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Search of human proteins with 157384998
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
(1905 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157384998 low density lipoprotein receptor-related protein 4 ... 4047 0.0
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 1121 0.0
gi|148727288 low density lipoprotein receptor-related protein 6 ... 1099 0.0
gi|93102379 low density lipoprotein-related protein 1B precursor... 1080 0.0
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 1065 0.0
gi|119709832 low density lipoprotein receptor-related protein 5 ... 1026 0.0
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 603 e-172
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 602 e-172
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 557 e-158
gi|61744471 low density lipoprotein receptor-related protein 8 i... 550 e-156
gi|65301119 low density lipoprotein receptor-related protein 8 i... 550 e-156
gi|61744467 low density lipoprotein receptor-related protein 8 i... 454 e-127
gi|66082554 low density lipoprotein receptor-related protein 8 i... 413 e-115
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 293 1e-78
gi|4507157 sortilin-related receptor containing LDLR class A rep... 275 2e-73
gi|134031945 SCO-spondin [Homo sapiens] 208 4e-53
gi|32698824 low density lipoprotein receptor-related protein 5-l... 203 1e-51
gi|209447022 low density lipoprotein receptor-related protein 5-... 203 1e-51
gi|115298674 nidogen 1 precursor [Homo sapiens] 203 1e-51
gi|29244926 corin [Homo sapiens] 177 9e-44
gi|144953895 nidogen 2 precursor [Homo sapiens] 174 7e-43
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 141 5e-33
gi|11415040 matriptase [Homo sapiens] 139 3e-32
gi|66346695 fibrillin 2 precursor [Homo sapiens] 117 1e-25
gi|28557796 low density lipoprotein receptor class A domain cont... 115 5e-25
gi|24430141 fibrillin 1 precursor [Homo sapiens] 110 1e-23
gi|56237021 fibrillin 3 precursor [Homo sapiens] 108 5e-23
gi|208973262 low density lipoprotein-related protein 12 isoform ... 108 7e-23
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 108 7e-23
gi|46249414 latent transforming growth factor beta binding prote... 107 1e-22
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 4047 bits (10495), Expect = 0.0
Identities = 1905/1905 (100%), Positives = 1905/1905 (100%)
Query: 1 MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH
Sbjct: 1 MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60
Query: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG 120
SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG
Sbjct: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG 120
Query: 121 YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE 180
YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
Sbjct: 121 YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE 180
Query: 181 NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS 240
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS
Sbjct: 181 NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS 240
Query: 241 GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD 300
GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD
Sbjct: 241 GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD 300
Query: 301 EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV 360
EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
Sbjct: 301 EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV 360
Query: 361 NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC 420
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC
Sbjct: 361 NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC 420
Query: 421 ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE 480
ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE
Sbjct: 421 ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE 480
Query: 481 LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL 540
LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
Sbjct: 481 LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL 540
Query: 541 DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP 600
DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP
Sbjct: 541 DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP 600
Query: 601 NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT 660
NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT
Sbjct: 601 NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT 660
Query: 661 KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY 720
KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY
Sbjct: 661 KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY 720
Query: 721 TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW 780
TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW
Sbjct: 721 TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW 780
Query: 781 DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI 840
DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI
Sbjct: 781 DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI 840
Query: 841 EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS 900
EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS
Sbjct: 841 EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS 900
Query: 901 NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW 960
NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW
Sbjct: 901 NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW 960
Query: 961 TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS 1020
TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS
Sbjct: 961 TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS 1020
Query: 1021 PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM 1080
PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM
Sbjct: 1021 PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM 1080
Query: 1081 KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW 1140
KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW
Sbjct: 1081 KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW 1140
Query: 1141 TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS 1200
TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS
Sbjct: 1141 TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS 1200
Query: 1201 DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL 1260
DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL
Sbjct: 1201 DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL 1260
Query: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC 1320
LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
Sbjct: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC 1320
Query: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP 1380
SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP
Sbjct: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP 1380
Query: 1381 VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR 1440
VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR
Sbjct: 1381 VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR 1440
Query: 1441 NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN 1500
NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN
Sbjct: 1441 NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN 1500
Query: 1501 LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF 1560
LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF
Sbjct: 1501 LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF 1560
Query: 1561 ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN 1620
ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN
Sbjct: 1561 ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN 1620
Query: 1621 NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY 1680
NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY
Sbjct: 1621 NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY 1680
Query: 1681 SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV 1740
SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV
Sbjct: 1681 SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV 1740
Query: 1741 IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH 1800
IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH
Sbjct: 1741 IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH 1800
Query: 1801 NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT 1860
NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT
Sbjct: 1801 NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT 1860
Query: 1861 ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV 1905
ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
Sbjct: 1861 ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV 1905
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 1121 bits (2899), Expect = 0.0
Identities = 639/1692 (37%), Positives = 946/1692 (55%), Gaps = 113/1692 (6%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG--CILPTCSPLDFHCDN 80
P+C G F CA S CI +W+CDGDNDC D+SDE C TC F C+N
Sbjct: 852 PQCQPGE--FACANSR-----CIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCEN 904
Query: 81 GKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDN 138
+CI W+CDGDNDC + DE + C R C ++F C +G CI W CD D+DCGD
Sbjct: 905 NRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDR 964
Query: 139 SDEQ--CDMRKCSD-KEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEE 195
SDE C C +F C++G CI +W CD D DC D SDE C + C+ +
Sbjct: 965 SDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHS-----CSSTQ 1019
Query: 196 FQCAYGRCILDIYHCDGDDDCGDWSDES--DCSSHQP-----CRSGEFMCD-SGLCINAG 247
F+C GRCI + + CDGD+DCGD+SDE+ +C++ C + EF C GLCI
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
Query: 248 WRCDGDADCDDQSDERNC--TTSMCTAE-QFRCH-SGRCVRLSWRCDGEDDCADNSDEEN 303
WRCDGD DC D SDE++C T +C +F C S RC+ +W CDG++DC DNSDEEN
Sbjct: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
Query: 304 CENTGSPQCALDQFLCWNGR--CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
CE+ C C N C+ KLC+G +DCGD SDE + C + C++N
Sbjct: 1140 CESLA---CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG--ELC------DQCSLN 1188
Query: 362 NGGCAQKCQMVRG-AVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC 420
NGGC+ C + G + C+C G L D HTCQ + CA+ CSQ C ++ + +C C
Sbjct: 1189 NGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSC 1248
Query: 421 ETGYELRPDRRSCKALGP-EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRR 479
G+ L PD SC++L P +P ++F+NR +IR++ H+ +Y++L+ L N IALDFH +
Sbjct: 1249 YEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQ 1308
Query: 480 ELVFWSDVTLDRILRANL--NGS--NVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRI 535
++W+DV D+I R L NG+ + E V+ GL +P GLAVDW+ +YW +S +I
Sbjct: 1309 SALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQI 1368
Query: 536 EVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW-GNTPRIEASSMDGSGRRII-- 592
EVA LDG R LL ++E PRAIAL P +G ++WTDW + PRIEA+SM G+GRR +
Sbjct: 1369 EVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHR 1428
Query: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFE 650
WPNGLT+DY +R+ W+DA+ I A DGS V+ + L HPFA+T++
Sbjct: 1429 ETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYG 1488
Query: 651 DSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN--NGG 708
+YWTDW T ++ ANK+TG N +++ P D+ HP RQP N C N G
Sbjct: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548
Query: 709 CTHLCLPS-GQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDV- 766
C+HLCL + + +CACP + + KFLL+AR+M+IR + D + +
Sbjct: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIIS 1608
Query: 767 IPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWV 826
+ D+ + LD+D+R+ VYW+DV T I RA +GTG E VV L + GLA+DWV
Sbjct: 1609 FTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWV 1668
Query: 827 TNKLYWT--DAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKI 884
+ L+WT D +I VA DGS + ++ + L++P +VV P+ G +YWTD I
Sbjct: 1669 SRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD---GDNI 1724
Query: 885 ERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVL--IG 942
A MD S R ++ S P GLAID+ +LYW +G TI LDGS +V+ +
Sbjct: 1725 SMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMR 1783
Query: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH---RRR 999
SQL L + G++++W D ++ + + + G L+ + +M + V+ +
Sbjct: 1784 SQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLD 1843
Query: 1000 PPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDI 1059
+ PC++ NG CS LCL + + SC C G +L S + C G+ SFL+++ I
Sbjct: 1844 HKGTNPCSVNNGDCSQLCLPTSETTR-SCMCTAGYSLRSGQQACE-GVGSFLLYSVHEGI 1901
Query: 1060 RMVSLDIPYFADVVVPINITMKNTIAIGVD--PQEGKVYWSDSTLHRISRANLDGSQHED 1117
R + LD +D +VP++ T ++A+G+D + +YW D L ISRA D + ED
Sbjct: 1902 RGIPLDPNDKSDALVPVSGT---SLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED 1958
Query: 1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHE 1177
++T G+ +G+AVD I +YWTD G + IEV L+GS R V++ Q LD PRAI ++ E
Sbjct: 1959 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPE 2018
Query: 1178 MGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEA 1237
G+++WT+WG+ ++ERS +DG++R VL+N ++ WPNG++VD +L W DA T++IE
Sbjct: 2019 KGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIER 2078
Query: 1238 ADL-NGANRHTLVSP-VQHPYGLTLLDSYIYWTD--WQTRSIHRADKGTGSNVILVRSNL 1293
DL G NR ++S + +++ + +IYW+D SI R K ++ + +R+ +
Sbjct: 2079 IDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
Query: 1294 -PGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG-FSCACPTGIQLKGDGKTCDPS 1351
L D++ +R + G N C NGGC LCL R G +CAC G+ L DG +C
Sbjct: 2139 GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGM-LAEDGASC-RE 2196
Query: 1352 PETYLLFSSRGSIRRISLDTSDHTDVHVPV-----PE-LNNVISLDYD-------SVDGK 1398
YLL+S R ++ I L SD +++ PV PE + NVI+L +D +
Sbjct: 2197 YAGYLLYSERTILKSIHL--SDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNR 2254
Query: 1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTD-----TGRNTIE 1453
++++D+ I++ + +GS T++ + + +GLA LYWT R+T++
Sbjct: 2255 IFFSDIHFGNIQQINDDGSRRITIV-ENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
Query: 1454 ASRLDGSCRKVLINNSLDE-PRAIAVFPRKGYLFWTDWG-HIAKIERANLDGSERKVLIN 1511
+R R+ +I S D+ PRA + + +FWT+W I RA L G+ LI
Sbjct: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
Query: 1512 TDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIY 1570
D+ PNGL +D+ ++Y+ DA LD+IE + +G R V++ S HPF L I+
Sbjct: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433
Query: 1571 WTDWQTKSIQRVDKYSGRNKETVLANV--EGLMDIIVVSPQRQTGTNACGVNNGGCTHLC 1628
WTDW +++QR +K+ G N + + ++ + + I V + + C +NNGGC LC
Sbjct: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLC 2493
Query: 1629 FARASDFV-CAC 1639
V C+C
Sbjct: 2494 LLTHQGHVNCSC 2505
Score = 617 bits (1590), Expect = e-176
Identities = 332/756 (43%), Positives = 428/756 (56%), Gaps = 59/756 (7%)
Query: 11 GALLCAHGLASSP--ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL 68
GA C G P + ACG F C + TCI +C+ DC D SDE C
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVGEFRCR-----DGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
Query: 69 PTCSP---------LDFHCDNGK-CIRRSWVCDGDNDCEDDSDEQDCP----PRECEEDE 114
CS L C+ C SWVCDG NDC D SDE+DCP PR C +
Sbjct: 2642 TDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR-CPLNY 2700
Query: 115 FPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCK 174
F C +G CI W CD ++DC DE + CS+ +F C + CI++ W CDG DC
Sbjct: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
Query: 175 DGSDEENCPSAVPAPPCNLEEFQCAYGR-CILDIYHCDGDDDCGDWSDES---DCSSHQP 230
DGSDE + C F C C+ + + CDGD DC D +DES C +
Sbjct: 2761 DGSDEA---AHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 2817
Query: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDER-NCTTSMCTAEQFRCHSGRCVRL-SWR 288
C EFMC + CI + CD D DC D SDE C C +FRC +GRC+ W
Sbjct: 2818 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWE 2877
Query: 289 CDGEDDCADNSDEE----NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDES 344
CDGE+DC D SDE +C + A QFLC +GRC+ + LCNG +DCGD+SDE
Sbjct: 2878 CDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE- 2936
Query: 345 PQQNCRPRTGEENCNVNN------GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNE 398
C++N GC+Q C+ ++ +C C G+RL +DG TC DV+E
Sbjct: 2937 -----------RGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDE 2985
Query: 399 CAEEGYCSQGCTNSEGAFQCWCETGYELRP-DRRSCKAL-GPEPVLLFANRIDIRQVLPH 456
C+ CSQ C N+ G+++C C GY R D SCKA+ EP L+FANR +R++
Sbjct: 2986 CSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLD 3045
Query: 457 RSEYTLLLNNLENAIALDFHHRRELVFWSDVTLD--RILRANLNGSNVEEVVSTGLESPG 514
S YTLL L NA+ALDF +R ++++W+DVT I R +LNGSNV+ + TGL +P
Sbjct: 3046 GSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPD 3105
Query: 515 GLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG 574
GLAVDWV LYW D G IEV+ L+GA+R VL+ L +PRA+ + G +YWTDWG
Sbjct: 3106 GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWG 3165
Query: 575 NTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKA 634
+ I MDGS R +I DT + WPNGLT+DY R+YW DA+ IE A+LDGS+R
Sbjct: 3166 DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHV 3225
Query: 635 VISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQR 694
V+SQ +PH FA+T+FED +YWTDW TKSIN A+K TG N+ ++ + LH PMD+H H R
Sbjct: 3226 VLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALR 3285
Query: 695 QPAGKNR-CGDNNGGCTHLCLPS-GQNYTCACPTGF 728
QP N C NNGGC++LCL S G + CACPT F
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNF 3321
Score = 538 bits (1385), Expect = e-152
Identities = 329/980 (33%), Positives = 518/980 (52%), Gaps = 48/980 (4%)
Query: 402 EGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEY 460
+G CS C N C C +L D +C + LL+A +++IR V Y
Sbjct: 1546 QGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF--KKFLLYARQMEIRGVDLDAPYY 1603
Query: 461 TLLLN----NLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGL 516
+++ +++N LD+ R + V+WSDV I RA +NG+ VE VVS L + GL
Sbjct: 1604 NYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGL 1663
Query: 517 AVDWVHDKLYWT--DSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG 574
AVDWV L+WT D+ +I VA LDG+ + ++ Q LE+P + +HP+ G +YWTD
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDGD 1722
Query: 575 NTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKA 634
N I ++MDGS R ++ P GL ID+ ++YW+ + +H I R NLDGS +
Sbjct: 1723 N---ISMANMDGSNRTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778
Query: 635 V--ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNK--LHFPMDIHTL 690
+ + L A+ + D L+W D ++ + + +K G ++RN L M ++
Sbjct: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838
Query: 691 HPQRQPAGKNRCGDNNGGCTHLCLPSGQNY-TCACPTGFRKISSHACAQSLDKFLLFARR 749
Q G N C NNG C+ LCLP+ + +C C G+ S + + FLL++
Sbjct: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVH 1898
Query: 750 MDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEV 809
IR I D D SD ++P++ AV +D+ + +D +YW D+ TISRAK D T +E
Sbjct: 1899 EGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED 1958
Query: 810 VVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPM 869
VV + G+A+DW+ +YWTD G D IEVA +GS R V+I + LD+PR I V P
Sbjct: 1959 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPE 2018
Query: 870 GGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEF 929
GY++WT+WG P+IER+ +D + R V+++ +++WPNG+++DY +LYW DA IE
Sbjct: 2019 KGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIER 2078
Query: 930 AGLD-GSKRKVLIGSQLPHPFGLTLYGERIYWTD--WQTKSIQSADRLTGLDRETLQENL 986
L+ G R+V++ S F ++++ + IYW+D SI+ + D L+ +
Sbjct: 2079 IDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
Query: 987 E-NLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSP 1045
L DI VF+R R + CA+ NGGC LCL +C C G+ L DG +C
Sbjct: 2139 GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQR-ACACAHGM-LAEDGASCRE 2196
Query: 1046 GMNSFLIFARRIDIRMVSL-DIPYFADVVVPINIT--MKNTIAIGVDPQEG-------KV 1095
+L+++ R ++ + L D V P MKN IA+ D + G ++
Sbjct: 2197 -YAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRI 2255
Query: 1096 YWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLD- 1154
++SD I + N DGS+ I+ + + +GLA +YWT T+ I +D
Sbjct: 2256 FFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQ 2314
Query: 1155 ---GSMRK--VLVWQNLDSPRAIVLYHEMGFMYWTDWGE-NAKLERSGMDGSDRAVLINN 1208
G+ + V+ D PRA VL M+WT+W E + + R+ + G++ LI
Sbjct: 2315 TRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEK 2374
Query: 1209 NLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYW 1267
++ PNGL +D + +L ++DA ++IE + +G++R+ ++ S HP+GL + +I+W
Sbjct: 2375 DIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 2434
Query: 1268 TDWQTRSIHRADKGTGSNVILVRSNLPGL-MDMQAV-DRAQPLGFNKCGSRNGGCSHLCL 1325
TDW R++ RA+K GSN+ L+R ++P M + AV + + C NGGC LCL
Sbjct: 2435 TDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCL 2494
Query: 1326 PRPSG-FSCACPTGIQLKGD 1344
G +C+C G L+ D
Sbjct: 2495 LTHQGHVNCSCRGGRILQDD 2514
Score = 521 bits (1343), Expect = e-147
Identities = 286/744 (38%), Positives = 392/744 (52%), Gaps = 53/744 (7%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG-CILPTCSPLDFHC-DN 80
PE C + F C+++ CIP W CD DNDC D SDE C TC +F C D+
Sbjct: 3449 PEVTCAPNQFQCSITK----RCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDS 3504
Query: 81 GKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDN 138
G+CI W CDG++DC D SDE ++C R CE +F C+N C+ W CD DNDCGDN
Sbjct: 3505 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDN 3564
Query: 139 SDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQ 197
SDE+ C R CS+ EF C++G CIA W CDGD DC DGSDE++C P C++++FQ
Sbjct: 3565 SDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC-----TPRCDMDQFQ 3619
Query: 198 CAYGRCILDIYHCDGDDDCGDWSDESDCSSH-QPCRSGEFMCDSGLCINAGWRCDGDADC 256
C G CI + CD D DC D SDE C + + C EF C++ LC W+CDG+ DC
Sbjct: 3620 CKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDC 3679
Query: 257 DDQSDER--NCTTSMCTAEQ-FRCHSGR-CVRLSWRCDGEDDCADNSDEENCE--NTGSP 310
D SDE C +C + FRC + R C+ + +CDG D+C D +DEE+CE +
Sbjct: 3680 GDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTT 3739
Query: 311 QCA-LDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKC 369
C +FLC N RC+ CN +DCGD SDE ++C +C N C +
Sbjct: 3740 HCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE---EDCSIDPKLTSCATNASICGDEA 3796
Query: 370 QMVRG--AVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELR 427
+ VR A C C +G+ CQD+NEC G CSQ C N++G C C +
Sbjct: 3797 RCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNF--M 3854
Query: 428 PDRRSCKALGPE-PVLLFANRIDIRQVLPHR--SEYTLLLNNLENAI--ALDFHHRRELV 482
+CKA G E VL A+ +IR + P S Y E+ A+D H + V
Sbjct: 3855 KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRV 3914
Query: 483 FWSDVTLDRI-----------LRANLNGSNVEEVVS----TGLESPGGLAVDWVHDKLYW 527
+W++ I +N + ++ V+ +GL+ P G+A+DWV +YW
Sbjct: 3915 YWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYW 3974
Query: 528 TDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGS 587
TDSG IEVA + G +RK L+ +++P AI + P+ GT+YW+DWGN P+IE ++MDG+
Sbjct: 3975 TDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGT 4034
Query: 588 GRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR--KAVISQGLPHPFA 645
R + ++ WP GL +DY R+YW DAK VI L+G+ A +GL HPF+
Sbjct: 4035 LRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFS 4094
Query: 646 ITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN 705
I VFED +Y + + +KF + L D+ H +QP N C +
Sbjct: 4095 IDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--D 4152
Query: 706 NGGCTHLCLPSGQNYTCACPTGFR 729
C LCL S C CP G R
Sbjct: 4153 RKKCEWLCLLSPSGPVCTCPNGKR 4176
Score = 438 bits (1127), Expect = e-122
Identities = 276/827 (33%), Positives = 425/827 (51%), Gaps = 64/827 (7%)
Query: 270 CTAEQFRCHSG-RCVRLSWRCDGEDDCADNSDE--ENCENTGSPQCALDQFLCWNGR-CI 325
C+ +QF C C+ WRCDGE DC D SDE E C + + +C ++ C C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 326 GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYR 385
+LCNGV DC D SDE P +CR G N + GC C C C++ ++
Sbjct: 87 PMSRLCNGVQDCMDGSDEGP--HCRELQG----NCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
Query: 386 LTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKA----LGPEPV 441
L DG TC+D +EC+ G CSQ CTN++G+F C C GY L+PD RSCKA + PV
Sbjct: 141 LQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV 200
Query: 442 LLFANRIDIRQV-LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGS 500
LL AN +I L T+ + A+DF + E V W V D + L +
Sbjct: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVG-DSAAQTQLKCA 259
Query: 501 NVEEV----------VSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLW 550
+ + +S L +A+DW+ Y+ D RI V N +G LL
Sbjct: 260 RMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLD 319
Query: 551 QNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610
L P+ IAL P G +++TD+G P++E MDG R + D+ + +P+G+T+D R
Sbjct: 320 LELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSR 379
Query: 611 RMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYWTD------WHTKS 662
+YW DA IE + +G R+ +I QG + H + +TVFE+ LY T+ S
Sbjct: 380 LVYWADAYLDYIEVVDYEGKGRQTII-QGILIEHLYGLTVFENYLYATNSDNANAQQKTS 438
Query: 663 INSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNN-----GGCTHLCL--P 715
+ N+F +++ ++ +H H +RQP ++ +N+ GGC+ +CL
Sbjct: 439 VIRVNRFNSTEYQVV-TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLAN 497
Query: 716 SGQNYTCACPTGFRKIS-SHACAQ-SLDKFLLFARRMD--IRRISFDTEDLSDDVIPLAD 771
S + TC C +GF S +C + + FL++ + IR + + + +IP+ +
Sbjct: 498 SHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIEN 557
Query: 772 VRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLY 831
+ + ALD+ + +Y+ D ++ I R K DGT +E ++ + + G+A+DW+ + LY
Sbjct: 558 LMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLY 617
Query: 832 WTDAGTDR-IEVANTDGSMRT--VLIWENLDRPRDIVVEPMGGYMYWTDWGASPK----- 883
WTD G + I VA + + +T LI + PR IVV+P+ G+MYWTDW PK
Sbjct: 618 WTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRG 677
Query: 884 -IERAGMDASGRQVIISS-NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI 941
+ERA MD S R + ++S + WPNGL++D + RLYW DA IE L+G+ RK++
Sbjct: 678 RLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVY 737
Query: 942 -GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRET---LQENLENLMDIHVFHR 997
G +L H FGL +G ++WT++++ S+ +R G T L+ + +I ++
Sbjct: 738 EGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDA 797
Query: 998 RRPPVST-PCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
++ V T C + NGGCS LCL +P C C L +DG TC
Sbjct: 798 QQQQVGTNKCRVNNGGCSSLCLATPGSR--QCACAEDQVLDADGVTC 842
Score = 366 bits (940), Expect = e-100
Identities = 225/677 (33%), Positives = 363/677 (53%), Gaps = 37/677 (5%)
Query: 397 NECA-EEGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL 454
N C+ G CSQ C SE C C GY LR +++C+ +G LL++ IR +
Sbjct: 1848 NPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIP 1905
Query: 455 ---PHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLE 511
+S+ + ++ A+ +DFH + ++W D+ L I RA + + E+VV+ G+
Sbjct: 1906 LDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIG 1965
Query: 512 SPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWT 571
G+AVDW+ +YWTD G IEVA L+G+ R V++ Q L+KPRAI +HP +G ++WT
Sbjct: 1966 RVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWT 2025
Query: 572 DWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLD-GS 630
+WG PRIE S +DG+ R ++ + + WPNG+++DY ++YW DA+ IER +L+ G
Sbjct: 2026 EWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGE 2085
Query: 631 HRKAVISQGLPHPFAITVFEDSLYWTD-WHTK-SINSANKFTGKNQEIIRNKLHFPM-DI 687
+R+ V+S F+++VFED +YW+D H SI +K + +R + + DI
Sbjct: 2086 NREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDI 2145
Query: 688 HTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY-TCACPTGFRKISSHACAQSLDKFLLF 746
+ RQ G N C NGGC LCL G+ CAC G +C + +LL+
Sbjct: 2146 KVFNRDRQ-KGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAG-YLLY 2203
Query: 747 ARRMDIRRISF-DTEDLSDDVIPLAD---VRSAVALDWDSR-------DDHVYWTDVSTD 795
+ R ++ I D +L+ V P D +++ +AL +D R + ++++D+
Sbjct: 2204 SERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFG 2263
Query: 796 TISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGS------M 849
I + DG+ + +V+ ++ S GLA + LYWT T I D +
Sbjct: 2264 NIQQINDDGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 2322
Query: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLTWPNGL 908
TV+ D PR V++ M+WT+W P I RA + + +I ++ PNGL
Sbjct: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGL 2382
Query: 909 AIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSI 968
AID+ +++LY++DA + IE DGS R V++ S+ HPFGL +YGE I+WTDW +++
Sbjct: 2383 AIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAV 2442
Query: 969 QSADRLTGLDRETLQENL--ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
Q A++ G + + L+ ++ + + I V + +PC + NGGC LCL + +
Sbjct: 2443 QRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLT-HQGHV 2501
Query: 1027 SCTCPTGINLLSDGKTC 1043
+C+C G +L D TC
Sbjct: 2502 NCSCRGG-RILQDDLTC 2517
Score = 339 bits (870), Expect = 1e-92
Identities = 218/692 (31%), Positives = 349/692 (50%), Gaps = 49/692 (7%)
Query: 707 GGCTHLCLPSGQNYTCACPTGFR----KISSHACAQSLDK--FLLFARRMDIRRISFDTE 760
G C+ LC + ++ C C G+ S A + +D+ LL A +I
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
Query: 761 DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDT----ISRAKWDGTG-----QEVVV 811
+S I R A+D+ ++ V W V + A+ G + +
Sbjct: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 812 DTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGG 871
SL +AIDW+T Y+ D DRI V N +G L+ L P+ I ++P G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 872 YMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAG 931
+++TD+G PK+ER MD R ++ S + +P+G+ +D S+ +YWADA + IE
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 932 LDGSKRKVLI-GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQE-----N 985
+G R+ +I G + H +GLT++ +Y T+ + Q + ++R E
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
Query: 986 LENLMDIHVFHRRRPPVSTPCAMEN------GGCSHLCLRSPNPSGFSCTCPTGINLLSD 1039
++ +H++H+RR P A EN GGCS +CL + + +C C +G +L SD
Sbjct: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
Query: 1040 GKTC-SPGMNSFLIF--ARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVY 1096
GK+C P FL++ R IR + + + ++PI + N A+ + G +Y
Sbjct: 516 GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIE-NLMNPRALDFHAETGFIY 574
Query: 1097 WSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNR-IEVGNLD- 1154
++D+T + I R +DG++ E I+ G+ +G+AVD +G +YWTD G + I V L+
Sbjct: 575 FADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEK 634
Query: 1155 -GSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAK------LERSGMDGSDRAVLI- 1206
RK L+ + PRAIV+ G+MYWTDW E+ K LER+ MDGS R + +
Sbjct: 635 AAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT 694
Query: 1207 NNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVS--PVQHPYGLTLLDSY 1264
+ + WPNGL++D + +L W DA +RIE LNG +R + + H +GL +Y
Sbjct: 695 SKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNY 754
Query: 1265 IYWTDWQTRSIHRADKGTGS---NVILVRSNLPGLMDMQAVD-RAQPLGFNKCGSRNGGC 1320
++WT++++ S++R ++G G V L+RS P + +++ D + Q +G NKC NGGC
Sbjct: 755 LFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGC 814
Query: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSP 1352
S LCL P CAC L DG TC +P
Sbjct: 815 SSLCLATPGSRQCACAEDQVLDADGVTCLANP 846
Score = 319 bits (818), Expect = 1e-86
Identities = 215/699 (30%), Positives = 344/699 (49%), Gaps = 57/699 (8%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF-----LIFARRIDIRMVSLD 1065
G CS LC + F C C G L D ++C L+ A +I L
Sbjct: 158 GTCSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215
Query: 1066 IPYFADVVVPINITMKNTIAIGVDPQEGKVYW---SDSTLH-RISRANLDG-----SQHE 1116
A V + + T A+ V W DS ++ A + G +H
Sbjct: 216 ---GAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHT 272
Query: 1117 DIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
I+ L + +A+D + Y+ D +RI V N +G L+ L +P+ I L
Sbjct: 273 INISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDP 332
Query: 1177 EMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIE 1236
MG +++TD+G+ K+ER MDG +R L+++ + +P+G+T+D S + WADA+ + IE
Sbjct: 333 AMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIE 392
Query: 1237 AADLNGANRHTLVSPV--QHPYGLTLLDSYIYWTD------WQTRSIHRADKGTGSNV-I 1287
D G R T++ + +H YGLT+ ++Y+Y T+ Q S+ R ++ + +
Sbjct: 393 VVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQV 452
Query: 1288 LVRSNLPGLMDMQAVDRAQPLGFNKCGS----RNGGCSHLCLPRPS--GFSCACPTGIQL 1341
+ R + G + + R + + C + + GGCS +CL S +C C +G L
Sbjct: 453 VTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSL 512
Query: 1342 KGDGKTCD-PSPETYLLFSSR--GSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGK 1398
DGK+C P E +L++ G IR + + + +P+ L N +LD+ + G
Sbjct: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
Query: 1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG-RNTIEASRL 1457
+Y+ D +I R ++G+ ET++ G+ +G+AVDW+ NLYWTD G + TI +RL
Sbjct: 573 IYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARL 632
Query: 1458 D--GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDW------GHIAKIERANLDGSERKVL 1509
+ RK LI + PRAI V P G+++WTDW ++ERA +DGS R +
Sbjct: 633 EKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF 692
Query: 1510 INT-DLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQD 1566
+ + + WPNGL+LD R+YWVDA DRIE+ LNG R+++ ++H F L
Sbjct: 693 VTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHG 752
Query: 1567 RWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVV----SPQRQTGTNACGVNNG 1622
+++WT++++ S+ R+++ G TV I + + Q+Q GTN C VNNG
Sbjct: 753 NYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNG 812
Query: 1623 GCTHLCFARASDFVCACPD----EPDSRPCSLVPGLVPP 1657
GC+ LC A CAC + + D C P VPP
Sbjct: 813 GCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPP 851
Score = 307 bits (787), Expect = 6e-83
Identities = 155/343 (45%), Positives = 210/343 (61%), Gaps = 12/343 (3%)
Query: 709 CTHLCLPSGQNYTCACPTGF--RKISSHACAQSLDK--FLLFARRMDIRRISFDTEDLSD 764
C+ C+ + +Y C C G+ R H+C D+ FL+FA R +R+++ D S+
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDG---SN 3048
Query: 765 DVIPLADVRSAVALDWDSRDDHVYWTDVSTD--TISRAKWDGTGQEVVVDTSLESPAGLA 822
+ + +AVALD+D R+ +YWTDV+T I R +G+ +V+ T L +P GLA
Sbjct: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 823 IDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASP 882
+DWV LYW D G D IEV+ +G+ RTVL+ L PR +VV+ GY+YWTDWG
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
Query: 883 KIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIG 942
I R GMD S R VI+ + +TWPNGL +DY ++R+YWADA IEFA LDGS R V++
Sbjct: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
Query: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPP- 1001
+PH F LTL+ + +YWTDW+TKSI A + TG ++ L L MD+HVFH R P
Sbjct: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
Query: 1002 -VSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
+ PC + NGGCS+LCL SP G C CPT L SDG+TC
Sbjct: 3289 VPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRTC 3330
Score = 282 bits (721), Expect = 3e-75
Identities = 161/392 (41%), Positives = 219/392 (55%), Gaps = 57/392 (14%)
Query: 1311 NKCGSRN-GGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--------------------- 1348
N+C SR GCS C GF C C G +LK DG+TC
Sbjct: 2942 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHG 3001
Query: 1349 ---------------DP-------SPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
DP E +L+F++R +R+++LD S++T + LNN
Sbjct: 3002 SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLK---QGLNN 3058
Query: 1387 VISLDYDSVDGKVYYTDVFLD--VIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYW 1444
++LD+D + +Y+TDV +IRR LNGSN++ + GL DGLAVDWV NLYW
Sbjct: 3059 AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYW 3118
Query: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
D GR+TIE S+L+G+ R VL+++ L EPRA+ V + GYL+WTDWG + I R +DGS
Sbjct: 3119 CDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGS 3178
Query: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSH-VSHPFALT 1563
R V+++T + WPNGLTLDY T RIYW DA D IE A L+G R V++S + H FALT
Sbjct: 3179 SRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALT 3238
Query: 1564 QQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVNN 1621
+ ++YWTDW+TKSI R K +G NK +++ + MD+ V RQ + C VNN
Sbjct: 3239 LFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNN 3298
Query: 1622 GGCTHLC-FARASDFVCACPDE----PDSRPC 1648
GGC++LC + CACP D R C
Sbjct: 3299 GGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC 3330
Score = 258 bits (658), Expect = 5e-68
Identities = 142/354 (40%), Positives = 204/354 (57%), Gaps = 20/354 (5%)
Query: 1001 PVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIR 1060
P S C +G LC+ P G P ++D + FLIFA R +R
Sbjct: 2991 PCSQRCINTHGSYKCLCVEGYAPRGGD---PHSCKAVTDEEP-------FLIFANRYYLR 3040
Query: 1061 MVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLH--RISRANLDGSQHEDI 1118
++LD + + +N N +A+ D +E +YW+D T I R +L+GS + +
Sbjct: 3041 KLNLDGSNYTLLKQGLN----NAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVL 3096
Query: 1119 ITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM 1178
TGL DGLAVD +G +YW D G + IEV L+G+ R VLV L PRA+V+ +
Sbjct: 3097 HRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQN 3156
Query: 1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
G++YWTDWG+++ + R GMDGS R+V+++ + WPNGLT+D + ++ WADA + IE A
Sbjct: 3157 GYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFA 3216
Query: 1239 DLNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLM 1297
L+G+NRH ++S + H + LTL + Y+YWTDW+T+SI+RA K TG+N L+ S L M
Sbjct: 3217 SLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPM 3276
Query: 1298 DMQAVD--RAQPLGFNKCGSRNGGCSHLCLPRP-SGFSCACPTGIQLKGDGKTC 1348
D+ R + + C NGGCS+LCL P G CACPT L DG+TC
Sbjct: 3277 DLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC 3330
Score = 189 bits (480), Expect = 2e-47
Identities = 123/379 (32%), Positives = 182/379 (48%), Gaps = 43/379 (11%)
Query: 698 GKNRCGDNN-----GGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLF-ARRMD 751
G+ C D N G C+ LC + + C+C F K + A+ + +L+ A +
Sbjct: 3818 GQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNE 3877
Query: 752 IRRI-------SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG 804
IR + +++ D+ + + A+D + VYWT+ T TIS
Sbjct: 3878 IRSLFPGHPHSAYEQAFQGDESVRID------AMDVHVKAGRVYWTNWHTGTISYRSLPP 3931
Query: 805 TGQEVVVD---------------TSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSM 849
+ + L+ P G+AIDWV +YWTD+G D IEVA G
Sbjct: 3932 AAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGEN 3991
Query: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLA 909
R LI +D P IVV+P+ G MYW+DWG PKIE A MD + R+ ++ N+ WP GLA
Sbjct: 3992 RKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLA 4051
Query: 910 IDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKS 967
+DY ++RLYWADA + I L+G+ V S+ L HPF + ++ + IY +
Sbjct: 4052 VDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNR 4111
Query: 968 IQSADRLTGLDRETLQENLENLMDIHVFHR-RRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
+ + L L + D+ ++H+ ++P V+ PC + C LCL S PSG
Sbjct: 4112 VFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLS--PSGP 4167
Query: 1027 SCTCPTGINLLSDGKTCSP 1045
CTCP G L D TC P
Sbjct: 4168 VCTCPNGKRL--DNGTCVP 4184
Score = 173 bits (438), Expect = 2e-42
Identities = 121/366 (33%), Positives = 156/366 (42%), Gaps = 80/366 (21%)
Query: 102 EQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGD------NSDEQCDMRKCSDKEFRC 155
+ D P C+ + C N C+ S G + C SD + + C+ +F C
Sbjct: 3286 QPDVPNHPCKVNNGGCSN-LCLLSP---GGGHKCACPTNFYLGSDGRTCVSNCTASQFVC 3341
Query: 156 SDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDD 215
+ CI W CD + DC D SDE P P C +FQC+ G C + CDGD+D
Sbjct: 3342 KNDKCIPFWWKCDTEDDCGDHSDE---PPDCPEFKCRPGQFQCSTGICTNPAFICDGDND 3398
Query: 216 CGDWSDESDCSSH------------QPCRSGEFMCD------------------------ 239
C D SDE++C H C G F C+
Sbjct: 3399 CQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQF 3458
Query: 240 ----SGLCINAGWRCDGDADCDDQSDE-RNCTTSMCTAEQFRC-HSGRCVRLSWRCDGED 293
+ CI W CD D DC D SDE NCT C ++FRC SGRC+ W+CDGED
Sbjct: 3459 QCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGED 3518
Query: 294 DCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPR- 352
DC D SDE E C QF C N RC+ R C+ NDCGDNSDE ++C PR
Sbjct: 3519 DCGDGSDEPK-EECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDE---ESCTPRP 3574
Query: 353 TGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNS 412
E + NG C + G +C + H C D ++E C+ C
Sbjct: 3575 CSESEFSCANGRC------IAGRWKC---------DGDHDCAD---GSDEKDCTPRCDMD 3616
Query: 413 EGAFQC 418
+ FQC
Sbjct: 3617 Q--FQC 3620
Score = 173 bits (438), Expect = 2e-42
Identities = 116/375 (30%), Positives = 172/375 (45%), Gaps = 29/375 (7%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLD 1370
N+C R G CS LC G C+C + + S L + IR +
Sbjct: 3826 NEC-LRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSL-FP 3883
Query: 1371 TSDHTDVHVPVP--ELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGR--- 1425
H+ E + ++D G+VY+T+ I L + T R
Sbjct: 3884 GHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRR 3943
Query: 1426 ------------GLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEP 1473
GLK G+A+DWVA N+YWTD+GR+ IE +++ G RK LI+ +DEP
Sbjct: 3944 QIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEP 4003
Query: 1474 RAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVD 1533
AI V P +G ++W+DWG+ KIE A +DG+ R+ L+ ++ WP GL +DY R+YW D
Sbjct: 4004 HAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWAD 4063
Query: 1534 AHLDRIESADLNGKLRQVLVSH---VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
A L I S LNG V +SHPF++ + +IY + + ++ K+
Sbjct: 4064 AKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 4123
Query: 1591 ETVLANVEGLMDIIVVSPQRQTG-TNACGVNNGGCTHLCFARASDFVCACPD--EPDSRP 1647
+ + D+++ +Q TN C + C LC S VC CP+ D+
Sbjct: 4124 VNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRLDNGT 4181
Query: 1648 CSLVPGLVPP--APR 1660
C VP PP APR
Sbjct: 4182 CVPVPSPTPPPDAPR 4196
Score = 157 bits (396), Expect = 1e-37
Identities = 112/365 (30%), Positives = 165/365 (45%), Gaps = 33/365 (9%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF--LIFARRIDIRMVSLDIPY 1068
G CS LC + G C+C N + TC + + L A +IR + P+
Sbjct: 3832 GTCSQLC--NNTKGGHLCSCAR--NFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH 3887
Query: 1069 FADVVVPINITMKNTIAIGVDPQEGKVYWSD-----------------STLHRISRANLD 1111
A A+ V + G+VYW++ +T +R R
Sbjct: 3888 SAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDR 3947
Query: 1112 GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRA 1171
G H +I +GL+ G+A+D + VYWTD+G + IEV + G RK L+ +D P A
Sbjct: 3948 GVTHLNI--SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHA 4005
Query: 1172 IVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAH 1231
IV+ G MYW+DWG + K+E + MDG+ R L+ +N+ WP GL VD + +L WADA
Sbjct: 4006 IVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAK 4065
Query: 1232 TERIEAADLNGANRHTLVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVIL 1288
I + LNG + + HP+ + + + YIY + + + K S ++
Sbjct: 4066 LSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVN 4125
Query: 1289 VRSNLPGLMDMQAV-DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKT 1347
+ L D+ QP N C + C LCL PSG C CP G +L D T
Sbjct: 4126 LTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPNGKRL--DNGT 4181
Query: 1348 CDPSP 1352
C P P
Sbjct: 4182 CVPVP 4186
Score = 129 bits (323), Expect = 4e-29
Identities = 97/357 (27%), Positives = 162/357 (45%), Gaps = 30/357 (8%)
Query: 1310 FNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETY-----LLFSSRGSI 1364
F++C S G CS LC F C C G L+ D ++C E LL ++ +I
Sbjct: 151 FDEC-SVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNI 209
Query: 1365 RRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVF-------LDVIRRADLNGS 1417
L + + + ++D+ + V + V L R L G
Sbjct: 210 LATYLSGAQVSTI--TPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGF 267
Query: 1418 NMETVIGRGLKT--TDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRA 1475
E I L + +A+DW+ N Y+ D + I +G L++ L P+
Sbjct: 268 VDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKG 327
Query: 1476 IAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAH 1535
IA+ P G +F+TD+G I K+ER ++DG R L+++ + +P+G+TLD +R +YW DA+
Sbjct: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
Query: 1536 LDRIESADLNGKLRQVLVSH--VSHPFALTQQDRWIYWTD------WQTKSIQRVDKYSG 1587
LD IE D GK RQ ++ + H + LT + ++Y T+ Q S+ RV++++
Sbjct: 388 LDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNS 447
Query: 1588 RNKETVL-ANVEGLMDIIVVSPQRQTGTNACGVNN----GGCTHLCFARASDFVCAC 1639
+ V + G + I Q + ++AC + GGC+ +C S C
Sbjct: 448 TEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTC 504
Score = 117 bits (294), Expect = 8e-26
Identities = 91/296 (30%), Positives = 124/296 (41%), Gaps = 41/296 (13%)
Query: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDG---SDEENCPSAVPAPPCNLE 194
N C++ C C D C+ H + C+ G D+ C AV + +
Sbjct: 2472 NDTNSCELSPCRINNGGCQD-LCLLTH-QGHVNCSCRGGRILQDDLTC-RAVNSSCRAQD 2528
Query: 195 EFQCAYGRCILDIYHCDGDDDCGDWSDE--SDCSSHQPCRSGEFMCDSGLCINAGWRCDG 252
EF+CA G CI CDG C D SDE S C+S + C+ C +G C++ C+G
Sbjct: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR-CKKTFRQCSNGRCVSNMLWCNG 2587
Query: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTG---- 308
DC D SDE C + C +FRC G C+ S RC+ DC D SDE NC T
Sbjct: 2588 ADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSY 2647
Query: 309 ---SPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGC 365
+ L Q C +C+G NDCGD SDE ++C P C +N C
Sbjct: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE---RDC-PGVKRPRCPLNYFAC 2703
Query: 366 AQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC---AEEGYCSQGCTNSEGAFQC 418
R TC ++C +E +C++ C SE F+C
Sbjct: 2704 PSG----------------RCIPMSWTCDKEDDCEHGEDETHCNKFC--SEAQFEC 2741
Score = 78.2 bits (191), Expect = 7e-14
Identities = 110/461 (23%), Positives = 172/461 (37%), Gaps = 68/461 (14%)
Query: 146 RKCSDKEFRCSDG-SCIAEHWYCDGDTDCKDGSDE--ENCPSAVPAPPCNLEEFQC-AYG 201
+ CS K+F C D +CI++ W CDG+ DC DGSDE E CP + A C E C
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQS-KAQRCQPNEHNCLGTE 83
Query: 202 RCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCIN------AGWRCDGDAD 255
C+ C+G DC D SDE CR + C C + G C ++
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDEG-----PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSS 138
Query: 256 CDDQSDERNCTT-SMCTAEQFRCHSGRCVRLSWRCDGEDDCAD------NSDEENCENTG 308
Q+D + C C+ G C +L DG C D +C+
Sbjct: 139 FQLQADGKTCKDFDECSV------YGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKN 192
Query: 309 SPQCALDQFLCWNGRCIGQRKLCNG-VNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367
P L N + I L V+ S E C V+ G A
Sbjct: 193 EPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAA 252
Query: 368 KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELR 427
+ Q+ +C G + D HT +N + Q + W +
Sbjct: 253 QTQL-----KCARMPGLKGFVDEHT---INISLSLHHVEQMAID-------WLTGNF--- 294
Query: 428 PDRRSCKALGPEPVLLFANRIDIRQVLPHRSE---YTLLLNNLENAIALDFHHRRELVFW 484
F + ID R + +R+ TLL L N + VF+
Sbjct: 295 ---------------YFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFF 339
Query: 485 SDV-TLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGA 543
+D + ++ R +++G N ++V + + P G+ +D V +YW D+ IEV + +G
Sbjct: 340 TDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGK 399
Query: 544 HRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584
R+ ++ Q + L E +Y T+ N + +S+
Sbjct: 400 GRQTII-QGILIEHLYGLTVFENYLYATNSDNANAQQKTSV 439
Score = 65.9 bits (159), Expect = 4e-10
Identities = 54/173 (31%), Positives = 72/173 (41%), Gaps = 19/173 (10%)
Query: 9 LLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL 68
LL AL+ A A C F C + TCI W+CDG+ DC D SDE I
Sbjct: 12 LLSALVAA---AIDAPKTCSPKQFACR----DQITCISKGWRCDGERDCPDGSDEAPEIC 64
Query: 69 P-----TCSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDE-QDCPPRECEEDEFPCQNGY 121
P C P + +C C+ S +C+G DC D SDE C + CQ+ +
Sbjct: 65 PQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQH-H 123
Query: 122 CIRSLWHCDGDN-DCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDC 173
C+ +L DG C + Q D + C D + G+C DG C
Sbjct: 124 CVPTL---DGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
Score = 36.2 bits (82), Expect = 0.31
Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 52/179 (29%)
Query: 41 ECTCIPAQW--QCDGDNDCGDHSDEDGCI------LPTCSPLDFHCDNG----KCIRR-- 86
+C C P +C+ D C +H G +PTC C G KC ++
Sbjct: 4219 KCRCQPRYTGDKCELDQ-CWEHCRNGGTCAASPSGMPTC-----RCPTGFTGPKCTQQVC 4272
Query: 87 SWVCDGDNDCEDDSDEQD------------CPPRECEEDEFPCQNGYCIRSLWHC----D 130
+ C ++ C + Q C R+C +GYC + C D
Sbjct: 4273 AGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC--------SGYC-ENFGTCQMAAD 4323
Query: 131 GDNDCGDNS---DEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAV 186
G C + +C++ KCS RC +G+C+ D +C DG +C + V
Sbjct: 4324 GSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCV 4378
Score = 35.0 bits (79), Expect = 0.70
Identities = 31/105 (29%), Positives = 41/105 (39%), Gaps = 21/105 (20%)
Query: 331 CNGVNDCGDNSDESPQQNCRPRTGEENCNV--------NNGGCAQKCQMVRGAVQCTCHT 382
C C N+ P+ C+PR + C + N G CA G C C T
Sbjct: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAAS---PSGMPTCRCPT 4260
Query: 383 GYRLTEDGHTCQDVNECAEEGYCSQG--CTNSEG-AFQCWCETGY 424
G+ G C CA GYC+ CT ++G QC C G+
Sbjct: 4261 GF----TGPKCTQ-QVCA--GYCANNSTCTVNQGNQPQCRCLPGF 4298
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 1099 bits (2843), Expect = 0.0
Identities = 553/1226 (45%), Positives = 778/1226 (63%), Gaps = 26/1226 (2%)
Query: 433 CKALGPEPVLLFANRIDIRQV--LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLD 490
C L P+LL+ANR D+R V + T+++ LE+A A+DF L++WSDV+ +
Sbjct: 14 CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
Query: 491 RILRANLNGS-NVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLL 549
I R N + +V+ VV +GL SP GLA DW+ +KLYWTDS T+RIEV+NLDG+ RKVL
Sbjct: 74 AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF 133
Query: 550 WQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAG 609
WQ L++PRAIAL P G +YWTDWG P+IE + MDGS R II ++ ++WPNGLT+DY
Sbjct: 134 WQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEE 193
Query: 610 RRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 669
+++YW DAK + I ++NLDG++R+AV+ LPHPFA+T+FED LYWTDW T SI + NK+
Sbjct: 194 QKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
Query: 670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTG 727
TG+ I + + PMDIH QRQP N CG +NGGC+HLCL P Y CACPTG
Sbjct: 254 TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTG 313
Query: 728 FRKI-SSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDH 786
+ + + C + LL ARR D+RRIS DT D +D V+ L D+R A+A+D+D + +
Sbjct: 314 VKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGY 373
Query: 787 VYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTD 846
+YWTD I R+ DG+G + VV + P G+A+DWV LYWTD GTDRIEV +
Sbjct: 374 IYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLN 433
Query: 847 GSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPN 906
G+MR +LI E+L+ PR IV++PM GYMYWTDWG PKIERA +D S R V+++++L WPN
Sbjct: 434 GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPN 493
Query: 907 GLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTK 966
GLA+DY ++YW DA IE DG+ R+VL+ ++PH FG TL G+ +YWTDWQ +
Sbjct: 494 GLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRR 553
Query: 967 SIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
SI+ + + +RE + + L +LM + + R S PCA ENGGCSHLCL P G
Sbjct: 554 SIERVHKRSA-EREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLY--RPQGL 610
Query: 1027 SCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAI 1086
C CP G L+SD KTC +FL+F+RR DIR +SL+ +V +P+ +K A+
Sbjct: 611 RCACPIGFELISDMKTCIV-PEAFLLFSRRADIRRISLETNN-NNVAIPLT-GVKEASAL 667
Query: 1087 GVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTN 1146
D + ++YW+D +L ISRA ++GS E ++ GL +G+AVD +G+ +YW DTGTN
Sbjct: 668 DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTN 727
Query: 1147 RIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLI 1206
RIEV LDG R+VLVW++LDSPRA+ L GFMYWT+WG K++R+ MDGS+R L+
Sbjct: 728 RIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV 787
Query: 1207 NNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIY 1266
N+G NGLT+D A +L W D T IE++++ G NR + + HP+GLT YIY
Sbjct: 788 -PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIY 846
Query: 1267 WTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLP 1326
WTDW RSI RA+K +G N +++ +L +MD+ ++ G+N+C S NG CSHLCL
Sbjct: 847 WTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLA 906
Query: 1327 RP-SGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELN 1385
P GF C CP L D +TC +P T+LLFS + +I R+ +D D+ +P+ L
Sbjct: 907 VPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
Query: 1386 NVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD------GLAVDWVA 1439
NV ++DYD +D ++Y+ D ++IR+A +GS TV+ + + + L++D +
Sbjct: 966 NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS 1025
Query: 1440 RNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA-KIER 1498
R +YWT N I +RLDG V++ D PRA+ V P KGY+++T+ + KIER
Sbjct: 1026 RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIER 1085
Query: 1499 ANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVS 1557
A LDG+ER+VL + L P L LD +++W D+ L RIES+DL+G R VL S++
Sbjct: 1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNIL 1145
Query: 1558 HPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSP--QRQTGTN 1615
P LT + W+YW D Q + I+++D + V A + L DI V ++ +
Sbjct: 1146 QPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQH 1205
Query: 1616 ACGVNNGGCTHLCFARASDFV-CACP 1640
C +NGGC+H+C + C+CP
Sbjct: 1206 PCAQDNGGCSHICLVKGDGTTRCSCP 1231
Score = 743 bits (1919), Expect = 0.0
Identities = 401/1011 (39%), Positives = 584/1011 (57%), Gaps = 65/1011 (6%)
Query: 358 CNVNNGGCAQKCQM--VRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGA 415
C ++NGGC+ C M V+ QC C TG +L E+G TC+D
Sbjct: 286 CGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-------------------- 325
Query: 416 FQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQV---LPHRSEYTLLLNNLENAIA 472
G +LL A R D+R++ P ++ L L ++ +AIA
Sbjct: 326 ---------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIA 364
Query: 473 LDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532
+D+ ++W+D + I R+ ++GS + VV+ + P G+AVDWV LYWTD+GT
Sbjct: 365 IDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGT 424
Query: 533 SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592
RIEV L+G RK+L+ ++LE+PRAI L PM G +YWTDWG P+IE +++DGS R ++
Sbjct: 425 DRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVL 484
Query: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDS 652
+T L WPNGL +DY ++YW DAK IE N DG+ R+ ++ +PH F T+ D
Sbjct: 485 VNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY 544
Query: 653 LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHL 712
+YWTDW +SI +K + + +E+I ++L M + + R G N C + NGGC+HL
Sbjct: 545 VYWTDWQRRSIERVHKRSAE-REVIIDQLPDLMGLKATNVHR-VIGSNPCAEENGGCSHL 602
Query: 713 CLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADV 772
CL Q CACP GF IS + FLLF+RR DIRRIS +T + ++ IPL V
Sbjct: 603 CLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN-NNVAIPLTGV 661
Query: 773 RSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYW 832
+ A ALD+D D+ +YWTD+S TISRA +G+ E VV+ L+ P G+A+DW+ LYW
Sbjct: 662 KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721
Query: 833 TDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDAS 892
D GT+RIEV+ DG R VL+W++LD PR + ++P G+MYWT+WG PKI+RA MD S
Sbjct: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
Query: 893 GRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLT 952
R ++ N+ NGL IDY +RLYW D IE + + G R+V I LPHPFGLT
Sbjct: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREV-IADDLPHPFGLT 839
Query: 953 LYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGG 1012
Y + IYWTDW +SI+ A++ +G +R +Q +L+ +MDI VFH R CA NG
Sbjct: 840 QYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGH 899
Query: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADV 1072
CSHLCL P GF C CP +L +D +TCS +FL+F+++ I + +D D+
Sbjct: 900 CSHLCLAVP-VGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDI 957
Query: 1073 VVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD----- 1127
++PI+ +++N AI DP + ++YW DS + I +A DGSQ ++ + + + +
Sbjct: 958 ILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQP 1016
Query: 1128 -GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186
L++D R +YWT TN I V LDG V++ D PRA+V+ E G+MY+T+
Sbjct: 1017 YDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNL 1076
Query: 1187 GENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245
E + K+ER+ +DG++R VL + L P L +D +L WAD+ RIE++DL+GANR
Sbjct: 1077 QERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Query: 1246 HTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVD- 1303
L S + P GLT+ ++++YW D Q + I + D V++ + L D+ AV
Sbjct: 1137 IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKE 1196
Query: 1304 -RAQPLGFNKCGSRNGGCSHLCLPRPSGFS-CACPTGIQLKGDGKTCDPSP 1352
Q + C NGGCSH+CL + G + C+CP + L D +C P
Sbjct: 1197 LNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP 1247
Score = 485 bits (1248), Expect = e-136
Identities = 272/682 (39%), Positives = 395/682 (57%), Gaps = 29/682 (4%)
Query: 397 NECAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL- 454
N CAEE G CS C +C C G+EL D ++C + PE LLF+ R DIR++
Sbjct: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISL 647
Query: 455 -PHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESP 513
+ + + L ++ A ALDF ++W+D++L I RA +NGS +E VV GL+ P
Sbjct: 648 ETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
Query: 514 GGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW 573
G+AVDW+ LYW D+GT+RIEV+ LDG HR+VL+W++L+ PRA+AL P EG +YWT+W
Sbjct: 708 EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 767
Query: 574 GNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRK 633
G P+I+ ++MDGS R + ++ NGLTIDYA RR+YW D ++IE +N+ G +R+
Sbjct: 768 GGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE 826
Query: 634 AVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQ 693
VI+ LPHPF +T ++D +YWTDW +SI ANK +G+N+ II+ L + MDI H
Sbjct: 827 -VIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSS 885
Query: 694 RQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMD 751
RQ +G N C +NG C+HLCL P G + C CP + + + + FLLF+++
Sbjct: 886 RQ-SGWNECASSNGHCSHLCLAVPVG-GFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSA 943
Query: 752 IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVV 811
I R+ D + D ++P+ +R+ A+D+D D +YW D + I +A+ DG+ VV
Sbjct: 944 INRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVV 1003
Query: 812 DTSLES------PAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIV 865
+S+ S P L+ID + +YWT T+ I V DG V++ DRPR +V
Sbjct: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVV 1063
Query: 866 VEPMGGYMYWTD-WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGM 924
V P GYMY+T+ SPKIERA +D + R+V+ S L+ P LA+D +L+WAD+ +
Sbjct: 1064 VNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL 1123
Query: 925 KTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQE 984
+ IE + L G+ R VL S + P GLT++ +YW D Q + I+ D R +Q
Sbjct: 1124 RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQA 1183
Query: 985 NLENLMDIHVFH--RRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSD--- 1039
+ L DIH + PCA +NGGCSH+CL + + C+CP + LL D
Sbjct: 1184 RIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGT-TRCSCPMHLVLLQDELS 1242
Query: 1040 ---GKTCSPGMNSFLIFARRID 1058
TCSP F F ID
Sbjct: 1243 CGEPPTCSP--QQFTCFTGEID 1262
Score = 121 bits (304), Expect = 6e-27
Identities = 57/125 (45%), Positives = 75/125 (60%), Gaps = 8/125 (6%)
Query: 221 DESDCSSHQPCRSGEFMCDSGL--CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCH 278
DE C C +F C +G CI WRCDG +C+D SDE NC +C+ QF+C
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
Query: 279 SGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCG 338
SG+C+ + RC+G+ +C D SDE+NCE C +DQF C NG+CIG+ K C+ DC
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL----CLIDQFRCANGQCIGKHKKCDHNVDCS 1352
Query: 339 DNSDE 343
D SDE
Sbjct: 1353 DKSDE 1357
Score = 121 bits (303), Expect = 7e-27
Identities = 68/167 (40%), Positives = 87/167 (52%), Gaps = 16/167 (9%)
Query: 28 GRSHFTCAVSALG--ECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK--C 83
G SH C V G C+C + CG+ PTCSP F C G+ C
Sbjct: 1213 GCSHI-CLVKGDGTTRCSCPMHLVLLQDELSCGEP--------PTCSPQQFTCFTGEIDC 1263
Query: 84 IRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQC 143
I +W CDG +CED SDE +CP C E +F C +G CI C+GD +C D SDE+
Sbjct: 1264 IPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCIDGALRCNGDANCQDKSDEKN 1321
Query: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC-PSAVPAP 189
C +FRC++G CI +H CD + DC D SDE +C P+ PAP
Sbjct: 1322 CEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAP 1368
Score = 114 bits (285), Expect = 9e-25
Identities = 58/148 (39%), Positives = 80/148 (54%), Gaps = 16/148 (10%)
Query: 175 DGSDEENCP----------SAVPAPPCNLEEFQCAYGR--CILDIYHCDGDDDCGDWSDE 222
DG+ +CP S P C+ ++F C G CI + CDG +C D SDE
Sbjct: 1223 DGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
Query: 223 SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282
+C C +F C SG CI+ RC+GDA+C D+SDE+NC +C +QFRC +G+C
Sbjct: 1283 LNCPV---CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQC 1338
Query: 283 VRLSWRCDGEDDCADNSDEENCENTGSP 310
+ +CD DC+D SDE +C T P
Sbjct: 1339 IGKHKKCDHNVDCSDKSDELDCYPTEEP 1366
Score = 105 bits (263), Expect = 3e-22
Identities = 52/120 (43%), Positives = 68/120 (56%), Gaps = 10/120 (8%)
Query: 148 CSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCIL 205
CS ++F C G CI W CDG T+C+D SDE NCP C+ +FQCA G+CI
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV------CSESQFQCASGQCID 1302
Query: 206 DIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
C+GD +C D SDE +C C +F C +G CI +CD + DC D+SDE +C
Sbjct: 1303 GALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 76.3 bits (186), Expect = 3e-13
Identities = 53/168 (31%), Positives = 73/168 (43%), Gaps = 39/168 (23%)
Query: 230 PCRSGEFMCDSGLCINAGWRCDGDADCDDQ------SDERNC-TTSMCTAEQFRCHSGR- 281
PC C S +C+ G DG C DE +C C+ +QF C +G
Sbjct: 1206 PCAQDNGGC-SHICLVKG---DGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEI 1261
Query: 282 -CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDN 340
C+ ++WRCDG +C D+SDE NC P C+ QF C +G+CI CNG
Sbjct: 1262 DCIPVAWRCDGFTECEDHSDELNC-----PVCSESQFQCASGQCIDGALRCNG------- 1309
Query: 341 SDESPQQNCRPRTGEENCNV---------NNGGCAQKCQMVRGAVQCT 379
NC+ ++ E+NC V NG C K + V C+
Sbjct: 1310 -----DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 1080 bits (2793), Expect = 0.0
Identities = 609/1668 (36%), Positives = 923/1668 (55%), Gaps = 105/1668 (6%)
Query: 44 CIPAQWQCDGDNDCGDHSDEDG--CILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSD 101
CI A+W+CDGD+DC D SDED C +C F C N +CI + W+CDG NDC + D
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNED 916
Query: 102 E--QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ--CDMRKCSD-KEFRCS 156
E Q C R C+ D+F C NG CI W CD ++DCGD +DE C+ C +F C
Sbjct: 917 ESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCK 976
Query: 157 DGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDC 216
G CI+ W+CD D DC DGSDE C + C +F+C+ GRCI + CDGD+DC
Sbjct: 977 SGRCISSKWHCDSDDDCGDGSDEVGCVHS-----CFDNQFRCSSGRCIPGHWACDGDNDC 1031
Query: 217 GDWSDES--DCSS---HQP--CRSGEFMCD-SGLCINAGWRCDGDADCDDQSDERNC--T 266
GD+SDE+ +C+ H P C EF C G C+ WRCDG+ DC+D SDE+ C T
Sbjct: 1032 GDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGT 1091
Query: 267 TSMCTAE-QFRCHS-GRCVRLSWRCDGEDDCADNSDEENCEN--TGSPQ--CALDQFLCW 320
+C + +F C S GRC+ +W CDG+ DC D SDE++C++ G P+ CA D +C
Sbjct: 1092 IRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVC- 1150
Query: 321 NGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRG-AVQCT 379
+ KLCNG DC D SDE C + C++NNGGC+ C +V G + C+
Sbjct: 1151 ----LQPEKLCNGKKDCPDGSDEG--YLC------DECSLNNGGCSNHCSVVPGRGIVCS 1198
Query: 380 CHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGP- 438
C G +L +D TC+ V+ C+ CSQ C + +C C G++L D SC ++ P
Sbjct: 1199 CPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPF 1258
Query: 439 EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLN 498
E ++F+ R +IR++ H+ +Y+LL+ L N IALDFH + L++W+DV DRI R L+
Sbjct: 1259 EAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLS 1318
Query: 499 GSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLE 554
S +E VV GL +P GL VDW+ +YW DS +IEVA LDG+ R L+ +E
Sbjct: 1319 ESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAME 1378
Query: 555 KPRAIALHPMEGTIYWTDW-GNTPRIEASSMDGSGRRIIADTHL--FWPNGLTIDYAGRR 611
PRAIAL P G ++WTDW N PRIE++SM G+GR+ I WPNGLT+D+ +R
Sbjct: 1379 HPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKR 1438
Query: 612 MYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 669
+ W DA+ I A DG++ +I + L HPFA++++ +YWTDW T +++ ANK+
Sbjct: 1439 IVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKW 1498
Query: 670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC--GDNNGGCTHLCLPS-GQNYTCACPT 726
TG+N +I+ P D+ HP RQP N C D G C+H+CL + ++ CACP
Sbjct: 1499 TGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPH 1558
Query: 727 GFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLS-DDVIPLADVRSAVALDWDSRDD 785
+ S + KFLL+ARR +IR + D + + D+ +D+D+ ++
Sbjct: 1559 LMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEE 1618
Query: 786 HVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTD--RIEVA 843
+YWTD+ T TI RA +GTG E V+ ++S GLA+DWV+ LYW + D +I VA
Sbjct: 1619 RLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVA 1678
Query: 844 NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903
DGS++T +I +D+P+ + P+ G +YWTD I A MD S +++ N
Sbjct: 1679 RLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTDGNT---INMANMDGSNSKILF-QNQK 1733
Query: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVL--IGSQLPHPFGLTLYGERIYWT 961
P GL+IDY +LYW +G TI LDG +V+ + +L LT+ ++++W
Sbjct: 1734 EPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWA 1793
Query: 962 DWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSP 1021
D + + + G + L+ ++ + V+ + S C + NGGCS LCL +
Sbjct: 1794 DQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTS 1853
Query: 1022 NPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMK 1081
+ +C C G L + +C G+ SFL+++ IR + L+ D ++PI+ T
Sbjct: 1854 ETTR-TCMCTVGYYLQKNRMSCQ-GIESFLMYSVHEGIRGIPLEPSDKMDALMPISGT-- 1909
Query: 1082 NTIAIGVD--PQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVY 1139
+ A+G+D + +YW+D ++ISRA D + EDIIT GL +G+AVD I +Y
Sbjct: 1910 -SFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIY 1968
Query: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
WTD G N IEV L+GS R V++ Q LD PR+I ++ E G ++WT+WG+ + ++ +DG
Sbjct: 1969 WTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDG 2028
Query: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADL-NGANRHTLVSPVQ-HPYG 1257
S++ VL++ + WPNG+++D ++L W DA T++IE DL G NR ++S +
Sbjct: 2029 SEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFS 2088
Query: 1258 LTLLDSYIYWTD--WQTRSIHRADKGTGSNVILVRSNL-PGLMDMQAVDRAQPLGFNKCG 1314
+ + +YIYW+D S+ R K + I +R+ L L +++ +R + G N C
Sbjct: 2089 VAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCA 2148
Query: 1315 SRNGGCSHLCLPR-PSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSD 1373
NGGC LCL R S +CAC G L DG TC E YLL+S R ++ I L SD
Sbjct: 2149 RDNGGCKQLCLYRGNSRRTCACAHG-YLAEDGVTC-LRHEGYLLYSGRTILKSIHL--SD 2204
Query: 1374 HTDVHVPVPE------LNNVISLDYD-----SVDGKVYYTDVFLDVIRRADLNGSNMETV 1422
T+++ P+ NVI+L +D +++Y+D I+ N + + +
Sbjct: 2205 ETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVI 2264
Query: 1423 IGRGLKTTDGLAVDWVARNLYWTDT-----GRNTIEASRLDGSCRKVLINNSLDE-PRAI 1476
+ + + +GLA LYWT + R+T++ +R R+ +I S D+ P +
Sbjct: 2265 V-ENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVL 2323
Query: 1477 AVFPRKGYLFWTDWG-HIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAH 1535
A+ + +FWT+W I R+ L G +V+++TD+ PNGLT+DY ++Y+ D
Sbjct: 2324 ALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGS 2383
Query: 1536 LDRIESADLNGKLRQVLVSHVSHPF-ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVL 1594
L +IE + +G R V+V F +L D +I+W+DW ++I R +KY+G + + +
Sbjct: 2384 LGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILR 2443
Query: 1595 ANV--EGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFV-CAC 1639
+++ + + I V + + C + NGGC LC + V C+C
Sbjct: 2444 SDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 2491
Score = 547 bits (1410), Expect = e-155
Identities = 296/738 (40%), Positives = 405/738 (54%), Gaps = 60/738 (8%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPL---------DFH 77
C F CA + TCIP +C+ + DC D SDE C C+
Sbjct: 2591 CATVEFRCA-----DGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIR 2645
Query: 78 CDN-GKCIRRSWVCDGDNDCEDDSDEQDCP---PRECEEDEFPCQNGYCIRSLWHCDGDN 133
C++ C+ +W+CDG NDC D SDE CP +CEE+ F C +G CI + W CDG
Sbjct: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQK 2705
Query: 134 DCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCN 192
DC D DE CD CS +F CS CI++HW CDG+ DC DG DE + S A C
Sbjct: 2706 DCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD--SICGAITCA 2762
Query: 193 LEEFQCAYGR-CILDIYHCDGDDDCGDWSDE---SDCSSHQPCRSGEFMCDSGLCINAGW 248
+ F C R C+ + CDG+ DC D SDE + C+ + C FMC + +CI +
Sbjct: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
Query: 249 RCDGDADCDDQSDER-NCTTSMCTAEQFRCHSGRC-VRLSWRCDGEDDCADNSDEENCE- 305
CD D DC D SDE C C E+F C GRC + W+CDG+ DC D+SDE
Sbjct: 2823 VCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNP 2882
Query: 306 --NTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN- 362
+ C F+C NGRCI LC+ +DCGD SD E NC++N
Sbjct: 2883 KCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSD------------ERNCHINEC 2930
Query: 363 -----GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQ 417
GC+Q CQ + + +C C G++L +DG TC D++EC+ CSQ C N+ G ++
Sbjct: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
Query: 418 CWCETGYELRPDR-RSCKALG-PEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDF 475
C C GYE++PD CK+L EP L+ A+ +IR++ S YTLL L N IA+DF
Sbjct: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
Query: 476 HHRRELVFWSDVTL---DRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532
+R E ++W D + RI R LNGS+++ V +T + P LAVDW+ LYW+D+
Sbjct: 3051 DYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEK 3108
Query: 533 SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592
IEV+ L+G + +L+ + L+ PR ++L P G +YW D P I MDG+ + ++
Sbjct: 3109 RIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVV 3168
Query: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDS 652
+T + P LTIDY RR+YW D H IE +N+DGSHR V +Q +P A+T+FED
Sbjct: 3169 IETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHRHKVPNQDIPGVIALTLFEDY 3226
Query: 653 LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQP-AGKNRCGDNNGGCTH 711
+YWTD TKS++ A+K +G ++ + H DI H RQP K+ C NNGGC+H
Sbjct: 3227 IYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSH 3286
Query: 712 LC-LPSGQNYTCACPTGF 728
LC L G+ +TCACPT F
Sbjct: 3287 LCLLAPGKTHTCACPTNF 3304
Score = 447 bits (1151), Expect = e-125
Identities = 267/784 (34%), Positives = 367/784 (46%), Gaps = 95/784 (12%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK 82
PE +C +F C + CI W CD D DC D SDE C TC P +F C N
Sbjct: 3432 PENSCSPDYFQCKTTK----HCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN 3487
Query: 83 CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
CI W CD NDC D+SDE++C P+ C +F C NG C+ S + CDGD DC D SDE+
Sbjct: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDER 3547
Query: 143 CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGR 202
CS +FRCS+G CI W CDG DCK G DE++C A +P C+ E+ CA
Sbjct: 3548 NCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPA--SPTCSSREYICASDG 3605
Query: 203 CILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC-DSGLCINAGWRCDGDADCDDQSD 261
CI C+G+ DC D SDE DC + C+ +F C + CI W CDG DC D SD
Sbjct: 3606 CISASLKCNGEYDCADGSDEMDCVTE--CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSD 3663
Query: 262 ERNCTT--SMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDE---------------ENC 304
E NC ++C A++F C++ C W CDGEDDC DNSDE C
Sbjct: 3664 EENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRC 3723
Query: 305 ENTG-------------------------------SPQCALDQFLCWNGRCIGQRKLCNG 333
N + C D+F C N +CI C+
Sbjct: 3724 RNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDR 3783
Query: 334 VNDCGDNSDESPQQNCRPRTGEENC--NVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGH 391
++DCGD SDE Q CR E C NVN G C ++ +V C C G++
Sbjct: 3784 LDDCGDGSDE---QGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR 3840
Query: 392 TCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEP-VLLFANRIDI 450
C+D+NEC G CS C N EG+++C C+ ++ R +C A G E VL AN DI
Sbjct: 3841 QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDI 3898
Query: 451 RQVL---PHRSEYTLLLNNLENA--IALDFHHRRELVFWS-DVTLDRILRANLNGSNVEE 504
+ + ++ + + N+ +D +++R+++ WS I ++G +
Sbjct: 3899 LGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQ 3958
Query: 505 ----VVSTGLESPGGLAVDWVHDKLYWTDSGTSR---------------IEVANLDGAHR 545
++ + P +AVDWV +YWTD I V L+G +
Sbjct: 3959 ANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNC 4018
Query: 546 KVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTI 605
LL +P AIA++P G +YWT G+ IE ++MDG+ RRI+ +L P GL +
Sbjct: 4019 TRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAV 4078
Query: 606 DYAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPHPFAITVFEDSLYWTDWHTKSI 663
DY R+YW D + +I DGS+ +S QGL HP I +FED +Y +
Sbjct: 4079 DYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGV 4137
Query: 664 NSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCA 723
KF + E + + + H +Q N C D C LCL + TC
Sbjct: 4138 FRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCV 4195
Query: 724 CPTG 727
CP G
Sbjct: 4196 CPEG 4199
Score = 443 bits (1140), Expect = e-124
Identities = 273/814 (33%), Positives = 416/814 (51%), Gaps = 48/814 (5%)
Query: 269 MCTAEQFRCHSG-RCVRLSWRCDGEDDCADNSDE--ENCENTGSPQCALDQFLCWN-GRC 324
+C +F CH CV SW CDG+ DC D+SDE + C +C L+ C +C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 325 IGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGY 384
+ +LCNGV DC D DE +C+ NC N C KC MVR + +C C G+
Sbjct: 91 VHLSQLCNGVLDCPDGYDEGV--HCQELLS--NCQQLN--CQYKCTMVRNSTRCYCEDGF 144
Query: 385 RLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKA----LGPEP 440
+TEDG +C+D +ECA G CSQ C N+ G++ C C GY ++PD RSCKA P
Sbjct: 145 EITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
Query: 441 VLLFANRIDIRQVLPHRSEYTLLLNNLENAI-ALDFHHRRELVFW-----SDVTLDRILR 494
+LL AN I + S+ L + N I LDF + +++ W S L I
Sbjct: 205 ILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQI 264
Query: 495 ANLNGSNVEEVVS--TGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQN 552
G E ++ + +A+DW+ LY+ D RI V N +G+ L+
Sbjct: 265 TKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE 324
Query: 553 LEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRM 612
L P+AIA+ P+ G +++TD+GN ++E MDG R I D+ P L +D + +
Sbjct: 325 LHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLV 384
Query: 613 YWVDAKHHVIERANLDGSHRKAVI-SQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG 671
YWVD + + G +R VI + + H + ITVFED LY T+ +I N+F G
Sbjct: 385 YWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNG 444
Query: 672 KNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNN-----GGCTHLCLPSG--QNYTCAC 724
+ + K+ I + QP ++ + + GGC+H+CL S + TC C
Sbjct: 445 TDIHSL-IKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
Query: 725 PTGFRKIS-SHACAQSLDKFLLF---ARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW 780
TGF S +C + ++ LF R +R + +T+ + +IP+ ++ + ALD+
Sbjct: 504 RTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDF 563
Query: 781 DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDR- 839
+ +++Y+ D ++ I R K DGT +E ++ L++ G+A+DW+ N LYWT+ G +
Sbjct: 564 HAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKT 623
Query: 840 IEVANTD--GSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW------GASPKIERAGMDA 891
I VA + R L+ + PR IVV+P+ G+MYWTDW + +IE+A MD
Sbjct: 624 INVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDG 683
Query: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI-GSQLPHPFG 950
RQ+ ++S + WPNGL +D+ + LYW DA IE L+G+ RK++ G +L HPFG
Sbjct: 684 FNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFG 743
Query: 951 LTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMEN 1010
L+ +G ++WTD+ SI D +T + L+ L + ++ R+ C + N
Sbjct: 744 LSHHGNYVFWTDYMNGSIFQLDLITS-EVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNN 802
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCS 1044
GGCS LCL P G C C L +G TC+
Sbjct: 803 GGCSTLCLAI--PGGRVCACADNQLLDENGTTCT 834
Score = 337 bits (863), Expect = 9e-92
Identities = 215/680 (31%), Positives = 338/680 (49%), Gaps = 39/680 (5%)
Query: 707 GGCTHLCLPSGQNYTCACPTGF-RKISSHACAQSLDK-----FLLFARRMDIRRISFDTE 760
G C+ C + +YTC+C G+ + + +C ++ LL A I +
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
Query: 761 DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDT-----ISRAKWDGTGQEVVVDT-- 813
++ + + LD+ +D + W + + I K G E ++
Sbjct: 223 KMA--TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQ 280
Query: 814 SLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYM 873
S + +AIDW+T LY+ D DRI V N++GS+ LI L P+ I V+P+ G +
Sbjct: 281 SFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKL 340
Query: 874 YWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLD 933
++TD+G K+ER MD R II S P LA+D ++ +YW D + +
Sbjct: 341 FFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQ 400
Query: 934 GSKRKVLI-GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDI 992
G R +I G Q+ H +G+T++ + +Y T+ +I +R G D +L + +EN I
Sbjct: 401 GKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGI 459
Query: 993 HVFHRRRPPVSTPCAME------NGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPG 1046
++ +R P A E GGCSH+CL S + +C C TG NL SDG++C
Sbjct: 460 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP 519
Query: 1047 MNSFLIF---ARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLH 1103
N +F R +R + L+ + ++PI + N A+ + +Y++D+T
Sbjct: 520 KNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIE-NLVNPRALDFHAETNYIYFADTTSF 578
Query: 1104 RISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNR-IEVGNLD--GSMRKV 1160
I R +DG++ E I+ L +G+AVD IG +YWT+ G + I V L+ RK
Sbjct: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
Query: 1161 LVWQNLDSPRAIVLYHEMGFMYWTDWGEN------AKLERSGMDGSDRAVLINNNLGWPN 1214
L+ + PR IV+ G+MYWTDW E+ ++E++ MDG +R + + + + WPN
Sbjct: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698
Query: 1215 GLTVDKASSQLLWADAHTERIEAADLNGANRHTLVS--PVQHPYGLTLLDSYIYWTDWQT 1272
GLT+D ++ L W DA+ + IE LNG +R + S + HP+GL+ +Y++WTD+
Sbjct: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758
Query: 1273 RSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFS 1332
SI + D T S V L+R P L +Q D + G N C NGGCS LCL P G
Sbjct: 759 GSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRV 817
Query: 1333 CACPTGIQLKGDGKTCDPSP 1352
CAC L +G TC +P
Sbjct: 818 CACADNQLLDENGTTCTFNP 837
Score = 336 bits (862), Expect = 1e-91
Identities = 216/716 (30%), Positives = 366/716 (51%), Gaps = 38/716 (5%)
Query: 389 DGHTCQDVNECA-EEGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFAN 446
D Q N C G CSQ C SE C C GY L+ +R SC+ G E L+++
Sbjct: 1828 DKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQ--GIESFLMYSV 1885
Query: 447 RIDIRQVLPHRSEYT---LLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVE 503
IR + S+ + ++ A+ +DFH + ++W+D+ ++I RA + + E
Sbjct: 1886 HEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKE 1945
Query: 504 EVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHP 563
++++ GL G+AVDW+ +YWTD G + IEVA L+G+ R V++ Q L++PR+IA+HP
Sbjct: 1946 DIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHP 2005
Query: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623
+G ++WT+WG P I + +DGS + ++ + WPNG++IDY ++YW DA+ IE
Sbjct: 2006 EKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIE 2065
Query: 624 RANLD-GSHRKAVISQGLPHPFAITVFEDSLYWTD--WHTKSINSANKFTGKNQEIIRNK 680
R +L+ G +R+ V+S F++ VF +YW+D S+ +K +R
Sbjct: 2066 RIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTG 2125
Query: 681 LHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN-YTCACPTGFRKISSHACAQS 739
L + + + + G N C +NGGC LCL G + TCAC G+ C +
Sbjct: 2126 LGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRH 2185
Query: 740 LDKFLLFARRMDIRRISF-DTEDLSDDVIPLADVR-----SAVALDWDSR---DDHVYWT 790
+ +LL++ R ++ I D +L+ + P + R A+A D++ R + ++++
Sbjct: 2186 -EGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYS 2244
Query: 791 DVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGS-- 848
D I K + ++V+V+ ++ S GLA + LYWT + T I D +
Sbjct: 2245 DAHFGNIQLIKDNWEDRQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRP 2303
Query: 849 ----MRTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLT 903
V+ D P + ++ M+WT+W P I R+ + QV++S+++
Sbjct: 2304 GAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDIL 2363
Query: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963
PNGL IDY +++LY++D + IE DGS+R V++ S L +Y I+W+DW
Sbjct: 2364 TPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDW 2423
Query: 964 QTKSIQSADRLTGLDRETLQENL--ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSP 1021
++I +++ TG D + L+ ++ + + I V + +PCA+ NGGC LCL +P
Sbjct: 2424 GRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTP 2483
Query: 1022 NPSGFSCTCPTGINLLSDGK--TCSPGMNSFLIF----ARRIDIRMVSLDIPYFAD 1071
N +C+C LL D + T + N++ F ID ++ IP+ D
Sbjct: 2484 N-GRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKD 2538
Score = 321 bits (823), Expect = 4e-87
Identities = 209/690 (30%), Positives = 339/690 (49%), Gaps = 53/690 (7%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNS-----FLIFARRIDIRMVSLD 1065
G CS C + ++C+C G + D ++C + L+ A I + L+
Sbjct: 163 GTCSQTCRNTHG--SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220
Query: 1066 IPYFADVVVPINITMKNTIAIGVDPQEGKVYW-----SDSTLHRISRANLDGSQHEDIIT 1120
A + ++ + E + W S + L I G E I
Sbjct: 221 GSKMATLS---SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTIN 277
Query: 1121 T--GLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM 1178
+A+D + R +Y+ D +RI V N +GS+ L+ L +P+AI +
Sbjct: 278 ILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIA 337
Query: 1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
G +++TD+G AK+ER MDG +R +I++ P L +D + + W D + + +
Sbjct: 338 GKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 397
Query: 1239 DLNGANRHTLVS--PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV--ILVRSNLP 1294
D G NRHT++ V+H YG+T+ + Y+Y T+ +I R ++ G+++ ++ N
Sbjct: 398 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW 457
Query: 1295 GLMDMQAVDRAQP-LGFNKCG----SRNGGCSHLCLPRPS--GFSCACPTGIQLKGDGKT 1347
G+ Q R QP + + C GGCSH+CL S +C C TG L DG++
Sbjct: 458 GIRIYQ--KRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRS 515
Query: 1348 CD-PSPETYLLFSS--RGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDV 1404
C P E +L + G +R + L+T + +P+ L N +LD+ + +Y+ D
Sbjct: 516 CKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADT 575
Query: 1405 FLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG-RNTIEASRLD--GSC 1461
+I R ++G+ ET++ L +G+AVDW+ NLYWT+ G R TI +RL+
Sbjct: 576 TSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQS 635
Query: 1462 RKVLINNSLDEPRAIAVFPRKGYLFWTDW------GHIAKIERANLDGSERKVLINTDLG 1515
RK L+ + PR I V P G+++WTDW + +IE+A +DG R++ + + +
Sbjct: 636 RKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKML 695
Query: 1516 WPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQDRWIYWTD 1573
WPNGLTLD+ T +YW DA+ D IE LNG R+++ S ++HPF L+ +++WTD
Sbjct: 696 WPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTD 755
Query: 1574 WQTKSIQRVDKYSGRNKETVLANVE--GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFAR 1631
+ SI ++D + E L E L + + P++Q G N C VNNGGC+ LC A
Sbjct: 756 YMNGSIFQLDLIT---SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAI 812
Query: 1632 ASDFVCACPD----EPDSRPCSLVPGLVPP 1657
VCAC D + + C+ PG P
Sbjct: 813 PGGRVCACADNQLLDENGTTCTFNPGEALP 842
Score = 224 bits (571), Expect = 6e-58
Identities = 126/344 (36%), Positives = 195/344 (56%), Gaps = 17/344 (4%)
Query: 709 CTHLCLPSGQNYTCACPTGF--RKISSHACAQSLDK--FLLFARRMDIRRISFDTEDLSD 764
C+ C+ + Y C C G+ + + + C D+ FL+ A +IR+IS D S+
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDG---SN 3034
Query: 765 DVIPLADVRSAVALDWDSRDDHVYWTDVSTDT---ISRAKWDGTGQEVVVDTSLESPAGL 821
+ + + +A+D+D R++ +YW D S I+R +G+ +VV +T++ P L
Sbjct: 3035 YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 3092
Query: 822 AIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS 881
A+DW+ LYW+D IEV+ +G T+L+ + L PRD+ ++P GY+YW D
Sbjct: 3093 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEY 3152
Query: 882 PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI 941
P I R GMD + + V+I + ++ P L IDY ++RLYWAD IEF+ +DGS R +
Sbjct: 3153 PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKVP 3210
Query: 942 GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR-RRP 1000
+P LTL+ + IYWTD +TKS+ A + +G DR +L + + DI V+H R+P
Sbjct: 3211 NQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQP 3270
Query: 1001 PVSTP-CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
VS C + NGGCSHLCL +P + +C CPT L +D +TC
Sbjct: 3271 DVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRTC 3313
Score = 199 bits (506), Expect = 2e-50
Identities = 130/393 (33%), Positives = 195/393 (49%), Gaps = 62/393 (15%)
Query: 1311 NKCGSRN-GGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--------------------- 1348
N+C S+ GCS C P + C C G QLK DGKTC
Sbjct: 2928 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 2987
Query: 1349 ---------------DPS-------PETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
+P+ E +L+ + IR+IS D S++T + LNN
Sbjct: 2988 TYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLK---QGLNN 3044
Query: 1387 VISLDYDSVDGKVYYTDVFL---DVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLY 1443
VI++D+D + +Y+ D I R LNGS+++ V + LAVDW+ +NLY
Sbjct: 3045 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 3102
Query: 1444 WTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDG 1503
W+DT + IE S+L+G +L++ L PR +++ P+ GYL+W D I R +DG
Sbjct: 3103 WSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDG 3162
Query: 1504 SERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLR-QVLVSHVSHPFAL 1562
+ + V+I T + P LT+DY RR+YW D + IE ++++G R +V + AL
Sbjct: 3163 TNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIAL 3220
Query: 1563 TQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVN 1620
T + +IYWTD +TKS+ R K SG ++ +++ + + DI V RQ + C +N
Sbjct: 3221 TLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMIN 3280
Query: 1621 NGGCTHLC-FARASDFVCACPDE----PDSRPC 1648
NGGC+HLC A CACP D+R C
Sbjct: 3281 NGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
Score = 184 bits (466), Expect = 9e-46
Identities = 117/346 (33%), Positives = 183/346 (52%), Gaps = 20/346 (5%)
Query: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNS---FLIFARRIDIRMVSLDIPYF 1069
CS C+ + + C C G + D ++ FLI A +IR +S D +
Sbjct: 2978 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035
Query: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTL---HRISRANLDGSQHEDIITTGLQTT 1126
+ +N N IAI D +E +YW DS+ RI+R L+GS + + T +
Sbjct: 3036 TLLKQGLN----NVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVP-- 3089
Query: 1127 DGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186
+ LAVD IG+ +YW+DT IEV L+G +LV + L PR + L + G++YW D
Sbjct: 3090 NALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDC 3149
Query: 1187 GENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRH 1246
E + R GMDG++++V+I + P LT+D + +L WAD + IE ++++G++RH
Sbjct: 3150 CEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRH 3207
Query: 1247 TLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVD-- 1303
+ + + LTL + YIYWTD +T+S+ RA K +G++ + + + + D+Q
Sbjct: 3208 KVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSY 3267
Query: 1304 RAQPLGFNKCGSRNGGCSHLCLPRP-SGFSCACPTGIQLKGDGKTC 1348
R + + C NGGCSHLCL P +CACPT L D +TC
Sbjct: 3268 RQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
Score = 146 bits (368), Expect = 2e-34
Identities = 91/294 (30%), Positives = 128/294 (43%), Gaps = 64/294 (21%)
Query: 191 CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRC 250
C +F+C +CI + CD DDCGD SDE D C+ G F C +GLC + C
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC 3376
Query: 251 DGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWRCDGEDDCADNSDEENC-ENTG 308
DG+ DC D SDE NC T +C + QF+C + +C+ ++ RC+G+DDC D DE +C EN+
Sbjct: 3377 DGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
Query: 309 SPQ------------------------------------CALDQFLCWNGRCIGQRKLCN 332
SP C +F C N CI C+
Sbjct: 3437 SPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCD 3496
Query: 333 GVNDCGDNSDESPQQNCRPRTGEENCNVN-----NGGCAQKCQMVRGAVQCTCHTGYRLT 387
NDC DNSDE +NC+P+T C + NG C G C +
Sbjct: 3497 SQNDCSDNSDE---ENCKPQT----CTLKDFLCANGDCVSSRFWCDGDFDCADGS----- 3544
Query: 388 EDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYE---LRPDRRSCKALGP 438
D C+ C+++ + C+N + W G+E D +SC+ P
Sbjct: 3545 -DERNCE--TSCSKDQF---RCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
Score = 125 bits (314), Expect = 4e-28
Identities = 105/378 (27%), Positives = 160/378 (42%), Gaps = 39/378 (10%)
Query: 699 KNR-CGDNN-----GGCTHLCLPSGQNYTCACPTGFRKISSHACAQ-SLDKFLLFARRMD 751
KNR C D N G C+H C+ +Y C C F++ ++ A+ S D+ L A D
Sbjct: 3838 KNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTD 3897
Query: 752 IRRISFDTEDLSD--DVIPLADVRSAVALDWDSRDDHVYW-TDVSTDTISRAKWDGTGQE 808
I + D + + +D + D + W T + I + G +
Sbjct: 3898 ILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKR 3957
Query: 809 V----VVDTSLESPAGLAIDWVTNKLYWTDAGTDR---------------IEVANTDGSM 849
++ + P +A+DWV +YWTD I V +G
Sbjct: 3958 QANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPN 4017
Query: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLA 909
T L+ P I V P G MYWT G IE A MD + R++++ NL P GLA
Sbjct: 4018 CTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLA 4077
Query: 910 IDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKS 967
+DY S+R+YWAD + I DGS V + S+ L HP + ++ + IY
Sbjct: 4078 VDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNG 4136
Query: 968 IQSADRLTGLDRETLQENLENLMDIHVFHR-RRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
+ + E L N++ + + HR ++ + PC + C LCL NPSG
Sbjct: 4137 VFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLL--NPSGA 4192
Query: 1027 SCTCPTGINLLSDGKTCS 1044
+C CP G L++ TC+
Sbjct: 4193 TCVCPEGKYLING--TCN 4208
Score = 122 bits (307), Expect = 3e-27
Identities = 90/287 (31%), Positives = 119/287 (41%), Gaps = 37/287 (12%)
Query: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE---ENCPSAVPAPPCNL- 193
N C++ C+ C D + + G +C D E+ CN
Sbjct: 2458 NDTNSCELSPCALLNGGCHDLCLLTPN----GRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
Query: 194 EEFQCAYGRCILDIYHCDGDDDCGDWSDESDC-SSHQPCRSGEFMCDSGLCINAGWRCDG 252
EF+C G CI CDG C D SDE ++ CR G C + CI G CDG
Sbjct: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDG 2573
Query: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQ- 311
+ DC D SDE +C S C +FRC G C+ S RC+ DCAD SDE+NC NT
Sbjct: 2574 ENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHF 2633
Query: 312 ----CALDQFLCWNGR--CIGQRKLCNGVNDCGDNSDE--SPQQNCRPRTGEENCNVNNG 363
F+ N C+ +C+G NDCGD SDE P QN + + E + +G
Sbjct: 2634 YKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN-KHKCEENYFSCPSG 2692
Query: 364 GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410
C + G C EDG +E +C C+
Sbjct: 2693 RCILNTWICDGQKDC---------EDGR---------DEFHCDSSCS 2721
Score = 119 bits (297), Expect = 4e-26
Identities = 95/373 (25%), Positives = 159/373 (42%), Gaps = 61/373 (16%)
Query: 1320 CSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPET------------------------Y 1355
C + C + C C G ++ DG++C E Y
Sbjct: 125 CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGY 184
Query: 1356 LLFSSRGSIRRISLDTSDHTDV-------HVPVPELNNVISLDYDSVDGKVYYTDVF--- 1405
L+ S + ++ +D + + V LN SV+G +T F
Sbjct: 185 LMQPDNRSC-KAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYN 243
Query: 1406 ---------------LDVIRRADLNGSNMETVIG--RGLKTTDGLAVDWVARNLYWTDTG 1448
L I+ G E I + +A+DW+ RNLY+ D
Sbjct: 244 EDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHV 303
Query: 1449 RNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKV 1508
+ I +GS LI+ L P+AIAV P G LF+TD+G++AK+ER ++DG R
Sbjct: 304 GDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTR 363
Query: 1509 LINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQD 1566
+I++ P L LD + +YWVD +LD + D GK R ++ V H + +T +
Sbjct: 364 IIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFE 423
Query: 1567 RWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVN---- 1620
++Y T+ +I R+++++G + + L +E I + + Q ++AC V+
Sbjct: 424 DYLYATNSDNYNIVRINRFNGTDIHS-LIKIENAWGIRIYQKRTQPTVRSHACEVDPYGM 482
Query: 1621 NGGCTHLCFARAS 1633
GGC+H+C +S
Sbjct: 483 PGGCSHICLLSSS 495
Score = 116 bits (291), Expect = 2e-25
Identities = 93/352 (26%), Positives = 150/352 (42%), Gaps = 33/352 (9%)
Query: 1318 GGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLD---TSDH 1374
G CSH C+ + C C Q + + + S + L ++ I + DH
Sbjct: 3852 GTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 3911
Query: 1375 TDVHVPVPELNNVISLD-YDSVDGKVYYTD-----VFLDVIRRADLNGSNMETVIGRGLK 1428
+ + + + +D Y D ++ T +F I + +N + +
Sbjct: 3912 QQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKR 3970
Query: 1429 TTDGLAVDWVARNLYWTDTGRN---------------TIEASRLDGSCRKVLINNSLDEP 1473
D +AVDWVA N+YWTD R +I +L+G L+ N EP
Sbjct: 3971 PRD-IAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 4029
Query: 1474 RAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVD 1533
AIAV P++G ++WT G + IE A +DG+ R++L+ +L P GL +DY + RIYW D
Sbjct: 4030 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 4089
Query: 1534 AHLDRIESADLNGKLRQVLVSH---VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
L I S +G V VS + HP + + +IY + RV K+ +
Sbjct: 4090 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSV 4148
Query: 1591 ETVLANVEGLMDIIVVSPQRQTG-TNACGVNNGGCTHLCFARASDFVCACPD 1641
E + N++ +++ +Q N C + C LC S C CP+
Sbjct: 4149 EYLALNIDKTKGVLISHRYKQLDLPNPC--LDLACEFLCLLNPSGATCVCPE 4198
Score = 104 bits (259), Expect = 9e-22
Identities = 66/193 (34%), Positives = 93/193 (48%), Gaps = 23/193 (11%)
Query: 232 RSGEFMC--DSGLCINAGWRCDGDADC---DDQSDERNCTTS----------MCTAEQFR 276
+ G+ MC ++G C G C D+Q + N TT +C A +FR
Sbjct: 792 QQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFR 851
Query: 277 CHSGRCVRLSWRCDGEDDCADNSDEE--NCENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
C + C++ W+CDG+DDC D SDE+ NC N P DQF C N RCI +R LC+G
Sbjct: 852 CKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPD---DQFKCQNNRCIPKRWLCDGA 908
Query: 335 NDCGDNSDESPQQNCRPRTGE-ENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
NDCG N DES Q C RT + + + NG C + + C T + + TC
Sbjct: 909 NDCGSNEDES-NQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTC 967
Query: 394 QDVNE-CAEEGYC 405
+ + + + G C
Sbjct: 968 EPLTQFVCKSGRC 980
Score = 101 bits (252), Expect = 6e-21
Identities = 90/354 (25%), Positives = 136/354 (38%), Gaps = 32/354 (9%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFA 1070
G CSH C+ + C C ++ + L A DI Y
Sbjct: 3852 GTCSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909
Query: 1071 DVVVPINITMKNTIAIGVDP--QEGKVYWSDS-----TLHRISRANLDGSQHEDIITTGL 1123
D +I + I G+D Q + WS ++ + +I
Sbjct: 3910 DHQQISHIEHNSRIT-GMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEF 3968
Query: 1124 QTTDGLAVDAIGRKVYWTDTGTNR---------------IEVGNLDGSMRKVLVWQNLDS 1168
+ +AVD + +YWTD I VG L+G L+
Sbjct: 3969 KRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGE 4028
Query: 1169 PRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWA 1228
P AI + + G MYWT G+++ +E + MDG+ R +L+ NL P GL VD S ++ WA
Sbjct: 4029 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWA 4088
Query: 1229 DAHTERIEAADLNGANRHTLVSPVQ---HPYGLTLLDSYIYWTDWQTRSIHRADKGTGSN 1285
D I + +G+N VS Q HP+ + + + YIY + R K +
Sbjct: 4089 DFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGS 4147
Query: 1286 VILVRSNLPGLMDMQAVDRAQPLGF-NKCGSRNGGCSHLCLPRPSGFSCACPTG 1338
V + N+ + R + L N C + C LCL PSG +C CP G
Sbjct: 4148 VEYLALNIDKTKGVLISHRYKQLDLPNPC--LDLACEFLCLLNPSGATCVCPEG 4199
Score = 59.3 bits (142), Expect = 3e-08
Identities = 41/128 (32%), Positives = 58/128 (45%), Gaps = 16/128 (12%)
Query: 71 CSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDE--QDCPPR---ECEEDEFPC-QNGYCI 123
C P +F C D+ C+ +SW+CDGD DC DDSDE CP +C + C C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 124 RSLWHCDGDNDCGDNSDE--QCDMRKCSDKEFRCSDGSCIAEH---WYC-DGDTDCKDG- 176
C+G DC D DE C + ++ C + + YC DG +DG
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
Query: 177 --SDEENC 182
D++ C
Sbjct: 152 SCKDQDEC 159
Score = 57.4 bits (137), Expect = 1e-07
Identities = 45/149 (30%), Positives = 58/149 (38%), Gaps = 30/149 (20%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTC-SPLDFHC------- 78
C F C TC+ W CDGD DC D SDE L TC ++ C
Sbjct: 32 CDPGEFLCH----DHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIAC 84
Query: 79 -DNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYC------IRSLWHCDG 131
KC+ S +C+G DC D DE C+E CQ C +R+ C
Sbjct: 85 LGTNKCVHLSQLCNGVLDCPDGYDE----GVHCQELLSNCQQLNCQYKCTMVRNSTRC-- 138
Query: 132 DNDCGDNSDEQCDMRKCSDKEFRCSDGSC 160
C D + D R C D++ G+C
Sbjct: 139 --YCEDGFEITEDGRSCKDQDECAVYGTC 165
Score = 40.4 bits (93), Expect = 0.017
Identities = 59/247 (23%), Positives = 83/247 (33%), Gaps = 58/247 (23%)
Query: 32 FTCAVSALGE-CTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVC 90
F C ++ G C C ++ +G C D S D TC + G+CI
Sbjct: 4183 FLCLLNPSGATCVCPEGKYLINGT--CNDDSLLDDSCKLTCE------NGGRCILNE--- 4231
Query: 91 DGDNDCE--DDSDEQDCPPRECEEDEFPCQNG-YCIRSLWHCDGDNDCGDNSDEQCDMRK 147
GD C + C C CQNG C+ S+ + + C
Sbjct: 4232 KGDLRCHCWPSYSGERCEVNHCSNY---CQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV 4288
Query: 148 CSDKEFRCSDGSCIAE-----------------------HWYCDGDTDCK---DGSDEEN 181
C D F + G+CI H YC C DGS E
Sbjct: 4289 CED--FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECV 4346
Query: 182 CPSAVPAPPCNLEE-FQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS 240
CP+ P C +++ +C G CI++ D +C + S C +CD
Sbjct: 4347 CPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ----------LCD- 4395
Query: 241 GLCINAG 247
G C N G
Sbjct: 4396 GYCYNGG 4402
Score = 39.7 bits (91), Expect = 0.028
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 1/45 (2%)
Query: 350 RPRTGEENCNVNNGGCAQKCQMVRGAVQ-CTCHTGYRLTEDGHTC 393
+P + C +NNGGC+ C + G C C T + L D TC
Sbjct: 3269 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
Score = 38.9 bits (89), Expect = 0.048
Identities = 72/314 (22%), Positives = 100/314 (31%), Gaps = 86/314 (27%)
Query: 50 QCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRE 109
Q D N C D + E C+L +P C C ++ +G C DDS D
Sbjct: 4169 QLDLPNPCLDLACEFLCLL---NPSGATC---VCPEGKYLINGT--CNDDSLLDDSCKLT 4220
Query: 110 CEEDEFPCQNGYCIRSLWHCDGDNDCG---DNSDEQCDMRKCSDKEFRCSDGSCIAEHWY 166
CE G CI + GD C S E+C++ CS+ C +G
Sbjct: 4221 CEN------GGRCILNE---KGDLRCHCWPSYSGERCEVNHCSNY---CQNGGTCVPSVL 4268
Query: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDI-----YHCDGD---DDCGD 218
C G NC V E+F G CI+ HC + D C
Sbjct: 4269 GRPTCSCALGFTGPNCGKTV------CEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQY 4322
Query: 219 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADC--DDQSDERNCTTSMCTAEQFR 276
+ C + + C G+ DG +C + + C C R
Sbjct: 4323 YVCHHYCVNSESCTIGD---------------DGSVECVCPTRYEGPKCEVDKCV----R 4363
Query: 277 CHSGRCVRLSWRCDGEDDCADNSDEEN--CENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
CH G C+ N D E+ C C NG+ +LC+G
Sbjct: 4364 CHGGHCII-------------NKDSEDIFCN-------------CTNGKIASSCQLCDGY 4397
Query: 335 NDCGDNSDESPQQN 348
G P+ N
Sbjct: 4398 CYNGGTCQLDPETN 4411
Score = 32.7 bits (73), Expect = 3.5
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 5/40 (12%)
Query: 1617 CGVNNGGCTHLC-FARASDFVCACPD----EPDSRPCSLV 1651
C +NNGGC++ C VC+CP+ D++ C +V
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV 1215
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 1065 bits (2755), Expect = 0.0
Identities = 614/1686 (36%), Positives = 904/1686 (53%), Gaps = 93/1686 (5%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC--ILPTCSPLDFHCDN 80
P CG F C C+P + CDG +DC D+SDE C + TCS F C +
Sbjct: 1022 PTEQCGLFSFPCKNGR-----CVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGH 1076
Query: 81 GKCIRRSWVCDGDNDCEDDSDEQDCP---PRECEEDEFPCQNGYCIRSLWHCDGDNDCGD 137
G+CI W CD NDC D SDE +CP P C + ++ C N CI W CD DNDCGD
Sbjct: 1077 GECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGD 1136
Query: 138 NSDEQ-CDMRK-CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEE 195
SDE+ C+ + C +F C + CI + CDGD DC DGSDE C C +
Sbjct: 1137 GSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC-----VLNCTASQ 1191
Query: 196 FQCAYG-RCILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMC-DSGLCINAGWRCD 251
F+CA G +CI CDG DC D SDE+ C + P C S EF C + G+CI W CD
Sbjct: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECD 1251
Query: 252 GDADCDDQSDERN-CTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSP 310
G DC SDE N C C + F C +G C+ +W CD ++DC D SDE++C T
Sbjct: 1252 GHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP-TQPF 1310
Query: 311 QCALDQFLCWNGR-CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKC 369
+C Q+ C C+ +C+G+ DC + +DESP N +C+ NGGC +C
Sbjct: 1311 RCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCN------GNSCSDFNGGCTHEC 1364
Query: 370 QMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPD 429
+C C G+ L D TC+D++EC G CSQ C N G+F+C C+TGY L D
Sbjct: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424
Query: 430 RRSCKALGPEPVLLFA---NRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSD 486
R+CK E +LL N+I V L+ N +A+DF +FWSD
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 487 VTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRK 546
T + A NG++ V + + +A+DWV LYWTD IEV+ +DG+HR
Sbjct: 1485 ATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRT 1544
Query: 547 VLLWQNLEKPRAIALHPM--EGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLT 604
VL+ +NL PR +AL P E ++W+DWG+ PRIE +SMDGS R +I +FWP GLT
Sbjct: 1545 VLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLT 1604
Query: 605 IDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGL--PHPFAITVFEDSLYWTDWHTKS 662
IDY R +Y++D+ ++ + +G HR+ VI+ L HP+A+T+FEDS+YWTD T+
Sbjct: 1605 IDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRR 1664
Query: 663 INSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN--- 719
+ ANK+ G NQ ++ + +P+ I +HP +QP N C + C+HLCL S Q
Sbjct: 1665 VMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGPHF 1722
Query: 720 YTCACPTGFRKISSHA-CAQSLDKFLLFARRMDIRRISFDTEDLSDD-VIPLADVRSAVA 777
Y+C CP+G+ C + FL+ R+ I IS + E S+D ++P+A +++ +
Sbjct: 1723 YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLD 1782
Query: 778 LDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPA-GLAIDWVTNKLYWTDAG 836
+++D + ++YW + + I R K DGT + V S+ P+ LA+DW++ LY T+
Sbjct: 1783 VEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPR 1841
Query: 837 TDRIEVANTDGSMR---TVLIWEN----LDRPRDIVVEPMGGYMYW----TDWGASPKIE 885
T IEV G +R T++ + + P I V+P G +YW TD G KI
Sbjct: 1842 TQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIA 1901
Query: 886 RAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 945
A MD + + + + NL + +D Q+LYWA G IE +DG+ R +L+ QL
Sbjct: 1902 SANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV-HQL 1960
Query: 946 PHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTP 1005
HP+G+ ++ +Y+TD Q + I+ D+ TG ++ L++N+ NL + V+HRR S+
Sbjct: 1961 SHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSN 2020
Query: 1006 -CAMENGGCSHLCLRSPNPSG-FSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVS 1063
C+ C +CL P P G FSC C TG L D ++CSP NSF++ + IR S
Sbjct: 2021 GCSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSP-YNSFIVVSMLSAIRGFS 2077
Query: 1064 LDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSD-----STLHRISRANLDGSQHEDI 1118
L++ ++ +VP+ +N + + VD G +YW D ++ + I R DGS +I
Sbjct: 2078 LELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNI 2137
Query: 1119 ITTGLQTTD--GLAVDAIGRKVYWTDTGTNR--IEVGNLDGSMRKVLVWQNLDSPRAIVL 1174
+T G+ G+AVD + +Y+T+ + IEV ++ + R+VL+ +D PR IV+
Sbjct: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197
Query: 1175 YHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTER 1234
+ +++W D+G+ K+ERS +D ++R VL++ + P GL VD++ + W D +
Sbjct: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257
Query: 1235 IEAADLNGANRHTLV--SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV--ILVR 1290
I +NG N + S PYG+T+ ++ I W D + I +A K + ++R
Sbjct: 2258 IARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIR 2317
Query: 1291 SNLPGLMDMQAVDR-AQP-----LGFNKCGSRNGGCSHLCLPRPSGFS--CACPTGIQLK 1342
N+ L D+ D+ QP + N C NGGCSHLC P + C C G L+
Sbjct: 2318 DNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGT-LQ 2376
Query: 1343 GDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYT 1402
DGK C S E +L+F+ S+R + LD +H+ + V+SLDYDSV ++Y+T
Sbjct: 2377 SDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFT 2436
Query: 1403 DVFLDVIRRADL----NGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLD 1458
+ + +G + TVI G+ T DG+A DW+ R +Y++D I + D
Sbjct: 2437 QNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAED 2496
Query: 1459 GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPN 1518
GS R V+ + +PRAI + P +GYL+W DW AKIERA L G+ R ++N+ L P+
Sbjct: 2497 GSNRTVIAR--VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPS 2554
Query: 1519 GLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKS 1578
GLTLDY+ +YWVDA L RIE + L G R+V+V+ H F LT ++IYWTD T+
Sbjct: 2555 GLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQR 2614
Query: 1579 IQRVDKYSGRNKETVLANVEGLMDII--VVSPQRQTGTNACGVNNGGCTHLCFARASDFV 1636
I R +KY G + + N+ I VV Q+Q N C NGGC+H+C +
Sbjct: 2615 IYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAE 2674
Query: 1637 CACPDE 1642
C CP E
Sbjct: 2675 CQCPHE 2680
Score = 673 bits (1736), Expect = 0.0
Identities = 362/1010 (35%), Positives = 537/1010 (53%), Gaps = 47/1010 (4%)
Query: 66 CILPT----CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN-G 120
C+ P C F C +G CI W CDG DC DD+DE C C++ F CQ+ G
Sbjct: 19 CLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEG 78
Query: 121 YCIRSLWHCDGDNDCGDNSDEQ--CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
CI + W CD D DC D SDE+ C CS + CS+G CI + CD DC DG+D
Sbjct: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGAD 138
Query: 179 EENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC 238
E +C P C E+ C G C CD DC D SDE +C+ + C EF C
Sbjct: 139 ENDCQY----PTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT--EICLHNEFSC 190
Query: 239 DSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADN 298
+G CI + CD D DC D SDE C C QF C SGRC+ +W CDGEDDC DN
Sbjct: 191 GNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDN 250
Query: 299 SDEENCENTGSP--QCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGE 355
DE+ CE+ +C+ ++ C +GRCI K+C+G+ DC DE+ +
Sbjct: 251 GDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK-YCSM 309
Query: 356 ENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTE-DGHTCQDVNECAEEGYCSQGCTNSEG 414
C+ N C +C C C GY + D TC + ++C G C Q C + G
Sbjct: 310 TLCSALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPG 367
Query: 415 AFQCWCETGYELRPDRRSCKALGP--EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIA 472
C CE GY L + CKA E ++F+N D+ H + +L+ + +A
Sbjct: 368 RHLCHCEEGYILERGQY-CKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVA 426
Query: 473 LD--FHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDS 530
+ FH+ + VFW+D +++ ++NG N++EV++ +E+P LAVDWV++K+Y ++
Sbjct: 427 VGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVET 486
Query: 531 GTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW---GNTPRIEASSMDGS 587
+RI++ NLDG++R L+ +NL PR IA+ P G ++++DW P++E + MDGS
Sbjct: 487 KVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGS 546
Query: 588 GRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFA 645
R+ + T L WP G+T+D +R+YWVD++ IE DG RK V+ G +PHPF
Sbjct: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
Query: 646 ITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN 705
+++FE +++TDW ++ ANKFT N ++ P + H RQP N C DN
Sbjct: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
Query: 706 NGGCTHLCLPS------GQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDT 759
NGGC +C+ S G + C C GF+ + ++ FL+F+ ++ IR I F
Sbjct: 667 NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTL 726
Query: 760 EDLSDDVIPLADVRS-AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESP 818
D ++P++ S V +D+D++D ++++D+S I + K DGTG+E++ +E+
Sbjct: 727 STQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENV 786
Query: 819 AGLAIDWVTNKLYWTDAGTDRIEVAN-TDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTD 877
LA DW++ LYWTD+ I V D + RTV+ + L+ PR +VV P GY+++TD
Sbjct: 787 ESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYLFFTD 844
Query: 878 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDG-SK 936
W KI RA D S +I++ L WPNGLAID+ + RLYW DA IE + DG +
Sbjct: 845 WFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 904
Query: 937 RKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH 996
R++ Q+ HPFGL ++GE +++TDW+ +I + G + ++ + ++ + +
Sbjct: 905 RRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYD 964
Query: 997 RRRPPVSTPC---AMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
S C NG CSH C PN C CP G+ L S+ TC
Sbjct: 965 VNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV-CGCPYGMRLASNHLTC 1013
Score = 616 bits (1588), Expect = e-176
Identities = 326/812 (40%), Positives = 428/812 (52%), Gaps = 118/812 (14%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDE--DGCILPTCSPLDFHCDNGKCI 84
CG S FTC+ CI +W+CD DNDCGD SDE C L TCSP F C NG+C+
Sbjct: 2700 CGASSFTCSNGR-----CISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCV 2754
Query: 85 RRSWVCDGDNDCEDDSDEQDCPPREC--------------------------------EE 112
+ S+ CD NDC D SDE C R+C +E
Sbjct: 2755 QYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDE 2814
Query: 113 DEFP---CQNGY--------CIRSLWHCDGDNDCGDNSDEQ---CDMRKCSDKEFRCSDG 158
P CQ+GY CI ++ CDGDNDCGDNSDE C CS EF+C+ G
Sbjct: 2815 KNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG 2874
Query: 159 SCIAEHWYCDGDTDCKDGSDEE-NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCG 217
CI +HWYCD +TDC D SDE +C + C +EF+C GRCI + CDGD+DCG
Sbjct: 2875 RCIPQHWYCDQETDCFDASDEPASCGHSERT--CLADEFKCDGGRCIPSEWICDGDNDCG 2932
Query: 218 DWSDES---DCSSHQPCRSGEFMCDSGL-----CINAGWRCDGDADCDDQSDE-RNCTTS 268
D SDE C + Q C EF+C + CI W CDGD DC D DE +NCT
Sbjct: 2933 DMSDEDKRHQCQN-QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRR 2991
Query: 269 MCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQR 328
C+ +F C G C+ +RCD +DC D SDE C C +QF C NGRCI +
Sbjct: 2992 TCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQ---TCQQNQFTCQNGRCISKT 3048
Query: 329 KLCNGVNDCGDNSDE------SPQQNCRPR-------------------------TGEEN 357
+C+ NDCGD SDE +P+ C P + E+
Sbjct: 3049 FVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKG 3108
Query: 358 CNVNN------GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY-CSQGCT 410
C +N GC C + C+C GY+L D TC D++EC E + CSQ C
Sbjct: 3109 CGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCE 3168
Query: 411 NSEGAFQCWCETGYELRPDRRSCKALGP-EPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469
N G++ C C GY PD ++C+ EP L+F+NR +R + Y+L+L L+N
Sbjct: 3169 NVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDN 3228
Query: 470 AIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTD 529
+ALDF + ++W D I R LN +N E +++ L + LAVDWV KLYW D
Sbjct: 3229 VVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLD 3288
Query: 530 SGTSRIEVANLDGAHRKVLLWQNLE--------KPRAIALHPMEGTIYWTDWGNTPRIEA 581
+ + V++L+G HR++L ++ PR +ALHP G +YW DWG+ I
Sbjct: 3289 ARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGR 3348
Query: 582 SSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLP 641
MDG+ + +I T L WPNG+TIDY +YW DA IE ++L+G HR V LP
Sbjct: 3349 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP 3408
Query: 642 HPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNR 701
HPFAIT+FED++YWTDW+T+++ NK+ G N++ + N H P DIH HP RQP N
Sbjct: 3409 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 3468
Query: 702 CGDNNGGCTHLCL--PSGQNYTCACPTGFRKI 731
CG NNGGC+HLCL P G+ +TC CP FR +
Sbjct: 3469 CGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
Score = 483 bits (1243), Expect = e-136
Identities = 288/817 (35%), Positives = 394/817 (48%), Gaps = 114/817 (13%)
Query: 10 LGALLCAHGLASSPECACGRSHFTC---------------AVSALGECT---CIPAQWQC 51
LG C+ G +SP+ C +H C S +C CIP WQC
Sbjct: 3555 LGQFQCSDGNCTSPQTLCN-AHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQC 3613
Query: 52 DGDNDCGDHSDEDG--CILPTCSPLDFHCDNGKCIRRSWVCDGDNDC------------- 96
D NDC D+SDED C TC P F C NG+CI ++W CD DNDC
Sbjct: 3614 DTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMS 3673
Query: 97 --------------------------------EDDSDEQDCPPRECEE-DEFPCQNGYCI 123
D+SDEQ C R C +F C+N +CI
Sbjct: 3674 SAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCI 3733
Query: 124 RSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
W CDG NDCGDNSDE+ C R+C++ EFRC + CI W CD DC D SDE +C
Sbjct: 3734 PLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Query: 183 PSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP----CRSGEFMC 238
C+ E FQC G C+ CDG DC D SDE+DC + P C++ F C
Sbjct: 3794 EMRT----CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFEC 3849
Query: 239 DSGLCINAGWRCDGDADCDDQSDERN--CTTSMCTA-EQFRCHSGRCVRLSWRCDGEDDC 295
+ +CI W+CDGD DC D SDE C C + +FRC + RC+ C+G DDC
Sbjct: 3850 KNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDC 3909
Query: 296 ADNSDE--ENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRT 353
D +DE E+C C ++ C NG CI +C+ +DCGD SDE + RT
Sbjct: 3910 GDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERT 3969
Query: 354 GEENCNVNNGGCAQKC-QMVRGAVQCTCHTGYRLTE-DGHTCQDVNECAEEGYCSQGCTN 411
EN C Q C Q+ G C+C G+ D +C D+NEC + G C Q C N
Sbjct: 3970 CAENI------CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRN 4023
Query: 412 SEGAFQCWCETGYELRPDR--RSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469
++G+++C C G+ DR + C A G P+LL + + IR+ ++ L + E
Sbjct: 4024 TKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEY 4083
Query: 470 AIALDFHHRRELVFWSDV---------TLDRILRANL-----NGSNVEEVVSTGLE---S 512
A+D+ + + S V I RA + +N+ + V L+
Sbjct: 4084 IQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQ 4143
Query: 513 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 572
P G+AVDWV +YW+D RIEVA LDG +RK L+ +L++P AIA++P G ++WTD
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 573 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR-RMYWVDAKHHVIERANLDGSH 631
WG P+IE++ M+G R I+ L WP GL+IDY R+YW D K VIE DG+
Sbjct: 4204 WGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTD 4263
Query: 632 RKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLH 691
R+ + + + +P+++ +FED LYW + NKF +E + + H
Sbjct: 4264 RRVIAKEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH 4322
Query: 692 PQR-QPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTG 727
R + N C C+HLCL Y+CACP G
Sbjct: 4323 QLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQG 4356
Score = 390 bits (1003), Expect = e-108
Identities = 216/667 (32%), Positives = 356/667 (53%), Gaps = 26/667 (3%)
Query: 707 GGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKF----LLFARRMDIRRISFDTEDL 762
G C C + C C G+ C + D F ++F+ D+ + D
Sbjct: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKAN-DSFGEASIIFSNGRDL--LIGDIHGR 412
Query: 763 SDDVIPLADVRS-AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGL 821
S ++ + R AV + + V+WTD + + +G + V++ S+E+P L
Sbjct: 413 SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENL 472
Query: 822 AIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW--- 878
A+DWV NK+Y + +RI++ N DGS R LI ENL PR I V+P GY++++DW
Sbjct: 473 AVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESL 532
Query: 879 GASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRK 938
PK+ERA MD S R+ ++ + L WP G+ +D S+R+YW D+ IE DG +RK
Sbjct: 533 SGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRK 592
Query: 939 VLI--GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH 996
++ GS +PHPFG++L+ ++++TDW ++ A++ T + + + + V+H
Sbjct: 593 TVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYH 652
Query: 997 RRRPPVST-PCAMENGGCSHLCLRSPNPS----GFSCTCPTGINLLSDGKTCSPGMNSFL 1051
R P +T PC NGGC +C+ S GF C C G L +D + C N FL
Sbjct: 653 SLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN-FL 711
Query: 1052 IFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLD 1111
IF+ ++ IR + + DV+VP++ + I D Q+ +++SD + H I + +D
Sbjct: 712 IFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKID 771
Query: 1112 GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRA 1171
G+ E + ++ + LA D I + +YWTD+ I V L R+ +V Q L++PR+
Sbjct: 772 GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRS 830
Query: 1172 IVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAH 1231
+V++ G++++TDW AK+ R+ DGS +IN LGWPNGL +D A+S+L W DA+
Sbjct: 831 VVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAY 890
Query: 1232 TERIEAADLNGANRHTL--VSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILV 1289
++IE + +G +R L + + HP+GL + ++++TDW+ +I R K G + ++
Sbjct: 891 FDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVI 950
Query: 1290 RSNLPGLMDMQAVDRAQPLGFNKCGSR---NGGCSHLCLPRPSGFS-CACPTGIQLKGDG 1345
RS + ++ +++ D G N C NG CSH C P P+ C CP G++L +
Sbjct: 951 RSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNH 1010
Query: 1346 KTCDPSP 1352
TC+ P
Sbjct: 1011 LTCEGDP 1017
Score = 361 bits (927), Expect = 3e-99
Identities = 212/654 (32%), Positives = 348/654 (53%), Gaps = 32/654 (4%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF----LIFARRIDIRMVSLDI 1066
G C C P C C G +L G+ C +SF +IF+ D+ + +
Sbjct: 356 GICDQKC--ESRPGRHLCHCEEGY-ILERGQYCKAN-DSFGEASIIFSNGRDLLIGDIHG 411
Query: 1067 PYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTT 1126
F +V N + +A Q +V+W+D+ +++ +++G ++++ ++T
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQ--RVFWTDTVQNKVFSVDINGLNIQEVLNVSVETP 469
Query: 1127 DGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186
+ LAVD + K+Y +T NRI++ NLDGS R L+ +NL PR I + +G+++++DW
Sbjct: 470 ENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDW 529
Query: 1187 GE---NAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGA 1243
KLER+ MDGS+R L+ LGWP G+T+D S ++ W D+ + IE +G
Sbjct: 530 ESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGI 589
Query: 1244 NRHTLV---SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV-ILVRSNLPGLMDM 1299
R T+V S + HP+G++L + +++TDW ++ +A+K T +N + +++L
Sbjct: 590 QRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVT 649
Query: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPE 1353
QP N C NGGC +C+ GF C C G QL D + C + +
Sbjct: 650 VYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI-AVQ 708
Query: 1354 TYLLFSSRGSIRRISLDTSDHTDVHVPVP-ELNNVISLDYDSVDGKVYYTDVFLDVIRRA 1412
+L+FSS+ +IR I S DV VPV + + +D+D+ D ++++D+ +I +
Sbjct: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
Query: 1413 DLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472
++G+ E + ++ + LA DW+++NLYWTD+ +I RL R+ ++ L+
Sbjct: 769 KIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQY-LNN 827
Query: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
PR++ V P GYLF+TDW AKI RA DGS +INT LGWPNGL +D+ R+YWV
Sbjct: 828 PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWV 887
Query: 1533 DAHLDRIESADLNGKLRQVL--VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
DA+ D+IE + +G R+ L + ++HPF L +++TDW+ +I RV K G
Sbjct: 888 DAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEM 947
Query: 1591 ETVLANVEGLMDIIVVSPQRQTGTNACGV---NNGGCTHLCFARAS-DFVCACP 1640
+ + + ++ + QTG+NAC NG C+H CF + VC CP
Sbjct: 948 TVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 265 bits (676), Expect = 4e-70
Identities = 138/354 (38%), Positives = 205/354 (57%), Gaps = 17/354 (4%)
Query: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--DPSPETYLLFSS 1360
D+ + ++C CS C + C C G + DGKTC + + E YL+FS+
Sbjct: 3146 DKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSN 3205
Query: 1361 RGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNME 1420
R +R +++D ++ + + L+NV++LD+D V+ ++Y+ D VI R LN +N E
Sbjct: 3206 RYYLRNLTIDGYFYSLI---LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKE 3262
Query: 1421 TVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLI------NNSL--DE 1472
T+I L + LAVDWV+R LYW D + + S L+G R++L NN+ D
Sbjct: 3263 TIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDN 3322
Query: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
PR +A+ P+ GYL+W DWGH A I R +DG+ + V+I+T L WPNG+T+DY +YW
Sbjct: 3323 PRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWA 3382
Query: 1533 DAHLDRIESADLNGKLRQVLVSH-VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKE 1591
DAHL IE +DL G R + + HPFA+T + IYWTDW T+++++ +KY G N++
Sbjct: 3383 DAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
Query: 1592 TVLANVEGLMDIIVVSPQRQT-GTNACGVNNGGCTHLCFAR--ASDFVCACPDE 1642
T++ DI V P RQ +N CG NNGGC+HLC + F C CPD+
Sbjct: 3443 TLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 3496
Score = 259 bits (663), Expect = 1e-68
Identities = 132/355 (37%), Positives = 194/355 (54%), Gaps = 17/355 (4%)
Query: 709 CTHLCLPSGQNYTCACPTGF-RKISSHACAQS--LDKFLLFARRMDIRRISFDTEDLSDD 765
C+ C +Y C C G+ R+ C Q+ ++ +L+F+ R +R ++ D S
Sbjct: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYS-- 3220
Query: 766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
+ L + + VALD+D + +YW D I R + T +E +++ L + LA+DW
Sbjct: 3221 -LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
Query: 826 VTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLD--------RPRDIVVEPMGGYMYWTD 877
V+ KLYW DA D + V++ +G R +L +D PR + + P GY+YW D
Sbjct: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
Query: 878 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
WG I R GMD + + VIIS+ L WPNG+ IDY + LYWADA + IE++ L+G R
Sbjct: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Query: 938 KVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH- 996
+ LPHPF +T++ + IYWTDW T++++ ++ G +R+TL DIHV+H
Sbjct: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
Query: 997 RRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINL--LSDGKTCSPGMNS 1049
R+P VS PC NGGCSHLCL P GF+C CP LS C P +S
Sbjct: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSS 3514
Score = 258 bits (658), Expect = 5e-68
Identities = 139/338 (41%), Positives = 170/338 (50%), Gaps = 21/338 (6%)
Query: 19 LASSPECA--CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG-CILPTCSPLD 75
L+ S C C + F CA + CIP W+CDG DC D SDE C C
Sbjct: 3502 LSGSTYCMPMCSSTQFLCANNE----KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQ 3557
Query: 76 FHCDNGKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQNGYCIRSLWHCDGDN 133
F C +G C +C+ +C D SDE C C+ +E+ C N CI W CD N
Sbjct: 3558 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFN 3617
Query: 134 DCGDNSDEQ---CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE--ENCPSAVPA 188
DC DNSDE C R C +FRC++G CI + W CD D DC D SDE E C S+ A
Sbjct: 3618 DCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSS--A 3675
Query: 189 PPC-NLEEFQCAYG-RCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
C N EF C RCI C+G DDC D SDE C G+F C + CI
Sbjct: 3676 HLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPL 3735
Query: 247 GWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCEN 306
W+CDG DC D SDE NC CT +FRC + +C+ W CD +DC DNSDE +CE
Sbjct: 3736 RWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE- 3794
Query: 307 TGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDES 344
C + F C +G C+ C+G DC D SDE+
Sbjct: 3795 --MRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
Score = 230 bits (586), Expect = 1e-59
Identities = 130/360 (36%), Positives = 195/360 (54%), Gaps = 28/360 (7%)
Query: 1013 CSHLCLRSPNPSG-FSCTCPTGINLLSDGKTCSPGMN--SFLIFARRIDIRMVSLDIPYF 1069
CS C N G + C C G DGKTC N +LIF+ R +R +++D YF
Sbjct: 3163 CSQKC---ENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYF 3218
Query: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGL 1129
+++ + N +A+ D E ++YW D+ I R L+ + E II L + L
Sbjct: 3219 YSLILE---GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESL 3275
Query: 1130 AVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDS--------PRAIVLYHEMGFM 1181
AVD + RK+YW D + + V +L+G R++L +D+ PR + L+ + G++
Sbjct: 3276 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 3335
Query: 1182 YWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLN 1241
YW DWG A + R GMDG++++V+I+ L WPNG+T+D + L WADAH IE +DL
Sbjct: 3336 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 3395
Query: 1242 GANRHTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQ 1300
G +RHT+ + HP+ +T+ + IYWTDW TR++ + +K GSN + + D+
Sbjct: 3396 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
Query: 1301 AV-DRAQPLGFNKCGSRNGGCSHLCLPRP--SGFSCACPTGIQLKGDGKTCDPSPETYLL 1357
QP+ N CG+ NGGCSHLCL +P GF+C CP D +T S TY +
Sbjct: 3456 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP------DDFRTLQLSGSTYCM 3509
Score = 183 bits (465), Expect = 1e-45
Identities = 114/347 (32%), Positives = 143/347 (41%), Gaps = 75/347 (21%)
Query: 119 NGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
N Y + HC DN +C F CS+G CI+E W CD D DC DGSD
Sbjct: 2682 NWYLANNRKHCIVDNG-----------ERCGASSFTCSNGRCISEEWKCDNDNDCGDGSD 2730
Query: 179 EENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC 238
E A+ C+ F CA GRC+ Y CD +DCGD SDE+ C + EFMC
Sbjct: 2731 EMESVCALHT--CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC 2788
Query: 239 ------------------------------------------DSGLCINAGWRCDGDADC 256
+S +CI + CDGD DC
Sbjct: 2789 NNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDC 2848
Query: 257 DDQSDER--NCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCAL 314
D SDE CTT C++ +F+C SGRC+ W CD E DC D SDE C
Sbjct: 2849 GDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLA 2908
Query: 315 DQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRG 374
D+F C GRCI +C+G NDCGD SDE + C+ +NC+ + C R
Sbjct: 2909 DEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQ----NQNCSDSEFLCVNDRPPDR- 2963
Query: 375 AVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTN---SEGAFQC 418
R C +C + +Q CT SE F C
Sbjct: 2964 ----------RCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC 3000
Score = 182 bits (461), Expect = 4e-45
Identities = 103/295 (34%), Positives = 139/295 (47%), Gaps = 23/295 (7%)
Query: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPA 188
C+GD + EQC + F C +G C+ ++ CDG DC D SDE+ C +
Sbjct: 1013 CEGD-PTNEPPTEQCGLFS-----FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTL--N 1064
Query: 189 PPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMCDSGLCINA 246
C+ F C +G CI + CD +DC D SDE +C +H P C ++ CD+ CI+
Sbjct: 1065 NTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISK 1124
Query: 247 GWRCDGDADCDDQSDERNC-TTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCE 305
W CD D DC D SDE+NC +T C QF C + RC+ LS+ CDG+ DC D SDE C
Sbjct: 1125 NWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC- 1183
Query: 306 NTGSPQCALDQFLCWNG-RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGG 364
C QF C +G +CIG C+GV DC DNSDE+ C P C+ +
Sbjct: 1184 ---VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEA---GC-PTRPPGMCHSDEFQ 1236
Query: 365 CAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCW 419
C + + +C H D H C + C N + W
Sbjct: 1237 CQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYF---HCDNGNCIHRAW 1288
Score = 180 bits (456), Expect = 1e-44
Identities = 118/364 (32%), Positives = 176/364 (48%), Gaps = 28/364 (7%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSH----ACAQSLDKFLLFARRMDIRRI 755
N C + G C C + +Y C C GF +S A+ LL + IR+
Sbjct: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
Query: 756 SFDTEDLSDDVIPLADVRSAVALDWDSRD---DHVYWTDVSTDT----ISRA---KWDGT 805
+ +E S+ + + AV DWD +D VY+T + I RA ++
Sbjct: 4068 NLSSERFSE-YLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESG 4126
Query: 806 GQEVVVDTSLE-----SPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 860
+V + L+ P G+A+DWV +YW+D RIEVA DG R LI +LD+
Sbjct: 4127 RNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQ 4186
Query: 861 PRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY-GSQRLYW 919
P I V P G M+WTDWG PKIE A M+ R +++ +L WP GL+IDY + R+YW
Sbjct: 4187 PAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYW 4246
Query: 920 ADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRL-TGLD 978
+D IE DG+ R+V I + +P+ L ++ +++YW + + ++ G
Sbjct: 4247 SDFKEDVIETIKYDGTDRRV-IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKK 4305
Query: 979 RETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLS 1038
+TL N L + +FH+ R S P + CSHLCL P G+SC CP G + +
Sbjct: 4306 EKTLVVN-PWLTQVRIFHQLRYNKSVPNLCKQ-ICSHLCLL--RPGGYSCACPQGSSFIE 4361
Query: 1039 DGKT 1042
T
Sbjct: 4362 GSTT 4365
Score = 179 bits (454), Expect = 2e-44
Identities = 116/357 (32%), Positives = 173/357 (48%), Gaps = 22/357 (6%)
Query: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGD--GKTCDPSPET-YLLFS 1359
DR L N+C + G C C + C C G D GK C + LL
Sbjct: 4001 DRTSCLDINEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLP 4059
Query: 1360 SRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVD---GKVYYT----DVFLDVIRRA 1412
IR+ +L +S+ ++ E + D+D D VYYT I+RA
Sbjct: 4060 DNVRIRKYNL-SSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRA 4118
Query: 1413 -----DLNGSNMETVIGRGLKTT---DGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKV 1464
+ +N+ + LK DG+AVDWV R++YW+D IE ++LDG RK
Sbjct: 4119 YIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKW 4178
Query: 1465 LINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
LI+ LD+P AIAV P+ G +FWTDWG KIE A ++G +R +L+ DLGWP GL++DY
Sbjct: 4179 LISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 4238
Query: 1525 -DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVD 1583
+ RIYW D D IE+ +G R+V+ +P++L + +YW + + + +
Sbjct: 4239 LNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQN 4298
Query: 1584 KYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACP 1640
K+ KE L V + + + Q + + + C+HLC R + CACP
Sbjct: 4299 KFGQGKKEKTLV-VNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACP 4354
Score = 170 bits (431), Expect = 1e-41
Identities = 112/366 (30%), Positives = 176/366 (48%), Gaps = 31/366 (8%)
Query: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSD--GKTCSP-GMNSFLIFARRIDIRMVSLDIP 1067
G C C + + C C G +SD GK C+ G + L+ + IR +L
Sbjct: 4015 GTCPQHCRNTKG--SYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSE 4072
Query: 1068 YFADVVVPINITMKNTIAIGVDPQE---GKVYWS----DSTLHRISRANLDGS------- 1113
F++ + + DP++ VY++ S I RA +
Sbjct: 4073 RFSEYLQDEEYIQ--AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNL 4130
Query: 1114 -QHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAI 1172
Q D+ + DG+AVD +GR +YW+D RIEV LDG RK L+ +LD P AI
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAI 4190
Query: 1173 VLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASS-QLLWADAH 1231
+ ++G M+WTDWG+ K+E + M+G DR +L+ +LGWP GL++D ++ ++ W+D
Sbjct: 4191 AVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFK 4250
Query: 1232 TERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK-GTGSNVILVR 1290
+ IE +G +R + +PY L + + +YW + + + +K G G +
Sbjct: 4251 EDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
Query: 1291 SNLPGLMDMQAVDRAQPLGFNKCGSR--NGGCSHLCLPRPSGFSCACPTGIQ-LKGDGKT 1347
N P L ++ + L +NK CSHLCL RP G+SCACP G ++G
Sbjct: 4311 VN-PWLTQVRIFHQ---LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 4366
Query: 1348 CDPSPE 1353
CD + E
Sbjct: 4367 CDAAIE 4372
Score = 111 bits (278), Expect = 6e-24
Identities = 72/223 (32%), Positives = 101/223 (45%), Gaps = 39/223 (17%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR 86
C + F+C G CIP + CD DNDC D SDE C PTC F C +G+CI +
Sbjct: 183 CLHNEFSC-----GNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQ 237
Query: 87 SWVCDGDNDCEDDSDEQDCPP-----RECEEDEFPC-QNGYCIRSLWHCDGDNDCGDNSD 140
+WVCDG++DC+D+ DE C +C E+ C ++G CI CDG DC D
Sbjct: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
Query: 141 EQ-------CDMRKCS--DKEFRCSD----GSCIAEHWY---------CDGDTDCKD-GS 177
E C M CS + +++C + G+C Y C DC+ G
Sbjct: 298 ENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGI 357
Query: 178 DEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWS 220
++ C S C+ EE G + +C +D G+ S
Sbjct: 358 CDQKCESRPGRHLCHCEE-----GYILERGQYCKANDSFGEAS 395
Score = 76.3 bits (186), Expect = 3e-13
Identities = 61/201 (30%), Positives = 85/201 (42%), Gaps = 27/201 (13%)
Query: 230 PCRSGEFMCDSGLCI----NAGWRCDGDADCDD-QSDERNCTTSMCTAEQFRC-HSGRCV 283
PC + C S LC+ G+ C+ D Q MC++ QF C ++ +C+
Sbjct: 3468 PCGTNNGGC-SHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCI 3526
Query: 284 RLSWRCDGEDDCADNSDEENCENTGSPQ--CALDQFLCWNGRCIGQRKLCNGVNDCGDNS 341
+ W+CDG+ DC+D SDE PQ C L QF C +G C + LCN +C D S
Sbjct: 3527 PIWWKCDGQKDCSDGSDELAL----CPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGS 3582
Query: 342 DESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAE 401
DE R +C+ N CA K + + + QC D +D + CA
Sbjct: 3583 DED-----RLLCENHHCDSNEWQCANK-RCIPESWQCDTFNDCEDNSD----EDSSHCAS 3632
Query: 402 EGYCSQG---CTNSEGAFQCW 419
C G C N Q W
Sbjct: 3633 R-TCRPGQFRCANGRCIPQAW 3652
Score = 47.4 bits (111), Expect = 1e-04
Identities = 24/80 (30%), Positives = 33/80 (41%)
Query: 288 RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
+C E + ++ ++C +C F C NGRCI + C+ NDCGD SDE
Sbjct: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESV 2735
Query: 348 NCRPRTGEENCNVNNGGCAQ 367
NG C Q
Sbjct: 2736 CALHTCSPTAFTCANGRCVQ 2755
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 1026 bits (2652), Expect = 0.0
Identities = 533/1218 (43%), Positives = 754/1218 (61%), Gaps = 26/1218 (2%)
Query: 440 PVLLFANRIDIRQVLPH--RSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANL 497
P+LLFANR D+R V + E T++++ LE+A A+DF + V+W+DV+ + I + L
Sbjct: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
Query: 498 N--GSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEK 555
N G+ V+ VV +GL SP GLA DWV KLYWTDS T+RIEVANL+G RKVL WQ+L++
Sbjct: 93 NQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQ 152
Query: 556 PRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWV 615
PRAIAL P G +YWTDWG TPRIE + MDGS R+II D+ ++WPNGLTID +++YW
Sbjct: 153 PRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWA 212
Query: 616 DAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675
DAK I RANLDGS R+ V+ L HPFA+T+ D+LYWTDW T+SI++ NK TG ++
Sbjct: 213 DAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRK 272
Query: 676 IIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTGFR-KIS 732
I + L+ PMDI L +RQP RC ++NGGC+HLCL PS YTCACPTG + + +
Sbjct: 273 EILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN 332
Query: 733 SHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDV 792
C ++ LL ARR D+RRIS DT D +D V+ + D+R A+A+D+D + +VYWTD
Sbjct: 333 GRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDD 392
Query: 793 STDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852
I RA DG+G + +V+T + P G+A+DWV LYWTD GTDRIEV +G+ R +
Sbjct: 393 EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKI 452
Query: 853 LIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 912
L+ E+LD PR I + P+ G MYWTDWG +PKIE A +D R+V+++++L WPNGLA+D
Sbjct: 453 LVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDL 512
Query: 913 GSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSAD 972
+LYW DA IE +DG+KR+ L+ +LPH FG TL G+ IYWTDWQ +SI+
Sbjct: 513 QEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVH 572
Query: 973 RLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPT 1032
++ R+ + + L +LM + + + + PCA NGGCSHLC +P+ + C CP
Sbjct: 573 KVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHAT--RCGCPI 629
Query: 1033 GINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQE 1092
G+ LLSD KTC +FL+F R I +SL+ DV +P+ +K A+ D
Sbjct: 630 GLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNN-NDVAIPLT-GVKEASALDFDVSN 686
Query: 1093 GKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGN 1152
+YW+D +L ISRA ++GS E ++ GL +G+AVD +G+ +YW DTGTNRIEV
Sbjct: 687 NHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVAR 746
Query: 1153 LDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGW 1212
LDG R+VLVW++LD+PR++ L G++YWT+WG ++ R+ MDG++ L+ + +G
Sbjct: 747 LDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGR 805
Query: 1213 PNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQT 1272
N LT+D A +L W D T IE++++ G R + + HP+GLT YIYWTDW
Sbjct: 806 ANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNL 865
Query: 1273 RSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFS 1332
SI RADK +G N L++ +L +MD+ ++ G N C NG C LCL P G
Sbjct: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR 925
Query: 1333 CACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDY 1392
C C + L + C P P T+LLFS + +I R+ D D+ +P+ L NV ++DY
Sbjct: 926 CGCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDY 984
Query: 1393 DSVDGKVYYTDVFLDVIRRADLNGSN--METVIGRGL---KTTDGLAVDWVARNLYWTDT 1447
D +D +Y+ D + I+RA +G+ + T + +G + L++D +R L+WT
Sbjct: 985 DPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043
Query: 1448 GRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDW-GHIAKIERANLDGSER 1506
NTI RL G V++ D+PRAI V +GYL++T+ AKIERA LDG+ER
Sbjct: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103
Query: 1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQ 1565
+VL T L P L +D +++WVDA L RIES DL+G R L +++ P LT
Sbjct: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163
Query: 1566 DRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVS--PQRQTGTNACGVNNGG 1623
+ +YW D Q + I+RV+K +G + + V L I V + + C +NGG
Sbjct: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223
Query: 1624 CTHLCFARASDFV-CACP 1640
C+H+C A+ C+CP
Sbjct: 1224 CSHICIAKGDGTPRCSCP 1241
Score = 870 bits (2248), Expect = 0.0
Identities = 436/936 (46%), Positives = 600/936 (64%), Gaps = 24/936 (2%)
Query: 722 CACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWD 781
C CP + A A L LLFA R D+R + L ++ ++ + A A+D+
Sbjct: 23 CGCP-------APAAASPL---LLFANRRDVRLVDAGGVKLESTIV-VSGLEDAAAVDFQ 71
Query: 782 SRDDHVYWTDVSTDTISRAKWDGTGQEV--VVDTSLESPAGLAIDWVTNKLYWTDAGTDR 839
VYWTDVS + I + + TG V VV + L SP GLA DWV KLYWTD+ T+R
Sbjct: 72 FSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNR 131
Query: 840 IEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIIS 899
IEVAN +G+ R VL W++LD+PR I ++P GYMYWTDWG +P+IERAGMD S R++I+
Sbjct: 132 IEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVD 191
Query: 900 SNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIY 959
S++ WPNGL ID Q+LYWADA + I A LDGS R+ ++ L HPF LTL G+ +Y
Sbjct: 192 SDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLY 251
Query: 960 WTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPV-STPCAMENGGCSHLCL 1018
WTDWQT+SI + ++ TG R+ + L + MDI V + R P T C +NGGCSHLCL
Sbjct: 252 WTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCL 311
Query: 1019 RSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINI 1078
SP+ ++C CPTG+ L +G+TC G L+ ARR D+R +SLD P F D+V+ ++
Sbjct: 312 LSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVD- 370
Query: 1079 TMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKV 1138
+++ IAI DP EG VYW+D + I RA LDGS + ++ T + DG+AVD + R +
Sbjct: 371 DIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNL 430
Query: 1139 YWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMD 1198
YWTDTGT+RIEV L+G+ RK+LV ++LD PRAI L+ MG MYWTDWGEN K+E + +D
Sbjct: 431 YWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLD 490
Query: 1199 GSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP-VQHPYG 1257
G +R VL+N +LGWPNGL +D +L W DA T++IE +++G R TL+ + H +G
Sbjct: 491 GQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFG 550
Query: 1258 LTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRN 1317
TLL +IYWTDWQ RSI R K S +++ LP LM ++AV+ A+ +G N C RN
Sbjct: 551 FTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRN 609
Query: 1318 GGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDV 1377
GGCSHLC P C CP G++L D KTC PE +L+F+SR +I RISL+T+++ DV
Sbjct: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DV 667
Query: 1378 HVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDW 1437
+P+ + +LD+D + +Y+TDV L I RA +NGS++E V+ GL +G+AVDW
Sbjct: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDW 727
Query: 1438 VARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIE 1497
+ +NLYW DTG N IE +RLDG R+VL+ LD PR++A+ P KGY++WT+WG +I
Sbjct: 728 MGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIV 787
Query: 1498 RANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVS 1557
RA +DG+ L++ +G N LT+DY +R+YW D + IES+++ G+ R V+ +
Sbjct: 788 RAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLP 846
Query: 1558 HPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNAC 1617
HPF LTQ +IYWTDW SI+R DK SGRN+ + +++ +MDI+V RQ G N C
Sbjct: 847 HPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDC 906
Query: 1618 GVNNGGCTHLCFARASDFVCACPD----EPDSRPCS 1649
NNG C LC A C C +P SR CS
Sbjct: 907 MHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCS 942
Score = 712 bits (1839), Expect = 0.0
Identities = 387/972 (39%), Positives = 562/972 (57%), Gaps = 31/972 (3%)
Query: 399 CAEE-GYCSQGC--TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQV-- 453
C E+ G CS C + SE + C C TG +L+ + R+CKA G E VLL A R D+R++
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISL 357
Query: 454 -LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLES 512
P ++ L ++++ +AIA+D+ V+W+D + I RA L+GS + +V+T +
Sbjct: 358 DTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEIND 417
Query: 513 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 572
P G+AVDWV LYWTD+GT RIEV L+G RK+L+ ++L++PRAIALHP+ G +YWTD
Sbjct: 418 PDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTD 477
Query: 573 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
WG P+IE +++DG RR++ + L WPNGL +D ++YW DAK IE N+DG+ R
Sbjct: 478 WGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 537
Query: 633 KAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP 692
+ ++ LPH F T+ D +YWTDW +SI +K ++++I ++L M + ++
Sbjct: 538 RTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNV 596
Query: 693 QRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDI 752
+ G N C D NGGC+HLC + C CP G +S + FL+F R I
Sbjct: 597 AK-VVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAI 655
Query: 753 RRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVD 812
RIS +T + +D IPL V+ A ALD+D ++H+YWTDVS TISRA +G+ E VV+
Sbjct: 656 HRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVE 714
Query: 813 TSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGY 872
L+ P G+A+DW+ LYW D GT+RIEVA DG R VL+W +LD PR + ++P GY
Sbjct: 715 FGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGY 774
Query: 873 MYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGL 932
+YWT+WG P+I RA MD + ++ + N L IDY QRLYW D IE + +
Sbjct: 775 IYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNM 833
Query: 933 DGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDI 992
G +R V+I LPHPFGLT Y + IYWTDW SI+ AD+ +G +R +Q +L+ +MDI
Sbjct: 834 LGQER-VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI 892
Query: 993 HVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLI 1052
VFH R C NG C LCL P G C C + L + CSP +FL+
Sbjct: 893 LVFHSSRQDGLNDCMHNNGQCGQLCLAI--PGGHRCGCASHYTLDPSSRNCSP-PTTFLL 949
Query: 1053 FARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDG 1112
F+++ I + D + D+++P++ ++N AI DP + +YW D I RA DG
Sbjct: 950 FSQKSAISRMIPDDQHSPDLILPLH-GLRNVKAIDYDPLDKFIYWVDGR-QNIKRAKDDG 1007
Query: 1113 SQHEDIITTGL---QTTD----GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQN 1165
+Q + T L Q D L++D R ++WT TN I V L G V++ +
Sbjct: 1008 TQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGD 1065
Query: 1166 LDSPRAIVLYHEMGFMYWTDWGEN-AKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQ 1224
D PRAIV+ E G++Y+T+ + AK+ER+ +DG++R VL L P L VD +
Sbjct: 1066 RDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGK 1125
Query: 1225 LLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTG 1283
L W DA +RIE+ DL+GANR TL + + P GLT+L ++YW D Q + I R +K TG
Sbjct: 1126 LFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
Query: 1284 SNVILVRSNLPGLMDMQAVDRA--QPLGFNKCGSRNGGCSHLCLPRPSGF-SCACPTGIQ 1340
++ + L + AV+ + + C NGGCSH+C+ + G C+CP +
Sbjct: 1186 DKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLV 1245
Query: 1341 LKGDGKTCDPSP 1352
L + TC P
Sbjct: 1246 LLQNLLTCGEPP 1257
Score = 436 bits (1122), Expect = e-122
Identities = 255/708 (36%), Positives = 370/708 (52%), Gaps = 63/708 (8%)
Query: 354 GEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSE 413
G C NGGC+ C A +C C G L D TC
Sbjct: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC-------------------- 640
Query: 414 GAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL--PHRSEYTLLLNNLENAI 471
+ PE L+F +R I ++ + ++ + L ++ A
Sbjct: 641 ----------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
Query: 472 ALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSG 531
ALDF ++W+DV+L I RA +NGS+VE VV GL+ P G+AVDW+ LYW D+G
Sbjct: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 738
Query: 532 TSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRI 591
T+RIEVA LDG R+VL+W++L+ PR++AL P +G IYWT+WG PRI + MDG+
Sbjct: 739 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT 798
Query: 592 IADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFED 651
+ D + N LTIDYA +R+YW D ++IE +N+ G R VI+ LPHPF +T + D
Sbjct: 799 LVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSD 856
Query: 652 SLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTH 711
+YWTDW+ SI A+K +G+N+ +I+ L F MDI H RQ G N C NNG C
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQD-GLNDCMHNNGQCGQ 915
Query: 712 LCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLAD 771
LCL + C C + + S FLLF+++ I R+ D + D ++PL
Sbjct: 916 LCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG 975
Query: 772 VRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSL-----ESPAGLAIDWV 826
+R+ A+D+D D +YW D I RAK DGT V+ S P L+ID
Sbjct: 976 LRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIY 1034
Query: 827 TNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW-GASPKIE 885
+ L+WT T+ I V G V++ + D+PR IVV GY+Y+T+ + KIE
Sbjct: 1035 SRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIE 1094
Query: 886 RAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 945
RA +D + R+V+ ++ L P L +D +L+W DA +K IE L G+ R L + +
Sbjct: 1095 RAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANI 1154
Query: 946 PHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR--RRPPVS 1003
P GLT+ G+ +YW D Q + I+ ++ TG R +Q + +L IH +
Sbjct: 1155 VQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSA 1214
Query: 1004 TPCAMENGGCSHLCLRSPNPSGFSCTCPTGI----NLLSDGK--TCSP 1045
PCA +NGGCSH+C+ + + C+CP + NLL+ G+ TCSP
Sbjct: 1215 HPCARDNGGCSHICIAKGDGTP-RCSCPVHLVLLQNLLTCGEPPTCSP 1261
Score = 115 bits (289), Expect = 3e-25
Identities = 69/195 (35%), Positives = 94/195 (48%), Gaps = 27/195 (13%)
Query: 128 HCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP---- 183
H G + + S E+ C+ CS CIA+ DG+ +CP
Sbjct: 1197 HLTGIHAVEEVSLEEFSAHPCARDNGGCSH-ICIAKG----------DGTPRCSCPVHLV 1245
Query: 184 ------SAVPAPPCNLEEFQCAYGR--CILDIYHCDGDDDCGDWSDESDCSSHQPCRSGE 235
+ P C+ ++F CA G CI + CDG +C D SDE C C + +
Sbjct: 1246 LLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQ 1302
Query: 236 FMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDC 295
F C G C++ RCDG+ADC D+SDE +C ++C QFRC SG+CV + +CD DC
Sbjct: 1303 FPCARGQCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
Query: 296 ADNSDEENCENTGSP 310
D SDE CE T P
Sbjct: 1362 IDGSDELMCEITKPP 1376
Score = 111 bits (278), Expect = 6e-24
Identities = 55/122 (45%), Positives = 66/122 (54%), Gaps = 6/122 (4%)
Query: 69 PTCSPLDFHCDNGK--CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSL 126
PTCSP F C G+ CI +W CDG +C+D SDE+ CP C +FPC G C+
Sbjct: 1257 PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDLR 1314
Query: 127 WHCDGDNDCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
CDG+ DC D SDE CD C +FRC+ G C+ CD DC DGSDE C
Sbjct: 1315 LRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEIT 1373
Query: 186 VP 187
P
Sbjct: 1374 KP 1375
Score = 111 bits (277), Expect = 8e-24
Identities = 54/121 (44%), Positives = 69/121 (57%), Gaps = 8/121 (6%)
Query: 225 CSSHQPCRSGEFMCDSGL--CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282
C C +F C +G CI WRCDG +CDDQSDE C +C+A QF C G+C
Sbjct: 1253 CGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQC 1310
Query: 283 VRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSD 342
V L RCDGE DC D SDE +C+ C +QF C +G+C+ ++ C+ DC D SD
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAI----CLPNQFRCASGQCVLIKQQCDSFPDCIDGSD 1366
Query: 343 E 343
E
Sbjct: 1367 E 1367
Score = 108 bits (271), Expect = 4e-23
Identities = 53/122 (43%), Positives = 66/122 (54%), Gaps = 7/122 (5%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR 86
C F CA GE CIP W+CDG +C D SDE+GC P CS F C G+C+
Sbjct: 1259 CSPDQFACAT---GEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDL 1313
Query: 87 SWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDM 145
CDG+ DC+D SDE DC C ++F C +G C+ CD DC D SDE C++
Sbjct: 1314 RLRCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
Query: 146 RK 147
K
Sbjct: 1373 TK 1374
Score = 103 bits (256), Expect = 2e-21
Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 10/134 (7%)
Query: 148 CSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCIL 205
CS +F C+ G CI W CDG +C D SDEE CP C+ +F CA G+C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARGQCVD 1312
Query: 206 DIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
CDG+ DC D SDE+DC + C +F C SG C+ +CD DC D SDE C
Sbjct: 1313 LRLRCDGEADCQDRSDEADCDAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 266 TTSMCTAEQFRCHS 279
+ ++ HS
Sbjct: 1371 EITKPPSDDSPAHS 1384
Score = 73.9 bits (180), Expect = 1e-12
Identities = 34/77 (44%), Positives = 45/77 (58%), Gaps = 7/77 (9%)
Query: 270 CTAEQFRCHSGR--CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ 327
C+ +QF C +G C+ +WRCDG +C D SDEE C P C+ QF C G+C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-----PVCSAAQFPCARGQCVDL 1313
Query: 328 RKLCNGVNDCGDNSDES 344
R C+G DC D SDE+
Sbjct: 1314 RLRCDGEADCQDRSDEA 1330
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 603 bits (1554), Expect = e-172
Identities = 315/777 (40%), Positives = 426/777 (54%), Gaps = 50/777 (6%)
Query: 5 WGALLLGALLCAH----GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60
W LL AL A + + C S F C CI W+CDGD DC D
Sbjct: 7 WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDG 61
Query: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPC- 117
SDE C+ TC+ DF C+NG+C+ W CDGD DCED SDE + C R C E C
Sbjct: 62 SDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
Query: 118 -QNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175
+ CI W CDG+NDC DE+ C CS EF CS G CI+ ++ C+G DC D
Sbjct: 122 AHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD 181
Query: 176 GSDEENCPSAVPAPP-CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDES--DCSS----H 228
GSDE +C APP C EFQC+ CI + CD D DC D SDES C H
Sbjct: 182 GSDELDC-----APPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
Query: 229 QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWR 288
C + E C SG CI+ WRCDGD DC D SDE NC + C +QF C G C+ S +
Sbjct: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 289 CDGEDDCADNSDEENCENTGSPQC-ALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
C+G DC D SDE NC+N QC +F C +G CI K+CN DC D SDE P +
Sbjct: 297 CNGIRDCVDGSDEVNCKNVN--QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE-PLK 353
Query: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
C C VNNGGC+ C+ + +C C G+ L D TC D++EC G CSQ
Sbjct: 354 ECHIN----ECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQ 408
Query: 408 GCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL 467
C N +G ++C C GY++ CKA+G EP L+F NR DIR++ R EY L+ L
Sbjct: 409 ICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
Query: 468 ENAIALDFHHRRELVFWSDVTLDRILRANLN---GSNVEEVVSTGLESPGGLAVDWVHDK 524
N +ALD + +FW+D++ I A+++ G +V+ + + +P +AVDWV+
Sbjct: 469 RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKT 526
Query: 525 LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584
+YWTD+ + I VA LDG RK L +L +P +IA+ P+ G +YW+DWG +IE + M
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
Query: 585 DGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPH 642
+G RR + + WPNG+T+D R+YW+D+K H++ +L+G R+ V+ + L H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 643 PFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC 702
P A+T+FED +YW D +++ ANKFTG + N L+ DI H QP+GKN C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
Query: 703 GDN--NGGCTHLCLPSGQ------NYTCACPTGFRKISSHACAQSLDKFLLFARRMD 751
++ NGGC +LCLP+ Q YTC+CP+G+ + QS + ++ D
Sbjct: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKD 763
Score = 239 bits (609), Expect = 2e-62
Identities = 125/362 (34%), Positives = 203/362 (56%), Gaps = 20/362 (5%)
Query: 699 KNRCGD-----NNGGCTHLCLPSGQNYTCACPTGFRK-ISSHAC-AQSLDKFLLFARRMD 751
+ CGD N G C+ +C+ Y C C G++ +++ C A + L+F R D
Sbjct: 391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD 450
Query: 752 IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG-TGQEVV 810
IR+I + ++ V L R+ VALD D ++W D+S I A D G+ V
Sbjct: 451 IRKIGLERKEYIQLVEQL---RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
Query: 811 VDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMG 870
+ ++ +PA +A+DWV +YWTDA + I VA DG+ R L +L P I V+P+
Sbjct: 508 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
Query: 871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFA 930
G++YW+DWG KIE+AGM+ R+ ++++++ WPNG+ +D RLYW D+ + +
Sbjct: 568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 931 GLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLEN 988
L+G R++++ S L HP LT++ +R+YW D + +++ A++ TG + TL NL +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 989 LMDIHVFHRR-RPPVSTPCA--MENGGCSHLCLRSP----NPSGFSCTCPTGINLLSDGK 1041
DI V+H +P C MENGGC +LCL +P + ++C+CP+G N+ +G+
Sbjct: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
Query: 1042 TC 1043
C
Sbjct: 748 DC 749
Score = 234 bits (597), Expect = 6e-61
Identities = 148/499 (29%), Positives = 248/499 (49%), Gaps = 65/499 (13%)
Query: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDP-SPETYLLF 1358
+ +DR ++C G CS +C+ G+ C C G Q+ C E L+F
Sbjct: 387 ELIDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIF 445
Query: 1359 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418
++R IR+I L+ ++ + V +L N ++LD D K+++ D+ I A ++
Sbjct: 446 TNRRDIRKIGLERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK- 501
Query: 1419 METVIGRGLKTTDG------LAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472
+GR +K D +AVDWV + +YWTD TI + LDG+ RK L N+ L E
Sbjct: 502 ----VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLRE 557
Query: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
P +IAV P G+++W+DWG AKIE+A ++G +R+ L+ D+ WPNG+TLD R+YW+
Sbjct: 558 PASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWL 617
Query: 1533 DAHLDRIESADLNGKLRQVL---VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRN 1589
D+ L + S DLNG+ R+++ + ++HP ALT + +YW D + +++ +K++G
Sbjct: 618 DSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSE 677
Query: 1590 KETVLANVEGLMDIIVVSPQRQ-TGTNAC--GVNNGGCTHLCFA------RASDFVCACP 1640
T++ N+ DIIV Q +G N C + NGGC +LC + + C+CP
Sbjct: 678 LATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Query: 1641 D----EPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGR 1696
E + R C +T T YS T T T+ E+
Sbjct: 738 SGYNVEENGRDCQ-----------------------STATTVTYSETKDTNTT--EISAT 772
Query: 1697 CSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTD 1756
+ + ++ + P +G ++AI LL LL++ + +++R+ + K
Sbjct: 773 SGLVPGGINVTTAVSEV--SVPPKGTSAAWAILPLL--LLVMAAVGGYLMWRNWQHK--- 825
Query: 1757 PGMGNLTYSNPSYRTSTQE 1775
M ++ + NP Y +T+E
Sbjct: 826 -NMKSMNFDNPVYLKTTEE 843
Score = 216 bits (549), Expect = 2e-55
Identities = 125/403 (31%), Positives = 200/403 (49%), Gaps = 61/403 (15%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC-------SPGMNS--------- 1049
C + NGGCSH+C G+ C C G L+ D KTC +PG+ S
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
Query: 1050 -------------------------FLIFARRIDIRMVSLDIPYFADVVVPINITMKNTI 1084
LIF R DIR + L+ + +V + +NT+
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL----RNTV 472
Query: 1085 AIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDI-ITTGLQTTDGLAVDAIGRKVYWTDT 1143
A+ D K++W+D + I A++D + + + +AVD + + +YWTD
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 1144 GTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRA 1203
+ I V LDG+ RK L +L P +I + GF+YW+DWGE AK+E++GM+G DR
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 1204 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQ---HPYGLTL 1260
L+ ++ WPNG+T+D S+L W D+ + + DLNG +R ++ ++ HP LT+
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
Query: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKC--GSRN 1317
+ +YW D + +++ A+K TGS + + +NL D+ + QP G N C N
Sbjct: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMEN 712
Query: 1318 GGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
GGC +LCLP P ++C+CP+G ++ +G+ C + T
Sbjct: 713 GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Score = 35.0 bits (79), Expect = 0.70
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCAC 1639
P ++ N C VNNGGC+H+C + C C
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 602 bits (1553), Expect = e-172
Identities = 312/754 (41%), Positives = 419/754 (55%), Gaps = 50/754 (6%)
Query: 5 WGALLLGALLCAH----GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60
W LL AL A + + C S F C CI W+CDGD DC D
Sbjct: 7 WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDG 61
Query: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPC- 117
SDE C+ TC+ DF C+NG+C+ W CDGD DCED SDE + C R C E C
Sbjct: 62 SDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
Query: 118 -QNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175
+ CI W CDG+NDC DE+ C CS EF CS G CI+ ++ C+G DC D
Sbjct: 122 AHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD 181
Query: 176 GSDEENCPSAVPAPP-CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDES--DCSS----H 228
GSDE +C APP C EFQC+ CI + CD D DC D SDES C H
Sbjct: 182 GSDELDC-----APPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
Query: 229 QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWR 288
C + E C SG CI+ WRCDGD DC D SDE NC + C +QF C G C+ S +
Sbjct: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 289 CDGEDDCADNSDEENCENTGSPQC-ALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
C+G DC D SDE NC+N QC +F C +G CI K+CN DC D SDE P +
Sbjct: 297 CNGIRDCVDGSDEVNCKNVN--QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE-PLK 353
Query: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
C C VNNGGC+ C+ + +C C G+ L D TC D++EC G CSQ
Sbjct: 354 ECHIN----ECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQ 408
Query: 408 GCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL 467
C N +G ++C C GY++ CKA+G EP L+F NR DIR++ R EY L+ L
Sbjct: 409 ICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
Query: 468 ENAIALDFHHRRELVFWSDVTLDRILRANLN---GSNVEEVVSTGLESPGGLAVDWVHDK 524
N +ALD + +FW+D++ I A+++ G +V+ + + +P +AVDWV+
Sbjct: 469 RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKT 526
Query: 525 LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584
+YWTD+ + I VA LDG RK L +L +P +IA+ P+ G +YW+DWG +IE + M
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
Query: 585 DGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPH 642
+G RR + + WPNG+T+D R+YW+D+K H++ +L+G R+ V+ + L H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 643 PFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC 702
P A+T+FED +YW D +++ ANKFTG + N L+ DI H QP+GKN C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
Query: 703 GDN--NGGCTHLCLPSGQ------NYTCACPTGF 728
++ NGGC +LCLP+ Q YTC+CP+G+
Sbjct: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
Score = 239 bits (609), Expect = 2e-62
Identities = 125/362 (34%), Positives = 203/362 (56%), Gaps = 20/362 (5%)
Query: 699 KNRCGD-----NNGGCTHLCLPSGQNYTCACPTGFRK-ISSHAC-AQSLDKFLLFARRMD 751
+ CGD N G C+ +C+ Y C C G++ +++ C A + L+F R D
Sbjct: 391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD 450
Query: 752 IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG-TGQEVV 810
IR+I + ++ V L R+ VALD D ++W D+S I A D G+ V
Sbjct: 451 IRKIGLERKEYIQLVEQL---RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
Query: 811 VDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMG 870
+ ++ +PA +A+DWV +YWTDA + I VA DG+ R L +L P I V+P+
Sbjct: 508 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
Query: 871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFA 930
G++YW+DWG KIE+AGM+ R+ ++++++ WPNG+ +D RLYW D+ + +
Sbjct: 568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 931 GLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLEN 988
L+G R++++ S L HP LT++ +R+YW D + +++ A++ TG + TL NL +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 989 LMDIHVFHRR-RPPVSTPCA--MENGGCSHLCLRSP----NPSGFSCTCPTGINLLSDGK 1041
DI V+H +P C MENGGC +LCL +P + ++C+CP+G N+ +G+
Sbjct: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
Query: 1042 TC 1043
C
Sbjct: 748 DC 749
Score = 223 bits (568), Expect = 1e-57
Identities = 144/489 (29%), Positives = 243/489 (49%), Gaps = 73/489 (14%)
Query: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDP-SPETYLLF 1358
+ +DR ++C G CS +C+ G+ C C G Q+ C E L+F
Sbjct: 387 ELIDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIF 445
Query: 1359 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418
++R IR+I L+ ++ + V +L N ++LD D K+++ D+ I A ++
Sbjct: 446 TNRRDIRKIGLERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK- 501
Query: 1419 METVIGRGLKTTDG------LAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472
+GR +K D +AVDWV + +YWTD TI + LDG+ RK L N+ L E
Sbjct: 502 ----VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLRE 557
Query: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
P +IAV P G+++W+DWG AKIE+A ++G +R+ L+ D+ WPNG+TLD R+YW+
Sbjct: 558 PASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWL 617
Query: 1533 DAHLDRIESADLNGKLRQVL---VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRN 1589
D+ L + S DLNG+ R+++ + ++HP ALT + +YW D + +++ +K++G
Sbjct: 618 DSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSE 677
Query: 1590 KETVLANVEGLMDIIVVSPQRQ-TGTNAC--GVNNGGCTHLCFARASDFVCACPDEPDSR 1646
T++ N+ DIIV Q +G N C + NGGC +LC
Sbjct: 678 LATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL----------------- 720
Query: 1647 PCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGL 1706
PAP+ S K Y+ + + ++EE C R+ +
Sbjct: 721 ----------PAPQINDHSPK------------YTCSCPSGYNVEENGRDCQ----RINV 754
Query: 1707 CARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSN 1766
++ + P +G ++AI LL LL++ + +++R+ + K M ++ + N
Sbjct: 755 TTAVSEV--SVPPKGTSAAWAILPLL--LLVMAAVGGYLMWRNWQHK----NMKSMNFDN 806
Query: 1767 PSYRTSTQE 1775
P Y +T+E
Sbjct: 807 PVYLKTTEE 815
Score = 214 bits (546), Expect = 5e-55
Identities = 124/397 (31%), Positives = 198/397 (49%), Gaps = 61/397 (15%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC-------SPGMNS--------- 1049
C + NGGCSH+C G+ C C G L+ D KTC +PG+ S
Sbjct: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
Query: 1050 -------------------------FLIFARRIDIRMVSLDIPYFADVVVPINITMKNTI 1084
LIF R DIR + L+ + +V + +NT+
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL----RNTV 472
Query: 1085 AIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDI-ITTGLQTTDGLAVDAIGRKVYWTDT 1143
A+ D K++W+D + I A++D + + + +AVD + + +YWTD
Sbjct: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 1144 GTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRA 1203
+ I V LDG+ RK L +L P +I + GF+YW+DWGE AK+E++GM+G DR
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 1204 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQ---HPYGLTL 1260
L+ ++ WPNG+T+D S+L W D+ + + DLNG +R ++ ++ HP LT+
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
Query: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKC--GSRN 1317
+ +YW D + +++ A+K TGS + + +NL D+ + QP G N C N
Sbjct: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMEN 712
Query: 1318 GGCSHLCLPRPS------GFSCACPTGIQLKGDGKTC 1348
GGC +LCLP P ++C+CP+G ++ +G+ C
Sbjct: 713 GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 35.0 bits (79), Expect = 0.70
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCAC 1639
P ++ N C VNNGGC+H+C + C C
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
Score = 33.9 bits (76), Expect = 1.6
Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 329 KLCNGVNDCGDNSDESPQQNCRPRTGEENC--NVNNGGCAQKCQMV------RGAVQCTC 380
+L VN+ D D +G+ C ++ NGGC C C+C
Sbjct: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
Query: 381 HTGYRLTEDGHTCQDVN 397
+GY + E+G CQ +N
Sbjct: 737 PSGYNVEENGRDCQRIN 753
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 557 bits (1436), Expect = e-158
Identities = 278/686 (40%), Positives = 383/686 (55%), Gaps = 40/686 (5%)
Query: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPCQN--GYCIRSL 126
C +F C +GKCI WVCDG +C+D SDE + C C+ +F C CI
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 127 WHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
W CDG DC + SDEQ C + CS EFRC DG CI+ + CD D DC DGSDE +CP
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
Query: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE--SDC-------SSHQPCRSGEF 236
C FQC CI ++ CD D DC D SDE C PC + EF
Sbjct: 147 T----CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
Query: 237 MCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCA 296
C SG CI++ WRCDG DC D+SDE NC + C ++F+C G C+ S +CD E DC
Sbjct: 203 HCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCK 262
Query: 297 DNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEE 356
D SDE C N + ++F C +G CI K+CN DC D SDE P + C G
Sbjct: 263 DMSDEVGCVNVTLCE-GPNKFKCHSGECITLDKVCNMARDCRDWSDE-PIKEC----GTN 316
Query: 357 NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAF 416
C NNGGC+ C ++ +C C G++L C+D++EC + CSQ C N EG +
Sbjct: 317 ECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLEGGY 375
Query: 417 QCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFH 476
+C CE G++L P ++CKA+G L F NR ++R++ RSEYT L+ NL N +ALD
Sbjct: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTE 435
Query: 477 HRRELVFWSDVTLDRILRANLNG----SNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532
++WSD++ I L+ S+ + V+S +++P GLAVDW+H +YWTDS
Sbjct: 436 VASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVL 495
Query: 533 SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592
+ VA+ G RK L +N KPRAI + P+ G +YWTDWG +I+ ++G +
Sbjct: 496 GTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSL 555
Query: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFE 650
++ WPNG+T+D R+YWVD+K H I +++G +RK ++ + L HPF++ VFE
Sbjct: 556 VTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFE 615
Query: 651 DSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGD---NNG 707
D ++WTD ++I SAN+ TG + ++ L P D+ H QP G N C +NG
Sbjct: 616 DKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNG 675
Query: 708 GCTHLCLPSGQ------NYTCACPTG 727
GC +LCLP+ Q +TCACP G
Sbjct: 676 GCQYLCLPAPQINPHSPKFTCACPDG 701
Score = 245 bits (626), Expect = 3e-64
Identities = 131/402 (32%), Positives = 211/402 (52%), Gaps = 60/402 (14%)
Query: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDK--------------- 742
G N C DNNGGC+H+C Y C CP GF+ ++ C + +D+
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC-EDIDECQDPDTCSQLCVNLE 372
Query: 743 ---------------------------FLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
+L F R ++R+++ D + + +IP ++R+
Sbjct: 373 GGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS-LIP--NLRNV 429
Query: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDG----TGQEVVVDTSLESPAGLAIDWVTNKLY 831
VALD + + +YW+D+S I + D + + V+ +++P GLA+DW+ + +Y
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489
Query: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
WTD+ + VA+T G R L EN +PR IVV+P+ G+MYWTDWG KI++ G++
Sbjct: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549
Query: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
+++ N+ WPNG+ +D S RLYW D+ + +I ++G RK ++ + L HPF
Sbjct: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609
Query: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVST----P 1005
L ++ ++++WTD ++I SA+RLTG D L ENL + D+ +FH P
Sbjct: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCER 669
Query: 1006 CAMENGGCSHLCLRSP--NPSG--FSCTCPTGINLLSDGKTC 1043
+ NGGC +LCL +P NP F+C CP G+ L D ++C
Sbjct: 670 TTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 232 bits (591), Expect = 3e-60
Identities = 157/540 (29%), Positives = 255/540 (47%), Gaps = 92/540 (17%)
Query: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKG-----------DGKTC--------- 1348
G N+C NGGCSH+C G+ C CP G QL D TC
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG 373
Query: 1349 ------------DPSPET--------YLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVI 1388
DP + YL F++R +R+++LD S++T + +P L NV+
Sbjct: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL---IPNLRNVV 430
Query: 1389 SLDYDSVDGKVYYTDVFLDVIRRADLNG----SNMETVIGRGLKTTDGLAVDWVARNLYW 1444
+LD + ++Y++D+ +I L+ S+ +TVI R ++ DGLAVDW+ N+YW
Sbjct: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYW 490
Query: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
TD+ T+ + G RK L + +PRAI V P G+++WTDWG AKI++ L+G
Sbjct: 491 TDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
Query: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV---SHVSHPFA 1561
+ L+ ++ WPNG+TLD + R+YWVD+ L I S D+NG R+ ++ ++HPF+
Sbjct: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFS 610
Query: 1562 LTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNAC--- 1617
L + ++WTD ++I ++ +G + + N+ D+++ Q G N C
Sbjct: 611 LAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERT 670
Query: 1618 GVNNGGCTHLCF------ARASDFVCACPD----EPDSRPCSLVPGLVPPAPRATGMSEK 1667
++NGGC +LC + F CACPD D R C + A A E
Sbjct: 671 TLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC------LTEAEAAVATQET 724
Query: 1668 SPVLPNTPPTTLYSSTTRTR------------TSLEEVEGRCSERDARLGLCARSNDAVP 1715
S V T + + T TR L VE A + R N+ P
Sbjct: 725 STVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKP 784
Query: 1716 AAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQE 1775
++ L I I +LL+ + + +L+++ + K + ++ + NP Y+ +T++
Sbjct: 785 SSV-RALSIVLPI-----VLLVFLCLGVFLLWKNWRLK----NINSINFDNPVYQKTTED 834
Score = 229 bits (585), Expect = 1e-59
Identities = 133/396 (33%), Positives = 202/396 (51%), Gaps = 28/396 (7%)
Query: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSP-GMNSFLIFARRIDIRMVSLDIPYFAD 1071
CS LC+ G+ C C G L K C G ++L F R ++R ++LD +
Sbjct: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS 421
Query: 1072 VVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDG----SQHEDIITTGLQTTD 1127
++ ++N +A+ + ++YWSD + I LD S ++ +I+ +Q D
Sbjct: 422 LIP----NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
Query: 1128 GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG 1187
GLAVD I +YWTD+ + V + G RK L +N PRAIV+ GFMYWTDWG
Sbjct: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
Query: 1188 ENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHT 1247
AK+++ G++G D L+ N+ WPNG+T+D S +L W D+ I + D+NG NR T
Sbjct: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
Query: 1248 LVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-D 1303
++ + HP+ L + + ++WTD +I A++ TGS+V L+ NL DM +
Sbjct: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
Query: 1304 RAQPLGFNKCGS---RNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
QP G N C NGGC +LCLP P F+CACP G+ L D ++C E
Sbjct: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
Query: 1355 YLLFSSRGSIRRISLDT---SDHTDVHVPVPELNNV 1387
+ ++R T + HT PVP+ + +
Sbjct: 718 AVATQETSTVRLKVSSTAVRTQHTTTR-PVPDTSRL 752
Score = 42.0 bits (97), Expect = 0.006
Identities = 16/34 (47%), Positives = 21/34 (61%)
Query: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCACPD 1641
P ++ GTN C NNGGC+H+C + C CPD
Sbjct: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 550 bits (1417), Expect = e-156
Identities = 279/691 (40%), Positives = 380/691 (54%), Gaps = 51/691 (7%)
Query: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC--- 163
Query: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS---GL 242
A C EFQC C+ ++ CDGDDDCGD SDE C+ C EF C G
Sbjct: 164 --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD-PACGPREFRCGGDGGGA 220
Query: 243 CINAGWRCDGDADCDDQSDER------------NCTTSMCTAEQFRCHSGRCVRLSWRCD 290
CI W CD DC+D+SDE + + TA QF C SG CV L WRCD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 291 GEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
G+ DC D SDE +C C D+F C +G C+ K CN DC D SDE+ C
Sbjct: 281 GDRDCKDKSDEADCP---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCL 334
Query: 351 PRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410
G C NNGGC+ C ++ +CTC G++L D TC D++EC + CSQ C
Sbjct: 335 Q--GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICV 391
Query: 411 NSEGAFQCWCETGYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469
N +G F+C C GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 470 AIALDFHHRRELVFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKL 525
+ALD ++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 526 YWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMD 585
YWTDSG I VA +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 586 GSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHP 643
G R+ + ++ WPNG+T+D +R+YWVD+K H + + G +RK +IS L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 644 FAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG 703
F I VFED ++WTD ++I SAN+ G I+ L+ P DI H +QP + C
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
Query: 704 ---DNNGGCTHLCLPSGQ------NYTCACP 725
NGGC +LCLP+ Q YTCACP
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Score = 263 bits (673), Expect = 9e-70
Identities = 146/403 (36%), Positives = 204/403 (50%), Gaps = 61/403 (15%)
Query: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736
G N C NNGGC+H+C + C CP GF+ + C
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 737 ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
A L+F R ++RRI + S +IP+ +++
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR-LIPM--LKNV 452
Query: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831
VALD + + +YW D+S I A D QEV++D L SP GLA+DWV +Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
WTD+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
Query: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPF
Sbjct: 573 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
Query: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
G+ ++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 633 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 691
Query: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043
NGGC +LCL +P S ++C CP + L D K C
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 258 bits (659), Expect = 4e-68
Identities = 168/545 (30%), Positives = 271/545 (49%), Gaps = 86/545 (15%)
Query: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352
G N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 394
Query: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
E Y L+F++R +RRI L +++ + +P L N
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 451
Query: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442
V++LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502
YWTD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559
G +R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618
F + + ++WTD + ++I ++ +G + N+ DI++ +Q +AC
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
Query: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMS 1665
++ NGGC +LC + + + CACPD PD + C P A+ M+
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT 751
Query: 1666 EKSPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVP 1715
P P TT++ ST T T + V R A SN +
Sbjct: 752 RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQH 811
Query: 1716 AAPGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYR 1770
A + S ++ I++ +VVIA L +++R+ K K T ++ + NP YR
Sbjct: 812 YANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYR 867
Query: 1771 TSTQE 1775
+T+E
Sbjct: 868 KTTEE 872
Score = 234 bits (596), Expect = 8e-61
Identities = 131/408 (32%), Positives = 207/408 (50%), Gaps = 66/408 (16%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC---------------------- 1043
C NGGCSH+C + GF CTCP G LL D KTC
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 396
Query: 1044 --------------------SPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNT 1083
+ G + LIF R ++R + L ++ ++ +KN
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNV 452
Query: 1084 IAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQTTDGLAVDAIGRKVY 1139
+A+ V+ ++YW D + +I A +D + + E +I L + +GLAVD + + +Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
WTD+G I V +DG R+ L +NL PRAI + GFMYW+DWG+ AK+E+SG++G
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
Query: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP---VQHPY 1256
DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR TL+S + HP+
Sbjct: 573 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
Query: 1257 GLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKCG- 1314
G+ + + ++WTD + +I A++ G + ++ NL D+ + QP + C
Sbjct: 633 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACEL 692
Query: 1315 --SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
NGGC +LCLP P ++CACP + L D K C +P++
Sbjct: 693 SVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS 740
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 550 bits (1417), Expect = e-156
Identities = 279/691 (40%), Positives = 380/691 (54%), Gaps = 51/691 (7%)
Query: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC--- 163
Query: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS---GL 242
A C EFQC C+ ++ CDGDDDCGD SDE C+ C EF C G
Sbjct: 164 --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD-PACGPREFRCGGDGGGA 220
Query: 243 CINAGWRCDGDADCDDQSDER------------NCTTSMCTAEQFRCHSGRCVRLSWRCD 290
CI W CD DC+D+SDE + + TA QF C SG CV L WRCD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 291 GEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
G+ DC D SDE +C C D+F C +G C+ K CN DC D SDE+ C
Sbjct: 281 GDRDCKDKSDEADCP---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCL 334
Query: 351 PRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410
G C NNGGC+ C ++ +CTC G++L D TC D++EC + CSQ C
Sbjct: 335 Q--GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICV 391
Query: 411 NSEGAFQCWCETGYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469
N +G F+C C GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 470 AIALDFHHRRELVFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKL 525
+ALD ++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 526 YWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMD 585
YWTDSG I VA +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 586 GSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHP 643
G R+ + ++ WPNG+T+D +R+YWVD+K H + + G +RK +IS L HP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 644 FAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG 703
F I VFED ++WTD ++I SAN+ G I+ L+ P DI H +QP + C
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
Query: 704 ---DNNGGCTHLCLPSGQ------NYTCACP 725
NGGC +LCLP+ Q YTCACP
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Score = 263 bits (673), Expect = 9e-70
Identities = 146/403 (36%), Positives = 204/403 (50%), Gaps = 61/403 (15%)
Query: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736
G N C NNGGC+H+C + C CP GF+ + C
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 737 ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
A L+F R ++RRI + S +IP+ +++
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR-LIPM--LKNV 452
Query: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831
VALD + + +YW D+S I A D QEV++D L SP GLA+DWV +Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
WTD+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
Query: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPF
Sbjct: 573 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
Query: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
G+ ++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 633 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 691
Query: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043
NGGC +LCL +P S ++C CP + L D K C
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 258 bits (659), Expect = 4e-68
Identities = 168/545 (30%), Positives = 271/545 (49%), Gaps = 86/545 (15%)
Query: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352
G N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 394
Query: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
E Y L+F++R +RRI L +++ + +P L N
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 451
Query: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442
V++LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502
YWTD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559
G +R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHP
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618
F + + ++WTD + ++I ++ +G + N+ DI++ +Q +AC
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
Query: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMS 1665
++ NGGC +LC + + + CACPD PD + C P A+ M+
Sbjct: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT 751
Query: 1666 EKSPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVP 1715
P P TT++ ST T T + V R A SN +
Sbjct: 752 RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQH 811
Query: 1716 AAPGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYR 1770
A + S ++ I++ +VVIA L +++R+ K K T ++ + NP YR
Sbjct: 812 YANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYR 867
Query: 1771 TSTQE 1775
+T+E
Sbjct: 868 KTTEE 872
Score = 234 bits (596), Expect = 8e-61
Identities = 131/408 (32%), Positives = 207/408 (50%), Gaps = 66/408 (16%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC---------------------- 1043
C NGGCSH+C + GF CTCP G LL D KTC
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 396
Query: 1044 --------------------SPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNT 1083
+ G + LIF R ++R + L ++ ++ +KN
Sbjct: 397 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNV 452
Query: 1084 IAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQTTDGLAVDAIGRKVY 1139
+A+ V+ ++YW D + +I A +D + + E +I L + +GLAVD + + +Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
WTD+G I V +DG R+ L +NL PRAI + GFMYW+DWG+ AK+E+SG++G
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
Query: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP---VQHPY 1256
DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR TL+S + HP+
Sbjct: 573 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
Query: 1257 GLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKCG- 1314
G+ + + ++WTD + +I A++ G + ++ NL D+ + QP + C
Sbjct: 633 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACEL 692
Query: 1315 --SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
NGGC +LCLP P ++CACP + L D K C +P++
Sbjct: 693 SVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS 740
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 454 bits (1167), Expect = e-127
Identities = 230/559 (41%), Positives = 321/559 (57%), Gaps = 28/559 (5%)
Query: 187 PAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
PA C ++FQC RCI ++ CD DDDC D SDE DC + C +F CD+G CI+
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK-KTCADSDFTCDNGHCIHE 101
Query: 247 GWRCDGDADCDDQSDERN--CTTSMCTAEQFRCH--SGRCVRLSWRCDGEDDCADNSDEE 302
W+CDG+ +C D SDE CT +C AE+ C S +CV SWRCDGE DC +DE
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 303 NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN 362
C T C D+F C +G C+ K CN DC D SDE+ C G C NN
Sbjct: 162 GCA-TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCLQ--GLNECLHNN 215
Query: 363 GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCET 422
GGC+ C ++ +CTC G++L D TC D++EC + CSQ C N +G F+C C
Sbjct: 216 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
Query: 423 GYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRREL 481
GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N +ALD
Sbjct: 275 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 334
Query: 482 VFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEV 537
++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +YWTDSG I V
Sbjct: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394
Query: 538 ANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHL 597
A +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++G R+ + ++
Sbjct: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454
Query: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYW 655
WPNG+T+D +R+YWVD+K H + + G +RK +IS L HPF I VFED ++W
Sbjct: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514
Query: 656 TDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG---DNNGGCTHL 712
TD ++I SAN+ G I+ L+ P DI H +QP + C NGGC +L
Sbjct: 515 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 574
Query: 713 CLPSGQ------NYTCACP 725
CLP+ Q YTCACP
Sbjct: 575 CLPAPQISSHSPKYTCACP 593
Score = 265 bits (676), Expect = 4e-70
Identities = 148/427 (34%), Positives = 211/427 (49%), Gaps = 61/427 (14%)
Query: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736
G N C NNGGC+H+C + C CP GF+ + C
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
Query: 737 ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
A L+F R ++RRI + S +IP+ +++
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR-LIPM--LKNV 323
Query: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831
VALD + + +YW D+S I A D QEV++D L SP GLA+DWV +Y
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
WTD+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 384 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 443
Query: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPF
Sbjct: 444 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 503
Query: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
G+ ++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 504 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 562
Query: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIR 1060
NGGC +LCL +P S ++C CP + L D K C N +
Sbjct: 563 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAA 622
Query: 1061 MVSLDIP 1067
++ + +P
Sbjct: 623 VIGIIVP 629
Score = 237 bits (605), Expect = 7e-62
Identities = 134/403 (33%), Positives = 216/403 (53%), Gaps = 67/403 (16%)
Query: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352
G N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 265
Query: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
E Y L+F++R +RRI L +++ + +P L N
Sbjct: 266 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 322
Query: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442
V++LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++
Sbjct: 323 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
Query: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502
YWTD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+
Sbjct: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
Query: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559
G +R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHP
Sbjct: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 502
Query: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618
F + + ++WTD + ++I ++ +G + N+ DI++ +Q +AC
Sbjct: 503 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 562
Query: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPC 1648
++ NGGC +LC + + + CACPD PD + C
Sbjct: 563 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 231 bits (590), Expect = 4e-60
Identities = 130/402 (32%), Positives = 203/402 (50%), Gaps = 66/402 (16%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC---------------------- 1043
C NGGCSH+C + GF CTCP G LL D KTC
Sbjct: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 267
Query: 1044 --------------------SPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNT 1083
+ G + LIF R ++R + L ++ ++ +KN
Sbjct: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNV 323
Query: 1084 IAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQTTDGLAVDAIGRKVY 1139
+A+ V+ ++YW D + +I A +D + + E +I L + +GLAVD + + +Y
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
WTD+G I V +DG R+ L +NL PRAI + GFMYW+DWG+ AK+E+SG++G
Sbjct: 384 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 443
Query: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP---VQHPY 1256
DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR TL+S + HP+
Sbjct: 444 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 503
Query: 1257 GLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKCG- 1314
G+ + + ++WTD + +I A++ G + ++ NL D+ + QP + C
Sbjct: 504 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACEL 563
Query: 1315 --SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTC 1348
NGGC +LCLP P ++CACP + L D K C
Sbjct: 564 SVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 158 bits (400), Expect = 4e-38
Identities = 68/160 (42%), Positives = 91/160 (56%), Gaps = 7/160 (4%)
Query: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C ++
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS 166
Query: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDC 225
+ C +EFQC G C+L I HC+ + DC D SDE+ C
Sbjct: 167 LGT--CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 150 bits (380), Expect = 9e-36
Identities = 82/237 (34%), Positives = 109/237 (45%), Gaps = 28/237 (11%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK 82
P C + F C CIP+ W+CD D+DC DHSDED C TC+ DF CDNG
Sbjct: 43 PAKDCEKDQFQCRNER-----CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH 97
Query: 83 CIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPC--QNGYCIRSLWHCDGDNDCGDN 138
CI W CDG+ +C D SDE + C + C ++ C + C+ + W CDG+ DC
Sbjct: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 139 SDE---QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLE- 194
+DE + C EF+C DG+C+ +C+ + DC DGSDE C + N
Sbjct: 158 ADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGG 217
Query: 195 ------------EFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
E C G +LD C D+C D CS G F C+
Sbjct: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKCE 271
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 413 bits (1061), Expect = e-115
Identities = 213/559 (38%), Positives = 301/559 (53%), Gaps = 69/559 (12%)
Query: 187 PAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
PA C ++FQC RCI ++ CD DDDC D SDE DC + C +F CD+G CI+
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK-KTCADSDFTCDNGHCIHE 101
Query: 247 GWRCDGDADCDDQSD--ERNCTTSMCTAEQFRC--HSGRCVRLSWRCDGEDDCADNSDEE 302
W+CDG+ +C D SD E CT +C AE+ C S +CV SWRCDGE DC +DE
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 303 NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN 362
C W C+ NN
Sbjct: 162 GCAT-------------WLNECLH----------------------------------NN 174
Query: 363 GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCET 422
GGC+ C ++ +CTC G++L D TC D++EC + CSQ C N +G F+C C
Sbjct: 175 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 233
Query: 423 GYELRPDRRSCK-ALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRREL 481
GYE+ ++CK A G P L+F NR ++R++ + Y+ L+ L+N +ALD
Sbjct: 234 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 293
Query: 482 VFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEV 537
++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +YWTDSG I V
Sbjct: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353
Query: 538 ANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHL 597
A +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++G R+ + ++
Sbjct: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413
Query: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYW 655
WPNG+T+D +R+YWVD+K H + + G +RK +IS L HPF I VFED ++W
Sbjct: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473
Query: 656 TDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG---DNNGGCTHL 712
TD ++I SAN+ G I+ L+ P DI H +QP + C NGGC +L
Sbjct: 474 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 533
Query: 713 CLPSGQ------NYTCACP 725
CLP+ Q YTCACP
Sbjct: 534 CLPAPQISSHSPKYTCACP 552
Score = 262 bits (669), Expect = 3e-69
Identities = 145/401 (36%), Positives = 203/401 (50%), Gaps = 61/401 (15%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC----------------------- 736
N C NNGGC+H+C + C CP GF+ + C
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 737 -------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVA 777
A L+F R ++RRI + S +IP+ +++ VA
Sbjct: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR-LIPM--LKNVVA 284
Query: 778 LDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLYWT 833
LD + + +YW D+S I A D QEV++D L SP GLA+DWV +YWT
Sbjct: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
Query: 834 DAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASG 893
D+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 345 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 404
Query: 894 RQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGL 951
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPFG+
Sbjct: 405 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 464
Query: 952 TLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME-- 1009
++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 465 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACELS 523
Query: 1010 ---NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043
NGGC +LCL +P S ++C CP + L D K C
Sbjct: 524 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 256 bits (653), Expect = 2e-67
Identities = 167/543 (30%), Positives = 270/543 (49%), Gaps = 86/543 (15%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP----------- 1352
N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 226
Query: 1353 ---ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNNVI 1388
E Y L+F++R +RRI L +++ + +P L NV+
Sbjct: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKNVV 283
Query: 1389 SLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNLYW 1444
+LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++YW
Sbjct: 284 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 343
Query: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
TD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+G
Sbjct: 344 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 403
Query: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHPFA 1561
+R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHPF
Sbjct: 404 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 463
Query: 1562 LTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACGVN 1620
+ + ++WTD + ++I ++ +G + N+ DI++ +Q +AC ++
Sbjct: 464 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 523
Query: 1621 ---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMSEK 1667
NGGC +LC + + + CACPD PD + C P A+ M+
Sbjct: 524 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 583
Query: 1668 SPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVPAA 1717
P P TT++ ST T T + V R A SN + A
Sbjct: 584 VPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYA 643
Query: 1718 PGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYRTS 1772
+ S ++ I++ +VVIA L +++R+ K K T ++ + NP YR +
Sbjct: 644 NEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYRKT 699
Query: 1773 TQE 1775
T+E
Sbjct: 700 TEE 702
Score = 234 bits (596), Expect = 8e-61
Identities = 131/408 (32%), Positives = 207/408 (50%), Gaps = 66/408 (16%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC---------------------- 1043
C NGGCSH+C + GF CTCP G LL D KTC
Sbjct: 170 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 226
Query: 1044 --------------------SPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNT 1083
+ G + LIF R ++R + L ++ ++ +KN
Sbjct: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNV 282
Query: 1084 IAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQTTDGLAVDAIGRKVY 1139
+A+ V+ ++YW D + +I A +D + + E +I L + +GLAVD + + +Y
Sbjct: 283 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 342
Query: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
WTD+G I V +DG R+ L +NL PRAI + GFMYW+DWG+ AK+E+SG++G
Sbjct: 343 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 402
Query: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP---VQHPY 1256
DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR TL+S + HP+
Sbjct: 403 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 462
Query: 1257 GLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKCG- 1314
G+ + + ++WTD + +I A++ G + ++ NL D+ + QP + C
Sbjct: 463 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACEL 522
Query: 1315 --SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
NGGC +LCLP P ++CACP + L D K C +P++
Sbjct: 523 SVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS 570
Score = 124 bits (310), Expect = 1e-27
Identities = 65/187 (34%), Positives = 85/187 (45%), Gaps = 21/187 (11%)
Query: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C +
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
Query: 186 VPAPPCNLE-------------EFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCR 232
+ N E C G +LD C D+C D CS
Sbjct: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNY 223
Query: 233 SGEFMCD 239
G F C+
Sbjct: 224 KGYFKCE 230
Score = 35.8 bits (81), Expect = 0.41
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 1612 TGTNACGVNNGGCTHLCFARASDFVCACP 1640
T N C NNGGC+H+C F C CP
Sbjct: 165 TWLNECLHNNGGCSHICTDLKIGFECTCP 193
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 293 bits (750), Expect = 1e-78
Identities = 162/428 (37%), Positives = 235/428 (54%), Gaps = 14/428 (3%)
Query: 357 NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTN-SEGA 415
+C N C+ C + C C G L DG TC + + G CSQ C S +
Sbjct: 400 SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS-PDNGGCSQLCVPLSPVS 458
Query: 416 FQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEY-TLLLNNLENAIALD 474
++C C GY+L+ D +SC A GP+P LLFAN DIR + ++Y TLL + ALD
Sbjct: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALD 518
Query: 475 FHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSR 534
++++ L I RAN++GS E ++ G++ P GLAVDW+ + YWTD G S
Sbjct: 519 HDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSL 578
Query: 535 IEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIAD 594
I ++L+G K++ +N+ +PR IA+HPM ++WTD G PRIE+SS+ G GR +IA
Sbjct: 579 IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIAS 638
Query: 595 THLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLY 654
+ L WP+G+TID+ ++YW DAK VIE ANLDGS R+ + + HPFA+ VFED ++
Sbjct: 639 SDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVW 698
Query: 655 WTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL 714
++DW S+ NK TGK++ ++ + P + +HP +P G + C NGGC H+C
Sbjct: 699 FSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP-GADPCLYQNGGCEHICK 757
Query: 715 PSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRS 774
C+C GF K S +LD L A DL + V PL D+ S
Sbjct: 758 KRLGTAWCSCREGFMKASDGKTCLALDGHQLLAG---------GEVDLKNQVTPL-DILS 807
Query: 775 AVALDWDS 782
+ D+
Sbjct: 808 KTRVSEDN 815
Score = 253 bits (645), Expect = 2e-66
Identities = 195/789 (24%), Positives = 333/789 (42%), Gaps = 157/789 (19%)
Query: 436 LGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRA 495
+GP P L+F++ I ++ + Y L+ + ++ +DFH+ + ++W D+ + R
Sbjct: 42 VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRV 101
Query: 496 NLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEK 555
LNGS E V + ++ G+A++W+++++ W++ I V ++ G + +LL L+
Sbjct: 102 FLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
Query: 556 PRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWV 615
P +A+ P+E I+W+ + + +DG G + + +T +++D +R++W+
Sbjct: 160 PANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWI 217
Query: 616 ----DAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG 671
+ + +I + DG + FA+++F D ++++ W K+I ANK TG
Sbjct: 218 QYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Query: 672 KNQEIIRNKLHFPM----DIHTLHPQRQPAGK---------------------------- 699
K +++R LH ++ +HP QP +
Sbjct: 278 K--DMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQ 335
Query: 700 ----------------------NRCGDNNGGCTHLCLPSGQNYTCACPTGF--------- 728
N C N GCT C + +Y C CP GF
Sbjct: 336 SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Query: 729 -------RKIS--SHACAQSLDKFLLFARRMDIRR---------ISFDTEDLSDDVIPLA 770
R +S SH C + + L F + S D S +PL+
Sbjct: 396 HQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLS 455
Query: 771 ------DVRSAVALDWDSRD-----DHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPA 819
D L D + + ++ I +DGT ++ +
Sbjct: 456 PVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVY 515
Query: 820 GLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLI-------------W----------- 855
L D V NK+Y+ IE AN DGS R LI W
Sbjct: 516 ALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRG 575
Query: 856 -------------------ENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQV 896
EN+ +PR I V PM ++WTD G +P+IE + + GR V
Sbjct: 576 KSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLV 635
Query: 897 IISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGE 956
I SS+L WP+G+ ID+ + +LYW DA IE A LDGSKR+ L + + HPF + ++ +
Sbjct: 636 IASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFED 695
Query: 957 RIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHL 1016
++++DW S+ ++ TG DR LQ ++ + V H P + PC +NGGC H+
Sbjct: 696 YVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHI 755
Query: 1017 CLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPI 1076
C + + C+C G SDGKTC L+ +D++ + V P+
Sbjct: 756 CKKRLGTAW--CSCREGFMKASDGKTCLALDGHQLLAGGEVDLK----------NQVTPL 803
Query: 1077 NITMKNTIA 1085
+I K ++
Sbjct: 804 DILSKTRVS 812
Score = 239 bits (610), Expect = 2e-62
Identities = 124/344 (36%), Positives = 200/344 (58%), Gaps = 9/344 (2%)
Query: 1317 NGGCSHLCLP-RPSGFSCACPTGIQLKGDGKTCDPS-PETYLLFSSRGSIRRISLDTSDH 1374
NGGCS LC+P P + C C G L+ D K+C S P+ +LLF++ IR + D +D+
Sbjct: 444 NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDY 503
Query: 1375 TDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLA 1434
+ ++ V +LD+D V+ K+Y+ L I RA+++GS E +I G+ +GLA
Sbjct: 504 GTLLSQ--QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 1435 VDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA 1494
VDW+ R YWTD G++ I S L+G K++ ++ +PR IAV P LFWTD G
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 1495 KIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNG-KLRQVLV 1553
+IE ++L G R V+ ++DL WP+G+T+D+ T ++YW DA IE A+L+G K R++
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 1554 SHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTG 1613
+ V HPFA+ + +++++DW S+ RV+K +G+++ + ++ ++VV P + G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 1614 TNACGVNNGGCTHLCFARASDFVCACPD----EPDSRPCSLVPG 1653
+ C NGGC H+C R C+C + D + C + G
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDG 785
Score = 229 bits (583), Expect = 3e-59
Identities = 121/342 (35%), Positives = 190/342 (55%), Gaps = 6/342 (1%)
Query: 1009 ENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSP-GMNSFLIFARRIDIRMVSLDIP 1067
+NGGCS LC+ +P + C C G +L D K+C+ G FL+FA DIR + D
Sbjct: 443 DNGGCSQLCVPL-SPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFD-- 499
Query: 1068 YFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD 1127
D ++ M A+ DP E K+Y++ + L I RAN+DGSQ E +I G+ +
Sbjct: 500 -GTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558
Query: 1128 GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG 1187
GLAVD IGR+ YWTD G + I +L+G K++ +N+ PR I ++ ++WTD G
Sbjct: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTG 618
Query: 1188 ENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHT 1247
N ++E S + G R V+ +++L WP+G+T+D + +L W DA IE A+L+G+ R
Sbjct: 619 INPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 1248 LV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQ 1306
L + V HP+ + + + Y++++DW S+ R +K TG + + ++ ++ + V
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
Query: 1307 PLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
G + C +NGGC H+C R C+C G DGKTC
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Score = 105 bits (261), Expect = 6e-22
Identities = 88/378 (23%), Positives = 163/378 (43%), Gaps = 66/378 (17%)
Query: 723 ACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDS 782
+CP G + ++ FL+F+ I RI DTE + + + + D +V +D+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRI--DTEGTNYEQL-VVDAGVSVIMDFHY 83
Query: 783 RDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEV 842
+ +YW D+ + R +G+ QE V + ++ +G+AI+W+ ++ W++ I V
Sbjct: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 843 ANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVII--SS 900
+ G+ +L+ L P ++ V+P+ +++W+ A + RA +D G + ++ S
Sbjct: 143 TDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETSE 200
Query: 901 NLTWPNGLAIDYGSQRLYWA----DAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGE 956
+T +++D +RL+W + I DG + + F ++L+G+
Sbjct: 201 KIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGD 257
Query: 957 RIYWTDWQTKSIQSADRLTGLD--RETLQENLENLMDIHVFHRRRPPVSTP--------- 1005
RI+++ W+ K+I A++ TG D R L + L ++ V H P +
Sbjct: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKL 317
Query: 1006 CAMENGGC----------SHLCLRSP------------------------------NPSG 1025
C + G C SHLC+ + P
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
Query: 1026 FSCTCPTGINLLSDGKTC 1043
+ CTCP G LL DGK C
Sbjct: 378 YYCTCPVGFVLLPDGKRC 395
Score = 93.2 bits (230), Expect = 2e-18
Identities = 83/340 (24%), Positives = 157/340 (46%), Gaps = 31/340 (9%)
Query: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP 1380
S + L P +SC P G L G+G + P +L+FS SI RI + +++ +
Sbjct: 16 SFVSLSAPQHWSC--PEGT-LAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL--- 69
Query: 1381 VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR 1440
V + + +D+ + ++Y+ D+ +++R LNGS E V K G+A++W+
Sbjct: 70 VVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINE 128
Query: 1441 NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN 1500
+ W++ I + + G+ +L+ ++L P +AV P + ++FW+ + RA+
Sbjct: 129 EVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRAD 186
Query: 1501 LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLD----RIESADLNGKLRQVLVSHV 1556
LDG K L+ T ++LD +R++W+ + + I S D +G +
Sbjct: 187 LDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPT 245
Query: 1557 SHP-FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEG----LMDIIVVSPQRQ 1611
H FA++ I+++ W+ K+I +K++G K+ V N+ L ++ VV P Q
Sbjct: 246 QHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG--KDMVRINLHSSFVPLGELKVVHPLAQ 303
Query: 1612 TGT---------NACGVNNGGCTH-LCFARASDFVCACPD 1641
C + G C+ +C +C C +
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAE 343
Score = 65.5 bits (158), Expect = 5e-10
Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 339 DNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNE 398
D++ E Q+ C+ R G N ++ C Q Q + C C GY L+ D C+DVNE
Sbjct: 308 DDTWEPEQKLCKLRKG----NCSSTVCGQDLQ----SHLCMCAEGYALSRDRKYCEDVNE 359
Query: 399 CAEEGY-CSQGCTNSEGAFQCWCETGYELRPDRRSCKAL 436
CA + C+ GC N+ G++ C C G+ L PD + C L
Sbjct: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
Score = 53.5 bits (127), Expect = 2e-06
Identities = 38/147 (25%), Positives = 76/147 (51%), Gaps = 10/147 (6%)
Query: 1181 MYWTDWGENAKLERSGMDGS--DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
+YW D E L+R ++GS +R I N+ +G+ ++ + +++W++ I
Sbjct: 88 IYWVDL-ERQLLQRVFLNGSRQERVCNIEKNV---SGMAINWINEEVIWSNQQEGIITVT 143
Query: 1239 DLNGANRHTLVSPVQHPYGLTL--LDSYIYWTDWQTRSIHRAD-KGTGSNVILVRSNLPG 1295
D+ G N H L+S +++P + + ++ +I+W+ S++RAD G G +L S
Sbjct: 144 DMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT 203
Query: 1296 LMDMQAVD-RAQPLGFNKCGSRNGGCS 1321
+ + +D R + +N+ GS + CS
Sbjct: 204 AVSLDVLDKRLFWIQYNREGSNSLICS 230
Score = 45.8 bits (107), Expect = 4e-04
Identities = 30/98 (30%), Positives = 41/98 (41%), Gaps = 23/98 (23%)
Query: 326 GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYR 385
G KLC+ +++C E C P + KC G C C GY+
Sbjct: 863 GDGKLCSDIDEC-----EMGVPVCPP-------------ASSKCINTEGGYVCRCSEGYQ 904
Query: 386 LTEDGHTCQDVNECA-EEGYCSQG--CTNSEGAFQCWC 420
DG C D++EC E C + CTN+EG + C C
Sbjct: 905 --GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
Score = 41.6 bits (96), Expect = 0.007
Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 6/67 (8%)
Query: 364 GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY-----CSQGCTNSEGAFQC 418
GC+ + + TC DG C D++EC E G S C N+EG + C
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVC 897
Query: 419 WCETGYE 425
C GY+
Sbjct: 898 RCSEGYQ 904
Score = 39.7 bits (91), Expect = 0.028
Identities = 15/42 (35%), Positives = 20/42 (47%)
Query: 352 RTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
+ G + C NGGC C+ G C+C G+ DG TC
Sbjct: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Score = 35.8 bits (81), Expect = 0.41
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 1/61 (1%)
Query: 1080 MKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVY 1139
+K + VDP E ++WS + RA+LDG + ++ T + T +++D + ++++
Sbjct: 157 LKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT-AVSLDVLDKRLF 215
Query: 1140 W 1140
W
Sbjct: 216 W 216
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 275 bits (704), Expect = 2e-73
Identities = 157/419 (37%), Positives = 207/419 (49%), Gaps = 61/419 (14%)
Query: 30 SHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWV 89
+ F C S TCIP ++CD ++DCGD+SDE C + C +++C +G CIR SWV
Sbjct: 1121 TQFRCQESG----TCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176
Query: 90 CDGDNDCEDDSDEQDCPP--RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE---QCD 144
CDGDNDC D SDE +C CE F C+NG+CI W CDGD DC D SDE C+
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
Query: 145 MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPC-NLEEFQCA-YGR 202
+KC+ FRC +G+CI +CDG DC DGSDE++C P C + +F C +
Sbjct: 1237 -KKCNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-----EPLCTHFMDFVCKNRQQ 1288
Query: 203 CILDIYHCDGDDDCGDWSDE----SDCSS----HQPCRSGEFMCDSGLCINAGWRCDGDA 254
C+ CDG C D SDE + CS H+ C F C +G+CI+ W+CDG
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
Query: 255 DCDDQSDERNCTTSM----CTAE-QFRCHSGRCVRLSWRCDGEDDCADNSDEENCENT-- 307
DC D SDE NC C+ QFRC +G C+ W+CD E+DC D SDE++C ++
Sbjct: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHI 1408
Query: 308 ------GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE-------------SPQQN 348
G C + + C +G C+ +C+G DC D SDE +P Q
Sbjct: 1409 LPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQL 1468
Query: 349 CRPRTGEENC--------NVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC 399
R E C N Q CQ R C H+ C+D C
Sbjct: 1469 GRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEAC 1527
Score = 269 bits (688), Expect = 2e-71
Identities = 150/341 (43%), Positives = 184/341 (53%), Gaps = 36/341 (10%)
Query: 24 ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCS-PLDFHC-DNG 81
E C R+ + C+ CI + W CD DNDCGD SDE C C F C ++G
Sbjct: 1075 ENTCLRNQYRCSNG-----NCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESG 1129
Query: 82 KCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
CI S+ CD ++DC D+SDE C +C DE+ C +G CIRS W CDGDNDC D SDE
Sbjct: 1130 TCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Query: 142 -QCD--MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE--NCPSAVPAPPCNLEEF 196
C C F+C +G CI + W CDGDTDC+DGSDE+ NC CN F
Sbjct: 1190 ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK-----KCN--GF 1242
Query: 197 QCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSG--EFMC-DSGLCINAGWRCDGD 253
+C G CI HCDG DC D SDE C +P + +F+C + C+ CDG
Sbjct: 1243 RCPNGTCIPSSKHCDGLRDCSDGSDEQHC---EPLCTHFMDFVCKNRQQCLFHSMVCDGI 1299
Query: 254 ADCDDQSDE----RNCTT-----SMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
C D SDE C+ +C F+C +G C+ L W+CDG DDC D SDE NC
Sbjct: 1300 IQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Query: 305 EN-TGSPQCA-LDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
EN T +P C+ QF C NG CI R C+ NDCGD SDE
Sbjct: 1360 ENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Score = 254 bits (650), Expect = 4e-67
Identities = 144/380 (37%), Positives = 173/380 (45%), Gaps = 83/380 (21%)
Query: 44 CIPAQWQCDGDNDCGDHSDEDGC--ILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSD 101
CI + W CDGDNDC D SDE C I TC +F C NG CI + W CDGD DC+D SD
Sbjct: 1170 CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSD 1229
Query: 102 EQDCPPRECEE--DEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ----------------- 142
E P CE+ + F C NG CI S HCDG DC D SDEQ
Sbjct: 1230 ED---PVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNR 1286
Query: 143 ---------CD------------------------MRKCSDKEFRCSDGSCIAEHWYCDG 169
CD + C + F+C +G CI+ W CDG
Sbjct: 1287 QQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDG 1346
Query: 170 DTDCKDGSDEENCPSAVPAPPCNLE-EFQCAYGRCILDIYHCDGDDDCGDWSDESDCS-S 227
DC D SDE NC + AP C+ +F+C G CI + + CD ++DCGDWSDE DC S
Sbjct: 1347 MDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDS 1406
Query: 228 H---------QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTT----------- 267
H C + C SG C+ W CDG DC D SDE C
Sbjct: 1407 HILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPT 1466
Query: 268 --SMCTAEQFRCHSGRCVRLSW-RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGR- 323
C +F CH + +W RCDG DC D DE NC + C +F C +G
Sbjct: 1467 QLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEA 1526
Query: 324 CIGQRKLCNGVNDCGDNSDE 343
CI + C+G DC D SDE
Sbjct: 1527 CIVLSERCDGFLDCSDESDE 1546
Score = 217 bits (553), Expect = 8e-56
Identities = 134/368 (36%), Positives = 166/368 (45%), Gaps = 86/368 (23%)
Query: 22 SPECACGRSHFTCAVSALGECT---CIPAQWQCDGDNDCGDHSDEDGCILPT-CSPLDFH 77
S E C + TC S +C CIP +W CDGD DC D SDED C+ F
Sbjct: 1187 SDEANCTAIYHTCEASNF-QCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN--GFR 1243
Query: 78 CDNGKCIRRSWVCDGDNDCEDDSDEQDCPP------------------------------ 107
C NG CI S CDG DC D SDEQ C P
Sbjct: 1244 CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
Query: 108 -------------------RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ-----C 143
+ C+E F CQNG CI +W CDG +DCGD SDE
Sbjct: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
Query: 144 DMRKCSDK-EFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPP-CNLEE 195
+ CS +FRC +G CI W CD + DC D SDE++C P + P P C
Sbjct: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNY 1423
Query: 196 FQCAYGRCILDIYHCDGDDDCGDWSDESDC-------SSHQPCRSG-----EFMCDSGLC 243
++C+ G C++D + CDG DC D SDE C ++ P + G EF C
Sbjct: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
Query: 244 INAGW-RCDGDADCDDQSDERNC---TTSMCTAEQFRCHSGR-CVRLSWRCDGEDDCADN 298
W RCDG DC D DE NC +T C + +F+C G C+ LS RCDG DC+D
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
Query: 299 SDEENCEN 306
SDE+ C +
Sbjct: 1544 SDEKACSD 1551
Score = 215 bits (547), Expect = 4e-55
Identities = 128/358 (35%), Positives = 195/358 (54%), Gaps = 42/358 (11%)
Query: 712 LCLP----SGQNYT--CACPTG--------FRKISSHACA-----------------QSL 740
+C+P SG++Y+ CP G +RKIS C+
Sbjct: 698 VCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEE 757
Query: 741 DKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800
++F+L+A R I R +D + + +PL +R+AVALD+D + +YW+D++ D I R
Sbjct: 758 NEFILYAVRKSIYR--YDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRL 815
Query: 801 KWDG-TGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWEN-L 858
+G TGQEV++++ LE+ LA + ++ LYW DAG +IEVAN DG R ++ + L
Sbjct: 816 CLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVL 875
Query: 859 DRPRDIVVEPMGGYMYWTDWG-ASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRL 917
DRPR +V+ P G M+WTDWG P I R+ MD S ++S ++ WPNG+++D Q +
Sbjct: 876 DRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWI 933
Query: 918 YWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGL 977
YW DA ++ IE G +R V++ + LPHP+ + ++ IYW DW SI A + +G
Sbjct: 934 YWTDAYLECIERITFSGQQRSVILDN-LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
Query: 978 DRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGIN 1035
E L L LMD+ +F++ + S C CS LCL N S SC CP ++
Sbjct: 993 QMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSR-SCRCPEDVS 1047
Score = 207 bits (528), Expect = 6e-53
Identities = 119/301 (39%), Positives = 156/301 (51%), Gaps = 47/301 (15%)
Query: 58 GDHSDEDGCILPTCSPLDF-HCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP 116
G ++ + C+ CS L +N + R C +D P + D
Sbjct: 1013 GKNTGSNACVPRPCSLLCLPKANNSRSCR----------CPEDVSSSVLPSGDLMCD--- 1059
Query: 117 CQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDG 176
C GY +++ +N C N ++RCS+G+CI W+CD D DC D
Sbjct: 1060 CPQGYQLKNNTCVKEENTCLRN-------------QYRCSNGNCINSIWWCDFDNDCGDM 1106
Query: 177 SDEENCPSAVPAPPCNLE-EFQC-AYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSG 234
SDE NCP+ + C+L+ +F+C G CI Y CD +DDCGD SDES C HQ CRS
Sbjct: 1107 SDERNCPTTI----CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ-CRSD 1161
Query: 235 EFMCDSGLCINAGWRCDGDADCDDQSDERNCTT--SMCTAEQFRCHSGRCVRLSWRCDGE 292
E+ C SG+CI + W CDGD DC D SDE NCT C A F+C +G C+ W CDG+
Sbjct: 1162 EYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGD 1221
Query: 293 DDCADNSDEE--NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
DC D SDE+ NCE +C + F C NG CI K C+G+ DC D SDE Q+C
Sbjct: 1222 TDCQDGSDEDPVNCEK----KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDE---QHCE 1272
Query: 351 P 351
P
Sbjct: 1273 P 1273
Score = 206 bits (523), Expect = 2e-52
Identities = 117/311 (37%), Positives = 184/311 (59%), Gaps = 11/311 (3%)
Query: 1340 QLKGDGKTCDPSPET-YLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGK 1398
+L+G+ C + E ++L++ R SI R L S T+ +P+ L ++LD+D
Sbjct: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDL-ASGATE-QLPLTGLRAAVALDFDYEHNC 801
Query: 1399 VYYTDVFLDVIRRADLNGSN-METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRL 1457
+Y++D+ LDVI+R LNGS E +I GL+T + LA + +++ LYW D G IE +
Sbjct: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
Query: 1458 DGSCRKVLINNS-LDEPRAIAVFPRKGYLFWTDWGHIAK-IERANLDGSERKVLINTDLG 1515
DG R ++N+S LD PRA+ + P++G +FWTDWG + I R+N+DGS L++ D+
Sbjct: 862 DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921
Query: 1516 WPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQ 1575
WPNG+++D + IYW DA+L+ IE +G+ R V++ ++ HP+A+ IYW DW
Sbjct: 922 WPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWS 979
Query: 1576 TKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDF 1635
SI R KYSG E + + GLMD+ + + TG+NAC C+ LC +A++
Sbjct: 980 QLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNS 1037
Query: 1636 -VCACPDEPDS 1645
C CP++ S
Sbjct: 1038 RSCRCPEDVSS 1048
Score = 196 bits (498), Expect = 2e-49
Identities = 117/298 (39%), Positives = 166/298 (55%), Gaps = 11/298 (3%)
Query: 433 CKALGPEPVLLFANRIDI-RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDR 491
C +L+A R I R L + L L L A+ALDF + ++WSD+ LD
Sbjct: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
Query: 492 ILRANLNGSNVEEVV-STGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLW 550
I R LNGS +EV+ ++GLE+ LA + + LYW D+G +IEVAN DG R ++
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 551 QN-LEKPRAIALHPMEGTIYWTDWGNT-PRIEASSMDGSGRRIIADTHLFWPNGLTIDYA 608
+ L++PRA+ L P EG ++WTDWG+ P I S+MDGS + + WPNG+++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 609 GRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANK 668
+ +YW DA IER G R +VI LPHP+AI VF++ +YW DW SI A+K
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQR-SVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 669 FTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN-YTCACP 725
++G EI+ N+L MD+ + + G N C C+ LCLP N +C CP
Sbjct: 989 YSGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR--PCSLLCLPKANNSRSCRCP 1043
Score = 193 bits (490), Expect = 2e-48
Identities = 132/391 (33%), Positives = 190/391 (48%), Gaps = 59/391 (15%)
Query: 1016 LCLRSPNPSGFSCT----CPTGINLLS-------DGKTCSPG-----------------M 1047
+C+ P SG S + CP G G TCS G
Sbjct: 698 VCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEE 757
Query: 1048 NSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISR 1107
N F+++A R I D+ A +P+ ++ +A+ D + +YWSD L I R
Sbjct: 758 NEFILYAVRKSI--YRYDLASGATEQLPLT-GLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 1108 ANLDGSQHED-IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQN- 1165
L+GS ++ II +GL+T + LA + + + +YW D G +IEV N DG R +V +
Sbjct: 815 LCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSV 874
Query: 1166 LDSPRAIVLYHEMGFMYWTDWGE-NAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQ 1224
LD PRA+VL + G M+WTDWG+ + RS MDGS L++ ++ WPNG++VD
Sbjct: 875 LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQW 932
Query: 1225 LLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGS 1284
+ W DA+ E IE +G R ++ + HPY + + + IYW DW SI RA K +GS
Sbjct: 933 IYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
Query: 1285 NVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPR----------------- 1327
+ ++ + L GLMDM+ + + G N C R CS LCLP+
Sbjct: 993 QMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDVSSSV 1050
Query: 1328 -PSG-FSCACPTGIQLKGDGKTCDPSPETYL 1356
PSG C CP G QLK + TC T L
Sbjct: 1051 LPSGDLMCDCPQGYQLKNN--TCVKEENTCL 1079
Score = 189 bits (479), Expect = 3e-47
Identities = 106/265 (40%), Positives = 132/265 (49%), Gaps = 39/265 (14%)
Query: 44 CIPAQWQCDGDNDCGDHSDED----GC-----ILPTCSPLDFHCDNGKCIRRSWVCDGDN 94
C+ CDG C D SDED GC C F C NG CI W CDG +
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
Query: 95 DCEDDSDEQDCP-----PRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ-CD---- 144
DC D SDE +C P +F C+NG+CI + W CD +NDCGD SDE+ C
Sbjct: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHI 1408
Query: 145 -------MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP-----SAVPAPP-- 190
C +RCS G+C+ + W CDG DC DGSDEE CP +A P
Sbjct: 1409 LPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQL 1468
Query: 191 --CNLEEFQCAYGR-CILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMCDSG-LCI 244
C+ EF+C + CI + CDG DC D DE++C +H C S EF C+ G CI
Sbjct: 1469 GRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACI 1528
Query: 245 NAGWRCDGDADCDDQSDERNCTTSM 269
RCDG DC D+SDE+ C+ +
Sbjct: 1529 VLSERCDGFLDCSDESDEKACSDEL 1553
Score = 131 bits (329), Expect = 7e-30
Identities = 74/204 (36%), Positives = 99/204 (48%), Gaps = 27/204 (13%)
Query: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAE-QFRC-HSGRCVRLSWR 288
C ++ C +G CIN+ W CD D DC D SDERNC T++C + QFRC SG C+ LS++
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN 348
CD EDDC DNSDE +CE QC D++ C +G CI +C+G NDC D SDE+
Sbjct: 1138 CDLEDDCGDNSDESHCE---MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
Query: 349 CRPRTGEENCNVNNGGCAQKCQMVRGAVQC------------------TCHTGYRLTEDG 390
N NG C + G C C G +
Sbjct: 1195 IYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSK 1254
Query: 391 HTCQDVNEC---AEEGYCSQGCTN 411
H C + +C ++E +C CT+
Sbjct: 1255 H-CDGLRDCSDGSDEQHCEPLCTH 1277
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 208 bits (530), Expect = 4e-53
Identities = 132/393 (33%), Positives = 165/393 (41%), Gaps = 69/393 (17%)
Query: 11 GALLCAHGLASSPECAC--GRSHF---TCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG 65
G LL C C GR+ F + G CTC QW C GD G H +E
Sbjct: 1317 GTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGD---GGHCEE-- 1371
Query: 66 CILPTCSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIR 124
++P C+ + C +NG C+ W+CD +DC D SDE+ C C E + C +G+C+
Sbjct: 1372 -LVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLP 1430
Query: 125 SLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPS 184
CD +DCGD +DE C C+DG C+ CDG DC D +DEE+C
Sbjct: 1431 LALLCDRQDDCGDGTDE--PSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 185 AVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE---------------------- 222
V P E C G C+ I CDG DC D +DE
Sbjct: 1489 QVTCVP---GEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPS 1545
Query: 223 -----------SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCT 271
+ S PC EF C SG C GWRCD + DC D SDER C C
Sbjct: 1546 PGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCA 1604
Query: 272 AEQFRCHSG-RCVRLSWRCDGEDDCADNSDE--ENC---------ENTGSPQCALDQFLC 319
C G CV CDG C D SDE + C TG P ++ C
Sbjct: 1605 PHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLP---CPEYTC 1661
Query: 320 WNGRCIGQRKLCNGVNDCGDNSDESP---QQNC 349
NG CIG + +C+G DCG P +Q C
Sbjct: 1662 PNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGC 1694
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/297 (23%), Positives = 94/297 (31%), Gaps = 104/297 (35%)
Query: 200 YGRCILDIYHCDGDDDC-------GDWSDE-SDCSSHQPCRSGE---FMCDSGLCINA-- 246
Y C+ D CD DC ++DE + H RS E C+ G A
Sbjct: 1226 YEWCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACG 1285
Query: 247 --------------GWRCD-----------------GDADCDDQSD-------------- 261
GW C G A + S
Sbjct: 1286 PTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSV 1345
Query: 262 -ERNCTTSMCTAEQFRC----------------------HSGRCVRLSWRCDGEDDCADN 298
+++C C Q+ C +G CV W CD +DDC D
Sbjct: 1346 LQKDCGNCTCQEGQWHCGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDG 1405
Query: 299 SDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE----SPQ-------Q 347
SDEE C +P C Q C +G C+ LC+ +DCGD +DE PQ
Sbjct: 1406 SDEEGC---AAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADG 1462
Query: 348 NCRPRT----GEENC--NVNNGGCAQKCQMVRGAVQC---TCHTGYRLTEDGHTCQD 395
C P G +C + C + V G V C TC +L + C D
Sbjct: 1463 RCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPD 1519
Score = 59.3 bits (142), Expect = 3e-08
Identities = 34/119 (28%), Positives = 44/119 (36%), Gaps = 35/119 (29%)
Query: 106 PPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRK------------------ 147
PP +C + PC+ C+ CDG DC D SDE+ R
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 148 -----------------CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAP 189
CS + C G C++ CD DC+DGSDE+ C V AP
Sbjct: 2447 FMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAP 2505
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/125 (27%), Positives = 47/125 (37%), Gaps = 39/125 (31%)
Query: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC------------------------- 265
C G+ C+ C+ CDG DC D SDER+C
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 266 ---------TTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQ 316
+ ++C+ Q C SG C+ RCD DC D SDE+ C + C L
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVD-----CVLAP 2505
Query: 317 FLCWN 321
+ W+
Sbjct: 2506 WSVWS 2510
Score = 54.3 bits (129), Expect = 1e-06
Identities = 62/264 (23%), Positives = 80/264 (30%), Gaps = 53/264 (20%)
Query: 44 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRS---------WVCDGDN 94
C+ CDG DC D SDE+GC+L FH K + S W +G
Sbjct: 2246 CVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFH-STAKTLALSSAQPGQLLHWPREGLA 2304
Query: 95 DCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFR 154
+ E Q+ P E P G H + S + E R
Sbjct: 2305 ETEHWPPGQESPTSPTETR--PVSPGPASGVPHHGE--------SVQMVTTTPIPQMEAR 2354
Query: 155 CSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDD 214
A + + P P C + C C+ CDG +
Sbjct: 2355 TLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGRE 2414
Query: 215 DCGDWSDESDC---------------------------------SSHQPCRSGEFMCDSG 241
DC D SDE C +S C + C SG
Sbjct: 2415 DCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSG 2474
Query: 242 LCINAGWRCDGDADCDDQSDERNC 265
C++A RCD DC D SDE C
Sbjct: 2475 ECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 47.0 bits (110), Expect = 2e-04
Identities = 110/515 (21%), Positives = 153/515 (29%), Gaps = 124/515 (24%)
Query: 5 WGALLLGALLCAHGLASSP--ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSD 62
W A + ++ L P C S +C G C+ A+ +CD DC D SD
Sbjct: 2440 WAASTVPFMMPTMALPGLPASRALCSPSQLSC-----GSGECLSAERRCDLRPDCQDGSD 2494
Query: 63 EDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYC 122
EDGC+ +P C R + G + P C D F Q+ +
Sbjct: 2495 EDGCVDCVLAPWSVW---SSCSRSCGL--GLTFQRQELLRPPLPGGSCPRDRFRSQSCFV 2549
Query: 123 -------IRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWY--------C 167
++W G Q R C D + C C
Sbjct: 2550 QACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPC 2609
Query: 168 DGDTDCKDGS---DEENCPSAV--PAPPCNLE-------EFQCAYG-RC----ILDIYHC 210
G TDC+ G + C + P PP L+ C G RC +L C
Sbjct: 2610 SGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRC 2669
Query: 211 DGDDDCG-------DWSDES----DCSSHQPCRSGEFMCDSGLC-INAGWR-------CD 251
+C W S +C S C GE +C G C + GW CD
Sbjct: 2670 LPLSECPCLVGEELKWPGVSFLLGNC-SQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCD 2728
Query: 252 ---------------------GDADCDDQSDERNCTTSMCTAEQF--------RCHSGRC 282
G A C+ E ++C E F S C
Sbjct: 2729 RSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQSC 2788
Query: 283 VR----LSWR-----CDGEDDCADNSDEENCENTGSPQCALDQFL-CWNGRCIGQRKLCN 332
+ WR C D + D E P C + W
Sbjct: 2789 LAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDG 2848
Query: 333 GVNDCGDN-SDESPQQNCRPRTGEENCNVNNGGCAQKC---QMVRGAVQCTCHTGYRLTE 388
G+ G + S +P P + + N C +C + R A QC +
Sbjct: 2849 GIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQC--------HQ 2900
Query: 389 DGHTCQDV-------NECAEEGYCSQGCTNSEGAF 416
+G C + EC G+C+ GCT G F
Sbjct: 2901 EGGPCPRLCLTQGPGIECT--GFCAPGCTCPPGLF 2933
Score = 44.3 bits (103), Expect = 0.001
Identities = 17/37 (45%), Positives = 22/37 (59%)
Query: 69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
P C + C +G+C+ R CDG DCED SDE+ C
Sbjct: 2232 PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 43.9 bits (102), Expect = 0.002
Identities = 17/35 (48%), Positives = 20/35 (57%)
Query: 148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
C RC+ G C+ CDG DC+DGSDEE C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 42.4 bits (98), Expect = 0.004
Identities = 21/44 (47%), Positives = 22/44 (50%), Gaps = 4/44 (9%)
Query: 269 MCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC----ENTG 308
+C RC SG CV CDG DC D SDEE C E TG
Sbjct: 2233 LCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTG 2276
Score = 42.0 bits (97), Expect = 0.006
Identities = 20/43 (46%), Positives = 23/43 (53%)
Query: 183 PSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDC 225
P + PAP C +CA G C+L CDG DC D SDE C
Sbjct: 2226 PGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.1 bits (87), Expect = 0.083
Identities = 16/35 (45%), Positives = 18/35 (51%)
Query: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
C C SG C+ G CDG DC+D SDE C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.1 bits (87), Expect = 0.083
Identities = 90/438 (20%), Positives = 127/438 (28%), Gaps = 127/438 (28%)
Query: 39 LGECTCIPAQWQC--------DGDNDCGDHSDEDGCILPTCSPLDFHCD----------N 80
+G C C AQ D N+C + + C C P HC +
Sbjct: 4114 IGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPP-PTHCAWSHWSAWSPCS 4172
Query: 81 GKC--------IRRSWVCDGDNDC-EDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDG 131
C R S +C E+ S Q CP C C G R+L
Sbjct: 4173 HSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPP---LCLQGTRSRTL----- 4224
Query: 132 DNDCGDN-SDEQCDMRKCSDKEFRCSDGSC-IAEHW-----YCDGDTDCKDGSDEEN--C 182
GD+ +C C+ + C D C + E W + D C G+ C
Sbjct: 4225 ----GDSWLQGECQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRAC 4280
Query: 183 PSAVP---APPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
+A P +PPC + Q C G + W CS C
Sbjct: 4281 RAAAPHHRSPPCLGPDTQTRQ-------QPCPGLLEACSWGPWGPCSRS---------CG 4324
Query: 240 SGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSG----RCVRLSWRCDGEDDC 295
GL +G C + C ++ + C+SG CV SW C
Sbjct: 4325 PGLASRSG-----SCPCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRCSC 4379
Query: 296 A--------DNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
G+P LD G + C +++C ++S P +
Sbjct: 4380 RVLVQQRYRHQGPASRGARAGAPCTRLD----------GHFRPCL-ISNCSEDSCTPPFE 4428
Query: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
C C A C H ++L CQD+ C YC +
Sbjct: 4429 F--------------HACGSPC-----AGLCATHLSHQL------CQDLPPCQPGCYCPK 4463
Query: 408 GCTNSEGA------FQCW 419
G G CW
Sbjct: 4464 GLLEQAGGCIPPEECNCW 4481
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 203 bits (517), Expect = 1e-51
Identities = 102/247 (41%), Positives = 148/247 (59%), Gaps = 2/247 (0%)
Query: 1092 EGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVG 1151
EG VYW+D + I RA LDGS + +I T + D +AV+ + R +YWT TGT IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 1152 NLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLG 1211
L+ + K+LV +++D PRAI L+ EMG YW DWGEN +++R+ +D + VL+N +LG
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 1212 WPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDW 1270
WPNGL +D +L W DA T++IEA ++ R TL+ + H + TLL +IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 1271 QTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG 1330
Q SI R K + +++ LP LM ++AV+ + +G N RNGG + RP+
Sbjct: 182 QHHSIKRVHKVKANRDVII-DQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 1331 FSCACPT 1337
A P+
Sbjct: 241 PGLAAPS 247
Score = 196 bits (497), Expect = 2e-49
Identities = 101/247 (40%), Positives = 145/247 (58%), Gaps = 2/247 (0%)
Query: 1395 VDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454
++G VY+TD + IRRA L+GS +T+I + D +AV+WVAR+LYWT TG IE
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1455 SRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDL 1514
+ L+ + K+L++ +DEPRAIA+ P G +W DWG +I+RANLD E +VL+N L
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 1515 GWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIYWTD 1573
GWPNGL LD ++YW DA D+IE+ ++ RQ L+ + H F T +IYWT
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 1574 WQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARAS 1633
WQ SI+RV K N++ ++ + LM + V+ + GTN NGG +R +
Sbjct: 181 WQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPT 239
Query: 1634 DFVCACP 1640
A P
Sbjct: 240 QPGLAAP 246
Score = 190 bits (482), Expect = 1e-47
Identities = 90/244 (36%), Positives = 140/244 (57%), Gaps = 1/244 (0%)
Query: 784 DDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVA 843
+ HVYWTD I RA DG+G + +++T + P +A++WV LYWT GT+ IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 844 NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903
+ + +L+ E++D PR I + P G YW DWG +P+I+RA +D +V+++++L
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963
WPNGLA+D +LYW DA IE +D +KR+ L+ +LPH F TL G+ IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 964 QTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNP 1023
Q SI+ ++ +R+ + + L +LM + + + + P A NGG + P
Sbjct: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 1024 SGFS 1027
G +
Sbjct: 241 PGLA 244
Score = 172 bits (436), Expect = 3e-42
Identities = 84/227 (37%), Positives = 132/227 (58%), Gaps = 2/227 (0%)
Query: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541
V+W+D + I RA L+GS + +++T + P +AV+WV LYWT +GT IEV L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 542 GAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPN 601
K+L+ +++++PRAIALHP G YW DWG P I+ +++D R++ + L WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 602 GLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTK 661
GL +D ++YW DAK IE ++D + R+ ++ LPH F T+ D +YWT W
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 662 SINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGG 708
SI +K N+++I ++L M + ++ + G N D NGG
Sbjct: 185 SIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDK-VVGTNPHADRNGG 229
Score = 58.9 bits (141), Expect = 5e-08
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)
Query: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623
MEG +YWTD I + +DGSG + + +T + P+ + +++ R +YW IE
Sbjct: 1 MEGHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 624 RANLDGSHRKAVISQGLPHPFAITVFEDS--LYWTDWHTKSINSANKFTGKNQEIIRNKL 681
L+ + K ++S+ + P AI + + YW DW G+N EI R L
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDW------------GENPEIKRANL 107
Score = 36.6 bits (83), Expect = 0.24
Identities = 45/227 (19%), Positives = 82/227 (36%), Gaps = 54/227 (23%)
Query: 917 LYWADAGMKTIEFAGLDGSKRKVLIGSQL--PHPFGLTLYGERIYWTDWQTKSIQSADRL 974
+YW D + I A LDGS + LI +++ P + +YWT
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT------------- 51
Query: 975 TGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGI 1034
H + C SH L S + P I
Sbjct: 52 ---------------------HTGTEHIEVTCL---NSTSHKILVSEDMDE-----PRAI 82
Query: 1035 NLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGK 1094
L + G+ ++ + +I+ +LD ++ V +N ++ + +D QEGK
Sbjct: 83 ALHPE-----MGLTYWIDWGENPEIKRANLDRQ---ELRVLVNASLGWPNGLALDLQEGK 134
Query: 1095 VYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWT 1141
+YW D+ +I ++D ++ + ++ L +G +YWT
Sbjct: 135 LYWGDAKTDKIEAISVDETKRQTLLKDKLPHI--FRFTLLGDFIYWT 179
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 203 bits (517), Expect = 1e-51
Identities = 102/247 (41%), Positives = 148/247 (59%), Gaps = 2/247 (0%)
Query: 1092 EGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVG 1151
EG VYW+D + I RA LDGS + +I T + D +AV+ + R +YWT TGT IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 1152 NLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLG 1211
L+ + K+LV +++D PRAI L+ EMG YW DWGEN +++R+ +D + VL+N +LG
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 1212 WPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDW 1270
WPNGL +D +L W DA T++IEA ++ R TL+ + H + TLL +IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 1271 QTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG 1330
Q SI R K + +++ LP LM ++AV+ + +G N RNGG + RP+
Sbjct: 182 QHHSIKRVHKVKANRDVII-DQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 1331 FSCACPT 1337
A P+
Sbjct: 241 PGLAAPS 247
Score = 196 bits (497), Expect = 2e-49
Identities = 101/247 (40%), Positives = 145/247 (58%), Gaps = 2/247 (0%)
Query: 1395 VDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454
++G VY+TD + IRRA L+GS +T+I + D +AV+WVAR+LYWT TG IE
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1455 SRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDL 1514
+ L+ + K+L++ +DEPRAIA+ P G +W DWG +I+RANLD E +VL+N L
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 1515 GWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIYWTD 1573
GWPNGL LD ++YW DA D+IE+ ++ RQ L+ + H F T +IYWT
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 1574 WQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARAS 1633
WQ SI+RV K N++ ++ + LM + V+ + GTN NGG +R +
Sbjct: 181 WQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPT 239
Query: 1634 DFVCACP 1640
A P
Sbjct: 240 QPGLAAP 246
Score = 190 bits (482), Expect = 1e-47
Identities = 90/244 (36%), Positives = 140/244 (57%), Gaps = 1/244 (0%)
Query: 784 DDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVA 843
+ HVYWTD I RA DG+G + +++T + P +A++WV LYWT GT+ IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 844 NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903
+ + +L+ E++D PR I + P G YW DWG +P+I+RA +D +V+++++L
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963
WPNGLA+D +LYW DA IE +D +KR+ L+ +LPH F TL G+ IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 964 QTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNP 1023
Q SI+ ++ +R+ + + L +LM + + + + P A NGG + P
Sbjct: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 1024 SGFS 1027
G +
Sbjct: 241 PGLA 244
Score = 172 bits (436), Expect = 3e-42
Identities = 84/227 (37%), Positives = 132/227 (58%), Gaps = 2/227 (0%)
Query: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541
V+W+D + I RA L+GS + +++T + P +AV+WV LYWT +GT IEV L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 542 GAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPN 601
K+L+ +++++PRAIALHP G YW DWG P I+ +++D R++ + L WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 602 GLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTK 661
GL +D ++YW DAK IE ++D + R+ ++ LPH F T+ D +YWT W
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 662 SINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGG 708
SI +K N+++I ++L M + ++ + G N D NGG
Sbjct: 185 SIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDK-VVGTNPHADRNGG 229
Score = 58.9 bits (141), Expect = 5e-08
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)
Query: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623
MEG +YWTD I + +DGSG + + +T + P+ + +++ R +YW IE
Sbjct: 1 MEGHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 624 RANLDGSHRKAVISQGLPHPFAITVFEDS--LYWTDWHTKSINSANKFTGKNQEIIRNKL 681
L+ + K ++S+ + P AI + + YW DW G+N EI R L
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDW------------GENPEIKRANL 107
Score = 36.6 bits (83), Expect = 0.24
Identities = 45/227 (19%), Positives = 82/227 (36%), Gaps = 54/227 (23%)
Query: 917 LYWADAGMKTIEFAGLDGSKRKVLIGSQL--PHPFGLTLYGERIYWTDWQTKSIQSADRL 974
+YW D + I A LDGS + LI +++ P + +YWT
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT------------- 51
Query: 975 TGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGI 1034
H + C SH L S + P I
Sbjct: 52 ---------------------HTGTEHIEVTCL---NSTSHKILVSEDMDE-----PRAI 82
Query: 1035 NLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGK 1094
L + G+ ++ + +I+ +LD ++ V +N ++ + +D QEGK
Sbjct: 83 ALHPE-----MGLTYWIDWGENPEIKRANLDRQ---ELRVLVNASLGWPNGLALDLQEGK 134
Query: 1095 VYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWT 1141
+YW D+ +I ++D ++ + ++ L +G +YWT
Sbjct: 135 LYWGDAKTDKIEAISVDETKRQTLLKDKLPHI--FRFTLLGDFIYWT 179
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 203 bits (517), Expect = 1e-51
Identities = 111/298 (37%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 1352 PETYLLFSSRGSIRRISLD------TSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVF 1405
P T+LLF+ G I R+ L+ T +HVP +I L +D VD VY+TD+
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV---IIGLAFDCVDKMVYWTDIT 998
Query: 1406 LDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
I RA L+G T+I + L + +G+AVD + RN++WTD+ + IE ++LDG+ R+VL
Sbjct: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
Query: 1466 INNSLDEPRAIAVFPRKGYLFWTDWGH-IAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
L PR I +G L+WTDW KIE + +DG+ R++L+ DLG PNGLT D
Sbjct: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDA 1118
Query: 1525 DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 1584
+ ++ WVDA +R E + + R+ + + +PFA+T + +Y+TDW+ S+ +D
Sbjct: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDL 1178
Query: 1585 YSGRNKETVLANVE-GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPD 1641
+ + + + L I Q G N C VNNGGCTHLC A C CPD
Sbjct: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
Score = 198 bits (504), Expect = 4e-50
Identities = 170/570 (29%), Positives = 241/570 (42%), Gaps = 82/570 (14%)
Query: 225 CSSHQPCRSG---EFMCDSGLCINAGWRCDGDA--DCDDQSDERNCTTSMCTAEQ----F 275
C ++ CR G +F C+ + G+R DG D D+ S++ + S F
Sbjct: 679 CDTNAACRPGPRTQFTCECSI----GFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTF 734
Query: 276 RCHSGRCVRLSWRCDGEDDCADNSDEE----------NCENTGSPQCALDQFLCWNGRCI 325
RC CV ++ E C D+ NC+ QC + C+
Sbjct: 735 RCE---CVE-GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCL 790
Query: 326 ----GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQ---C 378
G + C V++C S P C G C G + V G V+ C
Sbjct: 791 PGFSGDGQACQDVDEC-QPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRC 849
Query: 379 TCHTGYRLTEDGHTCQD--------VNECAEEG-YCSQGCTNSEGAFQCWC--ETGYELR 427
+ L G T V EC G Y C S G CWC G E+
Sbjct: 850 QHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTG--YCWCVDRDGREVE 907
Query: 428 PDRRS------CKALGPEPV------------------LLFAN-----RIDIRQVLPHRS 458
R C + P+ LLFA R+ + ++
Sbjct: 908 GTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
Query: 459 EYTLLLN-NLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLA 517
E L+ + I L F ++V+W+D+T I RA+L+G ++ L SP G+A
Sbjct: 968 EAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIA 1027
Query: 518 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NT 576
VD + ++WTDS RIEVA LDG R+VL +L PR I + G +YWTDW +
Sbjct: 1028 VDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN 1087
Query: 577 PRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERAN-LDGSHRKAV 635
P+IE S MDG+ RRI+ L PNGLT D ++ WVDA + E N S RKA+
Sbjct: 1088 PKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL 1147
Query: 636 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQ 695
+GL +PFA+T + +LY+TDW S+ + + K + + + T +
Sbjct: 1148 --EGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQC 1205
Query: 696 PAGKNRCGDNNGGCTHLCLPSGQNYTCACP 725
P G N C NNGGCTHLCL + + TC CP
Sbjct: 1206 PQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
Score = 192 bits (489), Expect = 2e-48
Identities = 104/266 (39%), Positives = 153/266 (57%), Gaps = 8/266 (3%)
Query: 1076 INITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIG 1135
+++ K I + D + VYW+D T I RA+L G + II L + +G+AVD +G
Sbjct: 973 LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
Query: 1136 RKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG-ENAKLER 1194
R ++WTD+ +RIEV LDG+ R+VL +L +PR IV G +YWTDW +N K+E
Sbjct: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
Query: 1195 SGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQH 1254
S MDG++R +L+ ++LG PNGLT D SSQL W DA T R E + + +R + +Q+
Sbjct: 1093 SYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY 1152
Query: 1255 PYGLTLLDSYIYWTDWQTRSIHRAD----KGTGSNVILVRSNLPGLMDMQAVDRAQPLGF 1310
P+ +T +Y+TDW+ S+ D K T + ++ L G+ A+ + P G
Sbjct: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQC-PQGH 1209
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACP 1336
N C NGGC+HLCL P +C CP
Sbjct: 1210 NYCSVNNGGCTHLCLATPGSRTCRCP 1235
Score = 182 bits (462), Expect = 3e-45
Identities = 103/294 (35%), Positives = 154/294 (52%), Gaps = 10/294 (3%)
Query: 744 LLFARRMDIRRISFDTEDLSDDVIPL---ADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800
LLFA+ I R+ + + + + L +D D VYWTD++ +I RA
Sbjct: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
Query: 801 KWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 860
G ++ L SP G+A+D + ++WTD+ DRIEVA DG+ R VL +L
Sbjct: 1006 SLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
Query: 861 PRDIVVEPMGGYMYWTDWGA-SPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYW 919
PR IV + + G +YWTDW +PKIE + MD + R++++ +L PNGL D S +L W
Sbjct: 1066 PRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCW 1125
Query: 920 ADAGMKTIEFAG-LDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLD 978
DAG E S+RK L G L +PF +T YG+ +Y+TDW+ S+ + D +
Sbjct: 1126 VDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE 1183
Query: 979 RETLQENLE-NLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCP 1031
+ Q + + L I + P C++ NGGC+HLCL +P +C CP
Sbjct: 1184 TDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCRCP 1235
Score = 49.3 bits (116), Expect = 4e-05
Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 12/110 (10%)
Query: 330 LCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTED 389
L N + + S ++ Q C G C+ N C R C C G+R D
Sbjct: 653 LSNSIGPVREGSPDALQNPCY--IGTHGCDTN-AACRPG---PRTQFTCECSIGFR--GD 704
Query: 390 GHTCQDVNECAEE-GYCSQG--CTNSEGAFQCWCETGYELRPDRRSCKAL 436
G TC D++EC+E+ C C N G F+C C GY+ D +C A+
Sbjct: 705 GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTCVAV 753
Score = 48.1 bits (113), Expect = 8e-05
Identities = 50/200 (25%), Positives = 69/200 (34%), Gaps = 41/200 (20%)
Query: 230 PCRSGEFMCDSGLCINAGWRCDGDADCDD--QSDERNCTTSMCTAEQFRCHSGRCVRLSW 287
PC G CD+ G R +C + D R C +EQ
Sbjct: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV---------- 720
Query: 288 RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
C C ++ CE C G C V D+ P
Sbjct: 721 -CGSHTICNNHPGTFRCE-------------CVEGYQFSDEGTCVAV------VDQRPIN 760
Query: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
C TG NC++ AQ + C+C G+ + DG CQDV+EC + C
Sbjct: 761 YCE--TGLHNCDIPQR--AQCIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-QPSRCHP 813
Query: 408 G--CTNSEGAFQCWCETGYE 425
C N+ G+F C C+ GY+
Sbjct: 814 DAFCYNTPGSFTCQCKPGYQ 833
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 177 bits (449), Expect = 9e-44
Identities = 143/454 (31%), Positives = 193/454 (42%), Gaps = 95/454 (20%)
Query: 27 CGRS-HFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIR 85
CGR +F CA CIP + QC+G NDC D SDE C CS FHC GKC+
Sbjct: 269 CGRGENFLCASGI-----CIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLN 320
Query: 86 RSWVCDGDNDCEDDSDEQDCPPRECE-EDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QC 143
S VCDG +DC D SDEQ+C +C E C +G CI W CDGD+DC D SDE C
Sbjct: 321 YSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Query: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRC 203
S C +G CI + CDGD DCKDGSDEENC +V C + +C Y C
Sbjct: 378 SCH--SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENC--SVIQTSCQEGDQRCLYNPC 433
Query: 204 ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA-----------GWRCDG 252
+ C G C + ++CS +P LC+N G R
Sbjct: 434 ---LDSCGGSSLCDPNNSLNNCSQCEP-------ITLELCMNLPYNSTSYPNYFGHRTQK 483
Query: 253 DADCDDQSD------ERNC--------------------------TTSMCTAEQFRCHSG 280
+A +S + NC ++C + RC S
Sbjct: 484 EASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESV 543
Query: 281 -RCVRLSWRCDGEDDCA----DNSDEENC--ENTGSPQCALDQFLCWNGRCIGQRKLCNG 333
V L W D DC+ +NSD + C + +C+ F C +G+C+ + C+G
Sbjct: 544 LGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDG 601
Query: 334 VNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
DC D+SDE +NC + + +N C + + G C Y ++ C
Sbjct: 602 QADCDDDSDE---ENCGCKERDLWECPSNKQCLKHTVICDGFPDC---PDYMDEKNCSFC 655
Query: 394 QDVN-ECAEEGYCSQ--------GCTNSEGAFQC 418
QD ECA S+ C++S + C
Sbjct: 656 QDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 155 bits (391), Expect = 5e-37
Identities = 87/213 (40%), Positives = 111/213 (52%), Gaps = 18/213 (8%)
Query: 57 CGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP 116
C E+G L +F C +G CI C+G NDC+D SDE C C E+ F
Sbjct: 256 CFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFH 312
Query: 117 CQNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175
C G C+ CDG +DCGD SDEQ CD + E RC DG CIA W CDGD DC D
Sbjct: 313 CHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT--EHRCGDGRCIAMEWVCDGDHDCVD 370
Query: 176 GSDEENCPSAVPAPPCNLEEF-QCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQ-PCRS 233
SDE NC C+ + +C G+CI + CDGD+DC D SDE +CS Q C+
Sbjct: 371 KSDEVNC-------SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
Query: 234 GEFMCDSGLCINAGWRCDGDADCDDQSDERNCT 266
G+ C C+++ C G + CD + NC+
Sbjct: 424 GDQRCLYNPCLDS---CGGSSLCDPNNSLNNCS 453
Score = 121 bits (303), Expect = 7e-27
Identities = 102/352 (28%), Positives = 138/352 (39%), Gaps = 74/352 (21%)
Query: 15 CAHGLASSPECACGRSH----------FTCAVSALGECT---CIPAQWQCDGDNDCGDHS 61
C G + E C H +C L EC CIP+ +QCDGD DC D S
Sbjct: 350 CGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGS 409
Query: 62 DEDGC--ILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRE---------- 109
DE+ C I +C D C C+ C G + C+ ++ +C E
Sbjct: 410 DEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNL 466
Query: 110 ----------------------CEEDEFPC---QNGYCIRSLWHCD-GDNDCGDNSDEQC 143
E FP N Y + C C N+ E
Sbjct: 467 PYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHI 526
Query: 144 DMRK--CSDKEFRC-SDGSCIAEHWYCDGDTDC----KDGSDEENC--PSAVPAPPCNLE 194
+ C + RC S + W DTDC ++ SD + C P C+
Sbjct: 527 PPCRALCEHSKERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEY-VEECSPS 583
Query: 195 EFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGE-FMCDSG-LCINAGWRCDG 252
F+C G+C+L CDG DC D SDE +C C+ + + C S C+ CDG
Sbjct: 584 HFKCRSGQCVLASRRCDGQADCDDDSDEENCG----CKERDLWECPSNKQCLKHTVICDG 639
Query: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
DC D DE+NC S C ++ C + CV CDGE DC+D+SDE +C
Sbjct: 640 FPDCPDYMDEKNC--SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 102 bits (254), Expect = 4e-21
Identities = 64/184 (34%), Positives = 88/184 (47%), Gaps = 22/184 (11%)
Query: 96 CEDDSDEQDCPPRE-CEEDEFPCQNGYCIRSLWHCDGDNDCG----DNSDEQ-CDM---- 145
C+ ++ E P R CE + C++ I L + D DC +NSD Q C M
Sbjct: 518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPE-DTDCSQFPEENSDNQTCLMPDEY 576
Query: 146 -RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGR-C 203
+CS F+C G C+ CDG DC D SDEENC + ++C + C
Sbjct: 577 VEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK------ERDLWECPSNKQC 630
Query: 204 ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDER 263
+ CDG DC D+ DE +CS C+ E C + C++ CDG+ADC D SDE
Sbjct: 631 LKHTVICDGFPDCPDYMDEKNCSF---CQDDELECANHACVSRDLWCDGEADCSDSSDEW 687
Query: 264 NCTT 267
+C T
Sbjct: 688 DCVT 691
Score = 31.6 bits (70), Expect = 7.7
Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 5/41 (12%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCI 67
C CA A C+ CDG+ DC D SDE C+
Sbjct: 655 CQDDELECANHA-----CVSRDLWCDGEADCSDSSDEWDCV 690
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 174 bits (441), Expect = 7e-43
Identities = 104/270 (38%), Positives = 155/270 (57%), Gaps = 6/270 (2%)
Query: 1350 PSPETYLLFSSRGSIRRISLD-TSDHTDVHVPVPELNN--VISLDYDSVDGKVYYTDVFL 1406
PS T+LL++ I + L+ T D + L+ ++ +DYD + VY+TDV
Sbjct: 1104 PSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAG 1163
Query: 1407 DVIRRADLN-GSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
I RA L G+ ET++ GL + +GLA+D + R +YWTD+ + IE++ LDGS RKVL
Sbjct: 1164 RTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVL 1223
Query: 1466 INNSLDEPRAIAVFPRKGYLFWTDWGHIA-KIERANLDGSERKVLINTDLGWPNGLTLDY 1524
L PRAIAV P +G L+WTDW A KIE ++LDG R++LINTD+G PNGLT D
Sbjct: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
Query: 1525 DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 1584
++ + W DA ++E +G R+V+ +++ +PF++ Y TDW+ + V+K
Sbjct: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
Query: 1585 YSGRNKETVLANVEG-LMDIIVVSPQRQTG 1613
+SG+ + L L I V P TG
Sbjct: 1344 HSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1373
Score = 173 bits (438), Expect = 2e-42
Identities = 179/615 (29%), Positives = 250/615 (40%), Gaps = 72/615 (11%)
Query: 111 EEDEFPCQNGYCIRSLWHCDGDNDC--GDNSDEQC--------DMRKCSDKE------FR 154
+ED P C CD C G D C D R C D+ R
Sbjct: 752 KEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHR 811
Query: 155 CSDGS-CI--AEHWYCDGDTDCKDGSDEENCPSAVP-APPCNLEEFQCAYGRCILDIYHC 210
C S CI + C+ + + D C P A PC CA ++H
Sbjct: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
Query: 211 DGDDDC----GDWSDESDCSSHQPCRSGEFMCD-SGLCINA----GWRCDGDADCDDQSD 261
C G D C+ C E C + C N RC D
Sbjct: 872 GSTFSCACLPGYAGDGHQCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQC 929
Query: 262 ERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCW- 320
+ T+S+ EQ + H+ + + G DE+ N QC CW
Sbjct: 930 IPDSTSSLTPCEQQQRHA----QAQYAYPGARFHIPQCDEQG--NFLPLQCHGSTGFCWC 983
Query: 321 ---NGRCIGQRKLCNGVND--CGDNSDESPQQNCRPRT----GEENCNVNNGGCAQKCQM 371
+G + + G CG SP+ RP T EN + GG + Q
Sbjct: 984 VDPDGHEVPGTQTPPGSTPPHCGP----SPEPTQRPPTICERWRENLLEHYGGTPRDDQY 1039
Query: 372 VRGAVQCTCHTGYRLTEDGHTCQDVNECAE-EGYCSQGCTNSEGAFQCWCETGYE--LRP 428
V QC G+ + H D C + +G QG + G T +RP
Sbjct: 1040 VP---QCD-DLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRP 1095
Query: 429 DRRSCKALGPEPVLLFANRIDIRQV---------LPHRSEYTLLLNNLENAIALDFHHRR 479
R + P V F +Q+ L + TLL + + +D+ R
Sbjct: 1096 TPRP--DVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRE 1153
Query: 480 ELVFWSDVTLDRILRANLN-GSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVA 538
+V+W+DV I RA L G+ E +V++GL SP GLA+D + +YWTDS +IE A
Sbjct: 1154 RMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 1213
Query: 539 NLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGRRIIADTHL 597
LDG+ RKVL + +L PRAIA+ P+ G +YWTDW P+IE SS+DG RRI+ +T +
Sbjct: 1214 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDI 1273
Query: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTD 657
PNGLT D + + W DA +E DG+ R+ VI L +PF+I + D Y TD
Sbjct: 1274 GLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHTD 1332
Query: 658 WHTKSINSANKFTGK 672
W + S NK +G+
Sbjct: 1333 WRRDGVVSVNKHSGQ 1347
Score = 172 bits (436), Expect = 3e-42
Identities = 108/291 (37%), Positives = 157/291 (53%), Gaps = 12/291 (4%)
Query: 708 GCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVI 767
G T C+P T A P S+ FLL+ + I + + L D
Sbjct: 1079 GTTPACIP-----TVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAA 1133
Query: 768 P-LADVRSA--VALDWDSRDDHVYWTDVSTDTISRAKWD-GTGQEVVVDTSLESPAGLAI 823
L + + V +D+D R+ VYWTDV+ TISRA + G E +V++ L SP GLAI
Sbjct: 1134 KTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAI 1193
Query: 824 DWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWG-ASP 882
D + +YWTD+ D+IE A DGS R VL + +L PR I V+P+ G +YWTDW +P
Sbjct: 1194 DHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
Query: 883 KIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIG 942
KIE + +D R+++I++++ PNGL D S+ L WADAG K +E DG+ R+V I
Sbjct: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRV-IQ 1312
Query: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTG-LDRETLQENLENLMDI 992
+ L +PF + Y + Y TDW+ + S ++ +G E L E +L I
Sbjct: 1313 NNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGI 1363
Score = 164 bits (415), Expect = 8e-40
Identities = 88/243 (36%), Positives = 142/243 (58%), Gaps = 4/243 (1%)
Query: 1045 PGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDP--QEGKVYWSDSTL 1102
P + +FL++ + I + L+ +++ +I +G+D +E VYW+D
Sbjct: 1104 PSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAG 1163
Query: 1103 HRISRANLD-GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVL 1161
ISRA L+ G++ E I+ +GL + +GLA+D I R +YWTD+ ++IE LDGS RKVL
Sbjct: 1164 RTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVL 1223
Query: 1162 VWQNLDSPRAIVLYHEMGFMYWTDWGENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDK 1220
+ +L +PRAI + G +YWTDW A K+E S +DG +R +LIN ++G PNGLT D
Sbjct: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
Query: 1221 ASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK 1280
S L WADA T+++E +G R + + +++P+ + + Y TDW+ + +K
Sbjct: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
Query: 1281 GTG 1283
+G
Sbjct: 1344 HSG 1346
Score = 70.9 bits (172), Expect = 1e-11
Identities = 59/211 (27%), Positives = 82/211 (38%), Gaps = 40/211 (18%)
Query: 217 GDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDD--QSDERNCTTSMCTAEQ 274
G ++SD + PC G MCD+ + G D +C Q D RNC ++
Sbjct: 749 GPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNC------VDE 802
Query: 275 FRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
C +G RC C + CE + A D+ C +
Sbjct: 803 NECATG-----FHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC--------ILITPPA 849
Query: 335 NDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQ 394
N C D S C P G+ C V++GG C C GY DGH C
Sbjct: 850 NPCEDGS-----HTCAP-AGQARC-VHHGG---------STFSCACLPGY--AGDGHQCT 891
Query: 395 DVNECAEEG-YCSQGCTNSEGAFQCWCETGY 424
DV+EC+E + + C N+ G+F C C+ GY
Sbjct: 892 DVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
Score = 53.1 bits (126), Expect = 2e-06
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 332 NGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGA-VQCTCHTGYRLTEDG 390
N + ++SD +P C G C+ +C G C C +GY+ DG
Sbjct: 746 NQIGPVKEDSDPTPGNPCYD--GSHMCDTT-----ARCHPGTGVDYTCECASGYQ--GDG 796
Query: 391 HTCQDVNECAEEGYCSQG----CTNSEGAFQCWCETGYELRPDRRSCKALGP 438
C D NECA G+ G C N G+++C C +GYE DR +C + P
Sbjct: 797 RNCVDENECAT-GFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITP 847
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 141 bits (356), Expect = 5e-33
Identities = 78/207 (37%), Positives = 93/207 (44%), Gaps = 48/207 (23%)
Query: 146 RKCSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEENC---------------------- 182
R C++ EF C S C+A + CD DC+D SDE NC
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 183 --------------------PSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE 222
P +V PC +E C G CI Y CDG +DC D SDE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 223 SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTT----SMCTAEQFRCH 278
DC PC EF C +G C WRCDGD DC+D++DE NC T +C QFRC
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 279 S-GRCVRLSWRCDGEDDCADNSDEENC 304
S C+ S+ CD E DC D SDE C
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 138 bits (347), Expect = 6e-32
Identities = 84/233 (36%), Positives = 106/233 (45%), Gaps = 60/233 (25%)
Query: 26 ACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC------ILPT--------- 70
AC + F C + EC + +++CD DC D SDE C I PT
Sbjct: 198 ACTEAEFAC--HSYNECVAL--EYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTS 253
Query: 71 -------------------------------CSPLDFHCDNGKCIRRSWVCDGDNDCEDD 99
C P + C NG CI R ++CDG DCED
Sbjct: 254 LPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313
Query: 100 SDEQDC-PPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRK----CSDKEF 153
SDE DC PP CE +EFPC NG+C LW CDGD DC D +DE C ++ C +F
Sbjct: 314 SDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQF 373
Query: 154 RC-SDGSCIAEHWYCDGDTDCKDGSDEENC-PSAVPAPPCNLEEFQCAYGRCI 204
RC S CI ++CD ++DC D SDE C P V PP E Q + G+ +
Sbjct: 374 RCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPP--RESIQASRGQTV 424
Score = 125 bits (315), Expect = 3e-28
Identities = 72/211 (34%), Positives = 96/211 (45%), Gaps = 55/211 (26%)
Query: 107 PRECEEDEFPCQN-GYCIRSLWHCDGDNDCGDNSDE-QCD-------------------- 144
PR C E EF C + C+ + CD DC D SDE C+
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 145 -------MRK-------------------CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
MR+ C +E C +G CI + CDG DC+DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 179 EENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP---CRSGE 235
E +C P PPC EF C G C L ++ CDGD DC D +DE++C + +P C +
Sbjct: 316 ELDCG---PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372
Query: 236 FMC-DSGLCINAGWRCDGDADCDDQSDERNC 265
F C + +CI A + CD ++DC D+SDE C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 103 bits (256), Expect = 2e-21
Identities = 53/124 (42%), Positives = 64/124 (51%), Gaps = 18/124 (14%)
Query: 24 ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC-ILPTCSPLDFHCDNGK 82
E AC H CIP + CDG DC D SDE C P C P +F C NG
Sbjct: 289 EAACRNGH------------CIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGH 336
Query: 83 CIRRSWVCDGDNDCEDDSDEQDCPPRECEE----DEFPC-QNGYCIRSLWHCDGDNDCGD 137
C + W CDGD DCED +DE +CP + EE +F C CI + +HCD ++DC D
Sbjct: 337 CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPD 396
Query: 138 NSDE 141
SDE
Sbjct: 397 RSDE 400
Score = 101 bits (252), Expect = 6e-21
Identities = 66/203 (32%), Positives = 82/203 (40%), Gaps = 51/203 (25%)
Query: 191 CNLEEFQC-AYGRCILDIYHCDGDDDCGDWSDESDCS----------------------- 226
C EF C +Y C+ Y CD DC D SDE +C
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 227 ----------SHQP------------CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERN 264
+H P C E C +G CI + CDG DC+D SDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 265 C-TTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQ--CALDQFLCWN 321
C C +F C +G C WRCDG+ DC D +DE NC T P+ C QF C +
Sbjct: 319 CGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP-TKRPEEVCGPTQFRCVS 377
Query: 322 -GRCIGQRKLCNGVNDCGDNSDE 343
CI C+ +DC D SDE
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDE 400
Score = 85.5 bits (210), Expect = 5e-16
Identities = 55/195 (28%), Positives = 75/195 (38%), Gaps = 52/195 (26%)
Query: 231 CRSGEFMCDS-GLCINAGWRCDGDADCDDQSDERNC----------------TTSM---- 269
C EF C S C+ +RCD DC D SDE NC TTS+
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 270 --------------------------CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEEN 303
C ++ C +G C+ + CDG++DC D SDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 304 CENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNG 363
C P C ++F C NG C + C+G DC D +DE+ NC + EE C
Sbjct: 319 CGPP--PPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEA---NCPTKRPEEVCGPTQF 373
Query: 364 GCAQKCQMVRGAVQC 378
C + + C
Sbjct: 374 RCVSTNMCIPASFHC 388
Score = 68.9 bits (167), Expect = 4e-11
Identities = 52/160 (32%), Positives = 58/160 (36%), Gaps = 51/160 (31%)
Query: 270 CTAEQFRCHS-GRCVRLSWRCDGEDDCADNSDEENCEN---------------------- 306
CT +F CHS CV L +RCD DC D SDE NCE
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 307 ----------TGSPQ-----------CALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE-- 343
T +PQ C + C NG CI + LC+G DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 344 -SPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHT 382
P C P E C NG CA K G C T
Sbjct: 319 CGPPPPCEP--NEFPC--GNGHCALKLWRCDGDFDCEDRT 354
Score = 47.8 bits (112), Expect = 1e-04
Identities = 21/47 (44%), Positives = 28/47 (59%), Gaps = 4/47 (8%)
Query: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILP 69
PE CG + F C + + CIPA + CD ++DC D SDE GC+ P
Sbjct: 364 PEEVCGPTQFRCVSTNM----CIPASFHCDEESDCPDRSDEFGCMPP 406
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 139 bits (349), Expect = 3e-32
Identities = 70/156 (44%), Positives = 88/156 (56%), Gaps = 10/156 (6%)
Query: 73 PLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEE-DEFPCQNGYCIRSLWHCDG 131
P F C G+CIR+ CDG DC D SDE +C C+ +F C+N +C W CD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDS 510
Query: 132 DNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPP 190
NDCGDNSDEQ C C + FRCS+G C+++ C+G DC DGSDE +CP V
Sbjct: 511 VNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPK-VNVVT 566
Query: 191 CNLEEFQCAYGRCI-LDIYHCDGDDDCGDWSDESDC 225
C ++C G C+ CDG +DC D SDE DC
Sbjct: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 131 bits (329), Expect = 7e-30
Identities = 77/233 (33%), Positives = 107/233 (45%), Gaps = 37/233 (15%)
Query: 120 GYCIRSLWHCDGDNDCGDNSD-------EQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTD 172
G C + +G+ CG+ S + +R SD+ + +D +AE+ D
Sbjct: 395 GTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSY--TDTGFLAEYLSYDSSDP 452
Query: 173 CKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCR 232
C +F C GRCI CDG DC D SDE +CS C
Sbjct: 453 CPG-------------------QFTCRTGRCIRKELRCDGWADCTDHSDELNCS----CD 489
Query: 233 SG-EFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDG 291
+G +F C + C W CD DC D SDE+ C+ C A+ FRC +G+C+ S +C+G
Sbjct: 490 AGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCS---CPAQTFRCSNGKCLSKSQQCNG 546
Query: 292 EDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ-RKLCNGVNDCGDNSDE 343
+DDC D SDE +C C + C NG C+ + C+G DC D SDE
Sbjct: 547 KDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 122 bits (306), Expect = 3e-27
Identities = 65/157 (41%), Positives = 85/157 (54%), Gaps = 17/157 (10%)
Query: 32 FTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTC-SPLDFHCDNGKCIRRSWVC 90
FTC CI + +CDG DC DHSDE C +C + F C N C WVC
Sbjct: 457 FTCRTGR-----CIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVC 508
Query: 91 DGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE----QCDMR 146
D NDC D+SDEQ C C F C NG C+ C+G +DCGD SDE + ++
Sbjct: 509 DSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 147 KCSDKEFRCSDGSCIAE-HWYCDGDTDCKDGSDEENC 182
C+ +RC +G C+++ + CDG DC DGSDE++C
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 118 bits (295), Expect = 6e-26
Identities = 64/172 (37%), Positives = 85/172 (49%), Gaps = 14/172 (8%)
Query: 208 YHCDGD-DDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCT 266
+H D D G ++ S PC G+F C +G CI RCDG ADC D SDE NC+
Sbjct: 429 FHSDQSYTDTGFLAEYLSYDSSDPC-PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS 487
Query: 267 TSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIG 326
QF C + C L W CD +DC DNSDE+ C C F C NG+C+
Sbjct: 488 CD--AGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCS------CPAQTFRCSNGKCLS 539
Query: 327 QRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQC 378
+ + CNG +DCGD SDE+ +C P+ C + C + +G +C
Sbjct: 540 KSQQCNGKDDCGDGSDEA---SC-PKVNVVTCTKHTYRCLNGLCLSKGNPEC 587
Score = 117 bits (292), Expect = 1e-25
Identities = 61/159 (38%), Positives = 85/159 (53%), Gaps = 16/159 (10%)
Query: 152 EFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNL-EEFQCAYGRCILDIYHC 210
+F C G CI + CDG DC D SDE NC C+ +F C C + C
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCS-------CDAGHQFTCKNKFCKPLFWVC 508
Query: 211 DGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC---TT 267
D +DCGD SDE CS C + F C +G C++ +C+G DC D SDE +C
Sbjct: 509 DSVNDCGDNSDEQGCS----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNV 564
Query: 268 SMCTAEQFRCHSGRCV-RLSWRCDGEDDCADNSDEENCE 305
CT +RC +G C+ + + CDG++DC+D SDE++C+
Sbjct: 565 VTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 107 bits (266), Expect = 1e-22
Identities = 55/126 (43%), Positives = 67/126 (53%), Gaps = 14/126 (11%)
Query: 25 CACGRSH-FTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKC 83
C+C H FTC C P W CD NDCGD+SDE GC +C F C NGKC
Sbjct: 486 CSCDAGHQFTCKNKF-----CKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKC 537
Query: 84 IRRSWVCDGDNDCEDDSDEQDCPPRE---CEEDEFPCQNGYCI-RSLWHCDGDNDCGDNS 139
+ +S C+G +DC D SDE CP C + + C NG C+ + CDG DC D S
Sbjct: 538 LSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGS 597
Query: 140 DEQ-CD 144
DE+ CD
Sbjct: 598 DEKDCD 603
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 117 bits (293), Expect = 1e-25
Identities = 102/411 (24%), Positives = 155/411 (37%), Gaps = 75/411 (18%)
Query: 74 LDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP--CQNGYCIRSL--WHC 129
LD C G + C+ N+CE FP C NG C+ S +HC
Sbjct: 937 LDTACPRGLARIKGVTCEDVNECE----------------VFPGVCPNGRCVNSKGSFHC 980
Query: 130 --------DGDND-CGDNSDEQCDMRKCSDK-------EFRCSDGSC-IAEHWYCDGDTD 172
DG C D EQC ++ D+ +FR C + W + +
Sbjct: 981 ECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEEC 1040
Query: 173 CKDGSDEEN--CPSAV----------------PAPPCNLEEFQCAYGRC--ILDIYHCDG 212
K G+ E CP C C YG+C + + C
Sbjct: 1041 PKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRC 1100
Query: 213 DDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDE-----RNCTT 267
+ +E +C+ CR +C SG+C+N + +C + + +NC
Sbjct: 1101 NSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFE--CECFEGYESGFMMMKNCMD 1158
Query: 268 -SMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRC 324
C C G CV S++CD + E+C + +C+L LC NG+C
Sbjct: 1159 IDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDIN--ECSLSDNLCRNGKC 1216
Query: 325 IGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGY 384
+ G C N + + T + C + NGGC +C G+ +C+C GY
Sbjct: 1217 VNMI----GTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGY 1272
Query: 385 RLTEDGHTCQDVNECAEE-GYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
L DG +C D++EC C G CTN G ++C C G+ D ++C
Sbjct: 1273 ALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Score = 105 bits (263), Expect = 3e-22
Identities = 109/448 (24%), Positives = 159/448 (35%), Gaps = 79/448 (17%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCI-LPTCSPLDFHCDNGKCIR 85
C R+ C G C +QCD + C+ + CS D C NGKC+
Sbjct: 1162 CERNPLLCRG---GTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVN 1218
Query: 86 RSWVCDGDNDCEDDSDEQDCPPRE-CEE-DEFPCQNGYCIRSLWHCDGDNDCGDNSDEQC 143
G C + Q P R+ C + DE NG C + +G +C
Sbjct: 1219 MI----GTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS------- 1267
Query: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP------------------SA 185
CS+ DG A+ C+ + D DG N P +
Sbjct: 1268 ----CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Query: 186 VPAPPCNLEEFQCAYGRCILD----IYHCD-------GDDDCGDWSD----ESDCSSHQP 230
+ C+L C +G C I HC G C D + +C H
Sbjct: 1324 IDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHAS 1383
Query: 231 CRS--GEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRL--S 286
C + G F C GW +G C D DE + T C+ + +CV S
Sbjct: 1384 CLNIPGSFKCSC----REGWIGNG-IKCIDL-DECSNGTHQCSI------NAQCVNTPGS 1431
Query: 287 WRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQ 346
+RC C++ + + +CA + LC NG+C+ G C +P
Sbjct: 1432 YRCA----CSEGFTGDGFTCSDVDECAENINLCENGQCLN----VPGAYRCECEMGFTPA 1483
Query: 347 QNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCS 406
+ R + C+ N C + G C C GY L G C D++ECA+ C
Sbjct: 1484 SDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
Query: 407 QG-CTNSEGAFQCWCETGYELRPDRRSC 433
G C N+ G ++C C ++L P C
Sbjct: 1544 NGLCVNTPGRYECNCPPDFQLNPTGVGC 1571
Score = 103 bits (258), Expect = 1e-21
Identities = 110/438 (25%), Positives = 163/438 (37%), Gaps = 80/438 (18%)
Query: 40 GECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLD------FHCDNGKCIRR--SWVCD 91
G C P ++C+ C + + ++ C +D C G C+ S+ CD
Sbjct: 1129 GICVNTPGSFECE----CFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCD 1184
Query: 92 GDNDCEDDSDEQDCPP-RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQC--DMRKC 148
E +DC EC + C+NG C+ + G C N Q D + C
Sbjct: 1185 CPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMI----GTYQCSCNPGYQATPDRQGC 1240
Query: 149 SDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIY 208
+D + C+ + CD +GS E +C P GR DI
Sbjct: 1241 TDID------ECMIMNGGCDTQCTNSEGSYECSCSEGYALMPD---------GRSCADID 1285
Query: 209 HCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWR-CDGDADCDDQSDERNCTT 267
C+ + D D ++ C +C G + + C +CD S+ C
Sbjct: 1286 ECENNPDICDGGQCTNIPGEYRC-----LCYDGFMASMDMKTCIDVNECDLNSNI--CMF 1338
Query: 268 SMC--TAEQFRCHS--GRCVRLSWR-CDGEDDC---ADNSD-EENCENT-GSPQCALDQF 317
C T F CH G V+ C D+C A N D +C N GS +C+ +
Sbjct: 1339 GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
Query: 318 LCWNG-RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNG------------G 364
NG +CI + NG + C N+ C G C + G
Sbjct: 1399 WIGNGIKCIDLDECSNGTHQCSINAQ------CVNTPGSYRCACSEGFTGDGFTCSDVDE 1452
Query: 365 CAQ--------KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGA 415
CA+ +C V GA +C C G+ D +CQD++EC+ + C G C N G
Sbjct: 1453 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGM 1512
Query: 416 FQCWCETGYELRPDRRSC 433
F C C+ GYEL +C
Sbjct: 1513 FHCICDDGYELDRTGGNC 1530
Score = 88.2 bits (217), Expect = 7e-17
Identities = 99/399 (24%), Positives = 149/399 (37%), Gaps = 70/399 (17%)
Query: 78 CDNGKCIRR--SWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRS--LWHCDGDN 133
C NG+CI S+ C+ + + D++ EC + PC NG C+ + ++C
Sbjct: 505 CLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN--PCTNGDCVNTPGSYYCKCHA 562
Query: 134 DCGDNSDEQC--DMRKCSDKEFRCSDGSCIAEH--WYCDGDTDCKDGSDEENCPSAVPAP 189
+Q D+ +C C +G C+ + C + + +D +NC
Sbjct: 563 GFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECT 622
Query: 190 PCNLEEFQCAYGRCILDIYHCDGDDDC-----------GDWSDESDCSSHQPCRSGEFMC 238
N+ C G CI + DG C G + C+ C++ +C
Sbjct: 623 TTNM----CLNGMCINE----DGSFKCICKPGFVLAPNGRY-----CTDVDECQTPG-IC 668
Query: 239 DSGLCINA--GWRCDGDADCDDQSDERNCT-TSMCTAEQFRCHSGRCVRLSWRCDGEDDC 295
+G CIN+ +RCD D R C T M + G CVR + +C
Sbjct: 669 MNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSEC 728
Query: 296 -----------------ADNSDEEN----------CENTGSPQCALDQFLCWNGRCIGQR 328
A NS E + + +CALD +C NG C R
Sbjct: 729 CCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLR 788
Query: 329 KLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQK-CQMVRGAVQCTCHTGYRLT 387
G C NS P + R + C VN C C+ G+ CTC GY
Sbjct: 789 ----GSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFR 844
Query: 388 EDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYEL 426
+ TC+D+NEC + C N+ G+F C C G +L
Sbjct: 845 TETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKL 883
Score = 86.7 bits (213), Expect = 2e-16
Identities = 118/482 (24%), Positives = 169/482 (35%), Gaps = 95/482 (19%)
Query: 36 VSALGECTCIPAQWQC---------DGDNDCGDHSDEDGCILP----TCS-PLDFHCDNG 81
+ G CT P +QC D C D + + C CS P F+
Sbjct: 2066 ICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFD-TRQSFCFTNFENGKCSVPKAFNTTKA 2124
Query: 82 KCIRRSWVCDGDND-CE-----DDSDEQDCPP----------------RECEEDEFPCQN 119
KC +G D CE D+ QD P EC E C N
Sbjct: 2125 KCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSN 2184
Query: 120 GYCIRSLWHCDGDNDCGDNSDEQCDMR--KCSDKEFRCSDGSCIAEHWYCDGDTDCKD-- 175
G CI + DG C D +C D + CS G+ G+ C +
Sbjct: 2185 GQCINT----DGSFRCECPMGYNLDYTGVRCVDTD-ECSIGNPC-------GNGTCTNVI 2232
Query: 176 GSDEENCPSAV-PAPPCNLEEFQ--------CAYGRCI--LDIYHCDGDDDCGDWSDESD 224
GS E NC P P N E+ CA+ RC+ Y C D+
Sbjct: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKM 2291
Query: 225 CSSHQPCRSGEFMCDSG--LCIN--AGWRCDGDADCDDQSDERNCTT-SMCTAEQFRCHS 279
C C G C+S +C N + C + D C + C + C +
Sbjct: 2292 CKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICEN 2351
Query: 280 GRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKL------- 330
GRCV + S+RC+ + +S C + C + R L
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2411
Query: 331 CNGVNDCGDNSDESP-------QQNCRPRTGE-------ENCNVNNGGCAQ-KCQMVRGA 375
C+G G + P ++ C G + C V C +C G+
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGS 2471
Query: 376 VQCTCHTGYRLTEDGHTCQDVNECAEEGY-CSQGCTNSEGAFQCWCETGYELRPDRRSCK 434
+C C GY G +C D++EC++ C+ C N+EG++QC C GY L+ D ++CK
Sbjct: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK 2531
Query: 435 AL 436
L
Sbjct: 2532 DL 2533
Score = 84.7 bits (208), Expect = 8e-16
Identities = 86/374 (22%), Positives = 143/374 (38%), Gaps = 69/374 (18%)
Query: 110 CEEDEFPCQNGYCIRSL--WHCDGDNDCGDNSDEQC-DMRKCSDKEFRCSDGSCIAE--H 164
C+ C NG CI ++ + C+ + +++ C D+ +C+ C++G C+
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--CTNGDCVNTPGS 555
Query: 165 WYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDC------GD 218
+YC + ++ C + C C GRC+ + DG C
Sbjct: 556 YYCKCHAGFQRTPTKQAC---IDIDECIQNGVLCKNGRCV----NTDGSFQCICNAGFEL 608
Query: 219 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQS------DERNCTTSMCTA 272
+D +C H C + MC +G+CIN DG C + + R CT
Sbjct: 609 TTDGKNCVDHDECTTTN-MCLNGMCINE----DGSFKCICKPGFVLAPNGRYCTDVDECQ 663
Query: 273 EQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNG--RCIGQR 328
C +G C+ S+RCD A D C +T + C+ G + + R
Sbjct: 664 TPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHM------RSTCYGGIKKGVCVR 717
Query: 329 KLCNGVND---CGDNSDESPQQNCRPRTGEEN----------------------CNVNNG 363
V C N D + C+P + + C ++
Sbjct: 718 PFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPD 777
Query: 364 GCAQK-CQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC-AEEGYCSQG-CTNSEGAFQCWC 420
CA C+ +RG+ +C C++GY G C D++EC C G C N+ G++ C C
Sbjct: 778 ICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTC 837
Query: 421 ETGYELRPDRRSCK 434
GY R + +C+
Sbjct: 838 PPGYVFRTETETCE 851
Score = 82.0 bits (201), Expect = 5e-15
Identities = 75/262 (28%), Positives = 110/262 (41%), Gaps = 58/262 (22%)
Query: 198 CAYGRCILDI--YHCDGDDDCGDWSDESD----CSSHQPCRSGEFMCDSGL-CIN----- 245
CA G CI I + C+ C +D C C +G+ +C CIN
Sbjct: 1819 CANGVCINQIGSFRCE----CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSY 1874
Query: 246 -----AGWRCDGDADCDDQSD----ERNCTTSMCT----AEQFRCHSG-RCVRLSWRCDG 291
AG++ + C D+++ C+ +C + Q CH+G + + C
Sbjct: 1875 RCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMD 1934
Query: 292 EDDCADNS-DEENCENT-GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNC 349
D+C + C+NT GS C LC+ G + C +++C Q C
Sbjct: 1935 VDECERHPCGNGTCKNTVGSYNC-----LCYPGFELTHNNDCLDIDECSSFFG----QVC 1985
Query: 350 RPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC-AEEGYCSQG 408
R NG C + G+ +C C+ GY LT DG C D NEC A G CS G
Sbjct: 1986 R-----------NGRCFNEI----GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPG 2030
Query: 409 -CTNSEGAFQCWCETGYELRPD 429
C N EG+F+C C GYE++ +
Sbjct: 2031 TCQNLEGSFRCICPPGYEVKSE 2052
Score = 76.3 bits (186), Expect = 3e-13
Identities = 102/441 (23%), Positives = 151/441 (34%), Gaps = 97/441 (21%)
Query: 27 CGRSHFTCAVSALG-----ECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNG 81
C ++ CA + ECTC P + D DE L C C N
Sbjct: 2257 CAQNPLLCAFRCMNTFGSYECTC-PIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN- 2314
Query: 82 KCIRRSWVCDGDNDCEDDSDEQDC-PPRECEEDEFPCQNGYCIRSL--WHCDGDNDCGDN 138
+ +++C D + C EC C+NG C+ + + C+ C +
Sbjct: 2315 --LIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE----CNEG 2368
Query: 139 SDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQC 198
+C D G C AE T C+ S N + + +C
Sbjct: 2369 FQSSSSGTECLDNR----QGLCFAEVL----QTICQMASSSRNL----------VTKSEC 2410
Query: 199 AYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDD 258
CDG W + + + +C G G+ DG D D+
Sbjct: 2411 C----------CDGGRG---WGHQCELCPLPGTAQYKKICPHG----PGYTTDG-RDIDE 2452
Query: 259 QSDERN-CTTSMC--TAEQFRCHS--GRCVRLSWR-CDGEDDCADNSDEEN--CENT-GS 309
N CT C T FRC G +S C D+C+ + N C+NT GS
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
Query: 310 PQCALDQFLCWNGRCIGQR-KLCNGVNDCGDNSDESPQQNCR----------------PR 352
QC+ C G + + K C +++C ++ Q NC+
Sbjct: 2513 YQCS-----CPRGYVLQEDGKTCKDLDEC-----QTKQHNCQFLCVNTLGGFTCKCPPGF 2562
Query: 353 TGEENCNVNNGGCAQK---------CQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEG 403
T ++N C + CQ G+ C C G+ L G C+DV+EC
Sbjct: 2563 TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNH 2622
Query: 404 YCSQGCTNSEGAFQCWCETGY 424
C GC N G ++C C GY
Sbjct: 2623 RCQHGCQNILGGYRCGCPQGY 2643
Score = 75.1 bits (183), Expect = 6e-13
Identities = 55/182 (30%), Positives = 78/182 (42%), Gaps = 29/182 (15%)
Query: 264 NCTTSMCTAEQFRCHSGRCVRL--SWRCD-----GEDDCADNSDEENCENTGSPQCALDQ 316
N T +C C +GRC+ S+RC+ +D D D + C T +P
Sbjct: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDEC--TSNP------ 543
Query: 317 FLCWNGRCIGQ--RKLCNGVNDCGDNSDESP-QQNCRPRTGEENCNVNNGGCAQ-KCQMV 372
C NG C+ C C +P +Q C + C N C +C
Sbjct: 544 --CTNGDCVNTPGSYYCK----CHAGFQRTPTKQAC---IDIDECIQNGVLCKNGRCVNT 594
Query: 373 RGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYELRPDRR 431
G+ QC C+ G+ LT DG C D +EC C G C N +G+F+C C+ G+ L P+ R
Sbjct: 595 DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGR 654
Query: 432 SC 433
C
Sbjct: 655 YC 656
Score = 70.5 bits (171), Expect = 2e-11
Identities = 96/449 (21%), Positives = 153/449 (34%), Gaps = 110/449 (24%)
Query: 42 CTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIR--RSWVCDGDNDCEDD 99
C C P + C D ++ C C+NG+C+ S+ C+ + +
Sbjct: 2321 CICPPGMARRPDGEGCVDENE--------CRTKPGICENGRCVNIIGSYRCECNEGFQSS 2372
Query: 100 SDEQDCPPRE-----CEEDEFPCQNGYCIRSLWH-----CDGDNDCGDNSD--------- 140
S +C E + CQ R+L CDG G +
Sbjct: 2373 SSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQ 2432
Query: 141 -------------EQCDMRKCSDKEFRCSDGSCIAE--HWYCDGDTDCKDG-SDEENCPS 184
+ D+ +C C++G CI + C CK G + + + S
Sbjct: 2433 YKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCF----CKVGYTTDISGTS 2488
Query: 185 AVPAPPCNLEEFQCAY-GRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLC 243
+ C+ C Y + Y C D C C++ + C LC
Sbjct: 2489 CIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF-LC 2547
Query: 244 INA--GWRC-------DGDADCDDQSDERNCTTSMCTAE--------QFRCHSGRCVRLS 286
+N G+ C C D ++E S+C A+ F C R L
Sbjct: 2548 VNTLGGFTCKCPPGFTQHHTACID-NNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLD 2606
Query: 287 ---WRCDGEDDCADNSD-EENCENT------GSPQCALDQFLCWNGRCIGQRKLCNGVND 336
C+ D+C N + C+N G PQ + + WN +C+ + + C+ N
Sbjct: 2607 ATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ-WN-QCVDENE-CSNPNA 2663
Query: 337 CGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDV 396
CG S C G+ +C C +G+ + C DV
Sbjct: 2664 CGSAS---------------------------CYNTLGSYKCACPSGFSFDQFSSACHDV 2696
Query: 397 NEC-AEEGYCSQGCTNSEGAFQCWCETGY 424
NEC + + C+ GC+N+EG + C C GY
Sbjct: 2697 NECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
Score = 68.2 bits (165), Expect = 7e-11
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 50/228 (21%)
Query: 231 CRSGEFMCDSGLCIN--AGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWR 288
C+ +C +G+CIN +RC+ C T + C +
Sbjct: 1812 CKEIPGICANGVCINQIGSFRCE-------------CPTGFSYNDLLLV----CEDIDEC 1854
Query: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN 348
+G++ C N+D N + +CA L NG C+ + N+C + +
Sbjct: 1855 SNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR-------NECLEIPNVCSHGL 1907
Query: 349 CRPRTGEENCNVNNGGCAQK--------------------CQMVRGAVQCTCHTGYRLTE 388
C G C +NG A + C+ G+ C C+ G+ LT
Sbjct: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967
Query: 389 DGHTCQDVNECAE--EGYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
+ + C D++EC+ C G C N G+F+C C GYEL PD ++C
Sbjct: 1968 N-NDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC 2014
Score = 67.0 bits (162), Expect = 2e-10
Identities = 120/554 (21%), Positives = 179/554 (32%), Gaps = 168/554 (30%)
Query: 22 SPECACGRSH----FTCA----------VSALGECTCIPAQWQCDGD------------N 55
S CAC FTC+ + G+C +P ++C+ +
Sbjct: 1431 SYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ 1490
Query: 56 DCGDHSDEDGCILPTCSPLD--FHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEED 113
D + S ++ C+ TC+ L FHC +CD + E D +C + D
Sbjct: 1491 DIDECSFQNICVFGTCNNLPGMFHC----------ICD--DGYELDRTGGNCTDIDECAD 1538
Query: 114 EFPCQNGYCIRS--LWHCDGDND---------CGDNSDEQCDMR--KCSDKEFRC----- 155
C NG C+ + + C+ D C DN C ++ D C
Sbjct: 1539 PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIG 1598
Query: 156 ---SDGSC---IAEHWYCDGDTDCKDGSDEEN--CPSAVPAPPC-------NLEEFQ--- 197
S SC + + W +T S E CP P +++E Q
Sbjct: 1599 VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658
Query: 198 --CAYGRCI--LDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA--GWRC- 250
C G CI + C+ D C C + +C G C N + C
Sbjct: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCI 1718
Query: 251 --------DGDADCDDQSDE---RNCTTSMCTAE-QFRCHSGRCVRLSWRCDGEDDCADN 298
+G +C D R+ + C E F C C A N
Sbjct: 1719 CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCC-----CTYNVGKAWN 1773
Query: 299 SDEENCENTGSP-------------------------QCALDQFLCWNGRCIGQ------ 327
E C G+ +C +C NG CI Q
Sbjct: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRC 1833
Query: 328 -----------RKLCNGVNDCGDNSDESPQQN--CRPRTGEENCNVN-------NGGCAQ 367
+C +++C N D Q+N C G C NG C
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDECS-NGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVD 1892
Query: 368 K--------------CQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNS 412
+ C ++G+ QC CH G++ ++D C DV+EC E C G C N+
Sbjct: 1893 RNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNT 1951
Query: 413 EGAFQCWCETGYEL 426
G++ C C G+EL
Sbjct: 1952 VGSYNCLCYPGFEL 1965
Score = 55.1 bits (131), Expect = 7e-07
Identities = 91/394 (23%), Positives = 129/394 (32%), Gaps = 86/394 (21%)
Query: 40 GECTCIPAQWQCDGDNDCGDHSDEDGCI-LPTCSPLDFHCDNGKCIRR--SWVCDGDNDC 96
G+C P + C + CI + C C NG+C+ S+ C +
Sbjct: 547 GDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGF 606
Query: 97 EDDSDEQDCPPR-ECEEDEFPCQNGYCIRSLWHCDGDNDC--------GDNSDEQCDMRK 147
E +D ++C EC C NG CI DG C N D+ +
Sbjct: 607 ELTTDGKNCVDHDECTTTNM-CLNGMCINE----DGSFKCICKPGFVLAPNGRYCTDVDE 661
Query: 148 CSDKEFRCSDGSCIAEH--WYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCIL 205
C C +G CI + CD G D C C G C+
Sbjct: 662 CQTPGI-CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCY---GGIKKGVCVR 717
Query: 206 DIYHCDGDDDC----GDWSDESDCSSHQPC---RSGEF--MCDSGLCINAGWRCDGDADC 256
+C D+ C QPC S EF +C SG+ I R
Sbjct: 718 PFPGAVTKSECCCANPDYGFGEPC---QPCPAKNSAEFHGLCSSGVGITVDGR------- 767
Query: 257 DDQSDERNCTTSMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCAL 314
+ C + C +G C L S+RC+ ++ NC + +C +
Sbjct: 768 ---------DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDID--ECLV 816
Query: 315 DQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRP----RTGEENC-NVN-------- 361
++ LC NG C N+ S C P RT E C ++N
Sbjct: 817 NRLLCDNGLC--------------RNTPGSYSCTCPPGYVFRTETETCEDINECESNPCV 862
Query: 362 NGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQD 395
NG C G+ C C G +L+ G C D
Sbjct: 863 NGACRNNL----GSFNCECSPGSKLSSTGLICID 892
Score = 54.7 bits (130), Expect = 9e-07
Identities = 68/266 (25%), Positives = 93/266 (34%), Gaps = 50/266 (18%)
Query: 202 RCILDIYHCDGDDDCGDWSDESDCSSHQ---PCRSGEFMCDSGLCINAGWRCDGDADCDD 258
+CI+ I D + CSS Q C S S C+N G D C
Sbjct: 109 QCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQK 168
Query: 259 QSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFL 318
C +C + C +G RC G + CA PQC D
Sbjct: 169 GYIGTYCGQPVC---ENGCQNGG------RCIGPNRCAC------VYGFTGPQCERDYRT 213
Query: 319 --CW----NGRCIGQRK--LCNGVNDC-------GDNSDESPQQNCRPRTGEENCNVNNG 363
C+ N C GQ +C C G + P Q R G N+ G
Sbjct: 214 GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIP-NIRTG 272
Query: 364 GC--AQKCQMVRGAVQ------------CTCHTGYRLTEDGHTCQDVNECA-EEGYCSQG 408
C +CQ + G Q C C G++ +E C+D++EC+ G C G
Sbjct: 273 ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
Query: 409 -CTNSEGAFQCWCETGYELRPDRRSC 433
C+N+ G++ C C GY D C
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRC 358
Score = 50.4 bits (119), Expect = 2e-05
Identities = 71/259 (27%), Positives = 90/259 (34%), Gaps = 62/259 (23%)
Query: 212 GDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCT 271
G + CG C + G C +C N+ C GD C S CT C+
Sbjct: 85 GPNVCGSRFHSYCCPGWKTLPGGN-QCIVPICRNS---C-GDGFC---SRPNMCT---CS 133
Query: 272 AEQFR--CHSGRCVRLSWRCDGEDDCADNSDEENCEN------TGSPQCALDQFLCWNG- 322
+ Q C S + S RC CAD D C+ G P C C NG
Sbjct: 134 SGQISSTCGSKSIQQCSVRCMNGGTCAD--DHCQCQKGYIGTYCGQPVCENG---CQNGG 188
Query: 323 RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCT--- 379
RCIG + G PQ RTG VNN Q CQ + CT
Sbjct: 189 RCIGPNRCACVYGFTG------PQCERDYRTGPCFTQVNN----QMCQGQLTGIVCTKTL 238
Query: 380 ----------------------CHTGYRLTEDGHTCQDVNEC-AEEGYCSQG-CTNSEGA 415
C G+ CQDV+EC A G C G C N+ G+
Sbjct: 239 CCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS 298
Query: 416 FQCWCETGYELRPDRRSCK 434
F+C C G++ + C+
Sbjct: 299 FECRCPAGHKQSETTQKCE 317
Score = 48.9 bits (115), Expect = 5e-05
Identities = 87/383 (22%), Positives = 139/383 (36%), Gaps = 99/383 (25%)
Query: 109 ECEEDEFPCQNGYCIRSLWHCDGDNDC-------GDNSDEQC-DMRKCSDKEFRCS---- 156
EC+ C NG CI ++ G C D S C D+ +CS C+
Sbjct: 2452 ECKVMPNLCTNGQCINTM----GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICK 2507
Query: 157 --DGS--CIAEHWYC---DGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDI-- 207
+GS C Y DG T CKD + C ++ C + C+ +
Sbjct: 2508 NTEGSYQCSCPRGYVLQEDGKT-CKDLDE------------CQTKQHNCQF-LCVNTLGG 2553
Query: 208 -----------YH--CDGDDDCGDWSDESDCSSHQPCRS--GEFMCDS--GLCINA-GWR 249
+H C +++CG S S C + C++ G F C+ G ++A G
Sbjct: 2554 FTCKCPPGFTQHHTACIDNNECG--SQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLN 2611
Query: 250 CDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSW-RCDGEDDCADNS--DEENCEN 306
C+ +CD ++ ++ + C G W +C E++C++ + +C N
Sbjct: 2612 CEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYN 2671
Query: 307 T-GSPQCALDQFLCWNGRCIGQ-RKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGG 364
T GS +CA C +G Q C+ VN+C +S ++P
Sbjct: 2672 TLGSYKCA-----CPSGFSFDQFSSACHDVNEC--SSSKNP------------------- 2705
Query: 365 CAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCS-------QGCTNSEGAFQ 417
C C G C C GY GH C + Y S + + E ++
Sbjct: 2706 CNYGCSNTEGGYLCGCPPGYYRVGQGH-CVSGMGFNKGQYLSLDTEVDEENALSPEACYE 2764
Query: 418 CWCETGYELRPDRRSCKALGPEP 440
C GY + R+ P+P
Sbjct: 2765 CKI-NGYSKKDSRQKRSIHEPDP 2786
Score = 48.1 bits (113), Expect = 8e-05
Identities = 78/327 (23%), Positives = 109/327 (33%), Gaps = 72/327 (22%)
Query: 117 CQNGYCIR-SLWHCDG---DNDCGDNSDEQCDMR-----KCSDKEFRCSDGSCIAEHWYC 167
C +G+C R ++ C + CG S +QC +R C+D +C G YC
Sbjct: 119 CGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGT---YC 175
Query: 168 DGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSS 227
G C++G +N + C C YG C+ D G + +
Sbjct: 176 -GQPVCENGC--QNGGRCIGPNRC-----ACVYG---FTGPQCERDYRTGPCFTQVNNQM 224
Query: 228 HQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRL-S 286
Q +G +C LC R G C+ MC A+ C G + +
Sbjct: 225 CQGQLTG-IVCTKTLCCATIGRAWGHP-CE-----------MCPAQPQPCRRGFIPNIRT 271
Query: 287 WRCDGEDDCA---DNSDEENCENT-GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSD 342
C D+C NC NT GS +C RC K C D +
Sbjct: 272 GACQDVDECQAIPGICQGGNCINTVGSFEC----------RCPAGHKQSETTQKCEDIDE 321
Query: 343 ESPQQNCRPRTGEENCNVNNGGCAQ-KCQMVRGAVQCTCHTGYRLTEDGHTC--QDVNEC 399
C++ G C +C G+ C C GY + DG C Q C
Sbjct: 322 ---------------CSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMC 366
Query: 400 AE---EGYCSQGCTNSEGAFQCWCETG 423
G C+Q QC CE G
Sbjct: 367 FSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 38.1 bits (87), Expect = 0.083
Identities = 13/41 (31%), Positives = 22/41 (53%)
Query: 1308 LGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
+ ++C C+++C + C+CP G L+ DGKTC
Sbjct: 2490 IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Score = 37.0 bits (84), Expect = 0.18
Identities = 15/46 (32%), Positives = 21/46 (45%)
Query: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
DR ++C NGGC C + C+C G L DG++C
Sbjct: 1236 DRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
Score = 35.8 bits (81), Expect = 0.41
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCS 1044
C + NGGC C S + C+C G L+ DG++C+
Sbjct: 1246 CMIMNGGCDTQCTNSEG--SYECSCSEGYALMPDGRSCA 1282
Score = 34.7 bits (78), Expect = 0.91
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Query: 1311 NKCGSRNG--GCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPE 1353
N+CGS+ G +C P FSC C G L G C+ E
Sbjct: 2573 NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDE 2617
Score = 33.5 bits (75), Expect = 2.0
Identities = 13/38 (34%), Positives = 20/38 (52%), Gaps = 2/38 (5%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
C+ C+++C + + C+CP G L DGKTC
Sbjct: 2495 CSQSPKPCNYICKNTEG--SYQCSCPRGYVLQEDGKTC 2530
Score = 32.3 bits (72), Expect = 4.5
Identities = 11/32 (34%), Positives = 17/32 (53%)
Query: 1324 CLPRPSGFSCACPTGIQLKGDGKTCDPSPETY 1355
C P GF C CP G L +G+ C + +++
Sbjct: 2072 CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF 2103
Score = 32.3 bits (72), Expect = 4.5
Identities = 10/41 (24%), Positives = 17/41 (41%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSL 740
N C + C + C + Y C CP G+ ++ C +
Sbjct: 2697 NECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGM 2737
Score = 32.0 bits (71), Expect = 5.9
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1311 NKCGSRNGGCSH-LCLPRPSGFSCACPTGIQLKGDGKTC 1348
N+C G C + C+ F C CP G+ L G G+ C
Sbjct: 957 NECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
Score = 32.0 bits (71), Expect = 5.9
Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 6/49 (12%)
Query: 1607 SPQRQ--TGTNACGVNNGGCTHLCFARASDFVCACPD----EPDSRPCS 1649
+P RQ T + C + NGGC C + C+C + PD R C+
Sbjct: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1282
Score = 32.0 bits (71), Expect = 5.9
Identities = 12/35 (34%), Positives = 16/35 (45%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDG 1345
N+C S C++ C G+ C CP G G G
Sbjct: 2697 NECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG 2731
Score = 31.6 bits (70), Expect = 7.7
Identities = 27/102 (26%), Positives = 41/102 (40%), Gaps = 11/102 (10%)
Query: 1272 TRSIHRADKGTGSNVILVRS--NLPGLM-----DMQAVDRA--QPLGFNKCGSRNGGCSH 1322
+RS D+ + N+ + + NLPG+ D +DR ++C +
Sbjct: 1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNG 1545
Query: 1323 LCLPRPSGFSCACPTGIQLKGDGKTC--DPSPETYLLFSSRG 1362
LC+ P + C CP QL G C + YL F RG
Sbjct: 1546 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRG 1587
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 115 bits (287), Expect = 5e-25
Identities = 55/125 (44%), Positives = 77/125 (61%), Gaps = 5/125 (4%)
Query: 191 CNLE-EFQCAYGRCILDIYHCDGDDDCGDWSDESDC-SSHQPCRSGEFMCDSGL-CINAG 247
CN+ F C+ GRCI + CDG DC D SDE +C + C F C SG+ CI
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
Query: 248 WRCDGDADCDDQSDERNCTTS--MCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCE 305
+RC+G DC D SDE NCT + +C+ ++ C +G C+ S+ CDG+++C DNSDEE+CE
Sbjct: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
Query: 306 NTGSP 310
++ P
Sbjct: 149 SSQEP 153
Score = 110 bits (274), Expect = 2e-23
Identities = 57/127 (44%), Positives = 77/127 (60%), Gaps = 7/127 (5%)
Query: 234 GEFMCDSGLCINAGWRCDGDADCDDQSDERNC--TTSMCTAEQFRCHSG-RCVRLSWRCD 290
G FMC +G CI W+CDG DC D+SDE+ C S C F C SG C+ +RC+
Sbjct: 33 GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
Query: 291 GEDDCADNSDEENCENTGSPQ-CALDQFLCWNGRCIGQRKLCNGVNDCGDNSD-ESPQQN 348
G +DC D SDEENC T +P C+ ++ C NG CI + +C+G N+C DNSD ES + +
Sbjct: 93 GFEDCPDGSDEENC--TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
Query: 349 CRPRTGE 355
P +G+
Sbjct: 151 QEPGSGQ 157
Score = 109 bits (272), Expect = 3e-23
Identities = 51/119 (42%), Positives = 71/119 (59%), Gaps = 6/119 (5%)
Query: 73 PLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP--PRECEEDEFPCQNG-YCIRSLWHC 129
P +F C NG+CI +W CDG DC D SDE++CP +C FPC +G +CI + C
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
Query: 130 DGDNDCGDNSDEQ---CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
+G DC D SDE+ + CS + C +G CI + + CDG +C+D SDEE+C S+
Sbjct: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
Score = 101 bits (252), Expect = 6e-21
Identities = 57/130 (43%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 115 FPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRK--CSDKEFRCSDG-SCIAEHWYCDGD 170
F C NG CI W CDG DC D SDE +C K C F C+ G CI + C+G
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 171 TDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP 230
DC DGSDEENC +A P C+ + C G CI + CDG ++C D SDE C S Q
Sbjct: 95 EDCPDGSDEENC-TANPLL-CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
Query: 231 CRSGEFMCDS 240
SG+ S
Sbjct: 153 PGSGQVFVTS 162
Score = 96.7 bits (239), Expect = 2e-19
Identities = 58/144 (40%), Positives = 74/144 (51%), Gaps = 11/144 (7%)
Query: 9 LLGALLCAHGLASSPECACGRSHFT--CAVSALGECT---CIPAQWQCDGDNDCGDHSDE 63
LLG L A+ + G ++FT C + C+ CIP WQCDG DC D SDE
Sbjct: 3 LLGPLCLLLSSAAESQLLPG-NNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE 61
Query: 64 DGC--ILPTCSPLDFHCDNG-KCIRRSWVCDGDNDCEDDSDEQDCP--PRECEEDEFPCQ 118
C C P F C +G CI + C+G DC D SDE++C P C + C+
Sbjct: 62 KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK 121
Query: 119 NGYCIRSLWHCDGDNDCGDNSDEQ 142
NG CI + CDG N+C DNSDE+
Sbjct: 122 NGLCIDKSFICDGQNNCQDNSDEE 145
Score = 79.0 bits (193), Expect = 4e-14
Identities = 35/81 (43%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPT--CSPLDFHCDNGKCI 84
CG + F CA CI +++C+G DC D SDE+ C CS +HC NG CI
Sbjct: 71 CGPTFFPCASGI----HCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCI 126
Query: 85 RRSWVCDGDNDCEDDSDEQDC 105
+S++CDG N+C+D+SDE+ C
Sbjct: 127 DKSFICDGQNNCQDNSDEESC 147
Score = 71.6 bits (174), Expect = 7e-12
Identities = 45/121 (37%), Positives = 55/121 (45%), Gaps = 12/121 (9%)
Query: 264 NCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNG- 322
N T F C +GRC+ +W+CDG DC D SDE+ C S +C F C +G
Sbjct: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS-KCGPTFFPCASGI 82
Query: 323 RCIGQRKLCNGVNDCGDNSDESPQQNCRPR-----TGEENCNVNNGGCAQKCQMVRGAVQ 377
CI R CNG DC D SDE +NC T +C NG C K + G
Sbjct: 83 HCIIGRFRCNGFEDCPDGSDE---ENCTANPLLCSTARYHC--KNGLCIDKSFICDGQNN 137
Query: 378 C 378
C
Sbjct: 138 C 138
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 110 bits (275), Expect = 1e-23
Identities = 106/428 (24%), Positives = 162/428 (37%), Gaps = 61/428 (14%)
Query: 42 CTCIPAQWQ-----CDGDNDCGD-HSDEDGCI---LPTCSPLDFHCDNGKCI--RRSWVC 90
C+ + A W C D CG +S G + C C NG C+ R S+ C
Sbjct: 876 CSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKC 935
Query: 91 DGDNDCEDDSDEQDCPPRECE------EDE---FPCQNGY----CIRSLWHCDGDNDCGD 137
+ D+ + C E EDE P + C S+ G +C
Sbjct: 936 QCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEEC-- 993
Query: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQ 197
E+C MR + E C G A +G KD ++ + PS
Sbjct: 994 ---EECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSL------------ 1038
Query: 198 CAYGRC--ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDAD 255
C +G+C + + C D S+E +C+ CR +C G C+N D +
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPG--DFECK 1096
Query: 256 CDDQSDE-----RNCTT-SMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENT 307
CD+ + +NC C + C G C S+RC+ + + C +
Sbjct: 1097 CDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDI 1156
Query: 308 GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367
+C L LC NGRC+ G C N + + C++ NGGC
Sbjct: 1157 N--ECELSAHLCPNGRCVN----LIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCET 1210
Query: 368 KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEE-GYCSQG-CTNSEGAFQCWCETGYE 425
C G+ +C+C G+ L D +C D++EC + C G CTN G ++C C G+
Sbjct: 1211 FCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFM 1270
Query: 426 LRPDRRSC 433
D ++C
Sbjct: 1271 ASEDMKTC 1278
Score = 102 bits (254), Expect = 4e-21
Identities = 101/427 (23%), Positives = 161/427 (37%), Gaps = 76/427 (17%)
Query: 71 CSPLDFHCDNGKCIRR--SWVCDGDNDCEDDSDEQDCPP-RECEEDEFPCQNGYCIRSLW 127
C + C +GKC S+ C D+ DS+E++C EC C G C+ +
Sbjct: 1032 CKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPG 1091
Query: 128 H----CDGDNDCGDNSDEQC-DMRKCSDKEFRCSDGSC--IAEHWYCDGDTDCKDGSD-E 179
CD + G + C D+ +C C G C + C+ C G
Sbjct: 1092 DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCE----CPPGHQLS 1147
Query: 180 ENCPSAVPAPPCNLEEFQCAYGRCI--LDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFM 237
N + + C L C GRC+ + Y C + D C C
Sbjct: 1148 PNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGG 1207
Query: 238 CDSGLCINAGWRCDGDADCDDQS------DERNCTT-SMCTAEQFRCHSGRCVRL--SWR 288
C++ C N+ +G +C Q D+R+CT C C G+C + +R
Sbjct: 1208 CET-FCTNS----EGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYR 1262
Query: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKL-----------------C 331
C D + D + C + +C L+ +C +G C + C
Sbjct: 1263 CLCYDGFMASEDMKTCVDVN--ECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGC 1320
Query: 332 NGVNDCG------------DNSDESPQQNCRPR--------TGEENCNVNNGGCAQK--C 369
+N+C N+ S + +C P T + C+ C+Q C
Sbjct: 1321 TDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADC 1380
Query: 370 QMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEE-GYCSQG-CTNSEGAFQCWCETGYELR 427
+ G+ +C C GY T DG TC D++EC+E C G C N+ G ++C C+ G+
Sbjct: 1381 KNTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPS 1438
Query: 428 PDRRSCK 434
D ++C+
Sbjct: 1439 ADGKACE 1445
Score = 94.4 bits (233), Expect = 1e-18
Identities = 94/387 (24%), Positives = 152/387 (39%), Gaps = 56/387 (14%)
Query: 71 CSPLDFHCDNGKCIRR--SWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRS--- 125
C + + C NG+CI S C+ + + D + ECE++ PC G CI +
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKN--PCAGGECINNQGS 510
Query: 126 -LWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEH--WYCDGDTDCKDGSDEENC 182
C E D+ +C C++G CI ++C + D +NC
Sbjct: 511 YTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNC 570
Query: 183 PSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDC------GDWSDESDCSSHQPCRSGEF 236
C++ C G CI + DG C SD C C +
Sbjct: 571 EDM---DECSIRNM-CLNGMCINE----DGSFKCICKPGFQLASDGRYCKDINECETPG- 621
Query: 237 MCDSGLCINA--GWRCDGDADCDDQSDERNCTTSMCTAEQFRCHS-GRCVRLSWRCDGED 293
+C +G C+N +RC+ D R C + + + + G+C++ + +
Sbjct: 622 ICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKS 681
Query: 294 DCADNSDE----ENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNC 349
+C S E E C+ + A Q LC +G G + +N+C + D P
Sbjct: 682 ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGP--GMTSAGSDINECALDPDICP---- 735
Query: 350 RPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY-CSQG 408
NG C+ +RG +C C++GY + G C D+NEC C G
Sbjct: 736 ------------NG----ICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNG 779
Query: 409 -CTNSEGAFQCWCETGYELRPDRRSCK 434
C N+ G+F C C G+ +PD ++C+
Sbjct: 780 QCRNTPGSFVCTCPKGFIYKPDLKTCE 806
Score = 89.0 bits (219), Expect = 4e-17
Identities = 107/427 (25%), Positives = 154/427 (36%), Gaps = 65/427 (15%)
Query: 40 GECTCIPAQWQC---DG---DNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGD 93
G+CT IP +++C DG D D + C L L C+N K S++C D
Sbjct: 1252 GQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTK---GSFICHCD 1308
Query: 94 NDCEDDSDEQDCPP-RECEEDEFPC-QNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDK 151
+ C ECE C ++ C + G C + D KC+D
Sbjct: 1309 MGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTA----GSFKCSCSPGWIGDGIKCTDL 1364
Query: 152 EFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP----------SAVPAPPCNLEEFQCAYG 201
+ CS+G+ + C DCK+ C + C+ C G
Sbjct: 1365 D-ECSNGTHM-----CSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNG 1418
Query: 202 RCILDI--YHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAG--WRCDGDADCD 257
+C+ Y C+ D +D C C S +C G C N +RC+ + +
Sbjct: 1419 QCLNAPGGYRCECDMGFVPSADGKACEDIDEC-SLPNICVFGTCHNLPGLFRCECEIGYE 1477
Query: 258 DQSDERNCTTSMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALD 315
NCT + C SG CV S+ CD D N C +T S C LD
Sbjct: 1478 LDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLD 1537
Query: 316 QFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGC----AQKCQM 371
+ GDN D + + +C + G + C
Sbjct: 1538 ------------------IRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPA 1579
Query: 372 VRGA---VQCTCHTGYRLTEDGHTCQDVNECAE-EGYCSQG-CTNSEGAFQCWCETGYEL 426
V + + C G+R +D++EC E G C G C N+ G+FQC C TGY L
Sbjct: 1580 VNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1639
Query: 427 RPDRRSC 433
D R C
Sbjct: 1640 NEDTRVC 1646
Score = 89.0 bits (219), Expect = 4e-17
Identities = 100/408 (24%), Positives = 163/408 (39%), Gaps = 86/408 (21%)
Query: 83 CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRS--LWHCD-------GDN 133
C S + G +D D DE C+E + C++G CI + + C+ N
Sbjct: 2111 CPYGSGIIVGPDDSAVDMDE-------CKEPDV-CKHGQCINTDGSYRCECPFGYILAGN 2162
Query: 134 DCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNL 193
+C D ++C + C +G+C ++ + C++G + + C
Sbjct: 2163 ECVDT--DECSVGN------PCGNGTC--KNVIGGFECTCEEGFEPGPMMTCEDINECAQ 2212
Query: 194 EEFQCAYGRCIL-----------------DIYHCDGDDDCGDWSDESDCSSHQ-PCRS-- 233
CA+ RC+ D C +D+C + + DC+ Q C++
Sbjct: 2213 NPLLCAF-RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEE--GKHDCTEKQMECKNLI 2269
Query: 234 GEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCV--RLSWRCDG 291
G +MC G R DG+ C D+++ C + C +GRC+ R S+ C+
Sbjct: 2270 GTYMCICGPGYQR--RPDGEG-CVDENE--------CQTKPGICENGRCLNTRGSYTCEC 2318
Query: 292 EDDCADNSDEENCENTGSPQCALD--QFLCWNGRC-----IGQRKLCNGVNDCGDNSDES 344
D + +++ C + C + Q +C G C+G G + +
Sbjct: 2319 NDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEIC 2378
Query: 345 PQQN-------CRPRTGE-------ENCNVNNGGCAQ-KCQMVRGAVQCTCHTGYRLTED 389
P Q C G + C V + C +C RG+ C C TGY
Sbjct: 2379 PFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDIT 2438
Query: 390 GHTCQDVNECAEEGY-CSQGCTNSEGAFQCWCETGYELRPDRRSCKAL 436
G +C D+NEC + C+ C N+EG++QC C GY L+ D RSCK L
Sbjct: 2439 GTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDL 2486
Score = 84.3 bits (207), Expect = 1e-15
Identities = 105/430 (24%), Positives = 154/430 (35%), Gaps = 99/430 (23%)
Query: 71 CSPLDFHCDNGKCIRR-----------------SWVCDGDNDCEDDSDEQDCPPRECEED 113
C L C GKCI + VCD N+CE C P C
Sbjct: 1610 CQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGI---CGPGTCYNT 1666
Query: 114 --EFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCI----AEHWYC 167
+ C C +G N+C D C +D + DG + + C
Sbjct: 1667 VGNYTC---ICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQ--TCDGELLFNMTKKMCCC 1721
Query: 168 DGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGR----CILDIYHCDGDDDCGDWSDES 223
+ E CP +P+ +EF G ++DIY D DE
Sbjct: 1722 SYNIGRAWNKPCEQCP--IPST----DEFATLCGSQRPGFVIDIYTGLPVD-----IDE- 1769
Query: 224 DCSSHQPCRSGEFMCDSGLCIN--AGWRCDGDAD---------CDDQSDERNCTTSMCTA 272
CR +C++G+CIN +RC+ C+D + +N A
Sbjct: 1770 -------CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNA 1822
Query: 273 EQFR-CHSGRC-VRLSWRCDGEDDCADNSDEENCENTGSPQCALDQF-----LCWNG-RC 324
E S RC + +R C D ++ + N S +D LC G +
Sbjct: 1823 ECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882
Query: 325 IGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNG-------------GCAQ---- 367
+ +C +N+C D CR G NC N+G CA
Sbjct: 1883 NDDQTMCLDINEC--ERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGN 1940
Query: 368 -----KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC-AEEGYCSQG-CTNSEGAFQCWC 420
+C G+ QC C+ GY + DG TC D+NEC E C+ G C N +G+++C C
Sbjct: 1941 LCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCIC 2000
Query: 421 ETGYELRPDR 430
GY L+ ++
Sbjct: 2001 PPGYSLQNEK 2010
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/337 (24%), Positives = 131/337 (38%), Gaps = 58/337 (17%)
Query: 109 ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQC----DMRKCSDKEFRCSDGSCI--A 162
EC E C+NG CI + + G +++ D+ +C + + CI A
Sbjct: 1769 ECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTA 1828
Query: 163 EHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE 222
+ CD CK G + C C++G+CI D G +
Sbjct: 1829 GSYRCD----CKPGYRFTSTGQCNDRNECQEIPNICSHGQCI---------DTVGSFY-- 1873
Query: 223 SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282
C H ++ + D +C++ C+ DA C + + + C RC+ G
Sbjct: 1874 --CLCHTGFKTND---DQTMCLDIN-ECERDA-CGNGTCRNTIGSFNC-----RCNHGFI 1921
Query: 283 VRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSD 342
+ + C D+CA + LC NG+CI G C N
Sbjct: 1922 LSHNNDCIDVDECASGNGN----------------LCRNGQCINTV----GSFQCQCNEG 1961
Query: 343 ESPQQNCRPRTGEENCNVNNGGCAQ-KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAE 401
+ R C + CA CQ + G+ +C C GY L + C+D++EC E
Sbjct: 1962 YEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE--KCEDIDECVE 2019
Query: 402 EG-YCSQG-CTNSEGAFQCWCETGYELRPDRRSCKAL 436
E C+ G C+N+EG+F+C C G+ L R C+ L
Sbjct: 2020 EPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDL 2056
Score = 77.4 bits (189), Expect = 1e-13
Identities = 102/442 (23%), Positives = 153/442 (34%), Gaps = 99/442 (22%)
Query: 27 CGRSHFTCAVSALG-----ECTCIPAQWQCDGDNDCGDHSD-EDGCILPTCSPLDFHCDN 80
C ++ CA + EC C + C D + E+G C+ C N
Sbjct: 2210 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEG--KHDCTEKQMECKN 2267
Query: 81 GKCIRRSWVCDGDNDCEDDSDEQDC-PPRECEEDEFPCQNGYCI--RSLWHCDGDNDCGD 137
+ +++C + D + C EC+ C+NG C+ R + C+ C D
Sbjct: 2268 ---LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCE----CND 2320
Query: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPA--------- 188
+ +C D +G C E C+ GS N +
Sbjct: 2321 GFTASPNQDECLDNR----EGYCFTEVL----QNMCQIGSSNRNPVTKSECCCDGGRGWG 2372
Query: 189 PPCNLEEFQ--------CAYGRCILDIYHCDGDDDCGDWSDESDCSS-HQPCRSGEFMCD 239
P C + FQ C +GR + + +D +C H CR+GE + D
Sbjct: 2373 PHCEICPFQGTVAFKKLCPHGRGFMT-----------NGADIDECKVIHDVCRNGECVND 2421
Query: 240 SGL--CI-NAGWRCDGDADCDDQSDERNCTTSMCT--------AEQFRCHSGRCVRLSWR 288
G CI G+ D +E N C + Q C G ++ R
Sbjct: 2422 RGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGR 2481
Query: 289 -CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
C D+CA + + NC QFLC VN G + + P
Sbjct: 2482 SCKDLDECA--TKQHNC-----------QFLC--------------VNTIGGFTCKCPPG 2514
Query: 348 NCRPRTG---EENCNVNNGGCAQK--CQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEE 402
+ T C + C K CQ G+ C C G+ L + G +C+DV+EC
Sbjct: 2515 FTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN 2574
Query: 403 GYCSQGCTNSEGAFQCWCETGY 424
C GC N G ++C C GY
Sbjct: 2575 HRCQHGCQNIIGGYRCSCPQGY 2596
Score = 76.6 bits (187), Expect = 2e-13
Identities = 106/454 (23%), Positives = 155/454 (34%), Gaps = 76/454 (16%)
Query: 24 ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPT-CSPLDFHCDNGK 82
E C C + EC + + C D +GC+ C C+NG+
Sbjct: 2248 EDECEEGKHDCTEKQM-ECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR 2306
Query: 83 CI--RRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSD 140
C+ R S+ C+ ND S QD EC ++ + GYC + N C S
Sbjct: 2307 CLNTRGSYTCEC-NDGFTASPNQD----ECLDN----REGYCFTEVLQ----NMCQIGSS 2353
Query: 141 EQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP-------SAVPAPPCNL 193
+ + K E C G H C+ + ++ CP + C +
Sbjct: 2354 NRNPVTK---SECCCDGGRGWGPH--CEICPFQGTVAFKKLCPHGRGFMTNGADIDECKV 2408
Query: 194 EEFQCAYGRCILD--IYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA--GWR 249
C G C+ D YHC + C C C+ +C N ++
Sbjct: 2409 IHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNF-ICKNTEGSYQ 2467
Query: 250 CDGDADCDDQSDERNCTT-SMCTAEQFRCHSGRCVR----LSWRC-----DGEDDCADN- 298
C Q D R+C C +Q C CV + +C C DN
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECATKQHNCQF-LCVNTIGGFTCKCPPGFTQHHTSCIDNN 2526
Query: 299 ---SDEENCENTGSPQCALDQFLC--WNGRCIGQR-KLCNGVNDCGDNSDESPQQNCRPR 352
SD C + G Q F C G + Q C V++C N Q C+
Sbjct: 2527 ECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN--HRCQHGCQNI 2584
Query: 353 TGEENCNVNNG--------GCAQK-------------CQMVRGAVQCTCHTGYRLTEDGH 391
G C+ G C + C G+ +C C G++ +
Sbjct: 2585 IGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSG 2644
Query: 392 TCQDVNECAE-EGYCSQGCTNSEGAFQCWCETGY 424
CQD+NEC + CS GC+N+EG + C C GY
Sbjct: 2645 GCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 57.4 bits (137), Expect = 1e-07
Identities = 74/271 (27%), Positives = 101/271 (37%), Gaps = 50/271 (18%)
Query: 202 RCILDIY-HCDGDDDCGDWSDESDCSSHQPCRSGEFM--CDSGLCINAGWRCDGDADCDD 258
+CI+ I H GD C S + C+ C SG+ C S + RC C D
Sbjct: 79 QCIVPICRHSCGDGFC---SRPNMCT----CPSGQIAPSCGSRSIQHCNIRCMNGGSCSD 131
Query: 259 QSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFL 318
+C +C H G+ V S +G A N TG PQC D
Sbjct: 132 D----HC---LCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTG-PQCERDYRT 183
Query: 319 --CW----NGRCIGQRK--LCNGVNDC-------GDNSDESPQQNCRPRTGEENCNVNNG 363
C+ N C GQ +C C G + P Q R G N+ G
Sbjct: 184 GPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIP-NIRTG 242
Query: 364 GC--AQKCQMVRGAVQ------------CTCHTGYRLTEDGHTCQDVNECAE-EGYCSQG 408
C +CQ + G Q C C G++L E C+D++EC+ G C G
Sbjct: 243 ACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGG 302
Query: 409 -CTNSEGAFQCWCETGYELRPDRRSCKALGP 438
CTN+ ++ C C G+ PD C + P
Sbjct: 303 ECTNTVSSYFCKCPPGFYTSPDGTRCIDVRP 333
Score = 40.4 bits (93), Expect = 0.017
Identities = 92/439 (20%), Positives = 144/439 (32%), Gaps = 123/439 (28%)
Query: 50 QCD-GDNDCGDHS---DEDGCILPTCSPL----DFHC-DNGKCIRRSWVCDGDNDCEDDS 100
+C+ G ++CG H+ + G +CSP C D +C + +C DC++
Sbjct: 1325 ECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTM 1384
Query: 101 DEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSC 160
C C+ GY GD + DE CS+ C +G C
Sbjct: 1385 GSYRCL----------CKEGYT--------GDGFTCTDLDE------CSENLNLCGNGQC 1420
Query: 161 IAEH--WYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRC--ILDIYHCDG---- 212
+ + C+ D +D + C C+L C +G C + ++ C+
Sbjct: 1421 LNAPGGYRCECDMGFVPSADGKACEDI---DECSLPNI-CVFGTCHNLPGLFRCECEIGY 1476
Query: 213 --DDDCGDWSDESDCSSHQPCRSGE-------FMCD------------------SGLC-I 244
D G+ +D ++C C SG ++CD SG C +
Sbjct: 1477 ELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYL 1536
Query: 245 NAGWRCD-GDADCDDQS----DERNCTTSMCTAEQFRCHSGRCVRLSWR---CDGEDDCA 296
+ R D GD C ++ + +C S+ A C V S C G +
Sbjct: 1537 DIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFR 1596
Query: 297 DNSDEENCENTGSPQCALDQFLCWNGRCIG-----------------QRKLCNGVNDCGD 339
N E+ +C LC G+CI ++C+ VN+C
Sbjct: 1597 PNPITVILEDID--ECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC-- 1652
Query: 340 NSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNE- 398
E+P C P T C G C C Y G+ C D+
Sbjct: 1653 ---ETPGI-CGPGT---------------CYNTVGNYTCICPPDYMQVNGGNNCMDMRRS 1693
Query: 399 -CAEEGYCSQGCTNSEGAF 416
C Y + E F
Sbjct: 1694 LCYRNYYADNQTCDGELLF 1712
Score = 36.6 bits (83), Expect = 0.24
Identities = 14/46 (30%), Positives = 21/46 (45%)
Query: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
DR + ++C NGGC C + C+C G L D ++C
Sbjct: 1191 DRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSC 1236
Score = 35.4 bits (80), Expect = 0.54
Identities = 12/38 (31%), Positives = 20/38 (52%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
N+C C+ +C + C+CP G L+ DG++C
Sbjct: 2446 NECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 34.7 bits (78), Expect = 0.91
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
++C RN + +C+ F C C G QL DG+ C
Sbjct: 574 DECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYC 611
Score = 34.7 bits (78), Expect = 0.91
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCS 1044
C++ NGGC C S + C+C G L+ D ++C+
Sbjct: 1201 CSIMNGGCETFCTNS--EGSYECSCQPGFALMPDQRSCT 1237
Score = 34.3 bits (77), Expect = 1.2
Identities = 14/35 (40%), Positives = 17/35 (48%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDG 1345
N+CGS CS+ C G+ C CP G G G
Sbjct: 2650 NECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQG 2684
Score = 33.9 bits (76), Expect = 1.6
Identities = 12/41 (29%), Positives = 18/41 (43%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSL 740
N CG C++ C + Y C CP G+ +I C +
Sbjct: 2650 NECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGM 2690
Score = 33.1 bits (74), Expect = 2.7
Identities = 13/43 (30%), Positives = 19/43 (44%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDK 742
+ C NGGC C S +Y C+C GF + +D+
Sbjct: 1199 DECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDE 1241
Score = 32.3 bits (72), Expect = 4.5
Identities = 16/46 (34%), Positives = 19/46 (41%), Gaps = 6/46 (13%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYL 1356
N CG+ CL P G+ C C G DGK C+ E L
Sbjct: 1413 NLCGNGQ------CLNAPGGYRCECDMGFVPSADGKACEDIDECSL 1452
Score = 31.6 bits (70), Expect = 7.7
Identities = 10/28 (35%), Positives = 16/28 (57%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTG 1338
++C ++ C LC+ GF+C CP G
Sbjct: 2487 DECATKQHNCQFLCVNTIGGFTCKCPPG 2514
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 108 bits (270), Expect = 5e-23
Identities = 109/427 (25%), Positives = 160/427 (37%), Gaps = 71/427 (16%)
Query: 41 ECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIR--RSWVCDGDNDCED 98
+C C P C D + CS D C +G+C+ ++ C +
Sbjct: 1095 KCQCPPGHELTAKGTACED--------IDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS 1146
Query: 99 DSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDN--DCGDNSDEQCDMRKCSDKEFRCS 156
D Q C + +E QNG C + +G CG D R C+D + C
Sbjct: 1147 TPDRQGC----VDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVD-ECE 1201
Query: 157 DGSCIAEHWYCDGDTD-----CKDG----SDEENCPSAVPAPPCNLEEFQCAYGRCILD- 206
+ + + +C C DG D C V C+L C +G C
Sbjct: 1202 ENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC---VDVDECDLNPHICLHGDCENTK 1258
Query: 207 ---IYHCD-------GDDDCGDWSD----ESDCSSHQPCRS--GEFMCDSGLCINAGWRC 250
+ HC G C D + +C SH C + G F C C+ GW
Sbjct: 1259 GSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR---CL-PGWVG 1314
Query: 251 DGDADCDDQSDERNCTTSMCTAEQFRCHS-GRCVRL--SWRCDGEDDCADNSDEENCENT 307
DG +C D + C +++ RC G C+ + S+RC A D CE+
Sbjct: 1315 DG-FECHDLDE--------CVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDGFFCEDR 1363
Query: 308 GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367
+CA + LC NG+C+ G C P ++ R + C N
Sbjct: 1364 D--ECAENVDLCDNGQCLN----APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG 1417
Query: 368 KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYEL 426
C+ + G +C C+ GY L G C D+NECA+ C G C N+ G++ C C +EL
Sbjct: 1418 SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
Query: 427 RPDRRSC 433
P C
Sbjct: 1478 NPSGVGC 1484
Score = 106 bits (264), Expect = 2e-22
Identities = 114/465 (24%), Positives = 162/465 (34%), Gaps = 61/465 (13%)
Query: 19 LASSPECACGR------SHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTC- 71
LA S C CG S C S G C + +C+ + E L
Sbjct: 783 LAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAW 842
Query: 72 -SP-----LDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEED--EFPCQNGYCI 123
SP +D C G CD N+CE S CP C F C+ C
Sbjct: 843 GSPCERCEIDPACARGFARMTGVTCDDVNECE--SFPGVCPNGRCVNTAGSFRCE---CP 897
Query: 124 RSLWHCDGDNDCGDNSDEQCDMRKCSDK-------EFRCSDGSC-IAEHW--YCDGDTDC 173
L C D E C +R D+ ++R C I W C+ D
Sbjct: 898 EGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDP 957
Query: 174 KDGSDEENCPSAV---------------PAPPCNLEEFQCAYGRC--ILDIYHCDGDDDC 216
+ CP + C + C +G C + +HC
Sbjct: 958 ESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGF 1017
Query: 217 GDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSD---ERNCT-TSMCTA 272
+ E +C+ CR +C G C+N + + +S +NC C
Sbjct: 1018 ALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECAR 1077
Query: 273 EQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKL 330
+ C G C S++C + CE+ +C+L LC +G+C+
Sbjct: 1078 DPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDID--ECSLSDGLCPHGQCVN---- 1131
Query: 331 CNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDG 390
G C ++ + + C V NGGC C G+ +C+C GY L DG
Sbjct: 1132 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG 1191
Query: 391 HTCQDVNECAEE-GYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
C DV+EC E C QG CTN G +C C G+ PD R+C
Sbjct: 1192 RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
Score = 87.8 bits (216), Expect = 9e-17
Identities = 113/461 (24%), Positives = 160/461 (34%), Gaps = 93/461 (20%)
Query: 14 LCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTC-- 71
LC HG + G H CA G + C ++C D C TC
Sbjct: 996 LCTHGTCRN---TVGSFHCACA----GGFALDAQERNCTDIDEC--RISPDLCGQGTCVN 1046
Query: 72 SPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDG 131
+P F C+ ++ +C D EC D C+ G C + DG
Sbjct: 1047 TPGSFECECFPGYESGFMLM--KNCMDVD--------ECARDPLLCRGGTCTNT----DG 1092
Query: 132 DNDCGDNSDEQC--------DMRKCSDKEFRCSDGSCI--AEHWYCDGDTDCKDGSDEEN 181
C + D+ +CS + C G C+ + C + D +
Sbjct: 1093 SYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQG 1152
Query: 182 CPSAVPAPPCNLEEFQCAYGRCILD--IYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
C V C ++ C CI Y C D C+ C +CD
Sbjct: 1153 C---VDINECRVQNGGCDV-HCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCD 1208
Query: 240 SGLCIN--AGWRC---DGDADCDDQS-----DERNCTTSMC-------TAEQFRCHS--G 280
G C N G RC DG D DE + +C T F CH G
Sbjct: 1209 QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLG 1268
Query: 281 RCVRL-SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRC----IGQRKLCNGVN 335
VR + C D+C NC++ S F C RC +G C+ ++
Sbjct: 1269 YMVRKGATGCSDVDECEVGG--HNCDSHASCLNIPGSFSC---RCLPGWVGDGFECHDLD 1323
Query: 336 DCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQD 395
+C S + C PR C V G+ +CTC G+ DG C+D
Sbjct: 1324 EC-----VSQEHRCSPRGD--------------CLNVPGSYRCTCRQGF--AGDGFFCED 1362
Query: 396 VNECAEE-GYCSQG-CTNSEGAFQCWCETGYELRPDRRSCK 434
+ECAE C G C N+ G ++C CE G++ D R+C+
Sbjct: 1363 RDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ 1403
Score = 82.4 bits (202), Expect = 4e-15
Identities = 125/518 (24%), Positives = 170/518 (32%), Gaps = 108/518 (20%)
Query: 11 GALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCI-LP 69
G L A G A C S C G+C + +QC D GC+ +
Sbjct: 1101 GHELTAKGTACEDIDECSLSDGLCPH---GQCVNVIGAFQCSCHAGFQSTPDRQGCVDIN 1157
Query: 70 TC----SPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPP-RECEEDEFPCQNGYCIR 124
C D HC N + S+ C D + C ECEE+ C G+C
Sbjct: 1158 ECRVQNGGCDVHCINTE---GSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCT- 1213
Query: 125 SLWHCDGDNDC--GDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCD-------------- 168
+ G + C D DMR C D + C I H C+
Sbjct: 1214 ---NMPGGHRCLCYDGFMATPDMRTCVDVD-ECDLNPHICLHGDCENTKGSFVCHCQLGY 1269
Query: 169 ----GDTDCKDGSDEE----NCPSAVPA------------PPCNLEEFQCA-YGRCILDI 207
G T C D + E NC S P + F+C C+
Sbjct: 1270 MVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQE 1329
Query: 208 YHCDGDDDC-------------GDWSDESDCSSHQPCRSGEFMCDSGLCINA--GWRCDG 252
+ C DC G D C C +CD+G C+NA G+RC+
Sbjct: 1330 HRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
Query: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLS--WRCDGEDDCADNSDEENCENTGSP 310
+ D D R C A+ C G C L +RC + NC T
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC--TDIN 1447
Query: 311 QCALDQFLCWNGRCIGQ--RKLCN-----GVNDCGDNSDESPQQNCRPRTGEEN------ 357
+CA D C NG CI LC+ +N G ++ NC T +
Sbjct: 1448 ECA-DPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISC 1506
Query: 358 --------------CNVNN--GGCAQKCQMVRGA---VQCTCHTGYRLTEDGHTCQDVNE 398
C++ G + C M C G++ +D++E
Sbjct: 1507 SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566
Query: 399 CAE-EGYCSQG-CTNSEGAFQCWCETGYELRPDRRSCK 434
C E G C G C N+ G+FQC C GY L R C+
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE 1604
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/217 (27%), Positives = 86/217 (39%), Gaps = 31/217 (14%)
Query: 231 CRSGEFMCDSGLCI----------NAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSG 280
CR +C +G C+ N G+ D +C D + CT+S C H G
Sbjct: 412 CRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDE---CTSSPC-------HHG 461
Query: 281 RCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCG 338
CV + ++ C + C + +C + LC GRC+ V C
Sbjct: 462 DCVNIPGTYHCRCYPGFQATPTRQACVDVD--ECIVSGGLCHLGRCVNTEGSFQCV--CN 517
Query: 339 DNSDESPQ-QNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVN 397
+ SP +NC C + C G+ C C G+ L GH C D++
Sbjct: 518 AGFELSPDGKNC---VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDID 574
Query: 398 ECAEEGYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
EC G C G CTN+EG+F+C C G + D R C
Sbjct: 575 ECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
Score = 79.7 bits (195), Expect = 2e-14
Identities = 113/466 (24%), Positives = 150/466 (32%), Gaps = 113/466 (24%)
Query: 10 LGALLCA---HGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC 66
L LLCA H S C C + A+ C DG DC E
Sbjct: 2172 LNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAM----CRDVDECADGQQDCHARGMECKN 2227
Query: 67 ILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSL 126
++ T + + C G R G+ C DD+ EC C NG C+ +
Sbjct: 2228 LIGTFACV---CPPGM---RPLPGSGEG-CTDDN--------ECHAQPDLCVNGRCVNTA 2272
Query: 127 --WHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAE--HWYCDGDTDCKDGSDEENC 182
+ CD C + + +C D G C AE C + + C
Sbjct: 2273 GSFRCD----CDEGFQPSPTLTECHD----IRQGPCFAEVLQTMCRSLSSSSEAVTRAEC 2324
Query: 183 PSA-----------VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPC 231
P P + C +G Y +G D DE C
Sbjct: 2325 CCGGGRGWGPRCELCPLPGTSAYRKLCPHGSG----YTAEGRD-----VDE--------C 2367
Query: 232 RSGEFMCDSGLCIN----------AGWRCDGDA----DCDDQSDERNCTTSMC--TAEQF 275
R +C G CIN AG+ D A D D+ S T +C T F
Sbjct: 2368 RMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSF 2427
Query: 276 RCHSGRCVRLSW---RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCN 332
C R L C D+C S + NC QFLC
Sbjct: 2428 LCSCPRGYLLEEDGRTCKDLDECT--SRQHNC-----------QFLC------------- 2461
Query: 333 GVNDCGDNSDESPQ---QNCRPRTGEENCNVNNGGCAQK--CQMVRGAVQCTCHTGYRLT 387
VN G + P Q+ + + C+ G C C G+ +C CH G+ L
Sbjct: 2462 -VNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2520
Query: 388 EDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSC 433
GH C+DVNEC C GC N G ++C C G+ C
Sbjct: 2521 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQC 2566
Score = 75.5 bits (184), Expect = 5e-13
Identities = 98/400 (24%), Positives = 150/400 (37%), Gaps = 92/400 (23%)
Query: 98 DDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCG-------DNSDEQC-DMRKCS 149
DDS E EC E+ C NG C+ + DG C D + C D +CS
Sbjct: 2079 DDSRED---VNECAENPGVCTNGVCVNT----DGSFRCECPFGYSLDFTGINCVDTDECS 2131
Query: 150 DKEFRCSDGSC--IAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCIL-- 205
C G+C + + C C DG + + C+L CA+ RC
Sbjct: 2132 VGH-PCGQGTCTNVIGGFECA----CADGFEPGLMMTCEDIDECSLNPLLCAF-RCHNTE 2185
Query: 206 ---------------DIYHCDGDDDCGDWSDESDCSSH-QPCRS--GEFMCDSGLCINAG 247
D C D+C D + DC + C++ G F C +C
Sbjct: 2186 GSYLCTCPAGYTLREDGAMCRDVDECAD--GQQDCHARGMECKNLIGTFAC---VCPPGM 2240
Query: 248 WRCDGDAD-CDDQSDERNCTTSMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENC 304
G + C D ++ C A+ C +GRCV S+RCD ++ + C
Sbjct: 2241 RPLPGSGEGCTDDNE--------CHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC 2292
Query: 305 ENTGSPQCALD--QFLCWN----GRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTG---- 354
+ C + Q +C + + + + C CG P+ P G
Sbjct: 2293 HDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC-----CGGGRGWGPRCELCPLPGTSAY 2347
Query: 355 EENCNVNNGGCAQ-----KCQMVR------------GAVQCTCHTGYRLTEDGHTCQDVN 397
+ C +G A+ +C+M+ G+ +C C GY TC D++
Sbjct: 2348 RKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD 2407
Query: 398 ECAEEGY-CSQGCTNSEGAFQCWCETGYELRPDRRSCKAL 436
EC++ C+ C N++G+F C C GY L D R+CK L
Sbjct: 2408 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDL 2447
Score = 73.6 bits (179), Expect = 2e-12
Identities = 52/179 (29%), Positives = 74/179 (41%), Gaps = 23/179 (12%)
Query: 264 NCTTSMCTAEQFRCHSGRCVRL--SWRCD-----GEDDCADNSDEENCENTGSPQCALDQ 316
N T +C C +GRC+ S+RC+ +D + D + C T SP
Sbjct: 406 NQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC--TSSP------ 457
Query: 317 FLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGC-AQKCQMVRGA 375
C +G C+ G C + + C V+ G C +C G+
Sbjct: 458 --CHHGDCVN----IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGS 511
Query: 376 VQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
QC C+ G+ L+ DG C D NECA C G C N +G+F C C+ G+ L P C
Sbjct: 512 FQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC 570
Score = 72.0 bits (175), Expect = 5e-12
Identities = 99/415 (23%), Positives = 148/415 (35%), Gaps = 70/415 (16%)
Query: 42 CTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFH-CDNGKCIRR--SWVCDGDNDCED 98
C C P + + DC D + C+ L C G C+ S+ C + E
Sbjct: 1870 CLCFPG-FVVTHNGDCVDFDE--------CTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
Query: 99 DSDEQDC-PPRECEEDEFPCQNGYC--IRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRC 155
+D ++C EC C G C + + C SD D+ +CS++ C
Sbjct: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1980
Query: 156 SDGSCIAE--HWYC---------DGDTDCKDGSDEENCPSAVPAPPCNLEE-FQCAYGRC 203
G+C + C D C D + + C + A C++ + F RC
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD-TRQSFCFTRFEAGKCSVPKAFNTTKTRC 2039
Query: 204 ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDER 263
+G W D + + + + +C G G D S E
Sbjct: 2040 CCSKRPGEG------WGDPCELCPQEGSAAFQELCPFG---------HGAVPGPDDSRE- 2083
Query: 264 NCTTSMCTAEQFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWN 321
+ C C +G CV S+RC+ + + NC +T C
Sbjct: 2084 --DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDE---------CSV 2132
Query: 322 GRCIGQRKLCNGVND----CGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQ 377
G GQ N + C D + C + C++N CA +C G+
Sbjct: 2133 GHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDI---DECSLNPLLCAFRCHNTEGSYL 2189
Query: 378 CTCHTGYRLTEDGHTCQDVNECAE-EGYC---SQGCTNSEGAFQCWCETGYELRP 428
CTC GY L EDG C+DV+ECA+ + C C N G F C C G +RP
Sbjct: 2190 CTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPG--MRP 2242
Score = 71.6 bits (174), Expect = 7e-12
Identities = 88/341 (25%), Positives = 123/341 (36%), Gaps = 71/341 (20%)
Query: 109 ECEEDEFPCQNGYCIRSL--WHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWY 166
EC E C NG CI + + C +C + + C D + C +
Sbjct: 1724 ECGEIPAICANGICINQIGSFRC----ECPAGFNYNSILLACEDVD------ECGSRESP 1773
Query: 167 CDGDTDCKD--GSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESD 224
C + DC + GS C P C +I + DC D
Sbjct: 1774 CQQNADCINIPGSYRCKCTRGYKLSPGG----ACVGRNECREIPNVCSHGDCMDTEGSYM 1829
Query: 225 CSSHQPCRSGEFMCDSGLCINAGWRCD----GDADCDDQSDERNCTTSMCTAEQFRCHSG 280
C H R + D LC++ CD G+ C + NC +C H+G
Sbjct: 1830 CLCH---RGFQASADQTLCMDID-ECDRQPCGNGTCKNIIGSYNC---LCFPGFVVTHNG 1882
Query: 281 RCVRLSWRCDGEDDCADNSDE----ENCENT-GSPQCALDQFLCWNG-RCIGQRKLCNGV 334
CV D+C + +C NT GS C LC +G K C
Sbjct: 1883 DCVDF-------DECTTLVGQVCRFGHCLNTAGSFHC-----LCQDGFELTADGKNCVDT 1930
Query: 335 NDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQ 394
N+C S C P T CQ + G+ +C C G+++ D C
Sbjct: 1931 NEC-----LSLAGTCLPGT---------------CQNLEGSFRCICPPGFQVQSD--HCI 1968
Query: 395 DVNECAEE-GYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
D++EC+EE C G CTNS G+FQC C G+ L + C
Sbjct: 1969 DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
Score = 69.7 bits (169), Expect = 3e-11
Identities = 109/457 (23%), Positives = 153/457 (33%), Gaps = 117/457 (25%)
Query: 51 CDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPP-RE 109
C DN+C H+ D C+ NG+C+ + G C+ D Q P E
Sbjct: 2250 CTDDNEC--HAQPDLCV------------NGRCVNTA----GSFRCDCDEGFQPSPTLTE 2291
Query: 110 CEE-DEFPC--------------QNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFR 154
C + + PC + R+ C G G E C + S
Sbjct: 2292 CHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRC-ELCPLPGTSAYRKL 2350
Query: 155 CSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDI----YHC 210
C GS G T +G D + C + CA+G CI + HC
Sbjct: 2351 CPHGS---------GYT--AEGRDVDEC---------RMLAHLCAHGECINSLGSFRCHC 2390
Query: 211 DG----DDDCGDWSDESDCSS-HQPCR------SGEFMCDS--GLCINAGWRCDGDADCD 257
D D +CS +PC G F+C G + R D D +
Sbjct: 2391 QAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLD-E 2449
Query: 258 DQSDERNCTTSMC--TAEQFRCHSGRC----VRLSWRCDGEDDCADNSD----EENCENT 307
S + NC +C T F C RC + C D+C+ +C NT
Sbjct: 2450 CTSRQHNCQF-LCVNTVGAFTC---RCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNT 2505
Query: 308 -GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCN------- 359
GS +C Q + C VN+C + Q C+ + G C+
Sbjct: 2506 PGSFRCECHQGFT----LVSSGHGCEDVNEC--DGPHRCQHGCQNQLGGYRCSCPQGFTQ 2559
Query: 360 -------VNNGGCA--------QKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECA-EEG 403
V+ CA C+ G +C C +G+ + CQ+V+ECA G
Sbjct: 2560 HSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRG 2619
Query: 404 YCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEP 440
CS C N+ G F C C GY LG P
Sbjct: 2620 PCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSP 2656
Score = 65.5 bits (158), Expect = 5e-10
Identities = 122/494 (24%), Positives = 166/494 (33%), Gaps = 113/494 (22%)
Query: 15 CAHGLASSPECACGRSHFTCAVSA----LGECTCIPAQWQC----------DGDNDCGDH 60
C G ++P C VS LG C +QC DG N C DH
Sbjct: 474 CYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKN-CVDH 532
Query: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN- 119
++ C T C NG C+ DG C P D CQ
Sbjct: 533 NE---CATSTM------CVNGVCLNE----DGSFSCLCKPGFLLAPGGHYCMDIDECQTP 579
Query: 120 GYCIRSLWHCDGDN-----DCGDNSDEQCDMRKCSDKEFRCS------DGSC-------I 161
G C+ HC C D R C D R + GSC +
Sbjct: 580 GICVNG--HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTV 637
Query: 162 AEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQ--CAYGRCILDIYHCDGDDDCGDW 219
+ C + D G + CP+ A EFQ C+ G I D
Sbjct: 638 TKSECCCANPDHGFGEPCQLCPAKDSA------EFQALCSSGLGITT-----------DG 680
Query: 220 SDESDCSSHQPCRSGEFMCDSGLCIN--AGWRCDGDADCDDQSDERNCT-TSMCTAEQFR 276
D ++C+ +C +G+C N +RC + + + ++CT C
Sbjct: 681 RDINECALDPE------VCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLL 734
Query: 277 CHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
C +G C S+ C D E C++ +C C +G C R L
Sbjct: 735 CDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVD--ECLSSP--CVSGVC---RNLAGSY 787
Query: 335 N-DCGDNSD---------ESPQQNCRPRTGEENCNVNNGGCA--QKCQMVRGA------- 375
CG S +S + C + E C VN G + +C GA
Sbjct: 788 TCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCE 847
Query: 376 ---VQCTCHTGY-RLTEDGHTCQDVNECAE-EGYCSQG-CTNSEGAFQCWCETGYELRPD 429
+ C G+ R+T G TC DVNEC G C G C N+ G+F+C C G L
Sbjct: 848 RCEIDPACARGFARMT--GVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDAS 905
Query: 430 RRSCKALGPEPVLL 443
R C + EP L
Sbjct: 906 GRLCVDVRLEPCFL 919
Score = 59.7 bits (143), Expect = 3e-08
Identities = 112/501 (22%), Positives = 162/501 (32%), Gaps = 131/501 (26%)
Query: 24 ECACGRSHFTCAVSALGECTCIPAQWQC------DGDNDCGDHSDEDGCILPTCSPLDFH 77
ECA G + A G C +P ++C + D G+ +D + C P +
Sbjct: 1407 ECAQGN------LCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPV------N 1454
Query: 78 CDNGKCIRR--SWVCDGDNDCEDDSDEQDC----------PPRECEEDEFPC--QNGYCI 123
C NG CI S++C D E + C + + C + G +
Sbjct: 1455 CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGV 1514
Query: 124 RSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE-ENC 182
C N E C M ++ C G E + + T + DE +
Sbjct: 1515 TRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGG----EGFQPNRITVILEDIDECQEL 1570
Query: 183 PSAVPAPPC--NLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS 240
P C FQC C + + C D +CS+H SG +C
Sbjct: 1571 PGLCQGGDCVNTFGSFQC---ECPPGYHLSEHTRIC---EDIDECSTH----SG--ICGP 1618
Query: 241 GLCINA--GWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC--------VRLSWRCD 290
G C N + C A+ + NC M + FR ++G C R C
Sbjct: 1619 GTCYNTLGNYTCVCPAEYLQVNGGNNCM-DMRKSVCFRHYNGTCQNELAFNVTRKMCCCS 1677
Query: 291 GEDDCADNSDEENCE----------------------NTGSP----QCALDQFLCWNGRC 324
A N E C +TG P +C +C NG C
Sbjct: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGIC 1737
Query: 325 IGQ-----------------RKLCNGVNDCGDNSDESP-QQN--CRPRTGEENCNVNNG- 363
I Q C V++CG S ESP QQN C G C G
Sbjct: 1738 INQIGSFRCECPAGFNYNSILLACEDVDECG--SRESPCQQNADCINIPGSYRCKCTRGY 1795
Query: 364 ------GCAQK--------------CQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEG 403
C + C G+ C CH G++ + D C D++EC +
Sbjct: 1796 KLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP 1855
Query: 404 YCSQGCTNSEGAFQCWCETGY 424
+ C N G++ C C G+
Sbjct: 1856 CGNGTCKNIIGSYNCLCFPGF 1876
Score = 43.5 bits (101), Expect = 0.002
Identities = 94/472 (19%), Positives = 148/472 (31%), Gaps = 116/472 (24%)
Query: 37 SALGECTCIPAQWQCD------GDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR--SW 88
S G+C +P ++C GD + DE C+ CDNG+C+ +
Sbjct: 1333 SPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDE-------CAENVDLCDNGQCLNAPGGY 1385
Query: 89 VCDGDNDCEDDSDEQDCPP-RECEEDEFPCQNGYC--IRSLWHC--DGDNDCGDNSDEQC 143
C+ + + D + C EC + C G C + ++ C +G +
Sbjct: 1386 RCECEMGFDPTEDHRACQDVDECAQGNL-CAFGSCENLPGMFRCICNGGYELDRGGGNCT 1444
Query: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRC 203
D+ +C+D C +G CI GS +CP P + G C
Sbjct: 1445 DINECADP-VNCINGVCINT-----------PGSYLCSCPQDFELNPSGVGCVDTRAGNC 1492
Query: 204 ILDIYH-------CDGDDDCGDWSDESDCS----------------------------SH 228
L+ + C + G CS
Sbjct: 1493 FLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF 1552
Query: 229 QP------------CRSGEFMCDSGLCINA--GWRCDGDADCDDQSDERNCTT-SMCTAE 273
QP C+ +C G C+N ++C+ R C C+
Sbjct: 1553 QPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTH 1612
Query: 274 QFRCHSGRCVRL--SWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ---- 327
C G C ++ C + + NC + C F +NG C +
Sbjct: 1613 SGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVC----FRHYNGTCQNELAFN 1668
Query: 328 --RKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ-KCQMVRGAVQCTCHTGY 384
RK+C C N ++ + C E C Q C HTG
Sbjct: 1669 VTRKMCC----CSYNIGQAWNRPC------EACPTPISPDYQILCGNQAPGFLTDIHTGK 1718
Query: 385 RLTEDGHTCQDVNECAE-EGYCSQG-CTNSEGAFQCWCETGYELRPDRRSCK 434
L D++EC E C+ G C N G+F+C C G+ +C+
Sbjct: 1719 PL--------DIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACE 1762
Score = 42.7 bits (99), Expect = 0.003
Identities = 41/144 (28%), Positives = 53/144 (36%), Gaps = 19/144 (13%)
Query: 308 GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN-CRPRTGEENCNVNNGGC- 365
G P C D+ GRCIG + G + + C + G E C G
Sbjct: 147 GQPIC--DRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLV 204
Query: 366 ---AQKCQMVRGA--VQCT--------CHTGYRLTEDGHTCQDVNEC-AEEGYCSQG-CT 410
A C V A + C C G+ CQDV+EC A G C G C
Sbjct: 205 CTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
Query: 411 NSEGAFQCWCETGYELRPDRRSCK 434
N G+F C C G+ L +C+
Sbjct: 265 NMVGSFHCRCPVGHRLSDSSAACE 288
Score = 40.4 bits (93), Expect = 0.017
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
DR + N+C +NGGC C+ + C+C G L DG+ C
Sbjct: 1149 DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC 1194
Score = 39.3 bits (90), Expect = 0.037
Identities = 15/35 (42%), Positives = 18/35 (51%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDG 1345
++C R G CS+ C P GF C CP G G G
Sbjct: 2612 DECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG 2646
Score = 37.0 bits (84), Expect = 0.18
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 1308 LGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
L ++C C+ LC F C+CP G L+ DG+TC
Sbjct: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 36.6 bits (83), Expect = 0.24
Identities = 13/39 (33%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCS 1044
C ++NGGC C+ + + C+C G +L+ DG+ C+
Sbjct: 1159 CRVQNGGCDVHCINTEG--SYRCSCGQGYSLMPDGRACA 1195
Score = 36.2 bits (82), Expect = 0.31
Identities = 29/103 (28%), Positives = 37/103 (35%), Gaps = 27/103 (26%)
Query: 359 NVNNGGC--AQKCQMVRGAVQ------------CTCHTGYRLTEDGHTCQDVNECA---- 400
N++ G C +CQ V G Q C C G+RL++ C+D A
Sbjct: 239 NIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSV 298
Query: 401 -EEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVL 442
G C+ QC C DR C A GP P L
Sbjct: 299 LFGGRCAGDLAGHYTRRQCCC--------DRGRCWAAGPVPEL 333
Score = 34.3 bits (77), Expect = 1.2
Identities = 41/201 (20%), Positives = 61/201 (30%), Gaps = 37/201 (18%)
Query: 79 DNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDN 138
DN +C + C C + C EC + +G+ + CDG + C
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRC---ECHQGFTLVSSGHGCEDVNECDGPHRCQHG 2541
Query: 139 SDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQC 198
Q +CS C G W C DE C A+ P C +
Sbjct: 2542 CQNQLGGYRCS-----CPQGFTQHSQW-----AQC---VDENEC--ALSPPTCGSASCRN 2586
Query: 199 AYG--RCILDIYHCDGDDDCGDWSDESDCSSHQ----------------PCRSGEFMCDS 240
G RC+ D D G + +C+ + C G F
Sbjct: 2587 TLGGFRCVCP-SGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQ 2645
Query: 241 GLCINAGWRCDGDADCDDQSD 261
G C++ G D D+ +
Sbjct: 2646 GHCVSGLGFSPGPQDTPDKEE 2666
Score = 33.1 bits (74), Expect = 2.7
Identities = 14/34 (41%), Positives = 17/34 (50%), Gaps = 2/34 (5%)
Query: 1317 NGGCSHL--CLPRPSGFSCACPTGIQLKGDGKTC 1348
+GG HL C+ F C C G +L DGK C
Sbjct: 496 SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529
Score = 32.3 bits (72), Expect = 4.5
Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 1311 NKCGSRNGGCSH-LCLPRPSGFSCACPTGIQLKGDGKTC 1348
N+C S G C + C+ F C CP G+ L G+ C
Sbjct: 871 NECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
Score = 32.0 bits (71), Expect = 5.9
Identities = 17/49 (34%), Positives = 21/49 (42%), Gaps = 6/49 (12%)
Query: 1607 SPQRQ--TGTNACGVNNGGCTHLCFARASDFVCACPD----EPDSRPCS 1649
+P RQ N C V NGGC C + C+C PD R C+
Sbjct: 1147 TPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA 1195
Score = 32.0 bits (71), Expect = 5.9
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKI-SSHACA 737
N C NGGC C+ + +Y C+C G+ + ACA
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA 1195
Score = 32.0 bits (71), Expect = 5.9
Identities = 29/101 (28%), Positives = 40/101 (39%), Gaps = 14/101 (13%)
Query: 1255 PYGLTLLDSYIYWTDWQTRSI-HRADKGTGSNVI------LVRSNLPGLMDMQAVDRAQP 1307
P+G +L + I D S+ H +GT +NVI PGLM M D
Sbjct: 2112 PFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-MTCED---- 2166
Query: 1308 LGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
++C C+ C + C CP G L+ DG C
Sbjct: 2167 --IDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205
Score = 32.0 bits (71), Expect = 5.9
Identities = 15/46 (32%), Positives = 19/46 (41%), Gaps = 4/46 (8%)
Query: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGI----QLKGDGKTCDPSP 1352
++C SR C LC+ F+C CP G Q D C P
Sbjct: 2448 DECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 108 bits (269), Expect = 7e-23
Identities = 92/327 (28%), Positives = 126/327 (38%), Gaps = 96/327 (29%)
Query: 69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC-----PP-----RECEEDEFPCQ 118
P C+ F C NGKCI +W C+ ++C D SDE+ C PP + C ++F C
Sbjct: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
Query: 119 NGY-----CIRSLWHCDGDNDCGDNSDE-QCDMRKCSD--------------KEFRCSDG 158
+ + C+ CDG+ DC D DE CD+ C +F
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
Query: 159 SCIAEHWYCD-GD--------TDCK-------------DGSDE-------------ENCP 183
+C W D GD TD K DG +E + P
Sbjct: 265 NCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
Query: 184 SAVPAPPCNLEEFQCA----YGRCILDIYHCDG-----DDDCGD----WSDESDCSSHQP 230
V + + CA R Y DG + CG ++++ C +
Sbjct: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 381
Query: 231 CRSG------------EFMCD-SGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC 277
C +G EF C +G+C RC+ C + SDE+NC C F C
Sbjct: 382 CPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHC 439
Query: 278 HSGRCVRLSWRCDGEDDCADNSDEENC 304
+ RCV SW CD +DDC D SDEENC
Sbjct: 440 KNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 92.4 bits (228), Expect = 4e-18
Identities = 47/119 (39%), Positives = 60/119 (50%), Gaps = 5/119 (4%)
Query: 71 CSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYCIRSLWH 128
C P + C N C CDG C + DE +C C+++EFPC +NG C
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
Query: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVP 187
C+ N C + SDE+ + C F C + C+ E W CD DC DGSDEENCP VP
Sbjct: 414 CNYQNHCPNGSDEK-NCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
Score = 80.9 bits (198), Expect = 1e-14
Identities = 52/150 (34%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 110 CEEDEFPCQNGY-CIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCS-DGSCIAEHWY 166
C E PC + C CDG C + DE C M C +EF CS +G C
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
Query: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
C+ C +GSDE+NC P F C RC+ + + CD DDCGD SDE +C
Sbjct: 414 CNYQNHCPNGSDEKNCFFCQPG------NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
Query: 227 SHQPCR------SGEFMCDSGLCINAGWRC 250
P R G +C L I G C
Sbjct: 468 VIVPTRVITAAVIGSLICGLLLVIALGCTC 497
Score = 78.6 bits (192), Expect = 6e-14
Identities = 46/121 (38%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 231 CRSGEFMCDSGL-CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWR 288
C E C C RCDG C + DE NCT MC E+F C +G C S R
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDR 413
Query: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN 348
C+ ++ C + SDE+NC C F C N RC+ + +C+ +DCGD SDE +N
Sbjct: 414 CNYQNHCPNGSDEKNCFF-----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE---EN 465
Query: 349 C 349
C
Sbjct: 466 C 466
Score = 77.8 bits (190), Expect = 9e-14
Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 6/92 (6%)
Query: 15 CAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPL 74
C +G + C + F C+ + + C P +C+ N C + SDE C C P
Sbjct: 382 CPNGRDETNCTMCQKEEFPCSRNGV----CYPRSDRCNYQNHCPNGSDEKNCFF--CQPG 435
Query: 75 DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP 106
+FHC N +C+ SWVCD +DC D SDE++CP
Sbjct: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
Score = 73.9 bits (180), Expect = 1e-12
Identities = 72/298 (24%), Positives = 108/298 (36%), Gaps = 86/298 (28%)
Query: 148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPPCNLEEFQC--- 198
C+ +FRC +G CI E W C+ +C D SDEE C P+A PC +FQC
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 199 --AYGRCILDIYHCDGDDDCGDWSDESDC----------------------SSHQPCRSG 234
C+ + CDG+ DC D DE DC + P +
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
Query: 235 EFMCDSG-----LCINAGWRCDGDADCD-------------------DQSDERNCTTSMC 270
++ D+G + ++ DG D D T +
Sbjct: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
Query: 271 TAEQFRCH-------SGRCVRLSWRCDG-----EDDCADN----SDEENCE--------- 305
++ Q R H + R +++ DG E C N ++++ C+
Sbjct: 327 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386
Query: 306 -NTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
T C ++F C NG C + CN N C + SDE C+P G +C N
Sbjct: 387 DETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQP--GNFHCKNN 442
Score = 60.5 bits (145), Expect = 2e-08
Identities = 38/108 (35%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 18 GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL----PT--- 70
G + P CAC + F C G CIP W+C+ ++CGD SDE+ C PT
Sbjct: 140 GKSEEPNCACDQ--FRC-----GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 192
Query: 71 ---CSPLDFHCDNG-----KCIRRSWVCDGDNDCEDDSDEQDCPPREC 110
C+ F C + C+ S CDG+ DC D DE DC C
Sbjct: 193 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
Score = 59.7 bits (143), Expect = 3e-08
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 227 SHQP-CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSM----------CTAEQF 275
S +P C +F C +G CI W+C+ +C D SDE C C QF
Sbjct: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
Query: 276 RCHSG-----RCVRLSWRCDGEDDCADNSDEENCE 305
+C S C+ S +CDG DC D DE +C+
Sbjct: 202 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
Score = 50.1 bits (118), Expect = 2e-05
Identities = 19/34 (55%), Positives = 25/34 (73%)
Query: 310 PQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
P CA DQF C NG+CI + CN +++CGD+SDE
Sbjct: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDE 178
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 108 bits (269), Expect = 7e-23
Identities = 92/327 (28%), Positives = 126/327 (38%), Gaps = 96/327 (29%)
Query: 69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC-----PP-----RECEEDEFPCQ 118
P C+ F C NGKCI +W C+ ++C D SDE+ C PP + C ++F C
Sbjct: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
Query: 119 NGY-----CIRSLWHCDGDNDCGDNSDE-QCDMRKCSD--------------KEFRCSDG 158
+ + C+ CDG+ DC D DE CD+ C +F
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
Query: 159 SCIAEHWYCD-GD--------TDCK-------------DGSDE-------------ENCP 183
+C W D GD TD K DG +E + P
Sbjct: 284 NCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
Query: 184 SAVPAPPCNLEEFQCA----YGRCILDIYHCDG-----DDDCGD----WSDESDCSSHQP 230
V + + CA R Y DG + CG ++++ C +
Sbjct: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 400
Query: 231 CRSG------------EFMCD-SGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC 277
C +G EF C +G+C RC+ C + SDE+NC C F C
Sbjct: 401 CPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHC 458
Query: 278 HSGRCVRLSWRCDGEDDCADNSDEENC 304
+ RCV SW CD +DDC D SDEENC
Sbjct: 459 KNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 92.4 bits (228), Expect = 4e-18
Identities = 47/119 (39%), Positives = 60/119 (50%), Gaps = 5/119 (4%)
Query: 71 CSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYCIRSLWH 128
C P + C N C CDG C + DE +C C+++EFPC +NG C
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
Query: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVP 187
C+ N C + SDE+ + C F C + C+ E W CD DC DGSDEENCP VP
Sbjct: 433 CNYQNHCPNGSDEK-NCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 80.9 bits (198), Expect = 1e-14
Identities = 52/150 (34%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 110 CEEDEFPCQNGY-CIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCS-DGSCIAEHWY 166
C E PC + C CDG C + DE C M C +EF CS +G C
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
Query: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
C+ C +GSDE+NC P F C RC+ + + CD DDCGD SDE +C
Sbjct: 433 CNYQNHCPNGSDEKNCFFCQPG------NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
Query: 227 SHQPCR------SGEFMCDSGLCINAGWRC 250
P R G +C L I G C
Sbjct: 487 VIVPTRVITAAVIGSLICGLLLVIALGCTC 516
Score = 78.6 bits (192), Expect = 6e-14
Identities = 46/121 (38%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 231 CRSGEFMCDSGL-CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWR 288
C E C C RCDG C + DE NCT MC E+F C +G C S R
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDR 432
Query: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN 348
C+ ++ C + SDE+NC C F C N RC+ + +C+ +DCGD SDE +N
Sbjct: 433 CNYQNHCPNGSDEKNCFF-----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE---EN 484
Query: 349 C 349
C
Sbjct: 485 C 485
Score = 77.8 bits (190), Expect = 9e-14
Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 6/92 (6%)
Query: 15 CAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPL 74
C +G + C + F C+ + + C P +C+ N C + SDE C C P
Sbjct: 401 CPNGRDETNCTMCQKEEFPCSRNGV----CYPRSDRCNYQNHCPNGSDEKNCFF--CQPG 454
Query: 75 DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP 106
+FHC N +C+ SWVCD +DC D SDE++CP
Sbjct: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
Score = 73.9 bits (180), Expect = 1e-12
Identities = 72/298 (24%), Positives = 108/298 (36%), Gaps = 86/298 (28%)
Query: 148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPPCNLEEFQC--- 198
C+ +FRC +G CI E W C+ +C D SDEE C P+A PC +FQC
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 199 --AYGRCILDIYHCDGDDDCGDWSDESDC----------------------SSHQPCRSG 234
C+ + CDG+ DC D DE DC + P +
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
Query: 235 EFMCDSG-----LCINAGWRCDGDADCD-------------------DQSDERNCTTSMC 270
++ D+G + ++ DG D D T +
Sbjct: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
Query: 271 TAEQFRCH-------SGRCVRLSWRCDG-----EDDCADN----SDEENCE--------- 305
++ Q R H + R +++ DG E C N ++++ C+
Sbjct: 346 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 405
Query: 306 -NTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
T C ++F C NG C + CN N C + SDE C+P G +C N
Sbjct: 406 DETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQP--GNFHCKNN 461
Score = 60.5 bits (145), Expect = 2e-08
Identities = 38/108 (35%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 18 GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL----PT--- 70
G + P CAC + F C G CIP W+C+ ++CGD SDE+ C PT
Sbjct: 159 GKSEEPNCACDQ--FRC-----GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 211
Query: 71 ---CSPLDFHCDNG-----KCIRRSWVCDGDNDCEDDSDEQDCPPREC 110
C+ F C + C+ S CDG+ DC D DE DC C
Sbjct: 212 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
Score = 59.7 bits (143), Expect = 3e-08
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 227 SHQP-CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSM----------CTAEQF 275
S +P C +F C +G CI W+C+ +C D SDE C C QF
Sbjct: 161 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
Query: 276 RCHSG-----RCVRLSWRCDGEDDCADNSDEENCE 305
+C S C+ S +CDG DC D DE +C+
Sbjct: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
Score = 50.1 bits (118), Expect = 2e-05
Identities = 19/34 (55%), Positives = 25/34 (73%)
Query: 310 PQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
P CA DQF C NG+CI + CN +++CGD+SDE
Sbjct: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDE 197
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 107 bits (266), Expect = 1e-22
Identities = 107/436 (24%), Positives = 164/436 (37%), Gaps = 72/436 (16%)
Query: 36 VSALGECTCIPAQWQCDGDNDCGDHSDEDGCI-LPTCSPLDFHCDNGKC--IRRSWVCDG 92
+ G C +P ++ C + C+ + C+ + C G+C S++C
Sbjct: 884 ICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCIC 943
Query: 93 DNDCEDDSDEQDC-PPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDK 151
+ +C EC + C G+C+ N G E CD +
Sbjct: 944 PAGFMASEEGTNCIDVDECLRPDV-CGEGHCV---------NTVGAFRCEYCDSGYRMTQ 993
Query: 152 EFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCD 211
RC D I E C + C D N P + PC E F+ G+C LD+ C
Sbjct: 994 RGRCED---IDE---CLNPSTCPD-EQCVNSPGSYQCVPCT-EGFRGWNGQC-LDVDECL 1044
Query: 212 GDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERN---CTTS 268
+ C + DCS+ + G +MC C R C D + + C
Sbjct: 1045 EPNVCAN----GDCSNLE----GSYMCS---CHKGYTRTPDHKHCRDIDECQQGNLCVNG 1093
Query: 269 MC--TAEQFRCHSGRCVRLSW---RCDGEDDCADNS--DEENCENT-GSPQCALDQFLCW 320
C T FRC G+ +LS +C+ D+C C NT GS QC DQ
Sbjct: 1094 QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQ---- 1149
Query: 321 NGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNG----------------- 363
R G C +N+C ++ + +C G +C +G
Sbjct: 1150 GYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEH 1209
Query: 364 ----GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYC-SQG-CTNSEGAFQ 417
G +C G+ C C G+ ++ DG TC+D++EC C S G C N+ G+F+
Sbjct: 1210 PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFR 1269
Query: 418 CWCETGYELRPDRRSC 433
C C G++ D + C
Sbjct: 1270 CLCYQGFQAPQDGQGC 1285
Score = 91.7 bits (226), Expect = 6e-18
Identities = 74/275 (26%), Positives = 109/275 (39%), Gaps = 42/275 (15%)
Query: 191 CNLEEFQCAYGRCI-LDI-YHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA-- 246
C + C G CI L + Y C + + C C + +C G C N
Sbjct: 878 CTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEG 937
Query: 247 ---------------GWRCDGDADC--DDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRC 289
G C +C D E +C ++ C SG + RC
Sbjct: 938 SFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 997
Query: 290 DGEDDCADNSD--EENCENT-GSPQCA--LDQFLCWNGRCIGQRKLCNGVNDC--GDNSD 342
+ D+C + S +E C N+ GS QC + F WNG+C+ + C N C GD S+
Sbjct: 998 EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDE-CLEPNVCANGDCSN 1056
Query: 343 ESPQQNCRPRTGE------------ENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDG 390
C G + C N +C+ G+ +CTC GY+L+
Sbjct: 1057 LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAK 1116
Query: 391 HTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGY 424
C+D++EC C+ G C N+EG+FQC C+ GY
Sbjct: 1117 DQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGY 1151
Score = 84.7 bits (208), Expect = 8e-16
Identities = 94/363 (25%), Positives = 141/363 (38%), Gaps = 74/363 (20%)
Query: 109 ECEEDEFPCQNGYCI----RSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEH 164
EC + C G+CI R C + + D+ +C+ + CS G C
Sbjct: 877 ECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC---- 932
Query: 165 WYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESD 224
+ +GS CP+ A EE G +D+ C D CG E
Sbjct: 933 -------ENTEGSFLCICPAGFMAS----EE-----GTNCIDVDECLRPDVCG----EGH 972
Query: 225 CSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSD--ERNCTTSM-------CTAEQF 275
C + E+ CDSG + RC+ +C + S + C S CT E F
Sbjct: 973 CVNTVGAFRCEY-CDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCT-EGF 1030
Query: 276 RCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRC-IGQRKLCNGV 334
R +G+C+ + C + CA N D N E GS C+ C G K C +
Sbjct: 1031 RGWNGQCLDVD-ECLEPNVCA-NGDCSNLE--GSYMCS-----CHKGYTRTPDHKHCRDI 1081
Query: 335 NDCGDNSDESPQQNCRPRTGEENCNVNNGG--------------------CAQ-KCQMVR 373
++C + C+ G C G CA +C+
Sbjct: 1082 DEC-QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTE 1140
Query: 374 GAVQCTCHTGYRLTEDGHTCQDVNECAEE-GYCSQG-CTNSEGAFQCWCETGYELRPDRR 431
G+ QC C GYR + G C+D+NEC E+ C +G C N+ G++ C C G++L D +
Sbjct: 1141 GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNK 1199
Query: 432 SCK 434
+C+
Sbjct: 1200 TCQ 1202
Score = 68.9 bits (167), Expect = 4e-11
Identities = 103/476 (21%), Positives = 162/476 (34%), Gaps = 113/476 (23%)
Query: 14 LCAHGLASSPE----CACGRSHFTCAVS---------------ALGECTCIPAQWQCDGD 54
LC +G + E C CG+ + A A G+C +QC D
Sbjct: 1089 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCD 1148
Query: 55 -----NDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSW----VCDGDNDCEDDSDEQDC 105
+ GDH ++ + C C G CI + C +D+ QD
Sbjct: 1149 QGYRASGLGDHCED----INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI 1204
Query: 106 PPRECEEDEFPCQNGYCIRS--LWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAE 163
ECE G C+ + +HC C D R C D + C + +
Sbjct: 1205 --NECEHPGLCGPQGECLNTEGSFHCV----CQQGFSISADGRTCEDID-ECVNNTVCDS 1257
Query: 164 HWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDG-DDDCGDWSDE 222
H +CD GS C AP G+ +D+ C+ CG E
Sbjct: 1258 HGFCDNTA----GSFRCLCYQGFQAPQD---------GQGCVDVNECELLSGVCG----E 1300
Query: 223 SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282
+ C + + G F+C C D++ E + T C + R +
Sbjct: 1301 AFCENVE----GSFLCV----------------CADENQEYSPMTGQCRS---RTSTDLD 1337
Query: 283 VRLSWRCDGEDDCADN-SDEENCENTGSPQCALDQFLCWNGRCIGQR------------- 328
V + + + +C N +D C+N +P + C +G G
Sbjct: 1338 VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1397
Query: 329 --KLC---NGVNDCGDNSDESPQQNCRPRT-----GEENCNVNNGGCAQKCQMVRGAVQC 378
++C G G++S E+ +N + G+E C NG C R +C
Sbjct: 1398 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK--NGFCLN----TRPGYEC 1451
Query: 379 TCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYELRPDRRSC 433
C G C D++EC + C G C N+EG++ C+C L + C
Sbjct: 1452 YCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1507
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/527 (21%), Positives = 170/527 (32%), Gaps = 158/527 (29%)
Query: 41 ECTCIPAQWQCDGDNDCGDHSDEDGCILP-TCSPL--------DFHC------------- 78
+CTC P +Q D + C D ++ C P C P FHC
Sbjct: 1186 DCTC-PDGFQLDDNKTCQDINE---CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGR 1241
Query: 79 ---DNGKCIRRSWVCDGDNDCEDDS---------------DEQDCPP-RECEEDEFPCQN 119
D +C+ + VCD C++ + D Q C ECE C
Sbjct: 1242 TCEDIDECVNNT-VCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE 1300
Query: 120 GYC--IRSLWHCDGDNDCGDNSDE------QCDMRKCSDKEFRCSDGSCIAEHWY----- 166
+C + + C C D + E QC R +D + + Y
Sbjct: 1301 AFCENVEGSFLCV----CADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLND 1356
Query: 167 ---CDG---------DTDCKDGSD-EENCPSAVPAPPCNLEEF--QCAYGRCILDIYHCD 211
CD + C G+ +NC P P EF C G+ +
Sbjct: 1357 ASLCDNVLAPNVTKQECCCTSGAGWGDNC-EIFPCPVLGTAEFTEMCPKGKGFVPAGESS 1415
Query: 212 GDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA--GWRCDGDA------------DCD 257
+ ++ D +C G+ +C +G C+N G+ C D D
Sbjct: 1416 SEAGGENYKDADECLLF-----GQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMD 1470
Query: 258 DQSDERNCTTSMC--TAEQFRCH----------SGRCVRLSWRCDG-------EDDCADN 298
+ D +C C T + C RC+R + + +D C ++
Sbjct: 1471 ECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEH 1530
Query: 299 -SDEENC------ENTGSPQCALDQFLCWNGRCI--------GQRKLCN----------G 333
SDE C + T +C W +C +LCN G
Sbjct: 1531 LSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYG 1590
Query: 334 VNDCGDNSDESPQQ-----------NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHT 382
+ D S++ + N E C + NG +C V+ C C
Sbjct: 1591 RDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFD 1650
Query: 383 GYRLTEDGHTCQDVNECAE----EGYCSQG-CTNSEGAFQCWCETGY 424
GY L TC DVNEC E C C N++G+++C C GY
Sbjct: 1651 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697
Score = 47.0 bits (110), Expect = 2e-04
Identities = 23/65 (35%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 380 CHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYELRPDRRSCKALGP 438
C GY+ + CQD+NEC +G C G C N+ G+++C C+ G+ P SC P
Sbjct: 612 CLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV---P 667
Query: 439 EPVLL 443
+P ++
Sbjct: 668 DPPVI 672
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,268,335
Number of Sequences: 37866
Number of extensions: 4302500
Number of successful extensions: 19451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 10542
Number of HSP's gapped (non-prelim): 3704
length of query: 1905
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1788
effective length of database: 13,817,196
effective search space: 24705146448
effective search space used: 24705146448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.