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Search of human proteins with 156564401
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156564401 vesicle-fusing ATPase [Homo sapiens]
(744 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156564401 vesicle-fusing ATPase [Homo sapiens] 1460 0.0
gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive fa... 961 0.0
gi|239740963 PREDICTED: similar to N-ethylmaleimide-sensitive fa... 494 e-139
gi|6005942 valosin-containing protein [Homo sapiens] 189 8e-48
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 167 4e-41
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 150 4e-36
gi|4505725 peroxin1 [Homo sapiens] 149 1e-35
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens] 147 5e-35
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 146 8e-35
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens] 146 8e-35
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 145 1e-34
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 139 1e-32
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 134 2e-31
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 134 2e-31
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ... 134 4e-31
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi... 134 4e-31
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 134 4e-31
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 132 9e-31
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 130 3e-30
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 130 6e-30
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens] 129 1e-29
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 114 3e-25
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 113 6e-25
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 113 6e-25
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens] 113 6e-25
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens] 113 6e-25
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens] 112 2e-24
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens] 112 2e-24
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap... 112 2e-24
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 106 7e-23
>gi|156564401 vesicle-fusing ATPase [Homo sapiens]
Length = 744
Score = 1460 bits (3780), Expect = 0.0
Identities = 744/744 (100%), Positives = 744/744 (100%)
Query: 1 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 60
MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI
Sbjct: 1 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 60
Query: 61 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 120
AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE
Sbjct: 61 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 120
Query: 121 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 180
FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN
Sbjct: 121 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 180
Query: 181 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 240
SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF
Sbjct: 181 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 240
Query: 241 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA 300
PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA
Sbjct: 241 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA 300
Query: 301 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG 360
NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG
Sbjct: 301 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG 360
Query: 361 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL 420
VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL
Sbjct: 361 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL 420
Query: 421 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF 480
SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF
Sbjct: 421 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF 480
Query: 481 LASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVL 540
LASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVL
Sbjct: 481 LASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVL 540
Query: 541 LEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCV 600
LEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCV
Sbjct: 541 LEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCV 600
Query: 601 VVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNA 660
VVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNA
Sbjct: 601 VVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNA 660
Query: 661 FSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQM 720
FSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQM
Sbjct: 661 FSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQM 720
Query: 721 DPEYRVRKFLALLREEGASPLDFD 744
DPEYRVRKFLALLREEGASPLDFD
Sbjct: 721 DPEYRVRKFLALLREEGASPLDFD 744
>gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive
factor [Homo sapiens]
Length = 563
Score = 961 bits (2484), Expect = 0.0
Identities = 488/490 (99%), Positives = 489/490 (99%)
Query: 1 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 60
MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI
Sbjct: 74 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 133
Query: 61 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 120
AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE
Sbjct: 134 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 193
Query: 121 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 180
FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN
Sbjct: 194 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 253
Query: 181 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 240
SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF
Sbjct: 254 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 313
Query: 241 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA 300
PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA
Sbjct: 314 PPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA 373
Query: 301 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG 360
NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG
Sbjct: 374 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDG 433
Query: 361 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL 420
+EQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL
Sbjct: 434 MEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLL 493
Query: 421 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDF 480
SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQV RGDF
Sbjct: 494 SADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVMRGDF 553
Query: 481 LASLENDIKP 490
LASLENDIKP
Sbjct: 554 LASLENDIKP 563
Score = 36.6 bits (83), Expect = 0.087
Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 18/130 (13%)
Query: 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSP----DKMIGFSETAKCQAMKKIFDDAYK 594
+LL GPP GKT LA +I + N K+ + +K +G SE ++K+F DA +
Sbjct: 329 ILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEA----NIRKLFADAEE 384
Query: 595 SQ--------LSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKK--APPQGRKLLIIG 644
Q L ++ D+I+ + + + + LL K Q +L+IG
Sbjct: 385 EQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGMEQLNNILVIG 444
Query: 645 TTSRKDVLQE 654
T+R D++ E
Sbjct: 445 MTNRPDLIDE 454
>gi|239740963 PREDICTED: similar to N-ethylmaleimide-sensitive
factor [Homo sapiens]
Length = 405
Score = 494 bits (1272), Expect = e-139
Identities = 248/248 (100%), Positives = 248/248 (100%)
Query: 1 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 60
MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI
Sbjct: 74 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSI 133
Query: 61 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 120
AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE
Sbjct: 134 AFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAE 193
Query: 121 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 180
FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN
Sbjct: 194 FIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGN 253
Query: 181 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 240
SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF
Sbjct: 254 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVF 313
Query: 241 PPEIVEQM 248
PPEIVEQM
Sbjct: 314 PPEIVEQM 321
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 189 bits (480), Expect = 8e-48
Identities = 148/446 (33%), Positives = 229/446 (51%), Gaps = 35/446 (7%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
IGG K+ + I + + P + + +G K +GILLYGPPG GKTL+AR + A
Sbjct: 206 IGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGA 264
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
++NGPEI++K GESE+N+RK F +AE+ II DE+DAI +R
Sbjct: 265 FF-FLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREK 315
Query: 340 MAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPD 399
G V +V+QLL+ +DG++Q +++V+ TNRP+ ID AL R GR + +++IG+PD
Sbjct: 316 THGE--VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPD 373
Query: 400 EKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
GRL+IL IHT M+ L+ DVD++++A ET GA+L L A A+ + +
Sbjct: 374 ATGRLEILQIHTKNMK----LADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDL 429
Query: 460 STKVE--VDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRV 517
+ +D E SL VT DF +L A + I D V R
Sbjct: 430 IDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLED-VKRE 488
Query: 518 LDDGELLVQQTKNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD 571
L EL+ ++ D+ TP VL GPP GKT LA IA E FI I P+
Sbjct: 489 LQ--ELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPE 546
Query: 572 KM-IGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLL----DYVPIGPRFSNLVLQAL 626
+ + F E+ +++IFD A ++ + D+++ + + G ++ V+ +
Sbjct: 547 LLTMWFGESE--ANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQI 604
Query: 627 LVLLKKAPPQGRKLLIIGTTSRKDVL 652
L + + + + IIG T+R D++
Sbjct: 605 LTEMDGMSTK-KNVFIIGATNRPDII 629
Score = 160 bits (404), Expect = 5e-39
Identities = 100/273 (36%), Positives = 152/273 (55%), Gaps = 22/273 (8%)
Query: 220 IGGLDKEFSDIFRRAFASRVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKM 276
IGGL+ D+ R +P P+ + G KG+L YGPPGCGKTLLA+ I
Sbjct: 479 IGGLE----DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANE 534
Query: 277 LNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQ 336
A + GPE+L + GESEAN+R++F A + + ++ FDE+D+I K
Sbjct: 535 CQANFISI-KGPELLTMWFGESEANVREIFDKARQ--------AAPCVLFFDELDSIAKA 585
Query: 337 RGSMAGSTG-VHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEI 395
RG G G D V+NQ+L+++DG+ N+ +IG TNRPD+ID A+LRPGRL+ + I
Sbjct: 586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645
Query: 396 GLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR 455
LPDEK R+ IL + + ++ DVD++ LA T FSGA+L + + A A+
Sbjct: 646 PLPDEKSRVAILKANLRK----SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRE 701
Query: 456 HIKASTKVEVDME-KAESLQVTRGDFLASLEND 487
I++ + E + + +++V D + + D
Sbjct: 702 SIESEIRRERERQTNPSAMEVEEDDPVPEIRRD 734
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 167 bits (422), Expect = 4e-41
Identities = 141/457 (30%), Positives = 226/457 (49%), Gaps = 47/457 (10%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
IGGL + I R + PE+ + G +G+LLYGPPG GKT++AR + + A
Sbjct: 355 IGGLSSQLKAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGA 413
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
V+NGPEI++K+ GE+EA +R++FA+A II DE+DA+C +R
Sbjct: 414 YV-SVINGPEIISKFYGETEAKLRQIFAEATLRHPS--------IIFIDELDALCPKREG 464
Query: 340 MAGSTGVHDTVVNQLLSKIDGVEQL---NNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396
V VV LL+ +DG+ +LV+G TNRP +D AL RPGR + ++EIG
Sbjct: 465 AQNE--VEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIG 522
Query: 397 LPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH 456
+P+ + RL IL +R L + ++ +LA + GA+L+ L A A+ R
Sbjct: 523 VPNAQDRLDILQ---KLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRI 579
Query: 457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTR 516
+K + D++ A +++T DFL ++ NDI+P + + A + N + W D
Sbjct: 580 LKKQPNLP-DVKVAGLVKITLKDFLQAM-NDIRP---SAMREIAIDVPN--VSWSD--IG 630
Query: 517 VLDDGELLVQQT-----KNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFPFI 565
L+ +L ++Q K+ + P VLL GPP KT +A +A ES F+
Sbjct: 631 GLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFL 690
Query: 566 KICSPD---KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLV 622
I P+ K +G SE +A+++ F A S + D+++ L N+
Sbjct: 691 AIKGPELMNKYVGESE----RAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVA 746
Query: 623 LQALLVLLKKAP--PQGRKLLIIGTTSRKDVLQEMEM 657
+ L LL + Q + + I+ T+R D + + M
Sbjct: 747 DRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALM 783
Score = 159 bits (401), Expect = 1e-38
Identities = 100/269 (37%), Positives = 155/269 (57%), Gaps = 18/269 (6%)
Query: 192 SLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCK 251
++N I + +E + N W+ IGGL+ + +A + PE +MG +
Sbjct: 605 AMNDIRPSAMREIAIDVPNVSWS----DIGGLESIKLKL-EQAVEWPLKHPESFIRMGIQ 659
Query: 252 HVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEE 311
KG+LLYGPPGC KT++A+ + + + GPE++NKYVGESE +R+ F A
Sbjct: 660 PPKGVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNKYVGESERAVRETFRKA-- 716
Query: 312 EQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIG 371
R A S II FDE+DA+ +RGS G+ V D V+ QLL+++DG+EQL ++ ++
Sbjct: 717 ---RAVAPS---IIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA 770
Query: 372 MTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAV 431
TNRPD ID+AL+RPGR++ + + LPD R +I + M +S +VD+ EL +
Sbjct: 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMP----VSNEVDLDELIL 826
Query: 432 ETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
+T +SGAE+ + R A A+ I+A+
Sbjct: 827 QTDAYSGAEIVAVCREAALLALEEDIQAN 855
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 150 bits (379), Expect = 4e-36
Identities = 99/266 (37%), Positives = 149/266 (56%), Gaps = 19/266 (7%)
Query: 211 PDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLA 270
PD +E IGGLDK+ +I + V PE+ E +G KG+LLYGPPG GKTLLA
Sbjct: 144 PDSTYEM--IGGLDKQIKEI-KEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLA 200
Query: 271 RQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEI 330
R + + +V +G E++ K++GE +R+LF A E II DEI
Sbjct: 201 RAVAHHTDCTFIRV-SGSELVQKFIGEGARMVRELFVMAREHAPS--------IIFMDEI 251
Query: 331 DAICKQR--GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGR 388
D+I R G G + V T++ +LL+++DG E NI VI TNR D++D ALLRPGR
Sbjct: 252 DSIGSSRLEGGSGGDSEVQRTML-ELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGR 310
Query: 389 LEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAA 448
++ K+E P+E+ RL IL IH+ +M L+ ++++++A SGAE++G+ A
Sbjct: 311 IDRKIEFPPPNEEARLDILKIHSRKMN----LTRGINLRKIAELMPGASGAEVKGVCTEA 366
Query: 449 QSTAMNRHIKASTKVEVDMEKAESLQ 474
A+ T+ + +M A+ +Q
Sbjct: 367 GMYALRERRVHVTQEDFEMAVAKVMQ 392
Score = 35.8 bits (81), Expect = 0.15
Identities = 32/120 (26%), Positives = 60/120 (50%), Gaps = 10/120 (8%)
Query: 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDDAYKS 595
VLL GPP +GKT LA +A ++ FI++ + K IG + ++++F A +
Sbjct: 186 VLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIG----EGARMVRELFVMAREH 241
Query: 596 QLSCVVVDDIERL-LDYVPIGPRFSNLVLQALLVLLKKAP--PQGRKLLIIGTTSRKDVL 652
S + +D+I+ + + G + V + +L LL + + + +I T+R D+L
Sbjct: 242 APSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDIL 301
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 149 bits (375), Expect = 1e-35
Identities = 93/223 (41%), Positives = 137/223 (61%), Gaps = 23/223 (10%)
Query: 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGE 297
PE+ + + GILLYGPPG GKTLLA I ARE ++ V GPE+L+KY+G
Sbjct: 863 PELFANLPIRQRTGILLYGPPGTGKTLLAGVI-----ARESRMNFISVKGPELLSKYIGA 917
Query: 298 SEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK 357
SE +R +F A+ + I+ FDE ++I +RG +TGV D VVNQLL++
Sbjct: 918 SEQAVRDIFIRAQAAKPC--------ILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQ 967
Query: 358 IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH 417
+DGVE L + V+ T+RPDLID ALLRPGRL+ + PD+ RL+IL++ + +
Sbjct: 968 LDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLP-- 1025
Query: 418 QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
L+ DVD++ +A T +F+GA+L+ L+ AQ A++ + +S
Sbjct: 1026 --LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSS 1066
Score = 47.8 bits (112), Expect = 4e-05
Identities = 56/195 (28%), Positives = 90/195 (46%), Gaps = 24/195 (12%)
Query: 423 DVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLA 482
D+D++ +A ET F + LV A + ++R ST+ ++ + + + RG A
Sbjct: 766 DLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQ-SISTREKLVLTTLDFQKALRGFLPA 824
Query: 483 SLE--NDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDG-ELLVQQTKNSDRTPL--- 536
SL N KP D + G+ + V ++L D +L + + P+
Sbjct: 825 SLRSVNLHKP------RDLGWDKIGGLHE----VRQILMDTIQLPAKYPELFANLPIRQR 874
Query: 537 VSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDDAY 593
+LL GPP +GKT LA IA ES FI + P+ K IG SE QA++ IF A
Sbjct: 875 TGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASE----QAVRDIFIRAQ 930
Query: 594 KSQLSCVVVDDIERL 608
++ + D+ E +
Sbjct: 931 AAKPCILFFDEFESI 945
>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
Length = 753
Score = 147 bits (370), Expect = 5e-35
Identities = 137/464 (29%), Positives = 212/464 (45%), Gaps = 62/464 (13%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
+GGL E +D R + P + +G +G+LL GPPG GKT L R + + A
Sbjct: 202 LGGLS-EAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGA 260
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
E V+ P + GE+E N+R++F A E A+ G ++ DE+DA+C QRGS
Sbjct: 261 -ELLAVSAPALQGSRPGETEENVRRVFQRAREL-----ASRGPSLLFLDEMDALCPQRGS 314
Query: 340 MAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPD 399
A + VV Q+L+ +DG ++V+G TNRPD +D AL RPGR + ++ IG P
Sbjct: 315 RAPES----RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370
Query: 400 EKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
K R +IL + T++M +S+ VD+ LA T + GA+L L R A A+ K
Sbjct: 371 LKQRKEILQVITSKMP----ISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKN 426
Query: 460 STKVEVD----MEKAESLQVTRGDFLASLENDIKPAFGT---NQEDYASYIMNGIIKWGD 512
+D +E +++Q + + L DIKP ED + I+W
Sbjct: 427 QDNPVIDEIDFLEAFKNIQPSSFRSVIGL-MDIKPVDWEEIGGLEDVKLKLKQS-IEW-- 482
Query: 513 PVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD- 571
P+ + + + Q K VLL GPP KT L +A + F+ + D
Sbjct: 483 PLKFPWEFVRMGLTQPK--------GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADL 534
Query: 572 --KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVL 629
+G SE + + +IF A S + + +D+I+ +L ++ + L VL
Sbjct: 535 FSPFVGDSE----KVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVL 590
Query: 630 LKKAPPQG---------------------RKLLIIGTTSRKDVL 652
L + G R ++II T+R DVL
Sbjct: 591 LNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVL 634
Score = 124 bits (310), Expect = 4e-28
Identities = 87/244 (35%), Positives = 126/244 (51%), Gaps = 33/244 (13%)
Query: 240 FPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESE 299
FP E V +MG KG+LLYGPPGC KT L R + + V +G ++ + +VG+SE
Sbjct: 486 FPWEFV-RMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSV-SGADLFSPFVGDSE 543
Query: 300 ANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKID 359
+ ++F A S I+ DEID+I R + V + V++ LL+++D
Sbjct: 544 KVLSQIFRQARA--------STPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELD 595
Query: 360 GV------------------EQLN-NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDE 400
GV E N ++++I TNRPD++D ALLRPGRL+ + I PD
Sbjct: 596 GVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDH 655
Query: 401 KGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
KGRL IL + T M + DV ++ LA ET FSGA+L L A A+ + +
Sbjct: 656 KGRLSILKVCTKTMP----IGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDA 711
Query: 461 TKVE 464
T V+
Sbjct: 712 TTVK 715
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 146 bits (368), Expect = 8e-35
Identities = 96/268 (35%), Positives = 147/268 (54%), Gaps = 19/268 (7%)
Query: 192 SLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCK 251
+L+ + + +E ++ N W IG L+ + + A + V P+ + +G
Sbjct: 453 ALSSVQPSAKREGFVTVPNVTW----ADIGALE-DIREELTMAILAPVRNPDQFKALGLV 507
Query: 252 HVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEE 311
G+LL GPPGCGKTLLA+ + V GPE+LN YVGESE +R++F A+
Sbjct: 508 TPAGVLLAGPPGCGKTLLAKAVANESGLNFISV-KGPELLNMYVGESERAVRQVFQRAK- 565
Query: 312 EQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIG 371
NS +I FDE+DA+C +R TG VVNQLL+++DG+E + ++
Sbjct: 566 -------NSAPCVIFFDEVDALCPRRSDR--ETGASVRVVNQLLTEMDGLEARQQVFIMA 616
Query: 372 MTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAV 431
TNRPD+ID A+LRPGRL+ + +GLP RL IL T + L ADV+++ +A
Sbjct: 617 ATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTIT-KNGTKPPLDADVNLEAIAG 675
Query: 432 ETK--NFSGAELEGLVRAAQSTAMNRHI 457
+ + ++GA+L LVR A A+ + +
Sbjct: 676 DLRCDCYTGADLSALVREASICALRQEM 703
Score = 141 bits (356), Expect = 2e-33
Identities = 143/495 (28%), Positives = 220/495 (44%), Gaps = 91/495 (18%)
Query: 168 KRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEF 227
KR+K ++ V G + +K KAK + I N + +GG D
Sbjct: 123 KRKKEDLQEVDGEIEAVLQK----------KAKARGLEFQISNVKFE----DVGGNDMTL 168
Query: 228 SDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNG 287
++ + R PE+ +G +G+LL+GPPGCGKTLLA I L+ KV
Sbjct: 169 KEVCKMLIHMR--HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVA-A 225
Query: 288 PEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVH 347
PEI++ GESE +R+LF A ++ II DEIDAI +R S +
Sbjct: 226 PEIVSGVSGESEQKLRELFEQA--------VSNAPCIIFIDEIDAITPKRE--VASKDME 275
Query: 348 DTVVNQLLSKIDGVEQLN---NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL 404
+V QLL+ +D + + +LVIG TNRPD +D AL R GR + ++ +G+PDE R
Sbjct: 276 RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRE 335
Query: 405 QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR---HIKAST 461
+IL ++R L D LA T F GA+L L R A A+NR ++
Sbjct: 336 RILQTLCRKLR----LPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQ 391
Query: 462 KVEVDMEKAESLQVTR----GDFLASLENDIKPAFG--TNQEDYASYIMNGI-------- 507
K +ME S V + + +++++ G +Q+ + M G+
Sbjct: 392 KKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFI 451
Query: 508 --------------------IKWGDPVTRVLDDGE----LLVQQTKNSDR-------TPL 536
+ W D + + D E ++ +N D+ TP
Sbjct: 452 VALSSVQPSAKREGFVTVPNVTWAD-IGALEDIREELTMAILAPVRNPDQFKALGLVTP- 509
Query: 537 VSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKM---IGFSETAKCQAMKKIFDDAY 593
VLL GPP GKT LA +A ES FI + P+ + +G SE +A++++F A
Sbjct: 510 AGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESE----RAVRQVFQRAK 565
Query: 594 KSQLSCVVVDDIERL 608
S + D+++ L
Sbjct: 566 NSAPCVIFFDEVDAL 580
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 9/153 (5%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYK 594
P VLL GPP GKT LA IA E + P +K+ +P+ + G S ++ Q ++++F+ A
Sbjct: 191 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESE-QKLRELFEQAVS 249
Query: 595 SQLSCVVVDDIERLLDYVPIGPR--FSNLVLQALLVL--LKKAPPQGRKLLIIGTTSRKD 650
+ + +D+I+ + + + +V Q L + L R +L+IG T+R D
Sbjct: 250 NAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATAR-VLVIGATNRPD 308
Query: 651 VLQ-EMEMLNAFSTTI--HVPNIATGEQLLEAL 680
L + F I +P+ A+ E++L+ L
Sbjct: 309 SLDPALRRAGRFDREICLGIPDEASRERILQTL 341
>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
Length = 856
Score = 146 bits (368), Expect = 8e-35
Identities = 96/268 (35%), Positives = 147/268 (54%), Gaps = 19/268 (7%)
Query: 192 SLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCK 251
+L+ + + +E ++ N W IG L+ + + A + V P+ + +G
Sbjct: 559 ALSSVQPSAKREGFVTVPNVTW----ADIGALE-DIREELTMAILAPVRNPDQFKALGLV 613
Query: 252 HVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEE 311
G+LL GPPGCGKTLLA+ + V GPE+LN YVGESE +R++F A+
Sbjct: 614 TPAGVLLAGPPGCGKTLLAKAVANESGLNFISV-KGPELLNMYVGESERAVRQVFQRAK- 671
Query: 312 EQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIG 371
NS +I FDE+DA+C +R TG VVNQLL+++DG+E + ++
Sbjct: 672 -------NSAPCVIFFDEVDALCPRRSDR--ETGASVRVVNQLLTEMDGLEARQQVFIMA 722
Query: 372 MTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAV 431
TNRPD+ID A+LRPGRL+ + +GLP RL IL T + L ADV+++ +A
Sbjct: 723 ATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTIT-KNGTKPPLDADVNLEAIAG 781
Query: 432 ETK--NFSGAELEGLVRAAQSTAMNRHI 457
+ + ++GA+L LVR A A+ + +
Sbjct: 782 DLRCDCYTGADLSALVREASICALRQEM 809
Score = 141 bits (356), Expect = 2e-33
Identities = 143/495 (28%), Positives = 220/495 (44%), Gaps = 91/495 (18%)
Query: 168 KRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEF 227
KR+K ++ V G + +K KAK + I N + +GG D
Sbjct: 229 KRKKEDLQEVDGEIEAVLQK----------KAKARGLEFQISNVKFE----DVGGNDMTL 274
Query: 228 SDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNG 287
++ + R PE+ +G +G+LL+GPPGCGKTLLA I L+ KV
Sbjct: 275 KEVCKMLIHMR--HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVA-A 331
Query: 288 PEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVH 347
PEI++ GESE +R+LF A ++ II DEIDAI +R S +
Sbjct: 332 PEIVSGVSGESEQKLRELFEQA--------VSNAPCIIFIDEIDAITPKRE--VASKDME 381
Query: 348 DTVVNQLLSKIDGVEQLN---NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL 404
+V QLL+ +D + + +LVIG TNRPD +D AL R GR + ++ +G+PDE R
Sbjct: 382 RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRE 441
Query: 405 QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR---HIKAST 461
+IL ++R L D LA T F GA+L L R A A+NR ++
Sbjct: 442 RILQTLCRKLR----LPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQ 497
Query: 462 KVEVDMEKAESLQVTR----GDFLASLENDIKPAFG--TNQEDYASYIMNGI-------- 507
K +ME S V + + +++++ G +Q+ + M G+
Sbjct: 498 KKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFI 557
Query: 508 --------------------IKWGDPVTRVLDDGE----LLVQQTKNSDR-------TPL 536
+ W D + + D E ++ +N D+ TP
Sbjct: 558 VALSSVQPSAKREGFVTVPNVTWAD-IGALEDIREELTMAILAPVRNPDQFKALGLVTP- 615
Query: 537 VSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKM---IGFSETAKCQAMKKIFDDAY 593
VLL GPP GKT LA +A ES FI + P+ + +G SE +A++++F A
Sbjct: 616 AGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESE----RAVRQVFQRAK 671
Query: 594 KSQLSCVVVDDIERL 608
S + D+++ L
Sbjct: 672 NSAPCVIFFDEVDAL 686
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 9/153 (5%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYK 594
P VLL GPP GKT LA IA E + P +K+ +P+ + G S ++ Q ++++F+ A
Sbjct: 297 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESE-QKLRELFEQAVS 355
Query: 595 SQLSCVVVDDIERLLDYVPIGPR--FSNLVLQALLVL--LKKAPPQGRKLLIIGTTSRKD 650
+ + +D+I+ + + + +V Q L + L R +L+IG T+R D
Sbjct: 356 NAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATAR-VLVIGATNRPD 414
Query: 651 VLQ-EMEMLNAFSTTI--HVPNIATGEQLLEAL 680
L + F I +P+ A+ E++L+ L
Sbjct: 415 SLDPALRRAGRFDREICLGIPDEASRERILQTL 447
>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
Length = 440
Score = 145 bits (366), Expect = 1e-34
Identities = 95/269 (35%), Positives = 148/269 (55%), Gaps = 32/269 (11%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
IGGLD + +I + + + PE E+MG K KG++LYGPPG GKTLLA+ + +A
Sbjct: 187 IGGLDNQIQEI-KESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSA 245
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR-- 337
+VV G E++ KY+G+ +R+LF AEE I+ DEIDAI +R
Sbjct: 246 TFLRVV-GSELIQKYLGDGPKLVRELFRVAEEHAPS--------IVFIDEIDAIGTKRYD 296
Query: 338 GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
+ G + T++ +LL+++DG + ++ VI TNR + +D AL+RPGR++ K+E L
Sbjct: 297 SNSGGEREIQRTML-ELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPL 355
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
PDEK + +I IHT+RM L+ DV + +L + + SGA+++ + A A+
Sbjct: 356 PDEKTKKRIFQIHTSRM----TLADDVTLDDLIMAKDDLSGADIKAICTEAGLMAL---- 407
Query: 458 KASTKVEVDMEKAESLQVTRGDFLASLEN 486
+ ++VT DF S EN
Sbjct: 408 -----------RERRMKVTNEDFKKSKEN 425
Score = 35.0 bits (79), Expect = 0.25
Identities = 21/77 (27%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDD 591
P V+L GPP +GKT LA +A +++ F+++ + K +G + ++++F
Sbjct: 218 PPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGP----KLVRELFRV 273
Query: 592 AYKSQLSCVVVDDIERL 608
A + S V +D+I+ +
Sbjct: 274 AEEHAPSIVFIDEIDAI 290
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 139 bits (349), Expect = 1e-32
Identities = 93/262 (35%), Positives = 140/262 (53%), Gaps = 23/262 (8%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
IGGL ++ ++ R + PE+ +++G KG LLYGPPG GKTLLAR + L+
Sbjct: 149 IGGLSEQIREL-REVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDC 207
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
KVV+ I++KY+GES IR++F A + Q II DEIDAI +R S
Sbjct: 208 NFLKVVSS-SIVDKYIGESARLIREMFNYARDHQPC--------IIFMDEIDAIGGRRFS 258
Query: 340 MAGSTGVH-DTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLP 398
S + +LL+++DG + L+ + +I TNRPD +D ALLRPGRL+ K+ I LP
Sbjct: 259 EGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLP 318
Query: 399 DEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGL--------VRAAQS 450
+E+ RL IL IH + H ++D + + + F+GA+L + +RA
Sbjct: 319 NEQARLDILKIHAGPITKH----GEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD 374
Query: 451 TAMNRHIKASTKVEVDMEKAES 472
+ + + D +K ES
Sbjct: 375 FVVQEDFMKAVRKVADSKKLES 396
Score = 39.3 bits (90), Expect = 0.013
Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKP-AFGTNQEDYASYIMNGIIKWGDPVT 515
+K T+V +DM T + L ++ P + + ED + + I + +
Sbjct: 106 LKPGTRVALDM--------TTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIR 157
Query: 516 RVLDDGELLVQQTKNSDRTPLV---SVLLEGPPHSGKTALAAKIAEESNFPFIKICSP-- 570
+ + EL + + R ++ LL GPP +GKT LA +A + + F+K+ S
Sbjct: 158 ELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSI 217
Query: 571 -DKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERL 608
DK IG S + ++++F+ A Q + +D+I+ +
Sbjct: 218 VDKYIGES----ARLIREMFNYARDHQPCIIFMDEIDAI 252
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 134 bits (338), Expect = 2e-31
Identities = 93/264 (35%), Positives = 144/264 (54%), Gaps = 24/264 (9%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
IGGLDK+ ++ A + E E +G + KG+L+YGPPG GKTLLAR A
Sbjct: 188 IGGLDKQIQELVE-AIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKA 246
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR-- 337
K+ GP+++ ++G+ +R FA A+E+ II DE+DAI +R
Sbjct: 247 TFLKLA-GPQLVQMFIGDGAKLVRDAFALAKEKAPS--------IIFIDELDAIGTKRFD 297
Query: 338 GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
AG V T++ +LL+++DG + + VI TNR D++D ALLR GRL+ K+E +
Sbjct: 298 SEKAGDREVQRTML-ELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPM 356
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
P+E+ R +I+ IH+ +M +S DV+ +ELA T +F+GA+ + + A A+ R
Sbjct: 357 PNEEARARIMQIHSRKMN----VSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGA 412
Query: 458 KASTK-------VEVDMEKAESLQ 474
T +EV +K +LQ
Sbjct: 413 TELTHEDYMEGILEVQAKKKANLQ 436
Score = 38.9 bits (89), Expect = 0.018
Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%)
Query: 526 QQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAM 585
++ +N P VL+ GPP +GKT LA A ++ F+K+ P + F + +
Sbjct: 210 EKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG-AKLV 268
Query: 586 KKIFDDAYKSQLSCVVVDDIERL----LDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLL 641
+ F A + S + +D+++ + D G R + LL L P ++
Sbjct: 269 RDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQP-NTQVK 327
Query: 642 IIGTTSRKDVL 652
+I T+R D+L
Sbjct: 328 VIAATNRVDIL 338
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 134 bits (338), Expect = 2e-31
Identities = 98/264 (37%), Positives = 142/264 (53%), Gaps = 28/264 (10%)
Query: 239 VFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVV----NGPEIL 291
VFP PEI E+ + +G L YGPPG GKTL+AR + + + KV G + L
Sbjct: 417 VFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCL 476
Query: 292 NKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVV 351
+K+VGESE +R LF +Q L S II FDEID + R S +H ++V
Sbjct: 477 SKWVGESERQLRLLF-----DQAYLMRPS---IIFFDEIDGLAPVRSSRQDQ--IHSSIV 526
Query: 352 NQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHT 411
+ LL+ +DG++ I+VIG TNR D ID AL RPGR + + LPD+K R IL IHT
Sbjct: 527 STLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHT 586
Query: 412 ARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH----IKASTKVEVDM 467
R +D + ELA + + GA+++ L A A+ R +S K+++D+
Sbjct: 587 ---RDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDV 643
Query: 468 EKAESLQVTRGDFLASLENDIKPA 491
S+ ++ DF +++N I PA
Sbjct: 644 ---SSIVLSAQDFYHAMQN-IVPA 663
Score = 37.4 bits (85), Expect = 0.051
Identities = 33/123 (26%), Positives = 59/123 (47%), Gaps = 20/123 (16%)
Query: 540 LLEGPPHSGKTALAAKIAEESNFPFIKIC--------SPDKMIGFSETAKCQAMKKIFDD 591
L GPP +GKT +A +A E + K+ K +G SE + ++ +FD
Sbjct: 438 LFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESE----RQLRLLFDQ 493
Query: 592 AYKSQLSCVVVDDIERLLDYVPI----GPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTS 647
AY + S + D+I+ L P+ + + ++ LL L+ +G ++++IG T+
Sbjct: 494 AYLMRPSIIFFDEIDGL---APVRSSRQDQIHSSIVSTLLALMDGLDNRG-EIVVIGATN 549
Query: 648 RKD 650
R D
Sbjct: 550 RLD 552
>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
[Homo sapiens]
Length = 414
Score = 134 bits (336), Expect = 4e-31
Identities = 100/328 (30%), Positives = 164/328 (50%), Gaps = 27/328 (8%)
Query: 152 IEAMDPSILKGEPATGKRQKIEV------GLVVGNSQVAFEKAENSSLNLIGKAKTKENR 205
+EA+D + TG + + L+ N+ VA K N+ ++++
Sbjct: 89 LEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIM 148
Query: 206 QSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCG 265
+ + IGG+D + ++ R A + E+ +Q+G +G+L+YGPPGCG
Sbjct: 149 MLTSDQKPDVMYADIGGMDIQKQEV-REAVELPLTHFELYKQIGIDPPRGVLMYGPPGCG 207
Query: 266 KTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHII 325
KT+LA+ + A +VV G E + KY+GE +R +F RL + II
Sbjct: 208 KTMLAKAVAHHTTAAFIRVV-GSEFVQKYLGEGPRMVRDVF--------RLAKENAPAII 258
Query: 326 IFDEIDAICKQR-GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALL 384
DEIDAI +R + G+ ++ +LL+++DG +Q N+ VI TNR D +D ALL
Sbjct: 259 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALL 318
Query: 385 RPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGL 444
RPGRL+ K+E LPD + + I T++M LS +VD+++ SGA++ +
Sbjct: 319 RPGRLDRKIEFPLPDRRQKRLIFSTITSKMN----LSEEVDLEDYVARPDKISGADINSI 374
Query: 445 VRAAQSTAM--NRHIKASTKVEVDMEKA 470
+ + A+ NR+I + D EKA
Sbjct: 375 CQESGMLAVRENRYIVLAK----DFEKA 398
Score = 32.0 bits (71), Expect = 2.1
Identities = 20/77 (25%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDD 591
P VL+ GPP GKT LA +A + FI++ + K +G + ++ +F
Sbjct: 194 PPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGP----RMVRDVFRL 249
Query: 592 AYKSQLSCVVVDDIERL 608
A ++ + + +D+I+ +
Sbjct: 250 AKENAPAIIFIDEIDAI 266
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 5/71 (7%)
Query: 289 EILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHD 348
E+ +Y+ + + N++K F A+EE +R+ + ++I ++A+ + + +TG +
Sbjct: 51 EVQEEYIKDEQKNLKKEFLHAQEEVKRI---QSIPLVIGQFLEAVDQNTAIVGSTTGSNY 107
Query: 349 TVVNQLLSKID 359
V ++LS ID
Sbjct: 108 YV--RILSTID 116
>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
sapiens]
Length = 387
Score = 134 bits (336), Expect = 4e-31
Identities = 100/328 (30%), Positives = 164/328 (50%), Gaps = 27/328 (8%)
Query: 152 IEAMDPSILKGEPATGKRQKIEV------GLVVGNSQVAFEKAENSSLNLIGKAKTKENR 205
+EA+D + TG + + L+ N+ VA K N+ ++++
Sbjct: 62 LEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIM 121
Query: 206 QSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCG 265
+ + IGG+D + ++ R A + E+ +Q+G +G+L+YGPPGCG
Sbjct: 122 MLTSDQKPDVMYADIGGMDIQKQEV-REAVELPLTHFELYKQIGIDPPRGVLMYGPPGCG 180
Query: 266 KTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHII 325
KT+LA+ + A +VV G E + KY+GE +R +F RL + II
Sbjct: 181 KTMLAKAVAHHTTAAFIRVV-GSEFVQKYLGEGPRMVRDVF--------RLAKENAPAII 231
Query: 326 IFDEIDAICKQR-GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALL 384
DEIDAI +R + G+ ++ +LL+++DG +Q N+ VI TNR D +D ALL
Sbjct: 232 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALL 291
Query: 385 RPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGL 444
RPGRL+ K+E LPD + + I T++M LS +VD+++ SGA++ +
Sbjct: 292 RPGRLDRKIEFPLPDRRQKRLIFSTITSKMN----LSEEVDLEDYVARPDKISGADINSI 347
Query: 445 VRAAQSTAM--NRHIKASTKVEVDMEKA 470
+ + A+ NR+I + D EKA
Sbjct: 348 CQESGMLAVRENRYIVLAK----DFEKA 371
Score = 32.0 bits (71), Expect = 2.1
Identities = 20/77 (25%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDD 591
P VL+ GPP GKT LA +A + FI++ + K +G + ++ +F
Sbjct: 167 PPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGP----RMVRDVFRL 222
Query: 592 AYKSQLSCVVVDDIERL 608
A ++ + + +D+I+ +
Sbjct: 223 AKENAPAIIFIDEIDAI 239
>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
Length = 418
Score = 134 bits (336), Expect = 4e-31
Identities = 100/328 (30%), Positives = 164/328 (50%), Gaps = 27/328 (8%)
Query: 152 IEAMDPSILKGEPATGKRQKIEV------GLVVGNSQVAFEKAENSSLNLIGKAKTKENR 205
+EA+D + TG + + L+ N+ VA K N+ ++++
Sbjct: 93 LEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIM 152
Query: 206 QSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCG 265
+ + IGG+D + ++ R A + E+ +Q+G +G+L+YGPPGCG
Sbjct: 153 MLTSDQKPDVMYADIGGMDIQKQEV-REAVELPLTHFELYKQIGIDPPRGVLMYGPPGCG 211
Query: 266 KTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHII 325
KT+LA+ + A +VV G E + KY+GE +R +F RL + II
Sbjct: 212 KTMLAKAVAHHTTAAFIRVV-GSEFVQKYLGEGPRMVRDVF--------RLAKENAPAII 262
Query: 326 IFDEIDAICKQR-GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALL 384
DEIDAI +R + G+ ++ +LL+++DG +Q N+ VI TNR D +D ALL
Sbjct: 263 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALL 322
Query: 385 RPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGL 444
RPGRL+ K+E LPD + + I T++M LS +VD+++ SGA++ +
Sbjct: 323 RPGRLDRKIEFPLPDRRQKRLIFSTITSKMN----LSEEVDLEDYVARPDKISGADINSI 378
Query: 445 VRAAQSTAM--NRHIKASTKVEVDMEKA 470
+ + A+ NR+I + D EKA
Sbjct: 379 CQESGMLAVRENRYIVLAK----DFEKA 402
Score = 32.0 bits (71), Expect = 2.1
Identities = 20/77 (25%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDD 591
P VL+ GPP GKT LA +A + FI++ + K +G + ++ +F
Sbjct: 198 PPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGP----RMVRDVFRL 253
Query: 592 AYKSQLSCVVVDDIERL 608
A ++ + + +D+I+ +
Sbjct: 254 AKENAPAIIFIDEIDAI 270
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 5/71 (7%)
Query: 289 EILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHD 348
E+ +Y+ + + N++K F A+EE +R+ + ++I ++A+ + + +TG +
Sbjct: 55 EVQEEYIKDEQKNLKKEFLHAQEEVKRI---QSIPLVIGQFLEAVDQNTAIVGSTTGSNY 111
Query: 349 TVVNQLLSKID 359
V ++LS ID
Sbjct: 112 YV--RILSTID 120
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 132 bits (333), Expect = 9e-31
Identities = 92/280 (32%), Positives = 143/280 (51%), Gaps = 31/280 (11%)
Query: 220 IGGLDKEFSDIFRRAFASRVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKM 276
+GGL + + VFP PE+ E+ + +G L YGPPG GKTL+AR +
Sbjct: 428 VGGLSNHIAALKEMV----VFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANE 483
Query: 277 LNAREPKVV----NGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDA 332
+ + +V G + L+K+VGESE +R LF A + + II FDEID
Sbjct: 484 CSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPS--------IIFFDEIDG 535
Query: 333 ICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVK 392
+ R S +H ++V+ LL+ +DG++ I+VIG TNR D ID AL RPGR + +
Sbjct: 536 LAPVRSSRQDQ--IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDRE 593
Query: 393 MEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTA 452
LPD++ R +IL IHT L D ++ELA + GA+++ + A A
Sbjct: 594 FLFSLPDKEARKEILKIHTRDWNPKPL---DTFLEELAENCVGYCGADIKSICAEAALCA 650
Query: 453 MNRH----IKASTKVEVDMEKAESLQVTRGDFLASLENDI 488
+ R S K+++D+ S+ ++ DF +++ I
Sbjct: 651 LRRRYPQIYTTSEKLQLDL---SSINISAKDFEVAMQKMI 687
Score = 38.5 bits (88), Expect = 0.023
Identities = 35/127 (27%), Positives = 61/127 (48%), Gaps = 28/127 (22%)
Query: 540 LLEGPPHSGKTALAAKIAEESNFPFIKICSP-DKMIGF--SETAKC---------QAMKK 587
L GPP +GKT +A +A E CS DK + F + A C + ++
Sbjct: 464 LFYGPPGTGKTLVARALANE--------CSQGDKRVAFFMRKGADCLSKWVGESERQLRL 515
Query: 588 IFDDAYKSQLSCVVVDDIERLLDYVPI----GPRFSNLVLQALLVLLKKAPPQGRKLLII 643
+FD AY+ + S + D+I+ L P+ + + ++ LL L+ +G ++++I
Sbjct: 516 LFDQAYQMRPSIIFFDEIDGL---APVRSSRQDQIHSSIVSTLLALMDGLDSRG-EIVVI 571
Query: 644 GTTSRKD 650
G T+R D
Sbjct: 572 GATNRLD 578
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 130 bits (328), Expect = 3e-30
Identities = 85/229 (37%), Positives = 126/229 (55%), Gaps = 17/229 (7%)
Query: 255 GILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR 314
G+LL+GPPG GKTLLA+ + + V GPE++N YVG+SE N+R++FA A
Sbjct: 739 GLLLHGPPGTGKTLLAKAVATECSLTFLSV-KGPELINMYVGQSEENVREVFARARA--- 794
Query: 315 RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTN 374
+ II FDE+D++ RG S GV D VV+QLL+++DG+ ++ VIG TN
Sbjct: 795 -----AAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATN 849
Query: 375 RPDLIDEALLRPGRLEVKMEIGL-PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVET 433
RPDL+D ALLRPGR + + +G D +L++L T + + +S + L
Sbjct: 850 RPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSL---VNVLDCCP 906
Query: 434 KNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAES-LQVTRGDFL 481
+GA+L L A + A+ R + +E +E S L +T D L
Sbjct: 907 PQLTGADLYSLCSDAMTAALKRRVH---DLEEGLEPGSSALMLTMEDLL 952
Score = 56.2 bits (134), Expect = 1e-07
Identities = 98/419 (23%), Positives = 165/419 (39%), Gaps = 52/419 (12%)
Query: 256 ILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRR 315
+LL GPPGCGKT + L KV + + G E ++ +F+ A +
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCS-SLCAESSGAVETKLQAIFSRARRCRPA 524
Query: 316 LGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNR 375
+++ +D + + R + V V+ LL D + ++V+ T+R
Sbjct: 525 --------VLLLTAVDLLGRDRDGLGEDARVM-AVLRHLLLNEDPLNSCPPLMVVATTSR 575
Query: 376 PDLI--DEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVET 433
+ D P LEV E RL IL TA H L +V++ +LA
Sbjct: 576 AQDLPADVQTAFPHELEVPAL----SEGQRLSILRALTA----HLPLGQEVNLAQLARRC 627
Query: 434 KNFSGAELEGLV----RAAQSTAMNRHIKASTKVEVDMEKAES----LQVTRGDFLASLE 485
F +L L+ RAA + N + E + E + L G L L+
Sbjct: 628 AGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQ 687
Query: 486 NDIKPAFGTNQEDYASYIMNGIIKWG-----DPVTRVLDDGELLVQQTKNSDRTPLVSVL 540
A G + S+ G ++ + + L+ ELL + S +L
Sbjct: 688 TAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS------GLL 741
Query: 541 LEGPPHSGKTALAAKIAEESNFPFIKICSPDKM---IGFSETAKCQAMKKIFDDAYKSQL 597
L GPP +GKT LA +A E + F+ + P+ + +G SE + ++++F A +
Sbjct: 742 LHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSE----ENVREVFARARAAAP 797
Query: 598 SCVVVDDIERLLD----YVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVL 652
+ D+++ L G +V Q L L + + +IG T+R D+L
Sbjct: 798 CIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAEL--DGLHSTQDVFVIGATNRPDLL 854
Score = 38.9 bits (89), Expect = 0.018
Identities = 42/165 (25%), Positives = 73/165 (44%), Gaps = 13/165 (7%)
Query: 538 SVLLEGPPHSGKTALAAKIAEESNFPFIKI-CSPDKMIGFSETAKCQAMKKIFDDAYKSQ 596
SVLL GPP GKT + A +K+ CS + S A ++ IF A + +
Sbjct: 465 SVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCS--SLCAESSGAVETKLQAIFSRARRCR 522
Query: 597 LSCVVVDDIERL-LDYVPIGPRFSNLVLQALLVL----LKKAPPQGRKLLIIGTTSRKDV 651
+ +++ ++ L D +G + + L+L L PP L+++ TTSR
Sbjct: 523 PAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPP----LMVVATTSRAQD 578
Query: 652 LQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQ 696
L ++ AF + VP ++ G++L L + + +AQ
Sbjct: 579 L-PADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQ 622
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 130 bits (326), Expect = 6e-30
Identities = 89/245 (36%), Positives = 130/245 (53%), Gaps = 17/245 (6%)
Query: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
+GG KE + R + + PE +G + KG+LL+GPPG GKTL AR + +A
Sbjct: 177 VGGC-KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDA 235
Query: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR-- 337
+V+ G E++ KYVGE +R+LF A ++ L I FDEIDAI R
Sbjct: 236 CFIRVI-GSELVQKYVGEGARMVRELFEMARTKKACL--------IFFDEIDAIGGARFD 286
Query: 338 GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
G V T++ +L++++DG + NI V+ TNRPD +D AL+RPGRL+ K+E L
Sbjct: 287 DGAGGDNEVQRTML-ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSL 345
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
PD +GR I IH M + D+ + LA N +GAE+ + A A+
Sbjct: 346 PDLEGRTHIFKIHARSMS----VERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARR 401
Query: 458 KASTK 462
K +T+
Sbjct: 402 KIATE 406
Score = 33.9 bits (76), Expect = 0.56
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 22/130 (16%)
Query: 535 PLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDD 591
P VLL GPP +GKT A +A ++ FI++ + K +G + ++++F+
Sbjct: 208 PPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVG----EGARMVRELFEM 263
Query: 592 AYKSQLSCVVVDDIERLLDYVPIGPRF------SNLVLQALLVLLKKA---PPQGRKLLI 642
A + + D+I+ + G RF N V + +L L+ + P+G + +
Sbjct: 264 ARTKKACLIFFDEIDAI-----GGARFDDGAGGDNEVQRTMLELINQLDGFDPRG-NIKV 317
Query: 643 IGTTSRKDVL 652
+ T+R D L
Sbjct: 318 LMATNRPDTL 327
>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
Length = 797
Score = 129 bits (323), Expect = 1e-29
Identities = 82/221 (37%), Positives = 118/221 (53%), Gaps = 13/221 (5%)
Query: 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV-VNGPEILNKYVGESEA 300
P+ + +G K KG +L GPPG GKTLLA+ N P + V+G E L +VG A
Sbjct: 330 PKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV--PFITVSGSEFLEMFVGVGPA 387
Query: 301 NIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRG-SMAGSTGVHDTVVNQLLSKID 359
+R LFA L + I+ DEIDA+ ++RG G + +NQLL ++D
Sbjct: 388 RVRDLFA--------LARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMD 439
Query: 360 GVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQL 419
G N++++ TNRPD++D ALLRPGR + ++ IG PD KGR I +H ++
Sbjct: 440 GFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDST 499
Query: 420 LSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
L D ++LA T FSGA++ + A A RH+ S
Sbjct: 500 LEKDKLARKLASLTPGFSGADVANVCNEAALIAA-RHLSDS 539
Score = 36.2 bits (82), Expect = 0.11
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 540 LLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSC 599
+L GPP +GKT LA A E+N PFI + + + F + ++ +F A K+
Sbjct: 345 ILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPAR-VRDLFALARKNAPCI 403
Query: 600 VVVDDIE 606
+ +D+I+
Sbjct: 404 LFIDEID 410
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 114 bits (285), Expect = 3e-25
Identities = 88/254 (34%), Positives = 130/254 (51%), Gaps = 21/254 (8%)
Query: 217 KMGIGGLDKEFSDIFR-----RAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLAR 271
KMG G K+ + + R F + PE Q+G K KG LL GPPGCGKTLLA+
Sbjct: 301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK 360
Query: 272 QIGKMLNAREPKV-VNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEI 330
+ A+ P + + GPE + G A +R LF +A I+ DEI
Sbjct: 361 AVAT--EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPC--------IVYIDEI 410
Query: 331 DAICKQRGS-MAG-STGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGR 388
DA+ K+R + M+G S + +NQLL ++DG+ ++++V+ TNR D++D AL+RPGR
Sbjct: 411 DAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGR 470
Query: 389 LEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLV-RA 447
L+ + I LP + R +I H ++ Q S+ + LA T FSGA++ + A
Sbjct: 471 LDRHVFIDLPTLQERREIFEQHLKSLKLTQ--SSTFYSQRLAELTPGFSGADIANICNEA 528
Query: 448 AQSTAMNRHIKAST 461
A A H T
Sbjct: 529 ALHAAREGHTSVHT 542
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/126 (29%), Positives = 66/126 (52%), Gaps = 23/126 (18%)
Query: 540 LLEGPPHSGKTALAAKIAEESNFPFIKICSPD--KMIGFSETAKCQAMKKIFDDAYKSQL 597
LL GPP GKT LA +A E+ PF+ + P+ ++IG A+ ++ +F +A +++
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAAR---VRSLFKEA-RARA 401
Query: 598 SCVV-VDDIERLLDYVPIGPR-------FSNL-VLQALLVLLKKAPPQGR--KLLIIGTT 646
C+V +D+I+ +G + FSN Q L LL + G ++++ +T
Sbjct: 402 PCIVYIDEID------AVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLAST 455
Query: 647 SRKDVL 652
+R D+L
Sbjct: 456 NRADIL 461
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 113 bits (283), Expect = 6e-25
Identities = 86/260 (33%), Positives = 134/260 (51%), Gaps = 25/260 (9%)
Query: 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQ 313
KG+L+ GPPG GKT+LA+ + V+ + +KY GESE +R LF E
Sbjct: 242 KGVLMVGPPGTGKTMLAKAVATECGTTFFN-VSSSTLTSKYRGESEKLVRLLF-----EM 295
Query: 314 RRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGV-------EQLNN 366
R A + I DEID+IC +RG+ + V ++LL ++DGV +
Sbjct: 296 ARFYAPT---TIFIDEIDSICSRRGT-SDEHEASRRVKSELLIQMDGVGGALENDDPSKM 351
Query: 367 ILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDI 426
++V+ TN P IDEAL R RLE ++ I LP KGR ++L I+ + L D+ +
Sbjct: 352 VMVLAATNFPWDIDEALRR--RLEKRIYIPLPTAKGRAELLKINLREVE----LDPDIQL 405
Query: 427 KELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQ--VTRGDFLASL 484
+++A + + +SGA++ + R A AM R I + E+ E LQ VT+GDF +L
Sbjct: 406 EDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELAL 465
Query: 485 ENDIKPAFGTNQEDYASYIM 504
+ K + E Y +++
Sbjct: 466 KKIAKSVSAADLEKYEKWMV 485
Score = 34.7 bits (78), Expect = 0.33
Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 533 RTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICS---PDKMIGFSETAKCQAMKKIF 589
R P VL+ GPP +GKT LA +A E F + S K G SE + ++ +F
Sbjct: 238 RRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESE----KLVRLLF 293
Query: 590 DDAYKSQLSCVVVDDIERL 608
+ A + + +D+I+ +
Sbjct: 294 EMARFYAPTTIFIDEIDSI 312
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 113 bits (283), Expect = 6e-25
Identities = 86/260 (33%), Positives = 134/260 (51%), Gaps = 25/260 (9%)
Query: 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQ 313
KG+L+ GPPG GKT+LA+ + V+ + +KY GESE +R LF E
Sbjct: 242 KGVLMVGPPGTGKTMLAKAVATECGTTFFN-VSSSTLTSKYRGESEKLVRLLF-----EM 295
Query: 314 RRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGV-------EQLNN 366
R A + I DEID+IC +RG+ + V ++LL ++DGV +
Sbjct: 296 ARFYAPT---TIFIDEIDSICSRRGT-SDEHEASRRVKSELLIQMDGVGGALENDDPSKM 351
Query: 367 ILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDI 426
++V+ TN P IDEAL R RLE ++ I LP KGR ++L I+ + L D+ +
Sbjct: 352 VMVLAATNFPWDIDEALRR--RLEKRIYIPLPTAKGRAELLKINLREVE----LDPDIQL 405
Query: 427 KELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQ--VTRGDFLASL 484
+++A + + +SGA++ + R A AM R I + E+ E LQ VT+GDF +L
Sbjct: 406 EDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELAL 465
Query: 485 ENDIKPAFGTNQEDYASYIM 504
+ K + E Y +++
Sbjct: 466 KKIAKSVSAADLEKYEKWMV 485
Score = 34.7 bits (78), Expect = 0.33
Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 533 RTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICS---PDKMIGFSETAKCQAMKKIF 589
R P VL+ GPP +GKT LA +A E F + S K G SE + ++ +F
Sbjct: 238 RRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESE----KLVRLLF 293
Query: 590 DDAYKSQLSCVVVDDIERL 608
+ A + + +D+I+ +
Sbjct: 294 EMARFYAPTTIFIDEIDSI 312
>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
Length = 773
Score = 113 bits (283), Expect = 6e-25
Identities = 84/236 (35%), Positives = 125/236 (52%), Gaps = 22/236 (9%)
Query: 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGE 297
P+ +G K KGILL GPPG GKTLLAR + A E V +G E +VG
Sbjct: 361 PQKFTILGGKLPKGILLVGPPGTGKTLLARAV-----AGEADVPFYYASGSEFDEMFVGV 415
Query: 298 SEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK 357
+ IR LF +A+ AN+ +I DE+D++ +R T+ NQLL++
Sbjct: 416 GASRIRNLFREAK-------ANAPC-VIFIDELDSVGGKRIESPMHPYSRQTI-NQLLAE 466
Query: 358 IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH 417
+DG + +++IG TN P+ +D AL+RPGR ++++ + PD KGR +IL + +++
Sbjct: 467 MDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFD 526
Query: 418 QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESL 473
Q VD + +A T FSGAELE LV A A + T E++ K + L
Sbjct: 527 Q----SVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKIL 578
Score = 35.4 bits (80), Expect = 0.19
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 8/118 (6%)
Query: 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLS 598
+LL GPP +GKT LA +A E++ PF S + ++ +F +A K+
Sbjct: 375 ILLVGPPGTGKTLLARAVAGEADVPFY-YASGSEFDEMFVGVGASRIRNLFREA-KANAP 432
Query: 599 CVV----VDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVL 652
CV+ +D + P+ P + Q L + P +G ++IIG T+ + L
Sbjct: 433 CVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEG--VIIIGATNFPEAL 488
>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
Length = 716
Score = 113 bits (283), Expect = 6e-25
Identities = 84/236 (35%), Positives = 125/236 (52%), Gaps = 22/236 (9%)
Query: 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGE 297
P+ +G K KGILL GPPG GKTLLAR + A E V +G E +VG
Sbjct: 304 PQKFTILGGKLPKGILLVGPPGTGKTLLARAV-----AGEADVPFYYASGSEFDEMFVGV 358
Query: 298 SEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK 357
+ IR LF +A+ AN+ +I DE+D++ +R T+ NQLL++
Sbjct: 359 GASRIRNLFREAK-------ANAPC-VIFIDELDSVGGKRIESPMHPYSRQTI-NQLLAE 409
Query: 358 IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH 417
+DG + +++IG TN P+ +D AL+RPGR ++++ + PD KGR +IL + +++
Sbjct: 410 MDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFD 469
Query: 418 QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESL 473
Q VD + +A T FSGAELE LV A A + T E++ K + L
Sbjct: 470 Q----SVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKIL 521
Score = 35.4 bits (80), Expect = 0.19
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 8/118 (6%)
Query: 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLS 598
+LL GPP +GKT LA +A E++ PF S + ++ +F +A K+
Sbjct: 318 ILLVGPPGTGKTLLARAVAGEADVPFY-YASGSEFDEMFVGVGASRIRNLFREA-KANAP 375
Query: 599 CVV----VDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVL 652
CV+ +D + P+ P + Q L + P +G ++IIG T+ + L
Sbjct: 376 CVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEG--VIIIGATNFPEAL 431
>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
Length = 415
Score = 112 bits (279), Expect = 2e-24
Identities = 76/244 (31%), Positives = 125/244 (51%), Gaps = 31/244 (12%)
Query: 221 GGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAR 280
GGLD + +I + + + PE E+MG K KG++L GPPG L
Sbjct: 175 GGLDNQIQEI-KESMELPLPHPEYYEEMGTKPPKGVILCGPPGTATFLR----------- 222
Query: 281 EPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR--G 338
V G E++ KY+G+ +R++F AEE I+ DEI+AI +R
Sbjct: 223 ----VVGSELIQKYLGDGPKLVRQVFQVAEEHAPS--------IMFTDEIEAIGTKRYDS 270
Query: 339 SMAGSTGVHDTVVN-QLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
+ G + T++ +LL+++ G + ++ VI T + + +D L+RPGR++ K+E L
Sbjct: 271 NSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHL 330
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
PDEK + I IHT+RM L+ DV + +L + +FSGA+++ + A A+ H
Sbjct: 331 PDEKTKKHIFQIHTSRM----TLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHR 386
Query: 458 KAST 461
+T
Sbjct: 387 MKAT 390
>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
Length = 415
Score = 112 bits (279), Expect = 2e-24
Identities = 76/244 (31%), Positives = 125/244 (51%), Gaps = 31/244 (12%)
Query: 221 GGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAR 280
GGLD + +I + + + PE E+MG K KG++L GPPG L
Sbjct: 175 GGLDNQIQEI-KESMELPLPHPEYYEEMGTKPPKGVILCGPPGTATFLR----------- 222
Query: 281 EPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR--G 338
V G E++ KY+G+ +R++F AEE I+ DEI+AI +R
Sbjct: 223 ----VVGSELIQKYLGDGPKLVRQVFQVAEEHAPS--------IMFTDEIEAIGTKRYDS 270
Query: 339 SMAGSTGVHDTVVN-QLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
+ G + T++ +LL+++ G + ++ VI T + + +D L+RPGR++ K+E L
Sbjct: 271 NSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHL 330
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
PDEK + I IHT+RM L+ DV + +L + +FSGA+++ + A A+ H
Sbjct: 331 PDEKTKKHIFQIHTSRM----TLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHR 386
Query: 458 KAST 461
+T
Sbjct: 387 MKAT 390
>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
sapiens]
Length = 415
Score = 112 bits (279), Expect = 2e-24
Identities = 76/244 (31%), Positives = 125/244 (51%), Gaps = 31/244 (12%)
Query: 221 GGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAR 280
GGLD + +I + + + PE E+MG K KG++L GPPG L
Sbjct: 175 GGLDNQIQEI-KESMELPLPHPEYYEEMGTKPPKGVILCGPPGTATFLR----------- 222
Query: 281 EPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR--G 338
V G E++ KY+G+ +R++F AEE I+ DEI+AI +R
Sbjct: 223 ----VVGSELIQKYLGDGPKLVRQVFQVAEEHAPS--------IMFTDEIEAIGTKRYDS 270
Query: 339 SMAGSTGVHDTVVN-QLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
+ G + T++ +LL+++ G + ++ VI T + + +D L+RPGR++ K+E L
Sbjct: 271 NSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHL 330
Query: 398 PDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHI 457
PDEK + I IHT+RM L+ DV + +L + +FSGA+++ + A A+ H
Sbjct: 331 PDEKTKKHIFQIHTSRM----TLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHR 386
Query: 458 KAST 461
+T
Sbjct: 387 MKAT 390
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 106 bits (265), Expect = 7e-23
Identities = 90/263 (34%), Positives = 133/263 (50%), Gaps = 33/263 (12%)
Query: 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGESEANIRKLFADA 309
KG+L+ GPPG GKTLLA+ + A E K V+ + +KY GESE +R LF
Sbjct: 243 KGVLMVGPPGTGKTLLAKAV-----ATECKTTFFNVSSSTLTSKYRGESEKLVRLLF--- 294
Query: 310 EEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGV-------E 362
E R + + I DEID+IC +RG+ + V +LL ++DGV +
Sbjct: 295 --EMARFYSPA---TIFIDEIDSICSRRGT-SEEHEASRRVKAELLVQMDGVGGTSENDD 348
Query: 363 QLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSA 422
++V+ TN P IDEAL R RLE ++ I LP KGR ++L I + L+
Sbjct: 349 PSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELE----LAD 402
Query: 423 DVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEV-DMEKAE-SLQVTRGDF 480
DVD+ +A + +SGA++ + R A AM R I+ T E+ ++ K E + T DF
Sbjct: 403 DVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDF 462
Query: 481 LASLENDIKPAFGTNQEDYASYI 503
+L+ K + E Y +I
Sbjct: 463 EMALKKVSKSVSAADIERYEKWI 485
Score = 35.0 bits (79), Expect = 0.25
Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 533 RTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICS---PDKMIGFSETAKCQAMKKIF 589
R P VL+ GPP +GKT LA +A E F + S K G SE + ++ +F
Sbjct: 239 RRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESE----KLVRLLF 294
Query: 590 DDAYKSQLSCVVVDDIERL 608
+ A + + +D+I+ +
Sbjct: 295 EMARFYSPATIFIDEIDSI 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,069,141
Number of Sequences: 37866
Number of extensions: 1115476
Number of successful extensions: 2965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2687
Number of HSP's gapped (non-prelim): 146
length of query: 744
length of database: 18,247,518
effective HSP length: 110
effective length of query: 634
effective length of database: 14,082,258
effective search space: 8928151572
effective search space used: 8928151572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.