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Search of human proteins with 93102379
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93102379 low density lipoprotein-related protein 1B
precursor [Homo sapiens]
(4599 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93102379 low density lipoprotein-related protein 1B precursor... 9960 0.0
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 5966 0.0
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 2501 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 1080 0.0
gi|148727288 low density lipoprotein receptor-related protein 6 ... 764 0.0
gi|119709832 low density lipoprotein receptor-related protein 5 ... 747 0.0
gi|61744471 low density lipoprotein receptor-related protein 8 i... 536 e-151
gi|65301119 low density lipoprotein receptor-related protein 8 i... 536 e-151
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 520 e-146
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 518 e-146
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 492 e-138
gi|4507157 sortilin-related receptor containing LDLR class A rep... 438 e-122
gi|61744467 low density lipoprotein receptor-related protein 8 i... 431 e-119
gi|66082554 low density lipoprotein receptor-related protein 8 i... 394 e-108
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 227 2e-58
gi|29244926 corin [Homo sapiens] 219 6e-56
gi|134031945 SCO-spondin [Homo sapiens] 196 4e-49
gi|115298674 nidogen 1 precursor [Homo sapiens] 186 6e-46
gi|32698824 low density lipoprotein receptor-related protein 5-l... 161 2e-38
gi|209447022 low density lipoprotein receptor-related protein 5-... 161 2e-38
gi|11415040 matriptase [Homo sapiens] 149 5e-35
gi|144953895 nidogen 2 precursor [Homo sapiens] 148 1e-34
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 142 1e-32
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 138 1e-31
gi|208973262 low density lipoprotein-related protein 12 isoform ... 134 2e-30
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 134 2e-30
gi|134244285 Notch homolog 3 [Homo sapiens] 125 1e-27
gi|148833508 notch1 preproprotein [Homo sapiens] 124 3e-27
gi|55770876 notch4 preproprotein [Homo sapiens] 123 4e-27
gi|24041035 notch 2 preproprotein [Homo sapiens] 120 4e-26
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 9960 bits (25845), Expect = 0.0
Identities = 4599/4599 (100%), Positives = 4599/4599 (100%)
Query: 1 MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD 60
MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD
Sbjct: 1 MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD 60
Query: 61 DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC 120
DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC
Sbjct: 61 DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC 120
Query: 121 QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC 180
QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC
Sbjct: 121 QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC 180
Query: 181 VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF 240
VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF
Sbjct: 181 VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF 240
Query: 241 IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV 300
IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV
Sbjct: 241 IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV 300
Query: 301 DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN 360
DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN
Sbjct: 301 DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN 360
Query: 361 RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT 420
RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT
Sbjct: 361 RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT 420
Query: 421 VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY 480
VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY
Sbjct: 421 VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY 480
Query: 481 GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL 540
GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL
Sbjct: 481 GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL 540
Query: 541 NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN 600
NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN
Sbjct: 541 NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN 600
Query: 601 VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY 660
VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY
Sbjct: 601 VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY 660
Query: 661 WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE 720
WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE
Sbjct: 661 WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE 720
Query: 721 KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP 780
KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP
Sbjct: 721 KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP 780
Query: 781 LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA 840
LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA
Sbjct: 781 LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA 840
Query: 841 LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP 900
LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP
Sbjct: 841 LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP 900
Query: 901 KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA 960
KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA
Sbjct: 901 KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA 960
Query: 961 SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP 1020
SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP
Sbjct: 961 SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP 1020
Query: 1021 GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE
Sbjct: 1021 GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
Query: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK
Sbjct: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
Query: 1141 HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP 1200
HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP
Sbjct: 1141 HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP 1200
Query: 1201 EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA 1260
EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA
Sbjct: 1201 EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA 1260
Query: 1261 FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES 1320
FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES
Sbjct: 1261 FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES 1320
Query: 1321 GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP 1380
GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP
Sbjct: 1321 GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP 1380
Query: 1381 RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV 1440
RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV
Sbjct: 1381 RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV 1440
Query: 1441 WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG 1500
WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG
Sbjct: 1441 WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG 1500
Query: 1501 QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM 1560
QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM
Sbjct: 1501 QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM 1560
Query: 1561 KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL 1620
KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL
Sbjct: 1561 KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL 1620
Query: 1621 YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL 1680
YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL
Sbjct: 1621 YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL 1680
Query: 1681 DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI 1740
DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI
Sbjct: 1681 DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI 1740
Query: 1741 DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL 1800
DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL
Sbjct: 1741 DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL 1800
Query: 1801 GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM 1860
GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM
Sbjct: 1801 GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM 1860
Query: 1861 CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE 1920
CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE
Sbjct: 1861 CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE 1920
Query: 1921 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 1980
NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA
Sbjct: 1921 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 1980
Query: 1981 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA 2040
RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA
Sbjct: 1981 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA 2040
Query: 2041 WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD 2100
WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD
Sbjct: 2041 WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD 2100
Query: 2101 RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY 2160
RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY
Sbjct: 2101 RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY 2160
Query: 2161 RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY 2220
RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY
Sbjct: 2161 RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY 2220
Query: 2221 FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW
Sbjct: 2221 FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
Query: 2281 DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ
Sbjct: 2281 DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
Query: 2341 HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI
Sbjct: 2341 HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
Query: 2401 VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT 2460
VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT
Sbjct: 2401 VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT 2460
Query: 2461 NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN 2520
NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN
Sbjct: 2461 NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN 2520
Query: 2521 GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN 2580
GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN
Sbjct: 2521 GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN 2580
Query: 2581 SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT 2640
SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT
Sbjct: 2581 SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT 2640
Query: 2641 TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI 2700
TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI
Sbjct: 2641 TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI 2700
Query: 2701 CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 2760
CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT
Sbjct: 2701 CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 2760
Query: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 2820
CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 2820
Query: 2821 QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL 2880
QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL
Sbjct: 2821 QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL 2880
Query: 2881 NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ 2940
NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ
Sbjct: 2881 NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ 2940
Query: 2941 DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ 3000
DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ
Sbjct: 2941 DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ 3000
Query: 3001 PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI 3060
PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI
Sbjct: 3001 PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI 3060
Query: 3061 DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY 3120
DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY
Sbjct: 3061 DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY 3120
Query: 3121 PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT 3180
PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT
Sbjct: 3121 PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT 3180
Query: 3181 IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA 3240
IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA
Sbjct: 3181 IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA 3240
Query: 3241 HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC 3300
HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC
Sbjct: 3241 HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC 3300
Query: 3301 PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG 3360
PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG
Sbjct: 3301 PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG 3360
Query: 3361 RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD 3420
RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD
Sbjct: 3361 RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD 3420
Query: 3421 DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE 3480
DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE
Sbjct: 3421 DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE 3480
Query: 3481 FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC 3540
FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC
Sbjct: 3481 FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC 3540
Query: 3541 ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI 3600
ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI
Sbjct: 3541 ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI 3600
Query: 3601 CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD 3660
CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD
Sbjct: 3601 CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD 3660
Query: 3661 GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP 3720
GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP
Sbjct: 3661 GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP 3720
Query: 3721 HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ 3780
HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ
Sbjct: 3721 HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ 3780
Query: 3781 CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR 3840
CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR
Sbjct: 3781 CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR 3840
Query: 3841 QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG 3900
QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG
Sbjct: 3841 QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG 3900
Query: 3901 FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN 3960
FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN
Sbjct: 3901 FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN 3960
Query: 3961 SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR 4020
SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR
Sbjct: 3961 SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR 4020
Query: 4021 LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY 4080
LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY
Sbjct: 4021 LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY 4080
Query: 4081 FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV 4140
FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV
Sbjct: 4081 FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV 4140
Query: 4141 QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK 4200
QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK
Sbjct: 4141 QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK 4200
Query: 4201 YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG 4260
YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG
Sbjct: 4201 YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG 4260
Query: 4261 GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC 4320
GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC
Sbjct: 4261 GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC 4320
Query: 4321 QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC 4380
QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC
Sbjct: 4321 QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC 4380
Query: 4381 NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS 4440
NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS
Sbjct: 4381 NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS 4440
Query: 4441 TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV 4500
TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV
Sbjct: 4441 TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV 4500
Query: 4501 DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP 4560
DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP
Sbjct: 4501 DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP 4560
Query: 4561 VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA 4599
VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA
Sbjct: 4561 VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA 4599
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 5966 bits (15478), Expect = 0.0
Identities = 2747/4650 (59%), Positives = 3392/4650 (72%), Gaps = 178/4650 (3%)
Query: 14 LLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEV 73
LLP+ L A + C P +F C D +TC+S+ W CDG+ DCPD SDE+ + CP+
Sbjct: 9 LLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSK 68
Query: 74 EIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVR 133
+C N CLGT CV +S+LCNGV DC DG DEG HC+EL NC +L CQ+ C
Sbjct: 69 AQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTL 128
Query: 134 NSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
+ CYC F++ DG++CKD DEC+VYGTCSQ C NT GS+ C CVEGYL+QPDNRSC
Sbjct: 129 DGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSC 188
Query: 194 KAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESR 253
KAK EP DRPP+LLIAN + I YL+G++++T++ + + +DF Y + +CW+
Sbjct: 189 KAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVG 248
Query: 254 ESS--NQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCN 311
+S+ QLKC ++ G DE TINI S H+V+QMAIDWLT N YFVD + DRIFVCN
Sbjct: 249 DSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCN 308
Query: 312 SNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQ 371
NG CVTL+DLEL+NPK IA+DP GK+FFTDYG + KVERCDMDG NRT+++DSK
Sbjct: 309 RNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVF 368
Query: 372 PAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNS 431
P + LDLV++LVYW D YLDY+ VVDY+GK R T+IQG + HLYG+TVFE+YLYATNS
Sbjct: 369 PHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNS 428
Query: 432 DNYN------IVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGG 485
DN N ++R+NRFN T+ + +++ + IY +R QP VRSHACE D YG PGG
Sbjct: 429 DNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGG 488
Query: 486 CSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIA 545
CS ICLL++S+K RTCRCR+GF+LGSDG+SCK+P++ELFL YGKGRPGI+RGMD+ K+
Sbjct: 489 CSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVP 548
Query: 546 DEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIA 605
DE+MIPIENL+NPRALDFHAET +IYFADTTS+LIGRQKIDGTERETILKD + NVEG+A
Sbjct: 549 DEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVA 608
Query: 606 VDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWE 665
VDW+G+NLYWT+DG +KTI+VARLEKA+Q+RKTL+EG+M+HPR IVVDP+NGWMYWTDWE
Sbjct: 609 VDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
Query: 666 EDEIDDSVGRIEKAWMDGFNRQIFVTSK-MLWPNGLTLDFHTNTLYWCDAYYDHIEKVFL 724
ED D GR+E+AWMDG +R IFVTSK +LWPNGL+LD LYW DA+YD IE + L
Sbjct: 669 EDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILL 728
Query: 725 NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDL----ITSEVTLLRHERPP 780
NGT RKIVY G ELNH FGL HHGNY+FWT+Y +GS+++L+ VTLLR ERPP
Sbjct: 729 NGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPP 788
Query: 781 LFGLQIYDPRKQQ-GDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGE 839
+F +++YD ++QQ G N CRVNNGGCS+LCLA PG R CACA++Q+LD +G TC NP
Sbjct: 789 IFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSY 848
Query: 840 ALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCI 899
P C+ GEF C N CIQ RWKCDGD+DCLD SDE C H+CP D+FKC+NNRCI
Sbjct: 849 VPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCI 908
Query: 900 PKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEM 959
P RWLCDG NDCG++EDESN TC+ARTC +QFSC +GRCIP +W CD +DDCGD++DE
Sbjct: 909 PNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDES 968
Query: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
ASC +PTC PLTQF C +GRCI+ W CD+D+DCGD SDE GC HSC QF+C+SGRCI
Sbjct: 969 ASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCI 1028
Query: 1020 PGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDC 1079
P HW CDGDNDCGD+SDE NCT + P GC+ +EFQC DG C+P WRCDG+ DC
Sbjct: 1029 PEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDC 1088
Query: 1080 EDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPP 1139
D SDEK C G +CD KF C + RCI+KAWVCDGD DCED SDE++C+S C PP
Sbjct: 1089 MDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPP 1148
Query: 1140 KHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSC 1199
HPCAN+TSVCL P+KLC+G DC DGSDEG LCD+CSLNNGGCS++CSV PG GIVCSC
Sbjct: 1149 SHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSC 1208
Query: 1200 PEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFE 1259
P G++L DN TC+I YC+ HLKCSQ C+Q+K +VKCSCYEGW L+ DGESC S+DPF+
Sbjct: 1209 PLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFK 1268
Query: 1260 AFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319
FIIFS RHEIRRIDLHK DYS+LVPGLRNTIALDFH +QS LYWTDVVED+IYRGKL +
Sbjct: 1269 PFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLD 1328
Query: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEH 1379
+G +++ EVV+++GLATPEGL VDWIAGNIYW++SNLDQIEVAKLDG+LRTTL+AG +EH
Sbjct: 1329 NGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEH 1388
Query: 1380 PRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRI 1439
PRAIALDPR GILFWTDWDA+ PRIE+ASMSGAGR+T++++ +G WPNGLTVD+ EKRI
Sbjct: 1389 PRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRI 1448
Query: 1440 VWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWT 1499
+W DARSDAIYSA YDG+ +E++RGHE+LSHPFAV+LYG EVYWTDWRTNTL+KANKWT
Sbjct: 1449 LWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWT 1508
Query: 1500 GQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHL 1559
G NV+V+Q+T+ QPFDLQ+YHPSRQP APNPC AN G+GPCSH+CLIN+NR+ +CACPHL
Sbjct: 1509 GHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHL 1568
Query: 1560 MKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEER 1619
MKL D TCYE KKFLLYAR+ EIRGVD+D PY+N+I +FTVPDID+VTV+D+DA E+R
Sbjct: 1569 MKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQR 1628
Query: 1620 LYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVAR 1679
+YW+D++TQ IKRAFINGTG+ETV+S D+ + GLAVDWVSRNL+W S + ++ QINVAR
Sbjct: 1629 VYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVAR 1688
Query: 1680 LDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLS 1739
LDGS K +++ G+++P L HP+RGKLYWTDG+ I+MANMDGSN +LF QK PVGL+
Sbjct: 1689 LDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLA 1748
Query: 1740 IDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQ 1799
ID+ E+KLYWISSGN TINRCNLDG LEVI++M+ +L KATAL IM KLWWADQ +
Sbjct: 1749 IDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEK 1808
Query: 1800 LGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQ---QGSNSCQLNNGGCSQLCLPTSETT 1856
+GTCSK DG +LRN T+ V+HMKVYD+ Q +G+N C +NNG CSQLCLPTSETT
Sbjct: 1809 MGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETT 1868
Query: 1857 RTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGID 1916
R+CMCT GY L+ + +C+G+ SFL+YSVHEGIRGIPL+P+DK DAL+P+SGTS AVGID
Sbjct: 1869 RSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGID 1928
Query: 1917 FHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNL 1976
FHAENDTIYW DMG + ISRAKRDQTW+ED++TNG+GRVEGIAVDWIAGNIYWTD GF++
Sbjct: 1929 FHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDV 1988
Query: 1977 IEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVS 2036
IEVARLNGSFRYV+ISQGLD+PR+I VHPEKG LFWTEWGQ P I ++RLDG+E+VVLV+
Sbjct: 1989 IEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048
Query: 2037 MGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYI 2096
+ I+WPNGIS+DY++ KLYWCDARTDKIERIDLETG NRE+VLS +N+DMFSV+VF +I
Sbjct: 2049 VSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFI 2108
Query: 2097 YWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQ 2156
YWSDR HANGS++RG K++AT+++ +RTG+GV LK++K+FNR R+KGTNVCA NGGC+Q
Sbjct: 2109 YWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQ 2168
Query: 2157 LCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYE 2216
LCLYRG +R CACAHG LAEDG +C + GYLLYS RTILKSIHLSDE NLN+P++P+E
Sbjct: 2169 LCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFE 2228
Query: 2217 NPRYFKNVIALAFDYNQRRKGT-----NRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSV 2271
+P + KNVIALAFDY R GT NRIF+SD HFGNIQ I D+ R IVENVGSV
Sbjct: 2229 DPEHMKNVIALAFDY---RAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSV 2285
Query: 2272 EGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNL 2331
EGLAYHR WDTLYWTS TTS+ITRHTVDQTRPGAF+RE VITMS DDHP LDECQNL
Sbjct: 2286 EGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNL 2345
Query: 2332 MFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCE 2391
MFWTNWNEQHPSIMR+ L+G N ++ DI TPNGL ID+RAEKLYFSD +L KIERCE
Sbjct: 2346 MFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCE 2405
Query: 2392 YDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPM 2451
YDGS R+VI+KS P LAVY +IFW+DW RRA+ R+NK+ G + K+LR DIP QPM
Sbjct: 2406 YDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPM 2465
Query: 2452 GIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCN 2511
GIIAVANDTNSCELSPC + NGGC DLCLLT G VNCSCRG RIL +D C NSSC
Sbjct: 2466 GIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCR 2525
Query: 2512 AYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLC 2571
A EFEC NGECI++ LTCDG+PHCKDKSDEK YC +R C++ F+ C N RC+ + C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 2572 DGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
+G +DCGD SDE+ C + C EFRC DGTCI S+RCNQ +DC DASDE NC+ TDC+
Sbjct: 2586 NGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCS 2645
Query: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS 2691
+++LGVK F C TSLC P+W+CDG+NDCGDYSDE CP + +C NYF+CPS
Sbjct: 2646 SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPS 2705
Query: 2692 GRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
GRCI +W CD + DCE G DE HC+ CS QF C +CISK W+CDG DDCGDG DE
Sbjct: 2706 GRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
Query: 2752 SDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFM 2811
+ + C TC FSC G+ CVP WLCDG++DC DG+DE AGC N+TCD+ FM
Sbjct: 2766 A-AHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFM 2824
Query: 2812 CHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC 2871
C N+ CIPK FVCDHD DC DGSDESP+C Y CG EF CA+GRCL + QW+CDG+ DC
Sbjct: 2825 CQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDC 2884
Query: 2872 PDHSDEAPLNPKCKSAEQSCN-SSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINEC 2930
D SDEAP NP C S E CN SS F+C +GRC+ LC+ +DDCGD SDER CHINEC
Sbjct: 2885 HDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINEC 2944
Query: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
LS+K+SGCSQDC+DL + +KC+C PGF+LKDDG+TC D+DECS+ FPCSQ+CINT+G+YK
Sbjct: 2945 LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYK 3004
Query: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
CLC +GY + +P+ CK+++DEEPFLI A+ + +RK++ DGSNYTLLKQGLNN +A+DF
Sbjct: 3005 CLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 3064
Query: 3051 DYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEK 3108
DYRE+ IYW D + GS I RM LNGS+++V+H T + P+ LAVDW+G NLYW D +
Sbjct: 3065 DYREQMIYWTDVT-TQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR 3123
Query: 3109 RIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVV 3168
IEVSKLNG Y T+LVS L+ PR L +D Q GYLYW D ++ IGR+GMDG+++SV+
Sbjct: 3124 DTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 3183
Query: 3169 IETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDY 3226
++TKI+ P LT+DYV R+YWAD E++IEF+++DGS+RH V +QDIP + ALTLFEDY
Sbjct: 3184 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDY 3243
Query: 3227 IYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSH 3286
+YWTD +TKS++RAHKT+G ++ LI + H D+ V+H+ RQPDV H C +NNGGCS+
Sbjct: 3244 VYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSN 3303
Query: 3287 LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGS 3346
LCLL+PG H CACPTNFYL +D RTC+SNCTASQF CK DKCIPFWWKCDT DDCGD S
Sbjct: 3304 LCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHS 3363
Query: 3347 DEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKN 3406
DEP DCPEF+C+PG+FQC TG+C PAFICDG+NDC DNSDE NCD HVCL QFKCT
Sbjct: 3364 DEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNT 3423
Query: 3407 QKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS 3466
+CIP RCNGQD+CGD EDERDCPE +C+P+ FQC TK CI ++WVCD D DC D S
Sbjct: 3424 NRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGS 3483
Query: 3467 DE-ANCDKKTCGPHEFQCKNN-NCIPDHWRCDSQNDCSDNSDE--ENCKPQTCTLKDFLC 3522
DE ANC + TCG EF+CK++ CIP W+CD ++DC D SDE E C +TC F C
Sbjct: 3484 DEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC 3543
Query: 3523 ANGDCVSSRFWCDGDFDCADGSDERNC-ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYG 3581
N CV R+ CD D DC D SDE +C CS+ +F C+NG+CI +WKCDG DC G
Sbjct: 3544 KNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADG 3603
Query: 3582 EDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VTECKEDQFR 3638
DEK C +P C ++ C S CI +C+ + DC DGSDE C V C D+F+
Sbjct: 3604 SDEKDC---TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ 3660
Query: 3639 CKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE-FLCNNSLCKLHFWV---CD 3694
C N C P+ W CDG DC D SDE E +C + F C N ++ W+ CD
Sbjct: 3661 CNNTL-CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKND--RVCLWIGRQCD 3717
Query: 3695 GEDDCGDNSDE---APDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
G D+CGD +DE P C + CRN R CL S CN D+CGD SDE+ C
Sbjct: 3718 GTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQR-CLSSSLRCNMFDDCGDGSDEEDC 3776
Query: 3752 GGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP 3811
I P +C N +
Sbjct: 3777 S---------------------------------------------IDPKLTSCATNASI 3791
Query: 3812 CGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQ 3871
CGD+A C + + + +C C+ GF C+D+NECL FGTCS C N +G + C C +
Sbjct: 3792 CGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCAR 3851
Query: 3872 NFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQ 3931
NF + +NTC AEGSE QVLYIA+D +I ++P + ++Q + + RI MDV+ +
Sbjct: 3852 NFMKTHNTCKAEGSEYQVLYIADDNEIRS-LFPGHPHSAYEQAFQGDESVRIDAMDVHVK 3910
Query: 3932 RDMIIWSTQFNPGGIFYKRI--------HGREKRQANSG---LICPEFKRPRDIAVDWVA 3980
+ W T ++ G I Y+ + R +RQ + G L K PR IA+DWVA
Sbjct: 3911 AGRVYW-TNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVA 3969
Query: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040
GN+YWTD S R I V Q+ G N L++ M EP+AI V+P RG
Sbjct: 3970 GNVYWTD---------------SGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGT 4014
Query: 4041 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLY 4100
MYW+ G+H IE AAMDGTLR LVQ N+Q PTGLAVDY +ER+YWAD +LS+IGS+
Sbjct: 4015 MYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRL 4074
Query: 4101 DGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVEYLALNIDKTK 4159
+G++ +V+ SK+GL HP ID+FEDYIYG N VF++ KFGH + L +
Sbjct: 4075 NGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHAS 4134
Query: 4160 GVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTC--------NDDS 4211
V++ H++KQ ++ NPC CE+LCLL+PSG C CP GK L NGTC D+
Sbjct: 4135 DVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDA 4194
Query: 4212 LLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRP 4271
+C L C NGG C LN + +C C P Y+G++CE++ C +C+NGGTC S G P
Sbjct: 4195 PRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMP 4254
Query: 4272 TCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVN 4331
TC C GFTGP C + VC +C N TC V GNQP C C P + GDRCQY C YC N
Sbjct: 4255 TCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCEN 4314
Query: 4332 SESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSC 4391
+C + DGS +C C +EG +CEV+KC RC G C++NK S D+ CNCT+G++A SC
Sbjct: 4315 FGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSC 4374
Query: 4392 QLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLV 4451
C G+C NGG+C ++ + +P C C + +G +CE + HI+ +I++PL+
Sbjct: 4375 LTCVGHCSNGGSCTMNSKM-MPECQCPPHMTGPRCEEHVFSQQQPGHIA----SILIPLL 4429
Query: 4452 LLVTLITTLVIGLVLCKRKR--RTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGL 4509
LL+ L+ LV G+V ++R K + Q + NG +NVEIGNP+Y MYE + GGL
Sbjct: 4430 LLLLLV--LVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGL 4487
Query: 4510 LDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDG 4569
LD F +DP K PTN++NPVYA LYM G
Sbjct: 4488 LDADFALDPDK---------------------------------PTNFTNPVYATLYMGG 4514
Query: 4570 QNCRNSLGSVDERKELLPKKIEIGIRETVA 4599
R+SL S DE++ELL + E I + +A
Sbjct: 4515 HGSRHSLASTDEKRELLGRGPEDEIGDPLA 4544
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 2501 bits (6482), Expect = 0.0
Identities = 1531/4406 (34%), Positives = 2249/4406 (51%), Gaps = 402/4406 (9%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES-LDTCPEEVEIKCPLNHIACLGTNKC 90
C +F C C+ Q+W+CDG+ DC D+ DE ++ P +V KC +C + +C
Sbjct: 222 CGGYQFTCPSG-RCIYQNWVCDGEDDCKDNGDEDGCESGPHDVH-KCSPREWSCPESGRC 279
Query: 91 VHLSQLCNGVLDCPDGYDE-----GVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFE 145
+ + ++C+G+LDCP DE G +C L C LNCQY+C C+C G+
Sbjct: 280 ISIYKVCDGILDCPGREDENNTSTGKYCSMTL--CSALNCQYQCHETPYGGACFCPPGYI 337
Query: 146 ITE-DGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
I D R+C + D+C ++G C Q C + G + C C EGY+++ + CKA +
Sbjct: 338 INHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEAS- 395
Query: 205 ILLIANFETIEVFYLNGSKMATL-SSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQ 263
++ +N + + ++G L S N + F Y+ + W ++ + N++ +
Sbjct: 396 -IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQ--NKVFSVD 452
Query: 264 ITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDL 323
I GL + +N+ S + +A+DW+ +Y V+ +RI + N +GS VTLI
Sbjct: 453 IN---GLNIQEVLNV--SVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITE 507
Query: 324 ELHNPKAIAVDPIAGKLFFTDYGNVA---KVERCDMDGMNRTRIIDSKTEQPAALALDLV 380
L +P+ IAVDP G LFF+D+ +++ K+ER MDG NR ++ +K PA + LD++
Sbjct: 508 NLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMI 567
Query: 381 NKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRI 439
+K VYWVD DY+ V Y G R TV+ G + H +G+++FE ++ T+ +++
Sbjct: 568 SKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKA 627
Query: 440 NRFNGTDIHSLIKIE-NAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKT 498
N+F T+ + +G+ +Y QP ++ C+ + GGC +C+LS
Sbjct: 628 NKFTETNPQVYYQASLRPYGVTVYHSLRQPYA-TNPCKDNN----GGCEQVCVLSHRTDN 682
Query: 499 R----TCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIEN 554
C+C GF L +D R C +N FL + +RG+ ++ M+P+
Sbjct: 683 DGLGFRCKCTFGFQLDTDERHCIAVQN--FLIFSS--QVAIRGIPFTLSTQEDVMVPVSG 738
Query: 555 LVNPR---ALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611
NP +DF A+ + I+F+D + +I +QKIDGT RE + + ++NVE +A DWI
Sbjct: 739 --NPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISK 796
Query: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDD 671
NLYWT D H K+I+V RL A ++R+T+++ +++PR +VV P G++++TDW
Sbjct: 797 NLYWT-DSHYKSISVMRL--ADKTRRTVVQ-YLNNPRSVVVHPFAGYLFFTDWFRP---- 848
Query: 672 SVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKI 731
+I +AW DG + + + + WPNGL +D+ + LYW DAY+D IE +G R+
Sbjct: 849 --AKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRR 906
Query: 732 VYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS-EVTLLRHERPPLFGLQIYDPR 790
+ ++ HPFGL+ G ++F+TD+ G+I ++ E+T++R + L+ YD
Sbjct: 907 LGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVN 966
Query: 791 KQQGDNMCRVN---NGGCSTLCLAIPG-GRVCACADNQLLDENGTTCTFNPGEALP-HIC 845
Q G N C NG CS C +P RVC C L N TC +P P C
Sbjct: 967 IQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQC 1026
Query: 846 KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLC 905
F CKN C+ + CDG DDC D SDE N++C F C + CIP W C
Sbjct: 1027 GLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRC 1086
Query: 906 DGANDCGSNEDESN-QTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEF 964
D NDC DE N T +C Q++C N +CI + W+CD ++DCGD +DE
Sbjct: 1087 DKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNST 1146
Query: 965 PTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSG-RCIPGHW 1023
TC+P +QF C + RCI + CD D DC DGSDEVGCV +C +QF+C+SG +CI
Sbjct: 1147 ETCQP-SQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTN 1205
Query: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
CDG DC D SDEA C P C+ +EFQC DG C+P+ W CDG DC GS
Sbjct: 1206 RCDGVFDCSDNSDEA--GCPTRP---PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS 1260
Query: 1084 DEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS--FLCGPPKH 1141
DE N + + F C G CI++AW+CD D DC D SDE DC + F C +
Sbjct: 1261 DEH--NACVPKTCPSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
Query: 1142 PCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCD--ECSLNNGGCSNHCSVVPGRGIVCSC 1199
C ++C+ +C+G DCP+G+DE LC+ CS NGGC++ C P G C C
Sbjct: 1318 QCLGH-NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPF-GAKCLC 1375
Query: 1200 PEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFE 1259
P G L D+KTCE +D C CSQ C + + +CSC G+ L+ DG +C
Sbjct: 1376 PLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASES 1435
Query: 1260 AFIIFSIRHEIRRIDLHKRDYSL--LVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKL 1317
++ + +++I + + +++ LV +A+DF ++W+D + + +
Sbjct: 1436 LLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTW---- 1491
Query: 1318 SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAM 1377
S + VV + + E + +DW+ N+YW D L+ IEV+K+DGS RT LI+ +
Sbjct: 1492 SAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNL 1551
Query: 1378 EHPRAIALDPRYG--ILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHF 1435
+PR +ALDPR +LFW+DW + PRIE ASM G+ R I +D WP GLT+D+
Sbjct: 1552 TNPRGLALDPRMNEHLLFWSDW-GHHPRIERASMDGSMRTVIVQDKIF--WPCGLTIDYP 1608
Query: 1436 EKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKA 1495
+ + + D+ D + Y+G + ++I + HP+A++L+ VYWTD T + +A
Sbjct: 1609 NRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRA 1668
Query: 1496 NKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHN--RSAA 1553
NKW G N SV+ P + HPS+QP + NPCA + CSH+CL++ +
Sbjct: 1669 NKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCLLSSQGPHFYS 1724
Query: 1554 CACPHLMKLSSDKKTCY-EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVID 1612
C CP LS D C + + FL+ R+ I G+ ++ + + I + ++
Sbjct: 1725 CVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVE 1784
Query: 1613 FDASEERLYWTDIKTQTIKRAFINGTGLETVISRD-IQSIRGLAVDWVSRNLYWISSEFD 1671
FD +E+ +YW + + I R +GT S + LA+DW+SRNLY S+
Sbjct: 1785 FDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY--STNPR 1841
Query: 1672 ETQINVARLDGSL---KTSIIH-----GIDKPQCLAAHPVRGKLYWTDGNT-------IN 1716
I V L G + KT I + G+ P + P RGKLYW+D T I
Sbjct: 1842 TQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIA 1901
Query: 1717 MANMDGSNSKILFQNQKEPVG-LSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKE 1775
ANMDG++ K LF E + +++D E KLYW +G G I R N+DG + ++
Sbjct: 1902 SANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV---H 1958
Query: 1776 ELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKE-AQQG 1834
+L+ + + D L++ D+ + K G N +LR+ + ++VY + A +
Sbjct: 1959 QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAES 2018
Query: 1835 SNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPL 1894
SN C N C Q+CLP +C C G+ L + SC SF++ S+ IRG L
Sbjct: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSL 2078
Query: 1895 EPSDKMDALMPISGTSF-AVGIDFHAENDTIYWTDMGF-----NKISRAKRDQTWKEDII 1948
E SD + ++P++G A+ +D + IYW D N I R K D + +I+
Sbjct: 2079 ELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIV 2138
Query: 1949 TNGLGR--VEGIAVDWIAGNIYWTDHGFN--LIEVARLNGSFRYVIISQGLDQPRSIAVH 2004
T+G+G V GIAVDW+AGN+Y+T+ + LIEV R+N ++R V++ +D PR I V
Sbjct: 2139 THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVD 2198
Query: 2005 PEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKI 2064
P+ LFW ++GQ P I ++ LD + + VLVS GI P G+++D + +YW D D I
Sbjct: 2199 PKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDII 2258
Query: 2065 ERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMR 2123
RI + G N E++ GS + + VF I W DR + + + + TE T+
Sbjct: 2259 ARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDR-NLKKIFQASKEPENTEPPTVI 2316
Query: 2124 TGLGVNLKEVKIFNRV------REKGTNVCARDNGGCKQLCL-YRGNSRRTCACAHGYLA 2176
L++V IF++ E N C +NGGC LC G C CA G L
Sbjct: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQ 2376
Query: 2177 EDGVTC-LRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRR 2235
DG C + E +L+++ L+S+HL E + SP P++ + V++L +D
Sbjct: 2377 SDGKNCAISTENFLIFALSNSLRSLHLDPENH--SP--PFQTINVERTVMSLDYD----- 2427
Query: 2236 KGTNRIFYSD---AHFGNIQL--IKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTT 2290
++RI+++ + G I + VI +G+ +G+A+ +Y++
Sbjct: 2428 SVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLN 2487
Query: 2291 SSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLT 2350
I D + +R + + + P + LD CQ ++W +W + H I R+TL
Sbjct: 2488 QMINSMAEDGS-----NRTVIARVPK---PRAIVLDPCQGYLYWADW-DTHAKIERATLG 2538
Query: 2351 GKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS 2410
G +V++ ++ P+GLT+DY + LY+ D SL +IER G R VIV + F
Sbjct: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF-G 2597
Query: 2411 LAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGI-IAVANDTNSCELSPCA 2469
L +Y YI+W+D + I R+NKY G + +++ QP GI V N C +PC
Sbjct: 2598 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCN-NPCE 2656
Query: 2470 LLNGGCHDLCLLTPNGRVNCSCRGD-RILLEDNR--CVTKNSSCNAYSEFECGNGECIDY 2526
NGGC +C PNG C C + L +NR C+ N S F C NG CI
Sbjct: 2657 QFNGGCSHICAPGPNG-AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISE 2715
Query: 2527 QLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC 2586
+ CD C D SDE C +C C N RC+ + CD NDCGD SDE C
Sbjct: 2716 EWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Query: 2587 KVSTC-ATVEFRCADGTCIPRSARCNQNIDCAD--ASDEKNCNNTDCTHFYKLGVKTTGF 2643
C AT EF C + CIPR CN +C D SDEKNC + C +G+
Sbjct: 2776 LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQ---------SGY 2826
Query: 2644 IRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDG 2703
+C+++++C+ ++CDG NDCGD SDE H C + F C SGRCI W CD
Sbjct: 2827 TKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQ 2885
Query: 2704 QKDCEDGRDE----FHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI-CGA 2758
+ DC D DE H + +C ++F C +CI WICDG++DCGD DE C
Sbjct: 2886 ETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN 2945
Query: 2759 ITCAADMFSCQGSRA----CVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
C+ F C R C+P+ W+CDG+ DC DG DE C TC EN F C
Sbjct: 2946 QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE--NQNCT-RRTCSENEFTCGY 3002
Query: 2815 KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDH 2874
+CIPK F CD +DCGD SDE C Y+ C +F+C +GRC+ T + CD D DC D
Sbjct: 3003 GLCIPKIFRCDRHNDCGDYSDERG-CLYQTCQQNQFTCQNGRCISKT-FVCDEDNDCGDG 3060
Query: 2875 SDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKK 2934
SDE L C + E +C F C NGRCI LC++ DDC D SDE+ C INEC
Sbjct: 3061 SDE--LMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPS 3118
Query: 2935 VSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSS-GFPCSQQCINTYGTYKCLC 2993
+SGC +C D S+ C C PG++L D +TCVDIDEC+ F CSQ+C N G+Y C C
Sbjct: 3119 ISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKC 3178
Query: 2994 TDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYR 3053
GY +PD C+ S+ EP+LI ++ + +R ++ DG Y+L+ +GL+NV+A+DFD
Sbjct: 3179 APGYLREPDGKT-CRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRV 3237
Query: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA--LAVDWIGKNLYWSDTEKRII 3111
E+ +YWID+ R I RM LN ++ + + N +P A LAVDW+ + LYW D +
Sbjct: 3238 EKRLYWIDTQR---QVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGL 3294
Query: 3112 EVSKLNGLYPTILVSKRLKF--------PRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGT 3163
VS LNG + +L + PR L+L PQ GYLYW D +IGRVGMDGT
Sbjct: 3295 FVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGT 3354
Query: 3164 NQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRHKVPNQDIPGVIALT 3221
N+SV+I TK+ P +TIDY N LYWAD + +IE+S+++G HRH V + +P A+T
Sbjct: 3355 NKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAIT 3414
Query: 3222 LFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINN 3281
+FED IYWTD T+++ + +K G++R +L+ + H DI VYH YRQP VS + C NN
Sbjct: 3415 IFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVS-NPCGTNN 3473
Query: 3282 GGCSHLCLLAP-GKTHTCACPTNF--YLAADNRTCLSNCTASQFRC-KTDKCIPFWWKCD 3337
GGCSHLCL+ P GK TC CP +F + + C+ C+++QF C +KCIP WWKCD
Sbjct: 3474 GGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCD 3533
Query: 3338 TVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDE--LNCDTHV 3395
DC DGSDE CP+ C+ G+FQC G C P +C+ +C D SDE L C+ H
Sbjct: 3534 GQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH 3593
Query: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGD--EEDERDCPENSCSPDYFQ----------- 3442
C S +++C N++CIP + +C+ +DC D +ED C +C P F+
Sbjct: 3594 CDSNEWQCA-NKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAW 3652
Query: 3443 ---------------------------------CKTTKHCISKLWVCDEDPDCADASDEA 3469
CKT CI K VC+ DC D SDE
Sbjct: 3653 KCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
Query: 3470 NCDKKTCGP-HEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCV 3528
C+++TC P +F+CKN++CIP W+CD QNDC DNSDEENC P+ CT +F C N C+
Sbjct: 3713 GCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCI 3772
Query: 3529 SSRFWCDGDFDCADGSDERNCE-TSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC 3587
SR+ CD DC D SDER+CE +C + F+C++G C+ ++ KCDG DC DE C
Sbjct: 3773 PSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Query: 3588 E---PASPTCSSREYICASDGCISASLKCNGEYDCADGSDE---MDCVTECKE-DQFRCK 3640
P C + + C + CI KC+G+ DC DGSDE + C ++FRC
Sbjct: 3833 PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD 3892
Query: 3641 NKAHCIPIRWLCDGIHDCVDGSD--EENCER-GGNICRADEFLCNNSLCKLHFWVCDGED 3697
N CI +C+G+ DC DG+D EE+C + C E+ C N C H VCD D
Sbjct: 3893 NN-RCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDAD 3951
Query: 3698 DCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTY 3757
DCGD SDE C + C N IC EQ C ++E GG +
Sbjct: 3952 DCGDWSDELG-------CNKGKERTCAEN-IC---EQNCTQLNE----------GGFICS 3990
Query: 3758 KARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY 3817
+ + F C+ ++ +C++ C +
Sbjct: 3991 CTAGFETNVF--DRTSCLDIN-ECEQFGTC---------------------------PQH 4020
Query: 3818 CNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERN 3877
C K S C C GF +M +R
Sbjct: 4021 CRNTKGSYECVCADGF-TSMSDRP-----------------------------------G 4044
Query: 3878 NTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIW 3937
C AEGS +L N I +N S E S + Y Q W
Sbjct: 4045 KRCAAEGSSPLLLLPDNVR-----IRKYNLSS--------ERFSEYLQDEEYIQAVDYDW 4091
Query: 3938 STQFNPGGIFYKRIHGREKR-QANSGLICPEFKRPRDIAVDWVAGNIYWT---DHSRMHW 3993
+ + Y + G R A P F+ R+ V V + + D + W
Sbjct: 4092 DPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDW 4151
Query: 3994 FSYYTTHWTSLRYS-INVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHI 4052
+ +W+ ++ I V +L+G L++ +P AIAVNPK G+M+WT G I
Sbjct: 4152 VGRH-IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKI 4210
Query: 4053 EEAAMDGTLRRILVQKNLQRPTGLAVDYF-SERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
E A M+G R ILV ++L PTGL++DY ++RIYW+DF+ +I ++ YDG++ V
Sbjct: 4211 ESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKE 4270
Query: 4112 KQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSVEYLALNIDKTKGVLISHRYK-Q 4169
++P+ +DIFED +Y + G V++ KFG G E + V I H+ +
Sbjct: 4271 ---AMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYN 4327
Query: 4170 LDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCND-DSLLDDSCKL----TCENG 4224
+PN C + C LCLL P G +C CP+G I G+ + D+ ++ L C +G
Sbjct: 4328 KSVPNLCKQI-CSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHG 4386
Query: 4225 GRCILNEKGDLRCHCWPSYSGERCEV 4250
G C +E +C C Y+G+ CE+
Sbjct: 4387 GNCYFDETDLPKCKCPSGYTGKYCEM 4412
Score = 639 bits (1647), Expect = 0.0
Identities = 364/1065 (34%), Positives = 540/1065 (50%), Gaps = 110/1065 (10%)
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQN-NRCIPKRW 903
C + FRC + HCI A W+CDG DC D D D + C +C FKCQ+ +CIP W
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSD--DADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 904 LCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCE 963
+CD DC DE Q C+ TC Q +C NG+CIP + CD DC D DE C+
Sbjct: 86 VCDQDQDCDDGSDE-RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADE-NDCQ 143
Query: 964 FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHW 1023
+PTCE LT C +G C ++ CD DC D SDE+ C C N+F C +G CIP +
Sbjct: 144 YPTCEQLT---CDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAY 200
Query: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
CD DNDC D SDE N C G +F C P G C+ W CDGE DC+D
Sbjct: 201 VCDHDNDCQDGSDEHACNYPT--------CGGYQFTC-PSGRCIYQNWVCDGEDDCKDNG 251
Query: 1084 DEKGCNG---TIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
DE GC + C + ++SC +GRCI+ VCDG +DC + DE
Sbjct: 252 DEDGCESGPHDVHKCSPR-EWSCPESGRCISIYKVCDGILDCPGREDE------------ 298
Query: 1141 HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP 1200
N+TS G C + C C P G C CP
Sbjct: 299 ----NNTST--------------------GKYCSMTLCSALNCQYQCHETPYGG-ACFCP 333
Query: 1201 EGLQLN-KDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPF- 1258
G +N D++TC D C C Q CE C C EG+ L+ G+ C + D F
Sbjct: 334 PGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILE-RGQYCKANDSFG 392
Query: 1259 EAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD--FHFNQSLLYWTDVVEDRIYRGK 1316
EA IIFS ++ D+H R + +LV +A+ FH++ ++WTD V+++++
Sbjct: 393 EASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVD 452
Query: 1317 LSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGA 1376
++ G++ I+ V+ + TPE L VDW+ IY +++ +++I++ LDGS R TLI
Sbjct: 453 IN---GLN-IQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
Query: 1377 MEHPRAIALDPRYGILFWTDWD--ANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDH 1434
+ HPR IA+DP G LF++DW+ + P++E A M G+ RK + K K G WP G+T+D
Sbjct: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVK-TKLG-WPAGVTLDM 566
Query: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494
KR+ W D+R D I + YDG ++ G + HPF VSL+ +V++TDW + K
Sbjct: 567 ISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLK 626
Query: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNR---- 1550
ANK+T N V + S +P+ + +YH RQP A NPC D G C +C+++H
Sbjct: 627 ANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPC--KDNNGGCEQVCVLSHRTDNDG 684
Query: 1551 -SAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVT 1609
C C +L +D++ C ++ FL+++ + IRG+ FT+ +DV
Sbjct: 685 LGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGI-----------PFTLSTQEDVM 733
Query: 1610 V-----------IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDW 1658
V IDFDA + ++++D+ I + I+GTG E + + ++++ LA DW
Sbjct: 734 VPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDW 793
Query: 1659 VSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTI 1715
+S+NLYW S + I+V RL + +++ ++ P+ + HP G L++TD I
Sbjct: 794 ISKNLYWTDSHY--KSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKI 851
Query: 1716 NMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMK 1774
A DGS+ ++ P GL+ID+ ++LYW+ + I DG + + +
Sbjct: 852 MRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHI- 910
Query: 1775 EELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQG 1834
E++T L I + L++ D L + K DG T++R+ + ++H+K YD Q G
Sbjct: 911 EQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTG 970
Query: 1835 SNSCQL---NNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQG 1876
SN+C NG CS C P R C C G L N ++C+G
Sbjct: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEG 1015
Score = 386 bits (991), Expect = e-106
Identities = 270/864 (31%), Positives = 406/864 (46%), Gaps = 85/864 (9%)
Query: 27 RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES----LDTCPEEV--------- 73
R +C EF C + C+ W CDG PDC SDE TCP
Sbjct: 1225 RPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCI 1284
Query: 74 ------------------------EIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDE 109
+CP CLG N CV+LS +C+G+ DCP+G DE
Sbjct: 1285 HRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Query: 110 GVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQ 167
C ++C N C ++C +C C GF + D ++C+D DEC + G+CSQ
Sbjct: 1345 SPLCNG--NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQ 1402
Query: 168 TCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATL 227
C N GS+ CSC GY+++ D R+CK +LL+A+ I +
Sbjct: 1403 HCYNMRGSFRCSCDTGYMLESDGRTCKV---TASESLLLLVASQNKIIADSVTSQVHNIY 1459
Query: 228 SSV-NGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQ 286
S V NG+ I +DF I W ++ + T + D S +
Sbjct: 1460 SLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFD-------SSIILTE 1512
Query: 287 QMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGK--LFFTD 344
+AIDW+ RNLY+ D+ + I V +GS LI L NP+ +A+DP + LF++D
Sbjct: 1513 TIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSD 1572
Query: 345 YGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNR 404
+G+ ++ER MDG RT I+ K P L +D N+L+Y++D YLDY+ DY G +R
Sbjct: 1573 WGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHR 1632
Query: 405 HTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW--GIRI 461
VI +RH Y +T+FED +Y T+ ++R N+++G + S++ W GI
Sbjct: 1633 RQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGN-QSVVMYNIQWPLGIVA 1691
Query: 462 YQKRTQPTVRSHACEVDPYGMPGGCSHICLLSS-SYKTRTCRCRTGFNLGSDGRSCKRPK 520
QP V+P CSH+CLLSS +C C +G++L D +C R
Sbjct: 1692 VHPSKQPN------SVNPCAF-SRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDD 1744
Query: 521 NELFLFYGKGRPGIVRGMDLNTKI-ADEYMIPIENLVNPRALDFHAETNYIYFADTTSFL 579
+ R I+ G+ LN ++ +++ M+PI + N ++F YIY+ +
Sbjct: 1745 QPFLITV---RQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG-E 1800
Query: 580 IGRQKIDGTERETILKDDLDNVE-GIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
I R K DGT R + +A+DWI NLY TN ++I V L + RKT
Sbjct: 1801 IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNP-RTQSIEVLTLHGDIRYRKT 1859
Query: 639 LLEGE-----MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSK 693
L+ + + P GI VDP G +YW+D D +I A MDG + + T
Sbjct: 1860 LIANDGTALGVGFPIGITVDPARGKLYWSDQGTD--SGVPAKIASANMDGTSVKTLFTGN 1917
Query: 694 MLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFW 753
+ +TLD LYW IE+ ++GT R I+ +L+HP+G++ H +++++
Sbjct: 1918 LEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV--HQLSHPWGIAVHDSFLYY 1975
Query: 754 TDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRK-QQGDNMCRVNNGGCSTLCLA 811
TD I ++D T + +LR P L GLQ+Y R + N C N C +CL
Sbjct: 1976 TDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLP 2035
Query: 812 IPGGRV-CACADNQLLDENGTTCT 834
+PGG CACA L+ + +C+
Sbjct: 2036 VPGGLFSCACATGFKLNPDNRSCS 2059
Score = 348 bits (893), Expect = 7e-95
Identities = 226/787 (28%), Positives = 360/787 (45%), Gaps = 127/787 (16%)
Query: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRC-ADGTCIPRSA 2608
+ C C + CIP CDG DC D++DE+ C V TC F+C ++G CIP S
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 2609 RCNQNIDCADASDEK-NCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGD 2667
C+Q+ DC D SDE+ +C+ + C+ I C S C+ + CD DC D
Sbjct: 86 VCDQDQDCDDGSDERQDCSQSTCSSHQ---------ITC-SNGQCIPSEYRCDHVRDCPD 135
Query: 2668 YSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFAC 2727
+DE C CE+ +C +G C + CD + DC D DE +C C N+F+C
Sbjct: 136 GADENDCQYPT---CEQ--LTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSC 190
Query: 2728 SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDC 2787
+CI + ++CD ++DC DG DE C TC F+C R C+ ++W+CDGE DC
Sbjct: 191 GNGECIPRAYVCDHDNDCQDGSDE--HACNYPTCGGYQFTCPSGR-CIYQNWVCDGEDDC 247
Query: 2788 PDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGT 2847
D DE DG + P +C
Sbjct: 248 KDNGDE--------------------------------------DGCESGPH-DVHKCSP 268
Query: 2848 EEFSCAD-GRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPS 2906
E+SC + GRC ++ CDG DCP DE
Sbjct: 269 REWSCPESGRC-ISIYKVCDGILDCPGREDE----------------------------- 298
Query: 2907 GGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLK-DDGKT 2965
+ S + C + C C C + P C C PG+ + +D +T
Sbjct: 299 ----------NNTSTGKYCSMTLC---SALNCQYQCHETPYGGACFCPPGYIINHNDSRT 345
Query: 2966 CVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSL-SDEEPFLILADHHE 3024
CV+ D+C C Q+C + G + C C +GY + + CK+ S E +I ++ +
Sbjct: 346 CVEFDDCQIWGICDQKCESRPGRHLCHCEEGYIL--ERGQYCKANDSFGEASIIFSNGRD 403
Query: 3025 IRKISTDGSNYTLLKQGLNNVIAID--FDYREEFIYWIDSSRPNGSRINRMCLNGSDIKV 3082
+ G ++ +L + N +A+ F Y + ++W D+ + +++ + +NG +I+
Sbjct: 404 LLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQ---NKVFSVDINGLNIQE 460
Query: 3083 VHNTAV--PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQ 3140
V N +V P LAVDW+ +Y +T+ I++ L+G Y L+++ L PR +++DP
Sbjct: 461 VLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPT 520
Query: 3141 AGYLY---WIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NH 3195
GYL+ W P + R MDG+N+ +++TK+ P +T+D +++R+YW D ++
Sbjct: 521 VGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDY 580
Query: 3196 IEFSNMDGSHRHKVPNQD--IPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 3253
IE DG R V + IP ++LFE +++TD ++ +A+K + +
Sbjct: 581 IETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQ 640
Query: 3254 SWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLA-----PGKTHTCACPTNFYLAA 3308
+ + VYHS RQP + + C NNGGC +C+L+ G C C F L
Sbjct: 641 ASLRPYGVTVYHSLRQP-YATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDT 699
Query: 3309 DNRTCLS 3315
D R C++
Sbjct: 700 DERHCIA 706
Score = 298 bits (762), Expect = 1e-79
Identities = 211/711 (29%), Positives = 318/711 (44%), Gaps = 66/711 (9%)
Query: 3513 QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCET-SCSKDQFRC-SNGQCIPAKW 3570
Q C F C +G C+ + + CDG DC+D +DE C +C + F+C S GQCIP W
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 3571 KCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVT 3630
CD +DC G DE+ + + TCSS + C++ CI + +C+ DC DG+DE DC
Sbjct: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQY 144
Query: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
E Q C N A C CD DC D SDE NC IC +EF C N C
Sbjct: 145 PTCE-QLTCDNGA-CYNTSQKCDWKVDCRDSSDEINCTE---ICLHNEFSCGNGECIPRA 199
Query: 3691 WVCDGEDDCGDNSDEAP---DMC--VKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDN 3745
+VCD ++DC D SDE C +F CPS R C+ +C+G D+C DN
Sbjct: 200 YVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGR---------CIYQNWVCDGEDDCKDN 250
Query: 3746 SDEDHCGGKLTYKARPCKKDEFACSNK-KCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYT 3804
DED C + C E++C +CI + CD + DC DE +Y
Sbjct: 251 GDEDGCESG-PHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTG--KYC 307
Query: 3805 CEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKN-RQCEDLNECLVFGTCSHQCINVEG 3863
+ C++ C C PG+ N + R C + ++C ++G C +C + G
Sbjct: 308 SMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPG 367
Query: 3864 SYKCVCDQNF-QERNNTCIAEGSEDQVLYI-ANDTDIL-GFIYPFNYSGDHQQISHIEHN 3920
+ C C++ + ER C A S + I +N D+L G I+ ++ + + ++
Sbjct: 368 RHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSF----RILVESQNR 423
Query: 3921 SRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVA 3980
G+ +Y + W T +F I+G ++ ++ + P ++AVDWV
Sbjct: 424 GVAVGVAFHYHLQRVFW-TDTVQNKVFSVDINGLNIQE----VLNVSVETPENLAVDWVN 478
Query: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040
IY + T + I++ L+G L+T G P IAV+P G
Sbjct: 479 NKIYLVE--------------TKVN-RIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGY 523
Query: 4041 MY---WTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGS 4097
++ W + +E A MDG+ R+ LV+ L P G+ +D S+R+YW D I +
Sbjct: 524 LFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIET 583
Query: 4098 VLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVEYLALNID 4156
V YDG V + HP + +FE ++ K V + KF + +
Sbjct: 584 VTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASL 643
Query: 4157 KTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPS------GATCVCPEG 4199
+ GV + H +Q NPC D CE +C+L+ G C C G
Sbjct: 644 RPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFG 694
Score = 222 bits (566), Expect = 6e-57
Identities = 124/354 (35%), Positives = 166/354 (46%), Gaps = 38/354 (10%)
Query: 3357 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRC 3416
C F+CG+G C + CDG DC D++DE+ C C G FKC +CIP + C
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87
Query: 3417 NGQDDCGDEEDER-DCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT 3475
+ DC D DER DC +++CS C + CI + CD DC D +DE +C T
Sbjct: 88 DQDQDCDDGSDERQDCSQSTCSSHQITC-SNGQCIPSEYRCDHVRDCPDGADENDCQYPT 146
Query: 3476 CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCD 3535
C + C N C +CD + DC D+SDE NC + C +F C NG+C+ + CD
Sbjct: 147 C--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAYVCD 203
Query: 3536 GDFDCADGSDERNCE-TSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPAS--- 3591
D DC DGSDE C +C QF C +G+CI W CDG +DCK DE CE
Sbjct: 204 HDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDV 263
Query: 3592 PTCSSREYICASDG-CISASLKCNGEYDCADGSDEMD-------CVTECKEDQFRCKNKA 3643
CS RE+ C G CIS C+G DC DE + +T C C+ +
Sbjct: 264 HKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLC--SALNCQYQC 321
Query: 3644 HCIPIRWLC----------DGIHDCVDGSD-------EENCER--GGNICRADE 3678
H P C + CV+ D ++ CE G ++C +E
Sbjct: 322 HETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEE 375
Score = 209 bits (533), Expect = 4e-53
Identities = 115/330 (34%), Positives = 165/330 (50%), Gaps = 33/330 (10%)
Query: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR-RCIPHGKLCD 2572
+ F CG+G CI CDG C D +DE + C +C++G+ C + +CIP+ +CD
Sbjct: 31 AHFRCGSGHCIPADWRCDGTKDCSDDADE--IGCAVVTCQQGYFKCQSEGQCIPNSWVCD 88
Query: 2573 GENDCGDNSDE-LDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
+ DC D SDE DC STC++ + C++G CIP RC+ DC D +DE +C C
Sbjct: 89 QDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148
Query: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS 2691
+ C++ C + CD DC D SDE+ C C N FSC +
Sbjct: 149 Q-----------LTCDN-GACYNTSQKCDWKVDCRDSSDEINC----TEICLHNEFSCGN 192
Query: 2692 GRCILNTWICDGQKDCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLD 2750
G CI ++CD DC+DG DE C+ +C QF C + +CI ++W+CDGEDDC D D
Sbjct: 193 GECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252
Query: 2751 ESDSICG---AITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAG---CAPNNT 2804
E G C+ +SC S C+ + +CDG DCP DE +T+ C+
Sbjct: 253 EDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLC 312
Query: 2805 CDENA-FMCHNK----VCI-PKQFVCDHDD 2828
N + CH C P ++ +H+D
Sbjct: 313 SALNCQYQCHETPYGGACFCPPGYIINHND 342
Score = 207 bits (527), Expect = 2e-52
Identities = 135/383 (35%), Positives = 177/383 (46%), Gaps = 42/383 (10%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC-GTGLCALPAFI 3375
C ++ FRC + CIP W+CD DC D +DE C CQ G F+C G C +++
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADE-IGCAVVTCQQGYFKCQSEGQCIPNSWV 86
Query: 3376 CDGENDCGDNSDE-LNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPEN 3434
CD + DC D SDE +C C S Q C+ N +CIP RC+ DC D DE DC
Sbjct: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITCS-NGQCIPSEYRCDHVRDCPDGADENDCQYP 145
Query: 3435 SCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWR 3494
+C + C C + CD DC D+SDE NC + C +EF C N CIP +
Sbjct: 146 TC--EQLTCDNGA-CYNTSQKCDWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAYV 201
Query: 3495 CDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCET--- 3551
CD NDC D SDE C TC F C +G C+ + CDG+ DC D DE CE+
Sbjct: 202 CDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPH 261
Query: 3552 ---SCSKDQFRC-SNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCI 3607
CS ++ C +G+CI CDG DC EDE + CS +C++ C
Sbjct: 262 DVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTS-TGKYCSMT--LCSALNC- 317
Query: 3608 SASLKCN-----GEYDCADG-----SDEMDCVTECKEDQF--RCKNKAHCIPIRWLCDGI 3655
+C+ G C G +D CV E + Q C K P R LC
Sbjct: 318 --QYQCHETPYGGACFCPPGYIINHNDSRTCV-EFDDCQIWGICDQKCESRPGRHLC--- 371
Query: 3656 HDCVDGSDEENCERGGNICRADE 3678
C +G E G C+A++
Sbjct: 372 -HCEEGYILER----GQYCKAND 389
Score = 186 bits (473), Expect = 4e-46
Identities = 148/545 (27%), Positives = 233/545 (42%), Gaps = 80/545 (14%)
Query: 28 DQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGT 87
D C F C +HV C+ W CDGD DC D SDE L C +++ C +
Sbjct: 3838 DGAYCQATMFECKNHV-CIPPYWKCDGDDDCGDGSDEELHLC---LDVPCNSPNRFRCDN 3893
Query: 88 NKCVHLSQLCNGVLDCPDGYDEGV-HCQ-------------------------------- 114
N+C++ ++CNGV DC DG DE HC+
Sbjct: 3894 NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDC 3953
Query: 115 -----ELLSN------CQQLNCQYKCTMVRNSTR-CYCEDGFEITE-DGRSCKDQDECAV 161
EL N C + C+ CT + C C GFE D SC D +EC
Sbjct: 3954 GDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQ 4013
Query: 162 YGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNG 221
+GTC Q CRNT GSY C C +G+ D + E + P+LL+ + I + L+
Sbjct: 4014 FGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSS--PLLLLPDNVRIRKYNLSS 4071
Query: 222 SKMATLSSVNGNEIHTLDFIYNED----MICWIESRESSNQLKCIQ-------ITKAGGL 270
+ + + I +D+ ++ + + R ++ I+ + L
Sbjct: 4072 ERFSEYLQ-DEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNL 4130
Query: 271 TDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKA 330
E + L+ +A+DW+ R++Y+ D RI V +G LI +L P A
Sbjct: 4131 VQEVDLK-LKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAA 4189
Query: 331 IAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALD-LVNKLVYWVDL 389
IAV+P G +F+TD+G K+E M+G +R ++ P L++D L N +YW D
Sbjct: 4190 IAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDF 4249
Query: 390 YLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHS 449
D + + Y G +R + ++ + Y + +FED LY + + + + N+F G
Sbjct: 4250 KEDVIETIKYDGTDRRVI--AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKF-GQGKKE 4306
Query: 450 LIKIENAW--GIRIY-QKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTG 506
+ N W +RI+ Q R +V + ++ CSH+CLL + C +
Sbjct: 4307 KTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI--------CSHLCLLRPGGYSCACPQGSS 4358
Query: 507 FNLGS 511
F GS
Sbjct: 4359 FIEGS 4363
Score = 182 bits (463), Expect = 5e-45
Identities = 96/266 (36%), Positives = 131/266 (49%), Gaps = 13/266 (4%)
Query: 3308 ADNRTC-LSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCG 3365
AD C + C F+C+++ +CIP W CD DC DGSDE DC + C + C
Sbjct: 57 ADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCS 116
Query: 3366 TGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDE 3425
G C + CD DC D +DE +C C Q C N C + +C+ + DC D
Sbjct: 117 NGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTC-DNGACYNTSQKCDWKVDCRDS 173
Query: 3426 EDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKN 3485
DE +C E C + F C + CI + +VCD D DC D SDE C+ TCG ++F C +
Sbjct: 174 SDEINCTE-ICLHNEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS 231
Query: 3486 NNCIPDHWRCDSQNDCSDNSDEENCKP-----QTCTLKDFLC-ANGDCVSSRFWCDGDFD 3539
CI +W CD ++DC DN DE+ C+ C+ +++ C +G C+S CDG D
Sbjct: 232 GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
Query: 3540 CADGSDERNCETSCSKDQFRCSNGQC 3565
C DE N T CS C
Sbjct: 292 CPGREDENNTSTGKYCSMTLCSALNC 317
Score = 110 bits (275), Expect = 3e-23
Identities = 147/592 (24%), Positives = 220/592 (37%), Gaps = 106/592 (17%)
Query: 3830 KPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNF---QERNNTCIAEGSE 3886
+P + N C + N G CSH C + G + CD F Q C
Sbjct: 2334 QPRSPAEVNNNPCLENN-----GGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTEN 2388
Query: 3887 DQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGI 3946
+ ++N L + P N+S Q I+ +E D R + G I
Sbjct: 2389 FLIFALSNSLRSL-HLDPENHSPPFQTIN-VERTVMSLDYDSVSDRIYFTQNLASGVGQI 2446
Query: 3947 FYKRIHGREKRQANSGLICPE-----FKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHW 4001
Y + +SG+ P IA DW+ IY++D+
Sbjct: 2447 SYATL--------SSGIHTPTVIASGIGTADGIAFDWITRRIYYSDY------------- 2485
Query: 4002 TSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTL 4061
L IN +G N R + +P AI ++P +G +YW H+ IE A + G
Sbjct: 2486 --LNQMINSMAEDGSN--RTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 4062 RRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRI 4121
R +V +L P+GL +DY + +YW D L I G + V V++ +H +
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AVHAFGL 2598
Query: 4122 DIFEDYIYGAG-PKNGVFRVQKF-GHGSVEYLALNIDKTKGVLISHRYKQLDLPNPC--L 4177
++ YIY ++R K+ G G + + + +G+ + ++ NPC
Sbjct: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQF 2658
Query: 4178 DLACEFLCLLNPSGATCVCP-EGK-YLINGTCN---DDSLLDDSCKLTCENGGRCILNEK 4232
+ C +C P+GA C CP EG YL N + D+ + TC N GRCI E
Sbjct: 2659 NGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSN-GRCISEE- 2716
Query: 4233 GDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
W +C+ + N C +G + SV TCS FT
Sbjct: 2717 -------W------KCDND---NDCGDGSDEMESVCALHTCS-PTAFT------------ 2747
Query: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGD-DGSVECVCPTRY 4351
C N G C+ Q Y RC YY + C D + + E +C R
Sbjct: 2748 CAN-GRCV-----------QYSY---RCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRR 2792
Query: 4352 EGPKCEVDKCV-RCHGGHCIINKDSEDIFC-----NCTNGKIA-SSCQLCDG 4396
P+ + V CH + K+ D C C N I LCDG
Sbjct: 2793 CIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDG 2844
Score = 103 bits (258), Expect = 3e-21
Identities = 76/246 (30%), Positives = 102/246 (41%), Gaps = 45/246 (18%)
Query: 2800 APNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC-ADGRCL 2858
A CD F C + CIP + CD DC D +DE C C F C ++G+C+
Sbjct: 23 ASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG-CAVVTCQQGYFKCQSEGQCI 81
Query: 2859 LNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGD 2918
N+ W CD D DC D SDE + ++ +C+S C NG+CIPS CD+ DC D
Sbjct: 82 PNS-WVCDQDQDCDDGSDE-----RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPD 135
Query: 2919 GSDERNCHINEC--LSKKVSGC---------SQDCQDLPVSYKC--------------KC 2953
G+DE +C C L+ C DC+D C +C
Sbjct: 136 GADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGEC 195
Query: 2954 WPGFQLKDDGKTCVD-IDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP----DNPNGCK 3008
P + D C D DE + +P T G Y+ C G I D + CK
Sbjct: 196 IPRAYVCDHDNDCQDGSDEHACNYP-------TCGGYQFTCPSGRCIYQNWVCDGEDDCK 248
Query: 3009 SLSDEE 3014
DE+
Sbjct: 249 DNGDED 254
Score = 99.8 bits (247), Expect = 6e-20
Identities = 75/282 (26%), Positives = 104/282 (36%), Gaps = 57/282 (20%)
Query: 2486 RVNCS---CRGDRILLEDNRCVTKNSSCN-----------------AYSEFECGNGECID 2525
R +CS C +I + +C+ C+ + C NG C +
Sbjct: 100 RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
Query: 2526 YQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELD 2585
CD C+D SDE + C F C N CIP +CD +NDC D SDE
Sbjct: 160 TSQKCDWKVDCRDSSDE--INCTEICLHNEFS-CGNGECIPRAYVCDHDNDCQDGSDEHA 216
Query: 2586 CKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIR 2645
C TC +F C G CI ++ C+ DC D DE C + +K +
Sbjct: 217 CNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP-HDVHKCSPREWS--- 272
Query: 2646 CNSTSLCVLPTWICDGSNDC-----------GDYSDELKCPVQN-KHKCEENYFS----C 2689
C + C+ +CDG DC G Y C N +++C E + C
Sbjct: 273 CPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFC 332
Query: 2690 PSGRCI-------------LNTW-ICDGQKDCEDGRDEFHCD 2717
P G I W ICD + + GR HC+
Sbjct: 333 PPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCE 374
Score = 97.1 bits (240), Expect = 4e-19
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 11/159 (6%)
Query: 3307 AADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
++D C C ++F C +CIP + CD +DC DGSDE C C +F C +
Sbjct: 173 SSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE-HACNYPTCGGYQFTCPS 231
Query: 3367 GLCALPAFICDGENDCGDNSDELNC-----DTHVCLSGQFKCTKNQKCIPVNLRCNGQDD 3421
G C ++CDGE+DC DN DE C D H C ++ C ++ +CI + C+G D
Sbjct: 232 GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
Query: 3422 CGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP 3460
C ED EN+ S + T ++ + C E P
Sbjct: 292 CPGRED-----ENNTSTGKYCSMTLCSALNCQYQCHETP 325
Score = 94.0 bits (232), Expect = 3e-18
Identities = 155/642 (24%), Positives = 237/642 (36%), Gaps = 93/642 (14%)
Query: 3842 CEDLNE-CLVFGTCSHQCINVEGSYKCVCDQNFQ----ERNNTCIAEGSEDQVLYIANDT 3896
C+D N C SH+ N ++C C FQ ER+ CIA L ++
Sbjct: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERH--CIAV---QNFLIFSSQV 717
Query: 3897 DILGFIYPFNYSGDHQQISHIEHN-SRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHG-- 3953
I G PF S + + N S G+D + +D I+ + + IF ++I G
Sbjct: 718 AIRGI--PFTLSTQEDVMVPVSGNPSFFVGID-FDAQDSTIFFSDMSKHMIFKQKIDGTG 774
Query: 3954 REKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQL 4013
RE AN + +A DW++ N+YWTD S+Y SI+V +L
Sbjct: 775 REILAAN------RVENVESLAFDWISKNLYWTD-------SHYK--------SISVMRL 813
Query: 4014 NGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRP 4073
R + P ++ V+P G +++T + I A DG+ ++ L P
Sbjct: 814 -ADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWP 872
Query: 4074 TGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGP 4133
GLA+D+ + R+YW D I +DG + + + + HP + IF ++++
Sbjct: 873 NGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR-RRLGHIEQMTHPFGLAIFGEHLFFTDW 931
Query: 4134 KNG-VFRVQKFGHGSVEYLALNID-----KTKGVLI---SHRYKQLDLPNPCLDLACEFL 4184
+ G + RV+K G + + I K+ V I S+ Q PN C
Sbjct: 932 RLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNG----DCSHF 987
Query: 4185 CLLNPS-GATCVCPEGKYLING--TCNDDSLLD---DSCKL---TCENGGRCILNEKGDL 4235
C P+ C CP G L + TC D + + C L C+N GRC+ N
Sbjct: 988 CFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKN-GRCVPN----- 1041
Query: 4236 RCHCWPSYSGERCEVNHCSNYCQN-GGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQ 4294
+ + C N C TC S +C G P + + C
Sbjct: 1042 ---YYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-----TCGHGECIPAHWRCDKRNDCV 1093
Query: 4295 NGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDD----GSVECVCPTR 4350
+G + P +YT D Q + C C G D S E P++
Sbjct: 1094 DGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ 1153
Query: 4351 YEGP--KCEVDKCVRCHGG-HCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLD 4407
+ P +C +D C G C+ D NCT + C +G C
Sbjct: 1154 FNCPNHRC-IDLSFVCDGDKDCVDGSDEVGCVLNCTASQFK---------CASGDKCIGV 1203
Query: 4408 PETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVP 4449
V CS N C P SD + I +P
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIP 1245
Score = 90.9 bits (224), Expect = 3e-17
Identities = 53/142 (37%), Positives = 69/142 (48%), Gaps = 12/142 (8%)
Query: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRW 903
IC EF C N CI + CD D+DC DGSDE + C +C QF C + RCI + W
Sbjct: 182 ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA--CNYPTCGGYQFTCPSGRCIYQNW 239
Query: 904 LCDGANDCGSNEDE---SNQTCTARTCQVDQFSC-GNGRCIPRAWLCDREDDCGDQTDEM 959
+CDG +DC N DE + C ++SC +GRCI +CD DC + DE
Sbjct: 240 VCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDEN 299
Query: 960 AS-----CEFPTCEPLT-QFVC 975
+ C C L Q+ C
Sbjct: 300 NTSTGKYCSMTLCSALNCQYQC 321
Score = 86.3 bits (212), Expect = 7e-16
Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 33/220 (15%)
Query: 3671 GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICL 3730
G C + F C + C W CDG DC D++DE C C +C++ C+
Sbjct: 25 GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGY-FKCQSEGQCI 81
Query: 3731 QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDG 3790
+ +C+ +C D SDE + T C + CSN +CIP + +CD + DC DG
Sbjct: 82 PNSWVCDQDQDCDDGSDERQDCSQST-----CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
Query: 3791 SDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLV 3850
+DE C+ TCE C + A N TS C K C D ++ +
Sbjct: 137 ADENDCQYP----TCEQLT--CDNGACYN---TSQKCDWKV---------DCRDSSDEI- 177
Query: 3851 FGTCSHQCINVE---GSYKCVCDQNFQERNNTCIAEGSED 3887
C+ C++ E G+ +C+ + +N C +GS++
Sbjct: 178 --NCTEICLHNEFSCGNGECIPRAYVCDHDNDC-QDGSDE 214
Score = 71.6 bits (174), Expect = 2e-11
Identities = 52/152 (34%), Positives = 69/152 (45%), Gaps = 22/152 (14%)
Query: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
+C +FLC ++ C+ W CDG DC D SDE L CP+ C L C N C
Sbjct: 3511 MCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQRF---CRLGQFQCSDGN-C 3565
Query: 91 VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDGFEIT 147
LCN +CPDG DE LL C+ +C +++C R + D F
Sbjct: 3566 TSPQTLCNAHQNCPDGSDE----DRLL--CENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
Query: 148 EDGRSCKDQDECAVYGTCSQTCRNTHGSYTCS 179
ED S +D CA S+TCR G + C+
Sbjct: 3620 ED-NSDEDSSHCA-----SRTCR--PGQFRCA 3643
Score = 70.9 bits (172), Expect = 3e-11
Identities = 47/151 (31%), Positives = 64/151 (42%), Gaps = 31/151 (20%)
Query: 30 QLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNK 89
Q CD F C C+ W CDG DC DD+DE C + C + C +
Sbjct: 26 QECDSAHFRCGSG-HCIPADWRCDGTKDCSDDADEI--GC---AVVTCQQGYFKCQSEGQ 79
Query: 90 CVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC--------QYKCTMVRNSTRCYCE 141
C+ S +C+ DC DG DE C + + Q+ C +Y+C VR+ C
Sbjct: 80 CIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRD-----CP 134
Query: 142 DGFEITEDGRSCKDQDECAVYGTCSQ-TCRN 171
DG D+++C Y TC Q TC N
Sbjct: 135 DG----------ADENDCQ-YPTCEQLTCDN 154
Score = 70.1 bits (170), Expect = 5e-11
Identities = 50/163 (30%), Positives = 67/163 (41%), Gaps = 27/163 (16%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C G F C C+ SW+CD D DC D SDE D C + C + I C +C+
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQST---CSSHQITC-SNGQCI 121
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
C+ V DCPDG DE CQ C+QL C S +C + D R
Sbjct: 122 PSEYRCDHVRDCPDGADEN-DCQ--YPTCEQLTCD-NGACYNTSQKC------DWKVDCR 171
Query: 152 SCKDQDECAVYGTCSQTCRNTHGSYTC---SCV-EGYLMQPDN 190
D+ C++ C H ++C C+ Y+ DN
Sbjct: 172 DSSDEI------NCTEIC--LHNEFSCGNGECIPRAYVCDHDN 206
Score = 41.6 bits (96), Expect = 0.018
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 4398 CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLI 4457
C +GG C D ET++P C C + ++G CE SK T ++A+++ ++L+V +
Sbjct: 4383 CMHGGNCYFD-ETDLPKCKCPSGYTGKYCEM---AFSKGISPGTTAVAVLLTILLIVVIG 4438
Query: 4458 TTLVIGLVLCKR 4469
+ G +R
Sbjct: 4439 ALAIAGFFHYRR 4450
Score = 35.8 bits (81), Expect = 1.0
Identities = 43/170 (25%), Positives = 58/170 (34%), Gaps = 37/170 (21%)
Query: 4239 CWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGT 4298
C SG+ C+ H + G C+P+ C G C D G
Sbjct: 19 CLAPASGQECDSAH---FRCGSGHCIPADW---RCD----------GTKDCSDDADEIGC 62
Query: 4299 CIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEV 4358
+VT Q Y CQ E Q C + C G D +C T C
Sbjct: 63 AVVTC-QQGYFKCQSEG-----QCIPNSWVCDQDQDCDDGSDERQDCSQST------CSS 110
Query: 4359 DKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ-------LCD-GYCYN 4400
+ + C G CI ++ D +C +G + CQ CD G CYN
Sbjct: 111 HQ-ITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 1080 bits (2793), Expect = 0.0
Identities = 609/1668 (36%), Positives = 923/1668 (55%), Gaps = 105/1668 (6%)
Query: 857 CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNED 916
CI A+W+CDGD+DC D SDED C +C F C N +CI + W+CDG NDC + D
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDG--CILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSD 101
Query: 917 ESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCK 976
E Q C R C+ D+F C NG CI W CD ++DCGD +DE C+ C +F C
Sbjct: 102 E--QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ--CDMRKCSD-KEFRCS 156
Query: 977 SGRCISSKWHCDSDDDCGDGSDEVGCVHS-----CFDNQFRCSSGRCIPGHWACDGDNDC 1031
G CI+ W+CD D DC DGSDE C + C +F+C+ GRCI + CDGD+DC
Sbjct: 157 DGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDC 216
Query: 1032 GDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGT 1091
GD+SDE+ +C+ H P C EF C G C+ WRCDG+ DC+D SDE+ C T
Sbjct: 217 GDWSDES--DCSS---HQP--CRSGEFMCD-SGLCINAGWRCDGDADCDDQSDERNC--T 266
Query: 1092 IRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVC- 1150
+C + +F C S GRC+ +W CDG+ DC D SDE++C++ G P+ CA D +C
Sbjct: 267 TSMCTAE-QFRCHS-GRCVRLSWRCDGEDDCADNSDEENCEN--TGSPQ--CALDQFLCW 320
Query: 1151 ----LQPEKLCNGKKDCPDGSDEG--YLC------DECSLNNGGCSNHCSVVPGRGIVCS 1198
+ KLCNG DC D SDE C + C++NNGGC+ C +V G + C+
Sbjct: 321 NGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRG-AVQCT 379
Query: 1199 CPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPF 1258
C G +L +D TC+ V+ C+ CSQ C + +C C G++L D SC ++ P
Sbjct: 380 CHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGP- 438
Query: 1259 EAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLS 1318
E ++F+ R +IR++ H+ +Y+LL+ L N IALDFH + L++W+DV DRI R L+
Sbjct: 439 EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLN 498
Query: 1319 ESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAME 1378
S +E VV GL +P GL VDW+ +YW DS +IEVA LDG+ R L+ +E
Sbjct: 499 GSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLE 554
Query: 1379 HPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKR 1438
PRAIAL P G ++WTDW N PRIE++SM G+GR+ I WPNGLT+D+ +R
Sbjct: 555 KPRAIALHPMEGTIYWTDW-GNTPRIEASSMDGSGRRIIADTHL--FWPNGLTIDYAGRR 611
Query: 1439 IVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKW 1498
+ W DA+ I A DG++ +I + L HPFA++++ +YWTDW T +++ ANK+
Sbjct: 612 MYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 669
Query: 1499 TGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPH 1558
TG+N +I+ P D+ HP RQP N C D G C+H+CL + ++ CACP
Sbjct: 670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC--GDNNGGCTHLCLPS-GQNYTCACPT 726
Query: 1559 LMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEE 1618
+ S + KFLL+ARR +IR + D + + D+ +D+D+ ++
Sbjct: 727 GFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLS-DDVIPLADVRSAVALDWDSRDD 785
Query: 1619 RLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVA 1678
+YWTD+ T TI RA +GTG E V+ ++S GLA+DWV+ LYW + D +I VA
Sbjct: 786 HVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTD--RIEVA 843
Query: 1679 RLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTDGNT---INMANMDGSNSKILF-QNQK 1733
DGS++T +I +D+P+ + P+ G +YWTD I A MD S +++ N
Sbjct: 844 NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903
Query: 1734 EPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWA 1793
P GL+IDY +LYW +G TI LDG +V+ + +L LT+ ++++W
Sbjct: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVL--IGSQLPHPFGLTLYGERIYWT 961
Query: 1794 DQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTS 1853
D + + + G + L+ ++ + V+ + S C + NGGCS LCL +
Sbjct: 962 DWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSP 1021
Query: 1854 ETTR-TCMCTVGYYLQKNRMSCQ-GIESFLMYSVHEGIRGIPLEPSDKMDALMPISGT-- 1909
+ +C C G L + +C G+ SFL+++ IR + L+ D ++PI+ T
Sbjct: 1022 NPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMK 1081
Query: 1910 -SFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIY 1968
+ A+G+D + +YW+D ++ISRA D + EDIIT GL +G+AVD I +Y
Sbjct: 1082 NTIAIGVD--PQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVY 1139
Query: 1969 WTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDG 2028
WTD G N IEV L+GS R V++ Q LD PR+I ++ E G ++WT+WG+ + ++ +DG
Sbjct: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
Query: 2029 SEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFS 2088
S++ VL++ + WPNG+++D ++L W DA T++IE DL G NR ++S +
Sbjct: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADL-NGANRHTLVSPVQ-HPYG 1257
Query: 2089 VAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCA 2148
+ + +YIYW+D S+ R K + I +R+ L L +++ +R + G N C
Sbjct: 1258 LTLLDSYIYWTD--WQTRSIHRADKGTGSNVILVRSNL-PGLMDMQAVDRAQPLGFNKCG 1314
Query: 2149 RDNGGCKQLCLYRGNSRRTCACAHG-YLAEDGVTC-LRHEGYLLYSGRTILKSIHL--SD 2204
NGGC LCL R S +CAC G L DG TC E YLL+S R ++ I L SD
Sbjct: 1315 SRNGGCSHLCLPR-PSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSD 1373
Query: 2205 ETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVI 2264
T+++ P+ NVI+L +D +++Y+D I+ N + + +
Sbjct: 1374 HTDVHVPVPE------LNNVISLDYD-----SVDGKVYYTDVFLDVIRRADLNGSNMETV 1422
Query: 2265 V-ENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVL 2323
+ + + +GLA LYWT + R+T++ +R R+ +I S D+ P +
Sbjct: 1423 IGRGLKTTDGLAVDWVARNLYWTDT-----GRNTIEASRLDGSCRKVLINNSLDE-PRAI 1476
Query: 2324 ALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGS 2383
A+ + +FWT+W I R+ L G +V+++TD+ PNGLT+DY ++Y+ D
Sbjct: 1477 AVFPRKGYLFWTDWG-HIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAH 1535
Query: 2384 LGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILR 2443
L +IE + +G R V+V F +L D +I+W+DW ++I R +KY+G + + +
Sbjct: 1536 LDRIESADLNGKLRQVLVSHVSHPF-ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVL 1594
Query: 2444 SDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 2491
+++ + + I V + + C + NGGC LC + V C+C
Sbjct: 1595 ANV--EGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFV-CAC 1639
Score = 547 bits (1410), Expect = e-155
Identities = 296/738 (40%), Positives = 406/738 (55%), Gaps = 60/738 (8%)
Query: 2591 CATVEFRCA-----DGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIR 2645
C F CA + TCIP +C+ + DC D SDE C C+
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLD---------FH 77
Query: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQK 2705
C++ C+ +W+CDG NDC D SDE CP + +CEE+ F C +G CI + W CDG
Sbjct: 78 CDNGK-CIRRSWVCDGDNDCEDDSDEQDCPPR---ECEEDEFPCQNGYCIRSLWHCDGDN 133
Query: 2706 DCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD--SICGAITCA 2762
DC D DE CD CS +F CS CI++HW CDG+ DC DG DE + S A C
Sbjct: 134 DCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCN 192
Query: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
+ F C R C+ + CDG+ DC D SDE + C+ + C FMC + +CI +
Sbjct: 193 LEEFQCAYGR-CILDIYHCDGDDDCGDWSDE---SDCSSHQPCRSGEFMCDSGLCINAGW 248
Query: 2823 VCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNP 2882
CD D DC D SDE C C E+F C GRC+ W+CDG+ DC D+SDE
Sbjct: 249 RCDGDADCDDQSDER-NCTTSMCTAEQFRCHSGRCV-RLSWRCDGEDDCADNSDEENCE- 305
Query: 2883 KCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE------------RNCHINEC 2930
+ C F+C NGRCI LC+ +DCGD SDE NC++N
Sbjct: 306 --NTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN- 362
Query: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
GC+Q CQ + + +C C G++L +DG TC D++EC+ CSQ C N+ G ++
Sbjct: 363 -----GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQ 417
Query: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
C C GYE++PD CK+L E P L+ A+ +IR++ S YTLL L N IA+DF
Sbjct: 418 CWCETGYELRPDR-RSCKALGPE-PVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDF 475
Query: 3051 DYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEK 3108
+R E ++W D + RI R LNGS+++ V +T + P LAVDW+ LYW+D+
Sbjct: 476 HHRRELVFWSDVTL---DRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532
Query: 3109 RIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVV 3168
IEV+ L+G + +L+ + L+ PR ++L P G +YW D P I MDG+ + ++
Sbjct: 533 SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592
Query: 3169 IETKISRPMALTIDYVNRRLYWADENH--IEFSNMDGSHRHKVPNQDIPGVIALTLFEDY 3226
+T + P LTIDY RR+YW D H IE +N+DGSHR V +Q +P A+T+FED
Sbjct: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDS 652
Query: 3227 IYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSH 3286
+YWTD TKS++ A+K +G ++ + H DI H RQP K+ C NNGGC+H
Sbjct: 653 LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQP-AGKNRCGDNNGGCTH 711
Query: 3287 LCLLAPGKTHTCACPTNF 3304
LC L G+ +TCACPT F
Sbjct: 712 LC-LPSGQNYTCACPTGF 728
Score = 446 bits (1148), Expect = e-124
Identities = 267/783 (34%), Positives = 370/783 (47%), Gaps = 93/783 (11%)
Query: 3432 PENSCSPDYFQCKTTK----HCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN 3487
PE +C +F C + CI W CD D DC D SDE C TC P +F C N
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK 82
Query: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDER 3547
CI W CD NDC D+SDE++C P+ C +F C NG C+ S + CDGD DC D SDE+
Sbjct: 83 CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Query: 3548 NCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPA--SPTCSSREYICASDG 3605
CS +FRCS+G CI W CDG DCK G DE++C A +P C+ E+ CA
Sbjct: 143 CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGR 202
Query: 3606 CISASLKCNGEYDCADGSDEMDCVTE--CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSD 3663
CI C+G+ DC D SDE DC + C+ +F C + CI W CDG DC D SD
Sbjct: 203 CILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC-DSGLCINAGWRCDGDADCDDQSD 261
Query: 3664 EENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHR- 3722
E NC ++C A++F C++ C W CDGEDDC DNSDE + C P +
Sbjct: 262 ERNCTT--SMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDE--ENCENTGSPQCALDQF 317
Query: 3723 -CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQC 3781
C N R C+ ++CNG+++CGDNSDE
Sbjct: 318 LCWNGR-CIGQRKLCNGVNDCGDNSDE--------------------------------- 343
Query: 3782 DRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQ 3841
S +Q CR E C NVN G C ++ +V C C G++
Sbjct: 344 ---------SPQQNCRPRTGEENC--NVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHT 392
Query: 3842 CEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDIL 3899
C+D+NEC G CS C N EG+++C C+ ++ R +C A G E VL AN DI
Sbjct: 393 CQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPE-PVLLFANRIDIR 451
Query: 3900 GFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQA 3959
+ + ++ + + N+ +D +++R+++ WS I ++G +
Sbjct: 452 QVL---PHRSEYTLLLNNLENA--IALDFHHRRELVFWS-DVTLDRILRANLNGSNVEE- 504
Query: 3960 NSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCT 4019
++ + P +AVDWV +YWTD I V L+G +
Sbjct: 505 ---VVSTGLESPGGLAVDWVHDKLYWTDSGTSR---------------IEVANLDGAHRK 546
Query: 4020 RLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVD 4079
LL +P AIA++P G +YWT G+ IE ++MDG+ RRI+ +L P GL +D
Sbjct: 547 VLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTID 606
Query: 4080 YFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVF 4138
Y R+YW D + +I DGS+ +S QGL HP I +FED +Y +
Sbjct: 607 YAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPHPFAITVFEDSLYWTDWHTKSIN 664
Query: 4139 RVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGATCVC 4196
KF + E + + + H +Q N C D C LCL + TC C
Sbjct: 665 SANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCAC 724
Query: 4197 PEG 4199
P G
Sbjct: 725 PTG 727
Score = 443 bits (1140), Expect = e-123
Identities = 273/814 (33%), Positives = 416/814 (51%), Gaps = 48/814 (5%)
Query: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
+C +F CH CV SW CDG+ DC D+SDE + C +C L+ C +C
Sbjct: 269 MCTAEQFRCHSG-RCVRLSWRCDGEDDCADNSDE--ENCENTGSPQCALDQFLCWN-GRC 324
Query: 91 VHLSQLCNGVLDCPDGYDEGV--HCQELLS--NCQQLN--CQYKCTMVRNSTRCYCEDGF 144
+ +LCNGV DC D DE +C+ NC N C KC MVR + +C C G+
Sbjct: 325 IGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGY 384
Query: 145 EITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
+TEDG +C+D +ECA G CSQ C N+ G++ C C GY ++PD RSCKA P
Sbjct: 385 RLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKA----LGPEP 440
Query: 205 ILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQI 264
+LL AN I + S+ L + N I LDF + +++ W S L I
Sbjct: 441 VLLFANRIDIRQVLPHRSEYTLLLNNLENAI-ALDFHHRRELVFW-----SDVTLDRILR 494
Query: 265 TKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE 324
G E ++ + +A+DW+ LY+ D RI V N +G+ L+
Sbjct: 495 ANLNGSNVEEVVS--TGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQN 552
Query: 325 LHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLV 384
L P+AIA+ P+ G +++TD+GN ++E MDG R I D+ P L +D + +
Sbjct: 553 LEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRM 612
Query: 385 YWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNG 444
YWVD + + G +R VI + + H + ITVFED LY T+ +I N+F G
Sbjct: 613 YWVDAKHHVIERANLDGSHRKAVI-SQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG 671
Query: 445 TDIHSL-IKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
+ + K+ I + QP ++ + + GGC+H+CL S + TC C
Sbjct: 672 KNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNN-----GGCTHLCLPSG--QNYTCAC 724
Query: 504 RTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDF 563
TGF S +C + ++ LF R +R + +T+ + +IP+ ++ + ALD+
Sbjct: 725 PTGFRKIS-SHACAQSLDKFLLF---ARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW 780
Query: 564 HAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKT 623
+ +++Y+ D ++ I R K DGT +E ++ L++ G+A+DW+ N LYWT+ G +
Sbjct: 781 DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDR- 839
Query: 624 INVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDG 683
I VA + R L+ + PR IVV+P+ G+MYWTDW + +IE+A MD
Sbjct: 840 IEVANTD--GSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW------GASPKIERAGMDA 891
Query: 684 FNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFG 743
RQ+ ++S + WPNGL +D+ + LYW DA IE L+G+ RK++ G +L HPFG
Sbjct: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI-GSQLPHPFG 950
Query: 744 LSHHGNYVFWTDYMNGSIFQLDLITS-EVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNN 802
L+ +G ++WTD+ SI D +T + L+ L + ++ R+ C + N
Sbjct: 951 LTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMEN 1010
Query: 803 GGCSTLCLAI--PGGRVCACADNQLLDENGTTCT 834
GGCS LCL P G C C L +G TC+
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCS 1044
Score = 337 bits (863), Expect = 2e-91
Identities = 215/680 (31%), Positives = 338/680 (49%), Gaps = 39/680 (5%)
Query: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
G C+ C + +YTC+C G+ + + +C ++ LL A I +
Sbjct: 707 GGCTHLCLPSGQNYTCACPTGF-RKISSHACAQSLDK-----FLLFARRMDIRRISFDTE 760
Query: 223 KMA--TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQ 280
++ + + LD+ +D + W + + I K G E ++
Sbjct: 761 DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDT-----ISRAKWDGTGQEVVVDT-- 813
Query: 281 SFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKL 340
S + +AIDW+T LY+ D DRI V N++GS+ LI L P+ I V+P+ G +
Sbjct: 814 SLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYM 873
Query: 341 FFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQ 400
++TD+G K+ER MD R II S P LA+D ++ +YW D + +
Sbjct: 874 YWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLD 933
Query: 401 GKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGI 459
G R +I G Q+ H +G+T++ + +Y T+ +I +R G D +L + +EN I
Sbjct: 934 GSKRKVLI-GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDI 992
Query: 460 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP 519
++ +R P A E GGCSH+CL S + +C C TG NL SDG++C
Sbjct: 993 HVFHRRRPPVSTPCAME------NGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPG 1046
Query: 520 KNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIE-NLVNPRALDFHAETNYIYFADTTSF 578
N +F R +R + L+ + ++PI + N A+ + +Y++D+T
Sbjct: 1047 MNSFLIF---ARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLH 1103
Query: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
I R +DG++ E I+ L +G+AVD IG +YWT+ G + I V L+ RK
Sbjct: 1104 RISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNR-IEVGNLD--GSMRKV 1160
Query: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698
L+ + PR IV+ G+MYWTDW E+ ++E++ MDG +R + + + + WPN
Sbjct: 1161 LVWQNLDSPRAIVLYHEMGFMYWTDWGEN------AKLERSGMDGSDRAVLINNNLGWPN 1214
Query: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758
GLT+D ++ L W DA+ + IE LNG +R + S + HP+GL+ +Y++WTD+
Sbjct: 1215 GLTVDKASSQLLWADAHTERIEAADLNGANRHTLVS--PVQHPYGLTLLDSYIYWTDWQT 1272
Query: 759 GSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRV 817
SI + D T S V L+R P L +Q D + G N C NGGCS LCL P G
Sbjct: 1273 RSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFS 1332
Query: 818 CACADNQLLDENGTTCTFNP 837
CAC L +G TC +P
Sbjct: 1333 CACPTGIQLKGDGKTCDPSP 1352
Score = 336 bits (862), Expect = 3e-91
Identities = 216/716 (30%), Positives = 366/716 (51%), Gaps = 38/716 (5%)
Query: 1828 DKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQ--GIESFLMYSV 1885
D Q N C G CSQ C SE C C GY L+ +R SC+ G E L+++
Sbjct: 389 DGHTCQDVNECA-EEGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFAN 446
Query: 1886 HEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKE 1945
IR + S+ + ++ A+ +DFH + ++W+D+ ++I RA + + E
Sbjct: 447 RIDIRQVLPHRSEYT---LLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVE 503
Query: 1946 DIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHP 2005
++++ GL G+AVDW+ +YWTD G + IEVA L+G+ R V++ Q L++PR+IA+HP
Sbjct: 504 EVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHP 563
Query: 2006 EKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIE 2065
+G ++WT+WG P I + +DGS + ++ + WPNG++IDY ++YW DA+ IE
Sbjct: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623
Query: 2066 RIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTG 2125
R +L+ G +R+ V+S F++ VF +YW+D S+ +K +R
Sbjct: 624 RANLD-GSHRKAVISQGLPHPFAITVFEDSLYWTD--WHTKSINSANKFTGKNQEIIRNK 680
Query: 2126 LGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRH 2185
L + + + + G N C +NGGC LCL G + TCAC G+ C +
Sbjct: 681 LHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN-YTCACPTGFRKISSHACAQS 739
Query: 2186 -EGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYS 2244
+ +LL++ R ++ I D +L+ + P + R A+A D++ R + ++++
Sbjct: 740 LDKFLLFARRMDIRRISF-DTEDLSDDVIPLADVR-----SAVALDWDSR---DDHVYWT 790
Query: 2245 DAHFGNIQLIKDNWEDRQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRP 2303
D I K + ++V+V+ ++ S GLA + LYWT + T I D +
Sbjct: 791 DVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGS-- 848
Query: 2304 GAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDIL 2363
V+ D P + ++ M+WT+W P I R+ + QV++S+++
Sbjct: 849 ----MRTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLT 903
Query: 2364 TPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDW 2423
PNGL IDY +++LY++D + IE DGS+R V++ S L +Y I+W+DW
Sbjct: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963
Query: 2424 GRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTP 2483
++I +++ TG D + L+ ++ + + I V + +PCA+ NGGC LCL +P
Sbjct: 964 QTKSIQSADRLTGLDRETLQENL--ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSP 1021
Query: 2484 N-GRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKD 2538
N +C+C LL D + T + N++ F ID ++ IP+ D
Sbjct: 1022 NPSGFSCTCPTGINLLSDGK--TCSPGMNSFLIF----ARRIDIRMVSLDIPYFAD 1071
Score = 321 bits (823), Expect = 9e-87
Identities = 209/690 (30%), Positives = 339/690 (49%), Gaps = 53/690 (7%)
Query: 163 GTCSQTCRNTHG--SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220
G CS C + ++C+C G + D ++C + L+ A I + L+
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNS-----FLIFARRIDIRMVSLD 1065
Query: 221 GSKMATLS---SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTIN 277
A + ++ + E + W S + L I G E I
Sbjct: 1066 IPYFADVVVPINITMKNTIAIGVDPQEGKVYW-----SDSTLHRISRANLDGSQHEDIIT 1120
Query: 278 ILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIA 337
+A+D + R +Y+ D +RI V N +GS+ L+ L +P+AI +
Sbjct: 1121 T--GLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM 1178
Query: 338 GKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 397
G +++TD+G AK+ER MDG +R +I++ P L +D + + W D + + +
Sbjct: 1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
Query: 398 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW 457
D G NRHT++ V+H YG+T+ + Y+Y T+ +I R ++ G+++ ++ N
Sbjct: 1239 DLNGANRHTLVS--PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV--ILVRSNLP 1294
Query: 458 GIRIYQ--KRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRS 515
G+ Q R QP + + C GGCSH+CL S +C C TG L DG++
Sbjct: 1295 GLMDMQAVDRAQP-LGFNKCG----SRNGGCSHLCLPRPS--GFSCACPTGIQLKGDGKT 1347
Query: 516 CKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADT 575
C P E +L + G +R + L+T + +P+ L N +LD+ + +Y+ D
Sbjct: 1348 CD-PSPETYLLFSS--RGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDV 1404
Query: 576 TSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQS 635
+I R ++G+ ET++ L +G+AVDW+ NLYWT+ G R TI +RL+
Sbjct: 1405 FLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG-RNTIEASRLD--GSC 1461
Query: 636 RKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKML 695
RK L+ + PR I V P G+++WTDW + +IE+A +DG R++ + + +
Sbjct: 1462 RKVLINNSLDEPRAIAVFPRKGYLFWTDW------GHIAKIERANLDGSERKVLINTDLG 1515
Query: 696 WPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTD 755
WPNGLTLD+ T +YW DA+ D IE LNG R+++ S ++HPF L+ +++WTD
Sbjct: 1516 WPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQDRWIYWTD 1573
Query: 756 YMNGSIFQLDLIT---SEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAI 812
+ SI ++D + E L E L + + P++Q G N C VNNGGC+ LC A
Sbjct: 1574 WQTKSIQRVDKYSGRNKETVLANVE--GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFAR 1631
Query: 813 PGGRVCACADNQLLDENGTTCTFNPGEALP 842
VCAC D + + C+ PG P
Sbjct: 1632 ASDFVCACPD----EPDSRPCSLVPGLVPP 1657
Score = 286 bits (733), Expect = 3e-76
Identities = 144/346 (41%), Positives = 189/346 (54%), Gaps = 23/346 (6%)
Query: 3287 LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGS 3346
LC + CAC + + A + L CT CIP W+CD +DCGD S
Sbjct: 14 LCAHGLASSPECACGRSHFTCAVS--ALGECT----------CIPAQWQCDGDNDCGDHS 61
Query: 3347 DEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKN 3406
DE D C C P F C G C +++CDG+NDC D+SDE +C C +F C +N
Sbjct: 62 DE-DGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QN 119
Query: 3407 QKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS 3466
CI C+G +DCGD DE+ C CS F+C + CI++ W CD D DC D S
Sbjct: 120 GYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRC-SDGSCIAEHWYCDGDTDCKDGS 177
Query: 3467 DEANCDKKT----CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP-QTCTLKDFL 3521
DE NC C EFQC CI D + CD +DC D SDE +C Q C +F+
Sbjct: 178 DEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFM 237
Query: 3522 CANGDCVSSRFWCDGDFDCADGSDERNCETS-CSKDQFRCSNGQCIPAKWKCDGHEDCKY 3580
C +G C+++ + CDGD DC D SDERNC TS C+ +QFRC +G+C+ W+CDG +DC
Sbjct: 238 CDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCAD 297
Query: 3581 GEDEKSCE-PASPTCSSREYICASDGCISASLKCNGEYDCADGSDE 3625
DE++CE SP C+ +++C + CI CNG DC D SDE
Sbjct: 298 NSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Score = 224 bits (571), Expect = 2e-57
Identities = 126/344 (36%), Positives = 195/344 (56%), Gaps = 17/344 (4%)
Query: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDG---SN 3034
C+ C+ + Y C C G+ + + + C D+ FL+ A +IR+IS D S+
Sbjct: 709 CTHLCLPSGQNYTCACPTGF--RKISSHACAQSLDK--FLLFARRMDIRRISFDTEDLSD 764
Query: 3035 YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 3092
+ + + +A+D+D R++ +YW D S I+R +G+ +VV +T++ P L
Sbjct: 765 DVIPLADVRSAVALDWDSRDDHVYWTDVSTDT---ISRAKWDGTGQEVVVDTSLESPAGL 821
Query: 3093 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEY 3152
A+DW+ LYW+D IEV+ +G T+L+ + L PRD+ ++P GY+YW D
Sbjct: 822 AIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS 881
Query: 3153 PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKVP 3210
P I R GMD + + V+I + ++ P L IDY ++RLYWAD IEF+ +DGS R +
Sbjct: 882 PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI 941
Query: 3211 NQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQP 3270
+P LTL+ + IYWTD +TKS+ A + +G DR +L + + DI V+H R+P
Sbjct: 942 GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR-RRP 1000
Query: 3271 DVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAADNRTC 3313
VS C + NGGCSHLCL +P + +C CPT L +D +TC
Sbjct: 1001 PVSTP-CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
Score = 199 bits (506), Expect = 5e-50
Identities = 130/393 (33%), Positives = 195/393 (49%), Gaps = 62/393 (15%)
Query: 2928 NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG 2987
N+C S+ GCS C P + C C G QLK DGKTC
Sbjct: 1311 NKCGSRN-GGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--------------------- 1348
Query: 2988 TYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYT---LLKQGLNN 3044
+P+ E +L+ + IR+IS D S++T + LNN
Sbjct: 1349 ---------------DPS-------PETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
Query: 3045 VIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLY 3102
VI++D+D + +Y+ D I R LNGS+++ V + LAVDW+ +NLY
Sbjct: 1387 VISLDYDSVDGKVYYTDVFL---DVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLY 1443
Query: 3103 WSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDG 3162
W+DT + IE S+L+G +L++ L PR +++ P+ GYL+W D I R +DG
Sbjct: 1444 WTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDG 1503
Query: 3163 TNQSVVIETKISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIAL 3220
+ + V+I T + P LT+DY RR+YW D + IE ++++G R +V + AL
Sbjct: 1504 SERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLR-QVLVSHVSHPFAL 1562
Query: 3221 TLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMIN 3280
T + +IYWTD +TKS+ R K SG ++ +++ + + DI V RQ + C +N
Sbjct: 1563 TQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVN 1620
Query: 3281 NGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
NGGC+HLC A CACP D+R C
Sbjct: 1621 NGGCTHLC-FARASDFVCACPDE----PDSRPC 1648
Score = 184 bits (466), Expect = 2e-45
Identities = 117/346 (33%), Positives = 183/346 (52%), Gaps = 20/346 (5%)
Query: 2978 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035
CS C+ + + C C G + D ++ FLI A +IR +S D +
Sbjct: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNS---FLIFARRIDIRMVSLDIPYF 1069
Query: 3036 TLLKQGLN----NVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVP-- 3089
+ +N N IAI D +E +YW DS+ RI+R L+GS + + T +
Sbjct: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTL---HRISRANLDGSQHEDIITTGLQTT 1126
Query: 3090 NALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDC 3149
+ LAVD IG+ +YW+DT IEV L+G +LV + L PR + L + G++YW D
Sbjct: 1127 DGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186
Query: 3150 CEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRH 3207
E + R GMDG++++V+I + P LT+D + +L WAD + IE ++++G++RH
Sbjct: 1187 GENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRH 1246
Query: 3208 KVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSY 3267
+ + + LTL + YIYWTD +T+S+ RA K +G++ + + + + D+Q
Sbjct: 1247 TLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVD-- 1303
Query: 3268 RQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
R + + C NGGCSHLCL P +CACPT L D +TC
Sbjct: 1304 RAQPLGFNKCGSRNGGCSHLCLPRP-SGFSCACPTGIQLKGDGKTC 1348
Score = 143 bits (361), Expect = 3e-33
Identities = 84/251 (33%), Positives = 123/251 (49%), Gaps = 24/251 (9%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC 3376
C +F+C +CI + CD DDCGD SDE D C+ G F C +GLC + C
Sbjct: 191 CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRC 250
Query: 3377 DGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
DG+ DC D SDE NC T +C + QF+C + +C+ ++ RC+G+DDC D DE +C EN+
Sbjct: 251 DGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWRCDGEDDCADNSDEENC-ENTG 308
Query: 3437 SP----DYFQCKTTKHCISKLWVCDEDPDCADASDEA---NCDKKTCGPHEFQCKNNNC- 3488
SP D F C + CI + +C+ DC D SDE+ NC +T G N C
Sbjct: 309 SPQCALDQFLCWNGR-CIGQRKLCNGVNDCGDNSDESPQQNCRPRT-GEENCNVNNGGCA 366
Query: 3489 -----IPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSS----RFWCDGDFD 3539
+ +C D C+ ++ C+ G C +S + WC+ ++
Sbjct: 367 QKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG-CTNSEGAFQCWCETGYE 425
Query: 3540 CADGSDERNCE 3550
D R+C+
Sbjct: 426 LR--PDRRSCK 434
Score = 125 bits (314), Expect = 1e-27
Identities = 105/378 (27%), Positives = 160/378 (42%), Gaps = 39/378 (10%)
Query: 3838 KNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTD 3897
KNR C D N G C+H C+ +Y C C F++ ++ A+ S D+ L A D
Sbjct: 699 KNR-CGDNN-----GGCTHLCLPSGQNYTCACPTGFRKISSHACAQ-SLDKFLLFARRMD 751
Query: 3898 ILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKR 3957
I + D + + +D + D + W T + I + G +
Sbjct: 752 IRRISFDTEDLSD--DVIPLADVRSAVALDWDSRDDHVYW-TDVSTDTISRAKWDGTGQE 808
Query: 3958 QANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPN 4017
++ + P +A+DWV +YWTD I V +G
Sbjct: 809 V----VVDTSLESPAGLAIDWVTNKLYWTDAGTDR---------------IEVANTDGSM 849
Query: 4018 CTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLA 4077
T L+ P I V P G MYWT G IE A MD + R++++ NL P GLA
Sbjct: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLA 909
Query: 4078 VDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNG 4136
+DY S+R+YWAD + I DGS V + S+ L HP + ++ + IY
Sbjct: 910 IDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKS 967
Query: 4137 VFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLL--NPSGA 4192
+ + E L N++ + + HR ++ + PC + C LCL NPSG
Sbjct: 968 IQSADRLTGLDRETLQENLENLMDIHVFHR-RRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
Query: 4193 TCVCPEGKYLING--TCN 4208
+C CP G L++ TC+
Sbjct: 1027 SCTCPTGINLLSDGKTCS 1044
Score = 122 bits (307), Expect = 6e-27
Identities = 90/287 (31%), Positives = 119/287 (41%), Gaps = 37/287 (12%)
Query: 2458 NDTNSCELSPCALLNGGCHDLCLLTPN----GRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
N C++ C+ C D + + G +C D E+ CN
Sbjct: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE---ENCPSAVPAPPCNL- 193
Query: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDG 2573
EF+C G CI CDG C D SDE ++ CR G C + CI G CDG
Sbjct: 194 EEFQCAYGRCILDIYHCDGDDDCGDWSDESDC-SSHQPCRSGEFMCDSGLCINAGWRCDG 252
Query: 2574 ENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHF 2633
+ DC D SDE +C S C +FRC G C+ S RC+ DCAD SDE+NC NT
Sbjct: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQ- 311
Query: 2634 YKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN-KHKCEENYFSCPSG 2692
F+ N C+ +C+G NDCGD SDE P QN + + E + +G
Sbjct: 312 ----CALDQFLCWNGR--CIGQRKLCNGVNDCGDNSDE--SPQQNCRPRTGEENCNVNNG 363
Query: 2693 RCILNTWICDGQKDC---------EDGR---------DEFHCDSSCS 2721
C + G C EDG +E +C C+
Sbjct: 364 GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410
Score = 119 bits (297), Expect = 9e-26
Identities = 93/372 (25%), Positives = 159/372 (42%), Gaps = 59/372 (15%)
Query: 125 CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGY 184
C + C + C C G ++ DG++C E + + + R
Sbjct: 1320 CSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIR-------------- 1365
Query: 185 LMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNE 244
+ ++ +D + + V LN SV+G +T F
Sbjct: 1366 ---------RISLDTSDHTDV-------HVPVPELNNVISLDYDSVDGKVYYTDVF---- 1405
Query: 245 DMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVG 304
L I+ G E I + +A+DW+ RNLY+ D
Sbjct: 1406 --------------LDVIRRADLNGSNMETVIG--RGLKTTDGLAVDWVARNLYWTDTGR 1449
Query: 305 DRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRI 364
+ I +GS LI+ L P+AIAV P G LF+TD+G++AK+ER ++DG R +
Sbjct: 1450 NTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVL 1509
Query: 365 IDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFED 424
I++ P L LD + +YWVD +LD + D GK R ++ V H + +T +
Sbjct: 1510 INTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQDR 1567
Query: 425 YLYATNSDNYNIVRINRFNGTDIHS-LIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMP 483
++Y T+ +I R+++++G + + L +E I + + Q ++AC V+
Sbjct: 1568 WIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVN----N 1621
Query: 484 GGCSHICLLSSS 495
GGC+H+C +S
Sbjct: 1622 GGCTHLCFARAS 1633
Score = 116 bits (291), Expect = 5e-25
Identities = 93/352 (26%), Positives = 150/352 (42%), Gaps = 33/352 (9%)
Query: 3852 GTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDH 3911
G CSH C+ + C C Q + + + S + L ++ I + DH
Sbjct: 1318 GGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLD---TSDH 1374
Query: 3912 QQIS-HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKR 3970
+ + + + +D Y D ++ T +F I + +N + +
Sbjct: 1375 TDVHVPVPELNNVISLD-YDSVDGKVYYTD-----VFLDVIRRADLNGSNMETVIGRGLK 1428
Query: 3971 PRD-IAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 4029
D +AVDWVA N+YWTD R +I +L+G L+ N EP
Sbjct: 1429 TTDGLAVDWVARNLYWTDTGRN---------------TIEASRLDGSCRKVLINNSLDEP 1473
Query: 4030 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 4089
AIAV P++G ++WT G + IE A +DG+ R++L+ +L P GL +DY + RIYW D
Sbjct: 1474 RAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVD 1533
Query: 4090 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSV 4148
L I S +G V VS + HP + + +IY + RV K+ +
Sbjct: 1534 AHLDRIESADLNGKLRQVLVSH---VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
Query: 4149 EYLALNIDKTKGVLISHRYKQLDLPNPC--LDLACEFLCLLNPSGATCVCPE 4198
E + N++ +++ +Q N C + C LC S C CP+
Sbjct: 1591 ETVLANVEGLMDIIVVSPQRQTG-TNACGVNNGGCTHLCFARASDFVCACPD 1641
Score = 104 bits (259), Expect = 2e-21
Identities = 66/193 (34%), Positives = 93/193 (48%), Gaps = 23/193 (11%)
Query: 792 QQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFR 851
+ G+ MC ++G C G C D+Q + N TT +C A +FR
Sbjct: 232 RSGEFMC--DSGLCINAGWRCDGDADC---DDQSDERNCTTS----------MCTAEQFR 276
Query: 852 CKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPD---DQFKCQNNRCIPKRWLCDGA 908
C + C++ W+CDG+DDC D SDE+ NC N P DQF C N RCI +R LC+G
Sbjct: 277 CHSGRCVRLSWRCDGEDDCADNSDEE--NCENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
Query: 909 NDCGSNEDES-NQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTC 967
NDCG N DES Q C RT + + + NG C + + C T + + TC
Sbjct: 335 NDCGDNSDESPQQNCRPRTGE-ENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
Query: 968 EPLTQFVCKSGRC 980
+ + + + G C
Sbjct: 394 QDVNE-CAEEGYC 405
Score = 101 bits (252), Expect = 1e-20
Identities = 89/353 (25%), Positives = 135/353 (38%), Gaps = 30/353 (8%)
Query: 3852 GTCSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909
G CSH C+ + C C ++ + L A DI Y
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFA 1070
Query: 3910 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFK 3969
D +I + I + V Q + WS ++ + +I +
Sbjct: 1071 DVVVPINITMKNTIA-IGVDPQEGKVYWSDS-----TLHRISRANLDGSQHEDIITTGLQ 1124
Query: 3970 RPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEP 4029
+AVD + +YWTD I VG L+G L+ P
Sbjct: 1125 TTDGLAVDAIGRKVYWTDTGTNR---------------IEVGNLDGSMRKVLVWQNLDSP 1169
Query: 4030 YAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD 4089
AI + + G MYWT G+++ +E + MDG+ R +L+ NL P GL VD S ++ WAD
Sbjct: 1170 RAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWAD 1229
Query: 4090 FELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSV 4148
I + +G+N VS Q HP+ + + + YIY + R K +V
Sbjct: 1230 AHTERIEAADLNGANRHTLVSPVQ---HPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV 1286
Query: 4149 EYLALNIDKTKGVLISHRYKQLDLPNPC--LDLACEFLCLLNPSGATCVCPEG 4199
+ N+ + R + L N C + C LCL PSG +C CP G
Sbjct: 1287 ILVRSNLPGLMDMQAVDRAQPLGF-NKCGSRNGGCSHLCLPRPSGFSCACPTG 1338
Score = 59.3 bits (142), Expect = 9e-08
Identities = 41/128 (32%), Positives = 58/128 (45%), Gaps = 16/128 (12%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P +F C D+ C+ +SW+CDGD DC DDSDE CP +C + C C+
Sbjct: 71 CSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDE--QDCPPR---ECEEDEFPC-QNGYCI 123
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
C+G DC D DE C + ++ C + + YC DG +DG
Sbjct: 124 RSLWHCDGDNDCGDNSDE--QCDMRKCSDKEFRCSDGSCIAEH---WYC-DGDTDCKDG- 176
Query: 152 SCKDQDEC 159
D++ C
Sbjct: 177 --SDEENC 182
Score = 57.4 bits (137), Expect = 3e-07
Identities = 45/149 (30%), Positives = 58/149 (38%), Gaps = 30/149 (20%)
Query: 32 CDPGEFLCH----DHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIAC 84
C F C TC+ W CDGD DC D SDE L TC ++ C
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTC-SPLDFHC------- 78
Query: 85 LGTNKCVHLSQLCNGVLDCPDGYDE----GVHCQELLSNCQQLNCQYKCTMVRNSTRC-- 138
KC+ S +C+G DC D DE C+E CQ C +R+ C
Sbjct: 79 -DNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYC------IRSLWHCDG 131
Query: 139 --YCEDGFEITEDGRSCKDQDECAVYGTC 165
C D + D R C D++ G+C
Sbjct: 132 DNDCGDNSDEQCDMRKCSDKEFRCSDGSC 160
Score = 40.4 bits (93), Expect = 0.041
Identities = 59/247 (23%), Positives = 83/247 (33%), Gaps = 58/247 (23%)
Query: 4183 FLCLLNPSGATCVCPEGKYLINGT--CNDDSLLDDSCKLTCE------NGGRCILNE--- 4231
F C ++ G C C ++ +G C D S D TC + G+CI
Sbjct: 32 FTCAVSALGE-CTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVC 90
Query: 4232 KGDLRCHCWPSYSGERCEVNHCSNY---CQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV 4288
GD C + C C CQNG C+ S+ + + C
Sbjct: 91 DGDNDCE--DDSDEQDCPPRECEEDEFPCQNG-YCIRSLWHCDGDNDCGDNSDEQCDMRK 147
Query: 4289 CED--FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECV 4346
C D F + G+CI H YC C DGS E
Sbjct: 148 CSDKEFRCSDGSCIAE-----------------------HWYCDGDTDCK---DGSDEEN 181
Query: 4347 CPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ----------LCD- 4395
CP+ P C +++ +C G CI++ D +C + S C +CD
Sbjct: 182 CPSAVPAPPCNLEE-FQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS 240
Query: 4396 GYCYNGG 4402
G C N G
Sbjct: 241 GLCINAG 247
Score = 39.7 bits (91), Expect = 0.070
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 1/45 (2%)
Query: 3269 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
+P + C +NNGGC+ C + G C C T + L D TC
Sbjct: 350 RPRTGEENCNVNNGGCAQKCQMVRGAVQ-CTCHTGYRLTEDGHTC 393
Score = 38.9 bits (89), Expect = 0.12
Identities = 72/314 (22%), Positives = 100/314 (31%), Gaps = 86/314 (27%)
Query: 4169 QLDLPNPCLDLACEFLCLL---NPSGATC---VCPEGKYLINGT--CNDDSLLDDSCKLT 4220
Q D N C D + E C+L +P C C ++ +G C DDS D
Sbjct: 50 QCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRE 109
Query: 4221 CEN------GGRCILNE---KGDLRCHCWPSYSGERCEVNHCSNY---CQNGGTCVPSVL 4268
CE G CI + GD C S E+C++ CS+ C +G
Sbjct: 110 CEEDEFPCQNGYCIRSLWHCDGDNDCG---DNSDEQCDMRKCSDKEFRCSDGSCIAEHWY 166
Query: 4269 GRPTCSCALGFTGPNCGKTV------CEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQY 4322
C G NC V E+F G CI+ HC + D C
Sbjct: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDI-----YHCDGD---DDCGD 218
Query: 4323 YVCHHYCVNSESCTIGD---------------DGSVECVCPTRYEGPKCEVDKCV----R 4363
+ C + + C G+ DG +C + + C C R
Sbjct: 219 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADC--DDQSDERNCTTSMCTAEQFR 276
Query: 4364 CHGGHCII-------------NKDSEDIFCN-------------CTNGKIASSCQLCDGY 4397
CH G C+ N D E+ C C NG+ +LC+G
Sbjct: 277 CHSGRCVRLSWRCDGEDDCADNSDEEN--CENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
Query: 4398 CYNGGTCQLDPETN 4411
G P+ N
Sbjct: 335 NDCGDNSDESPQQN 348
Score = 32.7 bits (73), Expect = 8.6
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 5/40 (12%)
Query: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV 1215
C +NNGGC++ C VC+CP+ D++ C +V
Sbjct: 1617 CGVNNGGCTHLC-FARASDFVCACPD----EPDSRPCSLV 1651
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 764 bits (1974), Expect = 0.0
Identities = 463/1391 (33%), Positives = 743/1391 (53%), Gaps = 72/1391 (5%)
Query: 1262 IIFSIRHEIRRIDLH--KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319
++++ R ++R +D K + +++V GL + A+DF F+ L+YW+DV E+ I R + ++
Sbjct: 23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNK 82
Query: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEH 1379
+ +++ VV GL +P+GL DW+ +YW DS ++IEV+ LDGSLR L ++
Sbjct: 83 T---ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
Query: 1380 PRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRI 1439
PRAIALDP G ++WTDW P+IE A M G+ R I WPNGLT+D+ E+++
Sbjct: 140 PRAIALDPSSGFMYWTDW-GEVPKIERAGMDGSSRFIIIN--SEIYWPNGLTLDYEEQKL 196
Query: 1440 VWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWT 1499
W DA+ + I+ + DGTN +++G L HPFA++L+ +YWTDW T+++ NK+T
Sbjct: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
Query: 1500 GQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRS-AACACPH 1558
G+ + I P D+ + RQP A NPC ++ G CSH+CL++ + CACP
Sbjct: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDN--GGCSHLCLMSPVKPFYQCACPT 312
Query: 1559 LMKLSSDKKTCYE-MKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASE 1617
+KL + KTC + + LL ARR+++R + +D P F I + DI ID+D E
Sbjct: 313 GVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDI-VLQLEDIRHAIAIDYDPVE 371
Query: 1618 ERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINV 1677
+YWTD + + I+R+FI+G+G + V++ I G+AVDWV+RNLYW + D +I V
Sbjct: 372 GYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTD--RIEV 429
Query: 1678 ARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTDGN---TINMANMDGSNSKILFQNQK 1733
RL+G+++ +I +++P+ + P+ G +YWTD I A +DGS+ +L
Sbjct: 430 TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489
Query: 1734 E-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792
P GL++DY E K+YW + I N DG V+ +++++ T++ ++W
Sbjct: 490 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL--VEDKIPHIFGFTLLGDYVYW 547
Query: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPT 1852
D + KR I+ ++ ++ +K + GSN C NGGCS LCL
Sbjct: 548 TDWQRRSIERVHKRSAEREVII-DQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYR 606
Query: 1853 SETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFA 1912
+ R C C +G+ L + +C E+FL++S IR I LE ++ + +P++G A
Sbjct: 607 PQGLR-CACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEA 664
Query: 1913 VGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDH 1972
+DF ++ IYWTD+ ISRA + + E ++ GL EG+AVDW+ N+YW D
Sbjct: 665 SALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADT 724
Query: 1973 GFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKV 2032
G N IEV++L+G R V++ + LD PR++A+ P +G ++WTEWG P I +A +DGSE+
Sbjct: 725 GTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERT 784
Query: 2033 VLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVF 2092
LV + NG++IDY + +LYW D T+ IE ++ G NRE V++ F + +
Sbjct: 785 TLVP-NVGRANGLTIDYAKRRLYWTDLDTNLIESSNM-LGLNRE-VIADDLPHPFGLTQY 841
Query: 2093 GAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNG 2152
YIYW+D + S+ R +K ++ L + ++ +F+ R+ G N CA NG
Sbjct: 842 QDYIYWTD--WSRRSIERANKTSGQNRTIIQGHLDY-VMDILVFHSSRQSGWNECASSNG 898
Query: 2153 GCKQLCLYRGNSRRTCAC-AHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDE--TNLN 2209
C LCL C C AH L D TC +LL+S ++ + + + ++ ++
Sbjct: 899 HCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDII 958
Query: 2210 SPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLI-KDNWEDRQVIVENV 2268
PI N R A DY+ K ++++ D+ I+ +D + V+V +V
Sbjct: 959 LPIHSLRNVR--------AIDYDPLDK---QLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
Query: 2269 GS--VEGLAYHRAWDT----LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHV 2322
S +E Y + D +YWT T+ I +D G V+ E D P
Sbjct: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG------VVLKGEQDRPRA 1061
Query: 2323 LALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDG 2382
+ ++ + M++TN E+ P I R+ L G +V+ + + P L +D R KL+++D
Sbjct: 1062 VVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADS 1121
Query: 2383 SLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTG--GDTK 2440
L +IE + G+ R V+ S + L V++N+++W D ++ ++ TG G TK
Sbjct: 1122 DLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWID-KQQQMIEKIDMTGREGRTK 1180
Query: 2441 ILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLED 2500
+ + + N PCA NGGC +CL+ +G CSC +LL+D
Sbjct: 1181 VQARIAQLSDIHAVKELN-LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD 1239
Query: 2501 NRCVTKNSSCNAYSEFECGNGE--CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKP 2558
+ +C+ +F C GE CI CDG C+D SDE L C C
Sbjct: 1240 ELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCP--VCSESQFQ 1294
Query: 2559 CYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCAD 2618
C + +CI C+G+ +C D SDE +C+V C +FRCA+G CI + +C+ N+DC+D
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSD 1353
Query: 2619 ASDEKNCNNTD 2629
SDE +C T+
Sbjct: 1354 KSDELDCYPTE 1364
Score = 520 bits (1339), Expect = e-146
Identities = 319/1026 (31%), Positives = 517/1026 (50%), Gaps = 87/1026 (8%)
Query: 1176 CSLNNGGCSNHCSVVPGRGIV-CSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234
C ++NGGCS+ C + P + C+CP G++L ++ KTC+
Sbjct: 286 CGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK--------------------- 324
Query: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYS---LLVPGLRNTI 1291
D ++ + R ++RRI L D++ L + +R+ I
Sbjct: 325 ---------------------DGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
Query: 1292 ALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYW 1351
A+D+ + +YWTD I R + SG + VV +A P+G+ VDW+A N+YW
Sbjct: 364 AIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNLYW 419
Query: 1352 IDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSG 1411
D+ D+IEV +L+G++R LI+ +E PRAI LDP G ++WTDW P+IE A++ G
Sbjct: 420 TDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW-GEIPKIERAALDG 478
Query: 1412 AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471
+ R + + WPNGL +D+ E +I W DA++D I DGT ++ + + H
Sbjct: 479 SDRVVLVN--TSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV--EDKIPH 534
Query: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ--APN 1529
F +L G VYWTDW+ ++ + +K + + +I + DL + + N
Sbjct: 535 IFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLP----DLMGLKATNVHRVIGSN 590
Query: 1530 PCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDI 1589
PCA + G CSH+CL + CACP +L SD KTC + FLL++RR++IR + +
Sbjct: 591 PCA--EENGGCSHLCLY-RPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL 647
Query: 1590 DNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQ 1649
+ N A + + + + +DFD ++ R+YWTDI +TI RAF+NG+ LE V+ +
Sbjct: 648 ETNNNN--VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705
Query: 1650 SIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLY 1708
G+AVDW+ +NLYW ++ +I V++LDG + ++ +D P+ LA P G +Y
Sbjct: 706 YPEGMAVDWLGKNLYW--ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMY 763
Query: 1709 WTDGN---TINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGG 1765
WT+ I+ A MDGS L N GL+IDY + +LYW I N+ G
Sbjct: 764 WTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGL 823
Query: 1766 NLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMK 1825
N EVI ++L LT ++W D + + +K G+N TI++ V+ +
Sbjct: 824 NREVI---ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDIL 880
Query: 1826 VYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSV 1885
V+ Q G N C +NG CS LCL C C Y L + +C +FL++S
Sbjct: 881 VFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQ 940
Query: 1886 HEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKE 1945
I + ++ D ++PI ID+ + +YW D N I +A+ D +
Sbjct: 941 KSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGF 1000
Query: 1946 DIITNGLG------RVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPR 1999
++ + + + +++D + IYWT N+I V RL+G V++ D+PR
Sbjct: 1001 TVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPR 1060
Query: 2000 SIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCD 2058
++ V+PEKG +++T + P I +A LDG+E+ VL G++ P +++D KL+W D
Sbjct: 1061 AVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWAD 1120
Query: 2059 ARTDKIERIDLETGGNREMVLSGSNV-DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDAT 2117
+ +IE DL +G NR +VL SN+ + VF ++YW D+ +
Sbjct: 1121 SDLRRIESSDL-SGANR-IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGR 1178
Query: 2118 ETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCAC-AHGYLA 2176
+ R ++ VK N ++E + CA+DNGGC +CL +G+ C+C H L
Sbjct: 1179 TKVQARIAQLSDIHAVKELN-LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLL 1237
Query: 2177 EDGVTC 2182
+D ++C
Sbjct: 1238 QDELSC 1243
Score = 353 bits (906), Expect = 2e-96
Identities = 215/634 (33%), Positives = 340/634 (53%), Gaps = 31/634 (4%)
Query: 204 PILLIANFETIE-VFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCI 262
P+LL AN + V NG + AT+ + +DF+++ +I W + E + +K
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA--IKRT 78
Query: 263 QITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLID 322
+ K + + +L +A DWL LY+ D +RI V N +GS+ L
Sbjct: 79 EFNKTESVQNVVVSGLLSP----DGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFW 134
Query: 323 LELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNK 382
EL P+AIA+DP +G +++TD+G V K+ER MDG +R II+S+ P L LD +
Sbjct: 135 QELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQ 194
Query: 383 LVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRF 442
+YW D L+++ + G NR V++G + H + +T+FED LY T+ ++I+ N++
Sbjct: 195 KLYWADAKLNFIHKSNLDGTNRQAVVKG-SLPHPFALTLFEDILYWTDWSTHSILACNKY 253
Query: 443 NG---TDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTR 499
G +IHS I + I + ++ QP ++ C +D GGCSH+CL+S
Sbjct: 254 TGEGLREIHS--DIFSPMDIHAFSQQRQPNA-TNPCGID----NGGCSHLCLMSPVKPFY 306
Query: 500 TCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPR 559
C C TG L +G++CK EL L R +R + L+T + ++ +E++ +
Sbjct: 307 QCACPTGVKLLENGKTCKDGATELLLL---ARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
Query: 560 ALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDG 619
A+D+ YIY+ D I R IDG+ + ++ + + +GIAVDW+ NLYWT+ G
Sbjct: 364 AIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTG 423
Query: 620 HRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKA 679
+ I V RL RK L+ ++ PR IV+DP+ G+MYWTDW E + +IE+A
Sbjct: 424 TDR-IEVTRLN--GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGE------IPKIERA 474
Query: 680 WMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739
+DG +R + V + + WPNGL LD+ +YW DA D IE + +GT R+++ + +
Sbjct: 475 ALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK-IP 533
Query: 740 HPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCR 799
H FG + G+YV+WTD+ SI ++ ++E ++ + P L GL+ + + G N C
Sbjct: 534 HIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCA 593
Query: 800 VNNGGCSTLCLAIPGGRVCACADNQLLDENGTTC 833
NGGCS LCL P G CAC L + TC
Sbjct: 594 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Score = 312 bits (799), Expect = 6e-84
Identities = 235/824 (28%), Positives = 390/824 (47%), Gaps = 65/824 (7%)
Query: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
G CS C C+C G+ + D ++C I P A+ I + N +
Sbjct: 597 GGCSHLCLYRPQGLRCACPIGFELISDMKTC---IVPEAFLLFSRRADIRRISLETNNNN 653
Query: 223 KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 282
L+ V E LDF ++ I W + LK I G E + +
Sbjct: 654 VAIPLTGVK--EASALDFDVTDNRIYWTDI-----SLKTISRAFMNGSALEHVVEFGLDY 706
Query: 283 HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFF 342
+ MA+DWL +NLY+ D +RI V +G L+ +L +P+A+A+DP G +++
Sbjct: 707 P--EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYW 764
Query: 343 TDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGK 402
T++G K++R MDG RT ++ + + L +D + +YW DL + + + G
Sbjct: 765 TEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGL 823
Query: 403 NRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK--IENAWGIR 460
NR + + H +G+T ++DY+Y T+ +I R N+ +G + ++I+ ++ I
Sbjct: 824 NREVIAD--DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN-RTIIQGHLDYVMDIL 880
Query: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPK 520
++ Q A G CSH+C L+ C C ++L +D R+C P
Sbjct: 881 VFHSSRQSGWNECA------SSNGHCSHLC-LAVPVGGFVCGCPAHYSLNADNRTCSAPT 933
Query: 521 NELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLI 580
FL + + + M ++ + + + ++PI +L N RA+D+ +Y+ D+ +I
Sbjct: 934 T--FLLF--SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI 989
Query: 581 GRQKIDGTERETILKDDL--DNVE----GIAVDWIGNNLYWTNDGHRKTINVARLEKASQ 634
+ + DG++ T++ + N+E +++D +YWT + INV RL+ +
Sbjct: 990 RKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA-TNVINVTRLD--GR 1046
Query: 635 SRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKM 694
S +L+GE PR +VV+P G+MY+T+ +E +IE+A +DG R++ S +
Sbjct: 1047 SVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS-----PKIERAALDGTEREVLFFSGL 1101
Query: 695 LWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWT 754
P L LD L+W D+ IE L+G +R IV + P GL+ N+++W
Sbjct: 1102 SKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQPVGLTVFENWLYWI 1160
Query: 755 DYMNGSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQ--GDNMCRVNNGGCSTLCLA 811
D I ++D+ E T ++ L + Q + C +NGGCS +CL
Sbjct: 1161 DKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLV 1220
Query: 812 IPGGRV-CACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRH--CIQARWKCDGDD 868
G C+C + +L ++ +C GE P C +F C CI W+CDG
Sbjct: 1221 KGDGTTRCSCPMHLVLLQDELSC----GE--PPTCSPQQFTCFTGEIDCIPVAWRCDGFT 1274
Query: 869 DCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQ 928
+C D SDE +NC C + QF+C + +CI C+G +C DE N C C
Sbjct: 1275 ECEDHSDE--LNC--PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKN--CEV-LCL 1327
Query: 929 VDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ 972
+DQF C NG+CI + CD DC D++DE+ C +PT EP Q
Sbjct: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDEL-DC-YPTEEPAPQ 1369
Score = 304 bits (778), Expect = 2e-81
Identities = 198/678 (29%), Positives = 344/678 (50%), Gaps = 44/678 (6%)
Query: 163 GTCSQTCRNTHGS--YTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220
G CS C + Y C+C G + + ++CK +LL+A + L+
Sbjct: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK-----DGATELLLLARRTDLRRISLD 345
Query: 221 GSKMATLSSVNGNEIHTLDFIYN--EDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
+ + H + Y+ E I W + ++++ I+ + G ++ +
Sbjct: 346 TPDFTDIVLQLEDIRHAIAIDYDPVEGYIYW-----TDDEVRAIRRSFIDGSGSQFVVT- 399
Query: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
+ +A+DW+ RNLY+ D DRI V NG++ LI +L P+AI +DP+ G
Sbjct: 400 -AQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVG 458
Query: 339 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 398
+++TD+G + K+ER +DG +R ++++ P LALD +YW D D + V++
Sbjct: 459 YMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 518
Query: 399 YQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWG 458
G R +++ + + H++G T+ DY+Y T+ +I R+++ + + ++ + G
Sbjct: 519 TDGTGRRVLVEDK-IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMG 577
Query: 459 IRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKR 518
++ + S+ C + GGCSH+CL + C C GF L SD ++C
Sbjct: 578 LK--ATNVHRVIGSNPCAEE----NGGCSHLCLYRP--QGLRCACPIGFELISDMKTCIV 629
Query: 519 PKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSF 578
P E FL + R +R + L T + IP+ + ALDF N IY+ D +
Sbjct: 630 P--EAFLLF--SRRADIRRISLETN-NNNVAIPLTGVKEASALDFDVTDNRIYWTDISLK 684
Query: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
I R ++G+ E +++ LD EG+AVDW+G NLYW + G + I V++L+ Q R+
Sbjct: 685 TISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLD--GQHRQV 741
Query: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698
L+ ++ PR + +DP G+MYWT+W +I++A MDG R V + + N
Sbjct: 742 LVWKDLDSPRALALDPAEGFMYWTEW------GGKPKIDRAAMDGSERTTLVPN-VGRAN 794
Query: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758
GLT+D+ LYW D + IE + G +R+++ +L HPFGL+ + +Y++WTD+
Sbjct: 795 GLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI--ADDLPHPFGLTQYQDYIYWTDWSR 852
Query: 759 GSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIP-GGR 816
SI + + + + T+++ + + ++ +Q G N C +NG CS LCLA+P GG
Sbjct: 853 RSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGF 912
Query: 817 VCACADNQLLDENGTTCT 834
VC C + L+ + TC+
Sbjct: 913 VCGCPAHYSLNADNRTCS 930
Score = 245 bits (625), Expect = 8e-64
Identities = 152/482 (31%), Positives = 249/482 (51%), Gaps = 32/482 (6%)
Query: 2970 DEC-SSGFPCSQQCINT-YGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRK 3027
+EC SS CS C+ G + C C Y + DN ++ S FL+ + I +
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADN----RTCSAPTTFLLFSQKSAINR 946
Query: 3028 ISTD---GSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVH 3084
+ D + L L NV AID+D ++ +YWIDS + + I + +GS V
Sbjct: 947 MVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQ---NMIRKAQEDGSQGFTVV 1003
Query: 3085 NTAVPNA--------LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLS 3136
++VP+ L++D + +YW+ +I V++L+G +++ PR +
Sbjct: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVV 1063
Query: 3137 LDPQAGYLYWIDCCEY-PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN- 3194
++P+ GY+Y+ + E P I R +DGT + V+ + +S+P+AL +D +L+WAD +
Sbjct: 1064 VNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL 1123
Query: 3195 -HIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 3253
IE S++ G++R + + +I + LT+FE+++YW D + + + + T R +
Sbjct: 1124 RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQA 1183
Query: 3254 SWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313
++DI + +H C +NGGCSH+CL+ T C+CP + L D +C
Sbjct: 1184 RIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC 1243
Query: 3314 --LSNCTASQFRCKTDK--CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLC 3369
C+ QF C T + CIP W+CD +C D SDE +CP C +FQC +G C
Sbjct: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-NCPV--CSESQFQCASGQC 1300
Query: 3370 ALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDER 3429
A C+G+ +C D SDE NC+ +CL QF+C N +CI + +C+ DC D+ DE
Sbjct: 1301 IDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCA-NGQCIGKHKKCDHNVDCSDKSDEL 1358
Query: 3430 DC 3431
DC
Sbjct: 1359 DC 1360
Score = 241 bits (615), Expect = 1e-62
Identities = 142/355 (40%), Positives = 198/355 (55%), Gaps = 17/355 (4%)
Query: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 3035
CS C+ +C C G+E+ D K+ E FL+ + +IR+IS T+ +N
Sbjct: 599 CSHLCLYRPQGLRCACPIGFELISD----MKTCIVPEAFLLFSRRADIRRISLETNNNNV 654
Query: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALA 3093
+ G+ A+DFD + IYW D S I+R +NGS ++ V + P +A
Sbjct: 655 AIPLTGVKEASALDFDVTDNRIYWTDISLKT---ISRAFMNGSALEHVVEFGLDYPEGMA 711
Query: 3094 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 3153
VDW+GKNLYW+DT IEVSKL+G + +LV K L PR L+LDP G++YW + P
Sbjct: 712 VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 771
Query: 3154 HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPN 3211
I R MDG+ ++ ++ + R LTIDY RRLYW D N IE SNM G +R + +
Sbjct: 772 KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIAD 830
Query: 3212 QDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPD 3271
D+P LT ++DYIYWTD +S+ RA+KTSG +R + + DI V+HS RQ
Sbjct: 831 -DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSG 889
Query: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKT 3326
++ C +NG CSHLCL P C CP ++ L ADNRTC + T F K+
Sbjct: 890 WNE--CASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
Score = 220 bits (561), Expect = 2e-56
Identities = 120/309 (38%), Positives = 175/309 (56%), Gaps = 6/309 (1%)
Query: 3015 PFLILADHHEIRKI-STDGS-NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINR 3072
P L+ A+ ++R + +T+G N T++ GL + A+DF + IYW D S R
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
Query: 3073 MCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFP 3132
VV P+ LA DW+G+ LYW+D+E IEVS L+G +L + L P
Sbjct: 81 NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
Query: 3133 RDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD 3192
R ++LDP +G++YW D E P I R GMDG+++ ++I ++I P LT+DY ++LYWAD
Sbjct: 141 RAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWAD 200
Query: 3193 E--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLS 3250
N I SN+DG++R V +P ALTLFED +YWTD T S+ +K +G
Sbjct: 201 AKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLRE 260
Query: 3251 LIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAAD 3309
+ + DI + RQP+ + + C I+NGGCSHLCL++P K + CACPT L +
Sbjct: 261 IHSDIFSPMDIHAFSQQRQPNAT-NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN 319
Query: 3310 NRTCLSNCT 3318
+TC T
Sbjct: 320 GKTCKDGAT 328
Score = 218 bits (556), Expect = 8e-56
Identities = 126/344 (36%), Positives = 190/344 (55%), Gaps = 15/344 (4%)
Query: 2978 CSQQCINT--YGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035
CS C+ + Y+C C G ++ +N CK + E L+LA ++R+IS D ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLL-ENGKTCKDGATE--LLLLARRTDLRRISLDTPDF 349
Query: 3036 T---LLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNAL 3092
T L + + + IAID+D E +IYW D R + + +GS V A P+ +
Sbjct: 350 TDIVLQLEDIRHAIAIDYDPVEGYIYWTDDE-VRAIRRSFIDGSGSQFVVTAQIAHPDGI 408
Query: 3093 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEY 3152
AVDW+ +NLYW+DT IEV++LNG IL+S+ L+ PR + LDP GY+YW D E
Sbjct: 409 AVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEI 468
Query: 3153 PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVP 3210
P I R +DG+++ V++ T + P L +DY ++YW D + IE N DG+ R +
Sbjct: 469 PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV 528
Query: 3211 NQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQP 3270
IP + TL DY+YWTD + +S+ R HK S A+R +I + ++ + +R
Sbjct: 529 EDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREVIIDQLPDLMGLKATNVHRV- 586
Query: 3271 DVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 3314
+ + C NGGCSHLCL P + CACP F L +D +TC+
Sbjct: 587 -IGSNPCAEENGGCSHLCLYRP-QGLRCACPIGFELISDMKTCI 628
Score = 180 bits (456), Expect = 3e-44
Identities = 113/299 (37%), Positives = 157/299 (52%), Gaps = 19/299 (6%)
Query: 550 IPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTER-ETILKDDLDNVEGIAVDW 608
I + L + A+DF IY++D + I R + + TE + ++ L + +G+A DW
Sbjct: 45 IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDW 104
Query: 609 IGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDE 668
+G LYWT D I V+ L+ RK L E+ PR I +DP +G+MYWTDW E
Sbjct: 105 LGEKLYWT-DSETNRIEVSNLD--GSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGE-- 159
Query: 669 IDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTH 728
V +IE+A MDG +R I + S++ WPNGLTLD+ LYW DA + I K L+GT+
Sbjct: 160 ----VPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTN 215
Query: 729 RKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFG-LQIY 787
R+ V G L HPF L+ + ++WTD+ SI + T E LR +F + I+
Sbjct: 216 RQAVVKG-SLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG--LREIHSDIFSPMDIH 272
Query: 788 ---DPRKQQGDNMCRVNNGGCSTLCLAIPGGRV--CACADNQLLDENGTTCTFNPGEAL 841
R+ N C ++NGGCS LCL P CAC L ENG TC E L
Sbjct: 273 AFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELL 331
Score = 141 bits (355), Expect = 2e-32
Identities = 100/404 (24%), Positives = 178/404 (44%), Gaps = 55/404 (13%)
Query: 1174 DECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKH 1233
+EC+ +NG CS+ C VP G VC CP LN DN+TC
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAP------------------ 932
Query: 1234 TVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR---DYSLLVPGLRNT 1290
F++FS + I R+ + ++ D L + LRN
Sbjct: 933 -------------------------TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
Query: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAI--EVVVEHGLATPEGLTVDWIAGN 1348
A+D+ LYW D ++ I + + S G + + V ++ P L++D +
Sbjct: 968 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRY 1027
Query: 1349 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408
IYW + I V +LDG ++ G + PRA+ ++P G +++T+ P+IE A+
Sbjct: 1028 IYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAA 1087
Query: 1409 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEY 1468
+ G R+ ++ + P L +D ++ W D+ I S+ G N I+
Sbjct: 1088 LDGTEREVLF--FSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN--RIVLEDSN 1143
Query: 1469 LSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQ-IYHPSRQPQA 1527
+ P ++++ + +YW D + + K + + + +Q AQ D+ + + Q
Sbjct: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR 1203
Query: 1528 PNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYE 1571
+PCA ++ G CSH+CL+ + + C+CP + L D+ +C E
Sbjct: 1204 QHPCAQDN--GGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE 1245
Score = 127 bits (320), Expect = 2e-28
Identities = 59/126 (46%), Positives = 73/126 (57%), Gaps = 5/126 (3%)
Query: 3467 DEANC-DKKTCGPHEFQCKNN--NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCA 3523
DE +C + TC P +F C +CIP WRCD +C D+SDE NC C+ F CA
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
Query: 3524 NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGED 3583
+G C+ C+GD +C D SDE+NCE C DQFRC+NGQCI KCD + DC D
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
Query: 3584 EKSCEP 3589
E C P
Sbjct: 1357 ELDCYP 1362
Score = 123 bits (309), Expect = 4e-27
Identities = 109/375 (29%), Positives = 162/375 (43%), Gaps = 36/375 (9%)
Query: 3838 KNRQCEDLNECLVF-GTCSHQCIN--VEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIAN 3894
+ RQ N C + G CSH C+ V+ Y+C C + N + ++L +A
Sbjct: 276 QQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLAR 335
Query: 3895 DTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIH 3952
TD+ + P +++ Q+ I H I Y + I+ T I I
Sbjct: 336 RTDLRRISLDTP-DFTDIVLQLEDIRHAIAID----YDPVEGYIYWTDDEVRAIRRSFID 390
Query: 3953 GREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQ 4012
G + ++ + P IAVDWVA N+YWTD I V +
Sbjct: 391 G----SGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDR---------------IEVTR 431
Query: 4013 LNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQR 4072
LNG L++ EP AI ++P G MYWT G+ IE AA+DG+ R +LV +L
Sbjct: 432 LNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGW 491
Query: 4073 PTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG 4132
P GLA+DY +IYW D + I + DG+ V V K + H + DY+Y
Sbjct: 492 PNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK--IPHIFGFTLLGDYVYWTD 549
Query: 4133 -PKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNP 4189
+ + RV K E + + G+ ++ ++ + NPC + C LCL P
Sbjct: 550 WQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVIG-SNPCAEENGGCSHLCLYRP 607
Query: 4190 SGATCVCPEGKYLIN 4204
G C CP G LI+
Sbjct: 608 QGLRCACPIGFELIS 622
Score = 115 bits (288), Expect = 1e-24
Identities = 82/256 (32%), Positives = 119/256 (46%), Gaps = 29/256 (11%)
Query: 3961 SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR 4020
SGL+ P+ +A DW+ +YWTD S I V L+G
Sbjct: 92 SGLLSPD-----GLACDWLGEKLYWTD---------------SETNRIEVSNLDGSLRKV 131
Query: 4021 LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY 4080
L +P AIA++P G MYWT G+ IE A MDG+ R I++ + P GL +DY
Sbjct: 132 LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Query: 4081 FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFR 4139
+++YWAD +L+ I DG+N V K L HP + +FED +Y + +
Sbjct: 192 EEQKLYWADAKLNFIHKSNLDGTNRQAVV--KGSLPHPFALTLFEDILYWTDWSTHSILA 249
Query: 4140 VQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA--TCV 4195
K+ + + +I + + +Q + NPC +D C LCL++P C
Sbjct: 250 CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309
Query: 4196 CPEG-KYLING-TCND 4209
CP G K L NG TC D
Sbjct: 310 CPTGVKLLENGKTCKD 325
Score = 110 bits (276), Expect = 2e-23
Identities = 56/127 (44%), Positives = 71/127 (55%), Gaps = 9/127 (7%)
Query: 3545 DERNC--ETSCSKDQFRCSNGQ--CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI 3600
DE +C +CS QF C G+ CIP W+CDG +C+ DE +C P CS ++
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC----PVCSESQFQ 1294
Query: 3601 CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD 3660
CAS CI +L+CNG+ +C D SDE +C C DQFRC N CI CD DC D
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCAN-GQCIGKHKKCDHNVDCSD 1353
Query: 3661 GSDEENC 3667
SDE +C
Sbjct: 1354 KSDELDC 1360
Score = 105 bits (261), Expect = 1e-21
Identities = 101/367 (27%), Positives = 151/367 (41%), Gaps = 43/367 (11%)
Query: 3852 GTCSHQCINVEGSYKCVCDQNFQERNN--TCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909
G CSH C+ +C C F+ ++ TCI + L + DI N +
Sbjct: 597 GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVP---EAFLLFSRRADIRRISLETNNNN 653
Query: 3910 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGRE-KRQANSGLICPEF 3968
++ ++ S +D + I W T + I ++G + GL PE
Sbjct: 654 VAIPLTGVKEAS---ALDFDVTDNRIYW-TDISLKTISRAFMNGSALEHVVEFGLDYPE- 708
Query: 3969 KRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGE 4028
+AVDW+ N+YW D I V +L+G + L+
Sbjct: 709 ----GMAVDWLGKNLYWADTGTNR---------------IEVSKLDGQHRQVLVWKDLDS 749
Query: 4029 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWA 4088
P A+A++P G MYWT G I+ AAMDG+ R LV N+ R GL +DY R+YW
Sbjct: 750 PRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWT 808
Query: 4089 DFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGS 4147
D + ++I S G N V L HP + ++DYIY + + R K +
Sbjct: 809 DLDTNLIESSNMLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 865
Query: 4148 VEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNP-SGATCVCPEGKYLIN 4204
+ ++D +L+ H +Q N C C LCL P G C CP Y +N
Sbjct: 866 RTIIQGHLDYVMDILVFHSSRQSGW-NECASSNGHCSHLCLAVPVGGFVCGCP-AHYSLN 923
Query: 4205 G---TCN 4208
TC+
Sbjct: 924 ADNRTCS 930
Score = 99.8 bits (247), Expect = 6e-20
Identities = 45/102 (44%), Positives = 58/102 (56%), Gaps = 5/102 (4%)
Query: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711
C+ W CDG +C D+SDEL CPV C E+ F C SG+CI C+G +C+D
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPV-----CSESQFQCASGQCIDGALRCNGDANCQDKS 1317
Query: 2712 DEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
DE +C+ C +QF C+ +CI KH CD DC D DE D
Sbjct: 1318 DEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD 1359
Score = 98.6 bits (244), Expect = 1e-19
Identities = 56/138 (40%), Positives = 76/138 (55%), Gaps = 20/138 (14%)
Query: 998 DEVGCVH--SCFDNQFRCSSGR--CIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGC 1053
DE+ C +C QF C +G CIP W CDG +C D SDE +NC C
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCPV--------C 1288
Query: 1054 NGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKA 1113
+ ++FQC G C+ RC+G+ +C+D SDEK C + L D +F C + G+CI K
Sbjct: 1289 SESQFQC-ASGQCIDGALRCNGDANCQDKSDEKNCE-VLCLID---QFRC-ANGQCIGKH 1342
Query: 1114 WVCDGDIDCEDQSDEDDC 1131
CD ++DC D+SDE DC
Sbjct: 1343 KKCDHNVDCSDKSDELDC 1360
Score = 97.8 bits (242), Expect = 2e-19
Identities = 56/137 (40%), Positives = 74/137 (54%), Gaps = 14/137 (10%)
Query: 957 DEMASCEFPTCEPLTQFVCKSGR--CISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCS 1014
DE++ E PTC P QF C +G CI W CD +C D SDE+ C C ++QF+C+
Sbjct: 1239 DELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCA 1296
Query: 1015 SGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCD 1074
SG+CI G C+GD +C D SDE NC C ++F+C +G C+ +CD
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEK--NCE-------VLCLIDQFRC-ANGQCIGKHKKCD 1346
Query: 1075 GEKDCEDGSDEKGCNGT 1091
DC D SDE C T
Sbjct: 1347 HNVDCSDKSDELDCYPT 1363
Score = 92.8 bits (229), Expect = 7e-18
Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 34/177 (19%)
Query: 998 DEVGCVHSCF---DNQFRCSSGRCIPGHWACDGDN-DCGDFSDEAQINCTKEEIHSPAGC 1053
D GC H C D RCS P H D CG+ P C
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSC----PMHLVLLQDELSCGE----------------PPTC 1249
Query: 1054 NGNEFQCHP-DGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINK 1112
+ +F C + +C+P WRCDG +CED SDE C +C +++F C ++G+CI+
Sbjct: 1250 SPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC----PVCS-ESQFQC-ASGQCIDG 1303
Query: 1113 AWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
A C+GD +C+D+SDE +C+ LC + CAN C+ K C+ DC D SDE
Sbjct: 1304 ALRCNGDANCQDKSDEKNCE-VLCLIDQFRCAN--GQCIGKHKKCDHNVDCSDKSDE 1357
Score = 92.0 bits (227), Expect = 1e-17
Identities = 60/162 (37%), Positives = 82/162 (50%), Gaps = 20/162 (12%)
Query: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYG------EDEKSC-EPASPTCSSREYICASD- 3604
C++D CS+ + K DG C +DE SC EP PTCS +++ C +
Sbjct: 1207 CAQDNGGCSHICLV----KGDGTTRCSCPMHLVLLQDELSCGEP--PTCSPQQFTCFTGE 1260
Query: 3605 -GCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSD 3663
CI + +C+G +C D SDE++C C E QF+C + CI C+G +C D SD
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDELNCPV-CSESQFQCAS-GQCIDGALRCNGDANCQDKSD 1318
Query: 3664 EENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
E+NCE +C D+F C N C CD DC D SDE
Sbjct: 1319 EKNCEV---LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 91.3 bits (225), Expect = 2e-17
Identities = 98/372 (26%), Positives = 159/372 (42%), Gaps = 51/372 (13%)
Query: 3846 NECLVF-GTCSHQCINVE-GSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGF 3901
NEC G CSH C+ V G + C C ++ N TC A + L + + I
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTT---FLLFSQKSAINRM 947
Query: 3902 IYPFNYSGDHQQISHIEHNSRITGMD-----VYY--QRDMIIWSTQFNPGGIFYKRIHGR 3954
+ S D H N R D +Y+ R +I Q + F +
Sbjct: 948 VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
Query: 3955 EKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLN 4014
+ +P D+++D + IYWT + T++ INV +L+
Sbjct: 1008 PSQNLEI--------QPYDLSIDIYSRYIYWTCEA------------TNV---INVTRLD 1044
Query: 4015 GPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRP 4073
G + +L P A+ VNP++G MY+T + + S IE AA+DGT R +L L +P
Sbjct: 1045 GRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKP 1104
Query: 4074 TGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGP 4133
LA+D +++WAD +L I S G+N +V S +L P + +FE+++Y
Sbjct: 1105 IALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS--NILQPVGLTVFENWLYWIDK 1162
Query: 4134 KNGVF-RVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDL----PNPCL--DLACEFLCL 4186
+ + ++ G + I + + H K+L+L +PC + C +CL
Sbjct: 1163 QQQMIEKIDMTGREGRTKVQARIAQLSDI---HAVKELNLQEYRQHPCAQDNGGCSHICL 1219
Query: 4187 LNPSGAT-CVCP 4197
+ G T C CP
Sbjct: 1220 VKGDGTTRCSCP 1231
Score = 85.9 bits (211), Expect = 9e-16
Identities = 49/135 (36%), Positives = 68/135 (50%), Gaps = 10/135 (7%)
Query: 2760 TCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCI 2818
TC+ F+C G C+P W CDG +C D SDEL+ C E+ F C + CI
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP------VCSESQFQCASGQCI 1301
Query: 2819 PKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEA 2878
C+ D +C D SDE C C ++F CA+G+C + +CD + DC D SDE
Sbjct: 1302 DGALRCNGDANCQDKSDEK-NCEV-LCLIDQFRCANGQC-IGKHKKCDHNVDCSDKSDEL 1358
Query: 2879 PLNPKCKSAEQSCNS 2893
P + A Q+ N+
Sbjct: 1359 DCYPTEEPAPQATNT 1373
Score = 85.1 bits (209), Expect = 1e-15
Identities = 53/140 (37%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 2792 DELSTAGCAPNNTCDENAFMCHNKV--CIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEE 2849
DELS C TC F C CIP + CD +C D SDE C C +
Sbjct: 1239 DELS---CGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-NCPV--CSESQ 1292
Query: 2850 FSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGL 2909
F CA G+C+ + +C+GD +C D SDE K+ E C F C NG+CI
Sbjct: 1293 FQCASGQCI-DGALRCNGDANCQDKSDE-------KNCEVLCLIDQFRCANGQCIGKHKK 1344
Query: 2910 CDNKDDCGDGSDERNCHINE 2929
CD+ DC D SDE +C+ E
Sbjct: 1345 CDHNVDCSDKSDELDCYPTE 1364
Score = 69.7 bits (169), Expect = 6e-11
Identities = 48/144 (33%), Positives = 60/144 (41%), Gaps = 21/144 (14%)
Query: 3674 CRADEFLCNNSL--CKLHFWVCDGEDDCGDNSDEAPDMCVKFLCP--STRPHRCRNNRIC 3729
C +F C C W CDG +C D+SDE CP S +C + + C
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN-------CPVCSESQFQCASGQ-C 1300
Query: 3730 LQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGD 3789
+ CNG C D SDE +C C D+F C+N +CI +CD DC D
Sbjct: 1301 IDGALRCNGDANCQDKSDEKNCEVL-------CLIDQFRCANGQCIGKHKKCDHNVDCSD 1353
Query: 3790 GSDEQGCRIAPTEYTCEDNVNPCG 3813
SDE C PTE N G
Sbjct: 1354 KSDELDC--YPTEEPAPQATNTVG 1375
Score = 68.9 bits (167), Expect = 1e-10
Identities = 122/502 (24%), Positives = 183/502 (36%), Gaps = 106/502 (21%)
Query: 2928 NECLSKKVSGCSQDCQDLPVS-YKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTY 2986
NEC S CS C +PV + C C + L D +TC P + +
Sbjct: 891 NECASSN-GHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC--------SAPTTFLLFSQK 941
Query: 2987 GTYKCLCTDGYEIQPDNPNGCKSLS----------DEEPFLILADHHEIRKISTDGSNYT 3036
+ D + PD SL D++ + I + + IRK DGS
Sbjct: 942 SAINRMVIDEQQ-SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGS--- 997
Query: 3037 LLKQGLNNVIA-------------IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV 3083
QG V++ + D +IYW + + IN L+G + VV
Sbjct: 998 ---QGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEAT---NVINVTRLDGRSVGVV 1051
Query: 3084 HNTAV--PNALAVDWIGKNLYWSDTEKRI--IEVSKLNGLYPTILVSKRLKFPRDLSLDP 3139
P A+ V+ +Y+++ ++R IE + L+G +L L P L+LD
Sbjct: 1052 LKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDS 1111
Query: 3140 QAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IE 3197
+ G L+W D + I + G N+ V+ ++ I +P+ LT+ LYW D+ IE
Sbjct: 1112 RLGKLFWADS-DLRRIESSDLSGANRIVLEDSNILQPVGLTV--FENWLYWIDKQQQMIE 1168
Query: 3198 FSNMDGSH-RHKVPNQ-----DIPGVIALTLFEDY----------------IYWTDGKTK 3235
+M G R KV + DI V L L ++Y + DG T+
Sbjct: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNL-QEYRQHPCAQDNGGCSHICLVKGDGTTR 1227
Query: 3236 SLSRAHKTSGADRLS---------------------LIYSWHA--ITDIQVYHSYRQ-PD 3271
H D LS + +W T+ + + P
Sbjct: 1228 CSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV 1287
Query: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIP 3331
S+ +G C L C N +D + C C QFRC +CI
Sbjct: 1288 CSESQFQCASGQCIDGAL-------RCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIG 1340
Query: 3332 FWWKCDTVDDCGDGSDEPDDCP 3353
KCD DC D SDE D P
Sbjct: 1341 KHKKCDHNVDCSDKSDELDCYP 1362
Score = 60.5 bits (145), Expect = 4e-08
Identities = 50/156 (32%), Positives = 68/156 (43%), Gaps = 26/156 (16%)
Query: 1046 EIHSPAGCNGNEFQCHPDGNCVPDLWRC--------DGEKDCEDG------SDEKGCNGT 1091
+IH+ N E++ HP C D C DG C DE C G
Sbjct: 1190 DIHAVKELNLQEYRQHP---CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC-GE 1245
Query: 1092 IRLCDHKTKFSCWSTGR--CINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSV 1149
C + +F+C+ TG CI AW CDG +CED SDE +C +C + CA+
Sbjct: 1246 PPTCSPQ-QFTCF-TGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCASGQ-- 1299
Query: 1150 CLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSN 1185
C+ CNG +C D SDE C ++ C+N
Sbjct: 1300 CIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCAN 1335
Score = 49.7 bits (117), Expect = 7e-05
Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 11/95 (11%)
Query: 32 CDPGEFLCHD-HVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
C P +F C + C+ +W CDG +C D SDE CP C + C + +C
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCP-----VCSESQFQC-ASGQC 1300
Query: 91 VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC 125
+ + CNG +C D DE +C E+L Q C
Sbjct: 1301 IDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRC 1333
Score = 37.4 bits (85), Expect = 0.35
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 4010 VGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLR-RILVQK 4068
V NG ++ + A+ G++YW+ V + + I+ + T + +V
Sbjct: 34 VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92
Query: 4069 NLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 4103
L P GLA D+ E++YW D E + I DGS
Sbjct: 93 GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Score = 37.0 bits (84), Expect = 0.45
Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 17/79 (21%)
Query: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCS--------NHLKCSQV 1227
C+ +NGGCS+ C V CSCP L L +D +C CS + C V
Sbjct: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
Query: 1228 ---------CEQHKHTVKC 1237
CE H + C
Sbjct: 1267 AWRCDGFTECEDHSDELNC 1285
Score = 33.9 bits (76), Expect = 3.8
Identities = 31/131 (23%), Positives = 53/131 (40%), Gaps = 23/131 (17%)
Query: 3757 YKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDA 3816
Y+ PC +D CS+ + GDG+ C P + CG+
Sbjct: 1202 YRQHPCAQDNGGCSHICLVK-----------GDGTTRCSC---PMHLVLLQDELSCGEPP 1247
Query: 3817 YCNQIKTSVF---CRCKPGFQRNMKNRQCEDLNECLVFGTCSH---QCIN---VEGSYKC 3867
C+ + + F C P R +CED ++ L CS QC + ++G+ +C
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRC 1307
Query: 3868 VCDQNFQERNN 3878
D N Q++++
Sbjct: 1308 NGDANCQDKSD 1318
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 747 bits (1929), Expect = 0.0
Identities = 464/1397 (33%), Positives = 720/1397 (51%), Gaps = 68/1397 (4%)
Query: 1252 CTSVDPFEAFIIFSIRHEIRRIDLH--KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVE 1309
C + ++F+ R ++R +D K + +++V GL + A+DF F++ +YWTDV E
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 1310 DRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLR 1369
+ I + L+++G +A++ VV GL +P+GL DW+ +YW DS ++IEVA L+G+ R
Sbjct: 85 EAIKQTYLNQTG--AAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Query: 1370 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNG 1429
L ++ PRAIALDP +G ++WTDW PRIE A M G+ RK I WPNG
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDW-GETPRIERAGMDGSTRKIIVD--SDIYWPNG 199
Query: 1430 LTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRT 1489
LT+D E+++ W DA+ I+ A DG+ +++ G L+HPFA++L G +YWTDW+T
Sbjct: 200 LTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQT 257
Query: 1490 NTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHN 1549
++ NK TG I P D+Q+ RQP C + G CSH+CL++ +
Sbjct: 258 RSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRC--EEDNGGCSHLCLLSPS 315
Query: 1550 RS-AACACPHLMKLSSDKKTCYE-MKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDD 1607
CACP ++L + +TC ++ LL ARR+++R + +D P F I V DI
Sbjct: 316 EPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDI-VLQVDDIRH 374
Query: 1608 VTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWIS 1667
ID+D E +YWTD + + I+RA+++G+G +T+++ +I G+AVDWV+RNLYW
Sbjct: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 1668 SEFDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGS 1723
+ D +I V RL+G S K + +D+P+ +A HPV G +YWTD I AN+DG
Sbjct: 435 TGTD--RIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQ 492
Query: 1724 NSKILFQ-NQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATA 1782
++L + P GL++D E KLYW + I N+DG + ++++L
Sbjct: 493 ERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL--LEDKLPHIFG 550
Query: 1783 LTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNN 1842
T++ ++W D + K I+ ++ ++ +K + G+N C N
Sbjct: 551 FTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRN 609
Query: 1843 GGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDA 1902
GGCS LC T TR C C +G L + +C E+FL+++ I I LE ++ D
Sbjct: 610 GGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNN-DV 667
Query: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDW 1962
+P++G A +DF N+ IYWTD+ ISRA + + E ++ GL EG+AVDW
Sbjct: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDW 727
Query: 1963 IAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIG 2022
+ N+YW D G N IEVARL+G FR V++ + LD PRS+A+ P KG ++WTEWG P I
Sbjct: 728 MGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIV 787
Query: 2023 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGS 2082
+A +DG+ + LV + N ++IDY + +LYW D T+ IE ++ G +V++
Sbjct: 788 RAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNML--GQERVVIADD 844
Query: 2083 NVDMFSVAVFGAYIYWSD-RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVRE 2141
F + + YIYW+D H S+ R K ++ L + ++ +F+ R+
Sbjct: 845 LPHPFGLTQYSDYIYWTDWNLH---SIERADKTSGRNRTLIQGHLDF-VMDILVFHSSRQ 900
Query: 2142 KGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLYSGRTILKSI 2200
G N C +NG C QLCL R C CA Y L C +LL+S ++ + +
Sbjct: 901 DGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM 959
Query: 2201 HLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWED 2260
+ D+ + I P R K A DY+ K I++ D NI+ KD+
Sbjct: 960 -IPDDQHSPDLILPLHGLRNVK-----AIDYDPLDK---FIYWVDGR-QNIKRAKDDGTQ 1009
Query: 2261 RQVIVE-NVG-----SVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITM 2314
V+ + G L+ TL+WT T++I H + G V+
Sbjct: 1010 PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG------VVLR 1063
Query: 2315 SEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRA 2374
+ D P + ++ + +++TN ++ I R+ L G +V+ +T ++ P L +D
Sbjct: 1064 GDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTL 1123
Query: 2375 EKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKY 2434
KL++ D L +IE C+ G+ R + + L L + +++W D ++ I R K
Sbjct: 1124 GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKT 1183
Query: 2435 TGGDTKILRSDIPHQPMGIIAVAN-DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRG 2493
TG ++ + H GI AV PCA NGGC +C+ +G CSC
Sbjct: 1184 TGDKRTRIQGRVAHL-TGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPV 1242
Query: 2494 DRILLEDNRCVTKNSSCNAYSEFECGNGE--CIDYQLTCDGIPHCKDKSDEKLLYCENRS 2551
+LL++ + +C+ +F C GE CI CDG P C D+SDE+ C
Sbjct: 1243 HLVLLQNLLTCGEPPTCSP-DQFACATGEIDCIPGAWRCDGFPECDDQSDEE--GCP--V 1297
Query: 2552 CRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCN 2611
C PC +C+ CDGE DC D SDE DC + C +FRCA G C+ +C+
Sbjct: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCD 1356
Query: 2612 QNIDCADASDEKNCNNT 2628
DC D SDE C T
Sbjct: 1357 SFPDCIDGSDELMCEIT 1373
Score = 498 bits (1283), Expect = e-140
Identities = 325/952 (34%), Positives = 485/952 (50%), Gaps = 56/952 (5%)
Query: 1552 AACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVI 1611
A C CP S LL+A R ++R VD + V ++D +
Sbjct: 21 ALCGCPAPAAASP----------LLLFANRRDVRLVDAGGVKLE--STIVVSGLEDAAAV 68
Query: 1612 DFDASEERLYWTDIKTQTIKRAFINGTG--LETVISRDIQSIRGLAVDWVSRNLYWISSE 1669
DF S+ +YWTD+ + IK+ ++N TG ++ V+ + S GLA DWV + LYW SE
Sbjct: 69 DFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSE 128
Query: 1670 FDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTD-GNT--INMANMDGSNS 1725
+ +I VA L+G S K +D+P+ +A P G +YWTD G T I A MDGS
Sbjct: 129 TN--RIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTR 186
Query: 1726 KILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALT 1784
KI+ + P GL+ID E KLYW + I+R NLDG + + ++ LT ALT
Sbjct: 187 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV--VEGSLTHPFALT 244
Query: 1785 IMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNS-CQLNNG 1843
+ L+W D + C+KR G + + + ++V +E Q ++ C+ +NG
Sbjct: 245 LSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNG 304
Query: 1844 GCSQLCLPT-SETTRTCMCTVGYYLQKNRMSCQ-GIESFLMYSVHEGIRGIPLEPSDKMD 1901
GCS LCL + SE TC C G LQ N +C+ G E L+ + +R I L+ D D
Sbjct: 305 GCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364
Query: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVD 1961
++ + A+ ID+ +YWTD I RA D + + ++ + +GIAVD
Sbjct: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424
Query: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021
W+A N+YWTD G + IEV RLNG+ R +++S+ LD+PR+IA+HP GL++WT+WG+ P I
Sbjct: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKI 484
Query: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081
A LDG E+ VLV+ + WPNG+++D +E KLYW DA+TDKIE I+++ G R +L
Sbjct: 485 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTLLED 543
Query: 2082 SNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVRE 2141
+F + G +IYW+D S+ R HK A+ + + +L +K N +
Sbjct: 544 KLPHIFGFTLLGDFIYWTD--WQRRSIERVHKVKASRDVII--DQLPDLMGLKAVNVAKV 599
Query: 2142 KGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLYSGRTILKSI 2200
GTN CA NGGC LC + ++ R C C G L D TC+ E +L+++ R + I
Sbjct: 600 VGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRI 658
Query: 2201 HLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWED 2260
L ETN N P K AL FD + N I+++D I N
Sbjct: 659 SL--ETNNNDVAIPLTG---VKEASALDFDVS-----NNHIYWTDVSLKTISRAFMNGSS 708
Query: 2261 RQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDH 2319
+ +VE + EG+A LYW + T+ I +D G F V+ + D+
Sbjct: 709 VEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLD----GQF--RQVLVWRDLDN 762
Query: 2320 PHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYF 2379
P LALD + ++WT W + P I+R+ + G N +V + N LTIDY ++LY+
Sbjct: 763 PRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYW 820
Query: 2380 SDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDT 2439
+D IE G +R VI P F L Y +YI+W+DW +I R++K +G +
Sbjct: 821 TDLDTNMIESSNMLGQERVVIADDLPHPF-GLTQYSDYIYWTDWNLHSIERADKTSGRNR 879
Query: 2440 KILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 2491
+++ + + I V + + L+ C NG C LCL P G C C
Sbjct: 880 TLIQGHLDF--VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGH-RCGC 928
Score = 495 bits (1275), Expect = e-139
Identities = 314/1024 (30%), Positives = 495/1024 (48%), Gaps = 86/1024 (8%)
Query: 1176 CSLNNGGCSNHCSVVPGRGI-VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234
C +NGGCS+ C + P C+CP G+QL + +TC+
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-------------------- 338
Query: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYS---LLVPGLRNTI 1291
E ++ + R ++RRI L D++ L V +R+ I
Sbjct: 339 ----------------------GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAI 376
Query: 1292 ALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYW 1351
A+D+ + +YWTD I R L SG + +V + P+G+ VDW+A N+YW
Sbjct: 377 AIDYDPLEGYVYWTDDEVRAIRRAYLDGSGA----QTLVNTEINDPDGIAVDWVARNLYW 432
Query: 1352 IDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSG 1411
D+ D+IEV +L+G+ R L++ ++ PRAIAL P G+++WTDW N P+IE A++ G
Sbjct: 433 TDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN-PKIECANLDG 491
Query: 1412 AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471
R+ + + WPNGL +D E ++ W DA++D I DGT ++ + L H
Sbjct: 492 QERRVLVN--ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLL--EDKLPH 547
Query: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPC 1531
F +L G +YWTDW+ ++ + +K +I + L+ + ++ NPC
Sbjct: 548 IFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQL-PDLMGLKAVNVAK-VVGTNPC 605
Query: 1532 AANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDN 1591
A D G CSH+C + + C CP ++L SD KTC + FL++ R+ I + ++
Sbjct: 606 A--DRNGGCSHLCFFTPH-ATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLET 662
Query: 1592 PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSI 1651
N A + + + + +DFD S +YWTD+ +TI RAF+NG+ +E V+ +
Sbjct: 663 N--NNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP 720
Query: 1652 RGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWT 1710
G+AVDW+ +NLYW ++ +I VARLDG + ++ +D P+ LA P +G +YWT
Sbjct: 721 EGMAVDWMGKNLYW--ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWT 778
Query: 1711 DGN---TINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
+ I A MDG+N L L+IDY + +LYW I N+ G
Sbjct: 779 EWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 838
Query: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
VI ++L LT ++W D NL + K GRN T+++ V+ + V+
Sbjct: 839 VVI---ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVF 895
Query: 1828 DKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHE 1887
Q G N C NNG C QLCL R C C Y L + +C +FL++S
Sbjct: 896 HSSRQDGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLLFSQKS 954
Query: 1888 GIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI 1947
I + + D ++P+ G ID+ + IYW D G I RAK D T +
Sbjct: 955 AISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVL 1013
Query: 1948 ITNGLG-----RVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIA 2002
+ G + +++D + ++WT N I V RL+G V++ D+PR+I
Sbjct: 1014 TSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIV 1073
Query: 2003 VHPEKGLLFWTEWGQMPC-IGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDART 2061
V+ E+G L++T I +A LDG+E+ VL + G+ P + +D KL+W DA
Sbjct: 1074 VNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADL 1133
Query: 2062 DKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETIT 2121
+IE DL +G NR + + V + + G ++YW DR + R K + T
Sbjct: 1134 KRIESCDL-SGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQ--MIERVEKTTGDKR-T 1189
Query: 2122 MRTGLGVNLKEVKIFNRV--REKGTNVCARDNGGCKQLCLYRGNSRRTCAC-AHGYLAED 2178
G +L + V E + CARDNGGC +C+ +G+ C+C H L ++
Sbjct: 1190 RIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQN 1249
Query: 2179 GVTC 2182
+TC
Sbjct: 1250 LLTC 1253
Score = 336 bits (862), Expect = 3e-91
Identities = 207/637 (32%), Positives = 325/637 (51%), Gaps = 26/637 (4%)
Query: 199 PTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNE-IHTLDFIYNEDMICWIESRESSN 257
P P+LL AN + + G K+ + V+G E +DF +++ + W + E +
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA- 86
Query: 258 QLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVC 317
+K + + G I+ L S +A DW+ + LY+ D +RI V N NG+
Sbjct: 87 -IKQTYLNQTGAAVQNVVISGLVS---PDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Query: 318 VTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALAL 377
L +L P+AIA+DP G +++TD+G ++ER MDG R I+DS P L +
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
Query: 378 DLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIV 437
DL + +YW D L ++ + G R V++G + H + +T+ D LY T+ +I
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG-SLTHPFALTLSGDTLYWTDWQTRSIH 261
Query: 438 RIN-RFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSY 496
N R G L + + I++ + QP + CE D GGCSH+CLLS S
Sbjct: 262 ACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEED----NGGCSHLCLLSPSE 316
Query: 497 KTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLV 556
TC C TG L +GR+CK E+ L R +R + L+T + ++ ++++
Sbjct: 317 PFYTCACPTGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIR 373
Query: 557 NPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWT 616
+ A+D+ Y+Y+ D I R +DG+ +T++ ++++ +GIAVDW+ NLYWT
Sbjct: 374 HAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWT 433
Query: 617 NDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRI 676
+ G + I V RL SRK L+ ++ PR I + PV G MYWTDW E+ +I
Sbjct: 434 DTGTDR-IEVTRLN--GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENP------KI 484
Query: 677 EKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGR 736
E A +DG R++ V + + WPNGL LD LYW DA D IE + ++GT R+ + +
Sbjct: 485 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK 544
Query: 737 ELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDN 796
L H FG + G++++WTD+ SI ++ + + ++ + P L GL+ + K G N
Sbjct: 545 -LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTN 603
Query: 797 MCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTC 833
C NGGCS LC P C C L + TC
Sbjct: 604 PCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 640
Score = 317 bits (811), Expect = 2e-85
Identities = 208/677 (30%), Positives = 344/677 (50%), Gaps = 43/677 (6%)
Query: 163 GTCSQTCRNTHGS--YTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220
G CS C + YTC+C G +Q + R+CKA E +LL+A + L+
Sbjct: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEE-----VLLLARRTDLRRISLD 358
Query: 221 GSKMATLSSVNGNEIHTLDFIYN--EDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
+ + H + Y+ E + W + ++++ I+ G + +N
Sbjct: 359 TPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTD-----DEVRAIRRAYLDGSGAQTLVNT 413
Query: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
++ +A+DW+ RNLY+ D DRI V NG+ L+ +L P+AIA+ P+ G
Sbjct: 414 --EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMG 471
Query: 339 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 398
+++TD+G K+E ++DG R ++++ P LALDL +YW D D + V++
Sbjct: 472 LMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
Query: 399 YQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWG 458
G R T+++ + + H++G T+ D++Y T+ +I R+++ + + ++ + G
Sbjct: 532 VDGTKRRTLLEDK-LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMG 590
Query: 459 IRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKR 518
++ V ++ C GGCSH+C + + TR C C G L SD ++C
Sbjct: 591 LKAV--NVAKVVGTNPCA----DRNGGCSHLCFF-TPHATR-CGCPIGLELLSDMKTCIV 642
Query: 519 PKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSF 578
P E FL + R I R + L T ++ IP+ + ALDF N+IY+ D +
Sbjct: 643 P--EAFLVF-TSRAAIHR-ISLETN-NNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLK 697
Query: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
I R ++G+ E +++ LD EG+AVDW+G NLYW + G + I VARL+ Q R+
Sbjct: 698 TISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNR-IEVARLD--GQFRQV 754
Query: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698
L+ ++ +PR + +DP G++YWT+W RI +A+MDG N V K+ N
Sbjct: 755 LVWRDLDNPRSLALDPTKGYIYWTEW------GGKPRIVRAFMDGTNCMTLV-DKVGRAN 807
Query: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758
LT+D+ LYW D + IE + G R ++ +L HPFGL+ + +Y++WTD+
Sbjct: 808 DLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSDYIYWTDWNL 865
Query: 759 GSIFQLDLITS-EVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRV 817
SI + D + TL++ + + ++ +Q G N C NNG C LCLAIPGG
Sbjct: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR 925
Query: 818 CACADNQLLDENGTTCT 834
C CA + LD + C+
Sbjct: 926 CGCASHYTLDPSSRNCS 942
Score = 279 bits (714), Expect = 4e-74
Identities = 221/814 (27%), Positives = 374/814 (45%), Gaps = 65/814 (7%)
Query: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
G CS C T + C C G + D ++C I P A I + N
Sbjct: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTC---IVPEAFLVFTSRAAIHRISLETNNND 666
Query: 223 KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 282
L+ V E LDF + + I W + LK I G + E + +
Sbjct: 667 VAIPLTGVK--EASALDFDVSNNHIYWTDV-----SLKTISRAFMNGSSVEHVVEFGLDY 719
Query: 283 HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFF 342
+ MA+DW+ +NLY+ D +RI V +G L+ +L NP+++A+DP G +++
Sbjct: 720 P--EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYW 777
Query: 343 TDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGK 402
T++G ++ R MDG N ++D K + L +D ++ +YW DL + + + G+
Sbjct: 778 TEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQ 836
Query: 403 NRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK--IENAWGIR 460
R V+ + H +G+T + DY+Y T+ + ++I R ++ +G + +LI+ ++ I
Sbjct: 837 ER--VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN-RTLIQGHLDFVMDIL 893
Query: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPK 520
++ Q + D G C +CL C C + + L R+C P
Sbjct: 894 VFHSSRQDGLN------DCMHNNGQCGQLCLAIPG--GHRCGCASHYTLDPSSRNCSPPT 945
Query: 521 NELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLI 580
FL + + + M + + + + ++P+ L N +A+D+ +IY+ D I
Sbjct: 946 T--FLLFSQ--KSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-I 1000
Query: 581 GRQKIDGTERETIL-----KDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQS 635
R K DGT+ + ++ +++D L+WT + TINV RL + ++
Sbjct: 1001 KRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA-TNTINVHRL--SGEA 1057
Query: 636 RKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKML 695
+L G+ PR IVV+ G++Y+T+ + D +IE+A +DG R++ T+ ++
Sbjct: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQ-----DRAAKIERAALDGTEREVLFTTGLI 1112
Query: 696 WPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTD 755
P L +D L+W DA IE L+G +R + + P GL+ G +++W D
Sbjct: 1113 RPVALVVDNTLGKLFWVDADLKRIESCDLSGANR-LTLEDANIVQPLGLTILGKHLYWID 1171
Query: 756 YMNGSIFQLDLITSEV-TLLRHERPPLFGLQIYD--PRKQQGDNMCRVNNGGCSTLCLAI 812
I +++ T + T ++ L G+ + ++ + C +NGGCS +C+A
Sbjct: 1172 RQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAK 1231
Query: 813 PGGRV-CACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRH--CIQARWKCDGDDD 869
G C+C + +L +N TC GE P C +F C CI W+CDG +
Sbjct: 1232 GDGTPRCSCPVHLVLLQNLLTC----GE--PPTCSPDQFACATGEIDCIPGAWRCDGFPE 1285
Query: 870 CLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQV 929
C D SDE+ C QF C +C+ R CDG DC DE++ C A C
Sbjct: 1286 CDDQSDEEGCPV----CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD--CDA-ICLP 1338
Query: 930 DQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCE 963
+QF C +G+C+ CD DC D +DE+ CE
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDEL-MCE 1371
Score = 237 bits (604), Expect = 2e-61
Identities = 146/471 (30%), Positives = 229/471 (48%), Gaps = 30/471 (6%)
Query: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN--- 3034
C Q C+ G ++C C Y + P + N S FL+ + I ++ D +
Sbjct: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRN----CSPPTTFLLFSQKSAISRMIPDDQHSPD 968
Query: 3035 YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV------ 3088
L GL NV AID+D ++FIYW+D + I R +G+ V+ + +
Sbjct: 969 LILPLHGLRNVKAIDYDPLDKFIYWVDGRQ----NIKRAKDDGTQPFVLTSLSQGQNPDR 1024
Query: 3089 -PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWI 3147
P+ L++D + L+W+ I V +L+G +++ PR + ++ + GYLY+
Sbjct: 1025 QPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFT 1084
Query: 3148 DCCEYP-HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYW--ADENHIEFSNMDGS 3204
+ + I R +DGT + V+ T + RP+AL +D +L+W AD IE ++ G+
Sbjct: 1085 NMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGA 1144
Query: 3205 HRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVY 3264
+R + + +I + LT+ ++YW D + + + R KT+G R + +T I
Sbjct: 1145 NRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV 1204
Query: 3265 HSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC--LSNCTASQF 3322
+ S H C +NGGCSH+C+ T C+CP + L + TC C+ QF
Sbjct: 1205 EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQF 1264
Query: 3323 RCKTDK--CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGEN 3380
C T + CIP W+CD +C D SDE + CP C +F C G C CDGE
Sbjct: 1265 ACATGEIDCIPGAWRCDGFPECDDQSDE-EGCPV--CSAAQFPCARGQCVDLRLRCDGEA 1321
Query: 3381 DCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
DC D SDE +CD +CL QF+C Q C+ + +C+ DC D DE C
Sbjct: 1322 DCQDRSDEADCDA-ICLPNQFRCASGQ-CVLIKQQCDSFPDCIDGSDELMC 1370
Score = 224 bits (572), Expect = 1e-57
Identities = 138/355 (38%), Positives = 188/355 (52%), Gaps = 18/355 (5%)
Query: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 3035
CS C T +C C G E+ D K+ E FL+ I +IS T+ ++
Sbjct: 612 CSHLCFFTPHATRCGCPIGLELLSD----MKTCIVPEAFLVFTSRAAIHRISLETNNNDV 667
Query: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALA 3093
+ G+ A+DFD IYW D S I+R +NGS ++ V + P +A
Sbjct: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKT---ISRAFMNGSSVEHVVEFGLDYPEGMA 724
Query: 3094 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 3153
VDW+GKNLYW+DT IEV++L+G + +LV + L PR L+LDP GY+YW + P
Sbjct: 725 VDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP 784
Query: 3154 HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPN 3211
I R MDGTN +++ K+ R LTIDY ++RLYW D N IE SNM G R + +
Sbjct: 785 RIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD 843
Query: 3212 QDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPD 3271
D+P LT + DYIYWTD S+ RA KTSG +R + + DI V+HS RQ
Sbjct: 844 -DLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
Query: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKT 3326
++ CM NNG C LCL PG H C C +++ L +R C T F K+
Sbjct: 903 LND--CMHNNGQCGQLCLAIPG-GHRCGCASHYTLDPSSRNCSPPTTFLLFSQKS 954
Score = 223 bits (569), Expect = 3e-57
Identities = 122/317 (38%), Positives = 180/317 (56%), Gaps = 13/317 (4%)
Query: 3006 GCKSLSDEEPFLILADHHEIRKISTDGSNY--TLLKQGLNNVIAIDFDYREEFIYWIDSS 3063
GC + + P L+ A+ ++R + G T++ GL + A+DF + + +YW D S
Sbjct: 24 GCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVS 83
Query: 3064 RPNGSRINRMCLN--GSDIK--VVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGL 3119
I + LN G+ ++ V+ P+ LA DW+GK LYW+D+E IEV+ LNG
Sbjct: 84 E---EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
Query: 3120 YPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMAL 3179
+L + L PR ++LDP GY+YW D E P I R GMDG+ + +++++ I P L
Sbjct: 141 SRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGL 200
Query: 3180 TIDYVNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSL 3237
TID ++LYWAD + I +N+DGS R KV + ALTL D +YWTD +T+S+
Sbjct: 201 TIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSI 260
Query: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKT-H 3296
+K +G R ++ + ++ DIQV RQP C +NGGCSHLCLL+P + +
Sbjct: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDNGGCSHLCLLSPSEPFY 319
Query: 3297 TCACPTNFYLAADNRTC 3313
TCACPT L + RTC
Sbjct: 320 TCACPTGVQLQDNGRTC 336
Score = 206 bits (524), Expect = 4e-52
Identities = 123/351 (35%), Positives = 182/351 (51%), Gaps = 29/351 (8%)
Query: 2978 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035
CS C+ + Y C C G ++Q DN CK+ ++E L+LA ++R+IS D ++
Sbjct: 306 CSHLCLLSPSEPFYTCACPTGVQLQ-DNGRTCKAGAEE--VLLLARRTDLRRISLDTPDF 362
Query: 3036 T---LLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PN 3090
T L + + IAID+D E ++YW D I R L+GS + + NT + P+
Sbjct: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEV---RAIRRAYLDGSGAQTLVNTEINDPD 419
Query: 3091 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 3150
+AVDW+ +NLYW+DT IEV++LNG ILVS+ L PR ++L P G +YW D
Sbjct: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
Query: 3151 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHK 3208
E P I +DG + V++ + P L +D +LYW D + IE N+DG+ R
Sbjct: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
Query: 3209 VPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGA-----DRLSLIYSWHAITDIQV 3263
+ +P + TL D+IYWTD + +S+ R HK + D+L + A+ +V
Sbjct: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKV 599
Query: 3264 YHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 3314
V + C NGGCSHLC P T C CP L +D +TC+
Sbjct: 600 --------VGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLELLSDMKTCI 641
Score = 175 bits (443), Expect = 1e-42
Identities = 108/313 (34%), Positives = 149/313 (47%), Gaps = 40/313 (12%)
Query: 547 EYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKID--GTERETILKDDLDNVEGI 604
E I + L + A+DF +Y+ D + I + ++ G + ++ L + +G+
Sbjct: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 605 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDW 664
A DW+G LYWT D I VA L SRK L ++ PR I +DP +G+MYWTDW
Sbjct: 114 ACDWVGKKLYWT-DSETNRIEVANLN--GTSRKVLFWQDLDQPRAIALDPAHGYMYWTDW 170
Query: 665 EEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFL 724
E RIE+A MDG R+I V S + WPNGLT+D LYW DA I + L
Sbjct: 171 GETP------RIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANL 224
Query: 725 NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS--------------E 770
+G+ R+ V G L HPF L+ G+ ++WTD+ SI + T +
Sbjct: 225 DGSFRQKVVEG-SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMD 283
Query: 771 VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGR--VCACADNQLLDE 828
+ +L ER P F + C +NGGCS LCL P CAC L +
Sbjct: 284 IQVLSQERQPFFHTR------------CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQD 331
Query: 829 NGTTCTFNPGEAL 841
NG TC E L
Sbjct: 332 NGRTCKAGAEEVL 344
Score = 127 bits (319), Expect = 3e-28
Identities = 95/364 (26%), Positives = 163/364 (44%), Gaps = 21/364 (5%)
Query: 1216 DYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRI-- 1273
D N+ +C Q+C +C C + LD +C+ P F++FS + I R+
Sbjct: 905 DCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCS---PPTTFLLFSQKSAISRMIP 961
Query: 1274 -DLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEH 1332
D H D L + GLRN A+D+ +YW D I R K + G + +
Sbjct: 962 DDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAK--DDGTQPFVLTSLSQ 1018
Query: 1333 GL---ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRY 1389
G P L++D + ++W + I V +L G ++ G + PRAI ++
Sbjct: 1019 GQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAER 1078
Query: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTG-AWPNGLTVDHFEKRIVWTDARSDA 1448
G L++T+ +IE A++ G R+ ++ TG P L VD+ ++ W DA
Sbjct: 1079 GYLYFTNMQDRAAKIERAALDGTEREVLF---TTGLIRPVALVVDNTLGKLFWVDADLKR 1135
Query: 1449 IYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQK 1508
I S G N + + + + P +++ G +YW D + + + K TG + IQ
Sbjct: 1136 IESCDLSGANRLTLEDAN--IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQG 1193
Query: 1509 TSAQPFDLQ-IYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKK 1567
A + + S + + +PCA ++ G CSH+C+ + + C+CP + L +
Sbjct: 1194 RVAHLTGIHAVEEVSLEEFSAHPCARDN--GGCSHICIAKGDGTPRCSCPVHLVLLQNLL 1251
Query: 1568 TCYE 1571
TC E
Sbjct: 1252 TCGE 1255
Score = 125 bits (315), Expect = 7e-28
Identities = 56/120 (46%), Positives = 68/120 (56%), Gaps = 4/120 (3%)
Query: 3475 TCGPHEFQCKNN--NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
TC P +F C +CIP WRCD +C D SDEE C C+ F CA G CV R
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
Query: 3533 WCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
CDG+ DC D SDE +C+ C +QFRC++GQC+ K +CD DC G DE CE P
Sbjct: 1316 RCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKP 1375
Score = 122 bits (306), Expect = 8e-27
Identities = 107/371 (28%), Positives = 160/371 (43%), Gaps = 40/371 (10%)
Query: 3841 QCEDLNECLVFGTCSHQCI--NVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDI 3898
+CE+ N G CSH C+ E Y C C Q ++N + ++VL +A TD+
Sbjct: 298 RCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDL 352
Query: 3899 --LGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREK 3956
+ P +++ Q+ I H I Y + ++ T I + G
Sbjct: 353 RRISLDTP-DFTDIVLQVDDIRHAIAID----YDPLEGYVYWTDDEVRAIRRAYLDGSGA 407
Query: 3957 RQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGP 4016
+ L+ E P IAVDWVA N+YWTD I V +LNG
Sbjct: 408 QT----LVNTEINDPDGIAVDWVARNLYWTDTGTDR---------------IEVTRLNGT 448
Query: 4017 NCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGL 4076
+ L++ EP AIA++P G+MYWT G++ IE A +DG RR+LV +L P GL
Sbjct: 449 SRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGL 508
Query: 4077 AVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKN 4135
A+D ++YW D + I + DG+ + K L H + D+IY +
Sbjct: 509 ALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK--LPHIFGFTLLGDFIYWTDWQRR 566
Query: 4136 GVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGAT 4193
+ RV K S + + + G+ + K + NPC D C LC P
Sbjct: 567 SIERVHKV-KASRDVIIDQLPDLMGLKAVNVAKVVG-TNPCADRNGGCSHLCFFTPHATR 624
Query: 4194 CVCPEGKYLIN 4204
C CP G L++
Sbjct: 625 CGCPIGLELLS 635
Score = 120 bits (301), Expect = 3e-26
Identities = 54/119 (45%), Positives = 71/119 (59%), Gaps = 7/119 (5%)
Query: 3552 SCSKDQFRCSNGQ--CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISA 3609
+CS DQF C+ G+ CIP W+CDG +C DE+ C P CS+ ++ CA C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDL 1313
Query: 3610 SLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCE 3668
L+C+GE DC D SDE DC C +QFRC + C+ I+ CD DC+DGSDE CE
Sbjct: 1314 RLRCDGEADCQDRSDEADCDAICLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMCE 1371
Score = 112 bits (281), Expect = 7e-24
Identities = 215/922 (23%), Positives = 350/922 (37%), Gaps = 155/922 (16%)
Query: 209 ANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAG 268
A + IEV ++G+K TL + H F D I W + + S ++ + KA
Sbjct: 522 AKTDKIEVINVDGTKRRTL--LEDKLPHIFGFTLLGDFIYWTDWQRRS--IERVHKVKA- 576
Query: 269 GLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVC--NSNGSVCVTLIDLELH 326
+ + I+ L ++ + + + D G +C + + C I LEL
Sbjct: 577 --SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELL 634
Query: 327 NPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIID-SKTEQPAALALDLVNKLVY 385
+ + P A F + + A + R ++ N I + ++ +AL D+ N +Y
Sbjct: 635 SDMKTCIVPEA----FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIY 690
Query: 386 WVDLYLDYVGVVDYQGKN-RHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNG 444
W D+ L + G + H V G + LY ++ N + + R +G
Sbjct: 691 WTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGT-NRIEVARLDG 749
Query: 445 TDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCR 504
L+ W R RS A +DP +I K R R
Sbjct: 750 QFRQVLV-----W-------RDLDNPRSLA--LDPTK-----GYIYWTEWGGKPRIVRAF 790
Query: 505 TGFNLGSDGRSCKR------PKNELFLFYGKGRPGIVRGMDLNTKIAD-------EYMIP 551
DG +C N+L + Y R + DL+T + + E ++
Sbjct: 791 M------DGTNCMTLVDKVGRANDLTIDYADQR---LYWTDLDTNMIESSNMLGQERVVI 841
Query: 552 IENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAV----- 606
++L +P L +++ YIY+ D I R T+++ LD V I V
Sbjct: 842 ADDLPHPFGLTQYSD--YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSR 899
Query: 607 -----DWIGNN-------------------LYWTNDGHRKTIN-------------VARL 629
D + NN ++T D + + ++R+
Sbjct: 900 QDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM 959
Query: 630 EKASQSRKTL---LEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNR 686
Q L L G + + + I DP++ ++YW D ++ I++A DG
Sbjct: 960 IPDDQHSPDLILPLHG-LRNVKAIDYDPLDKFIYWVDGRQN--------IKRAKDDG--T 1008
Query: 687 QIFVTSKMLW-------PNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSG-REL 738
Q FV + + P+ L++D ++ TL+W + I L+G +V G R+
Sbjct: 1009 QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDK 1068
Query: 739 NHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDN-- 796
++ Y+++T+ M +++ + T ER LF + P DN
Sbjct: 1069 PRAIVVNAERGYLYFTN-MQDRAAKIERAALDGT----EREVLFTTGLIRPVALVVDNTL 1123
Query: 797 --MCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCK- 853
+ V+ + G D ++ G T G+ L I + + +
Sbjct: 1124 GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL---GKHLYWIDRQQQMIERV 1180
Query: 854 NRHCIQARWKCDGDDDCLDGS---DEDSVNCFN-HSCPDDQFKCQNNRCIPKRWLCDGAN 909
+ R + G L G +E S+ F+ H C D C ++ CI K DG
Sbjct: 1181 EKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC-SHICIAKG---DGTP 1236
Query: 910 DCGSNED----ESNQTC-TARTCQVDQFSCGNGR--CIPRAWLCDREDDCGDQTDEMASC 962
C ++ TC TC DQF+C G CIP AW CD +C DQ+DE
Sbjct: 1237 RCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC- 1295
Query: 963 EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGH 1022
P C QF C G+C+ + CD + DC D SDE C C NQFRC+SG+C+
Sbjct: 1296 --PVCSA-AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
Query: 1023 WACDGDNDCGDFSDEAQINCTK 1044
CD DC D SDE TK
Sbjct: 1353 QQCDSFPDCIDGSDELMCEITK 1374
Score = 106 bits (264), Expect = 6e-22
Identities = 78/276 (28%), Positives = 117/276 (42%), Gaps = 30/276 (10%)
Query: 3940 QFNPGGIFY--------KRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRM 3991
QF+ G +++ K+ + + A ++ P +A DWV +YWTD
Sbjct: 71 QFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTD---- 126
Query: 3992 HWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSH 4051
S I V LNG + L +P AIA++P G MYWT G+
Sbjct: 127 -----------SETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPR 175
Query: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
IE A MDG+ R+I+V ++ P GL +D +++YWAD +LS I DGS V
Sbjct: 176 IERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG 235
Query: 4112 KQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQL 4170
L HP + + D +Y + K G + + + + + + +Q
Sbjct: 236 --SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQP 293
Query: 4171 DLPNPCLD--LACEFLCLLNPSGA--TCVCPEGKYL 4202
C + C LCLL+PS TC CP G L
Sbjct: 294 FFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
Score = 101 bits (252), Expect = 1e-20
Identities = 48/120 (40%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
Query: 3511 KPQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPA 3568
+P TC+ F CA G DC+ + CDG +C D SDE C CS QF C+ GQC+
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-CSAAQFPCARGQCVDL 1313
Query: 3569 KWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC 3628
+ +CDG DC+ DE C+ C ++ CAS C+ +C+ DC DGSDE+ C
Sbjct: 1314 RLRCDGEADCQDRSDEADCD---AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 97.1 bits (240), Expect = 4e-19
Identities = 55/151 (36%), Positives = 86/151 (56%), Gaps = 12/151 (7%)
Query: 1050 PAGCNGNEFQCHP-DGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGR 1108
P C+ ++F C + +C+P WRCDG +C+D SDE+GC +C +F C + G+
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCS-AAQFPC-ARGQ 1309
Query: 1109 CINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSD 1168
C++ CDG+ DC+D+SDE DCD+ +C P + CA+ V ++ + C+ DC DGSD
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQ--CDSFPDCIDGSD 1366
Query: 1169 EGYLCDECSLNNGGCSNHCSVV-PGRGIVCS 1198
E +C+ + H S + P GI+ S
Sbjct: 1367 E-LMCEITKPPSDDSPAHSSAIGPVIGIILS 1396
Score = 91.3 bits (225), Expect = 2e-17
Identities = 68/229 (29%), Positives = 100/229 (43%), Gaps = 23/229 (10%)
Query: 3971 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 4030
P +AVDW+ N+YW D I V +L+G L+ P
Sbjct: 720 PEGMAVDWMGKNLYWADTGTNR---------------IEVARLDGQFRQVLVWRDLDNPR 764
Query: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 4090
++A++P +G +YWT G I A MDGT LV K + R L +DY +R+YW D
Sbjct: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
Query: 4091 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 4149
+ ++I S G VV L HP + + DYIY + + R K +
Sbjct: 824 DTNMIESSNMLGQERVVIADD---LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRT 880
Query: 4150 YLALNIDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGATCVC 4196
+ ++D +L+ H +Q D N C+ + C LCL P G C C
Sbjct: 881 LIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
Score = 89.7 bits (221), Expect = 6e-17
Identities = 42/100 (42%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Query: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711
C+ W CDG +C D SDE CPV C F C G+C+ CDG+ DC+D
Sbjct: 1273 CIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
Query: 2712 DEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
DE CD+ C NQF C++ +C+ CD DC DG DE
Sbjct: 1328 DEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 88.2 bits (217), Expect = 2e-16
Identities = 58/142 (40%), Positives = 69/142 (48%), Gaps = 18/142 (12%)
Query: 2666 GDYSDELKCPV-----QNKHKCEE------NYFSCPSGR--CILNTWICDGQKDCEDGRD 2712
GD + CPV QN C E + F+C +G CI W CDG +C+D D
Sbjct: 1232 GDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSD 1291
Query: 2713 EFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSR 2772
E C CS QF C+ +C+ CDGE DC D DE+D C AI C + F C S
Sbjct: 1292 EEGCPV-CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD--CDAI-CLPNQFRC-ASG 1346
Query: 2773 ACVPRHWLCDGERDCPDGSDEL 2794
CV CD DC DGSDEL
Sbjct: 1347 QCVLIKQQCDSFPDCIDGSDEL 1368
Score = 86.3 bits (212), Expect = 7e-16
Identities = 62/177 (35%), Positives = 85/177 (48%), Gaps = 27/177 (15%)
Query: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYG------EDEKSC-EPASPTCSSREYICASD- 3604
C++D CS+ CI K DG C ++ +C EP PTCS ++ CA+
Sbjct: 1217 CARDNGGCSH-ICIA---KGDGTPRCSCPVHLVLLQNLLTCGEP--PTCSPDQFACATGE 1270
Query: 3605 -GCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSD 3663
CI + +C+G +C D SDE C C QF C + C+ +R CDG DC D SD
Sbjct: 1271 IDCIPGAWRCDGFPECDDQSDEEGCPV-CSAAQFPCA-RGQCVDLRLRCDGEADCQDRSD 1328
Query: 3664 EENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP 3720
E +C+ IC ++F C + C L CD DC D SDE +C T+P
Sbjct: 1329 EADCDA---ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE-------LMCEITKP 1375
Score = 84.7 bits (208), Expect = 2e-15
Identities = 48/133 (36%), Positives = 65/133 (48%), Gaps = 13/133 (9%)
Query: 2799 CAPNNTCDENAFMCHNKV--CIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGR 2856
C TC + F C CIP + CD +C D SDE G C +F CA G+
Sbjct: 1253 CGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE---GCPVCSAAQFPCARGQ 1309
Query: 2857 CLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDC 2916
C ++ + +CDG+ DC D SDEA + C + F C +G+C+ CD+ DC
Sbjct: 1310 C-VDLRLRCDGEADCQDRSDEA-------DCDAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
Query: 2917 GDGSDERNCHINE 2929
DGSDE C I +
Sbjct: 1362 IDGSDELMCEITK 1374
Score = 82.0 bits (201), Expect = 1e-14
Identities = 49/119 (41%), Positives = 60/119 (50%), Gaps = 10/119 (8%)
Query: 2760 TCAADMFSCQ-GSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCI 2818
TC+ D F+C G C+P W CDG +C D SDE GC C F C C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE---EGCP---VCSAAQFPCARGQCV 1311
Query: 2819 PKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 2877
+ CD + DC D SDE+ C C +F CA G+C+L Q QCD DC D SDE
Sbjct: 1312 DLRLRCDGEADCQDRSDEA-DCD-AICLPNQFRCASGQCVLIKQ-QCDSFPDCIDGSDE 1367
Score = 75.1 bits (183), Expect = 2e-12
Identities = 76/314 (24%), Positives = 129/314 (41%), Gaps = 44/314 (14%)
Query: 3969 KRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGE 4028
++P D+++D + ++WT + +INV +L+G +L +
Sbjct: 1024 RQPHDLSIDIYSRTLFWTCEATN---------------TINVHRLSGEAMGVVLRGDRDK 1068
Query: 4029 PYAIAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYW 4087
P AI VN +RG +Y+T + D + IE AA+DGT R +L L RP L VD +++W
Sbjct: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
Query: 4088 ADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVF-RVQKFGHG 4146
D +L I S G+N + + ++ P + I ++Y + + RV+K
Sbjct: 1129 VDADLKRIESCDLSGANRLTLEDA--NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
Query: 4147 SVEYLALNIDKTKGVLISHRYKQLDL----PNPCL--DLACEFLCLLNPSGA-TCVCPEG 4199
+ + G+ H +++ L +PC + C +C+ G C CP
Sbjct: 1187 KRTRIQGRVAHLTGI---HAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVH 1243
Query: 4200 KYLING--------TCNDDSLLDDSCKLTCENGG-RCILNEKGDLRCHCWPSYSGERCEV 4250
L+ TC+ D + ++ C G RC D C E C V
Sbjct: 1244 LVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRC------DGFPECDDQSDEEGCPV 1297
Query: 4251 NHCSNYCQNGGTCV 4264
+ + G CV
Sbjct: 1298 CSAAQFPCARGQCV 1311
Score = 69.7 bits (169), Expect = 6e-11
Identities = 43/129 (33%), Positives = 56/129 (43%), Gaps = 19/129 (14%)
Query: 3674 CRADEFLCNNSL--CKLHFWVCDGEDDCGDNSDEAPDMCVKFLCP--STRPHRCRNNRIC 3729
C D+F C C W CDG +C D SDE CP S C + C
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEG-------CPVCSAAQFPCARGQ-C 1310
Query: 3730 LQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGD 3789
+ C+G +C D SDE C C ++F C++ +C+ + QCD DC D
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAI-------CLPNQFRCASGQCVLIKQQCDSFPDCID 1363
Query: 3790 GSDEQGCRI 3798
GSDE C I
Sbjct: 1364 GSDELMCEI 1372
Score = 57.4 bits (137), Expect = 3e-07
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 15/133 (11%)
Query: 14 LLPIARVLTVGADRDQQLCDPGEFLCHD-HVTCVSQSWLCDGDPDCPDDSDESLDTCPEE 72
L+ + +LT G + C P +F C + C+ +W CDG P+C D SDE + CP
Sbjct: 1244 LVLLQNLLTCG---EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGCP-- 1296
Query: 73 VEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMV 132
C C +CV L C+G DC D DE C + Q +C ++
Sbjct: 1297 ---VCSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDE-ADCDAICLPNQFRCASGQCVLI 1351
Query: 133 RNSTRCY--CEDG 143
+ + C DG
Sbjct: 1352 KQQCDSFPDCIDG 1364
Score = 45.8 bits (107), Expect = 0.001
Identities = 37/133 (27%), Positives = 61/133 (45%), Gaps = 19/133 (14%)
Query: 3963 LICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022
L+ + PR +A+D G IYWT+ W + I ++G NC L+
Sbjct: 755 LVWRDLDNPRSLALDPTKGYIYWTE-------------WGG-KPRIVRAFMDGTNCMTLV 800
Query: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFS 4082
+ G + ++ +YWT + D + IE + M G R+++ +L P GL +S
Sbjct: 801 -DKVGRANDLTIDYADQRLYWTDL-DTNMIESSNMLGQ-ERVVIADDLPHPFGLT--QYS 855
Query: 4083 ERIYWADFELSII 4095
+ IYW D+ L I
Sbjct: 856 DYIYWTDWNLHSI 868
Score = 43.5 bits (101), Expect = 0.005
Identities = 87/408 (21%), Positives = 142/408 (34%), Gaps = 61/408 (14%)
Query: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILV-----QKNLQRPTGLAVDYFSERI 4085
AI +P +YW V +I+ A DGT +L Q ++P L++D +S +
Sbjct: 981 AIDYDPLDKFIYW--VDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTL 1038
Query: 4086 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQK--- 4142
+W + I G V + + ++ Y+Y ++ ++++
Sbjct: 1039 FWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAAL 1098
Query: 4143 --------FGHGSVEYLALNIDKTKGVLI-----SHRYKQLDLPNPCLDLACEFLCLLNP 4189
F G + +AL +D T G L R + DL L E ++ P
Sbjct: 1099 DGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSG-ANRLTLEDANIVQP 1157
Query: 4190 SGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCE 4249
G T + GK+L +++ K T + R H S E
Sbjct: 1158 LGLTIL---GKHLY-WIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS 1213
Query: 4250 VNHCSNYCQNGGT---CVPSVLGRPTCSCALGFT----------GPNCGKTVCEDFCQNG 4296
+ C+ NGG C+ G P CSC + P C + C G
Sbjct: 1214 AHPCAR--DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD--QFACATG 1269
Query: 4297 GT-CIVTA---GNQPYCHCQPEYTG----DRCQYYVCHHYCVNSESCTIGDDGSVECVCP 4348
CI A P C Q + G Q+ CV+ + DG +C
Sbjct: 1270 EIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLR---LRCDGEADC--Q 1324
Query: 4349 TRYEGPKCE---VDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQL 4393
R + C+ + RC G C++ K D F +C +G C++
Sbjct: 1325 DRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
Score = 40.4 bits (93), Expect = 0.041
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 1/102 (0%)
Query: 4028 EPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYW 4087
E A+ + +YWT V + I A M+G+ +V+ L P G+AVD+ + +YW
Sbjct: 676 EASALDFDVSNNHIYWTDVSLKT-ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYW 734
Query: 4088 ADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY 4129
AD + I DG V V +D + YIY
Sbjct: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
Score = 33.9 bits (76), Expect = 3.8
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 1169 EGYLCDECSLNNGGCSNHCSVVPGRGIV-CSCPEGLQLNKDNKTCEIVDYCS 1219
E + C+ +NGGCS+ C + G G CSCP L L ++ TC CS
Sbjct: 1210 EEFSAHPCARDNGGCSHIC-IAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 536 bits (1381), Expect = e-151
Identities = 274/708 (38%), Positives = 397/708 (56%), Gaps = 42/708 (5%)
Query: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
C DQF+C+N RCIP W CD +DC + DE + C +TC F+C NG CI W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 946 CDREDDCGDQTDEM-ASCEFPTCEPLTQFVC--KSGRCISSKWHCDSDDDCGDGSDEVGC 1002
CD E++C D +DE A+C C P + C S +C+ + W CD + DC G+DE GC
Sbjct: 105 CDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1003 VHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHP 1062
C ++F+C + C+ + CDGD+DCGD SDE C PA C EF+C
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCA-----DPA-CGPREFRCGG 215
Query: 1063 DGN--CVPDLWRCDGEKDCEDGSDEK---------GCNGTIRLCDHKTKFSCWSTGRCIN 1111
DG C+P+ W CD + DCED SDE G C ++F+C S G C++
Sbjct: 216 DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS-GECVH 274
Query: 1112 KAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE-G 1170
W CDGD DC+D+SDE DC C + C + T C+ K CN ++DCPDGSDE G
Sbjct: 275 LGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAG 332
Query: 1171 YL--CDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVC 1228
L +EC NNGGCS+ C+ + G C+CP G QL D KTC +D C + CSQ+C
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQIC 390
Query: 1229 EQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLR 1288
+K KC CY G+++D+ ++C + +IF+ RHE+RRIDL KR+YS L+P L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
Query: 1289 NTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN 1348
N +ALD + +YW D+ +IY + ++ EV+++ L +PEGL VDW+ +
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
Query: 1349 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408
IYW DS I VA +DG R TL + + PRAIA+DP G ++W+DW + +IE +
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSG 569
Query: 1409 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEY 1468
++G R+T+ D WPNG+T+D +R+ W D++ + S + G N +I ++
Sbjct: 570 LNGVDRQTLVSD--NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 1469 LSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAP 1528
LSHPF ++++ +V+WTD + AN+ G +S++ + P D+ I+H +QP+AP
Sbjct: 628 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
Query: 1529 NPCAAN-DGKGPCSHMCL-----INHNRSAACACPHLMKLSSDKKTCY 1570
+ C + G C ++CL +H+ CACP M L D K CY
Sbjct: 688 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
Score = 432 bits (1111), Expect = e-120
Identities = 246/697 (35%), Positives = 354/697 (50%), Gaps = 74/697 (10%)
Query: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICD 2740
CE++ F C + RCI + W CD DC D DE C +C+ + F C CI + W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2741 GEDDCGDGLDESDSICGAITCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
GE++C DG DES++ C C A+ SC S CVP W CDGE+DC G+DE AGC
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
Query: 2800 APNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCAD--GRC 2857
A C + F C N+ C+ FVCD DDDCGDGSDE C CG EF C G
Sbjct: 164 A--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGA 220
Query: 2858 LLNTQWQCDGDFDCPDHSDEAPL-----NPKCKSAEQSC-NSSFFMCKNGRCIPSGGLCD 2911
+ +W CD FDC D SDEA P SA +C +S F C++G C+ G CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 2912 NKDDCGDGSDERNCHI-----------------------------------------NEC 2930
DC D SDE +C + NEC
Sbjct: 281 GDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 340
Query: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
L GCS C DL + ++C C GFQL D KTC DIDEC CSQ C+N G +K
Sbjct: 341 LHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFK 398
Query: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
C C GYE+ N CK+ + + P LI + HE+R+I NY+ L L NV+A+D
Sbjct: 399 CECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
Query: 3051 DYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTE 3107
+ IYW D S R S + + +V+ + + P LAVDW+ K++YW+D+
Sbjct: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
Query: 3108 KRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSV 3167
+ I V+ ++G L S+ L PR +++DP G++YW D + I + G++G ++
Sbjct: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
Query: 3168 VIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALTLF 3223
++ I P +T+D +++RLYW D + S++D G+ + + + D + + +F
Sbjct: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
Query: 3224 EDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMINN 3281
ED ++WTD + +++ A++ +G + L + + DI ++H +QP + L + N
Sbjct: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
Query: 3282 GGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
GGC +LCL AP +TCACP +L D + C
Sbjct: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 372 bits (954), Expect = e-102
Identities = 229/723 (31%), Positives = 331/723 (45%), Gaps = 77/723 (10%)
Query: 3515 CTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC-ETSCSKDQFRCSNGQCIPAKWKCD 3573
C F C N C+ S + CD D DC D SDE +C + +C+ F C NG CI +WKCD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICA--SDGCISASLKCNGEYDCADGSDEMDCVTE 3631
G E+C G DE C + + C S C+ AS +C+GE DC G+DE C T
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Query: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNS---LCKL 3688
C +F+C N++ C+ ++CDG DC DGSDE C C EF C C
Sbjct: 167 CAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIP 223
Query: 3689 HFWVCDGEDDCGDNSDEAPDMCVK---------FLCPSTRPHRCRNNRICLQSEQMCNGI 3739
WVCD + DC D SDEA ++C + C + CR+ C+ C+G
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGD 282
Query: 3740 DECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIA 3799
+C D SDE C C+ DEF C + C+ C++ DC DGSDE GC
Sbjct: 283 RDCKDKSDEADC------PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3800 PTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCI 3859
E C N C C +K C C GFQ + + C D++EC CS C+
Sbjct: 337 LNE--CLHNNGGCSH--ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICV 391
Query: 3860 NVEGSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISH 3916
N +G +KC C ++ C A + L N ++ + NYS
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RL 445
Query: 3917 IEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRP 3971
I + +DV + I W + Y++I+ +A+ LI + P
Sbjct: 446 IPMLKNVVALDVEVATNRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 3972 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 4031
+AVDWV +IYWTD +I+V ++G L + EP A
Sbjct: 500 EGLAVDWVHKHIYWTDSGNK---------------TISVATVDGGRRRTLFSRNLSEPRA 544
Query: 4032 IAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFE 4091
IAV+P RG MYW+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +
Sbjct: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
Query: 4092 LSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEY 4150
L + S+ + G N +SS L HP I +FED ++ +N +F + +
Sbjct: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
Query: 4151 LALNIDKTKGVLISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEG 4199
LA N++ ++I H KQ P+ C + CE+LCL P + TC CP+
Sbjct: 665 LAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
Query: 4200 KYL 4202
+L
Sbjct: 725 MWL 727
Score = 248 bits (632), Expect = 1e-64
Identities = 134/343 (39%), Positives = 174/343 (50%), Gaps = 30/343 (8%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN---CI 3489
C+P FQC + C++ ++VCD D DC D SDE C CGP EF+C + CI
Sbjct: 164 ATLCAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
Query: 3490 PDHWRCDSQNDCSDNSDE--ENC---------KPQTC-TLKDFLCANGDCVSSRFWCDGD 3537
P+ W CD Q DC D SDE E C P C T F C +G+CV + CDGD
Sbjct: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGD 282
Query: 3538 FDCADGSDERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSS 3596
DC D SDE +C +C D+F+C +G C+ A C+ +DC G DE C C
Sbjct: 283 RDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 342
Query: 3597 REYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
C+ I LK E C G D+ C + ECK+
Sbjct: 343 NNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 382
Score = 237 bits (604), Expect = 2e-61
Identities = 160/494 (32%), Positives = 241/494 (48%), Gaps = 32/494 (6%)
Query: 36 EFLCHDHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIACLGTNKCVH 92
+F C CV W CDGD DC D SDE+ L TC + E +C G CV
Sbjct: 264 QFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD-EFQC--------GDGTCVL 313
Query: 93 LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDG 150
+ CN DCPDG DE C + L+ C N C + CT ++ C C GF++ D
Sbjct: 314 AIKHCNQEQDCPDGSDEA-GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQ 371
Query: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIAN 210
++C D DEC CSQ C N G + C C GY M ++CKA + P L+ N
Sbjct: 372 KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTN 428
Query: 211 FETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGL 270
+ L + L + N + LD + I W + S ++ + KA
Sbjct: 429 RHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD- 484
Query: 271 TDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKA 330
E + I + H+ + +A+DW+ +++Y+ D I V +G TL L P+A
Sbjct: 485 PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRA 544
Query: 331 IAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLY 390
IAVDP+ G ++++D+G+ AK+E+ ++G++R ++ E P + LDL+++ +YWVD
Sbjct: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
Query: 391 LDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHS 449
L + +D+ G NR T+I + H +GI VFED ++ T+ +N I NR NG +I
Sbjct: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
Query: 450 LIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCR 504
L + + N I I+ + QP ACE+ GGC ++CL +SS TC C
Sbjct: 665 LAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Query: 505 TGFNLGSDGRSCKR 518
LG D + C R
Sbjct: 723 DTMWLGPDMKRCYR 736
Score = 220 bits (561), Expect = 2e-56
Identities = 113/322 (35%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
Query: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3470 NCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLC---ANGD 3526
C C PHEFQC N +C+ + CD +DC D SDE C C ++F C G
Sbjct: 162 GC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGA 220
Query: 3527 CVSSRFWCDGDFDCADGSDE------------RNCETSC-SKDQFRCSNGQCIPAKWKCD 3573
C+ R+ CD FDC D SDE + +C + QF C +G+C+ W+CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VT 3630
G DCK DE C TC E+ C C+ A CN E DC DGSDE C +
Sbjct: 281 GDRDCKDKSDEADCPLG--TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
Query: 3631 ECKEDQFRCKNKAHCIPIRWLC 3652
EC + C + + I + C
Sbjct: 339 ECLHNNGGCSHICTDLKIGFEC 360
Score = 184 bits (466), Expect = 2e-45
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 376 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 431
Query: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 432 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 487
Query: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 488 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 544
Query: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 545 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
Query: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
Query: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
Query: 818 CACADNQLLDENGTTC 833
CAC D L + C
Sbjct: 719 CACPDTMWLGPDMKRC 734
Score = 179 bits (454), Expect = 6e-44
Identities = 123/372 (33%), Positives = 159/372 (42%), Gaps = 64/372 (17%)
Query: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
+F+C N CI CD C D SDE C ++C C N CI CDGE
Sbjct: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWKCDGE 108
Query: 2575 NDCGDNSDELD--CKVSTCATVEFRCADGT--CIPRSARCNQNIDCADASDEKNCNNTDC 2630
+C D SDE + C C + C + C+P S RC+ DC +DE C
Sbjct: 109 EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCA 168
Query: 2631 THFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSC- 2689
H ++ G ++ C+ ++CDG +DCGD SDE C C F C
Sbjct: 169 PHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCA---DPACGPREFRCG 214
Query: 2690 --PSGRCILNTWICDGQKDCEDGRDE------------FHCDSSCSW-NQFACSAQKCIS 2734
G CI W+CD Q DCED DE ++C+ +QFAC + +C+
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
Query: 2735 KHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDEL 2794
W CDG+ DC D DE+D C TC D F C G CV C+ E+DCPDGSDE
Sbjct: 275 LGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE- 330
Query: 2795 STAGCAPN-NTCDENAFMCHNKVC----------------IPKQFVCDHDDDCGDGSDES 2837
AGC N C N C + +C + Q C D+C D S
Sbjct: 331 --AGCLQGLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACS 387
Query: 2838 PQC----GYRQC 2845
C GY +C
Sbjct: 388 QICVNYKGYFKC 399
Score = 172 bits (435), Expect = 9e-42
Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)
Query: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 443
Query: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
Query: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
Query: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 678 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 736
Score = 157 bits (396), Expect = 3e-37
Identities = 105/343 (30%), Positives = 146/343 (42%), Gaps = 40/343 (11%)
Query: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
Query: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
SDE C + C C + +C+P CDGE DC +DE C + CA EF
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-ATLCAPHEF 172
Query: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRC--NSTSLCVL 2654
+C + +C+ C+ + DC D SDE+ C + C G + RC + C+
Sbjct: 173 QCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC------GPRE---FRCGGDGGGACIP 223
Query: 2655 PTWICDGSNDCGDYSDELK--C------PVQNKHKC-EENYFSCPSGRCILNTWICDGQK 2705
W+CD DC D SDE C C + F+C SG C+ W CDG +
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 2706 DCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAAD 2764
DC+D DE C +C ++F C C+ C+ E DC DG DE+ + G C +
Sbjct: 284 DCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHN 343
Query: 2765 MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDE 2807
C S C E CP G L C + C +
Sbjct: 344 NGGC--SHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKD 382
Score = 155 bits (392), Expect = 9e-37
Identities = 112/367 (30%), Positives = 150/367 (40%), Gaps = 42/367 (11%)
Query: 3255 WHAITDIQVYHSYRQPDVSKHLCM-----INNGGCSHLCLLAPGKTHTCACPTNFYLAAD 3309
W D + D K C +NG C H G+ CP
Sbjct: 64 WRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE---CPDGS--DES 118
Query: 3310 NRTCLSN-CTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
TC C A + C + KC+P W+CD DC G+DE C C P FQCG
Sbjct: 119 EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG-CATL-CAPHEFQCGN 176
Query: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC--TKNQKCIPVNLRCNGQDDCGD 3424
C F+CDG++DCGD SDE C C +F+C CIP C+ Q DC D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 3425 EEDE------------RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD 3472
DE P + F C++ + C+ W CD D DC D SDEA+C
Sbjct: 237 RSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDEADCP 295
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
TC EFQC + C+ C+ + DC D SDE C L + L NG C
Sbjct: 296 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICT 352
Query: 3533 WCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCKYGEDE 3584
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 353 DLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
Query: 3585 KSCEPAS 3591
K+C+ A+
Sbjct: 412 KNCKAAA 418
Score = 146 bits (368), Expect = 5e-34
Identities = 73/187 (39%), Positives = 99/187 (52%), Gaps = 20/187 (10%)
Query: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN---RCIP 900
+C EF+C NR C+ A + CDGDDDC DGSDE C + +C +F+C + CIP
Sbjct: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGGACIP 223
Query: 901 KRWLCDGANDCGSNEDESNQTC----------TARTCQVDQFSCGNGRCIPRAWLCDRED 950
+RW+CD DC DE+ + C A QF+C +G C+ W CD +
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 951 DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCF 1007
DC D++DE A C TC +F C G C+ + HC+ + DC DGSDE GC ++ C
Sbjct: 284 DCKDKSDE-ADCPLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECL 341
Query: 1008 DNQFRCS 1014
N CS
Sbjct: 342 HNNGGCS 348
Score = 137 bits (344), Expect = 3e-31
Identities = 129/551 (23%), Positives = 214/551 (38%), Gaps = 107/551 (19%)
Query: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857
G P C+++ F C N+ CIP + CD DDDC D SDE C + C +F+C +G C
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
Query: 2858 LLNTQWQCDGDFDCPDHSDEA-----------------PLNPKCKSAEQSCNSS------ 2894
++ +W+CDG+ +CPD SDE+ P + KC A C+
Sbjct: 99 -IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 2895 -------------FFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQD 2941
F C N C+ + +CD DDCGDGSDER C C ++ C D
Sbjct: 158 ADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFR-CGGD 216
Query: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFPCSQQCINTYGTYKCLCTDGYEI- 2999
+ + C F +D ++ G + T + C + +
Sbjct: 217 GGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG 276
Query: 3000 -QPDNPNGCKSLSDEE-----------------PFLILADHHEIRKISTDGSNYTLLKQG 3041
+ D CK SDE ++ H + DGS+ QG
Sbjct: 277 WRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3042 LNNV-------------IAIDFDYREEFIYWIDSSRPNG--------SRINRMCLNGSDI 3080
LN + I F+ + + + G +++C+N
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN---Y 393
Query: 3081 KVVHNTAVPNALAVDWIGKN-----------LYWSDTEKRIIEVSKLNGLYPTILVSKRL 3129
K +D + KN ++ + E R I++ K N Y ++ L
Sbjct: 394 KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN--YSRLI--PML 449
Query: 3130 KFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTN----QSVVIETKISRPMALTIDYVN 3185
K L ++ +YW D Y I MD + Q V+I+ ++ P L +D+V+
Sbjct: 450 KNVVALDVEVATNRIYWCD-LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 3186 RRLYWADENH--IEFSNMDGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTKSLSRAH 3241
+ +YW D + I + +DG R + ++++ P IA+ ++YW+D ++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 3242 KTSGADRLSLI 3252
+G DR +L+
Sbjct: 569 GLNGVDRQTLV 579
Score = 136 bits (343), Expect = 4e-31
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
Query: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 445 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
Query: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 501 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
Query: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
Query: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
Query: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 679 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 135 bits (340), Expect = 9e-31
Identities = 70/170 (41%), Positives = 98/170 (57%), Gaps = 14/170 (8%)
Query: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
Query: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 94 -DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
Query: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
DCE +DE C + LC P + C N + CL +C+G DC DGSDE
Sbjct: 152 KDCEGGADEAGC-ATLCAPHEFQCGNRS--CLAAVFVCDGDDDCGDGSDE 198
Score = 124 bits (311), Expect = 2e-27
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 381 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 438
Query: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
S + P KNV+AL + TNRI++ D + I D
Sbjct: 439 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 486
Query: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 487 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 541
Query: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 542 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 599
Query: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 600 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 657
Query: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 658 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 715
Query: 2486 RVNCSC 2491
+ C+C
Sbjct: 716 KYTCAC 721
Score = 70.1 bits (170), Expect = 5e-11
Identities = 35/85 (41%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
Query: 86 GT-NKCVHLSQLCNGVLDCPDGYDE 109
T +KCV S C+G DC G DE
Sbjct: 136 PTSHKCVPASWRCDGEKDCEGGADE 160
Score = 69.3 bits (168), Expect = 8e-11
Identities = 50/153 (32%), Positives = 68/153 (44%), Gaps = 13/153 (8%)
Query: 5 LLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
LL LL L L A +G + C+ +F C + C+ W CD D DC D SDE
Sbjct: 20 LLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE 78
Query: 65 SLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQL 123
D CP++ C + C C+H C+G +CPDG DE C + + ++L
Sbjct: 79 --DDCPKKT---CADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 124 NC---QYKCTMVRNSTRCYCEDGFEITEDGRSC 153
+C +KC V S RC E E D C
Sbjct: 133 SCGPTSHKC--VPASWRCDGEKDCEGGADEAGC 163
Score = 64.3 bits (155), Expect = 3e-09
Identities = 51/168 (30%), Positives = 64/168 (38%), Gaps = 26/168 (15%)
Query: 2508 SSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPH 2567
++C S+F C +GEC+ CDG CKDKSDE C +CR C + C+
Sbjct: 257 AACATASQFACRSGECVHLGWRCDGDRDCKDKSDE--ADCPLGTCRGDEFQCGDGTCVLA 314
Query: 2568 GKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNN 2627
K C+ E DC D SDE C C+ + C+ C D C
Sbjct: 315 IKHCNQEQDCPDGSDEAGCLQGL----------NECLHNNGGCSH--ICTDLKIGFEC-- 360
Query: 2628 TDCTHFYKLGVKTTGFI-RCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
T F L KT G I C C S C +Y KC
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDAC---------SQICVNYKGYFKC 399
Score = 55.8 bits (133), Expect = 9e-07
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818
A+ C+KD+F C N++CIP +CD DDC D SDE C + TC D+ C D+ +C
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
Query: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
+ K C G + + C E L G SH+C V S++C
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
Score = 46.6 bits (109), Expect = 6e-04
Identities = 43/165 (26%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCP 104
CV SW CDG+ DC +DE+ C + C G C+ +C+G DC
Sbjct: 141 CVPASWRCDGEKDCEGGADEA------GCATLCAPHEFQC-GNRSCLAAVFVCDGDDDCG 193
Query: 105 DGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYG- 163
DG DE C + ++ C R C+ F+ + RS + + C G
Sbjct: 194 DGSDER-GCADPACGPREFRCGGDGGGACIPERWVCDRQFDC--EDRSDEAAELCGRPGP 250
Query: 164 --TCSQTCRNTHGSYTC---SCVEGYLMQPDNRSCKAKIEPTDRP 203
T + T + C CV +R CK K + D P
Sbjct: 251 GATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
Score = 39.7 bits (91), Expect = 0.070
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 390
Query: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 391 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 425
Score = 38.5 bits (88), Expect = 0.16
Identities = 26/66 (39%), Positives = 32/66 (48%), Gaps = 5/66 (7%)
Query: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KA 847
QG N C NNGGCS +C + G C C A QLLD+ G +A IC
Sbjct: 335 QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
Query: 848 GEFRCK 853
G F+C+
Sbjct: 395 GYFKCE 400
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 536 bits (1381), Expect = e-151
Identities = 274/708 (38%), Positives = 397/708 (56%), Gaps = 42/708 (5%)
Query: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
C DQF+C+N RCIP W CD +DC + DE + C +TC F+C NG CI W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 946 CDREDDCGDQTDEM-ASCEFPTCEPLTQFVC--KSGRCISSKWHCDSDDDCGDGSDEVGC 1002
CD E++C D +DE A+C C P + C S +C+ + W CD + DC G+DE GC
Sbjct: 105 CDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1003 VHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHP 1062
C ++F+C + C+ + CDGD+DCGD SDE C PA C EF+C
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCA-----DPA-CGPREFRCGG 215
Query: 1063 DGN--CVPDLWRCDGEKDCEDGSDEK---------GCNGTIRLCDHKTKFSCWSTGRCIN 1111
DG C+P+ W CD + DCED SDE G C ++F+C S G C++
Sbjct: 216 DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS-GECVH 274
Query: 1112 KAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE-G 1170
W CDGD DC+D+SDE DC C + C + T C+ K CN ++DCPDGSDE G
Sbjct: 275 LGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAG 332
Query: 1171 YL--CDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVC 1228
L +EC NNGGCS+ C+ + G C+CP G QL D KTC +D C + CSQ+C
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQIC 390
Query: 1229 EQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLR 1288
+K KC CY G+++D+ ++C + +IF+ RHE+RRIDL KR+YS L+P L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
Query: 1289 NTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN 1348
N +ALD + +YW D+ +IY + ++ EV+++ L +PEGL VDW+ +
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
Query: 1349 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408
IYW DS I VA +DG R TL + + PRAIA+DP G ++W+DW + +IE +
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSG 569
Query: 1409 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEY 1468
++G R+T+ D WPNG+T+D +R+ W D++ + S + G N +I ++
Sbjct: 570 LNGVDRQTLVSD--NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 1469 LSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAP 1528
LSHPF ++++ +V+WTD + AN+ G +S++ + P D+ I+H +QP+AP
Sbjct: 628 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
Query: 1529 NPCAAN-DGKGPCSHMCL-----INHNRSAACACPHLMKLSSDKKTCY 1570
+ C + G C ++CL +H+ CACP M L D K CY
Sbjct: 688 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
Score = 432 bits (1111), Expect = e-120
Identities = 246/697 (35%), Positives = 354/697 (50%), Gaps = 74/697 (10%)
Query: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICD 2740
CE++ F C + RCI + W CD DC D DE C +C+ + F C CI + W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2741 GEDDCGDGLDESDSICGAITCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
GE++C DG DES++ C C A+ SC S CVP W CDGE+DC G+DE AGC
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
Query: 2800 APNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCAD--GRC 2857
A C + F C N+ C+ FVCD DDDCGDGSDE C CG EF C G
Sbjct: 164 A--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGA 220
Query: 2858 LLNTQWQCDGDFDCPDHSDEAPL-----NPKCKSAEQSC-NSSFFMCKNGRCIPSGGLCD 2911
+ +W CD FDC D SDEA P SA +C +S F C++G C+ G CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 2912 NKDDCGDGSDERNCHI-----------------------------------------NEC 2930
DC D SDE +C + NEC
Sbjct: 281 GDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 340
Query: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
L GCS C DL + ++C C GFQL D KTC DIDEC CSQ C+N G +K
Sbjct: 341 LHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFK 398
Query: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
C C GYE+ N CK+ + + P LI + HE+R+I NY+ L L NV+A+D
Sbjct: 399 CECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
Query: 3051 DYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTE 3107
+ IYW D S R S + + +V+ + + P LAVDW+ K++YW+D+
Sbjct: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
Query: 3108 KRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSV 3167
+ I V+ ++G L S+ L PR +++DP G++YW D + I + G++G ++
Sbjct: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
Query: 3168 VIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALTLF 3223
++ I P +T+D +++RLYW D + S++D G+ + + + D + + +F
Sbjct: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
Query: 3224 EDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMINN 3281
ED ++WTD + +++ A++ +G + L + + DI ++H +QP + L + N
Sbjct: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
Query: 3282 GGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
GGC +LCL AP +TCACP +L D + C
Sbjct: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 372 bits (954), Expect = e-102
Identities = 229/723 (31%), Positives = 331/723 (45%), Gaps = 77/723 (10%)
Query: 3515 CTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC-ETSCSKDQFRCSNGQCIPAKWKCD 3573
C F C N C+ S + CD D DC D SDE +C + +C+ F C NG CI +WKCD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICA--SDGCISASLKCNGEYDCADGSDEMDCVTE 3631
G E+C G DE C + + C S C+ AS +C+GE DC G+DE C T
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Query: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNS---LCKL 3688
C +F+C N++ C+ ++CDG DC DGSDE C C EF C C
Sbjct: 167 CAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIP 223
Query: 3689 HFWVCDGEDDCGDNSDEAPDMCVK---------FLCPSTRPHRCRNNRICLQSEQMCNGI 3739
WVCD + DC D SDEA ++C + C + CR+ C+ C+G
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGD 282
Query: 3740 DECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIA 3799
+C D SDE C C+ DEF C + C+ C++ DC DGSDE GC
Sbjct: 283 RDCKDKSDEADC------PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3800 PTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCI 3859
E C N C C +K C C GFQ + + C D++EC CS C+
Sbjct: 337 LNE--CLHNNGGCSH--ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICV 391
Query: 3860 NVEGSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISH 3916
N +G +KC C ++ C A + L N ++ + NYS
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RL 445
Query: 3917 IEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRP 3971
I + +DV + I W + Y++I+ +A+ LI + P
Sbjct: 446 IPMLKNVVALDVEVATNRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSP 499
Query: 3972 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 4031
+AVDWV +IYWTD +I+V ++G L + EP A
Sbjct: 500 EGLAVDWVHKHIYWTDSGNK---------------TISVATVDGGRRRTLFSRNLSEPRA 544
Query: 4032 IAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFE 4091
IAV+P RG MYW+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +
Sbjct: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
Query: 4092 LSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEY 4150
L + S+ + G N +SS L HP I +FED ++ +N +F + +
Sbjct: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
Query: 4151 LALNIDKTKGVLISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEG 4199
LA N++ ++I H KQ P+ C + CE+LCL P + TC CP+
Sbjct: 665 LAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
Query: 4200 KYL 4202
+L
Sbjct: 725 MWL 727
Score = 248 bits (632), Expect = 1e-64
Identities = 134/343 (39%), Positives = 174/343 (50%), Gaps = 30/343 (8%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN---CI 3489
C+P FQC + C++ ++VCD D DC D SDE C CGP EF+C + CI
Sbjct: 164 ATLCAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
Query: 3490 PDHWRCDSQNDCSDNSDE--ENC---------KPQTC-TLKDFLCANGDCVSSRFWCDGD 3537
P+ W CD Q DC D SDE E C P C T F C +G+CV + CDGD
Sbjct: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGD 282
Query: 3538 FDCADGSDERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSS 3596
DC D SDE +C +C D+F+C +G C+ A C+ +DC G DE C C
Sbjct: 283 RDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 342
Query: 3597 REYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
C+ I LK E C G D+ C + ECK+
Sbjct: 343 NNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 382
Score = 237 bits (604), Expect = 2e-61
Identities = 160/494 (32%), Positives = 241/494 (48%), Gaps = 32/494 (6%)
Query: 36 EFLCHDHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIACLGTNKCVH 92
+F C CV W CDGD DC D SDE+ L TC + E +C G CV
Sbjct: 264 QFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD-EFQC--------GDGTCVL 313
Query: 93 LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDG 150
+ CN DCPDG DE C + L+ C N C + CT ++ C C GF++ D
Sbjct: 314 AIKHCNQEQDCPDGSDEA-GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQ 371
Query: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIAN 210
++C D DEC CSQ C N G + C C GY M ++CKA + P L+ N
Sbjct: 372 KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTN 428
Query: 211 FETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGL 270
+ L + L + N + LD + I W + S ++ + KA
Sbjct: 429 RHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD- 484
Query: 271 TDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKA 330
E + I + H+ + +A+DW+ +++Y+ D I V +G TL L P+A
Sbjct: 485 PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRA 544
Query: 331 IAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLY 390
IAVDP+ G ++++D+G+ AK+E+ ++G++R ++ E P + LDL+++ +YWVD
Sbjct: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
Query: 391 LDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHS 449
L + +D+ G NR T+I + H +GI VFED ++ T+ +N I NR NG +I
Sbjct: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
Query: 450 LIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCR 504
L + + N I I+ + QP ACE+ GGC ++CL +SS TC C
Sbjct: 665 LAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Query: 505 TGFNLGSDGRSCKR 518
LG D + C R
Sbjct: 723 DTMWLGPDMKRCYR 736
Score = 220 bits (561), Expect = 2e-56
Identities = 113/322 (35%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
Query: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3470 NCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLC---ANGD 3526
C C PHEFQC N +C+ + CD +DC D SDE C C ++F C G
Sbjct: 162 GC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGA 220
Query: 3527 CVSSRFWCDGDFDCADGSDE------------RNCETSC-SKDQFRCSNGQCIPAKWKCD 3573
C+ R+ CD FDC D SDE + +C + QF C +G+C+ W+CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VT 3630
G DCK DE C TC E+ C C+ A CN E DC DGSDE C +
Sbjct: 281 GDRDCKDKSDEADCPLG--TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
Query: 3631 ECKEDQFRCKNKAHCIPIRWLC 3652
EC + C + + I + C
Sbjct: 339 ECLHNNGGCSHICTDLKIGFEC 360
Score = 184 bits (466), Expect = 2e-45
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 376 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 431
Query: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 432 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 487
Query: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 488 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 544
Query: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 545 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
Query: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
Query: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
Query: 818 CACADNQLLDENGTTC 833
CAC D L + C
Sbjct: 719 CACPDTMWLGPDMKRC 734
Score = 179 bits (454), Expect = 6e-44
Identities = 123/372 (33%), Positives = 159/372 (42%), Gaps = 64/372 (17%)
Query: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
+F+C N CI CD C D SDE C ++C C N CI CDGE
Sbjct: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWKCDGE 108
Query: 2575 NDCGDNSDELD--CKVSTCATVEFRCADGT--CIPRSARCNQNIDCADASDEKNCNNTDC 2630
+C D SDE + C C + C + C+P S RC+ DC +DE C
Sbjct: 109 EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCA 168
Query: 2631 THFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSC- 2689
H ++ G ++ C+ ++CDG +DCGD SDE C C F C
Sbjct: 169 PHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCA---DPACGPREFRCG 214
Query: 2690 --PSGRCILNTWICDGQKDCEDGRDE------------FHCDSSCSW-NQFACSAQKCIS 2734
G CI W+CD Q DCED DE ++C+ +QFAC + +C+
Sbjct: 215 GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
Query: 2735 KHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDEL 2794
W CDG+ DC D DE+D C TC D F C G CV C+ E+DCPDGSDE
Sbjct: 275 LGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE- 330
Query: 2795 STAGCAPN-NTCDENAFMCHNKVC----------------IPKQFVCDHDDDCGDGSDES 2837
AGC N C N C + +C + Q C D+C D S
Sbjct: 331 --AGCLQGLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACS 387
Query: 2838 PQC----GYRQC 2845
C GY +C
Sbjct: 388 QICVNYKGYFKC 399
Score = 172 bits (435), Expect = 9e-42
Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)
Query: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 443
Query: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
Query: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
Query: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 678 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 736
Score = 157 bits (396), Expect = 3e-37
Identities = 105/343 (30%), Positives = 146/343 (42%), Gaps = 40/343 (11%)
Query: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
Query: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
SDE C + C C + +C+P CDGE DC +DE C + CA EF
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-ATLCAPHEF 172
Query: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRC--NSTSLCVL 2654
+C + +C+ C+ + DC D SDE+ C + C G + RC + C+
Sbjct: 173 QCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC------GPRE---FRCGGDGGGACIP 223
Query: 2655 PTWICDGSNDCGDYSDELK--C------PVQNKHKC-EENYFSCPSGRCILNTWICDGQK 2705
W+CD DC D SDE C C + F+C SG C+ W CDG +
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 2706 DCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAAD 2764
DC+D DE C +C ++F C C+ C+ E DC DG DE+ + G C +
Sbjct: 284 DCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHN 343
Query: 2765 MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDE 2807
C S C E CP G L C + C +
Sbjct: 344 NGGC--SHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKD 382
Score = 155 bits (392), Expect = 9e-37
Identities = 112/367 (30%), Positives = 150/367 (40%), Gaps = 42/367 (11%)
Query: 3255 WHAITDIQVYHSYRQPDVSKHLCM-----INNGGCSHLCLLAPGKTHTCACPTNFYLAAD 3309
W D + D K C +NG C H G+ CP
Sbjct: 64 WRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE---CPDGS--DES 118
Query: 3310 NRTCLSN-CTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
TC C A + C + KC+P W+CD DC G+DE C C P FQCG
Sbjct: 119 EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG-CATL-CAPHEFQCGN 176
Query: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC--TKNQKCIPVNLRCNGQDDCGD 3424
C F+CDG++DCGD SDE C C +F+C CIP C+ Q DC D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 3425 EEDE------------RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD 3472
DE P + F C++ + C+ W CD D DC D SDEA+C
Sbjct: 237 RSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDEADCP 295
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
TC EFQC + C+ C+ + DC D SDE C L + L NG C
Sbjct: 296 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICT 352
Query: 3533 WCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCKYGEDE 3584
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 353 DLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
Query: 3585 KSCEPAS 3591
K+C+ A+
Sbjct: 412 KNCKAAA 418
Score = 146 bits (368), Expect = 5e-34
Identities = 73/187 (39%), Positives = 99/187 (52%), Gaps = 20/187 (10%)
Query: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN---RCIP 900
+C EF+C NR C+ A + CDGDDDC DGSDE C + +C +F+C + CIP
Sbjct: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGGACIP 223
Query: 901 KRWLCDGANDCGSNEDESNQTC----------TARTCQVDQFSCGNGRCIPRAWLCDRED 950
+RW+CD DC DE+ + C A QF+C +G C+ W CD +
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 951 DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCF 1007
DC D++DE A C TC +F C G C+ + HC+ + DC DGSDE GC ++ C
Sbjct: 284 DCKDKSDE-ADCPLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECL 341
Query: 1008 DNQFRCS 1014
N CS
Sbjct: 342 HNNGGCS 348
Score = 137 bits (344), Expect = 3e-31
Identities = 129/551 (23%), Positives = 214/551 (38%), Gaps = 107/551 (19%)
Query: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857
G P C+++ F C N+ CIP + CD DDDC D SDE C + C +F+C +G C
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
Query: 2858 LLNTQWQCDGDFDCPDHSDEA-----------------PLNPKCKSAEQSCNSS------ 2894
++ +W+CDG+ +CPD SDE+ P + KC A C+
Sbjct: 99 -IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 2895 -------------FFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQD 2941
F C N C+ + +CD DDCGDGSDER C C ++ C D
Sbjct: 158 ADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFR-CGGD 216
Query: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFPCSQQCINTYGTYKCLCTDGYEI- 2999
+ + C F +D ++ G + T + C + +
Sbjct: 217 GGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG 276
Query: 3000 -QPDNPNGCKSLSDEE-----------------PFLILADHHEIRKISTDGSNYTLLKQG 3041
+ D CK SDE ++ H + DGS+ QG
Sbjct: 277 WRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3042 LNNV-------------IAIDFDYREEFIYWIDSSRPNG--------SRINRMCLNGSDI 3080
LN + I F+ + + + G +++C+N
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN---Y 393
Query: 3081 KVVHNTAVPNALAVDWIGKN-----------LYWSDTEKRIIEVSKLNGLYPTILVSKRL 3129
K +D + KN ++ + E R I++ K N Y ++ L
Sbjct: 394 KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN--YSRLI--PML 449
Query: 3130 KFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTN----QSVVIETKISRPMALTIDYVN 3185
K L ++ +YW D Y I MD + Q V+I+ ++ P L +D+V+
Sbjct: 450 KNVVALDVEVATNRIYWCD-LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH 508
Query: 3186 RRLYWADENH--IEFSNMDGSHRHKVPNQDI--PGVIALTLFEDYIYWTDGKTKSLSRAH 3241
+ +YW D + I + +DG R + ++++ P IA+ ++YW+D ++
Sbjct: 509 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 568
Query: 3242 KTSGADRLSLI 3252
+G DR +L+
Sbjct: 569 GLNGVDRQTLV 579
Score = 136 bits (343), Expect = 4e-31
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
Query: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 445 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
Query: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 501 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
Query: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
Query: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
Query: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 679 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 135 bits (340), Expect = 9e-31
Identities = 70/170 (41%), Positives = 98/170 (57%), Gaps = 14/170 (8%)
Query: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
Query: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 94 -DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
Query: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
DCE +DE C + LC P + C N + CL +C+G DC DGSDE
Sbjct: 152 KDCEGGADEAGC-ATLCAPHEFQCGNRS--CLAAVFVCDGDDDCGDGSDE 198
Score = 124 bits (311), Expect = 2e-27
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 381 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 438
Query: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
S + P KNV+AL + TNRI++ D + I D
Sbjct: 439 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 486
Query: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 487 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 541
Query: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 542 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 599
Query: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 600 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 657
Query: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 658 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 715
Query: 2486 RVNCSC 2491
+ C+C
Sbjct: 716 KYTCAC 721
Score = 70.1 bits (170), Expect = 5e-11
Identities = 35/85 (41%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
Query: 86 GT-NKCVHLSQLCNGVLDCPDGYDE 109
T +KCV S C+G DC G DE
Sbjct: 136 PTSHKCVPASWRCDGEKDCEGGADE 160
Score = 69.3 bits (168), Expect = 8e-11
Identities = 50/153 (32%), Positives = 68/153 (44%), Gaps = 13/153 (8%)
Query: 5 LLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
LL LL L L A +G + C+ +F C + C+ W CD D DC D SDE
Sbjct: 20 LLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE 78
Query: 65 SLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQL 123
D CP++ C + C C+H C+G +CPDG DE C + + ++L
Sbjct: 79 --DDCPKKT---CADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 124 NC---QYKCTMVRNSTRCYCEDGFEITEDGRSC 153
+C +KC V S RC E E D C
Sbjct: 133 SCGPTSHKC--VPASWRCDGEKDCEGGADEAGC 163
Score = 64.3 bits (155), Expect = 3e-09
Identities = 51/168 (30%), Positives = 64/168 (38%), Gaps = 26/168 (15%)
Query: 2508 SSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPH 2567
++C S+F C +GEC+ CDG CKDKSDE C +CR C + C+
Sbjct: 257 AACATASQFACRSGECVHLGWRCDGDRDCKDKSDE--ADCPLGTCRGDEFQCGDGTCVLA 314
Query: 2568 GKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNN 2627
K C+ E DC D SDE C C+ + C+ C D C
Sbjct: 315 IKHCNQEQDCPDGSDEAGCLQGL----------NECLHNNGGCSH--ICTDLKIGFEC-- 360
Query: 2628 TDCTHFYKLGVKTTGFI-RCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
T F L KT G I C C S C +Y KC
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDAC---------SQICVNYKGYFKC 399
Score = 55.8 bits (133), Expect = 9e-07
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818
A+ C+KD+F C N++CIP +CD DDC D SDE C + TC D+ C D+ +C
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
Query: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
+ K C G + + C E L G SH+C V S++C
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
Score = 46.6 bits (109), Expect = 6e-04
Identities = 43/165 (26%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCP 104
CV SW CDG+ DC +DE+ C + C G C+ +C+G DC
Sbjct: 141 CVPASWRCDGEKDCEGGADEA------GCATLCAPHEFQC-GNRSCLAAVFVCDGDDDCG 193
Query: 105 DGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYG- 163
DG DE C + ++ C R C+ F+ + RS + + C G
Sbjct: 194 DGSDER-GCADPACGPREFRCGGDGGGACIPERWVCDRQFDC--EDRSDEAAELCGRPGP 250
Query: 164 --TCSQTCRNTHGSYTC---SCVEGYLMQPDNRSCKAKIEPTDRP 203
T + T + C CV +R CK K + D P
Sbjct: 251 GATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
Score = 39.7 bits (91), Expect = 0.070
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 390
Query: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 391 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 425
Score = 38.5 bits (88), Expect = 0.16
Identities = 26/66 (39%), Positives = 32/66 (48%), Gaps = 5/66 (7%)
Query: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KA 847
QG N C NNGGCS +C + G C C A QLLD+ G +A IC
Sbjct: 335 QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
Query: 848 GEFRCK 853
G F+C+
Sbjct: 395 GYFKCE 400
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 520 bits (1339), Expect = e-146
Identities = 280/760 (36%), Positives = 407/760 (53%), Gaps = 38/760 (5%)
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
C+ +F+C N CI WKCDGD+DC+DGSDE NC +C + F C N +C+P RW
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTCAESDFVCNNGQCVPSRWK 90
Query: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
CDG DC DES + C RTC++ + SCG + +CIP +W CD E+DC DE +C
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
Query: 963 EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-SCFDNQFRCSSGRCIPG 1021
TC P +F C SGRCIS + C+ DDC DGSDE+ C +C ++F+CS+ CIP
Sbjct: 150 GNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
Query: 1022 HWACDGDNDCGDFSDEAQINCTKEE-IHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
W CD D DC D SDE+ C ++ IH+ C +E QC G C+ WRCDG+ DC+
Sbjct: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTK--CPASEIQCG-SGECIHKKWRCDGDPDCK 265
Query: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSF--LCGP 1138
DGSDE C R C +F C G CI+ + C+G DC D SDE +C + GP
Sbjct: 266 DGSDEVNCPS--RTC-RPDQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 1139 PKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYL---CDECSLNNGGCSNHCSVVPGRGI 1195
K C + C+ K+CN ++DC D SDE +EC +NNGGCS+ C + G
Sbjct: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
Query: 1196 VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSV 1255
C C G +L D KTC +D C N CSQ+C K KC C G+++D+ C +V
Sbjct: 379 ECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 1256 DPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRG 1315
E +IF+ R +IR+I L +++Y LV LRNT+ALD L+W D+ + I+
Sbjct: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
Query: 1316 KLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAG 1375
+ + G V + + P + VDW+ IYW D+ I VA LDG+ R L
Sbjct: 497 SIDDKVGR---HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
Query: 1376 AMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGAWPNGLTVDH 1434
+ P +IA+DP G ++W+DW +IE A M+G R+ + D++ WPNG+T+D
Sbjct: 554 DLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQ---WPNGITLDL 609
Query: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494
+ R+ W D++ + S +G + +++ E+L+HP A++++ VYW D +
Sbjct: 610 IKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
Query: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCL----IN-HN 1549
ANK+TG ++ + D+ +YH QP N C + G C ++CL IN H+
Sbjct: 670 ANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHS 729
Query: 1550 RSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDI 1589
C+CP + + + C + Y+ + +I
Sbjct: 730 PKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEI 769
Score = 502 bits (1293), Expect = e-141
Identities = 282/748 (37%), Positives = 407/748 (54%), Gaps = 46/748 (6%)
Query: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650
C +F+C +G CI +C+ + DC D SDEKNC C + F+ CN+
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAE--------SDFV-CNNGQ 83
Query: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQ-NKHKCEENYFSCP--SGRCILNTWICDGQKDC 2707
CV W CDG DC D SDE P Q + C + SC S +CI +W CDG+ DC
Sbjct: 84 -CVPSRWKCDGDPDCEDGSDE--SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
Query: 2708 EDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
+ G DE +C + +CS ++F CS+ +CIS++++C+G+DDC DG DE D C TC A F
Sbjct: 141 DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEF 198
Query: 2767 SCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP--NNTCDENAFMCHNKVCIPKQFV 2823
C S +C+P W+CD + DC D SDE L G P + C + C + CI K++
Sbjct: 199 QCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWR 257
Query: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883
CD D DC DGSDE C R C ++F C DG C+ ++ QC+G DC D SDE
Sbjct: 258 CDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----N 311
Query: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCSQD 2941
CK+ Q F C++G CI +C+ + DC D SDE + CHINECL GCS
Sbjct: 312 CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHI 370
Query: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP 3001
C+DL + Y+C C GF+L D KTC DIDEC + CSQ CIN G YKC C+ GY++
Sbjct: 371 CKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM-- 427
Query: 3002 DNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWID 3061
D G +EP LI + +IRKI + Y L + L N +A+D D + ++W D
Sbjct: 428 DLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
Query: 3062 SSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP 3121
S+ + G +K++ N P A+AVDW+ K +YW+D + I V+ L+G
Sbjct: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Query: 3122 TILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTI 3181
L + L+ P +++DP +G++YW D E I + GM+G ++ ++ I P +T+
Sbjct: 548 KFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
Query: 3182 DYVNRRLYWADENHIEFSNMD--GSHRHKVPN--QDIPGVIALTLFEDYIYWTDGKTKSL 3237
D + RLYW D S++D G R V + + +ALT+FED +YW DG+ +++
Sbjct: 608 DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
Query: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCM--INNGGCSHLCLLAP--- 3292
A+K +G++ +L+ + + DI VYH QP K+ C + NGGC +LCL AP
Sbjct: 668 YGANKFTGSELATLVNNLNDAQDIIVYHELVQPS-GKNWCEEDMENGGCEYLCLPAPQIN 726
Query: 3293 --GKTHTCACPTNFYLAADNRTCLSNCT 3318
+TC+CP+ + + + R C S T
Sbjct: 727 DHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Score = 419 bits (1076), Expect = e-116
Identities = 266/760 (35%), Positives = 364/760 (47%), Gaps = 83/760 (10%)
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
K C P +FQC N CI W+CD DC D SDE+NC +TC DF+C NG CV SR+
Sbjct: 30 KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRW 89
Query: 3533 WCDGDFDCADGSDE--RNCE-TSCSKDQFRCS--NGQCIPAKWKCDGHEDCKYGEDEKSC 3587
CDGD DC DGSDE C +C + C + QCIP W+CDG DC GEDE++C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3588 EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV-TECKEDQFRCKNKAHCI 3646
+ TCS E+ C+S CIS + CNG+ DC+DGSDE+DC C +F+C + CI
Sbjct: 150 --GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CI 206
Query: 3647 PIRWLCDGIHDCVDGSDE--ENCERGGNI---CRADEFLCNNSLCKLHFWVCDGEDDCGD 3701
PI W+CD DC D SDE E C R I C A E C + C W CDG+ DC D
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
Query: 3702 NSDEAPDMCVKFLCPS--TRPHR--CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTY 3757
SDE CPS RP + C + C+ + CNGI +C D SDE +C
Sbjct: 267 GSDEVN-------CPSRTCRPDQFECEDGS-CIHGSRQCNGIRDCVDGSDEVNC-----K 313
Query: 3758 KARPC-KKDEFACSNKKCIPMDLQCDRLDDCGDGSDE--QGCRIAPTEYTCEDNVNPCGD 3814
C +F C + +CI + C++ DC D SDE + C I E VN G
Sbjct: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHIN------ECLVNNGGC 367
Query: 3815 DAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQ 3874
C + C C GF+ + + C D++EC G CS CIN++G YKC C + +Q
Sbjct: 368 SHICKDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQ 426
Query: 3875 E--RNNTCIAEGSEDQVLYIANDTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDVYY 3930
C A G E +++ N DI +G + I +E +D
Sbjct: 427 MDLATGVCKAVGKEPSLIF-TNRRDIRKIGL-------ERKEYIQLVEQLRNTVALDADI 478
Query: 3931 QRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSR 3990
+ W+ + IF I + R + P IAVDWV IYWTD
Sbjct: 479 AAQKLFWA-DLSQKAIFSASIDDKVGRHVK---MIDNVYNPAAIAVDWVYKTIYWTD--- 531
Query: 3991 MHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHS 4050
+ +I+V L+G L + EP +IAV+P G +YW+ G+ +
Sbjct: 532 ------------AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPA 579
Query: 4051 HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVS 4110
IE+A M+G RR LV ++Q P G+ +D R+YW D +L ++ SV +G + + +
Sbjct: 580 KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 4111 SKQGLLHPHRIDIFEDYIYGA-GPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQ 4169
S + L HP + IFED +Y G V+ KF + L N++ + +++ H Q
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQ 699
Query: 4170 LDLPNPCLD----LACEFLCLLNPS------GATCVCPEG 4199
N C + CE+LCL P TC CP G
Sbjct: 700 PSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSG 739
Score = 291 bits (746), Expect = 8e-78
Identities = 145/353 (41%), Positives = 193/353 (54%), Gaps = 16/353 (4%)
Query: 3315 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374
+ C SQF+C +CI WKCD +DC DGSDE +C + C F C G C +
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRW 89
Query: 3375 ICDGENDCGDNSDEL--NCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
CDG+ DC D SDE C C + C + +CIPV+ RC+G++DC EDE +C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
+CSPD F C + + CIS+ +VC+ DC+D SDE +C TCG HEFQC ++CIP
Sbjct: 150 GNITCSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
Query: 3492 HWRCDSQNDCSDNSDE--ENCKPQ-----TCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
W CD DCSD SDE E C Q C + C +G+C+ ++ CDGD DC DGS
Sbjct: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 268
Query: 3545 DERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 3603
DE NC + +C DQF C +G CI +C+G DC G DE +C+ + ++ C S
Sbjct: 269 DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 3604 DGCISASLKCNGEYDCADGSDE--MDC-VTECKEDQFRCKNKAHCIPIRWLCD 3653
CI S CN E DC D SDE +C + EC + C + + I + CD
Sbjct: 329 GECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
Score = 269 bits (687), Expect = 5e-71
Identities = 136/345 (39%), Positives = 177/345 (51%), Gaps = 23/345 (6%)
Query: 3356 RCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLR 3415
+C+P +FQC G C + CDG+ DC D SDE NC C F C Q C+P +
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWK 90
Query: 3416 CNGQDDCGDEEDE--RDCPENSCSPDYFQCKT-TKHCISKLWVCDEDPDCADASDEANCD 3472
C+G DC D DE C +C C + CI W CD + DC DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
TC P EF C + CI ++ C+ Q+DCSD SDE +C P TC +F C+ C+ +
Sbjct: 151 NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
Query: 3533 WCDGDFDCADGSDE--RNC------ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 3584
CD D DC+D SDE C T C + +C +G+CI KW+CDG DCK G DE
Sbjct: 211 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Query: 3585 KSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC--VTEC-KEDQFRCKN 3641
+C S TC ++ C CI S +CNG DC DGSDE++C V +C +F+C++
Sbjct: 271 VNC--PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 3642 KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLC 3686
CI I +C+ DC D SDE E C +E L NN C
Sbjct: 329 -GECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLVNNGGC 367
Score = 224 bits (571), Expect = 2e-57
Identities = 149/535 (27%), Positives = 243/535 (45%), Gaps = 72/535 (13%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C E C C+ + W CDGDPDC D SDE CP C + C C+
Sbjct: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEV--NCPSRT---CRPDQFEC-EDGSCI 291
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQEL----------------------------------- 116
H S+ CNG+ DC DG DE V+C+ +
Sbjct: 292 HGSRQCNGIRDCVDGSDE-VNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Query: 117 ------LSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQT 168
++ C N C + C + C C GFE+ D ++C D DEC G CSQ
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQI 409
Query: 169 CRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLS 228
C N G Y C C GY M CKA + P L+ N I L + L
Sbjct: 410 CINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIFTNRRDIRKIGLERKEYIQLV 465
Query: 229 SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQM 288
N + LD + W + + + I K G + ++ + +N +
Sbjct: 466 EQLRNTV-ALDADIAAQKLFWADLSQKAIFSASID-DKVGR-----HVKMIDNVYNPAAI 518
Query: 289 AIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNV 348
A+DW+ + +Y+ D I V +G+ L + +L P +IAVDP++G ++++D+G
Sbjct: 519 AVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEP 578
Query: 349 AKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVI 408
AK+E+ M+G +R ++ + + P + LDL+ +YW+D L + VD G++R V+
Sbjct: 579 AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVL 638
Query: 409 QGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRT 466
+ + + H +T+FED +Y + +N + N+F G+++ +L+ + +A I +Y +
Sbjct: 639 KSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 467 QPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRSCK 517
QP+ ++ CE D GGC ++CL ++ TC C +G+N+ +GR C+
Sbjct: 699 QPSGKNW-CEEDMEN--GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
Score = 216 bits (549), Expect = 5e-55
Identities = 141/391 (36%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 2463 CELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGE 2522
CE S NG C L L +G +C D + CV K A S+F C NG+
Sbjct: 33 CEPSQFQCTNGRCITL-LWKCDGDEDCVDGSD-----EKNCVKKTC---AESDFVCNNGQ 83
Query: 2523 CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDN 2580
C+ + CDG P C+D SDE C R+CR C ++ +CIP CDGENDC
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
Query: 2581 SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDC-THFYKLGVK 2639
DE +C TC+ EF C+ G CI R+ CN DC+D SDE +C C H ++
Sbjct: 144 EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC--- 200
Query: 2640 TTGFIRCNSTSLCVLPTWICDGSNDCGDYSDEL--KCPVQN--KHKCEENYFSCPSGRCI 2695
STS C+ +W+CD DC D SDE +C Q KC + C SG CI
Sbjct: 201 --------STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
Query: 2696 LNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDS 2754
W CDG DC+DG DE +C S +C +QF C CI C+G DC DG DE +
Sbjct: 253 HKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Query: 2755 ICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
F C+ S C+ +C+ E+DC D SDE P C N + +N
Sbjct: 313 KNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDE-------PLKECHINECLVNN 364
Query: 2815 KVC--IPKQFVCDHDDDCGDGSD--ESPQCG 2841
C I K V ++ DC G + + CG
Sbjct: 365 GGCSHICKDLVIGYECDCAAGFELIDRKTCG 395
Score = 196 bits (498), Expect = 4e-49
Identities = 111/323 (34%), Positives = 156/323 (48%), Gaps = 30/323 (9%)
Query: 3314 LSNCTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCAL 3371
+ C + C + +CIP W+CD +DC G DE ++C C P F C +G C
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENCGNITCSPDEFTCSSGRCIS 168
Query: 3372 PAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE--- 3428
F+C+G++DC D SDEL+C C + +F+C+ CIP++ C+ DC D+ DE
Sbjct: 169 RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLE 227
Query: 3429 ----RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCK 3484
+ C QC + + CI K W CD DPDC D SDE NC +TC P +F+C+
Sbjct: 228 QCGRQPVIHTKCPASEIQCGSGE-CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
Query: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCK--PQTCTLKDFLCANGDCVSSRFWCDGDFDCAD 3542
+ +CI +C+ DC D SDE NCK Q F C +G+C+ C+ + DC D
Sbjct: 287 DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
Query: 3543 GSDERNCETSCSKDQFRCSNGQCIP-AKWKCDGHE-DCKYG---EDEKSCEPASPTCSSR 3597
SDE E C ++ +NG C K G+E DC G D K+C
Sbjct: 347 WSDEPLKE--CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDE----- 399
Query: 3598 EYICASDG-CISASLKCNGEYDC 3619
C + G C + G Y C
Sbjct: 400 ---CQNPGICSQICINLKGGYKC 419
Score = 181 bits (459), Expect = 1e-44
Identities = 126/371 (33%), Positives = 180/371 (48%), Gaps = 30/371 (8%)
Query: 476 EVDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGI 534
++D PG CS IC+ L YK C C G+ + CK E L + R
Sbjct: 396 DIDECQNPGICSQICINLKGGYK---CECSRGYQMDLATGVCKAVGKEPSLIFTNRRD-- 450
Query: 535 VRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETI 593
+R + L K EY+ +E L N ALD +++AD + I ID R
Sbjct: 451 IRKIGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
Query: 594 LKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVD 653
+ D++ N IAVDW+ +YWT D KTI+VA L+ RK L ++ P I VD
Sbjct: 508 MIDNVYNPAAIAVDWVYKTIYWT-DAASKTISVATLD--GTKRKFLFNSDLREPASIAVD 564
Query: 654 PVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCD 713
P++G++YW+DW E +IEKA M+GF+R+ VT+ + WPNG+TLD + LYW D
Sbjct: 565 PLSGFVYWSDWGEP------AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLD 618
Query: 714 AYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEV 771
+ + V LNG R+IV E L HP L+ + V+W D N +++ + T SE+
Sbjct: 619 SKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEL 678
Query: 772 TLLRHERPPLFGLQIYDPRKQ-QGDNMCR--VNNGGCSTLCLAIP------GGRVCACAD 822
L + + +Y Q G N C + NGGC LCL P C+C
Sbjct: 679 ATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPS 738
Query: 823 NQLLDENGTTC 833
++ENG C
Sbjct: 739 GYNVEENGRDC 749
Score = 162 bits (410), Expect = 7e-39
Identities = 118/421 (28%), Positives = 196/421 (46%), Gaps = 28/421 (6%)
Query: 1792 WADQNLAQ--LGTCSKRDGRNPTILRNKTSG-----VVHMKVYDKEAQQGSNSCQLNNGG 1844
W+D+ L + + C +G I ++ G ++ D++ + CQ N G
Sbjct: 347 WSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGI 405
Query: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI--ESFLMYSVHEGIRGIPLEPSDKMDA 1902
CSQ+C+ + C C+ GY + C+ + E L+++ IR I LE + +
Sbjct: 406 CSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL 464
Query: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI-ITNGLGRVEGIAVD 1961
+ + T V +D ++W D+ I A D + + + + IAVD
Sbjct: 465 VEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021
W+ IYWTD I VA L+G+ R + + L +P SIAV P G ++W++WG+ I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081
KA ++G ++ LV+ I WPNGI++D +++LYW D++ + +DL G +R +VL
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRIVLKS 640
Query: 2082 SN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRV 2139
++ +F +YW D N +V +K +E T+ L + V
Sbjct: 641 LEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 2140 REKGTNVCARD--NGGCKQLCL-----YRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLY 2191
+ G N C D NGGC+ LCL + + TC+C GY + E+G C + Y
Sbjct: 699 QPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTY 758
Query: 2192 S 2192
S
Sbjct: 759 S 759
Score = 145 bits (366), Expect = 9e-34
Identities = 73/175 (41%), Positives = 100/175 (57%), Gaps = 13/175 (7%)
Query: 996 GSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNG 1055
G+ G C +QF+C++GRCI W CDGD DC D SDE NC K+ C
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKT------CAE 74
Query: 1056 NEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCD-HKTKFSCWSTGRCINKAW 1114
++F C+ +G CVP W+CDG+ DCEDGSDE +R C H+ ST +CI +W
Sbjct: 75 SDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHST-QCIPVSW 132
Query: 1115 VCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
CDG+ DC+ DE++C + C P + C++ C+ +CNG+ DC DGSDE
Sbjct: 133 RCDGENDCDSGEDEENCGNITCSPDEFTCSSGR--CISRNFVCNGQDDCSDGSDE 185
Score = 136 bits (343), Expect = 4e-31
Identities = 94/363 (25%), Positives = 171/363 (47%), Gaps = 23/363 (6%)
Query: 1538 GPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFN 1595
G CS +C IN C C ++ C + K L++ R +IR + ++ +
Sbjct: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 1596 FITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING-TGLETVISRDIQSIRGL 1654
+ V + + +D D + ++L+W D+ + I A I+ G + ++ + +
Sbjct: 463 QL----VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1655 AVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLYWTDGN 1713
AVDWV + +YW + I+VA LDG+ + + + + +P +A P+ G +YW+D
Sbjct: 519 AVDWVYKTIYWTDAA--SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
Query: 1714 T---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEV 1769
I A M+G + + L + P G+++D ++++LYW+ S ++ +L+G + +
Sbjct: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
Query: 1770 IESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDK 1829
+ E L ALTI + +++W D + +K G L N + + VY +
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
Query: 1830 EAQ-QGSNSCQ--LNNGGCSQLCLPTSETT-----RTCMCTVGYYLQKNRMSCQGIESFL 1881
Q G N C+ + NGGC LCLP + TC C GY +++N CQ + +
Sbjct: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTV 756
Query: 1882 MYS 1884
YS
Sbjct: 757 TYS 759
Score = 135 bits (340), Expect = 9e-31
Identities = 69/185 (37%), Positives = 91/185 (49%), Gaps = 9/185 (4%)
Query: 839 EALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC-----FNHSCPDDQFKC 893
+ P C A EF+C CI W CD D DC D SDE C + CP + +C
Sbjct: 187 DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC 246
Query: 894 QNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCG 953
+ CI K+W CDG DC DE N C +RTC+ DQF C +G CI + C+ DC
Sbjct: 247 GSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
Query: 954 DQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRC 1013
D +DE+ C +F C+SG CI C+ + DC D SDE + C N+
Sbjct: 305 DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEP--LKECHINECLV 362
Query: 1014 SSGRC 1018
++G C
Sbjct: 363 NNGGC 367
Score = 110 bits (275), Expect = 3e-23
Identities = 90/380 (23%), Positives = 170/380 (44%), Gaps = 39/380 (10%)
Query: 2152 GGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNL 2208
G C Q+C+ + C C+ GY LA + E L+++ R ++ I L + +
Sbjct: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 2209 NSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI--QLIKDNWEDRQVIVE 2266
+ +N +AL D ++F++D I I D +++
Sbjct: 463 -------QLVEQLRNTVALDADI-----AAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
Query: 2267 NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALD 2326
NV + +A + T+YWT + + +I+ T+D T+ + S+ P +A+D
Sbjct: 511 NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIAVD 564
Query: 2327 ECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGK 2386
++W++W E I ++ + G + + +V+ DI PNG+T+D +LY+ D L
Sbjct: 565 PLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
Query: 2387 IERCEYDGSQRHVIVKSGP--GTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRS 2444
+ + +G R +++KS L+L ++++ ++W D A+ +NK+TG + L +
Sbjct: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN 683
Query: 2445 DIPHQPMGII----AVANDTNSCELSPCALLNGGCHDLCLLTP-----NGRVNCSCRGDR 2495
++ I+ + N CE + NGGC LCL P + + CSC
Sbjct: 684 NLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
Query: 2496 ILLEDNRCVTKNSSCNAYSE 2515
+ E+ R ++ YSE
Sbjct: 741 NVEENGRDCQSTATTVTYSE 760
Score = 108 bits (270), Expect = 1e-22
Identities = 80/270 (29%), Positives = 113/270 (41%), Gaps = 69/270 (25%)
Query: 2793 ELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC 2852
E G C+ + F C N CI + CD D+DC DGSDE C + C +F C
Sbjct: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC 79
Query: 2853 ADGRCLLNTQWQCDGDFDCPDHSDEAPL------------------------------NP 2882
+G+C + ++W+CDGD DC D SDE+P
Sbjct: 80 NNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGEN 138
Query: 2883 KCKSAEQ-------SCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKV 2935
C S E +C+ F C +GRCI +C+ +DDC DGSDE +C C + +
Sbjct: 139 DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEF 198
Query: 2936 SGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD-----IDECS------SGFPCSQ-QCI 2983
+ C +P+S+ C DD C D +++C + P S+ QC
Sbjct: 199 QCSTSSC--IPISWVC---------DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 2984 NTYGTYKCLCTDGYEIQPDNPNGCKSLSDE 3013
+ +K DG PD CK SDE
Sbjct: 248 SGECIHKKWRCDG---DPD----CKDGSDE 270
Score = 73.9 bits (180), Expect = 3e-12
Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 27/186 (14%)
Query: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIAC-LGT 87
++ C +F+C++ CV W CDGDPDC D SDES + C C ++ I+C +
Sbjct: 69 KKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHS 124
Query: 88 NKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDGF 144
+C+ +S C+G DC G DE NC + C ++ C+ R +R + +G
Sbjct: 125 TQCIPVSWRCDGENDCDSGEDE--------ENCGNITCSPDEFTCSSGRCISRNFVCNGQ 176
Query: 145 EITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCK----AKIEPT 200
+ DG D+ +CA TC + T SC+ + D+ C +E
Sbjct: 177 DDCSDG---SDELDCAP-PTCG---AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC 229
Query: 201 DRPPIL 206
R P++
Sbjct: 230 GRQPVI 235
Score = 60.8 bits (146), Expect = 3e-08
Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C+P +F C + C++ W CDGD DC D SDE C V+ C + C +CV
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEK--NC---VKKTCAESDFVC-NNGQCV 85
Query: 92 HLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQLNCQYKCTM-VRNSTRCYCEDGFEITED 149
C+G DC DG DE C +++C T + S RC E+ + ED
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 150 GRSC 153
+C
Sbjct: 146 EENC 149
Score = 48.9 bits (115), Expect = 1e-04
Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 36/144 (25%)
Query: 3752 GGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP 3811
G T + C+ +F C+N +CI + +CD +DC DGSDE+ C + TC ++
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC----VKKTCAES--- 75
Query: 3812 CGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCED----------LNECLVF----GTCSHQ 3857
D CN +C P + + CED + C + G S Q
Sbjct: 76 ---DFVCNN------GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQ 126
Query: 3858 CINVEGSYKC----VCDQNFQERN 3877
CI V S++C CD E N
Sbjct: 127 CIPV--SWRCDGENDCDSGEDEEN 148
Score = 36.2 bits (82), Expect = 0.77
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 3/47 (6%)
Query: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADN-QLLDENGTTC 833
+P K+ N C VNNGGCS +C + G C CA +L+D TC
Sbjct: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK--TC 394
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 518 bits (1333), Expect = e-146
Identities = 278/740 (37%), Positives = 401/740 (54%), Gaps = 38/740 (5%)
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
C+ +F+C N CI WKCDGD+DC+DGSDE NC +C + F C N +C+P RW
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTCAESDFVCNNGQCVPSRWK 90
Query: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
CDG DC DES + C RTC++ + SCG + +CIP +W CD E+DC DE +C
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
Query: 963 EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-SCFDNQFRCSSGRCIPG 1021
TC P +F C SGRCIS + C+ DDC DGSDE+ C +C ++F+CS+ CIP
Sbjct: 150 GNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
Query: 1022 HWACDGDNDCGDFSDEAQINCTKEE-IHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
W CD D DC D SDE+ C ++ IH+ C +E QC G C+ WRCDG+ DC+
Sbjct: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTK--CPASEIQCG-SGECIHKKWRCDGDPDCK 265
Query: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSF--LCGP 1138
DGSDE C R C +F C G CI+ + C+G DC D SDE +C + GP
Sbjct: 266 DGSDEVNCPS--RTC-RPDQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 1139 PKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYL---CDECSLNNGGCSNHCSVVPGRGI 1195
K C + C+ K+CN ++DC D SDE +EC +NNGGCS+ C + G
Sbjct: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
Query: 1196 VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSV 1255
C C G +L D KTC +D C N CSQ+C K KC C G+++D+ C +V
Sbjct: 379 ECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 1256 DPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRG 1315
E +IF+ R +IR+I L +++Y LV LRNT+ALD L+W D+ + I+
Sbjct: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
Query: 1316 KLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAG 1375
+ + G V + + P + VDW+ IYW D+ I VA LDG+ R L
Sbjct: 497 SIDDKVGR---HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
Query: 1376 AMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGAWPNGLTVDH 1434
+ P +IA+DP G ++W+DW +IE A M+G R+ + D++ WPNG+T+D
Sbjct: 554 DLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQ---WPNGITLDL 609
Query: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494
+ R+ W D++ + S +G + +++ E+L+HP A++++ VYW D +
Sbjct: 610 IKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
Query: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCL----IN-HN 1549
ANK+TG ++ + D+ +YH QP N C + G C ++CL IN H+
Sbjct: 670 ANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHS 729
Query: 1550 RSAACACPHLMKLSSDKKTC 1569
C+CP + + + C
Sbjct: 730 PKYTCSCPSGYNVEENGRDC 749
Score = 499 bits (1286), Expect = e-140
Identities = 280/743 (37%), Positives = 405/743 (54%), Gaps = 46/743 (6%)
Query: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650
C +F+C +G CI +C+ + DC D SDEKNC C + F+ CN+
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAE--------SDFV-CNNGQ 83
Query: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQ-NKHKCEENYFSCP--SGRCILNTWICDGQKDC 2707
CV W CDG DC D SDE P Q + C + SC S +CI +W CDG+ DC
Sbjct: 84 -CVPSRWKCDGDPDCEDGSDE--SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
Query: 2708 EDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
+ G DE +C + +CS ++F CS+ +CIS++++C+G+DDC DG DE D C TC A F
Sbjct: 141 DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEF 198
Query: 2767 SCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP--NNTCDENAFMCHNKVCIPKQFV 2823
C S +C+P W+CD + DC D SDE L G P + C + C + CI K++
Sbjct: 199 QCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWR 257
Query: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883
CD D DC DGSDE C R C ++F C DG C+ ++ QC+G DC D SDE
Sbjct: 258 CDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----N 311
Query: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCSQD 2941
CK+ Q F C++G CI +C+ + DC D SDE + CHINECL GCS
Sbjct: 312 CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHI 370
Query: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP 3001
C+DL + Y+C C GF+L D KTC DIDEC + CSQ CIN G YKC C+ GY++
Sbjct: 371 CKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM-- 427
Query: 3002 DNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWID 3061
D G +EP LI + +IRKI + Y L + L N +A+D D + ++W D
Sbjct: 428 DLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
Query: 3062 SSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP 3121
S+ + G +K++ N P A+AVDW+ K +YW+D + I V+ L+G
Sbjct: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Query: 3122 TILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTI 3181
L + L+ P +++DP +G++YW D E I + GM+G ++ ++ I P +T+
Sbjct: 548 KFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
Query: 3182 DYVNRRLYWADENHIEFSNMD--GSHRHKVPN--QDIPGVIALTLFEDYIYWTDGKTKSL 3237
D + RLYW D S++D G R V + + +ALT+FED +YW DG+ +++
Sbjct: 608 DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
Query: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCM--INNGGCSHLCLLAP--- 3292
A+K +G++ +L+ + + DI VYH QP K+ C + NGGC +LCL AP
Sbjct: 668 YGANKFTGSELATLVNNLNDAQDIIVYHELVQPS-GKNWCEEDMENGGCEYLCLPAPQIN 726
Query: 3293 --GKTHTCACPTNFYLAADNRTC 3313
+TC+CP+ + + + R C
Sbjct: 727 DHSPKYTCSCPSGYNVEENGRDC 749
Score = 419 bits (1076), Expect = e-116
Identities = 266/760 (35%), Positives = 364/760 (47%), Gaps = 83/760 (10%)
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
K C P +FQC N CI W+CD DC D SDE+NC +TC DF+C NG CV SR+
Sbjct: 30 KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRW 89
Query: 3533 WCDGDFDCADGSDE--RNCE-TSCSKDQFRCS--NGQCIPAKWKCDGHEDCKYGEDEKSC 3587
CDGD DC DGSDE C +C + C + QCIP W+CDG DC GEDE++C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3588 EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV-TECKEDQFRCKNKAHCI 3646
+ TCS E+ C+S CIS + CNG+ DC+DGSDE+DC C +F+C + CI
Sbjct: 150 --GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CI 206
Query: 3647 PIRWLCDGIHDCVDGSDE--ENCERGGNI---CRADEFLCNNSLCKLHFWVCDGEDDCGD 3701
PI W+CD DC D SDE E C R I C A E C + C W CDG+ DC D
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
Query: 3702 NSDEAPDMCVKFLCPS--TRPHR--CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTY 3757
SDE CPS RP + C + C+ + CNGI +C D SDE +C
Sbjct: 267 GSDEVN-------CPSRTCRPDQFECEDGS-CIHGSRQCNGIRDCVDGSDEVNC-----K 313
Query: 3758 KARPC-KKDEFACSNKKCIPMDLQCDRLDDCGDGSDE--QGCRIAPTEYTCEDNVNPCGD 3814
C +F C + +CI + C++ DC D SDE + C I E VN G
Sbjct: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHIN------ECLVNNGGC 367
Query: 3815 DAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQ 3874
C + C C GF+ + + C D++EC G CS CIN++G YKC C + +Q
Sbjct: 368 SHICKDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQ 426
Query: 3875 E--RNNTCIAEGSEDQVLYIANDTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDVYY 3930
C A G E +++ N DI +G + I +E +D
Sbjct: 427 MDLATGVCKAVGKEPSLIF-TNRRDIRKIGL-------ERKEYIQLVEQLRNTVALDADI 478
Query: 3931 QRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSR 3990
+ W+ + IF I + R + P IAVDWV IYWTD
Sbjct: 479 AAQKLFWA-DLSQKAIFSASIDDKVGRHVK---MIDNVYNPAAIAVDWVYKTIYWTD--- 531
Query: 3991 MHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHS 4050
+ +I+V L+G L + EP +IAV+P G +YW+ G+ +
Sbjct: 532 ------------AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPA 579
Query: 4051 HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVS 4110
IE+A M+G RR LV ++Q P G+ +D R+YW D +L ++ SV +G + + +
Sbjct: 580 KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLK 639
Query: 4111 SKQGLLHPHRIDIFEDYIYGA-GPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQ 4169
S + L HP + IFED +Y G V+ KF + L N++ + +++ H Q
Sbjct: 640 SLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQ 699
Query: 4170 LDLPNPCLD----LACEFLCLLNPS------GATCVCPEG 4199
N C + CE+LCL P TC CP G
Sbjct: 700 PSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSG 739
Score = 291 bits (746), Expect = 8e-78
Identities = 145/353 (41%), Positives = 193/353 (54%), Gaps = 16/353 (4%)
Query: 3315 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374
+ C SQF+C +CI WKCD +DC DGSDE +C + C F C G C +
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRW 89
Query: 3375 ICDGENDCGDNSDEL--NCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
CDG+ DC D SDE C C + C + +CIPV+ RC+G++DC EDE +C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
+CSPD F C + + CIS+ +VC+ DC+D SDE +C TCG HEFQC ++CIP
Sbjct: 150 GNITCSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
Query: 3492 HWRCDSQNDCSDNSDE--ENCKPQ-----TCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
W CD DCSD SDE E C Q C + C +G+C+ ++ CDGD DC DGS
Sbjct: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 268
Query: 3545 DERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 3603
DE NC + +C DQF C +G CI +C+G DC G DE +C+ + ++ C S
Sbjct: 269 DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 3604 DGCISASLKCNGEYDCADGSDE--MDC-VTECKEDQFRCKNKAHCIPIRWLCD 3653
CI S CN E DC D SDE +C + EC + C + + I + CD
Sbjct: 329 GECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
Score = 269 bits (687), Expect = 5e-71
Identities = 136/345 (39%), Positives = 177/345 (51%), Gaps = 23/345 (6%)
Query: 3356 RCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLR 3415
+C+P +FQC G C + CDG+ DC D SDE NC C F C Q C+P +
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWK 90
Query: 3416 CNGQDDCGDEEDE--RDCPENSCSPDYFQCKT-TKHCISKLWVCDEDPDCADASDEANCD 3472
C+G DC D DE C +C C + CI W CD + DC DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
TC P EF C + CI ++ C+ Q+DCSD SDE +C P TC +F C+ C+ +
Sbjct: 151 NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
Query: 3533 WCDGDFDCADGSDE--RNC------ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 3584
CD D DC+D SDE C T C + +C +G+CI KW+CDG DCK G DE
Sbjct: 211 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Query: 3585 KSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC--VTEC-KEDQFRCKN 3641
+C S TC ++ C CI S +CNG DC DGSDE++C V +C +F+C++
Sbjct: 271 VNC--PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
Query: 3642 KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLC 3686
CI I +C+ DC D SDE E C +E L NN C
Sbjct: 329 -GECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLVNNGGC 367
Score = 226 bits (576), Expect = 4e-58
Identities = 150/536 (27%), Positives = 244/536 (45%), Gaps = 72/536 (13%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C E C C+ + W CDGDPDC D SDE CP C + C C+
Sbjct: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEV--NCPSRT---CRPDQFEC-EDGSCI 291
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQEL----------------------------------- 116
H S+ CNG+ DC DG DE V+C+ +
Sbjct: 292 HGSRQCNGIRDCVDGSDE-VNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Query: 117 ------LSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQT 168
++ C N C + C + C C GFE+ D ++C D DEC G CSQ
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQI 409
Query: 169 CRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLS 228
C N G Y C C GY M CKA + P L+ N I L + L
Sbjct: 410 CINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIFTNRRDIRKIGLERKEYIQLV 465
Query: 229 SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQM 288
N + LD + W + + + I K G + ++ + +N +
Sbjct: 466 EQLRNTV-ALDADIAAQKLFWADLSQKAIFSASID-DKVGR-----HVKMIDNVYNPAAI 518
Query: 289 AIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNV 348
A+DW+ + +Y+ D I V +G+ L + +L P +IAVDP++G ++++D+G
Sbjct: 519 AVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEP 578
Query: 349 AKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVI 408
AK+E+ M+G +R ++ + + P + LDL+ +YW+D L + VD G++R V+
Sbjct: 579 AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVL 638
Query: 409 QGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRT 466
+ + + H +T+FED +Y + +N + N+F G+++ +L+ + +A I +Y +
Sbjct: 639 KSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 467 QPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRSCKR 518
QP+ ++ CE D GGC ++CL ++ TC C +G+N+ +GR C+R
Sbjct: 699 QPSGKNW-CEEDMEN--GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQR 751
Score = 216 bits (549), Expect = 5e-55
Identities = 141/391 (36%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 2463 CELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGE 2522
CE S NG C L L +G +C D + CV K A S+F C NG+
Sbjct: 33 CEPSQFQCTNGRCITL-LWKCDGDEDCVDGSD-----EKNCVKKTC---AESDFVCNNGQ 83
Query: 2523 CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDN 2580
C+ + CDG P C+D SDE C R+CR C ++ +CIP CDGENDC
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
Query: 2581 SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDC-THFYKLGVK 2639
DE +C TC+ EF C+ G CI R+ CN DC+D SDE +C C H ++
Sbjct: 144 EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC--- 200
Query: 2640 TTGFIRCNSTSLCVLPTWICDGSNDCGDYSDEL--KCPVQN--KHKCEENYFSCPSGRCI 2695
STS C+ +W+CD DC D SDE +C Q KC + C SG CI
Sbjct: 201 --------STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
Query: 2696 LNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDS 2754
W CDG DC+DG DE +C S +C +QF C CI C+G DC DG DE +
Sbjct: 253 HKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Query: 2755 ICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
F C+ S C+ +C+ E+DC D SDE P C N + +N
Sbjct: 313 KNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDE-------PLKECHINECLVNN 364
Query: 2815 KVC--IPKQFVCDHDDDCGDGSD--ESPQCG 2841
C I K V ++ DC G + + CG
Sbjct: 365 GGCSHICKDLVIGYECDCAAGFELIDRKTCG 395
Score = 196 bits (498), Expect = 4e-49
Identities = 111/323 (34%), Positives = 156/323 (48%), Gaps = 30/323 (9%)
Query: 3314 LSNCTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCAL 3371
+ C + C + +CIP W+CD +DC G DE ++C C P F C +G C
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENCGNITCSPDEFTCSSGRCIS 168
Query: 3372 PAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDE--- 3428
F+C+G++DC D SDEL+C C + +F+C+ CIP++ C+ DC D+ DE
Sbjct: 169 RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLE 227
Query: 3429 ----RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCK 3484
+ C QC + + CI K W CD DPDC D SDE NC +TC P +F+C+
Sbjct: 228 QCGRQPVIHTKCPASEIQCGSGE-CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
Query: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCK--PQTCTLKDFLCANGDCVSSRFWCDGDFDCAD 3542
+ +CI +C+ DC D SDE NCK Q F C +G+C+ C+ + DC D
Sbjct: 287 DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
Query: 3543 GSDERNCETSCSKDQFRCSNGQCIP-AKWKCDGHE-DCKYG---EDEKSCEPASPTCSSR 3597
SDE E C ++ +NG C K G+E DC G D K+C
Sbjct: 347 WSDEPLKE--CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDE----- 399
Query: 3598 EYICASDG-CISASLKCNGEYDC 3619
C + G C + G Y C
Sbjct: 400 ---CQNPGICSQICINLKGGYKC 419
Score = 181 bits (459), Expect = 1e-44
Identities = 126/371 (33%), Positives = 180/371 (48%), Gaps = 30/371 (8%)
Query: 476 EVDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGI 534
++D PG CS IC+ L YK C C G+ + CK E L + R
Sbjct: 396 DIDECQNPGICSQICINLKGGYK---CECSRGYQMDLATGVCKAVGKEPSLIFTNRRD-- 450
Query: 535 VRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETI 593
+R + L K EY+ +E L N ALD +++AD + I ID R
Sbjct: 451 IRKIGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
Query: 594 LKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVD 653
+ D++ N IAVDW+ +YWT D KTI+VA L+ RK L ++ P I VD
Sbjct: 508 MIDNVYNPAAIAVDWVYKTIYWT-DAASKTISVATLD--GTKRKFLFNSDLREPASIAVD 564
Query: 654 PVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCD 713
P++G++YW+DW E +IEKA M+GF+R+ VT+ + WPNG+TLD + LYW D
Sbjct: 565 PLSGFVYWSDWGEP------AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLD 618
Query: 714 AYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEV 771
+ + V LNG R+IV E L HP L+ + V+W D N +++ + T SE+
Sbjct: 619 SKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEL 678
Query: 772 TLLRHERPPLFGLQIYDPRKQ-QGDNMCR--VNNGGCSTLCLAIP------GGRVCACAD 822
L + + +Y Q G N C + NGGC LCL P C+C
Sbjct: 679 ATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPS 738
Query: 823 NQLLDENGTTC 833
++ENG C
Sbjct: 739 GYNVEENGRDC 749
Score = 163 bits (412), Expect = 4e-39
Identities = 117/413 (28%), Positives = 194/413 (46%), Gaps = 28/413 (6%)
Query: 1792 WADQNLAQ--LGTCSKRDGRNPTILRNKTSG-----VVHMKVYDKEAQQGSNSCQLNNGG 1844
W+D+ L + + C +G I ++ G ++ D++ + CQ N G
Sbjct: 347 WSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGI 405
Query: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI--ESFLMYSVHEGIRGIPLEPSDKMDA 1902
CSQ+C+ + C C+ GY + C+ + E L+++ IR I LE + +
Sbjct: 406 CSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL 464
Query: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI-ITNGLGRVEGIAVD 1961
+ + T V +D ++W D+ I A D + + + + IAVD
Sbjct: 465 VEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
Query: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021
W+ IYWTD I VA L+G+ R + + L +P SIAV P G ++W++WG+ I
Sbjct: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
Query: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081
KA ++G ++ LV+ I WPNGI++D +++LYW D++ + +DL G +R +VL
Sbjct: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRIVLKS 640
Query: 2082 SN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRV 2139
++ +F +YW D N +V +K +E T+ L + V
Sbjct: 641 LEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
Query: 2140 REKGTNVCARD--NGGCKQLCL-----YRGNSRRTCACAHGY-LAEDGVTCLR 2184
+ G N C D NGGC+ LCL + + TC+C GY + E+G C R
Sbjct: 699 QPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQR 751
Score = 145 bits (366), Expect = 9e-34
Identities = 73/175 (41%), Positives = 100/175 (57%), Gaps = 13/175 (7%)
Query: 996 GSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNG 1055
G+ G C +QF+C++GRCI W CDGD DC D SDE NC K+ C
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKT------CAE 74
Query: 1056 NEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCD-HKTKFSCWSTGRCINKAW 1114
++F C+ +G CVP W+CDG+ DCEDGSDE +R C H+ ST +CI +W
Sbjct: 75 SDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHST-QCIPVSW 132
Query: 1115 VCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
CDG+ DC+ DE++C + C P + C++ C+ +CNG+ DC DGSDE
Sbjct: 133 RCDGENDCDSGEDEENCGNITCSPDEFTCSSGR--CISRNFVCNGQDDCSDGSDE 185
Score = 135 bits (340), Expect = 9e-31
Identities = 69/185 (37%), Positives = 91/185 (49%), Gaps = 9/185 (4%)
Query: 839 EALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC-----FNHSCPDDQFKC 893
+ P C A EF+C CI W CD D DC D SDE C + CP + +C
Sbjct: 187 DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC 246
Query: 894 QNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCG 953
+ CI K+W CDG DC DE N C +RTC+ DQF C +G CI + C+ DC
Sbjct: 247 GSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
Query: 954 DQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRC 1013
D +DE+ C +F C+SG CI C+ + DC D SDE + C N+
Sbjct: 305 DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEP--LKECHINECLV 362
Query: 1014 SSGRC 1018
++G C
Sbjct: 363 NNGGC 367
Score = 134 bits (337), Expect = 2e-30
Identities = 93/356 (26%), Positives = 168/356 (47%), Gaps = 23/356 (6%)
Query: 1538 GPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFN 1595
G CS +C IN C C ++ C + K L++ R +IR + ++ +
Sbjct: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 1596 FITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING-TGLETVISRDIQSIRGL 1654
+ V + + +D D + ++L+W D+ + I A I+ G + ++ + +
Sbjct: 463 QL----VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1655 AVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLYWTDGN 1713
AVDWV + +YW + I+VA LDG+ + + + + +P +A P+ G +YW+D
Sbjct: 519 AVDWVYKTIYWTDAA--SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
Query: 1714 T---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEV 1769
I A M+G + + L + P G+++D ++++LYW+ S ++ +L+G + +
Sbjct: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
Query: 1770 IESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDK 1829
+ E L ALTI + +++W D + +K G L N + + VY +
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
Query: 1830 EAQ-QGSNSCQ--LNNGGCSQLCLPTSETT-----RTCMCTVGYYLQKNRMSCQGI 1877
Q G N C+ + NGGC LCLP + TC C GY +++N CQ I
Sbjct: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI 752
Score = 108 bits (270), Expect = 1e-22
Identities = 80/270 (29%), Positives = 113/270 (41%), Gaps = 69/270 (25%)
Query: 2793 ELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC 2852
E G C+ + F C N CI + CD D+DC DGSDE C + C +F C
Sbjct: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC 79
Query: 2853 ADGRCLLNTQWQCDGDFDCPDHSDEAPL------------------------------NP 2882
+G+C + ++W+CDGD DC D SDE+P
Sbjct: 80 NNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGEN 138
Query: 2883 KCKSAEQ-------SCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKV 2935
C S E +C+ F C +GRCI +C+ +DDC DGSDE +C C + +
Sbjct: 139 DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEF 198
Query: 2936 SGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD-----IDECS------SGFPCSQ-QCI 2983
+ C +P+S+ C DD C D +++C + P S+ QC
Sbjct: 199 QCSTSSC--IPISWVC---------DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 2984 NTYGTYKCLCTDGYEIQPDNPNGCKSLSDE 3013
+ +K DG PD CK SDE
Sbjct: 248 SGECIHKKWRCDG---DPD----CKDGSDE 270
Score = 108 bits (270), Expect = 1e-22
Identities = 90/380 (23%), Positives = 170/380 (44%), Gaps = 39/380 (10%)
Query: 2152 GGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNL 2208
G C Q+C+ + C C+ GY LA + E L+++ R ++ I L + +
Sbjct: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 2209 NSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI--QLIKDNWEDRQVIVE 2266
+ +N +AL D ++F++D I I D +++
Sbjct: 463 -------QLVEQLRNTVALDADI-----AAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
Query: 2267 NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALD 2326
NV + +A + T+YWT + + +I+ T+D T+ + S+ P +A+D
Sbjct: 511 NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIAVD 564
Query: 2327 ECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGK 2386
++W++W E I ++ + G + + +V+ DI PNG+T+D +LY+ D L
Sbjct: 565 PLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
Query: 2387 IERCEYDGSQRHVIVKSGP--GTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRS 2444
+ + +G R +++KS L+L ++++ ++W D A+ +NK+TG + L +
Sbjct: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN 683
Query: 2445 DIPHQPMGII----AVANDTNSCELSPCALLNGGCHDLCLLTP-----NGRVNCSCRGDR 2495
++ I+ + N CE + NGGC LCL P + + CSC
Sbjct: 684 NLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
Query: 2496 ILLEDNRCVTKNSSCNAYSE 2515
+ E+ R + + A SE
Sbjct: 741 NVEENGRDCQRINVTTAVSE 760
Score = 73.9 bits (180), Expect = 3e-12
Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 27/186 (14%)
Query: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIAC-LGT 87
++ C +F+C++ CV W CDGDPDC D SDES + C C ++ I+C +
Sbjct: 69 KKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHS 124
Query: 88 NKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDGF 144
+C+ +S C+G DC G DE NC + C ++ C+ R +R + +G
Sbjct: 125 TQCIPVSWRCDGENDCDSGEDE--------ENCGNITCSPDEFTCSSGRCISRNFVCNGQ 176
Query: 145 EITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCK----AKIEPT 200
+ DG D+ +CA TC + T SC+ + D+ C +E
Sbjct: 177 DDCSDG---SDELDCAP-PTCG---AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC 229
Query: 201 DRPPIL 206
R P++
Sbjct: 230 GRQPVI 235
Score = 60.8 bits (146), Expect = 3e-08
Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C+P +F C + C++ W CDGD DC D SDE C V+ C + C +CV
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEK--NC---VKKTCAESDFVC-NNGQCV 85
Query: 92 HLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQLNCQYKCTM-VRNSTRCYCEDGFEITED 149
C+G DC DG DE C +++C T + S RC E+ + ED
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 150 GRSC 153
+C
Sbjct: 146 EENC 149
Score = 48.9 bits (115), Expect = 1e-04
Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 36/144 (25%)
Query: 3752 GGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP 3811
G T + C+ +F C+N +CI + +CD +DC DGSDE+ C + TC ++
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC----VKKTCAES--- 75
Query: 3812 CGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCED----------LNECLVF----GTCSHQ 3857
D CN +C P + + CED + C + G S Q
Sbjct: 76 ---DFVCNN------GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQ 126
Query: 3858 CINVEGSYKC----VCDQNFQERN 3877
CI V S++C CD E N
Sbjct: 127 CIPV--SWRCDGENDCDSGEDEEN 148
Score = 36.2 bits (82), Expect = 0.77
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 3/47 (6%)
Query: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADN-QLLDENGTTC 833
+P K+ N C VNNGGCS +C + G C CA +L+D TC
Sbjct: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK--TC 394
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 492 bits (1266), Expect = e-138
Identities = 276/751 (36%), Positives = 390/751 (51%), Gaps = 78/751 (10%)
Query: 838 GEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC--QN 895
G A+ C+ EF+C++ CI +W CDG +C DGSDE C + +C F C +
Sbjct: 20 GTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRV 79
Query: 896 NRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQ 955
NRCIP+ W CDG DC + DE Q C +TC D+F C +G+CI R ++CD + DC D
Sbjct: 80 NRCIPQFWRCDGQVDCDNGSDE--QGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
Query: 956 TDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDE-----------VGCVH 1004
+DE ASC TC P F C S CI W CD+D DC DGSDE G
Sbjct: 138 SDE-ASCPVLTCGP-ASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
Query: 1005 SCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDG 1064
C +F C SG CI W CDG DC D SDE NC + A C +EFQC DG
Sbjct: 196 PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEE--NC------AVATCRPDEFQC-SDG 246
Query: 1065 NCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
NC+ +CD E DC+D SDE GC + LC+ KF C S G CI VC+ DC D
Sbjct: 247 NCIHGSRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHS-GECITLDKVCNMARDCRD 304
Query: 1125 QSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCS 1184
SDE P K C +EC NNGGCS
Sbjct: 305 WSDE------------------------PIKECG--------------TNECLDNNGGCS 326
Query: 1185 NHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWK 1244
+ C+ + G C CP+G QL + CE +D C + CSQ+C + KC C EG++
Sbjct: 327 HVCNDLK-IGYECLCPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQ 384
Query: 1245 LDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYW 1304
LD ++C +V A++ F+ RHE+R++ L + +Y+ L+P LRN +ALD + +YW
Sbjct: 385 LDPHTKACKAVGSI-AYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYW 443
Query: 1305 TDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKL 1364
+D+ + I +L + GVS+ + V+ + P+GL VDWI NIYW DS L + VA
Sbjct: 444 SDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADT 503
Query: 1365 DGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTG 1424
G R TL PRAI +DP +G ++WTDW +I+ ++G ++ +
Sbjct: 504 KGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTE--NI 560
Query: 1425 AWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYW 1484
WPNG+T+D R+ W D++ +I S +G N I+ + L+HPF+++++ +V+W
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
Query: 1485 TDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAND-GKGPCSHM 1543
TD + AN+ TG +V+++ + P D+ ++H QP+ N C G C ++
Sbjct: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680
Query: 1544 CL----IN-HNRSAACACPHLMKLSSDKKTC 1569
CL IN H+ CACP M L+ D ++C
Sbjct: 681 CLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 419 bits (1078), Expect = e-116
Identities = 242/696 (34%), Positives = 359/696 (51%), Gaps = 43/696 (6%)
Query: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS--GRCILNTWICDGQKDCED 2709
C+ W+CDGS +C D SDE + + C+ FSC RCI W CDGQ DC++
Sbjct: 39 CISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDN 97
Query: 2710 GRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSC 2768
G DE C +CS ++F C KCIS+ ++CD + DC DG DE+ C +TC F C
Sbjct: 98 GSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS--CPVLTCGPASFQC 155
Query: 2769 QGSRACVPRHWLCDGERDCPDGSDELSTAGC-------APNNTCDENAFMCHNKVCIPKQ 2821
S C+P+ W CD + DC DGSDE C ++ C F C + CI
Sbjct: 156 NSS-TCIPQLWACDNDPDCEDGSDEWPQR-CRGLYVFQGDSSPCSAFEFHCLSGECIHSS 213
Query: 2822 FVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLN 2881
+ CD DC D SDE C C +EF C+DG C+ ++ QCD ++DC D SDE
Sbjct: 214 WRCDGGPDCKDKSDEE-NCAVATCRPDEFQCSDGNCIHGSR-QCDREYDCKDMSDEVG-- 269
Query: 2882 PKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCS 2939
C + + F C +G CI +C+ DC D SDE + C NECL GCS
Sbjct: 270 --CVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNN-GGCS 326
Query: 2940 QDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEI 2999
C DL + Y+C C GFQL + C DIDEC CSQ C+N G YKC C +G+++
Sbjct: 327 HVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQL 385
Query: 3000 QPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYW 3059
P + CK++ +L + HE+RK++ D S YT L L NV+A+D + IYW
Sbjct: 386 DP-HTKACKAVGSIA-YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYW 443
Query: 3060 IDSSRPN--GSRINRMC-LNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKL 3116
D S+ ++++R ++ D + + P+ LAVDWI N+YW+D+ + V+
Sbjct: 444 SDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADT 503
Query: 3117 NGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRP 3176
G+ L + PR + +DP G++YW D I + G++G + ++ I P
Sbjct: 504 KGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWP 563
Query: 3177 MALTIDYVNRRLYWADENHIEFSNMD--GSHRHKVPNQD--IPGVIALTLFEDYIYWTDG 3232
+T+D ++ RLYW D S++D G +R + + + +L +FED ++WTD
Sbjct: 564 NGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDI 623
Query: 3233 KTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLC---MINNGGCSHLCL 3289
+++ A++ +G+D L + + D+ ++H+ QP + C ++NGGC +LCL
Sbjct: 624 INEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPR-GVNWCERTTLSNGGCQYLCL 682
Query: 3290 LAP-----GKTHTCACPTNFYLAADNRTCLSNCTAS 3320
AP TCACP LA D R+CL+ A+
Sbjct: 683 PAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
Score = 337 bits (863), Expect = 2e-91
Identities = 221/715 (30%), Positives = 325/715 (45%), Gaps = 102/715 (14%)
Query: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS--DGCISAS 3610
C +++F+C +G+CI KW CDG +C+ G DE S TC S ++ C + CI
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 3611 LKCNGEYDCADGSDEMDCVTE-CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCER 3669
+C+G+ DC +GSDE C + C +D+FRC + CI +++CD DC+DGSDE +C
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD-GKCISRQFVCDSDRDCLDGSDEASCPV 145
Query: 3670 GGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFL--------CPSTRPH 3721
C F CN+S C W CD + DC D SDE P C C + H
Sbjct: 146 --LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFH 203
Query: 3722 RCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQC 3781
C + C+ S C+G +C D SDE++C C+ DEF CS+ CI QC
Sbjct: 204 -CLSGE-CIHSSWRCDGGPDCKDKSDEENCA------VATCRPDEFQCSDGNCIHGSRQC 255
Query: 3782 DRLDDCGDGSDEQGCRIA-----PTEYTC----------------------EDNVNPCGD 3814
DR DC D SDE GC P ++ C ++ + CG
Sbjct: 256 DREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGT 315
Query: 3815 DA----------YCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGS 3864
+ CN +K C C GFQ + R+CED++EC TCS C+N+EG
Sbjct: 316 NECLDNNGGCSHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDECQDPDTCSQLCVNLEGG 374
Query: 3865 YKCVCDQNFQERNNT--CIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSR 3922
YKC C++ FQ +T C A GS L+ N ++ D + + + N R
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSI-AYLFFTNRHEVRKMTL------DRSEYTSLIPNLR 427
Query: 3923 -ITGMDVYYQRDMIIWS--TQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWV 3979
+ +D + I WS +Q R HG +I + + P +AVDW+
Sbjct: 428 NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDT---VISRDIQAPDGLAVDWI 484
Query: 3980 AGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRG 4039
NIYWTD S+ +++V G L +P AI V+P G
Sbjct: 485 HSNIYWTD---------------SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHG 529
Query: 4040 MMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVL 4099
MYWT G + I++ ++G LV +N+Q P G+ +D S R+YW D +L I S+
Sbjct: 530 FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Query: 4100 YDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKT 4158
+G N + ++ L HP + +FED ++ N +F + V LA N+
Sbjct: 590 VNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSP 649
Query: 4159 KGVLISHRYKQLDLPNPC-----LDLACEFLCL----LNPSGA--TCVCPEGKYL 4202
+ +++ H Q N C + C++LCL +NP TC CP+G L
Sbjct: 650 EDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLL 704
Score = 237 bits (604), Expect = 2e-61
Identities = 136/383 (35%), Positives = 181/383 (47%), Gaps = 34/383 (8%)
Query: 3306 LAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDD-CPEFRCQPGRFQC 3364
LAA C ++F+C+ KCI + W CD +C DGSDE + C C+ G F C
Sbjct: 16 LAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSC 75
Query: 3365 G--TGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDC 3422
G C + CDG+ DC + SDE C C +F+C + KCI C+ DC
Sbjct: 76 GGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRC-HDGKCISRQFVCDSDRDC 134
Query: 3423 GDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDE--ANC--------D 3472
D DE CP +C P FQC ++ CI +LW CD DPDC D SDE C D
Sbjct: 135 LDGSDEASCPVLTCGPASFQCNSST-CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGD 193
Query: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
C EF C + CI WRCD DC D SDEENC TC +F C++G+C+
Sbjct: 194 SSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSR 253
Query: 3533 WCDGDFDCADGSDERNC--ETSC-SKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
CD ++DC D SDE C T C ++F+C +G+CI C+ DC+ DE E
Sbjct: 254 QCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE- 312
Query: 3590 ASPTCSSREYICASDGC--ISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
C + E + + GC + LK E C DG ++ C ED C++ C
Sbjct: 313 ----CGTNECLDNNGGCSHVCNDLKIGYECLCPDGF-QLVAQRRC-EDIDECQDPDTCSQ 366
Query: 3648 IRWLCDGIHDCVDGSDEENCERG 3670
+ +G + C CE G
Sbjct: 367 LCVNLEGGYKC-------QCEEG 382
Score = 221 bits (562), Expect = 2e-56
Identities = 197/725 (27%), Positives = 307/725 (42%), Gaps = 139/725 (19%)
Query: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDC--GDEEDERDCPENSCSPDYFQCK-TTKHCISK 3452
C +F+C ++ KCI C+G +C G +E + C +C F C CI +
Sbjct: 27 CERNEFQC-QDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 3453 LWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP 3512
W CD DC + SDE C KTC EF+C + CI + CDS DC D SDE +C
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
Query: 3513 QTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE--RNC---------ETSCSKDQFRCS 3561
TC F C + C+ + CD D DC DGSDE + C + CS +F C
Sbjct: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL 205
Query: 3562 NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCAD 3621
+G+CI + W+CDG DCK DE++C A TC E+ C+ CI S +C+ EYDC D
Sbjct: 206 SGECIHSSWRCDGGPDCKDKSDEENC--AVATCRPDEFQCSDGNCIHGSRQCDREYDCKD 263
Query: 3622 GSDEMDC--VTECK-EDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE 3678
SDE+ C VT C+ ++F+C + CI + +C+ DC D SDE E G N C
Sbjct: 264 MSDEVGCVNVTLCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDEPIKECGTNEC---- 318
Query: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKF--LCPSTRPHRCRNNRICLQSEQMC 3736
L NN C VC+ D+ + + LCP + L +++ C
Sbjct: 319 -LDNNGGCS---HVCN-------------DLKIGYECLCP---------DGFQLVAQRRC 352
Query: 3737 NGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
IDEC D D C ++ C E KC QC E+G
Sbjct: 353 EDIDEC---QDPDTC-------SQLCVNLE---GGYKC-----QC-----------EEGF 383
Query: 3797 RIAPTEYTCEDNVNPCGDDAYC-----NQIKTSVFCRCK-PGFQRNMKNRQC-------- 3842
++ P C+ G AY ++++ R + N++N
Sbjct: 384 QLDPHTKACK----AVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASN 439
Query: 3843 ----EDLNECLVFGTCSHQCINVEG--SYKCVCDQNFQERNNTCIAEGSEDQVLYIANDT 3896
DL++ ++ CS Q G SY V ++ Q + + D + T
Sbjct: 440 RIYWSDLSQRMI---CSTQLDRAHGVSSYDTVISRDIQAPDGLAV-----DWIHSNIYWT 491
Query: 3897 D-ILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGRE 3955
D +LG + + G ++ E+ S+ + V + W+ P I ++G +
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
Query: 3956 KRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNG 4015
L+ + P I +D ++G +YW D S++H SI+ +NG
Sbjct: 552 ----IYSLVTENIQWPNGITLDLLSGRLYWVD-SKLH--------------SISSIDVNG 592
Query: 4016 PNCTRLLTN--MAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRP 4073
N +L + P+++AV + ++WT + + + + G+ +L + NL P
Sbjct: 593 GNRKTILEDEKRLAHPFSLAVFEDK--VFWTDIINEAIFSANRLTGSDVNLLAE-NLLSP 649
Query: 4074 TGLAV 4078
+ +
Sbjct: 650 EDMVL 654
Score = 219 bits (559), Expect = 4e-56
Identities = 157/534 (29%), Positives = 244/534 (45%), Gaps = 60/534 (11%)
Query: 28 DQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE---SLDTC-PEEV---------- 73
D C EF C C+ SW CDG PDC D SDE ++ TC P+E
Sbjct: 193 DSSPCSAFEFHCLSG-ECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHG 251
Query: 74 ---------------EIKCPLNHIACLGTNK-------CVHLSQLCNGVLDCPDGYDEGV 111
E+ C +N C G NK C+ L ++CN DC D DE +
Sbjct: 252 SRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPI 310
Query: 112 H---CQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQT 168
E L N C + C ++ C C DGF++ R C+D DEC TCSQ
Sbjct: 311 KECGTNECLDN--NGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQL 367
Query: 169 CRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLS 228
C N G Y C C EG+ + P ++CKA L N + L+ S+ +L
Sbjct: 368 CVNLEGGYKCQCEEGFQLDPHTKACKA----VGSIAYLFFTNRHEVRKMTLDRSEYTSLI 423
Query: 229 SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQM 288
N + LD + I W S S + Q+ +A G++ T+ I + +
Sbjct: 424 P-NLRNVVALDTEVASNRIYW--SDLSQRMICSTQLDRAHGVSSYDTV-ISRDIQAPDGL 479
Query: 289 AIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNV 348
A+DW+ N+Y+ D V + V ++ G TL P+AI VDP+ G +++TD+G
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 349 AKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVI 408
AK+++ ++G++ ++ + P + LDL++ +YWVD L + +D G NR T++
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
Query: 409 QG-RQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGIRIYQKRT 466
+ +++ H + + VFED ++ T+ N I NR G+D++ L + + + + ++ T
Sbjct: 600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLT 659
Query: 467 QPTVRSHACEVDPYGMPGGCSHICLLSSSYKTR----TCRCRTGFNLGSDGRSC 516
QP + CE GGC ++CL + TC C G L D RSC
Sbjct: 660 QPR-GVNWCERTTLS-NGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 201 bits (512), Expect = 1e-50
Identities = 128/363 (35%), Positives = 168/363 (46%), Gaps = 38/363 (10%)
Query: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR--RCIPHGKLC 2571
+EF+C +G+CI Y+ CDG C+D SDE C + +C+ G C R RCIP C
Sbjct: 30 NEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRC 89
Query: 2572 DGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
DG+ DC + SDE C TC+ EFRC DG CI R C+ + DC D SDE +C C
Sbjct: 90 DGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTC- 148
Query: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDE-------LKCPVQNKHKCEE 2684
+CNS S C+ W CD DC D SDE L + C
Sbjct: 149 --------GPASFQCNS-STCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSA 199
Query: 2685 NYFSCPSGRCILNTWICDGQKDCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGED 2743
F C SG CI ++W CDG DC+D DE +C ++C ++F CS CI CD E
Sbjct: 200 FEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREY 259
Query: 2744 DCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSD----ELSTAGC 2799
DC D DE + + + F C S C+ +C+ RDC D SD E T C
Sbjct: 260 DCKDMSDEVGCVNVTLCEGPNKFKCH-SGECITLDKVCNMARDCRDWSDEPIKECGTNEC 318
Query: 2800 APNN-----TCDENAF----MCHNKVCIPKQFVCDHDDDCGDGSDESPQC----GYRQCG 2846
NN C++ +C + + Q C+ D+C D S C G +C
Sbjct: 319 LDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQ 378
Query: 2847 TEE 2849
EE
Sbjct: 379 CEE 381
Score = 197 bits (500), Expect = 3e-49
Identities = 134/382 (35%), Positives = 196/382 (51%), Gaps = 35/382 (9%)
Query: 470 VRSHACE-VDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFY 527
V CE +D P CS +C+ L YK C+C GF L ++CK + +LF+
Sbjct: 347 VAQRRCEDIDECQDPDTCSQLCVNLEGGYK---CQCEEGFQLDPHTKACKAVGSIAYLFF 403
Query: 528 GKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG 587
VR M L+ EY I NL N ALD +N IY++D + +I ++D
Sbjct: 404 TNRHE--VRKMTLDRS---EYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDR 458
Query: 588 ----TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE 643
+ +T++ D+ +G+AVDWI +N+YWT D T++VA + RKTL
Sbjct: 459 AHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT-DSVLGTVSVA--DTKGVKRKTLFREN 515
Query: 644 MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLD 703
S PR IVVDPV+G+MYWTDW + +I+K ++G + VT + WPNG+TLD
Sbjct: 516 GSKPRAIVVDPVHGFMYWTDW------GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 569
Query: 704 FHTNTLYWCDAYYDHIEKVFLNGTHRK-IVYSGRELNHPFGLSHHGNYVFWTDYMNGSIF 762
+ LYW D+ I + +NG +RK I+ + L HPF L+ + VFWTD +N +IF
Sbjct: 570 LLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF 629
Query: 763 QLDLIT-SEVTLLRHE-RPPLFGLQIYDPRKQQGDNMCR---VNNGGCSTLCLAIPGGR- 816
+ +T S+V LL P + ++ + +G N C ++NGGC LCL P
Sbjct: 630 SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINP 689
Query: 817 -----VCACADNQLLDENGTTC 833
CAC D LL + +C
Sbjct: 690 HSPKFTCACPDGMLLARDMRSC 711
Score = 169 bits (427), Expect = 8e-41
Identities = 122/425 (28%), Positives = 199/425 (46%), Gaps = 50/425 (11%)
Query: 1792 WADQNLAQLGT--CSKRDGRNPTILRNKTSGVVHM-----KVYDKEAQQGSNSCQLNNGG 1844
W+D+ + + GT C +G + + G + ++ + + + CQ +
Sbjct: 305 WSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDT 363
Query: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIES--FLMYSVHEGIRGIPLEPSDKMDA 1902
CSQLC+ E C C G+ L + +C+ + S +L ++ +R + L+ S+
Sbjct: 364 CSQLCV-NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
Query: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWK----EDIITNGLGRVEGI 1958
+ + V +D ++ IYW+D+ I + D+ + +I+ + +G+
Sbjct: 423 IPNLRNV---VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 1959 AVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQM 2018
AVDWI NIYWTD + VA G R + + +PR+I V P G ++WT+WG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 2019 PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMV 2078
I K L+G + LV+ I WPNGI++D +LYW D++ I ID+ GGNR+ +
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV-NGGNRKTI 598
Query: 2079 LSGSN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNL------ 2130
L FS+AVF ++W+D N+A + TG VNL
Sbjct: 599 LEDEKRLAHPFSLAVFEDKVFWTDII-----------NEAIFSANRLTGSDVNLLAENLL 647
Query: 2131 --KEVKIF-NRVREKGTNVCAR---DNGGCKQLCL-----YRGNSRRTCACAHG-YLAED 2178
+++ +F N + +G N C R NGGC+ LCL + + TCAC G LA D
Sbjct: 648 SPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD 707
Query: 2179 GVTCL 2183
+CL
Sbjct: 708 MRSCL 712
Score = 154 bits (388), Expect = 3e-36
Identities = 98/355 (27%), Positives = 169/355 (47%), Gaps = 27/355 (7%)
Query: 1540 CSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFNFI 1597
CS +C +N C C +L K C + +L + R E+R + +D + +
Sbjct: 364 CSQLC-VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
Query: 1598 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING----TGLETVISRDIQSIRG 1653
+P++ +V +D + + R+YW+D+ + I ++ + +TVISRDIQ+ G
Sbjct: 423 ----IPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 1654 LAVDWVSRNLYWISSEFDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTDG 1712
LAVDW+ N+YW S ++VA G KT KP+ + PV G +YWTD
Sbjct: 479 LAVDWIHSNIYWTDSVLGT--VSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW 536
Query: 1713 NTINMANMDGSNS----KILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLE 1768
T G N ++ +N + P G+++D + +LYW+ S +I+ +++GGN +
Sbjct: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
Query: 1769 VIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYD 1828
I ++ L +L + + K++W D + + ++ G + +L M ++
Sbjct: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
Query: 1829 KEAQ-QGSNSCQ---LNNGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
Q +G N C+ L+NGGC LCLP + TC C G L ++ SC
Sbjct: 657 NLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 113 bits (283), Expect = 4e-24
Identities = 112/445 (25%), Positives = 181/445 (40%), Gaps = 99/445 (22%)
Query: 2139 VREKGTNVCARDNGGCKQLCLYRGNSRRT---CACAHGYLA------------------- 2176
++E GTN C +NGGC +C N + C C G+
Sbjct: 310 IKECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCS 365
Query: 2177 ------EDGVTCLRHEG-----------------YLLYSGRTILKSIHL--SDETNLNSP 2211
E G C EG YL ++ R ++ + L S+ T+L
Sbjct: 366 QLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPN 425
Query: 2212 IRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQ--------V 2263
+R NV+AL + +NRI++SD + ++I DR V
Sbjct: 426 LR---------NVVALDTEV-----ASNRIYWSDL---SQRMICSTQLDRAHGVSSYDTV 468
Query: 2264 IVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVL 2323
I ++ + +GLA +YWT S +++ + RE P +
Sbjct: 469 ISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE------NGSKPRAI 522
Query: 2324 ALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGS 2383
+D M+WT+W I + L G + +V+ +I PNG+T+D + +LY+ D
Sbjct: 523 VVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Query: 2384 LGKIERCEYDGSQRHVIVKSGPGTF--LSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKI 2441
L I + +G R I++ SLAV+++ +FW+D AI +N+ TG D +
Sbjct: 582 LHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641
Query: 2442 LRSDIPHQPMGIIAVANDT-----NSCELSPCALLNGGCHDLCLLTP-----NGRVNCSC 2491
L ++ P ++ N T N CE + L NGGC LCL P + + C+C
Sbjct: 642 LAENL-LSPEDMVLFHNLTQPRGVNWCERT--TLSNGGCQYLCLPAPQINPHSPKFTCAC 698
Query: 2492 RGDRILLEDNR-CVTKNSSCNAYSE 2515
+L D R C+T+ + A E
Sbjct: 699 PDGMLLARDMRSCLTEAEAAVATQE 723
Score = 112 bits (280), Expect = 8e-24
Identities = 76/238 (31%), Positives = 108/238 (45%), Gaps = 41/238 (17%)
Query: 2794 LSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQ-CGYRQCGTEEFSC 2852
L+ AG A + C+ N F C + CI ++VCD +C DGSDES + C C + +FSC
Sbjct: 16 LAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSC 75
Query: 2853 AD--GRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLC 2910
RC+ W+CDG DC + SDE PK +C+ F C +G+CI +C
Sbjct: 76 GGRVNRCIPQF-WRCDGQVDCDNGSDEQGCPPK------TCSQDEFRCHDGKCISRQFVC 128
Query: 2911 DNKDDCGDGSDERNCHINEC----LSKKVSGC---------SQDCQDLPVSYKCKCWPGF 2957
D+ DC DGSDE +C + C S C DC+D + +C +
Sbjct: 129 DSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLY 188
Query: 2958 QLKDDGKTCVDID-ECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE 3014
+ D C + C SG +CI + +++C D CK SDEE
Sbjct: 189 VFQGDSSPCSAFEFHCLSG-----ECI--HSSWRC----------DGGPDCKDKSDEE 229
Score = 111 bits (278), Expect = 1e-23
Identities = 91/321 (28%), Positives = 131/321 (40%), Gaps = 70/321 (21%)
Query: 2490 SCRGDRILLEDNRCVTKNSSCNAYSE-------------------FECGNGECIDYQLTC 2530
+C D D +C+++ C++ + F+C + CI C
Sbjct: 108 TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWAC 167
Query: 2531 DGIPHCKDKSDEKLLYC--------ENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSD 2582
D P C+D SDE C ++ C C + CI CDG DC D SD
Sbjct: 168 DNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSD 227
Query: 2583 ELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC-NNTDCTHFYKLGVKTT 2641
E +C V+TC EF+C+DG CI S +C++ DC D SDE C N T C K
Sbjct: 228 EENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNK------ 281
Query: 2642 GFIRCNSTSLCVLPTWICDGSNDCGDYSDE-------LKCPVQN---KHKCEENYFS--- 2688
+C+S C+ +C+ + DC D+SDE +C N H C +
Sbjct: 282 --FKCHSGE-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYEC 338
Query: 2689 -CPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKH--WICDGEDDC 2745
CP G ++ Q+ CED DE +CS Q C++ + C E+
Sbjct: 339 LCPDGFQLV------AQRRCED-IDECQDPDTCS--------QLCVNLEGGYKCQCEE-- 381
Query: 2746 GDGLDESDSICGAITCAADMF 2766
G LD C A+ A +F
Sbjct: 382 GFQLDPHTKACKAVGSIAYLF 402
Score = 101 bits (252), Expect = 1e-20
Identities = 67/228 (29%), Positives = 95/228 (41%), Gaps = 21/228 (9%)
Query: 3671 GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRC--RNNRI 3728
G+ C +EF C + C + WVCDG +C D SDE+ + C+ C S C R NR
Sbjct: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKS-GDFSCGGRVNR- 81
Query: 3729 CLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCG 3788
C+ C+G +C + SDE C K C +DEF C + KCI CD DC
Sbjct: 82 CIPQFWRCDGQVDCDNGSDEQGCPPK------TCSQDEFRCHDGKCISRQFVCDSDRDCL 135
Query: 3789 DGSDEQGCRI---APTEY-----TCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR 3840
DGSDE C + P + TC + C +D C RC+ + +
Sbjct: 136 DGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
Query: 3841 QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQ 3888
C + G C H +G C ++ + N +A D+
Sbjct: 196 PCSAFEFHCLSGECIHSSWRCDGGPDC---KDKSDEENCAVATCRPDE 240
Score = 67.8 bits (164), Expect = 2e-10
Identities = 46/162 (28%), Positives = 70/162 (43%), Gaps = 21/162 (12%)
Query: 17 IARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK 76
+A +L C+ EF C D C+S W+CDG +C D SDES +TC + +
Sbjct: 12 VALLLAAAGTAVGDRCERNEFQCQDG-KCISYKWVCDGSAECQDGSDESQETC---LSVT 67
Query: 77 CPLNHIACLG-TNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMV 132
C +C G N+C+ C+G +DC +G DE C C +++C
Sbjct: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDE--------QGCPPKTCSQDEFRCHDG 119
Query: 133 RNSTRCYCEDGFEITEDGRSCKDQDECAVY--GTCSQTCRNT 172
+ +R + D DG D+ C V G S C ++
Sbjct: 120 KCISRQFVCDSDRDCLDG---SDEASCPVLTCGPASFQCNSS 158
Score = 37.0 bits (84), Expect = 0.45
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACAD 822
+P K+ G N C NNGGCS +C + G C C D
Sbjct: 308 EPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
Score = 33.9 bits (76), Expect = 3.8
Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 8/106 (7%)
Query: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHIC---KAG- 848
+G N + ++G C TL R C ++ + E GT + H+C K G
Sbjct: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGY 336
Query: 849 EFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQ 894
E C + + A+ +C+ D+C D D S C N + +KCQ
Sbjct: 337 ECLCPDGFQLVAQRRCEDIDECQD-PDTCSQLCVN---LEGGYKCQ 378
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 438 bits (1126), Expect = e-122
Identities = 280/823 (34%), Positives = 398/823 (48%), Gaps = 89/823 (10%)
Query: 3010 LSDEEPFLILADHHEIRKIS-TDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGS 3068
L++E F++ A I + G+ L GL +A+DFDY +YW D +
Sbjct: 754 LAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLAL---D 810
Query: 3069 RINRMCLNGSD-IKVVHNTAVPN--ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP-TIL 3124
I R+CLNGS +V+ N+ + ALA + + + LYW D + IEV+ +G + TI+
Sbjct: 811 VIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
Query: 3125 VSKRLKFPRDLSLDPQAGYLYWIDCCEY-PHIGRVGMDGTNQSVVIETKISRPMALTIDY 3183
S L PR L L PQ G ++W D + P I R MDG+ ++ + P +++D
Sbjct: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
Query: 3184 VNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAH 3241
++ +YW D IE G R + + ++P A+ +F++ IYW D S+ RA
Sbjct: 930 -DQWIYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987
Query: 3242 KTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 3301
K SG+ L + D++++ Y+ + + C+ CS LCL + +C CP
Sbjct: 988 KYSGSQMEILANQLTGLMDMKIF--YKGKNTGSNACVPRP--CSLLCLPKANNSRSCRCP 1043
Query: 3302 TNFYLAA----------------DNRTCL---SNCTASQFRCKTDKCIPFWWKCDTVDDC 3342
+ + N TC+ + C +Q+RC CI W CD +DC
Sbjct: 1044 EDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDC 1103
Query: 3343 GDGSDEPDDCPEFRCQ-PGRFQCG-TGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQ 3400
GD SDE + CP C +F+C +G C ++ CD E+DCGDNSDE +C+ H C S +
Sbjct: 1104 GDMSDERN-CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDE 1162
Query: 3401 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPE--NSCSPDYFQCKTTKHCISKLWVCDE 3458
+ C+ CI + C+G +DC D DE +C ++C FQC+ HCI + W CD
Sbjct: 1163 YNCSSGM-CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG-HCIPQRWACDG 1220
Query: 3459 DPDCADASDE--ANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCT 3516
D DC D SDE NC+KK G F+C N CIP CD DCSD SDE++C+P
Sbjct: 1221 DTDCQDGSDEDPVNCEKKCNG---FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTH 1277
Query: 3517 LKDFLCANGD-CVSSRFWCDGDFDCADGSDERNCETSCSKDQ----------FRCSNGQC 3565
DF+C N C+ CDG C DGSDE CS+D F+C NG C
Sbjct: 1278 FMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVC 1337
Query: 3566 IPAKWKCDGHEDCKYGEDEKSCE--PASPTCSSR-EYICASDGCISASLKCNGEYDCADG 3622
I WKCDG +DC DE +CE +P CS ++ C + CI KC+ E DC D
Sbjct: 1338 ISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDW 1397
Query: 3623 SDEMDC------------VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERG 3670
SDE DC + C + +RC + C+ W+CDG DC DGSDEE C
Sbjct: 1398 SDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGT-CVMDTWVCDGYRDCADGSDEEACPLL 1456
Query: 3671 GNI-----------CRADEFLCNNSLCKLHFWV-CDGEDDCGDNSDEAPDMCVKFLCPST 3718
N+ C EF C+ + W CDG DC D DEA L +
Sbjct: 1457 ANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMS 1516
Query: 3719 RPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLT-YKAR 3760
R +C + C+ + C+G +C D SDE C +LT YK +
Sbjct: 1517 REFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQ 1559
Score = 389 bits (998), Expect = e-107
Identities = 264/819 (32%), Positives = 370/819 (45%), Gaps = 128/819 (15%)
Query: 2225 IALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVG--SVEGLAYHRAWDT 2282
+AL FDY N +++SD IQ + N Q ++ N G +VE LA+
Sbjct: 791 VALDFDYEH-----NCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQL 845
Query: 2283 LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHP 2342
LYW + I + P R ++ S D P L L + +MFWT+W + P
Sbjct: 846 LYWVDAGFKKI-----EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
Query: 2343 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 2402
I RS + G A +VS D+ PNG+++D + +Y++D L IER + G QR VI+
Sbjct: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD 958
Query: 2403 SGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPH-QPMGIIAVANDT- 2460
+ P + ++AV+ N I+W DW + +I R++KY+G +IL + + M I +T
Sbjct: 959 NLPHPY-AIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTG 1017
Query: 2461 -NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECG 2519
N+C PC+LL CL N +C C D + + + + C+ ++
Sbjct: 1018 SNACVPRPCSLL-------CLPKANNSRSCRCPED---VSSSVLPSGDLMCDCPQGYQLK 1067
Query: 2520 NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGD 2579
N C+ E +C R C N CI CD +NDCGD
Sbjct: 1068 NNTCVK----------------------EENTCLRNQYRCSNGNCINSIWWCDFDNDCGD 1105
Query: 2580 NSDELDCKVSTC-ATVEFRCAD-GTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLG 2637
SDE +C + C +FRC + GTCIP S +C+ DC D SDE +C C
Sbjct: 1106 MSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCR------ 1159
Query: 2638 VKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILN 2697
+ C+S +C+ +W+CDG NDC D+SDE C H CE + F C +G CI
Sbjct: 1160 ---SDEYNCSS-GMCIRSSWVCDGDNDCRDWSDEANCTAIY-HTCEASNFQCRNGHCIPQ 1214
Query: 2698 TWICDGQKDCEDGRDE--FHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI 2755
W CDG DC+DG DE +C+ C N F C CI CDG DC DG DE
Sbjct: 1215 RWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH-- 1270
Query: 2756 CGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP----NNTCDENAF 2810
C + F C+ + C+ +CDG C DGSDE + AGC+ + CDE F
Sbjct: 1271 CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGF 1330
Query: 2811 MCHNKVCIPKQFVCDHDDDCGDGSD--------ESPQCG-YRQCGTEEFSCADGRCLLNT 2861
C N VCI + CD DDCGD SD E+P C Y Q F C +G C+ N
Sbjct: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQ-----FRCENGHCIPN- 1384
Query: 2862 QWQCDGDFDCPDHSDE-----APLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDC 2916
+W+CD + DC D SDE + + P +C +++ C +G C+ +CD DC
Sbjct: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
Query: 2917 GDGSDERNCHI--------------------NECLSKKV-----SGCS--QDCQD----- 2944
DGSDE C + EC K C QDCQD
Sbjct: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504
Query: 2945 -LPVSYKCKCWPGFQLKDDGKTCVDIDECSSGF-PCSQQ 2981
P C +DG+ C+ + E GF CS +
Sbjct: 1505 NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
Score = 351 bits (901), Expect = 8e-96
Identities = 220/636 (34%), Positives = 316/636 (49%), Gaps = 77/636 (12%)
Query: 550 IPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETILKDDLDNVEGIAVDW 608
+P+ L ALDF E N +Y++D +I R ++G T +E I+ L+ VE +A +
Sbjct: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
Query: 609 IGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTDWEED 667
+ LYW + G +K I VA + R T++ + PR +V+ P G M+WTDW
Sbjct: 842 LSQLLYWVDAGFKK-IEVANPD--GDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDW--- 895
Query: 668 EIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGT 727
D I ++ MDG V+ + WPNG+++D +YW DAY + IE++ +G
Sbjct: 896 --GDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQ 951
Query: 728 HRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQI 786
R ++ L HP+ ++ N ++W D+ SIF+ + S++ +L ++ L ++I
Sbjct: 952 QRSVILDN--LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKI 1009
Query: 787 YDPRKQQGDNMCRVNNGGCSTLCLA-IPGGRVCACADNQLLDENGTTCTFNPGEALPHIC 845
+ K G N C CS LCL R C C ++ + + P L C
Sbjct: 1010 FYKGKNTGSNACVPRP--CSLLCLPKANNSRSCRCPED-------VSSSVLPSGDLMCDC 1060
Query: 846 KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLC 905
G ++ KN C++ ++C +Q++C N CI W C
Sbjct: 1061 PQG-YQLKNNTCVKEE----------------------NTCLRNQYRCSNGNCINSIWWC 1097
Query: 906 DGANDCGSNEDESNQTCTARTCQVD-QFSC-GNGRCIPRAWLCDREDDCGDQTDEMASCE 963
D NDCG DE N C C +D QF C +G CIP ++ CD EDDCGD +DE + CE
Sbjct: 1098 DFDNDCGDMSDERN--CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDE-SHCE 1154
Query: 964 FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCV---HSCFDNQFRCSSGRCIP 1020
C ++ C SG CI S W CD D+DC D SDE C H+C + F+C +G CIP
Sbjct: 1155 MHQCRS-DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIP 1213
Query: 1021 GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
WACDGD DC D SDE +NC K+ CNG F+C P+G C+P CDG +DC
Sbjct: 1214 QRWACDGDTDCQDGSDEDPVNCEKK-------CNG--FRC-PNGTCIPSSKHCDGLRDCS 1263
Query: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
DGSDE+ C LC H F C + +C+ + VCDG I C D SDED + P+
Sbjct: 1264 DGSDEQHCE---PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE 1320
Query: 1141 -HPCAND------TSVCLQPEKLCNGKKDCPDGSDE 1169
H ++ VC+ C+G DC D SDE
Sbjct: 1321 FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Score = 257 bits (657), Expect = 2e-67
Identities = 152/409 (37%), Positives = 186/409 (45%), Gaps = 80/409 (19%)
Query: 796 NMCRVNNGGCSTLCLAIPGGRVCACADNQLLD-ENGTTCTFNPGEALPHICKAGEFRCKN 854
+ CR + CS+ + I VC DN D + CT A+ H C+A F+C+N
Sbjct: 1156 HQCRSDEYNCSS-GMCIRSSWVCD-GDNDCRDWSDEANCT-----AIYHTCEASNFQCRN 1208
Query: 855 RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDC--G 912
HCI RW CDGD DC DGSDED VNC C + F+C N CIP CDG DC G
Sbjct: 1209 GHCIPQRWACDGDTDCQDGSDEDPVNC-EKKC--NGFRCPNGTCIPSSKHCDGLRDCSDG 1265
Query: 913 SNEDESNQTCT---------------------------------------------ARTC 927
S+E CT + C
Sbjct: 1266 SDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVC 1325
Query: 928 QVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT----CEPLTQFVCKSGRCISS 983
F C NG CI W CD DDCGD +DE A+CE PT C QF C++G CI +
Sbjct: 1326 DEFGFQCQNGVCISLIWKCDGMDDCGDYSDE-ANCENPTEAPNCSRYFQFRCENGHCIPN 1384
Query: 984 KWHCDSDDDCGDGSDEVGCVHS------------CFDNQFRCSSGRCIPGHWACDGDNDC 1031
+W CD ++DCGD SDE C S C N +RCSSG C+ W CDG DC
Sbjct: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
Query: 1032 GDFSDEAQ----INCTKEEIHSPAG-CNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEK 1086
D SDE N T + G C+ EF+CH C+P+ RCDG +DC+DG DE
Sbjct: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504
Query: 1087 GCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFL 1135
C L +F C CI + CDG +DC D+SDE C L
Sbjct: 1505 NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDEL 1553
Score = 248 bits (632), Expect = 1e-64
Identities = 149/446 (33%), Positives = 207/446 (46%), Gaps = 69/446 (15%)
Query: 843 HICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKR 902
H C++ E+ C + CI++ W CDGD+DC D SDE + H+C F+C+N CIP+R
Sbjct: 1156 HQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQR 1215
Query: 903 WLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASC 962
W CDG DC DE C + + F C NG CIP + CD DC D +DE C
Sbjct: 1216 WACDGDTDCQDGSDEDPVNCEKK---CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQ-HC 1271
Query: 963 EFPTCEPLTQFVCKS-GRCISSKWHCDSDDDCGDGSDE----VGCVHS------CFDNQF 1011
E P C FVCK+ +C+ CD C DGSDE GC C + F
Sbjct: 1272 E-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGF 1330
Query: 1012 RCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLW 1071
+C +G CI W CDG +DCGD+SDEA NC + +P +F+C +G+C+P+ W
Sbjct: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCE-NGHCIPNRW 1386
Query: 1072 RCDGEKDCEDGSDEKGCNGTIRLCDHKTK---------FSCWSTGRCINKAWVCDGDIDC 1122
+CD E DC D SDEK C G + T + C S+G C+ WVCDG DC
Sbjct: 1387 KCDRENDCGDWSDEKDC-GDSHILPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDGYRDC 1444
Query: 1123 EDQSDEDDCDSFL-------------CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
D SDE+ C C + C + C+ K C+G +DC DG DE
Sbjct: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFEC-HQPKTCIPNWKRCDGHQDCQDGRDE 1503
Query: 1170 GYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV-DYCSNHLKCSQVC 1228
C H ++ +C +D + C ++ + C L CS
Sbjct: 1504 -----------ANCPTHSTL--------TCMSREFQCEDGEACIVLSERCDGFLDCSDES 1544
Query: 1229 EQHKHTVKCSCYE----GWKLDVDGE 1250
++ + + + Y+ W D G+
Sbjct: 1545 DEKACSDELTVYKVQNLQWTADFSGD 1570
Score = 179 bits (455), Expect = 4e-44
Identities = 101/300 (33%), Positives = 166/300 (55%), Gaps = 19/300 (6%)
Query: 1261 FIIFSIRHEIRRIDLHK-RDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319
FI++++R I R DL L + GLR +ALDF + + LYW+D+ D I R L+
Sbjct: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNG 819
Query: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLI-AGAME 1378
S G EV++ GL T E L + ++ +YW+D+ +IEVA DG R T++ + ++
Sbjct: 820 STGQ---EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 1379 HPRAIALDPRYGILFWTDWDANFPRIESASMSG-AGRKTIYKDMKTGAWPNGLTVDHFEK 1437
PRA+ L P+ G++FWTDW P I ++M G A + +D+K WPNG++VD ++
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK---WPNGISVD--DQ 931
Query: 1438 RIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANK 1497
I WTDA + I + G I+ + L HP+A++++ +E+YW DW ++ +A+K
Sbjct: 932 WIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 1498 WTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACP 1557
++G + ++ D++I++ + N C PCS +CL N S +C CP
Sbjct: 989 YSGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR----PCSLLCLPKANNSRSCRCP 1043
Score = 171 bits (432), Expect = 2e-41
Identities = 107/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 1880 FLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISR-AK 1938
F++Y+V + I L + +P++G AV +DF E++ +YW+D+ + I R
Sbjct: 760 FILYAVRKSIYRYDL--ASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
Query: 1939 RDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVII-SQGLDQ 1997
T +E II +GL VE +A + ++ +YW D GF IEVA +G FR I+ S LD+
Sbjct: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDR 877
Query: 1998 PRSIAVHPEKGLLFWTEWGQM-PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYW 2056
PR++ + P++G++FWT+WG + P I ++ +DGS LVS + WPNGIS+D + +YW
Sbjct: 878 PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYW 935
Query: 2057 CDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDA 2116
DA + IERI G + V+ + +++AVF IYW D + S+ R K
Sbjct: 936 TDAYLECIERITF--SGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQL--SIFRASKYSG 991
Query: 2117 TETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCAC----AH 2172
++ + L L ++KIF + + G+N C C LCL + N+ R+C C +
Sbjct: 992 SQMEILANQL-TGLMDMKIFYKGKNTGSNACV--PRPCSLLCLPKANNSRSCRCPEDVSS 1048
Query: 2173 GYLAEDGVTCLRHEGYLL 2190
L + C +GY L
Sbjct: 1049 SVLPSGDLMCDCPQGYQL 1066
Score = 145 bits (367), Expect = 7e-34
Identities = 107/319 (33%), Positives = 144/319 (45%), Gaps = 62/319 (19%)
Query: 935 GNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCG 994
G+ C+PR C C + + SC P E ++ V SG D DC
Sbjct: 1017 GSNACVPRP--CSLL--CLPKANNSRSCRCP--EDVSSSVLPSG---------DLMCDCP 1061
Query: 995 DGSDEVG--CV---HSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHS 1049
G CV ++C NQ+RCS+G CI W CD DNDCGD SDE T ++ +
Sbjct: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDT 1121
Query: 1050 PAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRC 1109
+F+C G C+P ++CD E DC D SDE C + C +++C S+G C
Sbjct: 1122 -------QFRCQESGTCIPLSYKCDLEDDCGDNSDESHCE--MHQC-RSDEYNC-SSGMC 1170
Query: 1110 INKAWVCDGDIDCEDQSDEDDCDSF--LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGS 1167
I +WVCDGD DC D SDE +C + C C N C+ C+G DC DGS
Sbjct: 1171 IRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN--GHCIPQRWACDGDTDCQDGS 1228
Query: 1168 DEGYL-----CDECSLNNGGC---SNHCSVVPGRGIVCSCPEGLQLNKDNKTCE-----I 1214
DE + C+ NG C S HC + C +G D + CE
Sbjct: 1229 DEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR------DCSDG----SDEQHCEPLCTHF 1278
Query: 1215 VDY-CSNHLKC---SQVCE 1229
+D+ C N +C S VC+
Sbjct: 1279 MDFVCKNRQQCLFHSMVCD 1297
Score = 138 bits (347), Expect = 1e-31
Identities = 88/299 (29%), Positives = 150/299 (50%), Gaps = 20/299 (6%)
Query: 1571 EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 1630
E +F+LYA R I D+ + + + +DFD LYW+D+ I
Sbjct: 756 EENEFILYAVRKSIYRYDLAS---GATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVI 812
Query: 1631 KRAFING-TGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII 1689
+R +NG TG E +I+ ++++ LA + +S+ LYW+ + F + I VA DG + +I+
Sbjct: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKK--IEVANPDGDFRLTIV 870
Query: 1690 HG--IDKPQCLAAHPVRGKLYWTDGNTIN----MANMDGSNS-KILFQNQKEPVGLSIDY 1742
+ +D+P+ L P G ++WTD + +NMDGS + ++ ++ K P G+S+D
Sbjct: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
Query: 1743 VENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGT 1802
+ +YW + I R G VI + L A+ + +++W D + +
Sbjct: 930 -DQWIYWTDAYLECIERITFSGQQRSVI---LDNLPHPYAIAVFKNEIYWDDWSQLSIFR 985
Query: 1803 CSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMC 1861
SK G IL N+ +G++ MK++ K GSN+C CS LCLP + +R+C C
Sbjct: 986 ASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRC 1042
Score = 103 bits (256), Expect = 5e-21
Identities = 111/414 (26%), Positives = 167/414 (40%), Gaps = 68/414 (16%)
Query: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGD-HSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYF 4081
+++ P A+ + P+ G+M+WT GD I + MDG+ LV ++++ P G++VD
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 4082 SERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRV 4140
+ IYW D L I + + G V + + L HP+ I +F++ IY + +FR
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Query: 4141 QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGA-TCVCPEG 4199
K+ +E LA + + I ++ K N C+ C LCL + + +C CPE
Sbjct: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKNTG-SNACVPRPCSLLCLPKANNSRSCRCPED 1045
Query: 4200 KYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSY--SGERC--EVNHC-- 4253
S+L GDL C C Y C E N C
Sbjct: 1046 V--------SSSVL-----------------PSGDLMCDCPQGYQLKNNTCVKEENTCLR 1080
Query: 4254 SNYCQNGGTCVPSVLGRP-TCSCALGFTGPNCGKTVCE---DF-CQNGGTCIVTA----- 4303
+ Y + G C+ S+ C NC T+C+ F CQ GTCI +
Sbjct: 1081 NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL 1140
Query: 4304 -----GNQPYCHCQPEYTGDRCQYYVCHH-YCVNSESCTIGD----DGSVECVCPTRYEG 4353
N HC+ R Y C C+ S GD D S E C Y
Sbjct: 1141 EDDCGDNSDESHCEMHQC--RSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYH- 1197
Query: 4354 PKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIAS--SCQ-LCDGYCYNGGTC 4404
CE +C GHCI + + D +C +G +C+ C+G+ GTC
Sbjct: 1198 -TCEASN-FQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTC 1249
Score = 97.4 bits (241), Expect = 3e-19
Identities = 69/269 (25%), Positives = 135/269 (50%), Gaps = 22/269 (8%)
Query: 238 LDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNL 297
LDF Y + + W + Q C+ G E IN V+ +A + L++ L
Sbjct: 793 LDFDYEHNCLYWSDLALDVIQRLCLN----GSTGQEVIIN--SGLETVEALAFEPLSQLL 846
Query: 298 YFVDHVGDRIFVCNSNGSVCVTLIDLE-LHNPKAIAVDPIAGKLFFTDYGNVAK-VERCD 355
Y+VD +I V N +G +T+++ L P+A+ + P G +F+TD+G++ + R +
Sbjct: 847 YWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSN 906
Query: 356 MDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRH 415
MDG ++ + P +++D ++ +YW D YL+ + + + G+ R ++ + H
Sbjct: 907 MDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD--NLPH 962
Query: 416 LYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRTQPTVRSHA 474
Y I VF++ +Y + +I R ++++G+ + L ++ ++I+ K S+A
Sbjct: 963 PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK--GKNTGSNA 1020
Query: 475 CEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
C +P CS +CL ++ +R+CRC
Sbjct: 1021 C------VPRPCSLLCLPKAN-NSRSCRC 1042
Score = 72.8 bits (177), Expect = 7e-12
Identities = 48/136 (35%), Positives = 63/136 (46%), Gaps = 17/136 (12%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C+ F C + C+ Q W CDGD DC D SDE P E KC N C C+
Sbjct: 1199 CEASNFQCRNG-HCIPQRWACDGDTDCQDGSDED----PVNCEKKC--NGFRC-PNGTCI 1250
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
S+ C+G+ DC DG DE HC+ L ++ C+ + + +S C DG DG
Sbjct: 1251 PSSKHCDGLRDCSDGSDE-QHCEPLCTHFMDFVCKNRQQCLFHSMVC---DGIIQCRDG- 1305
Query: 152 SCKDQDECAVYGTCSQ 167
DE A + CSQ
Sbjct: 1306 ----SDEDAAFAGCSQ 1317
Score = 66.6 bits (161), Expect = 5e-10
Identities = 35/100 (35%), Positives = 42/100 (42%), Gaps = 2/100 (2%)
Query: 17 IARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK 76
+A V CD EF CH TC+ CDG DC D DE+ CP +
Sbjct: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA--NCPTHSTLT 1513
Query: 77 CPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQEL 116
C C C+ LS+ C+G LDC D DE EL
Sbjct: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDEL 1553
Score = 63.9 bits (154), Expect = 3e-09
Identities = 48/152 (31%), Positives = 68/152 (44%), Gaps = 19/152 (12%)
Query: 27 RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLN-HIACL 85
+++ C ++ C + C++ W CD D DC D SDE CP + C L+ C
Sbjct: 1073 KEENTCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDER--NCPTTI---CDLDTQFRCQ 1126
Query: 86 GTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFE 145
+ C+ LS C+ DC D DE HC+ + NC +R+S C DG
Sbjct: 1127 ESGTCIPLSYKCDLEDDCGDNSDES-HCEMHQCRSDEYNCS-SGMCIRSSWVC---DG-- 1179
Query: 146 ITEDGRSCKDQDEC-AVYGTCSQT---CRNTH 173
D R D+ C A+Y TC + CRN H
Sbjct: 1180 -DNDCRDWSDEANCTAIYHTCEASNFQCRNGH 1210
Score = 56.6 bits (135), Expect = 6e-07
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 21/159 (13%)
Query: 31 LCD-PGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNK 89
+CD +F C + TC+ S+ CD + DC D+SDES C +C + C +
Sbjct: 1116 ICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDES--HCEMH---QCRSDEYNC-SSGM 1169
Query: 90 CVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYK---CTMVRNST--RCYCEDGF 144
C+ S +C+G DC D DE +C + C+ N Q + C R + C+DG
Sbjct: 1170 CIRSSWVCDGDNDCRDWSDE-ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGS 1228
Query: 145 EITEDGRSCKDQDECAVY----GTCSQTCRNTHGSYTCS 179
+ ED +C + +C + GTC + ++ G CS
Sbjct: 1229 D--EDPVNC--EKKCNGFRCPNGTCIPSSKHCDGLRDCS 1263
Score = 56.6 bits (135), Expect = 6e-07
Identities = 37/122 (30%), Positives = 47/122 (38%), Gaps = 26/122 (21%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEI----------KCPLNH 81
C P + C TCV +W+CDG DC D SDE + CP + +C
Sbjct: 1419 CLPNYYRCSSG-TCVMDTWVCDGYRDCADGSDE--EACPLLANVTAASTPTQLGRCDRFE 1475
Query: 82 IACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCE 141
C C+ + C+G DC DG DE NC T+ S CE
Sbjct: 1476 FECHQPKTCIPNWKRCDGHQDCQDGRDEA-------------NCPTHSTLTCMSREFQCE 1522
Query: 142 DG 143
DG
Sbjct: 1523 DG 1524
Score = 48.1 bits (113), Expect = 2e-04
Identities = 59/272 (21%), Positives = 93/272 (34%), Gaps = 78/272 (28%)
Query: 30 QLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES-------LDTCPEEVEIKCPLNHI 82
++CD F C + V C+S W CDG DC D SDE+ C + +C H
Sbjct: 1323 KVCDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHC 1381
Query: 83 ------------------------------------ACL------GTNKCVHLSQLCNGV 100
CL + CV + +C+G
Sbjct: 1382 IPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGY 1441
Query: 101 LDCPDGYDE----------GVHCQELLSNCQ--QLNCQYKCTMVRNSTRCYCEDGFEITE 148
DC DG DE L C + C T + N RC DG + +
Sbjct: 1442 RDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRC---DGHQDCQ 1498
Query: 149 DGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCV------EGYL---MQPDNRSCKAKIEP 199
DGR D+ C + T + R +C+ +G+L + D ++C ++
Sbjct: 1499 DGR---DEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTV 1555
Query: 200 TDRPPILLIANFE-TIEVFYLNGSKMATLSSV 230
+ A+F + + ++ KM + S V
Sbjct: 1556 YKVQNLQWTADFSGDVTLTWMRPKKMPSASCV 1587
Score = 41.2 bits (95), Expect = 0.024
Identities = 64/277 (23%), Positives = 91/277 (32%), Gaps = 47/277 (16%)
Query: 4160 GVLISHRYKQLDLPNPCLDLACEFLCLLNP------SGATCVCPEGKYLINGT--CND-- 4209
G I YK DL + C D + E C ++ + ++ +C ++ +G C D
Sbjct: 1129 GTCIPLSYK-CDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
Query: 4210 DSLLDDSCKLTCE------NGGRCILNE---KGDLRCHCWPSYSGERCEVNHCSNYCQNG 4260
D + TCE G CI GD C CE C+ +
Sbjct: 1188 DEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE-KKCNGFRCPN 1246
Query: 4261 GTCVPSVLG----------------RPTCSCALGFTGPNCGKT-----VCEDF--CQNGG 4297
GTC+PS P C+ + F N + VC+ C++G
Sbjct: 1247 GTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGS 1306
Query: 4298 ---TCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGP 4354
P H + G +CQ VC + D S E C E P
Sbjct: 1307 DEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAP 1366
Query: 4355 KCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSC 4391
C RC GHCI N+ D +C + C
Sbjct: 1367 NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Score = 38.1 bits (87), Expect = 0.20
Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 3/120 (2%)
Query: 2343 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQ-RHVIV 2401
SI R L + + T + L DY LY+SD +L I+R +GS + VI+
Sbjct: 768 SIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVII 827
Query: 2402 KSGPGTFLSLAV--YDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVAND 2459
SG T +LA ++W D G + I +N I+ S + +P ++ V +
Sbjct: 828 NSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQE 887
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 431 bits (1107), Expect = e-119
Identities = 233/643 (36%), Positives = 353/643 (54%), Gaps = 43/643 (6%)
Query: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
Query: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 94 D-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
Query: 1120 IDCEDQSDEDDCDSFL--CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE-GYL--CD 1174
DCE +DE C + L C + C + T C+ K CN ++DCPDGSDE G L +
Sbjct: 152 KDCEGGADEAGCATSLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLN 209
Query: 1175 ECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234
EC NNGGCS+ C+ + G C+CP G QL D KTC +D C + CSQ+C +K
Sbjct: 210 ECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGY 267
Query: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 1294
KC CY G+++D+ ++C + +IF+ RHE+RRIDL KR+YS L+P L+N +ALD
Sbjct: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 327
Query: 1295 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDS 1354
+ +YW D+ +IY + ++ EV+++ L +PEGL VDW+ +IYW DS
Sbjct: 328 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 387
Query: 1355 NLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGR 1414
I VA +DG R TL + + PRAIA+DP G ++W+DW + +IE + ++G R
Sbjct: 388 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDR 446
Query: 1415 KTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFA 1474
+T+ D WPNG+T+D +R+ W D++ + S + G N +I ++LSHPF
Sbjct: 447 QTLVSD--NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
Query: 1475 VSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN 1534
++++ +V+WTD + AN+ G +S++ + P D+ I+H +QP+AP+ C +
Sbjct: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
Query: 1535 -DGKGPCSHMCL-----INHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVD 1588
G C ++CL +H+ CACP M L D K CY R +
Sbjct: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY--------------RDAN 610
Query: 1589 IDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIK 1631
D+ + +TA + I + VI L W + K + K
Sbjct: 611 EDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK 653
Score = 353 bits (906), Expect = 2e-96
Identities = 198/572 (34%), Positives = 306/572 (53%), Gaps = 32/572 (5%)
Query: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 2820
C D F C+ R C+P W CD + DC D SDE P TC ++ F C N CI +
Sbjct: 47 CEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD----CPKKTCADSDFTCDNGHCIHE 101
Query: 2821 QFVCDHDDDCGDGSDESPQ-CGYRQCGTEEFSCA--DGRCLLNTQWQCDGDFDCPDHSDE 2877
++ CD +++C DGSDES C + C E+ SC +C+ W+CDG+ DC +DE
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV-PASWRCDGEKDCEGGADE 160
Query: 2878 APLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HINECLSKKV 2935
A C ++ +C F C +G C+ + C+ + DC DGSDE C +NECL
Sbjct: 161 AG----CATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN- 215
Query: 2936 SGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTD 2995
GCS C DL + ++C C GFQL D KTC DIDEC CSQ C+N G +KC C
Sbjct: 216 GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
Query: 2996 GYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREE 3055
GYE+ N CK+ + + P LI + HE+R+I NY+ L L NV+A+D +
Sbjct: 275 GYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATN 333
Query: 3056 FIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRIIE 3112
IYW D S R S + + +V+ + + P LAVDW+ K++YW+D+ + I
Sbjct: 334 RIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTIS 393
Query: 3113 VSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETK 3172
V+ ++G L S+ L PR +++DP G++YW D + I + G++G ++ ++
Sbjct: 394 VATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDN 453
Query: 3173 ISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALTLFEDYIY 3228
I P +T+D +++RLYW D + S++D G+ + + + D + + +FED ++
Sbjct: 454 IEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVF 513
Query: 3229 WTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMINNGGCSH 3286
WTD + +++ A++ +G + L + + DI ++H +QP + L + NGGC +
Sbjct: 514 WTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEY 573
Query: 3287 LCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
LCL AP +TCACP +L D + C
Sbjct: 574 LCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 295 bits (756), Expect = 5e-79
Identities = 181/592 (30%), Positives = 277/592 (46%), Gaps = 59/592 (9%)
Query: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
+C++DQF+C+N+ CIP W CD DC+D SDE++C + C +F C+N C
Sbjct: 46 DCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHER 102
Query: 3691 WVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
W CDGE++C D SDE+ C K +CP+ + + C+ + C+G +C +DE
Sbjct: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
Query: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
C L C+ DEF C + C+ C++ DC DGSDE GC E C N
Sbjct: 163 CATSLG----TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE--CLHNNG 216
Query: 3811 PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCD 3870
C C +K C C GFQ + + C D++EC CS C+N +G +KC C
Sbjct: 217 GCSH--ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECY 273
Query: 3871 QNFQER--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMD 3927
++ C A + L N ++ + NYS I + +D
Sbjct: 274 PGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALD 327
Query: 3928 VYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGN 3982
V + I W + Y++I+ +A+ LI + P +AVDWV +
Sbjct: 328 VEVATNRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 381
Query: 3983 IYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMY 4042
IYWTD +I+V ++G L + EP AIAV+P RG MY
Sbjct: 382 IYWTDSGNK---------------TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
Query: 4043 WTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDG 4102
W+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +L + S+ + G
Sbjct: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
Query: 4103 SNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGV 4161
N +SS L HP I +FED ++ +N +F + + LA N++ +
Sbjct: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Query: 4162 LISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202
+I H KQ P+ C + CE+LCL P + TC CP+ +L
Sbjct: 547 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 598
Score = 243 bits (621), Expect = 2e-63
Identities = 169/547 (30%), Positives = 259/547 (47%), Gaps = 65/547 (11%)
Query: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
Query: 86 GTN-KCVHLSQLCNG--------------------------------VL---------DC 103
T+ KCV S C+G VL DC
Sbjct: 136 PTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 195
Query: 104 PDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAV 161
PDG DE C + L+ C N C + CT ++ C C GF++ D ++C D DEC
Sbjct: 196 PDGSDEA-GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD 253
Query: 162 YGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNG 221
CSQ C N G + C C GY M ++CKA + P L+ N + L
Sbjct: 254 PDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTNRHEVRRIDLVK 310
Query: 222 SKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQS 281
+ L + N + LD + I W + S ++ + KA E + I +
Sbjct: 311 RNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD-PKEQEVLIDEQ 366
Query: 282 FHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLF 341
H+ + +A+DW+ +++Y+ D I V +G TL L P+AIAVDP+ G ++
Sbjct: 367 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
Query: 342 FTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQG 401
++D+G+ AK+E+ ++G++R ++ E P + LDL+++ +YWVD L + +D+ G
Sbjct: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
Query: 402 KNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGI 459
NR T+I + H +GI VFED ++ T+ +N I NR NG +I L + + N I
Sbjct: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
Query: 460 RIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRS 515
I+ + QP ACE+ GGC ++CL +SS TC C LG D +
Sbjct: 547 VIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKR 604
Query: 516 CKRPKNE 522
C R NE
Sbjct: 605 CYRDANE 611
Score = 184 bits (466), Expect = 2e-45
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 247 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 302
Query: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 303 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 358
Query: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 359 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 415
Query: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 416 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469
Query: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 470 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 529
Query: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 530 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589
Query: 818 CACADNQLLDENGTTC 833
CAC D L + C
Sbjct: 590 CACPDTMWLGPDMKRC 605
Score = 172 bits (437), Expect = 5e-42
Identities = 115/375 (30%), Positives = 190/375 (50%), Gaps = 27/375 (7%)
Query: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 257 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 314
Query: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 315 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 372
Query: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 373 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 432
Query: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 433 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 491
Query: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 492 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 548
Query: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLRH 2185
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 549 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRD 608
Query: 2186 EGYLLYSGRTILKSI 2200
G T+ ++
Sbjct: 609 ANEDSKMGSTVTAAV 623
Score = 169 bits (427), Expect = 8e-41
Identities = 75/187 (40%), Positives = 104/187 (55%), Gaps = 8/187 (4%)
Query: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
K C +FQC+N CIP WRCD +DC D+SDE++C +TC DF C NG C+ R+
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588
CDG+ +C DGSDE + C ++ C ++ +C+PA W+CDG +DC+ G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VTECKEDQFRCKNKAHC 3645
+ TC E+ C C+ A CN E DC DGSDE C + EC + C +
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
Query: 3646 IPIRWLC 3652
+ I + C
Sbjct: 225 LKIGFEC 231
Score = 165 bits (418), Expect = 8e-40
Identities = 76/177 (42%), Positives = 100/177 (56%), Gaps = 11/177 (6%)
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
C+ +F+C+N CI + W+CD DDDCLD SDED +C +C D F C N CI +RW
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
Query: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
CDG +C DES TCT + C ++ SCG + +C+P +W CD E DC DE A C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-AGC 163
Query: 963 --EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCFDNQFRCS 1014
TC +F C G C+ + HC+ + DC DGSDE GC ++ C N CS
Sbjct: 164 ATSLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
Score = 158 bits (399), Expect = 1e-37
Identities = 81/215 (37%), Positives = 107/215 (49%), Gaps = 16/215 (7%)
Query: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
P C D FQC+ + CI +W CDED DC D SDE +C KKTC +F C N +CI +
Sbjct: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Query: 3492 HWRCDSQNDCSDNSDEE--NCKPQTCTLKDFLC--ANGDCVSSRFWCDGDFDCADGSDER 3547
W+CD + +C D SDE C Q C + C + CV + + CDG+ DC G+DE
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3548 NCETS---CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD 3604
C TS C D+F+C +G C+ A C+ +DC G DE C C C+
Sbjct: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH- 220
Query: 3605 GCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
I LK E C G D+ C + ECK+
Sbjct: 221 --ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
Score = 136 bits (343), Expect = 4e-31
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 257 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 315
Query: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 316 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 371
Query: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 372 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 429
Query: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 430 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
Query: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 490 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 549
Query: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 550 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 134 bits (337), Expect = 2e-30
Identities = 65/161 (40%), Positives = 88/161 (54%), Gaps = 7/161 (4%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3433 EN--SCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 3471
+ +C D FQC C+ + C+++ DC D SDEA C
Sbjct: 165 TSLGTCRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGC 204
Score = 124 bits (311), Expect = 2e-27
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 252 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 309
Query: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
S + P KNV+AL + TNRI++ D + I D
Sbjct: 310 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 357
Query: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 358 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 412
Query: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 413 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 470
Query: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 471 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 528
Query: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 529 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 586
Query: 2486 RVNCSC 2491
+ C+C
Sbjct: 587 KYTCAC 592
Score = 122 bits (306), Expect = 8e-27
Identities = 77/252 (30%), Positives = 113/252 (44%), Gaps = 18/252 (7%)
Query: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
Query: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3470 NCDKK--TCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDC 3527
C TC EFQC + C+ C+ + DC D SDE C L + L NG C
Sbjct: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGC 218
Query: 3528 VSSRFWCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCK 3579
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 219 SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYE 277
Query: 3580 YGEDEKSCEPAS 3591
K+C+ A+
Sbjct: 278 MDLLTKNCKAAA 289
Score = 115 bits (288), Expect = 1e-24
Identities = 79/231 (34%), Positives = 102/231 (44%), Gaps = 18/231 (7%)
Query: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSAR 2609
+ C + C N RCIP CD ++DC D+SDE DC TCA +F C +G CI +
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 2610 CNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS-LCVLPTWICDGSNDCGDY 2668
C+ +C D SDE + CT V + C TS CV +W CDG DC
Sbjct: 105 CDGEEECPDGSDE---SEATCTK----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 2669 SDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC---DSSCSWNQF 2725
+DE C + C + F C G C+L C+ ++DC DG DE C + C N
Sbjct: 158 ADEAGC-ATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG 216
Query: 2726 ACSAQKCISKHWICDGEDDCGDGLDESD-SICGAITCAADMFSCQGSRACV 2775
CS I E C G D CG I D +C S+ CV
Sbjct: 217 GCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICV 262
Score = 107 bits (268), Expect = 2e-22
Identities = 76/229 (33%), Positives = 96/229 (41%), Gaps = 42/229 (18%)
Query: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
Query: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVS--TCATV 2594
SDE C + C C + +C+P CDGE DC +DE C S TC
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD 173
Query: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNC---------NNTDCTHF---YKLGVKTTG 2642
EF+C DGTC+ CNQ DC D SDE C NN C+H K+G + T
Sbjct: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECT- 232
Query: 2643 FIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKC--EENYFSC 2689
C + D CGD DE K P C + YF C
Sbjct: 233 ---------CPAGFQLLD-QKTCGDI-DECKDPDACSQICVNYKGYFKC 270
Score = 92.4 bits (228), Expect = 9e-18
Identities = 64/214 (29%), Positives = 87/214 (40%), Gaps = 30/214 (14%)
Query: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
+F+C N CI CD C D SDE C ++C C N CI CDGE
Sbjct: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWKCDGE 108
Query: 2575 NDCGDNSDELD--CKVSTCATVEFRCADGT--CIPRSARCNQNIDCADASDEKNCNNTDC 2630
+C D SDE + C C + C + C+P S RC+ DC +DE C +
Sbjct: 109 EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS-- 166
Query: 2631 THFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEEN----- 2685
LG +C CVL C+ DC D SDE C +Q ++C N
Sbjct: 167 -----LGTCRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGC-LQGLNECLHNNGGCS 219
Query: 2686 ----------YFSCPSGRCILNTWICDGQKDCED 2709
+CP+G +L+ C +C+D
Sbjct: 220 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
Score = 63.5 bits (153), Expect = 5e-09
Identities = 58/238 (24%), Positives = 86/238 (36%), Gaps = 47/238 (19%)
Query: 789 PRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAG 848
P+K D+ +NG C G C DE+ TCT +C A
Sbjct: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGS----DESEATCT-------KQVCPAE 130
Query: 849 EFRC--KNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCD 906
+ C + C+ A W+CDG+ DC G+DE +C D+F+C + C+ C+
Sbjct: 131 KLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCN 190
Query: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT 966
DC DE+ C + NG C + +C TD E
Sbjct: 191 QEQDCPDGSDEAGCLQGLNECLHN-----NGGC---SHIC---------TDLKIGFE--- 230
Query: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC--FDNQFRCSSGRCIPGH 1022
C +G + + C D+C D C C + F+C C PG+
Sbjct: 231 ------CTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKC---ECYPGY 276
Score = 55.8 bits (133), Expect = 9e-07
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818
A+ C+KD+F C N++CIP +CD DDC D SDE C + TC D+ C D+ +C
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
Query: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
+ K C G + + C E L G SH+C V S++C
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
Score = 41.6 bits (96), Expect = 0.018
Identities = 47/186 (25%), Positives = 69/186 (37%), Gaps = 51/186 (27%)
Query: 3273 SKHLCMINNGGC---SHLCLLAPGKTHTCACPTNFYLAADNRTC---LSNCTASQFRCKT 3326
+K +C C SH C+ A + C + AD C L C +F+C
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWR---CDGEKDCEGGADEAGCATSLGTCRGDEFQCGD 179
Query: 3327 DKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNS 3386
C+ C+ DC DGSDE A G N+C N+
Sbjct: 180 GTCVLAIKHCNQEQDCPDGSDE------------------------AGCLQGLNECLHNN 215
Query: 3387 DELNCDTHVC--LSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS------P 3438
C +H+C L F+CT P + Q CGD ++ +D ++CS
Sbjct: 216 G--GC-SHICTDLKIGFECT-----CPAGFQLLDQKTCGDIDECKD--PDACSQICVNYK 265
Query: 3439 DYFQCK 3444
YF+C+
Sbjct: 266 GYFKCE 271
Score = 39.7 bits (91), Expect = 0.070
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 261
Query: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 262 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 296
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 394 bits (1012), Expect = e-108
Identities = 205/577 (35%), Positives = 313/577 (54%), Gaps = 60/577 (10%)
Query: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
Query: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 94 -DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
Query: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLN 1179
DCE +DE C ++L +EC N
Sbjct: 152 KDCEGGADEAGCATWL--------------------------------------NECLHN 173
Query: 1180 NGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSC 1239
NGGCS+ C+ + G C+CP G QL D KTC +D C + CSQ+C +K KC C
Sbjct: 174 NGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCEC 231
Query: 1240 YEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQ 1299
Y G+++D+ ++C + +IF+ RHE+RRIDL KR+YS L+P L+N +ALD
Sbjct: 232 YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVAT 291
Query: 1300 SLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQI 1359
+ +YW D+ +IY + ++ EV+++ L +PEGL VDW+ +IYW DS I
Sbjct: 292 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 351
Query: 1360 EVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK 1419
VA +DG R TL + + PRAIA+DP G ++W+DW + +IE + ++G R+T+
Sbjct: 352 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDRQTLVS 410
Query: 1420 DMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYG 1479
D WPNG+T+D +R+ W D++ + S + G N +I ++LSHPF ++++
Sbjct: 411 D--NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFE 468
Query: 1480 SEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN-DGKG 1538
+V+WTD + AN+ G +S++ + P D+ I+H +QP+AP+ C + G
Sbjct: 469 DKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNG 528
Query: 1539 PCSHMCL-----INHNRSAACACPHLMKLSSDKKTCY 1570
C ++CL +H+ CACP M L D K CY
Sbjct: 529 GCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
Score = 337 bits (863), Expect = 2e-91
Identities = 183/534 (34%), Positives = 290/534 (54%), Gaps = 27/534 (5%)
Query: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857
G P C+++ F C N+ CIP + CD DDDC D SDE C + C +F+C +G C
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
Query: 2858 LLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMC--KNGRCIPSGGLCDNKDD 2915
+ + +W+CDG+ +CPD SDE+ + +Q C + C + +C+P+ CD + D
Sbjct: 99 I-HERWKCDGEEECPDGSDES----EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
Query: 2916 CGDGSDERNCH--INECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECS 2973
C G+DE C +NECL GCS C DL + ++C C GFQL D KTC DIDEC
Sbjct: 154 CEGGADEAGCATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECK 211
Query: 2974 SGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGS 3033
CSQ C+N G +KC C GYE+ N CK+ + + P LI + HE+R+I
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKR 270
Query: 3034 NYTLLKQGLNNVIAIDFDYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PN 3090
NY+ L L NV+A+D + IYW D S R S + + +V+ + + P
Sbjct: 271 NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
Query: 3091 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 3150
LAVDW+ K++YW+D+ + I V+ ++G L S+ L PR +++DP G++YW D
Sbjct: 331 GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 390
Query: 3151 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRH 3207
+ I + G++G ++ ++ I P +T+D +++RLYW D + S++D G+ +
Sbjct: 391 DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT 450
Query: 3208 KVPNQD-IPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHS 3266
+ + D + + +FED ++WTD + +++ A++ +G + L + + DI ++H
Sbjct: 451 LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHE 510
Query: 3267 YRQPDV--SKHLCMINNGGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
+QP + L + NGGC +LCL AP +TCACP +L D + C
Sbjct: 511 LKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 254 bits (648), Expect = 2e-66
Identities = 163/502 (32%), Positives = 252/502 (50%), Gaps = 24/502 (4%)
Query: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
Query: 86 GTN-KCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCED 142
T+ KCV S C+G DC G DE C L+ C N C + CT ++ C C
Sbjct: 136 PTSHKCVPASWRCDGEKDCEGGADEA-GCATWLNECLHNNGGCSHICTDLKIGFECTCPA 194
Query: 143 GFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDR 202
GF++ D ++C D DEC CSQ C N G + C C GY M ++CKA +
Sbjct: 195 GFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGK 250
Query: 203 PPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCI 262
P L+ N + L + L + N + LD + I W + S ++
Sbjct: 251 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSA 307
Query: 263 QITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLID 322
+ KA E + I + H+ + +A+DW+ +++Y+ D I V +G TL
Sbjct: 308 YMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 366
Query: 323 LELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNK 382
L P+AIAVDP+ G ++++D+G+ AK+E+ ++G++R ++ E P + LDL+++
Sbjct: 367 RNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQ 426
Query: 383 LVYWVDLYLDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINR 441
+YWVD L + +D+ G NR T+I + H +GI VFED ++ T+ +N I NR
Sbjct: 427 RLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR 486
Query: 442 FNGTDIHSLIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSY 496
NG +I L + + N I I+ + QP ACE+ GGC ++CL +SS
Sbjct: 487 LNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHS 544
Query: 497 KTRTCRCRTGFNLGSDGRSCKR 518
TC C LG D + C R
Sbjct: 545 PKYTCACPDTMWLGPDMKRCYR 566
Score = 249 bits (635), Expect = 6e-65
Identities = 165/592 (27%), Positives = 258/592 (43%), Gaps = 100/592 (16%)
Query: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
+C++DQF+C+N+ CIP W CD DC+D SDE++C + C +F C+N C
Sbjct: 46 DCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHER 102
Query: 3691 WVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
W CDGE++C D SDE+ C K +CP+ + + C+ + C+G +C +DE
Sbjct: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
Query: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
C L C + CS+
Sbjct: 163 CATWL----NECLHNNGGCSH--------------------------------------- 179
Query: 3811 PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCD 3870
C +K C C GFQ + + C D++EC CS C+N +G +KC C
Sbjct: 180 ------ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECY 232
Query: 3871 QNFQE--RNNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMD 3927
++ C A + L N ++ + NYS I + +D
Sbjct: 233 PGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALD 286
Query: 3928 VYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGN 3982
V + I W + Y++I+ +A+ LI + P +AVDWV +
Sbjct: 287 VEVATNRIYWC------DLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 340
Query: 3983 IYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMY 4042
IYWTD S +I+V ++G L + EP AIAV+P RG MY
Sbjct: 341 IYWTD---------------SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 385
Query: 4043 WTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDG 4102
W+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +L + S+ + G
Sbjct: 386 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 445
Query: 4103 SNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGV 4161
N +SS L HP I +FED ++ +N +F + + LA N++ +
Sbjct: 446 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 505
Query: 4162 LISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202
+I H KQ P+ C + CE+LCL P + TC CP+ +L
Sbjct: 506 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 557
Score = 184 bits (466), Expect = 2e-45
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 206 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 261
Query: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 262 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 317
Query: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 318 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 374
Query: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 375 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428
Query: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 429 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 488
Query: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 489 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548
Query: 818 CACADNQLLDENGTTC 833
CAC D L + C
Sbjct: 549 CACPDTMWLGPDMKRC 564
Score = 172 bits (435), Expect = 9e-42
Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)
Query: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 216 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 273
Query: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 274 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
Query: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
Query: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 450
Query: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 451 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 507
Query: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 508 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 566
Score = 137 bits (344), Expect = 3e-31
Identities = 66/171 (38%), Positives = 91/171 (53%), Gaps = 13/171 (7%)
Query: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
K C +FQC+N CIP WRCD +DC D+SDE++C +TC DF C NG C+ R+
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588
CDG+ +C DGSDE + C ++ C ++ +C+PA W+CDG +DC+ G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
C C+ I LK E C G D+ C + ECK+
Sbjct: 165 TWLNECLHNNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
Score = 136 bits (343), Expect = 4e-31
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 216 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 274
Query: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 275 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
Query: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 331 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 388
Query: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 389 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 448
Query: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 449 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 508
Query: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 509 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 134 bits (336), Expect = 3e-30
Identities = 68/197 (34%), Positives = 94/197 (47%), Gaps = 27/197 (13%)
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
C+ +F+C+N CI + W+CD DDDCLD SDED +C +C D F C N CI +RW
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
Query: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
CDG +C DES TCT + C ++ SCG + +C+P +W CD E DC DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 963 EF------------PTCEPLT---QFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC- 1006
+ C L + C +G + + C D+C D C C
Sbjct: 165 TWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICV 221
Query: 1007 -FDNQFRCSSGRCIPGH 1022
+ F+C C PG+
Sbjct: 222 NYKGYFKC---ECYPGY 235
Score = 124 bits (311), Expect = 2e-27
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 211 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 268
Query: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
S + P KNV+AL + TNRI++ D + I D
Sbjct: 269 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 316
Query: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 317 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 371
Query: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 372 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 429
Query: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 430 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 487
Query: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 488 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 545
Query: 2486 RVNCSC 2491
+ C+C
Sbjct: 546 KYTCAC 551
Score = 123 bits (309), Expect = 4e-27
Identities = 74/214 (34%), Positives = 98/214 (45%), Gaps = 23/214 (10%)
Query: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
P C D FQC+ + CI +W CDED DC D SDE +C KKTC +F C N +CI +
Sbjct: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Query: 3492 HWRCDSQNDCSDNSDEE--NCKPQTCTLKDFLC--ANGDCVSSRFWCDGDFDCADGSDER 3547
W+CD + +C D SDE C Q C + C + CV + + CDG+ DC G+DE
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3548 NCET---SCSKDQFRCSNGQCIPAKWKCDGHEDCKYG---EDEKSCEPASPTCSSREYIC 3601
C T C + CS+ I K C G D+K TC +
Sbjct: 162 GCATWLNECLHNNGGCSH---ICTDLKIGFECTCPAGFQLLDQK-------TCGDIDECK 211
Query: 3602 ASDGCISASLKCNGEYDC-ADGSDEMDCVTE-CK 3633
D C + G + C EMD +T+ CK
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCK 245
Score = 120 bits (301), Expect = 3e-26
Identities = 70/187 (37%), Positives = 90/187 (48%), Gaps = 27/187 (14%)
Query: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICD 2740
CE++ F C + RCI + W CD DC D DE C +C+ + F C CI + W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2741 GEDDCGDGLDESDSICGAITCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
GE++C DG DES++ C C A+ SC S CVP W CDGE+DC G+DE AGC
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
Query: 2800 AP-NNTCDENAFMCHNKVC----------------IPKQFVCDHDDDCGDGSDESPQC-- 2840
A N C N C + +C + Q C D+C D S C
Sbjct: 164 ATWLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN 222
Query: 2841 --GYRQC 2845
GY +C
Sbjct: 223 YKGYFKC 229
Score = 117 bits (294), Expect = 2e-25
Identities = 65/172 (37%), Positives = 87/172 (50%), Gaps = 17/172 (9%)
Query: 924 ARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISS 983
A+ C+ DQF C N RCIP W CD +DDC D +DE C TC + F C +G CI
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCAD-SDFTCDNGHCIHE 101
Query: 984 KWHCDSDDDCGDGSD--EVGCVHS-CFDNQFRC--SSGRCIPGHWACDGDNDCGDFSDEA 1038
+W CD +++C DGSD E C C + C +S +C+P W CDG+ DC +DEA
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 1039 Q-INCTKEEIHSPAGCN--------GNEFQCHPDGNCVPDLWRCDGEKDCED 1081
E +H+ GC+ G E C P G + D C +C+D
Sbjct: 162 GCATWLNECLHNNGGCSHICTDLKIGFECTC-PAGFQLLDQKTCGDIDECKD 212
Score = 114 bits (285), Expect = 2e-24
Identities = 69/208 (33%), Positives = 101/208 (48%), Gaps = 20/208 (9%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3433 E--NSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN--- 3487
N C + C H + L + E C + D+KTCG + +CK+ +
Sbjct: 165 TWLNECLHNNGGC---SHICTDLKIGFE---CTCPAGFQLLDQKTCGDID-ECKDPDACS 217
Query: 3488 --CI--PDHWRCDSQNDCSDNSDEENCK 3511
C+ +++C+ + +NCK
Sbjct: 218 QICVNYKGYFKCECYPGYEMDLLTKNCK 245
Score = 96.7 bits (239), Expect = 5e-19
Identities = 52/161 (32%), Positives = 74/161 (45%), Gaps = 12/161 (7%)
Query: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711
C+ W CD +DC D+SDE CP K C ++ F+C +G CI W CDG+++C DG
Sbjct: 59 CIPSVWRCDEDDDCLDHSDEDDCP---KKTCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
Query: 2712 DEFHCDSS---CSWNQFAC--SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
DE + C + +C ++ KC+ W CDGE DC G DE+ G T +
Sbjct: 116 DESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA----GCATWLNECL 171
Query: 2767 SCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDE 2807
G + + E CP G L C + C +
Sbjct: 172 HNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
Score = 92.0 bits (227), Expect = 1e-17
Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 22/175 (12%)
Query: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSAR 2609
+ C + C N RCIP CD ++DC D+SDE DC TCA +F C +G CI +
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 2610 CNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS-LCVLPTWICDGSNDCGDY 2668
C+ +C D SDE + CT V + C TS CV +W CDG DC
Sbjct: 105 CDGEEECPDGSDE---SEATCTK----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 2669 SDELKCP------VQN----KHKCEENYF----SCPSGRCILNTWICDGQKDCED 2709
+DE C + N H C + +CP+G +L+ C +C+D
Sbjct: 158 ADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
Score = 90.5 bits (223), Expect = 3e-17
Identities = 42/122 (34%), Positives = 60/122 (49%), Gaps = 4/122 (3%)
Query: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
Query: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3470 NC 3471
C
Sbjct: 162 GC 163
Score = 79.7 bits (195), Expect = 6e-14
Identities = 60/193 (31%), Positives = 76/193 (39%), Gaps = 32/193 (16%)
Query: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
+F+C N CI CD C D SDE C ++C C N CI CDGE
Sbjct: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWKCDGE 108
Query: 2575 NDCGDNSDELD--CKVSTCATVEFRCADGT--CIPRSARCNQNIDCADASDEKNC----- 2625
+C D SDE + C C + C + C+P S RC+ DC +DE C
Sbjct: 109 EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLN 168
Query: 2626 ----NNTDCTHF---YKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN 2678
NN C+H K+G + T C + D CGD DE K P
Sbjct: 169 ECLHNNGGCSHICTDLKIGFECT----------CPAGFQLLD-QKTCGDI-DECKDPDAC 216
Query: 2679 KHKC--EENYFSC 2689
C + YF C
Sbjct: 217 SQICVNYKGYFKC 229
Score = 64.3 bits (155), Expect = 3e-09
Identities = 55/199 (27%), Positives = 72/199 (36%), Gaps = 38/199 (19%)
Query: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
Query: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
SDE C + C C + +C+P CDGE DC +DE C
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWL------ 167
Query: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFI-RCNSTSLCVLP 2655
C+ + C+ C D C T F L KT G I C C
Sbjct: 168 ----NECLHNNGGCSH--ICTDLKIGFEC--TCPAGFQLLDQKTCGDIDECKDPDAC--- 216
Query: 2656 TWICDGSNDCGDYSDELKC 2674
S C +Y KC
Sbjct: 217 ------SQICVNYKGYFKC 229
Score = 39.7 bits (91), Expect = 0.070
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 220
Query: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 221 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 255
Score = 35.8 bits (81), Expect = 1.0
Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 5/63 (7%)
Query: 796 NMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KAGEF 850
N C NNGGCS +C + G C C A QLLD+ G +A IC G F
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 851 RCK 853
+C+
Sbjct: 228 KCE 230
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 227 bits (578), Expect = 2e-58
Identities = 138/406 (33%), Positives = 209/406 (51%), Gaps = 25/406 (6%)
Query: 2921 DERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQ 2980
D + CH + VS CS DC C C G L+ DGKTC +G CSQ
Sbjct: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNG-GCSQ 449
Query: 2981 QCINTYG-TYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY-TLL 3038
C+ +++C C GY++Q D + C + S +PFL+ A+ +IR + DG++Y TLL
Sbjct: 450 LCVPLSPVSWECDCFPGYDLQLDEKS-CAA-SGPQPFLLFANSQDIRHMHFDGTDYGTLL 507
Query: 3039 KQGLNNVIAIDFDYREEFIY-------WIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA 3091
Q + V A+D D E IY WI+ + +GS+ R+ G D VP
Sbjct: 508 SQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD--------VPEG 559
Query: 3092 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 3151
LAVDWIG+ YW+D K +I S LNG I+ + + PR +++ P A L+W D
Sbjct: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 3152 YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKV 3209
P I + G + V+ + + P +TID++ +LYW D ++ IE +N+DGS R ++
Sbjct: 620 NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRL 679
Query: 3210 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQ 3269
D+ A+ +FEDY++++D S+ R +K +G DR+ L S + + V H +
Sbjct: 680 TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAK 739
Query: 3270 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLS 3315
P C+ NGGC H+C G T C+C F A+D +TCL+
Sbjct: 740 PGADP--CLYQNGGCEHICKKRLG-TAWCSCREGFMKASDGKTCLA 782
Score = 214 bits (546), Expect = 1e-54
Identities = 128/371 (34%), Positives = 197/371 (53%), Gaps = 10/371 (2%)
Query: 1826 VYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC--QGIESFLMY 1883
V +++ + S +NGGCSQLC+P S + C C GY LQ + SC G + FL++
Sbjct: 428 VLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF 487
Query: 1884 SVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW 1943
+ + IR + + +D L G +A +D + IY+ I RA D +
Sbjct: 488 ANSQDIRHMHFDGTDYGTLLSQQMGMVYA--LDHDPVENKIYFAHTALKWIERANMDGSQ 545
Query: 1944 KEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAV 2003
+E +I G+ EG+AVDWI YWTD G +LI + LNG +I + + QPR IAV
Sbjct: 546 RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAV 605
Query: 2004 HPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDK 2063
HP LFWT+ G P I + L G ++V+ S + WP+GI+ID+ +KLYWCDA+
Sbjct: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
Query: 2064 IERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMR 2123
IE +L+ G R + F+VAVF Y+++SD A SV R +K + + ++
Sbjct: 666 IEMANLD-GSKRRRLTQNDVGHPFAVAVFEDYVWFSD--WAMPSVMRVNKRTGKDRVRLQ 722
Query: 2124 TGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYL-AEDGVTC 2182
G + + + + + + G + C NGGC+ +C R + C+C G++ A DG TC
Sbjct: 723 -GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGT-AWCSCREGFMKASDGKTC 780
Query: 2183 LRHEGYLLYSG 2193
L +G+ L +G
Sbjct: 781 LALDGHQLLAG 791
Score = 197 bits (500), Expect = 3e-49
Identities = 135/425 (31%), Positives = 204/425 (48%), Gaps = 24/425 (5%)
Query: 1163 CPDGS---DEGYLCDE---CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVD 1216
CP G +G C + C N CS+ C V+ G +C CPEG L +D KTC
Sbjct: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDC-VLTSEGPLCFCPEGSVLERDGKTCSGCS 440
Query: 1217 YCSNHLKCSQVCEQHKHTV-KCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDL 1275
N CSQ+C +C C+ G+ L +D +SC + P + F++F+ +IR +
Sbjct: 441 SPDNG-GCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGP-QPFLLFANSQDIRHMHF 498
Query: 1276 HKRDY-SLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 1334
DY +LL + ALD ++ +Y+ I R + S E ++E G+
Sbjct: 499 DGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR----ERLIEEGV 554
Query: 1335 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 1394
PEGL VDWI YW D I + L+G + + PR IA+ P LFW
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 1395 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 1454
TD N PRIES+S+ G GR I WP+G+T+D ++ W DA+ I A
Sbjct: 615 TDTGIN-PRIESSSLQGLGRLVIAS--SDLIWPSGITIDFLTDKLYWCDAKQSVIEMANL 671
Query: 1455 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 1514
DG+ + + + HPFAV+++ V+++DW ++ + NK TG++ +Q + +P
Sbjct: 672 DGSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
Query: 1515 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 1574
L + HP +P A +PC + G C H+C +A C+C +SD KTC +
Sbjct: 730 SLVVVHPLAKPGA-DPCLYQN--GGCEHICK-KRLGTAWCSCREGFMKASDGKTCLALDG 785
Query: 1575 FLLYA 1579
L A
Sbjct: 786 HQLLA 790
Score = 181 bits (458), Expect = 2e-44
Identities = 148/538 (27%), Positives = 240/538 (44%), Gaps = 68/538 (12%)
Query: 484 GGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTK 543
GGCS +C+ S C C G++L D +SC + FL + + +R M +
Sbjct: 445 GGCSQLCVPLSPVSWE-CDCFPGYDLQLDEKSCAASGPQPFLLFANSQD--IRHMHFDG- 500
Query: 544 IADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEG 603
D + + + ALD N IYFA T I R +DG++RE ++++ +D EG
Sbjct: 501 -TDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 604 IAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTD 663
+AVDWIG YWT+ G K++ + R + + K + + +S PRGI V P+ ++WTD
Sbjct: 560 LAVDWIGRRFYWTDRG--KSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTD 616
Query: 664 WEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVF 723
+ RIE + + G R + +S ++WP+G+T+DF T+ LYWCDA IE
Sbjct: 617 TGINP------RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Query: 724 LNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTL-LRHERPPLF 782
L+G+ R+ + + ++ HPF ++ +YV+++D+ S+ +++ T + + L+
Sbjct: 671 LDGSKRRRL-TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
Query: 783 GLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALP 842
L + P + G + C NGGC +C G C+C + + +G TC G L
Sbjct: 730 SLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQL- 788
Query: 843 HICKAGEFRCKNRHCIQARWKCDGDDDCLDGS--DEDSVNCFNHSCPDDQFKCQNNRCIP 900
GE KN+ D L + ED++ H + + C P
Sbjct: 789 --LAGGEVDLKNQVT---------PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAP 837
Query: 901 KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA 960
C C S +++ TCQ + G+G+ LC D+C EM
Sbjct: 838 VG--CSMYARCISEGEDA-------TCQCLKGFAGDGK------LCSDIDEC-----EMG 877
Query: 961 SCEFPTCEPLTQ--------FVCKSGRCISSKW-HCDSDDDCGDGSDEVGCVHSCFDN 1009
P C P + +VC+ HC D+C G HSC +N
Sbjct: 878 ---VPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGE------HSCGEN 926
Score = 160 bits (405), Expect = 3e-38
Identities = 125/482 (25%), Positives = 200/482 (41%), Gaps = 54/482 (11%)
Query: 58 CPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLC---------NGVLDCPDGY- 107
C D L C E + + C N+C + C + CP G+
Sbjct: 330 CGQDLQSHLCMCAEGYALSRDRKY--CEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFV 387
Query: 108 --DEGVHCQELLSNCQQLN-CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGT 164
+G C +L+S + ++ C + C + C+C +G + DG++C G
Sbjct: 388 LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS-PDNGG 446
Query: 165 CSQTCRNTHG-SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSK 223
CSQ C S+ C C GY +Q D +SC A + P LL AN + I + +G+
Sbjct: 447 CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA----SGPQPFLLFANSQDIRHMHFDGTD 502
Query: 224 MATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFH 283
TL S ++ LD E+ I + + LK I+ G E I +
Sbjct: 503 YGTLLSQQMGMVYALDHDPVENKIYFAHTA-----LKWIERANMDGSQRERLIE--EGVD 555
Query: 284 NVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFT 343
+ +A+DW+ R Y+ D I + NG + + P+ IAV P+A +LF+T
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 344 DYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKN 403
D G ++E + G+ R I S P+ + +D + +YW D + + + G
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 404 RHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQ 463
R + Q V H + + VFEDY++ ++ +++R+N+ G D +R+
Sbjct: 676 RRRLTQ-NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKD-----------RVRLQG 723
Query: 464 KRTQPTVRSHACEVDPYGMP---------GGCSHICLLSSSYKTRTCRCRTGFNLGSDGR 514
+P S V P P GGC HIC T C CR GF SDG+
Sbjct: 724 SMLKP---SSLVVVHPLAKPGADPCLYQNGGCEHIC--KKRLGTAWCSCREGFMKASDGK 778
Query: 515 SC 516
+C
Sbjct: 779 TC 780
Score = 140 bits (354), Expect = 2e-32
Identities = 176/727 (24%), Positives = 268/727 (36%), Gaps = 109/727 (14%)
Query: 3804 TCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEG 3863
+C NV+ C D C C C G + C + G CS C+ +
Sbjct: 400 SCPRNVSECSHD--CVLTSEGPLCFCPEGSVLERDGKTCSGCSSP-DNGGCSQLCVPLSP 456
Query: 3864 -SYKCVCDQNF--QERNNTCIAEGSEDQVLYIANDTDIL-----GFIYPFNYSGDHQQIS 3915
S++C C + Q +C A G + +L+ AN DI G Y S +
Sbjct: 457 VSWECDCFPGYDLQLDEKSCAASGPQPFLLF-ANSQDIRHMHFDGTDYGTLLSQQMGMVY 515
Query: 3916 HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIA 3975
++H+ +Y+ + W + N G + +R G+ PE +A
Sbjct: 516 ALDHDP--VENKIYFAHTALKWIERANMDG-------SQRERLIEEGVDVPE-----GLA 561
Query: 3976 VDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVN 4035
VDW+ YWTD + I LNG + +P IAV+
Sbjct: 562 VDWIGRRFYWTDRGKS---------------LIGRSDLNGKRSKIITKENISQPRGIAVH 606
Query: 4036 PKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSII 4095
P ++WT G + IE +++ G R ++ +L P+G+ +D+ ++++YW D + S+I
Sbjct: 607 PMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 4096 GSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYI-YGAGPKNGVFRVQKFGHGSVEYLALN 4154
DGS + G HP + +FEDY+ + V RV K L +
Sbjct: 667 EMANLDGSKRRRLTQNDVG--HPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGS 724
Query: 4155 IDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGATCVCPEG--KYLINGTC--- 4207
+ K +++ H + +PCL + CE +C A C C EG K TC
Sbjct: 725 MLKPSSLVVVHPLAKPG-ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLAL 783
Query: 4208 --------------NDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHC 4253
N + LD K I + L S + C C
Sbjct: 784 DGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN--ITESQHMLVAEIMVS-DQDDCAPVGC 840
Query: 4254 SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF--CQNG--------GTCIVTA 4303
S Y + C+ S TC C GF G GK +C D C+ G CI T
Sbjct: 841 SMYAR----CI-SEGEDATCQCLKGFAGD--GK-LCSDIDECEMGVPVCPPASSKCINTE 892
Query: 4304 GNQPYCHCQPEYTG--------DRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPK 4355
G C C Y G D CQ + H C + SCT +G C+C R P
Sbjct: 893 GGY-VCRCSEGYQGDGIHCLDIDECQ--LGEHSCGENASCT-NTEGGYTCMCAGRLSEPG 948
Query: 4356 CEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLC-DGYCYNGGTCQLDPETNVPV 4414
+ C + +D + N S C L DGYC + G C +
Sbjct: 949 ------LICPDSTPPPHLREDDHHYSVRNSD--SECPLSHDGYCLHDGVCMYIEALDKYA 1000
Query: 4415 CLCSTNWSGTQCERPAPKSSKSDHIS-TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRT 4473
C C + G +C+ K + H + +IV V +V L+ L++ L R
Sbjct: 1001 CNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQ 1060
Query: 4474 KTIRRQP 4480
K + + P
Sbjct: 1061 KLLSKNP 1067
Score = 134 bits (338), Expect = 2e-30
Identities = 93/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 3005 NGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSR 3064
NG + PFLI + + I +I T+G+NY L + +DF Y E+ IYW+D R
Sbjct: 36 NGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLER 95
Query: 3065 PNGSRINRMCLNGSDIKVVHNTAV-PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTI 3123
+ R+ LNGS + V N + +A++WI + + WS+ ++ II V+ + G I
Sbjct: 96 ---QLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHI 152
Query: 3124 LVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDY 3183
L+S LK+P ++++DP +++W + R +DG ++ET + A+++D
Sbjct: 153 LLS-ALKYPANVAVDPVERFIFWSSEVA-GSLYRADLDGVGVKALLETS-EKITAVSLDV 209
Query: 3184 VNRRLYWADENHIEFSN-------MDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKS 3236
+++RL+W N E SN DG H + + A++LF D I+++ K K+
Sbjct: 210 LDKRLFWIQYNR-EGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKT 268
Query: 3237 LSRAHKTSGAD--RLSLIYSWHAITDIQVYHSYRQP-------DVSKHLCMINNGGCSHL 3287
+ A+K +G D R++L S+ + +++V H QP + + LC + G CS
Sbjct: 269 IWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSST 328
Query: 3288 CLLAPGKTHTCACPTNFYLAADNRTC 3313
++H C C + L+ D + C
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 132 bits (333), Expect = 6e-30
Identities = 142/577 (24%), Positives = 231/577 (40%), Gaps = 79/577 (13%)
Query: 2150 DNGGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDET 2206
DNGGC QLC+ C C GY L E + +LL++ ++ +H D T
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHF-DGT 501
Query: 2207 NLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIK-DNWEDRQVIV 2265
+ + + Y A D++ N+I+++ I+ D + ++I
Sbjct: 502 DYGTLLSQQMGMVY-------ALDHDPVE---NKIYFAHTALKWIERANMDGSQRERLIE 551
Query: 2266 ENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLAL 2325
E V EGLA YWT S I R ++ R +IT P +A+
Sbjct: 552 EGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKR------SKIITKENISQPRGIAV 605
Query: 2326 DECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLG 2385
+FWT+ +P I S+L G V+ S+D++ P+G+TID+ +KLY+ D
Sbjct: 606 HPMAKRLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQS 664
Query: 2386 KIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSD 2445
IE DGS+R + ++ G ++AV+++Y+++SDW +++R NK TG D L+
Sbjct: 665 VIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGS 724
Query: 2446 IPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVT 2505
+ +P ++ V + PC NGGC +C G CSCR + D +
Sbjct: 725 M-LKPSSLV-VVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGK--- 778
Query: 2506 KNSSCNAYSEFECGNGECIDY-------------QLTCDGIPHCKDKSDEKLLYCENRSC 2552
+C A + G +D +++ D I + +++ + C
Sbjct: 779 ---TCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDC 835
Query: 2553 RRGFKPCYNRRCIPHGK--LCD------GENDCGDNSDELDCKVSTCATVEFRC--ADGT 2602
Y RCI G+ C G+ + DE + V C +C +G
Sbjct: 836 APVGCSMY-ARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGG 894
Query: 2603 CIPRSARCNQ--NIDCADASD----EKNC-NNTDCTHFYKLGVKTTGFIRCNSTSLCVLP 2655
+ R + Q I C D + E +C N CT+ T G C P
Sbjct: 895 YVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTN-------TEGGYTCMCAGRLSEP 947
Query: 2656 TWICDGS-------NDCGDYS---DELKCPVQNKHKC 2682
IC S D YS + +CP+ + C
Sbjct: 948 GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYC 984
Score = 131 bits (329), Expect = 2e-29
Identities = 91/357 (25%), Positives = 164/357 (45%), Gaps = 20/357 (5%)
Query: 1531 CAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEM--KKFLLYARRSEIRGVD 1588
C++ D G CS +C+ S C C L D+K+C + FLL+A +IR +
Sbjct: 439 CSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 1589 IDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDI 1648
D + + + + V +D D E ++Y+ + I+RA ++G+ E +I +
Sbjct: 498 FDGTDYGTLLS---QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
Query: 1649 QSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII---HGIDKPQCLAAHPVRG 1705
GLAVDW+ R YW D + + R D + K S I I +P+ +A HP+
Sbjct: 555 DVPEGLAVDWIGRRFYWT----DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAK 610
Query: 1706 KLYWTD---GNTINMANMDGSNSKILFQNQK-EPVGLSIDYVENKLYWISSGNGTINRCN 1761
+L+WTD I +++ G ++ + P G++ID++ +KLYW + I N
Sbjct: 611 RLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
Query: 1762 LDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGV 1821
LDG + + ++ A+ + + +W++D + + +KR G++ L+
Sbjct: 671 LDGSKRRRL--TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKP 728
Query: 1822 VHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIE 1878
+ V A+ G++ C NGGC +C T C C G+ + +C ++
Sbjct: 729 SSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA-WCSCREGFMKASDGKTCLALD 784
Score = 123 bits (308), Expect = 5e-27
Identities = 76/340 (22%), Positives = 158/340 (46%), Gaps = 26/340 (7%)
Query: 1555 ACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFD 1614
+CP + TC FL+++ + I +D + + + V D ++DF
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL----VVDAGVSVIMDFH 82
Query: 1615 ASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQ 1674
+E+R+YW D++ Q ++R F+NG+ E V + + +++ G+A++W++ + W S E
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIW--SNQQEGI 139
Query: 1675 INVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQ 1732
I V + G+ ++ + P +A PV ++W+ ++ A++DG K L +
Sbjct: 140 ITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETS 199
Query: 1733 KEPVGLSIDYVENKLYWI----SSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDK 1788
++ +S+D ++ +L+WI N I C+ DGG++ + + + A+++
Sbjct: 200 EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQH--NLFAMSLFGD 257
Query: 1789 KLWWADQNLAQLGTCSKRDGRNPTILRNKTS-------GVVH----MKVYDKEAQQGSNS 1837
+++++ + + +K G++ + +S VVH K D +
Sbjct: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKL 317
Query: 1838 CQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI 1877
C+L G CS + CMC GY L ++R C+ +
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
Score = 121 bits (303), Expect = 2e-26
Identities = 96/351 (27%), Positives = 161/351 (45%), Gaps = 32/351 (9%)
Query: 1238 SCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHF 1297
SC EG +C PF +IFS + I RID +Y LV ++ +DFH+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPF---LIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHY 83
Query: 1298 NQSLLYWTDVVEDRIYRGKL--SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSN 1355
N+ +YW D+ + R L S V IE V G+ ++WI + W +
Sbjct: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-------SGMAINWINEEVIWSNQQ 136
Query: 1356 LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRK 1415
I V + G+ + ++ A+++P +A+DP +FW+ A + A + G G K
Sbjct: 137 EGIITVTDMKGN-NSHILLSALKYPANVAVDPVERFIFWSSEVAG--SLYRADLDGVGVK 193
Query: 1416 TIYKDMKTGAWPNGLTVDHFEKRIVW----TDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471
+ ++T +++D +KR+ W + + I S YDG ++ I H +
Sbjct: 194 AL---LETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSV--HISKHPTQHN 248
Query: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQN-VSVIQKTSAQPF-DLQIYHPSRQPQA-- 1527
FA+SL+G ++++ W+ T+ ANK TG++ V + +S P +L++ HP QP+A
Sbjct: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAED 308
Query: 1528 ----PNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 1574
P KG CS +S C C LS D+K C ++ +
Sbjct: 309 DTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Score = 79.7 bits (195), Expect = 6e-14
Identities = 76/343 (22%), Positives = 143/343 (41%), Gaps = 37/343 (10%)
Query: 1861 CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE 1920
C G +C G FL++S I I E ++ + L+ +G S V +DFH
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTN-YEQLVVDAGVS--VIMDFHYN 84
Query: 1921 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 1980
IYW D+ + R + + +++ + N V G+A++WI + W++ +I V
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGS-RQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVT 143
Query: 1981 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTE-------WGQMPCIG-KARLDGSEKV 2032
+ G+ ++++S L P ++AV P + +FW+ + +G KA L+ SEK+
Sbjct: 144 DMKGNNSHILLS-ALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKI 202
Query: 2033 VLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLE---TGGNREMVLSGSNVDMFSV 2089
+S+D + +L+W + + GG+ + + ++F++
Sbjct: 203 ----------TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAM 252
Query: 2090 AVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVR--------- 2140
++FG I++S + H I + + V L E+K+ + +
Sbjct: 253 SLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSF-VPLGELKVVHPLAQPKAEDDTW 311
Query: 2141 EKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTC 2182
E +C G C + C CA GY L+ D C
Sbjct: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 72.4 bits (176), Expect = 1e-11
Identities = 102/458 (22%), Positives = 177/458 (38%), Gaps = 67/458 (14%)
Query: 2169 ACAHGYLAEDG-VTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNV-IA 2226
+C G LA +G TC+ +L++S SI D N YE V +
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGN---SIFRIDTEGTN-----YEQLVVDAGVSVI 78
Query: 2227 LAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWT 2286
+ F YN++R I++ D +Q + N ++ + +V G+A + + + W+
Sbjct: 79 MDFHYNEKR-----IYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWS 133
Query: 2287 SSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMR 2346
+ IT + + I +S +P +A+D + +FW++ E S+ R
Sbjct: 134 NQQEGIITVTDMK-------GNNSHILLSALKYPANVAVDPVERFIFWSS--EVAGSLYR 184
Query: 2347 STLTGKNAQVVVSTDILTPNGLTIDYRAEKLYF----SDGSLGKIERCEYDGSQRHVIVK 2402
+ L G + ++ T +++D ++L++ +GS I C+YDG H+
Sbjct: 185 ADLDGVGVKALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKH 243
Query: 2403 SGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVA----- 2457
+++++ + IF+S W + I +NK+TG D + P+G + V
Sbjct: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
Query: 2458 ----NDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
+DT E C L G C C C L D + C
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRK------YCEDV 357
Query: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDG 2573
+E N C L C P YC +C GF +P GK C
Sbjct: 358 NECAFWNHGC---TLGCKNTPGS--------YYC---TCPVGFV------LLPDGKRCHQ 397
Query: 2574 ENDCGDNSDEL--DCKVSTCATVEFRCADGTCIPRSAR 2609
C N E DC +++ + F C +G+ + R +
Sbjct: 398 LVSCPRNVSECSHDCVLTSEGPLCF-CPEGSVLERDGK 434
Score = 69.7 bits (169), Expect = 6e-11
Identities = 83/371 (22%), Positives = 156/371 (42%), Gaps = 37/371 (9%)
Query: 179 SCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTL 238
SC EG L N +C + P P L+ ++ +I G+ L G + +
Sbjct: 27 SCPEGTLAGNGNSTC---VGPA---PFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSV-IM 79
Query: 239 DFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLY 298
DF YNE I W++ + + +Q G E NI + NV MAI+W+ +
Sbjct: 80 DFHYNEKRIYWVDL-----ERQLLQRVFLNGSRQERVCNIEK---NVSGMAINWINEEVI 131
Query: 299 FVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDG 358
+ + I V + G+ L+ L P +AVDP+ +F++ + R D+DG
Sbjct: 132 WSNQQEGIITVTDMKGNNSHILLS-ALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDG 189
Query: 359 MNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD----YVGVVDYQGKNRHTVIQGRQVR 414
+ ++++ +E+ A++LD+++K ++W+ + + DY G + H Q
Sbjct: 190 VGVKALLET-SEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ-H 247
Query: 415 HLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW----GIRIYQKRTQPTV 470
+L+ +++F D ++ + I N+ G D+ I + +++ +++ QP
Sbjct: 248 NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDM-VRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 471 RSHACEVDP---YGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFY 527
E + G CS + ++ C C G+ L D + C+ F +
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH 365
Query: 528 G-----KGRPG 533
G K PG
Sbjct: 366 GCTLGCKNTPG 376
Score = 69.7 bits (169), Expect = 6e-11
Identities = 70/317 (22%), Positives = 129/317 (40%), Gaps = 45/317 (14%)
Query: 561 LDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
+DFH IY+ D L+ R ++G+ +E + + NV G+A++WI + W+N
Sbjct: 79 MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQE 137
Query: 621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAW 680
+ + + +L + +P + VDPV +++W+ + G + +A
Sbjct: 138 ----GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWS-------SEVAGSLYRAD 186
Query: 681 MDGFN-RQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739
+DG + + TS+ + ++LD L+W + N Y G ++
Sbjct: 187 LDGVGVKALLETSEKI--TAVSLDVLDKRLFWI-----QYNREGSNSLICSCDYDGGSVH 239
Query: 740 ---HP-----FGLSHHGNYVFWTDYMNGSIFQLDLITSEVTL---LRHERPPLFGLQIYD 788
HP F +S G+ +F++ + +I+ + T + + L PL L++
Sbjct: 240 ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVH 299
Query: 789 PRKQ---------QGDNMCRVNNGGC-STLCLAIPGGRVCACADNQLLDENGTTC-TFNP 837
P Q +C++ G C ST+C +C CA+ L + C N
Sbjct: 300 PLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
Query: 838 GEALPHICKAGEFRCKN 854
H C G CKN
Sbjct: 360 CAFWNHGCTLG---CKN 373
Score = 55.5 bits (132), Expect = 1e-06
Identities = 26/52 (50%), Positives = 31/52 (59%), Gaps = 6/52 (11%)
Query: 2951 CKCWPGFQLKDDGKTCVDIDECSSGFP----CSQQCINTYGTYKCLCTDGYE 2998
C+C GF DGK C DIDEC G P S +CINT G Y C C++GY+
Sbjct: 855 CQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ 904
Score = 49.3 bits (116), Expect = 9e-05
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCS--NHLKCSQVCEQHKH 1233
C L G CS+ + +C C EG L++D K CE V+ C+ NH C+ C+
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH-GCTLGCKNTPG 376
Query: 1234 TVKCSCYEGWKLDVDGESC 1252
+ C+C G+ L DG+ C
Sbjct: 377 SYYCTCPVGFVLLPDGKRC 395
Score = 48.5 bits (114), Expect = 2e-04
Identities = 43/129 (33%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 2902 RCIPSGGLCDNKDDCGDGSDERNCH-INECLSKKVSGC---SQDCQDLPVSYKCKCWPGF 2957
RCI G + G D + C I+EC V C S C + Y C+C G+
Sbjct: 845 RCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVCRCSEGY 903
Query: 2958 QLKDDGKTCVDIDECSSG-FPCSQ--QCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE 3014
Q DG C+DIDEC G C + C NT G Y C+C + P S
Sbjct: 904 Q--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG----RLSEPGLICPDSTPP 957
Query: 3015 PFLILADHH 3023
P L DHH
Sbjct: 958 PHLREDDHH 966
Score = 47.8 bits (112), Expect = 3e-04
Identities = 29/81 (35%), Positives = 33/81 (40%), Gaps = 10/81 (12%)
Query: 119 NCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCKDQDECA----VYGTCSQTCRNT 172
+C + C +C C C GF DG+ C D DEC V S C NT
Sbjct: 834 DCAPVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINT 891
Query: 173 HGSYTCSCVEGYLMQPDNRSC 193
G Y C C EGY Q D C
Sbjct: 892 EGGYVCRCSEGY--QGDGIHC 910
Score = 47.4 bits (111), Expect = 3e-04
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 2/75 (2%)
Query: 3800 PTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG-TCSHQC 3858
P + C+ C C Q S C C G+ + + CED+NEC + C+ C
Sbjct: 313 PEQKLCKLRKGNCSSTV-CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
Query: 3859 INVEGSYKCVCDQNF 3873
N GSY C C F
Sbjct: 372 KNTPGSYYCTCPVGF 386
Score = 43.5 bits (101), Expect = 0.005
Identities = 106/470 (22%), Positives = 166/470 (35%), Gaps = 97/470 (20%)
Query: 3144 LYWIDCCEYPHIGRVGMDGTNQSVV--IETKISRPMALTIDYVNRRLYWADENH--IEFS 3199
+YW+D E + RV ++G+ Q V IE +S + I+++N + W+++ I +
Sbjct: 88 IYWVDL-ERQLLQRVFLNGSRQERVCNIEKNVS---GMAINWINEEVIWSNQQEGIITVT 143
Query: 3200 NMDGSHRHKVPNQ-DIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI 3258
+M G++ H + + P +A+ E +I+W+ SL RA G +L+ + I
Sbjct: 144 DMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD-LDGVGVKALLETSEKI 202
Query: 3259 TDIQVYHSYRQPDV-SKHLCMI--NNGGCSHL---CLLAPGKTHTCACPTNFYLAADNRT 3312
T + + DV K L I N G + L C G H PT L A
Sbjct: 203 TAVSL-------DVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFA---- 251
Query: 3313 CLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALP 3372
S F D+ WK T+ + + D G P
Sbjct: 252 ------MSLFG---DRIFYSTWKMKTIWIANKHTGK--DMVRINLHSSFVPLGELKVVHP 300
Query: 3373 AFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
E+D + +L C + C+ CG + C
Sbjct: 301 LAQPKAEDDTWEPEQKL------CKLRKGNCSSTV--------------CGQDLQSHLC- 339
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD-KKTCGPHEFQCKNNNCI-P 3490
C+ Y + K+C ++ +CA + K T G + C + P
Sbjct: 340 --MCAEGYALSRDRKYC-------EDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
Query: 3491 DHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFD-CADGS----D 3545
D RC C N E C++ DCV + +G C +GS D
Sbjct: 391 DGKRCHQLVSCPRNVSE--------------CSH-DCVLTS---EGPLCFCPEGSVLERD 432
Query: 3546 ERNCETSCSKDQFRCSNGQCIP---AKWKCDGHEDCKYGEDEKSCEPASP 3592
+ C S D CS C+P W+CD DEKSC + P
Sbjct: 433 GKTCSGCSSPDNGGCSQ-LCVPLSPVSWECDCFPGYDLQLDEKSCAASGP 481
Score = 43.5 bits (101), Expect = 0.005
Identities = 85/392 (21%), Positives = 153/392 (39%), Gaps = 57/392 (14%)
Query: 3912 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 3971
+++ +IE N ++GM + + + +IWS Q G I + G NS ++ K P
Sbjct: 109 ERVCNIEKN--VSGMAINWINEEVIWSNQ-QEGIITVTDMKGN-----NSHILLSALKYP 160
Query: 3972 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 4031
++AVD V I+W+ + + S+ L+G LL + + A
Sbjct: 161 ANVAVDPVERFIFWS---------------SEVAGSLYRADLDGVGVKALL-ETSEKITA 204
Query: 4032 IAVNPKRGMMYWTVV---GDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWA 4088
++++ ++W G +S I DG + + K+ + A+ F +RI+++
Sbjct: 205 VSLDVLDKRLFWIQYNREGSNSLICSCDYDG--GSVHISKHPTQHNLFAMSLFGDRIFYS 262
Query: 4089 DFELSIIGSVLYDGSNSVVSVS--------SKQGLLHPHRIDIFEDYIYGAGPKNGVFRV 4140
+++ I +V ++ + ++HP ED + P+ + ++
Sbjct: 263 TWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTW--EPEQKLCKL 320
Query: 4141 QKFGHGSVEYLALNIDK-----TKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGAT 4193
+K G+ S ++ +G +S K + N C + C C P
Sbjct: 321 RK-GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYY 379
Query: 4194 CVCPEGKYLINGTCNDDSLLDDSC-KLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNH 4252
C CP G L+ L+ SC + E C+L +G L C C P S +
Sbjct: 380 CTCPVGFVLLPDGKRCHQLV--SCPRNVSECSHDCVLTSEGPL-CFC-PEGSVLERDGKT 435
Query: 4253 CSNYC--QNGG---TCVPSVLGRPTCSCALGF 4279
CS NGG CVP C C G+
Sbjct: 436 CSGCSSPDNGGCSQLCVPLSPVSWECDCFPGY 467
Score = 43.5 bits (101), Expect = 0.005
Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 8/97 (8%)
Query: 3791 SDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTS--VFCRCKPGFQRNMKNRQCEDLNEC 3848
++ Q +A + +D+ P G Y I C+C GF + K C D++EC
Sbjct: 817 TESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGK--LCSDIDEC 874
Query: 3849 L----VFGTCSHQCINVEGSYKCVCDQNFQERNNTCI 3881
V S +CIN EG Y C C + +Q C+
Sbjct: 875 EMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCL 911
Score = 43.1 bits (100), Expect = 0.006
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 6/64 (9%)
Query: 128 KCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAV-YGTCSQ--TCRNTHGSYTCSCVEGY 184
KC C C +G++ DG C D DEC + +C + +C NT G YTC C G
Sbjct: 887 KCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCA-GR 943
Query: 185 LMQP 188
L +P
Sbjct: 944 LSEP 947
Score = 40.0 bits (92), Expect = 0.054
Identities = 36/141 (25%), Positives = 52/141 (36%), Gaps = 25/141 (17%)
Query: 3746 SDEDHCG--GKLTYKARPCKKDEFACSNKKCIPMDLQ-CDRLDDCGDGSDEQGCRIAPTE 3802
SD+D C G Y + ++ C K D + C +D+C E G + P
Sbjct: 830 SDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDEC-----EMGVPVCPPA 884
Query: 3803 YTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNEC-LVFGTCSHQ--CI 3859
+ C + CRC G+Q + C D++EC L +C C
Sbjct: 885 ------------SSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCT 930
Query: 3860 NVEGSYKCVCDQNFQERNNTC 3880
N EG Y C+C E C
Sbjct: 931 NTEGGYTCMCAGRLSEPGLIC 951
Score = 33.1 bits (74), Expect = 6.5
Identities = 12/33 (36%), Positives = 18/33 (54%)
Query: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKA 195
G C C+ G+ CSC EG++ D ++C A
Sbjct: 750 GGCEHICKKRLGTAWCSCREGFMKASDGKTCLA 782
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 219 bits (557), Expect = 6e-56
Identities = 148/463 (31%), Positives = 197/463 (42%), Gaps = 85/463 (18%)
Query: 3384 DNSDELNC---DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDY 3440
+N +L C + +C SG CIP L+CNG +DC D DE C +CS +
Sbjct: 262 ENGKQLLCGRGENFLCASGI--------CIPGKLQCNGYNDCDDWSDEAHC---NCSENL 310
Query: 3441 FQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPH-EFQCKNNNCIPDHWRCDSQN 3499
F C T K C++ VCD DC D SDE NCD C P E +C + CI W CD +
Sbjct: 311 FHCHTGK-CLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEHRCGDGRCIAMEWVCDGDH 366
Query: 3500 DCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC---ETSCSKD 3556
DC D SDE NC + L + C NG C+ S F CDGD DC DGSDE NC +TSC +
Sbjct: 367 DCVDKSDEVNCSCHSQGLVE--CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEG 424
Query: 3557 QFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPT----CSSREYICAS--------- 3603
RC C+ + C G C +C P C + Y S
Sbjct: 425 DQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRT 481
Query: 3604 ---------DGCISASLKCN--------------GEYDCADGSDEMDCVTECKEDQFRCK 3640
A ++ N + D G C C+ + RC+
Sbjct: 482 QKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCE 541
Query: 3641 NKAHCIPIRWLCDGIHDCV----DGSDEENC---ERGGNICRADEFLCNNSLCKLHFWVC 3693
+ + ++W D DC + SD + C + C F C + C L C
Sbjct: 542 SVLGIVGLQWPEDT--DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRC 599
Query: 3694 DGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGG 3753
DG+ DC D+SDE + C C C +N+ CL+ +C+G +C D DE +C
Sbjct: 600 DGQADCDDDSDE--ENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654
Query: 3754 KLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
C+ DE C+N C+ DL CD DC D SDE C
Sbjct: 655 --------CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 190 bits (483), Expect = 2e-47
Identities = 136/436 (31%), Positives = 190/436 (43%), Gaps = 76/436 (17%)
Query: 3322 FRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGEND 3381
F C + CIP +C+ +DC D SDE C F C TG C + +CDG +D
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEA----HCNCSENLFHCHTGKCLNYSLVCDGYDD 330
Query: 3382 CGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC-SPDY 3440
CGD SDE NCD + + + +C + +CI + C+G DC D+ DE +C SC S
Sbjct: 331 CGDLSDEQNCDCNP--TTEHRC-GDGRCIAMEWVCDGDHDCVDKSDEVNC---SCHSQGL 384
Query: 3441 FQCKTTKHCISKLWVCDEDPDCADASDEANCD--KKTCGPHEFQCKNNNCIPDHWRCDSQ 3498
+C+ + CI + CD D DC D SDE NC + +C + +C N C+ C
Sbjct: 385 VECRNGQ-CIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGS 440
Query: 3499 NDCSDNSDEENCKP-QTCTLKDFLCANGDCVSSRF---------------WCDGDF---- 3538
+ C N+ NC + TL+ LC N S+ + W F
Sbjct: 441 SLCDPNNSLNNCSQCEPITLE--LCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
Query: 3539 --------------------DCADGSDERNCETSCSKDQFRCSNG-QCIPAKWKCDGHED 3577
D G C C + RC + + +W D D
Sbjct: 499 QTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TD 556
Query: 3578 C----KYGEDEKSC---EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVT 3630
C + D ++C + CS + C S C+ AS +C+G+ DC D SDE +C
Sbjct: 557 CSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC-- 614
Query: 3631 ECKE-DQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLH 3689
CKE D + C + C+ +CDG DC D DE+NC + C+ DE C N C
Sbjct: 615 GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC----SFCQDDELECANHACVSR 670
Query: 3690 FWVCDGEDDCGDNSDE 3705
CDGE DC D+SDE
Sbjct: 671 DLWCDGEADCSDSSDE 686
Score = 174 bits (440), Expect = 2e-42
Identities = 128/433 (29%), Positives = 190/433 (43%), Gaps = 73/433 (16%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQP-GRFQCGTGLCALPAF 3374
NC+ + F C T KC+ + CD DDCGD SDE +C C P +CG G C +
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDE-QNCD---CNPTTEHRCGDGRCIAMEW 360
Query: 3375 ICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP-- 3432
+CDG++DC D SDE+NC H G +C +N +CIP +C+G +DC D DE +C
Sbjct: 361 VCDGDHDCVDKSDEVNCSCH--SQGLVEC-RNGQCIPSTFQCDGDEDCKDGSDEENCSVI 417
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQC-----KNNN 3487
+ SC +C C+ C C + NC + C P + N+
Sbjct: 418 QTSCQEGDQRC-LYNPCLDS---CGGSSLCDPNNSLNNCSQ--CEPITLELCMNLPYNST 471
Query: 3488 CIPDHWRCDSQNDCSDNSD--------EENCKPQ----TCTLKDFLC----------ANG 3525
P+++ +Q + S + + + NC +CT+ C
Sbjct: 472 SYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRA 531
Query: 3526 DCVSSRFWCDG-----------DFDCA----DGSDERNC------ETSCSKDQFRCSNGQ 3564
C S+ C+ D DC+ + SD + C CS F+C +GQ
Sbjct: 532 LCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ 591
Query: 3565 CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSRE-YICASD-GCISASLKCNGEYDCADG 3622
C+ A +CDG DC DE++C C R+ + C S+ C+ ++ C+G DC D
Sbjct: 592 CVLASRRCDGQADCDDDSDEENC-----GCKERDLWECPSNKQCLKHTVICDGFPDCPDY 646
Query: 3623 SDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN 3682
DE +C + C++D+ C N A C+ CDG DC D SDE +C + FL
Sbjct: 647 MDEKNC-SFCQDDELECANHA-CVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMV 704
Query: 3683 NSLCKLHFWVCDG 3695
+ H DG
Sbjct: 705 HRAATEHHVCADG 717
Score = 160 bits (404), Expect = 4e-38
Identities = 125/482 (25%), Positives = 188/482 (39%), Gaps = 117/482 (24%)
Query: 2484 NGRVNCSCRGDRILLEDNRCVTKNSSCNAYSE----------------FECGNGECIDYQ 2527
NG+ RG+ L C+ CN Y++ F C G+C++Y
Sbjct: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYS 322
Query: 2528 LTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCK 2587
L CDG C D SDE+ C + R C + RCI +CDG++DC D SDE++C
Sbjct: 323 LVCDGYDDCGDLSDEQNCDCNPTTEHR----CGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Query: 2588 VSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCN--NTDCTHFYKLGVKTTGFIR 2645
+ VE C +G CIP + +C+ + DC D SDE+NC+ T C + +
Sbjct: 379 CHSQGLVE--CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS 436
Query: 2646 CNSTSLCVLPTWICDGSNDCGDYSDEL---------KCPVQNKHKCEEN----------- 2685
C +SLC P + + C + EL P H+ ++
Sbjct: 437 CGGSSLCD-PNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFP 495
Query: 2686 ------------YFSCP--SGRCILNTW--------ICDGQK------------------ 2705
+FSC +C +NT +C+ K
Sbjct: 496 ALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDT 555
Query: 2706 DCEDGRDEFHCDSSC----------SWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI 2755
DC +E + +C S + F C + +C+ CDG+ DC D DE +
Sbjct: 556 DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG 615
Query: 2756 CGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNK 2815
C D++ C ++ C+ +CDG DCPD DE + + C ++ C N
Sbjct: 616 CK----ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC------SFCQDDELECANH 665
Query: 2816 VCIPKQFVCDHDDDCGDGSDE------------SPQCGYRQCGTEEFSCADGRCLLNTQW 2863
C+ + CD + DC D SDE S + TE CADG + +Q
Sbjct: 666 ACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQL 725
Query: 2864 QC 2865
C
Sbjct: 726 AC 727
Score = 159 bits (402), Expect = 6e-38
Identities = 129/462 (27%), Positives = 175/462 (37%), Gaps = 79/462 (17%)
Query: 2506 KNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCI 2565
K C F C +G CI +L C+G C D SDE +C +C C+ +C+
Sbjct: 265 KQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEA--HC---NCSENLFHCHTGKCL 319
Query: 2566 PHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
+ +CDG +DCGD SDE +C + T E RC DG CI C+ + DC D SDE NC
Sbjct: 320 NYSLVCDGYDDCGDLSDEQNCDCN--PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Query: 2626 NNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEEN 2685
+ + G + C + C+ T+ CDG DC D SDE C V + C+E
Sbjct: 378 S-----------CHSQGLVECRN-GQCIPSTFQCDGDEDCKDGSDEENCSV-IQTSCQEG 424
Query: 2686 YFSCPSGRCILNTWICDGQKDCEDGRDEFHC----------------DSSCSWNQFACSA 2729
C C+ + C G C+ +C +S+ N F
Sbjct: 425 DQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRT 481
Query: 2730 QKCISKHWICD---------------------GEDDCGDGLDESDSICGAITCAADMFSC 2768
QK S W C E C A+ C C
Sbjct: 482 QKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRAL-CEHSKERC 540
Query: 2769 QGSRACVPRHWLCDGERDCPDGSDELS--TAGCAPN---NTCDENAFMCHNKVCIPKQFV 2823
+ V W + DC +E S P+ C + F C + C+
Sbjct: 541 ESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598
Query: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883
CD DC D SDE CG ++ + + C + L CDG DCPD+ DE
Sbjct: 599 CDGQADCDDDSDEE-NCGCKE--RDLWECPSNKQCLKHTVICDGFPDCPDYMDE----KN 651
Query: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
C C C N C+ CD + DC D SDE +C
Sbjct: 652 C----SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 158 bits (400), Expect = 1e-37
Identities = 139/482 (28%), Positives = 198/482 (41%), Gaps = 86/482 (17%)
Query: 796 NMCRVNNGGCSTLCLAI----PGGRVCACADNQLLDENGTTCTFNP----GEALPHICKA 847
+ C GC ++ + P C+ NQ N + F+P G+ L +C
Sbjct: 214 SFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQL--LCGR 271
Query: 848 GE-FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCD 906
GE F C + CI + +C+G +DC D SDE NC ++ F C +C+ +CD
Sbjct: 272 GENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNC-----SENLFHCHTGKCLNYSLVCD 326
Query: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT 966
G +DCG DE N C T + CG+GRCI W+CD + DC D++DE+ +C +
Sbjct: 327 GYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEV-NC---S 378
Query: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCFDNQFRCSSGRCIP--- 1020
C C++G+CI S + CD D+DC DGSDE C SC + RC C+
Sbjct: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCG 438
Query: 1021 GHWACDGDNDCGDFSDEAQIN---CTKEEIHSPAGCN---------------GNEFQCHP 1062
G CD +N + S I C +S + N + F
Sbjct: 439 GSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
Query: 1063 DGNCVPDL--WRCD---GEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCD 1117
NC L + C + D G C LC+H +K C S + W
Sbjct: 499 QTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRA---LCEH-SKERCESVLGIVGLQW--P 552
Query: 1118 GDIDC----EDQSDEDDC---DSFL--CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSD 1168
D DC E+ SD C D ++ C P C + C+ + C+G+ DC D SD
Sbjct: 553 EDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCR--SGQCVLASRRCDGQADCDDDSD 610
Query: 1169 EGYL-CDECSL----NNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVD----YCS 1219
E C E L +N C H + G CP+ + D K C C+
Sbjct: 611 EENCGCKERDLWECPSNKQCLKHTVICDG---FPDCPDYM----DEKNCSFCQDDELECA 663
Query: 1220 NH 1221
NH
Sbjct: 664 NH 665
Score = 152 bits (385), Expect = 6e-36
Identities = 129/467 (27%), Positives = 183/467 (39%), Gaps = 104/467 (22%)
Query: 2596 FRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLP 2655
F CA G CIP +CN DC D SDE +CN ++ C+ T C+
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSE------------NLFHCH-TGKCLNY 321
Query: 2656 TWICDGSNDCGDYSDELKCPVQ--NKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDE 2713
+ +CDG +DCGD SDE C +H+C + GRCI W+CDG DC D DE
Sbjct: 322 SLVCDGYDDCGDLSDEQNCDCNPTTEHRCGD-------GRCIAMEWVCDGDHDCVDKSDE 374
Query: 2714 FHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQ-GSR 2772
+C S S C +CI + CDG++DC DG DE + C+ SCQ G +
Sbjct: 375 VNC-SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEEN-------CSVIQTSCQEGDQ 426
Query: 2773 ACVPRHWL--CDGERDCPDGSDELSTAGCAP-----------NNTCDENAF--------- 2810
C+ L C G C + + + C P N+T N F
Sbjct: 427 RCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEAS 486
Query: 2811 --------------MCHN-------KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEE 2849
C+ + +PK CD + + P C C +
Sbjct: 487 ISWESSLFPALVQTNCYKYLMFFSCTILVPK---CDVNT-----GEHIPPC-RALCEHSK 537
Query: 2850 FSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAE---QSCNSSFFMCKNGRCIPS 2906
C ++ QW D DC +E N C + + C+ S F C++G+C+ +
Sbjct: 538 ERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLA 595
Query: 2907 GGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTC 2966
CD + DC D SDE NC C + + C + Q L + C +P D
Sbjct: 596 SRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHTVICDGFP------DCPDY 646
Query: 2967 VDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDE 3013
+D CS +C N + C+ D + D C SDE
Sbjct: 647 MDEKNCSFCQDDELECAN----HACVSRD---LWCDGEADCSDSSDE 686
Score = 128 bits (322), Expect = 1e-28
Identities = 75/173 (43%), Positives = 87/173 (50%), Gaps = 24/173 (13%)
Query: 2755 ICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
+CG + F C S C+P C+G DC D SDE A C C EN F CH
Sbjct: 268 LCGR----GENFLC-ASGICIPGKLQCNGYNDCDDWSDE---AHC----NCSENLFHCHT 315
Query: 2815 KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDH 2874
C+ VCD DDCGD SDE C T E C DGRC+ +W CDGD DC D
Sbjct: 316 GKCLNYSLVCDGYDDCGDLSDEQ-NCDCNP--TTEHRCGDGRCIA-MEWVCDGDHDCVDK 371
Query: 2875 SDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHI 2927
SDE +N C S C+NG+CIPS CD +DC DGSDE NC +
Sbjct: 372 SDE--VNCSCHS------QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Score = 127 bits (319), Expect = 3e-28
Identities = 107/408 (26%), Positives = 157/408 (38%), Gaps = 79/408 (19%)
Query: 3288 CLLAPGKTHTCA---CPTNFYLAADNRTCLS-----NCTASQ---FRCKTDKCIPFWWKC 3336
C P H C C ++ + C+ NC+ C+ +CIP ++C
Sbjct: 340 CDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQC 399
Query: 3337 DTVDDCGDGSDEPDDCPEFR--CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDT- 3393
D +DC DGSDE ++C + CQ G +C C C G + C N+ NC
Sbjct: 400 DGDEDCKDGSDE-ENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQC 455
Query: 3394 -----HVCLSGQFKCT--------KNQK---------CIPVNLRCNGQD----------- 3420
+C++ + T + QK P ++ N
Sbjct: 456 EPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILV 515
Query: 3421 -DCGDEEDERDCPENS-CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTC-- 3476
C E P + C +C++ + W ED DC+ +E N D +TC
Sbjct: 516 PKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQW--PEDTDCSQFPEE-NSDNQTCLM 572
Query: 3477 --------GPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDF--LCANGD 3526
P F+C++ C+ RCD Q DC D+SDEENC C +D +N
Sbjct: 573 PDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQ 629
Query: 3527 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 3586
C+ CDG DC D DE+NC + C D+ C+N C+ CDG DC DE
Sbjct: 630 CLKHTVICDGFPDCPDYMDEKNC-SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWD 688
Query: 3587 CEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKE 3634
C S +S ++ + CADG E+ CK+
Sbjct: 689 CVTLSINVNSSSFLMVHRAATE-------HHVCADGWQEILSQLACKQ 729
Score = 125 bits (313), Expect = 1e-27
Identities = 107/409 (26%), Positives = 154/409 (37%), Gaps = 99/409 (24%)
Query: 795 DNMCRVNNGGCSTLCLAIPGGRVCA-CADNQLLDENGTT---CTFNPGEALPHICKA--- 847
+N+ + G C L G C +D Q D N TT C A+ +C
Sbjct: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHD 367
Query: 848 ---------------GEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFK 892
G C+N CI + ++CDGD+DC DGSDE++ + SC + +
Sbjct: 368 CVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQR 427
Query: 893 CQNNRCIPKRWLCDGANDCGSNEDESN-QTCTARTCQVDQFSCGNGRCIPRAWLCDREDD 951
C N C+ C G++ C N +N C T ++ N P +
Sbjct: 428 CLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYF------- 477
Query: 952 CGDQTDEMASCEF--------------------------PTCEPLTQFVCKSGR--CISS 983
G +T + AS + P C+ T R C S
Sbjct: 478 -GHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHS 536
Query: 984 KWHCDS-----------DDDCG----DGSDEVGC------VHSCFDNQFRCSSGRCIPGH 1022
K C+S D DC + SD C V C + F+C SG+C+
Sbjct: 537 KERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLAS 596
Query: 1023 WACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDG 1082
CDG DC D SDE C + ++ ++C + C+ CDG DC D
Sbjct: 597 RRCDGQADCDDDSDEENCGCKERDL----------WECPSNKQCLKHTVICDGFPDCPDY 646
Query: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC 1131
DEK C+ C + C + C+++ CDG+ DC D SDE DC
Sbjct: 647 MDEKNCS----FC-QDDELEC-ANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 124 bits (311), Expect = 2e-27
Identities = 85/237 (35%), Positives = 112/237 (47%), Gaps = 49/237 (20%)
Query: 1011 FRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDL 1070
F C+SG CIPG C+G NDC D+SDEA NC++ N F CH G C+
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSE-----------NLFHCH-TGKCLNYS 322
Query: 1071 WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDD 1130
CDG DC D SDE+ C+ C+ T+ C GRCI WVCDGD DC D+SDE +
Sbjct: 323 LVCDGYDDCGDLSDEQNCD-----CNPTTEHRC-GDGRCIAMEWVCDGDHDCVDKSDEVN 376
Query: 1131 CDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVV 1190
C G + C N C+ C+G +DC DGSDE +CSV
Sbjct: 377 CSCHSQGLVE--CRN--GQCIPSTFQCDGDEDCKDGSDE---------------ENCSV- 416
Query: 1191 PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDV 1247
I SC EG ++ C + + C + S +C+ + CS E L++
Sbjct: 417 ----IQTSCQEG------DQRC-LYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLEL 462
Score = 115 bits (288), Expect = 1e-24
Identities = 69/198 (34%), Positives = 96/198 (48%), Gaps = 33/198 (16%)
Query: 3645 CIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSD 3704
CIP + C+G +DC D SDE +C C + F C+ C + VCDG DDCGD SD
Sbjct: 282 CIPGKLQCNGYNDCDDWSDEAHCN-----CSENLFHCHTGKCLNYSLVCDGYDDCGDLSD 336
Query: 3705 EAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKK 3764
E C T HRC + R C+ E +C+G +C D SDE +C C
Sbjct: 337 EQ-----NCDCNPTTEHRCGDGR-CIAMEWVCDGDHDCVDKSDEVNCS---------CHS 381
Query: 3765 DEFA-CSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDN---------VNPCGD 3814
C N +CIP QCD +DC DGSDE+ C + T +C++ ++ CG
Sbjct: 382 QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQT--SCQEGDQRCLYNPCLDSCGG 439
Query: 3815 DAYCNQIKTSVFC-RCKP 3831
+ C+ + C +C+P
Sbjct: 440 SSLCDPNNSLNNCSQCEP 457
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/182 (32%), Positives = 76/182 (41%), Gaps = 50/182 (27%)
Query: 2845 CGT-EEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRC 2903
CG E F CA G C+ + QC+G DC D SDEA N C+ + F C G+C
Sbjct: 269 CGRGENFLCASGICIPG-KLQCNGYNDCDDWSDEAHCN---------CSENLFHCHTGKC 318
Query: 2904 IPSGGLCDNKDDCGDGSDERNCHIN----------ECLSKK-VSGCSQDCQDLPVSYKCK 2952
+ +CD DDCGD SDE+NC N C++ + V DC D C
Sbjct: 319 LNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Query: 2953 CWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSD 3012
C + EC +G QCI + T++C D CK SD
Sbjct: 379 C-----------HSQGLVECRNG-----QCIPS--TFQC----------DGDEDCKDGSD 410
Query: 3013 EE 3014
EE
Sbjct: 411 EE 412
Score = 75.9 bits (185), Expect = 9e-13
Identities = 47/137 (34%), Positives = 58/137 (42%), Gaps = 16/137 (11%)
Query: 3712 KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN 3771
+ LC C + IC+ + CNG ++C D SDE HC C ++ F C
Sbjct: 266 QLLCGRGENFLCASG-ICIPGKLQCNGYNDCDDWSDEAHCN---------CSENLFHCHT 315
Query: 3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAP-TEYTCEDN-----VNPCGDDAYCNQIKTSV 3825
KC+ L CD DDCGD SDEQ C P TE+ C D C D C V
Sbjct: 316 GKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEV 375
Query: 3826 FCRCKPGFQRNMKNRQC 3842
C C +N QC
Sbjct: 376 NCSCHSQGLVECRNGQC 392
Score = 69.7 bits (169), Expect = 6e-11
Identities = 47/153 (30%), Positives = 61/153 (39%), Gaps = 35/153 (22%)
Query: 2479 CLLTPNGRVNCS-----CRGDRILLEDNRCV----------TKNSSCNAYSEFEC-GNGE 2522
CL+ CS CR + +L RC +N C +EC N +
Sbjct: 570 CLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ 629
Query: 2523 CIDYQLTCDGIPHCKDKSDEK-LLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNS 2581
C+ + + CDG P C D DEK +C++ C N C+ CDGE DC D+S
Sbjct: 630 CLKHTVICDGFPDCPDYMDEKNCSFCQDDELE-----CANHACVSRDLWCDGEADCSDSS 684
Query: 2582 DELDC-------------KVSTCATVEFRCADG 2601
DE DC V AT CADG
Sbjct: 685 DEWDCVTLSINVNSSSFLMVHRAATEHHVCADG 717
Score = 61.6 bits (148), Expect = 2e-08
Identities = 46/156 (29%), Positives = 70/156 (44%), Gaps = 32/156 (20%)
Query: 28 DQQLCDPGEFLCHDHV-TCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLG 86
D+ C+ E L H H C++ S +CDG DC D SDE C E +C G
Sbjct: 300 DEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRC--------G 351
Query: 87 TNKCVHLSQLCNGVLDCPDGYDEGVHC---QELLSNCQQLNCQYKCTMVRNSTRCYCEDG 143
+C+ + +C+G DC D DE V+C + L C+ C + ++ +C DG
Sbjct: 352 DGRCIAMEWVCDGDHDCVDKSDE-VNCSCHSQGLVECRNGQC------IPSTFQC---DG 401
Query: 144 FEITEDG----------RSCKDQDECAVYGTCSQTC 169
E +DG SC++ D+ +Y C +C
Sbjct: 402 DEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSC 437
Score = 58.2 bits (139), Expect = 2e-07
Identities = 35/96 (36%), Positives = 42/96 (43%), Gaps = 10/96 (10%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P F C CV S CDG DC DDSDE C E +CP N +C+
Sbjct: 580 CSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSN-------KQCL 631
Query: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNC 125
+ +C+G DCPD DE CQ+ C C
Sbjct: 632 KHTVICDGFPDCPDYMDEKNCSFCQDDELECANHAC 667
Score = 50.8 bits (120), Expect = 3e-05
Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 16/133 (12%)
Query: 26 DRDQQLCDPGE---FLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHI 82
D D++ C E + C + C+ + +CDG PDCPD DE + ++ E++C NH
Sbjct: 608 DSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECA-NHA 666
Query: 83 ACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCY-CE 141
CV C+G DC D DE C L N +N + R +T + C
Sbjct: 667 -------CVSRDLWCDGEADCSDSSDEW-DCVTLSIN---VNSSSFLMVHRAATEHHVCA 715
Query: 142 DGFEITEDGRSCK 154
DG++ +CK
Sbjct: 716 DGWQEILSQLACK 728
Score = 35.4 bits (80), Expect = 1.3
Identities = 48/210 (22%), Positives = 71/210 (33%), Gaps = 42/210 (20%)
Query: 4244 SGERCEVNHCSNYCQNGGTCVPSVL------------GRPTCSCALGFTGPNCGKTVCED 4291
+G++ N+ G C+P L C+C+ + GK +
Sbjct: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYS 322
Query: 4292 FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRY 4351
+G ++ C C P T RC C+ E DG +CV +
Sbjct: 323 LVCDGYDDCGDLSDEQNCDCNPT-TEHRCG----DGRCIAMEWVC---DGDHDCVDKSDE 374
Query: 4352 EGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGK-------IASSCQLCDGYC-YN--- 4400
C V C G CI + D +C +G I +SCQ D C YN
Sbjct: 375 VNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL 434
Query: 4401 ---GGTCQLDPETNVPVCLCSTNWSGTQCE 4427
GG+ DP ++ C +QCE
Sbjct: 435 DSCGGSSLCDPNNSLNNC--------SQCE 456
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 196 bits (498), Expect = 4e-49
Identities = 131/399 (32%), Positives = 172/399 (43%), Gaps = 84/399 (21%)
Query: 818 CACADNQLLDENGTTC-------------TFNPGEALPHICKAGEFRCKNRHCIQARWKC 864
C C + LL +G C +F PG L + C N C + +W C
Sbjct: 1312 CFCPEGTLL--HGGACLEPASCPCEWGRNSFPPGSVL-------QKDCGNCTCQEGQWHC 1362
Query: 865 DGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN-RCIPKRWLCDGANDCGSNEDESNQTCT 923
GD G E+ V +C + + CQ N C+P WLCD +DCG DE C
Sbjct: 1363 GGDG----GHCEELVP----ACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEG--CA 1412
Query: 924 ARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISS 983
A C Q +C +G C+P A LCDR+DDCGD TDE + +P P C GRC+
Sbjct: 1413 APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS---YPC--PQGLLACADGRCLPP 1467
Query: 984 KWHCDSDDDCGDGSDEVGCVH--SCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQIN 1041
CD DC D +DE C+ +C + C G C+ CDG DC D +DE +
Sbjct: 1468 ALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGH 1527
Query: 1042 CTKEEIHSPAG--------------------------CNGNEFQCHPDGNCVPDLWRCDG 1075
C + +P C EF+C G C P WRCD
Sbjct: 1528 CPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRC-GSGECTPRGWRCDQ 1586
Query: 1076 EKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDE--DDCDS 1133
E+DC DGSDE+GC G H C C++ +CDG C D SDE D C
Sbjct: 1587 EEDCADGSDERGCGGP--CAPHHA--PCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642
Query: 1134 F--LCGP-------PKHPCANDTSVCLQPEKLCNGKKDC 1163
L GP P++ C N T C+ + +C+G+ DC
Sbjct: 1643 LPALGGPNRTGLPCPEYTCPNGT--CIGFQLVCDGQPDC 1679
Score = 186 bits (473), Expect = 4e-46
Identities = 144/490 (29%), Positives = 180/490 (36%), Gaps = 95/490 (19%)
Query: 3277 CMINNGG-CSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQ-FRCKTDKCIPFW- 3333
C ++GG C LC CA + C C Q + C P
Sbjct: 1234 CGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACGPTCPPTCH 1293
Query: 3334 -------WKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI-CD-GENDCGD 3384
W C V C +G CPE G G C PA C+ G N
Sbjct: 1294 EQHPEPGWHCQVVA-CVEGCF----CPEGTLLHG------GACLEPASCPCEWGRNSFPP 1342
Query: 3385 NSD-ELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQC 3443
S + +C C GQ+ C G D EE C E C
Sbjct: 1343 GSVLQKDCGNCTCQEGQWHC--------------GGDGGHCEELVPACAEGEAL-----C 1383
Query: 3444 KTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSD 3503
+ HC+ W+CD DC D SDE C CG + C + +C+P CD Q+DC D
Sbjct: 1384 QENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGD 1443
Query: 3504 NSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRCS 3561
+DE + C CA+G C+ CDG DC D +DE +C + +C + C
Sbjct: 1444 GTDEPS---YPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCV 1500
Query: 3562 NGQCIPAKWKCDGHEDCKYGEDE---------------------------------KSCE 3588
+G C+ A CDG DC G DE S
Sbjct: 1501 DGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASAS 1560
Query: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPI 3648
PA P C E+ C S C +C+ E DCADGSDE C C C HC+
Sbjct: 1561 PA-PPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSP 1619
Query: 3649 RWLCDGIHDCVDGSDE--ENC---------ERGGNICRADEFLCNNSLCKLHFWVCDGED 3697
LCDG+ C DGSDE + C R G C E+ C N C VCDG+
Sbjct: 1620 EQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPC--PEYTCPNGTCIGFQLVCDGQP 1677
Query: 3698 DCGDNSDEAP 3707
DCG P
Sbjct: 1678 DCGRPGQVGP 1687
Score = 181 bits (460), Expect = 1e-44
Identities = 123/377 (32%), Positives = 154/377 (40%), Gaps = 77/377 (20%)
Query: 2517 ECGNGECIDYQLTCDGIP-HCKDKSDEKLLYCENRSCRRGFKPCY-NRRCIPHGKLCDGE 2574
+CGN C + Q C G HC++ +C G C N C+PHG LCD +
Sbjct: 1349 DCGNCTCQEGQWHCGGDGGHCEELVP---------ACAEGEALCQENGHCVPHGWLCDNQ 1399
Query: 2575 NDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFY 2634
+DCGD SDE C C + C+ G C+P + C++ DC D +DE + C
Sbjct: 1400 DDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP---SYPCPQ-- 1454
Query: 2635 KLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRC 2694
G + C + C+ P +CDG DC D +DE C + C SC G C
Sbjct: 1455 -------GLLAC-ADGRCLPPALLCDGHPDCLDAADEESC--LGQVTCVPGEVSCVDGTC 1504
Query: 2695 ILNTWICDGQKDCEDGRDE--FHCD---------------------------------SS 2719
+ +CDG DC DG DE HC
Sbjct: 1505 LGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPP 1564
Query: 2720 CSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHW 2779
C +F C + +C + W CD E+DC DG DE CG CA C CV
Sbjct: 1565 CGPFEFRCGSGECTPRGWRCDQEEDCADGSDERG--CGG-PCAPHHAPCARGPHCVSPEQ 1621
Query: 2780 LCDGERDCPDGSDE-------LSTAGCAPNNT---CDENAFMCHNKVCIPKQFVCDHDDD 2829
LCDG R CPDGSDE L G PN T C E + C N CI Q VCD D
Sbjct: 1622 LCDGVRQCPDGSDEGPDACGGLPALG-GPNRTGLPCPE--YTCPNGTCIGFQLVCDGQPD 1678
Query: 2830 CGDGSDESPQCGYRQCG 2846
CG P + CG
Sbjct: 1679 CGRPGQVGPSPEEQGCG 1695
Score = 171 bits (434), Expect = 1e-41
Identities = 146/511 (28%), Positives = 193/511 (37%), Gaps = 114/511 (22%)
Query: 798 CRVNNGG-CSTLCLAIP----------------GGRVCA--CADNQLLDENGTTCTFNPG 838
C ++GG C LC AI +C+ C Q+ + G TC
Sbjct: 1234 CGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACGPTCPPTCH 1293
Query: 839 EALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNH-SCPDD-------- 889
E P + C+ C++ + C +G+ C SCP +
Sbjct: 1294 EQHPE----PGWHCQVVACVEGCF-------CPEGTLLHGGACLEPASCPCEWGRNSFPP 1342
Query: 890 ----QFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
Q C N C +W C G G + +E C + NG C+P WL
Sbjct: 1343 GSVLQKDCGNCTCQEGQWHCGGD---GGHCEELVPACAEGEALCQE----NGHCVPHGWL 1395
Query: 946 CDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHS 1005
CD +DDCGD +DE C P C Q C SG C+ CD DDCGDG+DE +
Sbjct: 1396 CDNQDDCGDGSDE-EGCAAPGCGE-GQMTCSSGHCLPLALLCDRQDDCGDGTDEPS--YP 1451
Query: 1006 CFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN 1065
C C+ GRC+P CDG DC D +DE E C E C DG
Sbjct: 1452 CPQGLLACADGRCLPPALLCDGHPDCLDAADE-------ESCLGQVTCVPGEVSC-VDGT 1503
Query: 1066 CVPDLWRCDGEKDCEDGSDEKGCN-------------------GTIRLCDHKT------- 1099
C+ + CDG DC DG+DE + G++
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563
Query: 1100 -----KFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPE 1154
+F C S G C + W CD + DC D SDE C C P PCA C+ PE
Sbjct: 1564 PCGPFEFRCGS-GECTPRGWRCDQEEDCADGSDERGCGG-PCAPHHAPCARGPH-CVSPE 1620
Query: 1155 KLCNGKKDCPDGSDE-----------------GYLCDECSLNNGGCSNHCSVVPGRGIVC 1197
+LC+G + CPDGSDE G C E + NG C V G+ C
Sbjct: 1621 QLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQP-DC 1679
Query: 1198 SCPEGLQLNKDNKTCEIVDYCSNHLKCSQVC 1228
P + + + + C S CS+ C
Sbjct: 1680 GRPGQVGPSPEEQGCGAWGPWSPWGPCSRTC 1710
Score = 167 bits (423), Expect = 2e-40
Identities = 144/505 (28%), Positives = 187/505 (37%), Gaps = 103/505 (20%)
Query: 2463 CELSPCALLNGG-CHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFE-CGN 2520
C C +GG C LC C+ G + + C +E CG
Sbjct: 1229 CLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQ--CEGGQVYEACGP 1286
Query: 2521 GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCY-NRRCIPHGKLCDGENDC-- 2577
TC P C ++ E +C+ +C G C+ + HG C C
Sbjct: 1287 --------TCP--PTCHEQHPEPGWHCQVVACVEG---CFCPEGTLLHGGACLEPASCPC 1333
Query: 2578 --GDNSD------ELDCKVSTCATVEFRCA-DGTCIPRSARCNQNID-CADASDEKNCNN 2627
G NS + DC TC ++ C DG C + + CA+
Sbjct: 1334 EWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGDG------GHCEELVPACAE--------- 1378
Query: 2628 TDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYF 2687
G C CV W+CD +DCGD SDE C C E
Sbjct: 1379 --------------GEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPG---CGEGQM 1421
Query: 2688 SCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGD 2747
+C SG C+ +CD Q DC DG DE C AC+ +C+ +CDG DC D
Sbjct: 1422 TCSSGHCLPLALLCDRQDDCGDGTDE--PSYPCPQGLLACADGRCLPPALLCDGHPDCLD 1479
Query: 2748 GLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE-------------- 2793
DE +S G +TC SC C+ LCDG DCPDG+DE
Sbjct: 1480 AADE-ESCLGQVTCVPGEVSCVDG-TCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPP 1537
Query: 2794 -----------LSTAG-----CAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDES 2837
L TA +P C F C + C P+ + CD ++DC DGSDE
Sbjct: 1538 ASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDER 1597
Query: 2838 PQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP-----LNPKCKSAEQSCN 2892
CG C CA G ++ + CDG CPD SDE P L
Sbjct: 1598 G-CG-GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLP 1655
Query: 2893 SSFFMCKNGRCIPSGGLCDNKDDCG 2917
+ C NG CI +CD + DCG
Sbjct: 1656 CPEYTCPNGTCIGFQLVCDGQPDCG 1680
Score = 150 bits (378), Expect = 4e-35
Identities = 94/280 (33%), Positives = 121/280 (43%), Gaps = 49/280 (17%)
Query: 2682 CEENYFSCPSGRCIL----NTWICDGQKDCEDGRDEFHCDS---SCSWNQFACSAQ-KCI 2733
CE S P G + N +GQ C G D HC+ +C+ + C C+
Sbjct: 1333 CEWGRNSFPPGSVLQKDCGNCTCQEGQWHC--GGDGGHCEELVPACAEGEALCQENGHCV 1390
Query: 2734 SKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE 2793
W+CD +DDCGDG DE C A C +C C+P LCD + DC DG+DE
Sbjct: 1391 PHGWLCDNQDDCGDGSDEEG--CAAPGCGEGQMTCSSGH-CLPLALLCDRQDDCGDGTDE 1447
Query: 2794 LSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCA 2853
P+ C + C + C+P +CD DC D +DE G C E SC
Sbjct: 1448 -------PSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCV 1500
Query: 2854 DGRCLLNTQWQCDGDFDCPDHSDEAPLN----------------PKCKSAEQS------- 2890
DG CL Q CDG +DCPD +DE P + P S + +
Sbjct: 1501 DGTCLGAIQL-CDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASA 1559
Query: 2891 -----CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
C F C +G C P G CD ++DC DGSDER C
Sbjct: 1560 SPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC 1599
Score = 124 bits (310), Expect = 3e-27
Identities = 109/366 (29%), Positives = 140/366 (38%), Gaps = 64/366 (17%)
Query: 2682 CEENYFSCPSGRCILNTWIC--DGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWIC 2739
C E F CP G +L+ C CE GR+ F S Q C C W C
Sbjct: 1308 CVEGCF-CPEGT-LLHGGACLEPASCPCEWGRNSFPPGSVL---QKDCGNCTCQEGQWHC 1362
Query: 2740 DGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
G+ + L + CA CQ + CVP WLCD + DC DGSDE GC
Sbjct: 1363 GGDGGHCEELVPA--------CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE---EGC 1411
Query: 2800 APNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLL 2859
A C E C + C+P +CD DDCGDG+DE C +CADGRCL
Sbjct: 1412 AAPG-CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSY----PCPQGLLACADGRCL- 1465
Query: 2860 NTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDG 2919
CDG DC D +DE + +C C +G C+ + LCD DC DG
Sbjct: 1466 PPALLCDGHPDCLDAADEESC-----LGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDG 1520
Query: 2920 SDERNCHIN--------------------ECLSKKVSGCSQDCQDLPVSYKC---KCWPG 2956
+DE H + S ++ S P ++C +C P
Sbjct: 1521 ADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPR 1580
Query: 2957 FQLKDDGKTCVD-IDECSSGFPCSQQCINTYGTYKCL-----------CTDGYEIQPDNP 3004
D + C D DE G PC+ C+ C DG + PD
Sbjct: 1581 GWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDAC 1640
Query: 3005 NGCKSL 3010
G +L
Sbjct: 1641 GGLPAL 1646
Score = 122 bits (305), Expect = 1e-26
Identities = 93/333 (27%), Positives = 120/333 (36%), Gaps = 115/333 (34%)
Query: 789 PRKQQGDNMCRVNNGGCSTLCLAIPGGRVCA----CADNQLLDENGTTCTFNPGEALPHI 844
P +G+ +C+ NG C +P G +C C D DE G PG
Sbjct: 1374 PACAEGEALCQ-ENGHC------VPHGWLCDNQDDCGDGS--DEEGCAA---PG------ 1415
Query: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
C G+ C + HC+ CD DDC DG+DE S + CP C + RC+P L
Sbjct: 1416 CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS-----YPCPQGLLACADGRCLPPALL 1470
Query: 905 CDGANDCGSNEDESNQTCTAR-TCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDE----- 958
CDG DC DE ++C + TC + SC +G C+ LCD DC D DE
Sbjct: 1471 CDGHPDCLDAADE--ESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHC 1528
Query: 959 ----------------------------MASCEFPTCEPLTQFVCKSGRCISSKWHCDSD 990
++ P C P +F C SG C W CD +
Sbjct: 1529 PLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPF-EFRCGSGECTPRGWRCDQE 1587
Query: 991 DDCGDGSDEVGC--------------------------VHSCFDN--------------- 1009
+DC DGSDE GC V C D
Sbjct: 1588 EDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALG 1647
Query: 1010 ----------QFRCSSGRCIPGHWACDGDNDCG 1032
++ C +G CI CDG DCG
Sbjct: 1648 GPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCG 1680
Score = 78.6 bits (192), Expect = 1e-13
Identities = 86/317 (27%), Positives = 114/317 (35%), Gaps = 71/317 (22%)
Query: 2727 CSAQKCISKHWICDGEDDCG-DGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGER 2785
C A+ +H+ D CG D + + +C AI AD + G LC +
Sbjct: 1216 CHAEVPPQQHYEWCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQC 1275
Query: 2786 D-----------CPDGSDE--------LSTAGCAPNNTCDENAFMCHNKVCI-PKQFVCD 2825
+ CP E C C E + H C+ P C+
Sbjct: 1276 EGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLL-HGGACLEPASCPCE 1334
Query: 2826 HDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCK 2885
G + P Q +C +G QW C GD H +E L P C
Sbjct: 1335 W------GRNSFPPGSVLQKDCGNCTCQEG------QWHCGGD---GGHCEE--LVPACA 1377
Query: 2886 SAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDL 2945
E C +NG C+P G LCDN+DDCGDGSDE C C +++ S C L
Sbjct: 1378 EGEALCQ------ENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHC--L 1429
Query: 2946 PVSYKCKCWPGFQLKDDGKTCVD-IDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP--- 3001
P++ C D C D DE S +PC Q + C DG + P
Sbjct: 1430 PLALLC---------DRQDDCGDGTDEPS--YPCPQGLL--------ACADGRCLPPALL 1470
Query: 3002 -DNPNGCKSLSDEEPFL 3017
D C +DEE L
Sbjct: 1471 CDGHPDCLDAADEESCL 1487
Score = 72.4 bits (176), Expect = 1e-11
Identities = 47/129 (36%), Positives = 56/129 (43%), Gaps = 15/129 (11%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGL-CALPAFI 3375
C +FRC + +C P W+CD +DC DGSDE C C P C G C P +
Sbjct: 1565 CGPFEFRCGSGECTPRGWRCDQEEDCADGSDERG-CGG-PCAPHHAPCARGPHCVSPEQL 1622
Query: 3376 CDGENDCGDNSDELN--CDTHVCLSG---------QFKCTKNQKCIPVNLRCNGQDDCGD 3424
CDG C D SDE C L G ++ C N CI L C+GQ DCG
Sbjct: 1623 CDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCP-NGTCIGFQLVCDGQPDCGR 1681
Query: 3425 EEDERDCPE 3433
PE
Sbjct: 1682 PGQVGPSPE 1690
Score = 68.6 bits (166), Expect = 1e-10
Identities = 65/265 (24%), Positives = 88/265 (33%), Gaps = 63/265 (23%)
Query: 985 WHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTK 1044
WHC V CV CF C G + G G + A C
Sbjct: 1301 WHCQV----------VACVEGCF-----CPEGTLLHG----------GACLEPASCPCEW 1335
Query: 1045 EEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCW 1104
P G + + C GNC +G+ C G D C + C C
Sbjct: 1336 GRNSFPPG-SVLQKDC---GNCTCQ----EGQWHC--GGDGGHCEELVPACAEGEAL-CQ 1384
Query: 1105 STGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCP 1164
G C+ W+CD DC D SDE+ C + CG + C++ CL LC+ + DC
Sbjct: 1385 ENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGH--CLPLALLCDRQDDCG 1442
Query: 1165 DGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKC 1224
DG+DE CP+GL D + C H C
Sbjct: 1443 DGTDEPSY-------------------------PCPQGLLACADGRCLPPALLCDGHPDC 1477
Query: 1225 SQVCEQHKHTVKCSCYEGWKLDVDG 1249
++ + +C G VDG
Sbjct: 1478 LDAADEESCLGQVTCVPGEVSCVDG 1502
Score = 63.9 bits (154), Expect = 3e-09
Identities = 37/91 (40%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Query: 24 GADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIA 83
G D C G C D C+ + LCDG PDC D +DE ++C +V C ++
Sbjct: 1444 GTDEPSYPCPQGLLACADG-RCLPPALLCDGHPDCLDAADE--ESCLGQVT--CVPGEVS 1498
Query: 84 CLGTNKCVHLSQLCNGVLDCPDGYDEGV-HC 113
C+ C+ QLC+GV DCPDG DEG HC
Sbjct: 1499 CVD-GTCLGAIQLCDGVWDCPDGADEGPGHC 1528
Score = 62.4 bits (150), Expect = 1e-08
Identities = 53/160 (33%), Positives = 65/160 (40%), Gaps = 36/160 (22%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P EF C C + W CD + DC D SDE P C +H C CV
Sbjct: 1565 CGPFEFRCGSG-ECTPRGWRCDQEEDCADGSDERGCGGP------CAPHHAPCARGPHCV 1617
Query: 92 HLSQLCNGVLDCPDGYDEGVH-CQELLS----NCQQLNC-QYKCTMVRNSTRCYCEDGFE 145
QLC+GV CPDG DEG C L + N L C +Y C N T C GF+
Sbjct: 1618 SPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCP---NGT-CI---GFQ 1670
Query: 146 ITEDG----------------RSCKDQDECAVYGTCSQTC 169
+ DG + C + +G CS+TC
Sbjct: 1671 LVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTC 1710
Score = 62.0 bits (149), Expect = 1e-08
Identities = 43/148 (29%), Positives = 57/148 (38%), Gaps = 7/148 (4%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C GE LC ++ CV WLCD DC D SDE P C + C + C+
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAP-----GCGEGQMTC-SSGHCL 1429
Query: 92 HLSQLCNGVLDCPDGYDEGVH-CQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDG 150
L+ LC+ DC DG DE + C + L C C + C E
Sbjct: 1430 PLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQ 1489
Query: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTC 178
+C + V GTC + G + C
Sbjct: 1490 VTCVPGEVSCVDGTCLGAIQLCDGVWDC 1517
Score = 58.2 bits (139), Expect = 2e-07
Identities = 89/348 (25%), Positives = 125/348 (35%), Gaps = 100/348 (28%)
Query: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
C Q C+ C+ + +CDG DC DE + AR + S +P W
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERH---CARNLLMWLPS------LPALWA 2441
Query: 946 CDREDDCGDQTDEMASCEFPT----CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVG 1001
MA P C P +Q C SG C+S++ CD DC DGSDE G
Sbjct: 2442 ASTVPF---MMPTMALPGLPASRALCSP-SQLSCGSGECLSAERRCDLRPDCQDGSDEDG 2497
Query: 1002 CVHSCFDNQFRCSSGRCIPGHWA--CDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQ 1059
CV C+ W+ CG + ++E+ P
Sbjct: 2498 CVD-------------CVLAPWSVWSSCSRSCG-----LGLTFQRQELLRPP-------- 2531
Query: 1060 CHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAW-VCDG 1118
P G+C D +R + C ++ C ++ W +AW C
Sbjct: 2532 -LPGGSCPRDRFR---SQSC-----------FVQACPVAGAWAMW-------EAWGPCSV 2569
Query: 1119 DIDCEDQSDEDDCDSFLCGPPKH---PC---ANDTSVC-LQPEKLCNGKKDC-------- 1163
QS + C + PPK+ PC + + + C LQP C+G DC
Sbjct: 2570 SCGGGHQSRQRSC---VDPPPKNGGAPCPGASQERAPCGLQP---CSGGTDCELGRVYVS 2623
Query: 1164 PDGSDEGYL--CDECSLN---NGGCSNHCSVVPGRGIVCSCPEGLQLN 1206
D +G + C L+ N CS HC V G C CP GL L+
Sbjct: 2624 ADLCQKGLVPPCPPSCLDPKANRSCSGHC--VEG----CRCPPGLLLH 2665
Score = 57.0 bits (136), Expect = 4e-07
Identities = 36/127 (28%), Positives = 46/127 (36%), Gaps = 19/127 (14%)
Query: 837 PGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN 896
PG P C G+ C+ C++ CDG +DCLDGSDE C N
Sbjct: 2383 PGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERH--------------CARN 2428
Query: 897 RC-----IPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDD 951
+P W + C Q SCG+G C+ CD D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488
Query: 952 CGDQTDE 958
C D +DE
Sbjct: 2489 CQDGSDE 2495
Score = 55.5 bits (132), Expect = 1e-06
Identities = 63/251 (25%), Positives = 86/251 (34%), Gaps = 47/251 (18%)
Query: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWV 3455
C GQ C + C+ C+G++DC D DER C N + LW
Sbjct: 2391 CGPGQTPC-EVLGCVEQAQVCDGREDCLDGSDERHCARNLLM--------WLPSLPALWA 2441
Query: 3456 CDEDPDCAD--ASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQ 3513
P A + C P + C + C+ RCD + DC D SDE+ C
Sbjct: 2442 ASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCV-- 2499
Query: 3514 TCTLKDFLCANGDCVSSRF--WCDGDFDCADGSDERNCET--------SCSKDQFRCSN- 3562
DCV + + W C G + E SC +D+FR +
Sbjct: 2500 ------------DCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSC 2547
Query: 3563 -GQCIP-----AKWKCDG--HEDCKYGED--EKSCEPASPTCSSREYICASDGCISASLK 3612
Q P A W+ G C G ++SC P AS L+
Sbjct: 2548 FVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQ 2607
Query: 3613 -CNGEYDCADG 3622
C+G DC G
Sbjct: 2608 PCSGGTDCELG 2618
Score = 53.9 bits (128), Expect = 4e-06
Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 28/96 (29%)
Query: 3729 CLQSEQMCNGIDECGDNSDEDHCGGKLTY--------------------KARP------- 3761
C++ Q+C+G ++C D SDE HC L A P
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRA 2462
Query: 3762 -CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
C + +C + +C+ + +CD DC DGSDE GC
Sbjct: 2463 LCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 53.1 bits (126), Expect = 6e-06
Identities = 34/109 (31%), Positives = 40/109 (36%), Gaps = 32/109 (29%)
Query: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCE------------------------ 3588
C Q C C+ CDG EDC G DE+ C
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 3589 -------PASPT-CSSREYICASDGCISASLKCNGEYDCADGSDEMDCV 3629
PAS CS + C S C+SA +C+ DC DGSDE CV
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCV 2499
Score = 52.8 bits (125), Expect = 8e-06
Identities = 74/302 (24%), Positives = 96/302 (31%), Gaps = 74/302 (24%)
Query: 2689 CPSGRCILNTWICDGQKDCED------------GRDEFHCDSSCSWNQFACSAQKCISKH 2736
C SG C+L CDG DCED G FH S + SAQ H
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFH---STAKTLALSSAQPGQLLH 2297
Query: 2737 WICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGE------------ 2784
W +G + +S G + VP H GE
Sbjct: 2298 WPREGLAETEHWPPGQESPTSPTETRP---VSPGPASGVPHH----GESVQMVTTTPIPQ 2350
Query: 2785 ---RDCPDGSDELSTA-----------------GCAPNNTCDENAFMCHNKVCIPKQFVC 2824
R P G ++ G P C C C+ + VC
Sbjct: 2351 MEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVC 2410
Query: 2825 DHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDG-DFDCPDHSDEAPLNPK 2883
D +DC DGSDE R C L W F P + P
Sbjct: 2411 DGREDCLDGSDE------RHCARNLLMWLPS---LPALWAASTVPFMMPTMA-----LPG 2456
Query: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLS---KKVSGCSQ 2940
++ C+ S C +G C+ + CD + DC DGSDE C +C+ S CS+
Sbjct: 2457 LPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC--VDCVLAPWSVWSSCSR 2514
Query: 2941 DC 2942
C
Sbjct: 2515 SC 2516
Score = 52.4 bits (124), Expect = 1e-05
Identities = 83/340 (24%), Positives = 110/340 (32%), Gaps = 91/340 (26%)
Query: 2720 CSWNQFACSAQKCISKHWICDGEDDCGDGLDES-------------DSICGAIT------ 2760
C Q C C+ + +CDG +DC DG DE ++ A T
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 2761 -------------CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGC--APNNTC 2805
C+ SC GS C+ CD DC DGSDE C AP +
Sbjct: 2451 TMALPGLPASRALCSPSQLSC-GSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVW 2509
Query: 2806 DENAFMCHNKVCIPKQFVCD---HDDDCGDGSDESPQCGYRQC------------GTEEF 2850
+ C + +Q + C S C + C G
Sbjct: 2510 SSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSV 2569
Query: 2851 SCADGRCLLNTQWQC------DGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCI 2904
SC G + Q C +G CP S E + Q C S C+ GR
Sbjct: 2570 SCGGGH--QSRQRSCVDPPPKNGGAPCPGASQE-----RAPCGLQPC-SGGTDCELGRVY 2621
Query: 2905 PSGGLCDN------KDDCGDGSDERNCHINECLSKKVSGCS-------QDCQDLPVSYKC 2951
S LC C D R+C C V GC D + LP+S +C
Sbjct: 2622 VSADLCQKGLVPPCPPSCLDPKANRSCS-GHC----VEGCRCPPGLLLHDTRCLPLS-EC 2675
Query: 2952 KCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKC 2991
C G +LK G + + + CS QC+ G C
Sbjct: 2676 PCLVGEELKWPGVSFL-LGNCS-------QCVCEKGELLC 2707
Score = 52.0 bits (123), Expect = 1e-05
Identities = 30/113 (26%), Positives = 38/113 (33%), Gaps = 36/113 (31%)
Query: 2552 CRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC------------------------- 2586
C G PC C+ ++CDG DC D SDE C
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 2587 ---------KVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDC 2630
+ C+ + C G C+ RC+ DC D SDE C DC
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC--VDC 2501
Score = 49.3 bits (116), Expect = 9e-05
Identities = 36/124 (29%), Positives = 48/124 (38%), Gaps = 9/124 (7%)
Query: 3349 PDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCL-SGQFKCTKNQ 3407
P P +C PG+ C C A +CDG DC D SDE +C ++ +
Sbjct: 2383 PGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAA 2442
Query: 3408 KCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASD 3467
+P + G C SP C + + C+S CD PDC D SD
Sbjct: 2443 STVPFMMPTMALP--GLPASRALC-----SPSQLSCGSGE-CLSAERRCDLRPDCQDGSD 2494
Query: 3468 EANC 3471
E C
Sbjct: 2495 EDGC 2498
Score = 47.4 bits (111), Expect = 3e-04
Identities = 34/120 (28%), Positives = 44/120 (36%), Gaps = 33/120 (27%)
Query: 1050 PAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTI----------------- 1092
P C + C G CV CDG +DC DGSDE+ C +
Sbjct: 2388 PVQCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 1093 --------------RLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGP 1138
R ++ SC S G C++ CD DC+D SDED C + P
Sbjct: 2447 FMMPTMALPGLPASRALCSPSQLSCGS-GECLSAERRCDLRPDCQDGSDEDGCVDCVLAP 2505
Score = 47.0 bits (110), Expect = 4e-04
Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 20/144 (13%)
Query: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650
C + C C+ ++ C+ DC D SDE++C + + + + ST
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARN-----LLMWLPSLPALWAASTV 2445
Query: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDG 2710
++PT G ++ C + SC SG C+ CD + DC+DG
Sbjct: 2446 PFMMPTMALPGLP-------------ASRALCSPSQLSCGSGECLSAERRCDLRPDCQDG 2492
Query: 2711 RDEFHCDSS--CSWNQFACSAQKC 2732
DE C W+ ++ ++ C
Sbjct: 2493 SDEDGCVDCVLAPWSVWSSCSRSC 2516
Score = 44.3 bits (103), Expect = 0.003
Identities = 37/168 (22%), Positives = 58/168 (34%), Gaps = 23/168 (13%)
Query: 3309 DNRTCLSNCTASQFRCKTDK-CIPFWWKCDTVDDCGD----GSDEPDDCPEFRCQPGRFQ 3363
D++ C C + + D C+P CD D G GS D C CQ G+
Sbjct: 4090 DDQVCQKGCRCPKGSLEQDGGCVPIG-HCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLS 4148
Query: 3364 CGTGLCALPAFICDGE--------NDCGDNSDELNCDTHVCLSGQFKCTKNQK------- 3408
C C P + CG + + S +C + Q
Sbjct: 4149 CTAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQ 4208
Query: 3409 --CIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLW 3454
C P+ L+ GD + +C SC+P+ C+ T+ + + W
Sbjct: 4209 PSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAVPEAW 4256
Score = 43.9 bits (102), Expect = 0.004
Identities = 23/58 (39%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 3575 HEDCKYGEDEKSCEPASPT---CSSREYICASDGCISASLKCNGEYDCADGSDEMDCV 3629
H D + CEP SP C CAS C+ C+G DC DGSDE CV
Sbjct: 2212 HSDVPLQVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 43.5 bits (101), Expect = 0.005
Identities = 76/349 (21%), Positives = 105/349 (30%), Gaps = 86/349 (24%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE-----------------------PDDCP 3353
C Q C+ C+ CD +DC DGSDE P P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 3354 EFR----------CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC 3403
C P + CG+G C CD DC D SDE C V
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWS 2510
Query: 3404 TKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCA 3463
+ ++ C + L Q E P SC D F+ ++ C + C A
Sbjct: 2511 SCSRSC-GLGLTFQRQ-----ELLRPPLPGGSCPRDRFR---SQSCF--VQACPVAGAWA 2559
Query: 3464 DASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCA 3523
C G H Q + +C+ + + + C Q C+
Sbjct: 2560 MWEAWGPCSVSCGGGH--QSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCS------G 2611
Query: 3524 NGDCVSSRFWCDGDF-----------DCADGSDERNCETSCSKDQFRCSNG------QCI 3566
DC R + D C D R+C C + RC G +C+
Sbjct: 2612 GTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHC-VEGCRCPPGLLLHDTRCL 2670
Query: 3567 PAKWKCDGHEDCKYGEDEK---------SCEPASPTCSSREYICASDGC 3606
P +C C GE+ K +C C E +C GC
Sbjct: 2671 PLS-EC----PCLVGEELKWPGVSFLLGNCSQC--VCEKGELLCQPGGC 2712
Score = 43.5 bits (101), Expect = 0.005
Identities = 52/198 (26%), Positives = 74/198 (37%), Gaps = 51/198 (25%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE------------------SLDTCP--- 70
C PG+ C + + CV Q+ +CDG DC D SDE + T P
Sbjct: 2391 CGPGQTPC-EVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMM 2449
Query: 71 --------EEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEG--VHC----QEL 116
C + ++C G+ +C+ + C+ DC DG DE V C +
Sbjct: 2450 PTMALPGLPASRALCSPSQLSC-GSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSV 2508
Query: 117 LSNCQQLNCQYKCTMVRNSTRCYCEDGFEITED---GRSCKDQDECAV---------YGT 164
S+C + +C T R G D +SC Q C V +G
Sbjct: 2509 WSSCSR-SCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQ-ACPVAGAWAMWEAWGP 2566
Query: 165 CSQTCRNTHGSYTCSCVE 182
CS +C H S SCV+
Sbjct: 2567 CSVSCGGGHQSRQRSCVD 2584
Score = 43.5 bits (101), Expect = 0.005
Identities = 121/555 (21%), Positives = 176/555 (31%), Gaps = 153/555 (27%)
Query: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDS-VNCFN------HSCPDDQFKCQNN 896
+C + C + C+ A +CD DC DGSDED V+C SC C
Sbjct: 2463 LCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSC---SRSCGLG 2519
Query: 897 RCIPKRWLCDGANDCGS--NEDESNQTCTARTCQVD------------QFSCGNGRCIPR 942
++ L GS + +Q+C + C V SCG G +
Sbjct: 2520 LTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQ 2579
Query: 943 AWLCDRED-----DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGS 997
D C + E A C C T C+ GR S D C G
Sbjct: 2580 RSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGTD--CELGRVYVSA------DLCQKGL 2631
Query: 998 DEVGCVHSCFDNQF-RCSSGRCIPGHWACDG----DNDCGDFSDEAQINCTKEEIHSP-- 1050
C SC D + R SG C+ G G D C S+ + EE+ P
Sbjct: 2632 -VPPCPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCL--VGEELKWPGV 2688
Query: 1051 ---------AGCNGNEFQCHPDGNCVPDLWR-------CD-------------------- 1074
C E C P G +P W CD
Sbjct: 2689 SFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAA 2748
Query: 1075 -GEKDCE-DGSDEKGCNGTIRLCDHK----TKFSCWS--TGRCI---------NKAWVC- 1116
G CE D + +GC+ +C + T ++ WS + C+ +++ +C
Sbjct: 2749 WGGAPCEGDRQELQGCH---TVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCP 2805
Query: 1117 -DGDIDCE-DQSDEDDCDSFLCGPPK-----HPCANDTSVC--------LQPEKLCNGKK 1161
GD C D + E+ C +C P P + ++ C L G
Sbjct: 2806 SPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDT 2865
Query: 1162 DCPDGSDEGYLC------------------DECSLNNGGCSNHCSVVPGRGIV------- 1196
CP + C ++C G C C + G GI
Sbjct: 2866 TCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLC-LTQGPGIECTGFCAP 2924
Query: 1197 -CSCPEGLQLNKDNKTCEIVDYC----SNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGES 1251
C+CP GL L+ N +C C L S + C+C G K+ E
Sbjct: 2925 GCTCPPGLFLH--NASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSG-KMACTSER 2981
Query: 1252 CTSVDPFEAFIIFSI 1266
C + + ++S+
Sbjct: 2982 CPVACGWSPWTLWSL 2996
Score = 42.4 bits (98), Expect = 0.011
Identities = 21/42 (50%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Query: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP 70
Q C PGE C D TC+ LCDG DCPD +DE CP
Sbjct: 1489 QVTCVPGEVSCVDG-TCLGAIQLCDGVWDCPDGADEGPGHCP 1529
Score = 41.2 bits (95), Expect = 0.024
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
C V RCA G C+ R C+ +DC D SDE+ C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 41.2 bits (95), Expect = 0.024
Identities = 74/334 (22%), Positives = 104/334 (31%), Gaps = 113/334 (33%)
Query: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERG-------------------- 3670
+C Q C+ C+ +CDG DC+DGSDE +C R
Sbjct: 2390 QCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFM 2448
Query: 3671 ------------GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCV------- 3711
+C + C + C CD DC D SDE D CV
Sbjct: 2449 MPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE--DGCVDCVLAPW 2506
Query: 3712 -------------------KFLCPSTRPHRCRNNRICLQS--EQMC---------NGIDE 3741
+ L P C +R QS Q C
Sbjct: 2507 SVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGP 2566
Query: 3742 CGDNSDEDHCGGKLTYKARPC-----KKDEFAC--SNKKCIPMDLQCDRLDDCGDGSDEQ 3794
C + CGG + R C K C ++++ P LQ C G+D +
Sbjct: 2567 CSVS-----CGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQ-----PCSGGTDCE 2616
Query: 3795 GCRIAPTEYTCEDN-VNPCGDDAYCNQIKTSVF------CRCKPGFQRNMKNRQCEDLNE 3847
R+ + C+ V PC + S CRC PG + + +C L+E
Sbjct: 2617 LGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVEGCRCPPGLL--LHDTRCLPLSE 2674
Query: 3848 C--------------LVFGTCSHQCINVEGSYKC 3867
C + G CS QC+ +G C
Sbjct: 2675 CPCLVGEELKWPGVSFLLGNCS-QCVCEKGELLC 2707
Score = 40.8 bits (94), Expect = 0.031
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 6/58 (10%)
Query: 2874 HSDEAPLNPKCKSAEQS------CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
H + PL + E C C +G C+ GG CD DC DGSDE C
Sbjct: 2211 HHSDVPLQVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 39.7 bits (91), Expect = 0.070
Identities = 19/36 (52%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Query: 1053 CNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC 1088
C G +C G CV CDG DCEDGSDE+GC
Sbjct: 2234 CPGVGLRC-ASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 39.7 bits (91), Expect = 0.070
Identities = 16/28 (57%), Positives = 18/28 (64%)
Query: 3522 CANGDCVSSRFWCDGDFDCADGSDERNC 3549
CA+G+CV CDG DC DGSDE C
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.9 bits (89), Expect = 0.12
Identities = 22/51 (43%), Positives = 24/51 (47%), Gaps = 6/51 (11%)
Query: 958 EMASCE-----FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCV 1003
E+ CE P C P C SG C+ CD DC DGSDE GCV
Sbjct: 2220 ELLGCEPGSPPAPLC-PGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 38.1 bits (87), Expect = 0.20
Identities = 64/309 (20%), Positives = 97/309 (31%), Gaps = 55/309 (17%)
Query: 3356 RCQPGRFQCGTGLCALPAFICD-----GENDCGDNSDELNCDTHVCLSGQFKCTKNQKCI 3410
RC G + G +P CD G + + + C+ C +GQ CT Q C
Sbjct: 4099 RCPKGSLEQDGG--CVPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTA-QPCP 4155
Query: 3411 PVNLRCNGQDDCGDEEDERDCP-ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA 3469
P C P +SC P Q + + S W P+C + ++
Sbjct: 4156 PPT-------HCAWSHWSAWSPCSHSCGPRGQQSRF-RSSTSGSWA----PECREEQSQS 4203
Query: 3470 N-CDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCV 3528
C + +C P Q + + D W + C+ +CT + +C + +C
Sbjct: 4204 QPCPQPSCPPLCLQGTRSRTLGDSWL------------QGECQRCSCTPEGVICEDTECA 4251
Query: 3529 SSR------FWCDGDFDCADGSDERNCETSCSKDQFR---CSNGQCIPAKWKCDG-HEDC 3578
W D C G+ R + R C + C G E C
Sbjct: 4252 VPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPGLLEAC 4311
Query: 3579 KYGEDEKSCEPASPTCSSREYICASDGCISASL--KCNGEY------DCADGSDEMDCVT 3630
+G P +SR C C+ A CN + C G +CV
Sbjct: 4312 SWGPWGPCSRSCGPGLASRSGSCP---CLMAKADPTCNSTFLHLDTQGCYSGPCPEECVW 4368
Query: 3631 ECKEDQFRC 3639
RC
Sbjct: 4369 SSWSSWTRC 4377
Score = 37.4 bits (85), Expect = 0.35
Identities = 45/172 (26%), Positives = 53/172 (30%), Gaps = 33/172 (19%)
Query: 34 PGEFLCHD--HVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
PG L D + TC W C GD C EE+ C C CV
Sbjct: 1342 PGSVLQKDCGNCTCQEGQWHCGGDGG----------HC-EELVPACAEGEALCQENGHCV 1390
Query: 92 HLSQLCNGVLDCPDGYDE----GVHCQELLSNCQQLNC---------QYKCTMVRNSTRC 138
LC+ DC DG DE C E C +C Q C +
Sbjct: 1391 PHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSY 1450
Query: 139 YCEDGFEITEDGRSCKDQDECAVYGTCSQTC--RNTHGSYTC-----SCVEG 183
C G DGR C + C + G TC SCV+G
Sbjct: 1451 PCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDG 1502
Score = 37.0 bits (84), Expect = 0.45
Identities = 18/44 (40%), Positives = 20/44 (45%)
Query: 3348 EPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3391
EP P C +C +G C L CDG DC D SDE C
Sbjct: 2225 EPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 37.0 bits (84), Expect = 0.45
Identities = 14/32 (43%), Positives = 21/32 (65%)
Query: 3769 CSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAP 3800
C++ +C+ CD + DC DGSDE+GC + P
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEEGCVLLP 2272
Score = 37.0 bits (84), Expect = 0.45
Identities = 13/27 (48%), Positives = 19/27 (70%)
Query: 1105 STGRCINKAWVCDGDIDCEDQSDEDDC 1131
++G C+ + CDG +DCED SDE+ C
Sbjct: 2242 ASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 37.0 bits (84), Expect = 0.45
Identities = 14/29 (48%), Positives = 19/29 (65%)
Query: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDE 2542
S+ CG+GEC+ + CD P C+D SDE
Sbjct: 2467 SQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Score = 36.6 bits (83), Expect = 0.59
Identities = 14/35 (40%), Positives = 20/35 (57%)
Query: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC 3587
C RC++G+C+ CDG DC+ G DE+ C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 36.2 bits (82), Expect = 0.77
Identities = 16/41 (39%), Positives = 20/41 (48%)
Query: 837 PGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDED 877
PG +C RC + C+ CDG DC DGSDE+
Sbjct: 2226 PGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEE 2266
Score = 36.2 bits (82), Expect = 0.77
Identities = 102/455 (22%), Positives = 142/455 (31%), Gaps = 114/455 (25%)
Query: 860 ARWKCDGDDDCLDGSDEDSV---NCFN---HSCPD--DQFKCQNN------RCIPKRWLC 905
A+ C+G C + +D+V +C N HSC D D+ +C RC P + +
Sbjct: 4655 AQESCNGGP-CPECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQ 4713
Query: 906 DGA----NDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDRED----------- 950
DG + C +N + Q Q C N C+ + +C ++
Sbjct: 4714 DGRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWS 4773
Query: 951 ----DCGDQTDE----------MASCE--------------FPTCEPLTQFVCKSGRCIS 982
CG T E +A C+ P C P + C
Sbjct: 4774 SCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPECPPGQVLSACATSCPC 4833
Query: 983 SKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINC 1042
WH C + GC C Q +G C+P AC C S +
Sbjct: 4834 LCWHLQPGAICVQEPCQPGC--GCPGGQL-LHNGTCVP-PTAC----PCTQHSLPWGLTL 4885
Query: 1043 TKEE--IHSPAG-----------CNGNEFQCHPDGNCVP--DLWR--CDGEKD-CEDGSD 1084
T EE P G C+G F C VP + W+ GE CE
Sbjct: 4886 TLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLCEQTCL 4945
Query: 1085 EKGCNGTIRLCDHKTKFSC-WSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPC 1143
E T C C G ++A C ED C+ + G P P
Sbjct: 4946 EMNATKTQSNCSSARASGCVCQPGHFRSQAGPC---------VPEDHCECWHLGRPHLPG 4996
Query: 1144 -----ANDTSVCLQPEKLCN---GKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGI 1195
A ++ +CL +C C G +E L G C C
Sbjct: 4997 SEWQEACESCLCLSGRPVCTQHCSPLTCAQG-------EEMVLEPGSCCPSCRREAPEEQ 5049
Query: 1196 VCSCPEGLQLNKDNK-TCEI----VDYCSNHLKCS 1225
SC +L K TC + V YCS + S
Sbjct: 5050 SPSCQLLTELRNFTKGTCYLDQVEVSYCSGYCPSS 5084
Score = 34.7 bits (78), Expect = 2.3
Identities = 60/234 (25%), Positives = 78/234 (33%), Gaps = 63/234 (26%)
Query: 4194 CVCPEGKYLINGTCNDDSLLDDSCKLTCENG------GRCILNEKGDLRC-----HCWPS 4242
C CPEG L G C + + SC CE G G + + G+ C HC
Sbjct: 1312 CFCPEGTLLHGGACLEPA----SC--PCEWGRNSFPPGSVLQKDCGNCTCQEGQWHC--G 1363
Query: 4243 YSGERCE--VNHCSN---YCQNGGTCVP-SVLGRPTCSCALGFTGPNCGKTVCEDFCQNG 4296
G CE V C+ CQ G CVP L C G C C +
Sbjct: 1364 GDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGE----- 1418
Query: 4297 GTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKC 4356
G ++G HC P C + C DG+ E P C
Sbjct: 1419 GQMTCSSG-----HCLP-----------LALLCDRQDDC---GDGTDEPSYPCPQGLLAC 1459
Query: 4357 EVDKC----VRCHG-GHCIINKDSE----DIFC-----NCTNGKIASSCQLCDG 4396
+C + C G C+ D E + C +C +G + QLCDG
Sbjct: 1460 ADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDG 1513
Score = 34.7 bits (78), Expect = 2.3
Identities = 56/241 (23%), Positives = 86/241 (35%), Gaps = 63/241 (26%)
Query: 3277 CMINNGG--CSHL-CLLAPGKTHTCACPTNFYLAADNRTCLS-NCTASQFRCKTDKCIPF 3332
C+ + G CS + C + PG+T P L +TCL N T +Q C + +
Sbjct: 4907 CVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLC--EQTCLEMNATKTQSNCSSARA--- 4961
Query: 3333 WWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICD----GENDCGDNSDE 3388
C CQPG F+ G C +P C+ G + +
Sbjct: 4962 -----------------SGCV---CQPGHFRSQAGPC-VPEDHCECWHLGRPHLPGSEWQ 5000
Query: 3389 LNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKH 3448
C++ +CLSG+ CT Q C P+ C E E SC P C+
Sbjct: 5001 EACESCLCLSGRPVCT--QHCSPLT--------CAQGE-EMVLEPGSCCP---SCRREA- 5045
Query: 3449 CISKLWVCDEDPDCADASDEANCDKKTCGPHEFQC--------KNNNCIPDHWRCDSQND 3500
++ P C ++ N K TC + + + + +P+ SQ D
Sbjct: 5046 ------PEEQSPSCQLLTELRNFTKGTCYLDQVEVSYCSGYCPSSTHVMPEEPYLQSQCD 5099
Query: 3501 C 3501
C
Sbjct: 5100 C 5100
Score = 34.3 bits (77), Expect = 2.9
Identities = 28/89 (31%), Positives = 32/89 (35%), Gaps = 11/89 (12%)
Query: 2534 PHCKDKSDEKLLYCENRSCRRGFKP----------CYNRRCIPHGKLCDGENDCGDNSDE 2583
PH SD L E C G P C + C+ G CDG DC D SDE
Sbjct: 2207 PHDVHHSDVPL-QVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Query: 2584 LDCKVSTCATVEFRCADGTCIPRSARCNQ 2612
C + T F T SA+ Q
Sbjct: 2266 EGCVLLPEGTGRFHSTAKTLALSSAQPGQ 2294
Score = 34.3 bits (77), Expect = 2.9
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 3667
C RC + C+ CDG+ DC DGSDEE C
Sbjct: 2234 CPGVGLRCAS-GECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 33.9 bits (76), Expect = 3.8
Identities = 54/211 (25%), Positives = 69/211 (32%), Gaps = 41/211 (19%)
Query: 4173 PNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEK 4232
P+ C DL CL P C CP G+ + +G C S SC RC L
Sbjct: 4683 PHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGRCVPIS----SC--------RCGLPSA 4730
Query: 4233 GDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
W + +++ CQN TCV L P C + GP + C
Sbjct: 4731 N----ASWELAPAQAVQLD-----CQN-CTCVNESLVCPHQECPV--LGPWSAWSSCSAP 4778
Query: 4293 CQNG-----GTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSE---SCTIGDDGSVE 4344
C G TC G P C Q C C C + +C S
Sbjct: 4779 CGGGTMERHRTCEGGPGVAP-CQAQDTEQRQECNLQPCPE-CPPGQVLSACAT----SCP 4832
Query: 4345 CVCPTRYEGPKCEVDKC---VRCHGGHCIIN 4372
C+C G C + C C GG + N
Sbjct: 4833 CLCWHLQPGAICVQEPCQPGCGCPGGQLLHN 4863
Score = 33.1 bits (74), Expect = 6.5
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 1/55 (1%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCAL 3371
C RC + +C+ CD V DC DGSDE + C GRF AL
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDE-EGCVLLPEGTGRFHSTAKTLAL 2287
Score = 32.7 bits (73), Expect = 8.6
Identities = 21/51 (41%), Positives = 23/51 (45%), Gaps = 12/51 (23%)
Query: 2830 CGDGSDESPQC---GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 2877
C GS +P C G R CA G C+L CDG DC D SDE
Sbjct: 2224 CEPGSPPAPLCPGVGLR--------CASGECVLRGG-PCDGVLDCEDGSDE 2265
Score = 32.7 bits (73), Expect = 8.6
Identities = 14/26 (53%), Positives = 16/26 (61%)
Query: 1012 RCSSGRCIPGHWACDGDNDCGDFSDE 1037
RC+SG C+ CDG DC D SDE
Sbjct: 2240 RCASGECVLRGGPCDGVLDCEDGSDE 2265
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 186 bits (471), Expect = 6e-46
Identities = 105/267 (39%), Positives = 149/267 (55%), Gaps = 12/267 (4%)
Query: 561 LDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
L F +Y+ D T IGR + G E TI++ DL + EGIAVD +G N++WT D +
Sbjct: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT-DSN 1041
Query: 621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAW 680
I VA+L+ R+ L E ++ +PRGIV D V G +YWTDW D +IE ++
Sbjct: 1042 LDRIEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN-----PKIETSY 1094
Query: 681 MDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNH 740
MDG NR+I V + PNGLT D ++ L W DA + E + + R+ G L +
Sbjct: 1095 MDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQY 1152
Query: 741 PFGLSHHGNYVFWTDYMNGSIFQLDLITSEVT--LLRHERPPLFGLQIYDPRKQQGDNMC 798
PF ++ +G +++TD+ S+ LDL S+ T H++ L+G+ + QG N C
Sbjct: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
Query: 799 RVNNGGCSTLCLAIPGGRVCACADNQL 825
VNNGGC+ LCLA PG R C C DN L
Sbjct: 1213 SVNNGGCTHLCLATPGSRTCRCPDNTL 1239
Score = 160 bits (406), Expect = 2e-38
Identities = 97/275 (35%), Positives = 138/275 (50%), Gaps = 28/275 (10%)
Query: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
I L F ++YWTD+ E I G+ S GG ++ L +PEG+ VD + NI+
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSI--GRASLHGGEPT--TIIRQDLGSPEGIAVDHLGRNIF 1036
Query: 1351 WIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
W DSNLD+IEVAKLDG+ R L + +PR I D G L+WTDW+ + P+IE++ M
Sbjct: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
Query: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEII------- 1463
G R+ + +D PNGLT D F ++ W DA GTN E +
Sbjct: 1097 GTNRRILVQD--DLGLPNGLTFDAFSSQLCWVDA-----------GTNRAECLNPSQPSR 1143
Query: 1464 -RGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPS 1522
+ E L +PFAV+ YG +Y+TDW+ N++ + + Q S
Sbjct: 1144 RKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALS 1203
Query: 1523 RQPQAPNPCAANDGKGPCSHMCLINHNRSAACACP 1557
+ PQ N C+ N+ G C+H+CL S C CP
Sbjct: 1204 QCPQGHNYCSVNN--GGCTHLCLATPG-SRTCRCP 1235
Score = 145 bits (366), Expect = 9e-34
Identities = 154/615 (25%), Positives = 242/615 (39%), Gaps = 132/615 (21%)
Query: 2782 DGERDCPDGSDELSTAGCAPNNTC---DENAFMCHNKVCIPKQF-VCDHDDDCGDGSDES 2837
+G D + T GC N C F C + C D+C S++
Sbjct: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDEC---SEQP 718
Query: 2838 PQCGYRQC-----GTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCN 2892
CG GT C +G +Q + C D+ P+N C++ +C+
Sbjct: 719 SVCGSHTICNNHPGTFRCECVEG-------YQFSDEGTCVAVVDQRPIN-YCETGLHNCD 770
Query: 2893 SSFFMCKNGRCIPSGGLCDNKDDC----GDGSDERNCH-INECLSKKVSGCSQD--CQDL 2945
+ + +CI +GG + C G D + C ++EC + S C D C +
Sbjct: 771 ----IPQRAQCIYTGG---SSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDAFCYNT 820
Query: 2946 PVSYKCKCWPGFQLKDDGKTCVD---------------------------------IDEC 2972
P S+ C+C PG+Q DG CV + EC
Sbjct: 821 PGSFTCQCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC 878
Query: 2973 SS-GFPCSQQCINTYGTYKCLCTDGYEIQ-----PDNPNGCKSLSDEEP----------- 3015
+ G QC + G C+ DG E++ P C LS P
Sbjct: 879 DAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPC--LSTVAPPIHQGPAVPTA 936
Query: 3016 --------FLILADHHEIRKISTDGSNY------TLLKQGLNNVIAIDFDYREEFIYWID 3061
L+ A +I ++ +G+ L +I + FD ++ +YW D
Sbjct: 937 VIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTD 996
Query: 3062 SSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGL 3119
+ P+ I R L+G + + + P +AVD +G+N++W+D+ IEV+KL+G
Sbjct: 997 ITEPS---IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGT 1053
Query: 3120 YPTILVSKRLKFPRDLSLDPQAGYLYWIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMA 3178
+L L PR + D G LYW D + P I MDGTN+ ++++ + P
Sbjct: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
Query: 3179 LTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKS 3236
LT D + +L W D N E N R K + + A+T + +Y+TD K S
Sbjct: 1114 LTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA-LEGLQYPFAVTSYGKNLYFTDWKMNS 1172
Query: 3237 -------LSRAHKTSGADRLSLIYS-WHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLC 3288
+S+ + + +Y A++ H+Y C +NNGGC+HLC
Sbjct: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNY---------CSVNNGGCTHLC 1223
Query: 3289 LLAPGKTHTCACPTN 3303
L PG + TC CP N
Sbjct: 1224 LATPG-SRTCRCPDN 1237
Score = 131 bits (329), Expect = 2e-29
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 9/275 (3%)
Query: 1913 VGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDH 1972
+G+ F + +YWTD+ I RA II LG EGIAVD + NI+WTD
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 1973 GFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEK 2031
+ IEVA+L+G+ R V+ L PR I +G L+WT+W + P I + +DG+ +
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 2032 VVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAV 2091
+LV + PNG++ D ++L W DA T++ E ++ + +R L G F+V
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLN-PSQPSRRKALEGLQYP-FAVTS 1158
Query: 2092 FGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDN 2151
+G +Y++D SV + ET + L + +G N C+ +N
Sbjct: 1159 YGKNLYFTD--WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
Query: 2152 GGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHE 2186
GGC LCL S RTC C L GV C+ +
Sbjct: 1217 GGCTHLCLATPGS-RTCRCPDNTL---GVDCIEQK 1247
Score = 126 bits (316), Expect = 6e-28
Identities = 85/260 (32%), Positives = 129/260 (49%), Gaps = 21/260 (8%)
Query: 1613 FDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDE 1672
FD ++ +YWTDI +I RA ++G T+I +D+ S G+AVD + RN++W S D
Sbjct: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD- 1043
Query: 1673 TQINVARLDGSLKTSIIH-GIDKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKI 1727
+I VA+LDG+ + + + P+ + VRG LYWTD N I + MDG+N +I
Sbjct: 1044 -RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRI 1102
Query: 1728 LFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIM 1786
L Q+ P GL+ D ++L W+ +G NR + E L A+T
Sbjct: 1103 LVQDDLGLPNGLTFDAFSSQLCWVDAGT---NRAECLNPSQPSRRKALEGLQYPFAVTSY 1159
Query: 1787 DKKLWWADQNL-----AQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLN 1841
K L++ D + L + D P +K + + + + QG N C +N
Sbjct: 1160 GKNLYFTDWKMNSVVALDLAISKETDAFQP----HKQTRLYGITTALSQCPQGHNYCSVN 1215
Query: 1842 NGGCSQLCLPTSETTRTCMC 1861
NGGC+ LCL T +RTC C
Sbjct: 1216 NGGCTHLCLAT-PGSRTCRC 1234
Score = 94.0 bits (232), Expect = 3e-18
Identities = 66/273 (24%), Positives = 123/273 (45%), Gaps = 19/273 (6%)
Query: 2222 KNVIALAFDYNQRRKGTNRIFYSDAHFGNI-QLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
K +I LAFD + ++++D +I + E +I +++GS EG+A
Sbjct: 978 KVIIGLAFDCVDKM-----VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
Query: 2281 DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
++WT S I +D T+ V+ ++ +P + D + ++WT+WN
Sbjct: 1033 RNIFWTDSNLDRIEVAKLDGTQ------RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 1086
Query: 2341 HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
+P I S + G N +++V D+ PNGLT D + +L + D + E R
Sbjct: 1087 NPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
Query: 2401 VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT 2460
++ F ++ Y ++++DW +++ + +T + PH+ + +
Sbjct: 1147 LEGLQYPF-AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGITTAL 1202
Query: 2461 NSCEL--SPCALLNGGCHDLCLLTPNGRVNCSC 2491
+ C + C++ NGGC LCL TP R C C
Sbjct: 1203 SQCPQGHNYCSVNNGGCTHLCLATPGSR-TCRC 1234
Score = 89.0 bits (219), Expect = 1e-16
Identities = 114/468 (24%), Positives = 180/468 (38%), Gaps = 89/468 (19%)
Query: 103 CPDGYD-EGVHCQELLSNCQQLNCQYK--CTMVRNSTRCYCEDGFEITEDGRSCKDQD-- 157
C G+ +G CQ++ CQ C C S C C+ G++ DG C +
Sbjct: 789 CLPGFSGDGQACQDV-DECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEVE 845
Query: 158 -------------------------------ECAVYGTCSQTCRNTHGSYT-CSCVEGYL 185
EC +G + T HGS C CV+
Sbjct: 846 KTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPT--QCHGSTGYCWCVDRDG 903
Query: 186 MQPDNRSCKAKIEP----TDRPPI------------------LLIANFETIEVFYLNGSK 223
+ + + + P T PPI LL A IE L G+
Sbjct: 904 REVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT 963
Query: 224 MATLSS-----VNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
M + V I L F + M+ W + E S I +A E T I
Sbjct: 964 MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-------IGRASLHGGEPTTII 1016
Query: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
Q + + +A+D L RN+++ D DRI V +G+ L + +L NP+ I D + G
Sbjct: 1017 RQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRG 1076
Query: 339 KLFFTDYG-NVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 397
L++TD+ + K+E MDG NR ++ P L D + + WVD + +
Sbjct: 1077 NLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECL 1136
Query: 398 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR--FNGTDIHSLIKIEN 455
+ +R ++G Q + + +T + LY T+ ++V ++ TD K
Sbjct: 1137 NPSQPSRRKALEGLQ--YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR 1194
Query: 456 AWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
+GI +Q + C V+ GGC+H+CL + +RTCRC
Sbjct: 1195 LYGIT--TALSQCPQGHNYCSVN----NGGCTHLCLATPG--SRTCRC 1234
Score = 77.0 bits (188), Expect = 4e-13
Identities = 79/288 (27%), Positives = 109/288 (37%), Gaps = 62/288 (21%)
Query: 3933 DMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMH 3992
D +++ T I +HG E + +I + P IAVD + NI+WTD +
Sbjct: 989 DKMVYWTDITEPSIGRASLHGGEP----TTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
Query: 3993 WFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSH 4051
I V +L+G L P I + RG +YWT D+
Sbjct: 1045 ---------------IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPK 1089
Query: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
IE + MDGT RRILVQ +L P GL D FS ++ W D G+N ++
Sbjct: 1090 IETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVD-----------AGTNRAECLNP 1138
Query: 4112 KQ--------GLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLI 4163
Q GL +P + + +Y K SV L L I K
Sbjct: 1139 SQPSRRKALEGLQYPFAVTSYGKNLYFTDWK----------MNSVVALDLAISKETDAFQ 1188
Query: 4164 SHRYKQL--------DLP---NPCL--DLACEFLCLLNPSGATCVCPE 4198
H+ +L P N C + C LCL P TC CP+
Sbjct: 1189 PHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
Score = 55.8 bits (133), Expect = 9e-07
Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 1/111 (0%)
Query: 553 ENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNN 612
++L +P + I++ D+ I K+DGT+R + + DL N GI D + N
Sbjct: 1018 QDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN 1077
Query: 613 LYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTD 663
LYWT D +R + +R+ L++ ++ P G+ D + + W D
Sbjct: 1078 LYWT-DWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Score = 49.7 bits (117), Expect = 7e-05
Identities = 48/150 (32%), Positives = 64/150 (42%), Gaps = 43/150 (28%)
Query: 66 LDTCPEEVEIKCPLNHIACL---GTNKCVHLSQLCNGVLDCPDGY---DEGV-------- 111
+D C E+ + C +H C GT +C +C +GY DEG
Sbjct: 711 IDECSEQPSV-CG-SHTICNNHPGTFRC-----------ECVEGYQFSDEGTCVAVVDQR 757
Query: 112 ---HCQELLSNC---QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTC 165
+C+ L NC Q+ C Y +S C C GF + DG++C+D DEC C
Sbjct: 758 PINYCETGLHNCDIPQRAQCIYTGG---SSYTCSCLPGF--SGDGQACQDVDECQP-SRC 811
Query: 166 SQT--CRNTHGSYTCSCVEGYLMQPDNRSC 193
C NT GS+TC C GY Q D C
Sbjct: 812 HPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
Score = 47.4 bits (111), Expect = 3e-04
Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 4/95 (4%)
Query: 1165 DGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK- 1223
+GS + L + C + GC + + PG +C + D +TC +D CS
Sbjct: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
Query: 1224 CSQ--VCEQHKHTVKCSCYEGWKLDVDGESCTSVD 1256
C +C H T +C C EG++ +G VD
Sbjct: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
Score = 45.4 bits (106), Expect = 0.001
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 133 RNSTRCYCEDGFEITEDGRSCKDQDECAVY-GTCSQ--TCRNTHGSYTCSCVEGYLMQPD 189
R C C GF DGR+C D DEC+ C C N G++ C CVEGY D
Sbjct: 690 RTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-D 746
Query: 190 NRSCKAKIE 198
+C A ++
Sbjct: 747 EGTCVAVVD 755
Score = 41.2 bits (95), Expect = 0.024
Identities = 46/179 (25%), Positives = 65/179 (36%), Gaps = 33/179 (18%)
Query: 3721 HRCRNNRICL---QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCI-- 3775
H C N C +++ C EC D G+ Y C + C +
Sbjct: 677 HGCDTNAACRPGPRTQFTC----ECSIGFRGD---GRTCYDIDECSEQPSVCGSHTICNN 729
Query: 3776 -PMDLQCDRLDDCGDG---SDEQGCRIA----PTEYTCEDNVNPCGDDAYCNQIKT---S 3824
P +C+ C +G SDE C P Y CE ++ C I T S
Sbjct: 730 HPGTFRCE----CVEGYQFSDEGTCVAVVDQRPINY-CETGLHNCDIPQRAQCIYTGGSS 784
Query: 3825 VFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQ--CINVEGSYKCVCDQNFQERNNTCI 3881
C C PGF + + C+D++EC C C N GS+ C C +Q C+
Sbjct: 785 YTCSCLPGFSGD--GQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Score = 40.8 bits (94), Expect = 0.031
Identities = 47/184 (25%), Positives = 62/184 (33%), Gaps = 59/184 (32%)
Query: 4257 CQNGGTCVPSVLGRPTCSCALGFTGPN---------------CGK-TVCEDF-------C 4293
C C P + TC C++GF G CG T+C + C
Sbjct: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
Query: 4294 QNG------GTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYC--VNSESCTIGDDGSVEC 4345
G GTC+ +P +C+ TG H C C S C
Sbjct: 739 VEGYQFSDEGTCVAVVDQRPINYCE---TG--------LHNCDIPQRAQCIYTGGSSYTC 787
Query: 4346 VCPTRY--EGPKC-EVDKC--VRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYN 4400
C + +G C +VD+C RCH D FC T G +CQ GY +
Sbjct: 788 SCLPGFSGDGQACQDVDECQPSRCH----------PDAFCYNTPGSF--TCQCKPGYQGD 835
Query: 4401 GGTC 4404
G C
Sbjct: 836 GFRC 839
Score = 39.7 bits (91), Expect = 0.070
Identities = 52/219 (23%), Positives = 77/219 (35%), Gaps = 62/219 (28%)
Query: 4184 LCLLNPSGATCVCPEG-KYLINGTCNDDSLLDDSCKLTCENG---------GRCILNEKG 4233
+C +P C C EG ++ GTC +++D CE G +CI
Sbjct: 726 ICNNHPGTFRCECVEGYQFSDEGTCV--AVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
Query: 4234 DLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFC 4293
C C P +SG+ CQ+ C PS C
Sbjct: 784 SYTCSCLPGFSGD-------GQACQDVDECQPS-------------------------RC 811
Query: 4294 QNGGTCIVTAGNQPYCHCQPEYTGD--RC-QYYVCHHYCVNSESCTIGDDGSVECVCPTR 4350
C T G+ C C+P Y GD RC V C + +G G+ + P R
Sbjct: 812 HPDAFCYNTPGSFT-CQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATD---PQR 867
Query: 4351 YEGPKCEVDKC--------VRCHG--GHC-IINKDSEDI 4378
P V +C +CHG G+C +++D ++
Sbjct: 868 PIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 906
Score = 38.5 bits (88), Expect = 0.16
Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Query: 1736 VGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQ 1795
+GL+ D V+ +YW +I R +L GG I + A+ + + ++W D
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 1796 NLAQLGTCSKRDGRNPTIL 1814
NL ++ +K DG +L
Sbjct: 1041 NLDRI-EVAKLDGTQRRVL 1058
Score = 35.4 bits (80), Expect = 1.3
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 1163 CPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPE 1201
CP G + CS+NNGGC++ C PG C CP+
Sbjct: 1205 CPQGHNY------CSVNNGGCTHLCLATPG-SRTCRCPD 1236
Score = 33.1 bits (74), Expect = 6.5
Identities = 48/190 (25%), Positives = 66/190 (34%), Gaps = 31/190 (16%)
Query: 3270 PDVSKHLCMINNGGC--SHLCLLAPGKTHTCACPTNFYLAADNRTC--LSNCTASQFRCK 3325
PD ++ C I GC + C P TC C F D RTC + C+ C
Sbjct: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCG 722
Query: 3326 TDKCI---PFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGL--CALPAFICDGEN 3380
+ P ++C+ V+ G + C Q C TGL C +P
Sbjct: 723 SHTICNNHPGTFRCECVE--GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQ-----RA 775
Query: 3381 DC---GDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS 3437
C G +S +C GQ C +C P RC+ C + C C
Sbjct: 776 QCIYTGGSSYTCSCLPGFSGDGQ-ACQDVDECQP--SRCHPDAFCYNTPGSFTC---QCK 829
Query: 3438 PDY----FQC 3443
P Y F+C
Sbjct: 830 PGYQGDGFRC 839
Score = 33.1 bits (74), Expect = 6.5
Identities = 36/145 (24%), Positives = 52/145 (35%), Gaps = 32/145 (22%)
Query: 804 GCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRC---KNRHCIQ- 859
G T+C PG C C + + G TC + + C+ G C + CI
Sbjct: 722 GSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
Query: 860 --ARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE 917
+ + C CL G D C D +CQ +RC P + +
Sbjct: 781 GGSSYTC----SCLPGFSGDGQAC------QDVDECQPSRCHPDAFCYN----------- 819
Query: 918 SNQTCTARTCQVDQFSCGNG-RCIP 941
T + TCQ G+G RC+P
Sbjct: 820 ---TPGSFTCQCKPGYQGDGFRCVP 841
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 161 bits (407), Expect = 2e-38
Identities = 87/230 (37%), Positives = 133/230 (57%), Gaps = 5/230 (2%)
Query: 1924 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 1983
+YWTD I RA D + + +I + + IAV+W+A ++YWT G IEV LN
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1984 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 2043
+ +++S+ +D+PR+IA+HPE GL +W +WG+ P I +A LD E VLV+ + WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 2044 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAH 2103
G+++D +E KLYW DA+TDKIE I ++ R+ +L +F + G +IYW+ A
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWT--AW 181
Query: 2104 ANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGG 2153
+ S++R HK A + + +L +K N + GTN A NGG
Sbjct: 182 QHHSIKRVHKVKANRDVII--DQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
Score = 130 bits (327), Expect = 3e-29
Identities = 75/245 (30%), Positives = 128/245 (52%), Gaps = 10/245 (4%)
Query: 569 YIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVAR 628
++Y+ D + I R +DG+ +T++ +++ + IAV+W+ +LYWT+ G + I V
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTC 62
Query: 629 LEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQI 688
L S S K L+ +M PR I + P G YW DW E+ I++A +D ++
Sbjct: 63 LN--STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP------EIKRANLDRQELRV 114
Query: 689 FVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG 748
V + + WPNGL LD LYW DA D IE + ++ T R+ + + L H F + G
Sbjct: 115 LVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK-LPHIFRFTLLG 173
Query: 749 NYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTL 808
++++WT + + SI ++ + + ++ + P L GL+ + K G N NGG +T
Sbjct: 174 DFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATC 233
Query: 809 CLAIP 813
+ P
Sbjct: 234 ASSRP 238
Score = 118 bits (295), Expect = 2e-25
Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 7/193 (3%)
Query: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRII 3111
E +YW D I R L+GS + + NT + P+ +AV+W+ ++LYW+ T I
Sbjct: 2 EGHVYWTDDEV---WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHI 58
Query: 3112 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 3171
EV+ LN ILVS+ + PR ++L P+ G YWID E P I R +D V++
Sbjct: 59 EVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNA 118
Query: 3172 KISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229
+ P L +D +LYW D + IE ++D + R + +P + TL D+IYW
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYW 178
Query: 3230 TDGKTKSLSRAHK 3242
T + S+ R HK
Sbjct: 179 TAWQHHSIKRVHK 191
Score = 114 bits (285), Expect = 2e-24
Identities = 61/196 (31%), Positives = 103/196 (52%), Gaps = 9/196 (4%)
Query: 1302 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1361
+YWTD I R L SG + I + P+ + V+W+A ++YW + + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKIND----PDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1362 AKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDM 1421
L+ + L++ M+ PRAIAL P G+ +W DW N P I+ A++ + +
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVLVN-- 117
Query: 1422 KTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE 1481
+ WPNGL +D E ++ W DA++D I + D T +++ + L H F +L G
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
Query: 1482 VYWTDWRTNTLSKANK 1497
+YWT W+ +++ + +K
Sbjct: 176 IYWTAWQHHSIKRVHK 191
Score = 95.5 bits (236), Expect = 1e-18
Identities = 60/234 (25%), Positives = 113/234 (48%), Gaps = 8/234 (3%)
Query: 1617 EERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQIN 1676
E +YWTD + I+RA+++G+G +T+I+ I +AV+WV+R+LYW + + ++
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 1677 VARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGSNSKILFQ-NQ 1732
S K + +D+P+ +A HP G YW D I AN+D ++L +
Sbjct: 62 CLN-STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 1733 KEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792
P GL++D E KLYW + I ++D + + +K++L T++ ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIYW 178
Query: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCS 1846
+ K N ++ ++ ++ +K + + G+N NGG +
Sbjct: 179 TAWQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
Score = 82.8 bits (203), Expect = 7e-15
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 18/181 (9%)
Query: 3963 LICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022
LI + P DIAV+WVA ++YWT H I V LN + L+
Sbjct: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEH---------------IEVTCLNSTSHKILV 72
Query: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFS 4082
+ EP AIA++P+ G+ YW G++ I+ A +D R+LV +L P GLA+D
Sbjct: 73 SEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQE 132
Query: 4083 ERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRVQ 4141
++YW D + I ++ D + + K L H R + D+IY A + + RV
Sbjct: 133 GKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPHIFRFTLLGDFIYWTAWQHHSIKRVH 190
Query: 4142 K 4142
K
Sbjct: 191 K 191
Score = 80.5 bits (197), Expect = 4e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 12/213 (5%)
Query: 2263 VIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSED-DHPH 2321
+I + + +A + +LYWT + T I ++ T I +SED D P
Sbjct: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNST-------SHKILVSEDMDEPR 80
Query: 2322 VLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSD 2381
+AL L +W +W E +P I R+ L + +V+V+ + PNGL +D + KLY+ D
Sbjct: 81 AIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGD 139
Query: 2382 GSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKI 2441
KIE D ++R ++K + ++I+W+ W +I R +K I
Sbjct: 140 AKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVI 199
Query: 2442 LRSDIPHQPMGIIAVANDTNSCELSPCALLNGG 2474
+ D MG+ AV N +P A NGG
Sbjct: 200 I--DQLPDLMGLKAV-NVDKVVGTNPHADRNGG 229
Score = 75.1 bits (183), Expect = 2e-12
Identities = 38/154 (24%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Query: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
+A++W+ R+LY+ + I V N + L+ ++ P+AIA+ P G ++ D+G
Sbjct: 39 IAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE 98
Query: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407
+++R ++D ++++ P LALDL +YW D D + + R T+
Sbjct: 99 NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL 158
Query: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR 441
++ + + H++ T+ D++Y T +++I R+++
Sbjct: 159 LKDK-LPHIFRFTLLGDFIYWTAWQHHSIKRVHK 191
Score = 55.8 bits (133), Expect = 9e-07
Identities = 35/123 (28%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 655 VNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDA 714
+ G +YWTD D V I +A++DG Q + +K+ P+ + +++ +LYW
Sbjct: 1 MEGHVYWTD-------DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT 53
Query: 715 YYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG--NYVFWTDY-MNGSIFQLDLITSEV 771
+HIE LN T KI+ S +++ P ++ H +W D+ N I + +L E+
Sbjct: 54 GTEHIEVTCLNSTSHKILVS-EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
Query: 772 TLL 774
+L
Sbjct: 113 RVL 115
Score = 50.1 bits (118), Expect = 5e-05
Identities = 44/180 (24%), Positives = 71/180 (39%), Gaps = 29/180 (16%)
Query: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040
G++YWTD ++I L+G L+ +P IAVN
Sbjct: 3 GHVYWTDDEV---------------WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARS 47
Query: 4041 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF-ELSIIGSVL 4099
+YWT G HIE ++ T +ILV +++ P +A+ YW D+ E I
Sbjct: 48 LYWTHTGT-EHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRAN 106
Query: 4100 YDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTK 4159
D V V++ G + +D+ E +Y K A+++D+TK
Sbjct: 107 LDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIE------------AISVDETK 154
Score = 47.4 bits (111), Expect = 3e-04
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 553 ENLVNPRALDFHAETNYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611
E++ PRA+ H E Y+ D + I R +D E ++ L G+A+D
Sbjct: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
Query: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEI 669
LYW G KT + + R+TLL+ ++ H + + ++YWT W+ I
Sbjct: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSI 186
Score = 43.5 bits (101), Expect = 0.005
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 12/118 (10%)
Query: 2256 DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMS 2315
D E R ++ ++G GLA LYW + T I +VD+T+ T+
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQ--------TLL 159
Query: 2316 EDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVS--TDILTPNGLTID 2371
+D PH+ + ++WT W QH SI R N V++ D++ + +D
Sbjct: 160 KDKLPHIFRFTLLGDFIYWTAW--QHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVD 215
Score = 38.5 bits (88), Expect = 0.16
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 558 PRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTN 617
P L + +Y+ D + I +D T+R+T+LKD L ++ + +G+ +YWT
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTA 180
Query: 618 DGHRKTINVARLEKASQSRKTLLE--GEMSHPRGIVVDPVNG 657
H ++ R+ K +R +++ ++ + + VD V G
Sbjct: 181 WQHH---SIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
Score = 33.9 bits (76), Expect = 3.8
Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 8/123 (6%)
Query: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAI 1449
G ++WTD + I A + G+G +T+ P+ + V+ + + WT ++ I
Sbjct: 3 GHVYWTDDEVW--AIRRAYLDGSGAQTLINTKIND--PDDIAVNWVARSLYWTHTGTEHI 58
Query: 1450 YSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE--VYWTDWRTNTLSKANKWTGQNVSVIQ 1507
+ T+ ++ E + P A++L+ YW DW N K Q + V+
Sbjct: 59 EVTCLNSTSHKILVS--EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLV 116
Query: 1508 KTS 1510
S
Sbjct: 117 NAS 119
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 161 bits (407), Expect = 2e-38
Identities = 87/230 (37%), Positives = 133/230 (57%), Gaps = 5/230 (2%)
Query: 1924 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 1983
+YWTD I RA D + + +I + + IAV+W+A ++YWT G IEV LN
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1984 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 2043
+ +++S+ +D+PR+IA+HPE GL +W +WG+ P I +A LD E VLV+ + WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 2044 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAH 2103
G+++D +E KLYW DA+TDKIE I ++ R+ +L +F + G +IYW+ A
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWT--AW 181
Query: 2104 ANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGG 2153
+ S++R HK A + + +L +K N + GTN A NGG
Sbjct: 182 QHHSIKRVHKVKANRDVII--DQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
Score = 130 bits (327), Expect = 3e-29
Identities = 75/245 (30%), Positives = 128/245 (52%), Gaps = 10/245 (4%)
Query: 569 YIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVAR 628
++Y+ D + I R +DG+ +T++ +++ + IAV+W+ +LYWT+ G + I V
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTC 62
Query: 629 LEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQI 688
L S S K L+ +M PR I + P G YW DW E+ I++A +D ++
Sbjct: 63 LN--STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP------EIKRANLDRQELRV 114
Query: 689 FVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG 748
V + + WPNGL LD LYW DA D IE + ++ T R+ + + L H F + G
Sbjct: 115 LVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK-LPHIFRFTLLG 173
Query: 749 NYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTL 808
++++WT + + SI ++ + + ++ + P L GL+ + K G N NGG +T
Sbjct: 174 DFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATC 233
Query: 809 CLAIP 813
+ P
Sbjct: 234 ASSRP 238
Score = 118 bits (295), Expect = 2e-25
Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 7/193 (3%)
Query: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRII 3111
E +YW D I R L+GS + + NT + P+ +AV+W+ ++LYW+ T I
Sbjct: 2 EGHVYWTDDEV---WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHI 58
Query: 3112 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 3171
EV+ LN ILVS+ + PR ++L P+ G YWID E P I R +D V++
Sbjct: 59 EVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNA 118
Query: 3172 KISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229
+ P L +D +LYW D + IE ++D + R + +P + TL D+IYW
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYW 178
Query: 3230 TDGKTKSLSRAHK 3242
T + S+ R HK
Sbjct: 179 TAWQHHSIKRVHK 191
Score = 114 bits (285), Expect = 2e-24
Identities = 61/196 (31%), Positives = 103/196 (52%), Gaps = 9/196 (4%)
Query: 1302 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1361
+YWTD I R L SG + I + P+ + V+W+A ++YW + + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKIND----PDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1362 AKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDM 1421
L+ + L++ M+ PRAIAL P G+ +W DW N P I+ A++ + +
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVLVN-- 117
Query: 1422 KTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE 1481
+ WPNGL +D E ++ W DA++D I + D T +++ + L H F +L G
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
Query: 1482 VYWTDWRTNTLSKANK 1497
+YWT W+ +++ + +K
Sbjct: 176 IYWTAWQHHSIKRVHK 191
Score = 95.5 bits (236), Expect = 1e-18
Identities = 60/234 (25%), Positives = 113/234 (48%), Gaps = 8/234 (3%)
Query: 1617 EERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQIN 1676
E +YWTD + I+RA+++G+G +T+I+ I +AV+WV+R+LYW + + ++
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 1677 VARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGSNSKILFQ-NQ 1732
S K + +D+P+ +A HP G YW D I AN+D ++L +
Sbjct: 62 CLN-STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 1733 KEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792
P GL++D E KLYW + I ++D + + +K++L T++ ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIYW 178
Query: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCS 1846
+ K N ++ ++ ++ +K + + G+N NGG +
Sbjct: 179 TAWQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
Score = 82.8 bits (203), Expect = 7e-15
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 18/181 (9%)
Query: 3963 LICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022
LI + P DIAV+WVA ++YWT H I V LN + L+
Sbjct: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEH---------------IEVTCLNSTSHKILV 72
Query: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFS 4082
+ EP AIA++P+ G+ YW G++ I+ A +D R+LV +L P GLA+D
Sbjct: 73 SEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQE 132
Query: 4083 ERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRVQ 4141
++YW D + I ++ D + + K L H R + D+IY A + + RV
Sbjct: 133 GKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPHIFRFTLLGDFIYWTAWQHHSIKRVH 190
Query: 4142 K 4142
K
Sbjct: 191 K 191
Score = 80.5 bits (197), Expect = 4e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 12/213 (5%)
Query: 2263 VIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSED-DHPH 2321
+I + + +A + +LYWT + T I ++ T I +SED D P
Sbjct: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNST-------SHKILVSEDMDEPR 80
Query: 2322 VLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSD 2381
+AL L +W +W E +P I R+ L + +V+V+ + PNGL +D + KLY+ D
Sbjct: 81 AIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGD 139
Query: 2382 GSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKI 2441
KIE D ++R ++K + ++I+W+ W +I R +K I
Sbjct: 140 AKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVI 199
Query: 2442 LRSDIPHQPMGIIAVANDTNSCELSPCALLNGG 2474
+ D MG+ AV N +P A NGG
Sbjct: 200 I--DQLPDLMGLKAV-NVDKVVGTNPHADRNGG 229
Score = 75.1 bits (183), Expect = 2e-12
Identities = 38/154 (24%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Query: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
+A++W+ R+LY+ + I V N + L+ ++ P+AIA+ P G ++ D+G
Sbjct: 39 IAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE 98
Query: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407
+++R ++D ++++ P LALDL +YW D D + + R T+
Sbjct: 99 NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL 158
Query: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR 441
++ + + H++ T+ D++Y T +++I R+++
Sbjct: 159 LKDK-LPHIFRFTLLGDFIYWTAWQHHSIKRVHK 191
Score = 55.8 bits (133), Expect = 9e-07
Identities = 35/123 (28%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 655 VNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDA 714
+ G +YWTD D V I +A++DG Q + +K+ P+ + +++ +LYW
Sbjct: 1 MEGHVYWTD-------DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT 53
Query: 715 YYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG--NYVFWTDY-MNGSIFQLDLITSEV 771
+HIE LN T KI+ S +++ P ++ H +W D+ N I + +L E+
Sbjct: 54 GTEHIEVTCLNSTSHKILVS-EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
Query: 772 TLL 774
+L
Sbjct: 113 RVL 115
Score = 50.1 bits (118), Expect = 5e-05
Identities = 44/180 (24%), Positives = 71/180 (39%), Gaps = 29/180 (16%)
Query: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040
G++YWTD ++I L+G L+ +P IAVN
Sbjct: 3 GHVYWTDDEV---------------WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARS 47
Query: 4041 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF-ELSIIGSVL 4099
+YWT G HIE ++ T +ILV +++ P +A+ YW D+ E I
Sbjct: 48 LYWTHTGT-EHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRAN 106
Query: 4100 YDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTK 4159
D V V++ G + +D+ E +Y K A+++D+TK
Sbjct: 107 LDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIE------------AISVDETK 154
Score = 47.4 bits (111), Expect = 3e-04
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 553 ENLVNPRALDFHAETNYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611
E++ PRA+ H E Y+ D + I R +D E ++ L G+A+D
Sbjct: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
Query: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEI 669
LYW G KT + + R+TLL+ ++ H + + ++YWT W+ I
Sbjct: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSI 186
Score = 43.5 bits (101), Expect = 0.005
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 12/118 (10%)
Query: 2256 DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMS 2315
D E R ++ ++G GLA LYW + T I +VD+T+ T+
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQ--------TLL 159
Query: 2316 EDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVS--TDILTPNGLTID 2371
+D PH+ + ++WT W QH SI R N V++ D++ + +D
Sbjct: 160 KDKLPHIFRFTLLGDFIYWTAW--QHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVD 215
Score = 38.5 bits (88), Expect = 0.16
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 558 PRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTN 617
P L + +Y+ D + I +D T+R+T+LKD L ++ + +G+ +YWT
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTA 180
Query: 618 DGHRKTINVARLEKASQSRKTLLE--GEMSHPRGIVVDPVNG 657
H ++ R+ K +R +++ ++ + + VD V G
Sbjct: 181 WQHH---SIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
Score = 33.9 bits (76), Expect = 3.8
Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 8/123 (6%)
Query: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAI 1449
G ++WTD + I A + G+G +T+ P+ + V+ + + WT ++ I
Sbjct: 3 GHVYWTDDEVW--AIRRAYLDGSGAQTLINTKIND--PDDIAVNWVARSLYWTHTGTEHI 58
Query: 1450 YSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE--VYWTDWRTNTLSKANKWTGQNVSVIQ 1507
+ T+ ++ E + P A++L+ YW DW N K Q + V+
Sbjct: 59 EVTCLNSTSHKILVS--EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLV 116
Query: 1508 KTS 1510
S
Sbjct: 117 NAS 119
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 149 bits (377), Expect = 5e-35
Identities = 88/229 (38%), Positives = 110/229 (48%), Gaps = 27/229 (11%)
Query: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCN-GQDDCGDE 3425
G C +GE CG+ S QF T N I V + D G
Sbjct: 395 GTCPKDYVEINGEKYCGERS-------------QFVVTSNSNKITVRFHSDQSYTDTGFL 441
Query: 3426 EDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGP-HEFQCK 3484
+ + P F C+T + CI K CD DC D SDE NC +C H+F CK
Sbjct: 442 AEYLSYDSSDPCPGQFTCRTGR-CIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCK 497
Query: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
N C P W CDS NDC DNSDE+ C +C + F C+NG C+S C+G DC DGS
Sbjct: 498 NKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGS 554
Query: 3545 DERNCE----TSCSKDQFRCSNGQCI-PAKWKCDGHEDCKYGEDEKSCE 3588
DE +C +C+K +RC NG C+ +CDG EDC G DEK C+
Sbjct: 555 DEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 131 bits (329), Expect = 2e-29
Identities = 76/179 (42%), Positives = 96/179 (53%), Gaps = 22/179 (12%)
Query: 3347 DEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSG-QFKCTK 3405
D D CP G+F C TG C CDG DC D+SDELNC C +G QF C K
Sbjct: 448 DSSDPCP------GQFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTC-K 497
Query: 3406 NQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADA 3465
N+ C P+ C+ +DCGD DE+ C SC F+C K C+SK C+ DC D
Sbjct: 498 NKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGK-CLSKSQQCNGKDDCGDG 553
Query: 3466 SDEANCDK---KTCGPHEFQCKNNNCI-PDHWRCDSQNDCSDNSDEENCKPQTCTLKDF 3520
SDEA+C K TC H ++C N C+ + CD + DCSD SDE++C C L+ F
Sbjct: 554 SDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC---DCGLRSF 609
Score = 130 bits (326), Expect = 4e-29
Identities = 70/160 (43%), Positives = 90/160 (56%), Gaps = 17/160 (10%)
Query: 848 GEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCP-DDQFKCQNNRCIPKRWLCD 906
G+F C+ CI+ +CDG DC D SDE +NC SC QF C+N C P W+CD
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDE--LNC---SCDAGHQFTCKNKFCKPLFWVCD 509
Query: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASC---E 963
NDCG N DE +C A+T F C NG+C+ ++ C+ +DDCGD +DE ASC
Sbjct: 510 SVNDCGDNSDEQGCSCPAQT-----FRCSNGKCLSKSQQCNGKDDCGDGSDE-ASCPKVN 563
Query: 964 FPTCEPLTQFVCKSGRCIS-SKWHCDSDDDCGDGSDEVGC 1002
TC T + C +G C+S CD +DC DGSDE C
Sbjct: 564 VVTCTKHT-YRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 129 bits (325), Expect = 5e-29
Identities = 75/169 (44%), Positives = 96/169 (56%), Gaps = 23/169 (13%)
Query: 931 QFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSD 990
QF+C GRCI + CD DC D +DE+ +C +C+ QF CK+ C W CDS
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDEL-NC---SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 991 DDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQ------INCTK 1044
+DCGD SDE GC SC FRCS+G+C+ C+G +DCGD SDEA + CTK
Sbjct: 512 NDCGDNSDEQGC--SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTK 569
Query: 1045 EEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIR 1093
H+ NG C GN P+ CDG++DC DGSDEK C+ +R
Sbjct: 570 ---HTYRCLNG---LCLSKGN--PE---CDGKEDCSDGSDEKDCDCGLR 607
Score = 125 bits (315), Expect = 7e-28
Identities = 77/248 (31%), Positives = 105/248 (42%), Gaps = 36/248 (14%)
Query: 3428 ERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQC-KNN 3486
E P +C DY + K+C + + +N +K T H Q +
Sbjct: 389 EPGVPAGTCPKDYVEINGEKYCGER----------SQFVVTSNSNKITVRFHSDQSYTDT 438
Query: 3487 NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE 3546
+ ++ DS + C F C G C+ CDG DC D SDE
Sbjct: 439 GFLAEYLSYDSSDPCPGQ---------------FTCRTGRCIRKELRCDGWADCTDHSDE 483
Query: 3547 RNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGC 3606
NC QF C N C P W CD DC DE+ C +C ++ + C++ C
Sbjct: 484 LNCSCDAGH-QFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKC 537
Query: 3607 ISASLKCNGEYDCADGSDEMDC----VTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGS 3662
+S S +CNG+ DC DGSDE C V C + +RC N CDG DC DGS
Sbjct: 538 LSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGS 597
Query: 3663 DEENCERG 3670
DE++C+ G
Sbjct: 598 DEKDCDCG 605
Score = 125 bits (315), Expect = 7e-28
Identities = 75/215 (34%), Positives = 106/215 (49%), Gaps = 12/215 (5%)
Query: 3540 CADGSDERNCETSCS-KDQFRC-SNGQCIPAKWKCD-GHEDCKYGEDEKSCEPASPTCSS 3596
C E N E C + QF SN I ++ D + D + + S + + P C
Sbjct: 397 CPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDP-CPG 455
Query: 3597 REYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIH 3656
++ C + CI L+C+G DC D SDE++C + QF CKNK C P+ W+CD ++
Sbjct: 456 -QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH-QFTCKNK-FCKPLFWVCDSVN 512
Query: 3657 DCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCP 3716
DC D SDE+ C C A F C+N C C+G+DDCGD SDEA V +
Sbjct: 513 DCGDNSDEQGCS-----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 3717 STRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
+ +RC N + C+G ++C D SDE C
Sbjct: 568 TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 124 bits (311), Expect = 2e-27
Identities = 71/176 (40%), Positives = 85/176 (48%), Gaps = 18/176 (10%)
Query: 3636 QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRAD-EFLCNNSLCKLHFWVCD 3694
QF C+ CI CDG DC D SDE NC C A +F C N CK FWVCD
Sbjct: 456 QFTCRT-GRCIRKELRCDGWADCTDHSDELNCS-----CDAGHQFTCKNKFCKPLFWVCD 509
Query: 3695 GEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGK 3754
+DCGDNSDE C + RC N + CL Q CNG D+CGD SDE C
Sbjct: 510 SVNDCGDNSDEQGCSC------PAQTFRCSNGK-CLSKSQQCNGKDDCGDGSDEASCP-- 560
Query: 3755 LTYKARPCKKDEFACSNKKCIPM-DLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 3809
C K + C N C+ + +CD +DC DGSDE+ C +T + V
Sbjct: 561 -KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARV 615
Score = 118 bits (295), Expect = 2e-25
Identities = 68/168 (40%), Positives = 87/168 (51%), Gaps = 20/168 (11%)
Query: 972 QFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC-FDNQFRCSSGRCIPGHWACDGDND 1030
QF C++GRCI + CD DC D SDE+ C SC +QF C + C P W CD ND
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNC--SCDAGHQFTCKNKFCKPLFWVCDSVND 513
Query: 1031 CGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNG 1090
CGD SDE +C + F+C +G C+ +C+G+ DC DGSDE C
Sbjct: 514 CGDNSDEQGCSCPAQT-----------FRCS-NGKCLSKSQQCNGKDDCGDGSDEASCPK 561
Query: 1091 TIRLCDHKTKFSCWSTGRCINKAWV-CDGDIDCEDQSDEDDCDSFLCG 1137
+ K + C + G C++K CDG DC D SDE DCD CG
Sbjct: 562 VNVVTCTKHTYRCLN-GLCLSKGNPECDGKEDCSDGSDEKDCD---CG 605
Score = 115 bits (287), Expect = 1e-24
Identities = 62/156 (39%), Positives = 77/156 (49%), Gaps = 14/156 (8%)
Query: 2724 QFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDG 2783
QF C +CI K CDG DC D DE + C A F+C+ ++ C P W+CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA----GHQFTCK-NKFCKPLFWVCDS 510
Query: 2784 ERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDES--PQCG 2841
DC D SDE GC+ C F C N C+ K C+ DDCGDGSDE+ P+
Sbjct: 511 VNDCGDNSDE---QGCS----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563
Query: 2842 YRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 2877
C + C +G CL +CDG DC D SDE
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 114 bits (286), Expect = 2e-24
Identities = 65/187 (34%), Positives = 87/187 (46%), Gaps = 23/187 (12%)
Query: 2576 DCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYK 2635
D G ++ L S +F C G CI + RC+ DC D SDE NC + D H +
Sbjct: 437 DTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNC-SCDAGHQFT 495
Query: 2636 LGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCI 2695
C W+CD NDCGD SDE C C F C +G+C+
Sbjct: 496 C-----------KNKFCKPLFWVCDSVNDCGDNSDEQGC------SCPAQTFRCSNGKCL 538
Query: 2696 LNTWICDGQKDCEDGRDEFHCDS----SCSWNQFACSAQKCISK-HWICDGEDDCGDGLD 2750
+ C+G+ DC DG DE C +C+ + + C C+SK + CDG++DC DG D
Sbjct: 539 SKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSD 598
Query: 2751 ESDSICG 2757
E D CG
Sbjct: 599 EKDCDCG 605
Score = 113 bits (282), Expect = 5e-24
Identities = 69/173 (39%), Positives = 83/173 (47%), Gaps = 23/173 (13%)
Query: 2507 NSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFK-PCYNRRCI 2565
+SS +F C G CI +L CDG C D SDE N SC G + C N+ C
Sbjct: 448 DSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDEL-----NCSCDAGHQFTCKNKFCK 502
Query: 2566 PHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
P +CD NDCGDNSDE C +C FRC++G C+ +S +CN DC D SDE +C
Sbjct: 503 PLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Query: 2626 ---NNTDCT-HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
N CT H Y RC + CDG DC D SDE C
Sbjct: 560 PKVNVVTCTKHTY----------RCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 110 bits (276), Expect = 2e-23
Identities = 59/146 (40%), Positives = 72/146 (49%), Gaps = 8/146 (5%)
Query: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCE 2708
T C+ CDG DC D+SDEL C H+ F+C + C W+CD DC
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQ-----FTCKNKFCKPLFWVCDSVNDCG 515
Query: 2709 DGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE-SDSICGAITCAADMFS 2767
D DE C SC F CS KC+SK C+G+DDCGDG DE S +TC +
Sbjct: 516 DNSDEQGC--SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYR 573
Query: 2768 CQGSRACVPRHWLCDGERDCPDGSDE 2793
C + CDG+ DC DGSDE
Sbjct: 574 CLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 108 bits (270), Expect = 1e-22
Identities = 80/213 (37%), Positives = 105/213 (49%), Gaps = 33/213 (15%)
Query: 967 CEPLTQFVCKSG-RCISSKWHCD-SDDDCGDGSDEVGCVHS--CFDNQFRCSSGRCIPGH 1022
C +QFV S I+ ++H D S D G ++ + S C QF C +GRCI
Sbjct: 410 CGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPC-PGQFTCRTGRCIRKE 468
Query: 1023 WACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDG 1082
CDG DC D SDE +C G++F C + C P W CD DC D
Sbjct: 469 LRCDGWADCTDHSDELNCSCDA----------GHQFTCK-NKFCKPLFWVCDSVNDCGDN 517
Query: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC---DSFLCGPP 1139
SDE+GC+ C +T F C S G+C++K+ C+G DC D SDE C + C
Sbjct: 518 SDEQGCS-----CPAQT-FRC-SNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKH 570
Query: 1140 KHPCANDTSVCL---QPEKLCNGKKDCPDGSDE 1169
+ C N +CL PE C+GK+DC DGSDE
Sbjct: 571 TYRCLN--GLCLSKGNPE--CDGKEDCSDGSDE 599
Score = 106 bits (265), Expect = 5e-22
Identities = 82/252 (32%), Positives = 107/252 (42%), Gaps = 36/252 (14%)
Query: 2542 EKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADG 2601
E L Y + C F C RCI CDG DC D+SDEL+C S A +F C +
Sbjct: 443 EYLSYDSSDPCPGQFT-CRTGRCIRKELRCDGWADCTDHSDELNC--SCDAGHQFTCKNK 499
Query: 2602 TCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDG 2661
C P C+ DC D SDE+ C+ T RC S C+ + C+G
Sbjct: 500 FCKPLFWVCDSVNDCGDNSDEQGCSCPAQT------------FRC-SNGKCLSKSQQCNG 546
Query: 2662 SNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCI-LNTWICDGQKDCEDGRDEFHCDSSC 2720
+DCGD SDE CP N C ++ + C +G C+ CDG++DC DG DE CD C
Sbjct: 547 KDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD--C 604
Query: 2721 SWNQFACSAQKC-------------ISKHWICDGEDDCGDGLDESDSICGAITCAADMFS 2767
F A+ +S H + G CG L + + A C D
Sbjct: 605 GLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGH-ICGASLISPNWLVSAAHCYID--- 660
Query: 2768 CQGSRACVPRHW 2779
+G R P W
Sbjct: 661 DRGFRYSDPTQW 672
Score = 99.4 bits (246), Expect = 7e-20
Identities = 72/226 (31%), Positives = 103/226 (45%), Gaps = 22/226 (9%)
Query: 3215 PGVIALTLFEDYIYWTDGK-TKSLSRAHKTSGADRLSL-IYSWHAITD---IQVYHSYRQ 3269
PGV A T +DY+ K S+ TS ++++++ +S + TD + Y SY
Sbjct: 390 PGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDS 449
Query: 3270 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTAS-QFRCKTDK 3328
D G C L G C + +D C +C A QF CK
Sbjct: 450 SDPCPGQFTCRTGRCIRKELRCDGWAD---CTDH----SDELNC--SCDAGHQFTCKNKF 500
Query: 3329 CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDE 3388
C P +W CD+V+DCGD SDE C C F+C G C + C+G++DCGD SDE
Sbjct: 501 CKPLFWVCDSVNDCGDNSDE-QGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDE 556
Query: 3389 LNC---DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
+C + C ++C N C+G++DC D DE+DC
Sbjct: 557 ASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 93.2 bits (230), Expect = 5e-18
Identities = 54/152 (35%), Positives = 73/152 (48%), Gaps = 12/152 (7%)
Query: 813 PGGRVCA---CADNQLLDENGTTCTFNPGEALPHICKAG-EFRCKNRHCIQARWKCDGDD 868
PG C C +L + CT + E L C AG +F CKN+ C W CD +
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDE-LNCSCDAGHQFTCKNKFCKPLFWVCDSVN 512
Query: 869 DCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESN-QTCTARTC 927
DC D SDE SCP F+C N +C+ K C+G +DCG DE++ TC
Sbjct: 513 DCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 928 QVDQFSCGNGRCIPRA-WLCDREDDCGDQTDE 958
+ C NG C+ + CD ++DC D +DE
Sbjct: 568 TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 88.6 bits (218), Expect = 1e-16
Identities = 54/171 (31%), Positives = 72/171 (42%), Gaps = 33/171 (19%)
Query: 3678 EFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCN 3737
+F C C CDG DC D+SDE + C + C+N + C +C+
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDE-----LNCSCDAGHQFTCKN-KFCKPLFWVCD 509
Query: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR 3797
+++CGDNSDE C C F CSN KC+ QC+ DDCGDGSDE C
Sbjct: 510 SVNDCGDNSDEQGCS---------CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP 560
Query: 3798 IAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNEC 3848
+ NV C Y RC G + N +C+ +C
Sbjct: 561 --------KVNVVTCTKHTY----------RCLNGLCLSKGNPECDGKEDC 593
Score = 82.4 bits (202), Expect = 9e-15
Identities = 57/164 (34%), Positives = 70/164 (42%), Gaps = 36/164 (21%)
Query: 2810 FMCHNKVCIPKQFVCDHDDDCGDGSDE---SPQCGYRQCGTEEFSCADGRCLLNTQWQCD 2866
F C CI K+ CD DC D SDE S G+ +F+C + C W CD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH------QFTCKNKFCK-PLFWVCD 509
Query: 2867 GDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC- 2925
DC D+SDE SC + F C NG+C+ C+ KDDCGDGSDE +C
Sbjct: 510 SVNDCGDNSDEQGC---------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP 560
Query: 2926 HINE--------------CLSKKVSGC--SQDCQDLPVSYKCKC 2953
+N CLSK C +DC D C C
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 66.2 bits (160), Expect = 7e-10
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 16/109 (14%)
Query: 820 CADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSV 879
C DN DE G +C A FRC N C+ +C+G DDC DGSDE S
Sbjct: 514 CGDNS--DEQGCSCP------------AQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Query: 880 NCFN-HSCPDDQFKCQNNRCIPK-RWLCDGANDCGSNEDESNQTCTART 926
N +C ++C N C+ K CDG DC DE + C R+
Sbjct: 560 PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608
Score = 60.5 bits (145), Expect = 4e-08
Identities = 58/217 (26%), Positives = 75/217 (34%), Gaps = 72/217 (33%)
Query: 1062 PDGNCVPDLWRCDGEKDCEDGS----------------DEKGCNGTIRLCDHKT------ 1099
P G C D +GEK C + S ++ T L ++ +
Sbjct: 393 PAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDP 452
Query: 1100 ---KFSCWSTGRCINKAWVCDGDIDCEDQSDE---------------------------- 1128
+F+C TGRCI K CDG DC D SDE
Sbjct: 453 CPGQFTC-RTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 1129 ----DDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDEC-SLNNGGC 1183
D+ D C P CL + CNGK DC DGSDE C +N C
Sbjct: 512 NDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEA----SCPKVNVVTC 567
Query: 1184 SNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSN 1220
+ H C GL L+K N C+ + CS+
Sbjct: 568 TKH---------TYRCLNGLCLSKGNPECDGKEDCSD 595
Score = 59.7 bits (143), Expect = 7e-08
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 24/130 (18%)
Query: 32 CDPG-EFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
CD G +F C + C W+CD DC D+SDE +CP + +C KC
Sbjct: 488 CDAGHQFTCKNKF-CKPLFWVCDSVNDCGDNSDEQGCSCPAQT-FRC--------SNGKC 537
Query: 91 VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDG 150
+ SQ CNG DC DG DE ++C ++N T +++ RC +G +++
Sbjct: 538 LSKSQQCNGKDDCGDGSDE--------ASCPKVNV---VTCTKHTYRCL--NGLCLSKGN 584
Query: 151 RSCKDQDECA 160
C +++C+
Sbjct: 585 PECDGKEDCS 594
Score = 49.7 bits (117), Expect = 7e-05
Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 32/150 (21%)
Query: 3761 PCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRI-APTEYTCE-----------DN 3808
PC +F C +CI +L+CD DC D SDE C A ++TC+ D+
Sbjct: 452 PCP-GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDS 510
Query: 3809 VNPCGDDAYCNQIKTSVFC-----RCKPGFQRNMKNRQCEDLNECLVFGTCSHQC--INV 3861
VN CGD N + C RC G + K++QC ++C G+ C +NV
Sbjct: 511 VNDCGD----NSDEQGCSCPAQTFRCSNG-KCLSKSQQCNGKDDC-GDGSDEASCPKVNV 564
Query: 3862 ----EGSYKCVCDQNFQERNNTCIAEGSED 3887
+ +Y+C+ + N C +G ED
Sbjct: 565 VTCTKHTYRCLNGLCLSKGNPEC--DGKED 592
Score = 48.5 bits (114), Expect = 2e-04
Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 24 GADRDQQLCD-PGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHI 82
G + D+Q C P + + C+S+S C+G DC D SDE+ +CP+ + C +
Sbjct: 515 GDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEA--SCPKVNVVTCTKHTY 572
Query: 83 ACLGTNKCVHLSQLCNGVLDCPDGYDE 109
CL + C+G DC DG DE
Sbjct: 573 RCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 37.0 bits (84), Expect = 0.45
Identities = 24/89 (26%), Positives = 32/89 (35%), Gaps = 23/89 (25%)
Query: 2489 CSCRGDRILLEDNRCVTKNSSCNAYSE----------------------FECGNGECIDY 2526
CSC + +C++K+ CN + + C NG C+
Sbjct: 523 CSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSK 582
Query: 2527 -QLTCDGIPHCKDKSDEKLLYCENRSCRR 2554
CDG C D SDEK C RS R
Sbjct: 583 GNPECDGKEDCSDGSDEKDCDCGLRSFTR 611
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 148 bits (374), Expect = 1e-34
Identities = 84/211 (39%), Positives = 118/211 (55%), Gaps = 8/211 (3%)
Query: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
+ +D+ + ++YWTDV I R L E G E +V GL +PEGL +D I +Y
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGL-ELGAEP--ETIVNSGLISPEGLAIDHIRRTMY 1201
Query: 1351 WIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
W DS LD+IE A LDGS R L + +PRAIA+DP G L+WTDW+ P+IE++S+
Sbjct: 1202 WTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD 1261
Query: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLS 1470
G R+ + PNGLT D F K + W DA + + L DGT +I+ + L
Sbjct: 1262 GENRRILIN--TDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNN--LK 1316
Query: 1471 HPFAVSLYGSEVYWTDWRTNTLSKANKWTGQ 1501
+PF++ Y Y TDWR + + NK +GQ
Sbjct: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
Score = 125 bits (313), Expect = 1e-27
Identities = 80/230 (34%), Positives = 122/230 (53%), Gaps = 9/230 (3%)
Query: 1877 IESFLMYSVHEGIRGIPLEPS----DKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFN 1932
+ +FL+Y+ + I +PL + D L+ + G S VGID+ +YWTD+
Sbjct: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTDVAGR 1164
Query: 1933 KISRAKRDQTWK-EDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVII 1991
ISRA + + E I+ +GL EG+A+D I +YWTD + IE A L+GS R V+
Sbjct: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLF 1224
Query: 1992 SQGLDQPRSIAVHPEKGLLFWTEWG-QMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYE 2050
L PR+IAV P +G L+WT+W + P I + LDG + +L++ I PNG++ D
Sbjct: 1225 YTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPF 1284
Query: 2051 ENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD 2100
L W DA T K+E L G R ++ + FS+ + + Y +D
Sbjct: 1285 SKLLCWADAGTKKLE-CTLPDGTGRRVIQNNLKYP-FSIVSYADHFYHTD 1332
Score = 116 bits (291), Expect = 5e-25
Identities = 70/232 (30%), Positives = 117/232 (50%), Gaps = 13/232 (5%)
Query: 561 LDFHAETNYIYFADTTSFLIGRQKID-GTERETILKDDLDNVEGIAVDWIGNNLYWTNDG 619
+D+ +Y+ D I R ++ G E ETI+ L + EG+A+D I +YWT D
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT-DS 1205
Query: 620 HRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKA 679
I A L+ RK L ++ +PR I VDP+ G +YWTDW + +IE +
Sbjct: 1206 VLDKIESALLD--GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE-----APKIETS 1258
Query: 680 WMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739
+DG NR+I + + + PNGLT D + L W DA +E +GT R+++ + L
Sbjct: 1259 SLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN--NLK 1316
Query: 740 HPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVT--LLRHERPPLFGLQIYDP 789
+PF + + ++ + TD+ + ++ + + T L +R L+G+ P
Sbjct: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYP 1368
Score = 108 bits (269), Expect = 2e-22
Identities = 157/643 (24%), Positives = 251/643 (39%), Gaps = 94/643 (14%)
Query: 2668 YSDE---LKCPVQNK-HKCEENYFSCPSGRCILNTWICDGQKDCEDGRD-EFHCDSSCSW 2722
Y+DE L+ V N+ +E+ P C + +CD C G ++ C+ + +
Sbjct: 733 YNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY 792
Query: 2723 NQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHW--- 2779
+ C+ ++ G CG +S+C + + G RH
Sbjct: 793 QG---DGRNCVDENECATGFHRCGP-----NSVCINLPGSYRCECRSGYEFADDRHTCIL 844
Query: 2780 LCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQ----FVCDHDDDCGDGSD 2835
+ C DGS + AG A + F C C+P C D+C +
Sbjct: 845 ITPPANPCEDGSHTCAPAGQARCVHHGGSTFSC---ACLPGYAGDGHQCTDVDECSENRC 901
Query: 2836 ESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC-PDHSDEAPLNPKCKSAEQSCNSS 2894
Y G+ FSC RC + DG F C PD + L P C+ ++ +
Sbjct: 902 HPAATCYNTPGS--FSC---RC--QPGYYGDG-FQCIPDSTSS--LTP-CEQQQRHAQAQ 950
Query: 2895 FF---------MC-KNGRCIP-----SGGLCDNKDDCGDGSDERNCHINECLSKKVSGCS 2939
+ C + G +P S G C D DG + + G S
Sbjct: 951 YAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDP--DGHEVPGTQTPPGSTPPHCGPS 1008
Query: 2940 QDCQDLPVSYKCKCWPGFQLKDDGKTCVD---IDECSS-GFPCSQQCINTYGTYKCLCTD 2995
+ P + C+ W L+ G T D + +C G QC C+ D
Sbjct: 1009 PEPTQRPPTI-CERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKD 1067
Query: 2996 GYEIQ-----PDNPNGC-----------KSLSDEEP-----FLILADHHEIRKISTDGSN 3034
G E+Q P C D P FL+ +I + +G+
Sbjct: 1068 GREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTR 1127
Query: 3035 Y------TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLN-GSDIKVVHNTA 3087
TLL + ++ ID+D RE +YW D + G I+R L G++ + + N+
Sbjct: 1128 LQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA---GRTISRAGLELGAEPETIVNSG 1184
Query: 3088 V--PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLY 3145
+ P LA+D I + +YW+D+ IE + L+G +L L PR +++DP G LY
Sbjct: 1185 LISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLY 1244
Query: 3146 WIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMD 3202
W D E P I +DG N+ ++I T I P LT D ++ L WAD +E + D
Sbjct: 1245 WTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPD 1304
Query: 3203 GSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSG 3245
G+ R + N ++ ++ + D+ Y TD + + +K SG
Sbjct: 1305 GTGRRVIQN-NLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 99.8 bits (247), Expect = 6e-20
Identities = 66/207 (31%), Positives = 103/207 (49%), Gaps = 11/207 (5%)
Query: 1575 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTV--IDFDASEERLYWTDIKTQTIKR 1632
FLLY + +I + ++ A T+ + + ID+D E +YWTD+ +TI R
Sbjct: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
Query: 1633 AFIN-GTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIH- 1690
A + G ET+++ + S GLA+D + R +YW S D +I A LDGS + + +
Sbjct: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLD--KIESALLDGSERKVLFYT 1226
Query: 1691 GIDKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKILFQNQ-KEPVGLSIDYVEN 1745
+ P+ +A P+RG LYWTD N I +++DG N +IL P GL+ D
Sbjct: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK 1286
Query: 1746 KLYWISSGNGTINRCNLDGGNLEVIES 1772
L W +G + DG VI++
Sbjct: 1287 LLCWADAGTKKLECTLPDGTGRRVIQN 1313
Score = 98.2 bits (243), Expect = 2e-19
Identities = 85/301 (28%), Positives = 138/301 (45%), Gaps = 26/301 (8%)
Query: 153 CKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFE 212
C D+D V GT SQ T +C+ + + + P LL +
Sbjct: 1063 CVDKDGREVQGTRSQP------GTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQ 1116
Query: 213 TIEVFYLNGSKMA-----TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKA 267
I LNG+++ TL S++G+ I +D+ E M+ W + + I++A
Sbjct: 1117 QIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRT-------ISRA 1169
Query: 268 G---GLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE 324
G G E +N + + +AID + R +Y+ D V D+I +GS L +
Sbjct: 1170 GLELGAEPETIVN--SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTD 1227
Query: 325 LHNPKAIAVDPIAGKLFFTDYGNVA-KVERCDMDGMNRTRIIDSKTEQPAALALDLVNKL 383
L NP+AIAVDPI G L++TD+ A K+E +DG NR +I++ P L D +KL
Sbjct: 1228 LVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKL 1287
Query: 384 VYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFN 443
+ W D + G R VIQ +++ + I + D+ Y T+ +V +N+ +
Sbjct: 1288 LCWADAGTKKLECTLPDGTGRR-VIQ-NNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHS 1345
Query: 444 G 444
G
Sbjct: 1346 G 1346
Score = 95.9 bits (237), Expect = 8e-19
Identities = 59/198 (29%), Positives = 100/198 (50%), Gaps = 7/198 (3%)
Query: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
E ++ + S EGLA T+YWT S I +D + V+ ++
Sbjct: 1176 EPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSE------RKVLFYTDLV 1229
Query: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
+P +A+D + ++WT+WN + P I S+L G+N +++++TDI PNGLT D ++ L
Sbjct: 1230 NPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLC 1289
Query: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGD 2438
++D K+E DG+ R VI + F S+ Y ++ + +DW R ++ NK++G
Sbjct: 1290 WADAGTKKLECTLPDGTGRRVIQNNLKYPF-SIVSYADHFYHTDWRRDGVVSVNKHSGQF 1348
Query: 2439 TKILRSDIPHQPMGIIAV 2456
T + GI AV
Sbjct: 1349 TDEYLPEQRSHLYGITAV 1366
Score = 79.3 bits (194), Expect = 8e-14
Identities = 73/256 (28%), Positives = 109/256 (42%), Gaps = 33/256 (12%)
Query: 3919 HNSRITGMDVYYQRDMIIWST----QFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDI 3974
H S I G+D + M+ W+ + G+ + + NSGLI PE +
Sbjct: 1140 HGSIIVGIDYDCRERMVYWTDVAGRTISRAGL---ELGAEPETIVNSGLISPE-----GL 1191
Query: 3975 AVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAV 4034
A+D + +YWTD S+ I L+G L P AIAV
Sbjct: 1192 AIDHIRRTMYWTD---------------SVLDKIESALLDGSERKVLFYTDLVNPRAIAV 1236
Query: 4035 NPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELS 4093
+P RG +YWT + IE +++DG RRIL+ ++ P GL D FS+ + WAD
Sbjct: 1237 DPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTK 1296
Query: 4094 IIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKF-GHGSVEYL 4151
+ L DG+ V + L +P I + D+ Y ++GV V K G + EYL
Sbjct: 1297 KLECTLPDGTGRRV---IQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYL 1353
Query: 4152 ALNIDKTKGVLISHRY 4167
G+ + Y
Sbjct: 1354 PEQRSHLYGITAVYPY 1369
Score = 68.2 bits (165), Expect = 2e-10
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 17/183 (9%)
Query: 1273 IDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEH 1332
++L +++ GL + L + +YWTD V D+I L S +V+
Sbjct: 1171 LELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDG----SERKVLFYT 1226
Query: 1333 GLATPEGLTVDWIAGNIYWIDSNLD--QIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYG 1390
L P + VD I GN+YW D N + +IE + LDG R LI + P + DP
Sbjct: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK 1286
Query: 1391 ILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLT--VDHFEKRIVWTDARSDA 1448
+L W DA ++E G GR+ I ++K +P + DHF TD R D
Sbjct: 1287 LLCWA--DAGTKKLECTLPDGTGRRVIQNNLK---YPFSIVSYADHF----YHTDWRRDG 1337
Query: 1449 IYS 1451
+ S
Sbjct: 1338 VVS 1340
Score = 65.9 bits (159), Expect = 9e-10
Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 11/192 (5%)
Query: 1635 INGTGLETVISRDIQSIRGLAV-----DWVSRNLYWISSEFDETQINVARLDGSLKTSII 1689
+NGT L+ ++ + S+ G + D R +YW L +T +
Sbjct: 1123 LNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVN 1182
Query: 1690 HGIDKPQCLAAHPVRGKLYWTDG--NTINMANMDGSNSKILFQNQK-EPVGLSIDYVENK 1746
G+ P+ LA +R +YWTD + I A +DGS K+LF P +++D +
Sbjct: 1183 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN 1242
Query: 1747 LYWISSGNGT--INRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCS 1804
LYW I +LDG N ++ + L K L WAD +L C+
Sbjct: 1243 LYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKL-ECT 1301
Query: 1805 KRDGRNPTILRN 1816
DG +++N
Sbjct: 1302 LPDGTGRRVIQN 1313
Score = 61.6 bits (148), Expect = 2e-08
Identities = 47/201 (23%), Positives = 88/201 (43%), Gaps = 11/201 (5%)
Query: 545 ADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGI 604
A+ I L++P L +Y+ D+ I +DG+ER+ + DL N I
Sbjct: 1175 AEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAI 1234
Query: 605 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDW 664
AVD I NLYWT D +R+ + ++R+ L+ ++ P G+ DP + + W
Sbjct: 1235 AVDPIRGNLYWT-DWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWA-- 1291
Query: 665 EEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFL 724
D ++E DG R++ + + + +P ++ + + Y D D + V
Sbjct: 1292 -----DAGTKKLECTLPDGTGRRV-IQNNLKYP--FSIVSYADHFYHTDWRRDGVVSVNK 1343
Query: 725 NGTHRKIVYSGRELNHPFGLS 745
+ Y + +H +G++
Sbjct: 1344 HSGQFTDEYLPEQRSHLYGIT 1364
Score = 59.3 bits (142), Expect = 9e-08
Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 6/151 (3%)
Query: 1614 DASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDET 1673
D +YWTD I+ A ++G+ + + D+ + R +AVD + NLYW +
Sbjct: 1194 DHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
Query: 1674 QINVARLDGSLKTSIIH-GIDKPQCLAAHPVRGKLYWTDGNT--INMANMDGSNSKILFQ 1730
+I + LDG + +I+ I P L P L W D T + DG+ +++
Sbjct: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN 1313
Query: 1731 NQKEPVGLSIDYVENKLY--WISSGNGTINR 1759
N K P + + Y ++ + W G ++N+
Sbjct: 1314 NLKYPFSI-VSYADHFYHTDWRRDGVVSVNK 1343
Score = 56.2 bits (134), Expect = 7e-07
Identities = 45/138 (32%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 624 INVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGR-IEKAWMD 682
+N RL+K + KTLL S GI D +YWTD GR I +A ++
Sbjct: 1123 LNGTRLQK--DAAKTLLSLHGSIIVGIDYDCRERMVYWTD--------VAGRTISRAGLE 1172
Query: 683 -GFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHP 741
G + V S ++ P GL +D T+YW D+ D IE L+G+ RK+++ +L +P
Sbjct: 1173 LGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFY-TDLVNP 1231
Query: 742 FGLS---HHGNYVFWTDY 756
++ GN ++WTD+
Sbjct: 1232 RAIAVDPIRGN-LYWTDW 1248
Score = 52.8 bits (125), Expect = 8e-06
Identities = 33/118 (27%), Positives = 65/118 (55%), Gaps = 6/118 (5%)
Query: 2329 QNLMFWTNWNEQHPSIMRSTLT-GKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKI 2387
+ +++WT+ + +I R+ L G + +V++ +++P GL ID+ +Y++D L KI
Sbjct: 1153 ERMVYWTDVAGR--TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKI 1210
Query: 2388 ERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSDWGRRA-ILRSNKYTGGDTKIL 2442
E DGS+R V+ + ++AV ++W+DW R A + ++ G + +IL
Sbjct: 1211 ESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRIL 1268
Score = 49.3 bits (116), Expect = 9e-05
Identities = 47/198 (23%), Positives = 67/198 (33%), Gaps = 34/198 (17%)
Query: 3694 DGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGG 3753
DG C + P V + C ++ + R C+ + G CG NS
Sbjct: 765 DGSHMCDTTARCHPGTGVDYTCECASGYQ-GDGRNCVDENECATGFHRCGPNS------- 816
Query: 3754 KLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC-RIAPTEYTCEDNVNPC 3812
C N +P +C+ D C I P CED + C
Sbjct: 817 --------------VCIN---LPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTC 859
Query: 3813 GD--DAYCNQIKTSVF-CRCKPGFQRNMKNRQCEDLNECLVFGTC--SHQCINVEGSYKC 3867
A C S F C C PG+ + QC D++EC C + C N GS+ C
Sbjct: 860 APAGQARCVHHGGSTFSCACLPGYAGD--GHQCTDVDECSE-NRCHPAATCYNTPGSFSC 916
Query: 3868 VCDQNFQERNNTCIAEGS 3885
C + CI + +
Sbjct: 917 RCQPGYYGDGFQCIPDST 934
Score = 47.8 bits (112), Expect = 3e-04
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 138 CYCEDGFEITEDGRSCKDQDECAV-YGTC--SQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
C C G++ DGR+C D++ECA + C + C N GSY C C GY D +C
Sbjct: 786 CECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
Score = 45.8 bits (107), Expect = 0.001
Identities = 29/83 (34%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 3805 CEDNVNPCGDDAYCNQ-IKTSVFCRCKPGFQRNMKNRQCEDLNECLV-FGTCSHQ--CIN 3860
C D + C A C+ C C G+Q + +N C D NEC F C CIN
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN--CVDENECATGFHRCGPNSVCIN 820
Query: 3861 VEGSYKCVC--DQNFQERNNTCI 3881
+ GSY+C C F + +TCI
Sbjct: 821 LPGSYRCECRSGYEFADDRHTCI 843
Score = 44.3 bits (103), Expect = 0.003
Identities = 46/171 (26%), Positives = 65/171 (38%), Gaps = 29/171 (16%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C G +C C + + D +C C +E E C C + C+
Sbjct: 763 CYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENE--CATGFHRCGPNSVCI 819
Query: 92 HL--SQLCNGVLDCPDGYD--EGVH-----------CQELLSNCQQLNCQYKCTMVRNST 136
+L S C +C GY+ + H C++ C Q +C ST
Sbjct: 820 NLPGSYRC----ECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG-QARCVHHGGST 874
Query: 137 -RCYCEDGFEITEDGRSCKDQDECAVYGTC--SQTCRNTHGSYTCSCVEGY 184
C C G+ DG C D DEC+ C + TC NT GS++C C GY
Sbjct: 875 FSCACLPGY--AGDGHQCTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
Score = 40.8 bits (94), Expect = 0.031
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 21/184 (11%)
Query: 4184 LCLLNPSGATCVCPEGKYLING--TCNDDSLLDDSCK---LTCENGG--RCILNEKGDLR 4236
+C+ P C C G + TC + + C+ TC G RC+ +
Sbjct: 817 VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFS 876
Query: 4237 CHCWPSYSGE--RC-EVNHCS-NYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
C C P Y+G+ +C +V+ CS N C TC + G +C C G+ G
Sbjct: 877 CACLPGYAGDGHQCTDVDECSENRCHPAATCY-NTPGSFSCRCQPGYYGDGFQ------- 928
Query: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CHHYCVNSESCTIGDDGSVECVCPTR 4350
C T +T Q H Q +Y ++++ C G G CV P
Sbjct: 929 CIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDG 988
Query: 4351 YEGP 4354
+E P
Sbjct: 989 HEVP 992
Score = 40.4 bits (93), Expect = 0.041
Identities = 40/163 (24%), Positives = 55/163 (33%), Gaps = 38/163 (23%)
Query: 4221 CENGGRCILNEKGDLRCHCWPSYSGE--RC-EVNHCS---NYCQNGGTCVPSVLGRPTCS 4274
C+ RC D C C Y G+ C + N C+ + C C+ ++ G C
Sbjct: 770 CDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCI-NLPGSYRCE 828
Query: 4275 CALGFTGPNCGKTV---------CED---FCQNGG--TCIVTAGNQPYCHCQPEYTGDRC 4320
C G+ + T CED C G C+ G+ C C P Y GD
Sbjct: 829 CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGD-- 886
Query: 4321 QYYVCHHYCVNSESCT----------IGDDGSVECVCPTRYEG 4353
H C + + C+ GS C C Y G
Sbjct: 887 -----GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYG 924
Score = 38.9 bits (89), Expect = 0.12
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 41/223 (18%)
Query: 3425 EEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADA--SDEANC-DKKTCGPHEF 3481
+ED P N C C TT C V D +CA D NC D+ C
Sbjct: 752 KEDSDPTPGNPCYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENECATGFH 810
Query: 3482 QC-KNNNCI--PDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDF 3538
+C N+ CI P +RC+ ++ D C T C DG
Sbjct: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP--CE-----------DGSH 857
Query: 3539 DCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGE-DEKSCEPASPTCSSR 3597
CA R S F C+ C+P + DGH+ E E C PA+ TC +
Sbjct: 858 TCAPAGQARCVHHGGS--TFSCA---CLPG-YAGDGHQCTDVDECSENRCHPAA-TCYNT 910
Query: 3598 EYICASDGCISASLKCNGEYDCADG----SDEMDCVTECKEDQ 3636
S S +C Y DG D +T C++ Q
Sbjct: 911 PG--------SFSCRCQPGY-YGDGFQCIPDSTSSLTPCEQQQ 944
Score = 38.9 bits (89), Expect = 0.12
Identities = 49/193 (25%), Positives = 67/193 (34%), Gaps = 50/193 (25%)
Query: 4254 SNYCQNGGTCVPSVLGRPTCSCALGFTGP--NCGKTVCEDFCQNG-------GTCIVTAG 4304
S+ C C P TC CA G+ G NC V E+ C G CI G
Sbjct: 767 SHMCDTTARCHPGTGVDYTCECASGYQGDGRNC---VDENECATGFHRCGPNSVCINLPG 823
Query: 4305 NQPYCHCQP--EYTGDRCQYYVC-------------HHYC--VNSESCTIGDDGSVECVC 4347
+ C C+ E+ DR + C H C C + C C
Sbjct: 824 SY-RCECRSGYEFADDR---HTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 879
Query: 4348 PTRY--EGPKC-EVDKCV--RCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGG 4402
Y +G +C +VD+C RCH C N + SC+ GY +G
Sbjct: 880 LPGYAGDGHQCTDVDECSENRCHPA------------ATCYNTPGSFSCRCQPGYYGDGF 927
Query: 4403 TCQLDPETNVPVC 4415
C D +++ C
Sbjct: 928 QCIPDSTSSLTPC 940
Score = 38.9 bits (89), Expect = 0.12
Identities = 36/123 (29%), Positives = 47/123 (38%), Gaps = 27/123 (21%)
Query: 793 QGDNMCRVNNGGCST---------LCLAIPGGRVCACADNQLLDENGTTCTF-----NPG 838
QGD V+ C+T +C+ +PG C C ++ TC NP
Sbjct: 793 QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPC 852
Query: 839 EALPHIC-KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNR 897
E H C AG+ RC H + + C CL G D H C D +C NR
Sbjct: 853 EDGSHTCAPAGQARCV--HHGGSTFSC----ACLPGYAGD-----GHQCTDVD-ECSENR 900
Query: 898 CIP 900
C P
Sbjct: 901 CHP 903
Score = 35.8 bits (81), Expect = 1.0
Identities = 38/148 (25%), Positives = 55/148 (37%), Gaps = 21/148 (14%)
Query: 1125 QSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDG-SDEGYLC---DECSLNN 1180
+ D D C H C DT+ P + +C G +G C +EC+
Sbjct: 752 KEDSDPTPGNPCYDGSHMC--DTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGF 809
Query: 1181 GGCSNH--CSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK-----CSQV----CE 1229
C + C +PG C C G + D TC ++ +N + C+ C
Sbjct: 810 HRCGPNSVCINLPG-SYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCV 868
Query: 1230 QH-KHTVKCSCYEGWKLDVDGESCTSVD 1256
H T C+C G+ DG CT VD
Sbjct: 869 HHGGSTFSCACLPGYA--GDGHQCTDVD 894
Score = 35.0 bits (79), Expect = 1.7
Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 17/111 (15%)
Query: 3761 PCKKDEFAC-SNKKCIP---MDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDA 3816
PC C + +C P +D C+ C G G R E C + CG ++
Sbjct: 762 PCYDGSHMCDTTARCHPGTGVDYTCE----CASGYQGDG-RNCVDENECATGFHRCGPNS 816
Query: 3817 YCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
C + S C C+ G++ +D + C++ ++ C +GS+ C
Sbjct: 817 VCINLPGSYRCECRSGYE------FADDRHTCILITPPANPC--EDGSHTC 859
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 142 bits (357), Expect = 1e-32
Identities = 78/224 (34%), Positives = 94/224 (41%), Gaps = 53/224 (23%)
Query: 3435 SCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT------------------- 3475
+C+ F C + C++ + CD PDC D SDE NC++
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 3476 ---------------------------CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEE 3508
CGP E C+N +CIP + CD Q DC D SDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 3509 NC-KPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETS-----CSKDQFRC-S 3561
+C P C +F C NG C + CDGDFDC D +DE NC T C QFRC S
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS 377
Query: 3562 NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDG 3605
CIPA + CD DC DE C P RE I AS G
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRG 421
Score = 121 bits (304), Expect = 1e-26
Identities = 73/216 (33%), Positives = 92/216 (42%), Gaps = 14/216 (6%)
Query: 2591 CATVEFRCAD-GTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNST 2649
C EF C C+ RC++ DC D SDE NC LG+ T + +T
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEP------VLGISPTFSLLVETT 252
Query: 2650 SLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCED 2709
SL P L C +C +G CI ++CDGQ+DCED
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCED 312
Query: 2710 GRDEFHC--DSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD--SICGAITCAADM 2765
G DE C C N+F C C K W CDG+ DC D DE++ + C
Sbjct: 313 GSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372
Query: 2766 FSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAP 2801
F C + C+P + CD E DCPD SDE GC P
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEF---GCMP 405
Score = 121 bits (303), Expect = 2e-26
Identities = 77/214 (35%), Positives = 93/214 (43%), Gaps = 55/214 (25%)
Query: 3353 PEF--RCQPGRFQCGT-GLCALPAFICDGENDCGDNSDELNCD----------------- 3392
P+F C F C + C + CD DC D SDELNC+
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 3393 ----------------THV---CLSG---------QFKCTKNQKCIPVNLRCNGQDDCGD 3424
TH L G Q +N CIP + C+GQ+DC D
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCED 312
Query: 3425 EEDERDC-PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKK----TCGPH 3479
DE DC P C P+ F C HC KLW CD D DC D +DEANC K CGP
Sbjct: 313 GSDELDCGPPPPCEPNEFPC-GNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPT 371
Query: 3480 EFQCKNNN-CIPDHWRCDSQNDCSDNSDEENCKP 3512
+F+C + N CIP + CD ++DC D SDE C P
Sbjct: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMP 405
Score = 118 bits (296), Expect = 1e-25
Identities = 67/209 (32%), Positives = 87/209 (41%), Gaps = 54/209 (25%)
Query: 3512 PQTCTLKDFLCAN-GDCVSSRFWCDGDFDCADGSDERNCETS------------------ 3552
P+ CT +F C + +CV+ + CD DC D SDE NCE
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 3553 -----------------------------CSKDQFRCSNGQCIPAKWKCDGHEDCKYGED 3583
C + C NG CIP + CDG EDC+ G D
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 3584 EKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTE-----CKEDQFR 3638
E C P P C E+ C + C +C+G++DC D +DE +C T+ C QFR
Sbjct: 316 ELDCGPPPP-CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFR 374
Query: 3639 CKNKAHCIPIRWLCDGIHDCVDGSDEENC 3667
C + CIP + CD DC D SDE C
Sbjct: 375 CVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 117 bits (292), Expect = 3e-25
Identities = 72/221 (32%), Positives = 100/221 (45%), Gaps = 17/221 (7%)
Query: 842 PHICKAGEFRCKN-RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSC---PDDQFKCQNNR 897
P C EF C + C+ ++CD DC D SDE +NC P +
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDE--LNCEEPVLGISPTFSLLVETTS 253
Query: 898 CIPKRWLCDGANDCGSNEDESNQTCTART--CQVDQFSCGNGRCIPRAWLCDREDDCGDQ 955
P+ ++ + + R C + +C NG CIPR +LCD ++DC D
Sbjct: 254 LPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313
Query: 956 TDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC-----VHSCFDNQ 1010
+DE+ P CEP +F C +G C W CD D DC D +DE C C Q
Sbjct: 314 SDELDCGPPPPCEP-NEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372
Query: 1011 FRC-SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSP 1050
FRC S+ CIP + CD ++DC D SDE C ++ +P
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDE--FGCMPPQVVTP 411
Score = 117 bits (292), Expect = 3e-25
Identities = 66/208 (31%), Positives = 86/208 (41%), Gaps = 52/208 (25%)
Query: 3474 KTCGPHEFQCKN-NNCIPDHWRCDSQNDCSDNSDEENC---------------------- 3510
+ C EF C + N C+ +RCD + DC D SDE NC
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 3511 ------------------------KPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE 3546
+P C ++ C NG C+ + CDG DC DGSDE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 3547 RNC--ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP--TCSSREYICA 3602
+C C ++F C NG C W+CDG DC+ DE +C P C ++ C
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 3603 SDG-CISASLKCNGEYDCADGSDEMDCV 3629
S CI AS C+ E DC D SDE C+
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDEFGCM 404
Score = 114 bits (285), Expect = 2e-24
Identities = 68/209 (32%), Positives = 94/209 (44%), Gaps = 5/209 (2%)
Query: 2719 SCSWNQFAC-SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPR 2777
+C+ +FAC S +C++ + CD DC D DE + + + + + PR
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 2778 HWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDES 2837
+ + + G C C N CIP+ ++CD +DC DGSDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 2838 PQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFM 2897
C EF C +G C L W+CDGDFDC D +DEA N K E+ C + F
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCALKL-WRCDGDFDCEDRTDEA--NCPTKRPEEVCGPTQFR 374
Query: 2898 C-KNGRCIPSGGLCDNKDDCGDGSDERNC 2925
C CIP+ CD + DC D SDE C
Sbjct: 375 CVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 112 bits (280), Expect = 8e-24
Identities = 71/215 (33%), Positives = 94/215 (43%), Gaps = 59/215 (27%)
Query: 925 RTCQVDQFSCGN-GRCIPRAWLCDREDDCGDQTDEMASCEFPTC---------------- 967
R C +F+C + C+ + CDR DC D +DE+ +CE P
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDEL-NCEEPVLGISPTFSLLVETTSLP 255
Query: 968 -----------------EPLT------------QFVCKSGRCISSKWHCDSDDDCGDGSD 998
+PL + C++G CI + CD +DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 999 EVGC--VHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINC-TK--EEIHSPAGC 1053
E+ C C N+F C +G C W CDGD DC D +DEA NC TK EE+ C
Sbjct: 316 ELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEA--NCPTKRPEEV-----C 368
Query: 1054 NGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC 1088
+F+C C+P + CD E DC D SDE GC
Sbjct: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 111 bits (278), Expect = 1e-23
Identities = 51/119 (42%), Positives = 63/119 (52%), Gaps = 4/119 (3%)
Query: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC 3376
C + C+ CIP + CD +DC DGSDE D P C+P F CG G CAL + C
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRC 344
Query: 3377 DGENDCGDNSDELNCDT----HVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
DG+ DC D +DE NC T VC QF+C CIP + C+ + DC D DE C
Sbjct: 345 DGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 110 bits (275), Expect = 3e-23
Identities = 73/228 (32%), Positives = 97/228 (42%), Gaps = 64/228 (28%)
Query: 963 EFPTCEPLTQFVCKS-GRCISSKWHCDSDDDCGDGSDEVGC------------------- 1002
+FP +F C S C++ ++ CD DC D SDE+ C
Sbjct: 194 QFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTS 253
Query: 1003 ---------------VHS-------------CFDNQFRCSSGRCIPGHWACDGDNDCGDF 1034
H+ C + C +G CIP + CDG DC D
Sbjct: 254 LPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313
Query: 1035 SDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC--NGTI 1092
SDE ++C P C NEF C +G+C LWRCDG+ DCED +DE C
Sbjct: 314 SDE--LDCGP-----PPPCEPNEFPCG-NGHCALKLWRCDGDFDCEDRTDEANCPTKRPE 365
Query: 1093 RLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
+C T+F C ST CI ++ CD + DC D+SDE F C PP+
Sbjct: 366 EVCG-PTQFRCVSTNMCIPASFHCDEESDCPDRSDE-----FGCMPPQ 407
Score = 107 bits (267), Expect = 3e-22
Identities = 68/210 (32%), Positives = 97/210 (46%), Gaps = 52/210 (24%)
Query: 1005 SCFDNQFRCSS-GRCIPGHWACDGDNDCGDFSDEAQINCTKEEI---------------- 1047
+C + +F C S C+ + CD DC D SDE +NC + +
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDE--LNCEEPVLGISPTFSLLVETTSLP 255
Query: 1048 --------------HSPAG----------CNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
H+P C E C +G+C+P + CDG++DCEDGS
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-NGHCIPRDYLCDGQEDCEDGS 314
Query: 1084 DEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS----FLCGPP 1139
DE C G C+ +F C G C K W CDGD DCED++DE +C + +CGP
Sbjct: 315 DELDC-GPPPPCE-PNEFPC-GNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPT 371
Query: 1140 KHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
+ C + T++C+ C+ + DCPD SDE
Sbjct: 372 QFRCVS-TNMCIPASFHCDEESDCPDRSDE 400
Score = 104 bits (260), Expect = 2e-21
Identities = 70/215 (32%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 3552 SCSKDQFRC-SNGQCIPAKWKCDGHEDCKYGEDEKSC-EPA---SPTCSSREYICASDGC 3606
+C++ +F C S +C+ +++CD DC+ DE +C EP SPT S +
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 3607 ISASLKCNGEYDCADGSDEMDCVTE--CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDE 3664
++ A V C + C+N HCIP +LCDG DC DGSDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN-GHCIPRDYLCDGQEDCEDGSDE 316
Query: 3665 ENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPH--- 3721
+C C +EF C N C L W CDG+ DC D +DEA CP+ RP
Sbjct: 317 LDCGPPPP-CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEAN-------CPTKRPEEVC 368
Query: 3722 -----RCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
RC + +C+ + C+ +C D SDE C
Sbjct: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 102 bits (255), Expect = 7e-21
Identities = 63/206 (30%), Positives = 82/206 (39%), Gaps = 52/206 (25%)
Query: 3317 CTASQFRCKT-DKCIPFWWKCDTVDDCGDGSDE--------------------------- 3348
CT ++F C + ++C+ ++CD DC D SDE
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3349 ------------------PDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELN 3390
P C P C G C ++CDG+ DC D SDEL+
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 3391 C-DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC----PENSCSPDYFQCKT 3445
C C +F C N C RC+G DC D DE +C PE C P F+C +
Sbjct: 319 CGPPPPCEPNEFPC-GNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS 377
Query: 3446 TKHCISKLWVCDEDPDCADASDEANC 3471
T CI + CDE+ DC D SDE C
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 98.2 bits (243), Expect = 2e-19
Identities = 52/128 (40%), Positives = 65/128 (50%), Gaps = 10/128 (7%)
Query: 837 PGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCF-NHSCPDDQFKCQN 895
PG P C E C+N HCI + CDG +DC DGSDE ++C C ++F C N
Sbjct: 277 PGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE--LDCGPPPPCEPNEFPCGN 334
Query: 896 NRCIPKRWLCDGANDCGSNEDESNQTCTAR----TCQVDQFSC-GNGRCIPRAWLCDRED 950
C K W CDG DC DE+N C + C QF C CIP ++ CD E
Sbjct: 335 GHCALKLWRCDGDFDCEDRTDEAN--CPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 951 DCGDQTDE 958
DC D++DE
Sbjct: 393 DCPDRSDE 400
Score = 97.1 bits (240), Expect = 4e-19
Identities = 66/211 (31%), Positives = 84/211 (39%), Gaps = 59/211 (27%)
Query: 2514 SEFECGN-GECIDYQLTCDGIPHCKDKSDEKLLYCENR---------------------- 2550
+EF C + EC+ + CD P C+D SDE L CE
Sbjct: 202 AEFACHSYNECVALEYRCDRRPDCRDMSDE--LNCEEPVLGISPTFSLLVETTSLPPRPE 259
Query: 2551 ------------------------SCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC 2586
C C N CIP LCDG+ DC D SDELDC
Sbjct: 260 TTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC 319
Query: 2587 -KVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTG--F 2643
C EF C +G C + RC+ + DC D +DE NC K + G
Sbjct: 320 GPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPT-------KRPEEVCGPTQ 372
Query: 2644 IRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
RC ST++C+ ++ CD +DC D SDE C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 85.5 bits (210), Expect = 1e-15
Identities = 63/214 (29%), Positives = 83/214 (38%), Gaps = 58/214 (27%)
Query: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERG--------------------- 3670
C E +F C + C+ + + CD DC D SDE NCE
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3671 -------------------GNI----CRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEA- 3706
G++ C E C N C ++CDG++DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 3707 ---PDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCK 3763
P C P+ P C N L+ + C+G +C D +DE +C K + C
Sbjct: 319 CGPPPPCE----PNEFP--CGNGHCALKLWR-CDGDFDCEDRTDEANCPTKRPEEV--CG 369
Query: 3764 KDEFAC-SNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
+F C S CIP CD DC D SDE GC
Sbjct: 370 PTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 60.8 bits (146), Expect = 3e-08
Identities = 32/79 (40%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP-EEVEIKCPLNHIACLGTNKC 90
C+P EF C + C + W CDGD DC D +DE+ CP + E C C+ TN C
Sbjct: 325 CEPNEFPCGNG-HCALKLWRCDGDFDCEDRTDEA--NCPTKRPEEVCGPTQFRCVSTNMC 381
Query: 91 VHLSQLCNGVLDCPDGYDE 109
+ S C+ DCPD DE
Sbjct: 382 IPASFHCDEESDCPDRSDE 400
Score = 56.6 bits (135), Expect = 6e-07
Identities = 27/54 (50%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 3761 PCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGD 3814
PC E AC N CIP D CD +DC DGSDE C P CE N PCG+
Sbjct: 284 PCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP---PCEPNEFPCGN 334
Score = 52.8 bits (125), Expect = 8e-06
Identities = 44/155 (28%), Positives = 60/155 (38%), Gaps = 16/155 (10%)
Query: 2438 DTKILRSD-IPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRI 2496
+T I+R + H P ++ + C A NG C L +G+ +C D +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLC-DGQEDCEDGSDEL 317
Query: 2497 LLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRR-- 2554
N EF CGNG C CDG C+D++DE C +
Sbjct: 318 DCGPPPPCEPN-------EFPCGNGHCALKLWRCDGDFDCEDRTDE--ANCPTKRPEEVC 368
Query: 2555 ---GFKPCYNRRCIPHGKLCDGENDCGDNSDELDC 2586
F+ CIP CD E+DC D SDE C
Sbjct: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 48.9 bits (115), Expect = 1e-04
Identities = 30/78 (38%), Positives = 35/78 (44%), Gaps = 6/78 (7%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P E C + C+ + +LCDG DC D SDE LD P C N C G C
Sbjct: 285 CGPQEAACRNG-HCIPRDYLCDGQEDCEDGSDE-LDCGPPP---PCEPNEFPC-GNGHCA 338
Query: 92 HLSQLCNGVLDCPDGYDE 109
C+G DC D DE
Sbjct: 339 LKLWRCDGDFDCEDRTDE 356
Score = 47.0 bits (110), Expect = 4e-04
Identities = 28/73 (38%), Positives = 36/73 (49%), Gaps = 5/73 (6%)
Query: 4221 CENGGRCILNEKGDLRCHCWPSYSGERCEVN---HC-SNYCQNGGTCVPSVLGRP-TCSC 4275
C+NGG+C +E C C ++G RCE + HC C TCV GR TC C
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4276 ALGFTGPNCGKTV 4288
LG +G C + V
Sbjct: 3913 HLGRSGLRCEEGV 3925
Score = 46.6 bits (109), Expect = 6e-04
Identities = 36/142 (25%), Positives = 51/142 (35%), Gaps = 53/142 (37%)
Query: 1098 KTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS------------------------ 1133
+ +F+C S C+ + CD DC D SDE +C+
Sbjct: 201 EAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPET 260
Query: 1134 ----------------------FLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGY 1171
CGP + C N C+ + LC+G++DC DGSDE
Sbjct: 261 TIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN--GHCIPRDYLCDGQEDCEDGSDE-L 317
Query: 1172 LC---DECSLNNGGCSN-HCSV 1189
C C N C N HC++
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCAL 339
Score = 45.1 bits (105), Expect = 0.002
Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 16/86 (18%)
Query: 4205 GTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQ------ 4258
G C D S + + C++G C+ + + +C C + G+ CE H N CQ
Sbjct: 4100 GQCYDSSPCE---RQPCQHGATCMPAGEYEFQCLCRDGFKGDLCE--HEENPCQLREPCL 4154
Query: 4259 NGGTCVPSVLGRPTCSCALGFTGPNC 4284
+GGTC + C C GF+GP C
Sbjct: 4155 HGGTCQGT-----RCLCLPGFSGPRC 4175
Score = 45.1 bits (105), Expect = 0.002
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 9/69 (13%)
Query: 4257 CQNGGTCVPSVLGRPTCSCALGFTGPNC--GKTVCE--DFCQNGGTCIVTAGNQPYCHCQ 4312
CQ+G TC+P+ C C GF G C + C+ + C +GGTC T C C
Sbjct: 4113 CQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTR-----CLCL 4167
Query: 4313 PEYTGDRCQ 4321
P ++G RCQ
Sbjct: 4168 PGFSGPRCQ 4176
Score = 44.3 bits (103), Expect = 0.003
Identities = 33/118 (27%), Positives = 41/118 (34%), Gaps = 40/118 (33%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE---------------------SLDTCP 70
C EF CH + CV+ + CD PDC D SDE SL P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 71 EEVEIK-CPLNHI------------------ACLGTNKCVHLSQLCNGVLDCPDGYDE 109
E ++ P+ H A C+ LC+G DC DG DE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Score = 43.5 bits (101), Expect = 0.005
Identities = 19/70 (27%), Positives = 27/70 (38%), Gaps = 6/70 (8%)
Query: 4329 CVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCH------GGHCIINKDSEDIFCNC 4382
C N C + S CVCP + G +CE + + CH C+ D C C
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4383 TNGKIASSCQ 4392
G+ C+
Sbjct: 3913 HLGRSGLRCE 3922
Score = 42.7 bits (99), Expect = 0.008
Identities = 47/166 (28%), Positives = 63/166 (37%), Gaps = 47/166 (28%)
Query: 4273 CSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNS 4332
CSC G+ GP+C C G T + C +RC CH + S
Sbjct: 1126 CSCPPGYRGPSCQD------CDTGYTRTPSGLYLGTC--------ERCS---CHGH---S 1165
Query: 4333 ESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ 4392
E+C + G+ + C EGP+CE +C G+ + + G CQ
Sbjct: 1166 EACE-PETGACQG-CQHHTEGPRCE-----QCQPGY----------YGDAQRGT-PQDCQ 1207
Query: 4393 LCDGYCYN-------GGTCQLDPETNVPVCLCSTNWSGTQCERPAP 4431
LC CY TC LD + + CS SG CER AP
Sbjct: 1208 LCP--CYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAP 1251
Score = 42.7 bits (99), Expect = 0.008
Identities = 25/81 (30%), Positives = 33/81 (40%), Gaps = 9/81 (11%)
Query: 4250 VNHCSNY----CQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVC----EDFCQNGGTCIV 4301
++HC CQNGG C S C C GFTG C + + C TC+
Sbjct: 3842 ISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVN 3901
Query: 4302 TAGNQPY-CHCQPEYTGDRCQ 4321
+ Y C C +G RC+
Sbjct: 3902 RPDGRGYTCRCHLGRSGLRCE 3922
Score = 42.0 bits (97), Expect = 0.014
Identities = 21/48 (43%), Positives = 28/48 (58%), Gaps = 6/48 (12%)
Query: 3760 RPCKKDEFAC-SNKKCIPMDLQCDRLDDCGDGSDEQGCR-----IAPT 3801
R C + EFAC S +C+ ++ +CDR DC D SDE C I+PT
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPT 244
Score = 41.2 bits (95), Expect = 0.024
Identities = 16/38 (42%), Positives = 23/38 (60%)
Query: 27 RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
R +++C P +F C C+ S+ CD + DCPD SDE
Sbjct: 363 RPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 41.2 bits (95), Expect = 0.024
Identities = 56/205 (27%), Positives = 72/205 (35%), Gaps = 50/205 (24%)
Query: 4236 RCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCS-CALGFTGPNC-GKTVCEDFC 4293
+C C P Y G C+ C G T PS L TC C+ C +T C
Sbjct: 1125 QCSCPPGYRGPSCQ------DCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGC 1178
Query: 4294 QNGGTCIVTAGNQPYC-HCQPEYTGDR-------CQYYVCHHYCVNSE---SCTIGDDGS 4342
Q+ T G P C CQP Y GD CQ C+ + +C + DG
Sbjct: 1179 QHH-----TEG--PRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGH 1231
Query: 4343 VEC-VCPTRYEGPKCEVDKCVRCHGGHC-------IINKDSE---DIFCNC-TNGKIASS 4390
C C + G CE RC G+ +DS+ I CNC G ++S
Sbjct: 1232 PTCDACSPGHSGRHCE-----RCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQ 1286
Query: 4391 CQLCDGYCYNGGTCQLDPETNVPVC 4415
C G CQ + C
Sbjct: 1287 CDA-------AGQCQCKAQVEGLTC 1304
Score = 40.0 bits (92), Expect = 0.054
Identities = 19/66 (28%), Positives = 31/66 (46%), Gaps = 3/66 (4%)
Query: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDD-GSVECVCPTRY 4351
CQ+G TC+ + C C+ + GD C++ + C E C G C+C +
Sbjct: 4113 CQHGATCMPAGEYEFQCLCRDGFKGDLCEHE--ENPCQLREPCLHGGTCQGTRCLCLPGF 4170
Query: 4352 EGPKCE 4357
GP+C+
Sbjct: 4171 SGPRCQ 4176
Score = 39.7 bits (91), Expect = 0.070
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 5/70 (7%)
Query: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQY---YVCH-HYCVNSESCTIGDDG-SVECVC 4347
CQNGG C + + C C +TG RC++ CH C +C DG C C
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4348 PTRYEGPKCE 4357
G +CE
Sbjct: 3913 HLGRSGLRCE 3922
Score = 38.9 bits (89), Expect = 0.12
Identities = 34/112 (30%), Positives = 44/112 (39%), Gaps = 21/112 (18%)
Query: 4146 GSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLING 4205
G V +D T L S Q +PC C+ GATC+ P G+Y
Sbjct: 4078 GEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQH-------GATCM-PAGEYEFQC 4129
Query: 4206 TCNDDSLLD------DSCKLT--CENGGRCILNEKGDLRCHCWPSYSGERCE 4249
C D D + C+L C +GG C RC C P +SG RC+
Sbjct: 4130 LCRDGFKGDLCEHEENPCQLREPCLHGGTC-----QGTRCLCLPGFSGPRCQ 4176
Score = 38.1 bits (87), Expect = 0.20
Identities = 20/44 (45%), Positives = 23/44 (52%), Gaps = 7/44 (15%)
Query: 3317 CTASQFRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQP 3359
C +QFRC T+ CIP + CD DC D SDE F C P
Sbjct: 368 CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE------FGCMP 405
Score = 36.6 bits (83), Expect = 0.59
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 2/40 (5%)
Query: 4389 SSCQLC-DGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
S C C D C NGG C D E++ VC+C ++G++CE
Sbjct: 3843 SHCPTCRDRPCQNGGQCH-DSESSSYVCVCPAGFTGSRCE 3881
Score = 35.8 bits (81), Expect = 1.0
Identities = 28/122 (22%), Positives = 41/122 (33%), Gaps = 19/122 (15%)
Query: 4227 CILNEKGDLRCH-CWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCG 4285
C L+ G C C P +SG CE C P G P+ G
Sbjct: 1224 CFLDTDGHPTCDACSPGHSGRHCE------------RCAPGYYGNPSQGQPCQRDSQVPG 1271
Query: 4286 KTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVEC 4345
C C G+ C C+ + G C + HH+ +++ + DG + C
Sbjct: 1272 PIGCN--CDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASN----PDGCLPC 1325
Query: 4346 VC 4347
C
Sbjct: 1326 FC 1327
Score = 35.0 bits (79), Expect = 1.7
Identities = 29/99 (29%), Positives = 42/99 (42%), Gaps = 22/99 (22%)
Query: 4337 IGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNG-------KIAS 4389
+G G +C Y+ CE C HG C+ + E C C +G +
Sbjct: 4094 LGSQGIGQC-----YDSSPCERQPCQ--HGATCMPAGEYE-FQCLCRDGFKGDLCEHEEN 4145
Query: 4390 SCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCER 4428
CQL + C +GGTCQ CLC +SG +C++
Sbjct: 4146 PCQLREP-CLHGGTCQGTR------CLCLPGFSGPRCQQ 4177
Score = 33.9 bits (76), Expect = 3.8
Identities = 34/127 (26%), Positives = 46/127 (36%), Gaps = 39/127 (30%)
Query: 4344 ECVCPTRYEGPKCE--------------VDKC--VRCHG---------GHCI-INKDSED 4377
EC CP Y G CE + C C+G GHC+ ++E
Sbjct: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
Query: 4378 IFCN-CTNG-------KIASSCQLC-----DGYCYNGGTCQLDPETNVPVCLCSTNWSGT 4424
CN C G A+SC+ C D TC LD + C+ ++G
Sbjct: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGR 849
Query: 4425 QCERPAP 4431
+CE AP
Sbjct: 850 RCESCAP 856
Score = 33.9 bits (76), Expect = 3.8
Identities = 38/146 (26%), Positives = 46/146 (31%), Gaps = 42/146 (28%)
Query: 4194 CVCPEGKYLINGTCND---------DSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYS 4244
C CP G I +C D L C+L C N DL C P
Sbjct: 1530 CRCPPG--YIGLSCQDCAPGYTRTGSGLYLGHCEL-------CECNGHSDL---CHPETG 1577
Query: 4245 G-ERCEVNHCSNYCQNGGTCVPSVLGRPTCS-------CALGFTGP-NCGKTVCEDFCQN 4295
+C+ N +C+ C P G T CA T P N CE
Sbjct: 1578 ACSQCQHNAAGEFCE---LCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAG 1634
Query: 4296 GGTCIVTAGNQPYCHCQPEYTGDRCQ 4321
G C C+P YTG C+
Sbjct: 1635 GYRCTA---------CEPGYTGQYCE 1651
Score = 33.1 bits (74), Expect = 6.5
Identities = 52/204 (25%), Positives = 67/204 (32%), Gaps = 58/204 (28%)
Query: 4237 CHCWPSYSGERCE--------------VNHCSNYCQNG--GTCVPSVLGR---------- 4270
C C YSG CE + CS NG +C P V G
Sbjct: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDP-VYGHCLNCQHNTEG 789
Query: 4271 PTCS-CALGF-------TGPNCGKTVCEDFCQN---GGTCIVTAGNQPYCH-CQPEYTGD 4318
P C+ C GF T +C C + TC + Q C C P YTG
Sbjct: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGR 849
Query: 4319 RCQYYVCHHYCVNSESCTIGDDGSV-----ECVCPTRYEGPKCEVDKCVRCHGGHCIINK 4373
RC ESC G +G+ +C P E +C+ + G C
Sbjct: 850 RC------------ESCAPGYEGNPIQPGGKC-RPVNQEIVRCDERGSMGTSGEACRCKN 896
Query: 4374 DSEDIFCN-CTNGKIASSCQLCDG 4396
+ CN C +G S + DG
Sbjct: 897 NVVGRLCNECADGSFHLSTRNPDG 920
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 138 bits (348), Expect = 1e-31
Identities = 77/217 (35%), Positives = 103/217 (47%), Gaps = 30/217 (13%)
Query: 4217 CKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCA 4276
C C+N G+CI K ++ C C P + G C+ HC+ CQ+GGTC+ L C+C
Sbjct: 1330 CDPDCKNHGKCI---KPNI-CQCLPGHGGATCDEEHCNPPCQHGGTCLAGNL----CTCP 1381
Query: 4277 LGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCT 4336
GF GP C VC C+NGG C+ C C+P + G C +C C+N SC
Sbjct: 1382 YGFVGPRCETMVCNRHCENGGQCL----TPDICQCKPGWYGPTCSTALCDPVCLNGGSCN 1437
Query: 4337 IGDDGSVECVCPTRYEGPKCEVDKC-VRC-HGGHCIINKDSEDIFCNCTNGKIASSCQ-- 4392
+ C+CP + G C+ C C +GGHC+ N C C G Q
Sbjct: 1438 KPN----TCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNN-----VCVCREGYTGRRFQKS 1488
Query: 4393 LCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERP 4429
+CD C NGG C + P T C C + WSG +C P
Sbjct: 1489 ICDPTCMNGGKC-VGPST----CSCPSGWSGKRCNTP 1520
Score = 127 bits (318), Expect = 3e-28
Identities = 79/244 (32%), Positives = 111/244 (45%), Gaps = 39/244 (15%)
Query: 4190 SGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCE 4249
+G C CP G + C ++++ C CENGG+C+ + C C P + G C
Sbjct: 1374 AGNLCTCPYG--FVGPRC--ETMV---CNRHCENGGQCLTPDI----CQCKPGWYGPTCS 1422
Query: 4250 VNHCSNYCQNGGTCVPSVLGRP-TCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPY 4308
C C NGG+C +P TC C GF G +C C C+NGG C+
Sbjct: 1423 TALCDPVCLNGGSC-----NKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCM----RNNV 1473
Query: 4309 CHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCV-RC-HG 4366
C C+ YTG R Q +C C+N C G C CP+ + G +C C+ +C +G
Sbjct: 1474 CVCREGYTGRRFQKSICDPTCMNGGKCV----GPSTCSCPSGWSGKRCNTPICLQKCKNG 1529
Query: 4367 GHCIINKDSEDIFCNCTNGKIASSCQL--CDGYCYNGGTCQLDPETNVPVCLCSTNWSGT 4424
G CI C+C + CQ+ C+ C GG C + P VC C T +SG
Sbjct: 1530 GECIAPS-----ICHCPSSWEGVRCQIPICNPKCLYGGRC-IFPN----VCSCRTEYSGV 1579
Query: 4425 QCER 4428
+CE+
Sbjct: 1580 KCEK 1583
Score = 112 bits (280), Expect = 8e-24
Identities = 64/193 (33%), Positives = 86/193 (44%), Gaps = 26/193 (13%)
Query: 4176 CLDLACEFLCLLNPS---GATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEK 4232
C C+ +CL S TC+CP G + + + C C+NGG C+ N
Sbjct: 1421 CSTALCDPVCLNGGSCNKPNTCLCPNGFF-------GEHCQNAFCHPPCKNGGHCMRNNV 1473
Query: 4233 GDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
C C Y+G R + + C C NGG CV G TCSC G++G C +C
Sbjct: 1474 ----CVCREGYTGRRFQKSICDPTCMNGGKCV----GPSTCSCPSGWSGKRCNTPICLQK 1525
Query: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYE 4352
C+NGG CI + CHC + G RCQ +C+ C+ C + C C T Y
Sbjct: 1526 CKNGGECIAPS----ICHCPSSWEGVRCQIPICNPKCLYGGRCIFPN----VCSCRTEYS 1577
Query: 4353 GPKCEVDKCVRCH 4365
G KCE +R H
Sbjct: 1578 GVKCEKKIQIRRH 1590
Score = 94.0 bits (232), Expect = 3e-18
Identities = 60/180 (33%), Positives = 80/180 (44%), Gaps = 28/180 (15%)
Query: 4253 CSNYCQNGGTCV-PSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHC 4311
C C CV P++ C C G+ G NC +C+ C+N G CI C C
Sbjct: 1298 CKYPCGKSRECVAPNI-----CKCKPGYIGSNCQTALCDPDCKNHGKCI----KPNICQC 1348
Query: 4312 QPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVR-C-HGGHC 4369
P + G C C+ C + +C G+ C CP + GP+CE C R C +GG C
Sbjct: 1349 LPGHGGATCDEEHCNPPCQHGGTCLAGN----LCTCPYGFVGPRCETMVCNRHCENGGQC 1404
Query: 4370 IINKDSEDIFCNCTNGKIASSCQ--LCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
+ + DI C C G +C LCD C NGG+C P T CLC + G C+
Sbjct: 1405 L----TPDI-CQCKPGWYGPTCSTALCDPVCLNGGSCN-KPNT----CLCPNGFFGEHCQ 1454
Score = 36.2 bits (82), Expect = 0.77
Identities = 50/203 (24%), Positives = 72/203 (35%), Gaps = 55/203 (27%)
Query: 1052 GCNGNEFQCHPD----GNCV-PDLWRC---DGEKDCEDGSDEKGCNGTIRLCDHKTKFSC 1103
G N C PD G C+ P++ +C G C DE+ CN C H +C
Sbjct: 1322 GSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATC----DEEHCNPP---CQHGG--TC 1372
Query: 1104 WSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDC 1163
+ C C C++ +C +H C N CL P+ +C K
Sbjct: 1373 LAGNLCT-----------CPYGFVGPRCETMVCN--RH-CENGGQ-CLTPD-ICQCKPGW 1416
Query: 1164 PDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK 1223
+ LCD LN G C+ + C CP G ++C N
Sbjct: 1417 YGPTCSTALCDPVCLNGGSCN--------KPNTCLCPNGF----------FGEHCQNAF- 1457
Query: 1224 CSQVCEQHKHTVK---CSCYEGW 1243
C C+ H ++ C C EG+
Sbjct: 1458 CHPPCKNGGHCMRNNVCVCREGY 1480
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 134 bits (338), Expect = 2e-30
Identities = 98/330 (29%), Positives = 129/330 (39%), Gaps = 55/330 (16%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE--------PDDCPEFR-CQPGRFQCGT 3366
NC QFRC KCIP WKC+ +D+CGD SDE P F+ C +FQC +
Sbjct: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
Query: 3367 GL-----CALPAFICDGENDCGDNSDELNCDTHVC------LSGQFKCTKNQKCIPVNLR 3415
C + CDG DC D DE++CD C G F P
Sbjct: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
Query: 3416 CNGQDDCGDEEDE----RDCP-ENSCSPDYFQC----KTTKHCISKLWVCDEDPD----- 3461
C D GD D + + DY + + H + ++ +
Sbjct: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
Query: 3462 ----------CADASDEANCDKKT------CGPHEFQCKNN-NCIPDHWRCDSQNDCSDN 3504
CAD + A T C P E C N C + RCD C +
Sbjct: 326 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 385
Query: 3505 SDEENCKPQTCTLKDFLCA-NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNG 3563
DE NC C ++F C+ NG C C+ C +GSDE+NC C F C N
Sbjct: 386 RDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-FFCQPGNFHCKNN 442
Query: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPT 3593
+C+ W CD +DC G DE++C PT
Sbjct: 443 RCVFESWVCDSQDDCGDGSDEENCPVIVPT 472
Score = 126 bits (317), Expect = 4e-28
Identities = 102/327 (31%), Positives = 138/327 (42%), Gaps = 62/327 (18%)
Query: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS----------CSPDYFQC-- 3443
C QF+C N KCIP +CN D+CGD DE C + + C+ + FQC
Sbjct: 147 CACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
Query: 3444 KTTK--HCISKLWVCDEDPDCADASDEANCDKKTCGPH--------------EFQCKNNN 3487
+ TK C+ + CD + DC D DE +CD TCG +F +N
Sbjct: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
Query: 3488 CI-----PDHWRC-----DSQNDCSDNSD--------EENCKPQTCTLKDFLC-ANGDCV 3528
C DH + D + D + D EEN L F A V
Sbjct: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
Query: 3529 SSR-----FWCDGDFDCADGSDER-NCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYG 3581
SS +C + A G + + C + C N C + +CDG+ C G
Sbjct: 326 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 385
Query: 3582 EDEKSCEPASPTCSSREYICASDG-CISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK 3640
DE +C C E+ C+ +G C S +CN + C +GSDE +C C+ F CK
Sbjct: 386 RDETNCT----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCK 440
Query: 3641 NKAHCIPIRWLCDGIHDCVDGSDEENC 3667
N C+ W+CD DC DGSDEENC
Sbjct: 441 NN-RCVFESWVCDSQDDCGDGSDEENC 466
Score = 126 bits (316), Expect = 6e-28
Identities = 104/374 (27%), Positives = 146/374 (39%), Gaps = 62/374 (16%)
Query: 2488 NCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYC 2547
N S +G R+ + N +C+ +F CGNG+CI C+ + C D SDE++
Sbjct: 127 NISRKGFRLAYFSGKSEEPNCACD---QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 183
Query: 2548 E-NRSCRRGFKPC-YNR-----------RCIPHGKLCDGENDCGDNSDELDCKVSTCATV 2594
E N F+PC YN+ C+P CDG DC D DE+DC V TC
Sbjct: 184 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQ- 242
Query: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVL 2654
+ GT N+ + FY G T I +L
Sbjct: 243 WLKYFYGT----------------------FNSPNYPDFYPPGSNCTWLIDTGDHRKVIL 280
Query: 2655 --PTWICDGSNDCGDYSDELKCPVQNKHKC--------EENYFSCPSGRCILNTWICDGQ 2704
+ DG+ GDY +N HK + S + C +
Sbjct: 281 RFTDFKLDGTG-YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADK 339
Query: 2705 KDCEDG-RDEFHCDSSCSWNQFACSAQ-KCISKHWICDGEDDCGDGLDESDSICGAITCA 2762
+ G + D C + C C ++ CDG C +G DE++ C
Sbjct: 340 VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN----CTMCQ 395
Query: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
+ F C + C PR C+ + CP+GSDE + C P N F C N C+ + +
Sbjct: 396 KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGN------FHCKNNRCVFESW 449
Query: 2823 VCDHDDDCGDGSDE 2836
VCD DDCGDGSDE
Sbjct: 450 VCDSQDDCGDGSDE 463
Score = 116 bits (291), Expect = 5e-25
Identities = 95/327 (29%), Positives = 134/327 (40%), Gaps = 61/327 (18%)
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT----------CGPHEFQ 3482
E +C+ D F+C K CI + W C+ +C D+SDE C K+ C ++FQ
Sbjct: 144 EPNCACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
Query: 3483 C-----KNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC--TLKDFLCANGDCVSSRFWCD 3535
C K C+P+ +CD DC D DE +C TC LK F F+
Sbjct: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
Query: 3536 GDFDCA---DGSDERNC---ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
G +C D D R T D + I + + H+ + S P
Sbjct: 263 GS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
Query: 3590 ASPTCSS---REYICAS--------------DG-CISASLKCNGE-------------YD 3618
+ SS R + CA DG C+ + C G +
Sbjct: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 381
Query: 3619 CADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE 3678
C +G DE +C T C++++F C C P C+ + C +GSDE+NC C+
Sbjct: 382 CPNGRDETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGN 436
Query: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
F C N+ C WVCD +DDCGD SDE
Sbjct: 437 FHCKNNRCVFESWVCDSQDDCGDGSDE 463
Score = 107 bits (267), Expect = 3e-22
Identities = 91/313 (29%), Positives = 131/313 (41%), Gaps = 68/313 (21%)
Query: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC--EPASPT------CSSREYIC 3601
E +C+ DQFRC NG+CIP WKC+ ++C DE+ C E PT C+ ++ C
Sbjct: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 203
Query: 3602 ASD-----GCISASLKCNGEYDCADGSDEMDC-VTECKE------DQFRCKNKAHCIP-- 3647
S C+ SLKC+G DC D DE+DC V C + F N P
Sbjct: 204 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
Query: 3648 --IRWLCD-GIHDCV---------DGSD-----------EENCERGGNICRADE------ 3678
WL D G H V DG+ EEN + + A +
Sbjct: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
Query: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPD-MCVKFLCPSTRPHRCRNNRICLQSEQMCN 3737
+ ++ ++HF G N+ D C+ + P C N C +Q C+
Sbjct: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIP------CGGNWGCYTEQQRCD 377
Query: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACS-NKKCIPMDLQCDRLDDCGDGSDEQGC 3796
G C + DE +C C+K+EF CS N C P +C+ + C +GSDE+ C
Sbjct: 378 GYWHCPNGRDETNC--------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
Query: 3797 RIA-PTEYTCEDN 3808
P + C++N
Sbjct: 430 FFCQPGNFHCKNN 442
Score = 107 bits (266), Expect = 4e-22
Identities = 93/345 (26%), Positives = 137/345 (39%), Gaps = 86/345 (24%)
Query: 3472 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP----------QTCTLKDFL 3521
++ C +F+C N CIP+ W+C++ ++C D+SDEE C Q C F
Sbjct: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
Query: 3522 CANG-----DCVSSRFWCDGDFDCADGSDERNCET-SCS---KDQFRCSNGQCIP----- 3567
C + C+ CDG+ DC D DE +C+ +C K + N P
Sbjct: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
Query: 3568 ---AKWKCDGHEDCK--------------YGEDEK--------------------SCEPA 3590
W D + K YG+ K S P
Sbjct: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 322
Query: 3591 SPTCSS---REYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
+ SS R + CA ++A+ N Y DG C + C C
Sbjct: 323 TVVSSSGQIRVHFCADK--VNAARGFNATYQ-VDGF--------CLPWEIPCGGNWGCYT 371
Query: 3648 IRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN-NSLCKLHFWVCDGEDDCGDNSDEA 3706
+ CDG C +G DE NC +C+ +EF C+ N +C C+ ++ C + SDE
Sbjct: 372 EQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE- 426
Query: 3707 PDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
C F C H C+NNR C+ +C+ D+CGD SDE++C
Sbjct: 427 -KNC--FFCQPGNFH-CKNNR-CVFESWVCDSQDDCGDGSDEENC 466
Score = 105 bits (262), Expect = 1e-21
Identities = 90/337 (26%), Positives = 134/337 (39%), Gaps = 71/337 (21%)
Query: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE------SNQTCTA--RTCQVDQFSCGN 936
+C DQF+C N +CIP+ W C+ ++CG + DE +N A + C +QF C +
Sbjct: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
Query: 937 G-----RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRC----------I 981
C+P + CD DC D DE+ C+ PTC ++ +
Sbjct: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
Query: 982 SSKWHCDSDDD----------------------CGDGSDE----VGCVHSCFDNQFRC-- 1013
+ W D+ D DG +E + V + FD+
Sbjct: 265 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 324
Query: 1014 -SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWR 1072
SS I H+ D N F+ Q++ C E C + C + R
Sbjct: 325 VSSSGQIRVHFCADKVNAARGFNATYQVD---------GFCLPWEIPCGGNWGCYTEQQR 375
Query: 1073 CDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 1132
CDG C +G DE C +C K +F C G C ++ C+ C + SDE +C
Sbjct: 376 CDGYWHCPNGRDETNCT----MC-QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 429
Query: 1133 SFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
F C P C N+ C+ +C+ + DC DGSDE
Sbjct: 430 -FFCQPGNFHCKNNR--CVFESWVCDSQDDCGDGSDE 463
Score = 98.2 bits (243), Expect = 2e-19
Identities = 95/365 (26%), Positives = 129/365 (35%), Gaps = 85/365 (23%)
Query: 826 LDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHS 885
+ G + G++ C +FRC N CI WKC+ D+C D SDE+ C +
Sbjct: 128 ISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEA 185
Query: 886 ----------CPDDQFKCQNN-----RCIPKRWLCDGANDC---GSNEDESNQTC----- 922
C +QF+C + C+P+ CDG DC G D TC
Sbjct: 186 NPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLK 245
Query: 923 ----TARTCQVDQFSCGNGRCIPRAWLCDREDD----------------CGDQT---DEM 959
T + F C WL D D GD D +
Sbjct: 246 YFYGTFNSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 302
Query: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
LT F + + S C D + ++ + G C+
Sbjct: 303 EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ-----VDGFCL 357
Query: 1020 P------GHWAC-------DGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNC 1066
P G+W C DG C + DE NCT C EF C +G C
Sbjct: 358 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVC 407
Query: 1067 VPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQS 1126
P RC+ + C +GSDEK C F C RC+ ++WVCD DC D S
Sbjct: 408 YPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHC-KNNRCVFESWVCDSQDDCGDGS 461
Query: 1127 DEDDC 1131
DE++C
Sbjct: 462 DEENC 466
Score = 89.7 bits (221), Expect = 6e-17
Identities = 95/359 (26%), Positives = 128/359 (35%), Gaps = 83/359 (23%)
Query: 2620 SDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNK 2679
S+E NC C F RC + C+ W C+ ++CGD SDE C +
Sbjct: 142 SEEPNCA---CDQF-----------RCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEAN 186
Query: 2680 -------HKCEENYFSCPSG-----RCILNTWICDGQKDCEDGRDEFHCD---------- 2717
C N F C S C+ + CDG DC D DE CD
Sbjct: 187 PPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKY 246
Query: 2718 -----------------SSCSWNQFACSAQKCISKH--WICDGED-----DCGDGLDESD 2753
S+C+W +K I + + DG DGL+E+
Sbjct: 247 FYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENP 306
Query: 2754 SICGAITCAADM---FSCQGSRACVPRHWLCDGERDCPDGSDELSTAG-CAP-NNTCDEN 2808
+ A D + S + H+ D + G C P C N
Sbjct: 307 HKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 366
Query: 2809 AFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGD 2868
C +Q CD C +G DE+ C EEF C+ +C+
Sbjct: 367 WG------CYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQ 417
Query: 2869 FDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHI 2927
CP+ SDE C C F CKN RC+ +CD++DDCGDGSDE NC +
Sbjct: 418 NHCPNGSDEK----NCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 468
Score = 83.6 bits (205), Expect = 4e-15
Identities = 47/121 (38%), Positives = 60/121 (49%), Gaps = 16/121 (13%)
Query: 2558 PCY-NRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCA-DGTCIPRSARCNQNID 2615
PC N C + CDG C + DE +C + C EF C+ +G C PRS RCN
Sbjct: 362 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNH 419
Query: 2616 CADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCP 2675
C + SDEKNC +F+ C + CV +W+CD +DCGD SDE CP
Sbjct: 420 CPNGSDEKNCFFCQPGNFH-----------CKNNR-CVFESWVCDSQDDCGDGSDEENCP 467
Query: 2676 V 2676
V
Sbjct: 468 V 468
Score = 80.5 bits (197), Expect = 4e-14
Identities = 57/181 (31%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 784 LQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG----RVCACADNQLLDENGTTCTFNPGE 839
++IYD ++ + RV S L + RV CAD FN
Sbjct: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV-----NAARGFNATY 350
Query: 840 ALPHICKAGEFRCK-NRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC-QNNR 897
+ C E C N C + +CDG C +G DE NC C ++F C +N
Sbjct: 351 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNC--TMCQKEEFPCSRNGV 406
Query: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTD 957
C P+ C+ N C + DE N CQ F C N RC+ +W+CD +DDCGD +D
Sbjct: 407 CYPRSDRCNYQNHCPNGSDEKN----CFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSD 462
Query: 958 E 958
E
Sbjct: 463 E 463
Score = 75.5 bits (184), Expect = 1e-12
Identities = 71/286 (24%), Positives = 108/286 (37%), Gaps = 61/286 (21%)
Query: 2512 AYSEFECGNG-----ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIP 2566
AY++F+C + C+ L CDG C D DE + C+ +C + K Y P
Sbjct: 197 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSP 254
Query: 2567 H-------GKLCDGENDCGDNSDEL----DCKVSTCATVEF-RCADG------------- 2601
+ G C D GD+ + D K+ ++ + DG
Sbjct: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
Query: 2602 --------TCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGF-----IRCNS 2648
T + S + + CAD + + + GF I C
Sbjct: 315 AFDSHAPLTVVSSSGQIRVHF-CAD--------KVNAARGFNATYQVDGFCLPWEIPCGG 365
Query: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCP-SGRCILNTWICDGQKDC 2707
C CDG C + DE C + C++ F C +G C + C+ Q C
Sbjct: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGVCYPRSDRCNYQNHC 420
Query: 2708 EDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
+G DE +C C F C +C+ + W+CD +DDCGDG DE +
Sbjct: 421 PNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEEN 465
Score = 70.5 bits (171), Expect = 4e-11
Identities = 51/157 (32%), Positives = 64/157 (40%), Gaps = 27/157 (17%)
Query: 3655 IHDCVDGSDEENCERGGN-------ICRADEFLCNNSL-CKLHFWVCDGEDDCGDNSDEA 3706
+H C +D+ N RG N C E C + C CDG C + DE
Sbjct: 333 VHFC---ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET 389
Query: 3707 P-DMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKD 3765
MC K P C N +C CN + C + SDE +C C+
Sbjct: 390 NCTMCQKEEFP------CSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--------CQPG 435
Query: 3766 EFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR-IAPT 3801
F C N +C+ CD DDCGDGSDE+ C I PT
Sbjct: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 472
Score = 68.6 bits (166), Expect = 1e-10
Identities = 40/113 (35%), Positives = 51/113 (45%), Gaps = 8/113 (7%)
Query: 2515 EFECG-NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC-YNRRCIPHGKLCD 2572
E CG N C Q CDG HC + DE C++ PC N C P C+
Sbjct: 360 EIPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCTMCQKEEFPCSRNGVCYPRSDRCN 415
Query: 2573 GENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
+N C + SDE +C C F C + C+ S C+ DC D SDE+NC
Sbjct: 416 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 67.4 bits (163), Expect = 3e-10
Identities = 37/127 (29%), Positives = 50/127 (39%), Gaps = 17/127 (13%)
Query: 2591 CATVEFRCADGT-CIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNST 2649
C E C C RC+ C + DE NC F C+
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEF-----------PCSRN 404
Query: 2650 SLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCED 2709
+C + C+ N C + SDE C C+ F C + RC+ +W+CD Q DC D
Sbjct: 405 GVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNRCVFESWVCDSQDDCGD 459
Query: 2710 GRDEFHC 2716
G DE +C
Sbjct: 460 GSDEENC 466
Score = 67.0 bits (162), Expect = 4e-10
Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 3315 SNCTASQ---FRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCA 3370
+NCT Q F C + C P +C+ + C +GSDE + C F CQPG F C C
Sbjct: 389 TNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN-C--FFCQPGNFHCKNNRCV 445
Query: 3371 LPAFICDGENDCGDNSDELNC 3391
+++CD ++DCGD SDE NC
Sbjct: 446 FESWVCDSQDDCGDGSDEENC 466
Score = 65.9 bits (159), Expect = 9e-10
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 20/105 (19%)
Query: 3346 SDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHV---------- 3395
S+EP+ C +F+CG G C A+ C+ ++CGD+SDE C
Sbjct: 142 SEEPN------CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
Query: 3396 CLSGQFKC----TKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
C QF+C TK C+P +L+C+G DC D DE DC +C
Sbjct: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
Score = 57.8 bits (138), Expect = 2e-07
Identities = 34/104 (32%), Positives = 45/104 (43%), Gaps = 22/104 (21%)
Query: 2503 CVTKNSSCNAY-----------------SEFECG-NGECIDYQLTCDGIPHCKDKSDEKL 2544
C T+ C+ Y EF C NG C C+ HC + SDEK
Sbjct: 369 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 428
Query: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKV 2588
+ C+ G C N RC+ +CD ++DCGD SDE +C V
Sbjct: 429 CFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 468
Score = 56.6 bits (135), Expect = 6e-07
Identities = 43/126 (34%), Positives = 53/126 (42%), Gaps = 36/126 (28%)
Query: 2885 KSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC-----------------HI 2927
KS E +C F C NG+CIP C+N D+CGD SDE C +
Sbjct: 141 KSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 200
Query: 2928 NECLSK--KVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFP-CSQQCI 2983
+CLS+ KV C LP S KC D C+D+ DE P C Q
Sbjct: 201 FQCLSRFTKVYTC------LPESLKC---------DGNIDCLDLGDEIDCDVPTCGQWLK 245
Query: 2984 NTYGTY 2989
YGT+
Sbjct: 246 YFYGTF 251
Score = 52.0 bits (123), Expect = 1e-05
Identities = 29/92 (31%), Positives = 38/92 (41%), Gaps = 11/92 (11%)
Query: 790 RKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGE 849
R + MC+ CS + P C ++ + C F C+ G
Sbjct: 386 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 436
Query: 850 FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
F CKN C+ W CD DDC DGSDE+ NC
Sbjct: 437 FHCKNNRCVFESWVCDSQDDCGDGSDEE--NC 466
Score = 50.4 bits (119), Expect = 4e-05
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY-CNQ 3820
C D+F C N KCIP +C+ +D+CGD SDE+ C T PC + + C
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA-AFQPCAYNQFQCLS 205
Query: 3821 IKTSVFCRCKPGFQRNMKNRQCEDLNE 3847
T V+ C P + N C DL +
Sbjct: 206 RFTKVY-TCLPESLKCDGNIDCLDLGD 231
Score = 47.4 bits (111), Expect = 3e-04
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK-- 1140
S+E C CD +F C G+CI +AW C+ +C D SDE+ C PP
Sbjct: 142 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKE-ANPPTAA 191
Query: 1141 --HPCANDTSVCLQ---------PEKL-CNGKKDCPDGSDE 1169
PCA + CL PE L C+G DC D DE
Sbjct: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE 232
Score = 46.2 bits (108), Expect = 7e-04
Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 9/109 (8%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P E C + C ++ CDG CP+ DE+ T ++ E C N + C
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGV-------CY 408
Query: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNCQYKCTMVRNSTRC 138
S CN CP+G DE CQ +C+ C ++ + + C
Sbjct: 409 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDC 457
Score = 44.3 bits (103), Expect = 0.003
Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP 70
C PG F C ++ CV +SW+CD DC D SDE + CP
Sbjct: 432 CQPGNFHCKNN-RCVFESWVCDSQDDCGDGSDE--ENCP 467
Score = 41.2 bits (95), Expect = 0.024
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 8/79 (10%)
Query: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
+C EF C + C +S C+ CP+ SDE C C + C N+C
Sbjct: 393 MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK--NC-----FFCQPGNFHC-KNNRC 444
Query: 91 VHLSQLCNGVLDCPDGYDE 109
V S +C+ DC DG DE
Sbjct: 445 VFESWVCDSQDDCGDGSDE 463
Score = 39.7 bits (91), Expect = 0.070
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 14/89 (15%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVE-------IKCPLNHIAC 84
C +F C + C+ ++W C+ +C D SDE + C +E C N C
Sbjct: 147 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 203
Query: 85 LG----TNKCVHLSQLCNGVLDCPDGYDE 109
L C+ S C+G +DC D DE
Sbjct: 204 LSRFTKVYTCLPESLKCDGNIDCLDLGDE 232
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 134 bits (338), Expect = 2e-30
Identities = 98/330 (29%), Positives = 129/330 (39%), Gaps = 55/330 (16%)
Query: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE--------PDDCPEFR-CQPGRFQCGT 3366
NC QFRC KCIP WKC+ +D+CGD SDE P F+ C +FQC +
Sbjct: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 3367 GL-----CALPAFICDGENDCGDNSDELNCDTHVC------LSGQFKCTKNQKCIPVNLR 3415
C + CDG DC D DE++CD C G F P
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
Query: 3416 CNGQDDCGDEEDE----RDCP-ENSCSPDYFQC----KTTKHCISKLWVCDEDPD----- 3461
C D GD D + + DY + + H + ++ +
Sbjct: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
Query: 3462 ----------CADASDEANCDKKT------CGPHEFQCKNN-NCIPDHWRCDSQNDCSDN 3504
CAD + A T C P E C N C + RCD C +
Sbjct: 345 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 404
Query: 3505 SDEENCKPQTCTLKDFLCA-NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNG 3563
DE NC C ++F C+ NG C C+ C +GSDE+NC C F C N
Sbjct: 405 RDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-FFCQPGNFHCKNN 461
Query: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPT 3593
+C+ W CD +DC G DE++C PT
Sbjct: 462 RCVFESWVCDSQDDCGDGSDEENCPVIVPT 491
Score = 126 bits (317), Expect = 4e-28
Identities = 102/327 (31%), Positives = 138/327 (42%), Gaps = 62/327 (18%)
Query: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS----------CSPDYFQC-- 3443
C QF+C N KCIP +CN D+CGD DE C + + C+ + FQC
Sbjct: 166 CACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 3444 KTTK--HCISKLWVCDEDPDCADASDEANCDKKTCGPH--------------EFQCKNNN 3487
+ TK C+ + CD + DC D DE +CD TCG +F +N
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
Query: 3488 CI-----PDHWRC-----DSQNDCSDNSD--------EENCKPQTCTLKDFLC-ANGDCV 3528
C DH + D + D + D EEN L F A V
Sbjct: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
Query: 3529 SSR-----FWCDGDFDCADGSDER-NCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYG 3581
SS +C + A G + + C + C N C + +CDG+ C G
Sbjct: 345 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 404
Query: 3582 EDEKSCEPASPTCSSREYICASDG-CISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK 3640
DE +C C E+ C+ +G C S +CN + C +GSDE +C C+ F CK
Sbjct: 405 RDETNCT----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCK 459
Query: 3641 NKAHCIPIRWLCDGIHDCVDGSDEENC 3667
N C+ W+CD DC DGSDEENC
Sbjct: 460 NN-RCVFESWVCDSQDDCGDGSDEENC 485
Score = 126 bits (316), Expect = 6e-28
Identities = 104/374 (27%), Positives = 146/374 (39%), Gaps = 62/374 (16%)
Query: 2488 NCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYC 2547
N S +G R+ + N +C+ +F CGNG+CI C+ + C D SDE++
Sbjct: 146 NISRKGFRLAYFSGKSEEPNCACD---QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
Query: 2548 E-NRSCRRGFKPC-YNR-----------RCIPHGKLCDGENDCGDNSDELDCKVSTCATV 2594
E N F+PC YN+ C+P CDG DC D DE+DC V TC
Sbjct: 203 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQ- 261
Query: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVL 2654
+ GT N+ + FY G T I +L
Sbjct: 262 WLKYFYGT----------------------FNSPNYPDFYPPGSNCTWLIDTGDHRKVIL 299
Query: 2655 --PTWICDGSNDCGDYSDELKCPVQNKHKC--------EENYFSCPSGRCILNTWICDGQ 2704
+ DG+ GDY +N HK + S + C +
Sbjct: 300 RFTDFKLDGTG-YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADK 358
Query: 2705 KDCEDG-RDEFHCDSSCSWNQFACSAQ-KCISKHWICDGEDDCGDGLDESDSICGAITCA 2762
+ G + D C + C C ++ CDG C +G DE++ C
Sbjct: 359 VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN----CTMCQ 414
Query: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
+ F C + C PR C+ + CP+GSDE + C P N F C N C+ + +
Sbjct: 415 KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGN------FHCKNNRCVFESW 468
Query: 2823 VCDHDDDCGDGSDE 2836
VCD DDCGDGSDE
Sbjct: 469 VCDSQDDCGDGSDE 482
Score = 116 bits (291), Expect = 5e-25
Identities = 95/327 (29%), Positives = 134/327 (40%), Gaps = 61/327 (18%)
Query: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT----------CGPHEFQ 3482
E +C+ D F+C K CI + W C+ +C D+SDE C K+ C ++FQ
Sbjct: 163 EPNCACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
Query: 3483 C-----KNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC--TLKDFLCANGDCVSSRFWCD 3535
C K C+P+ +CD DC D DE +C TC LK F F+
Sbjct: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
Query: 3536 GDFDCA---DGSDERNC---ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
G +C D D R T D + I + + H+ + S P
Sbjct: 282 GS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
Query: 3590 ASPTCSS---REYICAS--------------DG-CISASLKCNGE-------------YD 3618
+ SS R + CA DG C+ + C G +
Sbjct: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 400
Query: 3619 CADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE 3678
C +G DE +C T C++++F C C P C+ + C +GSDE+NC C+
Sbjct: 401 CPNGRDETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGN 455
Query: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
F C N+ C WVCD +DDCGD SDE
Sbjct: 456 FHCKNNRCVFESWVCDSQDDCGDGSDE 482
Score = 107 bits (267), Expect = 3e-22
Identities = 91/313 (29%), Positives = 131/313 (41%), Gaps = 68/313 (21%)
Query: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC--EPASPT------CSSREYIC 3601
E +C+ DQFRC NG+CIP WKC+ ++C DE+ C E PT C+ ++ C
Sbjct: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 222
Query: 3602 ASD-----GCISASLKCNGEYDCADGSDEMDC-VTECKE------DQFRCKNKAHCIP-- 3647
S C+ SLKC+G DC D DE+DC V C + F N P
Sbjct: 223 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
Query: 3648 --IRWLCD-GIHDCV---------DGSD-----------EENCERGGNICRADE------ 3678
WL D G H V DG+ EEN + + A +
Sbjct: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
Query: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPD-MCVKFLCPSTRPHRCRNNRICLQSEQMCN 3737
+ ++ ++HF G N+ D C+ + P C N C +Q C+
Sbjct: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIP------CGGNWGCYTEQQRCD 396
Query: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACS-NKKCIPMDLQCDRLDDCGDGSDEQGC 3796
G C + DE +C C+K+EF CS N C P +C+ + C +GSDE+ C
Sbjct: 397 GYWHCPNGRDETNC--------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
Query: 3797 RIA-PTEYTCEDN 3808
P + C++N
Sbjct: 449 FFCQPGNFHCKNN 461
Score = 107 bits (266), Expect = 4e-22
Identities = 93/345 (26%), Positives = 137/345 (39%), Gaps = 86/345 (24%)
Query: 3472 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP----------QTCTLKDFL 3521
++ C +F+C N CIP+ W+C++ ++C D+SDEE C Q C F
Sbjct: 162 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
Query: 3522 CANG-----DCVSSRFWCDGDFDCADGSDERNCET-SCS---KDQFRCSNGQCIP----- 3567
C + C+ CDG+ DC D DE +C+ +C K + N P
Sbjct: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
Query: 3568 ---AKWKCDGHEDCK--------------YGEDEK--------------------SCEPA 3590
W D + K YG+ K S P
Sbjct: 282 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 341
Query: 3591 SPTCSS---REYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
+ SS R + CA ++A+ N Y DG C + C C
Sbjct: 342 TVVSSSGQIRVHFCADK--VNAARGFNATYQ-VDGF--------CLPWEIPCGGNWGCYT 390
Query: 3648 IRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN-NSLCKLHFWVCDGEDDCGDNSDEA 3706
+ CDG C +G DE NC +C+ +EF C+ N +C C+ ++ C + SDE
Sbjct: 391 EQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE- 445
Query: 3707 PDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
C F C H C+NNR C+ +C+ D+CGD SDE++C
Sbjct: 446 -KNC--FFCQPGNFH-CKNNR-CVFESWVCDSQDDCGDGSDEENC 485
Score = 105 bits (262), Expect = 1e-21
Identities = 90/337 (26%), Positives = 134/337 (39%), Gaps = 71/337 (21%)
Query: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE------SNQTCTA--RTCQVDQFSCGN 936
+C DQF+C N +CIP+ W C+ ++CG + DE +N A + C +QF C +
Sbjct: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 937 G-----RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRC----------I 981
C+P + CD DC D DE+ C+ PTC ++ +
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
Query: 982 SSKWHCDSDDD----------------------CGDGSDE----VGCVHSCFDNQFRC-- 1013
+ W D+ D DG +E + V + FD+
Sbjct: 284 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 343
Query: 1014 -SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWR 1072
SS I H+ D N F+ Q++ C E C + C + R
Sbjct: 344 VSSSGQIRVHFCADKVNAARGFNATYQVD---------GFCLPWEIPCGGNWGCYTEQQR 394
Query: 1073 CDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 1132
CDG C +G DE C +C K +F C G C ++ C+ C + SDE +C
Sbjct: 395 CDGYWHCPNGRDETNCT----MC-QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 448
Query: 1133 SFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
F C P C N+ C+ +C+ + DC DGSDE
Sbjct: 449 -FFCQPGNFHCKNNR--CVFESWVCDSQDDCGDGSDE 482
Score = 98.2 bits (243), Expect = 2e-19
Identities = 95/365 (26%), Positives = 129/365 (35%), Gaps = 85/365 (23%)
Query: 826 LDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHS 885
+ G + G++ C +FRC N CI WKC+ D+C D SDE+ C +
Sbjct: 147 ISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEA 204
Query: 886 ----------CPDDQFKCQNN-----RCIPKRWLCDGANDC---GSNEDESNQTC----- 922
C +QF+C + C+P+ CDG DC G D TC
Sbjct: 205 NPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLK 264
Query: 923 ----TARTCQVDQFSCGNGRCIPRAWLCDREDD----------------CGDQT---DEM 959
T + F C WL D D GD D +
Sbjct: 265 YFYGTFNSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 321
Query: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
LT F + + S C D + ++ + G C+
Sbjct: 322 EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ-----VDGFCL 376
Query: 1020 P------GHWAC-------DGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNC 1066
P G+W C DG C + DE NCT C EF C +G C
Sbjct: 377 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVC 426
Query: 1067 VPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQS 1126
P RC+ + C +GSDEK C F C RC+ ++WVCD DC D S
Sbjct: 427 YPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHC-KNNRCVFESWVCDSQDDCGDGS 480
Query: 1127 DEDDC 1131
DE++C
Sbjct: 481 DEENC 485
Score = 89.7 bits (221), Expect = 6e-17
Identities = 95/359 (26%), Positives = 128/359 (35%), Gaps = 83/359 (23%)
Query: 2620 SDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNK 2679
S+E NC C F RC + C+ W C+ ++CGD SDE C +
Sbjct: 161 SEEPNCA---CDQF-----------RCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEAN 205
Query: 2680 -------HKCEENYFSCPSG-----RCILNTWICDGQKDCEDGRDEFHCD---------- 2717
C N F C S C+ + CDG DC D DE CD
Sbjct: 206 PPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKY 265
Query: 2718 -----------------SSCSWNQFACSAQKCISKH--WICDGED-----DCGDGLDESD 2753
S+C+W +K I + + DG DGL+E+
Sbjct: 266 FYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENP 325
Query: 2754 SICGAITCAADM---FSCQGSRACVPRHWLCDGERDCPDGSDELSTAG-CAP-NNTCDEN 2808
+ A D + S + H+ D + G C P C N
Sbjct: 326 HKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 385
Query: 2809 AFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGD 2868
C +Q CD C +G DE+ C EEF C+ +C+
Sbjct: 386 WG------CYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQ 436
Query: 2869 FDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHI 2927
CP+ SDE C C F CKN RC+ +CD++DDCGDGSDE NC +
Sbjct: 437 NHCPNGSDEK----NCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 487
Score = 83.6 bits (205), Expect = 4e-15
Identities = 47/121 (38%), Positives = 60/121 (49%), Gaps = 16/121 (13%)
Query: 2558 PCY-NRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCA-DGTCIPRSARCNQNID 2615
PC N C + CDG C + DE +C + C EF C+ +G C PRS RCN
Sbjct: 381 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNH 438
Query: 2616 CADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCP 2675
C + SDEKNC +F+ C + CV +W+CD +DCGD SDE CP
Sbjct: 439 CPNGSDEKNCFFCQPGNFH-----------CKNNR-CVFESWVCDSQDDCGDGSDEENCP 486
Query: 2676 V 2676
V
Sbjct: 487 V 487
Score = 80.5 bits (197), Expect = 4e-14
Identities = 57/181 (31%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 784 LQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG----RVCACADNQLLDENGTTCTFNPGE 839
++IYD ++ + RV S L + RV CAD FN
Sbjct: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV-----NAARGFNATY 369
Query: 840 ALPHICKAGEFRCK-NRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC-QNNR 897
+ C E C N C + +CDG C +G DE NC C ++F C +N
Sbjct: 370 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNC--TMCQKEEFPCSRNGV 425
Query: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTD 957
C P+ C+ N C + DE N CQ F C N RC+ +W+CD +DDCGD +D
Sbjct: 426 CYPRSDRCNYQNHCPNGSDEKN----CFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSD 481
Query: 958 E 958
E
Sbjct: 482 E 482
Score = 75.5 bits (184), Expect = 1e-12
Identities = 71/286 (24%), Positives = 108/286 (37%), Gaps = 61/286 (21%)
Query: 2512 AYSEFECGNG-----ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIP 2566
AY++F+C + C+ L CDG C D DE + C+ +C + K Y P
Sbjct: 216 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSP 273
Query: 2567 H-------GKLCDGENDCGDNSDEL----DCKVSTCATVEF-RCADG------------- 2601
+ G C D GD+ + D K+ ++ + DG
Sbjct: 274 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
Query: 2602 --------TCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGF-----IRCNS 2648
T + S + + CAD + + + GF I C
Sbjct: 334 AFDSHAPLTVVSSSGQIRVHF-CAD--------KVNAARGFNATYQVDGFCLPWEIPCGG 384
Query: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCP-SGRCILNTWICDGQKDC 2707
C CDG C + DE C + C++ F C +G C + C+ Q C
Sbjct: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGVCYPRSDRCNYQNHC 439
Query: 2708 EDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
+G DE +C C F C +C+ + W+CD +DDCGDG DE +
Sbjct: 440 PNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEEN 484
Score = 70.5 bits (171), Expect = 4e-11
Identities = 51/157 (32%), Positives = 64/157 (40%), Gaps = 27/157 (17%)
Query: 3655 IHDCVDGSDEENCERGGN-------ICRADEFLCNNSL-CKLHFWVCDGEDDCGDNSDEA 3706
+H C +D+ N RG N C E C + C CDG C + DE
Sbjct: 352 VHFC---ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET 408
Query: 3707 P-DMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKD 3765
MC K P C N +C CN + C + SDE +C C+
Sbjct: 409 NCTMCQKEEFP------CSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--------CQPG 454
Query: 3766 EFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR-IAPT 3801
F C N +C+ CD DDCGDGSDE+ C I PT
Sbjct: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 491
Score = 68.6 bits (166), Expect = 1e-10
Identities = 40/113 (35%), Positives = 51/113 (45%), Gaps = 8/113 (7%)
Query: 2515 EFECG-NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC-YNRRCIPHGKLCD 2572
E CG N C Q CDG HC + DE C++ PC N C P C+
Sbjct: 379 EIPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCTMCQKEEFPCSRNGVCYPRSDRCN 434
Query: 2573 GENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
+N C + SDE +C C F C + C+ S C+ DC D SDE+NC
Sbjct: 435 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 67.4 bits (163), Expect = 3e-10
Identities = 37/127 (29%), Positives = 50/127 (39%), Gaps = 17/127 (13%)
Query: 2591 CATVEFRCADGT-CIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNST 2649
C E C C RC+ C + DE NC F C+
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEF-----------PCSRN 423
Query: 2650 SLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCED 2709
+C + C+ N C + SDE C C+ F C + RC+ +W+CD Q DC D
Sbjct: 424 GVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNRCVFESWVCDSQDDCGD 478
Query: 2710 GRDEFHC 2716
G DE +C
Sbjct: 479 GSDEENC 485
Score = 67.0 bits (162), Expect = 4e-10
Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 3315 SNCTASQ---FRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCA 3370
+NCT Q F C + C P +C+ + C +GSDE + C F CQPG F C C
Sbjct: 408 TNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN-C--FFCQPGNFHCKNNRCV 464
Query: 3371 LPAFICDGENDCGDNSDELNC 3391
+++CD ++DCGD SDE NC
Sbjct: 465 FESWVCDSQDDCGDGSDEENC 485
Score = 65.9 bits (159), Expect = 9e-10
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 20/105 (19%)
Query: 3346 SDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHV---------- 3395
S+EP+ C +F+CG G C A+ C+ ++CGD+SDE C
Sbjct: 161 SEEPN------CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 214
Query: 3396 CLSGQFKC----TKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
C QF+C TK C+P +L+C+G DC D DE DC +C
Sbjct: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
Score = 57.8 bits (138), Expect = 2e-07
Identities = 34/104 (32%), Positives = 45/104 (43%), Gaps = 22/104 (21%)
Query: 2503 CVTKNSSCNAY-----------------SEFECG-NGECIDYQLTCDGIPHCKDKSDEKL 2544
C T+ C+ Y EF C NG C C+ HC + SDEK
Sbjct: 388 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 447
Query: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKV 2588
+ C+ G C N RC+ +CD ++DCGD SDE +C V
Sbjct: 448 CFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 487
Score = 56.6 bits (135), Expect = 6e-07
Identities = 43/126 (34%), Positives = 53/126 (42%), Gaps = 36/126 (28%)
Query: 2885 KSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC-----------------HI 2927
KS E +C F C NG+CIP C+N D+CGD SDE C +
Sbjct: 160 KSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
Query: 2928 NECLSK--KVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFP-CSQQCI 2983
+CLS+ KV C LP S KC D C+D+ DE P C Q
Sbjct: 220 FQCLSRFTKVYTC------LPESLKC---------DGNIDCLDLGDEIDCDVPTCGQWLK 264
Query: 2984 NTYGTY 2989
YGT+
Sbjct: 265 YFYGTF 270
Score = 52.0 bits (123), Expect = 1e-05
Identities = 29/92 (31%), Positives = 38/92 (41%), Gaps = 11/92 (11%)
Query: 790 RKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGE 849
R + MC+ CS + P C ++ + C F C+ G
Sbjct: 405 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 455
Query: 850 FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
F CKN C+ W CD DDC DGSDE+ NC
Sbjct: 456 FHCKNNRCVFESWVCDSQDDCGDGSDEE--NC 485
Score = 50.4 bits (119), Expect = 4e-05
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY-CNQ 3820
C D+F C N KCIP +C+ +D+CGD SDE+ C T PC + + C
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA-AFQPCAYNQFQCLS 224
Query: 3821 IKTSVFCRCKPGFQRNMKNRQCEDLNE 3847
T V+ C P + N C DL +
Sbjct: 225 RFTKVY-TCLPESLKCDGNIDCLDLGD 250
Score = 47.4 bits (111), Expect = 3e-04
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK-- 1140
S+E C CD +F C G+CI +AW C+ +C D SDE+ C PP
Sbjct: 161 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKE-ANPPTAA 210
Query: 1141 --HPCANDTSVCLQ---------PEKL-CNGKKDCPDGSDE 1169
PCA + CL PE L C+G DC D DE
Sbjct: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE 251
Score = 46.2 bits (108), Expect = 7e-04
Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 9/109 (8%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
C P E C + C ++ CDG CP+ DE+ T ++ E C N + C
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGV-------CY 427
Query: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNCQYKCTMVRNSTRC 138
S CN CP+G DE CQ +C+ C ++ + + C
Sbjct: 428 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDC 476
Score = 44.3 bits (103), Expect = 0.003
Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP 70
C PG F C ++ CV +SW+CD DC D SDE + CP
Sbjct: 451 CQPGNFHCKNN-RCVFESWVCDSQDDCGDGSDE--ENCP 486
Score = 41.2 bits (95), Expect = 0.024
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 8/79 (10%)
Query: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
+C EF C + C +S C+ CP+ SDE C C + C N+C
Sbjct: 412 MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK--NC-----FFCQPGNFHC-KNNRC 463
Query: 91 VHLSQLCNGVLDCPDGYDE 109
V S +C+ DC DG DE
Sbjct: 464 VFESWVCDSQDDCGDGSDE 482
Score = 39.7 bits (91), Expect = 0.070
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 14/89 (15%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVE-------IKCPLNHIAC 84
C +F C + C+ ++W C+ +C D SDE + C +E C N C
Sbjct: 166 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 222
Query: 85 LG----TNKCVHLSQLCNGVLDCPDGYDE 109
L C+ S C+G +DC D DE
Sbjct: 223 LSRFTKVYTCLPESLKCDGNIDCLDLGDE 251
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 125 bits (314), Expect = 1e-27
Identities = 93/288 (32%), Positives = 119/288 (41%), Gaps = 35/288 (12%)
Query: 4172 LPNPCLDLACEF--LCLLNPSGA-TCVCPEGKYLINGTCNDDSLLDDSCKL--TCENGGR 4226
LP+PCL C C + P G C CP G +C D D C++ C +GG
Sbjct: 119 LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ--GRSCRSDV---DECRVGEPCRHGGT 173
Query: 4227 CILNEKGDLRCHCWPSYSGERCE---VNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPN 4283
C LN G RC C Y+G CE V + C+NGGTC S C+C GF G N
Sbjct: 174 C-LNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN 232
Query: 4284 CGKTVCE---DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CH---HYCVNSESC 4335
C V + C NGGTC V N C C PE+TG C V C + C N +C
Sbjct: 233 CEVNVDDCPGHRCLNGGTC-VDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTC 291
Query: 4336 TIGDDGSVECVCPTRYEGPKCE--VDKCVRC---HGGHCIINKDSEDIFCNCTNGKIASS 4390
G CVC + G C +D C HG C + +C C GK
Sbjct: 292 -FNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATC--HDRVASFYCACPMGKTGLL 348
Query: 4391 CQLCDGY----CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSS 4434
C L D C+ C +P +C C ++G C++ + S
Sbjct: 349 CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
Score = 114 bits (286), Expect = 2e-24
Identities = 90/277 (32%), Positives = 120/277 (43%), Gaps = 30/277 (10%)
Query: 4174 NPCLDLACEF-LCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLT-CENGGRCILNE 4231
+PC C +C P G CVC G +G SL D+C+ C GG C +
Sbjct: 697 HPCAHEPCSHGICYDAPGGFRCVCEPGW---SGPRCSQSLARDACESQPCRAGGTCSSDG 753
Query: 4232 KGDLRCHCWPSYSGERCEV-NHCS-NYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVC 4289
G C C P G +CE+ + C+ N C++GG C + P CSC G+ GP C + V
Sbjct: 754 MG-FHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD 812
Query: 4290 EDF----CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CH-HYCVNSESCTIGDDGS 4342
E C G C AG+ C C YTG C + C + C+N SC G GS
Sbjct: 813 ECAGPAPCGPHGICTNLAGSFS-CTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDG-VGS 870
Query: 4343 VECVCPTRYEGPKC--EVDKCVR--CHGGHCIINKDSEDIFCNCTNGKIASSCQ-----L 4393
C C + GP+C +VD+C+ C G C + S C C G C+
Sbjct: 871 FSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVAS--FTCTCPPGYGGFHCEQDLPDC 928
Query: 4394 CDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPA 4430
C+NGGTC N CLC ++G C+ A
Sbjct: 929 SPSSCFNGGTCV--DGVNSFSCLCRPGYTGAHCQHEA 963
Score = 109 bits (273), Expect = 6e-23
Identities = 81/268 (30%), Positives = 108/268 (40%), Gaps = 33/268 (12%)
Query: 4181 CEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCW 4240
C+ + + +C CP G G D SL D C +G RC + G C C
Sbjct: 93 CQSSVVAGTARFSCRCPRG---FRGP--DCSLPDPCLSSPCAHGARCSVGPDGRFLCSCP 147
Query: 4241 PSYSGERC--EVNHC--SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV---CEDFC 4293
P Y G C +V+ C C++GGTC+ + G C C G+TGP C C
Sbjct: 148 PGYQGRSCRSDVDECRVGEPCRHGGTCL-NTPGSFRCQCPAGYTGPLCENPAVPCAPSPC 206
Query: 4294 QNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--C-HHYCVNSESCTIGDDGSVECVCPTR 4350
+NGGTC + C C P + G C+ V C H C+N +C G + + C CP
Sbjct: 207 RNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN-TYNCQCPPE 265
Query: 4351 YEGPKC--EVDKCV----RCH-GGHCIINKDSEDIFCNCTNGKIASSC-----QLCDGYC 4398
+ G C +VD+C CH GG C C C NG SC C
Sbjct: 266 WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS--CVCVNGWTGESCSQNIDDCATAVC 323
Query: 4399 YNGGTCQLDPETNVPVCLCSTNWSGTQC 4426
++G TC C C +G C
Sbjct: 324 FHGATCH--DRVASFYCACPMGKTGLLC 349
Score = 106 bits (264), Expect = 6e-22
Identities = 78/231 (33%), Positives = 98/231 (42%), Gaps = 33/231 (14%)
Query: 4221 CENGGRCILNEKGDLRCHCWPSYSGERCEV-NHC-SNYCQNGGTCVPSVL---GRPTCSC 4275
C NGGRC + C C P + GERC++ + C S C G C SV+ R +C C
Sbjct: 49 CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108
Query: 4276 ALGFTGPNCG--KTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSE 4333
GF GP+C C +G C V + C C P Y G C+ V C E
Sbjct: 109 PRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDV--DECRVGE 166
Query: 4334 SCTIG-----DDGSVECVCPTRYEGPKCEVDKCVRC------HGGHCIINKDSEDIF--C 4380
C G GS C CP Y GP CE + V C +GG C + S D+ C
Sbjct: 167 PCRHGGTCLNTPGSFRCQCPAGYTGPLCE-NPAVPCAPSPCRNGGTC---RQSGDLTYDC 222
Query: 4381 NCTNGKIASSCQL----CDGY-CYNGGTCQLDPETNVPVCLCSTNWSGTQC 4426
C G +C++ C G+ C NGGTC N C C W+G C
Sbjct: 223 ACLPGFEGQNCEVNVDDCPGHRCLNGGTCV--DGVNTYNCQCPPEWTGQFC 271
Score = 103 bits (256), Expect = 5e-21
Identities = 87/334 (26%), Positives = 126/334 (37%), Gaps = 92/334 (27%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYS 4244
C+ S CVCPEG+ C + +D C++GG C G C C P Y+
Sbjct: 1061 CVDEDSSHYCVCPEGR--TGSHCEQE--VDPCLAQPCQHGGTC-RGYMGGYMCECLPGYN 1115
Query: 4245 GERCE--VNHCSNY-CQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNG----- 4296
G+ CE V+ C++ CQ+GG+C+ ++ R CSC G G C + ED C G
Sbjct: 1116 GDNCEDDVDECASQPCQHGGSCI-DLVARYLCSCPPGTLGVLC--EINEDDCGPGPPLDS 1172
Query: 4297 -------GTCIVTAGNQPYCHCQPEYTGDRCQYYV-------CHHYCVNSESCTIGDDGS 4342
GTC+ G C C P YTG RC+ + CH ++ C G
Sbjct: 1173 GPRCLHNGTCVDLVGGFR-CTCPPGYTGLRCEADINECRSGACH--AAHTRDCLQDPGGG 1229
Query: 4343 VECVCPTRYEGPKCE--VDKCVR--C-HGGHCI--------------------------I 4371
C+C + GP+C+ + C C HGG C +
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV 1289
Query: 4372 NKDSEDIFCN---------------CTNGKIASSCQLCDGY-------------CYNGGT 4403
+ ++ C C G SC+ G C +GG+
Sbjct: 1290 ARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGS 1349
Query: 4404 CQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSD 4437
C+ P C C+ W+G +CE PA S+
Sbjct: 1350 CRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSE 1383
Score = 90.5 bits (223), Expect = 3e-17
Identities = 88/336 (26%), Positives = 116/336 (34%), Gaps = 88/336 (26%)
Query: 4174 NPCLDLACEF--LCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNE 4231
+PCL C +C G C C E C +L+D + C+NGGRC+
Sbjct: 964 DPCLSRPCLHGGVCSAAHPGFRCTCLES--FTGPQCQ--TLVDWCSRQPCQNGGRCV--- 1016
Query: 4232 KGDLRCHCWPSYSGERCEVN-------------HCSNYCQNGGTCVPSVLGRPTCSCALG 4278
+ C C P +SG C++ CQ GG CV C C G
Sbjct: 1017 QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSH-YCVCPEG 1075
Query: 4279 FTGPNCGKTV---CEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV-------CHH- 4327
TG +C + V CQ+GGTC G C C P Y GD C+ V C H
Sbjct: 1076 RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGY-MCECLPGYNGDNCEDDVDECASQPCQHG 1134
Query: 4328 -YCVNSES--------------CTIGDD------------------------GSVECVCP 4348
C++ + C I +D G C CP
Sbjct: 1135 GSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCP 1194
Query: 4349 TRYEGPKCEVD----KCVRCHGGHC--IINKDSEDIFCNCTNGKIASSCQL----CDGY- 4397
Y G +CE D + CH H + C C G CQ C+
Sbjct: 1195 PGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQP 1254
Query: 4398 CYNGGTCQLDPETN---VPVCLCSTNWSGTQCERPA 4430
C +GG C+ P C C+ + G +CER A
Sbjct: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVA 1290
Score = 88.2 bits (217), Expect = 2e-16
Identities = 89/315 (28%), Positives = 113/315 (35%), Gaps = 72/315 (22%)
Query: 4173 PNPCL---------DLACEFLCLLNPSGATCV-----CPEGKYLINGTCNDDSLLD---- 4214
P+PC DL + CL G C CP + L GTC D
Sbjct: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262
Query: 4215 -------------DSCKL---TCENGGRCILNEKGDLRCHCWPSYSGERCEVN--HCSN- 4255
D C+L C NGG C N G C C ++GE C N C+
Sbjct: 263 PPEWTGQFCTEDVDECQLQPNACHNGGTCF-NTLGGHSCVCVNGWTGESCSQNIDDCATA 321
Query: 4256 YCQNGGTCVPSVLGRPTCSCALGFTGPNC--GKTVCEDFCQNGGTCIVTAGN-QPYCHCQ 4312
C +G TC V C+C +G TG C + C C N + C C
Sbjct: 322 VCFHGATCHDRVASF-YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCP 380
Query: 4313 PEYTGDRCQYYV---------CHHY--CVNSESCTIGDDGSVECVCPTRYEGPKCEVDKC 4361
P +TG C V C H CVN++ GS C C Y GP+CE D
Sbjct: 381 PGFTGGACDQDVDECSIGANPCEHLGRCVNTQ-------GSFLCQCGRGYTGPRCETD-V 432
Query: 4362 VRCHGGHCIINKDSED----IFCNCTNGKIASSCQL----CDGY-CYNGGTCQLDPETNV 4412
C G C D C C G + C++ C C NGG C+ N
Sbjct: 433 NECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK--DRVNG 490
Query: 4413 PVCLCSTNWSGTQCE 4427
C C + +SG+ C+
Sbjct: 491 FSCTCPSGFSGSTCQ 505
Score = 87.0 bits (214), Expect = 4e-16
Identities = 95/321 (29%), Positives = 124/321 (38%), Gaps = 88/321 (27%)
Query: 4174 NPCLDLAC--EFLCLLNPSGATCVCPEGKYLINGT-CNDDSLLDDSCKLTCENGGRCILN 4230
N CL C + CL TC+C G GT C D +D+ C NGG C
Sbjct: 433 NECLSGPCRNQATCLDRIGQFTCICMAG---FTGTYCEVD--IDECQSSPCVNGGVCKDR 487
Query: 4231 EKGDLRCHCWPSYSGERCE--VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKT 4287
G C C +SG C+ V+ C S C+NG CV G C CA GF G C +
Sbjct: 488 VNG-FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYE-CRCAEGFEGTLCDRN 545
Query: 4288 VCE---DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV-------CHH--YCVN---- 4331
V + D C +G C+ + C C P YTG RC+ V C H C++
Sbjct: 546 VDDCSPDPCHHG-RCVDGIASFS-CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603
Query: 4332 ----------------------SESCTIG--DDG--SVECVCPTRYEGPKC--EVDKCVR 4363
S CT G DG +CVC + GP C E+++C
Sbjct: 604 YLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECAS 663
Query: 4364 C---HGGHCIINKDSEDIF-CNCTNGKIASSC---------QLCD-GYCYN--GGTCQLD 4407
GG C+ D E+ F C C G + C + C G CY+ GG
Sbjct: 664 SPCGEGGSCV---DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGF---- 716
Query: 4408 PETNVPVCLCSTNWSGTQCER 4428
C+C WSG +C +
Sbjct: 717 ------RCVCEPGWSGPRCSQ 731
Score = 86.3 bits (212), Expect = 7e-16
Identities = 76/277 (27%), Positives = 100/277 (36%), Gaps = 42/277 (15%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYS 4244
C+ +G C+CP G + C S C + G C + G RC C P +S
Sbjct: 672 CVDGENGFRCLCPPGS--LPPLCLPPS---HPCAHEPCSHGICY-DAPGGFRCVCEPGWS 725
Query: 4245 GERCEVNHCSNYCQN-----GGTCVPSVLGRPTCSCALGFTGPNCG--KTVCEDFCQNGG 4297
G RC + + C++ GGTC +G C+C G G C + C++GG
Sbjct: 726 GPRCSQSLARDACESQPCRAGGTCSSDGMGFH-CTCPPGVQGRQCELLSPCTPNPCEHGG 784
Query: 4298 TCIVTAGNQPYCHCQPEYTGDRCQYYV--------C--HHYCVNSESCTIGDDGSVECVC 4347
C G P C C + G RCQ V C H C N GS C C
Sbjct: 785 RCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLA-------GSFSCTC 837
Query: 4348 PTRYEGPKCEVDKCVRCHGGHCIINKDSED----IFCNCTNGKIASSCQLCDGYCYNG-- 4401
Y GP C+ D C C+ +D C+C G C C +
Sbjct: 838 HGGYTGPSCDQD-INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC 896
Query: 4402 --GTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKS 4436
GTC C C + G CE+ P S S
Sbjct: 897 GPGTCT--DHVASFTCTCPPGYGGFHCEQDLPDCSPS 931
Score = 76.3 bits (186), Expect = 7e-13
Identities = 141/617 (22%), Positives = 203/617 (32%), Gaps = 147/617 (23%)
Query: 2466 SPCALLNGGCHDLCLLTPNGRVNCSCR----GDRILLEDNRCVTKNSSCNAYSEFECGNG 2521
SPCA NGG C P+ C C G+R LED C +G
Sbjct: 47 SPCA--NGG---RCTQLPSREAACLCPPGWVGERCQLED----------------PCHSG 85
Query: 2522 ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFK--------PCYNRRCIPHGKLCDG 2573
C G+ + C C RGF+ PC + C HG C
Sbjct: 86 PCAGR-----GVCQSSVVAGTARFSCR---CPRGFRGPDCSLPDPCLSSPCA-HGARCSV 136
Query: 2574 END------CGDNSDELDCK--VSTCATVEFRCADGTCI--PRSARCNQNIDCADASDEK 2623
D C C+ V C E GTC+ P S RC
Sbjct: 137 GPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ------------ 184
Query: 2624 NCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDC---GDYSDELKC-PVQNK 2679
C Y TG + C + ++ P+ C C GD + + C P
Sbjct: 185 ------CPAGY------TGPL-CENPAVPCAPS-PCRNGGTCRQSGDLTYDCACLPGFEG 230
Query: 2680 HKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACS--AQKCISKHW 2737
CE N CP RC+ C DG + ++C W C+ +C +
Sbjct: 231 QNCEVNVDDCPGHRCL-------NGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPN 283
Query: 2738 ICDGEDDCGDGLDESDSIC----GAITCAADMFSCQGSRACVPRHWLCDGER------DC 2787
C C + L +C +C+ ++ C V H +R C
Sbjct: 284 ACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCA---TAVCFHGATCHDRVASFYCAC 340
Query: 2788 PDGSDEL--STAGCAPNNTCDENAFMCHNKV------CIPKQFV---CDHD-DDCGDGSD 2835
P G L +N C E+A N V P F CD D D+C G++
Sbjct: 341 PMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400
Query: 2836 ESPQCGYRQCGTEEFSCADGRCLLNTQWQ----------CDGDFDCPDHSDEAPLNPKCK 2885
G F C GR + + C C D +
Sbjct: 401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAG 460
Query: 2886 SAEQSCNSSFFMCKNGRCIPSGGLCDNKDD-----CGDGSDERNCH--INECLSKKVSGC 2938
C C++ C+ +GG+C ++ + C G C ++EC S
Sbjct: 461 FTGTYCEVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNG 519
Query: 2939 SQDCQDLPVSYKCKCWPGFQLKDDGKTCV-DIDECSSGFPCSQ-QCINTYGTYKCLCTDG 2996
++ C D P Y+C+C GF+ G C ++D+CS PC +C++ ++ C C G
Sbjct: 520 AK-CVDQPDGYECRCAEGFE----GTLCDRNVDDCSPD-PCHHGRCVDGIASFSCACAPG 573
Query: 2997 YEIQPDNPNGCKSLSDE 3013
Y C+S DE
Sbjct: 574 Y-----TGTRCESQVDE 585
Score = 76.3 bits (186), Expect = 7e-13
Identities = 148/625 (23%), Positives = 219/625 (35%), Gaps = 152/625 (24%)
Query: 2463 CELSPCALLNGGCHDLCLLTPNGRVNCSC------RGDRILLEDNR----CVTKNSSCNA 2512
C SPCA +G C + P+GR CSC R R +++ R C + N
Sbjct: 123 CLSSPCA--HGA---RCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT 177
Query: 2513 YSEFECG------NGECIDYQLTCDGIP-----HCKDKSDEKLLY-------CENRSCRR 2554
F C C + + C P C+ D L Y E ++C
Sbjct: 178 PGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD--LTYDCACLPGFEGQNCEV 235
Query: 2555 GFKPCYNRRCIPHGKLCDGEND-------------CGDNSDELDCKVSTCATVEFRCADG 2601
C RC+ G DG N C ++ DE + + C G
Sbjct: 236 NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHN------GG 289
Query: 2602 TCIP-------------RSARCNQNI-DCADA--SDEKNCNNTDCTHFYKLGVKTTGFIR 2645
TC C+QNI DCA A C++ + + + TG +
Sbjct: 290 TCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLL- 348
Query: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSG-----------RC 2694
C+ CV SN C + + PV + C +CP G C
Sbjct: 349 CHLDDACV--------SNPCHEDAICDTNPVNGRAIC-----TCPPGFTGGACDQDVDEC 395
Query: 2695 ILNTWICDGQKDCEDGRDEFHCDSSCSWNQFAC--SAQKCISKHWICDGEDDCGDGLDES 2752
+ C+ C + + F C + C +C+S C + C D + +
Sbjct: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGP--CRNQATCLDRIGQF 453
Query: 2753 DSICGA----ITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDEN 2808
IC A C D+ CQ S CV +C +D +G +G + +TC +
Sbjct: 454 TCICMAGFTGTYCEVDIDECQSS-PCV-NGGVC---KDRVNGFSCTCPSGFS-GSTCQLD 507
Query: 2809 AFMCHNKVCIPKQFVCDHDDD----CGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ 2864
C + C D D C +G E C C GRC+
Sbjct: 508 VDECASTPCRNGAKCVDQPDGYECRCAEGF-EGTLCDRNVDDCSPDPCHHGRCV------ 560
Query: 2865 CDG--DFDC---PDHSDEAPLNPKCKSAEQSCNSSFFMCKN-GRCIP--SGGLCDNKDDC 2916
DG F C P ++ +C+S C S C++ G+C+ LC C
Sbjct: 561 -DGIASFSCACAPGYT-----GTRCESQVDECRSQ--PCRHGGKCLDLVDKYLC----RC 608
Query: 2917 GDGSDERNCHIN--ECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECS 2973
G+ NC +N +C S + C+D Y C C PGF G C V+I+EC+
Sbjct: 609 PSGTTGVNCEVNIDDCASNPCT--FGVCRDGINRYDCVCQPGF----TGPLCNVEINECA 662
Query: 2974 SGFPCSQ--QCINTYGTYKCLCTDG 2996
S PC + C++ ++CLC G
Sbjct: 663 SS-PCGEGGSCVDGENGFRCLCPPG 686
Score = 65.9 bits (159), Expect = 9e-10
Identities = 137/594 (23%), Positives = 186/594 (31%), Gaps = 201/594 (33%)
Query: 2459 DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFEC 2518
D + C+ SPC +NGG +C NG +C+C + C C + C
Sbjct: 469 DIDECQSSPC--VNGG---VCKDRVNG-FSCTCPSG---FSGSTCQLDVDEC---ASTPC 516
Query: 2519 GNG-ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDC 2577
NG +C+D DG C+ C GF+ G LCD D
Sbjct: 517 RNGAKCVDQP---DGY-ECR--------------CAEGFE----------GTLCDRNVD- 547
Query: 2578 GDNSDELDCKVSTCATVEFRCADG------TCIP--RSARCNQNIDCADASDEKNCNNTD 2629
DC C RC DG C P RC +D C +
Sbjct: 548 -------DCSPDPCH--HGRCVDGIASFSCACAPGYTGTRCESQVD--------ECRSQP 590
Query: 2630 CTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKH-KCEENYFS 2688
C H K L ++ ++C +CP CE N
Sbjct: 591 CRHGGKC--------------LDLVDKYLC-------------RCPSGTTGVNCEVNIDD 623
Query: 2689 CPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQ--KCISKHWICDGEDDCG 2746
C S C C DG + + C + C+ + +C S C C
Sbjct: 624 CASNPCTFGV--------CRDGINRYDCVCQPGFTGPLCNVEINECASSP--CGEGGSCV 673
Query: 2747 DGLDESDSIC--GAIT---------CAAD------MFSCQGSRACVPRHWLCDGERDCPD 2789
DG + +C G++ CA + + G CV C+ P
Sbjct: 674 DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCV-----CEPGWSGPR 728
Query: 2790 GSDELS-----TAGCAPNNTCDENAFMCHNKV--------------CIPKQFVCDHDDDC 2830
S L+ + C TC + H C P C+H C
Sbjct: 729 CSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP--CEHGGRC 786
Query: 2831 GDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ---CDGDFDCPDHSDEAPLNPK--CK 2885
+ P C SC G WQ C D D + + AP P C
Sbjct: 787 ESAPGQLPVC----------SCPQG-------WQGPRCQQDVD--ECAGPAPCGPHGICT 827
Query: 2886 SAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDL 2945
+ S + + C G PS CD D +C N CL+ CQD
Sbjct: 828 NLAGSFSCT---CHGGYTGPS---CDQ--------DINDCDPNPCLN------GGSCQDG 867
Query: 2946 PVSYKCKCWPGFQLKDDGKTCV-DIDECSSGFPCSQ-QCINTYGTYKCLCTDGY 2997
S+ C C PGF G C D+DEC S PC C + ++ C C GY
Sbjct: 868 VGSFSCSCLPGFA----GPRCARDVDECLSN-PCGPGTCTDHVASFTCTCPPGY 916
Score = 59.3 bits (142), Expect = 9e-08
Identities = 138/639 (21%), Positives = 211/639 (33%), Gaps = 123/639 (19%)
Query: 3298 CACP---TNFYLAADNRTCLSNCTASQFRCKTDK--------CIPFWW--KCDT-VDDCG 3343
CACP T D+ C+SN C T+ C P + CD VD+C
Sbjct: 338 CACPMGKTGLLCHLDD-ACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
Query: 3344 DGSDEPDDCPE-------FRCQPGRF----QCGTGLCALPAFICDGENDCGDNSDELNCD 3392
G++ + F CQ GR +C T + + C + C D + C
Sbjct: 397 IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCI 456
Query: 3393 THVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP------ENSCSPDYFQCKTT 3446
+G + +C + C C D + C ++C D +C +T
Sbjct: 457 CMAGFTGTYCEVDIDEC--QSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
Query: 3447 KHCISKLWVCDEDPD-----CADASDEANCDKKT--CGP---HEFQCKNN------NCIP 3490
C + C + PD CA+ + CD+ C P H +C + C P
Sbjct: 515 P-CRNGA-KCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAP 572
Query: 3491 DHW--RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVS--SRFWCDGDFDCADGSDE 3546
+ RC+SQ D C+ Q C G C+ ++ C C G+
Sbjct: 573 GYTGTRCESQVD--------ECRSQPCR------HGGKCLDLVDKYLCR----CPSGTTG 614
Query: 3547 RNCETSCSKDQFRCSNGQCIPAKWKCDG--HEDCKYGEDEKSCEPA--SPTCSSREYICA 3602
NCE + C++ C + DG DC C+P P C+ CA
Sbjct: 615 VNCEVNIDD----CASNPCTFGVCR-DGINRYDCV-------CQPGFTGPLCNVEINECA 662
Query: 3603 SDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGS 3662
S C C DG + C+ C +H GI G
Sbjct: 663 SSPCGEGG-------SCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG 715
Query: 3663 DEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCP-STRPH 3721
CE G + R + L ++ C+ + + + M CP +
Sbjct: 716 FRCVCEPGWSGPRCSQSLARDA--------CESQPCRAGGTCSSDGMGFHCTCPPGVQGR 767
Query: 3722 RCRNNRICLQSEQMCNGIDECGDNSDE-DHCGGKLTYKARPCKKDEFACSNKK-CIPMDL 3779
+C C + C C + C ++ C++D C+ C P +
Sbjct: 768 QCELLSPCTPNP--CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI 825
Query: 3780 QCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN-----PCGDDAYCNQIKTSVFCRCKPGFQ 3834
C L GS C T +C+ ++N PC + C S C C PGF
Sbjct: 826 -CTNLA----GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGF- 879
Query: 3835 RNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNF 3873
R D++ECL C + S+ C C +
Sbjct: 880 --AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY 916
Score = 59.3 bits (142), Expect = 9e-08
Identities = 132/565 (23%), Positives = 197/565 (34%), Gaps = 162/565 (28%)
Query: 2459 DTNSCELSPCALLNGG-CHDLCLLTPNGRVNCSC----RGDRILLEDNRCVTKNSSCNAY 2513
D N C+ +PC LNGG C D G +CSC G R + + C++
Sbjct: 849 DINDCDPNPC--LNGGSCQDGV-----GSFSCSCLPGFAGPRCARDVDECLSN------- 894
Query: 2514 SEFECGNGECIDY--QLTCDGIP-----HCKDKSDEKLLYCENRSCRRGFK-----PCYN 2561
CG G C D+ TC P HC ++ L C SC G ++
Sbjct: 895 ---PCGPGTCTDHVASFTCTCPPGYGGFHC----EQDLPDCSPSSCFNGGTCVDGVNSFS 947
Query: 2562 RRCIPH--GKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPR--SARCNQNIDCA 2617
C P G C E D + L V + A FRC TC+ +C +D
Sbjct: 948 CLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC---TCLESFTGPQCQTLVDW- 1003
Query: 2618 DASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTW---ICD-GSNDCGDYSDELK 2673
C+ C + + V+T + C P W +CD S C + + ++
Sbjct: 1004 -------CSRQPCQNGGRC-VQTGAYCLCP-------PGWSGRLCDIRSLPCREAAAQIG 1048
Query: 2674 CPVQNKHKCEENYFSCPSGRCIL--NTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQK 2731
V+ + C+ G+C+ ++ C C +GR HC+ C AQ
Sbjct: 1049 --VRLEQLCQAG------GQCVDEDSSHYCV----CPEGRTGSHCEQEVD----PCLAQP 1092
Query: 2732 CISKH----------WICD-----GEDDCGDGLDESDSICGAITCAADMFSCQGSRACVP 2776
C +H ++C+ D+C D +DE CA+ CQ +C+
Sbjct: 1093 C--QHGGTCRGYMGGYMCECLPGYNGDNCEDDVDE---------CASQ--PCQHGGSCID 1139
Query: 2777 --RHWLCDGERDCPDGS----DELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDC 2830
+LC CP G+ E++ C P D HN C+ D
Sbjct: 1140 LVARYLCS----CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV----------DL 1185
Query: 2831 GDGSDESPQCGYR--QCGTEEFSCADGRCLLNTQWQC----DGDFDCPDHSDEAPLNPKC 2884
G + GY +C + C G C C G F C H+ + P+C
Sbjct: 1186 VGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS--GPRC 1243
Query: 2885 KSAEQSCNSSFFMCKNG-RCIPSGGLCDNKDDCGDGSDERNCHINECL-----SKKVSGC 2938
++ C S C++G +C PS G G CH + + C
Sbjct: 1244 QTVLSPCESQ--PCQHGGQCRPSPG--------PGGGLTFTCHCAQPFWGPRCERVARSC 1293
Query: 2939 SQ-------DCQDLPVSYKCKCWPG 2956
+ CQ P +C C PG
Sbjct: 1294 RELQCPVGVPCQQTPRGPRCACPPG 1318
Score = 58.2 bits (139), Expect = 2e-07
Identities = 145/645 (22%), Positives = 202/645 (31%), Gaps = 149/645 (23%)
Query: 3284 CSH--LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFR----CKTDKCIPFWWKCD 3337
C H CL PG + C CP + + C S R C+ + + C
Sbjct: 168 CRHGGTCLNTPG-SFRCQCPAGYTGPLCENPAVP-CAPSPCRNGGTCRQSGDLTYDCACL 225
Query: 3338 TVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCL 3397
+ + DDCP RC G GT C D + NC
Sbjct: 226 PGFEGQNCEVNVDDCPGHRCLNG----GT---------------CVDGVNTYNCQCPPEW 266
Query: 3398 SGQFKCTKN-QKCIPVNLRCNGQDDCGDEEDERDC------PENSCSPDYFQCKTTKHCI 3450
+GQF CT++ +C C+ C + C SCS + C T
Sbjct: 267 TGQF-CTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATA---- 321
Query: 3451 SKLWVCDEDPDCAD--ASDEANCDKKTCG---PHEFQCKNNNCIPDHWRCDSQ------- 3498
VC C D AS C G + C +N C D CD+
Sbjct: 322 ----VCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDA-ICDTNPVNGRAI 376
Query: 3499 ---------NDCSDNSDEENCKPQTCTLKDFLCAN-GDCVSSR--FWCDGDFDCADGSDE 3546
C + DE C++ C + G CV+++ F C C G
Sbjct: 377 CTCPPGFTGGACDQDVDE-------CSIGANPCEHLGRCVNTQGSFLC----QCGRGYTG 425
Query: 3547 RNCETSCSKDQFRCSNGQCIPAKWKCDGHED----CKYGEDEKSCEPASPTCSSREYICA 3602
CET D C +G C D C G CE C S C
Sbjct: 426 PRCET----DVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSP--CV 479
Query: 3603 SDGCISASLKCNG-EYDCADGSDEMDC---VTECKEDQFRCKNKAHCI--PIRWLCDGIH 3656
+ G + NG C G C V EC C+N A C+ P + C
Sbjct: 480 NGGVCKD--RVNGFSCTCPSGFSGSTCQLDVDECASTP--CRNGAKCVDQPDGYEC---- 531
Query: 3657 DCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLC- 3715
C +G + C+R + C D C++ C D F C
Sbjct: 532 RCAEGFEGTLCDRNVDDCSPDP--CHHGRC--------------------VDGIASFSCA 569
Query: 3716 --PSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKK 3773
P RC +++ Q C +C D D+ C C+ + C++
Sbjct: 570 CAPGYTGTRC-ESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNP 628
Query: 3774 CIPMDLQCDRLDDCGDGSDEQGCRIAP--TEYTCEDNVN-----PCGDDAYCNQIKTSVF 3826
C C DG + C P T C +N PCG+ C +
Sbjct: 629 C--------TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFR 680
Query: 3827 CRCKPGFQRNMKNRQCEDLNECLVFGTCSHQ-CINVEGSYKCVCD 3870
C C PG + C + CSH C + G ++CVC+
Sbjct: 681 CLCPPGSLPPL----CLPPSHPCAHEPCSHGICYDAPGGFRCVCE 721
Score = 56.2 bits (134), Expect = 7e-07
Identities = 138/638 (21%), Positives = 194/638 (30%), Gaps = 157/638 (24%)
Query: 3296 HTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEF 3355
+ C CP+ T NC + C ++ C T C DG + D
Sbjct: 604 YLCRCPSG--------TTGVNCEVNIDDCASNPC--------TFGVCRDGINRYDCV--- 644
Query: 3356 RCQPGRFQ--CGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVN 3413
CQPG C + + C C D + C +C G C+P +
Sbjct: 645 -CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC---LCPPGSLP----PLCLPPS 696
Query: 3414 LRCNGQDDCGDEEDERDCPENSC--SPDYFQCKTTKHCISKLWVCD---EDPDCADASDE 3468
C + C C +P F+C VC+ P C+ +
Sbjct: 697 HPCAHEP----------CSHGICYDAPGGFRC-----------VCEPGWSGPRCSQSLAR 735
Query: 3469 ANCDKKTCGPHE--------FQCKNNNCIP--DHWRCDSQNDCSDNSDEEN--CKPQTCT 3516
C+ + C F C C P +C+ + C+ N E C+
Sbjct: 736 DACESQPCRAGGTCSSDGMGFHC---TCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQ 792
Query: 3517 LKDFLCANG----DCVSSRFWCDGDFDCAD--------GSDERNCE-----TSCSKDQFR 3559
L C G C C G C GS C SC +D
Sbjct: 793 LPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDIND 852
Query: 3560 CSNGQCIPAKWKCDGHEDCKYGEDEKSCEP--ASPTCSSREYICASDGCISASLKCNGEY 3617
C C+ DG G SC P A P C+ C S+ C G
Sbjct: 853 CDPNPCLNGGSCQDG-----VGSFSCSCLPGFAGPRCARDVDECLSNPC--------GPG 899
Query: 3618 DCADGSDEMDCVTECKEDQFRCKNKA-HCIPIRWLCDGIHDCVDGSDEENC----ERGGN 3672
C D C F C+ C P G CVDG + +C G
Sbjct: 900 TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT--CVDGVNSFSCLCRPGYTGA 957
Query: 3673 ICRADEFLCNNSLCKLHFWVCDG----------EDDCGDNSDEAPDMCVKFLCPSTRPHR 3722
C+ + C + C LH VC E G D C S +P
Sbjct: 958 HCQHEADPCLSRPC-LHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWC------SRQP-- 1008
Query: 3723 CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCD 3782
C+N C+Q+ C G ++ PC++ + + + ++ C
Sbjct: 1009 CQNGGRCVQTGAYCL--------CPPGWSGRLCDIRSLPCRE----AAAQIGVRLEQLCQ 1056
Query: 3783 RLDDCGDGSDEQGCRIAPTEYT---CEDNVNPC-----GDDAYCNQIKTSVFCRCKPGFQ 3834
C D C + P T CE V+PC C C C PG+
Sbjct: 1057 AGGQCVDEDSSHYC-VCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYN 1115
Query: 3835 RNMKNRQCE-DLNECLVFGTCSH--QCINVEGSYKCVC 3869
+ CE D++EC C H CI++ Y C C
Sbjct: 1116 GD----NCEDDVDEC-ASQPCQHGGSCIDLVARYLCSC 1148
Score = 55.8 bits (133), Expect = 9e-07
Identities = 126/538 (23%), Positives = 179/538 (33%), Gaps = 134/538 (24%)
Query: 795 DNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTF--NPGEALPHICKA-GEFR 851
D +C N +C PG AC D++ C+ NP E L G F
Sbjct: 363 DAICDTNPVNGRAICTCPPGFTGGAC------DQDVDECSIGANPCEHLGRCVNTQGSFL 416
Query: 852 CKNRHCIQARWKCDGD-DDCLDGSDEDSVNCFNHS---------------CPDDQFKCQN 895
C+ +C+ D ++CL G + C + C D +CQ+
Sbjct: 417 CQCGRGYTGP-RCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQS 475
Query: 896 NRCIPKRWLCDGAN--DCGSNEDESNQTCTARTCQVDQFSCGNG-RCIPR---------- 942
+ C+ D N C S TC + C NG +C+ +
Sbjct: 476 SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAE 535
Query: 943 ---AWLCDRE-DDC-------GDQTDEMAS-------------CEFPTCEPLTQFVCKSG 978
LCDR DDC G D +AS CE E +Q G
Sbjct: 536 GFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGG 595
Query: 979 RCIS--SKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWAC-DGDNDCGDFS 1035
+C+ K+ C C G+ V C + D C+S C G C DG N
Sbjct: 596 KCLDLVDKYLCR----CPSGTTGVNCEVNIDD----CASNPCTFG--VCRDGIN------ 639
Query: 1036 DEAQINCTKEEIHSPAGCNGNEFQCHPD-----GNCVPDLWRCDGEKD----CEDGSDEK 1086
+ +C + + CN +C G+CV DGE C GS
Sbjct: 640 ---RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCV------DGENGFRCLCPPGSLPP 690
Query: 1087 GCNGTIRLCDHKTKFSCWSTGRCINKAW----VCDGDID---CEDQSDEDDCDSFLCGPP 1139
C C H+ S G C + VC+ C D C+S C
Sbjct: 691 LCLPPSHPCAHEP----CSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
Query: 1140 KHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCD---ECSLNNGGCSNHCSVVPGRGIV 1196
C++D CP G +G C+ C+ N C PG+ V
Sbjct: 747 G-TCSSDGM---------GFHCTCPPGV-QGRQCELLSPCTPNPCEHGGRCESAPGQLPV 795
Query: 1197 CSCPEGLQLNKDNKTCEIVDYCSNHLKCSQ--VCEQHKHTVKCSCYEGWKLDVDGESC 1252
CSCP+G Q + + VD C+ C +C + C+C+ G+ G SC
Sbjct: 796 CSCPQGWQ---GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSC 846
Score = 54.3 bits (129), Expect = 3e-06
Identities = 133/626 (21%), Positives = 196/626 (31%), Gaps = 172/626 (27%)
Query: 2459 DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFEC 2518
+ N C SPC GG C+ NG C C + C+ + C + C
Sbjct: 657 EINECASSPCG--EGGS---CVDGENG-FRCLCPPGSL---PPLCLPPSHPC---AHEPC 704
Query: 2519 GNGECID----YQLTCD---GIPHCKDKSDEKLLYCENRSCRRGFKPC------YNRRCI 2565
+G C D ++ C+ P C CE++ CR G C ++ C
Sbjct: 705 SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDA--CESQPCRAG-GTCSSDGMGFHCTCP 761
Query: 2566 P--HGKLCDGENDCGDNSDELD--CKVSTCATVEFRCADGTCIPRSARCNQNIDCADASD 2621
P G+ C+ + C N E C+ + C G PR C Q++D
Sbjct: 762 PGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPR---CQQDVD------ 812
Query: 2622 EKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKH- 2680
+ G C +C +N G +S C +
Sbjct: 813 -----------------ECAGPAPCGPHGIC---------TNLAGSFS----CTCHGGYT 842
Query: 2681 --KCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACS--AQKCISKH 2736
C+++ C C+ C+DG F C + C+ +C+S
Sbjct: 843 GPSCDQDINDCDPNPCL-------NGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895
Query: 2737 WICDGEDDCGDGLDESDSIC----GAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSD 2792
G C D + C G C D+ C S C C DG +
Sbjct: 896 C---GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS--------CFNGGTCVDGVN 944
Query: 2793 ELSTAGCAPNNT---CDENAFMCHNKVCIPKQFVCDHDDDCGDG----------SDESPQ 2839
S C P T C A C ++ C+ H C S PQ
Sbjct: 945 SFSCL-CRPGYTGAHCQHEADPCLSRPCL-------HGGVCSAAHPGFRCTCLESFTGPQ 996
Query: 2840 CGYRQCGTEEFSCADGR--------CLLNTQWQ---CD-GDFDCPDHSDE--APLNPKCK 2885
C C +G CL W CD C + + + L C+
Sbjct: 997 CQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQ 1056
Query: 2886 SAEQSCN---SSFFMCKNGR-----------CIPS----GGLCDN-----KDDCGDGSDE 2922
+ Q + S + +C GR C+ GG C +C G +
Sbjct: 1057 AGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNG 1116
Query: 2923 RNCH--INECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGFPCS 2979
NC ++EC S+ C DL Y C C PG G C ++ D+C G P
Sbjct: 1117 DNCEDDVDECASQPCQH-GGSCIDLVARYLCSCPPGTL----GVLCEINEDDCGPGPPLD 1171
Query: 2980 Q--------QCINTYGTYKCLCTDGY 2997
C++ G ++C C GY
Sbjct: 1172 SGPRCLHNGTCVDLVGGFRCTCPPGY 1197
Score = 52.0 bits (123), Expect = 1e-05
Identities = 135/659 (20%), Positives = 215/659 (32%), Gaps = 131/659 (19%)
Query: 3297 TCACPTNFYLAADNRTC---LSNCTASQFRCKTDKCI--PFWWKCDTVDDCGDGSD---- 3347
+C CP+ F TC + C ++ R KC+ P ++C C +G +
Sbjct: 492 SCTCPSGF----SGSTCQLDVDECASTPCR-NGAKCVDQPDGYECR----CAEGFEGTLC 542
Query: 3348 --EPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTK 3405
DDC C GR C G+ + F C C C++ V C
Sbjct: 543 DRNVDDCSPDPCHHGR--CVDGIAS---FSCA----CAPGYTGTRCESQVDECRSQPCRH 593
Query: 3406 NQKCIPVN----LRC-NGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP 3460
KC+ + RC +G E + DC N C+ VC +
Sbjct: 594 GGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCT---------------FGVCRDGI 638
Query: 3461 DCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQND----CSDNSDEENCKPQTCT 3516
+ D + C +C ++ C D +N C S C P +
Sbjct: 639 NRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHP 698
Query: 3517 LKDFLCANGDCVSSRFWCDGDFDCA--DGSDERNCETSCSKDQFRCSNGQCIPAKWKC-- 3572
C++G C + G F C G C S ++D C + C A C
Sbjct: 699 CAHEPCSHGICYDA----PGGFRCVCEPGWSGPRCSQSLARDA--CESQPC-RAGGTCSS 751
Query: 3573 DG---HEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV 3629
DG H C G + CE SP C+ C G ++ C G
Sbjct: 752 DGMGFHCTCPPGVQGRQCELLSP-CTPNP--CEHGGRCESAPGQLPVCSCPQGWQG---- 804
Query: 3630 TECKEDQFRCKNKAHCIPIRWLCDGIHD-----CVDGSDEENCERGGNICRADEFLCNNS 3684
C++D C A C P +C + C G +C++ N C + L N
Sbjct: 805 PRCQQDVDECAGPAPCGP-HGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCL-NGG 862
Query: 3685 LCK--LHFWVCD------------GEDDCGDNS---DEAPDMCVKFLC---PSTRPHRCR 3724
C+ + + C D+C N D F C P C
Sbjct: 863 SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCE 922
Query: 3725 NNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRL 3784
+ NG C D + C + Y C+ + C ++ C+ +
Sbjct: 923 QDLPDCSPSSCFNG-GTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGV----- 976
Query: 3785 DDCGDGSDEQGCRIAP--TEYTCEDNVN-----PCGDDAYCNQIKTSVFCRCKPGFQ--- 3834
C C T C+ V+ PC + C ++T +C C PG+
Sbjct: 977 --CSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCLCPPGWSGRL 1032
Query: 3835 ---RNMKNRQCEDLNECLVFGTCSH--QCINVEGSYKCVCDQ-----NFQERNNTCIAE 3883
R++ R+ + C QC++ + S+ CVC + + ++ + C+A+
Sbjct: 1033 CDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQ 1091
Score = 47.4 bits (111), Expect = 3e-04
Identities = 44/153 (28%), Positives = 63/153 (41%), Gaps = 19/153 (12%)
Query: 45 CVSQSWLCDGDPDCPDDSDESLDTCP-----EEVEIKCPLNHIACLGTNKCVH--LSQLC 97
C+ S +G S E+ CP E +++ P + C G C ++
Sbjct: 43 CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTA 102
Query: 98 NGVLDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNST-RCYCEDGFEITEDGRSCK 154
CP G+ G C L C C + +C++ + C C G++ GRSC+
Sbjct: 103 RFSCRCPRGF-RGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ----GRSCR 156
Query: 155 -DQDECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
D DEC V C TC NT GS+ C C GY
Sbjct: 157 SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY 189
Score = 43.9 bits (102), Expect = 0.004
Identities = 24/68 (35%), Positives = 33/68 (48%), Gaps = 8/68 (11%)
Query: 3810 NPCGDDAYCNQIKTSVF-CRCKPGFQRNMKNRQCE-DLNECLVFGTCSH--QCINVEGSY 3865
+PC A C+ F C C PG+Q R C D++EC V C H C+N GS+
Sbjct: 126 SPCAHGARCSVGPDGRFLCSCPPGYQ----GRSCRSDVDECRVGEPCRHGGTCLNTPGSF 181
Query: 3866 KCVCDQNF 3873
+C C +
Sbjct: 182 RCQCPAGY 189
Score = 43.1 bits (100), Expect = 0.006
Identities = 111/528 (21%), Positives = 163/528 (30%), Gaps = 99/528 (18%)
Query: 787 YDPRKQQGD-NMCRVN----NGGCSTLCLAIPGGRVCAC--------ADNQLLD------ 827
Y R + D + CRV +GG CL PG C C +N +
Sbjct: 150 YQGRSCRSDVDECRVGEPCRHGGT---CLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPC 206
Query: 828 ENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCP 887
NG TC + C G + ++C C G G+ D VN +N CP
Sbjct: 207 RNGGTCRQSGDLTYDCACLPG---FEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP 263
Query: 888 DD---QFKCQN-NRCIPKRWLCDGANDCGSNEDESNQTC----TARTCQVDQFSCGNGRC 939
+ QF ++ + C + C C + + C T +C + C C
Sbjct: 264 PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVC 323
Query: 940 IPRA-------------------WLCDREDDC-GDQTDEMASCEFPTCEPLTQFVCKSGR 979
A LC +D C + E A C+ C G
Sbjct: 324 FHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPG- 382
Query: 980 CISSKWHCDSD-DDCGDGSDEVGCVHSCFDNQ--FRCSSGRCIPGHWACDGD-NDCGDFS 1035
+ CD D D+C G++ + C + Q F C GR G C+ D N+C
Sbjct: 383 --FTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGP-RCETDVNECLSGP 439
Query: 1036 DEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLC 1095
Q C C + C D+ C G + NG C
Sbjct: 440 CRNQATCLDRIGQFTCICMAGFTGTY----CEVDIDECQSSPCVNGGVCKDRVNGFSCTC 495
Query: 1096 DHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC------DSFLCGPPKHPCANDTSV 1149
S + C C DQ D +C + LC C+
Sbjct: 496 PSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS----- 550
Query: 1150 CLQPEKLCNGKKDCPDG-------SDEGYLCDECSLNNGGCSNHCSVVPGRGI------V 1196
P+ +G+ C DG GY C C + G+ + +
Sbjct: 551 ---PDPCHHGR--CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
Query: 1197 CSCPEGLQLNKDNKTCEI-VDYCSNHLKCSQVCEQHKHTVKCSCYEGW 1243
C CP G CE+ +D C+++ VC + C C G+
Sbjct: 606 CRCPSG----TTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGF 649
Score = 42.7 bits (99), Expect = 0.008
Identities = 44/174 (25%), Positives = 60/174 (34%), Gaps = 26/174 (14%)
Query: 30 QLCDPGEFLCHDHVTCVSQ--SWLCDGDPDCPDDSDESLDTCPE-EVEIKCPLNHIACLG 86
+LCD C + + LC C D+ CPE C CL
Sbjct: 1031 RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA 1090
Query: 87 TNKCVHLSQLCNGVL-----DCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTR--CY 139
C H C G + +C GY+ G +C++ + C CQ+ + + R C
Sbjct: 1091 -QPCQH-GGTCRGYMGGYMCECLPGYN-GDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
Query: 140 CEDGF-----EITED----GRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGY 184
C G EI ED G C GTC G + C+C GY
Sbjct: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV----GGFRCTCPPGY 1197
Score = 40.0 bits (92), Expect = 0.054
Identities = 38/131 (29%), Positives = 48/131 (36%), Gaps = 21/131 (16%)
Query: 56 PDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQE 115
P C D DE P C + I TN S C+G GY G C +
Sbjct: 805 PRCQQDVDECAGPAP------CGPHGIC---TNLAGSFSCTCHG------GYT-GPSCDQ 848
Query: 116 LLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTH 173
+++C C C S C C GF R +D DEC TC +
Sbjct: 849 DINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA---GPRCARDVDECLSNPCGPGTCTDHV 905
Query: 174 GSYTCSCVEGY 184
S+TC+C GY
Sbjct: 906 ASFTCTCPPGY 916
Score = 39.7 bits (91), Expect = 0.070
Identities = 39/149 (26%), Positives = 63/149 (42%), Gaps = 24/149 (16%)
Query: 51 LCDGDPDCPDDSDESLDTCPE-EVEIKCPLNHIACLGTNKCVHLSQLCN-------GVLD 102
+C C D CP + + C L+ AC+ +N C H +C+ +
Sbjct: 322 VCFHGATCHDRVASFYCACPMGKTGLLCHLDD-ACV-SNPC-HEDAICDTNPVNGRAICT 378
Query: 103 CPDGYDEGVHCQELLSNCQ--QLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQD 157
CP G+ G C + + C C++ +C + S C C G+ G C+ D +
Sbjct: 379 CPPGFTGGA-CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT----GPRCETDVN 433
Query: 158 ECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
EC + G C TC + G +TC C+ G+
Sbjct: 434 EC-LSGPCRNQATCLDRIGQFTCICMAGF 461
Score = 39.3 bits (90), Expect = 0.091
Identities = 125/588 (21%), Positives = 182/588 (30%), Gaps = 176/588 (29%)
Query: 3284 CSH--LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDD 3341
C H C APG+ C+CP + RC+ D VD+
Sbjct: 780 CEHGGRCESAPGQLPVCSCPQGW---------------QGPRCQQD-----------VDE 813
Query: 3342 CGDGSDEPDDC-PEFRCQ--PGRFQCGTGLCALPAFICDGENDCGDNSDELN-CDTHVCL 3397
C P C P C G F C C G ++N CD + CL
Sbjct: 814 CAG----PAPCGPHGICTNLAGSFSC----------TCHGGYTGPSCDQDINDCDPNPCL 859
Query: 3398 S--------GQFKCTKNQKCIP--VNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTK 3447
+ G F C+ C+P RC D +C N C P T
Sbjct: 860 NGGSCQDGVGSFSCS----CLPGFAGPRC--------ARDVDECLSNPCGPG----TCTD 903
Query: 3448 HCISKLWVCDE-------DPDCADASDEANCDKKTC--GPHEFQCKNNNCIPDHWRCDSQ 3498
H S C + D D S + + TC G + F C C P + Q
Sbjct: 904 HVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCL---CRPGYTGAHCQ 960
Query: 3499 NDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETS---CSK 3555
++ + C + C L +C+ F C C + C+T CS+
Sbjct: 961 HEA------DPCLSRPC-LHGGVCS---AAHPGFRC----TCLESFTGPQCQTLVDWCSR 1006
Query: 3556 DQFRCSN-GQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCN 3614
C N G+C+ C C G + C+ S C A+ + C
Sbjct: 1007 QP--CQNGGRCVQTGAYC----LCPPGWSGRLCDIRSLPCRE----AAAQIGVRLEQLCQ 1056
Query: 3615 GEYDCADGSDEMDCV-------TECKEDQFRCKNK----------------AHCIPIRWL 3651
C D CV + C+++ C + C+P +
Sbjct: 1057 AGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLP-GYN 1115
Query: 3652 CDGIHDCVDGSDEENCERGGN-ICRADEFLCN------NSLCKLHFWVCDGEDDCGDNSD 3704
D D VD + C+ GG+ I +LC+ LC+++ EDDCG
Sbjct: 1116 GDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEIN------EDDCGPGP- 1168
Query: 3705 EAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKK 3764
P RC +N C+ + G C Y C+
Sbjct: 1169 -----------PLDSGPRCLHNGTCV---DLVGGF----------RCTCPPGYTGLRCEA 1204
Query: 3765 DEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPC 3812
D C + C + D L D G G C + C+ ++PC
Sbjct: 1205 DINECRSGACHAAHTR-DCLQDPG-GGFRCLCHAGFSGPRCQTVLSPC 1250
Score = 38.9 bits (89), Expect = 0.12
Identities = 36/141 (25%), Positives = 53/141 (37%), Gaps = 15/141 (10%)
Query: 52 CDGDPDCPDDSDESLDTCPEEVE-IKCPLNHIACLGTNKCVHLSQLCNGVLD----CPDG 106
C C D D C E E C N C + C H + +G+ C G
Sbjct: 516 CRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDC-SPDPCHH-GRCVDGIASFSCACAPG 573
Query: 107 YDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQDECAVYG 163
Y G C+ + C+ C++ KC + + C C G G +C+ + D+CA
Sbjct: 574 YT-GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCASNP 628
Query: 164 TCSQTCRNTHGSYTCSCVEGY 184
CR+ Y C C G+
Sbjct: 629 CTFGVCRDGINRYDCVCQPGF 649
Score = 38.5 bits (88), Expect = 0.16
Identities = 53/232 (22%), Positives = 76/232 (32%), Gaps = 77/232 (33%)
Query: 26 DRDQQLCDP-GEFLCHDHV---TCVSQ----SWLCDGD-PDCPDDSDESLDTCPEEVE-- 74
D D+ L +P G C DHV TC + C+ D PDC S + TC + V
Sbjct: 887 DVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSF 946
Query: 75 ----------IKCPLNHIACLGTNKCVHLSQLCNGV-----LDCPDGYDEGVHCQELLSN 119
C CL + C+H +C+ C + + G CQ L+
Sbjct: 947 SCLCRPGYTGAHCQHEADPCL-SRPCLH-GGVCSAAHPGFRCTCLESFT-GPQCQTLVDW 1003
Query: 120 CQQLNCQYKCTMVRNSTRCYCEDGF------------------------EITEDGRSCKD 155
C + CQ V+ C C G+ ++ + G C D
Sbjct: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
Query: 156 QDECAVYGTCSQ-----------------------TCRNTHGSYTCSCVEGY 184
+D + Y C + TCR G Y C C+ GY
Sbjct: 1064 EDS-SHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Score = 37.7 bits (86), Expect = 0.27
Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 15/102 (14%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQYKCTMVR--NSTRCYCEDGFEITEDGRSC-KDQDEC 159
C G+ EG +C+ + +C C T V N+ C C + G+ C +D DEC
Sbjct: 224 CLPGF-EGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT----GQFCTEDVDEC 278
Query: 160 AVYGTCSQ---TCRNTHGSYTCSCVEGYLMQPDNRSCKAKIE 198
+ TC NT G ++C CV G+ SC I+
Sbjct: 279 QLQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCSQNID 316
Score = 36.6 bits (83), Expect = 0.59
Identities = 66/276 (23%), Positives = 85/276 (30%), Gaps = 80/276 (28%)
Query: 3658 CVDGSDEENCERGGNICR--ADEFLCNNSLCKLHFWV---CDGEDDCGDNSDEAPDMCVK 3712
C+DGS C GG + + E C LC WV C ED C +C
Sbjct: 43 CLDGSP---CANGGRCTQLPSREAAC---LCPPG-WVGERCQLEDPCHSGPCAGRGVCQS 95
Query: 3713 FLCPSTRPHRCRNNR-----------ICLQSEQMCNGIDECGDNSDEDH-CGGKLTYKAR 3760
+ T CR R CL S C C D C Y+ R
Sbjct: 96 SVVAGTARFSCRCPRGFRGPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGR 153
Query: 3761 PCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYT---CEDNV-----NPC 3812
C+ D C + C C + C+ P YT CE+ +PC
Sbjct: 154 SCRSDVDECR------VGEPCRHGGTCLNTPGSFRCQ-CPAGYTGPLCENPAVPCAPSPC 206
Query: 3813 GDDAYCNQIKTSVF-CRCKPGFQR-------------------------NMKNRQC---- 3842
+ C Q + C C PGF+ N N QC
Sbjct: 207 RNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEW 266
Query: 3843 ------EDLNECLVFGTCSHQ---CINVEGSYKCVC 3869
ED++EC + H C N G + CVC
Sbjct: 267 TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC 302
Score = 32.7 bits (73), Expect = 8.6
Identities = 39/155 (25%), Positives = 53/155 (34%), Gaps = 28/155 (18%)
Query: 1103 CWSTGRCIN-----KAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLC 1157
C + GRC A +C E ED C S PCA VC
Sbjct: 49 CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHS-------GPCAG-RGVCQSSVVAG 100
Query: 1158 NGKKDCPDGSDEGYLCDECSLNNGGCSN------HCSVVPGRGIVCSCPEGLQ---LNKD 1208
+ C G+ +CSL + S+ CSV P +CSCP G Q D
Sbjct: 101 TARFSCR--CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158
Query: 1209 NKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGW 1243
C + + C + C + +C C G+
Sbjct: 159 VDECRVGEPCRH----GGTCLNTPGSFRCQCPAGY 189
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 124 bits (310), Expect = 3e-27
Identities = 86/289 (29%), Positives = 120/289 (41%), Gaps = 29/289 (10%)
Query: 4168 KQLDLPNPCLDLACEF--LCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGG 4225
K +PC C CL + C CP + TC D C +GG
Sbjct: 136 KSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH--GPTCRQDVNECGQKPGLCRHGG 193
Query: 4226 RCILNEKGDLRCHCWPSYSGERCEVNH--CS-NYCQNGGTCVPSVLGRPTCSCALGFTGP 4282
C NE G RC C +++G CE + CS + CQNGGTC P+ C+C GFTG
Sbjct: 194 TCH-NEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQ 252
Query: 4283 NCGKTVCE---DFCQNGGTCIVTAGNQPYCHCQPEYTGDRC-----QYYVCHHYCVNSES 4334
NC + + + + C+NGG C V N C C PE+TG C + + + C N +
Sbjct: 253 NCEENIDDCPGNNCKNGGAC-VDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGT 311
Query: 4335 CTIGDDGSVECVCPTRYEGPKC--EVDKCVRC---HGGHCIINKDSEDIFCNCTNGKIAS 4389
C G CVC + G C +D C HG C + +C C +G+
Sbjct: 312 CH-NTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATC--HDRVASFYCECPHGRTGL 368
Query: 4390 SCQLCDGY----CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSS 4434
C L D C G C +P +C C + ++G C + + S
Sbjct: 369 LCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECS 417
Score = 116 bits (291), Expect = 5e-25
Identities = 91/295 (30%), Positives = 121/295 (41%), Gaps = 63/295 (21%)
Query: 4173 PNPCLDLACEFL-----------------CLLNPSGATCVCPEGKYLINGTCNDDSLLDD 4215
PNPCL C+ C L SG C+ P LD+
Sbjct: 60 PNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTP---------------LDN 104
Query: 4216 SCKLT-CENGGRCILNEKGDLRCHCWPSYSGERC-EVNHC-SNYCQNGGTCVPSVLGRPT 4272
+C C NGG C L + +C C P +SG+ C + + C SN C NGG C+P
Sbjct: 105 ACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASY-I 163
Query: 4273 CSCALGFTGPNCGKTVCE-----DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQ--YYVC 4325
C C F GP C + V E C++GGTC G+ C C+ +TG C+ Y C
Sbjct: 164 CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSY-RCVCRATHTGPNCERPYVPC 222
Query: 4326 H-HYCVNSESCTIGDDGSVECVCPTRYEGPKCE--VDKCV--RC-HGGHCIINKDSEDIF 4379
C N +C D + EC C + G CE +D C C +GG C+ ++ +
Sbjct: 223 SPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCR 282
Query: 4380 C-------NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPV-CLCSTNWSGTQC 4426
C CT CQL C NGGTC T+ C+C W+G C
Sbjct: 283 CPPEWTGQYCTED--VDECQLMPNACQNGGTCH---NTHGGYNCVCVNGWTGEDC 332
Score = 116 bits (291), Expect = 5e-25
Identities = 89/259 (34%), Positives = 119/259 (45%), Gaps = 34/259 (13%)
Query: 4190 SGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGG-RCILNEKGDLRCHCWPSYSGERC 4248
+G TC CPEG + + TC + +++ C +G R LN +C C P +SG C
Sbjct: 698 NGFTCRCPEGYH--DPTCLSE--VNECNSNPCVHGACRDSLN---GYKCDCDPGWSGTNC 750
Query: 4249 EVNH--C-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE---DFCQNGGTCIVT 4302
++N+ C SN C NGGTC G C+C GF+GPNC + E + C N GTCI
Sbjct: 751 DINNNECESNPCVNGGTCKDMTSGY-VCTCREGFSGPNCQTNINECASNPCLNQGTCIDD 809
Query: 4303 AGNQPYCHCQPEYTGDRCQYYVCH---HYCVNSESCTIGDD-GSVECVCPTRYEGPKCEV 4358
C+C YTG C+ + C N C +D S CVCPT ++G CEV
Sbjct: 810 VAGYK-CNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868
Query: 4359 D--KCVRC---HGGHCIINKDSEDIFCNCTNGKIASSCQL----C-DGYCYNGGTCQLDP 4408
D +CV HG C C+C G +C+ C C+NGG+C
Sbjct: 869 DINECVLSPCRHGASC--QNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSC--TD 924
Query: 4409 ETNVPVCLCSTNWSGTQCE 4427
N C C + GT CE
Sbjct: 925 GINTAFCDCLPGFRGTFCE 943
Score = 114 bits (286), Expect = 2e-24
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 39/279 (13%)
Query: 4172 LPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSL--LDDSCKLTCENGGRCIL 4229
+PN C + C G CVC +NG +D +DD C +G C
Sbjct: 302 MPNACQNGGT---CHNTHGGYNCVC------VNGWTGEDCSENIDDCASAACFHGATCH- 351
Query: 4230 NEKGDLRCHCWPSYSGERCEVNHC--SNYCQNGGTCVPS-VLGRPTCSCALGFTGPNCGK 4286
+ C C +G C +N SN C G C + V G+ C+C G+TGP C +
Sbjct: 352 DRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQ 411
Query: 4287 TVCE-----DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV---CHHYCVNSESCTIG 4338
V E + C++ G CI T G+ C C YTG RC+ V + C N +C +
Sbjct: 412 DVDECSLGANPCEHAGKCINTLGSFE-CQCLQGYTGPRCEIDVNECVSNPCQNDATC-LD 469
Query: 4339 DDGSVECVCPTRYEGPKCEV--DKCVRC---HGGHCIINKDSEDIFCNCTNGKIASSCQL 4393
G +C+C YEG CEV D+C H G C+ + C C G CQ
Sbjct: 470 QIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCL--DKINEFQCECPTGFTGHLCQY 527
Query: 4394 -----CDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
C NG C P T C+C+ ++GT CE
Sbjct: 528 DVDECASTPCKNGAKCLDGPNTYT--CVCTEGYTGTHCE 564
Score = 108 bits (270), Expect = 1e-22
Identities = 82/259 (31%), Positives = 108/259 (41%), Gaps = 35/259 (13%)
Query: 4193 TCVCPEGKYLINGTCNDDSLLDDSCKLT-CENGGRCILNEKGDLRCHCWPSYSGERCE-- 4249
+CVCP G TC D + C L+ C +G C N G RCHC YSG CE
Sbjct: 854 SCVCPTGWQ--GQTCEVDI---NECVLSPCRHGASC-QNTHGGYRCHCQAGYSGRNCETD 907
Query: 4250 VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE---DFCQNGGTCIVTAGN 4305
++ C N C NGG+C + C C GF G C + + E D C+NG C +
Sbjct: 908 IDDCRPNPCHNGGSCTDGI-NTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS 966
Query: 4306 QPYCHCQPEYTGDRCQYYV---CHHYCVNSESCTIGDDGSVECVCPTRYEGPKC-----E 4357
C C ++G C+ C N +C G + S C+CP + G C E
Sbjct: 967 YT-CTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGIN-SFTCLCPPGFTGSYCQHDVNE 1024
Query: 4358 VDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ----LCDGY-CYNGGTCQLDPETNV 4412
D HGG C C C G +CQ CD C NGG C +T+
Sbjct: 1025 CDSQPCLHGGTC--QDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCW---QTHT 1079
Query: 4413 PV-CLCSTNWSGTQCERPA 4430
C C + W+G C+ P+
Sbjct: 1080 QYRCECPSGWTGLYCDVPS 1098
Score = 106 bits (265), Expect = 5e-22
Identities = 90/287 (31%), Positives = 123/287 (42%), Gaps = 45/287 (15%)
Query: 4173 PNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEK 4232
P+PC + A C G +C C G + +N C+++ +D+ C+NGG C L+
Sbjct: 1151 PSPCQNGAT---CTDYLGGYSCKCVAGYHGVN--CSEE--IDECLSHPCQNGGTC-LDLP 1202
Query: 4233 GDLRCHCWPSYSGERCEVN--HC---------SNYCQNGGTCVPSVLGRPTCSCALGFTG 4281
+C C G CE+N C S C N GTCV V G +C+C GF G
Sbjct: 1203 NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQV-GGYSCTCPPGFVG 1261
Query: 4282 PNCGKTVCEDF---CQNGGT--CIVTAGNQPYCHCQPEYTGDRCQYYV--CHHY-CVNSE 4333
C V E C GT C+ N +C C+ +TG RC+ + C C N
Sbjct: 1262 ERCEGDVNECLSNPCDARGTQNCVQRV-NDFHCECRAGHTGRRCESVINGCKGKPCKNGG 1320
Query: 4334 SCTIGDDGS--VECVCPTRYEGPKCEVDK----CVRC-HGGHCIINKDSEDIFCNCTNGK 4386
+C + + + C CP +EG CE D +RC +GG CI S C C
Sbjct: 1321 TCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPT--CLCLGPF 1378
Query: 4387 IASSCQL-----CDGY--CYNGGTCQLDPETNVPVCLCSTNWSGTQC 4426
CQ C G CYN GTC+ E+ CLC ++G C
Sbjct: 1379 TGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLC 1425
Score = 106 bits (264), Expect = 6e-22
Identities = 88/288 (30%), Positives = 119/288 (41%), Gaps = 44/288 (15%)
Query: 4185 CLLNPS--GATCVCPEGKYLINGTC-----NDDSLLDDSCKLTCENGGRCILNEKGDLRC 4237
C+L+P GA+C G Y + N ++ +DD C NGG C + C
Sbjct: 873 CVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCT-DGINTAFC 931
Query: 4238 HCWPSYSGERCE--VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV---CED 4291
C P + G CE +N C S+ C+NG C V TC+C GF+G +C E
Sbjct: 932 DCLPGFRGTFCEEDINECASDPCRNGANCTDCV-DSYTCTCPAGFSGIHCENNTPDCTES 990
Query: 4292 FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CHHY-CVNSESCTIGDDGSVECVCP 4348
C NGGTC V N C C P +TG CQ+ V C C++ +C G GS C CP
Sbjct: 991 SCFNGGTC-VDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC-GSYRCTCP 1048
Query: 4349 TRYEGPKCE-----VDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQL----CD---- 4395
Y GP C+ D +GG C + C C +G C + C+
Sbjct: 1049 QGYTGPNCQNLVHWCDSSPCKNGGKCW--QTHTQYRCECPSGWTGLYCDVPSVSCEVAAQ 1106
Query: 4396 -------GYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKS 4436
C +GG C N C C ++G+ CE + S S
Sbjct: 1107 RQGVDVARLCQHGGLCV--DAGNTHHCRCQAGYTGSYCEDLVDECSPS 1152
Score = 103 bits (257), Expect = 4e-21
Identities = 89/305 (29%), Positives = 122/305 (40%), Gaps = 59/305 (19%)
Query: 4173 PNPCLDLACE-----FLCLLNPS--------------------GATCVCPEGKYL---IN 4204
P+PC +C+ F CL P G TC + YL +
Sbjct: 572 PDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLK 631
Query: 4205 GTC--NDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVN--HCS-NYCQN 4259
GT N + LDD C++G L++ C C P Y+G C +N C+ N C N
Sbjct: 632 GTTGPNCEINLDDCASSPCDSG--TCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHN 689
Query: 4260 GGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAG----NQPYCHCQPEY 4315
GGTC + G TC C G+ P C V E C N C+ A N C C P +
Sbjct: 690 GGTCEDGINGF-TCRCPEGYHDPTCLSEVNE--C-NSNPCVHGACRDSLNGYKCDCDPGW 745
Query: 4316 TGDRCQYY--VCH-HYCVNSESCTIGDDGSVECVCPTRYEGPKCE--VDKCVR---CHGG 4367
+G C C + CVN +C G V C C + GP C+ +++C + G
Sbjct: 746 SGTNCDINNNECESNPCVNGGTCKDMTSGYV-CTCREGFSGPNCQTNINECASNPCLNQG 804
Query: 4368 HCIINKDSEDIFCNCTNGKIASSCQL-----CDGYCYNGGTCQLDPETNVPVCLCSTNWS 4422
CI D CNC ++C++ C NGG C+ + C+C T W
Sbjct: 805 TCI--DDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQ 862
Query: 4423 GTQCE 4427
G CE
Sbjct: 863 GQTCE 867
Score = 101 bits (252), Expect = 1e-20
Identities = 82/278 (29%), Positives = 120/278 (43%), Gaps = 42/278 (15%)
Query: 4184 LCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSY 4243
LC+ + C C G C D L+D+ C+NG C + G C C Y
Sbjct: 1121 LCVDAGNTHHCRCQAG--YTGSYCED--LVDECSPSPCQNGATCT-DYLGGYSCKCVAGY 1175
Query: 4244 SGERC--EVNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE---------- 4290
G C E++ C S+ CQNGGTC+ + CSC G G +C V +
Sbjct: 1176 HGVNCSEEIDECLSHPCQNGGTCL-DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSR 1234
Query: 4291 -DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVE----- 4344
C N GTC+ G C C P + G+RC+ V + C+++ G V+
Sbjct: 1235 SPKCFNNGTCVDQVGGYS-CTCPPGFVGERCEGDV--NECLSNPCDARGTQNCVQRVNDF 1291
Query: 4345 -CVCPTRYEGPKCE--VDKCVR--C-HGGHCII-NKDSEDIFCNCTNGKIASSCQ----L 4393
C C + G +CE ++ C C +GG C + + + C C G ++C+
Sbjct: 1292 HCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDART 1351
Query: 4394 CDGY-CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPA 4430
C C NGGTC P + P CLC ++G +C+ PA
Sbjct: 1352 CGSLRCLNGGTCISGPRS--PTCLCLGPFTGPECQFPA 1387
Score = 99.8 bits (247), Expect = 6e-20
Identities = 85/281 (30%), Positives = 120/281 (42%), Gaps = 51/281 (18%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYS 4244
C+ + TC+CP G C D +++ C +GG C + G RC C Y+
Sbjct: 998 CVDGINSFTCLCPPG--FTGSYCQHD--VNECDSQPCLHGGTC-QDGCGSYRCTCPQGYT 1052
Query: 4245 GERCE--VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCG--KTVCE--------- 4290
G C+ V+ C S+ C+NGG C + + C C G+TG C CE
Sbjct: 1053 GPNCQNLVHWCDSSPCKNGGKCWQTHT-QYRCECPSGWTGLYCDVPSVSCEVAAQRQGVD 1111
Query: 4291 --DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV---CHHYCVNSESCTIGDDGSVEC 4345
CQ+GG C V AGN +C CQ YTG C+ V C N +CT G C
Sbjct: 1112 VARLCQHGGLC-VDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCT-DYLGGYSC 1169
Query: 4346 VCPTRYEGPKC--EVDKCVR--C-HGGHCIINKDSEDIF-CNCTNGKIASSCQL----CD 4395
C Y G C E+D+C+ C +GG C+ D + + C+C G C++ C+
Sbjct: 1170 KCVAGYHGVNCSEEIDECLSHPCQNGGTCL---DLPNTYKCSCPRGTQGVHCEINVDDCN 1226
Query: 4396 ---------GYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
C+N GTC + C C + G +CE
Sbjct: 1227 PPVDPVSRSPKCFNNGTCV--DQVGGYSCTCPPGFVGERCE 1265
Score = 98.6 bits (244), Expect = 1e-19
Identities = 72/230 (31%), Positives = 93/230 (40%), Gaps = 47/230 (20%)
Query: 4220 TCENGGRCILNEKGDLRCHCWPSYSGERCE-VNHC-SNYCQNGGTCVPSVLGRP-----T 4272
TC NGG+C G C C ++ G RC+ N C S C+N GTC V+ R
Sbjct: 30 TCLNGGKCEA-ANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTC--HVVDRRGVADYA 86
Query: 4273 CSCALGFTGPNC----GKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYY--VCH 4326
CSCALGF+GP C + C+NGGTC + + C C P ++G CQ
Sbjct: 87 CSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCAS 146
Query: 4327 HYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGK 4386
+ C N C + + S C CP + GP C D
Sbjct: 147 NPCANGGQC-LPFEASYICHCPPSFHGPTCRQD--------------------------- 178
Query: 4387 IASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKS 4436
+ C G C +GGTC E C+C +G CERP S S
Sbjct: 179 -VNECGQKPGLCRHGGTCH--NEVGSYRCVCRATHTGPNCERPYVPCSPS 225
Score = 91.7 bits (226), Expect = 2e-17
Identities = 84/307 (27%), Positives = 113/307 (36%), Gaps = 68/307 (22%)
Query: 4174 NPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKG 4233
NPC C+ C C +G C D +++ C+N C L++ G
Sbjct: 421 NPCEHAG---KCINTLGSFECQCLQG--YTGPRCEID--VNECVSNPCQNDATC-LDQIG 472
Query: 4234 DLRCHCWPSYSGERCEVNH---CSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE 4290
+ +C C P Y G CEVN S+ C + G C+ + C C GFTG C V E
Sbjct: 473 EFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI-NEFQCECPTGFTGHLCQYDVDE 531
Query: 4291 ---DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV-------CH-------------- 4326
C+NG C+ N C C YTG C+ + CH
Sbjct: 532 CASTPCKNGAKCL-DGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCL 590
Query: 4327 -------HYC------VNSESCTIGD-----DGSVECVCPTRYEGPKCEV--DKCVR--C 4364
H+C +S+ C G D + C C GP CE+ D C C
Sbjct: 591 CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPC 650
Query: 4365 HGGHCIINKDSEDIFCNCTNGKIASSCQL----CDGY-CYNGGTCQLDPETNVPVCLCST 4419
G C+ D + C C G S C + C G C+NGGTC + N C C
Sbjct: 651 DSGTCLDKIDGYE--CACEPGYTGSMCNINIDECAGNPCHNGGTC--EDGINGFTCRCPE 706
Query: 4420 NWSGTQC 4426
+ C
Sbjct: 707 GYHDPTC 713
Score = 86.7 bits (213), Expect = 5e-16
Identities = 78/268 (29%), Positives = 108/268 (40%), Gaps = 30/268 (11%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCE-NGGRCILNEKGDLRCHCWPSY 4243
C+ G +C CP G + C D +++ C+ G + + D C C +
Sbjct: 1244 CVDQVGGYSCTCPPG--FVGERCEGD--VNECLSNPCDARGTQNCVQRVNDFHCECRAGH 1299
Query: 4244 SGERCE--VNHCSNY-CQNGGTC-VPSVLGRP-TCSCALGFTGPNC---GKTVCEDFCQN 4295
+G RCE +N C C+NGGTC V S R C C GF G C +T C N
Sbjct: 1300 TGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLN 1359
Query: 4296 GGTCIVTAGNQPYCHCQPEYTGDRCQYYVCH-----HYCVNSESCT-IGDDGSVECVCPT 4349
GGTCI + P C C +TG CQ+ + C N +C + C+CP
Sbjct: 1360 GGTCI-SGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPA 1418
Query: 4350 RYEGPKCEV-DKCVRCHGGHCI----INKDSEDIFCNCTNGKIASSCQLCDGYC-YNGGT 4403
++ G C + D G I I + E C G S Q + C ++GG
Sbjct: 1419 KFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGD 1478
Query: 4404 CQL---DPETNVPVCL-CSTNWSGTQCE 4427
C L DP N L C +S C+
Sbjct: 1479 CSLNFNDPWKNCTQSLQCWKYFSDGHCD 1506
Score = 79.7 bits (195), Expect = 6e-14
Identities = 139/617 (22%), Positives = 204/617 (33%), Gaps = 122/617 (19%)
Query: 3313 CLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRC--QPG----RFQCGT 3366
CL T + ++C+ + C + + D EF+C PG + T
Sbjct: 440 CLQGYTGPRCEIDVNECVS--------NPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT 491
Query: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEE 3426
CA + +G C D +E C+ +G +C + C C D
Sbjct: 492 DECASSPCLHNGR--CLDKINEFQCECPTGFTGHLCQYDVDEC--ASTPCKNGAKCLDGP 547
Query: 3427 DERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP----DCADASDEANCDKKTCGP---- 3478
+ C C+ Y T HC + CD DP C D C C P
Sbjct: 548 NTYTCV---CTEGY----TGTHCEVDIDECDPDPCHYGSCKDGVATFTC---LCRPGYTG 597
Query: 3479 HEFQCKNNNCIPDHWR----CDSQND-----CSDNSDEENCKPQTCTLKDFLCANGDCVS 3529
H + N C R C +++ C + NC+ C +G C+
Sbjct: 598 HHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLD 657
Query: 3530 SRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
DG ++CA CE + + +C A C C+ G + +C
Sbjct: 658 K---IDG-YECA-------CEPGYTGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCRC 704
Query: 3590 AS----PTCSSREYICASDGCISASLK--CNG-EYDCADGSDEMDCV---TECKEDQFRC 3639
PTC S C S+ C+ + + NG + DC G +C EC+ + C
Sbjct: 705 PEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNP--C 762
Query: 3640 KNKAHCIPIR--WLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGED 3697
N C + ++C C +G NC+ N C ++ L N C D
Sbjct: 763 VNGGTCKDMTSGYVCT----CREGFSGPNCQTNINECASNPCL-NQGTCI---------D 808
Query: 3698 D-----CGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCG 3752
D C C L P P CRN C QSE + C
Sbjct: 809 DVAGYKCNCLLPYTGATCEVVLAPCA-PSPCRNGGECRQSEDY-----------ESFSCV 856
Query: 3753 GKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV--- 3809
++ + C+ D C C C G C+ + CE ++
Sbjct: 857 CPTGWQGQTCEVDINECVLSPC-RHGASCQNTH----GGYRCHCQAGYSGRNCETDIDDC 911
Query: 3810 --NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSH--QCINVEGSY 3865
NPC + C + FC C PGF+ ED+NEC C + C + SY
Sbjct: 912 RPNPCHNGGSCTDGINTAFCDCLPGFRGTFCE---EDINEC-ASDPCRNGANCTDCVDSY 967
Query: 3866 KCVCDQNFQE---RNNT 3879
C C F NNT
Sbjct: 968 TCTCPAGFSGIHCENNT 984
Score = 75.5 bits (184), Expect = 1e-12
Identities = 144/638 (22%), Positives = 208/638 (32%), Gaps = 156/638 (24%)
Query: 2445 DIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTP-NGRVNCSCRG---------- 2493
+ PH G++ ND +C +PC N G + C P NG+ C+C
Sbjct: 360 ECPHGRTGLLCHLND--ACISNPC---NEGSN--CDTNPVNGKAICTCPSGYTGPACSQD 412
Query: 2494 -DRILLEDNRCVTKNSSCNAYSEFEC-------------GNGECIDYQLTCDGIPHCKDK 2539
D L N C N FEC EC+ C C D+
Sbjct: 413 VDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNP--CQNDATCLDQ 470
Query: 2540 SDEKLLYC----ENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVE 2595
E C E C C + C+ +G+ C D +E C+ T T
Sbjct: 471 IGEFQCICMPGYEGVHCEVNTDECASSPCLHNGR-------CLDKINEFQCECPTGFTGH 523
Query: 2596 FRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLP 2655
C S C C D + C CT Y TG + C +
Sbjct: 524 L-CQYDVDECASTPCKNGAKCLDGPNTYTCV---CTEGY------TG-------THCEVD 566
Query: 2656 TWICDGS----NDCGDYSDELKC---PVQNKHKCEENYFSCPSGRCILNTWICDGQKDCE 2708
CD C D C P H CE N C S C C+
Sbjct: 567 IDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGG-------TCQ 619
Query: 2709 DGRDEFHC-------DSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITC 2761
D + + C +C N C++ C D G LD+ D
Sbjct: 620 DRDNAYLCFCLKGTTGPNCEINLDDCASSPC-----------DSGTCLDKIDG------- 661
Query: 2762 AADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDE--NAFMC------H 2813
+ C AC P + G C DE + C TC++ N F C H
Sbjct: 662 ----YEC----ACEPGY---TGSM-CNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYH 709
Query: 2814 NKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ---CDGDFD 2870
+ C+ + C+ + C G+ GY+ C + + N + + C
Sbjct: 710 DPTCLSEVNECN-SNPCVHGACRDSLNGYK-CDCDPGWSGTNCDINNNECESNPCVNGGT 767
Query: 2871 CPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDN----KDDCGDGSDERNCH 2926
C D + + + +C ++ C + C+ G D+ K +C C
Sbjct: 768 CKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCE 827
Query: 2927 I-------NECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGFPC 2978
+ + C + S+D + S+ C C G+Q G+TC VDI+EC PC
Sbjct: 828 VVLAPCAPSPCRNGGECRQSEDYE----SFSCVCPTGWQ----GQTCEVDINECVLS-PC 878
Query: 2979 SQ--QCINTYGTYKCLCTDGY-------EIQPDNPNGC 3007
C NT+G Y+C C GY +I PN C
Sbjct: 879 RHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPC 916
Score = 74.7 bits (182), Expect = 2e-12
Identities = 153/682 (22%), Positives = 225/682 (32%), Gaps = 135/682 (19%)
Query: 3269 QPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDK 3328
+P + H C N CS G TC N YL CL T D
Sbjct: 592 RPGYTGHHCETNINECSSQPCRHGG---TCQDRDNAYLCF----CLKGTTGPNCEINLDD 644
Query: 3329 CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRF--QCGTGLCALPAFICDGENDCGDNS 3386
C + D G D+ D E C+PG C + C C D
Sbjct: 645 C------ASSPCDSGTCLDKIDGY-ECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGI 697
Query: 3387 DELNC------DTHVCLSGQFKCTKNQKCIPVNLR--CNGQD-DCGDEEDERDCPENSCS 3437
+ C CLS +C N C+ R NG DC +C N+
Sbjct: 698 NGFTCRCPEGYHDPTCLSEVNECNSNP-CVHGACRDSLNGYKCDCDPGWSGTNCDINNNE 756
Query: 3438 PDYFQCKTTKHC--ISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRC 3495
+ C C ++ +VC C + NC +C +N C+
Sbjct: 757 CESNPCVNGGTCKDMTSGYVCT----CREGFSGPNCQTNIN-----ECASNPCL------ 801
Query: 3496 DSQNDCSDNSDEENCK------PQTCTLKDFLCA------NGDCVSSRFWCDGDFDCADG 3543
+Q C D+ C TC + CA G+C S + C G
Sbjct: 802 -NQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860
Query: 3544 SDERNCETSCSKDQFR-CSNG---QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREY 3599
+ CE ++ C +G Q ++C C+ G ++CE C R
Sbjct: 861 WQGQTCEVDINECVLSPCRHGASCQNTHGGYRCH----CQAGYSGRNCETDIDDC--RPN 914
Query: 3600 ICASDGCISASLKCNGEYDCADGSDEMDC---VTECKEDQFRCKNKAHCIPI--RWLC-- 3652
C + G + + DC G C + EC D C+N A+C + C
Sbjct: 915 PCHNGGSCTDGIN-TAFCDCLPGFRGTFCEEDINECASDP--CRNGANCTDCVDSYTCTC 971
Query: 3653 ----DGIH-----------------DCVDGSDEENC----ERGGNICRADEFLCNNSLCK 3687
GIH CVDG + C G+ C+ D C++ C
Sbjct: 972 PAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPC- 1030
Query: 3688 LHFWVCDGEDDCGDNSDEAPDMCVKFLCPS--TRPHRCRNNRICLQSEQMCNGIDECGDN 3745
LH C +D CG + CP T P+ C+N S NG +C
Sbjct: 1031 LHGGTC--QDGCGS---------YRCTCPQGYTGPN-CQNLVHWCDSSPCKNG-GKCWQT 1077
Query: 3746 SDEDHCGGKLTYKARPCKKDEFAC---SNKKCIPMDLQCDRLDDCGDGSDEQGCRIAP-- 3800
+ C + C +C + ++ + + C C D + CR
Sbjct: 1078 HTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY 1137
Query: 3801 TEYTCEDNVN-----PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQC-EDLNECLVFGTC 3854
T CED V+ PC + A C C+C G+ C E+++ECL C
Sbjct: 1138 TGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYH----GVNCSEEIDECLSH-PC 1192
Query: 3855 SH--QCINVEGSYKCVCDQNFQ 3874
+ C+++ +YKC C + Q
Sbjct: 1193 QNGGTCLDLPNTYKCSCPRGTQ 1214
Score = 72.8 bits (177), Expect = 7e-12
Identities = 136/588 (23%), Positives = 197/588 (33%), Gaps = 144/588 (24%)
Query: 2459 DTNSCELSPCALLNGG-CHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFE 2517
D N C P +GG CH+ G C CR C C S
Sbjct: 178 DVNECGQKPGLCRHGGTCHNEV-----GSYRCVCRATHT---GPNCERPYVPC---SPSP 226
Query: 2518 CGNGECI----DYQLTCDGIP-----HCKDKSDEKLLYCENRSCRRGFK-----PCYNRR 2563
C NG D C +P +C++ D+ C +C+ G YN R
Sbjct: 227 CQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD----CPGNNCKNGGACVDGVNTYNCR 282
Query: 2564 CIPH--GKLCDGENDCGDNSDELDCKVSTCATVE--FRCADGTCIP--RSARCNQNID-C 2616
C P G+ C + D TC + C C+ C++NID C
Sbjct: 283 CPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCV---CVNGWTGEDCSENIDDC 339
Query: 2617 ADAS--DEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
A A+ C++ + + + TG + C+ C+ SN C + S+
Sbjct: 340 ASAACFHGATCHDRVASFYCECPHGRTGLL-CHLNDACI--------SNPCNEGSNCDTN 390
Query: 2675 PVQNKHKCEENYFSCPSG-----------RCILNTWICDGQKDCEDGRDEFHCDSSCSWN 2723
PV K C +CPSG C L C+ C + F C +
Sbjct: 391 PVNGKAIC-----TCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT 445
Query: 2724 QFACS--AQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLC 2781
C +C+S C + C D + E IC M +G
Sbjct: 446 GPRCEIDVNECVSNP--CQNDATCLDQIGEFQCIC--------MPGYEGVH--------- 486
Query: 2782 DGERDCPDGSDELSTAGCAPNNTCDE--NAFMCHNKVCIPKQF---VCDHD-DDCGDGSD 2835
C +DE +++ C N C + N F C P F +C +D D+C
Sbjct: 487 -----CEVNTDECASSPCLHNGRCLDKINEFQCE----CPTGFTGHLCQYDVDECAS--- 534
Query: 2836 ESPQCGYRQC--GTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNS 2893
+P +C G ++C T + D D PD
Sbjct: 535 -TPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDP------------------- 574
Query: 2894 SFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HINECLSKKVSGCSQDCQDLPVSYKC 2951
C G C G+ C G +C +INEC S+ CQD +Y C
Sbjct: 575 ----CHYGSC--KDGVATFTCLCRPGYTGHHCETNINECSSQPCRH-GGTCQDRDNAYLC 627
Query: 2952 KCWPGFQLKDDGKTC-VDIDECSSGFPC-SQQCINTYGTYKCLCTDGY 2997
C G G C +++D+C+S PC S C++ Y+C C GY
Sbjct: 628 FCLKG----TTGPNCEINLDDCASS-PCDSGTCLDKIDGYECACEPGY 670
Score = 68.9 bits (167), Expect = 1e-10
Identities = 120/505 (23%), Positives = 178/505 (35%), Gaps = 95/505 (18%)
Query: 796 NMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHIC--------KA 847
N C+ NGG C GG C C + G C+ N + C +
Sbjct: 304 NACQ--NGGT---CHNTHGGYNCVCVNGW----TGEDCSENIDDCASAACFHGATCHDRV 354
Query: 848 GEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNH--------SCPDDQF--KCQNN- 896
F C+ H + C +D C+ + NC + +CP C +
Sbjct: 355 ASFYCECPHG-RTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDV 413
Query: 897 -RCIPKRWLCDGANDC----GSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDR--E 949
C C+ A C GS E + Q T C++D C + C A D+ E
Sbjct: 414 DECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGE 473
Query: 950 DDCGDQTD-EMASCEFPTCEPLTQFVCKSGRCIS--SKWHCDSDDDCGDGSDEVGCVHSC 1006
C E CE T E + +GRC+ +++ C+ C G H C
Sbjct: 474 FQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCE----CPTGFTG----HLC 525
Query: 1007 FDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPD--- 1063
+ C+S C G DG N C E ++ C + +C PD
Sbjct: 526 QYDVDECASTPCKNGAKCLDGPNT---------YTCVCTEGYTGTHCEVDIDECDPDPCH 576
Query: 1064 -GNCVPDL--WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINK--AWVCDG 1118
G+C + + C C G C I C + C G C ++ A++C
Sbjct: 577 YGSCKDGVATFTCL----CRPGYTGHHCETNINECSSQP---CRHGGTCQDRDNAYLCF- 628
Query: 1119 DIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLC----D 1174
C + +C+ L PC D+ CL +K+ + C G G +C D
Sbjct: 629 ---CLKGTTGPNCEINLDDCASSPC--DSGTCL--DKIDGYECACEPGYT-GSMCNINID 680
Query: 1175 ECSLNNGGCSNHCSVVPG-RGIVCSCPEGLQLNKDNKTC-EIVDYCSNHLKCSQVCEQHK 1232
EC+ N C N + G G C CPEG + TC V+ C+++ C
Sbjct: 681 ECAGNP--CHNGGTCEDGINGFTCRCPEGYH----DPTCLSEVNECNSNPCVHGACRDSL 734
Query: 1233 HTVKCSCYEGW---KLDVDGESCTS 1254
+ KC C GW D++ C S
Sbjct: 735 NGYKCDCDPGWSGTNCDINNNECES 759
Score = 67.4 bits (163), Expect = 3e-10
Identities = 167/734 (22%), Positives = 230/734 (31%), Gaps = 180/734 (24%)
Query: 3281 NGGCSHLCLLAPGKTHTCACPTNFY----LAADNRTCLSN----------CTASQFRCKT 3326
N G H+ + C+C F L + CL+N T ++++C+
Sbjct: 70 NAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCR- 128
Query: 3327 DKCIPFWW--KCDTVDDCGD------GSDEPDDC-------PEFR---CQPGRFQCGT-- 3366
C P W C D C G P + P F C+ +CG
Sbjct: 129 --CPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKP 186
Query: 3367 GLCALPAFICDGEND-----CGDNSDELNCDTHVCLSGQFKCTKNQKCIP---VNLRCN- 3417
GLC C E C NC+ C C P V C
Sbjct: 187 GLCRHGG-TCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECAC 245
Query: 3418 --GQDDCGDEEDERDCPENSC--------SPDYFQCKTTKHCISKLWVCDEDPDCADASD 3467
G EE+ DCP N+C + + C+ + C ED D
Sbjct: 246 LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQ--YCTEDVDECQLMP 303
Query: 3468 EANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC--------TLKD 3519
A + TC H N + W + DCS+N D+ C C +
Sbjct: 304 NACQNGGTC--HNTHGGYNCVCVNGW---TGEDCSENIDD--CASAACFHGATCHDRVAS 356
Query: 3520 FLC------------ANGDCVSSRFWCDGDFDCADGSDERNCETS--CSKDQFRCSNGQC 3565
F C N C+S+ C +GS NC+T+ K C +G
Sbjct: 357 FYCECPHGRTGLLCHLNDACISN--------PCNEGS---NCDTNPVNGKAICTCPSGYT 405
Query: 3566 IPAKWKCDGH-EDCKYGEDEKSCEPASP---TCSSREYICAS-----------DGCISAS 3610
PA C ++C G + CE A T S E C + C+S
Sbjct: 406 GPA---CSQDVDECSLGAN--PCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSN- 459
Query: 3611 LKCNGEYDCADGSDEMDCVTECKEDQFRCK-NKAHCIPIRWLCDGIHDCVDGSDEENCE- 3668
C + C D E C+ + C+ N C L +G C+D +E CE
Sbjct: 460 -PCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNG--RCLDKINEFQCEC 516
Query: 3669 ---RGGNICRADEFLCNNSLCKLHFWVCDGED-------------DCGDNSDEA-PDMC- 3710
G++C+ D C ++ CK DG + C + DE PD C
Sbjct: 517 PTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCH 576
Query: 3711 --------VKFLC---PSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKA 3759
F C P H C N I S Q C C D + C
Sbjct: 577 YGSCKDGVATFTCLCRPGYTGHHCETN-INECSSQPCRHGGTCQDRDNAYLCFCLKGTTG 635
Query: 3760 RPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAP--TEYTCEDNV-----NPC 3812
C+ + C++ C C D D C P T C N+ NPC
Sbjct: 636 PNCEINLDDCASSPC--------DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPC 687
Query: 3813 GDDAYCNQIKTSVFCRCKPGFQRNMKNRQC-EDLNECLVFGTCSHQCINVEGSYKCVCD- 3870
+ C CRC G+ + C ++NEC C + YKC CD
Sbjct: 688 HNGGTCEDGINGFTCRCPEGYH----DPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDP 743
Query: 3871 ----QNFQERNNTC 3880
N NN C
Sbjct: 744 GWSGTNCDINNNEC 757
Score = 63.9 bits (154), Expect = 3e-09
Identities = 134/607 (22%), Positives = 194/607 (31%), Gaps = 168/607 (27%)
Query: 2459 DTNSCELSPCALLNGG-CHDLC----LLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
+ N CE +PC +NGG C D+ G +C+ + N C+ + + +
Sbjct: 753 NNNECESNPC--VNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV 810
Query: 2514 SEFECG------NGECIDYQLTCDGIP-----HCKDKSDEKLLYC------ENRSCRRGF 2556
+ ++C C C P C+ D + C + ++C
Sbjct: 811 AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDI 870
Query: 2557 KPCYNRRCIPHGKLCD------------GENDCGDNSDELDCKVSTCATVEFRCADGT-- 2602
C C HG C G + +D DC+ + C C DG
Sbjct: 871 NECVLSPC-RHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGG-SCTDGINT 928
Query: 2603 ----CIP--RSARCNQNI-DCADASDEKNCNNTDCTHFYKLGVKTTGF--IRC-NSTSLC 2652
C+P R C ++I +CA N TDC Y GF I C N+T C
Sbjct: 929 AFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPA-GFSGIHCENNTPDC 987
Query: 2653 VLPTWICDGSNDCGDYSDELKC---PVQNKHKCEENYFSCPSGRCILNTWICDGQKDCED 2709
+ C C D + C P C+ + C S C+ C+D
Sbjct: 988 TESS--CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGG-------TCQD 1038
Query: 2710 GRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQ 2769
G + C +C + Q + HW CD C+
Sbjct: 1039 GCGSYRC--TCPQGYTGPNCQNLV--HW-CDSSP------------------------CK 1069
Query: 2770 GSRACVPRH--WLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFV---- 2823
C H + C+ CP G L CD + C +V +Q V
Sbjct: 1070 NGGKCWQTHTQYRCE----CPSGWTGLY---------CDVPSVSC--EVAAQRQGVDVAR 1114
Query: 2824 -CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNP 2882
C H C D + T C G G + C D DE +P
Sbjct: 1115 LCQHGGLCVDAGN-----------THHCRCQAGYT---------GSY-CEDLVDECSPSP 1153
Query: 2883 KCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HINECLSKKVSGCSQ 2940
A + + CK C G NC I+ECLS
Sbjct: 1154 CQNGATCTDYLGGYSCK----------------CVAGYHGVNCSEEIDECLSHPCQN-GG 1196
Query: 2941 DCQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGF-PCSQQ--------CINTYGTYK 2990
C DLP +YKC C G Q G C +++D+C+ P S+ C++ G Y
Sbjct: 1197 TCLDLPNTYKCSCPRGTQ----GVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYS 1252
Query: 2991 CLCTDGY 2997
C C G+
Sbjct: 1253 CTCPPGF 1259
Score = 59.7 bits (143), Expect = 7e-08
Identities = 146/626 (23%), Positives = 200/626 (31%), Gaps = 151/626 (24%)
Query: 2459 DTNSCELSPCALLNGGCHD----------------LCLLTPNGRVNCSCRGDRILLEDNR 2502
+T+ C SPC L NG C D LC + + C+ L+
Sbjct: 490 NTDECASSPC-LHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPN 548
Query: 2503 ---CVTKNSSCNAYSEFE--------CGNGECID--YQLTCDGIP-----HCKDKSDEKL 2544
CV + E + C G C D TC P HC+ +E
Sbjct: 549 TYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINE-- 606
Query: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCI 2604
C ++ CR G C +R + LC C + +C+++ C GTC+
Sbjct: 607 --CSSQPCRHG-GTCQDR---DNAYLCF----CLKGTTGPNCEINLDDCASSPCDSGTCL 656
Query: 2605 PR-------------SARCNQNID------------CADASDEKNCNNTDCTHFYKLGVK 2639
+ + CN NID C D + C C Y
Sbjct: 657 DKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCR---CPEGYHDPTC 713
Query: 2640 TTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC---PVQNKHKCEENYFSCPSGRCIL 2696
+ CNS CV C D + KC P + C+ N C S C+
Sbjct: 714 LSEVNECNSNP-CV--------HGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV- 763
Query: 2697 NTWICDGQKDCEDG-----RDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
N C KD G R+ F +C N C++ C+++ D D G +
Sbjct: 764 NGGTC---KDMTSGYVCTCREGFS-GPNCQTNINECASNPCLNQGTCID--DVAGYKCNC 817
Query: 2752 SDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNN----TCDE 2807
GA TC + C S C +C D S + P TC+
Sbjct: 818 LLPYTGA-TCEVVLAPCAPSP--------CRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868
Query: 2808 NAFMCHNKVCIPKQFVCDHDDDCGD---GSDESPQCGY--RQCGTEEFSCADGRCLLNTQ 2862
+ C V P C H C + G Q GY R C T+ C
Sbjct: 869 DINEC---VLSP----CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPN------- 914
Query: 2863 WQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDD----CGD 2918
C C D + A + C C + C D D C
Sbjct: 915 -PCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPA 973
Query: 2919 GSDERNCHIN--ECLSKKVSGCSQD--CQDLPVSYKCKCWPGFQLKDDGKTCV-DIDECS 2973
G +C N +C S C C D S+ C C PGF G C D++EC
Sbjct: 974 GFSGIHCENNTPDCTE---SSCFNGGTCVDGINSFTCLCPPGFT----GSYCQHDVNECD 1026
Query: 2974 SGFPCSQ--QCINTYGTYKCLCTDGY 2997
S PC C + G+Y+C C GY
Sbjct: 1027 SQ-PCLHGGTCQDGCGSYRCTCPQGY 1051
Score = 57.4 bits (137), Expect = 3e-07
Identities = 113/478 (23%), Positives = 161/478 (33%), Gaps = 99/478 (20%)
Query: 798 CRVN---NGGCST------LCLAIPGGRVCACAD--NQLLDE---NGTTCTFNPGEALPH 843
CR N NGG T C +PG R C + N+ + NG CT + ++
Sbjct: 911 CRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCT-DCVDSYTC 969
Query: 844 ICKAG--EFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC---FNHS-CPDDQFKCQNNR 897
C AG C+N C C+DG + + C F S C D +C +
Sbjct: 970 TCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP 1029
Query: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQ-----VDQFSCGNGRCIPRAWLCDREDDC 952
C+ DG CGS Q T CQ D C NG + W + C
Sbjct: 1030 CLHGGTCQDG---CGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGG---KCWQTHTQYRC 1083
Query: 953 GDQTDEMAS-CEFPT--CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHS---- 1005
+ C+ P+ CE Q + G ++ C C D + C
Sbjct: 1084 ECPSGWTGLYCDVPSVSCEVAAQ---RQGVDVARL--CQHGGLCVDAGNTHHCRCQAGYT 1138
Query: 1006 ---CFDNQFRCSSGRCIPGHWACD--GDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
C D CS C G D G C + +NC+ EEI C + C
Sbjct: 1139 GSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCS-EEIDE---CLSHP--C 1192
Query: 1061 HPDGNCV--PDLWRCDGEKD-----CEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKA 1113
G C+ P+ ++C + CE D+ CN + K C++ G C+++
Sbjct: 1193 QNGGTCLDLPNTYKCSCPRGTQGVHCEINVDD--CNPPVDPVSRSPK--CFNNGTCVDQV 1248
Query: 1114 WVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE---- 1169
G C C G C D + CL G ++C ++
Sbjct: 1249 ----GGYSCT-------CPPGFVG---ERCEGDVNECLSNPCDARGTQNCVQRVNDFHCE 1294
Query: 1170 ---GYLCDECSLNNGGCSNH-------CSVVPG--RGIVCSCP---EGLQLNKDNKTC 1212
G+ C GC C+V RG +C CP EG D +TC
Sbjct: 1295 CRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTC 1352
Score = 53.1 bits (126), Expect = 6e-06
Identities = 157/721 (21%), Positives = 229/721 (31%), Gaps = 174/721 (24%)
Query: 3277 CMINNGGC-SHLCL-------LAPGKTHTCA-------CPTNFYLAADNR-----TCLSN 3316
C INN C S+ C+ + G TC C TN A N TC+ +
Sbjct: 750 CDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDD 809
Query: 3317 CTASQFRCKTDKCIPFWWK-CDTV------DDCGDGSD--EPDDCPEFRCQ-PGRFQ--- 3363
+ C +P+ C+ V C +G + + +D F C P +Q
Sbjct: 810 VAGYKCNC----LLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQT 865
Query: 3364 CGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCG 3423
C + C C + C SG+ T C P C+ C
Sbjct: 866 CEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNP--CHNGGSCT 923
Query: 3424 D------------------EEDERDCPENSCSP--------DYFQCKTTKHCISKLWVCD 3457
D EED +C + C D + C T S + +
Sbjct: 924 DGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTC-TCPAGFSGIHCEN 982
Query: 3458 EDPDCADASDEANC-DKKTC--GPHEFQC------KNNNCIPDHWRCDSQNDCSDNSDEE 3508
PDC ++S C + TC G + F C + C D CDSQ + ++
Sbjct: 983 NTPDCTESS----CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQD 1038
Query: 3509 NCKPQTCTLKDFLCANG----DCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQ 3564
C CT C G +C + WCD C +G T Q+RC +
Sbjct: 1039 GCGSYRCT-----CPQGYTGPNCQNLVHWCDSS-PCKNGGKCWQTHT-----QYRC---E 1084
Query: 3565 CIPAKWK---CDGHE-DCKYGEDEKSCEPASPTCSSREYICASDG-CISAS----LKCNG 3615
C P+ W CD C+ + + A +C G C+ A +C
Sbjct: 1085 C-PSGWTGLYCDVPSVSCEVAAQRQGVDVAR--------LCQHGGLCVDAGNTHHCRCQA 1135
Query: 3616 EYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIR--WLCD---GIH--DCVDGSDE---E 3665
Y GS D V EC C+N A C + C G H +C + DE
Sbjct: 1136 GYT---GSYCEDLVDECSPSP--CQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH 1190
Query: 3666 NCERGG---NICRADEFLCNNSLCKLHFWVCDGEDDCGD------------NSDEAPDMC 3710
C+ GG ++ + C +H + DDC N+ D
Sbjct: 1191 PCQNGGTCLDLPNTYKCSCPRGTQGVHCEI--NVDDCNPPVDPVSRSPKCFNNGTCVDQV 1248
Query: 3711 VKFLC---PSTRPHRCRNN-RICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDE 3766
+ C P RC + CL + G C ++ HC + + R C+
Sbjct: 1249 GGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVI 1308
Query: 3767 FACSNKKCIPMDLQCDRLDDCGDGSDEQ-----GCRIAPTEYTCEDNVNPCG-----DDA 3816
C K C C S+ C TCE++ CG +
Sbjct: 1309 NGCKGK-------PCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGG 1361
Query: 3817 YCNQIKTSVFCRCKPGFQ----RNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQN 3872
C S C C F + + C N C GTC + + Y+C+C
Sbjct: 1362 TCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTC--EPTSESPFYRCLCPAK 1419
Query: 3873 F 3873
F
Sbjct: 1420 F 1420
Score = 52.8 bits (125), Expect = 8e-06
Identities = 106/464 (22%), Positives = 160/464 (34%), Gaps = 90/464 (19%)
Query: 3522 CAN-GDC--VSSRFWCDGDFDCADGSDERNCET----SCSKDQFRCSNGQC---IPAKWK 3571
C N G C V R D CA G C T +C + R + G C ++K
Sbjct: 68 CKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCR-NGGTCDLLTLTEYK 126
Query: 3572 CDGHEDCKYGEDEKSCEPASPTCSSREYICASDG-CI--SASLKCNGEYDCADGSDEMDC 3628
C C G KSC+ A P S+ CA+ G C+ AS C+ C C
Sbjct: 127 CR----CPPGWSGKSCQQADPCASNP---CANGGQCLPFEASYICH----CPPSFHGPTC 175
Query: 3629 ---VTECKEDQFRCKNKAHCI----PIRWLCDGIHDCVDGSDEENCER-----------G 3670
V EC + C++ C R +C H NCER
Sbjct: 176 RQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHT------GPNCERPYVPCSPSPCQN 229
Query: 3671 GNICRADEFLCNNSLCKLHFWVCDGE---DDCGDNSDEAPDMCVKFL------CPS--TR 3719
G CR + + C F + E DDC N+ + CV + CP T
Sbjct: 230 GGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTG 289
Query: 3720 PHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDL 3779
+ + C C C + +C + C ++ C++ C
Sbjct: 290 QYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGAT 349
Query: 3780 QCDRLD----DCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC--NQIKTSVFCRCKPGF 3833
DR+ +C G C + + NPC + + C N + C C G+
Sbjct: 350 CHDRVASFYCECPHGRTGLLCHLNDACIS-----NPCNEGSNCDTNPVNGKAICTCPSGY 404
Query: 3834 QRNMKNRQCEDLNEC-LVFGTCSH--QCINVEGSYKCVCDQNFQERN-----NTCIAEGS 3885
+ +D++EC L C H +CIN GS++C C Q + N C++
Sbjct: 405 TGPACS---QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPC 461
Query: 3886 EDQVLYIANDTDILGFIYPFNYSGDHQQISHIE-------HNSR 3922
++ + + P Y G H +++ E HN R
Sbjct: 462 QNDATCLDQIGEFQCICMP-GYEGVHCEVNTDECASSPCLHNGR 504
Score = 52.8 bits (125), Expect = 8e-06
Identities = 125/578 (21%), Positives = 186/578 (32%), Gaps = 148/578 (25%)
Query: 2458 NDTNSCELSPCALLNGGCHDLC----LLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
+D N C+ PC L G C D C P G +C+ + + C +
Sbjct: 1020 HDVNECDSQPC-LHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTH 1078
Query: 2514 SEFECGNGECID--YQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLC 2571
+++ C EC L CD +P CE + R+G R HG LC
Sbjct: 1079 TQYRC---ECPSGWTGLYCD-VPSVS---------CEVAAQRQGVDVA---RLCQHGGLC 1122
Query: 2572 DGENDCGDNSDELDCKV----STCATVEFRCADGTCIPRSARCNQ--------------N 2613
D G N+ C+ S C + C+ C A C
Sbjct: 1123 V---DAG-NTHHCRCQAGYTGSYCEDLVDECSPSPC-QNGATCTDYLGGYSCKCVAGYHG 1177
Query: 2614 IDCADASDE---KNCNN----TDCTHFYKLGV-KTTGFIRCNSTSLCVLPTWICDGSNDC 2665
++C++ DE C N D + YK + T + C +DC
Sbjct: 1178 VNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINV------------DDC 1225
Query: 2666 GDYSDELKCPVQNKHKCEEN----------YFSCPSG-----------RCILNTWICDGQ 2704
D PV KC N +CP G C+ N G
Sbjct: 1226 NPPVD----PVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGT 1281
Query: 2705 KDCEDGRDEFHCD--------------SSCSW----NQFACSAQKCISKHWICDGEDDCG 2746
++C ++FHC+ + C N C+ ++ +IC
Sbjct: 1282 QNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFE 1341
Query: 2747 DGLDESDS-ICGAITCAADMFSCQGSRA--CVPRHWLCDGERDCPDGSDELSTAGCAPNN 2803
E+D+ CG++ C G R+ C+ E P S L C
Sbjct: 1342 GATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQG 1401
Query: 2804 TCDENAFMCHNKVCIPKQF------VCDHDDDCGDGSD----------ESPQC----GYR 2843
TC+ + + P +F + D+ G G D E P+C G +
Sbjct: 1402 TCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNK 1461
Query: 2844 ----QCGTEEFSCADGRCLL--NTQWQ-CDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFF 2896
QC G C L N W+ C C + + + +C SA C F
Sbjct: 1462 VCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSA--GCLFDGF 1519
Query: 2897 MCK--NGRCIPSGGLCDN--KDDCGDGSDERNCHINEC 2930
C+ G+C P L D KD DG ++ C+ EC
Sbjct: 1520 DCQRAEGQCNP---LYDQYCKDHFSDGHCDQGCNSAEC 1554
Score = 52.0 bits (123), Expect = 1e-05
Identities = 54/178 (30%), Positives = 66/178 (37%), Gaps = 39/178 (21%)
Query: 56 PDCPDDSDE-SLDTCPEEVEIKC--PLNHIAC------------LGTNKCVH-------- 92
P C D DE SL P E KC L C + N+CV
Sbjct: 407 PACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDAT 466
Query: 93 -LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITED 149
L Q+ C GY EGVHC+ C C + +C N +C C GF
Sbjct: 467 CLDQIGEFQCICMPGY-EGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFT---- 521
Query: 150 GRSCK-DQDECAVYGTCSQ--TCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
G C+ D DECA C C + +YTC C EGY C+ I+ D P
Sbjct: 522 GHLCQYDVDECAST-PCKNGAKCLDGPNTYTCVCTEGY----TGTHCEVDIDECDPDP 574
Score = 50.8 bits (120), Expect = 3e-05
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 16/148 (10%)
Query: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVE-IKCPLNHIACLGTNKCVH----LSQLCNG 99
CVS C D C D E C E + C +N C ++ C+H L ++
Sbjct: 456 CVSNP--CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDEC-ASSPCLHNGRCLDKINEF 512
Query: 100 VLDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQ 156
+CP G+ G CQ + C C+ KC N+ C C +G+ G C+ D
Sbjct: 513 QCECPTGFT-GHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYT----GTHCEVDI 567
Query: 157 DECAVYGTCSQTCRNTHGSYTCSCVEGY 184
DEC +C++ ++TC C GY
Sbjct: 568 DECDPDPCHYGSCKDGVATFTCLCRPGY 595
Score = 50.8 bits (120), Expect = 3e-05
Identities = 31/87 (35%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQYKCTMVR--NSTRCYCEDGFE---ITEDGRSCKDQD 157
CP G+ G+HC+ +C + +C T V NS C C GF D C D
Sbjct: 971 CPAGFS-GIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNEC-DSQ 1028
Query: 158 ECAVYGTCSQTCRNTHGSYTCSCVEGY 184
C GTC C GSY C+C +GY
Sbjct: 1029 PCLHGGTCQDGC----GSYRCTCPQGY 1051
Score = 49.3 bits (116), Expect = 9e-05
Identities = 50/184 (27%), Positives = 77/184 (41%), Gaps = 32/184 (17%)
Query: 32 CDPGEFLCHDHVTCVSQSWLCDGDP-----DCPDDSDESLDTCPEEVE-IKCPLNHIACL 85
CDPG C + C+ +P C D + + TC E C N C
Sbjct: 741 CDPG----WSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINEC- 795
Query: 86 GTNKCVHLSQLCNGVL----DCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRN--STR 137
+N C++ + V +C Y G C+ +L+ C C+ +C + S
Sbjct: 796 ASNPCLNQGTCIDDVAGYKCNCLLPYT-GATCEVVLAPCAPSPCRNGGECRQSEDYESFS 854
Query: 138 CYCEDGFEITEDGRSCK-DQDECAVYGTCSQ--TCRNTHGSYTCSCVEGYLMQPDNRSCK 194
C C G++ G++C+ D +EC V C +C+NTHG Y C C GY R+C+
Sbjct: 855 CVCPTGWQ----GQTCEVDINEC-VLSPCRHGASCQNTHGGYRCHCQAGY----SGRNCE 905
Query: 195 AKIE 198
I+
Sbjct: 906 TDID 909
Score = 48.9 bits (115), Expect = 1e-04
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 11/88 (12%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSC-KDQDEC 159
C G+ G +C+E + +C NC+ C N+ C C + G+ C +D DEC
Sbjct: 245 CLPGFT-GQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWT----GQYCTEDVDEC 299
Query: 160 AVYGTCSQ---TCRNTHGSYTCSCVEGY 184
+ Q TC NTHG Y C CV G+
Sbjct: 300 QLMPNACQNGGTCHNTHGGYNCVCVNGW 327
Score = 48.5 bits (114), Expect = 2e-04
Identities = 54/210 (25%), Positives = 75/210 (35%), Gaps = 52/210 (24%)
Query: 3707 PDMCVKFLCPSTRPHRCRNNRICLQSEQMC--NGIDECGDNSDEDHCGGKLTYK------ 3758
P + LC + P C Q + C G E + ++ CGG
Sbjct: 2 PPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPN 61
Query: 3759 ---ARPCKKD------------EFACS------NKKCI-PMDLQCDRLDDCGDGSD---- 3792
+ PCK ++ACS C+ P+D C + C +G
Sbjct: 62 PCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNAC-LTNPCRNGGTCDLL 120
Query: 3793 ---EQGCRIAP--TEYTCEDN----VNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQC- 3842
E CR P + +C+ NPC + C + S C C P F C
Sbjct: 121 TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH----GPTCR 176
Query: 3843 EDLNEC-LVFGTCSH--QCINVEGSYKCVC 3869
+D+NEC G C H C N GSY+CVC
Sbjct: 177 QDVNECGQKPGLCRHGGTCHNEVGSYRCVC 206
Score = 48.5 bits (114), Expect = 2e-04
Identities = 51/180 (28%), Positives = 68/180 (37%), Gaps = 38/180 (21%)
Query: 31 LCDPG---EFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHI----- 82
LC PG + HD C SQ L G C D TCP+ N +
Sbjct: 1008 LCPPGFTGSYCQHDVNECDSQPCLHGGT--CQDGCGSYRCTCPQGYTGPNCQNLVHWCDS 1065
Query: 83 -ACLGTNKC--VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN----------CQYK- 128
C KC H C +CP G+ G++C +C+ CQ+
Sbjct: 1066 SPCKNGGKCWQTHTQYRC----ECPSGWT-GLYCDVPSVSCEVAAQRQGVDVARLCQHGG 1120
Query: 129 -CTMVRNSTRCYCEDGFEITEDGRSCKDQ-DECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
C N+ C C+ G+ G C+D DEC+ C TC + G Y+C CV GY
Sbjct: 1121 LCVDAGNTHHCRCQAGYT----GSYCEDLVDECSP-SPCQNGATCTDYLGGYSCKCVAGY 1175
Score = 43.5 bits (101), Expect = 0.005
Identities = 45/183 (24%), Positives = 71/183 (38%), Gaps = 21/183 (11%)
Query: 32 CDPGEF--LCHDHVT-CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTN 88
C+PG +C+ ++ C C C D + CPE L+ + +N
Sbjct: 666 CEPGYTGSMCNINIDECAGNP--CHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSN 723
Query: 89 KCVH--LSQLCNGV-LDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDG 143
CVH NG DC G+ G +C + C+ C C + + C C +G
Sbjct: 724 PCVHGACRDSLNGYKCDCDPGW-SGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREG 782
Query: 144 FEITEDGRSCKDQ-DECAVYGTCSQ-TCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTD 201
F G +C+ +ECA +Q TC + Y C+C+ Y +C+ + P
Sbjct: 783 F----SGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPY----TGATCEVVLAPCA 834
Query: 202 RPP 204
P
Sbjct: 835 PSP 837
Score = 42.0 bits (97), Expect = 0.014
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 8/85 (9%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQDEC 159
C GY G HC+ ++ C C++ C N+ C+C G G +C+ + D+C
Sbjct: 591 CRPGYT-GHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKG----TTGPNCEINLDDC 645
Query: 160 AVYGTCSQTCRNTHGSYTCSCVEGY 184
A S TC + Y C+C GY
Sbjct: 646 ASSPCDSGTCLDKIDGYECACEPGY 670
Score = 41.2 bits (95), Expect = 0.024
Identities = 30/101 (29%), Positives = 42/101 (41%), Gaps = 10/101 (9%)
Query: 2898 CKNGRCIPSGGLCDNKDDCGDGSDERNCH-INECLSKKVSGCSQDCQDLPVSYKCKCWPG 2956
C+NG L + K C G ++C + C S + Q C SY C C P
Sbjct: 111 CRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQ-CLPFEASYICHCPPS 169
Query: 2957 FQLKDDGKTC-VDIDECSSGFPCSQQ---CINTYGTYKCLC 2993
F G TC D++EC + C N G+Y+C+C
Sbjct: 170 FH----GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVC 206
Score = 37.4 bits (85), Expect = 0.35
Identities = 30/91 (32%), Positives = 40/91 (43%), Gaps = 19/91 (20%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQDEC 159
C GY G +C+ + +C+ C CT N+ C C GF G C+ D +EC
Sbjct: 895 CQAGYS-GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFR----GTFCEEDINEC 949
Query: 160 AVYGTCSQTCRNTHG------SYTCSCVEGY 184
A S CRN SYTC+C G+
Sbjct: 950 A-----SDPCRNGANCTDCVDSYTCTCPAGF 975
Score = 36.6 bits (83), Expect = 0.59
Identities = 34/132 (25%), Positives = 51/132 (38%), Gaps = 24/132 (18%)
Query: 60 DDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQ---EL 116
+D E++D C AC C ++ + +CP G G+ C
Sbjct: 330 EDCSENIDDCASA----------ACFHGATCH--DRVASFYCECPHGRT-GLLCHLNDAC 376
Query: 117 LSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSC-KDQDECAVYGT-CSQT--CRNT 172
+SN V C C G+ G +C +D DEC++ C C NT
Sbjct: 377 ISNPCNEGSNCDTNPVNGKAICTCPSGYT----GPACSQDVDECSLGANPCEHAGKCINT 432
Query: 173 HGSYTCSCVEGY 184
GS+ C C++GY
Sbjct: 433 LGSFECQCLQGY 444
Score = 35.8 bits (81), Expect = 1.0
Identities = 38/114 (33%), Positives = 48/114 (42%), Gaps = 19/114 (16%)
Query: 78 PLNHIACLGTNKCVH-----LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQY--KCT 130
PL++ ACL TN C + L L CP G+ G CQ+ C C +C
Sbjct: 101 PLDN-ACL-TNPCRNGGTCDLLTLTEYKCRCPPGWS-GKSCQQA-DPCASNPCANGGQCL 156
Query: 131 MVRNSTRCYCEDGFEITEDGRSCK-DQDECAVY-GTCSQ--TCRNTHGSYTCSC 180
S C+C F G +C+ D +EC G C TC N GSY C C
Sbjct: 157 PFEASYICHCPPSFH----GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVC 206
Score = 35.4 bits (80), Expect = 1.3
Identities = 28/99 (28%), Positives = 39/99 (39%), Gaps = 25/99 (25%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQ-----------YKCTMVRNSTRCYCEDGFE-----I 146
C GY GV+C E + C CQ YKC+ R + +CE + +
Sbjct: 1171 CVAGY-HGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPV 1229
Query: 147 TEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYL 185
RS K C GTC G Y+C+C G++
Sbjct: 1230 DPVSRSPK----CFNNGTCVDQV----GGYSCTCPPGFV 1260
Score = 34.7 bits (78), Expect = 2.3
Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 9/79 (11%)
Query: 110 GVHCQELLSNCQQLNCQY-KCTMVRNSTRCYCEDGFEITEDGRSCK-DQDECAVYGTCSQ 167
G +C+ L +C C C + C CE G+ G C + DECA C
Sbjct: 635 GPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYT----GSMCNINIDECAG-NPCHN 689
Query: 168 --TCRNTHGSYTCSCVEGY 184
TC + +TC C EGY
Sbjct: 690 GGTCEDGINGFTCRCPEGY 708
Score = 33.5 bits (75), Expect = 5.0
Identities = 98/406 (24%), Positives = 148/406 (36%), Gaps = 78/406 (19%)
Query: 789 PRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADN-QLLDE-NGTTCTFNPGEALPHICK 846
PR QG + C +N C+ P R C +N +D+ G +CT PG + C+
Sbjct: 1210 PRGTQGVH-CEINVDDCNPP--VDPVSRSPKCFNNGTCVDQVGGYSCTCPPG-FVGERCE 1265
Query: 847 AGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQF--KCQN--NRCIPKR 902
C + C AR G +C+ VN F+ C +C++ N C K
Sbjct: 1266 GDVNECLSNPC-DAR----GTQNCVQ-----RVNDFHCECRAGHTGRRCESVINGCKGKP 1315
Query: 903 WLCDGANDCGSNEDESNQ---TCTA----RTCQVDQFSCGNGRCIPRAWLC---DREDDC 952
C C + + C A TC+ D +CG+ RC+ C R C
Sbjct: 1316 --CKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCL-NGGTCISGPRSPTC 1372
Query: 953 ---GDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDD-----CGDGSDEVGCVH 1004
G T C+FP P C G ++ C+ + C + G +
Sbjct: 1373 LCLGPFTG--PECQFPASSP-----CLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLC 1425
Query: 1005 SCFDNQFRCSSGRCIPG---HWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCH 1061
D F +GR IP AC+ +C + D C+ + + G +G + +
Sbjct: 1426 HILDYSFGGGAGRDIPPPLIEEACELP-ECQE--DAGNKVCSLQCNNHACGWDGGDCSLN 1482
Query: 1062 ---PDGNCVPDL--WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCW-STGRCINKAWV 1115
P NC L W+ + C+ + GC L D F C + G+C N +
Sbjct: 1483 FNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGC-----LFD---GFDCQRAEGQC-NPLY- 1532
Query: 1116 CDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQ--PEKLCNG 1159
D C+D + CD G C D C + PE+L G
Sbjct: 1533 ---DQYCKDHFSDGHCDQ---GCNSAECEWDGLDCAEHVPERLAAG 1572
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 123 bits (309), Expect = 4e-27
Identities = 100/319 (31%), Positives = 134/319 (42%), Gaps = 66/319 (20%)
Query: 4151 LALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCL-LNPSGATCVCPEGKYLINGTCND 4209
L +++ + +G+L P PC + CL L+ TC C G + TC
Sbjct: 16 LCVSVVRPRGLLCG------SFPEPCANGGT---CLSLSLGQGTCQCAPG--FLGETCQ- 63
Query: 4210 DSLLDDSCKLT--CENGGRCILNEKGDLR-------------CHCWPSYSGERCEV---N 4251
D C+ C+NGG C L C C P ++GERC+ +
Sbjct: 64 ---FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED 120
Query: 4252 HCS-NYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQ-----NGGTCIVTAGN 4305
C ++C G C GRP CSC G+TG C DFC NGG C+ T
Sbjct: 121 PCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC---QLRDFCSANPCVNGGVCLATY-P 176
Query: 4306 QPYCHCQPEYTGDRCQYYVCHHY-----CVNSESCTIGDDGSVECVCPTRYEGPKCEVDK 4360
Q CHC P + G C+ V + C SC GS +C+CP EGP+CE+ +
Sbjct: 177 QIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCH-NTLGSFQCLCPVGQEGPRCEL-R 234
Query: 4361 CVRC------HGGHCII--NKDSEDIFCNCTNGKIASSCQL----CDGY-CYNGGTCQLD 4407
C +GG C + KDS C C G I C++ C + C NGGTCQ
Sbjct: 235 AGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDG 294
Query: 4408 PETNVPVCLCSTNWSGTQC 4426
+T CLC W+G C
Sbjct: 295 LDTY--TCLCPETWTGWDC 311
Score = 112 bits (281), Expect = 7e-24
Identities = 93/297 (31%), Positives = 125/297 (42%), Gaps = 81/297 (27%)
Query: 4176 CLDLACEFLCLLNPSGAT-------------C----VCPEGKYLINGTCNDDSL----LD 4214
CLDL F CL PSG T C +C + K N C D S +
Sbjct: 604 CLDLPGAFFCLC-PSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPE 662
Query: 4215 DSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCE--VNHC-SNYCQNGGTCVPSVLGRP 4271
D+C TC +G C + C C ++G CE + C S C +GGTC P G
Sbjct: 663 DNC--TCHHG-HCQRSS-----CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGY- 713
Query: 4272 TCSCALGFTGPNCGK--TVCEDF-CQNGGTCIVTAGNQPYCHCQPEYTGDRCQY---YVC 4325
C+C G+TGP C + T C C NGG+C + G YC C P +TG +CQ Y
Sbjct: 714 NCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGY-YCTCPPSHTGPQCQTSTDYCV 772
Query: 4326 HHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNG 4385
C N +C + G+ C+C ++GP+CE G
Sbjct: 773 SAPCFNGGTC-VNRPGTFSCLCAMGFQGPRCE---------------------------G 804
Query: 4386 KIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQC--------ERPAPKSS 4434
K+ SC D C N TCQ P+ P CLC T ++G C ++P P++S
Sbjct: 805 KLRPSC--ADSPCRNRATCQDSPQG--PRCLCPTGYTGGSCQTLMDLCAQKPCPRNS 857
Score = 101 bits (251), Expect = 2e-20
Identities = 91/315 (28%), Positives = 126/315 (40%), Gaps = 76/315 (24%)
Query: 4172 LPNPCLDLAC--EFLCLLNP-SGAT-CVCPEGKYLINGTCN---DDSLLDDSCKLTCENG 4224
L + CL C + C NP +G+T C+C G TC+ D+ L+ CE+G
Sbjct: 392 LEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPG--YSGPTCHQDLDECLMAQQGPSPCEHG 449
Query: 4225 GRCILNEKGDLRCHCWPSYSGERCEVNH---CSNYCQNGGTCVP---------------- 4265
G C LN G C C P Y+G RCE +H S C G TC+
Sbjct: 450 GSC-LNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQ 508
Query: 4266 ---------------------SVLGRPTCSCALGFTGPNCGKTVCE---DFCQNGGTCIV 4301
+L C C GF+G C + + E C NGG C
Sbjct: 509 LCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQC-- 566
Query: 4302 TAGNQP---YCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDD-----GSVECVCPTRYEG 4353
+QP +C C P + G RCQ V C+ S+ C +G G+ C+CP+ + G
Sbjct: 567 --QDQPGAFHCKCLPGFEGPRCQTEV--DECL-SDPCPVGASCLDLPGAFFCLCPSGFTG 621
Query: 4354 PKCEVDKCVRCHGGHCIINKDSED-IFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNV 4412
CEV C I KD +D C C +G + + C++ G CQ
Sbjct: 622 QLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHH-GHCQRSS---- 676
Query: 4413 PVCLCSTNWSGTQCE 4427
C+C W+G +CE
Sbjct: 677 --CVCDVGWTGPECE 689
Score = 100 bits (250), Expect = 3e-20
Identities = 89/285 (31%), Positives = 115/285 (40%), Gaps = 39/285 (13%)
Query: 4176 CLDLACEF--LCLLNPSGATCVCPEGKYLINGTCNDDSLLDD-SCKLTCENGGRCILNEK 4232
CL F LCL +G C P +C +L C NGG C+ +
Sbjct: 859 CLQTGPSFHCLCLQGWTGPLCNLPLS------SCQKAALSQGIDVSSLCHNGGLCV-DSG 911
Query: 4233 GDLRCHCWPSYSGERCE--VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV- 4288
CHC P + G C+ VN C S CQNG TC+ G C CA G+ G NC K +
Sbjct: 912 PSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGY-LCQCAPGYDGQNCSKELD 970
Query: 4289 -CEDF-CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDG----- 4341
C+ C N GTC G +C C P + G RC+ V C++ G
Sbjct: 971 ACQSQPCHNHGTCTPKPGGF-HCACPPGFVGLRCEGDVDE--CLDQPCHPTGTAACHSLA 1027
Query: 4342 -SVECVCPTRYEGPKCEV--DKCVR---CHGGHCIINKDSE-DIFCNCTNGKIASSCQ-- 4392
+ C C + G CEV D C HGG C S C+C G +C
Sbjct: 1028 NAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHR 1087
Query: 4393 --LCD-GYCYNGGTCQLDPETNVPV-CLCSTNWSGTQC-ERPAPK 4432
C +C++GG C P+ P C C + + G C PAPK
Sbjct: 1088 APSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPK 1132
Score = 92.4 bits (228), Expect = 9e-18
Identities = 85/280 (30%), Positives = 106/280 (37%), Gaps = 36/280 (12%)
Query: 4174 NPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKG 4233
NPC++ +CL C CP G C D C G C N G
Sbjct: 163 NPCVNGG---VCLATYPQIQCHCPPG--FEGHACERDVNECFQDPGPCPKGTSCH-NTLG 216
Query: 4234 DLRCHCWPSYSGERCEVNH--CS-NYCQNGGTCVPSVLGRPT---CSCALGFTGPNCG-- 4285
+C C G RCE+ C C NGGTC T C C GF GP+C
Sbjct: 217 SFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVN 276
Query: 4286 -KTVCEDFCQNGGTCIVTAGNQPY-CHCQPEYTG-------DRCQYYVCHHYCVNSESCT 4336
CQNGGTC G Y C C +TG D C+ H C N +C
Sbjct: 277 PDNCVSHQCQNGGTC--QDGLDTYTCLCPETWTGWDCSEDVDECETQGPPH-CRNGGTCQ 333
Query: 4337 IGDDGSVECVCPTRYEGPKCE--VDKCVR--CHGGHCIINKDSEDIFCNCTNGKIASSCQ 4392
GS CVC + + G CE +D C+ C G I++ C C G+ C
Sbjct: 334 -NSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGS-FSCLCPPGRTGLLCH 391
Query: 4393 LCDGY----CYNGGTCQLDPETNVPVCLCSTNWSGTQCER 4428
L D C+ C +P T +CLC +SG C +
Sbjct: 392 LEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQ 431
Score = 88.6 bits (218), Expect = 1e-16
Identities = 84/320 (26%), Positives = 107/320 (33%), Gaps = 79/320 (24%)
Query: 4175 PCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGD 4234
PCL+ C +P G C CP C + D C NGG C+ N G
Sbjct: 737 PCLNGGS---CNPSPGGYYCTCPPSH--TGPQCQTST--DYCVSAPCFNGGTCV-NRPGT 788
Query: 4235 LRCHCWPSYSGERCEVN---HCSNY-CQNGGTCVPSVLGRPTCSCALGFTGPN------- 4283
C C + G RCE C++ C+N TC S G P C C G+TG +
Sbjct: 789 FSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQG-PRCLCPTGYTGGSCQTLMDL 847
Query: 4284 CGKTVC--------------------------------------------EDFCQNGGTC 4299
C + C C NGG C
Sbjct: 848 CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLC 907
Query: 4300 IVTAGNQPYCHCQPEYTGDRCQYYV--CH-HYCVNSESCTIGDDGSVECVCPTRYEGPKC 4356
V +G +CHC P + G CQ +V C C N +C G + C C Y+G C
Sbjct: 908 -VDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYL-CQCAPGYDGQNC 965
Query: 4357 --EVDKCVR--CHGGHCIINKDSEDIFCNCTNGKIASSC-----QLCDGYCYNGGTCQLD 4407
E+D C CH H C C G + C + D C+ GT
Sbjct: 966 SKELDACQSQPCH-NHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACH 1024
Query: 4408 PETNVPVCLCSTNWSGTQCE 4427
N C C +G CE
Sbjct: 1025 SLANAFYCQCLPGHTGQWCE 1044
Score = 86.3 bits (212), Expect = 7e-16
Identities = 71/241 (29%), Positives = 96/241 (39%), Gaps = 71/241 (29%)
Query: 4257 CQNGGTCVPSVLGRPTCSCALGFTGPNCG-KTVCED--FCQNGGTCI--------VTAGN 4305
C NGGTC+ LG+ TC CA GF G C C++ CQNGG+C + +
Sbjct: 35 CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94
Query: 4306 QP-----YCHCQPEYTGDRCQYYV---C-HHYCVNSESCTIGDDGSVECVCPTRYEGPKC 4356
P C C P +TG+RCQ + C +C C I G +C C + G +C
Sbjct: 95 SPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC 154
Query: 4357 EV-DKC-----------------VRCH-----GGHCIINKDSEDIF-------------- 4379
++ D C ++CH GH +D + F
Sbjct: 155 QLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHA-CERDVNECFQDPGPCPKGTSCHN 213
Query: 4380 ------CNCTNGKIASSCQLCDG-----YCYNGGTCQLDPE--TNVPVCLCSTNWSGTQC 4426
C C G+ C+L G C NGGTCQL PE + +CLC + G C
Sbjct: 214 TLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDC 273
Query: 4427 E 4427
E
Sbjct: 274 E 274
Score = 75.9 bits (185), Expect = 9e-13
Identities = 60/202 (29%), Positives = 74/202 (36%), Gaps = 24/202 (11%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYS 4244
C P G C CP G + + D LD C T + N C C P ++
Sbjct: 983 CTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANA---FYCQCLPGHT 1039
Query: 4245 GERCEV--NHC-SNYCQNGGTCVPSVLGRP---TCSCALGFTGPNCGKTVCE---DFCQN 4295
G+ CEV + C S C +GGTC + G P C C GF GP C C +
Sbjct: 1040 GQWCEVEIDPCHSQPCFHGGTC-EATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHH 1098
Query: 4296 GGTCIVT--AGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESC--------TIGDDG-SVE 4344
GG C+ + G P C C Y G C C C T G G
Sbjct: 1099 GGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFR 1158
Query: 4345 CVCPTRYEGPKCEVDKCVRCHG 4366
C CP GP+C+ C G
Sbjct: 1159 CSCPHSSPGPRCQKPGAKGCEG 1180
Score = 72.4 bits (176), Expect = 1e-11
Identities = 104/410 (25%), Positives = 147/410 (35%), Gaps = 130/410 (31%)
Query: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACS--AQKCISKHWIC 2739
CE N +C S +C C+DG D + C +W + CS +C ++
Sbjct: 273 CEVNPDNCVSHQC-------QNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQ---- 321
Query: 2740 DGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
G C +G G +A F C CV W G C + D+ A C
Sbjct: 322 -GPPHCRNG--------GTCQNSAGSFHC----VCVSG-W---GGTSCEENLDDCIAATC 364
Query: 2800 APNNTCDEN--AFMCHNKVCIPKQ--FVCDHDDDCGDGSDESPQCGYRQCGTEEFS---- 2851
AP +TC + +F C +C P + +C +D C P G QC T +
Sbjct: 365 APGSTCIDRVGSFSC---LCPPGRTGLLCHLEDMCLS----QPCHGDAQCSTNPLTGSTL 417
Query: 2852 --CADG-----------RCLLNTQWQ--CD---------GDFDC---PDHSDEAPLNPKC 2884
C G CL+ Q C+ G F+C P ++ +C
Sbjct: 418 CLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGS-----RC 472
Query: 2885 KSAEQSCNSSFFMCKNGR------------CIPS--GGLCD------------NKDDCGD 2918
++ C S C G C P G LC+ N DC D
Sbjct: 473 EADHNECLSQ--PCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHD 530
Query: 2919 -----------GSDERNCH--INECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKT 2965
G C I+EC S + Q CQD P ++ CKC PGF +G
Sbjct: 531 LLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQ-CQDQPGAFHCKCLPGF----EGPR 585
Query: 2966 C-VDIDEC-SSGFPCSQQCINTYGTYKCLCTDGY-----EIQPDNPNGCK 3008
C ++DEC S P C++ G + CLC G+ E+ PN C+
Sbjct: 586 CQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQ 635
Score = 67.8 bits (164), Expect = 2e-10
Identities = 150/664 (22%), Positives = 209/664 (31%), Gaps = 179/664 (26%)
Query: 3283 GCSH--LCLLAPGKT---HTCACPTNFYLAADNRTCLSNCTASQFR----CK----TDKC 3329
GCS+ C L P K H C CP F + D NC + Q + C+ T C
Sbjct: 242 GCSNGGTCQLMPEKDSTFHLCLCPPGF-IGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC 300
Query: 3330 I-PFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICD-----GENDCG 3383
+ P W T DC + DE + C+ G GT + +F C G C
Sbjct: 301 LCPETW---TGWDCSEDVDECETQGPPHCRNG----GTCQNSAGSFHCVCVSGWGGTSCE 353
Query: 3384 DNSDELNCDT----HVCLS--GQFKCTKNQKCIP--VNLRCNGQDDCGDEEDERDCPENS 3435
+N D+ T C+ G F C C P L C+ +D C + D
Sbjct: 354 ENLDDCIAATCAPGSTCIDRVGSFSCL----CPPGRTGLLCHLEDMCLSQPCHGDA---- 405
Query: 3436 CSPDYFQCKTTKHCISKLWVCD---EDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDH 3492
QC T S L +C P C DE C GP
Sbjct: 406 ------QCSTNPLTGSTLCLCQPGYSGPTCHQDLDE--CLMAQQGPSP------------ 445
Query: 3493 WRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETS 3552
C+ C + NC LC G S
Sbjct: 446 --CEHGGSCLNTPGSFNC----------LCPPGYTGS----------------------R 471
Query: 3553 CSKDQFRCSNGQCIPAKWKCD----GHEDCKYGEDEKSCEPASPTCSSREYICASDGCIS 3608
C D C + C P D H C G + + CE + C+S
Sbjct: 472 CEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECAS------------ 519
Query: 3609 ASLKCNGEYDCADGSDEMDCV-------TECKEDQFRCK-----NKAHC--IPIRWLCDG 3654
C DC D + C+ T C+ED C+ N C P + C
Sbjct: 520 --APCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHC-- 575
Query: 3655 IHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFL 3714
C+ G + C+ + C +D S L G C S +C L
Sbjct: 576 --KCLPGFEGPRCQTEVDECLSDPCPVGASCLDL-----PGAFFCLCPSGFTGQLCEVPL 628
Query: 3715 CPSTRPHRCRNNRICLQSEQMCNGIDECGDNS-----DEDHCGGKLTYKARPCKKDEFAC 3769
C P+ C+ +IC + N + C D S ED+C T C++ C
Sbjct: 629 C---APNLCQPKQICKDQKDKANCL--CPDGSPGCAPPEDNC----TCHHGHCQRSSCVC 679
Query: 3770 ----SNKKCIP-----MDLQCDRLDDCGDGSDEQGCRIAPTEY---TCEDNV-----NPC 3812
+ +C + C C C PT Y TC + + PC
Sbjct: 680 DVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNC-TCPTGYTGPTCSEEMTACHSGPC 738
Query: 3813 GDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSH--QCINVEGSYKCVCD 3870
+ CN +C C P + QC+ + V C + C+N G++ C+C
Sbjct: 739 LNGGSCNPSPGGYYCTCPP----SHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCA 794
Query: 3871 QNFQ 3874
FQ
Sbjct: 795 MGFQ 798
Score = 67.0 bits (162), Expect = 4e-10
Identities = 101/441 (22%), Positives = 150/441 (34%), Gaps = 116/441 (26%)
Query: 3478 PHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP----QTCTLKDFLCAN-----GDCV 3528
P F K C H + + CS C P + C L+DF AN G C+
Sbjct: 123 PPSFCSKRGRC---HIQASGRPQCS-------CMPGWTGEQCQLRDFCSANPCVNGGVCL 172
Query: 3529 SSRFWCDGDFDCADGSDERNCE---TSCSKDQFRCSNGQCIP---AKWKCDGHEDCKYGE 3582
++ + C G + CE C +D C G ++C C G+
Sbjct: 173 AT--YPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCL----CPVGQ 226
Query: 3583 DEKSCEPASPTCSSREYICASDGCISASLKCNGEYD---CADGSDEMDCVTECKEDQFRC 3639
+ CE + C R C++ G + + + C G DC
Sbjct: 227 EGPRCELRAGPCPPRG--CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEV--------- 275
Query: 3640 KNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDC 3699
N +C+ + C C DG D C LC + W DC
Sbjct: 276 -NPDNCVSHQ--CQNGGTCQDGLDTYTC------------LCPETWTG---W------DC 311
Query: 3700 GDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKA 3759
++ DE C + P CRN C S + HC +
Sbjct: 312 SEDVDE---------CETQGPPHCRNGGTCQNS-------------AGSFHCVCVSGWGG 349
Query: 3760 RPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTC--EDNV--NPCGDD 3815
C+++ C C P DR+ GS C T C ED PC D
Sbjct: 350 TSCEENLDDCIAATCAPGSTCIDRV-----GSFSCLCPPGRTGLLCHLEDMCLSQPCHGD 404
Query: 3816 AYC--NQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVF----GTCSH--QCINVEGSYKC 3867
A C N + S C C+PG+ + +DL+ECL+ C H C+N GS+ C
Sbjct: 405 AQCSTNPLTGSTLCLCQPGYSGPTCH---QDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461
Query: 3868 VCDQNF-----QERNNTCIAE 3883
+C + + +N C+++
Sbjct: 462 LCPPGYTGSRCEADHNECLSQ 482
Score = 67.0 bits (162), Expect = 4e-10
Identities = 144/664 (21%), Positives = 209/664 (31%), Gaps = 153/664 (23%)
Query: 3284 CSH--LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDD 3341
C H CL PG + C CP + S C A C + C P
Sbjct: 446 CEHGGSCLNTPG-SFNCLCPPGY--------TGSRCEADHNECLSQPCHP---------- 486
Query: 3342 CGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGE-NDCGDNSDELNCDTHVCLSGQ 3400
GS D F C C GL +C+ E N+C + D H L+G
Sbjct: 487 ---GSTCLDLLATFHCL-----CPPGL---EGQLCEVETNECASAPCLNHADCHDLLNG- 534
Query: 3401 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS--------PDYFQCKTTK----- 3447
F+C C+P G EED +C + C+ P F CK
Sbjct: 535 FQCI----CLP------GFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGP 584
Query: 3448 HCISKLWVCDEDP-----DCADASDEANCDKKTCGPHEFQ---CKNNNCIPDHWRCDSQN 3499
C +++ C DP C D C C P F C+ C P+ C +
Sbjct: 585 RCQTEVDECLSDPCPVGASCLDLPGAFFC---LC-PSGFTGQLCEVPLCAPN--LCQPKQ 638
Query: 3500 DCSDNSDEENC-----------KPQTCTLKDFLCANGDCVSSRFW----CDGDFD----- 3539
C D D+ NC CT C CV W C+ +
Sbjct: 639 ICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISA 698
Query: 3540 -CADGSD--------ERNCET-----SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEK 3585
CA G C T +CS++ C +G C+ G + G
Sbjct: 699 PCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNG-----GSCNPSPGGYYC 753
Query: 3586 SCEPA--SPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKA 3643
+C P+ P C + ++D C+SA C C + C+ RC+ K
Sbjct: 754 TCPPSHTGPQCQT-----STDYCVSAP--CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKL 806
Query: 3644 HCIPIRWLCDGIHDCVDGSDEENC----ERGGNICRADEFLCNNSLCKLHFWVCDGEDDC 3699
C C D C G C+ LC C + C
Sbjct: 807 RPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRN-------SHC 859
Query: 3700 GDNSDEAPDMCVKF----LCPSTRPHRCRNNRIC--LQSEQMCNGIDECGDNSDEDHCGG 3753
+C++ LC + C+ + + +C+ C D+ C
Sbjct: 860 LQTGPSFHCLCLQGWTGPLC-NLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHC 918
Query: 3754 KLTYKARPCKKDEFACSNKKC----IPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 3809
++ C+ C ++ C M L C G D Q C + C+
Sbjct: 919 PPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNC--SKELDACQSQ- 975
Query: 3810 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCE-DLNECL---VFGTCSHQCINVEGSY 3865
PC + C C C PGF +CE D++ECL T + C ++ ++
Sbjct: 976 -PCHNHGTCTPKPGGFHCACPPGF----VGLRCEGDVDECLDQPCHPTGTAACHSLANAF 1030
Query: 3866 KCVC 3869
C C
Sbjct: 1031 YCQC 1034
Score = 58.2 bits (139), Expect = 2e-07
Identities = 143/627 (22%), Positives = 199/627 (31%), Gaps = 162/627 (25%)
Query: 2459 DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFEC 2518
+TN C +PC L + CHDL NG C C RC C + C
Sbjct: 513 ETNECASAPC-LNHADCHDLL----NG-FQCICLPG---FSGTRCEEDIDECRSSP---C 560
Query: 2519 GNG-ECID----YQLTC----DGIPHCKDKSDEKL----------------LYCENRSCR 2553
NG +C D + C +G P C+ + DE L +C C
Sbjct: 561 ANGGQCQDQPGAFHCKCLPGFEG-PRCQTEVDECLSDPCPVGASCLDLPGAFFC---LCP 616
Query: 2554 RGF--KPCYNRRCIPHGKLCDGENDCGDNSDELDCKVST----CATVEFRCA--DGTCIP 2605
GF + C C P+ LC + C D D+ +C CA E C G C
Sbjct: 617 SGFTGQLCEVPLCAPN--LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR 674
Query: 2606 RSARCNQNIDCADASDEKN-CNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSND 2664
S C+ + E C + C H + +G+ C PT +
Sbjct: 675 SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYN-------CTCPTGYTGPT-- 725
Query: 2665 CGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQ 2724
C E +C SG C LN C+ G C S + Q
Sbjct: 726 -----------------CSEEMTACHSGPC-LNGGSCNPSP----GGYYCTCPPSHTGPQ 763
Query: 2725 FACSAQKCISKHWICDGEDDCGDGLDESDSIC----------GAITCAADMFSCQGSRAC 2774
S C+S C C + +C G + + C+ C
Sbjct: 764 CQTSTDYCVSAP--CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC 821
Query: 2775 VPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDD----- 2829
+D P G L G +C +C K C P+ C
Sbjct: 822 ----------QDSPQGPRCLCPTGYT-GGSCQTLMDLCAQKPC-PRNSHCLQTGPSFHCL 869
Query: 2830 CGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPD-------HSDEAPLNP 2882
C G P C ++ + + G ++ C C D H
Sbjct: 870 CLQGWT-GPLCNLPLSSCQKAALSQG---IDVSSLCHNGGLCVDSGPSYFCHCPPGFQGS 925
Query: 2883 KCKSAEQSCNSSFFMCKNGR-CI--PSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCS 2939
C+ C S C+NG C+ PSG LC C G D +NC SK++ C
Sbjct: 926 LCQDHVNPCESR--PCQNGATCMAQPSGYLCQ----CAPGYDGQNC------SKELDACQ 973
Query: 2940 QD-------CQDLPVSYKCKCWPGF-QLKDDGKTCVDIDECSSGFPC----SQQCINTYG 2987
C P + C C PGF L+ +G D+DEC PC + C +
Sbjct: 974 SQPCHNHGTCTPKPGGFHCACPPGFVGLRCEG----DVDECLDQ-PCHPTGTAACHSLAN 1028
Query: 2988 TYKCLCTDGY-------EIQPDNPNGC 3007
+ C C G+ EI P + C
Sbjct: 1029 AFYCQCLPGHTGQWCEVEIDPCHSQPC 1055
Score = 55.8 bits (133), Expect = 9e-07
Identities = 138/622 (22%), Positives = 186/622 (29%), Gaps = 189/622 (30%)
Query: 2466 SPCALLNGGCHDLCLLTPNGRVNCSC----RGDRILLEDNRCVTKNSSCNAYSEFECGNG 2521
SPC +GG CL TP G NC C G R + N C+++ C G
Sbjct: 444 SPCE--HGGS---CLNTP-GSFNCLCPPGYTGSRCEADHNECLSQ----------PCHPG 487
Query: 2522 E-CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN 2580
C+D T HC E + C C + C+ H DC D
Sbjct: 488 STCLDLLATF----HCLCPPG-----LEGQLCEVETNECASAPCLNHA-------DCHDL 531
Query: 2581 SDELDCKVSTCATVEFRCADGTCIP--RSARCNQNIDCADASDEKNCNNTDCTHFYKLGV 2638
+ C C+P RC ++ID
Sbjct: 532 LNGFQC---------------ICLPGFSGTRCEEDID----------------------- 553
Query: 2639 KTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC---PVQNKHKCEENYFSCPSGRCI 2695
C S+ C C D C P +C+ C S C
Sbjct: 554 ------ECRSSP--------CANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCP 599
Query: 2696 LNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI 2755
+ C D F C + C C +C + C D D+++ +
Sbjct: 600 VGA-------SCLDLPGAFFCLCPSGFTGQLCEVPLCAPN--LCQPKQICKDQKDKANCL 650
Query: 2756 C--GAITCAADMFSCQGSRA-CVPRHWLCDGERDCPDGSDELS---TAGCAPNNTC--DE 2807
C G+ CA +C C +CD P+ EL +A CA TC
Sbjct: 651 CPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQP 710
Query: 2808 NAFMCH------NKVCIPKQFVCDHDDDCGDGSDESPQCGYR-----------QCGTEEF 2850
+ + C C + C H C +G +P G QC T
Sbjct: 711 SGYNCTCPTGYTGPTCSEEMTAC-HSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTD 769
Query: 2851 SCADGRCLLN-TQWQCDGDFDC------PDHSDEAPLNPKCKSAEQSCNSSFFMCKNG-- 2901
C C T G F C E L P C A+ C + C++
Sbjct: 770 YCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSC--ADSPCRNRA-TCQDSPQ 826
Query: 2902 --RCIP----SGGLCDNKDD-CGDGSDERNCHINE--------CL--------SKKVSGC 2938
RC+ +GG C D C RN H + CL + +S C
Sbjct: 827 GPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSC 886
Query: 2939 SQD-----------------CQDLPVSYKCKCWPGFQLKDDGKTCVD-IDECSSGFPCSQ 2980
+ C D SY C C PGFQ G C D ++ C S PC
Sbjct: 887 QKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQ----GSLCQDHVNPCESR-PCQN 941
Query: 2981 --QCINTYGTYKCLCTDGYEIQ 3000
C+ Y C C GY+ Q
Sbjct: 942 GATCMAQPSGYLCQCAPGYDGQ 963
Score = 51.6 bits (122), Expect = 2e-05
Identities = 119/499 (23%), Positives = 159/499 (31%), Gaps = 146/499 (29%)
Query: 801 NNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNR----H 856
N G C + +C C + G C NP + H C+ G C++
Sbjct: 245 NGGTCQLMPEKDSTFHLCLCPPGFI----GPDCEVNPDNCVSHQCQNGG-TCQDGLDTYT 299
Query: 857 CIQAR----WKCDGD-DDCLDGSDEDSVNCFNHSCPDDQFKCQNN----RCI-PKRWLCD 906
C+ W C D D+C + +C N CQN+ C+ W
Sbjct: 300 CLCPETWTGWDCSEDVDEC---ETQGPPHCRNGGT------CQNSAGSFHCVCVSGW--- 347
Query: 907 GANDCGSNEDESNQTCTARTC--------QVDQFSCGNGRCIP--RAWLCDREDDCGDQT 956
G C N D+ C A TC +V FSC C P LC ED C Q
Sbjct: 348 GGTSCEENLDD----CIAATCAPGSTCIDRVGSFSC---LCPPGRTGLLCHLEDMCLSQP 400
Query: 957 DEM-ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH--SCFDN--QF 1011
A C T +C+ G H D D+ C H SC + F
Sbjct: 401 CHGDAQCSTNPLTGSTLCLCQPGYS-GPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSF 459
Query: 1012 RCSSGRCIPGHWA--CDGD-NDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVP 1068
C C PG+ C+ D N+C + P CHP C+
Sbjct: 460 NCL---CPPGYTGSRCEADHNEC---------------LSQP---------CHPGSTCLD 492
Query: 1069 DL--WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED-- 1124
L + C C G + + C C ++ C+N A DC D
Sbjct: 493 LLATFHCL----CPPGLEGQLCEVETNEC---------ASAPCLNHA-------DCHDLL 532
Query: 1125 ----------------QSDEDDCDSFLCGPPKHPCANDTSVCLQPEKL-CNGKKDCPDGS 1167
+ D D+C S PCAN QP C C G
Sbjct: 533 NGFQCICLPGFSGTRCEEDIDECRS-------SPCANGGQCQDQPGAFHCK----CLPGF 581
Query: 1168 DEGYLC----DECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK 1223
EG C DEC + C +PG C CP G + CE+ N +
Sbjct: 582 -EGPRCQTEVDECLSDPCPVGASCLDLPG-AFFCLCPSGFT----GQLCEVPLCAPNLCQ 635
Query: 1224 CSQVCEQHKHTVKCSCYEG 1242
Q+C+ K C C +G
Sbjct: 636 PKQICKDQKDKANCLCPDG 654
Score = 50.8 bits (120), Expect = 3e-05
Identities = 107/475 (22%), Positives = 165/475 (34%), Gaps = 103/475 (21%)
Query: 794 GDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCK 853
GD C N STLCL PG +G TC + E L + + G C+
Sbjct: 403 GDAQCSTNPLTGSTLCLCQPG-------------YSGPTCHQDLDECL--MAQQGPSPCE 447
Query: 854 NRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCP----DDQFKCQNNRCIPKRWLCDGAN 909
+ GS ++ FN CP + + +N C+ + C +
Sbjct: 448 H-----------------GGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQP--CHPGS 488
Query: 910 DCGSNEDESNQTC----TARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFP 965
C + C + C+V+ C + C+ A DC D +
Sbjct: 489 TCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHA-------DCHDLLNGF------ 535
Query: 966 TCEPLTQFVCKSGRCISSKWHCDSD-DDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWA 1024
Q +C G S C+ D D+C G F C +C+PG
Sbjct: 536 ------QCICLPG---FSGTRCEEDIDECRSSPCANGGQCQDQPGAFHC---KCLPGFEG 583
Query: 1025 --CDGD-NDCGDFSDEAQINCTKEEIHSPAGC---NGNEFQCHPDGNCVPDLWRCDGEKD 1078
C + ++C SD + + ++ C +G Q C P+L C ++
Sbjct: 584 PRCQTEVDEC--LSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNL--CQPKQI 639
Query: 1079 CEDGSDEKGC---NGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFL 1135
C+D D+ C +G+ + +C G C + VCD +C++ L
Sbjct: 640 CKDQKDKANCLCPDGSPGCAPPEDNCTC-HHGHCQRSSCVCDVG------WTGPECEAEL 692
Query: 1136 CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDE--CSLNNGGCSN--HCSVVP 1191
G PCA+ + QP CP G G C E + ++G C N C+ P
Sbjct: 693 GGCISAPCAHGGTCYPQPS---GYNCTCPTGY-TGPTCSEEMTACHSGPCLNGGSCNPSP 748
Query: 1192 GRGIVCSCPEGLQLNKDNKTCEI-VDYC-SNHLKCSQVCEQHKHTVKCSCYEGWK 1244
G G C+CP + C+ DYC S C T C C G++
Sbjct: 749 G-GYYCTCPP----SHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQ 798
Score = 48.9 bits (115), Expect = 1e-04
Identities = 144/670 (21%), Positives = 211/670 (31%), Gaps = 207/670 (30%)
Query: 2459 DTNSCELSPCALLNGG-CHDLCLLTPNGRVNCSC----RGDRILLEDNRCVTK----NSS 2509
D + C SPCA NGG C D G +C C G R E + C++ +S
Sbjct: 551 DIDECRSSPCA--NGGQCQD-----QPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGAS 603
Query: 2510 C-NAYSEFEC-----GNGECIDYQLT----CDGIPHCKDKSDEKLLYCENRSCRRGFKP- 2558
C + F C G+ + L C CKD+ D+ C + S G P
Sbjct: 604 CLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGS--PGCAPP 661
Query: 2559 -----CYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADG-TCIPRSA---- 2608
C++ C +CD G E + ++ C + CA G TC P+ +
Sbjct: 662 EDNCTCHHGHCQRSSCVCD----VGWTGPECEAELGGCISAP--CAHGGTCYPQPSGYNC 715
Query: 2609 ---------RCNQNIDCADASDEKN---CNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPT 2656
C++ + + N CN + ++ TG ST CV
Sbjct: 716 TCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAP 775
Query: 2657 WICDGSNDCGDYSDELKC----------------------PVQNKHKCEENYFSCPSG-R 2693
C C + C P +N+ C+++ P G R
Sbjct: 776 --CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDS----PQGPR 829
Query: 2694 CILNTWICDG----------QKDCEDGRD------EFHCDSSCSWNQFAC-----SAQKC 2732
C+ T G QK C FHC W C S QK
Sbjct: 830 CLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKA 889
Query: 2733 -----ISKHWICDGEDDCGDGLDE---------SDSICGAITCAADMFSCQGSRACV--P 2776
I +C C D S+C + CQ C+ P
Sbjct: 890 ALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQP 949
Query: 2777 RHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDE 2836
+LC C G D C + C ++ C + C
Sbjct: 950 SGYLCQ----CAPGYD---------GQNCSKELDACQSQPC-------HNHGTC------ 983
Query: 2837 SPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFD-CPDHSDEAPLNPKCKSAEQSCNSSF 2895
+P+ G C +C G L +C+GD D C D P +P +A S ++F
Sbjct: 984 TPKPGGFHC-----ACPPGFVGL----RCEGDVDECLDQ----PCHPTGTAACHSLANAF 1030
Query: 2896 FMCKNGRCIP--SGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKC 2953
+ +C+P +G C+ + D CH C G + P+ + C C
Sbjct: 1031 YC----QCLPGHTGQWCEVEID--------PCHSQPCFH---GGTCEATAGSPLGFICHC 1075
Query: 2954 WPGFQLKDDGKTC----------------VDIDECSSGFPCSQQCINTYGTYKCLCTDGY 2997
GF+ G TC + + GFP C++ YG CL
Sbjct: 1076 PKGFE----GPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCL----- 1126
Query: 2998 EIQPDNPNGC 3007
P P GC
Sbjct: 1127 --TPPAPKGC 1134
Score = 44.3 bits (103), Expect = 0.003
Identities = 54/211 (25%), Positives = 73/211 (34%), Gaps = 66/211 (31%)
Query: 31 LCDPGE--FLCHDHVTCVSQSWLCDGD----------------------PDCPDDSDESL 66
LC PG LCH C+SQ C GD P C D DE L
Sbjct: 380 LCPPGRTGLLCHLEDMCLSQP--CHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECL 437
Query: 67 ------------DTC------------PEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLD 102
+C P +C +H CL ++ H C +L
Sbjct: 438 MAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECL--SQPCHPGSTCLDLLA 495
Query: 103 -----CPDGYDEGVHCQELLSNCQQLNC--QYKCTMVRNSTRCYCEDGFEITEDGRSCKD 155
CP G EG C+ + C C C + N +C C GF T R +D
Sbjct: 496 TFHCLCPPGL-EGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGT---RCEED 551
Query: 156 QDECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
DEC C+ C++ G++ C C+ G+
Sbjct: 552 IDECRS-SPCANGGQCQDQPGAFHCKCLPGF 581
Score = 43.5 bits (101), Expect = 0.005
Identities = 40/134 (29%), Positives = 53/134 (39%), Gaps = 19/134 (14%)
Query: 2888 EQSCNSSFFMCKNGRC-IPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLP 2946
E C SF K GRC I + G + C G C + + S C
Sbjct: 119 EDPCPPSF-CSKRGRCHIQASGR--PQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATY 175
Query: 2947 VSYKCKCWPGFQLKDDGKTCV-DIDEC-SSGFPCSQ--QCINTYGTYKCLCTDGYE---- 2998
+C C PGF+ G C D++EC PC + C NT G+++CLC G E
Sbjct: 176 PQIQCHCPPGFE----GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRC 231
Query: 2999 ---IQPDNPNGCKS 3009
P P GC +
Sbjct: 232 ELRAGPCPPRGCSN 245
Score = 41.6 bits (96), Expect = 0.018
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 20/123 (16%)
Query: 78 PLNHIACLGTNKCVHLSQLC-NGVL----------DCPDGYDEGVHCQELLSNCQQLNCQ 126
PL+ ++ + +S LC NG L CP G+ +G CQ+ ++ C+ CQ
Sbjct: 882 PLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGF-QGSLCQDHVNPCESRPCQ 940
Query: 127 YKCTMVRNSTR--CYCEDGFEITEDGRSCKDQDECAVYGTCSQ--TCRNTHGSYTCSCVE 182
T + + C C G+ DG++C + + C TC G + C+C
Sbjct: 941 NGATCMAQPSGYLCQCAPGY----DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPP 996
Query: 183 GYL 185
G++
Sbjct: 997 GFV 999
Score = 41.2 bits (95), Expect = 0.024
Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 12/89 (13%)
Query: 103 CPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSC-KDQDEC 159
CP G+ G C+ NC CQ C ++ C C + T G C +D DEC
Sbjct: 264 CPPGFI-GPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPE----TWTGWDCSEDVDEC 318
Query: 160 AVYGT--CSQ--TCRNTHGSYTCSCVEGY 184
G C TC+N+ GS+ C CV G+
Sbjct: 319 ETQGPPHCRNGGTCQNSAGSFHCVCVSGW 347
Score = 40.8 bits (94), Expect = 0.031
Identities = 88/365 (24%), Positives = 116/365 (31%), Gaps = 95/365 (26%)
Query: 809 CLAIPGGRVCACA---DNQLLDENGTTCTFNP----GEALPHICKAGEFRCKNRHCIQAR 861
C+A P G +C CA D Q + C P G P K G F C
Sbjct: 945 CMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTP---KPGGFHCACPPGF-VG 1000
Query: 862 WKCDGD-DDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQ 920
+C+GD D+CLD + HS + F CQ C+P
Sbjct: 1001 LRCEGDVDECLDQPCHPTGTAACHSLA-NAFYCQ---CLPGH------------------ 1038
Query: 921 TCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASC----EFPTCEPLTQFVCK 976
T + C+V+ C + C C E G + C E PTC
Sbjct: 1039 --TGQWCEVEIDPCHSQPCF-HGGTC--EATAGSPLGFICHCPKGFEGPTC--------- 1084
Query: 977 SGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSD 1036
S R S +H C G + F + C SG P CG S
Sbjct: 1085 SHRAPSCGFH-----HCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSP 1139
Query: 1037 EAQINCTKEEIHSPAGCNGNEFQCH-PDGNCVPDLWRCD--GEKDCE----DGSDEKGCN 1089
E G G F+C P + P RC G K CE DG+ + GC+
Sbjct: 1140 CLYNGSCSE----TTGLGGPGFRCSCPHSSPGP---RCQKPGAKGCEGRSGDGACDAGCS 1192
Query: 1090 GTIRLCDHKTKFSCWSTGRCI-------------NKAWVCDGDIDCEDQSDEDDC--DSF 1134
G W G C ++ W+ D C Q D ++C D +
Sbjct: 1193 G---------PGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGY 1243
Query: 1135 LCGPP 1139
C P
Sbjct: 1244 DCETP 1248
Score = 39.3 bits (90), Expect = 0.091
Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 15/123 (12%)
Query: 67 DTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQ 126
+ C ++E CP + C +C H+ C G+ G CQ L C C
Sbjct: 112 ERCQAKLEDPCPPSF--CSKRGRC-HIQASGRPQCSCMPGWT-GEQCQ-LRDFCSANPCV 166
Query: 127 YK--CTMVRNSTRCYCEDGFEITEDGRSC-KDQDECAVY-GTCSQ--TCRNTHGSYTCSC 180
C +C+C GFE G +C +D +EC G C + +C NT GS+ C C
Sbjct: 167 NGGVCLATYPQIQCHCPPGFE----GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLC 222
Query: 181 VEG 183
G
Sbjct: 223 PVG 225
Score = 39.3 bits (90), Expect = 0.091
Identities = 43/172 (25%), Positives = 61/172 (35%), Gaps = 52/172 (30%)
Query: 42 HVTCVSQSWLCDGDPDCPDDSDESL-------DTCPEEV---EIKCPLNHIACLGTNKCV 91
H CVS W G C ++ D+ + TC + V CP L + +
Sbjct: 340 HCVCVS-GW---GGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM 395
Query: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
LSQ C+G C + ST C C+ G+ G
Sbjct: 396 CLSQPCHGDAQC------------------------STNPLTGSTLCLCQPGYS----GP 427
Query: 152 SC-KDQDECAVY----GTCSQ--TCRNTHGSYTCSCVEGYL---MQPDNRSC 193
+C +D DEC + C +C NT GS+ C C GY + D+ C
Sbjct: 428 TCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC 479
Score = 37.7 bits (86), Expect = 0.27
Identities = 47/194 (24%), Positives = 64/194 (32%), Gaps = 36/194 (18%)
Query: 31 LCDPGEFLCHDHVTCVSQ----SWLC-DGDPDCPDDSDESL--------DTCPEEVEI-- 75
LC P LC C Q + LC DG P C D +C +V
Sbjct: 628 LCAPN--LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTG 685
Query: 76 -KCPLNHIACLGTNKCVH----LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQY--K 128
+C C+ C H Q CP GY G C E ++ C C
Sbjct: 686 PECEAELGGCISA-PCAHGGTCYPQPSGYNCTCPTGYT-GPTCSEEMTACHSGPCLNGGS 743
Query: 129 CTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQ--TCRNTHGSYTCSCVEGYLM 186
C C C + G C+ + V C TC N G+++C C G+
Sbjct: 744 CNPSPGGYYCTCPP----SHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGF-- 797
Query: 187 QPDNRSCKAKIEPT 200
C+ K+ P+
Sbjct: 798 --QGPRCEGKLRPS 809
Score = 37.4 bits (85), Expect = 0.35
Identities = 36/131 (27%), Positives = 48/131 (36%), Gaps = 29/131 (22%)
Query: 1137 GP-PKHPCANDTSVCLQPEK-----LCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVV 1190
GP P C+N + L PEK LC CP G ++ +C +N C +H
Sbjct: 236 GPCPPRGCSNGGTCQLMPEKDSTFHLCL----CPPG----FIGPDCEVNPDNCVSHQCQN 287
Query: 1191 PGR------GIVCSCPE---GLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYE 1241
G C CPE G ++D CE H + C+ + C C
Sbjct: 288 GGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQG--PPHCRNGGTCQNSAGSFHCVCVS 345
Query: 1242 GWKLDVDGESC 1252
GW G SC
Sbjct: 346 GW----GGTSC 352
Score = 35.8 bits (81), Expect = 1.0
Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 9/112 (8%)
Query: 3462 CADASDEANCDKKTCGPHEFQCKNNNC---IPDHWR-CDSQNDCSDNSDEENCKPQTCTL 3517
C S + CD GP +C +PD W+ C S + C + C PQ C
Sbjct: 1178 CEGRSGDGACDAGCSGPGG-NWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQ-CDS 1235
Query: 3518 KDFLCANGDCVSSRFWCDGDFD--CADGSDERNCETSCSKDQFRCSNGQCIP 3567
++ L DC + C +D C D +CE C+ + G C P
Sbjct: 1236 EECLFDGYDCETPPA-CTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRP 1286
Score = 35.0 bits (79), Expect = 1.7
Identities = 48/208 (23%), Positives = 62/208 (29%), Gaps = 54/208 (25%)
Query: 34 PGEFLCHDHVTCVS--QSWLCDGD--PDCPDDSDESLDTC---PEEVEIKCPLNHIACLG 86
PG F C C Q C+G P C D + TC P+ CP +
Sbjct: 786 PGTFSC----LCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTG--- 838
Query: 87 TNKCVHLSQLCNGVLDCPDGYD----------------EGVHCQELLSNCQQLNCQYK-- 128
C L LC CP G C LS+CQ+
Sbjct: 839 -GSCQTLMDLC-AQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGID 896
Query: 129 ----------CTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQ--TCRNTHGSY 176
C S C+C GF+ G C+D C TC Y
Sbjct: 897 VSSLCHNGGLCVDSGPSYFCHCPPGFQ----GSLCQDHVNPCESRPCQNGATCMAQPSGY 952
Query: 177 TCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
C C GY D ++C +++ P
Sbjct: 953 LCQCAPGY----DGQNCSKELDACQSQP 976
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 120 bits (300), Expect = 4e-26
Identities = 80/229 (34%), Positives = 102/229 (44%), Gaps = 25/229 (10%)
Query: 4221 CENGGRCILNEKGDLRCHCWPSYSGERCEVNH-CS-NYCQNGGTCVP-SVLGRPTCSCAL 4277
C N G C+ G C C + GE C+ C N CQNGGTCV ++LG+ TC CA
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94
Query: 4278 GFTGPNCGKTVCEDF-----CQNGGTCIVTAGNQPYCHCQPEYTGDRCQY--YVCHHYCV 4330
GFTG +C + C NGGTC + + + C CQ +TG CQ+ H C
Sbjct: 95 GFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCA 154
Query: 4331 NSESCTIGDDGSVECVCPTRYEGPKCEVD--KC---VRC-HGGHCIINKDSEDIFCNCTN 4384
N +CT + C C T + G KCE D +C C HGG C+ S C C
Sbjct: 155 NGSTCTTVAN-QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQ--CQCPQ 211
Query: 4385 GKIASSCQ-----LCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCER 4428
G C C NGGTC+ + C C + G+ CER
Sbjct: 212 GFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFE-CNCLPGFEGSTCER 259
Score = 113 bits (282), Expect = 5e-24
Identities = 85/284 (29%), Positives = 119/284 (41%), Gaps = 42/284 (14%)
Query: 4172 LPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNE 4231
+ PC++ LC C CP G C +D +DD C+NGG C ++
Sbjct: 878 ISKPCMNHG---LCHNTQGSYMCECPPG--FSGMDCEED--IDDCLANPCQNGGSC-MDG 929
Query: 4232 KGDLRCHCWPSYSGERCE--VNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV 4288
C C P ++G++C+ +N C S C+NGGTC V TC C GF G +C +
Sbjct: 930 VNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYV-NSYTCKCQAGFDGVHCENNI 988
Query: 4289 ---CEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV---CHHYCVNSESCTIGDDGS 4342
E C NGGTC V N C C +TG C + + H C+N +C G G+
Sbjct: 989 NECTESSCFNGGTC-VDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDG-LGT 1046
Query: 4343 VECVCPTRYEGPKCE--VDKCVR--CHGGHCIINKDSEDIFCNCTNGKIASSCQ------ 4392
C CP Y G C+ V+ C R C + K +E C C +G + C
Sbjct: 1047 YRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAES-QCLCPSGWAGAYCDVPNVSC 1105
Query: 4393 ---------LCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
L + C + G C N C C ++G+ CE
Sbjct: 1106 DIAASRRGVLVEHLCQHSGVC--INAGNTHYCQCPLGYTGSYCE 1147
Score = 111 bits (278), Expect = 1e-23
Identities = 93/291 (31%), Positives = 125/291 (42%), Gaps = 46/291 (15%)
Query: 4164 SHRYKQLDLPNPCLDLACEFLCLLNPSGAT-CVCPEGKYLINGTCNDDSLLDDSC-KLTC 4221
+H + D PC++ E +C+ +G C CPEG + C D C K C
Sbjct: 23 AHALQCRDGYEPCVN---EGMCVTYHNGTGYCKCPEG--FLGEYCQHR----DPCEKNRC 73
Query: 4222 ENGGRCILNEK-GDLRCHCWPSYSGERCEVN-----HCSNYCQNGGTCVPSVLGRPT--C 4273
+NGG C+ G C C ++GE C+ + S C NGGTC +L R T C
Sbjct: 74 QNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC--HMLSRDTYEC 131
Query: 4274 SCALGFTGPNCGKT-VCEDF-CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV----CHH 4327
+C +GFTG C T C C NG TC T NQ C C +TG +C+ V
Sbjct: 132 TCQVGFTGKECQWTDACLSHPCANGSTC-TTVANQFSCKCLTGFTGQKCETDVNECDIPG 190
Query: 4328 YCVNSESCTIGDDGSVECVCPTRYEGPKCE-------VDKCVRCHGGHCIINKDSEDIFC 4380
+C + +C + GS +C CP + G C+ CV +GG C D C
Sbjct: 191 HCQHGGTC-LNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV--NGGTCRQTGDF-TFEC 246
Query: 4381 NCTNGKIASSCQL----CDGY-CYNGGTCQLDPETNVPVCLCSTNWSGTQC 4426
NC G S+C+ C + C NGG C N C C W+G C
Sbjct: 247 NCLPGFEGSTCERNIDDCPNHRCQNGGVCV--DGVNTYNCRCPPQWTGQFC 295
Score = 103 bits (258), Expect = 3e-21
Identities = 81/267 (30%), Positives = 117/267 (43%), Gaps = 40/267 (14%)
Query: 4185 CLLNPSGATCVCPEGKYLINGTCNDDSLLDDSC-KLTCENGGRCILNE-KGDLRCHCWPS 4242
C+ + +C+CPEGK + C+ LDD+C C G C N G C C
Sbjct: 353 CIDRVASFSCMCPEGKAGL--LCH----LDDACISNPCHKGALCDTNPLNGQYICTCPQG 406
Query: 4243 YSGERC--EVNHC----SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE---DFC 4293
Y G C +V+ C SN C++ G CV + G C C G+ GP C + E D C
Sbjct: 407 YKGADCTEDVDECAMANSNPCEHAGKCV-NTDGAFHCECLKGYAGPRCEMDINECHSDPC 465
Query: 4294 QNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CH-HYCVNSESCTIGDDGSVECVCPTR 4350
QN TC+ G C C P + G C+ + C + CVN+ C + +C+CP
Sbjct: 466 QNDATCLDKIGGFT-CLCMPGFKGVHCELEINECQSNPCVNNGQC-VDKVNRFQCLCPPG 523
Query: 4351 YEGPKCEVD----KCVRC-HGGHCIINKDSEDIFCNCTNGKIASSCQ----LCDGYCYNG 4401
+ GP C++D C +G CI + + + C C G C+ CD +
Sbjct: 524 FTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYE--CQCATGFTGVLCEENIDNCDPDPCHH 581
Query: 4402 GTCQ--LDPETNVPVCLCSTNWSGTQC 4426
G CQ +D T C+C+ + G C
Sbjct: 582 GQCQDGIDSYT----CICNPGYMGAIC 604
Score = 100 bits (250), Expect = 3e-20
Identities = 84/282 (29%), Positives = 108/282 (38%), Gaps = 35/282 (12%)
Query: 4169 QLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCI 4228
+ D+P C CL P C CP+G C DSL C NGG C
Sbjct: 185 ECDIPGHCQHGGT---CLNLPGSYQCQCPQG--FTGQYC--DSLYVPCAPSPCVNGGTCR 237
Query: 4229 LNEKGDLRCHCWPSYSGERCE--VNHCSNY-CQNGGTCVPSVLGRPTCSCALGFTGPNCG 4285
C+C P + G CE ++ C N+ CQNGG CV V C C +TG C
Sbjct: 238 QTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGV-NTYNCRCPPQWTGQFCT 296
Query: 4286 KTVCE-----DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CHHYCVNSESCTIG 4338
+ V E + CQNGGTC G C C ++GD C + C S I
Sbjct: 297 EDVDECLLQPNACQNGGTCANRNGGYG-CVCVNGWSGDDCSENIDDCAFASCTPGSTCID 355
Query: 4339 DDGSVECVCPTRYEGPKCEV-DKCVR--CH-GGHCIINKDSEDIFCNCTNGKIASSC--- 4391
S C+CP G C + D C+ CH G C N + C C G + C
Sbjct: 356 RVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED 415
Query: 4392 -----QLCDGYCYNGGTC-QLDPETNVPVCLCSTNWSGTQCE 4427
C + G C D + C C ++G +CE
Sbjct: 416 VDECAMANSNPCEHAGKCVNTDGAFH---CECLKGYAGPRCE 454
Score = 96.3 bits (238), Expect = 6e-19
Identities = 87/296 (29%), Positives = 121/296 (40%), Gaps = 43/296 (14%)
Query: 4174 NPCLDLACEF--LCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNE 4231
N CL C+ C + TC C G ++ C ++ +++ + +C NGG C+ +
Sbjct: 951 NECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVH--CENN--INECTESSCFNGGTCV-DG 1005
Query: 4232 KGDLRCHCWPSYSGERC--EVNHCSNY-CQNGGTCVPSVLGRPTCSCALGFTGPNCGKTV 4288
C C ++G C E+N CS++ C N GTCV LG CSC LG+TG NC V
Sbjct: 1006 INSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDG-LGTYRCSCPLGYTGKNCQTLV 1064
Query: 4289 ---CEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQY-------------YVCHHYCVNS 4332
C+N GTC+ + C C + G C + H C +S
Sbjct: 1065 NLCSRSPCKNKGTCVQKKA-ESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHS 1123
Query: 4333 ESCTIGDDGSVECVCPTRYEGPKCE--VDKCVR--C-HGGHCIINKDSEDIFCNCTNGKI 4387
C I + C CP Y G CE +D+C C HG C + C C G
Sbjct: 1124 GVC-INAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATC--SDFIGGYRCECVPGYQ 1180
Query: 4388 ASSCQL----CDGY-CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDH 4438
+C+ C C NGGTC +D N C C G CE ++ H
Sbjct: 1181 GVNCEYEVDECQNQPCQNGGTC-ID-LVNHFKCSCPPGTRGLLCEENIDDCARGPH 1234
Score = 95.1 bits (235), Expect = 1e-18
Identities = 89/320 (27%), Positives = 128/320 (40%), Gaps = 84/320 (26%)
Query: 4174 NPCLDLACEFLCLLNPSGATCVCP---EGKYLINGTCNDDSLLDDSCKLTCENGGRCILN 4230
NPCL+ + C + SG TC C GK N ++L CEN C +
Sbjct: 802 NPCLN---QGTCFDDISGYTCHCVLPYTGK-------NCQTVLAPCSPNPCENAAVCKES 851
Query: 4231 EKGD-LRCHCWPSYSGERC--EVNHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGK 4286
+ C C P + G+RC +++ C S C N G C + G C C GF+G +C +
Sbjct: 852 PNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLC-HNTQGSYMCECPPGFSGMDCEE 910
Query: 4287 TVCE---DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQ---------------------- 4321
+ + + CQNGG+C + N C C P +TGD+CQ
Sbjct: 911 DIDDCLANPCQNGGSC-MDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969
Query: 4322 YYVC-------------------HHYCVNSESCTIGDDGSVECVCPTRYEGPKC--EVDK 4360
Y C C N +C G + S C+CP + G C E+++
Sbjct: 970 SYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGIN-SFSCLCPVGFTGSFCLHEINE 1028
Query: 4361 CVRCHGGHCIINKDS-----EDIFCNCTNGKIASSCQ----LCD-GYCYNGGTC-QLDPE 4409
C H +N+ + C+C G +CQ LC C N GTC Q E
Sbjct: 1029 C----SSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAE 1084
Query: 4410 TNVPVCLCSTNWSGTQCERP 4429
+ CLC + W+G C+ P
Sbjct: 1085 SQ---CLCPSGWAGAYCDVP 1101
Score = 92.0 bits (227), Expect = 1e-17
Identities = 90/321 (28%), Positives = 126/321 (39%), Gaps = 68/321 (21%)
Query: 4160 GVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKL 4219
GVL D P+PC C+ TC+C G + C+D +D+
Sbjct: 564 GVLCEENIDNCD-PDPCHHGQCQD----GIDSYTCICNPG--YMGAICSDQ--IDECYSS 614
Query: 4220 TCENGGRCILNEKGDLRCHCWPSYSGERCEVNH---CSNYCQNGGTCVPSVLGRPTCSCA 4276
C N GRCI G +C+C P SG CE+N SN C +G C+ + R +C C+
Sbjct: 615 PCLNDGRCIDLVNG-YQCNCQPGTSGVNCEINFDDCASNPCIHG-ICMDGI-NRYSCVCS 671
Query: 4277 LGFTGPNCGKTVCE---DFCQNGGTCIVTA-GNQPYCHCQPEYTGDRCQYYVC-HHYCVN 4331
GFTG C + E + C+ G TCI G + C P + Q C + C++
Sbjct: 672 PGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIH 731
Query: 4332 SESCTIGDDGSVECVCPTRYEGPKCEVDK--CV-----------------RC------HG 4366
+CT G G +C+C + G CEVDK C+ RC G
Sbjct: 732 G-NCTGGLSG-YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Query: 4367 GHCIINKDS-------------EDIF---CNCTNGKIASSCQLC-----DGYCYNGGTCQ 4405
+C +N D +DI C+C +CQ C N C+
Sbjct: 790 YNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCK 849
Query: 4406 LDPETNVPVCLCSTNWSGTQC 4426
P CLC+ W G +C
Sbjct: 850 ESPNFESYTCLCAPGWQGQRC 870
Score = 86.7 bits (213), Expect = 5e-16
Identities = 83/324 (25%), Positives = 114/324 (35%), Gaps = 89/324 (27%)
Query: 4173 PNPCL---------DLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCEN 4223
P+PC+ D E CL G+TC + +DD C+N
Sbjct: 227 PSPCVNGGTCRQTGDFTFECNCLPGFEGSTC---------------ERNIDDCPNHRCQN 271
Query: 4224 GGRCILNEKGDLRCHCWPSYSGERC--EVNHC---SNYCQNGGTCVPSVLGRPTCSCALG 4278
GG C+ + C C P ++G+ C +V+ C N CQNGGTC + G C C G
Sbjct: 272 GGVCV-DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCA-NRNGGYGCVCVNG 329
Query: 4279 FTGPNCGKTVCE---DFCQNGGTCIVTAGN------------------------------ 4305
++G +C + + + C G TCI +
Sbjct: 330 WSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGAL 389
Query: 4306 --------QPYCHCQPEYTGDRCQYYVCHHYCVNSESCT-----IGDDGSVECVCPTRYE 4352
Q C C Y G C V NS C + DG+ C C Y
Sbjct: 390 CDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA 449
Query: 4353 GPKCEVDKCVRCHGGHCIINKDSED----IFCNCTNGKIASSCQL----CDGY-CYNGGT 4403
GP+CE+D CH C + D C C G C+L C C N G
Sbjct: 450 GPRCEMD-INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQ 508
Query: 4404 CQLDPETNVPVCLCSTNWSGTQCE 4427
C + N CLC ++G C+
Sbjct: 509 CV--DKVNRFQCLCPPGFTGPVCQ 530
Score = 83.6 bits (205), Expect = 4e-15
Identities = 77/276 (27%), Positives = 105/276 (38%), Gaps = 43/276 (15%)
Query: 4174 NPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKG 4233
NPC++ C+ + C+CP G C D +DD C NG +CI + G
Sbjct: 501 NPCVNNG---QCVDKVNRFQCLCPPG--FTGPVCQID--IDDCSSTPCLNGAKCIDHPNG 553
Query: 4234 DLRCHCWPSYSGERCEVN--HCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCED 4291
C C ++G CE N +C + G C + TC C G+ G C + E
Sbjct: 554 -YECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGI-DSYTCICNPGYMGAICSDQIDEC 611
Query: 4292 F---CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCT-------IGDDG 4341
+ C N G CI N C+CQP +G C+ +N + C I DG
Sbjct: 612 YSSPCLNDGRCIDLV-NGYQCNCQPGTSGVNCE--------INFDDCASNPCIHGICMDG 662
Query: 4342 --SVECVCPTRYEGPKC--EVDKCVR--CHGGHCIINKDSEDIFCNCTNGKIASSCQLCD 4395
CVC + G +C ++D+C C G IN C C G SC
Sbjct: 663 INRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCIN-GVNGFRCICPEGPHHPSCYSQV 721
Query: 4396 GYCYNG----GTCQLDPETNVPVCLCSTNWSGTQCE 4427
C + G C + CLC W G CE
Sbjct: 722 NECLSNPCIHGNCT--GGLSGYKCLCDAGWVGINCE 755
Score = 82.4 bits (202), Expect = 9e-15
Identities = 125/491 (25%), Positives = 180/491 (36%), Gaps = 104/491 (21%)
Query: 2551 SCRRGF--KPC-YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRS 2607
+C+ GF K C + C+ H C + C +++ CK T T + D
Sbjct: 132 TCQVGFTGKECQWTDACLSHP--CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIP 189
Query: 2608 ARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSN--DC 2665
C C + C C + TG C+S + P+ +G
Sbjct: 190 GHCQHGGTCLNLPGSYQCQ---CPQGF------TGQY-CDSLYVPCAPSPCVNGGTCRQT 239
Query: 2666 GDYSDELKC-PVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQ 2724
GD++ E C P CE N CP+ RC C DG + ++C W
Sbjct: 240 GDFTFECNCLPGFEGSTCERNIDDCPNHRC-------QNGGVCVDGVNTYNCRCPPQWTG 292
Query: 2725 FACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACV-PRHWLCDG 2783
C+ +D + L + ++ TCA + G CV W D
Sbjct: 293 QFCT--------------EDVDECLLQPNACQNGGTCA----NRNGGYGCVCVNGWSGD- 333
Query: 2784 ERDCPDGSDELSTAGCAPNNTCDEN-------------AFMCH-NKVCIP----KQFVCD 2825
DC + D+ + A C P +TC + +CH + CI K +CD
Sbjct: 334 --DCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCD 391
Query: 2826 HDDDCGDGSDESPQCGYR--QCGTEEFSCA---------DGRCLLNTQWQCDGDFDCPDH 2874
+ G PQ GY+ C + CA G+C +NT DG F C
Sbjct: 392 TNPLNGQYICTCPQ-GYKGADCTEDVDECAMANSNPCEHAGKC-VNT----DGAFHCECL 445
Query: 2875 SDEAPLNPKCKSAEQSCNSSFFMCKN-GRCIP--SGGLCDNKDDCGDGSDERNC--HINE 2929
A P+C+ C+S C+N C+ G C C G +C INE
Sbjct: 446 KGYA--GPRCEMDINECHSD--PCQNDATCLDKIGGFTC----LCMPGFKGVHCELEINE 497
Query: 2930 CLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGFPC--SQQCINTY 2986
C S Q C D ++C C PGF G C +DID+CSS PC +CI+
Sbjct: 498 CQSNPCVNNGQ-CVDKVNRFQCLCPPGF----TGPVCQIDIDDCSS-TPCLNGAKCIDHP 551
Query: 2987 GTYKCLCTDGY 2997
Y+C C G+
Sbjct: 552 NGYECQCATGF 562
Score = 80.9 bits (198), Expect = 3e-14
Identities = 178/777 (22%), Positives = 256/777 (32%), Gaps = 225/777 (28%)
Query: 3282 GGCSH--LCLLAPGKTHTCACPTNF--------YLAADNRTCLSNCTASQFRCKTDKCIP 3331
G C H CL PG ++ C CP F Y+ C++ T Q T +C
Sbjct: 190 GHCQHGGTCLNLPG-SYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFEC-- 246
Query: 3332 FWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGEND---------- 3381
C + DDCP RCQ G G+C DG N
Sbjct: 247 ---NCLPGFEGSTCERNIDDCPNHRCQNG------GVCV------DGVNTYNCRCPPQWT 291
Query: 3382 ---CGDNSDELNCDTHVCLSGQFKCTKN--QKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
C ++ DE + C +G +N C+ VN DDC + D DC SC
Sbjct: 292 GQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSG--DDCSENID--DCAFASC 347
Query: 3437 SPDY-------------------FQCKTTKHCIS----KLWVCDEDP------------- 3460
+P C CIS K +CD +P
Sbjct: 348 TPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGY 407
Query: 3461 ---DCADASDEANCDKKTCGPHEFQCKNNN---------------CIPDHWRCDS---QN 3499
DC + DE H +C N + C D C S QN
Sbjct: 408 KGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQN 467
Query: 3500 D--CSDNSDEENC------KPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC-- 3549
D C D C K C L+ C + CV++ C D + C
Sbjct: 468 DATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNG-------QCVDKVNRFQCLC 520
Query: 3550 -----ETSCSKDQFRCSNGQCIPAKWKCDGHED-----CKYGEDEKSCEPASPTCSSR-- 3597
C D CS+ C+ KC H + C G CE C
Sbjct: 521 PPGFTGPVCQIDIDDCSSTPCLNGA-KCIDHPNGYECQCATGFTGVLCEENIDNCDPDPC 579
Query: 3598 EYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIH- 3656
+ DG S + CN Y A SD++D EC C N CI L +G
Sbjct: 580 HHGQCQDGIDSYTCICNPGYMGAICSDQID---ECYSSP--CLNDGRCID---LVNGYQC 631
Query: 3657 DCVDGSDEENCERGGNICRADEFLCNNSLC----KLHFWVCD----GE------DDCGDN 3702
+C G+ NCE + C ++ C + +C + VC G+ D+C N
Sbjct: 632 NCQPGTSGVNCEINFDDCASNP--CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASN 689
Query: 3703 SDEAPDMCV------KFLCPSTRPHRCRNNRI--CLQSEQM---CNG------------- 3738
C+ + +CP H +++ CL + + C G
Sbjct: 690 PCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGW 749
Query: 3739 --------IDECGDNSDED-----------HCGGKLTYKARPCKKDEFACSNKKCIPMDL 3779
+EC N ++ C K +K C+ + C++ C+
Sbjct: 750 VGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLN--- 806
Query: 3780 QCDRLDDCGDGSDEQGCRIAPTEYTCED-----NVNPCGDDAYCNQIKT--SVFCRCKPG 3832
Q DD + C + T C+ + NPC + A C + S C C PG
Sbjct: 807 QGTCFDDISGYTCH--CVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPG 864
Query: 3833 FQRNMKNRQCE-DLNECLVFGTCSH-QCINVEGSYKCVCDQNF-----QERNNTCIA 3882
+Q ++C D++EC+ +H C N +GSY C C F +E + C+A
Sbjct: 865 WQ----GQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLA 917
Score = 79.3 bits (194), Expect = 8e-14
Identities = 134/603 (22%), Positives = 205/603 (33%), Gaps = 127/603 (21%)
Query: 2459 DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGD------RILLED---NRCVTKNSS 2509
D N C +PC NGG D + NG C+C+ ++ +++ N C+ + +
Sbjct: 757 DKNECLSNPCQ--NGGTCDNLV---NG-YRCTCKKGFKGYNCQVNIDECASNPCLNQGTC 810
Query: 2510 CNAYSEFECG-----NGECIDYQLT------CDGIPHCKDKSDEKLLYC------ENRSC 2552
+ S + C G+ L C+ CK+ + + C + + C
Sbjct: 811 FDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRC 870
Query: 2553 RRGFKPCYNRRCIPHGKLCDGEN-----DCGDNSDELDCKVSTCATVEFRCADGTCIPRS 2607
C ++ C+ HG LC +C +DC+ + C +G
Sbjct: 871 TIDIDECISKPCMNHG-LCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGG----- 924
Query: 2608 ARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGD 2667
C D + +C C + T C S C C D
Sbjct: 925 -------SCMDGVNTFSCL---CLPGFTGDKCQTDMNECLSEP--------CKNGGTCSD 966
Query: 2668 YSDELKCPVQ---NKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC-------D 2717
Y + C Q + CE N C C C DG + F C
Sbjct: 967 YVNSYTCKCQAGFDGVHCENNINECTESSCF-------NGGTCVDGINSFSCLCPVGFTG 1019
Query: 2718 SSCSWNQFACSAQKCISKHWICDGEDD--CGDGLDESDSICGAITCAADMFSCQGSRACV 2775
S C CS+ C+++ DG C L + C + C+ CV
Sbjct: 1020 SFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCV 1079
Query: 2776 PRHWLCDGERDCPDGSDELSTAGC-APNNTCDENAFMCHNKVCIPKQFVCDHDDDC-GDG 2833
+ + + CP G + A C PN +CD A ++ + + +C H C G
Sbjct: 1080 QKK--AESQCLCPSG---WAGAYCDVPNVSCDIAA----SRRGVLVEHLCQHSGVCINAG 1130
Query: 2834 SDESPQC--GYR--QCGTEEFSCADGRCLLN-TQWQCDGDFDCPDHSDEAPLNPKCKSAE 2888
+ QC GY C + CA C T G + C +C
Sbjct: 1131 NTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRC-----------ECVPGY 1179
Query: 2889 QSCNSSFFM--CKNGRCIPSGGLCDN-----KDDCGDGSDERNC--HINECLSKKVSGCS 2939
Q N + + C+N C +GG C + K C G+ C +I++C
Sbjct: 1180 QGVNCEYEVDECQNQPC-QNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNG 1238
Query: 2940 QDCQDLPVSYKCKCWPGFQLKDDGKTCV-DIDECSSGFPCSQQ----CINTYGTYKCLCT 2994
C D Y C+C PGF G+ C DI+EC S PCS + CI Y C+C
Sbjct: 1239 GQCMDRIGGYSCRCLPGFA----GERCEGDINECLSN-PCSSEGSLDCIQLTNDYLCVCR 1293
Query: 2995 DGY 2997
+
Sbjct: 1294 SAF 1296
Score = 74.3 bits (181), Expect = 3e-12
Identities = 158/665 (23%), Positives = 228/665 (34%), Gaps = 191/665 (28%)
Query: 2459 DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC----RGDRILLEDNRCVTKNSSCNAYS 2514
D N C PC +D L G C C +G LE N C +++ C
Sbjct: 456 DINECHSDPCQ------NDATCLDKIGGFTCLCMPGFKGVHCELEINEC--QSNPC---- 503
Query: 2515 EFECGNGECID----YQLTCD-GI--PHCKDKSDEKLLYCENRSCRRGFKPCYNRRCI-- 2565
NG+C+D +Q C G P C+ D+ C + C G K CI
Sbjct: 504 ---VNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD----CSSTPCLNGAK------CIDH 550
Query: 2566 PHGKLCDGEND-----CGDNSDELDCKVSTCATVEFRCADG----TCIPRSARCN---QN 2613
P+G C C +N D +C C +C DG TCI CN
Sbjct: 551 PNGYECQCATGFTGVLCEENID--NCDPDPCH--HGQCQDGIDSYTCI-----CNPGYMG 601
Query: 2614 IDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCN-----STSLCVLPTWICDGS----ND 2664
C+D DE C ++ C + + G+ +CN S C + C +
Sbjct: 602 AICSDQIDE--CYSSPCLNDGRCIDLVNGY-QCNCQPGTSGVNCEINFDDCASNPCIHGI 658
Query: 2665 CGDYSDELKC---PVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCS 2721
C D + C P +C + C S C C +G + F C
Sbjct: 659 CMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGA-------TCINGVNGFRCICPEG 711
Query: 2722 WNQFACSAQ--KCISKHWICDGEDDCGDGLDESDSICGA----ITCAADMFSC-----QG 2770
+ +C +Q +C+S I +C GL +C A I C D C Q
Sbjct: 712 PHHPSCYSQVNECLSNPCI---HGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQN 768
Query: 2771 SRAC--VPRHWLCDGER-----DCPDGSDELSTAGCAPNNTC--DENAFMCHNKV----- 2816
C + + C ++ +C DE ++ C TC D + + CH +
Sbjct: 769 GGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGK 828
Query: 2817 --------CIPKQFVCDHDDDCGDGSD-ESPQC----GYR--QCGTEEFSCADGRCLL-- 2859
C P C++ C + + ES C G++ +C + C C+
Sbjct: 829 NCQTVLAPCSPNP--CENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHG 886
Query: 2860 ---NTQ--WQCD-----GDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGL 2909
NTQ + C+ DC + D+ NP + F C C+P
Sbjct: 887 LCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCL---CLP---- 939
Query: 2910 CDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKD-------- 2961
G D+ +NECLS+ C D SY CKC GF
Sbjct: 940 -------GFTGDKCQTDMNECLSEPCKN-GGTCSDYVNSYTCKCQAGFDGVHCENNINEC 991
Query: 2962 ------DGKTCVD---------------------IDECSSGFPCSQQ--CINTYGTYKCL 2992
+G TCVD I+ECSS PC + C++ GTY+C
Sbjct: 992 TESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSS-HPCLNEGTCVDGLGTYRCS 1050
Query: 2993 CTDGY 2997
C GY
Sbjct: 1051 CPLGY 1055
Score = 69.7 bits (169), Expect = 6e-11
Identities = 144/615 (23%), Positives = 205/615 (33%), Gaps = 150/615 (24%)
Query: 2460 TNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECG 2519
T++C PCA NG C N + +C C +C T + C+ + G
Sbjct: 145 TDACLSHPCA--NGST---CTTVAN-QFSCKCLTG---FTGQKCETDVNECDIPGHCQHG 195
Query: 2520 NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGD 2579
G C L G C+ YC++ + PC C+ +G C GD
Sbjct: 196 -GTC----LNLPGSYQCQCPQGFTGQYCDSL-----YVPCAPSPCV-NGGTC---RQTGD 241
Query: 2580 NSDELDC----KVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYK 2635
+ E +C + STC C + RC C D + NC +
Sbjct: 242 FTFECNCLPGFEGSTCERNIDDCPNH-------RCQNGGVCVDGVNTYNC---------R 285
Query: 2636 LGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHK---CEENYFSCPSG 2692
+ TG C+L C C + + C N C EN C
Sbjct: 286 CPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFA 345
Query: 2693 RCILNTWICDGQKD----CEDGRDEF--HCDSSCSWN---QFACSAQKCISKHWICDGED 2743
C + D C +G+ H D +C N + A ++ +IC
Sbjct: 346 SCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICT--- 402
Query: 2744 DCGDGLDESDSICGAITCA-ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPN 2802
C G +D CA A+ C+ + CV DG C E P
Sbjct: 403 -CPQGYKGADCTEDVDECAMANSNPCEHAGKCVNT----DGAFHC-----ECLKGYAGPR 452
Query: 2803 NTCDENAFMCHNKVCIPKQFVCDHDDDCGD---GSDESPQCGYR--QCGTEEFSCADGRC 2857
C+ + CH+ C +D C D G G++ C E C C
Sbjct: 453 --CEMDINECHSDPC-------QNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPC 503
Query: 2858 LLNTQ-------WQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNG-RCIP---- 2905
+ N Q +QC CP P C+ C+S+ C NG +CI
Sbjct: 504 VNNGQCVDKVNRFQCL----CPPGFT----GPVCQIDIDDCSST--PCLNGAKCIDHPNG 553
Query: 2906 ---------SGGLCDNKDD-----------CGDGSDERNC-------------HINECLS 2932
+G LC+ D C DG D C I+EC S
Sbjct: 554 YECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYS 613
Query: 2933 KKVSGCSQD--CQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGFPCSQQ-CINTYGT 2988
S C D C DL Y+C C PG G C ++ D+C+S PC C++
Sbjct: 614 ---SPCLNDGRCIDLVNGYQCNCQPG----TSGVNCEINFDDCASN-PCIHGICMDGINR 665
Query: 2989 YKCLCTDGYEIQPDN 3003
Y C+C+ G+ Q N
Sbjct: 666 YSCVCSPGFTGQRCN 680
Score = 68.2 bits (165), Expect = 2e-10
Identities = 167/749 (22%), Positives = 251/749 (33%), Gaps = 191/749 (25%)
Query: 3271 DVSKHLCMINNGGCSHLCLLAPGKTHTCACP---TNFYLAADNRTCLSNCTASQF--RCK 3325
D H C NGG +C+ T+ C CP T + D CL A Q C
Sbjct: 263 DCPNHRCQ--NGG---VCVDGVN-TYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCA 316
Query: 3326 TDK------CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRF---QCGTGLCALP---- 3372
C+ W + DDC S+ DDC C PG + + C P
Sbjct: 317 NRNGGYGCVCVNGW----SGDDC---SENIDDCAFASCTPGSTCIDRVASFSCMCPEGKA 369
Query: 3373 AFICDGENDCGDNSDELN--CDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERD 3430
+C ++ C N CDT+ L+GQ+ CT Q G D D ++
Sbjct: 370 GLLCHLDDACISNPCHKGALCDTNP-LNGQYICTCPQGY-------KGADCTEDVDECAM 421
Query: 3431 CPENSC--------SPDYFQCKTTK-----HCISKLWVCDEDPDCADASDEANCDKKTCG 3477
N C + F C+ K C + C DP ++A C K G
Sbjct: 422 ANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDP----CQNDATCLDKIGG 477
Query: 3478 PHEFQC------KNNNCIPDHWRCDSQNDCSDNS---DEEN-----CKP----QTCTLKD 3519
F C K +C + C S N C +N D+ N C P C +
Sbjct: 478 ---FTCLCMPGFKGVHCELEINECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDI 533
Query: 3520 FLCANGDCVSSRFWCDG----DFDCADGSDERNCETSCSK-DQFRCSNGQCIPAKWKCDG 3574
C++ C++ D + CA G CE + D C +GQC DG
Sbjct: 534 DDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQ------DG 587
Query: 3575 HED----CKYGEDEKSCEPASPTCSSREYICASDG-CI-------------SASLKCNGE 3616
+ C G C C S C +DG CI ++ + C
Sbjct: 588 IDSYTCICNPGYMGAICSDQIDECYSSP--CLNDGRCIDLVNGYQCNCQPGTSGVNCEIN 645
Query: 3617 YD-----------CADGSDEMDCVT--------------ECKEDQFRCKNKAHCIPIRWL 3651
+D C DG + CV EC + C+ A CI
Sbjct: 646 FDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNP--CRKGATCI----- 698
Query: 3652 CDGIHD----CVDGSDEENCERGGNICRADEFLCNNSLCKLHFW--VCDG---------- 3695
+G++ C +G +C N C ++ + N L + +CD
Sbjct: 699 -NGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVD 757
Query: 3696 EDDCGDNSDEAPDMCVKFL----CPSTRPHRCRNNRICLQ--SEQMCNGIDECGDNSDED 3749
+++C N + C + C + + N ++ + + C C D+
Sbjct: 758 KNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGY 817
Query: 3750 HCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDD-------CGDGSDEQGCRIAPTE 3802
C L Y + C+ CS C + C + C G Q C I E
Sbjct: 818 TCHCVLPYTGKNCQTVLAPCSPNPCENAAV-CKESPNFESYTCLCAPGWQGQRCTIDIDE 876
Query: 3803 YTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQC-EDLNECLVFGTCSH--QCI 3859
+ PC + C+ + S C C PGF C ED+++CL C + C+
Sbjct: 877 CISK----PCMNHGLCHNTQGSYMCECPPGF----SGMDCEEDIDDCLA-NPCQNGGSCM 927
Query: 3860 NVEGSYKCVCDQNF-----QERNNTCIAE 3883
+ ++ C+C F Q N C++E
Sbjct: 928 DGVNTFSCLCLPGFTGDKCQTDMNECLSE 956
Score = 65.5 bits (158), Expect = 1e-09
Identities = 72/309 (23%), Positives = 105/309 (33%), Gaps = 86/309 (27%)
Query: 4176 CLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLT-CENGGRCILNEKGD 4234
C+DL F C P +C E +DD + C NGG+C ++ G
Sbjct: 1202 CIDLVNHFKCSCPPGTRGLLCEEN-------------IDDCARGPHCLNGGQC-MDRIGG 1247
Query: 4235 LRCHCWPSYSGERCEVN-----------------------------------HCSNY--- 4256
C C P ++GERCE + HC +
Sbjct: 1248 YSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDV 1307
Query: 4257 -----CQNGGTCV--PSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYC 4309
C NGGTC ++ C C GF+G C + + C+ G C+ TA P C
Sbjct: 1308 CPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASG-PRC 1366
Query: 4310 HC-QPEYTGDRCQYYVCHHYCVNSESC-TIGDDGSVECVCPTRYEGPKCEVDKC------ 4361
C P C C H SC C C + G +CE+
Sbjct: 1367 FCPSPRDCESGCASSPCQH----GGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPP 1422
Query: 4362 VRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQL---DPETNVPVCLCS 4418
C +C +K + + C + +CQ ++GG C L +P N L
Sbjct: 1423 ATCLSQYC-ADKARDGV---CDEACNSHACQ------WDGGDCSLTMENPWANCSSPLPC 1472
Query: 4419 TNWSGTQCE 4427
++ QC+
Sbjct: 1473 WDYINNQCD 1481
Score = 65.1 bits (157), Expect = 2e-09
Identities = 127/598 (21%), Positives = 197/598 (32%), Gaps = 141/598 (23%)
Query: 2447 PHQPMGIIAVANDTNSCELSPCALLN--GGCHDLCLLTPNGRVNCSCRGDRILLEDNRCV 2504
PH P + + N C +PC N GG L G V +C D+ N C
Sbjct: 712 PHHP----SCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQ 767
Query: 2505 TKNSSCNAYSEF------------------ECGNGECIDYQLTCDGIP----HCKDKSDE 2542
+ N + + EC + C++ D I HC
Sbjct: 768 NGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHC------ 821
Query: 2543 KLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGT 2602
+L ++C+ PC C + +C + + + TC CA G
Sbjct: 822 -VLPYTGKNCQTVLAPCSPNPC-ENAAVC---------KESPNFESYTCL-----CAPGW 865
Query: 2603 CIPRSARCNQNIDCADASDEKN---CNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWIC 2659
+ RC +ID + N C+NT ++ + +G C+ C
Sbjct: 866 ---QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANP--C 920
Query: 2660 DGSNDCGDYSDELKC---PVQNKHKCEENYFSCPSGRC--------ILNTWICDGQKDCE 2708
C D + C P KC+ + C S C +N++ C C+
Sbjct: 921 QNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCK----CQ 976
Query: 2709 DGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGA----ITCAAD 2764
G D HC+++ + C+ C + C DG++ +C C +
Sbjct: 977 AGFDGVHCENNIN----ECTESSCFNG-------GTCVDGINSFSCLCPVGFTGSFCLHE 1025
Query: 2765 MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCA-PNNTCDENAFMCHNKVCIPKQFV 2823
+ C C E C DG L T C+ P +N C V + +
Sbjct: 1026 INECSSHP--------CLNEGTCVDG---LGTYRCSCPLGYTGKN---CQTLVNLCSRSP 1071
Query: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883
C + C ES +CL + W D P+ S + + +
Sbjct: 1072 CKNKGTCVQKKAES------------------QCLCPSGW-AGAYCDVPNVSCDIAASRR 1112
Query: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCH--INECLSKKVSGCSQD 2941
E C S G CI +G + C G C ++EC S
Sbjct: 1113 GVLVEHLCQHS------GVCINAGNT--HYCQCPLGYTGSYCEEQLDECASNPCQH-GAT 1163
Query: 2942 CQDLPVSYKCKCWPGFQLKDDGKTC-VDIDECSSGFPCSQ--QCINTYGTYKCLCTDG 2996
C D Y+C+C PG+Q G C ++DEC + PC CI+ +KC C G
Sbjct: 1164 CSDFIGGYRCECVPGYQ----GVNCEYEVDECQNQ-PCQNGGTCIDLVNHFKCSCPPG 1216
Score = 63.9 bits (154), Expect = 3e-09
Identities = 164/752 (21%), Positives = 250/752 (33%), Gaps = 176/752 (23%)
Query: 3246 ADRLSLIYSWHAITD---IQVYHSYR---QPDVSKHLCMIN-----NGGCSHLCLLAPGK 3294
+D++ YS + D I + + Y+ QP S C IN + C H +
Sbjct: 605 SDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGIN 664
Query: 3295 THTCACPTNFY---LAADNRTCLSNCTASQFRCKTD----KCIPFWWKCDTVDDCGDGSD 3347
++C C F D C SN C +CI C +G
Sbjct: 665 RYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCI-----------CPEGPH 713
Query: 3348 EP------DDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQ- 3400
P ++C C G C GL G D+ C ++ C +G
Sbjct: 714 HPSCYSQVNECLSNPCIHGN--CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGT 771
Query: 3401 -------FKCT-----KNQKCIPVNLR------CNGQDDCGDEEDERDCPENSCSPDYFQ 3442
++CT K C VN+ C Q C D+ C C Y
Sbjct: 772 CDNLVNGYRCTCKKGFKGYNC-QVNIDECASNPCLNQGTCFDDISGYTC---HCVLPY-- 825
Query: 3443 CKTTKHCISKLWVCDEDP--DCADASDEANCDKKTC----GPHEFQCKNN--NCIPDHWR 3494
T K+C + L C +P + A + N + TC G +C + CI
Sbjct: 826 --TGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKP-- 881
Query: 3495 CDSQNDCSDNSDEENCK-PQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC---- 3549
C + C + C+ P + D DC+++ C C DG + +C
Sbjct: 882 CMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANP--CQNGGSCMDGVNTFSCLCLP 939
Query: 3550 ---ETSCSKDQFRCSNGQCIPAKWKCDGHED-----CKYGEDEKSCEPASPTCSSREYIC 3601
C D C + C C + + C+ G D CE C+ E C
Sbjct: 940 GFTGDKCQTDMNECLSEPCKNGG-TCSDYVNSYTCKCQAGFDGVHCENNINECT--ESSC 996
Query: 3602 ASDG-CISA--SLKCNGEYDCADGSDEMDCVTECKE-DQFRCKNKAHCIPIRWLCDGIHD 3657
+ G C+ S C C G C+ E E C N+ C+ DG+
Sbjct: 997 FNGGTCVDGINSFSCL----CPVGFTGSFCLHEINECSSHPCLNEGTCV------DGL-- 1044
Query: 3658 CVDGSDEENCERG--GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLC 3715
G+ +C G G C+ LC+ S CK + C E+ +C
Sbjct: 1045 ---GTYRCSCPLGYTGKNCQTLVNLCSRSPCK-------NKGTCVQKKAESQCLCPSGWA 1094
Query: 3716 ------PSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFAC 3769
P+ + R L E +C C + + +C L Y C++ C
Sbjct: 1095 GAYCDVPNVSCDIAASRRGVLV-EHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDEC 1153
Query: 3770 SNK-----------------KCIP--MDLQCD-RLDDCGDGSDEQG-------------C 3796
++ +C+P + C+ +D+C + + G C
Sbjct: 1154 ASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSC 1213
Query: 3797 RIAPTEYTCEDNVNPCGDDAYC---NQIKTSV---FCRCKPGFQRNMKNRQCE-DLNECL 3849
CE+N++ C +C Q + CRC PGF +CE D+NECL
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFA----GERCEGDINECL 1269
Query: 3850 VFGTCSHQ----CINVEGSYKCVCDQNFQERN 3877
CS + CI + Y CVC F R+
Sbjct: 1270 S-NPCSSEGSLDCIQLTNDYLCVCRSAFTGRH 1300
Score = 63.9 bits (154), Expect = 3e-09
Identities = 164/685 (23%), Positives = 237/685 (34%), Gaps = 157/685 (22%)
Query: 3271 DVSKHLCMIN---NGG-CSHLCLLAPGKTHTCACPTNF--YLAADN-RTCLSNCTASQFR 3323
+V K+ C+ N NGG C +L + C C F Y N C SN +Q
Sbjct: 755 EVDKNECLSNPCQNGGTCDNLV-----NGYRCTCKKGFKGYNCQVNIDECASNPCLNQGT 809
Query: 3324 CKTD------KCI-PFWWK-CDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
C D C+ P+ K C TV S P + + F+ T LCA P +
Sbjct: 810 CFDDISGYTCHCVLPYTGKNCQTV--LAPCSPNPCENAAVCKESPNFESYTCLCA-PGW- 865
Query: 3376 CDGENDCGDNSDELNCDTHVCLS--------GQFKCTKNQKCIPVNLRCNGQDDCGDEED 3427
G+ C + DE C + C++ G + C +C P G EED
Sbjct: 866 -QGQR-CTIDIDE--CISKPCMNHGLCHNTQGSYMC----ECPP------GFSGMDCEED 911
Query: 3428 ERDCPENSCSP--------DYFQCK-----TTKHCISKLWVCDEDP-----DCADASDEA 3469
DC N C + F C T C + + C +P C+D +
Sbjct: 912 IDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSY 971
Query: 3470 NCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC------KPQTCTLKDFLCA 3523
C K G C+NN C + C D + +C C + C+
Sbjct: 972 TC-KCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECS 1030
Query: 3524 NGDCVSSRFWCDG----DFDCADGSDERNCETS---CSKDQFRCSN-GQCIPAKWKCDGH 3575
+ C++ DG C G +NC+T CS+ C N G C+ K +
Sbjct: 1031 SHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSP--CKNKGTCVQKK--AESQ 1086
Query: 3576 EDCKYGEDEKSCEPASPTC---SSR-----EYICASDG-CISAS----LKCNGEYDCADG 3622
C G C+ + +C +SR E++C G CI+A +C Y +
Sbjct: 1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYC 1146
Query: 3623 SDEMDCVTECKEDQFRCKNKAHCIPI--RWLCDGIHDCVDGSDEENCERGGNICRADEFL 3680
+++D EC + C++ A C + C+ CV G NCE DE
Sbjct: 1147 EEQLD---ECASNP--CQHGATCSDFIGGYRCE----CVPGYQGVNCEY-----EVDE-- 1190
Query: 3681 CNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLC---PSTRPHRCRNN-RICLQSEQMC 3736
C N C+ N D+ F C P TR C N C +
Sbjct: 1191 CQNQPCQ--------------NGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCL 1236
Query: 3737 NGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPM-DLQCDRLDD---CGDGSD 3792
NG +C D C + C+ D C + C L C +L + C
Sbjct: 1237 NG-GQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCV---- 1291
Query: 3793 EQGCRIAPTEYTCEDNVNPC--------GDDAYCNQIKTSVFCRCKPGFQRNMKNRQCED 3844
CR A T CE V+ C G A + + CRC PGF C
Sbjct: 1292 ---CRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQ 1348
Query: 3845 LNECLVFGTCSHQCINVEGSYKCVC 3869
+ +C QC++ +C C
Sbjct: 1349 V-KC----RKGEQCVHTASGPRCFC 1368
Score = 60.1 bits (144), Expect = 5e-08
Identities = 124/519 (23%), Positives = 170/519 (32%), Gaps = 124/519 (23%)
Query: 795 DNMCRVNNGGCSTL--CLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHIC------- 845
D N+ C C+ G C C L G C + E C
Sbjct: 417 DECAMANSNPCEHAGKCVNTDGAFHCEC----LKGYAGPRCEMDINECHSDPCQNDATCL 472
Query: 846 -KAGEFRC------KNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPD---------D 889
K G F C K HC +C + +G D VN F CP D
Sbjct: 473 DKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQID 532
Query: 890 QFKCQNNRCIPKRWLCDGAN--DCGSNEDESNQTCTARTCQVDQFSCGNGRCIP--RAWL 945
C + C+ D N +C + C D C +G+C ++
Sbjct: 533 IDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYT 592
Query: 946 CDREDD-----CGDQTDEMASCEFPTCEPLTQFVCKSGRCIS--SKWHCDSDDDCGDGSD 998
C C DQ DE C C GRCI + + C +C G+
Sbjct: 593 CICNPGYMGAICSDQIDE---CYSSPC-------LNDGRCIDLVNGYQC----NCQPGTS 638
Query: 999 EVGCVHSCFDNQFRCSSGRCIPGHWAC-DGDND----CGDFSDEAQINCTKEEIHSPAGC 1053
V C + FD+ C+S CI H C DG N C + N +E C
Sbjct: 639 GVNCEIN-FDD---CASNPCI--HGICMDGINRYSCVCSPGFTGQRCNIDIDE------C 686
Query: 1054 NGNEFQCHPDGNCVPDL--WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCIN 1111
N C C+ + +RC C +G C + C TG
Sbjct: 687 ASN--PCRKGATCINGVNGFRC----ICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG 740
Query: 1112 KAWVCDG---DIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSD 1168
+CD I+CE D+++C S +PC N + + L NG +
Sbjct: 741 YKCLCDAGWVGINCE--VDKNECLS-------NPCQNGGTC----DNLVNGYRCTCKKGF 787
Query: 1169 EGYLC----DECS----LNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV----- 1215
+GY C DEC+ LN G C + S G C C L K C+ V
Sbjct: 788 KGYNCQVNIDECASNPCLNQGTCFDDIS-----GYTCHC----VLPYTGKNCQTVLAPCS 838
Query: 1216 -DYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCT 1253
+ C N C + +T C C GW+ G+ CT
Sbjct: 839 PNPCENAAVCKESPNFESYT--CLCAPGWQ----GQRCT 871
Score = 59.3 bits (142), Expect = 9e-08
Identities = 55/250 (22%), Positives = 83/250 (33%), Gaps = 70/250 (28%)
Query: 3639 CKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDD 3698
C AH + R DG CV+ G C+ E C D
Sbjct: 19 CAAPAHALQCR---DGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE--------YCQHRDP 67
Query: 3699 CGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYK 3758
C N RC+N C+ + C + C ++
Sbjct: 68 CEKN-------------------RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 108
Query: 3759 ---ARPC---------KKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCE 3806
+RPC +D + C+ C G + C ++T
Sbjct: 109 CFVSRPCLNGGTCHMLSRDTYECT----------------CQVGFTGKEC-----QWTDA 147
Query: 3807 DNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCE-DLNECLVFGTCSH--QCINVEG 3863
+PC + + C + C+C GF ++CE D+NEC + G C H C+N+ G
Sbjct: 148 CLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCETDVNECDIPGHCQHGGTCLNLPG 203
Query: 3864 SYKCVCDQNF 3873
SY+C C Q F
Sbjct: 204 SYQCQCPQGF 213
Score = 58.5 bits (140), Expect = 1e-07
Identities = 90/426 (21%), Positives = 140/426 (32%), Gaps = 91/426 (21%)
Query: 3501 CSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQF-- 3558
C + E C+ + K+ G CV+ CA G +C+ S S F
Sbjct: 53 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVS 112
Query: 3559 -RCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEY 3617
C NG + C+ G K C+ +D C+S C
Sbjct: 113 RPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-------------WTDACLSH--PCANGS 157
Query: 3618 DCADGSDEMDCV-------TECKEDQFRCKNKAHC--------IPIRWLCDGIHDCVDGS 3662
C +++ C +C+ D C HC +P + C C G
Sbjct: 158 TCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQC----QCPQGF 213
Query: 3663 DEENCER-----------GGNICRAD---EFLCN------NSLCKLHFWVCDGEDDCGDN 3702
+ C+ G CR F CN S C+ + DDC ++
Sbjct: 214 TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNI------DDCPNH 267
Query: 3703 SDEAPDMCVKFL------CPS--TRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGK 3754
+ +CV + CP T + CL C C + + C
Sbjct: 268 RCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCV 327
Query: 3755 LTYKARPCKKDEFACSNKKCIPMDLQCDRLDD----CGDGSDEQGCRIAPTEYTCEDNVN 3810
+ C ++ C+ C P DR+ C +G C + + C N
Sbjct: 328 NGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHL---DDACIS--N 382
Query: 3811 PCGDDAYC--NQIKTSVFCRCKPGFQRNMKNRQC-EDLNECLVFGT--CSH--QCINVEG 3863
PC A C N + C C G+ K C ED++EC + + C H +C+N +G
Sbjct: 383 PCHKGALCDTNPLNGQYICTCPQGY----KGADCTEDVDECAMANSNPCEHAGKCVNTDG 438
Query: 3864 SYKCVC 3869
++ C C
Sbjct: 439 AFHCEC 444
Score = 54.7 bits (130), Expect = 2e-06
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 46/201 (22%)
Query: 39 CHDHVTC--VSQSWLCDGDP-----DCPDDSDESL-DTCPEEVEIKCPLNHIACL----- 85
C +H C S++C+ P DC +D D+ L + C +N +CL
Sbjct: 882 CMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGF 941
Query: 86 -------GTNKCVHLSQLCNGVLDCPD-----------GYDEGVHCQELLSNCQQLNCQY 127
N+C LS+ C C D G+D GVHC+ ++ C + +C
Sbjct: 942 TGDKCQTDMNEC--LSEPCKNGGTCSDYVNSYTCKCQAGFD-GVHCENNINECTESSCFN 998
Query: 128 KCTMVR--NSTRCYCEDGFEITEDGRSCKDQ-DECAVYGTCSQ-TCRNTHGSYTCSCVEG 183
T V NS C C GF G C + +EC+ + ++ TC + G+Y CSC G
Sbjct: 999 GGTCVDGINSFSCLCPVGF----TGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLG 1054
Query: 184 YLMQPDNRSCKAKIEPTDRPP 204
Y ++C+ + R P
Sbjct: 1055 Y----TGKNCQTLVNLCSRSP 1071
Score = 53.1 bits (126), Expect = 6e-06
Identities = 47/154 (30%), Positives = 62/154 (40%), Gaps = 15/154 (9%)
Query: 39 CHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCN 98
C + TCV+Q+ L G C S + + C C ++ CL C H+
Sbjct: 73 CQNGGTCVAQAML--GKATCRCASGFTGEDCQYSTSHPCFVSR-PCLNGGTC-HMLSRDT 128
Query: 99 GVLDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-D 155
C G+ G CQ C C CT V N C C GF G+ C+ D
Sbjct: 129 YECTCQVGFT-GKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCETD 182
Query: 156 QDECAVYGTCSQ--TCRNTHGSYTCSCVEGYLMQ 187
+EC + G C TC N GSY C C +G+ Q
Sbjct: 183 VNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQ 216
Score = 52.4 bits (124), Expect = 1e-05
Identities = 97/385 (25%), Positives = 131/385 (34%), Gaps = 96/385 (24%)
Query: 2503 CVTKNSSCNA-YSEFECGNGECIDYQLTCDGIPH--CKDKSDEKLLYCENR--SCRRGFK 2557
CV N Y EC N C + D + H C + L CE C RG
Sbjct: 1175 CVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARG-P 1233
Query: 2558 PC------------YNRRCIPH--GKLCDGE-NDCGDN----SDELDCKVSTCATVEFRC 2598
C Y+ RC+P G+ C+G+ N+C N LDC T
Sbjct: 1234 HCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLT-------- 1285
Query: 2599 ADGTCIPRSA----RCNQNID------------CADASDEKNCNNTDCTHFYKLGVK--- 2639
D C+ RSA C +D CA AS+ + C + G +
Sbjct: 1286 NDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFS-GARCQS 1344
Query: 2640 TTGFIRCNSTSLCVL----PTWICDGSNDCGDYSDELKCPVQNKHKCEEN----YFSCP- 2690
+ G ++C CV P C DC S P Q+ C Y+SC
Sbjct: 1345 SCGQVKCRKGEQCVHTASGPRCFCPSPRDCE--SGCASSPCQHGGSCHPQRQPPYYSCQC 1402
Query: 2691 -----SGRCILNTW-------ICDGQKDCEDGRDEFHCDSSCS-----WNQFACSAQKCI 2733
RC L T C Q + RD CD +C+ W+ CS +
Sbjct: 1403 APPFSGSRCELYTAPPSTPPATCLSQYCADKARDGV-CDEACNSHACQWDGGDCSLT--M 1459
Query: 2734 SKHWI-CDGEDDCGDGLD-ESDSICGAITCAADMFSCQG-SRACVPRHWLCDGERD--CP 2788
W C C D ++ + D +C + C D F CQG S+ C + D +D C
Sbjct: 1460 ENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCD 1519
Query: 2789 DGS-------DELSTAGCAPNNTCD 2806
G D L A P N +
Sbjct: 1520 QGCNSEECGWDGLDCAADQPENLAE 1544
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/241 (23%), Positives = 85/241 (35%), Gaps = 53/241 (21%)
Query: 3350 DDCPEFRCQPGRFQCGTGLCALPAFICDGEN-DCGDNSDELNCDTHVCLSGQFKCTKNQK 3408
D CP+ C G G CA+ + + DG C C + GQ KC K ++
Sbjct: 1306 DVCPQMPCLNG------GTCAVASNMPDGFICRCPPGFSGARCQSSC---GQVKCRKGEQ 1356
Query: 3409 CIPV----NLRCNGQDDCGDEEDERDCPENSCS----------PDYFQCKTTKHCI-SKL 3453
C+ C DC E C + C P Y+ C+ S+
Sbjct: 1357 CVHTASGPRCFCPSPRDC-----ESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRC 1411
Query: 3454 WVCDEDPD----------CADASDEANCDKKTCGPHEFQCKNNNC---IPDHW-RCDSQN 3499
+ P CAD + + CD+ C H Q +C + + W C S
Sbjct: 1412 ELYTAPPSTPPATCLSQYCADKARDGVCDE-ACNSHACQWDGGDCSLTMENPWANCSSPL 1470
Query: 3500 DCSD---NSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKD 3556
C D N +E C C +F +C + C D CAD + +C+ C+ +
Sbjct: 1471 PCWDYINNQCDELCNTVECLFDNF-----ECQGNSKTCKYDKYCADHFKDNHCDQGCNSE 1525
Query: 3557 Q 3557
+
Sbjct: 1526 E 1526
Score = 50.4 bits (119), Expect = 4e-05
Identities = 116/479 (24%), Positives = 152/479 (31%), Gaps = 131/479 (27%)
Query: 798 CRVNNGGCSTLCLAIPGGRVCACADNQLLD---ENGTTCTFNPGEALPHICKAGEFRCKN 854
C G LC A G C N+ L +NG TC N CK G K
Sbjct: 734 CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCD-NLVNGYRCTCKKG---FKG 789
Query: 855 RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSC--PDDQFKCQN--NRCIPKRWLCDGAND 910
+C +C + G+ D ++ + C P CQ C P C+ A
Sbjct: 790 YNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNP--CENAAV 847
Query: 911 CGSNEDESNQTCTA------RTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEF 964
C + + + TC + C +D C + C+ LC T CE
Sbjct: 848 CKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHG-LCHN-------TQGSYMCE- 898
Query: 965 PTCEPLTQFVCKSGRCISSKWHCDSD-DDCGDGSDEVGCVHSCFD--NQFRCSSGRCIPG 1021
C G S C+ D DDC + G SC D N F C C+PG
Sbjct: 899 ----------CPPG---FSGMDCEEDIDDCLANPCQNG--GSCMDGVNTFSCL---CLPG 940
Query: 1022 HWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNG--NEFQCHPDGNCVPDLWRCDGEKDC 1079
GD C E + C+ N + C C
Sbjct: 941 F--------TGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCK-----------------C 975
Query: 1080 EDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPP 1139
+ G D C I C T+ SC++ G C+ D +SF C
Sbjct: 976 QAGFDGVHCENNINEC---TESSCFNGGTCV------------------DGINSFSC--- 1011
Query: 1140 KHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIV-CS 1198
P S CL +ECS + C N + V G G CS
Sbjct: 1012 LCPVGFTGSFCLHE-------------------INECSSHP--CLNEGTCVDGLGTYRCS 1050
Query: 1199 CPEGLQLNKDNKTCE-IVDYCSNH-LKCSQVCEQHKHTVKCSCYEGWK---LDVDGESC 1252
CP G K C+ +V+ CS K C Q K +C C GW DV SC
Sbjct: 1051 CPLGYT----GKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSC 1105
Score = 45.8 bits (107), Expect = 0.001
Identities = 45/149 (30%), Positives = 63/149 (42%), Gaps = 25/149 (16%)
Query: 52 CDGDPDCPDDSDESLDTCPE-EVEIKCPLNHIACLGTNKCVHLSQLC-----NG--VLDC 103
C C D CPE + + C L+ AC+ +N C H LC NG + C
Sbjct: 347 CTPGSTCIDRVASFSCMCPEGKAGLLCHLDD-ACI-SNPC-HKGALCDTNPLNGQYICTC 403
Query: 104 PDGYDEGVHCQELLSNCQQLN---CQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQD 157
P GY +G C E + C N C++ KC + C C G+ G C+ D +
Sbjct: 404 PQGY-KGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA----GPRCEMDIN 458
Query: 158 ECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
EC C TC + G +TC C+ G+
Sbjct: 459 ECHS-DPCQNDATCLDKIGGFTCLCMPGF 486
Score = 44.7 bits (104), Expect = 0.002
Identities = 40/132 (30%), Positives = 55/132 (41%), Gaps = 27/132 (20%)
Query: 58 CPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELL 117
C D DE + K +NH C T S +C +CP G+ G+ C+E +
Sbjct: 870 CTIDIDECIS--------KPCMNHGLCHNTQG----SYMC----ECPPGFS-GMDCEEDI 912
Query: 118 SNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-DQDECAVYGTCSQ--TCRNT 172
+C CQ C N+ C C GF G C+ D +EC + C TC +
Sbjct: 913 DDCLANPCQNGGSCMDGVNTFSCLCLPGFT----GDKCQTDMNEC-LSEPCKNGGTCSDY 967
Query: 173 HGSYTCSCVEGY 184
SYTC C G+
Sbjct: 968 VNSYTCKCQAGF 979
Score = 43.5 bits (101), Expect = 0.005
Identities = 34/127 (26%), Positives = 53/127 (41%), Gaps = 24/127 (18%)
Query: 76 KCPLNHIACL--------GTNKCVHLSQLCNGVL-----DCPDGYDEGVHCQELLSNCQQ 122
+CPL + +N C H C+ + +C GY +GV+C+ + CQ
Sbjct: 1136 QCPLGYTGSYCEEQLDECASNPCQH-GATCSDFIGGYRCECVPGY-QGVNCEYEVDECQN 1193
Query: 123 LNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCKDQ-DECAVYGTCSQ--TCRNTHGSYT 177
CQ C + N +C C G G C++ D+CA C C + G Y+
Sbjct: 1194 QPCQNGGTCIDLVNHFKCSCPPGTR----GLLCEENIDDCARGPHCLNGGQCMDRIGGYS 1249
Query: 178 CSCVEGY 184
C C+ G+
Sbjct: 1250 CRCLPGF 1256
Score = 43.1 bits (100), Expect = 0.006
Identities = 115/494 (23%), Positives = 166/494 (33%), Gaps = 141/494 (28%)
Query: 838 GEALPHICKAGE--FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNH--SCPD--DQF 891
G + H+C+ N H Q G C + DE + N H +C D +
Sbjct: 1113 GVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSY-CEEQLDECASNPCQHGATCSDFIGGY 1171
Query: 892 KCQNNRCIPKRWLCDGANDCGSNEDE-SNQTC-TARTC--QVDQFSCGNGRCIP--RAWL 945
+C+ C+P G N C DE NQ C TC V+ F C C P R L
Sbjct: 1172 RCE---CVPGY---QGVN-CEYEVDECQNQPCQNGGTCIDLVNHFKCS---CPPGTRGLL 1221
Query: 946 CDRE-DDC---------GDQTDEMASCEFPTCEPLTQFV---CKS--GRCISSKWHCDSD 990
C+ DDC G D + +C L F C+ C+S+ +
Sbjct: 1222 CEENIDDCARGPHCLNGGQCMDRIGGY---SCRCLPGFAGERCEGDINECLSNPCSSEGS 1278
Query: 991 DDCGDGSDEVGCV-HSCFDN-----------QFRCSSG---------------RCIPGHW 1023
DC +++ CV S F Q C +G RC PG
Sbjct: 1279 LDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFS 1338
Query: 1024 ACDGDNDCGDFSDEAQINCTKEE--IHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCED 1081
+ CG Q+ C K E +H+ +G +C C +DCE
Sbjct: 1339 GARCQSSCG------QVKCRKGEQCVHTASGP-----RCF-----------CPSPRDCES 1376
Query: 1082 GSDEKGCN--GTIRLCDHKTKFSC-----WSTGRC-------INKAWVCDGDIDCEDQSD 1127
G C G+ +SC +S RC C C D++
Sbjct: 1377 GCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQY-CADKAR 1435
Query: 1128 EDDCDSFLCGPPKHPCANDTSVCL----QPEKLCNGKKDCPDGSDEGYLCDECSLNNGGC 1183
+ CD C H C D C P C+ C D Y+ N C
Sbjct: 1436 DGVCDE-ACN--SHACQWDGGDCSLTMENPWANCSSPLPCWD-----YI-------NNQC 1480
Query: 1184 SNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGW 1243
C+ V + + ++KTC+ YC++H K + C+Q ++ +C GW
Sbjct: 1481 DELCNTVE------CLFDNFECQGNSKTCKYDKYCADHFKDNH-CDQGCNSEEC----GW 1529
Query: 1244 KLDVDGESCTSVDP 1257
DG C + P
Sbjct: 1530 ----DGLDCAADQP 1539
Score = 42.7 bits (99), Expect = 0.008
Identities = 41/142 (28%), Positives = 53/142 (37%), Gaps = 14/142 (9%)
Query: 52 CDGDPDCPDDSDESLDTC-PEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLD----CPDG 106
C D C D C P + C L C +N CV+ Q + V CP G
Sbjct: 465 CQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQ-SNPCVNNGQCVDKVNRFQCLCPPG 523
Query: 107 YDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCKDQ-DECAVYG 163
+ G CQ + +C C KC N C C GF G C++ D C
Sbjct: 524 FT-GPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFT----GVLCEENIDNCDPDP 578
Query: 164 TCSQTCRNTHGSYTCSCVEGYL 185
C++ SYTC C GY+
Sbjct: 579 CHHGQCQDGIDSYTCICNPGYM 600
Score = 42.0 bits (97), Expect = 0.014
Identities = 28/89 (31%), Positives = 40/89 (44%), Gaps = 11/89 (12%)
Query: 102 DCPDGYDEGVHCQELLSNCQQLNCQYK--CTMVRNSTRCYCEDGFEITEDGRSC-KDQDE 158
+C G+ EG C+ + +C CQ C N+ C C + G+ C +D DE
Sbjct: 247 NCLPGF-EGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT----GQFCTEDVDE 301
Query: 159 CAVYGTCSQ---TCRNTHGSYTCSCVEGY 184
C + Q TC N +G Y C CV G+
Sbjct: 302 CLLQPNACQNGGTCANRNGGYGCVCVNGW 330
Score = 41.6 bits (96), Expect = 0.018
Identities = 46/189 (24%), Positives = 69/189 (36%), Gaps = 62/189 (32%)
Query: 32 CDP---GEFLCHDHVTCVSQSWLCDGDPDCP----------------DDSDESLDTCPEE 72
C P G+F D C+ Q C C DD E++D C
Sbjct: 286 CPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCA-- 343
Query: 73 VEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHC------------QELLSNC 120
+C + C+ ++ + CP+G G+ C + L +
Sbjct: 344 --------FASCTPGSTCI--DRVASFSCMCPEG-KAGLLCHLDDACISNPCHKGALCDT 392
Query: 121 QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSC-KDQDECAVYGT--CSQT--CRNTHGS 175
LN QY CT C G++ G C +D DECA+ + C C NT G+
Sbjct: 393 NPLNGQYICT---------CPQGYK----GADCTEDVDECAMANSNPCEHAGKCVNTDGA 439
Query: 176 YTCSCVEGY 184
+ C C++GY
Sbjct: 440 FHCECLKGY 448
Score = 40.8 bits (94), Expect = 0.031
Identities = 62/299 (20%), Positives = 96/299 (32%), Gaps = 37/299 (12%)
Query: 3601 CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD 3660
C ++G G C +G C ++ RC+N C+ L C
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94
Query: 3661 GSDEENCERG-GNICRADEFLCNNSLCKL---HFWVCDGEDDCGDNSDEAPDMCVKFLCP 3716
G E+C+ + C N C + + C + + D C+ C
Sbjct: 95 GFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCA 154
Query: 3717 STRPHRCRNNRI---CLQ--SEQMC-NGIDECGDNSDEDHCGGKLT------------YK 3758
+ N+ CL + Q C ++EC H G L +
Sbjct: 155 NGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT 214
Query: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP-----CG 3813
+ C C+ C+ GD + E C TCE N++ C
Sbjct: 215 GQYCDSLYVPCAPSPCV----NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ 270
Query: 3814 DDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVF-GTCSH--QCINVEGSYKCVC 3869
+ C + CRC P + ED++ECL+ C + C N G Y CVC
Sbjct: 271 NGGVCVDGVNTYNCRCPPQWTGQFCT---EDVDECLLQPNACQNGGTCANRNGGYGCVC 326
Score = 40.0 bits (92), Expect = 0.054
Identities = 45/169 (26%), Positives = 65/169 (38%), Gaps = 24/169 (14%)
Query: 31 LCDPG--EFLCH-DHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVE-IKCPLNHIACLG 86
LCD G C D C+S C C + + TC + + C +N C
Sbjct: 744 LCDAGWVGINCEVDKNECLSNP--CQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDEC-A 800
Query: 87 TNKCVH----LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRN----STRC 138
+N C++ + C Y G +CQ +L+ C C+ + S C
Sbjct: 801 SNPCLNQGTCFDDISGYTCHCVLPYT-GKNCQTVLAPCSPNPCENAAVCKESPNFESYTC 859
Query: 139 YCEDGFEITEDGRSCK-DQDECAVYGTCSQ--TCRNTHGSYTCSCVEGY 184
C G++ G+ C D DEC + C C NT GSY C C G+
Sbjct: 860 LCAPGWQ----GQRCTIDIDEC-ISKPCMNHGLCHNTQGSYMCECPPGF 903
Score = 39.3 bits (90), Expect = 0.091
Identities = 96/492 (19%), Positives = 157/492 (31%), Gaps = 124/492 (25%)
Query: 3280 NNGGC-----SHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWW 3334
N G C + CL PG T C T D CLS + C +D +
Sbjct: 922 NGGSCMDGVNTFSCLCLPGFTGD-KCQT------DMNECLSEPCKNGGTC-SDYVNSYTC 973
Query: 3335 KCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC-----DGENDCGDNSDEL 3389
KC D + ++C E C F GT + + +F C + C +E
Sbjct: 974 KCQAGFDGVHCENNINECTESSC----FNGGTCVDGINSFSCLCPVGFTGSFCLHEINE- 1028
Query: 3390 NCDTHVCLS--------GQFKCT-------KNQKCIPVNL----RCNGQDDCGDEEDERD 3430
C +H CL+ G ++C+ KN + + VNL C + C ++ E
Sbjct: 1029 -CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTL-VNLCSRSPCKNKGTCVQKKAESQ 1086
Query: 3431 CPENS------CSPDYFQCK--TTKHCISKLWVCDEDPDCADASDEANCD------KKTC 3476
C S C C ++ + +C C +A + C C
Sbjct: 1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYC 1146
Query: 3477 GPHEFQCKNNNC--------IPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGD-C 3527
+C +N C +RC+ C NC+ + ++ C NG C
Sbjct: 1147 EEQLDECASNPCQHGATCSDFIGGYRCE----CVPGYQGVNCEYEVDECQNQPCQNGGTC 1202
Query: 3528 VS--SRFWCDGDFDCADGSDERNCETS---CSKDQFRCSNGQCIP-------------AK 3569
+ + F C C G+ CE + C++ + GQC+ A
Sbjct: 1203 IDLVNHFKCS----CPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAG 1258
Query: 3570 WKCDGHED-------------------------CKYGEDEKSCEPASPTCSSREYICASD 3604
+C+G + C+ + CE C +
Sbjct: 1259 ERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGT 1318
Query: 3605 GCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPI----RWLCDGIHDCVD 3660
+++++ C G C + C Q +C+ C+ R C DC
Sbjct: 1319 CAVASNMPDGFICRCPPGFSGARCQSSC--GQVKCRKGEQCVHTASGPRCFCPSPRDCES 1376
Query: 3661 GSDEENCERGGN 3672
G C+ GG+
Sbjct: 1377 GCASSPCQHGGS 1388
Score = 39.3 bits (90), Expect = 0.091
Identities = 48/189 (25%), Positives = 69/189 (36%), Gaps = 31/189 (16%)
Query: 35 GEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK-CPLNHIACLGT---NKC 90
G F H+ C S L +G C D +CP K C C + NK
Sbjct: 1019 GSFCLHEINECSSHPCLNEGT--CVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKG 1076
Query: 91 VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQ----------QLNCQYK--CTMVRNSTRC 138
+ + CP G+ G +C +C + CQ+ C N+ C
Sbjct: 1077 TCVQKKAESQCLCPSGW-AGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC 1135
Query: 139 YCEDGFEITEDGRSCKDQ-DECAVYGTCSQ--TCRNTHGSYTCSCVEGYLMQPDNRSCKA 195
C G+ G C++Q DECA C TC + G Y C CV GY +C+
Sbjct: 1136 QCPLGYT----GSYCEEQLDECAS-NPCQHGATCSDFIGGYRCECVPGY----QGVNCEY 1186
Query: 196 KIEPTDRPP 204
+++ P
Sbjct: 1187 EVDECQNQP 1195
Score = 35.4 bits (80), Expect = 1.3
Identities = 31/134 (23%), Positives = 52/134 (38%), Gaps = 27/134 (20%)
Query: 63 DESLDTCPEEVEIKCPLNHIAC---LGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSN 119
+E++D C + P +H C + + C+ C GY G C + +
Sbjct: 568 EENIDNCDPD-----PCHHGQCQDGIDSYTCI-----------CNPGY-MGAICSDQIDE 610
Query: 120 CQQLNC--QYKCTMVRNSTRCYCEDGFEITEDGRSCK-DQDECAVYGTCSQTCRNTHGSY 176
C C +C + N +C C+ G G +C+ + D+CA C + Y
Sbjct: 611 CYSSPCLNDGRCIDLVNGYQCNCQPG----TSGVNCEINFDDCASNPCIHGICMDGINRY 666
Query: 177 TCSCVEGYLMQPDN 190
+C C G+ Q N
Sbjct: 667 SCVCSPGFTGQRCN 680
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.458
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 205,369,974
Number of Sequences: 37866
Number of extensions: 10843769
Number of successful extensions: 47146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 19130
Number of HSP's gapped (non-prelim): 10716
length of query: 4599
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4476
effective length of database: 13,590,000
effective search space: 60828840000
effective search space used: 60828840000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.