Guide to the Human Genome
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Name: LDLR Sequence: fasta or formatted (860aa) NCBI GI: 4504975
Description:

low density lipoprotein receptor precursor

Referenced in:

Major Disease Loci
Epidermal Growth Factor
Lipoproteins
Additional Membrane Functions

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.0         43           3
 C cysteine            7.3         63           1
 D aspartate           8.7         75           2
 E glutamate           5.6         48           2
 F phenylalanine       3.0         26           2
 G glycine             7.2         62           2
 H histidine           2.2         19           1
 I isoleucine          4.2         36           2
 K lysine              4.2         36           2
 L leucine             7.7         66           3
 M methionine          1.3         11           1
 N asparagine          4.8         41           2
 P proline             4.5         39           2
 Q glutamine           4.0         34           1
 R arginine            5.3         46           2
 S serine              8.1         70           2
 T threonine           5.8         50           3
 V valine              6.7         58           2
 W tryptophan          2.3         20           1
 Y tyrosine            2.0         17           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   low density lipoprotein receptor precursor 
VLDLR                 0.488   very low density lipoprotein receptor isoform a [Hom...
VLDLR                 0.471   very low density lipoprotein receptor isoform b [Hom...
LRP8                  0.437   low density lipoprotein receptor-related protein 8 i...
LRP8                  0.431   low density lipoprotein receptor-related protein 8 i...
LRP8                  0.371   low density lipoprotein receptor-related protein 8 i...
LRP8                  0.362   low density lipoprotein receptor-related protein 8 i...
LRP4                  0.293   low density lipoprotein receptor-related protein 4 ...
LRP1                  0.263   low density lipoprotein-related protein 1 
LRP1B                 0.257   low density lipoprotein-related protein 1B precursor...
LRP2                  0.254   low density lipoprotein-related protein 2 
LRP6                  0.113   low density lipoprotein receptor-related protein 6 ...
EGF                   0.112   epidermal growth factor (beta-urogastrone) 
SORL1                 0.112   sortilin-related receptor containing LDLR class A rep...
LRP5                  0.112   low density lipoprotein receptor-related protein 5 ...
SSPO                  0.094   SCO-spondin 
NID1                  0.065   nidogen 1 precursor 
CORIN                 0.062   corin 
HSPG2                 0.058   heparan sulfate proteoglycan 2 
NID2                  0.057   nidogen 2 precursor 
ST14                  0.057   matriptase 
LRP5L                 0.055   low density lipoprotein receptor-related protein 5-l...
LRP5L                 0.055   low density lipoprotein receptor-related protein 5-...
FBN2                  0.042   fibrillin 2 precursor 
MEGF6                 0.041   EGF-like-domain, multiple 3 
SCUBE1                0.041   signal peptide, CUB domain, EGF-like 1 
LDLRAD3               0.041   low density lipoprotein receptor class A domain cont...
LTBP1                 0.041   latent transforming growth factor beta binding prote...
LTBP1                 0.041   latent transforming growth factor beta binding prote...
LRP3                  0.039   low density lipoprotein receptor-related protein 3 ...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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