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Search of human proteins with 16507964
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
(530 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens] 1067 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 967 0.0
gi|16933559 protocadherin LKC precursor [Homo sapiens] 213 3e-55
gi|16933565 protocadherin 21 precursor [Homo sapiens] 212 8e-55
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 211 1e-54
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 208 1e-53
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 196 6e-50
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 192 5e-49
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 191 2e-48
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 187 2e-47
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 182 9e-46
gi|16933557 dachsous 1 precursor [Homo sapiens] 168 1e-41
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 155 1e-37
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 155 1e-37
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 152 7e-37
gi|14589929 protocadherin 18 precursor [Homo sapiens] 152 1e-36
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 151 1e-36
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 151 1e-36
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 151 1e-36
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 150 3e-36
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 150 3e-36
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 150 3e-36
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 150 3e-36
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 148 1e-35
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 148 1e-35
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 148 1e-35
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 148 1e-35
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 148 1e-35
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 148 1e-35
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 148 1e-35
>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
Length = 530
Score = 1067 bits (2760), Expect = 0.0
Identities = 530/530 (100%), Positives = 530/530 (100%)
Query: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
Query: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 481 TVLVSPRFTAGPLSSPGPTVVRHPEGFCPRDLSNQGRRHPQIPELCLLVY 530
TVLVSPRFTAGPLSSPGPTVVRHPEGFCPRDLSNQGRRHPQIPELCLLVY
Sbjct: 481 TVLVSPRFTAGPLSSPGPTVVRHPEGFCPRDLSNQGRRHPQIPELCLLVY 530
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 967 bits (2501), Expect = 0.0
Identities = 483/485 (99%), Positives = 484/485 (99%)
Query: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
Query: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 481 TVLVS 485
TVL +
Sbjct: 481 TVLAT 485
Score = 192 bits (488), Expect = 6e-49
Identities = 141/465 (30%), Positives = 232/465 (49%), Gaps = 42/465 (9%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQP 92
++ + E+ G++V L A D+D + +++ + G S F + +G +
Sbjct: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEITTTSL 733
Query: 93 LDRETKSEF-----TVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
LDRETKSE+ V+ V +Q VNI + D+NDN PT+ + PY + + E TP
Sbjct: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
Query: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARG-IVTVIRELDYETTQAYQ---- 202
+ + V A DPDLG G+++YS QPP++F++++S G I T LD E ++
Sbjct: 794 DSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELM 853
Query: 203 --LTVNATDQDKTRPLSTLANLAIIIT--DVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
+ V+ TD + PL ++ + + D+ D DP F NLP+ + E P G ++ +
Sbjct: 854 RKIVVSVTDCGRP-PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
AID D+G + Y + G F ++ SGV+ LDRE ++
Sbjct: 913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA----- 967
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
+D TP+ ++ T+T I V+D+ND P F + Y+V+++E F + +++ D D
Sbjct: 968 -SDAGTPTKSS-TSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV-VWLNCTDND- 1023
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVP 438
+GLN+ ++ G N + G D +R + LD ET Y L A ++ P
Sbjct: 1024 -VGLNAELSYFITGGN-----VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
Query: 439 ---DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
H G A V +T+++ NDNRPIF Q Y S+ E++ G S+L
Sbjct: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIL 1122
Score = 158 bits (399), Expect = 1e-38
Identities = 151/472 (31%), Positives = 227/472 (48%), Gaps = 53/472 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFG------VSGEEASRFFAVEPDTGVVWLR-QPLD 94
+ ED P G S+ QL A D D FG + G + F + G++ +PLD
Sbjct: 1111 VPEDIPEGHSILQLKATDADEGE--FGRVWYRILHGNHGNNF-RIHVSNGLLMRGPRPLD 1167
Query: 95 RETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS-VRIPENTPVGTP 150
RE S + +H R +V + V D+ND AP F Q YS + + E +GT
Sbjct: 1168 RERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTS 1227
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
+ +V ATD D G GG V Y ++ F ID + G++ + LDYET +Y + V+ATD
Sbjct: 1228 VIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPI--FINLPYSTNIYEHSPPGTTVRIITAIDQDKGR 267
Q P ++ IT + ++D F N Y I E+ GT + + A D
Sbjct: 1288 Q---APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN 1344
Query: 268 P---RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
R YT S ++F +D I+GV+T+ GL+DRE + + LTV + DD
Sbjct: 1345 QITYRFNAYT--STQAKALFKIDAITGVITVQGLVDREKGDF---YTLTV----VADDGG 1395
Query: 325 PS-DATVTTTFNILVIDINDNAPEFN-SSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
P D+TV I V+D NDN+P F+ +S+ +V+I E VG + V D + G
Sbjct: 1396 PKVDSTVKVY--ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT---VKAWDPDAGS 1450
Query: 383 NSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES----- 436
N L GN + F I T+ + + VA PLD E +D Y + A++
Sbjct: 1451 NGQVVFSLASGNIAGAFEIVTTN---DSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPL-YNISLYENVTVGTSVLTVLVSPR 487
DH+ +++T+++ NDN P+ P YN+S+ ENV GT+V+ V + R
Sbjct: 1508 KKDHI----LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
Score = 158 bits (399), Expect = 1e-38
Identities = 148/483 (30%), Positives = 229/483 (47%), Gaps = 44/483 (9%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQL----LAQDMDND---PLVFGVSGEEASRFFAVE 81
P FT + ++ E++P G+ +T L LA D D D + + + G + S F +
Sbjct: 1957 PLFTKSTYQAEVM--ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDIN 2013
Query: 82 PDTGVVWLRQP--LDRETKSEFTVEFSV-SDHQGVI--TRKVNIQVGDVNDNAPTFHNQP 136
TGVV +R +DRE S +E + ++ G++ T + I + D NDN PTF
Sbjct: 2014 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2073
Query: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTV-IRELD 194
+V + EN P G + V ATD D G G ++Y + +Q F I G++ V +D
Sbjct: 2074 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATID 2133
Query: 195 YETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTT 254
E ++Y+LTV ATD+ T PLS A + I+I D+ D P F+N + ++ E + PGT
Sbjct: 2134 REEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTV 2192
Query: 255 VRIITAIDQDKGRPRGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDREN 303
+ ITAID D P+ + Y IV N FA++ +G + + ++RE
Sbjct: 2193 IANITAIDHDL-NPK-LEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNREL 2250
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS---SEYSVAITEL 360
+ + +R+ S T N+L D+NDN P+F + Y I E
Sbjct: 2251 VATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL--DVNDNTPQFKPFGITYYMERILEG 2308
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
A G L I V D + GLN + L+ ++ S GK V D
Sbjct: 2309 ATPGTTL---IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV----D 2361
Query: 421 YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
YE V +F + A+++ P V + +++ NDN PIF QP Y +++E+V VGT +
Sbjct: 2362 YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTII 2421
Query: 480 LTV 482
LTV
Sbjct: 2422 LTV 2424
Score = 151 bits (381), Expect = 2e-36
Identities = 135/475 (28%), Positives = 216/475 (45%), Gaps = 36/475 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
P F ++ L DT + +S+ + A D+D P + + + F ++ G
Sbjct: 1632 PMFQQPHYEVLLDEGPDT-LNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMG 1690
Query: 86 VVWLRQPLDRE-TKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTF---HNQ 135
V+ + LD E + +T+ + +D H+ T V + V D+NDN PTF +
Sbjct: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750
Query: 136 PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGIVTVIR-- 191
P+ V E P G ++ A D D G G V YS P F I G++ V +
Sbjct: 1751 PFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
Query: 192 ELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP 251
ELD ET Y LT+ A D+ PLS+ + I + D+ D DP+ +NLP + I E+SP
Sbjct: 1808 ELDRETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPV 1866
Query: 252 GTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI 311
+ V + A D D G + + I +GN F ++ +G++T+N LDRE + +
Sbjct: 1867 SSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER-IPEYKLT 1925
Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF- 370
++VK N D + F + D NDN P F S Y + E + G L +
Sbjct: 1926 ISVKDNPENPRIARRDYDLLLIF---LSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
Query: 371 --IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428
I +D D++ + ++ L+G S F I+ ++ + +R + +D E
Sbjct: 1983 GPILALDADQD--IYAVVTYQLLGAQSGLFDINSST----GVVTVRSGVIIDREAFSPPI 2036
Query: 429 FD-LFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ L E + A + IT++++NDNRP FS + L EN G SVL V
Sbjct: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
Score = 149 bits (375), Expect = 8e-36
Identities = 150/498 (30%), Positives = 217/498 (43%), Gaps = 48/498 (9%)
Query: 10 HVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGV 69
HV + V I+ NR P F+ ++ L E+ VG+SV +LA D ND FG
Sbjct: 440 HVGYAKVKITLINENDNR-PIFSQPLYNISLY--ENVTVGTSVLTVLATD--NDAGTFG- 493
Query: 70 SGEEASRFFAVEPD-------TGVVWLRQPLDRETKSEFTVEFSVSDHQGV-ITRKVNIQ 121
E S FF+ +PD TG++ L LD E FT+ D G T +V I
Sbjct: 494 ---EVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF---- 177
V DVNDN PTF Y + EN P T + + ATD D + YS S F
Sbjct: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
Query: 178 -FAIDSARGIVTVIRELDYE--TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP 234
++ G+++V R LDYE + LTV A D PL++ + I + D D P
Sbjct: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPP 669
Query: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294
F Y ++ E+ G TV + A D D+ R G I S ++ F ++ SG +T
Sbjct: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEIT 729
Query: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYS 354
LLDRE +IL V+ + + T T NI ++DINDN P + + Y
Sbjct: 730 TTSLLDRET---KSEYILIVRAVDGGVGH--NQKTGIATVNITLLDINDNHPTWKDAPYY 784
Query: 355 VAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIR 414
+ + E+ + + V D +LG N + N + + S T GK IR
Sbjct: 785 INLVEMTPPDSDVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTT---GK--IRTT 836
Query: 415 VAIPLDYETVDRYDFDLFAN--ESVPD-------HVGYAKVKITLINENDNRPIFSQPLY 465
A+ LD E D ++ +L SV D A V + L++ NDN P F +
Sbjct: 837 HAM-LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
Query: 466 NISLYENVTVGTSVLTVL 483
+ E + G S+ V+
Sbjct: 896 VAEVLEGIPAGVSIYQVV 913
Score = 143 bits (360), Expect = 4e-34
Identities = 130/403 (32%), Positives = 181/403 (44%), Gaps = 30/403 (7%)
Query: 92 PLDRETKSEFTVEF----SVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
PLD ET + + SV DH G KV I + + NDN P F Y++ + EN V
Sbjct: 418 PLDYETVDRYDFDLFANESVPDHVGYA--KVKITLINENDNRPIFSQPLYNISLYENVTV 475
Query: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
GT + V ATD D G G V Y F F++D G++ +I LDYE Q + LT+ A
Sbjct: 476 GTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA 535
Query: 208 TDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR 267
D T + I + DV D P F Y + E+ P T + + A D+D
Sbjct: 536 RDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
Query: 268 PRGIGYTIVSGNT-NSIFALDYIS--GVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
I Y+IVS + S F + GV++++ LD E S+G I LTV + +
Sbjct: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ--ISNGLIYLTVMAMDAGN-- 648
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
P ++TV T I V D NDN P F+ Y V++ E G A LF+ D D +
Sbjct: 649 PPLNSTVPVT--IEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATDLDRSREYG 705
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH--- 440
+Y + S F I+ S + I LD ET Y + A + H
Sbjct: 706 QESIIYSL-EGSTQFRINARSGE------ITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
G A V ITL++ NDN P + Y I+L E + V TV+
Sbjct: 759 TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVV 801
Score = 142 bits (357), Expect = 1e-33
Identities = 148/472 (31%), Positives = 216/472 (45%), Gaps = 41/472 (8%)
Query: 37 DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVEPDT--GVVWLR 90
D+ + I ED PVG V + A D D N +VF + SG A F V + G V++
Sbjct: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
Query: 91 QPLDRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQ-PYSVRIPENT 145
+PLDRE + ++ SD +G RK + + + D+NDN P + Y+V + EN
Sbjct: 1483 RPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARG-IVTVIRELDYETTQAYQ 202
GT + V ATD D+G + Y ++ F +D G I T D E Y
Sbjct: 1542 GGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH 1601
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT--A 260
L D+ T LS ++ + I D D P+F P+ + + P +IT A
Sbjct: 1602 LVATVEDEG-TPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQA 1659
Query: 261 IDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHG-FILTVKGTEL 319
+D D+G + Y IV+GN + F +D GV+T LD E SHG + L V T
Sbjct: 1660 LDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE---ISHGRYTLIVTAT-- 1714
Query: 320 NDDRTP---SDATVTTTFNILVIDINDNAPEF-NSSEYSVAITELAQVGFALPLFIQVVD 375
D+ P T TTT + V DINDN P F E +TE G P +
Sbjct: 1715 --DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE----GQPGPRVWTFLA 1768
Query: 376 KDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
D + G N E ++ G+ F+ISP V+G +R+R + LD ET+ Y+ + A
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISP--VEGV--LRVRKDVELDRETIAFYNLTICAR 1824
Query: 435 E-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
+ +P V I +++ NDN P+ NI++ EN V + V VL S
Sbjct: 1825 DRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
Score = 137 bits (345), Expect = 2e-32
Identities = 134/478 (28%), Positives = 216/478 (45%), Gaps = 55/478 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMD--NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
+ ED PVG+ + + A D D N L+ G+ S+F A+ P TG +++ LDRE K
Sbjct: 2411 VFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF-AINPTTGDIYVLSSLDREKKD 2469
Query: 100 EFTVEFSVSDHQGVITR-------KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
+ + D+ G + +V IQV DVND P F +S + EN P GT +
Sbjct: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
Query: 153 IVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
+ ATD D G G + YS + P + F +D G+VT R L ++ + + LTV ATD
Sbjct: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGG 2587
Query: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYST--NIYEHSPPGTTVRIITAIDQDKGRPR 269
+ PL L + + DV D P+F+ P T +I E P + V + A D+D+G
Sbjct: 2588 EP-PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 2646
Query: 270 GIGYTIV--SGNTN-SIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
+ Y+ + +GN + F +D ISG++ LDRE+ + IL +D P
Sbjct: 2647 AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV-YSLILVA-----SDLGQPV 2700
Query: 327 DATVTTTFNILVIDINDNAPEF-----NSSEYS-VAITELAQVGFALPLFIQVVDKDENL 380
+ + DI+DN P F S +Y + + E + G + VD DE
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE-- 2758
Query: 381 GLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES--- 436
G N++ ++ GN +F + P D + V LD E + F + A+ +
Sbjct: 2759 GPNAIVYYFIAAGNEEKNFHLQP-------DGCLLVLRDLDREREAIFSFIVKASSNRSW 2811
Query: 437 -----------VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
+ + +V++ L + ND P F++ Y + + VG+ ++ VL
Sbjct: 2812 TPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVL 2869
Score = 136 bits (342), Expect = 5e-32
Identities = 140/488 (28%), Positives = 217/488 (44%), Gaps = 51/488 (10%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F+ +LL E+ P G SV Q+ A D D N LV+ + RF + TG
Sbjct: 2067 PTFSPATLTVHLL--ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
Query: 86 VVWL-RQPLDRETKSEFTVEFSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRI 141
V+ + +DRE + + + +D V T V I + D+ND+ P F N +V +
Sbjct: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
Query: 142 PENTPVGTPIFIVNATDPDLGAG------GSVLYSFQP---PSQ--FFAIDSARGIVTVI 190
E+ GT I + A D DL G V P+Q FA++ G V V
Sbjct: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLSTL----ANLAIIITDVQDMDPIFINLP---YST 243
++ E Y++T++ D P ++ A L + + DV D P F Y
Sbjct: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL-DYISGVLTLNGLLDRE 302
I E + PGTT+ + A+D DKG + YT++ L D +G + N +D E
Sbjct: 2304 RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE 2363
Query: 303 NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQ 362
H TV+ + D+ +P A + + ++DINDN P F+ Y A+ E
Sbjct: 2364 EV---HWLNFTVRAS---DNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVP 2416
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
VG + + V D + G ++ E Y +G+ F I+PT+ I V LD E
Sbjct: 2417 VG---TIILTVTATDADSGNFALIE-YSLGDGESKFAINPTTGD------IYVLSSLDRE 2466
Query: 423 TVDRYDFDLFANESVPD-----HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGT 477
D Y A ++ D +V I +++ ND RP FS+P ++ S+YEN GT
Sbjct: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
Query: 478 SVLTVLVS 485
SV+T++ +
Sbjct: 2527 SVITMMAT 2534
Score = 135 bits (340), Expect = 9e-32
Identities = 134/450 (29%), Positives = 208/450 (46%), Gaps = 38/450 (8%)
Query: 31 FTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN-DPLVF---GVSGEEASRFFAVEPDTGV 86
F+N ++ +L E+ +G+ + ++ A +DN + + + + +A F ++ TGV
Sbjct: 1313 FSNASYEAAIL--ENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV 1370
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFH-NQPYSVRIP 142
+ ++ +DRE K +F V+D G T KV I V D NDN+P F +V IP
Sbjct: 1371 ITVQGLVDRE-KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIP 1429
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-----QFFAIDSARGIVTVIRELDYET 197
E+ PVG + V A DPD G+ G V++S + + + + G V V R LD E
Sbjct: 1430 EDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREE 1489
Query: 198 TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN-LPYSTNIYEHSPPGTTVR 256
Y L V A+D+ T P L + I D+ D P+ + Y+ ++ E+ GT V
Sbjct: 1490 LDHYILQVVASDRG-TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVV 1548
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISG-VLTLNGLLDRENPLYSHGFILTVK 315
+ A D+D G + Y I GN + F +D ISG + T DRE + H + TV+
Sbjct: 1549 QVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH-LVATVE 1607
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375
D+ TP+ + TT + ++D NDNAP F Y V + E + IQ +D
Sbjct: 1608 -----DEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALD 1661
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE-TVDRYDFDLFAN 434
DE G N +V N I++ + + I A LDYE + RY + A
Sbjct: 1662 LDE--GPNGTVTYAIVAGN----IVNTFRIDRHMGV-ITAAKELDYEISHGRYTLIVTAT 1714
Query: 435 ESVP--DH--VGYAKVKITLINENDNRPIF 460
+ P H V + + + NDN P F
Sbjct: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
Score = 122 bits (307), Expect = 6e-28
Identities = 130/463 (28%), Positives = 197/463 (42%), Gaps = 47/463 (10%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+SED P V L D D N L + ++G F+V VV LDRET
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETT 1063
Query: 99 SEFTVEFSVSD-------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
+ + + D H G T V + V DVNDN P F Y +PE+ P G I
Sbjct: 1064 AAYMLILEAIDNGPVGKRHTGTAT--VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
Query: 152 FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARG-IVTVIRELDYETTQAYQLTVNAT 208
+ ATD D G G V Y + F I + G ++ R LD E ++ L V A
Sbjct: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS-TNIYEHSPPGTTVRIITAIDQDKGR 267
+ D P+ + + + + D+ D P+F YS + E + GT+V ++ A D+D G
Sbjct: 1182 NHD-LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
Query: 268 PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
+ Y I+SG F +D +G++ LD E +++ V T D+ P
Sbjct: 1241 GGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYET---KTSYMMNVSAT----DQAPPF 1292
Query: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
+ I +++ D A +F+++ Y AI E +G + + +Q D + F
Sbjct: 1293 NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI-VRVQAYSIDNLNQITYRFN 1351
Query: 388 VYLVGNNSHHFIISPTSVQGKADIR-------IRVAIPLDYETVDRYDFDLFANESVPDH 440
Y TS Q KA + I V +D E D Y + A++ P
Sbjct: 1352 AY-------------TSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKV 1398
Query: 441 VGYAKVKITLINENDNRPIFSQPLYN-ISLYENVTVGTSVLTV 482
KV IT+++ENDN P F + +S+ E+ VG V TV
Sbjct: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV 1441
Score = 121 bits (304), Expect = 1e-27
Identities = 136/478 (28%), Positives = 203/478 (42%), Gaps = 50/478 (10%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-------NDPLVFGVSGEEASRFFAVE 81
P FT + L + E +G+SV + A D D N ++ G G+ F ++
Sbjct: 1206 PVFTQQQYSR-LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-----FEID 1259
Query: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS 138
TG++ LD ETK+ + + S +D + V I + + D A F N Y
Sbjct: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-----FFAIDSARGIVTVIREL 193
I EN +GT I V A D + Y F + F ID+ G++TV +
Sbjct: 1320 AAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLV 1377
Query: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPG 252
D E Y LTV A D + + + I + D D P F + +I E P G
Sbjct: 1378 DREKGDFYTLTVVADDGGPK--VDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG 1435
Query: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL----DYISGVLTLNGLLDRENPLYSH 308
V + A D D G + +++ SGN F + D I V L DRE H
Sbjct: 1436 QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPL-DREE--LDH 1492
Query: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSS-EYSVAITELAQVGFAL 367
+IL V ++ D + T ++DINDN P S Y+V++ E G A+
Sbjct: 1493 -YILQVVASDRGTPPRKKDHILQVT----ILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
Query: 368 PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
+QV D ++G+NS+ Y+ GN F + S +I R A P D E
Sbjct: 1548 ---VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRIS----GEIATRPAPP-DRERQSF 1599
Query: 427 YDF-DLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV-TVGTSVLTV 482
Y +E P V +T+++ENDN P+F QP Y + L E T+ TS++T+
Sbjct: 1600 YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITI 1657
Score = 120 bits (300), Expect = 4e-27
Identities = 110/368 (29%), Positives = 161/368 (43%), Gaps = 28/368 (7%)
Query: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF 177
V +++ D+NDN P F Y + E+ PVGT I V ATD D G + YS
Sbjct: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
Query: 178 FAIDSARGIVTVIRELDYETTQAYQLTVNATDQD---KTRPLSTLANLAIIITDVQDMDP 234
FAI+ G + V+ LD E Y LT A D + + I + DV D P
Sbjct: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
Query: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294
F +ST++YE+ P GT+V + A DQD+G + Y++ G F +D SG++T
Sbjct: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVT 2566
Query: 295 LNGLLDRENPLYSH-GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
+ PL S+ F LTV T D TT + VID+NDN P F
Sbjct: 2567 ------TQRPLQSYEKFSLTVVAT----DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
Query: 354 SVAITELAQVGFALPLF-IQVVDKDENLGLNSMFEVYLVGNNS--HHFIISPTSVQGKAD 410
+ ++ ++ + DKDE L + N FII P S
Sbjct: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG----- 2671
Query: 411 IRIRVAIPLDYETVDRYDFDLFAN---ESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
I+ A LD E+ Y L A+ + VP + +++ L + +DN P+F +P
Sbjct: 2672 -LIQTAQRLDRESQAVYSLILVASDLGQPVP-YETMQPLQVALEDIDDNEPLFVRPPKGS 2729
Query: 468 SLYENVTV 475
Y+ +TV
Sbjct: 2730 PQYQLLTV 2737
Score = 78.2 bits (191), Expect = 2e-14
Identities = 93/429 (21%), Positives = 169/429 (39%), Gaps = 66/429 (15%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFG---VSGEEASRFFAVEP 82
P F T L I E+ P+ S+V ++ A D D N + + +G FF ++P
Sbjct: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
Query: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT----RKVNIQVGDVNDNAPTFHNQPYS 138
+G++ Q LDRE+++ +++ SD + + + + + D++DN P F P
Sbjct: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
Query: 139 ------VRIPENTPVGTPIF-IVNATDPDLGAGGSVLYSFQPPSQFFAID-SARGIVTVI 190
+ +PE++P GT + + A D D G V Y ++ G + V+
Sbjct: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVL 2788
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLS------------TLANLAIIITDVQDMDPIFIN 238
R+LD E + V A+ P TL + +++ D+ D P F
Sbjct: 2789 RDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK 2848
Query: 239 LPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-----------SGNTNSIFALD 287
Y+ + + G+ + + A+D D G + Y+I+ S + +F +
Sbjct: 2849 AEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMG 2908
Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTEL---NDDR------TPSDATVTTTFNILV 338
+ G+L L +P Y F++ + +L ND D V N +
Sbjct: 2909 SMDGILRTFDLFMAYSPGY---FVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIP 2965
Query: 339 IDINDNAPEF------------NSSEYSVAITELAQVGFA-LPLFIQVVDKDENLGLNSM 385
+ EF N+ + + +V FA L I VV++D N L+
Sbjct: 2966 DRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
Query: 386 FEVYLVGNN 394
+ ++ N
Sbjct: 3026 RVIQMIDEN 3034
>gi|16933559 protocadherin LKC precursor [Homo sapiens]
Length = 1310
Score = 213 bits (542), Expect = 3e-55
Identities = 163/471 (34%), Positives = 236/471 (50%), Gaps = 31/471 (6%)
Query: 38 TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
T +++ ED PVG+ L+A+D DNDPL +G+SG A FFAV P TG V L LD ET
Sbjct: 31 TSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYET 89
Query: 98 KSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
F V SVSD + R++ + V D NDNAP F N +S I E PVG+ +F V A
Sbjct: 90 LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149
Query: 158 DPDLGAGGSVLYSFQP------PSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATD- 209
D D+G+ G V+YS + S+ A G + + L Y A YQL + A D
Sbjct: 150 DKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDL 209
Query: 210 -----QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
T S L+I + D D+DP F+ YS ++ E + GT+V + A+D D
Sbjct: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
KG + Y+I F + GV+ +NG LDRE L + + L V TE + +
Sbjct: 270 KGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNI 328
Query: 324 TPSDATVTTTFNILVIDINDNAPEF-NSSEYSVAIT-ELAQVGFA----------LPL-F 370
+A V+ + V+D+ND+ PEF N S + T E AQV F +P+
Sbjct: 329 YGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDD 388
Query: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR--IRVAIPLDYETVDRYD 428
+ +V D + G N F + L G ++ F +SP G A ++ +RV+ +DYE
Sbjct: 389 LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMA 448
Query: 429 FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
+ A +SV + A V I L + ND+RP F Q LY +++ E+ G+ V
Sbjct: 449 VQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVV 499
Score = 126 bits (316), Expect = 6e-29
Identities = 138/475 (29%), Positives = 215/475 (45%), Gaps = 37/475 (7%)
Query: 37 DTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRE 96
D ++ D GS+ T LL+ D F VS E A+ +V+ +V + +D E
Sbjct: 387 DDLTMVVYDPDKGSNGTFLLSLG-GPDAEAFSVSPERAAGSASVQV---LVRVSALVDYE 442
Query: 97 TKSEFTVEFSVSDH--QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF-I 153
++ V+ +D Q V I + D+ND+ PTF Y + +PE++ G+ +
Sbjct: 443 RQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDS 502
Query: 154 VNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 209
++ATDPD GA G + YS P + F +D G VTV LD E+ Y LT+ ATD
Sbjct: 503 IHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATD 562
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
LS+ L I + D+ D P+ S NI+ G I A D D+
Sbjct: 563 GGN---LSSSTTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPGTN 616
Query: 270 G--IGYTIVSGNTNSIFALDYISGVLTLNGLLDRE--NPLYSHGFILTVKGTELNDDRTP 325
+ + ++ G + F+LD +G+L G LDRE +P +LTV ++ +
Sbjct: 617 NSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLG 676
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ VT T V DINDN P FN S Y+ + E + L ++ D D+ N+
Sbjct: 677 TKVNVTIT----VEDINDNLPIFNQSSYNFTVKE--EDPGVLVGVVKAWDADQT-EANNR 729
Query: 386 FEVYLVGNNSHHFIISPTSV-QGKAD--IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 442
L G+ +++F+I + G A+ +R+ + LDYET + F+L + PD G
Sbjct: 730 ISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYET--QPVFNLTVSAENPDPQG 787
Query: 443 ---YAKVKITLINENDNRPIFS-QPLYNISLYENVTVGTSVLTVLVSPRFTAGPL 493
V + + + NDN P L I + EN + V V+ S T+ L
Sbjct: 788 GETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQL 842
Score = 93.2 bits (230), Expect = 5e-19
Identities = 101/359 (28%), Positives = 165/359 (45%), Gaps = 41/359 (11%)
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIV 187
AP F SV +PE+ PVG F + A D D + Y P + FFA+ G V
Sbjct: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
+ LDYET +++T++ +D + + +I+ D D P+F N +ST+I E
Sbjct: 80 KLASALDYETLYTFKVTISVSDP----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
Query: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTI-----VSGNTNSIFALDYISGVLTLNGLLDRE 302
P G+ V + A+D+D G + Y+I +G++ +F + +G + LNG L
Sbjct: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYN 194
Query: 303 NPLYSHGFILTVKGTELN---DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
N S + L +K +L + ++ +I V+D D P+F YS ++ E
Sbjct: 195 NK--SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
A G ++ L ++ VD D+ G+N +Y + ++ P AD IRV L
Sbjct: 253 DAAKGTSV-LTVEAVDGDK--GINDPV-IYSISYSTR-----PGWFDIGADGVIRVNGSL 303
Query: 420 DYETV----DRYDFDLFANESVPDHVGY-AKVKI----TLINENDNRPIFSQPLYNISL 469
D E + + + A E+ + G AKV I +++ ND++P F YN SL
Sbjct: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSL 358
Score = 53.5 bits (127), Expect = 5e-07
Identities = 72/273 (26%), Positives = 117/273 (42%), Gaps = 35/273 (12%)
Query: 223 AIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS 282
A++++ ++ P F+ S + E P G + A DQD P G +SG
Sbjct: 13 ALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDND-PLTYG---MSGPNAY 68
Query: 283 IFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI--D 340
FA+ +G + L LD E LY+ ++V SD + +LVI D
Sbjct: 69 FFAVTPKTGEVKLASALDYET-LYTFKVTISV-----------SDPYIQVQREMLVIVED 116
Query: 341 INDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV----GNNSH 396
NDNAP F ++ +S +I E VG ++ + VDKD ++ + V G++ H
Sbjct: 117 RNDNAPVFQNTAFSTSINETLPVG-SVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175
Query: 397 HFIISPTS---VQGKADIRIRVAI-PLDYETVD---RYDFDLFANESVPDHVGYAKVKIT 449
F I + G + A L+ + D Y S+P + I+
Sbjct: 176 LFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLP-----VFLSIS 230
Query: 450 LINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
++++ D P F + Y+ S+ E+ GTSVLTV
Sbjct: 231 VVDQPDLDPQFVREFYSASVAEDAAKGTSVLTV 263
Score = 50.4 bits (119), Expect = 4e-06
Identities = 41/148 (27%), Positives = 75/148 (50%), Gaps = 15/148 (10%)
Query: 337 LVIDINDN-APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
LV+ + N AP+F ++ SV + E VG A ++ D+D N + G N+
Sbjct: 14 LVVSVAANVAPKFLANMTSVILPEDLPVG-AQAFWLVAEDQD-----NDPLTYGMSGPNA 67
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455
+ F ++P + + +++A LDYET+ Y F + + S P ++ + + + ND
Sbjct: 68 YFFAVTPKTGE------VKLASALDYETL--YTFKVTISVSDPYIQVQREMLVIVEDRND 119
Query: 456 NRPIFSQPLYNISLYENVTVGTSVLTVL 483
N P+F ++ S+ E + VG+ V +VL
Sbjct: 120 NAPVFQNTAFSTSINETLPVGSVVFSVL 147
Score = 39.7 bits (91), Expect = 0.007
Identities = 36/116 (31%), Positives = 46/116 (39%), Gaps = 21/116 (18%)
Query: 120 IQVGDVNDNAPTF--HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS------- 170
I + DVNDNAP F N+ + V IPE + V A D D G G +L+S
Sbjct: 916 ITIEDVNDNAPYFLPENKTF-VIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFI 974
Query: 171 --------FQPPSQFFAIDSA---RGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
FQ F A G + + LD YQ+TV A D+ P
Sbjct: 975 SKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGP 1030
>gi|16933565 protocadherin 21 precursor [Homo sapiens]
Length = 859
Score = 212 bits (539), Expect = 8e-55
Identities = 163/499 (32%), Positives = 248/499 (49%), Gaps = 40/499 (8%)
Query: 12 AWLLVLISGCWGQVNRLPFFTNHFFDT----------YLLISEDTPVGSSVTQLLAQDMD 61
A L L+ C Q N F HFFD + EDTPVGS V L D +
Sbjct: 8 ALALGLLRLCLAQAN----FAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63
Query: 62 NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DP+ + +S + ++R F+V+P G + L + LDRE + E S+SD ++ KV I
Sbjct: 64 GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVI 123
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
V D ND AP F +PY +PE+ P G+ IF V+A D D G+GGSV Y Q FA+
Sbjct: 124 LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAV 183
Query: 181 DSARGIVTVI--RELDYETTQAYQLTVNATD-----QDKTRPLSTLANLAIIITDVQDMD 233
D G++ + LDYE ++ + +TV A D S + + + DVQDM
Sbjct: 184 DRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
Query: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVL 293
P+F+ PY +YE + PG+ V + A+D D+G+P I Y++V+GN + F ++ SG +
Sbjct: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAI 302
Query: 294 TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF----- 348
++ L + L V+ TE++ +P+ A T I ++D+N++ P F
Sbjct: 303 SIT---QSPAQLQREVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPPTFYGESG 358
Query: 349 NSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
+ + +++ E G L L I V D D+ G N+ F + LVG F + P +V
Sbjct: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQ--GANAKFNLQLVGPRG-IFRVVPQTVLN 415
Query: 408 KADIRIRV--AIPLDYETVDRYDFDLFANE-SVPDHV-GYAKVKITLINENDNRPIFSQP 463
+A + I V + +D+E F L A E + P+ A V I L++ NDN P F
Sbjct: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
Query: 464 LYNISLYENVTVGTSVLTV 482
Y + EN G+SV+ V
Sbjct: 476 YYVARIPENAPGGSSVVAV 494
Score = 97.1 bits (240), Expect = 4e-20
Identities = 124/479 (25%), Positives = 196/479 (40%), Gaps = 70/479 (14%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF-------FAVEPDTGVVWLRQ-- 91
L+ ED P GS + ++ A D D SG + F FAV+ +GV+ L+
Sbjct: 143 LVPEDIPAGSIIFKVHAVDRDTG------SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGA 196
Query: 92 PLDRETKSEFTVEFSVSDHQGVI---------TRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
LD E + D G + T V + V DV D AP F PY +
Sbjct: 197 TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAY 201
E+T G+ + V A D D G +LYS + F I+ G +++ + + Y
Sbjct: 257 EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVY 316
Query: 202 QLTVNATDQDKTRPLSTLANLAIII--TDVQDMDPIFINLP-----YSTNIYEHSPPGTT 254
+L V T+ + A + + I D+ + P F + ++ EH P G
Sbjct: 317 ELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEI 376
Query: 255 VR--IITAIDQDKGR----------PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302
+R IT D D+G PRGI + N ++ ++ + +D E
Sbjct: 377 LRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA----QVTIIVENSAAIDFE 432
Query: 303 NPLYSHGFILTVK--GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
+LT K E+N TP + T I ++D NDN P+F+S Y I E
Sbjct: 433 KSK-----VLTFKLLAVEVN---TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
A G ++ + + VD D + Y G + F+I P++ I + LD
Sbjct: 485 APGGSSV-VAVTAVDPDTGPWGEVKYSTY--GTGADLFLIHPST----GLIYTQPWASLD 537
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
E RY+F + A E + A+V ITL++ ND+ P F + + + + +GT V
Sbjct: 538 AEATARYNFYVKA-EDMEGKYSVAEVFITLLDVNDHPPQFGKSVQK----KTMVLGTPV 591
Score = 77.4 bits (189), Expect = 3e-14
Identities = 73/237 (30%), Positives = 106/237 (44%), Gaps = 21/237 (8%)
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS-FQP 173
T V IQ+ D NDN P F + Y RIPEN P G+ + V A DPD G G V YS +
Sbjct: 455 TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGT 514
Query: 174 PSQFFAIDSARGIVTV--IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD 231
+ F I + G++ LD E T Y V A D + ++A + I + DV D
Sbjct: 515 GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK---YSVAEVFITLLDVND 571
Query: 232 MDPIF-INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIFALDYI 289
P F ++ T + GT V+ I AID+D P + Y+I ++F ++
Sbjct: 572 HPPQFGKSVQKKTMVL-----GTPVK-IEAIDEDAEEPNNLVDYSITHAEPANVFDINSH 625
Query: 290 SGVLTLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343
+G + L LD + + L + D +PS +T +L IDI D
Sbjct: 626 TGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTA----LLKIDITD 678
Score = 73.9 bits (180), Expect = 3e-13
Identities = 81/366 (22%), Positives = 158/366 (43%), Gaps = 45/366 (12%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMD----NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
Y + EDT GS V +++A D D N L V+G + + F + +G + + Q
Sbjct: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA--FEINETSGAISITQSPA 309
Query: 95 RETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQP-----YSVRIPE 143
+ + + + V++ T V I++ D+N++ PTF+ + + + + E
Sbjct: 310 QLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNE 369
Query: 144 NTPVGTPI--FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGI----VTVIRE----L 193
+ P G + + D D GA P F + + VT+I E +
Sbjct: 370 HPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI 429
Query: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
D+E ++ + A + + S+ A++ I + D D P F +L Y I E++P G+
Sbjct: 430 DFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGS 489
Query: 254 TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLN--GLLDRENPLYSHGFI 311
+V +TA+D D G + Y+ G +F + +G++ LD E + +
Sbjct: 490 SVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAE---ATARYN 545
Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
VK ++ + ++ +T ++D+ND+ P+F S + + P+ I
Sbjct: 546 FYVKAEDMEGKYSVAEVFIT------LLDVNDHPPQFGKS------VQKKTMVLGTPVKI 593
Query: 372 QVVDKD 377
+ +D+D
Sbjct: 594 EAIDED 599
Score = 49.3 bits (116), Expect = 9e-06
Identities = 67/246 (27%), Positives = 100/246 (40%), Gaps = 31/246 (12%)
Query: 247 EHSPPGTTVRIITAIDQDKGRPRGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPL 305
E +P G+ V + D + G P I Y I +T S+F++D G +TL LDRE
Sbjct: 46 EDTPVGSHVYTLNGTDPE-GDP--ISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
Query: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365
I G L V ILV D ND AP F Y + E G
Sbjct: 103 EIEAIISISDGLNL----------VAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG- 151
Query: 366 ALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADI-RIRVAIPLDYETV 424
++ + VD+D G + + + N H SP +V + + R++ LDYE
Sbjct: 152 SIIFKVHAVDRDTGSGGSVTYFL----QNLH----SPFAVDRHSGVLRLQAGATLDYERS 203
Query: 425 DRYDFDLFANESV-----PDHVGYAKVKITLINEN--DNRPIFSQPLYNISLYENVTVGT 477
+ + A + D V A +T+ E+ D P+F Y +YE+ G+
Sbjct: 204 RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGS 263
Query: 478 SVLTVL 483
VL V+
Sbjct: 264 EVLKVV 269
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 211 bits (537), Expect = 1e-54
Identities = 156/458 (34%), Positives = 223/458 (48%), Gaps = 32/458 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95
+ E+ P G+ V L A D D + + + +++FF+++P TG V + LDR
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
Query: 96 ETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
ETKS + DH G+ R + I V D ND+ P F Q Y + EN VG +
Sbjct: 250 ETKSTHVFRVTAQDH-GMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEV 308
Query: 152 FIVNATDPDLGAGGSVLY-----SFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
V ATD D ++LY S PS+ F ID G++ +D E ++YQLTV
Sbjct: 309 LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
Query: 207 ATDQDK-TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A+DQ + P ST A + + + D D P F Y + E PG V +TA D+DK
Sbjct: 369 ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
G + Y+I+SGN F LD +G L + LD E + + L V+ D P
Sbjct: 429 GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET---TKEYTLRVRA---QDGGRP 482
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ V+ + V+DINDNAP F S+ + + E +G+ L L +Q +D D G N+
Sbjct: 483 PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY-LVLHVQAIDAD--AGDNAR 539
Query: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYA 444
E L G H F + + G I VA LD E VD Y F + A + P A
Sbjct: 540 LEYRLAG-VGHDFPFTINNGTG----WISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
V +T+++ NDN P F+QP Y + L E+ VGTSV+TV
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTV 632
Score = 183 bits (465), Expect = 3e-46
Identities = 139/459 (30%), Positives = 225/459 (49%), Gaps = 40/459 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP-------LVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
+ E+ VG V + A D D P L+ G SG S F ++P +GV+ R P+D
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEG-SGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 95 RETKSEFTVEFSVSDHQG------VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
RE + + SD QG T V + V D NDNAP F + Y V++ E+ G
Sbjct: 357 REEVESYQLTVEASD-QGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 149 TPIFIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQAYQLTV 205
P+ V A+D D G+ V YS + QF+ +D+ G + V+ LDYETT+ Y L V
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTGALDVVSPLDYETTKEYTLRV 474
Query: 206 NATDQDKTRPLSTLANLAII-ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
A D + PLS ++ L + + D+ D PIF++ P+ + E P G V + AID D
Sbjct: 475 RAQDGGRP-PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDR 323
G + Y + + F ++ +G +++ LDRE YS G E D
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSF-------GVEARDHG 586
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
TP+ T + + ++ V+D+NDN P F EY+V + E A VG ++ + + VD+D + +
Sbjct: 587 TPA-LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSV-VTVSAVDRDAHSVIT 644
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 443
GN + F I+ S G + +A+PLDY+ +Y + A++
Sbjct: 645 YQI---TSGNTRNRFSITSQSGGG----LVSLALPLDYKLERQYVLAVTASDGTRQDT-- 695
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
A++ + + + N +RP+F Y +++ E+ GT+V+ +
Sbjct: 696 AQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLI 734
Score = 175 bits (443), Expect = 1e-43
Identities = 127/424 (29%), Positives = 203/424 (47%), Gaps = 26/424 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRF-FAVEPDTGVVWLRQPLDRETK 98
++ED VG+SV + A D D ++ SG +RF + G+V L PLD + +
Sbjct: 619 LNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678
Query: 99 SEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATD 158
++ + + SD T ++ + V D N + P F + Y+V + E+ P GT + +++ATD
Sbjct: 679 RQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 159 PDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
D G + Y + F ID+ G VT ELDYE +Y L + A D + T
Sbjct: 739 EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
L I++ DV D P F+ Y ++YE PP T+V I+A D+D G + YT G
Sbjct: 799 -TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGG 857
Query: 279 NT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE--LNDDRTPSDATVTTTFN 335
+ + F ++ SG++ LDREN ++L + + RTP + TVT
Sbjct: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQ---YVLRAYAVDKGMPPARTPMEVTVT---- 910
Query: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
V+D+NDN P F E+ V + E + +G A+ + D DE M+++ + GN
Sbjct: 911 --VLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR-VTATDPDEGTNAQIMYQI-VEGNIP 966
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455
F + S + + + LDYE DR ++ L + V A V + L++ ND
Sbjct: 967 EVFQLDIFSGE------LTALVDLDYE--DRPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
Query: 456 NRPI 459
N P+
Sbjct: 1019 NPPV 1022
Score = 154 bits (389), Expect = 2e-37
Identities = 135/468 (28%), Positives = 211/468 (45%), Gaps = 41/468 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F + F +L E P+G V + A D D N L + ++G F + TG
Sbjct: 503 PIFVSTPFQATVL--ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTG 560
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
+ + LDRE ++ DH + V++ V DVNDN PTF Y+VR+
Sbjct: 561 WISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLN 620
Query: 143 ENTPVGTPIFIVNATDPDLGA-------GGSVLYSFQPPSQFFAIDSARGIVTVIRELDY 195
E+ VGT + V+A D D + G+ F SQ S G+V++ LDY
Sbjct: 621 EDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQ-----SGGGLVSLALPLDY 675
Query: 196 ETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
+ + Y L V A+D + A + + +TD P+F + Y+ N+ E P GTTV
Sbjct: 676 KLERQYVLAVTASDGTR----QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTV 731
Query: 256 RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
+I+A D+D G I Y + F +D +G +T LD E+ + S+ +T +
Sbjct: 732 VLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQV-SYTLAITAR 788
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375
D+ P + TT ILV D+NDNAP+F Y ++ E F L I D
Sbjct: 789 -----DNGIPQKSD-TTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP-FTSVLQISATD 841
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-N 434
+D L + + FI+ TS +R LD E V +Y +A +
Sbjct: 842 RDSGLNGRVFYTFQGGDDGDGDFIVESTSGI------VRTLRRLDRENVAQYVLRAYAVD 895
Query: 435 ESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ +P +V +T+++ NDN P+F Q +++ + EN +G +V V
Sbjct: 896 KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Score = 153 bits (386), Expect = 4e-37
Identities = 114/367 (31%), Positives = 169/367 (46%), Gaps = 26/367 (7%)
Query: 127 DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP-----PSQFFAID 181
+ AP F Y +PEN P GTP+ + A DPD G G + Y+ +QFF++D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 182 SARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPY 241
G VT ELD ET + V A D R S LA L I++TD D DP+F Y
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPR-RSALATLTILVTDTNDHDPVFEQQEY 294
Query: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS---IFALDYISGVLTLNGL 298
++ E+ G V + A D D I Y ++ G+ S +F +D SGV+ G
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 299 LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAIT 358
+DRE + LTV+ ++ R P + T + V D NDNAP+F+ Y V +
Sbjct: 355 VDREE---VESYQLTVEASD--QGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 359 ELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAI 417
E G + ++V D + G N++ ++ GN F + + G D V
Sbjct: 410 EDVTPGAPV---LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALD----VVS 460
Query: 418 PLDYETVDRYDFDLFANESVPDHVGYAK--VKITLINENDNRPIFSQPLYNISLYENVTV 475
PLDYET Y + A + + V + +++ NDN PIF + ++ E+V +
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
Query: 476 GTSVLTV 482
G VL V
Sbjct: 521 GYLVLHV 527
Score = 153 bits (386), Expect = 4e-37
Identities = 131/461 (28%), Positives = 206/461 (44%), Gaps = 41/461 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ ED G+ V ++ A D D N + + + A F ++ TG + + PLD ET
Sbjct: 408 VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETT 467
Query: 99 SEFTVEFSVSDHQ----GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
E+T+ D ++ V +QV D+NDNAP F + P+ + E+ P+G + V
Sbjct: 468 KEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHV 527
Query: 155 NATDPDLGAGGSVLYSFQPPSQFF--AIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
A D D G + Y F I++ G ++V ELD E Y V A D
Sbjct: 528 QAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG- 586
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
T L+ A++++ + DV D +P F Y+ + E + GT+V ++A+D+D I
Sbjct: 587 TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV--IT 644
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPL---YSHGFILTVKGTELNDDRTPSDAT 329
Y I SGNT + F++ SG GL+ PL ++L V T SD T
Sbjct: 645 YQITSGNTRNRFSITSQSG----GGLVSLALPLDYKLERQYVLAV---------TASDGT 691
Query: 330 VTTTFNILV--IDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
T I+V D N + P F SS Y+V + E G + L + DE+ G N+
Sbjct: 692 RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL---ISATDEDTGENARIT 748
Query: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKV 446
++ + I + T + LDYE Y + A ++ +P +
Sbjct: 749 YFMEDSIPQFRIDADTGA-------VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
+I + + NDN P F + Y S+YE+V TSVL + + R
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDR 842
Score = 109 bits (273), Expect = 5e-24
Identities = 91/322 (28%), Positives = 144/322 (44%), Gaps = 22/322 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN--DPLVFGV--SGEEASRFFAVEPDTGVVWLRQPLDRET 97
+ ED P +SV Q+ A D D+ + VF G++ F VE +G+V + LDRE
Sbjct: 824 VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDREN 883
Query: 98 KSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+++ + D R +V + V DVNDN P F + V + EN+P+G + V
Sbjct: 884 VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Query: 155 NATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
ATDPD G ++Y + + F +D G +T + +LDYE Y L + AT
Sbjct: 944 TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---- 999
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIY----EHSPPGTTVRIITAIDQDKGRP 268
+ PL + A + + + D D P+ N N Y S PG + + A D D
Sbjct: 1000 SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISD- 1058
Query: 269 RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
+ Y+ GN S+ L+ +G L L+ LD PL + +L G +
Sbjct: 1059 -SLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRV 1117
Query: 329 TVTT---TFNILVIDINDNAPE 347
T+ T + + + + D +PE
Sbjct: 1118 TIITDEMLTHSITLRLEDMSPE 1139
Score = 97.1 bits (240), Expect = 4e-20
Identities = 80/262 (30%), Positives = 121/262 (46%), Gaps = 22/262 (8%)
Query: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYIS 290
P F Y + E+ P GT V + AID D+G + YT + +N F+LD ++
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 291 GVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
G +T LDRE +H F +T + D + T ILV D ND+ P F
Sbjct: 239 GAVTTAEELDRETKS-THVFRVTAQ------DHGMPRRSALATLTILVTDTNDHDPVFEQ 291
Query: 351 SEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVY--LVGNNSHHFIISPTSVQGK 408
EY ++ E +VG+ + L ++ D D N ++ + G+ S F I P S
Sbjct: 292 QEYKESLRENLEVGYEV-LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV-- 348
Query: 409 ADIRIRVAIPLDYETVDRYDFDLFANESVPD---HVGYAKVKITLINENDNRPIFSQPLY 465
IR P+D E V+ Y + A++ D A V +++ ++NDN P FS+ Y
Sbjct: 349 ----IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRY 404
Query: 466 NISLYENVTVGTSVLTVLVSPR 487
+ + E+VT G VL V S R
Sbjct: 405 VVQVREDVTPGAPVLRVTASDR 426
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 208 bits (529), Expect = 1e-53
Identities = 158/469 (33%), Positives = 239/469 (50%), Gaps = 33/469 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F+ + + T L+ E+ PVGS+V D D N L + ++ ++ F V+ + G
Sbjct: 1942 PIFSLNSYSTSLM--ENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-G 1998
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQPYSV 139
V+ + + LDRE++S + + V D + T +V+I + DVNDN PTF + P
Sbjct: 1999 VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLT 2057
Query: 140 RIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETT 198
IPENTP+ T +F ATDPD G + Y+ P F+I + G V + ELD E
Sbjct: 2058 YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEV 2117
Query: 199 QAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
Y LTV ATD+ + LS+ + +++ D+ D +PIF Y I E++ GT + +
Sbjct: 2118 SNYTLTVVATDKGQPS-LSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQV 2176
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
A D D+G + Y IV+GNTN F +D ++G +T+ LDRE H LTV+ T
Sbjct: 2177 FAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYH---LTVQAT- 2232
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
DR + T T+T +I+++DIND P F S YSV + E +G +QVV +D+
Sbjct: 2233 ---DRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPE--NLGTLPRTILQVVARDD 2287
Query: 379 NLGLNSMFEVYLVGNNSHH-FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES- 436
+ G NS L G N + F +S + G V LD ET +R+ + A +S
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTLSASGELG-------VTQSLDRETKERFVLMITATDSG 2340
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
P G + + + + NDN P F+ Y ++ E+ GT VL V S
Sbjct: 2341 SPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNAS 2389
Score = 182 bits (461), Expect = 9e-46
Identities = 146/464 (31%), Positives = 217/464 (46%), Gaps = 29/464 (6%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGV 86
P F D L + E+ GS + QL A D D + LV A F ++P++G
Sbjct: 1738 PVFPTDMLD--LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGD 1795
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
+ + LDRE +S++++ D ++NI V DVND+ P F YS IPE+T
Sbjct: 1796 LIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTI 1855
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLT 204
G+ + + ATD D G G + Y + F ++ G+ + R LDYE Q Y LT
Sbjct: 1856 PGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILT 1915
Query: 205 VNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
V A D T + I DV D PIF YST++ E+ P G+TV + D D
Sbjct: 1916 VRAEDGGGQ---FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD 1972
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
G + Y+I SG++ F +D +GVL + LDRE+ + + L V+ +L
Sbjct: 1973 DGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSF---YNLVVQVHDL-PQIP 2027
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSE--YSVAITELAQVGFALPLFIQVVDKDENLGL 382
S T T +I+++D+NDN P F S + Y T + V F Q D D G
Sbjct: 2028 ASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFK----AQATDPDS--GP 2081
Query: 383 NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHV 441
NS E L+ + F I G D +R+ LD E V Y + A ++ P
Sbjct: 2082 NSYIEYTLLNPLGNKFSI------GTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLS 2135
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
+V + +++ NDN PIF+Q LY + + EN GT ++ V +
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAA 2179
Score = 171 bits (433), Expect = 2e-42
Identities = 143/457 (31%), Positives = 211/457 (46%), Gaps = 35/457 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+SE PV S ++ A D D N + + ++ F + PD G ++++ LDRE +
Sbjct: 1005 LSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQ 1063
Query: 99 SEFTVEFSVSDHQ-GVITRKVNIQV--GDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
+ + SD ++ VN+ V DVNDN P F++ Y+ E G+ + V+
Sbjct: 1064 DRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVS 1123
Query: 156 ATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYET------TQAYQLTVNATD 209
A D D G G V YSF+ F + + G +T + D E+ T + TV ATD
Sbjct: 1124 AVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATD 1183
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
Q +PL A + + + D+ D P F+ Y I E + T V ++A D D+G
Sbjct: 1184 QGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNG 1243
Query: 270 GIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE-NPLYSHGFILTVKGT-ELNDDRTPSD 327
I Y+I+ GN FA+D SG +TL G LD E P YS GT LN
Sbjct: 1244 LIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNS------ 1297
Query: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
T T NI ++D NDN P F S V + E ++G L V D + G N+
Sbjct: 1298 ---TCTLNIDILDENDNTPSFPKSTLFVDVLENMRIG---ELVSSVTATDSDSGDNADLY 1351
Query: 388 VYLVGNNSH-HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAK 445
+ G N+H F ISP + I +A LD+ET Y ++ A ++ P
Sbjct: 1352 YSITGTNNHGTFSISPNTGS------IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMS 1405
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
V I + + NDN P F S+ EN+ +GTSV++V
Sbjct: 1406 VVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442
Score = 165 bits (418), Expect = 8e-41
Identities = 134/456 (29%), Positives = 217/456 (47%), Gaps = 34/456 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRET 97
+ E+ P G+ + L A D D N + F + E R F ++P +G + LDRE
Sbjct: 592 VVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREE 651
Query: 98 KSEFTVEFSVSD----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153
++ +++ +D Q + R +N+ + D+NDN+P F+ Y I EN P G+ I
Sbjct: 652 QAFYSLLVLATDLGSPPQSSMAR-INVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT 710
Query: 154 VNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
V+ATDPDLG G+V YS + F +++ G+++ LD E AYQL + ATD
Sbjct: 711 VSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGN 770
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
+ A + I + D QD P+F + YS ++E+ G V ++A D I
Sbjct: 771 LQS-PNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNIS 827
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y I +G+ +FA++ ++G LT ++DRE + ++ GT D T
Sbjct: 828 YLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGD----------T 877
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
NI V D+NDN+P F + SV + E Q G ++ + VD DE G+N M L
Sbjct: 878 MVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSI-FQAKAVDPDE--GVNGMVLYSLKQ 934
Query: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLI 451
N + F I+ + + I + PLD Y ++ A++ VP + + +
Sbjct: 935 NPKNLFAIN------EKNGTISLLGPLDVH-AGSYQIEILASDMGVPQLSSSVILTVYVH 987
Query: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
+ NDN P+F Q Y ++L E+ V + V S +
Sbjct: 988 DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDK 1023
Score = 162 bits (411), Expect = 5e-40
Identities = 137/459 (29%), Positives = 218/459 (47%), Gaps = 44/459 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
I E +GS V + A+D D N + + +S FA+ TG++ L + LD E
Sbjct: 3098 IPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELC 3157
Query: 99 SEFTVEFSVSDHQGVITR----KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+ + S D G + R V + V DVNDN+P F + Y + EN P GT + +
Sbjct: 3158 QKHEMTISAIDG-GWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216
Query: 155 NATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIVTVIRELDYETTQAYQLTV---NATDQ 210
NATD D G + Y+ Q S F ID G++T LD+ET Q+Y LTV N D+
Sbjct: 3217 NATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3276
Query: 211 DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
++ + A + I + + P F++ Y I E +P GT V + A D+D G
Sbjct: 3277 ER----CSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGE 3332
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFIL-----TVKGTELNDDRTP 325
+ Y I + F ++ +G + ++G+LDRE +L +++G ++++
Sbjct: 3333 VHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDE---- 3388
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
T N+ V+D ND P F + YSV I+E +G + F+ D D ++ S
Sbjct: 3389 ------VTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHV-TFVSAFDSD-SIPSWSR 3439
Query: 386 FEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGY 443
F ++ GN + F I+P + Q I V LD ET+ Y+ + A +S P G
Sbjct: 3440 FSYFIGSGNENGAFSINPQTGQ------ITVTAELDRETLPIYNLSVLAVDSGTPSATGS 3493
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
A + +TL + NDN P+ + + + EN GT V+T+
Sbjct: 3494 ASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTL 3530
Score = 160 bits (406), Expect = 2e-39
Identities = 126/449 (28%), Positives = 213/449 (47%), Gaps = 25/449 (5%)
Query: 42 ISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
+ E++P+G +VT++ D D + S +AS F + P TG + + +PL+RE
Sbjct: 2781 VPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNREDTDR 2840
Query: 101 FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPD 160
+ + S D ++ V I V D+NDNAP F Y + PE T +G+ + V ATDPD
Sbjct: 2841 YRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPD 2900
Query: 161 LGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAY-QLTVN-----ATDQDKTR 214
G+ G V Y + S++F I++ G + + L Y+ + + +N T D+ +
Sbjct: 2901 EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK 2960
Query: 215 P-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI-DQDKGRPRGIG 272
P L + + I I D D P F+ Y T + ++ GT + +TAI D+D G +
Sbjct: 2961 PSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVE 3020
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y I + N F LD +G +++ L + + F +TV + + S ATV
Sbjct: 3021 YFISNDNHLGKFKLDNDTGWISVASSLISD---LNQNFFITVTAKDKGNPPLSSQATV-- 3075
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
+I V + N + PEF+ S S I E +G + V +D + +N + + Y +
Sbjct: 3076 --HITVTEENYHTPEFSQSHMSATIPESHSIG---SIVRTVSARDRDAAMNGLIK-YSIS 3129
Query: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVKITLI 451
+ + I + S G + +A LDYE +++ + A + GY V + +I
Sbjct: 3130 SGNEEGIFAINSSTG----ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI 3185
Query: 452 NENDNRPIFSQPLYNISLYENVTVGTSVL 480
+ NDN P+F Y ++ EN GT+V+
Sbjct: 3186 DVNDNSPVFLSDDYFPTVLENAPSGTTVI 3214
Score = 160 bits (404), Expect = 4e-39
Identities = 131/452 (28%), Positives = 214/452 (47%), Gaps = 37/452 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQP--LDRE 96
+SE+ P GS V+ + A D D N L + + +F + +G+V LDRE
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 97 TKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP--YSVRIPENTPVGTPI 151
S+ + S D H V ++ + + DVND P F +QP Y V + EN P GT +
Sbjct: 544 LASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVF-SQPEGYDVSVVENAPTGTEL 602
Query: 152 FIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
++ ATD DLG G+V +S Q + F +D G ++ I LD E Y L V AT
Sbjct: 603 LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLAT 662
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
D + P S++A + + + D+ D P+F + Y +I E+ P G+ + ++A D D G
Sbjct: 663 DLG-SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 269 RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
+ Y+I +G+ S F ++ SGV++ LDRE + L + T+ + ++P+ A
Sbjct: 722 GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREE---KTAYQLQIVATDGGNLQSPNQA 777
Query: 329 TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFE 387
VT T V+D DN P F+ YS + E +G+ + + +D + N+
Sbjct: 778 IVTIT----VLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNIS------ 827
Query: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
YL+ + + V G ++ A +D E Y + A+ G V
Sbjct: 828 -YLITTGDQKGMFAINQVTG----QLTTANVIDREEQSFYQLKVVASGGTV--TGDTMVN 880
Query: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
IT+ + NDN P F Q + ++++ EN G S+
Sbjct: 881 ITVKDLNDNSPHFLQAIESVNVVENWQAGHSI 912
Score = 155 bits (391), Expect = 1e-37
Identities = 138/470 (29%), Positives = 218/470 (46%), Gaps = 46/470 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ ED VGSSV Q+ A D D N + + + E F ++P+TG++ +R+PLD E +
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEAR 316
Query: 99 SEFTVEFSVSDHQGV--ITRKVN--IQVGDVNDNAPT--FHNQPYSVR---IPENTPVGT 149
++++ D +GV +T + IQ+ DVNDN P F P + R + EN VGT
Sbjct: 317 RQYSLTVQAMD-RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGT 375
Query: 150 PIFIVNATDPDLGAGG---SVLYSFQPPSQFFAIDSAR----GIVTVIRELDYETTQAYQ 202
+ ++ TD D A SV + F + S++ ++ V LD E +Y
Sbjct: 376 VVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYN 435
Query: 203 LTVNATDQDKTRP------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
LTV+ +D P S++A+L I + D+ D P+F Y N+ E +PPG+ V
Sbjct: 436 LTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVS 495
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL--NGLLDRENPLYSHGFILTV 314
I+A D D G + Y+IVSGN F + SG++T +G LDRE + +L +
Sbjct: 496 GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE---LASQIVLNI 552
Query: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQV 373
+ S A + T ++D+ND P F+ E Y V++ E A G L L ++
Sbjct: 553 SARDQGVHPKVSYAQLVVT----LLDVNDEKPVFSQPEGYDVSVVENAPTGTEL-LMLRA 607
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
D D F + + F + P S R+ LD E Y + A
Sbjct: 608 TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG------RLSTISSLDREEQAFYSLLVLA 661
Query: 434 NE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ P A++ ++L++ NDN P+F Y + EN G+ + TV
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTV 711
Score = 151 bits (381), Expect = 2e-36
Identities = 131/457 (28%), Positives = 205/457 (44%), Gaps = 34/457 (7%)
Query: 41 LISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
++ E+ +G V + A MD N + + ++ + FA+ TG + +DRE +S
Sbjct: 801 VVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQS 860
Query: 100 EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
+ ++ S VNI V D+NDN+P F SV + EN G IF A DP
Sbjct: 861 FYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDP 920
Query: 160 DLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
D G G VLYS Q P FAI+ G ++++ LD +YQ+ + A+D + LS+
Sbjct: 921 DEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVH-AGSYQIEILASDMGVPQ-LSS 978
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
L + + DV D P+F L Y + E P + + A D+D G I YTI G
Sbjct: 979 SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038
Query: 279 NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILV 338
NT F + + G L + LDRE ++L V + DR + T +++
Sbjct: 1039 NTGDAFGI-FPDGQLYIKSELDRE---LQDRYVLMV----VASDRAVEPLSATVNVTVIL 1090
Query: 339 IDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLNSMFEVYLVGNNSH 396
D+NDN P FNS+ Y+ E + G + + VDKD N + FE+ H
Sbjct: 1091 EDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-VSAVDKDFGPNGEVRYSFEMVQPDFELH 1149
Query: 397 HFIISPTSVQGKADIRIRVAIPLDYETVDR------YDFDLFA-NESVPDHV-GYAKVKI 448
++ G+ I D E++ R + F + A ++ +P + A V +
Sbjct: 1150 -------AISGE----ITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198
Query: 449 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
+ + NDN P F + Y ++ E+ T VL V S
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235
Score = 150 bits (378), Expect = 4e-36
Identities = 132/459 (28%), Positives = 211/459 (45%), Gaps = 42/459 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E+ +G V+ + A D D N L + ++G F++ P+TG ++L + LD ET+
Sbjct: 1324 VLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQ 1383
Query: 99 SEFTVEFSVSDHQG----VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
S + + + D QG T V I V D NDN P+F I EN P+GT + V
Sbjct: 1384 SLYKLNITAKD-QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442
Query: 155 NATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
A DPD G + Y+ P F ID +G + E+D E ++LTV A DQ
Sbjct: 1443 TAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQ- 1501
Query: 212 KTRPLST----LANLAIIITDVQDMDPIFINLPYSTNIYEHSPP---GTTVRIITAIDQD 264
P+ T L N+ I++TD+ D P+FI S N P G+ + I A D D
Sbjct: 1502 -AVPIETRRYALKNVTILVTDLNDNVPMFI----SQNALAADPSAVIGSVLTTIMAADPD 1556
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
+G I Y I++G+T++ F +D SG L + L +Y+ L V T+L +R
Sbjct: 1557 EGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALVPSQLIYN----LIVSATDLGPERR 1611
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
S TT I++ + + P F +Y + E +G + ++ G +
Sbjct: 1612 KS----TTELTIILQGL--DGPVFTQPKYITILKEGEPIG----TNVISIEAASPRGSEA 1661
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE--SVPDHV 441
E Y+V + G+ I+ A LD E Y D++A E +
Sbjct: 1662 PVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRT 1721
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
A+V+ITL + NDN P+F + ++++ EN+ G+ ++
Sbjct: 1722 QRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIM 1760
Score = 150 bits (378), Expect = 4e-36
Identities = 129/466 (27%), Positives = 215/466 (46%), Gaps = 27/466 (5%)
Query: 25 VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDT 84
VN+ F + + E+ PV S VT + + +P+ + ++ F ++ T
Sbjct: 2559 VNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLT 2618
Query: 85 GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRI 141
G V + QPLD E ++ V D K++I V DVNDNAP F P+ I
Sbjct: 2619 GQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEI 2678
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
EN I V+A D D G G + Y + F+I+ A G + +R LD E
Sbjct: 2679 LENLS-PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVS 2737
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y LT+ ++D+ ST + I I D D P F + +S ++ E+SP G TV +T
Sbjct: 2738 HYVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVT 2795
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D+D G Y+I+ + F ++ +G + ++ L+RE+ + + + V +
Sbjct: 2796 TSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNRED---TDRYRIRVSAHD- 2849
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
S TV+T I V DINDNAP F+ + Y + EL ++G + QV D +
Sbjct: 2850 ------SGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKV---TQVFATDPD 2900
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
G N Y + + S +F I+ T+ + K ++ + ++R+ F + +++
Sbjct: 2901 EGSNGQV-FYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG 2959
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
P + V I +++ NDN P F + Y + +NV VGT ++ V
Sbjct: 2960 KPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRV 3005
Score = 149 bits (376), Expect = 6e-36
Identities = 138/478 (28%), Positives = 223/478 (46%), Gaps = 35/478 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F F+ ISE + V ++ A D+D N + + + R FA++ +G
Sbjct: 1208 PKFLKDFYQA--TISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSG 1265
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPTFHNQPYSVRI 141
V L LD E +++ D G I T +NI + D NDN P+F V +
Sbjct: 1266 QVTLIGKLDYEATPAYSLVIQAVD-SGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDV 1324
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQ 199
EN +G + V ATD D G + YS + F+I G + + ++LD+ET
Sbjct: 1325 LENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQS 1384
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y+L + A DQ + P S+ ++ I + D D P F +I E+ P GT+V +T
Sbjct: 1385 LYKLNITAKDQGRP-PRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVT 1443
Query: 260 AIDQDKGRPRGIGYTIVSGNTN-SIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
A D D + YTI+ + F +D + G + N +DRE +++ F LTVK
Sbjct: 1444 AHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDRE---FANLFELTVKA-- 1498
Query: 319 LNDDRTPSDATVTTTFN--ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDK 376
ND P + N ILV D+NDN P F S+ ++A A +G L I D
Sbjct: 1499 -NDQAVPIETRRYALKNVTILVTDLNDNVPMF-ISQNALAADPSAVIGSVLTT-IMAADP 1555
Query: 377 DENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES 436
DE G N E ++ ++ FI+ S D+R+ A+ + + + Y+ + A +
Sbjct: 1556 DE--GANGEIEYEIINGDTDTFIVDRYS----GDLRVASAL-VPSQLI--YNLIVSATDL 1606
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV-LVSPRFTAGPL 493
P+ + ++T+I + + P+F+QP Y L E +GT+V+++ SPR + P+
Sbjct: 1607 GPER-RKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPV 1663
Score = 146 bits (369), Expect = 4e-35
Identities = 137/461 (29%), Positives = 204/461 (44%), Gaps = 53/461 (11%)
Query: 69 VSGEEASRF---FAVEPDTGVVWL----RQPLDRETKSEFTVEFSVSDHQGVITR---KV 118
+ G EA RF + P +L + LDRE ++ + V D R +V
Sbjct: 177 IRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQV 236
Query: 119 NIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFF 178
N+ V D+NDN P F + Y +PE+ VG+ + V A D D G + Y Q F
Sbjct: 237 NVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPF 296
Query: 179 AIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI--F 236
+D G++TV LD+E + Y LTV A D+ L+ A I + DV D DP+ F
Sbjct: 297 QMDPETGLITVREPLDFEARRQYSLTVQAMDRG-VPSLTGRAEALIQLLDVNDNDPVVKF 355
Query: 237 INLPYST---NIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIFALDYIS-- 290
P ++ ++ E++ GT V ++T D D G I I+ GN F +
Sbjct: 356 RYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVP 415
Query: 291 --GVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDA----TVTTTFNILVIDIND 343
++ + LDRE P Y+ LTV ++ N P A + + I V DIND
Sbjct: 416 NLSLIKVASALDRERIPSYN----LTVSVSD-NYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 344 NAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN------SHH 397
+ P F+ Y V ++E A G + I D D L N + + + GN S H
Sbjct: 471 HPPVFSQQVYRVNLSEEAPPG-SYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISEH 528
Query: 398 FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
+ T G D + I L+ D + V V YA++ +TL++ ND +
Sbjct: 529 SGLVTTGSSGGLDRELASQIVLNISARD---------QGVHPKVSYAQLVVTLLDVNDEK 579
Query: 458 PIFSQPL-YNISLYENVTVGTSVLTVLVSPRFTAGPLSSPG 497
P+FSQP Y++S+ EN GT +L + R T G L G
Sbjct: 580 PVFSQPEGYDVSVVENAPTGTELLML----RATDGDLGDNG 616
Score = 146 bits (369), Expect = 4e-35
Identities = 132/448 (29%), Positives = 206/448 (45%), Gaps = 34/448 (7%)
Query: 57 AQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV 113
A D D+ P L + + F++ TG + +PLDRE S + + SD
Sbjct: 2692 AMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSP 2751
Query: 114 ---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS 170
+ KV I + D NDNAP F +Q +S +PEN+P+G + V +D D+G YS
Sbjct: 2752 SQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYS 2810
Query: 171 FQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQ 230
S F I+ + G + + R L+ E T Y++ V+A D T +ST ++ I +TD+
Sbjct: 2811 IMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWT--VST--DVTIFVTDIN 2866
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYIS 290
D P F Y + E + G+ V + A D D+G + Y I S + F ++ +
Sbjct: 2867 DNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKS--QSEYFRINATT 2924
Query: 291 GVLTLNGLLDREN-------PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343
G + +L +N + H FI+T + DR TT I ++D ND
Sbjct: 2925 GEIFNKQILKYQNVTGFSNVNINRHSFIVT------SSDRGKPSLISETTVTINIVDSND 2978
Query: 344 NAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT 403
NAP+F S+Y +T+ +VG L + DKD GLNS E Y + N++H
Sbjct: 2979 NAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKD--FGLNSEVE-YFISNDNHLGKFKLD 3035
Query: 404 SVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQ 462
+ G I VA L + + + A ++ P A V IT+ EN + P FSQ
Sbjct: 3036 NDTG----WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQ 3091
Query: 463 PLYNISLYENVTVGTSVLTVLVSPRFTA 490
+ ++ E+ ++G+ V TV R A
Sbjct: 3092 SHMSATIPESHSIGSIVRTVSARDRDAA 3119
Score = 142 bits (357), Expect = 1e-33
Identities = 124/439 (28%), Positives = 203/439 (46%), Gaps = 33/439 (7%)
Query: 51 SVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSV 107
++ Q++A+D D N L + + G F + +G + + Q LDRETK F + +
Sbjct: 2278 TILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITA 2336
Query: 108 SDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAG 164
+D T +N+ V DVNDN PTF ++ Y IPE+ P GT + +VNA+D D +
Sbjct: 2337 TDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDAD-ASK 2395
Query: 165 GSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAI 224
+V+ SQF I+ + G + LD ET Y L V +D PLS+ ++ +
Sbjct: 2396 NAVIRIIGGNSQF-TINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLV 2454
Query: 225 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIF 284
+TDV D P F + PY T+I + PG+ V +T D D G + Y++ SG + F
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKF 2513
Query: 285 ALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDN 344
+D + G + G L+ + + F + VK D T +TT + ++ D
Sbjct: 2514 HIDPLRGAIMAAGPLNGASEV---TFSVHVK------DGGSFPKTDSTTVTVRFVNKAD- 2563
Query: 345 APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTS 404
P+ + E + E V + +L M GN + F I +
Sbjct: 2564 FPKVRAKEQTFMFPENQPVSSLVTTI-----TGSSLRGEPMSYYIASGNLGNTFQIDQLT 2618
Query: 405 VQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQP 463
Q + ++ PLD+E + +Y + A + P Y K+ IT+++ NDN PIF +
Sbjct: 2619 GQ------VSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKED 2672
Query: 464 LYNISLYENVTVGTSVLTV 482
+ + EN++ +LTV
Sbjct: 2673 PFISEILENLS-PRKILTV 2690
Score = 141 bits (355), Expect = 2e-33
Identities = 140/484 (28%), Positives = 214/484 (44%), Gaps = 49/484 (10%)
Query: 14 LLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLA-----QDMDNDPLVFG 68
L +++ G G P FT + T ++ E P+G++V + A + + +
Sbjct: 1617 LTIILQGLDG-----PVFTQPKYIT--ILKEGEPIGTNVISIEAASPRGSEAPVEYYIVS 1669
Query: 69 VSGEEAS--RFFAVEPDTGVVWLRQPLDRETKS-EFTVEFSVSDHQGVITR----KVNIQ 121
V EE + R F + TG++ LDRE + + V+ + R +V I
Sbjct: 1670 VRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEIT 1729
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS-FQPPSQFFAI 180
+ D+NDN P F + + EN G+ I + A D D GA V Y+ F I
Sbjct: 1730 LQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRI 1789
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
D G + R LD E Y L V A D ++ + + I ++DV D P F
Sbjct: 1790 DPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDM----RINITVSDVNDHTPKFSRPV 1845
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
YS +I E + PG+ V I A D D G I Y + + + IF L+ I+GV L LLD
Sbjct: 1846 YSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLD 1905
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
E Y +ILTV+ +D T+ FNIL D+NDN P F+ + YS ++ E
Sbjct: 1906 YEVQQY---YILTVRA----EDGGGQFTTIRVYFNIL--DVNDNPPIFSLNSYSTSLMEN 1956
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPL 419
VG + +F V D D+ G+NS + G++ F + V ++V L
Sbjct: 1957 LPVGSTVLVF-NVTDADD--GINSQLTYSIASGDSLGQFTVDKNGV-------LKVLKAL 2006
Query: 420 DYETVDRYDFDLFANE--SVP--DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTV 475
D E+ Y+ + ++ +P A+V I L++ NDN P F P + EN +
Sbjct: 2007 DRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPI 2065
Query: 476 GTSV 479
T V
Sbjct: 2066 DTVV 2069
Score = 132 bits (332), Expect = 8e-31
Identities = 129/464 (27%), Positives = 203/464 (43%), Gaps = 38/464 (8%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVW 88
F + +F T I ED P G+ V + A D D + V + G + F + P TG +
Sbjct: 2364 FASKAYFTT---IPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ--FTINPSTGQII 2418
Query: 89 LRQPLDRETKSEFTVEFSVSDHQG----VITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN 144
LDRETK +T+ SD + V + V DVNDN P F + PY IP
Sbjct: 2419 TSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSP 2478
Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIVTVIRELDYETTQAYQL 203
T G+ +F V TD D+G + YS S+ F ID RG + L+ + + +
Sbjct: 2479 TLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSV 2538
Query: 204 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
V +T + + V D + T ++ + P ++ ++T I
Sbjct: 2539 HVKDGGSFPKTDSTT-----VTVRFVNKADFPKVRAKEQTFMFPENQPVSS--LVTTITG 2591
Query: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
R + Y I SGN + F +D ++G ++++ LD E +++ + E D
Sbjct: 2592 SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEK---IQKYVVWI---EARDGG 2645
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
P ++ +I V+D+NDNAP F + I E + L + +DKD G N
Sbjct: 2646 FPPFSSY-EKLDITVLDVNDNAPIFKEDPFISEILE--NLSPRKILTVSAMDKDS--GPN 2700
Query: 384 SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL-FANESVPDHV 441
+ +V GN + F I+ A IR PLD E V Y + +++ P
Sbjct: 2701 GQLDYEIVNGNMENSFSIN------HATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQS 2754
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
KV I +++ENDN P FSQ +++ + EN +G +V V S
Sbjct: 2755 TSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTS 2797
Score = 126 bits (317), Expect = 4e-29
Identities = 137/443 (30%), Positives = 200/443 (45%), Gaps = 42/443 (9%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
F ++ +F T L E+ P G++V L A D D N + + V + S F ++P+TGV
Sbjct: 3194 FLSDDYFPTVL---ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNTGV 3249
Query: 87 VWLRQPLDRETKSEF--TVE-FSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
+ + LD ETK + TV+ F+V D + VNIQ+ N+ P F ++ Y I E
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISE 3309
Query: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
P GT + V A+D DLG G V Y S+ F I+ G + V LD E +
Sbjct: 3310 AAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERV 3369
Query: 202 QLTVNATDQDKTRPLST-LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITA 260
L V A + R + + + D D PIF YS I E P GT V ++A
Sbjct: 3370 SLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSA 3428
Query: 261 IDQDKGRPRG-IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTE 318
D D Y I SGN N F+++ +G +T+ LDRE P+Y+ +
Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAV----- 3483
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD- 377
D TPS AT + + + + DINDN P SE V E + G L + +Q D D
Sbjct: 3484 --DSGTPS-ATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPG-TLVMTLQSTDPDL 3537
Query: 378 -ENLGLNSMFEVYLV--GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
N G F YL+ G + +F +S V + +D E + + +
Sbjct: 3538 PPNQG---PFTYYLLSTGPATSYFSLSTAGV-------LSTTREIDREQIADFYLSVVTK 3587
Query: 435 ES-VPDHVGYAKVKITLINENDN 456
+S VP V IT+I++NDN
Sbjct: 3588 DSGVPQMSSTGTVHITVIDQNDN 3610
Score = 123 bits (309), Expect = 4e-28
Identities = 113/432 (26%), Positives = 188/432 (43%), Gaps = 38/432 (8%)
Query: 73 EASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
E+ FA+ TG ++ +DRE+ + V +V + V D+NDNAP F
Sbjct: 76 ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVF 135
Query: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ----PPSQFFAID-----SA 183
+ V E++ G + + ATD D+G+ G S++ + F +D S
Sbjct: 136 PDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSG 195
Query: 184 RGIVTVIRE---LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
G + LD E T YQL V D+ + + L + + + D+ D P+F +
Sbjct: 196 EGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYL-QVNVTVQDINDNPPVFGSSH 254
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Y + E + G++V + A D D+G I Y + T F +D +G++T+ LD
Sbjct: 255 YQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLD 312
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP-----EFNSSEYSV 355
E + LTV+ DR T I ++D+NDN P F ++
Sbjct: 313 FE---ARRQYSLTVQAM----DRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYA 365
Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
++ E AQVG + L + V D D ++ L GN HF + + V + I+V
Sbjct: 366 SVDENAQVGTVVAL-LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLS--LIKV 422
Query: 416 AIPLDYETVDRYDFDLFANE--------SVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
A LD E + Y+ + ++ +V A + I + + ND+ P+FSQ +Y +
Sbjct: 423 ASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRV 482
Query: 468 SLYENVTVGTSV 479
+L E G+ V
Sbjct: 483 NLSEEAPPGSYV 494
Score = 106 bits (264), Expect = 6e-23
Identities = 100/366 (27%), Positives = 154/366 (42%), Gaps = 29/366 (7%)
Query: 128 NAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-------QPPSQFFAI 180
+ P F Y + E P+GT + + A P G+ V Y + + F I
Sbjct: 1625 DGPVFTQPKYITILKEGEPIGTNVISIEAASPR-GSEAPVEYYIVSVRCEEKTVGRLFTI 1683
Query: 181 DSARGIVTVIRELDYETTQA-YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINL 239
GI+ LD E Y + V A ++ P + A + I + D+ D P+F
Sbjct: 1684 GRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTD 1743
Query: 240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLL 299
+ E+ G+ + +TA+D D+G + YTI+SG +S F +D SG L L
Sbjct: 1744 MLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRL 1802
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE + G + +D R NI V D+ND+ P+F+ YS I E
Sbjct: 1803 DRERRSKYSLLVRADDGLQSSDMR----------INITVSDVNDHTPKFSRPVYSFDIPE 1852
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
G L ++ D++ G+N Y+V + I + G + L
Sbjct: 1853 DTIPG---SLVAAILATDDDSGVNGEI-TYIVNEDDEDGIFFLNPITGV----FNLTRLL 1904
Query: 420 DYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
DYE Y + A E +V +++ NDN PIFS Y+ SL EN+ VG++V
Sbjct: 1905 DYEVQQYYILTVRA-EDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTV 1963
Query: 480 LTVLVS 485
L V+
Sbjct: 1964 LVFNVT 1969
Score = 97.4 bits (241), Expect = 3e-20
Identities = 98/341 (28%), Positives = 151/341 (44%), Gaps = 27/341 (7%)
Query: 28 LPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDT 84
+P F + + Y ISE P G+ V ++ A D D + + + + G + F + T
Sbjct: 3295 VPRFVSKLY--YFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKT 3352
Query: 85 GVVWLRQPLDRETKSEFTVE-----FSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
G +++ LDRE + +++ F + VN+ V D ND P F YSV
Sbjct: 3353 GQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSV 3411
Query: 140 RIPENTPVGTPIFIVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYE 196
+I E P+GT + V+A D D S F + F+I+ G +TV ELD E
Sbjct: 3412 QISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRE 3471
Query: 197 TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
T Y L+V A D T + A+L + + D+ D P+ + E+ PGT V
Sbjct: 3472 TLPIYNLSVLAVDSG-TPSATGSASLLVTLEDINDNGPML--TVSEGEVMENKRPGTLVM 3528
Query: 257 IITAIDQDKGRPRG--IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTV 314
+ + D D +G Y + +G S F+L +GVL+ +DRE F L+V
Sbjct: 3529 TLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS-TAGVLSTTREIDREQ---IADFYLSV 3584
Query: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV 355
+ D + T T +I VID NDN + + E V
Sbjct: 3585 ----VTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFV 3621
Score = 70.9 bits (172), Expect = 3e-12
Identities = 68/251 (27%), Positives = 107/251 (42%), Gaps = 19/251 (7%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPL-----VFGVSGEEASRFFAV 80
N P FT + + ISE P+G+ VT + A D D+ P F SG E F ++
Sbjct: 3399 NDPPIFTLNIYSVQ--ISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAF-SI 3455
Query: 81 EPDTGVVWLRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPY 137
P TG + + LDRET + + D + + + + D+NDN P
Sbjct: 3456 NPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEG 3515
Query: 138 SVRIPENTPVGTPIFIVNATDPDL----GAGGSVLYSFQPPSQFFAIDSARGIVTVIREL 193
V EN GT + + +TDPDL G L S P + +F++ +A G+++ RE+
Sbjct: 3516 EVM--ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTA-GVLSTTREI 3572
Query: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
D E + L+V T +S+ + I + D D + N Y + PG
Sbjct: 3573 DREQIADFYLSV-VTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGG 3631
Query: 254 TVRIITAIDQD 264
+ + D D
Sbjct: 3632 ILGSVKPQDPD 3642
Score = 65.9 bits (159), Expect = 9e-11
Identities = 65/242 (26%), Positives = 103/242 (42%), Gaps = 24/242 (9%)
Query: 245 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP 304
+ E PPGT V I RP G+T ++++FA++ +G L +DRE
Sbjct: 51 VLEEQPPGTLVGTIQT------RP---GFTYRLSESHALFAINSSTGALYTTSTIDRE-- 99
Query: 305 LYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVG 364
++ +N S T T +LV D+NDNAP F V E + G
Sbjct: 100 --------SLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSG 151
Query: 365 FALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT---SVQGKADIRIRVAIPLDY 421
+ L + G++ + GN + F + T S +G A + + LD
Sbjct: 152 RQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEG-AFLHLVSKGGLDR 210
Query: 422 ETVDRYDFDL-FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
E +Y + ++ P GY +V +T+ + NDN P+F Y + E+ VG+SVL
Sbjct: 211 EVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL 270
Query: 481 TV 482
V
Sbjct: 271 QV 272
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 196 bits (497), Expect = 6e-50
Identities = 147/451 (32%), Positives = 228/451 (50%), Gaps = 24/451 (5%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
I ED G + Q+ A D D N + + + G A +F + PDTG + PLDRE +
Sbjct: 3032 IPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKF-KLNPDTGELKTSTPLDREEQ 3090
Query: 99 SEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
+ + + +D G + + + + DVNDNAP F PY++ + ENT GT + V AT
Sbjct: 3091 AVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQAT 3150
Query: 158 DPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPL 216
D D G +LYS + F+I+ GI+ + + LD E Y L++ A DQ R L
Sbjct: 3151 DADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRL 3210
Query: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV 276
+ + + + D+ D P+F Y + E GT V + A +D I Y+I+
Sbjct: 3211 TATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSII 3270
Query: 277 SGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNI 336
SGN + F++D +G + + LD E+ SH + LTV+ T D TPS + V T N+
Sbjct: 3271 SGNEHGKFSIDSKTGAVFIIENLDYES---SHEYYLTVEAT---DGGTPSLSDVATV-NV 3323
Query: 337 LVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNS 395
V DINDN P F+ Y+ I+E A + ++ I V+ D + NS ++ GN
Sbjct: 3324 NVTDINDNTPVFSQDTYTTVISEDAVLEQSV---ITVMADDADGPSNSHIHYSIIDGNQG 3380
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINEN 454
F I P V+G+ ++V LD ET+ Y + A+++ P V V I + + N
Sbjct: 3381 SSFTIDP--VRGE----VKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVN 3434
Query: 455 DNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
DN P+FS+ Y++ + EN VG SVL ++V+
Sbjct: 3435 DNAPVFSRGNYSVIIQENKPVGFSVLQLVVT 3465
Score = 172 bits (437), Expect = 5e-43
Identities = 136/455 (29%), Positives = 216/455 (47%), Gaps = 25/455 (5%)
Query: 38 TYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
T + + E+ PVGSSV + + D+D N LV+ VSG F ++ +TG++ + PLD
Sbjct: 722 TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLD 781
Query: 95 RETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
RET ++T+ +V D Q R +++ V D NDN P F + Y V + E+ V + I
Sbjct: 782 RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841
Query: 152 FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
V ATD DLG G V YS + F+IDS G+V + R LD E + L + A DQ
Sbjct: 842 IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA 901
Query: 212 KTRP-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
+ P L + + + + DV D P FI Y + E P GT + + A D D G+
Sbjct: 902 REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQ 961
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
+ Y+++ + F +D +SG + + LD E + LTV+ D P +
Sbjct: 962 VRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEK---KQVYNLTVRA---KDKGKPVSLSS 1014
Query: 331 TTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
T + V+D+N+N P F+S + E A VG +L + + D+D + +
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG-SLVMTVSAHDEDARRDGEIRYSI 1073
Query: 389 YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVK 447
G+ F I G+ I + LD E+ Y +FA ++ V + ++
Sbjct: 1074 -RDGSGVGVFKI------GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126
Query: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
I + + NDN P S+P+Y + EN SV+ +
Sbjct: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
Score = 171 bits (434), Expect = 1e-42
Identities = 140/473 (29%), Positives = 222/473 (46%), Gaps = 41/473 (8%)
Query: 27 RLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEE-ASRFFAVEPD 83
+LP F+ F+ +SED P+G+ + + A+ LV G + E F ++
Sbjct: 2699 QLPKFSEPFYT--FTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQ 2756
Query: 84 TGVVWLRQPLDRETKSEFTVEFSV------SDHQGVITRKVNIQVGDVNDNAPTFHNQPY 137
+G + L + LD ET + +FS+ DH+ V + V+IQV D NDN+P F + PY
Sbjct: 2757 SGRLKLEKSLDHETTKWY--QFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPY 2814
Query: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-----QFFAIDSARGIVTVIRE 192
I EN P G+ + + A+D D G G V+YS + FAI+ G +T ++E
Sbjct: 2815 EAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKE 2874
Query: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
LD+E YQ+ V A+D + LS+ A + + +TDV D P F Y + E P G
Sbjct: 2875 LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG 2934
Query: 253 TTVRIITAIDQDKGR-PRGIGYTIVSGNTNSIFALDYISG--VLTLNGLLDRENPLYSHG 309
+ I++ D D R + Y I G+ FA++ I + + LDRE
Sbjct: 2935 GVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREK---RDN 2991
Query: 310 FILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPL 369
++LT+ T D S A V + V+D NDN+P + YS I E G L
Sbjct: 2992 YLLTITAT---DGTFSSKAIV----EVKVLDANDNSPVCEKTLYSDTIPEDVLPG---KL 3041
Query: 370 FIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
+Q+ D ++ N+ L+G+ + F ++P + + ++ + PLD E Y
Sbjct: 3042 IMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE------LKTSTPLDREEQAVYHL 3095
Query: 430 DLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ A + A + +TL + NDN P FS Y I+++EN GT + V
Sbjct: 3096 LVRATDG-GGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRV 3147
Score = 161 bits (407), Expect = 2e-39
Identities = 129/462 (27%), Positives = 213/462 (46%), Gaps = 42/462 (9%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDN-DPLVFGVSGEE---ASRFFAVEPDTGVVWLRQPLDR 95
++I EDT + + Q+ A D D + L++ + + + F ++P TG ++ + LD
Sbjct: 1463 VVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDH 1522
Query: 96 ETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
E + T+ V D + R ++ + V D ND+AP F Y R+ E+ VG+ +
Sbjct: 1523 EAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
Query: 153 IVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
V A D D G VLYS + + F ID G + +ELD Y L V ATD+
Sbjct: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642
Query: 211 DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
P+S + ++ I +T + P F + YS + E G+ V ++TA Q
Sbjct: 1643 GSP-PMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS----- 1696
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDAT 329
+ Y I GNT F ++ SG + LD E P+Y+ L ++GT + + +
Sbjct: 1697 VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYT----LIIQGTNM------AGLS 1746
Query: 330 VTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL------PLFIQVVDKDENLGLN 383
TT + + D NDNAP F +EY+ I+E A + + PL I+ D D++ N
Sbjct: 1747 TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS--N 1804
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 443
++ ++V + H + +S I + LDYE + F + ++ +
Sbjct: 1805 ALLVYHIVEPSVHTYFAIDSSTGA-----IHTVLSLDYEETSIFHFTVQVHDMGTPRLFA 1859
Query: 444 ---AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
A V + +I+ ND P+F++PLY SL G V+TV
Sbjct: 1860 EYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITV 1901
Score = 160 bits (404), Expect = 4e-39
Identities = 134/460 (29%), Positives = 211/460 (45%), Gaps = 40/460 (8%)
Query: 31 FTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR 90
F FF + E PV + +++ + PL F ++G F V+ TG + +
Sbjct: 1358 FEESFFT--FTVMESDPVAHMIG-VISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVA 1414
Query: 91 QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
+PLD E KS + + +D I +V I+V D ND+ P F Y V IPE+T T
Sbjct: 1415 KPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETE 1474
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPS-----QFFAIDSARGIVTVIRELDYETTQAYQLTV 205
I ++A D D ++Y+ Q + F +D A G + +LD+E + LTV
Sbjct: 1475 ILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTV 1532
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
DQD A + + ++D D P F Y +YE + G+ V +TA+D+DK
Sbjct: 1533 MVRDQD-VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
G+ + Y+I SGN + F +D + G + LDR N + L VK T D +P
Sbjct: 1592 GKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSN---QAEYDLMVKAT---DKGSP 1645
Query: 326 SDATVTTTFNILVIDINDNA-PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
+ +T+ + + I DNA P+F S EYSV ++E +G F+ +V +S
Sbjct: 1646 PMSEITSV--RIFVTIADNASPKFTSKEYSVELSETVSIG----SFVGMVTAHSQ---SS 1696
Query: 385 MFEVYLVGNNSHHFIISP---TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
+ GN F I+P T + KA LD+ET+ Y + ++
Sbjct: 1697 VVYEIKDGNTGDAFDINPHSGTIITQKA---------LDFETLPIYTL-IIQGTNMAGLS 1746
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
V + L +ENDN P+F Q Y + E+ ++ + VLT
Sbjct: 1747 TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLT 1786
Score = 148 bits (374), Expect = 1e-35
Identities = 125/470 (26%), Positives = 208/470 (44%), Gaps = 39/470 (8%)
Query: 28 LPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVV 87
+P F F+ I+E V S V + A + + + ++ + F + +TGV+
Sbjct: 2179 MPVFEKPFYSAE--IAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVI 2236
Query: 88 WLRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
+ PLD E + + +D H V V+I V D+NDN P F Q Y+V +
Sbjct: 2237 NVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF---VDIIVDDINDNPPVFAQQSYAVTLS 2293
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSF----QPPSQFFAIDSARGIVTVIRELDYETT 198
E + +GT + V ATD D + Y F +DS+ G+++++R LDYE +
Sbjct: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
Query: 199 QAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
+ + + V A D LS+ + + +TD+ D P+F Y I EH+P G V +
Sbjct: 2354 RQHTIFVRAVDGGMPT-LSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCV 2412
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE-NPLYSHGFILTVKGT 317
A D D + Y+I+SGN + F +D +G++TL+ L P YS
Sbjct: 2413 KAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYS---------- 2462
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
LN + +T ++ VI N ++P F +EY V + E A + L ++V D
Sbjct: 2463 -LNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLH---TLVMEVKTTD 2518
Query: 378 ENLGLNSMFEVYLVGN-NSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE 435
+ G+ ++V + F I+ +I LD ET ++ +
Sbjct: 2519 GDSGIYGHVTYHIVNDFAKDRFYINERG-------QIFTLEKLDRETPAEKVISVRLMAK 2571
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
V + V + L ++NDN P F Y +++ + GTSV+ VL S
Sbjct: 2572 DAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
Score = 140 bits (352), Expect = 4e-33
Identities = 132/476 (27%), Positives = 214/476 (44%), Gaps = 42/476 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGE---EASRFFAVEP 82
P F + ++ +++ E+ P GS V Q+ A D D N +++ + E FA+
Sbjct: 2807 PVFESSPYEAFIV--ENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINM 2864
Query: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPTFHNQPYS 138
+TG + + LD E + + ++ SDH I T V++ V DVND+ P F + Y
Sbjct: 2865 ETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYK 2924
Query: 139 VRIPENTPVGTPIFIVNATDPD---LGAGGSVLYSFQPPSQFFAIDSARGI--VTVIREL 193
+ E+ P G I I++ TD D + + + P FA+++ + V V + L
Sbjct: 2925 GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPL 2984
Query: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
D E Y LT+ ATD S+ A + + + D D P+ YS I E PG
Sbjct: 2985 DREKRDNYLLTITATDGT----FSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGK 3040
Query: 254 TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
+ I+A D D I YT++ F L+ +G L + LDRE H L
Sbjct: 3041 LIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYH---LL 3096
Query: 314 VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV 373
V+ T+ + +T D+NDNAPEF++ Y++ + E + G L +V
Sbjct: 3097 VRATDGGGRFCQASIVLTLE------DVNDNAPEFSADPYAITVFENTEPG---TLLTRV 3147
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
D + GLN L+ + F I+ S I++ PLD E Y L A
Sbjct: 3148 QATDADAGLNRKILYSLIDSADGQFSINELSGI------IQLEKPLDRELQAVYTLSLKA 3201
Query: 434 -NESVPDHV-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
++ +P + V +++++ NDN P+F Y ++ E++ VGT VL V + R
Sbjct: 3202 VDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASR 3257
Score = 128 bits (322), Expect = 1e-29
Identities = 124/465 (26%), Positives = 214/465 (46%), Gaps = 46/465 (9%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLR-QPLD 94
Y I E++P SV Q+ A D D ND L++ ++ FF++ P TG++ + LD
Sbjct: 1145 YPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLD 1204
Query: 95 RETKSEFTVEFSVSDH----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT- 149
RE + E +E +V+D+ + I R + +++ D NDN P F + Y +R+PE
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRE 1263
Query: 150 ------PIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
P++ V ATD D G + YS + ++ F I+ G+V+ R + Y
Sbjct: 1264 RNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEY 1320
Query: 202 Q-LTVNATDQDKTRPLSTLA-NLAIIITDVQDMDPIFINLPYST-NIYEHSPPGTTVRII 258
L++ A D + + ST ++ I ++PI + T + E P + +I
Sbjct: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
+ + G P + + I GN +S F +D +G + + LD E + LTV+ T+
Sbjct: 1381 SV--EPPGIP--LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQ---KSNYNLTVEATD 1433
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
T+ T I VID ND+ P+F++S+Y V I E + L I VD+DE
Sbjct: 1434 -------GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI-LQISAVDQDE 1485
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESV 437
L + + F + P + + + LD+E V ++ + ++ V
Sbjct: 1486 KNKLIYTLQSSRDPLSLKKFRLDPATGS------LYTSEKLDHEAVHQHTLTVMVRDQDV 1539
Query: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
P +A++ + + + ND+ P F+ Y +YE+ VG+ VL V
Sbjct: 1540 PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQV 1584
Score = 127 bits (320), Expect = 2e-29
Identities = 119/466 (25%), Positives = 195/466 (41%), Gaps = 43/466 (9%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTG 85
N P FT+ + L SE +GS V + A + +V+ + F + P +G
Sbjct: 1662 NASPKFTSKEYSVEL--SETVSIGSFVGMVTAHSQSS--VVYEIKDGNTGDAFDINPHSG 1717
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRK-VNIQVGDVNDNAPTFHNQPYSVRIPEN 144
+ ++ LD ET +T+ ++ G+ T V + + D NDNAP F Y+ I E+
Sbjct: 1718 TIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISES 1777
Query: 145 TPVGTPIF-------IVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDY 195
+ + + ++ A D D + ++Y PS +FAIDS+ G + + LDY
Sbjct: 1778 ASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDY 1837
Query: 196 ETTQAYQLTVNATDQDKTRPLSTLA-NLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTT 254
E T + TV D R + A N+ + + D+ D P+F Y ++ + G
Sbjct: 1838 EETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVK 1897
Query: 255 VRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTV 314
V + A D D + Y+I GN F++DY +G LT+ + + LTV
Sbjct: 1898 VITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRS-----RYELTV 1952
Query: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVV 374
+ +D R T+ I V + ++ +F YS + E + L + I +
Sbjct: 1953 RA---SDGRFAG----LTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAV-ITAI 2004
Query: 375 DKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL-FA 433
N L Y + N F IS TS + P D E + +D +
Sbjct: 2005 GNPINEPL-----FYHILNPDRRFKISRTS-----GVLSTTGTPFDREQQEAFDVVVEVT 2054
Query: 434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
E P V + VK+ + ++NDN P+F N+ Y V V T V
Sbjct: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVF----VNLPYYAVVKVDTEV 2096
Score = 126 bits (317), Expect = 4e-29
Identities = 123/470 (26%), Positives = 205/470 (43%), Gaps = 36/470 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTG 85
P F ++ ISE P G VT + A D D+ D L + + + F ++ TG
Sbjct: 2388 PLFEQQIYEAR--ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG 2445
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
++ L K +++ SVSD + +V++ V N ++P F Y V + EN
Sbjct: 2446 IITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID----SARGIVTVIRELDYETTQAY 201
P+ T + V TD D G G V Y FA D + RG + + +LD ET
Sbjct: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVND---FAKDRFYINERGQIFTLEKLDRETPAEK 2562
Query: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
++V +D ++ + +I+TD D P F Y NI + GT+V + A
Sbjct: 2563 VISVRLMAKDAGGKVA-FCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
Query: 262 DQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLN-GLLDRENPLYSHGFILTVKGTE 318
D D+G I Y I S + ++ +SGV+T L+ EN ++ F+ V
Sbjct: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF-FVRAV---- 2676
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
D+ +PS +V + + ++ P+F+ Y+ ++E +G + L + E
Sbjct: 2677 --DNGSPSKESVVLVY-VKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI-----RAE 2728
Query: 379 NLGLNSMFEVY-LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
+ G +Y LV N+ + V + R+++ LD+ET Y F + A +
Sbjct: 2729 HSGT----VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
Query: 438 PDH--VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
DH V V I + + NDN P+F Y + EN+ G+ V+ + S
Sbjct: 2785 DDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRAS 2834
Score = 118 bits (296), Expect = 1e-26
Identities = 111/449 (24%), Positives = 192/449 (42%), Gaps = 59/449 (13%)
Query: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPY 137
F++ +TG++ + +P+ R+ + F +E + SD + + KV ++V N N P F Y
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKA--STKVLVKVLGANSNPPEFTQTAY 468
Query: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYE 196
EN P+GT + ++A DPD G G V YS + FAID G V+ LDYE
Sbjct: 469 KAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYE 528
Query: 197 -TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
+ Y L + A+D I + ++ D P+F + I G +
Sbjct: 529 LMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQI 588
Query: 256 RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL-NGLLDRENPLYSHGFILTV 314
++AID D+ + + Y I +GN F+L+ SGVL+L L+D S L +
Sbjct: 589 TTVSAIDADE--LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSF-HSLRI 645
Query: 315 KGTELNDDRTPSDATVTTTFNILVID---------------------------------- 340
T+ + TP +T + +++
Sbjct: 646 TATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFD 705
Query: 341 ---INDNAPEFNSS-EYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV--GNN 394
+N + P+F S+ + + E VG ++ +F+ D D G N VY V GN
Sbjct: 706 SHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLD--TGFNGKL-VYAVSGGNE 761
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINE 453
F+I + +++ PLD ET D+Y ++ + +P + + + +++
Sbjct: 762 DSCFMIDMETGM------LKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDA 815
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTV 482
NDN P F Q Y + + E+ V + ++ V
Sbjct: 816 NDNPPEFLQESYFVEVSEDKEVHSEIIQV 844
Score = 118 bits (296), Expect = 1e-26
Identities = 119/497 (23%), Positives = 210/497 (42%), Gaps = 74/497 (14%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLV-FGVSGEEASRFFAVEPDTGVVWLRQPL--DRETK 98
I D VG +T + A D D LV + + FF++ P++GV+ L++ L K
Sbjct: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
Query: 99 SEF-TVEFSVSDHQGVIT------------RKVNIQVGD--------------------- 124
F ++ + +D + T + VN+Q +
Sbjct: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
Query: 125 -----------VNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ 172
VN + P F + P +++ EN PVG+ + +N+TD D G G ++Y+
Sbjct: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
Query: 173 PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLA-IIITDV 229
++ F ID G++ ++ LD ETT Y T+N T D P L +++ D
Sbjct: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKY--TLNITVYDLGIPQKAAWRLLHVVVVDA 815
Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI 289
D P F+ Y + E + + + A D+D G + Y+IV+ F++D +
Sbjct: 816 NDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT--DTDTFSIDSV 873
Query: 290 SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN 349
+GV+ + LDRE H L ++ + R T + + D+NDN P F
Sbjct: 874 TGVVNIARPLDRE---LQHEHSLKIEARD--QAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
Query: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA 409
Y V + E G + ++++ D D LG + L+ + +F + K
Sbjct: 929 PPNYRVKVREDLPEGTVI-MWLEAHDPD--LGQSGQVRYSLLDHGEGNFDVD------KL 979
Query: 410 DIRIRVAIPLDYETVDRYDFDLFANESVP----DHVGYAKVKITLINENDNRPIFSQPLY 465
+R+ LD+E Y+ + A + Y +V++ +NEN + P+FS +
Sbjct: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
Query: 466 NISLYENVTVGTSVLTV 482
++ E+ VG+ V+TV
Sbjct: 1040 KGTVKEDAPVGSLVMTV 1056
Score = 117 bits (292), Expect = 3e-26
Identities = 113/383 (29%), Positives = 165/383 (43%), Gaps = 36/383 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE-------EASRFFAVEPDTGVVWLRQPLD 94
+ ED P G+ + L A D D G SG+ F V+ +G V + Q LD
Sbjct: 936 VREDLPEGTVIMWLEAHDPD-----LGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD 990
Query: 95 RETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNA--PTFHNQPYSVRIPENTPVG 148
E K + + D + T V ++V DVN+N P F + + E+ PVG
Sbjct: 991 FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
Query: 149 TPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAYQLTVN 206
+ + V+A D D G + YS + S F I G++ LD E+T Y LTV
Sbjct: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVF 1110
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
ATDQ PLS+ + I + DV D P Y I E+SP +V I A D D
Sbjct: 1111 ATDQGVV-PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
+ Y I SGN F++ +G++T LDRE IL V T D+ +P
Sbjct: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQ---QDEHILEVTVT---DNGSP 1223
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQV-----GFALPLFIQVVDKDENL 380
+T+ + ++D NDN P+F Y + + E + PL+ V+ D++
Sbjct: 1224 PKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLY-HVIATDKDE 1281
Query: 381 GLNSMFEVYLVGNNSH-HFIISP 402
G N+ + N H F I P
Sbjct: 1282 GPNAEISYSIEDGNEHGKFFIEP 1304
Score = 114 bits (284), Expect = 3e-25
Identities = 120/436 (27%), Positives = 193/436 (44%), Gaps = 47/436 (10%)
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLR-QPLDRETKSEFTVEFSVSDHQ---GVITRK 117
N+PL + + + R F + +GV+ P DRE + F V V++ V
Sbjct: 2009 NEPLFYHILNPD--RRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVV 2066
Query: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF 177
V + V D NDNAP F N PY + +T VG I V A D D G G V Y + +
Sbjct: 2067 VKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEH 2126
Query: 178 FAIDSARGIVTVIRELDYET-TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF 236
F I G +++ ++ + +T + Y +TV A D + A + + IT + P+F
Sbjct: 2127 FQI-GPLGEISLKKQFELDTLNKEYLVTVVAKDGGNP---AFSAEVIVPITVMNKAMPVF 2182
Query: 237 INLPYSTNIYE----HSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV 292
YS I E HSP + + + + Y+I G+ S F +++ +GV
Sbjct: 2183 EKPFYSAEIAESIQVHSP-------VVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGV 2235
Query: 293 LTLNGLLDRE-NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSS 351
+ + LD E +P Y L+++ T D T + A V +I+V DINDN P F
Sbjct: 2236 INVIAPLDFEAHPAYK----LSIRAT---DSLTGAHAEVFV--DIIVDDINDNPPVFAQQ 2286
Query: 352 EYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS----HHFIISPTSVQG 407
Y+V ++E + +G ++ +QV D + N + GN+S H + S T +
Sbjct: 2287 SYAVTLSEASVIGTSV---VQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGL-- 2341
Query: 408 KADIRIRVAIPLDYETVDRYD-FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYN 466
I + LDYE ++ F + +P V + + + NDN P+F Q +Y
Sbjct: 2342 -----ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYE 2396
Query: 467 ISLYENVTVGTSVLTV 482
+ E+ G V V
Sbjct: 2397 ARISEHAPHGHFVTCV 2412
Score = 111 bits (277), Expect = 2e-24
Identities = 88/279 (31%), Positives = 134/279 (48%), Gaps = 20/279 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVEPDTGVVWLRQPLDRET 97
+SED VG+ V Q+ A D N + + + SG E +F +++ TG V++ + LD E+
Sbjct: 3239 VSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKF-SIDSKTGAVFIIENLDYES 3297
Query: 98 KSEFTVEFSVSDH-----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
E+ + +D V T VN+ V D+NDN P F Y+ I E+ + +
Sbjct: 3298 SHEYYLTVEATDGGTPSLSDVAT--VNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVI 3355
Query: 153 IVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
V A D D + + YS +Q F ID RG V V + LD ET Y LTV A+D
Sbjct: 3356 TVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDN 3415
Query: 211 DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK---GR 267
++T + I ++DV D P+F YS I E+ P G +V + D+D G
Sbjct: 3416 GSPPRVNT-TTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
Query: 268 PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLY 306
P +TIV+GN F ++ +LT + + +E Y
Sbjct: 3475 P--FFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHY 3511
Score = 109 bits (273), Expect = 5e-24
Identities = 101/404 (25%), Positives = 170/404 (42%), Gaps = 40/404 (9%)
Query: 93 LDRETKSEFT-VEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
L+RE K +T + ++ + V R KV +QV D ND P F YSV +PENT + T
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
I V+ATD D+G G YSF+ + FAI G++ + LDY T+ Y++ + A D+
Sbjct: 168 IARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 211 DK----TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
+ +S++A L + I + P+ + S + + P I+T D D+G
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDCDQG 284
Query: 267 RPRGI-GYTIVSGN------TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
I +IV+G+ T F V + G+ +P G+ LT+ +
Sbjct: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF---GYNLTL---QA 338
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
D TP + ++ +F Y I+E A + + ++ + +
Sbjct: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV-VMVKAIPAYSH 397
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVP 438
L ++ T + K + + E V R F E +
Sbjct: 398 L----------------RYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
D KV + ++ N N P F+Q Y + ENV +GT+V+++
Sbjct: 442 DRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSL 485
Score = 100 bits (249), Expect = 3e-21
Identities = 120/466 (25%), Positives = 199/466 (42%), Gaps = 50/466 (10%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFG------VSGEEASRFFAVEPDTGVVWLRQPLDR 95
++E+ P+ + V ++ D D+ ++G V+ RF+ E G ++ + LDR
Sbjct: 2501 LAENAPLHTLVMEVKTTDGDSG--IYGHVTYHIVNDFAKDRFYINE--RGQIFTLEKLDR 2556
Query: 96 ETKSE--FTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
ET +E +V D G + VN+ + D NDNAP F Y V I + GT +
Sbjct: 2557 ETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVV 2616
Query: 153 IVNATDPDLGAGGSVLYSFQPPSQF----FAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
V A+D D G+ + Y+ + S+ I+ G++T L + + V A
Sbjct: 2617 KVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV 2676
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
D S + I+ + P F Y+ + E P GT + +I A + G
Sbjct: 2677 DNGSPSKESVVLVYVKILPPEMQL-PKFSEPFYTFTVSEDVPIGTEIDLIRA--EHSGT- 2732
Query: 269 RGIGYTIVSGNT-----NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
+ Y++V GNT + F +D SG L L LD E + + F + + T+ DD
Sbjct: 2733 --VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKW-YQFSILARCTQ--DDH 2787
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
+ + +I V D NDN+P F SS Y I E G + IQ+ D + G N
Sbjct: 2788 ---EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRV---IQIRASDADSGTN 2841
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH--- 440
+Y + + +I ++ + I LD+E D Y + A+ DH
Sbjct: 2842 GQV-MYSLDQSQSVEVIESFAINMETG-WITTLKELDHEKRDNYQIKVVAS----DHGEK 2895
Query: 441 ---VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
A V +T+ + ND+ P F+ +Y ++ E+ G V+ +L
Sbjct: 2896 IQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG-GVIAIL 2940
Score = 97.8 bits (242), Expect = 2e-20
Identities = 113/467 (24%), Positives = 192/467 (41%), Gaps = 52/467 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E VGS V Q+ A D D N +++ + F ++P G + + LDR +
Sbjct: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQ 1630
Query: 99 SEFTVEFSVSDH----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+E+ + +D IT V I V ++ +P F ++ YSV + E +G+ + +V
Sbjct: 1631 AEYDLMVKATDKGSPPMSEIT-SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
Query: 155 NATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
A SV+Y + + F I+ G + + LD+ET Y L + T+
Sbjct: 1690 TAHSQS-----SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM-- 1742
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR-------IITAIDQDK 265
LST + + + D D P+F+ Y+ I E + + V +I A D DK
Sbjct: 1743 -AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK 1801
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
+ Y IV + ++ FA+D +G + LD E H TV+ ++ R
Sbjct: 1802 DSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFH---FTVQVHDMGTPRLF 1858
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
++ T + VIDIND P F Y ++ G + + + D D + +
Sbjct: 1859 AEYAANVTVH--VIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDADSSAFSQLI 1915
Query: 386 FEVYLVGNNSHHFIIS----PTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
+ + GN F + +VQ +R R YE R FA
Sbjct: 1916 YSI-TEGNIGEKFSMDYKTGALTVQNTTQLRSR------YELTVRASDGRFA-------- 1960
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG--TSVLTVLVSP 486
G VKI + ++ F+Q +Y+ + EN T +V+T + +P
Sbjct: 1961 GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
Score = 85.1 bits (209), Expect = 1e-16
Identities = 75/245 (30%), Positives = 104/245 (42%), Gaps = 26/245 (10%)
Query: 37 DTYL-LISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQP 92
DTY +ISED + SV ++A D D N + + + F ++P G V + +
Sbjct: 3338 DTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKL 3397
Query: 93 LDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
LDRET S +T+ SD+ V T VNI V DVNDNAP F YSV I EN PVG
Sbjct: 3398 LDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGF 3457
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSA----------RGIVTVIRELDYETTQ 199
+ + TD D G P FF I + +G++ + +
Sbjct: 3458 SVLQLVVTDEDSSHNG--------PPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKD 3509
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y L V D K + LS+L + I + + P + L G + I
Sbjct: 3510 HYLLQVKVADNGKPQ-LSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIH 3568
Query: 260 AIDQD 264
A DQD
Sbjct: 3569 ATDQD 3573
Score = 78.6 bits (192), Expect = 1e-14
Identities = 109/467 (23%), Positives = 191/467 (40%), Gaps = 59/467 (12%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPLDR 95
+ E+T + +S+ ++ A D D G +GE + + FA+ P +GV+ L LD
Sbjct: 158 LPENTAIRTSIARVSATDAD-----IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDY 212
Query: 96 ETKSEFTVEFSVSDH-------QGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ +E +D G+ + K+ + + N+ AP S + P
Sbjct: 213 LETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPA 272
Query: 148 GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYETTQ 199
IV D D GA G + + + QF + S G V I +D+++
Sbjct: 273 YA---IVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329
Query: 200 -AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
Y LT+ A D+ S++ + + + F Y I E +PP T V ++
Sbjct: 330 FGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMV 389
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
AI + Y S + F+L+Y +G++++ + R+ + F L V
Sbjct: 390 KAIPAYSH----LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH---FELEV---- 438
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
T SD +T + V+ N N PEF + Y A E +G + + + VD DE
Sbjct: 439 -----TTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTV-MSLSAVDPDE 492
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESV 437
+ + Y + N +H P ++ + + LDYE + R Y + A++
Sbjct: 493 G---ENGYVTYSIANLNH----VPFAIDHFTGA-VSTSENLDYELMPRVYTLRIRASDWG 544
Query: 438 PDHVGYAKV--KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ +V ITL N NDN P+F + ++ ++ VG + TV
Sbjct: 545 LPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 192 bits (489), Expect = 5e-49
Identities = 139/451 (30%), Positives = 222/451 (49%), Gaps = 26/451 (5%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ ED G + ++ A D+D D + + + G A F ++P TG + LDRE K
Sbjct: 3020 VHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEF-KLDPHTGELTTLTALDRERK 3078
Query: 99 SEFTVEFSVSDHQGVITRK-VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
F + +D G + + + V DVNDNAP F +V + +NT V TP+ +V A
Sbjct: 3079 DVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFAR 3138
Query: 158 DPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPL 216
DPD GA V+YS ++ F+ID+ G++ + + L +LTV A+D PL
Sbjct: 3139 DPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPL 3198
Query: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV 276
STL + + + ++D P+F+N +S + E +PPGT V + + + GY +V
Sbjct: 3199 STLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEK--TGYRVV 3256
Query: 277 SGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNI 336
SGN F LD +G+L +N LD E S + L+++ + ++ S + TT +
Sbjct: 3257 SGNEQGRFRLDARTGILYVNASLDFET---SPKYFLSIECSR----KSSSSLSDVTTVMV 3309
Query: 337 LVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS- 395
+ D+N++ P+F YS + E A VG + + V DE+ LNS L+G N
Sbjct: 3310 NITDVNEHRPQFPQDPYSTRVLENALVG---DVILTVSATDEDGPLNSDITYSLIGGNQL 3366
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINEN 454
HF I P + ++VA LD E Y L A +S P + I + + N
Sbjct: 3367 GHFTIHPKKGE------LQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVN 3420
Query: 455 DNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
DN P F Q Y+ ++ EN +G+ VL +++S
Sbjct: 3421 DNPPRFFQLNYSTTVQENSPIGSKVLQLILS 3451
Score = 167 bits (422), Expect = 3e-41
Identities = 138/454 (30%), Positives = 209/454 (46%), Gaps = 35/454 (7%)
Query: 44 EDTPVGSS---VTQLLAQDMDNDPLVFGVSGEE-ASRFFAVEPDTGVVWLRQPLDRETKS 99
ED P GS V + AQD LV G + E F+++PDTGV+ +R+P+D E+
Sbjct: 2702 EDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
Query: 100 EFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
+ ++ Q V VNIQVGDVNDN P F PY + EN PVGT + V A
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTA 2821
Query: 157 TDPDLGAGGSVLY--SFQPPS---QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
D D G G V Y S P S + FAIDS G +T ++ELD ET Q Y V A D
Sbjct: 2822 IDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHG 2881
Query: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD-KGRPRG 270
+T LS+ A + + ITD D P F + Y ++ E+S PG V + +D D + R
Sbjct: 2882 QTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQ 2941
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNG--LLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
+ I G+ F + + ++ LDRE ++ ++L V ++
Sbjct: 2942 VTCYITEGDPLGQFGISQVGDEWRISSRKTLDRE---HTAKYLLRVTASD-------GKF 2991
Query: 329 TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
+ T I V+D+NDN+P+ + Y+ + E G ++V D + N+
Sbjct: 2992 QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH---FILKVSATDLDTDTNAQITY 3048
Query: 389 YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKI 448
L G +H F + P + + + LD E D ++ A + A + +
Sbjct: 3049 SLHGPGAHEFKLDPHTGE------LTTLTALDRERKDVFNLVAKATDG-GGRSCQADITL 3101
Query: 449 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ + NDN P F +++++N TV T V V
Sbjct: 3102 HVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV 3135
Score = 160 bits (405), Expect = 3e-39
Identities = 126/450 (28%), Positives = 215/450 (47%), Gaps = 35/450 (7%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPL 93
L ISEDT VG+++ +L +D D++ +G + F++ P TG + + L
Sbjct: 827 LTISEDTEVGTTIAELTTKDADSED-----NGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881
Query: 94 DRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
DRE++ + ++ D HQ + I + DVNDN+P + +++PE+ P G
Sbjct: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
Query: 149 TPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
T + ++A+DPDLG G V Y + F +D G + + RELD+E Y L++ A
Sbjct: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001
Query: 208 TDQDKTRPLSTLANLAIIITDVQDM--DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
+D + TL ++ +I+ DV + P F + + + E+SP GT V ++ A D D
Sbjct: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
G + Y + +G + F+++ +G++ LDRE Y +L V DR
Sbjct: 1062 GLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV-------DRGS 1114
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ T I V D NDN P+ + + + +I E A VG ++ L + D D +
Sbjct: 1115 VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV-LQLDAWDPDSSSKGKLT 1173
Query: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYA 444
F + GN F+I P + + A LD E D + ++ + P +
Sbjct: 1174 FNI-TSGNYMGFFMIHPVTGL------LSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS 1226
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVT 474
+V + +++ NDN PIFS L+N+ L E ++
Sbjct: 1227 RVVVGILDVNDNPPIFSHKLFNVRLPERLS 1256
Score = 149 bits (375), Expect = 8e-36
Identities = 136/470 (28%), Positives = 215/470 (45%), Gaps = 31/470 (6%)
Query: 24 QVNRL-PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFA 79
Q+N P F +HF + + + E P+ + + +L A D D N LV+ ++ F
Sbjct: 706 QINHYTPQFEDHFPQS-IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Query: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP 136
+E +TG++ + PLD E + + + +V D Q + + + V D NDNAP F
Sbjct: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
Query: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE 196
Y + I E+T VGT I + D D G V Y+ P++ F++ G + V LD E
Sbjct: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Query: 197 TTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
+ Y L V A DQ K L ++ +L I + DV D P I + E PPGT +
Sbjct: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVL 944
Query: 256 RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
+ A D D G + Y ++ G + F +D ++G L L LD E G+ L++
Sbjct: 945 TFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFER---RAGYNLSLW 1000
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQV 373
+D P ++V+D+N+N P F S + + E + G + I V
Sbjct: 1001 A---SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV---IVV 1054
Query: 374 VDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
+D++ GL+ + +L G F I+ + I+ PLD E Y +
Sbjct: 1055 AAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM------IQTLAPLDREFASYYWLTVL 1108
Query: 433 ANE--SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
A + SVP +V I + + NDN P SQ ++ S+ E+ VGTSVL
Sbjct: 1109 AVDRGSVP-LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL 1157
Score = 142 bits (359), Expect = 6e-34
Identities = 125/465 (26%), Positives = 204/465 (43%), Gaps = 35/465 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVW 88
P F + ++ + + E+ + + + A+ + L++ + EE F + TGV+
Sbjct: 2169 PLFQSPYYK--VRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLT 2226
Query: 89 LRQPLDRETKSE--FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
+ PLD E+K++ FTV + + V + V DVNDN PTF Y+ I E P
Sbjct: 2227 VTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLP 2286
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSF----QPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
TP+ + A+D D G V Y S+FF I+ + G ++ ++ELDYE Q +
Sbjct: 2287 AQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFH 2346
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAID 262
+ V A D+ PL+ + + ++D+ D P F Y N+ E + G V + AID
Sbjct: 2347 VKVRAMDKGDP-PLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAID 2405
Query: 263 QDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDD 322
D + Y I+SGN + F ++ SG++++ L + + L V
Sbjct: 2406 PDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKH---LDSSYNLRVGA------ 2456
Query: 323 RTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
SD T + + N N +PEF Y + E A VG + + + +DKD
Sbjct: 2457 ---SDGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV-IDLLAIDKDS-- 2510
Query: 381 GLNSMFEVYLVGN-NSHHFIISPTSVQGKADIRIRVAIPLDYE-TVDRYDFDLFANESVP 438
G + ++ S F I+P +I LD E + +R
Sbjct: 2511 GPYGTIDYTIINKLASEKFSINPNG-------QIATLQKLDRENSTERVIAIKVMARDGG 2563
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V + VKI L +ENDN P F Y +S+ NV+ + V+ VL
Sbjct: 2564 GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
Score = 133 bits (335), Expect = 4e-31
Identities = 118/399 (29%), Positives = 179/399 (44%), Gaps = 36/399 (9%)
Query: 94 DRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
DRE + + V D+ Q V V + + DVNDN P F + PY I + T G
Sbjct: 2029 DREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
+F V+ATD DLG G+V Y F +F ID G +++ + DY+ Y L V A D
Sbjct: 2089 LFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG 2148
Query: 211 DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR-PR 269
S + +++T +P+F + Y + E+ + + T I + R P
Sbjct: 2149 GTP---SLQSEEEVLVTVRNKSNPLFQSPYYKVRVPEN------ITLYTPILHTQARSPE 2199
Query: 270 GIG--YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
G+ Y IV +F D+ +GVLT+ G LD E+ H F + T L + S+
Sbjct: 2200 GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKT-KHVFTVRATDTALG---SFSE 2255
Query: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPL---FIQVVDKDENLGLNS 384
ATV +LV D+NDN P F+ Y+ +I+E LP IQ++ D++ G N
Sbjct: 2256 ATV----EVLVEDVNDNPPTFSQLVYTTSISE------GLPAQTPVIQLLASDQDSGRNR 2305
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGY 443
+V + S + + G + LDYE + + A ++ P G
Sbjct: 2306 DVSYQIVEDGSD--VSKFFQINGSTG-EMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGE 2362
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
V + + + NDN P F QP Y ++ E T G VL V
Sbjct: 2363 TLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV 2401
Score = 126 bits (317), Expect = 4e-29
Identities = 118/484 (24%), Positives = 213/484 (44%), Gaps = 56/484 (11%)
Query: 10 HVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGV 69
H+ W+ W + + +P + + ++ ++ D PV V + + F +
Sbjct: 1333 HIEWIP------WPRPSSIPLAFDETYYSFTVMETD-PVNHMVGVISVEGRPG-LFWFNI 1384
Query: 70 SGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI-QVGDVNDN 128
SG + F +E TG + + +PLD +S + + V+D I +V+I + ++N +
Sbjct: 1385 SGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHH 1444
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF---QPP--SQFFAIDSA 183
P F Y VR+P++T G + V A D D G S++Y+ Q P + F +D +
Sbjct: 1445 RPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK--SLIYTIHGSQDPGSASLFQLDPS 1502
Query: 184 RGIVTVIRELDYETTQA-YQLTVNATDQDKTRPLSTLANLAIIITDVQDMD---PIFINL 239
G++ + +LD + + + LTV DQ+ + N + V+D + P F L
Sbjct: 1503 SGVLVTVGKLDLGSGPSQHTLTVMVRDQE----IPIKRNFVWVTIHVEDGNLHPPRFTQL 1558
Query: 240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLL 299
Y ++ + PGT + + A+D D+G + Y+++ GN+ F ++ + G++TL L
Sbjct: 1559 HYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKL 1618
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
D+ N LTVK + + ATV I V + +AP F+ SEY V I E
Sbjct: 1619 DQAN---HAPHTLTVKAEDQGSPQWHDLATVI----IHVYPSDRSAPIFSKSEYFVEIPE 1671
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
VG + L + + L + + NS+ +IS L
Sbjct: 1672 SIPVGSPILLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQK-------------KL 1718
Query: 420 DYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIF-----------SQPLYNIS 468
D+E + Y + ++ V + +I+ENDN P+F + PLY++
Sbjct: 1719 DHEKISSYQLKI-RGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMI 1777
Query: 469 LYEN 472
+ +N
Sbjct: 1778 MDKN 1781
Score = 125 bits (314), Expect = 1e-28
Identities = 109/371 (29%), Positives = 175/371 (47%), Gaps = 19/371 (5%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPL--VFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
L + ED P G+ +T L A D D P V V + A F V+ TG + L + LD E
Sbjct: 932 LKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFER 991
Query: 98 KSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNA--PTFHNQPYSVRIPENTPVGTPI 151
++ + + SD + R+ V + V DVN+N P F + + ++ EN+P GT +
Sbjct: 992 RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV 1051
Query: 152 FIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
+V A D D G G + Y + + F+I+ G++ + LD E Y LTV A D
Sbjct: 1052 IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
+ PLS++ + I +TD D P + +I E +P GT+V + A D D
Sbjct: 1112 RGSV-PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKG 1170
Query: 270 GIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDAT 329
+ + I SGN F + ++G+L+ LDREN H +TV D+ PS
Sbjct: 1171 KLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENK-DEHILEVTVL-----DNGEPS-LK 1223
Query: 330 VTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVY 389
T+ + ++D+NDN P F+ ++V + E P++ ++V D + GLN
Sbjct: 1224 STSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY-RLVASDLDEGLNGRVTYS 1282
Query: 390 LVGNNSHHFII 400
+ ++ F I
Sbjct: 1283 IEDSDEEAFSI 1293
Score = 123 bits (309), Expect = 4e-28
Identities = 126/458 (27%), Positives = 208/458 (45%), Gaps = 37/458 (8%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95
Y I ED PVG+SV QL A D D+ L F ++ FF + P TG++ Q LDR
Sbjct: 1143 YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDR 1202
Query: 96 ETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN-TPVGT-P 150
E K E +E +V D+ T +V + + DVNDN P F ++ ++VR+PE +PV P
Sbjct: 1203 ENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP 1262
Query: 151 IFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
++ + A+D D G G V YS + + F+ID G+V+ + + LT+ ATD
Sbjct: 1263 VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVS--SSSTFTAGEYNILTIKATD 1320
Query: 210 QDKTRPLSTLANLAI--IITDVQDMDPI-FINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
+ PLS L I I P+ F YS + E P V +I+ +G
Sbjct: 1321 SGQP-PLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV----EG 1375
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
RP + I G+ + F ++ +G + + LD + LTV+ T+
Sbjct: 1376 RPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRR---RSNYNLTVEVTD-------G 1425
Query: 327 DATVTTTFNILVI-DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
T+ T +I +I +IN + P+F + Y V + + G L L +Q +D+D+ L
Sbjct: 1426 SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVEL-LRVQAIDQDKGKSL--- 1481
Query: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVA-IPLDYETVDRYDFDLFANESVPDHVGYA 444
+Y + + S + + + + V + L + ++ +P +
Sbjct: 1482 --IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
V I + + N + P F+Q Y S+ + + GT +L V
Sbjct: 1540 WVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
Score = 114 bits (285), Expect = 2e-25
Identities = 112/476 (23%), Positives = 203/476 (42%), Gaps = 45/476 (9%)
Query: 42 ISEDTPVGSSVTQL-LAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
+SE +P GS V + + N V S E F + TG++ + +D ++
Sbjct: 371 LSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG--FKLNARTGLITTTKLMDFHDRAH 428
Query: 101 FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPD 160
+ + S Q + V I + D N++AP F+ Y + EN P GT + V ATD D
Sbjct: 429 YQLHIRTSPGQA--STVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486
Query: 161 LGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYE-TTQAYQLTVNATDQDKTRPLST 218
G G V YS P F+ID GI++ + +DYE + Y V A+D
Sbjct: 487 HGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREK 546
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
++ + + ++ D P+F + + +I + P G ++ ++AID D+ + + Y IVSG
Sbjct: 547 EVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE--LQNLKYEIVSG 604
Query: 279 NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVT------- 331
N F L++ SGV++L + L + ++ + +P+ +T
Sbjct: 605 NELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHF 664
Query: 332 ------------TTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPL----FIQVVD 375
T F ++ + +S E +++ Q+ P F Q +D
Sbjct: 665 EVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY-QINHYTPQFEDHFPQSID 723
Query: 376 KDENLGLNSMFEVYLVG------NNSHHFIISPTSVQGKADIRIR-----VAIPLDYETV 424
E++ +N+ N ++I+ + +G DI + VA PLDYE
Sbjct: 724 VLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEAT 783
Query: 425 DRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
+ Y ++ + P + + + + + NDN P F Y +++ E+ VGT++
Sbjct: 784 NFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI 839
Score = 110 bits (274), Expect = 4e-24
Identities = 118/464 (25%), Positives = 194/464 (41%), Gaps = 40/464 (8%)
Query: 41 LISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLD 94
+++E+ PVG+SV Q+ A D D + + + +S G FA++ ++G + Q LD
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELD 2864
Query: 95 RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
ET + DH I V + + D NDNAP F ++ Y + EN+ G
Sbjct: 2865 CETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGEL 2924
Query: 151 IFIVNATDPDLGAGGSVLYSF----QPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTV 205
+ + D D+ + + P QF + ++ + LD E T Y L V
Sbjct: 2925 VATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRV 2984
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A+D + I + DV D P L Y+ ++E PG + ++A D D
Sbjct: 2985 TASD----GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
I Y++ + F LD +G LT LDRE F L K T+
Sbjct: 3041 DTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRER---KDVFNLVAKATDGGGRSCQ 3096
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+D T + V D+NDNAP F S +VA+ + V + + V +D + G N+
Sbjct: 3097 ADIT------LHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAV---VFARDPDQGANAQ 3147
Query: 386 FEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 443
L + HF I T+ ++ + +++R PL+ TV D S
Sbjct: 3148 VVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL-TVRASDLGTPIPLST-----L 3201
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
V ++++ D P+F +++ + E+ GT VL + R
Sbjct: 3202 GTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR 3245
Score = 109 bits (272), Expect = 7e-24
Identities = 117/486 (24%), Positives = 203/486 (41%), Gaps = 55/486 (11%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
++ I E PVGS + LL M + + + F++ +G++ ++ LD E
Sbjct: 1666 FVEIPESIPVGSPI--LLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI 1723
Query: 99 SEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI------ 151
S + ++ S+ G T V + + D NDNAP F + +I E P+ + I
Sbjct: 1724 SSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN 1783
Query: 152 -FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
F+++A+D D A ++Y P +FF ID + G +T++ E+DYE+ ++Q V
Sbjct: 1784 PFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVH 1843
Query: 209 DQDK-----TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
DQ RP A + I + DV D P F Y I PG + ++ A D+
Sbjct: 1844 DQGSPVLFAPRP----AQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899
Query: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
D + Y+I +GN + + ++G +++ NP + L+ K T D
Sbjct: 1900 DS----EVNYSIKTGNADEAVTIHPVTGSISV------LNPAF---LGLSRKLTIRASDG 1946
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
D T I + + D + +F+ Y A+ E Q AL V+ + LN
Sbjct: 1947 LYQD---TALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL-----VILGAQGNHLN 1998
Query: 384 SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
+L+ G + H + S +Q + + D E D ++ + ++ P V
Sbjct: 1999 DTLSYFLLNGTDMFHMVQSAGVLQTR-------GVAFDREQQDTHELAVEVRDNRTPQRV 2051
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTAGPLSSPGPTVV 501
V++++ + NDN P F ++ Y + GT VL T L + G
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFK----HLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTY 2107
Query: 502 RHPEGF 507
E +
Sbjct: 2108 EFAEDY 2113
Score = 104 bits (259), Expect = 2e-22
Identities = 122/500 (24%), Positives = 205/500 (41%), Gaps = 77/500 (15%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN-DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
I +D PVG S+ + A D+D L + + +F + +GV+ L++P T +
Sbjct: 573 IRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ 632
Query: 101 ---FTVEFSVSDHQ---------------------------GVITRKV------------ 118
++++ + SD + GV+T+
Sbjct: 633 PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQ 692
Query: 119 --------NIQVGDVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY 169
++ +N P F + P S+ + E+ P+ TP+ + ATDPD G G ++Y
Sbjct: 693 ESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVY 752
Query: 170 SFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
++ F I+ G++TV LDYE T Y L V D T S+ L + +
Sbjct: 753 VIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVK 811
Query: 228 DVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALD 287
D D P F Y I E + GTT+ +T D D + YT++S F+L
Sbjct: 812 DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLH 869
Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI-DINDNAP 346
++G L + G LDRE+ +IL V E D + + T I+ + D+NDN+P
Sbjct: 870 PLTGELVVTGHLDRES---EPRYILKV---EARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
Query: 347 EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
+ + + + E G L F+ D D L EV V + H +
Sbjct: 924 QCITEHNRLKVPEDLPPGTVLT-FLDASDPD----LGPAGEVRYVLMDGAHGTFRVDLMT 978
Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQ 462
G + LD+E Y+ L+A++ + + +V + +NEN + P F+
Sbjct: 979 GALILERE----LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS 1034
Query: 463 PLYNISLYENVTVGTSVLTV 482
++ + EN GT V+ V
Sbjct: 1035 FVHQGQVQENSPSGTQVIVV 1054
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/450 (22%), Positives = 190/450 (42%), Gaps = 27/450 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+SE G V ++ A D D+ L + + R F + +G++ + +
Sbjct: 2388 VSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD 2447
Query: 99 SEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATD 158
S + + SD T V I + N +P F Y + EN VGT + + A D
Sbjct: 2448 SSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
Query: 159 PDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPL 216
D G G++ Y+ + S+ F+I + G + +++LD E + + + +D +
Sbjct: 2508 KDSGPYGTIDYTIINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARDGGGRV 2566
Query: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV 276
+ + II+TD D P F Y+ +I + + V + A D D+G+ + Y++
Sbjct: 2567 A-FCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN 2625
Query: 277 SGN-TNSIFALDYISGVLTL-NGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
+ + ++ ++GV+ + + L+ EN F + + D P
Sbjct: 2626 PEDLVKDVIEINPVTGVVKVKDSLVGLENQTLD--FFIKAQ------DGGPPHWNSLVPV 2677
Query: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
+ V+ + P+F+ Y+ + E G + + ++ V + + + + N
Sbjct: 2678 RLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-VKAVAAQDPVIYSLVRGTTPESNK 2736
Query: 395 SHHFIISP-TSVQGKADIRIRVAIPLDYETVDRYDFDLFAN-ESVPDHVGYAKVKITLIN 452
F + P T V I+V P+D+E+ Y D+ A+ D V V I + +
Sbjct: 2737 DGVFSLDPDTGV-------IKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGD 2789
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
NDNRP+F Y L EN+ VGTSV+ V
Sbjct: 2790 VNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
Score = 89.4 bits (220), Expect = 8e-18
Identities = 115/470 (24%), Positives = 196/470 (41%), Gaps = 43/470 (9%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGV--SGEEASRFFAVEPD 83
P F++ F+ L V +L+A D+D N + + + S EEA F+++
Sbjct: 1240 PIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEA---FSIDLV 1296
Query: 84 TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPT-----FHNQPYS 138
TGVV + T++ + S Q ++ V + + + P+ F YS
Sbjct: 1297 TGVVSSSSTFTAGEYNILTIKATDSG-QPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ--PPSQFFAIDSARGIVTVIRELDYE 196
+ E PV + +++ G G ++ F I+ G + + R LD
Sbjct: 1356 FTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
Query: 197 TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
Y LTV TD +T ++T ++ +I ++ P F+ Y + + + PG +
Sbjct: 1412 RRSNYNLTVEVTDGSRT--IATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELL 1468
Query: 257 IITAIDQDKGRPRGIGYTIVSGN---TNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
+ AIDQDKG+ + YTI + S+F LD SGVL G LD + H +
Sbjct: 1469 RVQAIDQDKGK--SLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVM 1526
Query: 314 VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV 373
V+ E+ R T+ V D N + P F Y ++ + G L +QV
Sbjct: 1527 VRDQEIPIKRNFVWVTIH------VEDGNLHPPRFTQLHYEASVPDTIAPGTEL---LQV 1577
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
D + G+N+ L+ NS F ++ I I +A LD + + A
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFF----NINALLGI-ITLAQKLDQANHAPHTLTVKA 1632
Query: 434 -NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
++ P A V I + + + PIFS+ Y + + E++ VG+ +L V
Sbjct: 1633 EDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLV 1682
Score = 88.6 bits (218), Expect = 1e-17
Identities = 104/440 (23%), Positives = 171/440 (38%), Gaps = 27/440 (6%)
Query: 47 PVGSSVTQLLAQDMDNDPLV-FGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEF 105
P+ + L+ + D D V + + A + P TG + + P + T+
Sbjct: 1884 PIHPGMELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIRA 1943
Query: 106 SVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGG 165
S +Q T V I + V D + F Y + EN + I+ A L
Sbjct: 1944 SDGLYQD--TALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTL 2001
Query: 166 SVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAII 225
S + F + SA + T D E ++L V D ++T + +
Sbjct: 2002 SY-FLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRD-NRTPQRVAQGLVRVS 2059
Query: 226 ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFA 285
I DV D P F +LPY T I + + PG + ++A D+D G + Y T F
Sbjct: 2060 IEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT--YFR 2117
Query: 286 LDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNA 345
+D G ++L D + H ++ D TPS + + +LV N +
Sbjct: 2118 IDPYLGDISLKKPFDYQALNKYHLKVIA------RDGGTPS---LQSEEEVLVTVRNKSN 2168
Query: 346 PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSV 405
P F S Y V + E + P+ E L L +Y + + +
Sbjct: 2169 PLFQSPYYKVRVPE--NITLYTPILHTQARSPEGLRL-----IYNIVEEEPLMLFTTDFK 2221
Query: 406 QGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLY 465
G + V PLDYE+ ++ F + A ++ A V++ + + NDN P FSQ +Y
Sbjct: 2222 TGV----LTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVY 2277
Query: 466 NISLYENVTVGTSVLTVLVS 485
S+ E + T V+ +L S
Sbjct: 2278 TTSISEGLPAQTPVIQLLAS 2297
Score = 80.9 bits (198), Expect = 3e-15
Identities = 97/407 (23%), Positives = 170/407 (41%), Gaps = 40/407 (9%)
Query: 93 LDRETKSEFTVEFSVSDHQ---GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
L+RE + +T+ ++ +TR V + + D ND P F Y V I E+ P+ +
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
PI V ATD DLG Y+F S+ FAI G+VTV +L+ ++L V A
Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAV- 224
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP---PGTTVRIITAIDQDKG 266
D+ R +S + V ++P P ++ P GTT + +D +
Sbjct: 225 -DRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATV-LVDANSS 282
Query: 267 RPRGIGYTIVSGNTNSIFAL--DYI-SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
+V G+ F Y S +L + D Y HGF L++ +
Sbjct: 283 GAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL---QARSGS 339
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
P + F++ + ++ +F + Y V ++E + G + + ++V NL
Sbjct: 340 GPYFYSQIRGFHLPPSKL--SSLKFEKAVYRVQLSEFSPPGSRV-VMVRVTPAFPNL--- 393
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---FDLFANESVPDH 440
+++ P+S + R + + +D +D + L S P
Sbjct: 394 -------------QYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-PGQ 439
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
V I +++ N++ P+F++ Y+ +L EN+ GTSVL V + R
Sbjct: 440 AS-TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDR 485
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/249 (27%), Positives = 109/249 (43%), Gaps = 21/249 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F + T +L E+ VG + + A D D N + + + G F + P G
Sbjct: 3319 PQFPQDPYSTRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKG 3376
Query: 86 VVWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
+ + + LDRE S ++++ +D H+ + IQV DVNDN P F YS
Sbjct: 3377 ELQVAKALDREQASSYSLKLRATDSGQPPLHEDT---DIAIQVADVNDNPPRFFQLNYST 3433
Query: 140 RIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ----PPSQFFAIDSARGIVTVIRELDY 195
+ EN+P+G+ + + +DPD G YSF+ F + +VT L
Sbjct: 3434 TVQENSPIGSKVLQLILSDPDSPENGPP-YSFRITKGNNGSAFRVTPDGWLVTA-EGLSR 3491
Query: 196 ETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
+ YQL + A+D PLS+L ++ + +T+ P + L + E G V
Sbjct: 3492 RAQEWYQLQIQASDSG-IPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMV 3550
Query: 256 RIITAIDQD 264
I A D+D
Sbjct: 3551 GKIHATDRD 3559
Score = 64.3 bits (155), Expect = 3e-10
Identities = 107/461 (23%), Positives = 188/461 (40%), Gaps = 51/461 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
ISED P+ S + ++ A D D F + S FA+ P +GVV + L+ + +
Sbjct: 157 ISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGK 216
Query: 101 FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE-NTPVGTPIFIVNATD- 158
++ D RK++ G + A H +P + P + V TP + T
Sbjct: 217 HELQVLAVDRM----RKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTY 272
Query: 159 ----PDLGAGGSVLYSFQ-----PPSQFFAIDS-ARG---IVTVIRELDY-ETTQAYQLT 204
D + G+ + S + P F AI S AR + ++++++ E + L+
Sbjct: 273 ATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLS 332
Query: 205 VNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
+ A S + + + + + F Y + E SPPG+ V ++
Sbjct: 333 LQARSGSGPYFYSQIRGFHLPPSKLSSLK--FEKAVYRVQLSEFSPPGSRVVMVRVTPAF 390
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
+ Y + + N F L+ +G++T L+D + + I T G
Sbjct: 391 PN----LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ------- 439
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
+T I ++D N++AP FN S Y + E G ++ L + D+D G N
Sbjct: 440 -----ASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSV-LAVTATDRDH--GENG 491
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESVPDHVGY 443
+ G + F I P I + P+DYE + R Y F + A++
Sbjct: 492 YVTYSIAGPKALPFSIDPYLGI------ISTSKPMDYELMKRIYTFRVRASDWGSPFRRE 545
Query: 444 AKVKI--TLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+V I L N NDN+P+F + S+ ++ VG S++T+
Sbjct: 546 KEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTM 586
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 191 bits (484), Expect = 2e-48
Identities = 148/461 (32%), Positives = 234/461 (50%), Gaps = 26/461 (5%)
Query: 41 LISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
L+ ED P + ++ A+D D N + + + G S FF ++P++G + LDRE
Sbjct: 3037 LLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRER 3095
Query: 98 KSEFTVEFSVSDHQGVITRK-VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
+++ +D G + +++ + DVNDN P F + Y+ + ENT + V A
Sbjct: 3096 IPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQA 3155
Query: 157 TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
DPD+G V+YS + F+IDS+ GI+ + + LD E +Y ++V ATDQ +
Sbjct: 3156 VDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQS 3215
Query: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
LS+L + I + D+ D P+F Y + E + PGT V + A +D G I Y I
Sbjct: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLI 3275
Query: 276 VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFN 335
SGN F ++ +G ++++ +LD E F L V E D TP+ + V T N
Sbjct: 3276 RSGNEQGKFKINPKTGGISVSEVLDYE---LCKRFYLVV---EAKDGGTPALSAVATV-N 3328
Query: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI-QVVDKDENLGLNSMFEVYLVGNN 394
I + D+NDN P+F+ YS I+E A VG ++ L I + VD N ++ F + + G+
Sbjct: 3329 INLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIH--FSI-VNGDR 3385
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINE 453
+ F + P V G ++V LD E V Y + A +S +P A V I + +
Sbjct: 3386 DNEFTVDP--VLG----LVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR--FTAGP 492
NDN P+F+ Y + EN VGTS+L ++V+ R F GP
Sbjct: 3440 NDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGP 3480
Score = 181 bits (458), Expect = 2e-45
Identities = 137/468 (29%), Positives = 232/468 (49%), Gaps = 25/468 (5%)
Query: 25 VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVE 81
+NR + + F + + + ED PVG+++ ++ A D D N ++F +S F ++
Sbjct: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
Query: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYS 138
+TG + + P+DRE + + ++ D Q R + I V D NDN+P F YS
Sbjct: 778 METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYS 837
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETT 198
V I E++ +GT I V A D DLG+ G V YS +Q FAI+S+ GIV V +LD E+
Sbjct: 838 VNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESK 897
Query: 199 QAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
Y L + A D+ + + L ++ L + + DV D P FI YS + E P GT +
Sbjct: 898 ANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAW 957
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ D D G + Y++V+ + N F +D SG + L+ LD E + + LTV+
Sbjct: 958 LETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQF---YNLTVRA- 1012
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVD 375
D P + + + V+D+N+N P F ++ E +++G ++ +QV
Sbjct: 1013 --KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV---LQVTA 1067
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
+DE+ G + + Y + + S + S+ ++ + I A LD ET+ Y ++A +
Sbjct: 1068 RDEDSGRDGEIQ-YSIRDGSG---LGRFSIDDESGV-ITAADILDRETMGSYWLTVYATD 1122
Query: 436 -SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
V +V I + + NDN P+ S+P+Y + EN SV+ +
Sbjct: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Score = 170 bits (431), Expect = 3e-42
Identities = 142/472 (30%), Positives = 218/472 (46%), Gaps = 43/472 (9%)
Query: 28 LPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFG-VSGEEASR----FFAVEP 82
LP FT + I+EDT +GS+V L N + F V+GE F +E
Sbjct: 2705 LPSFTQSQYS--FTIAEDTAIGSTVDTLRILPSQN--VWFSTVNGERPENNKGGIFVIEQ 2760
Query: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVI-TRKVNIQVGDVNDNAPTFHNQPYS 138
+TG + L + LDRET F + + + D ++ T V+I+V D+NDN P F Y
Sbjct: 2761 ETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYD 2820
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ------FFAIDSARGIVTVIRE 192
I E PVGT + V A D D GA G V YS SQ F IDS G ++ +++
Sbjct: 2821 TIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD 2880
Query: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
LD+ET + +V A+D + LS+ A +++ +TD+ D P+F Y N+ E PPG
Sbjct: 2881 LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG 2940
Query: 253 TTVRIITAIDQDKGR-PRGIGYTIVSGNTNSIFALDYISG--VLTLNGLLDRENPLYSHG 309
V +++ D+D R + Y I GN FAL + + + LDRE
Sbjct: 2941 EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREE---QDI 2997
Query: 310 FILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPL 369
+ L + T D + A V + V D+NDN+P + Y+ + E + +
Sbjct: 2998 YFLNITAT---DGLFVTQAMV----EVSVSDVNDNSPVCDQVAYTALLPEDIP---SNKI 3047
Query: 370 FIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
++V KD ++G N L G+ + F + P S + ++ LD E + Y
Sbjct: 3048 ILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGE------LKTLALLDRERIPVYSL 3101
Query: 430 DLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
A + + + + L + NDN P+FS YN +YEN T ++LT
Sbjct: 3102 MAKATDG-GGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYEN-TATKALLT 3151
Score = 166 bits (421), Expect = 4e-41
Identities = 130/441 (29%), Positives = 220/441 (49%), Gaps = 31/441 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F++ ++T + E+T + +T++ A D D N +V+ ++ + A F+++ +G
Sbjct: 3129 PVFSSDHYNT--CVYENTATKALLTRVQAVDPDIGINRKVVYSLA-DSAGGVFSIDSSSG 3185
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDH---QGVIT-RKVNIQVGDVNDNAPTFHNQPYSVRI 141
++ L QPLDRE +S + + +D Q + + V I V D+NDN P F + Y V +
Sbjct: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQ 199
PE+T GT + V AT D+G + Y + ++ F I+ G ++V LDYE +
Sbjct: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCK 3305
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ L V A D T LS +A + I +TDV D P F YS I E + G +V ++
Sbjct: 3306 RFYLVVEAKD-GGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLI 3364
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
A D D I ++IV+G+ ++ F +D + G++ + LDRE G+ L V+ +
Sbjct: 3365 AEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRER---VSGYSLLVQAVDS 3421
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE- 378
S ATV NI + D+NDN+P F + Y+ I E VG ++ L + V D+D
Sbjct: 3422 GIPAMSSTATV----NIDISDVNDNSPVFTPANYTAVIQENKPVGTSI-LQLVVTDRDSF 3476
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-V 437
+ G F + L GN F++ P + +R A+ + Y + A +S
Sbjct: 3477 HNGPPFSFSI-LSGNEEEEFVLDPHGI-------LRSAVVFQHTESLEYVLCVQAKDSGK 3528
Query: 438 PDHVGYAKVKITLINENDNRP 458
P V + +++ +I E+ ++P
Sbjct: 3529 PQQVSHTYIRVRVIEESTHKP 3549
Score = 145 bits (366), Expect = 9e-35
Identities = 119/429 (27%), Positives = 196/429 (45%), Gaps = 27/429 (6%)
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQ 121
N PL F + G F E G + + +PLD E +S + + V+D V +V I+
Sbjct: 1390 NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIK 1449
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS---QFF 178
V D NDN P F Y V I E+ T I + ATD D S S + F
Sbjct: 1450 VLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKF 1509
Query: 179 AIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
ID + G++ LD+E + L + DQ+ LA + + + D D P F N
Sbjct: 1510 RIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPY-RRNLARVIVNVEDANDHSPYFTN 1568
Query: 239 LPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGL 298
Y +++E + G+ V +TA+D+DKG + YTI +GNT ++F ++ + G++T
Sbjct: 1569 PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIIT---- 1624
Query: 299 LDRENPLYSHG-FILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 357
+ +E + + G F+L++K T+ P AT ++ + D ++ P+F +Y +
Sbjct: 1625 ICKEPDMTTMGQFVLSIKVTD--QGSPPMSATAIVRISVTMSD--NSHPKFIHKDYQAEV 1680
Query: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAI 417
E +G ++ L + ++EV G+ + F I+P S I
Sbjct: 1681 NENVDIGTSVILISAISQS------TLIYEV-KDGDINGIFTINPYSGV------ITTQK 1727
Query: 418 PLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGT 477
LDYE Y + A ++ A V I +++ENDN P+F Y+ SL E + +
Sbjct: 1728 ALDYERTSSYQLIIQAT-NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINS 1786
Query: 478 SVLTVLVSP 486
V ++ SP
Sbjct: 1787 IVRSLDNSP 1795
Score = 135 bits (339), Expect = 1e-31
Identities = 134/470 (28%), Positives = 205/470 (43%), Gaps = 45/470 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE-------EASRFFAVEPDTGVVWLRQPLD 94
+ ED PVG+ + L D D G+ G+ + + F ++ +G + L + LD
Sbjct: 945 VLEDLPVGTVIAWLETHDPD-----LGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELD 999
Query: 95 RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSV--RIPENTPVG 148
E + + + D ++ V ++V DVN+N T + ++V + EN+ +G
Sbjct: 1000 YEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG 1059
Query: 149 TPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAYQLTVN 206
T + V A D D G G + YS + S F+ID G++T LD ET +Y LTV
Sbjct: 1060 TSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVY 1119
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
ATD+ PL + + I + DV D P+ Y + E+SP +V I A D D
Sbjct: 1120 ATDRGVV-PLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSS 1178
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
+ Y I SGN + FA++ +G++T LDRE H +TV D P
Sbjct: 1179 SNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQA-EHFLEVTV------TDGGP 1231
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF-IQVVDKDENLGLNS 384
S T + V+D NDN P+F Y + + E + P++ D+DE G N+
Sbjct: 1232 SPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE--GPNA 1289
Query: 385 MFEVYLV-GNNSHHFIISPTSVQGKADIRIR-VAIPLDYETVDRYDFDLFANESVPDHVG 442
+V GN+ F I P + G R + A D T+ D P
Sbjct: 1290 EISYSIVDGNDDGKFFIDPKT--GMVSSRKQFTAGSYDILTIKAVD------NGRPQKSS 1341
Query: 443 YAKVKITLINENDNRPI---FSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
A++ I I + PI F +P YN ++ E+ V V V V P T
Sbjct: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
Score = 134 bits (337), Expect = 2e-31
Identities = 123/464 (26%), Positives = 196/464 (42%), Gaps = 33/464 (7%)
Query: 28 LPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVV 87
+P F F+ ++ED + + + + A + +++ + + + F ++ DTGV+
Sbjct: 2183 MPVFDKPFYTAS--VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVL 2240
Query: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQ--VGDVNDNAPTFHNQPYSVRIPENT 145
+ PLD E S + + SD +V + V DVNDN P F Y+ + E +
Sbjct: 2241 KVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEAS 2300
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPS----QFFAIDSARGIVTVIRELDYETTQAY 201
+GTP+ V + D D V Y + +F IDS+ G++ R LD+E Q
Sbjct: 2301 LIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHC 2360
Query: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
L V + D LS+ + I I+DV D P+F L Y + + E +P G V + A
Sbjct: 2361 TLKVRSIDSGFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQAS 2419
Query: 262 DQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL-NGLLDRENPLYSHGFILTVKGTELN 320
D D + Y+I+SGN + F +D SGV+TL N R PLYS LN
Sbjct: 2420 DADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYS-----------LN 2468
Query: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
+ T T +I V+ N +P F+ S Y + E G + I V D +
Sbjct: 2469 VSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKV---IHVRATDGDP 2525
Query: 381 GLNSMFEVYLVGN-NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVP 438
G ++ + F+I ++ LD E D +F
Sbjct: 2526 GTYGQISYAIINDFAKDRFLIDSNG-------QVITTERLDRENPLEGDVSIFVRALDGG 2578
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ V++ +++ENDN P F Y S+ +V G V V
Sbjct: 2579 GRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQV 2622
Score = 134 bits (336), Expect = 3e-31
Identities = 136/498 (27%), Positives = 213/498 (42%), Gaps = 74/498 (14%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRFFAVEPDTGVVWLRQPLDRE-- 96
+IS D PVG +T + A D+D LV +SG E FF + PD+GV+ L++ L
Sbjct: 586 VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELG-FFYLNPDSGVLQLKKSLTNSGI 644
Query: 97 TKSEFTVEFSVSDHQGVI-----------------------TR----------------- 116
F + + +D + + TR
Sbjct: 645 KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANG 704
Query: 117 KVNIQVG-----DVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS 170
K+N++ G +N P F P V + E+ PVG I + A D D G G VL++
Sbjct: 705 KLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFT 764
Query: 171 FQP--PSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITD 228
F ID G + V+ +D E T Y L + D + S+ L I + D
Sbjct: 765 ISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK-SSWRLLTINVED 823
Query: 229 VQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDY 288
D P+FI YS NI E S GT + + A D+D G + Y++++ FA++
Sbjct: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINS 881
Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
+G++ + LDRE+ + L ++ + + + V T + + D+ND +P F
Sbjct: 882 STGIVYVADQLDRES---KANYSLKIEARDKAESGQQLFSVV--TLKVFLDDVNDCSPAF 936
Query: 349 NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGK 408
S YSV + E VG + +++ D D LGL LV + + F I K
Sbjct: 937 IPSSYSVKVLEDLPVGTVI-AWLETHDPD--LGLGGQVRYSLVNDYNGRFEID------K 987
Query: 409 ADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQPL 464
A IR++ LDYE Y+ + A + V + +V++ +NEN + P F
Sbjct: 988 ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
Query: 465 YNISLYENVTVGTSVLTV 482
S+ EN +GTSVL V
Sbjct: 1048 VVGSVKENSRIGTSVLQV 1065
Score = 131 bits (330), Expect = 1e-30
Identities = 128/463 (27%), Positives = 207/463 (44%), Gaps = 41/463 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTG 85
P FT F+T LL+ T VG V ++ A D D++ L + + E + F ++ ++G
Sbjct: 1881 PVFTQAVFETILLLP--TYVGVEVLKVSATDPDSEVPPELTYSLM-EGSLDHFLIDSNSG 1937
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
V+ ++ + +K + + VSD + T V I V + D+ F YS I EN
Sbjct: 1938 VLTIKN--NNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENN 1995
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIV-TVIRELDYETTQAYQLT 204
T + IVNA L + YS P F I S G++ T D E + Y+L
Sbjct: 1996 TNITKVAIVNAVGNRLNE--PLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELV 2053
Query: 205 VNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
V A+ + D R + + I D+ D P+F+ LPY + + PGT + +TAID+
Sbjct: 2054 VEASRELDHLRVARVVVR--VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDK 2111
Query: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
DKG P G T V + F ++ SG + L + + +G + K D
Sbjct: 2112 DKG-PNG-EVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAK-----DGG 2164
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
PS ++T+ + + +N P F+ Y+ ++ E + P+ E G+
Sbjct: 2165 KPS---LSTSVELPITIVNKAMPVFDKPFYTASVNE--DIRMNTPILSINATSPEGQGI- 2218
Query: 384 SMFEVYLV--GNNSHHFIIS-PTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
+Y++ G+ F I T V ++V PLDYE Y + A++++
Sbjct: 2219 ----IYIIIDGDPFKQFNIDFDTGV-------LKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V + + + NDN PIF QP YN +L E +GT VL V+
Sbjct: 2268 RAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVV 2310
Score = 130 bits (326), Expect = 4e-30
Identities = 117/471 (24%), Positives = 200/471 (42%), Gaps = 47/471 (9%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P+FTN ++ + E +GS+V Q+ A D D N L++ + F +EP G
Sbjct: 1564 PYFTNPLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLG 1621
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQG----VITRKVNIQVGDVNDNAPTFHNQPYSVRI 141
++ + + D T +F + V+D QG T V I V +++ P F ++ Y +
Sbjct: 1622 IITICKEPDMTTMGQFVLSIKVTD-QGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEV 1680
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQ 199
EN +GT + +++A + +++Y + + F I+ G++T + LDYE T
Sbjct: 1681 NENVDIGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTS 1735
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR--- 256
+YQL + AT+ +++ A + I I D D P+F+ YS ++ E +P + VR
Sbjct: 1736 SYQLIIQATNM---AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLD 1792
Query: 257 ----IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFIL 312
+I A D D R + Y IV F +D +G + LD E + H +
Sbjct: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHV- 1851
Query: 313 TVKGTELNDDRTPS-DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
+ D +P A NI V D+NDN P F + + + VG + L +
Sbjct: 1852 -----HVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV-LKV 1905
Query: 372 QVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL 431
D D + + L+ + HF+I S + + + + + L
Sbjct: 1906 SATDPDSEVPPELTYS--LMEGSLDHFLIDSNS----------GVLTIKNNNLSKDHYML 1953
Query: 432 FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
S + V I + D+ F+Q Y+ S+ EN T T V V
Sbjct: 1954 IVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIV 2004
Score = 129 bits (323), Expect = 9e-30
Identities = 123/485 (25%), Positives = 213/485 (43%), Gaps = 60/485 (12%)
Query: 42 ISEDTPVGS--SVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
ISE +P G ++ +L + +D + + +S E + +F + P +G++ +PL+ K
Sbjct: 385 ISEFSPPGVVVAIVKLSPEPIDVE---YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKE 441
Query: 100 EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
+ +E V++ +G + +V I + D ND+ P F Y + E+ PVGT + V+A+D
Sbjct: 442 VYKLE--VTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDK 499
Query: 160 DLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETT-QAYQLTVNATDQDKTRPLS 217
D G G + YS + F I+ G+++ ELD+E++ + Y+ V A+D
Sbjct: 500 DKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHE 559
Query: 218 TLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVS 277
+ N+ I I +V D P+F + I P G + ++AID D+ + Y I+S
Sbjct: 560 SEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIIS 617
Query: 278 GNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF--- 334
GN F L+ SGVL L L + + F L + T+ + P ++
Sbjct: 618 GNELGFFYLNPDSGVLQLKKSLTNSG-IKNGNFALRITATDGENLADPMSINISVLHGKV 676
Query: 335 ------------------NILV-----------------IDINDNAPEFNSSEYS-VAIT 358
+L+ IN P F+ S S VA+
Sbjct: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
Query: 359 ELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIP 418
E VG A L I+ D D +F + GN F I + Q ++V +P
Sbjct: 737 EDLPVG-ANILKIKAYDADSGFNGKVLFTI-SDGNTDSCFNIDMETGQ------LKVLMP 788
Query: 419 LDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGT 477
+D E D Y ++ + P + + I + + NDN P+F Q Y++++ E+ +GT
Sbjct: 789 MDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
Query: 478 SVLTV 482
++ V
Sbjct: 849 EIIQV 853
Score = 122 bits (307), Expect = 6e-28
Identities = 121/461 (26%), Positives = 205/461 (44%), Gaps = 40/461 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E++ +G+SV Q+ A+D D+ + + + F+++ ++GV+ LDRET
Sbjct: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM 1111
Query: 99 SEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+ + +D +GV+ T +V I+V DVNDNAP Y + EN+P + +
Sbjct: 1112 GSYWLTVYATD-RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Query: 155 NATDPDLGAGGSVLYSFQP--PSQFFAIDSARGIVTVI-RELDYETTQAYQLTVNATDQD 211
A DPD + + Y P FFAI+ G++T R+LD E + L V TD
Sbjct: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
Query: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP--GTTVRIITAIDQDKGRPR 269
+ ST+ + + + D D P F Y + E G + A D+D+G
Sbjct: 1231 PSPKQSTIW-VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNA 1289
Query: 270 GIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDAT 329
I Y+IV GN + F +D +G+++ R+ ILT+K D+ P ++
Sbjct: 1290 EISYSIVDGNDDGKFFIDPKTGMVS-----SRKQFTAGSYDILTIKAV---DNGRPQKSS 1341
Query: 330 VTTTFNILVIDINDNAP---EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T +I I +P F+ Y+ + E +V ++V N+
Sbjct: 1342 -TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-------TEIVGVVSVQPANTPL 1393
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKV 446
+VG N + V I +A PLD E Y+ + + +V +V
Sbjct: 1394 WFDIVGGNFDSAFDAEKGVG-----TIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQV 1446
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
I +++ NDN P FSQP Y++++ E+V T +L + + R
Sbjct: 1447 FIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDR 1487
Score = 121 bits (304), Expect = 1e-27
Identities = 130/460 (28%), Positives = 205/460 (44%), Gaps = 48/460 (10%)
Query: 42 ISEDTPVGSSVTQL-------LAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQ 91
+SE P+ S V L A D D N LV+ + A +FF V+ TG +
Sbjct: 1778 LSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIA 1837
Query: 92 PLDRETKSEFTVEFSVSDHQGVITR-----KVNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
LD ET + F V D +VNI+V DVNDN P F + + T
Sbjct: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTV 205
VG + V+ATDPD + YS S F IDS G++T+ + + + Y L V
Sbjct: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTI--KNNNLSKDHYMLIV 1955
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
+D + + + I++ + D F YST+I E++ T V I+ A+
Sbjct: 1956 KVSD----GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL 2011
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGL-LDR-ENPLYSHGFILTVKGTELNDDR 323
P + Y+I+ N + F + SGV+ G+ DR E LY ++ EL+ R
Sbjct: 2012 NEP--LKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYE---LVVEASRELDHLR 2064
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
A V NI DINDN+P F Y A+ A+ G L QV D++ G N
Sbjct: 2065 V---ARVVVRVNI--EDINDNSPVFVGLPYYAAVQVDAEPG---TLIYQVTAIDKDKGPN 2116
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVG 442
Y++ ++ HF I+P S ++ ++ A D ++ Y + A + P
Sbjct: 2117 GEV-TYVLQDDYGHFEINPNS----GNVILKEAFNSDLSNIE-YGVTILAKDGGKPSLST 2170
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
++ IT++N+ P+F +P Y S+ E++ + T +L++
Sbjct: 2171 SVELPITIVNK--AMPVFDKPFYTASVNEDIRMNTPILSI 2208
Score = 121 bits (303), Expect = 2e-27
Identities = 126/464 (27%), Positives = 202/464 (43%), Gaps = 35/464 (7%)
Query: 31 FTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR 90
FT F+ T + + ++ + + N+PL + + F ++ +GV+
Sbjct: 1982 FTQSFYSTSISENNTNITKVAIVNAVGNRL-NEPLKYSILNP--GNKFKIKSTSGVIQTT 2038
Query: 91 Q-PLDRETKS--EFTVEFSVS-DHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
P DRE + E VE S DH V V + + D+NDN+P F PY + +
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTV 205
GT I+ V A D D G G V Y Q F I+ G V + + + + Y +T+
Sbjct: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTI 2158
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A D K LST L I I V P+F Y+ ++ E T + I A +
Sbjct: 2159 LAKDGGKPS-LSTSVELPITI--VNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEG 2215
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
+GI Y I+ G+ F +D+ +GVL + LD E + + LT++ ++
Sbjct: 2216 ---QGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYE---VTSAYKLTIRASD-----AL 2264
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ A T ++LV D+NDN P F+ Y+ ++E + +G + +QVV D + N M
Sbjct: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPV---LQVVSIDADSENNKM 2321
Query: 386 FEVYLVG---NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
+V N++ +F I +S I A LD+E V + + +S P
Sbjct: 2322 VHYQIVQDTYNSTDYFHIDSSSGL------ILTARMLDHELVQHCTLKVRSIDSGFPSLS 2375
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
V I + + NDN P+F+Q +Y + E G V V S
Sbjct: 2376 SEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQAS 2419
Score = 108 bits (269), Expect = 2e-23
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 46/412 (11%)
Query: 93 LDRETKSEFT--VEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
L+RE + + V+ SV KVNIQV D+ND P F YSV I E+TP+ T
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
+ V ATD D+G+ G Y F+ F++ G++++ L+Y+ Y L + A D+
Sbjct: 177 VAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236
Query: 211 DK----TRPLSTLANLAIIITDVQDMDP---IFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
+S+ A L + I + + P + ++P+S E P T ++T D
Sbjct: 237 GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS---LEKEP---TYAVVTVDDL 290
Query: 264 DKGRPRGI-GYTIVSGNTNSIFALDYISGVLTLNGLLDREN---PLYSHGFILTVKGTEL 319
D G I +IV+G+ F L L + +R+ + +G+ LT++ +
Sbjct: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFA---LPLFIQVVD 375
+ S N D P F Y V+I+E + G + L + +D
Sbjct: 351 GSPQKCSALKAVYIGN----PTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID 406
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
+ L G ++ +F I+P S I A PL+ + Y ++ E
Sbjct: 407 VEYKLS---------PGEDAVYFKINPRSG------LIVTARPLNTVKKEVYKLEVTNKE 451
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
A+V I++ + ND+ P F QPLY+ + E+V VGTSVLTV S +
Sbjct: 452 GDLK----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDK 499
Score = 107 bits (267), Expect = 3e-23
Identities = 116/466 (24%), Positives = 193/466 (41%), Gaps = 33/466 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTG 85
P F +++Y +SE P G VT + A D D+ D L + + F ++ +G
Sbjct: 2392 PVFNQLIYESY--VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
V+ L + + +++ SVSD T +V+I+V N +P F Y + EN
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENV 2509
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQL 203
GT + V ATD D G G + Y+ F IDS ++T R LD E +
Sbjct: 2510 AAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTER-LDRENPLEGDV 2568
Query: 204 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
++ D +T + +I+ D D P F+ + Y ++ G V + AID
Sbjct: 2569 SIFVRALD-GGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDP 2627
Query: 264 DKGRPRGIGYTIVSGNTNSI---FALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELN 320
D G I Y++ S + S+ +D +G + G ++ F+ V
Sbjct: 2628 DDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV------ 2681
Query: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
D P ++ + I V+ P F S+YS I E +G + + +N+
Sbjct: 2682 DGGIPVKHSLIPVY-IHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTL--RILPSQNV 2738
Query: 381 GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVP-- 438
+++ N F+I + K D R LD ET + F + A ++P
Sbjct: 2739 WFSTVNGERPENNKGGIFVIEQETGTIKLDKR------LDRETSPAFHFKVAA--TIPLD 2790
Query: 439 --DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
D V V I +++ NDN+P+F Y+ + E + VGT + V
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQV 2836
Score = 97.8 bits (242), Expect = 2e-20
Identities = 117/449 (26%), Positives = 187/449 (41%), Gaps = 63/449 (14%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF------FAVEPDTGVVWLRQPLDR 95
I+E TP+ +SV Q+ A D D G +GE F F+V P +GV+ L L+
Sbjct: 167 IAESTPLRTSVAQVTATDAD-----IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNY 221
Query: 96 ETKSEFTVEFSVSD-------HQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ K+ + +E D + GV T K+ + + +N++APT H +P +
Sbjct: 222 DEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIH---VVTHVPFSLEK 278
Query: 148 GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYET-T 198
+V D D GA G + + + P QFF + + + +++D+E+
Sbjct: 279 EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFP 338
Query: 199 QAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI-FINLPYSTNIYEHSPPGTTVRI 257
Y LT+ A D+ + S L I +D PI F Y +I E SPPG V I
Sbjct: 339 YGYNLTLQAKDKGSPQKCSAL-KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAI 397
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ + P + Y + G F ++ SG++ L+ TVK
Sbjct: 398 VKLSPE----PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLN------------TVKKE 441
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
+ T + + I + D ND+ PEF Y + E VG ++ L + DKD
Sbjct: 442 VYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV-LTVSASDKD 500
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISP-TSVQGKADIRIRVAIPLDYE-TVDRYDFDLFANE 435
+ G N + N F+I+ T V I LD+E + + Y F + A++
Sbjct: 501 K--GENGYITYSIASLNLLPFVINQFTGV-------ISTTEELDFESSPEIYRFIVRASD 551
Query: 436 --SVPDHVGYAKVKITLINENDNRPIFSQ 462
S H V I + N NDN P+F +
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
Score = 93.6 bits (231), Expect = 4e-19
Identities = 119/477 (24%), Positives = 183/477 (38%), Gaps = 55/477 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVE----PDTGVVWLRQPLDRET 97
+ E+ G+ V + A D DP +G FA + G V + LDRE
Sbjct: 2505 VRENVAAGTKVIHVRATD--GDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDREN 2562
Query: 98 KSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
E V V G V + V D NDNAP F Y + + G + V
Sbjct: 2563 PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQV 2622
Query: 155 NATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
A DPD GA + YS + V+V L+ + + +T +Q K
Sbjct: 2623 QAIDPDDGANSRITYSLYSEAS----------VSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
Query: 215 PLS--------------TLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITA 260
LS +L + I + + P F YS I E + G+TV +
Sbjct: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
Query: 261 IDQDKGRPRGIGYTIVSG-----NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
+ + + ++ V+G N IF ++ +G + L+ LDRE S F V
Sbjct: 2733 LPS-----QNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRET---SPAFHFKVA 2784
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375
T D D T +I V+D+NDN P F +S Y I E VG L QV
Sbjct: 2785 ATIPLDK---VDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT---QVRA 2838
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
D + G N L ++ ++ ++ I LD+ET + F + A++
Sbjct: 2839 IDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGW-ISTLKDLDHETDPTFTFSVVASD 2897
Query: 436 --SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTA 490
A V + + + NDN P+F+Q +Y ++ E+ G V + R T+
Sbjct: 2898 LGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTS 2954
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 187 bits (476), Expect = 2e-47
Identities = 147/482 (30%), Positives = 233/482 (48%), Gaps = 38/482 (7%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASR---FFA 79
NR P F + + T L+ E+ G++V +++AQD D LV+ ++ SR F+
Sbjct: 320 NRHPQFPQYNYQT--LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQP 136
++P +G++ LDRE+ + + DH T V + V D ND++P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP-------SQFFAIDSARGIVTV 189
Y + EN G PI + ATD D ++ Y F P + F ID G+++
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 190 IRELDYETTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
+D E ++Y+L V A+DQ + P S + I + D D P F Y + E
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 249 SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSH 308
P T V +TA D+DK + Y I+SGN+ FA+D ++G + + LD E
Sbjct: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA---ER 614
Query: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP 368
+ L ++ D P + T +I V+DIND+ P F S+ + V++ E A +G ++
Sbjct: 615 EYALRIRA---QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV- 670
Query: 369 LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDR 426
+ IQ VD D G N+ E L G ++P + V A + V+ PLD E+V+
Sbjct: 671 IHIQAVDADH--GENARLEYSLTG-------VAPDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 427 YDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
Y F + A + P A V +T+++ NDNRP F+ Y++ L E+ VGTSV++V
Sbjct: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 486 PR 487
R
Sbjct: 782 DR 783
Score = 180 bits (456), Expect = 3e-45
Identities = 143/465 (30%), Positives = 234/465 (50%), Gaps = 44/465 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRF-----FAVEPDTGVVWLRQPL 93
+ E+ G + QL A D D P L + G A+R F ++P +G++ +
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
Query: 94 DRETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
DRE + + SD QG T +V+I V D NDNAP F + Y ++ E+
Sbjct: 502 DREHMESYELVVEASD-QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560
Query: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTV 205
T + V ATD D A G V Y+ + FAIDS G + V+ LD+E + Y L +
Sbjct: 561 HTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRI 620
Query: 206 NATDQDKTRPLSTLANLAII-ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
A D + PLS LA I + D+ D PIF++ P+ ++ E++P G +V I A+D D
Sbjct: 621 RAQDAGRP-PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
G + Y++ ++ F ++ +G ++++G LDRE+ H F G E D +
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRES--VEHYFF----GVEARDHGS 733
Query: 325 P---SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
P + A+VT T V+D+NDN PEF EY + + E A VG ++ + + VD+D N
Sbjct: 734 PPLSASASVTVT----VLDVNDNRPEFTMKEYHLRLNEDAAVGTSV-VSVTAVDRDANSA 788
Query: 382 LNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDH 440
++ GN + F I S QG + + +A+PLDY+ + L A++ ++ DH
Sbjct: 789 ISYQI---TGGNTRNRFAI---STQGGVGL-VTLALPLDYKQERYFKLVLTASDRALHDH 841
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
V I + + N +RP+F Y++S+ E+ +G++++ + S
Sbjct: 842 ---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISAS 883
Score = 162 bits (409), Expect = 9e-40
Identities = 124/434 (28%), Positives = 208/434 (47%), Gaps = 24/434 (5%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGV--VWLRQPLDR 95
+L ++ED VG+SV + A D D N + + ++G FA+ GV V L PLD
Sbjct: 762 HLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDY 821
Query: 96 ETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
+ + F + + SD V+I + D N + P F + YSV + E+ P+G+ I +++
Sbjct: 822 KQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 881
Query: 156 ATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
A+D D+G + Y + F ID+ G +T+ LDYE Y L + A D +
Sbjct: 882 ASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK 941
Query: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
T + +++ DV D P F+ Y+ + E +PP T+V I+A D+D + YT
Sbjct: 942 ADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF 1000
Query: 276 VSG-NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
+G + + F ++ SG++ LDRE + + T DR +
Sbjct: 1001 QNGEDGDGDFTIEPTSGIVRTVRRLDRE-------AVSVYELTAYAVDRGVPPLRTPVSI 1053
Query: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
++V D+NDNAP F + E+ V + E + VG ++ I VD DE + M+++ + GN
Sbjct: 1054 QVMVQDVNDNAPVFPAEEFEVRVKENSIVG-SVVAQITAVDPDEGPNAHIMYQI-VEGNI 1111
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEN 454
F + S + + I LDYE R ++ + + V A V + L+++N
Sbjct: 1112 PELFQMDIFSGE------LTALIDLDYEA--RQEYVIVVQATSAPLVSRATVHVRLVDQN 1163
Query: 455 DNRPIFS--QPLYN 466
DN P+ + Q L+N
Sbjct: 1164 DNSPVLNNFQILFN 1177
Score = 160 bits (406), Expect = 2e-39
Identities = 135/466 (28%), Positives = 213/466 (45%), Gaps = 31/466 (6%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEP 82
+ +P F + F +L E+ P+G SV + A D D N L + ++G F +
Sbjct: 646 DHIPIFVSTPFQVSVL--ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINS 703
Query: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSV 139
TG V + PLDRE+ + DH + V + V DVNDN P F + Y +
Sbjct: 704 ATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHL 763
Query: 140 RIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGI--VTVIRELDYET 197
R+ E+ VGT + V A D D + S + FAI + G+ VT+ LDY+
Sbjct: 764 RLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQ 823
Query: 198 TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
+ ++L + A+D R L + I ITD P+F + YS ++ E P G+T+ +
Sbjct: 824 ERYFKLVLTASD----RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVV 879
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
I+A D D G I Y + F +D SG +TL LD E+ + ++ +T +
Sbjct: 880 ISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQV-TYTLAITAR-- 934
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
D+ P A TT ++V D+NDNAP+F +S Y+ ++E A F L I D+D
Sbjct: 935 ---DNGIPQKAD-TTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP-FTSVLQISATDRD 989
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NES 436
+ + + F I PTS +R LD E V Y+ +A +
Sbjct: 990 AHANGRVQYTFQNGEDGDGDFTIEPTSGI------VRTVRRLDREAVSVYELTAYAVDRG 1043
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
VP +++ + + NDN P+F + + + EN VG+ V +
Sbjct: 1044 VPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQI 1089
Score = 154 bits (388), Expect = 3e-37
Identities = 132/458 (28%), Positives = 206/458 (44%), Gaps = 35/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ ED + V ++ A D D D + + + + FA++ TG + + PLD E +
Sbjct: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
Query: 99 SEFTVEFSVSDHQ----GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
E+ + D T +IQV D+ND+ P F + P+ V + EN P+G + +
Sbjct: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Query: 155 NATDPDLGAGGSVLYSFQ--PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
A D D G + YS P F I+SA G V+V LD E+ + Y V A D
Sbjct: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
PLS A++ + + DV D P F Y + E + GT+V +TA+D+D I
Sbjct: 734 P-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANS--AIS 790
Query: 273 YTIVSGNTNSIFALDYISGV--LTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
Y I GNT + FA+ GV +TL LD + Y +LT L+D
Sbjct: 791 YQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFK-LVLTASDRALHDH-------- 841
Query: 331 TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
+I + D N + P F S+ YSV++ E +G + + + D+++G N+ YL
Sbjct: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTI---VVISASDDDVGENARI-TYL 896
Query: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKIT 449
+ +N F I S I + PLDYE Y + A ++ +P V++
Sbjct: 897 LEDNLPQFRIDADSGA------ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVM 950
Query: 450 LINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
+ + NDN P F Y + E+ TSVL + + R
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDR 988
Score = 114 bits (286), Expect = 2e-25
Identities = 91/305 (29%), Positives = 140/305 (45%), Gaps = 24/305 (7%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVE 81
N F +H+ L+SED P +SV Q+ A D D N + + +GE+ F +E
Sbjct: 957 NAPQFVASHYTG---LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013
Query: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS 138
P +G+V + LDRE S + + D R + + V DVNDNAP F + +
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFE 1073
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYE 196
VR+ EN+ VG+ + + A DPD G ++Y + + F +D G +T + +LDYE
Sbjct: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133
Query: 197 TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-----YSTNIYEHSPP 251
Q Y + V AT + PL + A + + + D D P+ N Y +N + P
Sbjct: 1134 ARQEYVIVVQAT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPS 1189
Query: 252 GTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI 311
G RI A D D + Y+ GN + ++ SG L L+ LD PL + +
Sbjct: 1190 GIIGRI-PAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLV 1246
Query: 312 LTVKG 316
G
Sbjct: 1247 TVTDG 1251
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 182 bits (461), Expect = 9e-46
Identities = 136/444 (30%), Positives = 214/444 (48%), Gaps = 25/444 (5%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTG-- 85
P FT ++ L ++ED VGSSV L A+D D N + + ++G FA+ G
Sbjct: 685 PVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
++ L PLD + + ++ + + SD T V I V D N + P F + Y+V + E+
Sbjct: 743 LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTV 205
PVGT I ++A D D G + Y Q P F ID G + + ELDYE AY LT+
Sbjct: 803 PVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTI 862
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A D + T L I+I D D P F+ Y +I+E +PP T++ ++A D+D
Sbjct: 863 MAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
Query: 266 GRPRGIGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
G + YT G+ + F ++ SGV+ LDREN + + L V D +
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAV------DRGS 975
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
P+ + + + ++DINDNAP F E + + E VG ++ I+ D DE
Sbjct: 976 PTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG-SVVAKIRANDPDEGPNAQI 1034
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYA 444
M+++ + G+ H F + + +R + LD+E R ++ L + V A
Sbjct: 1035 MYQI-VEGDMRHFFQLDLLNGD------LRAMVELDFEV--RREYVLVVQATSAPLVSRA 1085
Query: 445 KVKITLINENDNRPIFS--QPLYN 466
V I L+++NDN P+ Q L+N
Sbjct: 1086 TVHILLVDQNDNPPVLPDFQILFN 1109
Score = 179 bits (453), Expect = 7e-45
Identities = 143/471 (30%), Positives = 227/471 (48%), Gaps = 51/471 (10%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E+ VG V + A D D N L + V G A F + +GVV R LDRE
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA 420
Query: 99 SEFTVEFSVSDHQG------VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
+E+ + +D QG T V I+V D NDN P F Q Y V++PE+ + T +
Sbjct: 421 AEYQLLVEAND-QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
Query: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
V ATD D G ++ YS QF+ + S GI+ VI LD+E Q Y L++ A D
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
+ +++ +++ + DV D +PIF++ P+ + E+ P G V I A+D D G
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 270 GIGYTIVSGNTNSI-----------------FALDYISGVLTLNGLLDRENPLYSHGFIL 312
+ Y +V + + F + SG +T+ LDRE + + F
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF-- 655
Query: 313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
G E D +P ++ +T+ +I V+D+NDN P F Y + + E A VG ++ L +Q
Sbjct: 656 ---GVEAVDHGSPPMSS-STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV-LTLQ 710
Query: 373 VVDKDENLGLNSMFEVYLVGNNS-HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL 431
D+D NS+ L G N+ + F +S G I +A+PLDY+ +Y +
Sbjct: 711 ARDRD----ANSVITYQLTGGNTRNRFALSSQRGGG----LITLALPLDYKQEQQYVLAV 762
Query: 432 FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
A++ H + + +T + N +RP+F Y +S+ E+ VGTS+ T+
Sbjct: 763 TASDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATL 811
Score = 168 bits (426), Expect = 1e-41
Identities = 139/468 (29%), Positives = 212/468 (45%), Gaps = 33/468 (7%)
Query: 44 EDTPVGSSVTQLLAQ---DMDNDPLVFGVSG--EEASR-FFAVEPDTGVVWLRQPLDRET 97
E+ P G+ + QL A + + + + + + G +E SR +F ++ TG V LDRET
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 98 KSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
K + D+ T + + V D ND++P F Y R+ EN VG + +
Sbjct: 316 KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
Query: 155 NATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
A+D D ++ Y + F ++ + G+V+ LD E YQL V A DQ +
Sbjct: 376 RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435
Query: 214 R-PLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
PLS A + I + D D P F Y + E T V + A D+D+G+ I
Sbjct: 436 PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y+I+SGN F L +SG+L + LD E+ + L++K D P +
Sbjct: 496 YSILSGNVAGQFYLHSLSGILDVINPLDFEDV---QKYSLSIKA---QDGGRPPLINSSG 549
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
++ V+D+NDN P F SS + + E +G+ + + IQ VD D G N+ LV
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-VHIQAVDADS--GENARLHYRLVD 606
Query: 393 NNSHHF---IISPTSVQGKADIR---------IRVAIPLDYETVDRYDFDLFA-NESVPD 439
S P + D I V LD E V+ Y F + A + P
Sbjct: 607 TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPP 666
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPR 487
V IT+++ NDN P+F+QP Y + L E+ VG+SVLT+ R
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
Score = 152 bits (384), Expect = 7e-37
Identities = 136/488 (27%), Positives = 219/488 (44%), Gaps = 69/488 (14%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVEPDTGVVWLRQPLDRET 97
+ ED + ++V ++ A D D N + + + SG A +F+ + +G++ + PLD E
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFED 526
Query: 98 KSEFTVEFSVSD--------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
++++ D GV V++QV DVNDN P F + P+ + EN P+G
Sbjct: 527 VQKYSLSIKAQDGGRPPLINSSGV----VSVQVLDVNDNEPIFVSSPFQATVLENVPLGY 582
Query: 150 PIFIVNATDPDLGAGGSVLYSF------------------QPPSQF-FAIDSARGIVTVI 190
P+ + A D D G + Y P F F I ++ G +TV
Sbjct: 583 PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC 642
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
ELD E + Y V A D P+S+ +++I + DV D DP+F Y + E +
Sbjct: 643 AELDREEVEHYSFGVEAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAA 701
Query: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL---YS 307
G++V + A D+D I Y + GNT + FAL G GL+ PL
Sbjct: 702 VGSSVLTLQARDRDANSV--ITYQLTGGNTRNRFALSSQRG----GGLITLALPLDYKQE 755
Query: 308 HGFILTVKGTELNDDRTPSDATVTTTFNIL--VIDINDNAPEFNSSEYSVAITELAQVGF 365
++L V T SD T + T ++L V D N + P F SS Y+V+++E VG
Sbjct: 756 QQYVLAV---------TASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
Query: 366 ALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVD 425
++ DE+ G N+ Y++ + F I P S + + LDYE
Sbjct: 807 SIATLSA---NDEDTGENARI-TYVIQDPVPQFRIDPDSGT------MYTMMELDYENQV 856
Query: 426 RYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLV 484
Y + A ++ +P ++I +++ NDN P F Y S++E+ TS+L V
Sbjct: 857 AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSA 916
Query: 485 SPRFTAGP 492
+ R +GP
Sbjct: 917 TDR-DSGP 923
Score = 134 bits (336), Expect = 3e-31
Identities = 131/482 (27%), Positives = 211/482 (43%), Gaps = 51/482 (10%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRF-------- 77
P F + F +L E+ P+G V + A D D N L + + + AS F
Sbjct: 563 PIFVSSPFQATVL--ENVPLGYPVVHIQAVDADSGENARLHYRLV-DTASTFLGGGSAGP 619
Query: 78 ----------FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGD 124
F + +G + + LDRE ++ DH + V+I V D
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLD 679
Query: 125 VNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSAR 184
VNDN P F Y +R+ E+ VG+ + + A D D + + + FA+ S R
Sbjct: 680 VNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQR 739
Query: 185 G--IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
G ++T+ LDY+ Q Y L V A+D ++ L N +TD P+F + Y+
Sbjct: 740 GGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLIN----VTDANTHRPVFQSSHYT 795
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302
++ E P GT++ ++A D+D G I Y I F +D SG + LD E
Sbjct: 796 VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE 853
Query: 303 NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQ 362
N + + LT+ D+ P + TTT IL++D NDNAP+F Y +I E A
Sbjct: 854 NQV---AYTLTIMA---QDNGIPQKSD-TTTLEILILDANDNAPQFLWDFYQGSIFEDAP 906
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
++ L + D+D ++ + F I PTS IR LD E
Sbjct: 907 PSTSI-LQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV------IRTQRRLDRE 959
Query: 423 TVDRYD-FDLFANESVPDHVGYA-KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
V Y+ + L + P + + ++++T+++ NDN P+F + + + EN VG+ V
Sbjct: 960 NVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVA 1019
Query: 481 TV 482
+
Sbjct: 1020 KI 1021
Score = 116 bits (290), Expect = 6e-26
Identities = 93/315 (29%), Positives = 140/315 (44%), Gaps = 32/315 (10%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP----LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
I ED P +S+ Q+ A D D+ P L G++ F +EP +GV+ ++ LDRE
Sbjct: 901 IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN 960
Query: 98 KSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153
+ + + D ++ V IQV D+NDNAP F + + EN PVG+ +
Sbjct: 961 VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK 1020
Query: 154 VNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
+ A DPD G ++Y FF +D G + + ELD+E + Y L V AT
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT--- 1077
Query: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIY----EHSPPGTTVRIITAIDQDKGR 267
+ PL + A + I++ D D P+ + N Y +S P + I A D D
Sbjct: 1078 -SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSD 1136
Query: 268 PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL------------YSHGFILTVK 315
+ YT V GN + LD +G L L+ LD PL +S T++
Sbjct: 1137 --SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLR 1194
Query: 316 GTELNDDRTPSDATV 330
T + DD + TV
Sbjct: 1195 VTIITDDMLTNSITV 1209
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 168 bits (425), Expect = 1e-41
Identities = 135/427 (31%), Positives = 196/427 (45%), Gaps = 28/427 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASR---FFAVEPDTGVVWLRQPLDRETK 98
+ ED P G + ++A+D D VS AS F + TG + + +PLDRE +
Sbjct: 1554 LPEDQPPGPAALHVVARDPDLGEAA-RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQR 1612
Query: 99 SEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
+E + SDH T+ + + V DVND APTF Q YSV + EN P GT + +
Sbjct: 1613 AEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLR 1672
Query: 156 ATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
ATDPD+GA G V Y S+ F++D G++T +R LD E + LTV A D+ + P
Sbjct: 1673 ATDPDVGANGQVTYG-GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRG-SPP 1730
Query: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
T + + + D D P F + S + E P T+ ++ A D D G + Y I
Sbjct: 1731 QLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRI 1789
Query: 276 VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFN 335
+ G+ + F LD SG LDRE F L + E D P+ + T
Sbjct: 1790 LDGDPSGAFVLDLASGEFGTMRPLDRE---VEPAFQLRI---EARDGGQPA-LSATLLLT 1842
Query: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
+ V+D ND+AP F YSV + E G L +Q+ D + G N YL +
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAG---TLLLQLQAHDPDAGANGHVTYYLGAGTA 1899
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINE 453
F++ P+S + +R A LD E Y F + A + V IT+ +
Sbjct: 1900 GAFLLEPSSGE------LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
Query: 454 NDNRPIF 460
ND+ P F
Sbjct: 1954 NDHAPTF 1960
Score = 149 bits (377), Expect = 5e-36
Identities = 138/464 (29%), Positives = 205/464 (44%), Gaps = 39/464 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF-FAVEPDTGVVWLRQPLDRETK 98
L +SED +GS + Q+ D+D+ P+++ V + F+V G V L PLD E
Sbjct: 2283 LRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQC 2342
Query: 99 SEFTVEFSVSD--HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
+ ++ D H+G + + V DVNDNAP F Y V + E+TP G+ I V+A
Sbjct: 2343 DRYQLQLLAHDGPHEG--RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA 2400
Query: 157 TDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVI---RELDYETTQAYQLTVNATDQDKT 213
TD D GA G + Y P+ F++D G + I L ++ + A + + A D
Sbjct: 2401 TDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHG-A 2459
Query: 214 RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR-GIG 272
+ A + + + D D P F Y + E PPG+T+ + A D D R +
Sbjct: 2460 PGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVD 2519
Query: 273 YTIVSGNTNSIFALD--------------YISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
Y+I+SGN +F L+ G L L LD E+ + LTV +
Sbjct: 2520 YSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ---YNLTVAAAD 2576
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
S VT T V+D+NDN P F + Y V + E VG L L ++ D D
Sbjct: 2577 RGQPPQSSVVPVTVT----VLDVNDNPPVFTRASYRVTVPEDTPVGAEL-LHVEASDADP 2631
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVP 438
F V G+ S F + +S +R+A LD ET R+ + A +
Sbjct: 2632 GPHGLVRFTV-SSGDPSGLFELDESSG------TLRLAHALDCETQARHQLVVQAADPAG 2684
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
H A V I + + ND+ P F L + S+ EN GT V T+
Sbjct: 2685 AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTL 2728
Score = 148 bits (373), Expect = 1e-35
Identities = 131/474 (27%), Positives = 216/474 (45%), Gaps = 37/474 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRET 97
+ E P+ + Q+ A D+D + + ++ + +R F V+P TG + LDRE
Sbjct: 2180 LPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREI 2239
Query: 98 KSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+E + +D V + + + V D NDN PT QP+ +R+ E+ +G+ I V
Sbjct: 2240 WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQV 2298
Query: 155 NATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
D D G + S P F++ G V++ LD+E YQL + A D
Sbjct: 2299 TGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---- 2354
Query: 215 PLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT 274
P ANL +++ DV D P F Y + EH+PPG+ + ++A D+D G I Y
Sbjct: 2355 PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYH 2414
Query: 275 IVSGNTNSIFALDYISGVL-TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 333
+ S F++D +G L T+ G + + G + V E D P A T
Sbjct: 2415 LASPADG--FSVDPNNGTLFTIVGTVALGHD--GSGAVDVV--LEARDHGAPGRAA-RAT 2467
Query: 334 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGN 393
++ + D ND+AP F S Y VA+TE G L L ++ D D + ++ + GN
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTL-LTLEATDADGSRSHAAVDYSIISGN 2526
Query: 394 NSHHFIISPTSVQ-------GKADIRIRVAI-PLDYETVDRYDFDLFA-NESVPDHVGYA 444
F + P + G + V + PLD+E++ +Y+ + A + P
Sbjct: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTAGPLSSPGP 498
V +T+++ NDN P+F++ Y +++ E+ VG +L V S + PGP
Sbjct: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASD-------ADPGP 2633
Score = 139 bits (351), Expect = 5e-33
Identities = 131/459 (28%), Positives = 196/459 (42%), Gaps = 44/459 (9%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPD---------TGVVWLR 90
L + E+ G+++ A D D G + + R EP TG +
Sbjct: 1443 LALPENPEPGAALYTFRASDADGP----GPNSDVRYRLLRQEPPVPALRLDARTGALSAP 1498
Query: 91 QPLDRETKSEFTVEFSVSDHQGVITRK------VNIQVGDVNDNAPTFHNQPYSVRIPEN 144
+ LDRET + +D +R+ + V D NDNAP F + P VR+PE+
Sbjct: 1499 RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPED 1557
Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQL 203
P G V A DPDLG V Y F + S+ G ++V+R LD E + L
Sbjct: 1558 QPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVL 1617
Query: 204 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
TV A+D P S L + + DV D P F YS + E++PPGT++ + A D
Sbjct: 1618 TVVASDHGSP-PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDP 1676
Query: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
D G + Y VS + F+LD +GVLT LDRE LTV DR
Sbjct: 1677 DVGANGQVTYGGVSSES---FSLDPDTGVLTTLRALDREE---QEEINLTVYA----QDR 1726
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
T + V D ND+AP F S+ S+ + E G + D ++G N
Sbjct: 1727 GSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE----GQDPQTLTMLRASDPDVGAN 1782
Query: 384 SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
+ ++ G+ S F++ S + PLD E + + A + P
Sbjct: 1783 GQLQYRILDGDPSGAFVLDLASGE------FGTMRPLDREVEPAFQLRIEARDGGQPALS 1836
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
+ +T+++ ND+ P F P Y++ + E+V GT +L
Sbjct: 1837 ATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
Score = 135 bits (341), Expect = 7e-32
Identities = 129/466 (27%), Positives = 199/466 (42%), Gaps = 38/466 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLV---FGVSGEEASRFFAVEPDTGVVWLRQP---- 92
L + E T G+ A+D D L + +SG+ A F +E G P
Sbjct: 150 LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209
Query: 93 ---LDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
LDRE +S + ++ D R +++ + D+ND+AP F+ Y + E+
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQF----FAIDSARGIVTVIRELDYETTQAYQ 202
G+P+ V A+D D G G+V Y F+ID+ G++ + R LD+E + ++
Sbjct: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNIYEHSPPGTTVRII 258
L V A D L + A + + + D D P IF++ S + E +PPG V I
Sbjct: 330 LVVQARDGGAHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARI 388
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
+ D D G + ++ G + FAL V+ L + R + + L V T+
Sbjct: 389 SVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
++A F + V D+NDNAP F+ Y L +V ++V +D
Sbjct: 447 SGSPPLRAEA----AFVLHVTDVNDNAPAFDRQLYRP--EPLPEVALPGSFVVRVTARDP 500
Query: 379 NLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
+ G N L G ++H F I PTS I A LDYE + + A +
Sbjct: 501 DQGTNGQVTYSLAPGAHTHWFSIDPTSG------IITTAASLDYELEPQPQLIVVATDGG 554
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+P A V + L + NDN P F + YN SL E GT L V
Sbjct: 555 LPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV 600
Score = 135 bits (341), Expect = 7e-32
Identities = 117/414 (28%), Positives = 186/414 (44%), Gaps = 32/414 (7%)
Query: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETKSEF---TVEFSVSDHQGVITRKVNIQVGDV 125
V G + FA++ +G ++L +PLD E + TV G +V +QV D
Sbjct: 1370 VGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDE 1429
Query: 126 NDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPD-LGAGGSVLYSF---QPPSQFFAID 181
N++AP F P ++ +PEN G ++ A+D D G V Y +PP +D
Sbjct: 1430 NEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLD 1489
Query: 182 SARGIVTVIRELDYETTQAYQLTVNATDQ--DKTRPLSTLANLAIIITDVQDMDPIFINL 239
+ G ++ R LD ETT A L V ATD+ + +R + + + +TD D P+F +
Sbjct: 1490 ARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS- 1548
Query: 240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLL 299
P + E PPG + A D D G + Y + SG + F L +G L++ L
Sbjct: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPL 1607
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +LTV + D + T + V D+ND AP F EYSV + E
Sbjct: 1608 DREQ---RAEHVLTV----VASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRE 1660
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISP-TSVQGKADIRIRVAIP 418
G +L L ++ D D +G N +V G +S F + P T V +
Sbjct: 1661 NNPPGTSL-LTLRATDPD--VGANG--QVTYGGVSSESFSLDPDTGV-------LTTLRA 1708
Query: 419 LDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYE 471
LD E + + ++A + P + + V++ + +END+ P F ++ + E
Sbjct: 1709 LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE 1762
Score = 133 bits (334), Expect = 5e-31
Identities = 129/479 (26%), Positives = 211/479 (44%), Gaps = 49/479 (10%)
Query: 46 TPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVE- 104
T G+ V Q+ AQ D P+ + ++ E AS F +EP +G +W+R LDRE + + ++
Sbjct: 1013 TTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKV 1072
Query: 105 FSVSDHQGVI-----TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
+VS + + T V + + + N+++P P + + EN P GT + V ATD
Sbjct: 1073 MAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR 1132
Query: 160 DLGAGGSVLYSFQP---PSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPL 216
D G G + YS Q S+ F I G VT ++ LD E +YQL V D P
Sbjct: 1133 DSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP-PR 1191
Query: 217 STLANLAIIITDVQDMDPIFINLPYSTN------IYEHSPPGTTVRIITAIDQDKGRPRG 270
ST + + + D+ D P F+ + + + PPGT V + A D D+G
Sbjct: 1192 STTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGT 1251
Query: 271 IGYTIVSGNTNSIFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDAT 329
I YT+ +G + +F+L SG +LT L+ E P Y +LT+ + P A+
Sbjct: 1252 ILYTL-TGPGSELFSLHPHSGELLTAAPLIRAERPHY----VLTLSAHDQGSP--PRSAS 1304
Query: 330 VTTTFNILVI--------DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
+ +L D+ + P ++ V +T A G + V E G
Sbjct: 1305 LQLLVQVLPSARLAEPPPDLAERDP---AAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAG 1361
Query: 382 LNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
+ ++ LVG + + G R+ +A PLD+E + L P
Sbjct: 1362 VGALTYT-LVGGADPEGTFALDAASG----RLYLARPLDFEAGPPWRA-LTVRAEGPGGA 1415
Query: 442 G--YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTAGPLSSPGP 498
G +V++ + +EN++ P F++ ++L EN G ++ T F A PGP
Sbjct: 1416 GARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT------FRASDADGPGP 1468
Score = 132 bits (333), Expect = 6e-31
Identities = 122/475 (25%), Positives = 201/475 (42%), Gaps = 31/475 (6%)
Query: 16 VLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD--NDPLVFGVSGEE 73
V+I G G+ R P F + I E+ P G+ + A N P+ + +
Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEA--TIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGN 2110
Query: 74 ASRFFAVEPDTGVVWLR--QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPT 131
F+++P TG + +R + LD E + + + + D NDNAP
Sbjct: 2111 EKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPR 2170
Query: 132 FHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVT 188
F Y +PE+ P+ P+ V A D D G+GG + YS QP F +D G +T
Sbjct: 2171 FLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTIT 2230
Query: 189 VIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
LD E +L + ATD+ + + A L +++ D D P I P+ + E
Sbjct: 2231 TTAILDREIWAETRLVLMATDRGSPALVGS-ATLTVMVIDTNDNRPT-IPQPWELRVSED 2288
Query: 249 SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSH 308
+ G+ + +T D D G + Y + F++ G ++L G LD E
Sbjct: 2289 ALLGSEIAQVTGNDVDSGPV--LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ 2346
Query: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP 368
+L G P + T +LV D+NDNAP F+ S Y V + E G A+
Sbjct: 2347 LQLLAHDG--------PHEGRANLT--VLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAI- 2395
Query: 369 LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428
L + D+D G N Y + + + F + P + I + L ++ D
Sbjct: 2396 LSVSATDRDS--GANGHIS-YHLASPADGFSVDPNN---GTLFTIVGTVALGHDGSGAVD 2449
Query: 429 FDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
L A + P A V + L ++ND+ P F+ Y +++ E++ G+++LT+
Sbjct: 2450 VVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
Score = 129 bits (323), Expect = 9e-30
Identities = 124/467 (26%), Positives = 202/467 (43%), Gaps = 42/467 (8%)
Query: 36 FDTYLLISEDTPV----GSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVW 88
FD L E P GS V ++ A+D D N + + ++ + +F+++P +G++
Sbjct: 472 FDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIIT 531
Query: 89 LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
LD E + + + +D + V++ + DVNDN P F Y+ +PE T
Sbjct: 532 TAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGT 591
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSF--------QPPSQFFAIDSARGIVTVIRELDYET 197
GT V ATD D G G + YS PP F ID+ G V R LD +
Sbjct: 592 QPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQ 648
Query: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
++ TV A D L ++ + + ++D D P F Y+ +I SPPGT V
Sbjct: 649 GPSSFDFTVTAVDGGG---LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKG 316
+ A D D+G + Y I++GN+ +F LD SG+LT+ L R ++ + G
Sbjct: 706 RLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARR----ANSVVQLEIG 761
Query: 317 TELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDK 376
E D A + +I ++ P F +Y ++ E G + + +V
Sbjct: 762 AE---DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTS----VGIVQA 814
Query: 377 DENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
G + + L G + + S +V G ++ PLD E + + ++ A
Sbjct: 815 HNPPGRLAPVTLSLSGGDPRG-LFSLDAVSG----LLQTLRPLDRELLGPVLELEVRAGS 869
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
VP A+V++ L + NDN P F P + L N GT + T+
Sbjct: 870 GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916
Score = 110 bits (276), Expect = 2e-24
Identities = 131/469 (27%), Positives = 196/469 (41%), Gaps = 49/469 (10%)
Query: 18 ISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEAS 75
+ G WGQ L L I E+ P G+ + + A PL++ +S +E S
Sbjct: 37 VPGAWGQAGSLD----------LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGS 86
Query: 76 RF---FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
A++ +GVV + LDRE + + F+ G T +V ++V D+ND+AP F
Sbjct: 87 GVGTDLAIDEHSGVVRTARVLDREQRDRY--RFTAVTPDGA-TVEVTVRVADINDHAPAF 143
Query: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQFFAIDSARG----- 185
++++PE+T GT + A D D G G+ Y S + F +++ G
Sbjct: 144 PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTP 203
Query: 186 --IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 243
+ V ELD E Y L + A D + P A L + + D+ D P F Y
Sbjct: 204 VPELVVTGELDRENRSHYMLQLEAYD-GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 262
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNTNSIFALDYISGVLTLNGLLDR 301
+ E PG+ V + A D D G + Y I + F++D +G+L L LD
Sbjct: 263 VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDF 322
Query: 302 ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE----FNSSEYSVAI 357
E L V+ + A VT + V D NDN P F S++ S +
Sbjct: 323 EQRRVHE---LVVQARDGGAHPELGSAFVT----VHVRDANDNQPSMTVIFLSADGSPQV 375
Query: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAI 417
+E A G L I V D D+ G + V L G H + S Q + VA
Sbjct: 376 SEAAPPG-QLVARISVSDPDD--GDFAHVNVSLEGGEGHFAL----STQDSVIYLVCVAR 428
Query: 418 PLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLY 465
LD E D Y+ + A +S P A + + + NDN P F + LY
Sbjct: 429 RLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
Score = 108 bits (271), Expect = 9e-24
Identities = 135/482 (28%), Positives = 207/482 (42%), Gaps = 59/482 (12%)
Query: 38 TYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSG-EEASRFFAVEPDTGVVWLRQPL 93
T+L ++E+ P G+SV ++ A D D+ P L + + E S+ F + P TG V Q L
Sbjct: 1110 TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTL 1169
Query: 94 DRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYS------VRIPEN 144
DRE +S + + V D T V++ V D+NDN+PTF + +++P+
Sbjct: 1170 DREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDR 1229
Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIVTVIRELDYETTQAYQL 203
P GT + + A DPD G G++LY+ P S+ F++ G + L Y L
Sbjct: 1230 VPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289
Query: 204 TVNATDQDKTRPLSTL---------ANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPGT 253
T++A DQ ++L A LA D+ + DP + + + E PG+
Sbjct: 1290 TLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGS 1349
Query: 254 TVRIITAIDQDKGRPRGIG---YTIVSG-NTNSIFALDYISGVLTLNGLLDRE-NPLYSH 308
+ + A + P G+G YT+V G + FALD SG L L LD E P +
Sbjct: 1350 LLGSVAAPE-----PAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWR- 1403
Query: 309 GFILTVKGTELNDDRTPSDATV-TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL 367
LTV+ P A + V D N++AP F ++A+ E + G AL
Sbjct: 1404 --ALTVRA------EGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAAL 1455
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII------SPTSVQGKADIRIRVAIPLDY 421
F + D D G NS L+ + S D A+ L
Sbjct: 1456 YTF-RASDAD-GPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLV 1513
Query: 422 ETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
E DR AN S ++ + +ENDN P+F+ P + L E+ G + L
Sbjct: 1514 EATDRP-----ANAS-RRRAARVSARVFVTDENDNAPVFASP-SRVRLPEDQPPGPAALH 1566
Query: 482 VL 483
V+
Sbjct: 1567 VV 1568
Score = 107 bits (267), Expect = 3e-23
Identities = 98/371 (26%), Positives = 160/371 (43%), Gaps = 40/371 (10%)
Query: 127 DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSAR 184
+ P F I EN P GTPI A G G + YS ++ F+I +
Sbjct: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPST 2121
Query: 185 GIVTV--IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
G +TV LD+E + +L + A ++ L + + D D P F+ Y
Sbjct: 2122 GAITVRSAEGLDFEVSPRLRLVLQA----ESGGAFAFTVLTLTLQDANDNAPRFLRPHYV 2177
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN-TNSIFALDYISGVLTLNGLLDR 301
+ E P + + A D D+G I Y++ + +F +D +G +T +LDR
Sbjct: 2178 AFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDR 2237
Query: 302 ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELA 361
E + L + T+ AT+T ++VID NDN P + + ++E A
Sbjct: 2238 EIWAETR---LVLMATDRGSPALVGSATLT----VMVIDTNDNRPTI-PQPWELRVSEDA 2289
Query: 362 QVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ-----GKADIRIRVA 416
+G + QV D + G + ++SP+ Q G+ R+ +
Sbjct: 2290 LLGSEIA---QVTGNDVDSGPVLWY------------VLSPSGPQDPFSVGRYGGRVSLT 2334
Query: 417 IPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVG 476
PLD+E DRY L A++ H G A + + + + NDN P FSQ LY + L E+ G
Sbjct: 2335 GPLDFEQCDRYQLQLLAHDG--PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPG 2392
Query: 477 TSVLTVLVSPR 487
+++L+V + R
Sbjct: 2393 SAILSVSATDR 2403
Score = 107 bits (267), Expect = 3e-23
Identities = 78/278 (28%), Positives = 134/278 (48%), Gaps = 18/278 (6%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
P FT + + + EDTPVG+ + + A D D P + F VS + S F ++ +G
Sbjct: 2600 PVFTRASYR--VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSG 2657
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
+ L LD ET++ + +D G V I+V DVND+ P F S + E
Sbjct: 2658 TLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAE 2717
Query: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS------QFFAIDSARGIVTVIRELDYET 197
N P GT + ++A D D GA G + YS + FA++S+ G + DYE
Sbjct: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
Query: 198 TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
T++++L V A D LS +++++T + DP+F+ + + E + G ++
Sbjct: 2778 TESFRLLVGAADAGN---LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGH 2834
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
+ A D+D G + Y++ + ++ F ++ +G L L
Sbjct: 2835 VQATDEDGGADGLVLYSLAT--SSPYFGINQTTGALYL 2870
Score = 107 bits (266), Expect = 4e-23
Identities = 121/452 (26%), Positives = 187/452 (41%), Gaps = 45/452 (9%)
Query: 42 ISEDTPVGS---SVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95
+S + P G ++T L A D D N L + + + S F ++ +G +PLDR
Sbjct: 1756 LSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
Query: 96 ETKSEFTVEFSVSDH-QGVI--TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
E + F + D Q + T + + V D ND+AP F YSV +PE+ P GT +
Sbjct: 1816 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
Query: 153 IVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
+ A DPD GA G V Y + F ++ + G + LD E +Y +V+A D
Sbjct: 1876 QLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGA 1935
Query: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP----PGTTVRIITAIDQDKGR 267
PLST ++ I + DV D P F P + P P + + A D+D G
Sbjct: 1936 AAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGA 1995
Query: 268 PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP--LYSHGFILTVKGTELNDDRTP 325
I Y + +G +D +G + + +P L +L + T+L R
Sbjct: 1996 NASILYRL-AGTPPPGTTVDSYTGEIRV-----ARSPVALGPRDRVLFIVATDLG--RPA 2047
Query: 326 SDATVTTTFNILVIDINDNA---PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
AT ++++ + A P F + I E A G + V + + G
Sbjct: 2048 RSAT-----GVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI-----VSPRAVHAGG 2097
Query: 383 NSMFEVY--LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
+ Y L GN F I P++ I +R A LD+E R L A
Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPST----GAITVRSAEGLDFEVSPRLRLVLQAESG--GA 2151
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
+ + +TL + NDN P F +P Y L E+
Sbjct: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPES 2183
Score = 106 bits (264), Expect = 6e-23
Identities = 105/431 (24%), Positives = 185/431 (42%), Gaps = 26/431 (6%)
Query: 42 ISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
+ ED G+SV + A + P+ +SG + F+++ +G++ +PLDRE
Sbjct: 799 VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
Query: 100 EFTVEFSVSDHQGV----ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
+E V GV +V + + DVNDN+P F +V +P NT GTPI+ +
Sbjct: 859 P-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
Query: 156 ATDPDLGAGGSVLYS-FQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
A DPD G V ++ F +D G V ++R L A++L + A D +
Sbjct: 918 ALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD-GGSP 976
Query: 215 PLSTLANLAIIITDV--QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
P ++ L +++ DV + + P F + Y ++ + GT V + A D G I
Sbjct: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PIT 1033
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y + + +S F L+ SG L + LDRE ++ V G++ T T
Sbjct: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAE----LGQQTGTA 1089
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
T + +++ N+++P + +A+ E G ++ + D+D + + +
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR-VFATDRDSGPNGRLTYSLQQLS 1148
Query: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLI 451
+S F I P + + + LD E Y + + P V + ++
Sbjct: 1149 EDSKAFRIHPQTGE------VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202
Query: 452 NENDNRPIFSQ 462
+ NDN P F Q
Sbjct: 1203 DLNDNSPTFLQ 1213
Score = 97.8 bits (242), Expect = 2e-20
Identities = 116/466 (24%), Positives = 196/466 (42%), Gaps = 38/466 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
IS +P G++V +L A D D L + + + F ++ +G++ + PL R
Sbjct: 694 ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRAN 753
Query: 99 SEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
S +E D G+ +V+I + P F Y +PE+ GT + IV
Sbjct: 754 SVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQ 813
Query: 156 ATDPDLGAGGSVLYSFQ--PPSQFFAIDSARGIVTVIRELDYETT-QAYQLTVNATDQDK 212
A +P G V S P F++D+ G++ +R LD E +L V A
Sbjct: 814 AHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSG-- 870
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
P +A + +++ DV D P F + + ++ PGT + + A+D D G +
Sbjct: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
+T+++G + F +D +G + L PL G E D +P T
Sbjct: 931 FTLLAGGGGA-FTVDPTTGHVRLM------RPLGPSGGPAHELELEARDGGSPP-RTSHF 982
Query: 333 TFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
++V D+ AP FNS Y V + G + L +Q D G + +
Sbjct: 983 RLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQV-LQVQAQAPD---GGPITYHLAA 1038
Query: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA----NESVPDHVGYAKV 446
G +S F + P S + +R A LD E + Y + A + G A V
Sbjct: 1039 EGASSP-FGLEPQS----GWLWVRAA--LDREAQELYILKVMAVSGSKAELGQQTGTATV 1091
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTAGP 492
+++++N+N++ P S+ +++ EN GTSV V + R +GP
Sbjct: 1092 RVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR-DSGP 1136
Score = 91.7 bits (226), Expect = 2e-18
Identities = 114/464 (24%), Positives = 194/464 (41%), Gaps = 41/464 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ + P G+ VT L A+D D N +++ ++G S F++ P +G + PL R +
Sbjct: 1226 VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP-GSELFSLHPHSGELLTAAPLIRAER 1284
Query: 99 SEFTVEFSVSDHQGVITRKVNIQV-------GDVNDNAPTFHNQPYSVRIP--------E 143
+ + S D QG R ++Q+ + + P + + +P E
Sbjct: 1285 PHYVLTLSAHD-QGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
Query: 144 NTPVGTPIFIVNATDP-DLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
G+ + V A +P +GA L P FA+D+A G + + R LD+E ++
Sbjct: 1344 GLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWR 1403
Query: 203 -LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
LTV A + L + + + D + P F P + + E+ PG + A
Sbjct: 1404 ALTVRAEGPGGAG--ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
Query: 262 DQDKGRPRG-IGYTIVSGNTN-SIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D P + Y ++ LD +G L+ LDRE + +L V+ T+
Sbjct: 1462 DADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET---TPALLLLVEATDR 1518
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
+ + A + + V D NDNAP F +S V + E G P + VV +D +
Sbjct: 1519 PANASRRRAARVSA-RVFVTDENDNAPVF-ASPSRVRLPEDQPPG---PAALHVVARDPD 1573
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVP 438
LG + L HF + ++ + V PLD E + + A++ P
Sbjct: 1574 LGEAARVSYRLASGGDGHFRLHSSTGA------LSVVRPLDREQRAEHVLTVVASDHGSP 1627
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ +++ + ND P F Q Y++ L EN GTS+LT+
Sbjct: 1628 PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTL 1671
Score = 52.8 bits (125), Expect = 8e-07
Identities = 67/251 (26%), Positives = 99/251 (39%), Gaps = 31/251 (12%)
Query: 245 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-------SGNTNSIFALDYISGVLTLNG 297
I E P GT + I+A G P G ++ + A+D SGV+
Sbjct: 51 IDEEQPAGTLIGDISA-----GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
Query: 298 LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 357
+LDRE + T TP ATV T + V DIND+AP F + ++ +
Sbjct: 106 VLDREQ---RDRYRFTAV--------TPDGATVEVT--VRVADINDHAPAFPQARAALQV 152
Query: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT--SVQGKADIRIRV 415
E G PL +D + G L G+ + T G + V
Sbjct: 153 PEHTAFGTRYPL---EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209
Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
LD E Y L A + P A + +TL++ ND+ P F+Q Y+ + E++
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 475 VGTSVLTVLVS 485
G+ VL V S
Sbjct: 270 PGSPVLQVFAS 280
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 155 bits (391), Expect = 1e-37
Identities = 131/437 (29%), Positives = 206/437 (47%), Gaps = 43/437 (9%)
Query: 67 FGVSGEEASRFFAVEPDTGVVWLRQPLDRET------KSEFTVEFSVSDHQGVITRKVNI 120
F V A + P +G++ +Q +DR+ K ++E S + + + +
Sbjct: 61 FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICV---IKV 117
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
++ D+NDNAP+F + I E GT I + +A DPD G+ G Y P F
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLE 177
Query: 181 DSARG------IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP 234
RG + V + LD ET Y + A D L T+ L+I +TD D +P
Sbjct: 178 IKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTV-GLSIKVTDSNDNNP 236
Query: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFALDYISG 291
+F Y+ ++ E+SPP T V + A D D+G + Y+ V+ T +F +D SG
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSG 296
Query: 292 VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN-- 349
++T+ G LD E H + L V+ +L + P+ VT + V+D NDN P N
Sbjct: 297 LVTVTGALDYEE---GHVYELDVQAKDLGPNSIPAHCKVT----VSVLDTNDNPPVINLL 349
Query: 350 --SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
+SE V ++E A G+ + L ++V D+D GLN + L+GN P +Q
Sbjct: 350 SVNSEL-VEVSESAPPGYVIAL-VRVSDRDS--GLNGRVQCRLLGN-------VPFRLQE 398
Query: 408 -KADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLY 465
++ I V LD E D+Y+ + A + VP + + +ENDN P FS+P Y
Sbjct: 399 YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYY 458
Query: 466 NISLYENVTVGTSVLTV 482
+ + EN T G +L+V
Sbjct: 459 QVIVQENNTPGAYLLSV 475
Score = 140 bits (353), Expect = 3e-33
Identities = 122/446 (27%), Positives = 199/446 (44%), Gaps = 37/446 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEAS--RFFAVEPDT-------GVVWLR 90
L ISE G+ + A D D+ FGV E + F +E T + +
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGS--FGVQTYELTPNELFGLEIKTRGDGSRFAELVVE 193
Query: 91 QPLDRETKSEFTVEFSV---SDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ LDRET+S ++ + D + T ++I+V D NDN P F Y+V +PEN+P
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPP 253
Query: 148 GTPIFIVNATDPDLGAGGSVLYSF-----QPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
TP+ +NA+DPD G G V+YSF + F ID G+VTV LDYE Y+
Sbjct: 254 NTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYE 313
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHS---PPGTTVRIIT 259
L V A D + + + + D D P+ L ++ + E S PPG + ++
Sbjct: 314 LDVQAKDLG-PNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVR 372
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D+D G + ++ + + S +L ++G LDRE + LT+ +
Sbjct: 373 VSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTIL-VDGRLDREQ---HDQYNLTI---QA 425
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
D P +F +L+ D NDN P F+ Y V + E G L + V +D +
Sbjct: 426 RDGGVPM-LQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL---LSVSARDPD 481
Query: 380 LGLNSMFEVYLVGNNSHHF-IISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SV 437
LGLN +V + + + S+ + I ++E ++F + A + +
Sbjct: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSG-DIYALRSFNHEQTKAFEFKVLAKDGGL 540
Query: 438 PDHVGYAKVKITLINENDNRPIFSQP 463
P A V++ +++ NDN P+ + P
Sbjct: 541 PSLQSNATVRVIILDVNDNTPVITAP 566
Score = 64.3 bits (155), Expect = 3e-10
Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 24/276 (8%)
Query: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG---RPR-GI 271
L L LAI+ T + INL YS + E GT + + ++ G PR
Sbjct: 6 LPVLLLLAILWTQAAAL----INLKYS--VEEEQRAGTVIANVAKDAREAGFALDPRQAS 59
Query: 272 GYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFILTVKGTELNDDRTPSDATV 330
+ +VS + + ++ SG+L +DR+ S I++++ S +
Sbjct: 60 AFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLE--------VMSSSME 111
Query: 331 TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
+ + D+NDNAP F +++ + I+E A G +PL + G+ + Y
Sbjct: 112 ICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGV----QTYE 167
Query: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKIT 449
+ N + T G + V LD ET Y F + A + P +G + I
Sbjct: 168 LTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIK 227
Query: 450 LINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
+ + NDN P+FS+ Y +S+ EN T V+ + S
Sbjct: 228 VTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNAS 263
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/219 (26%), Positives = 92/219 (42%), Gaps = 24/219 (10%)
Query: 34 HFFDTY--LLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEAS-----RFFAVEPD 83
HF Y +++ E+ G+ + + A+D D N + + + + + ++ P+
Sbjct: 452 HFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPN 511
Query: 84 TGVVWLRQPLDRETKSEFTVEFSVSDHQGVI-----TRKVNIQVGDVNDNAPTFHNQPY- 137
+G ++ + + E F EF V G + V + + DVNDN P P
Sbjct: 512 SGDIYALRSFNHEQTKAF--EFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLI 569
Query: 138 ----SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRE 192
V IP N+ +G + +V A D D G G V Y + FF ID G V R
Sbjct: 570 NGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRT 629
Query: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD 231
+ +Y+L V A D KT LS A + I ++ D
Sbjct: 630 FGESSKSSYELIVVAHDHGKT-SLSASALVLIYLSPALD 667
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 155 bits (391), Expect = 1e-37
Identities = 131/437 (29%), Positives = 206/437 (47%), Gaps = 43/437 (9%)
Query: 67 FGVSGEEASRFFAVEPDTGVVWLRQPLDRET------KSEFTVEFSVSDHQGVITRKVNI 120
F V A + P +G++ +Q +DR+ K ++E S + + + +
Sbjct: 61 FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICV---IKV 117
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
++ D+NDNAP+F + I E GT I + +A DPD G+ G Y P F
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLE 177
Query: 181 DSARG------IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP 234
RG + V + LD ET Y + A D L T+ L+I +TD D +P
Sbjct: 178 IKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTV-GLSIKVTDSNDNNP 236
Query: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFALDYISG 291
+F Y+ ++ E+SPP T V + A D D+G + Y+ V+ T +F +D SG
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSG 296
Query: 292 VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN-- 349
++T+ G LD E H + L V+ +L + P+ VT + V+D NDN P N
Sbjct: 297 LVTVTGALDYEE---GHVYELDVQAKDLGPNSIPAHCKVT----VSVLDTNDNPPVINLL 349
Query: 350 --SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
+SE V ++E A G+ + L ++V D+D GLN + L+GN P +Q
Sbjct: 350 SVNSEL-VEVSESAPPGYVIAL-VRVSDRDS--GLNGRVQCRLLGN-------VPFRLQE 398
Query: 408 -KADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLY 465
++ I V LD E D+Y+ + A + VP + + +ENDN P FS+P Y
Sbjct: 399 YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYY 458
Query: 466 NISLYENVTVGTSVLTV 482
+ + EN T G +L+V
Sbjct: 459 QVIVQENNTPGAYLLSV 475
Score = 140 bits (353), Expect = 3e-33
Identities = 122/446 (27%), Positives = 199/446 (44%), Gaps = 37/446 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEAS--RFFAVEPDT-------GVVWLR 90
L ISE G+ + A D D+ FGV E + F +E T + +
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGS--FGVQTYELTPNELFGLEIKTRGDGSRFAELVVE 193
Query: 91 QPLDRETKSEFTVEFSV---SDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ LDRET+S ++ + D + T ++I+V D NDN P F Y+V +PEN+P
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPP 253
Query: 148 GTPIFIVNATDPDLGAGGSVLYSF-----QPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
TP+ +NA+DPD G G V+YSF + F ID G+VTV LDYE Y+
Sbjct: 254 NTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYE 313
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHS---PPGTTVRIIT 259
L V A D + + + + D D P+ L ++ + E S PPG + ++
Sbjct: 314 LDVQAKDLG-PNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVR 372
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D+D G + ++ + + S +L ++G LDRE + LT+ +
Sbjct: 373 VSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTIL-VDGRLDREQ---HDQYNLTI---QA 425
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
D P +F +L+ D NDN P F+ Y V + E G L + V +D +
Sbjct: 426 RDGGVPM-LQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL---LSVSARDPD 481
Query: 380 LGLNSMFEVYLVGNNSHHF-IISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SV 437
LGLN +V + + + S+ + I ++E ++F + A + +
Sbjct: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSG-DIYALRSFNHEQTKAFEFKVLAKDGGL 540
Query: 438 PDHVGYAKVKITLINENDNRPIFSQP 463
P A V++ +++ NDN P+ + P
Sbjct: 541 PSLQSNATVRVIILDVNDNTPVITAP 566
Score = 64.3 bits (155), Expect = 3e-10
Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 24/276 (8%)
Query: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG---RPR-GI 271
L L LAI+ T + INL YS + E GT + + ++ G PR
Sbjct: 6 LPVLLLLAILWTQAAAL----INLKYS--VEEEQRAGTVIANVAKDAREAGFALDPRQAS 59
Query: 272 GYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFILTVKGTELNDDRTPSDATV 330
+ +VS + + ++ SG+L +DR+ S I++++ S +
Sbjct: 60 AFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLE--------VMSSSME 111
Query: 331 TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
+ + D+NDNAP F +++ + I+E A G +PL + G+ + Y
Sbjct: 112 ICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGV----QTYE 167
Query: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKIT 449
+ N + T G + V LD ET Y F + A + P +G + I
Sbjct: 168 LTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIK 227
Query: 450 LINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
+ + NDN P+FS+ Y +S+ EN T V+ + S
Sbjct: 228 VTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNAS 263
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/219 (26%), Positives = 92/219 (42%), Gaps = 24/219 (10%)
Query: 34 HFFDTY--LLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEAS-----RFFAVEPD 83
HF Y +++ E+ G+ + + A+D D N + + + + + ++ P+
Sbjct: 452 HFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPN 511
Query: 84 TGVVWLRQPLDRETKSEFTVEFSVSDHQGVI-----TRKVNIQVGDVNDNAPTFHNQPY- 137
+G ++ + + E F EF V G + V + + DVNDN P P
Sbjct: 512 SGDIYALRSFNHEQTKAF--EFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLI 569
Query: 138 ----SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRE 192
V IP N+ +G + +V A D D G G V Y + FF ID G V R
Sbjct: 570 NGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRT 629
Query: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD 231
+ +Y+L V A D KT LS A + I ++ D
Sbjct: 630 FGESSKSSYELIVVAHDHGKT-SLSASALVLIYLSPALD 667
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 152 bits (384), Expect = 7e-37
Identities = 126/465 (27%), Positives = 218/465 (46%), Gaps = 33/465 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEE-ASRFFAVEPDTGVVWLRQPLDRETKS 99
I+ED+ G VT + D+D N +F + E FA++ +TGVV L + LD E +
Sbjct: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
Query: 100 EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
E+ + +SD + ++V DVNDN P F Y V +PE+ PVG + ++AT
Sbjct: 1960 EYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT-- 2017
Query: 160 DLGAGGSVLYSFQPPSQFFAIDSARG-IVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
DL + ++ Y S+ F+ID G I T+ L +T Q V A+D L
Sbjct: 2018 DLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-DLRA 2076
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVS 277
L + I I D+ + P F Y+ ++ E + G+T+ + ID D R + Y+I+S
Sbjct: 2077 LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIIS 2136
Query: 278 GNTNSIFALD----------YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
GN+ + F ++ G L L LDRE SH ++ L D
Sbjct: 2137 GNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA-SHELVI------LASDSGCPP 2189
Query: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
+ T +I V+D+NDN P F+S Y + E +G + + + D+D ++
Sbjct: 2190 LSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITV-VSANDRDTGSHAEIIYN 2248
Query: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
+ H ++ T V + + PLDYE + ++ + A+++ H +A V
Sbjct: 2249 IISGNEKGHFYLEENTGV-------LYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF 2301
Query: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFTAGP 492
++++++ND+ P F ++ + EN+ + +++ ++ F AGP
Sbjct: 2302 VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD-FDAGP 2345
Score = 146 bits (368), Expect = 5e-35
Identities = 130/465 (27%), Positives = 211/465 (45%), Gaps = 36/465 (7%)
Query: 35 FFDTYLLIS--EDTPVGSSVTQLLAQDMDNDPLVFGV-----SGEEASRFFAVEPDTGVV 87
F D ++IS E+ P+G+ V A+D D L + S + F + P G +
Sbjct: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTL 1114
Query: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK------VNIQVGDVNDNAPTFHNQPYSVRI 141
LDRE+ + + SD +T + I + DVND+ PTF + P + +
Sbjct: 1115 VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHV 1173
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQ 199
E+ VG+ + + A DPD G G V YS ++ F +D + G++T LDYE
Sbjct: 1174 KEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKT 1233
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ LTV A D D T LS+ L + + DV D P+F Y ++ E+ PG V +
Sbjct: 1234 QHILTVLALD-DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVE 1292
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
A+D+D G + + I+ G + +F ++ +G + +LDRE F L V +
Sbjct: 1293 ALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDRE---IQEVFTLRVL---V 1346
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
D PS + TTT V D ND+APEF S Y + + E + + V+ D +
Sbjct: 1347 RDGGFPS-LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP----EVVYTVLASDMD 1401
Query: 380 LGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SV 437
G N E +++ GN F I+ S + + LD E + + + ++
Sbjct: 1402 AGNNRAVEYHIIDGNTDECFTINEMSGE------LSTTRALDREQISNFTLVILCSDLGD 1455
Query: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
P +++ +++ ND+ P F Y S+ E+ VGT VL +
Sbjct: 1456 PPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
Score = 125 bits (314), Expect = 1e-28
Identities = 125/468 (26%), Positives = 218/468 (46%), Gaps = 46/468 (9%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVV 87
P F+ F+ + + E PVG SV L A D++ N+ + + + +S+ F+++P G +
Sbjct: 1990 PVFSQDFYQ--VTVPESIPVGYSVLTLSATDLESNENISYRILS--SSKEFSIDPKNGTI 2045
Query: 88 WLRQP---LDRETKSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
+ P LD + ++F VE S + + V I + D+N+ AP F + Y++ + E
Sbjct: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
Query: 144 NTPVGTPIFIVNATDPDLGA----------GGSVLYSFQPPSQFFAID---SARGIVTVI 190
+ VG+ + + D D G+ +F ++FF + G + ++
Sbjct: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
LD E + +++L + A+D PLS+ A ++I + DV D P F +L Y T++ E +P
Sbjct: 2166 HSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224
Query: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
G+ + +++A D+D G I Y I+SGN F L+ +GVL L LD E F
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK---MTKF 2281
Query: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
LTV+ + D + F + V+D ND+AP+F S +S + E + +
Sbjct: 2282 TLTVQAS----DAEKKHFSFAVVF-VSVLDDNDHAPQFMFSSFSCIVPENLPISSTI-CS 2335
Query: 371 IQVVDKDE----NLGLNSMFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYET 423
I +D D L + + +L S+ F+I P + DI + LDYE
Sbjct: 2336 INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLT----GDIHAKQI--LDYEN 2389
Query: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYE 471
++Y + A + D V + + ++ PIF+Q Y +L E
Sbjct: 2390 GNKYCLTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPE 2436
Score = 118 bits (296), Expect = 1e-26
Identities = 127/458 (27%), Positives = 191/458 (41%), Gaps = 44/458 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE-------EASRFFAVEPDTGVVWLRQPLD 94
+ ED VG+ V L A D D G++G+ EAS F ++P +G + LD
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDE-----GLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLD 1541
Query: 95 RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
RE +S+ T D +R + + V DVNDN P P+ V + +P
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQT 1601
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
IV A D DLG G+V++SF F+ID G + + E + L + TDQ
Sbjct: 1602 TVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQ 1660
Query: 211 DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
P T L +I + +D+ F + Y + E+ GT++ + A D +
Sbjct: 1661 G--IPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQD-S 1717
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLN--GLLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
+ Y+I SGN + + +L SG LT+ LD E + + E + R
Sbjct: 1718 MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFE----VRNEVQLIVLAESSGHRAYCKV 1773
Query: 329 TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
V L+ D NDN+P F S Y +++E + IQV D + GLN + E
Sbjct: 1774 AV------LIQDENDNSPCFEQSIYQASVSESQLYNAHV---IQVFATDLDSGLNGLIEY 1824
Query: 389 -YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKV 446
L GN F I S I LDYE Y + A ++ +P +
Sbjct: 1825 SILSGNQEEAFQIDALSGV------ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVI 1878
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLV 484
K+ + + NDN P F P + + E+ G V V V
Sbjct: 1879 KVQVTDINDNAPAF-LPSEAVEITEDSLPGVIVTHVSV 1915
Score = 117 bits (292), Expect = 3e-26
Identities = 121/468 (25%), Positives = 202/468 (43%), Gaps = 38/468 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F +D +L +++ V V +LA DMD N + + + F + +G
Sbjct: 1372 PEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG 1428
Query: 86 VVWLRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ + LDRE S FT+ SD VI + ++V D ND++P+F Y
Sbjct: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVI--HLQVRVLDANDHSPSFPTLYYQSS 1486
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQ 199
+ E+ VGT + +++A D D G G Y S F ID G + LD E
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARS 1546
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ + A D ST + + +TDV D DP+ P+ + SP T I+
Sbjct: 1547 QHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606
Query: 260 AIDQDKGRPRGIGYTIVSG--NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
A D D G P G T+V T S+F++D +G + ++NP S F + ++
Sbjct: 1607 ADDLDLG-PNG---TVVFSFAETQSMFSIDKYTGEIQF-----QQNPS-SEYFPIWLQ-L 1655
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
++ D P A TT ++ ++ D F+ Y +TE + G ++ + V
Sbjct: 1656 KVTDQGIP--ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFA 1710
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
+ +SM Y + + + ++S S G+ + ++ LD+E + + A S
Sbjct: 1711 PDSIQDSM--KYSIFSGNEDGVLSLCSKSGQ--LTVKEPKFLDFEVRNEVQLIVLAESS- 1765
Query: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
H Y KV + + +ENDN P F Q +Y S+ E+ V+ V +
Sbjct: 1766 -GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFAT 1812
Score = 115 bits (287), Expect = 1e-25
Identities = 126/463 (27%), Positives = 202/463 (43%), Gaps = 35/463 (7%)
Query: 37 DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPL 93
+ ++ + E PV VT + A+D D N + + VS E++S F ++ + G + L
Sbjct: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
Query: 94 DRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
+ + + + +D QGV + VNIQV ++ + IPEN
Sbjct: 907 SYDYRPSYRMSVIATD-QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
Query: 150 PIFIVNATDP-DLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVN 206
+ ++ ++D G + +S + F IDS+ G + + +ELDYETT Y V
Sbjct: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
TD K LS+ L+I + D D P F + ++ E+ P GT V + A D D
Sbjct: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGS 1085
Query: 267 RPRG-IGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE----LN 320
I Y I S N + F + G L LDRE+ ILTV ++ +
Sbjct: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES---IPTVILTVTASDQAVNVT 1142
Query: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
D R S T I+++D+ND+ P F S + + E VG +L I D DE
Sbjct: 1143 DRRLRS-----LTAQIVILDVNDHNPTFISFP-NAHVKEDVTVG-SLVHHITAHDPDEGR 1195
Query: 381 GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPD 439
+ + L GN + F++ +S + PLDYE ++ + A ++ P
Sbjct: 1196 NGKVTYSI-LSGNENMTFMLDESSG------LLTTTCPLDYEMKTQHILTVLALDDGTPA 1248
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
+ +T+++ ND P+F Q LY S+ EN G V V
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRV 1291
Score = 112 bits (281), Expect = 6e-25
Identities = 118/466 (25%), Positives = 192/466 (41%), Gaps = 38/466 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F H ++ + E+ G VT++ A D D N L F + + F + DTG
Sbjct: 1267 PVFKQHLYEAS--VKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTG 1324
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
V LDRE + FT+ V D T + V D ND+AP F Y + +
Sbjct: 1325 EVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVL 1384
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQA 200
EN ++ V A+D D G +V Y + + F I+ G ++ R LD E
Sbjct: 1385 ENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISN 1443
Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITA 260
+ L + +D P S++ +L + + D D P F L Y +++ E + GT V +++A
Sbjct: 1444 FTLVILCSDLGDP-PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSA 1502
Query: 261 IDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELN 320
+D+D+G Y ++ + F +D +SG L + LDRE H F + +
Sbjct: 1503 VDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARDCSIQ 1560
Query: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
R + T + V D+NDN P + + V ++ + + V D +L
Sbjct: 1561 GSR-----STTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN---QTTVIVRADDLDL 1612
Query: 381 GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
G N V+ F I + +I+ + +Y F ++ V D
Sbjct: 1613 GPNGTV-VFSFAETQSMFSIDKYT----GEIQFQQNPSSEY-------FPIWLQLKVTDQ 1660
Query: 441 VGYAKVKITLI----NENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
A+ L+ D + FS LY + EN GTS++TV
Sbjct: 1661 GIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTV 1706
Score = 102 bits (253), Expect = 1e-21
Identities = 90/326 (27%), Positives = 146/326 (44%), Gaps = 36/326 (11%)
Query: 41 LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
L+ ED P S + + A++ N +P+ + +S + F++ P G + R+PLD ET+
Sbjct: 385 LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 444
Query: 99 SE--FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
TV+ + + +VNI V DVNDN P F +RI + TP GT +++ A
Sbjct: 445 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
Query: 157 TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
D D G G + YS P FAID A G++ + L + LT+ A DQ P
Sbjct: 505 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 563
Query: 216 LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
+ L L ++I + ++ P F +L Y + E P +T + Q + P G
Sbjct: 564 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 616
Query: 271 ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTP 325
+ Y++ +++F + +G + L D E+ Y+ + P
Sbjct: 617 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 666
Query: 326 SDA---TVTTTFNILVIDINDNAPEF 348
D V+TT + V D NDN+P F
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTF 692
Score = 88.2 bits (217), Expect = 2e-17
Identities = 106/400 (26%), Positives = 176/400 (44%), Gaps = 26/400 (6%)
Query: 93 LDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTF----HNQPYSVRIPENT 145
LDRE + + V+D T V + V D+NDN P F + V++ E
Sbjct: 797 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 856
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQL 203
PV + V A DPD G V YS + S F ID+ G + L Y+ +Y++
Sbjct: 857 PVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
Query: 204 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
+V ATDQ PL A + I + + I I E+ P + +I + D
Sbjct: 917 SVIATDQG-VPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDH 975
Query: 264 DKGRPRG-IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDD 322
+ G + ++IV+ + + F +D +G L L+ LD E SH ++ V T+ + +
Sbjct: 976 LQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETT--SH-YLFRVITTDHSKN 1032
Query: 323 RTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
+ S T +I V D ND++P F +++ E +G + +F D+ L
Sbjct: 1033 LSLSS---TVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVF--NAKDDDGSFL 1087
Query: 383 NSMFEVYLVGNN--SHHFIISPTSVQGKADIRI-RVAIPLDYETVDRYDFDLFANESVPD 439
NS + Y+ +N ++ F+I P+ R+ R +IP TV D + +
Sbjct: 1088 NSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDR--- 1144
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
+ +I +++ ND+ P F N + E+VTVG+ V
Sbjct: 1145 RLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLV 1183
Score = 82.4 bits (202), Expect = 9e-16
Identities = 120/498 (24%), Positives = 196/498 (39%), Gaps = 68/498 (13%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
IS+ TP G+++ A+D D N + + ++ + FA++ GV++L L +
Sbjct: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQ 547
Query: 99 SEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAP--TFHNQPYSVRIPENTPVGTPIFI 153
E T+ D QGV + V V + +++P TF + Y V + E+ T +
Sbjct: 548 RELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 606
Query: 154 VNATDPDLG---AGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
A LG A + YS +P S F I G + + R+ DYE+TQ Y V A
Sbjct: 607 TQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
+ + + + + D D P F++ + E P + ITAID D G+
Sbjct: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
Query: 269 RGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ Y ++S G +I+ + + G +G + F+L
Sbjct: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784
Query: 318 ELND------------------------DRTPSDATVTTTFNILVIDINDNAPEF----N 349
EL + DR T + V DINDN P F
Sbjct: 785 ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844
Query: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG--NNSHHFIISPTSVQG 407
E V + E V L V KD + G N+ Y V ++S HF I +
Sbjct: 845 GKELHVKVLEGQPVNM---LVTTVFAKDPDEG-NNAEVTYSVSSEDSSDHFKIDANN--- 897
Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
+IR + DY R + ++ VP G A V I +I + R I SQ + ++
Sbjct: 898 -GEIRTTTILSYDYRPSYRMSV-IATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955
Query: 468 SLYENVTVGTSVLTVLVS 485
+ EN+ T +++++ S
Sbjct: 956 IIPENLK-PTKIMSLIKS 972
Score = 72.4 bits (176), Expect = 1e-12
Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 18/156 (11%)
Query: 154 VNATDPDLGAGGSVLYS-------FQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTV 205
V A+D D G G + YS ++ P Q F ID G + V +++D E A Y L V
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 206 NATDQDKTRP---------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
A D D+ R LS A + + + DV D P+F Y T+I + + PGT +
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV 292
+ A DQD G + Y ++ GN +S+F +D +G+
Sbjct: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 61.6 bits (148), Expect = 2e-09
Identities = 50/157 (31%), Positives = 69/157 (43%), Gaps = 23/157 (14%)
Query: 53 TQLLAQDMDNDPLVF-------GVSGEEASRFFAVEPDTGVVWLRQPLDRETKS---EFT 102
T++ A D D+ F G EA + F ++P G + + Q +DRE +
Sbjct: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
Query: 103 VEFSVSDHQ---------GVITRK--VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
VE D Q G ++ + V + + DVNDN P F+ Y I + T GT I
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 152 FIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGI 186
V ATD D G G+V Y P S F IDS G+
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 59.3 bits (142), Expect = 8e-09
Identities = 42/167 (25%), Positives = 73/167 (43%), Gaps = 16/167 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDP-------------LVFGVSGEEASRFFAVEPDTGVV 87
++ E+ P+ S++ + A D D P L G+S + F ++P TG +
Sbjct: 2322 IVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHD--LFLIDPLTGDI 2379
Query: 88 WLRQPLDRETKSEFTVEFSVSDH-QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
+Q LD E +++ + D + V + + +++ P F Y +PE
Sbjct: 2380 HAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNK 2439
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIREL 193
I V A+D D G G +LYS S FF+++ G + +IR L
Sbjct: 2440 DRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/171 (25%), Positives = 72/171 (42%), Gaps = 16/171 (9%)
Query: 258 ITAIDQDKGRPRGIGYTIVSG----NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
+TA D D G I Y++ G F +D G + ++ +DRE ++ ++
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
Query: 314 VKGTELNDDRTPSDATVTTTFNILVI------DINDNAPEFNSSEYSVAITELAQVGFAL 367
K + + R A V + D+NDN P FN S Y +I++ Q G +
Sbjct: 139 AKDGD--EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 368 PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAI 417
I V+ D++ G+ L+ GN S F I T+ ++ I A+
Sbjct: 197 ---INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAV 244
Score = 37.7 bits (86), Expect = 0.026
Identities = 48/188 (25%), Positives = 78/188 (41%), Gaps = 16/188 (8%)
Query: 185 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD-MDPIFINLP-YS 242
GI+ + L + + L V+A D L+ + N + I Q + P P Y+
Sbjct: 327 GIIYLTLPLSHLESTTLSLMVSAQDGGG---LTAVINADVTIHIFQTTLAPAEFERPKYT 383
Query: 243 TNIYEHSPPGTTVRIITAIDQ-DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDR 301
+YE P + + + A + + P I Y I SG+ F++ G + LD
Sbjct: 384 FLVYEDVPEDSPIGTVKAREPLNSSEP--IFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 441
Query: 302 ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELA 361
E +LTV+ + A +T NI V+D+NDN P F + + I++
Sbjct: 442 ETQPV---VVLTVQA-----QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 493
Query: 362 QVGFALPL 369
G AL L
Sbjct: 494 PPGTALYL 501
Score = 32.3 bits (72), Expect = 1.1
Identities = 14/42 (33%), Positives = 24/42 (57%)
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
A V++ L + NDN P+F+ Y S+ + GT ++ VL +
Sbjct: 161 AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT 202
Score = 30.8 bits (68), Expect = 3.2
Identities = 35/131 (26%), Positives = 52/131 (39%), Gaps = 10/131 (7%)
Query: 358 TELAQVGFALP----LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR- 412
T LA F P L + V +D +G E L + + IS + GK I
Sbjct: 370 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 428
Query: 413 ----IRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 468
IR PLD+ET + A +V IT+++ NDN P F + I
Sbjct: 429 RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
Query: 469 LYENVTVGTSV 479
+ + GT++
Sbjct: 489 ISQTTPPGTAL 499
>gi|14589929 protocadherin 18 precursor [Homo sapiens]
Length = 1135
Score = 152 bits (383), Expect = 1e-36
Identities = 147/455 (32%), Positives = 214/455 (47%), Gaps = 54/455 (11%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR-------QPLD 94
ISE VG+ + A D D A+ FF +E T + + LD
Sbjct: 146 ISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELD 205
Query: 95 RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
RE KS + ++ + SD GV R + I + D NDN+P F Q Y +++ EN+PVGT
Sbjct: 206 RELKSSYELQLTASD-MGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTL 264
Query: 151 IFIVNATDPDLGAGGSVLYSFQPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTV 205
+ +NATDPD GA G ++YSF + F IDS RG +T+ +++DYE T++Y++ V
Sbjct: 265 LLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDV 324
Query: 206 NATDQDKTRPLSTLANLAIII--TDVQDMDP-IFINL-----PYSTNIYEHSPPGTTVRI 257
A D P S A+ III DV D P I INL + I+E P T V +
Sbjct: 325 QAQD---LGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVAL 381
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL-NGLLDRENPLYSHGFILTVKG 316
+ D+D G G + G+ + Y + L L N LDRE + LTV
Sbjct: 382 VRVQDKDSGL-NGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREK---RSEYSLTV-- 435
Query: 317 TELNDDR-TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375
+ +DR TPS +TV F + + DINDN P F S Y I+E G V
Sbjct: 436 --IAEDRGTPSLSTV-KHFTVQINDINDNPPHFQRSRYEFVISENNSPG---AYITTVTA 489
Query: 376 KDENLGLN-----SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
D +LG N ++ E +++G++ ++ S +RI D+E V + F
Sbjct: 490 TDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRI-----FDHEEVSQITFV 544
Query: 431 LFANE--SVPDHVGYAKVKITLINENDNRPIFSQP 463
+ A + S V V +T+I+ENDN P+ P
Sbjct: 545 VEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGP 579
Score = 124 bits (312), Expect = 2e-28
Identities = 122/430 (28%), Positives = 192/430 (44%), Gaps = 38/430 (8%)
Query: 75 SRFFAVEPDTGVVWLRQPLDRETKSE----FTVEFSV----SDHQGVITRKVNIQVGDVN 126
S V D G + + +DRE + ++EF V ++H + + ++V D+N
Sbjct: 74 SPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLF--HIEVEVLDIN 131
Query: 127 DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI------ 180
DN+P F + I E+ VGT I + +A DPD+G YS + FF I
Sbjct: 132 DNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLS-ANDFFNIEVRTRT 190
Query: 181 DSAR-GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINL 239
D A+ + V+RELD E +Y+L + A+D + S + L I I+D D P F
Sbjct: 191 DGAKYAELIVVRELDRELKSSYELQLTASDMGVPQ-RSGSSILKISISDSNDNSPAFEQQ 249
Query: 240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFALDYISGVLTLN 296
Y + E+SP GT + + A D D+G I Y+ VS F +D G LTL
Sbjct: 250 SYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLF 309
Query: 297 GLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVA 356
+D E + + + V+ +L + P+ + I V+D+NDN PE N + S
Sbjct: 310 KQVDYE---ITKSYEIDVQAQDLGPNSIPAHCKII----IKVVDVNDNKPEININLMSPG 362
Query: 357 ITELAQV--GFALPLFIQVVD-KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
E++ + G + F+ +V +D++ GLN L G+ HF + T + + I
Sbjct: 363 KEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHG--HFKLQKTY---ENNYLI 417
Query: 414 RVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINE-NDNRPIFSQPLYNISLYEN 472
LD E Y + A + + K IN+ NDN P F + Y + EN
Sbjct: 418 LTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISEN 477
Query: 473 VTVGTSVLTV 482
+ G + TV
Sbjct: 478 NSPGAYITTV 487
Score = 99.0 bits (245), Expect = 1e-20
Identities = 74/265 (27%), Positives = 113/265 (42%), Gaps = 20/265 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
I E P+ + V + QD D N +V + G + + ++ LDRE +
Sbjct: 369 IFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKR 428
Query: 99 SEFTVEFSVSDHQGV----ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
SE+++ +++ +G + +Q+ D+NDN P F Y I EN G I V
Sbjct: 429 SEYSLTV-IAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTV 487
Query: 155 NATDPDLGAGGSVLYSFQPP-------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
ATDPDLG G V Y+ + + ID + G + +R D+E V A
Sbjct: 488 TATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEA 547
Query: 208 TDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP-----GTTVRIITAID 262
D + L + + + I D D P+ I N E + P G V I AID
Sbjct: 548 RDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAID 607
Query: 263 QDKGRPRGIGYTIVSGNTNSIFALD 287
+D G + IV+GN +IF +D
Sbjct: 608 RDSGVNAELSCAIVAGNEENIFIID 632
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 151 bits (382), Expect = 1e-36
Identities = 143/458 (31%), Positives = 211/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 290 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 349
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 350 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 410 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLL 469
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A D D G
Sbjct: 470 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 528
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 529 PNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 580
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY + E + L I V D D G NS
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 637
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 638 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 690
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P YN S YE V T+ TV+
Sbjct: 691 VTINVVDVNDNKPVFIVPPYNYS-YELVLPSTNPGTVV 727
Score = 124 bits (310), Expect = 3e-28
Identities = 86/276 (31%), Positives = 137/276 (49%), Gaps = 13/276 (4%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPL--VFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G + ++ A D D+ P + + G +A F+++ TG+
Sbjct: 496 PVFTQSFVT--VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGM 553
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y +P
Sbjct: 554 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 612
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN---IYEHSPPGTTVRIIT 259
V A D + S+ A + I + DV D P+FI PY+ + + + PGT V +
Sbjct: 673 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVI 731
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 732 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 120 bits (302), Expect = 2e-27
Identities = 126/490 (25%), Positives = 206/490 (42%), Gaps = 53/490 (10%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 391 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 506
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+ATD D G + Y P + F++D G++TV+++LD E
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKED 566
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y + E+ P TV +IT
Sbjct: 567 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 625
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 626 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 680
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
S A VT I V+D+NDN P F Y+ + + + QV+ D +
Sbjct: 681 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 736
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD 439
G+N+ +VG N+ R +D ET + L V D
Sbjct: 737 TGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLMEKCDVTD 775
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV-------LTVLVSPRFTAGP 492
+G +V + + +FS + N+ + E+VT T + + V+P
Sbjct: 776 -LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIAD 834
Query: 493 LSSPGPTVVR 502
+SSP V+
Sbjct: 835 VSSPTSDYVK 844
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 183/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 109 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 168
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 169 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 228
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 287
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 348 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 398
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 450
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 473 VTVGTSVLTV 482
+ G ++ V
Sbjct: 511 NSPGIQLMKV 520
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 151 bits (382), Expect = 1e-36
Identities = 143/458 (31%), Positives = 211/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 290 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 349
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 350 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 410 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLL 469
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A D D G
Sbjct: 470 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 528
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 529 PNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 580
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY + E + L I V D D G NS
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 637
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 638 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 690
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P YN S YE V T+ TV+
Sbjct: 691 VTINVVDVNDNKPVFIVPPYNYS-YELVLPSTNPGTVV 727
Score = 124 bits (310), Expect = 3e-28
Identities = 86/276 (31%), Positives = 137/276 (49%), Gaps = 13/276 (4%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPL--VFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G + ++ A D D+ P + + G +A F+++ TG+
Sbjct: 496 PVFTQSFVT--VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGM 553
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y +P
Sbjct: 554 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 612
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN---IYEHSPPGTTVRIIT 259
V A D + S+ A + I + DV D P+FI PY+ + + + PGT V +
Sbjct: 673 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVI 731
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 732 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 120 bits (302), Expect = 2e-27
Identities = 126/490 (25%), Positives = 206/490 (42%), Gaps = 53/490 (10%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 391 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 506
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+ATD D G + Y P + F++D G++TV+++LD E
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKED 566
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y + E+ P TV +IT
Sbjct: 567 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 625
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 626 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 680
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
S A VT I V+D+NDN P F Y+ + + + QV+ D +
Sbjct: 681 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 736
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD 439
G+N+ +VG N+ R +D ET + L V D
Sbjct: 737 TGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLMEKCDVTD 775
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV-------LTVLVSPRFTAGP 492
+G +V + + +FS + N+ + E+VT T + + V+P
Sbjct: 776 -LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIAD 834
Query: 493 LSSPGPTVVR 502
+SSP V+
Sbjct: 835 VSSPTSDYVK 844
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 183/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 109 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 168
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 169 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 228
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 287
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 348 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 398
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 450
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 473 VTVGTSVLTV 482
+ G ++ V
Sbjct: 511 NSPGIQLMKV 520
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 151 bits (382), Expect = 1e-36
Identities = 143/458 (31%), Positives = 211/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 279 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 338
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 339 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 398
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 399 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLL 458
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A D D G
Sbjct: 459 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 517
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 518 PNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 569
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY + E + L I V D D G NS
Sbjct: 570 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 626
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 627 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 679
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P YN S YE V T+ TV+
Sbjct: 680 VTINVVDVNDNKPVFIVPPYNYS-YELVLPSTNPGTVV 716
Score = 124 bits (310), Expect = 3e-28
Identities = 86/276 (31%), Positives = 137/276 (49%), Gaps = 13/276 (4%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPL--VFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G + ++ A D D+ P + + G +A F+++ TG+
Sbjct: 485 PVFTQSFVT--VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGM 542
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y +P
Sbjct: 543 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 601
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 602 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 661
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN---IYEHSPPGTTVRIIT 259
V A D + S+ A + I + DV D P+FI PY+ + + + PGT V +
Sbjct: 662 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVI 720
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 721 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 756
Score = 120 bits (302), Expect = 2e-27
Identities = 126/490 (25%), Positives = 206/490 (42%), Gaps = 53/490 (10%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 380 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 439 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 495
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+ATD D G + Y P + F++D G++TV+++LD E
Sbjct: 496 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKED 555
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y + E+ P TV +IT
Sbjct: 556 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 614
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 615 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 669
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
S A VT I V+D+NDN P F Y+ + + + QV+ D +
Sbjct: 670 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 725
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD 439
G+N+ +VG N+ R +D ET + L V D
Sbjct: 726 TGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLMEKCDVTD 764
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV-------LTVLVSPRFTAGP 492
+G +V + + +FS + N+ + E+VT T + + V+P
Sbjct: 765 -LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIAD 823
Query: 493 LSSPGPTVVR 502
+SSP V+
Sbjct: 824 VSSPTSDYVK 833
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 183/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 98 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 157
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 158 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 217
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 218 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 276
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 277 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 336
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 337 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 387
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 439
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 440 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 473 VTVGTSVLTV 482
+ G ++ V
Sbjct: 500 NSPGIQLMKV 509
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 150 bits (379), Expect = 3e-36
Identities = 142/458 (31%), Positives = 212/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 317
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 318 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLL 437
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A+D D G
Sbjct: 438 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 496
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 497 PNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 548
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY+ + E + L I V D D G NS
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 605
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 606 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P N S YE V T+ TV+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCS-YELVLPSTNPGTVV 695
Score = 124 bits (312), Expect = 2e-28
Identities = 89/277 (32%), Positives = 139/277 (50%), Gaps = 15/277 (5%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP--LVFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G +T++ A D D+ P + + G +A F+++ TG+
Sbjct: 464 PVFTQSFVT--VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGM 521
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y+ +P
Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVP 580
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 581 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE----HSPPGTTVRII 258
V A D + S+ A + I + DV D P+FI +P S YE + PGT V +
Sbjct: 641 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQV 698
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 182/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 136
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 255
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 316 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 366
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 418
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 473 VTVGTSVLTV 482
+ G + V
Sbjct: 479 NSPGIQLTKV 488
Score = 115 bits (289), Expect = 8e-26
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 359 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 474
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+A D D G + Y P + F++D G++TV+++LD E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y+ + E+ P TV +IT
Sbjct: 535 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 648
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEF----NSSEYSVAI--TELAQVGFALPLFIQV 373
S A VT I V+D+NDN P F ++ Y + + T V F QV
Sbjct: 649 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVF------QV 698
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
+ D + G+N+ +VG N+ R +D ET + L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLME 737
Query: 434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-------VSP 486
V D +G +V + + +FS + N+ + E+VT T + ++ V+P
Sbjct: 738 KCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796
Query: 487 RFTAGPLSSPGPTVVR 502
+SSP V+
Sbjct: 797 NTEIADVSSPTSDYVK 812
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 150 bits (379), Expect = 3e-36
Identities = 142/458 (31%), Positives = 212/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 317
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 318 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLL 437
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A+D D G
Sbjct: 438 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 496
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 497 PNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 548
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY+ + E + L I V D D G NS
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 605
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 606 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P N S YE V T+ TV+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCS-YELVLPSTNPGTVV 695
Score = 124 bits (312), Expect = 2e-28
Identities = 89/277 (32%), Positives = 139/277 (50%), Gaps = 15/277 (5%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP--LVFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G +T++ A D D+ P + + G +A F+++ TG+
Sbjct: 464 PVFTQSFVT--VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGM 521
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y+ +P
Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVP 580
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 581 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE----HSPPGTTVRII 258
V A D + S+ A + I + DV D P+FI +P S YE + PGT V +
Sbjct: 641 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQV 698
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 182/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 136
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 255
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 316 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 366
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 418
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 473 VTVGTSVLTV 482
+ G + V
Sbjct: 479 NSPGIQLTKV 488
Score = 115 bits (289), Expect = 8e-26
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 359 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 474
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+A D D G + Y P + F++D G++TV+++LD E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y+ + E+ P TV +IT
Sbjct: 535 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 648
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEF----NSSEYSVAI--TELAQVGFALPLFIQV 373
S A VT I V+D+NDN P F ++ Y + + T V F QV
Sbjct: 649 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVF------QV 698
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
+ D + G+N+ +VG N+ R +D ET + L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLME 737
Query: 434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-------VSP 486
V D +G +V + + +FS + N+ + E+VT T + ++ V+P
Sbjct: 738 KCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796
Query: 487 RFTAGPLSSPGPTVVR 502
+SSP V+
Sbjct: 797 NTEIADVSSPTSDYVK 812
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 150 bits (379), Expect = 3e-36
Identities = 142/458 (31%), Positives = 212/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 317
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 318 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLL 437
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A+D D G
Sbjct: 438 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 496
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 497 PNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 548
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY+ + E + L I V D D G NS
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 605
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 606 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P N S YE V T+ TV+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCS-YELVLPSTNPGTVV 695
Score = 124 bits (312), Expect = 2e-28
Identities = 89/277 (32%), Positives = 139/277 (50%), Gaps = 15/277 (5%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP--LVFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G +T++ A D D+ P + + G +A F+++ TG+
Sbjct: 464 PVFTQSFVT--VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGM 521
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y+ +P
Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVP 580
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 581 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE----HSPPGTTVRII 258
V A D + S+ A + I + DV D P+FI +P S YE + PGT V +
Sbjct: 641 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQV 698
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 182/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 136
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 255
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 316 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 366
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 418
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 473 VTVGTSVLTV 482
+ G + V
Sbjct: 479 NSPGIQLTKV 488
Score = 115 bits (289), Expect = 8e-26
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 359 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 474
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+A D D G + Y P + F++D G++TV+++LD E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y+ + E+ P TV +IT
Sbjct: 535 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 648
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEF----NSSEYSVAI--TELAQVGFALPLFIQV 373
S A VT I V+D+NDN P F ++ Y + + T V F QV
Sbjct: 649 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVF------QV 698
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
+ D + G+N+ +VG N+ R +D ET + L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLME 737
Query: 434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-------VSP 486
V D +G +V + + +FS + N+ + E+VT T + ++ V+P
Sbjct: 738 KCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796
Query: 487 RFTAGPLSSPGPTVVR 502
+SSP V+
Sbjct: 797 NTEIADVSSPTSDYVK 812
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 150 bits (379), Expect = 3e-36
Identities = 142/458 (31%), Positives = 212/458 (46%), Gaps = 36/458 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVS---GEEASRFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SVTQL A D D N + F S A R F + TG++ +++PLDR
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDR 317
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + SD + R V + V DVNDN P+ + +V + EN P+
Sbjct: 318 EETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 149 TPIFIVNATDPDLGAGGSV--LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ TD D G V + P + + S + ++ LDYE+T+ Y + +
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLL 437
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A D K PL+ A L I + D D P+F + +I E++ PG + ++A+D D G
Sbjct: 438 AADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 496
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
I Y ++ + F+LD +G+LT+ LDRE ++ T+ L D
Sbjct: 497 PNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREK---EDKYLFTI----LAKDNGVP 548
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T T + +ID NDN+P F +EY+ + E + L I V D D G NS
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPD--YGDNSAV 605
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
+ ++ N I S T V IR I D E + Y F + A + AK
Sbjct: 606 TLSILDENDDFTIDSQTGV-------IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
V I +++ NDN+P+F P N S YE V T+ TV+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCS-YELVLPSTNPGTVV 695
Score = 124 bits (312), Expect = 2e-28
Identities = 89/277 (32%), Positives = 139/277 (50%), Gaps = 15/277 (5%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP--LVFGVSGEEASRFFAVEPDTGV 86
P FT F + I E+ G +T++ A D D+ P + + G +A F+++ TG+
Sbjct: 464 PVFTQSFVT--VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGM 521
Query: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV--ITRKVNIQVG--DVNDNAPTFHNQPYSVRIP 142
+ + + LDRE + ++ D+ GV +T V + V D NDN+P F + Y+ +P
Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDN-GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVP 580
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQ 202
EN P + ++ TDPD G +V S + F IDS G++ D E ++Y
Sbjct: 581 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE----HSPPGTTVRII 258
V A D + S+ A + I + DV D P+FI +P S YE + PGT V +
Sbjct: 641 FYVKAEDGGRV-SRSSSAKVTINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQV 698
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
A+D D G + Y+IV GNT +FA+D +G +TL
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 116 bits (290), Expect = 6e-26
Identities = 112/430 (26%), Positives = 182/430 (42%), Gaps = 45/430 (10%)
Query: 80 VEPDTGVVW----------LRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNA 129
+E DTG ++ L + R+ + VE ++ + K+ + D+NDNA
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNA 136
Query: 130 PTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID-------S 182
P F ++ IPEN+ + + + A DPD+G G Y F +D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
+ V +ELD E Y + V D + ST A L + +TD D P+F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHPVFKETEIE 255
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT---IVSGNTNSIFALDYISGVLTLNGLL 299
+I E++P GT+V + A D D G I ++ +VS +F L+ +G++T+ L
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE +L G + P+ A V + V D+NDN P + + +
Sbjct: 316 DREETPNHKLLVLASDGGLM-----PARAMVL----VNVTDVNDNVPSIDIRYIVNPVND 366
Query: 360 LAQVGFALPL-----FIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
+ +PL I V DKD ++ G + F ++ F + P +
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT-----DHEIPFRLRPVF---SNQFLL 418
Query: 414 RVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
A LDYE+ Y L A ++ P A + I + +ENDN P+F+Q +S+ EN
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 473 VTVGTSVLTV 482
+ G + V
Sbjct: 479 NSPGIQLTKV 488
Score = 115 bits (289), Expect = 8e-26
Identities = 128/496 (25%), Positives = 210/496 (42%), Gaps = 65/496 (13%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
+ N DT +L SE+ P+ + + + D D N + E R V + +
Sbjct: 359 YIVNPVNDTVVL-SENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 87 VWLRQPLDRETKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ LD E+ E+ ++ +D +Q + + I+V D NDNAP F +V
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM---LFIKVKDENDNAPVFTQSFVTVS 474
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQ 199
IPEN G + V+A D D G + Y P + F++D G++TV+++LD E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y T+ A D + PL++ + + I D D P+F + Y+ + E+ P TV +IT
Sbjct: 535 KYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D D G + +I+ N + F +D +GV+ N DRE + VK +
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREK---QESYTFYVKAEDG 648
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEF----NSSEYSVAI--TELAQVGFALPLFIQV 373
S A VT I V+D+NDN P F ++ Y + + T V F QV
Sbjct: 649 GRVSRSSSAKVT----INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVF------QV 698
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
+ D + G+N+ +VG N+ R +D ET + L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNT------------------RDLFAIDQET---GNITLME 737
Query: 434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-------VSP 486
V D +G +V + + +FS + N+ + E+VT T + ++ V+P
Sbjct: 738 KCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796
Query: 487 RFTAGPLSSPGPTVVR 502
+SSP V+
Sbjct: 797 NTEIADVSSPTSDYVK 812
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo
sapiens]
Length = 1955
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TV 482
+
Sbjct: 840 QI 841
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 682 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 742 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 920
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 921 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 977
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1029
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1080
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1081 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 529
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 1012 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1064
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1065 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1242
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1243 VNQLDMQVIVSNVP 1256
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1054 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1170 DKDTGNYSVMAYRLI 1184
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo
sapiens]
Length = 1932
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 368 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 426 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 484 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 544 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 602 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 659 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 711 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 759 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
Query: 481 TV 482
+
Sbjct: 818 QI 819
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 660 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 720 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 898
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 899 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 955
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 956 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1007
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1008 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1058
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1059 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 106 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 286 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 345 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 455
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 456 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 507
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 990 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1042
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1043 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1220
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1221 VNQLDMQVIVSNVP 1234
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 912 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 972 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1031
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1032 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1148 DKDTGNYSVMAYRLI 1162
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 146
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
Length = 1677
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TV 482
+
Sbjct: 840 QI 841
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 682 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 742 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 920
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 921 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 977
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1029
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1080
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1081 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 529
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 1012 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1064
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1065 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1242
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1243 VNQLDMQVIVSNVP 1256
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1054 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1170 DKDTGNYSVMAYRLI 1184
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo
sapiens]
Length = 1682
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 395 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 452
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 453 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 510
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 511 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 570
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 571 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 629 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 685
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 686 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 738 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 785
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 786 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 844
Query: 481 TV 482
+
Sbjct: 845 QI 846
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 687 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 746
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 747 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 806
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 807 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 866
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 867 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 925
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 926 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 982
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 983 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1034
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1035 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1085
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1086 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1141
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1142 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1178
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 133 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 313 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 372 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 428 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 482
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 483 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 534
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 1017 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1069
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1070 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1128
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1129 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1188
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1189 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1247
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1248 VNQLDMQVIVSNVP 1261
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 939 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 998
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 999 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1058
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1059 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1114
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1115 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1174
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1175 DKDTGNYSVMAYRLI 1189
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 135 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 173
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo
sapiens]
Length = 1539
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TV 482
+
Sbjct: 840 QI 841
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 682 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 742 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 920
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 921 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 977
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1029
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1080
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1081 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 529
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 1012 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1064
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1065 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1242
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1243 VNQLDMQVIVSNVP 1256
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1054 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1170 DKDTGNYSVMAYRLI 1184
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo
sapiens]
Length = 1935
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 368 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 426 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 484 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 544 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 602 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 659 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 711 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 759 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
Query: 481 TV 482
+
Sbjct: 818 QI 819
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 660 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 720 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 898
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 899 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 955
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 956 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 1007
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 1008 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1058
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1059 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
Score = 102 bits (253), Expect = 1e-21
Identities = 112/413 (27%), Positives = 174/413 (42%), Gaps = 56/413 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 106 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 286 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 345 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 455
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 456 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 507
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 990 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1042
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1043 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1220
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1221 VNQLDMQVIVSNVP 1234
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 912 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 972 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1031
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1032 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1148 DKDTGNYSVMAYRLI 1162
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 146
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo
sapiens]
Length = 1915
Score = 148 bits (373), Expect = 1e-35
Identities = 137/482 (28%), Positives = 221/482 (45%), Gaps = 55/482 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 353 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 411 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 468
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 469 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 528
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 529 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 587 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 644 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 696 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 743
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 744 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802
Query: 481 TV 482
+
Sbjct: 803 QI 804
Score = 112 bits (280), Expect = 8e-25
Identities = 139/517 (26%), Positives = 219/517 (42%), Gaps = 89/517 (17%)
Query: 37 DTYLLI---SEDTPVGSSVT--QLLAQDMDNDPLVF--------GVSGEEASRFF----A 79
D Y+LI S+ P G+S ++ D++++ VF V EEA+ F A
Sbjct: 645 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 704
Query: 80 VEPDTGV----------------------VWLRQPLDRETKSEFTVEFSVSD---HQGVI 114
+PD G+ ++ L+RE + + + +D H
Sbjct: 705 TDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
Query: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP 174
T + I+V D++DN+P F N Y+V + EN P GT I + A D DLGA S
Sbjct: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 824
Query: 175 SQFFAIDSARGIVTVIRELDYET--TQAYQLT--VNATDQDKTRPLSTLANLAIIITDVQ 230
FFA+ G ++++R LDYE Q +T V A D T P +A + +I+ D+
Sbjct: 825 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMN 883
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTN--------S 282
D P+F Y + + GT + + A D D P G+ + V + S
Sbjct: 884 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPAS 940
Query: 283 IFALDYISG-VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDI 341
IF ++ SG V+T L + + F L V + + S ATV ILV+
Sbjct: 941 IFEVEEDSGRVITRVNLNEEPTTI----FKLVVVAFDDGEPVMSSSATV----KILVLHP 992
Query: 342 NDNAPEFNSSEY-SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFII 400
+ P F EY ++ELA G + + I ++++ VY + + +
Sbjct: 993 GE-IPRFTQEEYRPPPVSELATKGTMVGV-ISAAAINQSI-------VYSIVSGNEEDTF 1043
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFD--------LFANESVPDHVGYAKVKITLIN 452
++ G I V PLDYET Y + AN VP AKV I + +
Sbjct: 1044 GINNITGV----IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1099
Query: 453 ENDNRPIFSQPLYNISLYENVTVGTSVLTVLVSPRFT 489
EN++ P+F + Y + E+ + TSVL V + + T
Sbjct: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1136
Score = 94.7 bits (234), Expect = 2e-19
Identities = 105/394 (26%), Positives = 167/394 (42%), Gaps = 55/394 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
Y Q+ D R + L+ T LTV+ D D P+ +++
Sbjct: 188 EYVI----QYNPDDPDRA-----QNLNERRTTTTTLTVDVLDGDDLGPMFL---PCVLVP 235
Query: 228 DVQDMDPIF-------INLPYSTNIYEHSPPGTTVRIITAIDQDKG------RPRGIGYT 274
+ +D P+ + P N +PP I AIDQD+ RP GI Y+
Sbjct: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPP------IQAIDQDRNIQPPSDRP-GILYS 288
Query: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
I+ G ++ LL+ N + F L +K + N P+ A +
Sbjct: 289 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---- 344
Query: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFAL--------PLFIQVVDKDENLGLNSMF 386
+I ++D N+ +P F Y I E A VG + PL I +DKD +
Sbjct: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKV 446
++L + + F ++ T + + + P+D E Y F + A + V + V
Sbjct: 405 HLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-V 458
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
I +++ NDN P F + Y++ +Y ++ G SV+
Sbjct: 459 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 492
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/254 (24%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 2 GRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD 61
G V +S +LVL G +P FT + +SE G+ V + A ++
Sbjct: 975 GEPVMSSSATVKILVLHPG------EIPRFTQEEYRPPP-VSELATKGTMVGVISAAAIN 1027
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------- 114
+ VSG E F + TGV+++ PLD ET++ + + + V+
Sbjct: 1028 QSIVYSIVSGNEEDTF-GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
Query: 115 ---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF 171
T KV I++ D N++ P F + Y + E+ + T + V ATD D G + Y
Sbjct: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
Query: 172 QPP-----SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIII 226
P + F +++ G++ ++ V ATD D + LS A++ + +
Sbjct: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSV 1205
Query: 227 TDVQDMDPIFINLP 240
+ DM I N+P
Sbjct: 1206 VNQLDMQVIVSNVP 1219
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPL--------VFGVSGEEASRFFAVEPDTGVVWLRQP 92
+++ D G+ +T + A+D D L V V + F VE D+G V R
Sbjct: 897 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 956
Query: 93 LDRETKSEFT-VEFSVSDHQGVITRKVNIQVGDVNDNA-PTFHNQPYSVR-IPENTPVGT 149
L+ E + F V + D + V++ +++ ++ P F + Y + E GT
Sbjct: 957 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1016
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
+ +++A S++YS ++ F I++ G++ V LDYET +Y L V A
Sbjct: 1017 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
Query: 208 TDQD------KTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
+ + S A + I I D + P+F Y + E + T+V + A
Sbjct: 1073 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
Query: 262 DQDKGRPRGIGYTIV 276
D+D G + Y ++
Sbjct: 1133 DKDTGNYSVMAYRLI 1147
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLT 481
Y +V+I + + NDN P F Y ++ E VGT++ T
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,175,881
Number of Sequences: 37866
Number of extensions: 920296
Number of successful extensions: 6822
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1852
Number of HSP's gapped (non-prelim): 1029
length of query: 530
length of database: 18,247,518
effective HSP length: 107
effective length of query: 423
effective length of database: 14,195,856
effective search space: 6004847088
effective search space used: 6004847088
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.