+AA GTS V + G D + +S ST + + +DRE+L
Sbjct: 53 NAATGTSASLVYRLVSKAG--DAPLVKVSSSTGE---------IFTTSNRIDREKLCAGA 101
Query: 313 EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFT-PEEAQVN 371
+ E + I + I + + V D ND+ P F + P + PE +N
Sbjct: 102 SYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS---PVINISIPENTLIN 158
Query: 372 FTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQV 431
R PI T DPD G NG L + E G Q+
Sbjct: 159 ----------SRFPIPSAT----DPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
Query: 432 LVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVP 490
+V+ + +D E++ +++ D Q S A++ + + D+ND+RP F + + +P
Sbjct: 205 IVQQN--LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 491 EHSATGSVVTDSIHATDPDTGAWGQITY----SLLPGNGADLFQVDPVSGTVTVRNGELL 546
E++ G+ V +HATD D G+ +I Y + P LF ++ +G +TV+ L
Sbjct: 263 ENAPVGTSVIQ-LHATDADIGSNAEIRYIFGAQVAPATKR-LFALNNTTGLITVQRS--L 318
Query: 547 DRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-------NIFVQEEEG 599
DRE A++ +T+ A+DG + + T+ I++ D+NDN P + Y +++ E++
Sbjct: 319 DREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 600 -NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALE 658
N + + + + N + F P+ H ++ + LL LD E
Sbjct: 379 VNTKIALITVSDKDTDVNGKVICFIEREVPF-HLKAVYDNQYLLETSSLLDYEGTK---- 433
Query: 659 GRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVK 717
++ SD G+P L V + +ED NDN PIFNQ +V E + G+ + +
Sbjct: 434 -EFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTIS 492
Query: 718 AWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVFN 775
A D D + N I + L G A++F + + VL A D E Q F
Sbjct: 493 ATDEDSGK-NADIVYQL-GPNASFFDLDRKTGVLTASRV-----------FDREEQERFI 539
Query: 776 LTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASD 835
TV+A + ++ V V V D NDN P + V+EN ++ V V+ +D
Sbjct: 540 FTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF-VSENLPKYSTVGVITVTD 598
Query: 836 VDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVR 895
D + L +IL V S I + + D E T V+
Sbjct: 599 ADAGENKAVTL-SILNDNDNF-----------VLDPYSGVIKSNVSFDREQQSSYTFDVK 646
Query: 896 ACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL--PENKTFVIIPELVLPNREVASVRA 953
A TD G S+ + I + DVNDN+P + P N +F ++P +P VA V A
Sbjct: 647 A----TDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 954 RDDDSGNNGVILFSIL 969
D D+G N + ++I+
Sbjct: 703 VDVDTGMNAELKYTIV 718
Score = 150 bits (380), Expect = 6e-36
Identities = 159/621 (25%), Positives = 263/621 (42%), Gaps = 71/621 (11%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNA--- 67
+ VS + P F V +PE+ PVG L A D D N + Y A
Sbjct: 240 VTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPAT 299
Query: 68 -YFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVI-VEDRNDNAPVFQ 125
FA+ TG + + +LD E KVT+ SD R + I V D NDN P
Sbjct: 300 KRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNID 359
Query: 126 NTAFSTSINETL------PVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI 179
+ IN T+ PV + + + DKD G V+ IE+ +P HL +
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF-----HLKAV 414
Query: 180 LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDP 239
N ++ SL + + ++ A D G N + + + + D+ D P
Sbjct: 415 YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-------VRVKLEDENDNPP 467
Query: 240 QFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV 299
F + SV+E+ +G + T+ A D D G N ++Y + + +FD+ R
Sbjct: 468 IFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA--SFFDLD-----RK 520
Query: 300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
G L ++ + +E+ + T T +++ ++ VTV +D ND+ P+F
Sbjct: 521 TGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV--LDENDNSPKF------ 572
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
+F +V E+ + +T V D D G N LS+ D + F +
Sbjct: 573 --------THNHFQFFVSENLPKYSTVGVIT--VTDADAGENKAVTLSILN-DNDNFVLD 621
Query: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ-NFSVAMVTIHLRDINDHRP 478
P +++ + D E+Q++ V ATD S A VTI++ D+ND+ P
Sbjct: 622 PYSG--------VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSP 673
Query: 479 TF---PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVS 535
P + VP + GSVV + + A D DTG ++ Y+++ GN LF++DPV+
Sbjct: 674 VVISPPSNTSFKLVPLSAIPGSVVAE-VFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
Query: 536 GTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQ 595
G +T+ E ++ L + +D G S TL + L +ND A S Y++ +
Sbjct: 733 GNITLE--EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRR 790
Query: 596 EEE----GNVSVTIQAHDNDE 612
E N+ + Q + N++
Sbjct: 791 TMETPLDRNIGDSSQPYQNED 811
Score = 129 bits (324), Expect = 2e-29
Identities = 184/745 (24%), Positives = 297/745 (39%), Gaps = 100/745 (13%)
Query: 135 ETLPVGSVV--FSVLAVDKDMGSAGMVVYSIE---------KVIPSTGDSEHLFRILANG 183
E +P+G++ ++ ++ G++ +VY + KV STG+ +
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 184 SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243
+ S + N+ F++LE+ + ++ F + + + I V D D P F
Sbjct: 96 KLCAGASYAEENE-CFFELEVVI-----LPNDFFRL-----IKIKIIVKDTNDNAPMFPS 144
Query: 244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI--GADGV----I 297
+ S+ E+ + A D D G N Y + DI +G +
Sbjct: 145 PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
V +LDREQ +++++ T Q++ +I + V V DVND++P F
Sbjct: 205 IVQQNLDREQKDTYVMKIKVEDGGTP-------QKSSTAI-LQVTVSDVNDNRPVFKEGQ 256
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+ PE A V T + HA+ D D GSN G A A
Sbjct: 257 VEV--HIPENAPVG-TSVIQLHAT-------------DADIGSNAEIRYIFGAQVAPA-- 298
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHR 477
+R + L+ V +D E V V+A+D S + A VTI++ D+ND+
Sbjct: 299 --TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDG-SSTPARATVTINVTDVNDNP 355
Query: 478 PTFPQSLYVLTVPEHSATGSVVTDSIHA-------TDPDTGAWGQITYSLLPGNGADLFQ 530
P L + P + D ++ +D DT G++ + L
Sbjct: 356 PNI--DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKA 413
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
V + LLD E + + A+D G +L+ + +++ L D NDN P+ +
Sbjct: 414 V--YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
Query: 589 ---SYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
++ G TI A D D N+ +++ L GP + F LD TG+L
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSG--KNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
DRE + R + TV D G P L ++ V +TV D NDN P F + + F V
Sbjct: 528 RVFDREE-----QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 706 EEDPGV-LVGVVKAWDADQTEANNRISFSLSGSGANYFM--IRGLVLGAGWAEGYLRLPP 762
E P VGV+ DAD E N ++ S+ N+ + G++
Sbjct: 583 ENLPKYSTVGVITVTDADAGE-NKAVTLSILNDNDNFVLDPYSGVI------------KS 629
Query: 763 DVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP-TLDVASLRGIRVAEN 821
+VS D E Q + V A + + V +NV DVNDN P + S ++
Sbjct: 630 NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPL 689
Query: 822 GSQHGQ-VAVVVASDVDTSAQLEIQ 845
+ G VA V A DVDT E++
Sbjct: 690 SAIPGSVVAEVFAVDVDTGMNAELK 714
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 177 bits (449), Expect = 6e-44
Identities = 286/1038 (27%), Positives = 425/1038 (40%), Gaps = 171/1038 (16%)
Query: 14 LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVT 73
L +SV + P L LP F+L +ED D+ PL F V
Sbjct: 69 LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFL-SEDSDDSPLLDD--------FHVH 119
Query: 74 PKTGEVKLASALDYETL--YTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFST 131
P TG ++ A LD E Y+F V ++ +QV+ + V D ND++P F +
Sbjct: 120 PDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQVE----IRVNDVNDHSPRFPLDSLQL 174
Query: 132 SINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLF---RILANGSI--- 185
++E P G+ +A D D G Y++ + D F R G +
Sbjct: 175 DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
Query: 186 VLNGSLSY-------------NNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
+L GS S ++A ++L+++A D GG T + L V+
Sbjct: 235 LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD-GGRPRRTGLLSVEL------RVL 287
Query: 233 DQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG 292
D+ D P F ++ Y A+V EDA G V V A D D G N V YS+ PG G
Sbjct: 288 DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
Query: 293 A-------------DGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKV-SIW 338
GV+RV LDR EA QL V A + G E +V ++
Sbjct: 348 GALGDAAYFAVEELSGVVRVWRPLDR----EAQAWHQLVVEARDG-----GAEPEVATVR 398
Query: 339 VTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASP-----RIPIDDLTMVV 393
V++ V+DVND++P + F E V E A P R+ + D
Sbjct: 399 VSIAVLDVNDNRPAIH------VLFLTEGG----VARVSEGARPGDYVARVSVSDADGDW 448
Query: 394 YDPDKGS--------NGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQT 445
D+ + +G+ LSL G + + F++ P G + V +D E +
Sbjct: 449 EKEDEATGELGVGLGDGSISLSLEGGEGD-FALLP----GGPPGVFFLCVEGPLDRESRD 503
Query: 446 AMAVQVVATDSVSQNFSV-AMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIH 504
+ +VATD+ S S + + + D+ND P F Q Y +V E +A G+VV +
Sbjct: 504 LYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVM-WVS 562
Query: 505 ATDPDTG----AWGQITYSLL--PGNGADL-------------FQVDPVSGTV-TVRNGE 544
A+D D AW + T L P N L F +D SG + T+R
Sbjct: 563 ASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT-- 620
Query: 545 LLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVV-SGSYNIFVQEEE--G 599
LDRE Q L + A D G LS++ + I + D+NDN P+ YN + E G
Sbjct: 621 -LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
Query: 600 NVSVTIQAHDNDEP--GTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
+ + + A D D G L L F +DP G + +DRE DPA
Sbjct: 680 HCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER-DPAT 738
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVV 716
L V D G L + V + +ED+NDN P+FN S+Y ++ +E PG + V
Sbjct: 739 YD---LLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINV 793
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI---RGLVLGAGWAEGYLRLPPDVSLDYETQPV 773
A D D + G+ ++ F I G++ YL LP L +
Sbjct: 794 LATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGII--------YLTLP----LSHLESTT 841
Query: 774 FNLTVSAENPDPQGGETIV---DVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAV 830
+L VSA++ GG T V DV +++ P + + V E+ + +
Sbjct: 842 LSLMVSAQD---GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL-VYEDVPEDSPIGT 897
Query: 831 VVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLV 890
V A + S++ I + D+G G FS+ I K +D+E +V
Sbjct: 898 VKAREPLNSSE------PIFYRISSGDLG----GKFSIHPRLGT-IRTRKPLDHETQPVV 946
Query: 891 TLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVAS 950
L V+A L + P + N IT+ DVNDN P FL + I + P +
Sbjct: 947 VLTVQA-QLGSAPACSSTEVN----ITVMDVNDNHPAFL-RTSDEIRISQTTPPGTALYL 1000
Query: 951 VRARDDDSGNNGVILFSI 968
RA D DSG NG+I +SI
Sbjct: 1001 ARAEDRDSGRNGLIRYSI 1018
Score = 166 bits (421), Expect = 1e-40
Identities = 263/1076 (24%), Positives = 421/1076 (39%), Gaps = 170/1076 (15%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTY-----------------GMSGPN 66
P F + + ED GA+ + A D+D P + G G
Sbjct: 294 PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
Query: 67 AYFFAVTPKTGEVKLASALDYETLYTFKVTISVSD----PYIQVQREMLVIVEDRNDNAP 122
AYF AV +G V++ LD E ++ + D P + R + ++ D NDN P
Sbjct: 354 AYF-AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL-DVNDNRP 411
Query: 123 ----VFQNTAFSTSINETLPVGSVVFSVLAVDKD---------MGSAGMVVYSIEKVIPS 169
+F ++E G V V D D G G V + S
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELG-VGLGDGSISLS 470
Query: 170 TGDSEHLFRILANGS-----IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLP 224
E F +L G + + G L ++ Y+L L A D G S
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRD-LYELLLVATDAGSP-------PLSTE 522
Query: 225 VFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDP--VIYSISY 282
L + V D D P F ++ Y ASV+E AA GT V+ V A D D+ +D + Y++
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 283 STRP-----------------GWFDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATET 324
+ P F I ++ G I +LDRE E V+L+V A +
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDRE----VQEAVELKVVAQD- 637
Query: 325 HLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRI 384
+ + V++ V DVND++P F+ QV + + EHA
Sbjct: 638 ---LGEPPLSATCLVSITVDDVNDNEPIFWR-------------QV-YNATIAEHA---- 676
Query: 385 PIDD--LTMVVYDPDKGSNGTFLLSL-----GGPDAEAFSVSPERAAGSASVQVLVRVSA 437
P+ L + D D G G SL +AF + P + VS
Sbjct: 677 PVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ--------ICVSQ 728
Query: 438 LVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGS 497
+D ER A +V + A V + L D+ND+ P F S YV ++ + + G+
Sbjct: 729 DIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT 788
Query: 498 VVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLT 557
+ + + ATD D+G +G + Y L+PGN + LF +D +G + + L L
Sbjct: 789 EIINVL-ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP--LSHLESTTLSLM 845
Query: 558 LQATDGGNLSS--STTLQIHLLDIN-DNAPVVSGSYNIFVQEE--EGNVSVTIQAHDNDE 612
+ A DGG L++ + + IH+ A Y V E+ E + T++A E
Sbjct: 846 VSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR---E 902
Query: 613 PGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE 672
P ++ + + + G FS+ P G +R PLD E + +VLTV + G
Sbjct: 903 PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET-----QPVVVLTVQ-AQLGS 956
Query: 673 PVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRIS 731
+ V ITV D+NDN P F ++S + + P G + + +A D D N I
Sbjct: 957 APACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR-NGLIR 1015
Query: 732 FSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETI 791
+S++ F I LG + G SL Q LT+ AE+ +
Sbjct: 1016 YSIASPQPGVFAI-DRALGVLFLNG--------SLGAGEQRELTLTLRAEDQGVHPQAAL 1066
Query: 792 VDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILC 851
+ + V ++ +P + + V+E+ S Q+ A + + + L
Sbjct: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQ-----RAASPLR 1121
Query: 852 TKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNN 911
V S +G G +Y+ + DYE+ V A + D Q S
Sbjct: 1122 YSLEPSVDSAMFGIRPYT--GWIYLRRQ--FDYESTQTYNFRVFAW-IPEDGFLQNVST- 1175
Query: 912 GSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRV 971
++++ + D NDN+P FL + F+ + E +P + + A D DSG NG +L+
Sbjct: 1176 -TVIVRVWDENDNSPTFL-HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY----- 1228
Query: 972 DFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPS 1027
F+ DG + + G + +LD +G +++TV DR S
Sbjct: 1229 -FLLSDGKFF------------KMNPNTGELINWVALDREHRGHHEMTVLVTDRGS 1271
Score = 159 bits (403), Expect = 1e-38
Identities = 213/763 (27%), Positives = 326/763 (42%), Gaps = 96/763 (12%)
Query: 6 LSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGP 65
LS L ++ V + P F + + + E PVG + A D D+ YG
Sbjct: 643 LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG--LYGFIEY 700
Query: 66 NAY----------FFAVTPKTGEVKLASALDYET-LYTFKVTISVSDPY-IQVQREMLVI 113
+ Y F + P G++ ++ +D E T+ + + D + Q + V
Sbjct: 701 SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVD 760
Query: 114 VEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDS 173
+ED NDN PVF + + TSI++ G+ + +VLA D+D G G V Y ++IP G+
Sbjct: 761 LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY---ELIP--GNV 815
Query: 174 EHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
LF I G I L LS+ +S L + A D GG+ T I + + +
Sbjct: 816 SSLFTIDSTTGIIYLTLPLSH-LESTTLSLMVSAQDGGGL---TAVINADVTIH-----I 866
Query: 233 DQPDLDP-QFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI 291
Q L P +F R Y+ V ED + + + TV+A + ++P+ Y IS G F I
Sbjct: 867 FQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSI 925
Query: 292 GAD-GVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHK 350
G IR LD E VQ Q+ + A S V + VMDVND+
Sbjct: 926 HPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA---------PACSSTEVNITVMDVNDNH 976
Query: 351 PEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMV-VYDPDKGSNGTFLLSLG 409
P F T +E +++ T +P P L + D D G NG S+
Sbjct: 977 PAFLR--------TSDEIRISQT-------TP--PGTALYLARAEDRDSGRNGLIRYSIA 1019
Query: 410 GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIH 469
P F++ +RA G ++ ++ + Q + + + A D + +V
Sbjct: 1020 SPQPGVFAI--DRALG------VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 1071
Query: 470 LRDINDHRP--TFPQSLYVLTVPEH-SATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA 526
+ + +H P TF +Y + V E S ++ H P A + YSL P +
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA-SPLRYSLEPSVDS 1130
Query: 527 DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQA---TDGGNLSSSTTLQIHLLDINDNA 583
+F + P +G + +R D ES Y + A DG + STT+ + + D NDN+
Sbjct: 1131 AMFGIRPYTGWIYLR--RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
Query: 584 PVVSGSYNIFVQEEEG----NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDT 639
P +F++ EE V I A D D G N L F L G + F ++P+T
Sbjct: 1189 PTFLHDV-LFLKVEESPVPQGVIGKITAIDMDS-GKNGQLLYFLLSDGKF---FKMNPNT 1243
Query: 640 GLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQ-- 697
G L N LDRE G +TVLV+D G P + V ++V DINDN P F Q
Sbjct: 1244 GELINWVALDREH-----RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCL 1298
Query: 698 --SSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGS 737
+ V E P +LV V A D D+ N +++S+S +
Sbjct: 1299 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGN-NAEVTYSVSSA 1340
Score = 152 bits (385), Expect = 2e-36
Identities = 238/944 (25%), Positives = 378/944 (40%), Gaps = 129/944 (13%)
Query: 64 GPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPV 123
GP FF G + S YE L V P + + +L+ V D ND P+
Sbjct: 484 GPPGVFFLCVE--GPLDRESRDLYELLL---VATDAGSPPLSTEETLLLRVADLNDQPPL 538
Query: 124 FQNTAFSTSINETLPVGSVVFSVLAVDKDMG--------------SAGMVVYSIEKVIPS 169
F + S++E G+VV V A D D SA + S++ +
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
Query: 170 TGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLS 228
T + F I +G+I +L + A +L++ A DLG S +S
Sbjct: 599 TAECGPSFAIDSESGAISTIRTLDREVQEA-VELKVVAQDLG-------EPPLSATCLVS 650
Query: 229 ISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS-----ISYS 283
I+V D D +P F R+ Y+A++AE A G L V A D D G+ + YS +SY
Sbjct: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
Query: 284 TRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRV 343
+ DG I V+ +DRE+ L V A + G +V V +
Sbjct: 711 APQAFRIDPHDGQICVSQDIDRER---DPATYDLLVEAKD------GGGLSAQAFVRVDL 761
Query: 344 MDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGT 403
DVND+ P F P + + + P I + ++ D D G GT
Sbjct: 762 EDVNDNHP----------VFNPS----TYVTSISDETQPGTEI--INVLATDQDSGIYGT 805
Query: 404 FLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
L G + F++ S ++ ++ + + T +++ V A D
Sbjct: 806 VAYELIPGNVSSLFTID--------STTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAV 857
Query: 463 V-AMVTIH-----LRDINDHRPTFPQSLYVLTVPEHSATGSV-VTDSIHATDPDTGAWGQ 515
+ A VTIH L RP + +Y VPE S G+V + +++++P
Sbjct: 858 INADVTIHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGTVKAREPLNSSEP------- 909
Query: 516 ITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDG-GNLSSSTTLQI 574
I Y + G+ F + P GT+ R + LD E+Q V LT+QA G SST + I
Sbjct: 910 IFYRISSGDLGGKFSIHPRLGTIRTR--KPLDHETQPVVVLTVQAQLGSAPACSSTEVNI 967
Query: 575 HLLDINDNAPV---VSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSH 631
++D+NDN P S I G +A D D + + L+ + P
Sbjct: 968 TVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD---SGRNGLIRYSIASPQPG 1024
Query: 632 NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDN 691
F++D G+L G ++ + + LT+ D G + +T+ +E ++
Sbjct: 1025 VFAIDRALGVLFLNG-----SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REH 1078
Query: 692 LP--IFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
P F Y V E P + +A A + + +SL S + G+
Sbjct: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMF--GIR 1136
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETI-VDVCVNVKDVNDNPPT 807
GW YLR DYE+ +N V A P+ + + V V V D NDN PT
Sbjct: 1137 PYTGWI--YLRR----QFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 1190
Query: 808 LDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFS 867
+ + ++V E+ G + + A D+D+ QL+ L + +F
Sbjct: 1191 F-LHDVLFLKVEESPVPQGVIGKITAIDMDSGK--NGQLLYFLLSDG---------KFFK 1238
Query: 868 VAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPY 927
+ N IN A+D E + V L TD G + ++ +++ D+NDN P+
Sbjct: 1239 MNPNTGELINW-VALDREHRGHHEMTV----LVTDRGSPPRNATMAVYVSVTDINDNRPF 1293
Query: 928 F---LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
F LP + V + E N V +V A+D D GNN + +S+
Sbjct: 1294 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 116 bits (290), Expect = 2e-25
Identities = 181/672 (26%), Positives = 264/672 (39%), Gaps = 111/672 (16%)
Query: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDA---EAFSVSPERAAGSA 427
N T VDE P + D+ + + F LS D+ + F V P+
Sbjct: 68 NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTG---- 123
Query: 428 SVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVL 487
++R + +D ER+ + VA + +V V I + D+NDH P FP L
Sbjct: 124 ----IIRTARRLDRERRDHYSF--VAATLLG---AVVQVEIRVNDVNDHSPRFPLDSLQL 174
Query: 488 TVPEHSATGSVVTDSIHATDPDTGAW-----------------------------GQITY 518
V E S G+ + A DPD G + G +
Sbjct: 175 DVSELSPPGTAFRLPV-AHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPS 233
Query: 519 SLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL-- 576
LLPG+ + L +D V +R LDRE A + L ++A DGG + L + L
Sbjct: 234 PLLPGSSSPLEPLD----LVLLRR---LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
Query: 577 LDINDNAPVV-SGSYNIFVQE--EEGNVSVTIQAHDND--EPGTNNSRLLFNLLPGPYSH 631
LD NDN PV Y V+E + G ++A D D G + +PG S
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
Query: 632 N--------FSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCG-EPVLGTKVNVT 682
F+++ +G++R PLDREA + L V D G EP + T V V+
Sbjct: 347 GGALGDAAYFAVEELSGVVRVWRPLDREA-----QAWHQLVVEARDGGAEPEVAT-VRVS 400
Query: 683 ITVEDINDNLP-----IFNQSSYNFTVKEEDPGVLVGVVKAWDAD-----QTEANNRISF 732
I V D+NDN P + + PG V V DAD + EA +
Sbjct: 401 IAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV 460
Query: 733 SLSGSGANYFMIRG----LVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGG 788
L G G+ + G L G G L + LD E++ ++ L + A +
Sbjct: 461 GL-GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
Query: 789 ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQL-V 847
T + + V D+ND PP + V+E + V V ASD D + L
Sbjct: 520 STEETLLLRVADLNDQPPLFSQQHYKA-SVSEAAAPGTVVMWVSASDADEAGSDHAWLRY 578
Query: 848 NILCTKAGVDVGSL---------CWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACD 898
++ A ++GSL C F++ + I+ + +D E + V L V A D
Sbjct: 579 TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA-ISTIRTLDREVQEAVELKVVAQD 637
Query: 899 LATDPGFQAYSNNGSLLITIEDVNDNAPYFLPE--NKTFVIIPELVLPNREVASVRARDD 956
L P S + IT++DVNDN P F + N T I E V A D
Sbjct: 638 LGEPP----LSATCLVSITVDDVNDNEPIFWRQVYNAT---IAEHAPVGHCFLQVTASDA 690
Query: 957 DSGNNGVILFSI 968
DSG G I +S+
Sbjct: 691 DSGLYGFIEYSL 702
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/577 (27%), Positives = 240/577 (41%), Gaps = 95/577 (16%)
Query: 527 DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP-- 584
D F V P +G + R LDRE + +Y + AT L + ++I + D+ND++P
Sbjct: 114 DDFHVHPDTGII--RTARRLDRERRD-HYSFVAAT---LLGAVVQVEIRVNDVNDHSPRF 167
Query: 585 -VVSGSYNIFVQEEEGNVSVTIQAHDND-------------------EPGTNNSRLLFN- 623
+ S ++ G AHD D +P +L +
Sbjct: 168 PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
Query: 624 -------LLPGPYSHNFSLDP-DTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL 675
LLPG S L+P D LLR L DRE A R L + D G P
Sbjct: 228 PGPLPSPLLPGSSS---PLEPLDLVLLRRL---DREE---AAAHR--LQIEAWDGGRPRR 276
Query: 676 GTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSL 734
++V + V D NDN P+F Q Y V+E+ PG V V+A D D N + +S+
Sbjct: 277 TGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRD-LGPNGFVRYSV 335
Query: 735 -------SGSG------ANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAE 781
+GSG A YF + L G +R+ LD E Q L V A
Sbjct: 336 RARQVPGAGSGGGALGDAAYFAVEEL-------SGVVRVWRP--LDREAQAWHQLVVEAR 386
Query: 782 NPDPQGGETIVDVCVNVKDVNDNPPTLDVASLR--GI-RVAENGSQHGQVAVVVASDVDT 838
+ + V V + V DVNDN P + V L G+ RV+E VA V SD D
Sbjct: 387 DGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADG 446
Query: 839 SAQLEIQLVNILCTKAGVDVGSLCW----GWFSVAANGS---VYINQSKAIDYEACDLVT 891
+ E + L G SL G F++ G ++ +D E+ DL
Sbjct: 447 DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE 506
Query: 892 LVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASV 951
L++ +ATD G S +LL+ + D+ND P F ++ + E P V V
Sbjct: 507 LLL----VATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYK-ASVSEAAAPGTVVMWV 561
Query: 952 RARD-DDSGNNGVIL-FSILRVDFISKDGAT-IPFQGVFSIFTSSEADVFAGSIQPVTSL 1008
A D D++G++ L ++++++ G+ S D +G+I + +L
Sbjct: 562 SASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL 621
Query: 1009 DSTLQGTYQVTVQARDRPSLG-PFLEATTTLNLFTVD 1044
D +Q ++ V A+D LG P L AT +++ TVD
Sbjct: 622 DREVQEAVELKVVAQD---LGEPPLSATCLVSI-TVD 654
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 7/107 (6%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQ 125
FF + P TGE+ ALD E ++T+ V+D P + V V D NDN P F
Sbjct: 1236 FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 1295
Query: 126 NTA----FSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIP 168
+ E PV +V +V A D D G+ V YS+ P
Sbjct: 1296 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
>gi|14589929 protocadherin 18 precursor [Homo sapiens]
Length = 1135
Score = 174 bits (441), Expect = 5e-43
Identities = 175/648 (27%), Positives = 292/648 (45%), Gaps = 76/648 (11%)
Query: 62 MSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREML------VIVE 115
M N+ V GE+ + + +D E L + S+ I + E L V V
Sbjct: 69 MQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVL 128
Query: 116 DRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
D NDN+P F + I+E+ VG+ + A D D+G + YS+ S D +
Sbjct: 129 DINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSL-----SANDFFN 183
Query: 176 L-FRILANGS----IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSIS 230
+ R +G+ +++ L KS+ Y+L+L A D+G + +I L IS
Sbjct: 184 IEVRTRTDGAKYAELIVVRELDRELKSS-YELQLTASDMGVPQRSGSSI-------LKIS 235
Query: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFD 290
+ D D P F ++ Y + E++ GT +L + A D D+G N ++YS S P +
Sbjct: 236 ISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIME 295
Query: 291 IGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHK 350
R + +L ++ E + ++ V A + N K+ I +V+DVND+K
Sbjct: 296 TFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIII----KVVDVNDNK 351
Query: 351 PEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVV--YDPDKGSNGTFLLSL 408
PE N +L +P + ++++ D PID +V D D G NG + L
Sbjct: 352 PEI-NINL----MSPGKEEISYIFEGD-------PIDTFVALVRVQDKDSGLNGEIVCKL 399
Query: 409 GGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVT 467
G + E L+ +A +D E+++ ++ V+A D + + S V T
Sbjct: 400 HGHGHFKLQKTYEN-------NYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFT 452
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLP----G 523
+ + DIND+ P F +S Y + E+++ G+ +T ++ ATDPD G GQ+TY++L G
Sbjct: 453 VQINDINDNPPHFQRSRYEFVISENNSPGAYIT-TVTATDPDLGENGQVTYTILESFILG 511
Query: 524 NGADLF-QVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDI 579
+ + +DP +G + + D E + ++A DGG+ L S+TT+ + ++D
Sbjct: 512 SSITTYVTIDPSNGAIYALR--IFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDE 569
Query: 580 NDNAPVVSG--------SYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSH 631
NDN PVV G I E G I+A D D N+ L ++ G +
Sbjct: 570 NDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGV--NAELSCAIVAGNEEN 627
Query: 632 NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKV 679
F +DP R+ ++D L+V++ D G P L TKV
Sbjct: 628 IFIIDP-----RSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKV 670
Score = 148 bits (374), Expect = 3e-35
Identities = 156/587 (26%), Positives = 257/587 (43%), Gaps = 89/587 (15%)
Query: 294 DGVIRVNGSLDREQLLEADEEVQLQ---VTATETHLNIYGQEAKVSIWVTVRVMDVNDHK 350
+G I + ++DREQL + + ++ +T HL ++ E V V+D+ND+
Sbjct: 83 NGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIE--------VEVLDINDNS 134
Query: 351 PEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGG 410
P+F +P E A V RIP+D +DPD G N SL
Sbjct: 135 PQFSRSLIPI--EISESAAVG----------TRIPLDS----AFDPDVGENSLHTYSLSA 178
Query: 411 PDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAMVTIH 469
D F++ A L+ V L D E +++ +Q+ A+D V Q +++ I
Sbjct: 179 NDF--FNIEVRTRTDGAKYAELIVVREL-DRELKSSYELQLTASDMGVPQRSGSSILKIS 235
Query: 470 LRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSL---LPGNGA 526
+ D ND+ P F Q Y++ + E+S G+++ D ++ATDPD GA G+I YS +
Sbjct: 236 ISDSNDNSPAFEQQSYIIQLLENSPVGTLLLD-LNATDPDEGANGKIVYSFSSHVSPKIM 294
Query: 527 DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAP 584
+ F++D G +T+ + +D E Y + +QA D G ++ + + I ++D+NDN P
Sbjct: 295 ETFKIDSERGHLTLF--KQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKP 352
Query: 585 VVSGSYNIFVQEE-----EGNVSVTIQA--HDNDEPGTNNSRLLFNL-------LPGPYS 630
++ + +EE EG+ T A D+ N ++ L L Y
Sbjct: 353 EININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYE 412
Query: 631 HNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIND 690
+N+ L+ LDRE LTV+ D G P L T + T+ + DIND
Sbjct: 413 NNY-------LILTNATLDREK-----RSEYSLTVIAEDRGTPSLSTVKHFTVQINDIND 460
Query: 691 NLPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVL 749
N P F +S Y F + E + PG + V A D D E N +++ Y ++ +L
Sbjct: 461 NPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGE-NGQVT---------YTILESFIL 510
Query: 750 GAGWAEGYLRLPPDVSLDY-----ETQPVFNLTVSAENPDPQGGETIVD---VCVNVKDV 801
G+ Y+ + P Y + + V +T E D + +V V + + D
Sbjct: 511 GSS-ITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDE 569
Query: 802 NDNPPTLDVASLRG----IRVAENGSQHGQVAVVVASDVDTSAQLEI 844
NDN P + +LR I + + V + A D D+ E+
Sbjct: 570 NDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAEL 616
Score = 136 bits (342), Expect = 2e-31
Identities = 151/539 (28%), Positives = 239/539 (44%), Gaps = 59/539 (10%)
Query: 458 SQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGS-VVTDSIHATDPDTGAWGQI 516
+++ + + + + DIND+ P F +SL + + E +A G+ + DS A DPD G
Sbjct: 115 TEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDS--AFDPDVGENSLH 172
Query: 517 TYSLLPGNGADLFQVDPVSGTVTVRNGEL-----LDRESQAVYYLTLQATDGG--NLSSS 569
TYSL + D F ++ + T + EL LDRE ++ Y L L A+D G S S
Sbjct: 173 TYSL---SANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGS 229
Query: 570 TTLQIHLLDINDNAPVVSG-SYNIFVQEEE--GNVSVTIQAHDNDEPGTNNSRLLFNLLP 626
+ L+I + D NDN+P SY I + E G + + + A D DE F+
Sbjct: 230 SILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHV 289
Query: 627 GP-YSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITV 685
P F +D + G L +D E I + E + V D G + + I V
Sbjct: 290 SPKIMETFKIDSERGHLTLFKQVDYE-ITKSYE----IDVQAQDLGPNSIPAHCKIIIKV 344
Query: 686 EDINDNLPIFN---------QSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLS 735
D+NDN P N + SY F E DP V +V+ D D + N I L
Sbjct: 345 VDVNDNKPEININLMSPGKEEISYIF---EGDPIDTFVALVRVQDKD-SGLNGEIVCKLH 400
Query: 736 GSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVC 795
G G +F ++ + YL L + +LD E + ++LTV AE+ T+
Sbjct: 401 GHG--HFKLQKT-----YENNYLILT-NATLDREKRSEYSLTVIAEDRGTPSLSTVKHFT 452
Query: 796 VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAG 855
V + D+NDNPP + + ++EN S + V A+D D ++ +
Sbjct: 453 VQINDINDNPPHFQRSRYEFV-ISENNSPGAYITTVTATDPDLGENGQVTYTIL----ES 507
Query: 856 VDVGSLCWGWFSV-AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSL 914
+GS + ++ +NG++Y + D+E +T VV A D + + +N ++
Sbjct: 508 FILGSSITTYVTIDPSNGAIYA--LRIFDHEEVSQITFVVEARDGGSP---KQLVSNTTV 562
Query: 915 LITIEDVNDNAPYF----LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSIL 969
++TI D NDN P L N + IP+ V +RA D DSG N + +I+
Sbjct: 563 VLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIV 621
Score = 108 bits (269), Expect = 4e-23
Identities = 150/636 (23%), Positives = 264/636 (41%), Gaps = 87/636 (13%)
Query: 6 LSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM 62
L F + V+ + N +P+F ++ + + E VG + A D D N TY +
Sbjct: 118 LQLFHIEVEVLDINDN-SPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSL 176
Query: 63 SGPNAYFFAVTPKTGEVKLASA-----LDYETLYTFKVTISVSD---PYIQVQREMLVIV 114
S + + V +T K A LD E ++++ ++ SD P + + +
Sbjct: 177 SANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISI 236
Query: 115 EDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEK-VIPSTGDS 173
D NDN+P F+ ++ + E PVG+++ + A D D G+ G +VYS V P ++
Sbjct: 237 SDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMET 296
Query: 174 EHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
F+I G + L + Y + Y+++++A DLG N+ C + I VV
Sbjct: 297 ---FKIDSERGHLTLFKQVDYEITKS-YEIDVQAQDLG---PNSIPAHCK----IIIKVV 345
Query: 233 DQPDLDPQFVREFYS------ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRP 286
D D P+ S + + E T V V D D G+N ++ +
Sbjct: 346 DVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLH---GH 402
Query: 287 GWFDIGA----DGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVR 342
G F + + +I N +LDRE+ E V + T + + TV+
Sbjct: 403 GHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVK--------HFTVQ 454
Query: 343 VMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG 402
+ D+ND+ P F + ++ F + E+ SP I T+ DPD G NG
Sbjct: 455 INDINDNPPHF------------QRSRYEFV--ISENNSPGAYI--TTVTATDPDLGENG 498
Query: 403 ----TFLLS--LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS 456
T L S LG ++ P A + + D+E + + V A D
Sbjct: 499 QVTYTILESFILGSSITTYVTIDPSNGA--------IYALRIFDHEEVSQITFVVEARDG 550
Query: 457 VSQNFSVAMVTIHLRDINDH-------RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPD 509
S V+ T+ L I+++ P + +T+P+ + +G VT I A D D
Sbjct: 551 GSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVT-RIRAIDRD 609
Query: 510 TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSS 569
+G +++ +++ GN ++F +DP S + +D + L++ D GN
Sbjct: 610 SGVNAELSCAIVAGNEENIFIIDPRS--CDIHTNVSMDSVPYTEWELSVIIQDKGNPQLH 667
Query: 570 TTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTI 605
T + + + I + A V+ + V + +VS+ I
Sbjct: 668 TKVLLKCM-IFEYAESVTSTAMTSVSQASLDVSMII 702
Score = 100 bits (249), Expect = 9e-21
Identities = 171/742 (23%), Positives = 282/742 (38%), Gaps = 109/742 (14%)
Query: 572 LQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSH 631
+++ +LDINDN+P S S E V I +P + L L
Sbjct: 123 IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFF 182
Query: 632 NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDN 691
N + T + + +D L+ L + SD G P + I++ D NDN
Sbjct: 183 NIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDN 242
Query: 692 LPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLG 750
P F Q SY + E P G L+ + A D D+ AN +I +S S + M +
Sbjct: 243 SPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEG-ANGKIVYSFSSHVSPKIMETFKIDS 301
Query: 751 AGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDV 810
G+L L V DYE + + V A++ P + + V DVNDN P ++
Sbjct: 302 E---RGHLTLFKQV--DYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEIN- 355
Query: 811 ASLRGIRVAENGSQHGQVAVVVASD-VDTSAQLEIQLVNILCTKAGVDVGSLC----WGW 865
I + G + +++ + D +DT + LV + +G++ +C G
Sbjct: 356 -----INLMSPGKE--EISYIFEGDPIDTF----VALVRVQDKDSGLNGEIVCKLHGHGH 404
Query: 866 FSVAAN--GSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVND 923
F + + I + +D E +L V +A D G + S + I D+ND
Sbjct: 405 FKLQKTYENNYLILTNATLDREKRSEYSLTV----IAEDRGTPSLSTVKHFTVQINDIND 460
Query: 924 NAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPF 983
N P+F FV I E P + +V A D D G NG + ++IL +
Sbjct: 461 NPPHFQRSRYEFV-ISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGS------- 512
Query: 984 QGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTV 1043
SI T D G+I + D V+ARD S L + TT+ L +
Sbjct: 513 ----SITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGS-PKQLVSNTTVVLTII 567
Query: 1044 DQS-----------YRSRLQFSTPK---------------EEVGANRQAINAALTQATRT 1077
D++ + + + PK + G N + ++ A+
Sbjct: 568 DENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAE-LSCAIVAGNEE 626
Query: 1078 TVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRN-DQDSLTQLLQLGLV 1136
++I+D + D V + T ELSV+I++ L + L +
Sbjct: 627 NIFIIDPRSCDIHTN-----------VSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCM 675
Query: 1137 VLGSQES---------QESDLSKQLISVIIGLGVALLLVLVIMTM-AFVCVR-----KSY 1181
+ ES ++ L +I +II LG ++LVIM + A C R +SY
Sbjct: 676 IFEYAESVTSTAMTSVSQASLDVSMI-IIISLGAICAVLLVIMVLFATRCNREKKDTRSY 734
Query: 1182 NRKLQAM----KAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSP 1237
N ++ + +R+ G + P I GT + + + P + G
Sbjct: 735 NCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQ 794
Query: 1238 S-------NDLDSVSVNSLDDN 1252
S N L ++S N + +N
Sbjct: 795 SHNSHQSLNSLVTISSNHVPEN 816
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 172 bits (437), Expect = 1e-42
Identities = 187/687 (27%), Positives = 298/687 (43%), Gaps = 74/687 (10%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F + KL + + + ++V +++ I ++ ++ED NDNAP+F T
Sbjct: 85 FTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVI 144
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----LANG-- 183
+ SI E + S AVD D+G G+ Y + K S+++F + G
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-------SQNIFGLDVIETPEGDK 197
Query: 184 --SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF 241
+++ L K Y +++K D GG + T L +SV D D P F
Sbjct: 198 MPQLIVQKELDREEKDT-YVMKVKVED-GGFPQRSST------AILQVSVTDTNDNHPVF 249
Query: 242 VREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS----ISYSTRPGWFDIGADGVI 297
S+ E+A GTSV + A D D G N + +S +S R + G+I
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
+ LDRE+ +L V A++ G V V V DVND +
Sbjct: 310 TIKEPLDREE----TPNHKLLVLASD------GGLMPARAMVLVNVTDVND--------N 351
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+P+ VN T + E+ I +T+ D D T D E
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCF-----TDHEI-- 404
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDH 476
P R S Q L+ +A +DYE A++++A D+ + AM+ I ++D ND+
Sbjct: 405 --PFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
P F QS +++PE+++ G +T + A D D+G +I Y L P + F +D +G
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLT-KVSAMDADSGPNAKINYLLGP-DAPPEFSLDCRTG 520
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+TV + LDRE + Y T+ A D G L+S+ T+ + ++D NDN+PV + YN +
Sbjct: 521 MLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFY 578
Query: 594 VQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
V E D +NS + ++L + +F++D TG++R DRE
Sbjct: 579 VPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREK- 635
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDP 709
+ V D G + VTI V D+NDN P+F + SY + +P
Sbjct: 636 ----QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSG 736
G +V V A D D T N + +S+ G
Sbjct: 692 GTVVFQVIAVDND-TGMNAEVRYSIVG 717
Score = 153 bits (386), Expect = 1e-36
Identities = 211/850 (24%), Positives = 355/850 (41%), Gaps = 133/850 (15%)
Query: 296 VIRVNGSLDREQL---LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPE 352
+ +DRE+L + DE +V I E + + + D+ND+ P
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVA-----ILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 353 FYNCSLPACTFT---PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG 409
F PA PE + +N ++ P DPD G NG L
Sbjct: 139 F-----PATVINISIPENSAIN-----SKYTLP---------AAVDPDVGINGVQNYELI 179
Query: 410 GPDAEAFSVSP-ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVT 467
F + E G Q++V+ +D E + ++V D Q S A++
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKE--LDREEKDTYVMKVKVEDGGFPQRSSTAILQ 236
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYS---LLPGN 524
+ + D ND+ P F ++ +++PE++ G+ VT +HATD D G +I +S L+
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQ-LHATDADIGENAKIHFSFSNLVSNI 295
Query: 525 GADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP 584
LF ++ +G +T++ E LDRE + L + A+DGG + + + +++ D+NDN P
Sbjct: 296 ARRLFHLNATTGLITIK--EPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 585 VVSGSY-------------NIFVQEEEGNVSVTIQAHDNDEPGT--NNSRLLFNLLPGPY 629
+ Y NI + + ++VT + D++ T + + F L P +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRP-VF 412
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIN 689
S+ F LL LD E+ + +L +D G+P L + I V+D N
Sbjct: 413 SNQF-------LLETAAYLDYESTK-----EYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNLPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
DN P+F QS ++ E + PG+ + V A DAD + N +I++ L F +
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINYLLGPDAPPEFSL---- 515
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
G L + LD E + + T+ A++ + V V V++ D NDN P
Sbjct: 516 ---DCRTGMLTVVK--KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF 570
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
+ V EN +HG V ++ +D D + L +IL F++
Sbjct: 571 -THNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTL-SILDENDD----------FTI 618
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ V I + + D E + T V+A D G + S++ + I + DVNDN P F
Sbjct: 619 DSQTGV-IRPNISFDREKQESYTFYVKA----EDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 929 L--PENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGV 986
+ P N ++ ++ P V V A D+D+G N + +SI+ G T + +
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-------GGNT---RDL 723
Query: 987 FSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLG--PFLEATTTLNLFT-- 1042
F+I D G+I + D T G ++V V+A D LG L + +NLF
Sbjct: 724 FAI------DQETGNITLMEKCDVTDLGLHRVLVKAND---LGQPDSLFSVVIVNLFVNE 774
Query: 1043 -----------VDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA 1091
V +S + + +T +V + L A T+ +V + I +
Sbjct: 775 SVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVV 834
Query: 1092 RARPHSYLDA 1101
R R +L A
Sbjct: 835 RCRQAPHLKA 844
Score = 127 bits (320), Expect = 5e-29
Identities = 167/641 (26%), Positives = 257/641 (40%), Gaps = 83/641 (12%)
Query: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFD 290
+ D D P F + S+ E++A + AVD D GIN Y + S
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI---- 184
Query: 291 IGADGVIRVNGSLDREQLLEAD---EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
G D + G + +++ + EE V + + Q + +I + V V D N
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTN 243
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F + PE A V T HA+ D D G N S
Sbjct: 244 DNHPVFKETEIEVSI--PENAPVG-TSVTQLHAT-------------DADIGENAKIHFS 287
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVT 467
+ S R + L+ + +D E + V+A+D + AMV
Sbjct: 288 F----SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVL 342
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS-----IHATDPDTGAWGQITYSLLP 522
+++ D+ND+ P+ V V + + + I TD D G++T
Sbjct: 343 VNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-- 400
Query: 523 GNGADLFQVDPV-SGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDI 579
+ F++ PV S + LD ES Y + L A D G L+ S L I + D
Sbjct: 401 -DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE 459
Query: 580 NDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLL-----------FNLLPGP 628
NDNAPV + S+ VT+ +N+ PG +++ N L GP
Sbjct: 460 NDNAPVFTQSF------------VTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP 507
Query: 629 YSH-NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVED 687
+ FSLD TG+L + LDRE E + + T+L D G P L + V V +++ D
Sbjct: 508 DAPPEFSLDCRTGMLTVVKKLDREK-----EDKYLFTILAKDNGVPPLTSNVTVFVSIID 562
Query: 688 INDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRG 746
NDN P+F + YNF V E P VG++ D D + N+ ++ S+ ++ +
Sbjct: 563 QNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDENDDFTI--- 618
Query: 747 LVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
G +R P++S D E Q + V AE+ + V +NV DVNDN P
Sbjct: 619 -----DSQTGVIR--PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Query: 807 TLDV-ASLRGIRVAENGSQHGQVAV-VVASDVDTSAQLEIQ 845
V S + + G V V+A D DT E++
Sbjct: 672 VFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Score = 127 bits (320), Expect = 5e-29
Identities = 183/730 (25%), Positives = 306/730 (41%), Gaps = 86/730 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM-SGPNAYFFAV--TP-- 74
AP F A + ++ +PE+ + ++ A D D N Y + N + V TP
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 75 -KTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
K ++ + LD E T+ + + V D P + V V D NDN PVF+ T
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGS 190
SI E PVG+ V + A D D+G + +S ++ + + LF + A ++
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI--ARRLFHLNATTGLITIKE 313
Query: 191 LSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ--PDLDPQFVREFYSA 248
++ ++L + A D GG+ + V ++++ V+ P +D +++ +
Sbjct: 314 PLDREETPNHKLLVLASD-GGL------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 249 SV--AEDAAKGTSVLTVEAVDGDKGINDPVI----YSISYSTRPGWFDIGADGVIRVNGS 302
+V +E+ T + + D D N V + I + RP + + ++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN---QFLLETAAY 423
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LD E+ +E +++ A + Q A + I +V D ND+ P F
Sbjct: 424 LD----YESTKEYAIKLLAADAGKPPLNQSAMLFI----KVKDENDNAPVF--------- 466
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
Q T + E+ SP I + ++ + D D G N L GPDA P
Sbjct: 467 -----TQSFVTVSIPENNSPGIQLTKVSAM--DADSGPNAKINYLL-GPDA------PPE 512
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFP 481
+ +L V L D E++ ++A D+ V S V + + D ND+ P F
Sbjct: 513 FSLDCRTGMLTVVKKL-DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+ Y VPE+ V I TDPD G +T S+L N D F +D S T +R
Sbjct: 572 HNEYNFYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDEN--DDFTID--SQTGVIR 626
Query: 542 NGELLDRESQAVYYLTLQATDGGNL--SSSTTLQIHLLDINDNAPVV-----SGSYNIFV 594
DRE Q Y ++A DGG + SSS + I+++D+NDN PV + SY + +
Sbjct: 627 PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 595 -QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
G V + A DND N+ + ++++ G F++D +TG + + E
Sbjct: 687 PSTNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTRDLFAIDQETGNITLM-----EKC 739
Query: 654 DPALEGRIVLTVLVSDCGEP-VLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL 712
D G + V +D G+P L + V V + V + N + N+ T P
Sbjct: 740 DVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTE 799
Query: 713 VGVVKAWDAD 722
+ V + +D
Sbjct: 800 IADVSSPTSD 809
Score = 94.7 bits (234), Expect = 5e-19
Identities = 141/582 (24%), Positives = 239/582 (41%), Gaps = 69/582 (11%)
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTVTVRNGELLD 547
+PE+ G ++ D + P+ + + L+ G L +++ +G + G +D
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFT-TGARID 92
Query: 548 RES--------QAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-NIFVQEEE 598
RE + +Y A + ++ + DINDNAP+ + NI + E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 599 G-NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD----PDTGLLRNLGPLDREAI 653
N T+ A + + G N + + L+ + F LD P+ + L + ++ +
Sbjct: 153 AINSKYTLPAAVDPDVGINGVQN-YELIKS--QNIFGLDVIETPEGDKMPQL--IVQKEL 207
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVL 712
D + V+ V V D G P + + ++V D NDN P+F ++ ++ E P G
Sbjct: 208 DREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTS 267
Query: 713 VGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQP 772
V + A DAD E N +I FS S +N I + G + + LD E P
Sbjct: 268 VTQLHATDADIGE-NAKIHFSFSNLVSN---IARRLFHLNATTGLITIKEP--LDREETP 321
Query: 773 VFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG-----IRVAENGSQHGQ 827
L V A + +V VNV DVNDN P++D+ + + ++EN + +
Sbjct: 322 NHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 828 VAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEAC 887
+A++ +D D + + + V +N + + +DYE+
Sbjct: 380 IALITVTDKDADHNGRVTCFTD---------HEIPFRLRPVFSN-QFLLETAAYLDYEST 429
Query: 888 DLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNRE 947
+ + LA D G + + L I ++D NDNAP F T V IPE P +
Sbjct: 430 KEYAIKL----LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT-VSIPENNSPGIQ 484
Query: 948 VASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTS 1007
+ V A D DSG N I + + G P + FS+ D G + V
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---------GPDAPPE--FSL------DCRTGMLTVVKK 527
Query: 1008 LDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRS 1049
LD + Y T+ A+D P L + T+ + +DQ+ S
Sbjct: 528 LDREKEDKYLFTILAKDNGV--PPLTSNVTVFVSIIDQNDNS 567
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 172 bits (437), Expect = 1e-42
Identities = 187/687 (27%), Positives = 298/687 (43%), Gaps = 74/687 (10%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F + KL + + + ++V +++ I ++ ++ED NDNAP+F T
Sbjct: 85 FTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVI 144
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----LANG-- 183
+ SI E + S AVD D+G G+ Y + K S+++F + G
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-------SQNIFGLDVIETPEGDK 197
Query: 184 --SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF 241
+++ L K Y +++K D GG + T L +SV D D P F
Sbjct: 198 MPQLIVQKELDREEKDT-YVMKVKVED-GGFPQRSST------AILQVSVTDTNDNHPVF 249
Query: 242 VREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS----ISYSTRPGWFDIGADGVI 297
S+ E+A GTSV + A D D G N + +S +S R + G+I
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
+ LDRE+ +L V A++ G V V V DVND +
Sbjct: 310 TIKEPLDREE----TPNHKLLVLASD------GGLMPARAMVLVNVTDVND--------N 351
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+P+ VN T + E+ I +T+ D D T D E
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCF-----TDHEI-- 404
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDH 476
P R S Q L+ +A +DYE A++++A D+ + AM+ I ++D ND+
Sbjct: 405 --PFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
P F QS +++PE+++ G +T + A D D+G +I Y L P + F +D +G
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLT-KVSAMDADSGPNAKINYLLGP-DAPPEFSLDCRTG 520
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+TV + LDRE + Y T+ A D G L+S+ T+ + ++D NDN+PV + YN +
Sbjct: 521 MLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFY 578
Query: 594 VQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
V E D +NS + ++L + +F++D TG++R DRE
Sbjct: 579 VPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREK- 635
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDP 709
+ V D G + VTI V D+NDN P+F + SY + +P
Sbjct: 636 ----QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSG 736
G +V V A D D T N + +S+ G
Sbjct: 692 GTVVFQVIAVDND-TGMNAEVRYSIVG 717
Score = 153 bits (386), Expect = 1e-36
Identities = 211/850 (24%), Positives = 355/850 (41%), Gaps = 133/850 (15%)
Query: 296 VIRVNGSLDREQL---LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPE 352
+ +DRE+L + DE +V I E + + + D+ND+ P
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVA-----ILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 353 FYNCSLPACTFT---PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG 409
F PA PE + +N ++ P DPD G NG L
Sbjct: 139 F-----PATVINISIPENSAIN-----SKYTLP---------AAVDPDVGINGVQNYELI 179
Query: 410 GPDAEAFSVSP-ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVT 467
F + E G Q++V+ +D E + ++V D Q S A++
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKE--LDREEKDTYVMKVKVEDGGFPQRSSTAILQ 236
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYS---LLPGN 524
+ + D ND+ P F ++ +++PE++ G+ VT +HATD D G +I +S L+
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQ-LHATDADIGENAKIHFSFSNLVSNI 295
Query: 525 GADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP 584
LF ++ +G +T++ E LDRE + L + A+DGG + + + +++ D+NDN P
Sbjct: 296 ARRLFHLNATTGLITIK--EPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 585 VVSGSY-------------NIFVQEEEGNVSVTIQAHDNDEPGT--NNSRLLFNLLPGPY 629
+ Y NI + + ++VT + D++ T + + F L P +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRP-VF 412
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIN 689
S+ F LL LD E+ + +L +D G+P L + I V+D N
Sbjct: 413 SNQF-------LLETAAYLDYESTK-----EYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNLPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
DN P+F QS ++ E + PG+ + V A DAD + N +I++ L F +
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINYLLGPDAPPEFSL---- 515
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
G L + LD E + + T+ A++ + V V V++ D NDN P
Sbjct: 516 ---DCRTGMLTVVK--KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF 570
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
+ V EN +HG V ++ +D D + L +IL F++
Sbjct: 571 -THNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTL-SILDENDD----------FTI 618
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ V I + + D E + T V+A D G + S++ + I + DVNDN P F
Sbjct: 619 DSQTGV-IRPNISFDREKQESYTFYVKA----EDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 929 L--PENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGV 986
+ P N ++ ++ P V V A D+D+G N + +SI+ G T + +
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-------GGNT---RDL 723
Query: 987 FSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLG--PFLEATTTLNLFT-- 1042
F+I D G+I + D T G ++V V+A D LG L + +NLF
Sbjct: 724 FAI------DQETGNITLMEKCDVTDLGLHRVLVKAND---LGQPDSLFSVVIVNLFVNE 774
Query: 1043 -----------VDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA 1091
V +S + + +T +V + L A T+ +V + I +
Sbjct: 775 SVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVV 834
Query: 1092 RARPHSYLDA 1101
R R +L A
Sbjct: 835 RCRQAPHLKA 844
Score = 127 bits (320), Expect = 5e-29
Identities = 167/641 (26%), Positives = 257/641 (40%), Gaps = 83/641 (12%)
Query: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFD 290
+ D D P F + S+ E++A + AVD D GIN Y + S
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI---- 184
Query: 291 IGADGVIRVNGSLDREQLLEAD---EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
G D + G + +++ + EE V + + Q + +I + V V D N
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTN 243
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F + PE A V T HA+ D D G N S
Sbjct: 244 DNHPVFKETEIEVSI--PENAPVG-TSVTQLHAT-------------DADIGENAKIHFS 287
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVT 467
+ S R + L+ + +D E + V+A+D + AMV
Sbjct: 288 F----SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVL 342
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS-----IHATDPDTGAWGQITYSLLP 522
+++ D+ND+ P+ V V + + + I TD D G++T
Sbjct: 343 VNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-- 400
Query: 523 GNGADLFQVDPV-SGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDI 579
+ F++ PV S + LD ES Y + L A D G L+ S L I + D
Sbjct: 401 -DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE 459
Query: 580 NDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLL-----------FNLLPGP 628
NDNAPV + S+ VT+ +N+ PG +++ N L GP
Sbjct: 460 NDNAPVFTQSF------------VTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP 507
Query: 629 YSH-NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVED 687
+ FSLD TG+L + LDRE E + + T+L D G P L + V V +++ D
Sbjct: 508 DAPPEFSLDCRTGMLTVVKKLDREK-----EDKYLFTILAKDNGVPPLTSNVTVFVSIID 562
Query: 688 INDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRG 746
NDN P+F + YNF V E P VG++ D D + N+ ++ S+ ++ +
Sbjct: 563 QNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDENDDFTI--- 618
Query: 747 LVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
G +R P++S D E Q + V AE+ + V +NV DVNDN P
Sbjct: 619 -----DSQTGVIR--PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Query: 807 TLDV-ASLRGIRVAENGSQHGQVAV-VVASDVDTSAQLEIQ 845
V S + + G V V+A D DT E++
Sbjct: 672 VFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Score = 127 bits (320), Expect = 5e-29
Identities = 183/730 (25%), Positives = 306/730 (41%), Gaps = 86/730 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM-SGPNAYFFAV--TP-- 74
AP F A + ++ +PE+ + ++ A D D N Y + N + V TP
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 75 -KTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
K ++ + LD E T+ + + V D P + V V D NDN PVF+ T
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGS 190
SI E PVG+ V + A D D+G + +S ++ + + LF + A ++
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI--ARRLFHLNATTGLITIKE 313
Query: 191 LSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ--PDLDPQFVREFYSA 248
++ ++L + A D GG+ + V ++++ V+ P +D +++ +
Sbjct: 314 PLDREETPNHKLLVLASD-GGL------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 249 SV--AEDAAKGTSVLTVEAVDGDKGINDPVI----YSISYSTRPGWFDIGADGVIRVNGS 302
+V +E+ T + + D D N V + I + RP + + ++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN---QFLLETAAY 423
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LD E+ +E +++ A + Q A + I +V D ND+ P F
Sbjct: 424 LD----YESTKEYAIKLLAADAGKPPLNQSAMLFI----KVKDENDNAPVF--------- 466
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
Q T + E+ SP I + ++ + D D G N L GPDA P
Sbjct: 467 -----TQSFVTVSIPENNSPGIQLTKVSAM--DADSGPNAKINYLL-GPDA------PPE 512
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFP 481
+ +L V L D E++ ++A D+ V S V + + D ND+ P F
Sbjct: 513 FSLDCRTGMLTVVKKL-DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+ Y VPE+ V I TDPD G +T S+L N D F +D S T +R
Sbjct: 572 HNEYNFYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDEN--DDFTID--SQTGVIR 626
Query: 542 NGELLDRESQAVYYLTLQATDGGNL--SSSTTLQIHLLDINDNAPVV-----SGSYNIFV 594
DRE Q Y ++A DGG + SSS + I+++D+NDN PV + SY + +
Sbjct: 627 PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 595 -QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
G V + A DND N+ + ++++ G F++D +TG + + E
Sbjct: 687 PSTNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTRDLFAIDQETGNITLM-----EKC 739
Query: 654 DPALEGRIVLTVLVSDCGEP-VLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL 712
D G + V +D G+P L + V V + V + N + N+ T P
Sbjct: 740 DVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTE 799
Query: 713 VGVVKAWDAD 722
+ V + +D
Sbjct: 800 IADVSSPTSD 809
Score = 94.7 bits (234), Expect = 5e-19
Identities = 141/582 (24%), Positives = 239/582 (41%), Gaps = 69/582 (11%)
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTVTVRNGELLD 547
+PE+ G ++ D + P+ + + L+ G L +++ +G + G +D
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFT-TGARID 92
Query: 548 RES--------QAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-NIFVQEEE 598
RE + +Y A + ++ + DINDNAP+ + NI + E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 599 G-NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD----PDTGLLRNLGPLDREAI 653
N T+ A + + G N + + L+ + F LD P+ + L + ++ +
Sbjct: 153 AINSKYTLPAAVDPDVGINGVQN-YELIKS--QNIFGLDVIETPEGDKMPQL--IVQKEL 207
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVL 712
D + V+ V V D G P + + ++V D NDN P+F ++ ++ E P G
Sbjct: 208 DREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTS 267
Query: 713 VGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQP 772
V + A DAD E N +I FS S +N I + G + + LD E P
Sbjct: 268 VTQLHATDADIGE-NAKIHFSFSNLVSN---IARRLFHLNATTGLITIKEP--LDREETP 321
Query: 773 VFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG-----IRVAENGSQHGQ 827
L V A + +V VNV DVNDN P++D+ + + ++EN + +
Sbjct: 322 NHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 828 VAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEAC 887
+A++ +D D + + + V +N + + +DYE+
Sbjct: 380 IALITVTDKDADHNGRVTCFTD---------HEIPFRLRPVFSN-QFLLETAAYLDYEST 429
Query: 888 DLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNRE 947
+ + LA D G + + L I ++D NDNAP F T V IPE P +
Sbjct: 430 KEYAIKL----LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT-VSIPENNSPGIQ 484
Query: 948 VASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTS 1007
+ V A D DSG N I + + G P + FS+ D G + V
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---------GPDAPPE--FSL------DCRTGMLTVVKK 527
Query: 1008 LDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRS 1049
LD + Y T+ A+D P L + T+ + +DQ+ S
Sbjct: 528 LDREKEDKYLFTILAKDNGV--PPLTSNVTVFVSIIDQNDNS 567
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 172 bits (437), Expect = 1e-42
Identities = 187/687 (27%), Positives = 298/687 (43%), Gaps = 74/687 (10%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F + KL + + + ++V +++ I ++ ++ED NDNAP+F T
Sbjct: 85 FTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVI 144
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----LANG-- 183
+ SI E + S AVD D+G G+ Y + K S+++F + G
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-------SQNIFGLDVIETPEGDK 197
Query: 184 --SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF 241
+++ L K Y +++K D GG + T L +SV D D P F
Sbjct: 198 MPQLIVQKELDREEKDT-YVMKVKVED-GGFPQRSST------AILQVSVTDTNDNHPVF 249
Query: 242 VREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS----ISYSTRPGWFDIGADGVI 297
S+ E+A GTSV + A D D G N + +S +S R + G+I
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
+ LDRE+ +L V A++ G V V V DVND +
Sbjct: 310 TIKEPLDREE----TPNHKLLVLASD------GGLMPARAMVLVNVTDVND--------N 351
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+P+ VN T + E+ I +T+ D D T D E
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCF-----TDHEI-- 404
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDH 476
P R S Q L+ +A +DYE A++++A D+ + AM+ I ++D ND+
Sbjct: 405 --PFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
P F QS +++PE+++ G +T + A D D+G +I Y L P + F +D +G
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLT-KVSAMDADSGPNAKINYLLGP-DAPPEFSLDCRTG 520
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+TV + LDRE + Y T+ A D G L+S+ T+ + ++D NDN+PV + YN +
Sbjct: 521 MLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFY 578
Query: 594 VQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
V E D +NS + ++L + +F++D TG++R DRE
Sbjct: 579 VPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREK- 635
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDP 709
+ V D G + VTI V D+NDN P+F + SY + +P
Sbjct: 636 ----QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSG 736
G +V V A D D T N + +S+ G
Sbjct: 692 GTVVFQVIAVDND-TGMNAEVRYSIVG 717
Score = 153 bits (386), Expect = 1e-36
Identities = 211/850 (24%), Positives = 355/850 (41%), Gaps = 133/850 (15%)
Query: 296 VIRVNGSLDREQL---LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPE 352
+ +DRE+L + DE +V I E + + + D+ND+ P
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVA-----ILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 353 FYNCSLPACTFT---PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG 409
F PA PE + +N ++ P DPD G NG L
Sbjct: 139 F-----PATVINISIPENSAIN-----SKYTLP---------AAVDPDVGINGVQNYELI 179
Query: 410 GPDAEAFSVSP-ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVT 467
F + E G Q++V+ +D E + ++V D Q S A++
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKE--LDREEKDTYVMKVKVEDGGFPQRSSTAILQ 236
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYS---LLPGN 524
+ + D ND+ P F ++ +++PE++ G+ VT +HATD D G +I +S L+
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQ-LHATDADIGENAKIHFSFSNLVSNI 295
Query: 525 GADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP 584
LF ++ +G +T++ E LDRE + L + A+DGG + + + +++ D+NDN P
Sbjct: 296 ARRLFHLNATTGLITIK--EPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 585 VVSGSY-------------NIFVQEEEGNVSVTIQAHDNDEPGT--NNSRLLFNLLPGPY 629
+ Y NI + + ++VT + D++ T + + F L P +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRP-VF 412
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIN 689
S+ F LL LD E+ + +L +D G+P L + I V+D N
Sbjct: 413 SNQF-------LLETAAYLDYESTK-----EYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNLPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
DN P+F QS ++ E + PG+ + V A DAD + N +I++ L F +
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINYLLGPDAPPEFSL---- 515
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
G L + LD E + + T+ A++ + V V V++ D NDN P
Sbjct: 516 ---DCRTGMLTVVK--KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF 570
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
+ V EN +HG V ++ +D D + L +IL F++
Sbjct: 571 -THNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTL-SILDENDD----------FTI 618
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ V I + + D E + T V+A D G + S++ + I + DVNDN P F
Sbjct: 619 DSQTGV-IRPNISFDREKQESYTFYVKA----EDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 929 L--PENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGV 986
+ P N ++ ++ P V V A D+D+G N + +SI+ G T + +
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-------GGNT---RDL 723
Query: 987 FSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLG--PFLEATTTLNLFT-- 1042
F+I D G+I + D T G ++V V+A D LG L + +NLF
Sbjct: 724 FAI------DQETGNITLMEKCDVTDLGLHRVLVKAND---LGQPDSLFSVVIVNLFVNE 774
Query: 1043 -----------VDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA 1091
V +S + + +T +V + L A T+ +V + I +
Sbjct: 775 SVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVV 834
Query: 1092 RARPHSYLDA 1101
R R +L A
Sbjct: 835 RCRQAPHLKA 844
Score = 127 bits (320), Expect = 5e-29
Identities = 167/641 (26%), Positives = 257/641 (40%), Gaps = 83/641 (12%)
Query: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFD 290
+ D D P F + S+ E++A + AVD D GIN Y + S
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI---- 184
Query: 291 IGADGVIRVNGSLDREQLLEAD---EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
G D + G + +++ + EE V + + Q + +I + V V D N
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTN 243
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F + PE A V T HA+ D D G N S
Sbjct: 244 DNHPVFKETEIEVSI--PENAPVG-TSVTQLHAT-------------DADIGENAKIHFS 287
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVT 467
+ S R + L+ + +D E + V+A+D + AMV
Sbjct: 288 F----SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVL 342
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS-----IHATDPDTGAWGQITYSLLP 522
+++ D+ND+ P+ V V + + + I TD D G++T
Sbjct: 343 VNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-- 400
Query: 523 GNGADLFQVDPV-SGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDI 579
+ F++ PV S + LD ES Y + L A D G L+ S L I + D
Sbjct: 401 -DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE 459
Query: 580 NDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLL-----------FNLLPGP 628
NDNAPV + S+ VT+ +N+ PG +++ N L GP
Sbjct: 460 NDNAPVFTQSF------------VTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP 507
Query: 629 YSH-NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVED 687
+ FSLD TG+L + LDRE E + + T+L D G P L + V V +++ D
Sbjct: 508 DAPPEFSLDCRTGMLTVVKKLDREK-----EDKYLFTILAKDNGVPPLTSNVTVFVSIID 562
Query: 688 INDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRG 746
NDN P+F + YNF V E P VG++ D D + N+ ++ S+ ++ +
Sbjct: 563 QNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDENDDFTI--- 618
Query: 747 LVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
G +R P++S D E Q + V AE+ + V +NV DVNDN P
Sbjct: 619 -----DSQTGVIR--PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Query: 807 TLDV-ASLRGIRVAENGSQHGQVAV-VVASDVDTSAQLEIQ 845
V S + + G V V+A D DT E++
Sbjct: 672 VFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Score = 127 bits (320), Expect = 5e-29
Identities = 183/730 (25%), Positives = 306/730 (41%), Gaps = 86/730 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM-SGPNAYFFAV--TP-- 74
AP F A + ++ +PE+ + ++ A D D N Y + N + V TP
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 75 -KTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
K ++ + LD E T+ + + V D P + V V D NDN PVF+ T
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGS 190
SI E PVG+ V + A D D+G + +S ++ + + LF + A ++
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI--ARRLFHLNATTGLITIKE 313
Query: 191 LSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ--PDLDPQFVREFYSA 248
++ ++L + A D GG+ + V ++++ V+ P +D +++ +
Sbjct: 314 PLDREETPNHKLLVLASD-GGL------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 249 SV--AEDAAKGTSVLTVEAVDGDKGINDPVI----YSISYSTRPGWFDIGADGVIRVNGS 302
+V +E+ T + + D D N V + I + RP + + ++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN---QFLLETAAY 423
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LD E+ +E +++ A + Q A + I +V D ND+ P F
Sbjct: 424 LD----YESTKEYAIKLLAADAGKPPLNQSAMLFI----KVKDENDNAPVF--------- 466
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
Q T + E+ SP I + ++ + D D G N L GPDA P
Sbjct: 467 -----TQSFVTVSIPENNSPGIQLTKVSAM--DADSGPNAKINYLL-GPDA------PPE 512
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFP 481
+ +L V L D E++ ++A D+ V S V + + D ND+ P F
Sbjct: 513 FSLDCRTGMLTVVKKL-DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+ Y VPE+ V I TDPD G +T S+L N D F +D S T +R
Sbjct: 572 HNEYNFYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDEN--DDFTID--SQTGVIR 626
Query: 542 NGELLDRESQAVYYLTLQATDGGNL--SSSTTLQIHLLDINDNAPVV-----SGSYNIFV 594
DRE Q Y ++A DGG + SSS + I+++D+NDN PV + SY + +
Sbjct: 627 PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 595 -QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
G V + A DND N+ + ++++ G F++D +TG + + E
Sbjct: 687 PSTNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTRDLFAIDQETGNITLM-----EKC 739
Query: 654 DPALEGRIVLTVLVSDCGEP-VLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL 712
D G + V +D G+P L + V V + V + N + N+ T P
Sbjct: 740 DVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTE 799
Query: 713 VGVVKAWDAD 722
+ V + +D
Sbjct: 800 IADVSSPTSD 809
Score = 94.7 bits (234), Expect = 5e-19
Identities = 141/582 (24%), Positives = 239/582 (41%), Gaps = 69/582 (11%)
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTVTVRNGELLD 547
+PE+ G ++ D + P+ + + L+ G L +++ +G + G +D
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFT-TGARID 92
Query: 548 RES--------QAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-NIFVQEEE 598
RE + +Y A + ++ + DINDNAP+ + NI + E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 599 G-NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD----PDTGLLRNLGPLDREAI 653
N T+ A + + G N + + L+ + F LD P+ + L + ++ +
Sbjct: 153 AINSKYTLPAAVDPDVGINGVQN-YELIKS--QNIFGLDVIETPEGDKMPQL--IVQKEL 207
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVL 712
D + V+ V V D G P + + ++V D NDN P+F ++ ++ E P G
Sbjct: 208 DREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTS 267
Query: 713 VGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQP 772
V + A DAD E N +I FS S +N I + G + + LD E P
Sbjct: 268 VTQLHATDADIGE-NAKIHFSFSNLVSN---IARRLFHLNATTGLITIKEP--LDREETP 321
Query: 773 VFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG-----IRVAENGSQHGQ 827
L V A + +V VNV DVNDN P++D+ + + ++EN + +
Sbjct: 322 NHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 828 VAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEAC 887
+A++ +D D + + + V +N + + +DYE+
Sbjct: 380 IALITVTDKDADHNGRVTCFTD---------HEIPFRLRPVFSN-QFLLETAAYLDYEST 429
Query: 888 DLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNRE 947
+ + LA D G + + L I ++D NDNAP F T V IPE P +
Sbjct: 430 KEYAIKL----LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT-VSIPENNSPGIQ 484
Query: 948 VASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTS 1007
+ V A D DSG N I + + G P + FS+ D G + V
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---------GPDAPPE--FSL------DCRTGMLTVVKK 527
Query: 1008 LDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRS 1049
LD + Y T+ A+D P L + T+ + +DQ+ S
Sbjct: 528 LDREKEDKYLFTILAKDNGV--PPLTSNVTVFVSIIDQNDNS 567
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 172 bits (437), Expect = 1e-42
Identities = 187/687 (27%), Positives = 298/687 (43%), Gaps = 74/687 (10%)
Query: 70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129
F + KL + + + ++V +++ I ++ ++ED NDNAP+F T
Sbjct: 85 FTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVI 144
Query: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----LANG-- 183
+ SI E + S AVD D+G G+ Y + K S+++F + G
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-------SQNIFGLDVIETPEGDK 197
Query: 184 --SIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQF 241
+++ L K Y +++K D GG + T L +SV D D P F
Sbjct: 198 MPQLIVQKELDREEKDT-YVMKVKVED-GGFPQRSST------AILQVSVTDTNDNHPVF 249
Query: 242 VREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS----ISYSTRPGWFDIGADGVI 297
S+ E+A GTSV + A D D G N + +S +S R + G+I
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 298 RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCS 357
+ LDRE+ +L V A++ G V V V DVND +
Sbjct: 310 TIKEPLDREE----TPNHKLLVLASD------GGLMPARAMVLVNVTDVND--------N 351
Query: 358 LPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFS 417
+P+ VN T + E+ I +T+ D D T D E
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCF-----TDHEI-- 404
Query: 418 VSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS-VAMVTIHLRDINDH 476
P R S Q L+ +A +DYE A++++A D+ + AM+ I ++D ND+
Sbjct: 405 --PFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
P F QS +++PE+++ G +T + A D D+G +I Y L P + F +D +G
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLT-KVSAMDADSGPNAKINYLLGP-DAPPEFSLDCRTG 520
Query: 537 TVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
+TV + LDRE + Y T+ A D G L+S+ T+ + ++D NDN+PV + YN +
Sbjct: 521 MLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFY 578
Query: 594 VQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
V E D +NS + ++L + +F++D TG++R DRE
Sbjct: 579 VPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREK- 635
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIF----NQSSYNFTVKEEDP 709
+ V D G + VTI V D+NDN P+F + SY + +P
Sbjct: 636 ----QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 710 GVLVGVVKAWDADQTEANNRISFSLSG 736
G +V V A D D T N + +S+ G
Sbjct: 692 GTVVFQVIAVDND-TGMNAEVRYSIVG 717
Score = 153 bits (386), Expect = 1e-36
Identities = 211/850 (24%), Positives = 355/850 (41%), Gaps = 133/850 (15%)
Query: 296 VIRVNGSLDREQL---LEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPE 352
+ +DRE+L + DE +V I E + + + D+ND+ P
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVA-----ILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 353 FYNCSLPACTFT---PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLG 409
F PA PE + +N ++ P DPD G NG L
Sbjct: 139 F-----PATVINISIPENSAIN-----SKYTLP---------AAVDPDVGINGVQNYELI 179
Query: 410 GPDAEAFSVSP-ERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVT 467
F + E G Q++V+ +D E + ++V D Q S A++
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKE--LDREEKDTYVMKVKVEDGGFPQRSSTAILQ 236
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYS---LLPGN 524
+ + D ND+ P F ++ +++PE++ G+ VT +HATD D G +I +S L+
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQ-LHATDADIGENAKIHFSFSNLVSNI 295
Query: 525 GADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP 584
LF ++ +G +T++ E LDRE + L + A+DGG + + + +++ D+NDN P
Sbjct: 296 ARRLFHLNATTGLITIK--EPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 585 VVSGSY-------------NIFVQEEEGNVSVTIQAHDNDEPGT--NNSRLLFNLLPGPY 629
+ Y NI + + ++VT + D++ T + + F L P +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRP-VF 412
Query: 630 SHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDIN 689
S+ F LL LD E+ + +L +D G+P L + I V+D N
Sbjct: 413 SNQF-------LLETAAYLDYESTK-----EYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNLPIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLV 748
DN P+F QS ++ E + PG+ + V A DAD + N +I++ L F +
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINYLLGPDAPPEFSL---- 515
Query: 749 LGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808
G L + LD E + + T+ A++ + V V V++ D NDN P
Sbjct: 516 ---DCRTGMLTVVK--KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF 570
Query: 809 DVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSV 868
+ V EN +HG V ++ +D D + L +IL F++
Sbjct: 571 -THNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTL-SILDENDD----------FTI 618
Query: 869 AANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYF 928
+ V I + + D E + T V+A D G + S++ + I + DVNDN P F
Sbjct: 619 DSQTGV-IRPNISFDREKQESYTFYVKA----EDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 929 L--PENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGV 986
+ P N ++ ++ P V V A D+D+G N + +SI+ G T + +
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-------GGNT---RDL 723
Query: 987 FSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLG--PFLEATTTLNLFT-- 1042
F+I D G+I + D T G ++V V+A D LG L + +NLF
Sbjct: 724 FAI------DQETGNITLMEKCDVTDLGLHRVLVKAND---LGQPDSLFSVVIVNLFVNE 774
Query: 1043 -----------VDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA 1091
V +S + + +T +V + L A T+ +V + I +
Sbjct: 775 SVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVV 834
Query: 1092 RARPHSYLDA 1101
R R +L A
Sbjct: 835 RCRQAPHLKA 844
Score = 127 bits (320), Expect = 5e-29
Identities = 167/641 (26%), Positives = 257/641 (40%), Gaps = 83/641 (12%)
Query: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFD 290
+ D D P F + S+ E++A + AVD D GIN Y + S
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI---- 184
Query: 291 IGADGVIRVNGSLDREQLLEAD---EEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVN 347
G D + G + +++ + EE V + + Q + +I + V V D N
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTN 243
Query: 348 DHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLS 407
D+ P F + PE A V T HA+ D D G N S
Sbjct: 244 DNHPVFKETEIEVSI--PENAPVG-TSVTQLHAT-------------DADIGENAKIHFS 287
Query: 408 LGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVT 467
+ S R + L+ + +D E + V+A+D + AMV
Sbjct: 288 F----SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVL 342
Query: 468 IHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS-----IHATDPDTGAWGQITYSLLP 522
+++ D+ND+ P+ V V + + + I TD D G++T
Sbjct: 343 VNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-- 400
Query: 523 GNGADLFQVDPV-SGTVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDI 579
+ F++ PV S + LD ES Y + L A D G L+ S L I + D
Sbjct: 401 -DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE 459
Query: 580 NDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLL-----------FNLLPGP 628
NDNAPV + S+ VT+ +N+ PG +++ N L GP
Sbjct: 460 NDNAPVFTQSF------------VTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP 507
Query: 629 YSH-NFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVED 687
+ FSLD TG+L + LDRE E + + T+L D G P L + V V +++ D
Sbjct: 508 DAPPEFSLDCRTGMLTVVKKLDREK-----EDKYLFTILAKDNGVPPLTSNVTVFVSIID 562
Query: 688 INDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRG 746
NDN P+F + YNF V E P VG++ D D + N+ ++ S+ ++ +
Sbjct: 563 QNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDENDDFTI--- 618
Query: 747 LVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806
G +R P++S D E Q + V AE+ + V +NV DVNDN P
Sbjct: 619 -----DSQTGVIR--PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Query: 807 TLDV-ASLRGIRVAENGSQHGQVAV-VVASDVDTSAQLEIQ 845
V S + + G V V+A D DT E++
Sbjct: 672 VFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Score = 127 bits (320), Expect = 5e-29
Identities = 183/730 (25%), Positives = 306/730 (41%), Gaps = 86/730 (11%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGM-SGPNAYFFAV--TP-- 74
AP F A + ++ +PE+ + ++ A D D N Y + N + V TP
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 75 -KTGEVKLASALDYETLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFS 130
K ++ + LD E T+ + + V D P + V V D NDN PVF+ T
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 131 TSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGS 190
SI E PVG+ V + A D D+G + +S ++ + + LF + A ++
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI--ARRLFHLNATTGLITIKE 313
Query: 191 LSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ--PDLDPQFVREFYSA 248
++ ++L + A D GG+ + V ++++ V+ P +D +++ +
Sbjct: 314 PLDREETPNHKLLVLASD-GGL------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 249 SV--AEDAAKGTSVLTVEAVDGDKGINDPVI----YSISYSTRPGWFDIGADGVIRVNGS 302
+V +E+ T + + D D N V + I + RP + + ++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN---QFLLETAAY 423
Query: 303 LDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACT 362
LD E+ +E +++ A + Q A + I +V D ND+ P F
Sbjct: 424 LD----YESTKEYAIKLLAADAGKPPLNQSAMLFI----KVKDENDNAPVF--------- 466
Query: 363 FTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPER 422
Q T + E+ SP I + ++ + D D G N L GPDA P
Sbjct: 467 -----TQSFVTVSIPENNSPGIQLTKVSAM--DADSGPNAKINYLL-GPDA------PPE 512
Query: 423 AAGSASVQVLVRVSALVDYERQTAMAVQVVATDS-VSQNFSVAMVTIHLRDINDHRPTFP 481
+ +L V L D E++ ++A D+ V S V + + D ND+ P F
Sbjct: 513 FSLDCRTGMLTVVKKL-DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+ Y VPE+ V I TDPD G +T S+L N D F +D S T +R
Sbjct: 572 HNEYNFYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDEN--DDFTID--SQTGVIR 626
Query: 542 NGELLDRESQAVYYLTLQATDGGNL--SSSTTLQIHLLDINDNAPVV-----SGSYNIFV 594
DRE Q Y ++A DGG + SSS + I+++D+NDN PV + SY + +
Sbjct: 627 PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 595 -QEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
G V + A DND N+ + ++++ G F++D +TG + + E
Sbjct: 687 PSTNPGTVVFQVIAVDNDT--GMNAEVRYSIVGGNTRDLFAIDQETGNITLM-----EKC 739
Query: 654 DPALEGRIVLTVLVSDCGEP-VLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL 712
D G + V +D G+P L + V V + V + N + N+ T P
Sbjct: 740 DVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTE 799
Query: 713 VGVVKAWDAD 722
+ V + +D
Sbjct: 800 IADVSSPTSD 809
Score = 94.7 bits (234), Expect = 5e-19
Identities = 141/582 (24%), Positives = 239/582 (41%), Gaps = 69/582 (11%)
Query: 489 VPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTVTVRNGELLD 547
+PE+ G ++ D + P+ + + L+ G L +++ +G + G +D
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFT-TGARID 92
Query: 548 RES--------QAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSY-NIFVQEEE 598
RE + +Y A + ++ + DINDNAP+ + NI + E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 599 G-NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLD----PDTGLLRNLGPLDREAI 653
N T+ A + + G N + + L+ + F LD P+ + L + ++ +
Sbjct: 153 AINSKYTLPAAVDPDVGINGVQN-YELIKS--QNIFGLDVIETPEGDKMPQL--IVQKEL 207
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVL 712
D + V+ V V D G P + + ++V D NDN P+F ++ ++ E P G
Sbjct: 208 DREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTS 267
Query: 713 VGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQP 772
V + A DAD E N +I FS S +N I + G + + LD E P
Sbjct: 268 VTQLHATDADIGE-NAKIHFSFSNLVSN---IARRLFHLNATTGLITIKEP--LDREETP 321
Query: 773 VFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG-----IRVAENGSQHGQ 827
L V A + +V VNV DVNDN P++D+ + + ++EN + +
Sbjct: 322 NHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 828 VAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEAC 887
+A++ +D D + + + V +N + + +DYE+
Sbjct: 380 IALITVTDKDADHNGRVTCFTD---------HEIPFRLRPVFSN-QFLLETAAYLDYEST 429
Query: 888 DLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNRE 947
+ + LA D G + + L I ++D NDNAP F T V IPE P +
Sbjct: 430 KEYAIKL----LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT-VSIPENNSPGIQ 484
Query: 948 VASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTS 1007
+ V A D DSG N I + + G P + FS+ D G + V
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---------GPDAPPE--FSL------DCRTGMLTVVKK 527
Query: 1008 LDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRS 1049
LD + Y T+ A+D P L + T+ + +DQ+ S
Sbjct: 528 LDREKEDKYLFTILAKDNGV--PPLTSNVTVFVSIIDQNDNS 567
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo
sapiens]
Length = 1790
Score = 172 bits (435), Expect = 2e-42
Identities = 229/913 (25%), Positives = 377/913 (41%), Gaps = 141/913 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 134 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 193
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 194 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 253 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 304
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 305 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 364
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 365 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 406
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPDAEAF-----SVSPE 421
GY+ E A I D L +V D D + P+ F SV
Sbjct: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTV 466
Query: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFP 481
G L++ VD E Q + A D V ++ V +V I + D ND+ PTFP
Sbjct: 467 TQTGITRYLTLLQP---VDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFP 522
Query: 482 QSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVR 541
+ Y + V G V + A D D G+ G+ITY +L G D F ++ +G +T+
Sbjct: 523 EISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 580
Query: 542 NGELLDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQ 595
G ++ Y LT+QA D +S T+ I +L N+ +P Y++ +
Sbjct: 581 PG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 638
Query: 596 E--EEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI 653
E G V + +QA D + + + + G F+L TG+L LDRE+
Sbjct: 639 EAMRVGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 693
Query: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVL 712
D R +L + SD G P + V I V D+NDN P+F+ N +V EE+
Sbjct: 694 D-----RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 747
Query: 713 VGVVKAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYET 770
VG VKA D D N ++ +SL G+ N F I G + A V L+ E
Sbjct: 748 VGQVKATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREV 793
Query: 771 QPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAV 830
+ + L V A + + + + + V D++DN P S + V EN +
Sbjct: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQ 852
Query: 831 VVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD-- 888
+ A DVD A + + + S F + ++ +++DYEA
Sbjct: 853 IEAKDVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 889 --LVTLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLP 944
+T +V A D+ PG ++ + ++D+ND P F ++ P+ V
Sbjct: 901 EASITFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-K 953
Query: 945 NREVASVRARDDD 957
+ +V A D D
Sbjct: 954 GTPITTVYAEDAD 966
Score = 166 bits (421), Expect = 1e-40
Identities = 324/1314 (24%), Positives = 517/1314 (39%), Gaps = 193/1314 (14%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401
Query: 126 NTAFSTSINETLPVGSVV---------FSVLAVDKDMGSAGMVVYSIEKVIPS---TGDS 173
++ I E+ PVG+ + ++A+DKD IE V PS T D
Sbjct: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDVPPSGVPTKDP 451
Query: 174 E-HLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVF 226
E HLF L + + V + + + Y L+ D TF+I Q S PV
Sbjct: 452 ELHLF--LNDYTSVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI 506
Query: 227 LSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRP 286
++I V+D D P F Y V D G SV+ + AVD D+G N + Y I
Sbjct: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----- 561
Query: 287 GWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDV 346
+GA G +N + L+ V++ V T +TV+ D
Sbjct: 562 ----VGAQGDFIINKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD- 599
Query: 347 NDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLL 406
N E N CT E N + PR P L + + G LL
Sbjct: 600 NAPPAERRN---SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLL 648
Query: 407 SLGGPDAEAFSVS-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ 459
+L D E S++ P+R + ++ + +D E + + A+D
Sbjct: 649 NLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 708
Query: 460 NFSVAMVTIHLRDINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITY 518
S A V I + D+ND+ P F P L+V E A V + ATDPD G GQ+ Y
Sbjct: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHY 766
Query: 519 SLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHL 576
SL GN +LF+ ++ ++ L+RE + Y L + ATDG S+ TL I +
Sbjct: 767 SL--GNFNNLFR---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 821
Query: 577 LDINDNAPVVSGS-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNF 633
LDI+DN+PV + S Y + V+E G + I+A D D G N S + + H F
Sbjct: 822 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFF 877
Query: 634 SLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLP 693
+L P TG L L LD EA P E I V D + VT+ V+D+ND P
Sbjct: 878 ALHPFTGELSLLRSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP 936
Query: 694 IFNQSSYNFTVKEED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGL 747
+F++ Y V + G + V A DAD + R+ A+ F +
Sbjct: 937 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE-- 994
Query: 748 VLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP-- 805
E R+ V+L+ E +F L V A + GE ++ VK + +P
Sbjct: 995 -------EDSGRVITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGE 1043
Query: 806 -PTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWG 864
P R V+E ++ V V+ A+ ++ S I N T G++
Sbjct: 1044 IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN------- 1095
Query: 865 WFSVAANGSVYINQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDV 921
G +Y+N +DYE L V+A L + + SN + I I+D
Sbjct: 1096 ----NITGVIYVN--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1149
Query: 922 NDNAPYFLPENKTFVI--IPELVLPNREVASVRARDDDSGNNGVILFSILRVDF-ISKDG 978
N++ P F K F I + E V V+A D D+GN V+ + ++ K+G
Sbjct: 1150 NNHPPVF---QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1206
Query: 979 ATI-PFQGVFS---IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR-------PS 1027
+ + G+ +F + F + L G V V ++ +
Sbjct: 1207 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
Query: 1028 LGPFL------EATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATR--TTV 1079
+ P L + T L+ + +Q +++ E +GA R +L T+ TV
Sbjct: 1267 VPPTLVEKKIEDLTEILDRYVQEQIPGAKVVV----ESIGARRHGDAFSLEDYTKCDLTV 1322
Query: 1080 YIVDIQDIDSAARARPHSYLDAYFVFPNGSALTL--DELSVMIRNDQDSLTQLLQLGLVV 1137
Y +D Q + R +LD + N + ++ +++T + + G
Sbjct: 1323 YAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRG-ES 1381
Query: 1138 LGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKT 1197
LG E L +II + +LV+++ F VR++ K ++AA A K
Sbjct: 1382 LGYTEG----ALLALAFIIILCCIPAILVVLVSYRQFK-VRQAECTKTARIQAALPAAKP 1436
Query: 1198 A-------AGVMPSAPAIPGTNMYNTERANPM--LNLPNKDLGLEYLSPSNDLDSVSVNS 1248
A A P P PG ++Y + M +P L P+ + V
Sbjct: 1437 AVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEV-- 1494
Query: 1249 LDDNSVDVDKNSQEIKEHRPPHTP-PEPDPEPLSVVLLGRQAGASGQLEGPSYT 1301
+ + + ++ +E K+ + P EP E VV + + A P+YT
Sbjct: 1495 VGEAEEEYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAE-----PTYT 1543
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 685
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 686 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 745
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 746 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 797
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 798 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 848
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 849 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 906
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 907 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 961
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 962 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 1004
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 1005 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1058
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1059 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1112
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1113 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1172
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1173 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1232
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1233 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1287
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1288 QEQIPGAKVVV 1298
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 828 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 887
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 888 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 947
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 948 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 1002
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 1003 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1050
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1051 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1106
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1107 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1156
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1157 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1206
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1207 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1245
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 172 bits (435), Expect = 2e-42
Identities = 221/884 (25%), Positives = 376/884 (42%), Gaps = 105/884 (11%)
Query: 10 LLPALVVSVAANVAPKFLANMTSVI--LPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA 67
LLP++++++ +AP + T V+ +PE+ P L A+ D A
Sbjct: 38 LLPSMLLALLLLLAPS-PGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA 96
Query: 68 YFFAVTPKTGEV-KLASALDYETLYT-----------FKVTISVSDPYIQVQREML---V 112
+ V KTG++ +++D E L + +S++D +L +
Sbjct: 97 PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156
Query: 113 IVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGD 172
V+D NDN P F + + +I E +GS+ LA D+D G G+ Y ++ + +
Sbjct: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ----AGPE 212
Query: 173 SEHLFRILA-------NGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPV 225
++ LF + +++ G+L + Y L +K D G + +
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSAL------ 265
Query: 226 FLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTR 285
L ++V+D D P+F R Y A ++E++ G SV+ V+A D D+G N + Y+ +
Sbjct: 266 -LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 286 PGWFDIGAD---GVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVR 342
+ D G+I V G +DRE L ++ V A + N A+ V V
Sbjct: 325 VVRRLLRLDRNTGLITVQGPVDREDL----STLRFSVLAKDRGTNPKSARAQ----VVVT 376
Query: 343 VMDVNDHKP--EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGS 400
V D+ND+ P E L T ++ N + V E + + + V D D+G
Sbjct: 377 VKDMNDNAPTIEIRGIGL----VTHQDGMANISEDVAEETAVAL------VQVSDRDEGE 426
Query: 401 NGTFLLSLGGPDAEAFSVSPERAAGSAS-VQVLVRVSALVDYERQTAMAVQVVATDSVSQ 459
N + G F + GS S + ++ + +DYE+ +++VA DS +
Sbjct: 427 NAAVTCVVAGD--VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP 484
Query: 460 NF-SVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITY 518
S + + + D+ND+ P F QS+ + PE++ G V+ + I A+D D+G+ ++ Y
Sbjct: 485 PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE-ITASDADSGSNAELVY 543
Query: 519 SLLPGNGA-DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIH 575
SL P A LF + P +G + V+ LDRE + Y L + A D G +L + T+ ++
Sbjct: 544 SLEPEPAAKGLFTISPETGEIQVKTS--LDREQRESYELKVVAADRGSPSLQGTATVLVN 601
Query: 576 LLDINDNAP--VVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNF 633
+LD NDN P ++SG YN V E +S D N+++ ++ + +F
Sbjct: 602 VLDCNDNDPKFMLSG-YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD--NGDF 658
Query: 634 SLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLP 693
+ TG + + DRE + + D G P V VTI V D NDN P
Sbjct: 659 VIQNGTGTILSSLSFDREQ-----QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
Query: 694 IF---NQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLG 750
+ +S+ + G V V A D D + N + +S++G G Y + +
Sbjct: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAG-GNPYGLFQ----- 766
Query: 751 AGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVN-------- 802
G G + L ++ + + VS P+ G +V + VN N
Sbjct: 767 IGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLL 826
Query: 803 ----DNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
D P +D+A G E Q G + V + V A L
Sbjct: 827 GHSLDTPLDIDIA---GDPEYERSKQRGNILFGVVAGVVAVALL 867
Score = 142 bits (358), Expect = 2e-33
Identities = 195/765 (25%), Positives = 301/765 (39%), Gaps = 122/765 (15%)
Query: 302 SLDREQLLEADEEVQLQVTATETHLNIYGQEAKVS---IWVTVRVMDVNDHKPEFYNCSL 358
S+DRE L E ++ E ++I S + + V D+ND+ P F +
Sbjct: 114 SIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFAS--- 170
Query: 359 PACTFT-PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDA-EA 415
P T PE + PI + D D G NG L GP+A E
Sbjct: 171 PVITLAIPENTNIGSL----------FPIP----LASDRDAGPNGVASYELQAGPEAQEL 216
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ-NFSVAMVTIHLRDIN 474
F + Q++V + +D ER + + + D S S A++ + + D N
Sbjct: 217 FGLQVAEDQEEKQPQLIVMGN--LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 475 DHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSL--LPGNGADLFQVD 532
D+ P F + Y + E+S G V + A D D GA +I Y+ P L ++D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQ-VKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 533 PVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL--DINDNAPVVS--- 587
+G +TV+ +DRE + ++ A D G S Q+ + D+NDNAP +
Sbjct: 334 RNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 588 --------GSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDT 639
G NI E +Q D DE + + ++ G +T
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDE---GENAAVTCVVAGDVPFQLRQASET 448
Query: 640 G-------LLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNL 692
G L+ PLD E + + ++ D G P L + ++ + V D+NDN
Sbjct: 449 GSDSKKKYFLQTTTPLDYEKVKD-----YTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 693 PIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGA 751
P+F QS E + PG ++ + A DAD + +N + +SL A
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVYSLEPEPA------------ 550
Query: 752 GWAEGYLRLPPDV-------SLDYETQPVFNLTVSAEN---PDPQGGETIVDVCVNVKDV 801
A+G + P+ SLD E + + L V A + P QG T++ VNV D
Sbjct: 551 --AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL---VNVLDC 605
Query: 802 NDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSL 861
NDN P ++ V EN V +V D D ++QL D G
Sbjct: 606 NDNDPKFMLSGYN-FSVMENMPALSPVGMVTVIDGDKGENAQVQL------SVEQDNGDF 658
Query: 862 CWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDV 921
V NG+ I S + D E T ++A D P AY + I + D
Sbjct: 659 ------VIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR-SAYVG---VTINVLDE 708
Query: 922 NDNAPYF-LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGAT 980
NDNAPY P N + ++ V+ V A D DSG N +++SI
Sbjct: 709 NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI---------AGG 759
Query: 981 IPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR 1025
P+ G+F I + S G+I ++ G +++ V+ DR
Sbjct: 760 NPY-GLFQIGSHS------GAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 129 bits (323), Expect = 2e-29
Identities = 177/711 (24%), Positives = 285/711 (40%), Gaps = 97/711 (13%)
Query: 229 ISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPG- 287
I V D D P F + ++ E+ G+ A D D G N Y +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 288 --WFDIGADGVIR-----VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVT 340
+ D + V G+LDRE+ D +++Q + + S +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS--------SALLR 267
Query: 341 VRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVY--DPDK 398
V V+D ND+ P+F S A S PI + V D D+
Sbjct: 268 VTVLDTNDNAPKFERPSYEA------------------ELSENSPIGHSVIQVKANDSDQ 309
Query: 399 GSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV 457
G+N + P+ + +R G L+ V VD E + + V+A D
Sbjct: 310 GANAEIEYTFHQAPEVVRRLLRLDRNTG------LITVQGPVDREDLSTLRFSVLAKDRG 363
Query: 458 SQNFSV-AMVTIHLRDINDHRPTFP-QSLYVLTVPEHSATGS------VVTDSIHATDPD 509
+ S A V + ++D+ND+ PT + + ++T + A S + +D D
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 510 TGAWGQITYSLLPGNGADLFQVDPVSGTVT-------VRNGELLDRESQAVYYLTLQATD 562
G +T + G FQ+ S T + ++ LD E Y + + A D
Sbjct: 424 EGENAAVTCVVA---GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480
Query: 563 GGN--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNN 617
GN LSS+ +L++ ++D+NDNAPV + S E G V I A D D +N
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG--SN 538
Query: 618 SRLLFNLLPGPYSHN-FSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
+ L+++L P P + F++ P+TG ++ LDRE + L V+ +D G P L
Sbjct: 539 AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRES-----YELKVVAADRGSPSLQ 593
Query: 677 TKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL-VGVVKAWDADQTEANNRISFSLS 735
V + V D NDN P F S YNF+V E P + VG+V D D+ E N ++ S+
Sbjct: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGE-NAQVQLSVE 652
Query: 736 GSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVC 795
++ + G + +S D E Q + + A + V V
Sbjct: 653 QDNGDFVI----------QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702
Query: 796 VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQ-VAVVVASDVDTSAQLEIQLVNILCTKA 854
+NV D NDN P + S ++ ++ G+ V+ V A D D+ E+ + +I
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAEL-IYSI----- 756
Query: 855 GVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF 905
G +G F + ++ I K I+ L LVV+ D P +
Sbjct: 757 ---AGGNPYGLFQIGSHSGA-ITLEKEIERRHHGLHRLVVKVSDRGKPPRY 803
Score = 119 bits (298), Expect = 2e-26
Identities = 140/496 (28%), Positives = 207/496 (41%), Gaps = 70/496 (14%)
Query: 573 QIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAH-DNDEPGTNNSRLLFNLLPGPYSH 631
QI + DINDN P + E N+ +D N + L GP +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 632 N-FSL------DPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTIT 684
F L + L +G LDRE D LT+ V D G P + + +T
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-----YDLTIKVQDGGSPPRASSALLRVT 269
Query: 685 VEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFM 743
V D NDN P F + SY + E P G V VKA D+DQ AN I ++ + +
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQG-ANAEIEYTFHQAPE---V 325
Query: 744 IRGLVLGAGWAEGYLRLPPDVSL-------DYETQPVFNLTVSAENPDPQGGETIVDVCV 796
+R L LRL + L D E +V A++ V V
Sbjct: 326 VRRL----------LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375
Query: 797 NVKDVNDNPPTLDVASLRGI-------RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNI 849
VKD+NDN PT+++ + + ++E+ ++ VA+V SD D E + +
Sbjct: 376 TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD-----EGENAAV 430
Query: 850 LCTKAGVDVGSLCWGWFSVAANGSVYINQSKA-IDYEACDLVTLVVRACDLATDPGFQAY 908
C AG L + + + Y Q+ +DYE T+ + +A D G
Sbjct: 431 TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEI----VAVDSGNPPL 486
Query: 909 SNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
S+ SL + + DVNDNAP F ++ T V PE P +A + A D DSG+N +++S+
Sbjct: 487 SSTNSLKVQVVDVNDNAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545
Query: 969 LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSL 1028
P +FT S G IQ TSLD + +Y++ V A DR S
Sbjct: 546 ------------EPEPAAKGLFTISPE---TGEIQVKTSLDREQRESYELKVVAADRGS- 589
Query: 1029 GPFLEATTTLNLFTVD 1044
P L+ T T+ + +D
Sbjct: 590 -PSLQGTATVLVNVLD 604
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 172 bits (435), Expect = 2e-42
Identities = 221/884 (25%), Positives = 376/884 (42%), Gaps = 105/884 (11%)
Query: 10 LLPALVVSVAANVAPKFLANMTSVI--LPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA 67
LLP++++++ +AP + T V+ +PE+ P L A+ D A
Sbjct: 38 LLPSMLLALLLLLAPS-PGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA 96
Query: 68 YFFAVTPKTGEV-KLASALDYETLYT-----------FKVTISVSDPYIQVQREML---V 112
+ V KTG++ +++D E L + +S++D +L +
Sbjct: 97 PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156
Query: 113 IVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGD 172
V+D NDN P F + + +I E +GS+ LA D+D G G+ Y ++ + +
Sbjct: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ----AGPE 212
Query: 173 SEHLFRILA-------NGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPV 225
++ LF + +++ G+L + Y L +K D G + +
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSAL------ 265
Query: 226 FLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTR 285
L ++V+D D P+F R Y A ++E++ G SV+ V+A D D+G N + Y+ +
Sbjct: 266 -LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 286 PGWFDIGAD---GVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVR 342
+ D G+I V G +DRE L ++ V A + N A+ V V
Sbjct: 325 VVRRLLRLDRNTGLITVQGPVDREDL----STLRFSVLAKDRGTNPKSARAQ----VVVT 376
Query: 343 VMDVNDHKP--EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGS 400
V D+ND+ P E L T ++ N + V E + + + V D D+G
Sbjct: 377 VKDMNDNAPTIEIRGIGL----VTHQDGMANISEDVAEETAVAL------VQVSDRDEGE 426
Query: 401 NGTFLLSLGGPDAEAFSVSPERAAGSAS-VQVLVRVSALVDYERQTAMAVQVVATDSVSQ 459
N + G F + GS S + ++ + +DYE+ +++VA DS +
Sbjct: 427 NAAVTCVVAGD--VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP 484
Query: 460 NF-SVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITY 518
S + + + D+ND+ P F QS+ + PE++ G V+ + I A+D D+G+ ++ Y
Sbjct: 485 PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE-ITASDADSGSNAELVY 543
Query: 519 SLLPGNGA-DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIH 575
SL P A LF + P +G + V+ LDRE + Y L + A D G +L + T+ ++
Sbjct: 544 SLEPEPAAKGLFTISPETGEIQVKTS--LDREQRESYELKVVAADRGSPSLQGTATVLVN 601
Query: 576 LLDINDNAP--VVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNF 633
+LD NDN P ++SG YN V E +S D N+++ ++ + +F
Sbjct: 602 VLDCNDNDPKFMLSG-YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD--NGDF 658
Query: 634 SLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLP 693
+ TG + + DRE + + D G P V VTI V D NDN P
Sbjct: 659 VIQNGTGTILSSLSFDREQ-----QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
Query: 694 IF---NQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLG 750
+ +S+ + G V V A D D + N + +S++G G Y + +
Sbjct: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAG-GNPYGLFQ----- 766
Query: 751 AGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVN-------- 802
G G + L ++ + + VS P+ G +V + VN N
Sbjct: 767 IGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLL 826
Query: 803 ----DNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
D P +D+A G E Q G + V + V A L
Sbjct: 827 GHSLDTPLDIDIA---GDPEYERSKQRGNILFGVVAGVVAVALL 867
Score = 142 bits (358), Expect = 2e-33
Identities = 195/765 (25%), Positives = 301/765 (39%), Gaps = 122/765 (15%)
Query: 302 SLDREQLLEADEEVQLQVTATETHLNIYGQEAKVS---IWVTVRVMDVNDHKPEFYNCSL 358
S+DRE L E ++ E ++I S + + V D+ND+ P F +
Sbjct: 114 SIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFAS--- 170
Query: 359 PACTFT-PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDA-EA 415
P T PE + PI + D D G NG L GP+A E
Sbjct: 171 PVITLAIPENTNIGSL----------FPIP----LASDRDAGPNGVASYELQAGPEAQEL 216
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQ-NFSVAMVTIHLRDIN 474
F + Q++V + +D ER + + + D S S A++ + + D N
Sbjct: 217 FGLQVAEDQEEKQPQLIVMGN--LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 475 DHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSL--LPGNGADLFQVD 532
D+ P F + Y + E+S G V + A D D GA +I Y+ P L ++D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQ-VKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 533 PVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLL--DINDNAPVVS--- 587
+G +TV+ +DRE + ++ A D G S Q+ + D+NDNAP +
Sbjct: 334 RNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 588 --------GSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDT 639
G NI E +Q D DE + + ++ G +T
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDE---GENAAVTCVVAGDVPFQLRQASET 448
Query: 640 G-------LLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNL 692
G L+ PLD E + + ++ D G P L + ++ + V D+NDN
Sbjct: 449 GSDSKKKYFLQTTTPLDYEKVKD-----YTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 693 PIFNQSSYNFTVKEED-PGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGA 751
P+F QS E + PG ++ + A DAD + +N + +SL A
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVYSLEPEPA------------ 550
Query: 752 GWAEGYLRLPPDV-------SLDYETQPVFNLTVSAEN---PDPQGGETIVDVCVNVKDV 801
A+G + P+ SLD E + + L V A + P QG T++ VNV D
Sbjct: 551 --AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL---VNVLDC 605
Query: 802 NDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSL 861
NDN P ++ V EN V +V D D ++QL D G
Sbjct: 606 NDNDPKFMLSGYN-FSVMENMPALSPVGMVTVIDGDKGENAQVQL------SVEQDNGDF 658
Query: 862 CWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDV 921
V NG+ I S + D E T ++A D P AY + I + D
Sbjct: 659 ------VIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR-SAYVG---VTINVLDE 708
Query: 922 NDNAPYF-LPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGAT 980
NDNAPY P N + ++ V+ V A D DSG N +++SI
Sbjct: 709 NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI---------AGG 759
Query: 981 IPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR 1025
P+ G+F I + S G+I ++ G +++ V+ DR
Sbjct: 760 NPY-GLFQIGSHS------GAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 129 bits (323), Expect = 2e-29
Identities = 177/711 (24%), Positives = 285/711 (40%), Gaps = 97/711 (13%)
Query: 229 ISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPG- 287
I V D D P F + ++ E+ G+ A D D G N Y +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 288 --WFDIGADGVIR-----VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVT 340
+ D + V G+LDRE+ D +++Q + + S +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS--------SALLR 267
Query: 341 VRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVY--DPDK 398
V V+D ND+ P+F S A S PI + V D D+
Sbjct: 268 VTVLDTNDNAPKFERPSYEA------------------ELSENSPIGHSVIQVKANDSDQ 309
Query: 399 GSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV 457
G+N + P+ + +R G L+ V VD E + + V+A D
Sbjct: 310 GANAEIEYTFHQAPEVVRRLLRLDRNTG------LITVQGPVDREDLSTLRFSVLAKDRG 363
Query: 458 SQNFSV-AMVTIHLRDINDHRPTFP-QSLYVLTVPEHSATGS------VVTDSIHATDPD 509
+ S A V + ++D+ND+ PT + + ++T + A S + +D D
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 510 TGAWGQITYSLLPGNGADLFQVDPVSGTVT-------VRNGELLDRESQAVYYLTLQATD 562
G +T + G FQ+ S T + ++ LD E Y + + A D
Sbjct: 424 EGENAAVTCVVA---GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480
Query: 563 GGN--LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNN 617
GN LSS+ +L++ ++D+NDNAPV + S E G V I A D D +N
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG--SN 538
Query: 618 SRLLFNLLPGPYSHN-FSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
+ L+++L P P + F++ P+TG ++ LDRE + L V+ +D G P L
Sbjct: 539 AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRES-----YELKVVAADRGSPSLQ 593
Query: 677 TKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVL-VGVVKAWDADQTEANNRISFSLS 735
V + V D NDN P F S YNF+V E P + VG+V D D+ E N ++ S+
Sbjct: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGE-NAQVQLSVE 652
Query: 736 GSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVC 795
++ + G + +S D E Q + + A + V V
Sbjct: 653 QDNGDFVI----------QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702
Query: 796 VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQ-VAVVVASDVDTSAQLEIQLVNILCTKA 854
+NV D NDN P + S ++ ++ G+ V+ V A D D+ E+ + +I
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAEL-IYSI----- 756
Query: 855 GVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF 905
G +G F + ++ I K I+ L LVV+ D P +
Sbjct: 757 ---AGGNPYGLFQIGSHSGA-ITLEKEIERRHHGLHRLVVKVSDRGKPPRY 803
Score = 119 bits (298), Expect = 2e-26
Identities = 140/496 (28%), Positives = 207/496 (41%), Gaps = 70/496 (14%)
Query: 573 QIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAH-DNDEPGTNNSRLLFNLLPGPYSH 631
QI + DINDN P + E N+ +D N + L GP +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 632 N-FSL------DPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTIT 684
F L + L +G LDRE D LT+ V D G P + + +T
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-----YDLTIKVQDGGSPPRASSALLRVT 269
Query: 685 VEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYFM 743
V D NDN P F + SY + E P G V VKA D+DQ AN I ++ + +
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQG-ANAEIEYTFHQAPE---V 325
Query: 744 IRGLVLGAGWAEGYLRLPPDVSL-------DYETQPVFNLTVSAENPDPQGGETIVDVCV 796
+R L LRL + L D E +V A++ V V
Sbjct: 326 VRRL----------LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375
Query: 797 NVKDVNDNPPTLDVASLRGI-------RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNI 849
VKD+NDN PT+++ + + ++E+ ++ VA+V SD D E + +
Sbjct: 376 TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD-----EGENAAV 430
Query: 850 LCTKAGVDVGSLCWGWFSVAANGSVYINQSKA-IDYEACDLVTLVVRACDLATDPGFQAY 908
C AG L + + + Y Q+ +DYE T+ + +A D G
Sbjct: 431 TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEI----VAVDSGNPPL 486
Query: 909 SNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSI 968
S+ SL + + DVNDNAP F ++ T V PE P +A + A D DSG+N +++S+
Sbjct: 487 SSTNSLKVQVVDVNDNAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545
Query: 969 LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSL 1028
P +FT S G IQ TSLD + +Y++ V A DR S
Sbjct: 546 ------------EPEPAAKGLFTISPE---TGEIQVKTSLDREQRESYELKVVAADRGS- 589
Query: 1029 GPFLEATTTLNLFTVD 1044
P L+ T T+ + +D
Sbjct: 590 -PSLQGTATVLVNVLD 604
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo
sapiens]
Length = 1955
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 129 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 189 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 248 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 299
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 360 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 401
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 455
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 456 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 514
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 515 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 570
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 631 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 682
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 683 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 739
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 740 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 785
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 844
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 845 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 893 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 945
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 946 TTVYAEDAD 954
Score = 167 bits (424), Expect = 5e-41
Identities = 313/1268 (24%), Positives = 504/1268 (39%), Gaps = 173/1268 (13%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 397 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 449
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 450 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 557
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 558 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 596
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 597 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 765 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 877
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 878 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 936
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 937 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 987
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1043
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1044 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1091
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1092 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1146
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSILRVDF-ISKDGATI-PFQGVFS- 988
F I + E V V+A D D+GN V+ + ++ K+G + + G+
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Query: 989 --IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR-------PSLGPFL------E 1033
+F + F + L G V V ++ ++ P L +
Sbjct: 1207 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIED 1266
Query: 1034 ATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATR--TTVYIVDIQDIDSAA 1091
T L+ + +Q +++ E +GA R +L T+ TVY +D Q +
Sbjct: 1267 LTEILDRYVQEQIPGAKVVV----ESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1322
Query: 1092 RARPHSYLDAYFVFPNGSALTL--DELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLS 1149
R +LD + N + ++ +++T + + G LG E
Sbjct: 1323 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRG-ESLGYTEG----AL 1377
Query: 1150 KQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTA-------AGVM 1202
L +II + +LV+++ F VR++ K ++AA A K A A
Sbjct: 1378 LALAFIIILCCIPAILVVLVSYRQFK-VRQAECTKTARIQAALPAAKPAVPAPAPVAAPP 1436
Query: 1203 PSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQE 1262
P P PG ++Y + +L L L + S +SVS V + +S
Sbjct: 1437 PPPPPPPGAHLYEELGDSSILFL------LYHFQQSRGNNSVS-EDRKHQQVVMPFSSNT 1489
Query: 1263 IKEHRPPH 1270
I+ H+ H
Sbjct: 1490 IEAHKSAH 1497
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 614 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 673
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 674 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 733
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 785
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 786 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 837 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 895 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 949
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 950 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 992
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 993 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1046
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1047 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1100
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1101 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1160
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1275
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1276 QEQIPGAKVVV 1286
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 875
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 876 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 990
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 991 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1038
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1039 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1095 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1144
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1145 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1194
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1195 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo
sapiens]
Length = 1932
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 107 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 167 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 226 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 277
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 278 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 337
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 338 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 379
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 380 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 433
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 434 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 492
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 493 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 548
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 609 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 660
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 661 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 717
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 718 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 763
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 764 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 822
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 823 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 871 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 923
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 924 TTVYAEDAD 932
Score = 169 bits (427), Expect = 2e-41
Identities = 312/1263 (24%), Positives = 497/1263 (39%), Gaps = 164/1263 (12%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 375 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 427
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 428 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 484
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 535
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 536 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 574
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 575 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 626
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 686
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 687 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 742
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 743 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 800 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 855
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 856 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 914
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 915 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 965
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1021
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1022 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1069
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1070 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1124
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSILRVDF-ISKDGATI-PFQGVFS- 988
F I + E V V+A D D+GN V+ + ++ K+G + + G+
Sbjct: 1125 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Query: 989 --IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR-------PSLGPFL------E 1033
+F + F + L G V V ++ ++ P L +
Sbjct: 1185 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIED 1244
Query: 1034 ATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATR--TTVYIVDIQDIDSAA 1091
T L+ + +Q +++ E +GA R +L T+ TVY +D Q +
Sbjct: 1245 LTEILDRYVQEQIPGAKVVV----ESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1300
Query: 1092 RARPHSYLDAYFVFPNGSALTL--DELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLS 1149
R +LD + N + ++ +++T + + G S E L
Sbjct: 1301 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRG----ESLGYTEGALL 1356
Query: 1150 KQLISVIIGLGVALLLVLVIMTMAFVCVRKS--YNRKLQAMKAAKEARKTAAGVMPSAPA 1207
+I+ A+L+VLV K+ L A K A A A P P
Sbjct: 1357 ALAFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPP 1416
Query: 1208 IPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHR 1267
PG ++Y + M NL L + S +SVS V + +S I+ H+
Sbjct: 1417 PPGAHLYEELGDSSMHNL----FLLYHFQQSRGNNSVS-EDRKHQQVVMPFSSNTIEAHK 1471
Query: 1268 PPH 1270
H
Sbjct: 1472 SAH 1474
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 592 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 651
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 652 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 711
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 712 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 763
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 764 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 814
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 815 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 873 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 927
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 928 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 970
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 971 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1024
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1025 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1078
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1079 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1138
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1139 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1253
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1254 QEQIPGAKVVV 1264
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 794 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 853
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 854 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 913
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 914 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 968
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 969 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1016
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1017 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1072
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1073 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1122
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1123 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1172
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1173 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 93 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 139
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
Length = 1677
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 129 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 189 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 248 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 299
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 360 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 401
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 455
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 456 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 514
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 515 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 570
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 631 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 682
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 683 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 739
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 740 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 785
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 844
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 845 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 893 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 945
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 946 TTVYAEDAD 954
Score = 166 bits (421), Expect = 1e-40
Identities = 247/938 (26%), Positives = 385/938 (41%), Gaps = 127/938 (13%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 397 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 449
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 450 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 557
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 558 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 596
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 597 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 765 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 877
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 878 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 936
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 937 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 987
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1043
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1044 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1091
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1092 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1146
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSIL 969
F I + E V V+A D D+GN V+ + ++
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 614 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 673
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 674 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 733
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 785
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 786 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 837 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 895 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 949
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 950 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 992
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 993 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1046
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1047 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1100
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1101 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1160
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1275
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1276 QEQIPGAKVVV 1286
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 875
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 876 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 990
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 991 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1038
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1039 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1095 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1144
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1145 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1194
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1195 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo
sapiens]
Length = 1682
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 134 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 193
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 194 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 253 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 304
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 305 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 364
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 365 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 406
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 460
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 461 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 519
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 520 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 575
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 576 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 635
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 636 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 687
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 688 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 744
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 745 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 790
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 791 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 849
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 850 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 898 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 950
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 951 TTVYAEDAD 959
Score = 166 bits (421), Expect = 1e-40
Identities = 247/938 (26%), Positives = 385/938 (41%), Gaps = 127/938 (13%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 402 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 454
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 455 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 511
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 512 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 562
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 563 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 601
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 602 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 653
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 654 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 713
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 714 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 769
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 770 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 826
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 827 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 882
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 883 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 941
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 942 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 992
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 993 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1048
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1049 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1096
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1097 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1151
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSIL 969
F I + E V V+A D D+GN V+ + ++
Sbjct: 1152 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 619 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 678
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 679 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 738
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 739 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 790
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 791 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 841
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 842 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 899
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 900 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 954
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 955 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 997
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 998 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1051
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1052 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1105
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1106 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1165
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1166 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1225
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1226 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1280
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1281 QEQIPGAKVVV 1291
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 821 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 880
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 881 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 940
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 941 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 995
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 996 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1043
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1044 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1099
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1100 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1149
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1150 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1199
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1200 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1238
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo
sapiens]
Length = 1539
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 129 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 189 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 248 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 299
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 360 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 401
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 455
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 456 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 514
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 515 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 570
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 631 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 682
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 683 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 739
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 740 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 785
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 844
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 845 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 893 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 945
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 946 TTVYAEDAD 954
Score = 166 bits (421), Expect = 1e-40
Identities = 247/938 (26%), Positives = 385/938 (41%), Gaps = 127/938 (13%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 397 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 449
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 450 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 557
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 558 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 596
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 597 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 765 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 877
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 878 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 936
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 937 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 987
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1043
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1044 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1091
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1092 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1146
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSIL 969
F I + E V V+A D D+GN V+ + ++
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 614 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 673
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 674 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 733
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 785
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 786 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 837 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 895 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 949
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 950 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 992
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 993 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1046
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1047 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1100
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1101 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1160
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1275
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1276 QEQIPGAKVVV 1286
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 875
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 876 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 990
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 991 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1038
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1039 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1095 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1144
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1145 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1194
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1195 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo
sapiens]
Length = 1935
Score = 171 bits (433), Expect = 4e-42
Identities = 228/909 (25%), Positives = 377/909 (41%), Gaps = 140/909 (15%)
Query: 106 VQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL-----AVDKDMGSAGMVV 160
+ E+ ++V DRNDN+P F++ ++ ++NE PVG+ +F+ A D D G G +
Sbjct: 107 IYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
Query: 161 YSIEKVIPSTGDSEHLFRI--LANGSIVLNGSLSYNNKSAFY---QLELKACDLGGMYHN 215
Y I+ P S F I + G+IVL L+Y +K+ ++ Q +A +L
Sbjct: 167 YVIQ-YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 216 TFTIQCSLPVFLSISVVDQPDLDPQFV--------RE----FYSASVAE---DAAKGTSV 260
T T L++ V+D DL P F+ R+ Y A++ E +
Sbjct: 226 TTT--------LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 277
Query: 261 LT--VEAVDGDKGINDP-----VIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADE 313
+T ++A+D D+ I P ++YSI T + SL + +
Sbjct: 278 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 337
Query: 314 EVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFT 373
+ L + A + + G + + ++D N+ P F ++P ++
Sbjct: 338 KFDLVIKAEQDN----GHPLPAFAGLHIEILDENNQSPYF---TMP-----------SYQ 379
Query: 374 GYVDEHASPRIPIDD-------LTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAAG 425
GY+ E A I D L +V D D L L D F+V+
Sbjct: 380 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT------ 433
Query: 426 SASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLY 485
+ + + VD E Q + A D V ++ V +V I + D ND+ PTFP+ Y
Sbjct: 434 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVNIQVMDANDNTPTFPEISY 492
Query: 486 VLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGEL 545
+ V G V + A D D G+ G+ITY +L G D F ++ +G +T+ G
Sbjct: 493 DVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPG-- 548
Query: 546 LDRESQAVYYLTLQATDGG----NLSSSTTLQIHLLDINDNAP--VVSGSYNIFVQE--E 597
++ Y LT+QA D +S T+ I +L N+ +P Y++ + E
Sbjct: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 598 EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPAL 657
G V + +QA D + + + + G F+L TG+L LDRE+ D
Sbjct: 609 VGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD--- 660
Query: 658 EGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFN-QSSYNFTVKEEDPGVLVGVV 716
R +L + SD G P + V I V D+NDN P+F+ N +V EE+ VG V
Sbjct: 661 --RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 717
Query: 717 KAWDADQTEANNRISFSLSGSGANYFMI--RGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
KA D D N ++ +SL G+ N F I G + A V L+ E + +
Sbjct: 718 KATDPD-AGINGQVHYSL-GNFNNLFRITSNGSIYTA------------VKLNREVRDYY 763
Query: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
L V A + + + + + V D++DN P S + V EN + + A
Sbjct: 764 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF-TNSTYTVLVEENLPAGTTILQIEAK 822
Query: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACD----LV 890
DVD A + + + S F + ++ +++DYEA +
Sbjct: 823 DVDLGANVSYR------------IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 891 TLVVRACDL--ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREV 948
T +V A D+ PG ++ + ++D+ND P F ++ P+ V +
Sbjct: 871 TFLVEAFDIYGTMPPGI------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-KGTPI 923
Query: 949 ASVRARDDD 957
+V A D D
Sbjct: 924 TTVYAEDAD 932
Score = 169 bits (428), Expect = 2e-41
Identities = 314/1268 (24%), Positives = 504/1268 (39%), Gaps = 171/1268 (13%)
Query: 69 FFAVTPKTGEVKLASALDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQ 125
FF + P+T E+ L ++ + F + I + + + + D N+ +P F
Sbjct: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374
Query: 126 NTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSE-HLFRILANGS 184
++ I E+ PVG+ + L + ++ + + +++K I T D E HLF L + +
Sbjct: 375 MPSYQGYILESAPVGATISDSLNL-----TSPLRIVALDKDIEDTKDPELHLF--LNDYT 427
Query: 185 IVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI------QCSLPVFLSISVVDQPDLD 238
V + + + Y L+ D TF+I Q S PV ++I V+D D
Sbjct: 428 SVFTVTQTGITR---YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 484
Query: 239 PQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIR 298
P F Y V D G SV+ + AVD D+G N + Y I +GA G
Sbjct: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL---------VGAQGDFI 535
Query: 299 VNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSL 358
+N + L+ V++ V T +TV+ D N E N
Sbjct: 536 INKTTG---LITIAPGVEMIVGRTYA--------------LTVQAAD-NAPPAERRN--- 574
Query: 359 PACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSV 418
CT E N + PR P L + + G LL+L D E S+
Sbjct: 575 SICTVYIEVLPPN------NQSPPRFP--QLMYSLEISEAMRVGAVLLNLQATDREGDSI 626
Query: 419 S-------PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLR 471
+ P+R + ++ + +D E + + A+D S A V I +
Sbjct: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 686
Query: 472 DINDHRPTF-PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
D+ND+ P F P L+V E A V + ATDPD G GQ+ YSL GN +LF+
Sbjct: 687 DVNDNAPVFDPYLPRNLSVVEEEANAFV--GQVKATDPDAGINGQVHYSL--GNFNNLFR 742
Query: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG 588
++ ++ L+RE + Y L + ATDG S+ TL I +LDI+DN+PV +
Sbjct: 743 ---ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
Query: 589 S-YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
S Y + V+E G + I+A D D G N S + + H F+L P TG L L
Sbjct: 800 STYTVLVEENLPAGTTILQIEAKDVD-LGANVS---YRIRSPEVKHFFALHPFTGELSLL 855
Query: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVK 705
LD EA P E I V D + VT+ V+D+ND P+F++ Y V
Sbjct: 856 RSLDYEAF-PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 914
Query: 706 EED-PGVLVGVVKAWDAD-----QTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
+ G + V A DAD + R+ A+ F + E R
Sbjct: 915 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE---------EDSGR 965
Query: 760 LPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNP---PTLDVASLRGI 816
+ V+L+ E +F L V A + GE ++ VK + +P P R
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFD----DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPP 1021
Query: 817 RVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYI 876
V+E ++ V V+ A+ ++ S I N T G++ G +Y+
Sbjct: 1022 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT-FGIN-----------NITGVIYV 1069
Query: 877 NQSKAIDYEACDLVTLVVRACDL---ATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
N +DYE L V+A L + + SN + I I+D N++ P F K
Sbjct: 1070 N--GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF---QK 1124
Query: 934 TFVI--IPELVLPNREVASVRARDDDSGNNGVILFSILRVDF-ISKDGATI-PFQGVFS- 988
F I + E V V+A D D+GN V+ + ++ K+G + + G+
Sbjct: 1125 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Query: 989 --IFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDR-------PSLGPFL------E 1033
+F + F + L G V V ++ ++ P L +
Sbjct: 1185 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIED 1244
Query: 1034 ATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATR--TTVYIVDIQDIDSAA 1091
T L+ + +Q +++ E +GA R +L T+ TVY +D Q +
Sbjct: 1245 LTEILDRYVQEQIPGAKVVV----ESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1300
Query: 1092 RARPHSYLDAYFVFPNGSALTL--DELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLS 1149
R +LD + N + ++ +++T + + G LG E
Sbjct: 1301 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRG-ESLGYTEG----AL 1355
Query: 1150 KQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTA-------AGVM 1202
L +II + +LV+++ F VR++ K ++AA A K A A
Sbjct: 1356 LALAFIIILCCIPAILVVLVSYRQFK-VRQAECTKTARIQAALPAAKPAVPAPAPVAAPP 1414
Query: 1203 PSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQE 1262
P P PG ++Y + M NL L + S +SVS V + +S
Sbjct: 1415 PPPPPPPGAHLYEELGDSSMHNL----FLLYHFQQSRGNNSVS-EDRKHQQVVMPFSSNT 1469
Query: 1263 IKEHRPPH 1270
I+ H+ H
Sbjct: 1470 IEAHKSAH 1477
Score = 135 bits (339), Expect = 3e-31
Identities = 194/731 (26%), Positives = 310/731 (42%), Gaps = 97/731 (13%)
Query: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM-SGPNAYFFAVTPKTGEVKLA 82
P+F M S+ + E + VGA L A D++ D +TY + +G F ++ TG + L
Sbjct: 592 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLG 651
Query: 83 SALDYETLYTFKVTISVSD--PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVG 140
ALD E+ + + I+ SD P + ++V D NDNAPVF
Sbjct: 652 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 711
Query: 141 SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFY 200
+ V V A D D G G V YS+ G+ +LFRI +NGSI L+ + +Y
Sbjct: 712 AFVGQVKATDPDAGINGQVHYSL-------GNFNNLFRITSNGSIYTAVKLNREVRD-YY 763
Query: 201 QLELKACDLGGMY--HNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGT 258
+L + A D G ++ H+T T L+I V+D D P F Y+ V E+ GT
Sbjct: 764 ELVVVATD-GAVHPRHSTLT--------LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 814
Query: 259 SVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNGSLDREQLLEADEEVQL 317
++L +EA D D G N V Y I +F + G + + SLD E + + +
Sbjct: 815 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 318 QVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVN--FTGY 375
V A +IYG VTV V D+ND+ P F + + P+ + T Y
Sbjct: 873 LVEA----FDIYGTMPPGIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTPITTVY 927
Query: 376 VDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV 435
++ P +P + V D + P A F V + S +V+ RV
Sbjct: 928 AEDADPPGLPASRVRYRVDD----------VQFPYP-ASIFEVEED------SGRVITRV 970
Query: 436 SALVDYERQTAMAVQVVATDS----VSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE 491
+ ++ E T + VVA D +S + +V ++ +H +I P F Q Y
Sbjct: 971 N--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVS 1024
Query: 492 HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQ 551
AT + I A + I YS++ GN D F ++ ++G + V NG LD E++
Sbjct: 1025 ELATKGTMVGVISAAAINQ----SIVYSIVSGNEEDTFGINNITGVIYV-NGP-LDYETR 1078
Query: 552 AVYYLTLQATD----GGNL-----SSSTTLQIHLLDINDNAPVVSGSYNI-FVQEEEGNV 601
Y L +QA NL S++ + I + D N++ PV + I V E+
Sbjct: 1079 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1138
Query: 602 SVTIQAHDNDEPGTNNSRLLFNLLPGPY---SHNFSLDPDTGLLR-------------NL 645
+ ++ D+ N S + + L+ P F ++ TGL++
Sbjct: 1139 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 646 GPLDREAIDPALEGRI-VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTV 704
+ + L G+ VL +V+ V+ + V T+ + I D I ++ V
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDR-----YV 1253
Query: 705 KEEDPGVLVGV 715
+E+ PG V V
Sbjct: 1254 QEQIPGAKVVV 1264
Score = 82.8 bits (203), Expect = 2e-15
Identities = 122/467 (26%), Positives = 182/467 (38%), Gaps = 76/467 (16%)
Query: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD-NDPLTYGMSGPNA-YFFAVTPKTGEVK 80
+P F + +V++ E+LP G + A+D D ++Y + P +FFA+ P TGE+
Sbjct: 794 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 853
Query: 81 LASALDYETLYTFKVTISVSDPYIQVQREM-------LVIVEDRNDNAPVFQNTAFSTSI 133
L +LDYE + +I+ + M VIV+D ND PVF + +
Sbjct: 854 LLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 913
Query: 134 NETLPVGSVVFSVLAVDKDMGS--AGMVVYSIEKV---IPSTGDSEHLFRILANGSIVLN 188
G+ + +V A D D A V Y ++ V P++ +F + + V+
Sbjct: 914 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS-----IFEVEEDSGRVIT 968
Query: 189 GSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVD----QPDLDPQFVRE 244
+ ++L + A D G PV S + V P P+F +E
Sbjct: 969 RVNLNEEPTTIFKLVVVAFDDGE------------PVMSSSATVKILVLHPGEIPRFTQE 1016
Query: 245 FY-SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI-GADGVIRVNGS 302
Y V+E A KGT V + A IN ++YSI F I GVI VNG
Sbjct: 1017 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1072
Query: 303 LDREQLLEADEEVQ---LQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLP 359
LD E VQ L+V + AKV I + D N+H P F
Sbjct: 1073 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI----EIQDENNHPPVF------ 1122
Query: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP----DAEA 415
+ + G V E A R+ L + D D G+ L P E
Sbjct: 1123 --------QKKFYIGGVSEDA--RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1172
Query: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFS 462
F V E G L++ + L R++ QV+ATD + S
Sbjct: 1173 FVV--ETYTG------LIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
Score = 30.8 bits (68), Expect = 8.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 665 VLVSDCGEPVLGTKV--NVTITVEDINDNLPIFNQSSYNFTVKEEDP 709
V+ C +GT + V I V D NDN P F SY TV E P
Sbjct: 93 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,340,669
Number of Sequences: 37866
Number of extensions: 2221038
Number of successful extensions: 16081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 6495
Number of HSP's gapped (non-prelim): 1543
length of query: 1310
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1196
effective length of database: 13,930,794
effective search space: 16661229624
effective search space used: 16661229624
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.