Guide to the Human Genome
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Search of human proteins with 89886477

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|89886477 zinedin isoform 1 [Homo sapiens]
         (753 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|89886477 zinedin isoform 1 [Homo sapiens]                         1526   0.0  
gi|89886480 zinedin isoform 2 [Homo sapiens]                         1519   0.0  
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]             751   0.0  
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]             748   0.0  
gi|51242945 striatin, calmodulin binding protein [Homo sapiens]       707   0.0  
gi|16554629 WD repeat domain 5 [Homo sapiens]                          99   1e-20
gi|16554627 WD repeat domain 5 [Homo sapiens]                          99   1e-20
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]           96   9e-20
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]           96   2e-19
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]           96   2e-19
gi|23199987 WD repeat domain 5B [Homo sapiens]                         89   1e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             87   7e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             87   7e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    86   1e-16
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    84   6e-16
gi|26665869 WD repeat domain 51B [Homo sapiens]                        80   9e-15
gi|32189425 WD repeat domain 69 [Homo sapiens]                         79   1e-14
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [...    79   2e-14
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [...    79   2e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    79   2e-14
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             78   3e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     77   8e-14
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    74   4e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    74   5e-13
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             73   8e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            73   8e-13
gi|19913369 transducin beta-like 3 [Homo sapiens]                      72   2e-12
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               71   3e-12
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       71   3e-12
gi|13376840 WD repeat domain 61 [Homo sapiens]                         71   3e-12

>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 1526 bits (3951), Expect = 0.0
 Identities = 753/753 (100%), Positives = 753/753 (100%)

Query: 1   MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
           MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1   MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60

Query: 61  EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
           EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61  EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120

Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
           LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180

Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
           YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240

Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
           EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300

Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
           PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360

Query: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420
           RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420

Query: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480
           KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD
Sbjct: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480

Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540
           VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL
Sbjct: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540

Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600
           EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS
Sbjct: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600

Query: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660
           TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG
Sbjct: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660

Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720
           IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH
Sbjct: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720

Query: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
           RKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 1519 bits (3933), Expect = 0.0
 Identities = 753/760 (99%), Positives = 753/760 (99%), Gaps = 7/760 (0%)

Query: 1   MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
           MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1   MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60

Query: 61  EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
           EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61  EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120

Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
           LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180

Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
           YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240

Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
           EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300

Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
           PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360

Query: 361 RDVDGLPPKVTGPPPGTPQPRPHE-------DVFIMDTIGGGEVSLGDLADLTVTNDNDL 413
           RDVDGLPPKVTGPPPGTPQPRPHE       DVFIMDTIGGGEVSLGDLADLTVTNDNDL
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420

Query: 414 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 473
           SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA
Sbjct: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480

Query: 474 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 533
           KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP
Sbjct: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540

Query: 534 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 593
           SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP
Sbjct: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600

Query: 594 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
           TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI
Sbjct: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660

Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
           TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC
Sbjct: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720

Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
           VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760


>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
          Length = 713

 Score =  751 bits (1938), Expect = 0.0
 Identities = 415/762 (54%), Positives = 511/762 (67%), Gaps = 80/762 (10%)

Query: 20  LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
           L  G G GP  AAP      GPG      P G G  GGG P      GP AGPE      
Sbjct: 4   LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62

Query: 63  LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
            ++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63  YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122

Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
           YALKQERAKYHKLK+GT+LNQG+ K    E       E+ T  +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182

Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
           L+EVGYTDTILD+RS+RVRSLLG S  E NG+VE              L+GGES   KQ 
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233

Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
            ++IKR++          G VL    FL+N +D D DE++++         +H+  + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283

Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354
            ++ L  ++ D+    D+E+A+ EFDFL + EDGEGA + R  + DG+            
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330

Query: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLS 414
                          +T P  G        D  ++  +G     LGDLADLTVTND D S
Sbjct: 331 -------------EPITFPSGGGKSFIMGSDDVLLSVLG-----LGDLADLTVTNDADYS 372

Query: 415 CDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
            DL  +KDAF+KTWNPK+TLRSH+DG+R+LAFH  +  L+TASED TLKLWNLQK V AK
Sbjct: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432

Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
           K+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I  W +P  S+DPYD Y+P+
Sbjct: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPN 492

Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
           VL+  L GH DAVWGLA+S    +L SCSADGTVR+W+P    P C+CT+    +HG+PT
Sbjct: 493 VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPT 551

Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPL 651
           SV F   +PAH+V SF +G  V+YD+E   +L+ L S+  SG      IN+VVSHP  P+
Sbjct: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPV 611

Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
           TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+K
Sbjct: 612 TITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSK 671

Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
           TCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 672 TCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713


>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
          Length = 797

 Score =  748 bits (1931), Expect = 0.0
 Identities = 426/820 (51%), Positives = 529/820 (64%), Gaps = 112/820 (13%)

Query: 20  LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
           L  G G GP  AAP      GPG      P G G  GGG P      GP AGPE      
Sbjct: 4   LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62

Query: 63  LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
            ++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63  YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122

Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
           YALKQERAKYHKLK+GT+LNQG+ K    E       E+ T  +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182

Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
           L+EVGYTDTILD+RS+RVRSLLG S  E NG+VE              L+GGES   KQ 
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233

Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
            ++IKR++          G VL    FL+N +D D DE++++         +H+  + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283

Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELE------- 347
            ++ L  ++ D+    D+E+A+ EFDFL + EDGEGA + R  + DG+  + +       
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWDKDDLSPTAE 339

Query: 348 ----------------------------SRRVKLQGILADLRDVDGLPPKVTG----PPP 375
                                       + R KL  ++ADL D D LP   +G       
Sbjct: 340 VWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGD-DELPHIPSGIINQSRS 398

Query: 376 GTPQPRPHEDVFIMDT------IGGGE-------------VSLGDLADLTVTNDNDLSCD 416
            + +   HE     +        GGG+             + LGDLADLTVTND D S D
Sbjct: 399 ASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYD 458

Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKN 476
           L  +KDAF+KTWNPK+TLRSH+DG+R+LAFH  +  L+TASED TLKLWNLQK V AKK+
Sbjct: 459 LPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 518

Query: 477 AALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVL 536
           A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I  W +P  S+DPYD Y+P+VL
Sbjct: 519 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 578

Query: 537 SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSV 596
           +  L GH DAVWGLA+S    +L SCSADGTVR+W+P    P C+CT+    +HG+PTSV
Sbjct: 579 AGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPTSV 637

Query: 597 AFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPLTI 653
            F   +PAH+V SF +G  V+YD+E   +L+ L S+  SG      IN+VVSHP  P+TI
Sbjct: 638 DFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTI 697

Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
           TAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+KTC
Sbjct: 698 TAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTC 757

Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
           VQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 758 VQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 797


>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
          Length = 780

 Score =  707 bits (1826), Expect = 0.0
 Identities = 394/795 (49%), Positives = 499/795 (62%), Gaps = 84/795 (10%)

Query: 24  AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80
           AGPG   +   P +  A G GP  +    G G+    A     SLPGILHF+QHEWARFE
Sbjct: 5   AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64

Query: 81  AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140
            E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+
Sbjct: 65  VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124

Query: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200
           LNQG+ K    +       E    +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR
Sbjct: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184

Query: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260
           +LLG S ++    +                  +  +V   E ++K  A     +     S
Sbjct: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229

Query: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320
           VL    FL++   + SDED++ D    +K  +   +      + D  E+ D+++A+ EFD
Sbjct: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289

Query: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349
           FL + E+G+   +  R   DG+  E E +                               
Sbjct: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346

Query: 350 ----RVKLQGILADLRDVDGLP---PKVTGPPPGTPQPRPHEDV---------------- 386
               R KLQ +LA+LRDVD LP   P V  P   +    P  ++                
Sbjct: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406

Query: 387 --FIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 441
             FIM  D     E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI
Sbjct: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466

Query: 442 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 501
           R+LAFH  +  L+TASED TLK+WNLQK   AKK+ +LDVEPI+ FRAH+GPVL V M S
Sbjct: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526

Query: 502 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 561
           N E CYSGG D  I  W   + ++DPYD YDPSVL   L GH DAVWGLA+S   QRL S
Sbjct: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586

Query: 562 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 621
           CSADGT+R+W+ +  +PA L  F    E G+P SV   S++P+H+VASF  G T +++ME
Sbjct: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645

Query: 622 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 678
               +LTLES     ++   QIN+V+SHP  P++ITAH+DR I+F DN TGK +HSMVAH
Sbjct: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705

Query: 679 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 738
           L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK 
Sbjct: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765

Query: 739 LIASAGADALAKVFV 753
            IASAGADALAKVFV
Sbjct: 766 YIASAGADALAKVFV 780


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)

Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484
           K  +  KFTL  H   + S+ F  +   L ++S D  +K+W            A D +  
Sbjct: 32  KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80

Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
                H+  +  VA  S+S    S   D  +  W +                   L+GH 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129

Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
           + V+   F+P S  + S S D +VRIWD  +    CL T P    H  P S    + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184

Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
            IV+S   G   ++D   G  L TL    +     ++ V   PN    + A  D  ++  
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241

Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
           D   GK + +   H +   C+  +     G +++SGS D  + +W+L  K  VQ++    
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297

Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746
           + H + + + ACHP++ +IASA  +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)

Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
           I+ V    +  L ++A DD+ ++  D  +GK + ++  H + V C   +P    ++SGS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           D S+R+W +    C++ + A    H + + AV  +   +LI S+  D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)

Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484
           K  +  KFTL  H   + S+ F  +   L ++S D  +K+W            A D +  
Sbjct: 32  KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80

Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
                H+  +  VA  S+S    S   D  +  W +                   L+GH 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129

Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
           + V+   F+P S  + S S D +VRIWD  +    CL T P    H  P S    + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184

Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
            IV+S   G   ++D   G  L TL    +     ++ V   PN    + A  D  ++  
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241

Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
           D   GK + +   H +   C+  +     G +++SGS D  + +W+L  K  VQ++    
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297

Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746
           + H + + + ACHP++ +IASA  +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)

Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
           I+ V    +  L ++A DD+ ++  D  +GK + ++  H + V C   +P    ++SGS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           D S+R+W +    C++ + A    H + + AV  +   +LI S+  D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198


>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 49/82 (59%), Positives = 59/82 (71%), Gaps = 9/82 (10%)

Query: 83  KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
           K+RWE    + Q         AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7   KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66

Query: 134 KLKFGTDLNQGEKKADVSEQVS 155
           KLK+G +LNQG+ K  + +  S
Sbjct: 67  KLKYGRELNQGDMKPPIYDSDS 88


>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)

Query: 83  KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
           K+RWE    + Q         AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7   KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66

Query: 134 KLKFGTDLNQGEKK 147
           KLK+G +LNQG+ K
Sbjct: 67  KLKYGRELNQGDMK 80


>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)

Query: 83  KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
           K+RWE    + Q         AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7   KSRWETGEVQAQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66

Query: 134 KLKFGTDLNQGEKK 147
           KLK+G +LNQG+ K
Sbjct: 67  KLKYGRELNQGDMK 80


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 79/319 (24%), Positives = 131/319 (41%), Gaps = 37/319 (11%)

Query: 431 KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490
           K TL  H + + S+ F  +   L ++S D  + +W            A D +       H
Sbjct: 34  KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG-----------AYDGKYEKTLYGH 82

Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550
              +  VA  S+S    S   D  +  W +                   L+GH + V+  
Sbjct: 83  NLEISDVAWSSDSSRLVSASDDKTLKLWDVRS-----------GKCLKTLKGHSNYVFCC 131

Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
            F+P S  + S S D TV+IW+  +    CL    T S H  P S    +   + IV+  
Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGK--CL---KTLSAHSDPVSAVHFNCSGSLIVSGS 186

Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670
             G   ++D   G  L TL    +     ++ V   PN    +TA  D  ++  D   G+
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNP---PVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243

Query: 671 PVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEA 727
            + +   H +   C+  +     G +++SGS D  + +W+L  K  VQ++  H     + 
Sbjct: 244 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT----DV 299

Query: 728 IHAVACHPSKALIASAGAD 746
           + + ACHP++ LIASA  +
Sbjct: 300 VISAACHPTENLIASAALE 318



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 47/182 (25%), Positives = 85/182 (46%), Gaps = 9/182 (4%)

Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595
           L   L GH +AV  + FSP  + LAS SAD  + IW              T   H +  S
Sbjct: 33  LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-----KTLYGHNLEIS 87

Query: 596 VAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA 655
               S++ + +V++       L+D+  G  L TL+   +     +     +P   L I+ 
Sbjct: 88  DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN----YVFCCNFNPPSNLIISG 143

Query: 656 HDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQ 715
             D  ++  + +TGK + ++ AH D V+ +  + +G+ ++SGS+D   R+W   +  C++
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203

Query: 716 EI 717
            +
Sbjct: 204 TL 205



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 29/114 (25%), Positives = 61/114 (53%), Gaps = 4/114 (3%)

Query: 639 QINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGS 698
           +I+ V    +    ++A DD+ ++  D R+GK + ++  H + V C   +P    ++SGS
Sbjct: 85  EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144

Query: 699 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
            D ++++W +    C++ ++A    H + + AV  + S +LI S   D L +++
Sbjct: 145 FDETVKIWEVKTGKCLKTLSA----HSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)

Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
           F+ HR  V  V    N++   SG  D+C+  W +            P   ++   GH DA
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63

Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
           V  + FSP+   LAS S D TVRIW P+    + +    TA+      SV F S   + +
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119

Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665
            AS     TV ++       L +L    S     +      P+  L ++A DD+ ++  D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
             + + VHS   H   VT +   P+G  + +   D ++++W +     +Q    H + H 
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229

Query: 726 EAIHAVACHPSKALIASAGADALAKV 751
            A++ ++ HPS   + +A +D+  K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)

Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470
           S S D+    W+ K     +    H D +  + F  S   L + S D T+++W  N++  
Sbjct: 36  SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95

Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530
            T              FRAH   V +V   S+ +   +   D  +  W            
Sbjct: 96  STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132

Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590
                    L  H + V    FSP  + + S S D TV++WD SS      C        
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187

Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650
           G  T V F  +    I A+       ++D+     L   +   ++    +N +  HP+  
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242

Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
             ITA  D  ++ LD   G+ ++++  H    T +A    G +  SG  D  + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)

Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
           +C  +   D   K W+ +   L  HY      +  L+FH S + L+TAS D TLK+ +L 
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259

Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
           +              ++    H+GP   VA     EY  SGG+D  +  WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)

Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
           F+ HR  V  V    N++   SG  D+C+  W +            P   ++   GH DA
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63

Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
           V  + FSP+   LAS S D TVRIW P+    + +    TA+      SV F S   + +
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119

Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665
            AS     TV ++       L +L    S     +      P+  L ++A DD+ ++  D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
             + + VHS   H   VT +   P+G  + +   D ++++W +     +Q    H + H 
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229

Query: 726 EAIHAVACHPSKALIASAGADALAKV 751
            A++ ++ HPS   + +A +D+  K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)

Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470
           S S D+    W+ K     +    H D +  + F  S   L + S D T+++W  N++  
Sbjct: 36  SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95

Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530
            T              FRAH   V +V   S+ +   +   D  +  W            
Sbjct: 96  STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132

Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590
                    L  H + V    FSP  + + S S D TV++WD SS      C        
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187

Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650
           G  T V F  +    I A+       ++D+     L   +   ++    +N +  HP+  
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242

Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
             ITA  D  ++ LD   G+ ++++  H    T +A    G +  SG  D  + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)

Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
           +C  +   D   K W+ +   L  HY      +  L+FH S + L+TAS D TLK+ +L 
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259

Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
           +              ++    H+GP   VA     EY  SGG+D  +  WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 80/341 (23%), Positives = 139/341 (40%), Gaps = 62/341 (18%)

Query: 417 LSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
           +S S+DA  K W+ +      TL+ H D ++ ++F HS   L + S D T+KLW+ Q   
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--- 180

Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531
                     E I     H   V +VA+  N ++  S   D  I  W++         GY
Sbjct: 181 --------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV-------QTGY 225

Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591
                +    GH + V  +  +     +ASCS D TVR+W  ++      C         
Sbjct: 226 CVKTFT----GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE----CKAELREHEH 277

Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651
           V   +++ + E ++   S  +G                E++ S  P            P 
Sbjct: 278 VVECISW-APESSYSSISEATGS---------------ETKKSGKP-----------GPF 310

Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
            ++   D+ I+  D  TG  + ++V H + V  +     G F++S + D +LR+W   NK
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370

Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
            C++ + A    HE  + ++  H +   + +   D   KV+
Sbjct: 371 RCMKTLNA----HEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 70/292 (23%), Positives = 117/292 (40%), Gaps = 52/292 (17%)

Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
           +A   HR PV  V          S   DA I  W            Y+       L+GH 
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-----------YETGDFERTLKGHT 150

Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP- 603
           D+V  ++F  + + LASCSAD T+++WD       C+ T      HG   +V+  +  P 
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFE--CIRTM-----HGHDHNVSSVAIMPN 203

Query: 604 -AHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA--HDDRG 660
             HIV++ R     +++++ G  + T      +G  +  ++V  PNQ  T+ A   +D+ 
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTF-----TGHREWVRMV-RPNQDGTLIASCSNDQT 257

Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPN--------------------GAFLMSGSHD 700
           +R     T +    +  H   V C++  P                     G FL+SGS D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317

Query: 701 CSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
            ++++W +    C+  +      H+  +  V  H     I S   D   +V+
Sbjct: 318 KTIKMWDVSTGMCLMTLVG----HDNWVRGVLFHSGGKFILSCADDKTLRVW 365



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 26/120 (21%), Positives = 42/120 (35%), Gaps = 22/120 (18%)

Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512
           LL+ S D T+K+W++   +            +     H   V  V   S  ++  S   D
Sbjct: 311 LLSGSRDKTIKMWDVSTGMC-----------LMTLVGHDNWVRGVLFHSGGKFILSCADD 359

Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
             +  W            Y        L  H   V  L F  T+  + + S D TV++W+
Sbjct: 360 KTLRVWD-----------YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 90/339 (26%), Positives = 138/339 (40%), Gaps = 47/339 (13%)

Query: 425 KKTWNPKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480
           K  W+P + L      H   +R +A        +T S D T+K+W+L    + K   +L 
Sbjct: 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL- 242

Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540
                    H   V  V + + S Y +S G D  +  W   DL  +        V+ H  
Sbjct: 243 -------TGHISTVRGVIVSTRSPYLFSCGEDKQVKCW---DLEYN-------KVIRH-Y 284

Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH-GVPTSVAFT 599
            GH  AV+GL   PT   L +CS D T RIWD  + +     +  T S H     +V   
Sbjct: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA-----SVHTLSGHTNAVATVRCQ 339

Query: 600 STEPAHIVASFRSGDTV--LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD 657
           + EP  I  S    DT   L+D+  G   +TL +   S    +  VV HP    T  +  
Sbjct: 340 AAEPQIITGSH---DTTIRLWDLVAGKTRVTLTNHKKS----VRAVVLHPRH-YTFASGS 391

Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
              I+      G  + ++  H   +  L V+ +G  L+SG+ + ++ LW        Q +
Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRV 450

Query: 718 TAHRK----KHEEAIHAVACHPSKALIASAGADALAKVF 752
            A  +      E  I A A   S++ + +A AD   KV+
Sbjct: 451 HAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 74/293 (25%), Positives = 117/293 (39%), Gaps = 38/293 (12%)

Query: 420 SKDAFKKTWNPKFTLRS-----HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
           S D F   WN K   R+     H D + S+ F    + L +AS D T++LW   K     
Sbjct: 37  SWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFS 96

Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
           +           F+AH  PV +V   ++ ++  +   D  I  W +          Y   
Sbjct: 97  E-----------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQR 135

Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
            L + L  H   V    FSP  + + SCS D T++IWD ++      C    +   G   
Sbjct: 136 FL-YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFAN 190

Query: 595 SVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
            V F  +     +AS  S  TV ++D+ V   L   +         +N +  HP+    I
Sbjct: 191 FVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGG----VNCISFHPSGNYLI 244

Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
           TA  D  ++ LD   G+ ++++  H   V  ++    G    SG  D  + LW
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 50/265 (18%), Positives = 101/265 (38%), Gaps = 24/265 (9%)

Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
           F+ H+  + ++ +  N +   +   D  +  W            + P   ++   GH D 
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62

Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
           V  + FSP    LAS S D TVR+W P          F     H  P      S +   +
Sbjct: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRG-----KFSEFKAHTAPVRSVDFSADGQFL 117

Query: 607 VASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDN 666
             +       ++ M     L +L          +      P+  L ++  +D+ I+  D 
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRH----THWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173

Query: 667 RTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEE 726
              + V++    +     +  +P+G  + S   D ++++W +     V ++  H + H  
Sbjct: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSG 229

Query: 727 AIHAVACHPSKALIASAGADALAKV 751
            ++ ++ HPS   + +A +D   K+
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 16/111 (14%)

Query: 414 SCDLSDSKDAFKKTWNPKFT-LRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
           +C  S   D   K W+ +   L  HY     G+  ++FH S + L+TAS DGTLK+ +L 
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL- 257

Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
                     L+   I+  + H GPV  V+     E   SGGAD  +  W+
Sbjct: 258 ----------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 4/76 (5%)

Query: 678 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 737
           H  A+T L + PNG  L + S D  L LW+            H+    + + +V   P  
Sbjct: 17  HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72

Query: 738 ALIASAGADALAKVFV 753
            L+ASA  D   ++++
Sbjct: 73  NLLASASRDRTVRLWI 88


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 78/303 (25%), Positives = 134/303 (44%), Gaps = 29/303 (9%)

Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512
           LLTAS    +KL   +      +N+          +AH  P+  VA+  +     +G  D
Sbjct: 54  LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113

Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFS-PTSQRLASCSADGTVRIW 571
                W       D   G +     + LEGH + V+ +AF+ P   ++A+ S D T ++W
Sbjct: 114 RTCKLW-------DTASGEE----LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162

Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSALLTL 629
             S  +  C  TF      G    +   S  P   + +  S DT   L+D++ G  + TL
Sbjct: 163 --SVETGKCYHTF-----RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215

Query: 630 ESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDP 689
             RG S   +I  +  + +    IT   D  +   D  TG+ V+ ++ H   ++  + + 
Sbjct: 216 --RGHSA--EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW 271

Query: 690 NGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALA 749
           + + +++GS D + +LW   N  CV  +T H    +E + +   +  K LIA+A AD  A
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGH---DDEILDSCFDYTGK-LIATASADGTA 327

Query: 750 KVF 752
           ++F
Sbjct: 328 RIF 330



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 68/313 (21%), Positives = 118/313 (37%), Gaps = 37/313 (11%)

Query: 414 SCDLSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQS-ALLTASEDGTLKLWNL 467
           SC ++ S D   K W+        TL  H + + ++AF++     + T S D T KLW++
Sbjct: 105 SCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV 164

Query: 468 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 527
           +             +  H FR H   ++ ++    S    +G  D     W I +     
Sbjct: 165 ETG-----------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208

Query: 528 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 587
                     + L GH   +  L+F+ +  R+ + S D TV +WD  +     +      
Sbjct: 209 ------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI---- 258

Query: 588 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHP 647
             H    S A  + + + I+         L+D   G  + TL         +I       
Sbjct: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD----EILDSCFDY 313

Query: 648 NQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
              L  TA  D   R     T K +  +  H   ++ ++ +P G  L++GS D + R+W 
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373

Query: 708 LDNKTCVQEITAH 720
                C+Q +  H
Sbjct: 374 AQTGQCLQVLEGH 386



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 66/320 (20%), Positives = 129/320 (40%), Gaps = 36/320 (11%)

Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493
           L++H   + ++A + S S  +T S D T KLW+               E ++    HR  
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG-----------EELNTLEGHRNV 136

Query: 494 VLAVAMGS-NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
           V A+A  +   +   +G  D     W +           +     H   GH   +  L+F
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSV-----------ETGKCYHTFRGHTAEIVCLSF 185

Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612
           +P S  +A+ S D T ++WD  +        +          S++F ++    I  SF  
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEE----VYTLRGHSAEIISLSFNTSGDRIITGSF-D 240

Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672
              V++D + G  +  L    +    +I+    + +  L +T   D+  +  D   GK V
Sbjct: 241 HTVVVWDADTGRKVNILIGHCA----EISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296

Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVA 732
            ++  H D +     D  G  + + S D + R++S   + C+ ++    + HE  I  ++
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL----EGHEGEISKIS 352

Query: 733 CHPSKALIASAGADALAKVF 752
            +P    + +  +D  A+++
Sbjct: 353 FNPQGNHLLTGSSDKTARIW 372



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 31/274 (11%)

Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
           T R H   I  L+F+   + + T S D T KLW++Q             E ++  R H  
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220

Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
            +++++  ++ +   +G  D  +  W             D     ++L GH   +   +F
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269

Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612
           +     + + S D T ++WD ++    C+ T     +  + +   +T      I  +   
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKL---IATASAD 324

Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672
           G   ++       +  LE  G  G  +I+++  +P     +T   D+  R  D +TG+ +
Sbjct: 325 GTARIFSAATRKCIAKLE--GHEG--EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380

Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
             +  H D +   A +  G  +++GS D + R+W
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414


>gi|148536855 coatomer protein complex, subunit alpha isoform 1
           [Homo sapiens]
          Length = 1233

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)

Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500
           ++ L+FH  +  +LT+  +G ++LW+ +      K           F  H GPV  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60

Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538
                  SGG D  I  W               D     +  ++ P +LS          
Sbjct: 61  KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120

Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
                    VL GH   V    F PT   + S S D TVR+WD S      L      S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180

Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
               T V    T  A                 V   +L    RG      +N    HP  
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217

Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
           PL ++  DDR ++   ++      V +   H + V+C    P    ++S S D S+R+W 
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277

Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           +  +T VQ     R+ H+     +A HP+  L A AG D    VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)

Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
           +S   D   K WN K     FTL  H D IR+  FHH    +L+AS+D T+++WN Q   
Sbjct: 67  VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126

Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527
                       +     H   V+        +   S   D  +  W I  L   ++ P 
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175

Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574
                          G   +V+ HVLEGH   V   AF PT   + S + D  V+IW  +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634
            S         T   H    S A        I+++       ++DM   + + T      
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288

Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678
               +   + +HPN  L    HD   I F     R    VH  + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334


>gi|148536853 coatomer protein complex, subunit alpha isoform 2
           [Homo sapiens]
          Length = 1224

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)

Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500
           ++ L+FH  +  +LT+  +G ++LW+ +      K           F  H GPV  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60

Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538
                  SGG D  I  W               D     +  ++ P +LS          
Sbjct: 61  KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120

Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
                    VL GH   V    F PT   + S S D TVR+WD S      L      S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180

Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
               T V    T  A                 V   +L    RG      +N    HP  
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217

Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
           PL ++  DDR ++   ++      V +   H + V+C    P    ++S S D S+R+W 
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277

Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           +  +T VQ     R+ H+     +A HP+  L A AG D    VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)

Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
           +S   D   K WN K     FTL  H D IR+  FHH    +L+AS+D T+++WN Q   
Sbjct: 67  VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126

Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527
                       +     H   V+        +   S   D  +  W I  L   ++ P 
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175

Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574
                          G   +V+ HVLEGH   V   AF PT   + S + D  V+IW  +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634
            S         T   H    S A        I+++       ++DM   + + T      
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288

Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678
               +   + +HPN  L    HD   I F     R    VH  + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 28/207 (13%)

Query: 455 TASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC 514
           T S+DGT+KLW+++K              I  F+ +   VLAV     S+   SGG D  
Sbjct: 169 TGSDDGTVKLWDIRKKAA-----------IQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216

Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-- 572
           I  W +             + L++ + GH D+V GL+ S     L S + D TVR+WD  
Sbjct: 217 IKVWDLRQ-----------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265

Query: 573 PSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESR 632
           P +    C+  F   + H    ++   S  P     +  S D  +Y  +  S  +  +  
Sbjct: 266 PFAPKERCVKIFQ-GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324

Query: 633 GSSGPTQINQVVSHPNQPLTITAHDDR 659
           G +G   IN+V  HP++P+ I+A  D+
Sbjct: 325 GHAG--SINEVAFHPDEPIIISASSDK 349



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 25/275 (9%)

Query: 483 PIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEG 542
           PI     H G V       N     S G D  I  W +        D Y        L+G
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----YGDCDNYA------TLKG 107

Query: 543 HGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTE 602
           H  AV  L ++     L S S D TV +WD  +              H    +  + +  
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERV-----KRLKGHTSFVNSCYPARR 162

Query: 603 PAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGI 661
              +V +     TV L+D+   +A+ T ++       Q+  V  +      I+   D  I
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-----YQVLAVTFNDTSDQIISGGIDNDI 217

Query: 662 RFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL----DNKTCVQEI 717
           +  D R  K  ++M  H D+VT L++   G++L+S + D ++R+W +      + CV+  
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277

Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
             +    E+ +   +  P  + IA+  AD    V+
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 70/333 (21%), Positives = 123/333 (36%), Gaps = 58/333 (17%)

Query: 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 489
           P   L  H   +    FH + S L +A  D  + LWN+            D +     + 
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG----------DCDNYATLKG 107

Query: 490 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHV--LEGHGDAV 547
           H G V+ +   ++    +S   D  +  W             D      V  L+GH   V
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVW-------------DSETGERVKRLKGHTSFV 154

Query: 548 ---WGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
              +     P  Q + + S DGTV++WD      A + TF    +     +V F  T   
Sbjct: 155 NSCYPARRGP--QLVCTGSDDGTVKLWD--IRKKAAIQTFQNTYQ---VLAVTFNDTSD- 206

Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
            I++     D  ++D+       T+     S    +  +         ++   D  +R  
Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVW 262

Query: 665 DNRTGKP-----------VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
           D R   P           VH+   +L  + C +  P+G+ + +GS D  + +W   ++  
Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNL--LRC-SWSPDGSKIAAGSADRFVYVWDTTSRRI 319

Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
           + ++      H  +I+ VA HP + +I SA +D
Sbjct: 320 LYKLPG----HAGSINEVAFHPDEPIIISASSD 348



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 25/172 (14%)

Query: 397 VSLGDLADLTVTN--DNDLSC-DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSAL 453
           V+  D +D  ++   DND+   DL  +K  +        T+R H D +  L+     S L
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTY--------TMRGHADSVTGLSLSSEGSYL 250

Query: 454 LTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADA 513
           L+ + D T+++W+++     ++   +    +H F  +   +L  +   +     +G AD 
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGSADR 307

Query: 514 CIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSAD 565
            ++ W          D     +L + L GH  ++  +AF P    + S S+D
Sbjct: 308 FVYVW----------DTTSRRIL-YKLPGHAGSINEVAFHPDEPIIISASSD 348


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%)

Query: 449  SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 508
            SQ  L +ASED T++LW  Q  +  + + A D       R H GPV   +  ++     +
Sbjct: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078

Query: 509  GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 568
            GG D  +  W       D      P ++      H D V G A++  +  L SCS+DG+V
Sbjct: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130

Query: 569  RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 628
             +WDP S               G  ++V+  +    H+V+  R G   ++D + G  L +
Sbjct: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182

Query: 629  LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 681
            + +   SGP         P    QP    L +T   D   R          H+++ H   
Sbjct: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240

Query: 682  VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 738
            V   AV      +++ S D S+RLW +  +   TC+   +A       A+ AVA  P  +
Sbjct: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293

Query: 739  LIAS 742
            +  S
Sbjct: 2294 MAVS 2297



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%)

Query: 408  TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 462
            T DN L   +S S D     W+P+   R      H   + ++A    +  +++ S DGTL
Sbjct: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170

Query: 463  KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 522
            K+W+ Q               + +  AH GP+   A           G++  + +  +  
Sbjct: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218

Query: 523  LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 579
             +      + P ++  +H L GH   V   A S TS  + + S DG+VR+W  P  +   
Sbjct: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274

Query: 580  CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 639
            C+   P +S     T+VA+ + + +  V+  ++G+ +L+  +   A+ T ++ G  G   
Sbjct: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325

Query: 640  INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 691
               + S  +    ++A +      +  R G    ++  HL+ +        T L   P+G
Sbjct: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382

Query: 692  AFLMSGSHDCSL 703
             FL+    D  L
Sbjct: 2383 HFLILAKADLKL 2394



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%)

Query: 436  SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 486
            +H+  + +  F H+   LLTA EDG +++W+           +L + P  +         
Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941

Query: 487  ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 524
                +RA               +G  L VA+ +    + +   SG  D  +  W + + S
Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001

Query: 525  MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 583
            +             +L      V GLA S   + LAS S D TV++W     + P     
Sbjct: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050

Query: 584  FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 640
            FP  +E   H  P S    ST+   +    R    + +D+      + + S  +     +
Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110

Query: 641  NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 700
                +     L I+   D  +   D  +G+ +   + H  AV+ +A       ++S S D
Sbjct: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167

Query: 701  CSLRLW 706
             +L++W
Sbjct: 2168 GTLKVW 2173



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 79/348 (22%), Positives = 130/348 (37%), Gaps = 49/348 (14%)

Query: 426  KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIH 485
            +TW  + ++ S  DGI +  F    +  LTA  DG L+LW+LQ      +  A   +   
Sbjct: 1706 RTWQEEKSVVSGCDGISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITG 1764

Query: 486  AFRAHRGPVLA-VAMGS----------------------NSEYCYSGGADACIHSWKIPD 522
               +    +LA V +G                       N    +  G      SW    
Sbjct: 1765 CCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSW-AGS 1823

Query: 523  LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLC 582
            +S    DG     ++  L   G ++  LAF+     +A    D  V +W  +    A L 
Sbjct: 1824 ISFFQVDGLK---VTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW--AWREGARLA 1878

Query: 583  TFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 642
             FP  + HG   +  F       ++ +   G   ++   +G        RG  G   ++ 
Sbjct: 1879 AFP--AHHGFVAAALFLHA-GCQLLTAGEDGKVQVWSGSLG------RPRGHLGSLSLSP 1929

Query: 643  VVS---HPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA-VDPNGAFLMSGS 698
             +S    P+       +   GIR     +G       A   AV+ LA + P    L+SG+
Sbjct: 1930 ALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGA 1987

Query: 699  HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
             D SL+ W+L  K C  +      + ++ +  +A   S+ L+ASA  D
Sbjct: 1988 EDGSLQGWAL--KECSLQSLWLLSRFQKPVLGLA--TSQELLASASED 2031


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 88/324 (27%)

Query: 451 SALLTASEDGT-LKLWNLQKAVTAKKNAALDVEPIHA---------------------FR 488
           S LL A  D + +KLW+L+      +   +DV  IH                       R
Sbjct: 280 SKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILR 339

Query: 489 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 548
            H GPV +    ++S    S   D  I  W +          +  +VL    +GH   VW
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--------GSFTNTVL---YQGHAYPVW 388

Query: 549 GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVA 608
            L  SP S   AS S D T R+W                         +F  T P  I A
Sbjct: 389 DLDISPYSLYFASGSHDRTARLW-------------------------SFDRTYPLRIYA 423

Query: 609 SFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRT 668
              +                           ++ V  HPN     T   D+ +R    + 
Sbjct: 424 GHLA--------------------------DVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457

Query: 669 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAI 728
           G  V     H   V  LA  PNG +L S   D  L+LW L + T  +E+    + H + I
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL----RGHTDNI 513

Query: 729 HAVACHPSKALIASAGADALAKVF 752
            ++   P   LIASA  D   +V+
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVW 537



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 68/302 (22%), Positives = 105/302 (34%), Gaps = 74/302 (24%)

Query: 413 LSCDLSDSKDAFKKTWNPKFT-LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
           L+CD+ + +D        +   LR H   + S  F    S LL+ SED +++ W+L    
Sbjct: 316 LACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375

Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531
               N  L       ++ H  PV  + +   S Y  SG  D     W            +
Sbjct: 376 ----NTVL-------YQGHAYPVWDLDISPYSLYFASGSHDRTARLW-----------SF 413

Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591
           D +    +  GH   V  + F P S  LA+ S D TVR+W     +   L T       G
Sbjct: 414 DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT----GHRG 469

Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651
              S+AF+                                               PN   
Sbjct: 470 PVLSLAFS-----------------------------------------------PNGKY 482

Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
             +A +D+ ++  D  +G     +  H D +T L   P+   + S S D S+R+W + N 
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542

Query: 712 TC 713
            C
Sbjct: 543 YC 544



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 23/130 (17%)

Query: 400 GDLADLTVT----NDNDLSCDLSDSKDAFKKTW-----NPKFTLRSHYDGIRSLAFHHSQ 450
           G LAD+       N N L+   + S D   + W     N       H   + SLAF  + 
Sbjct: 424 GHLADVDCVKFHPNSNYLA---TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480

Query: 451 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510
             L +A ED  LKLW+L      K+            R H   + ++    +S    S  
Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKE-----------LRGHTDNITSLTFSPDSGLIASAS 529

Query: 511 ADACIHSWKI 520
            D  +  W I
Sbjct: 530 MDNSVRVWDI 539



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 16/64 (25%), Positives = 29/64 (45%)

Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493
           LR H D I SL F      + +AS D ++++W+++    +        E +  +      
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565

Query: 494 VLAV 497
           VL+V
Sbjct: 566 VLSV 569


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 86/343 (25%), Positives = 132/343 (38%), Gaps = 32/343 (9%)

Query: 416 DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKK 475
           D+ + K   + + + KF  +SH +  R   F      L+T S DG +++WN     T K 
Sbjct: 195 DVEEEKFPTQLSRHIKFGQKSHVECAR---FSPDGQYLVTGSVDGFIEVWNF---TTGKI 248

Query: 476 NAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSV 535
              L  +    F      VL +    ++E   +G  D  I  WKI               
Sbjct: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS----------GQC 298

Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595
           L      H   V  L+FS  S ++ S S D T+RI    S       T      H    +
Sbjct: 299 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVN 353

Query: 596 VAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQI--NQVVSHPNQPLT 652
            A T T+  H + S  S  TV +++M+      T +S GS+  T I  N V+  P  P  
Sbjct: 354 EA-TFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412

Query: 653 ITAHDDRGIRFLDNRTGKPVHSMVAHLDA---VTCLAVDPNGAFLMSGSHDCSLRLWSLD 709
               +      + N  G+ V S  +         C A+ P G ++     D  L  +S  
Sbjct: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTV 472

Query: 710 NKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
                + +T H K     +  +A HP + LIA+   D L K++
Sbjct: 473 TGKLERTLTVHEKD----VIGIAHHPHQNLIATYSEDGLLKLW 511



 Score = 37.0 bits (84), Expect = 0.068
 Identities = 35/179 (19%), Positives = 57/179 (31%), Gaps = 51/179 (28%)

Query: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKA----------------VTAKKNAA 478
           R H   +    F      +++AS DGT+K+WN++                  +T      
Sbjct: 346 RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVIL 405

Query: 479 LDVEPIHAFRAHR------------------------GPVLAVAMGSNSEYCYSGGADAC 514
           L   P H    +R                        G  +  A+    E+ Y  G D  
Sbjct: 406 LPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFV 465

Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDP 573
           ++ +                 L   L  H   V G+A  P    +A+ S DG +++W P
Sbjct: 466 LYCFSTVT-----------GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 81/335 (24%), Positives = 123/335 (36%), Gaps = 63/335 (18%)

Query: 422 DAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW----NLQKAVTAKKNA 477
           DA KKT       +   +  +   +H   ++L  A      +LW    +L +A+   + A
Sbjct: 143 DALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVA------RLWIANYSLPRAMKRLEEA 196

Query: 478 ALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD-----------------ACIHS--- 517
            L  E     R  +   L  ++ S + +C   G D                 AC      
Sbjct: 197 RLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCK 256

Query: 518 -WKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ--------RLASCSADGTV 568
            W +PD +           L H L GH   V  + F P S          LASC+ADG+V
Sbjct: 257 LWSVPDCN-----------LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305

Query: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSAL 626
           ++W   S  P        A   G    VA     P+         D    L+D+E    +
Sbjct: 306 KLWSLDSDEPV-------ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358

Query: 627 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA 686
           L  E         +  +  H +  L  T   D   R  D RTG+ +  +  HL  +  + 
Sbjct: 359 LHQEGHSMG----VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414

Query: 687 VDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
             PNG  + +GS D + ++W L  + CV  I AH+
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 69/330 (20%), Positives = 116/330 (35%), Gaps = 80/330 (24%)

Query: 385 DVFIMDTIGGGEVSLGDLA---DLTVTNDNDLSCDLSDSKDAFKKTWN-----PKFTLRS 436
           D  ++ T+ G   ++G +      TV+ D       S + D   K W+     P   +  
Sbjct: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321

Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
           H   +  + +H S   L T   D + +LW+L+             E I     H   V  
Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-----------EEILHQEGHSMGVYD 370

Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556
           +A   +     +GG DA    W +       +           LEGH   ++G+ FSP  
Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF-----------LEGHLKEIYGINFSPNG 419

Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV 616
             +A+ S D T ++WD         C +   +   + T V F   EP H           
Sbjct: 420 YHIATGSGDNTCKVWDLRQRR----CVYTIPAHQNLVTGVKF---EPIH----------- 461

Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676
                 G+ LLT    G+   T   ++ +HP                       P+ ++ 
Sbjct: 462 ------GNFLLT----GAYDNTA--KIWTHPGW--------------------SPLKTLA 489

Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
            H   V  L +  +G  + + S+D + +LW
Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 26/241 (10%)

Query: 512 DACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
           D+C+  W +            P   ++   GH DAV  + FSP+   LAS S D TVRIW
Sbjct: 2   DSCLMVWHMK-----------PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50

Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLE 630
            P+    + +    TA+      SV F S   + + AS     TV ++       L +L 
Sbjct: 51  VPNVKGESTVFRAHTATVR----SVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSL- 103

Query: 631 SRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPN 690
              S     +      P+  L ++A DD+ ++  D  + + VHS   H   VT +   P+
Sbjct: 104 ---SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160

Query: 691 GAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAK 750
           G  + +   D ++++W +     +Q    H + H  A++ ++ HPS   + +A +D+  K
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216

Query: 751 V 751
           +
Sbjct: 217 I 217



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 65/292 (22%), Positives = 108/292 (36%), Gaps = 40/292 (13%)

Query: 422 DAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKAVTAK 474
           D+    W+ K     +    H D +  + F  S   L + S D T+++W  N++   T  
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60

Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
                       FRAH   V +V   S+ +   +   D  +  W                
Sbjct: 61  ------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT-----------HRQ 97

Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
                L  H + V    FSP  + + S S D TV++WD SS      C        G  T
Sbjct: 98  KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVT 153

Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 654
            V F  +    I A+       ++D+     L   +   ++    +N +  HP+    IT
Sbjct: 154 YVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGNYLIT 208

Query: 655 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
           A  D  ++ LD   G+ ++++  H    T +A    G +  SG  D  + +W
Sbjct: 209 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)

Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
           +C  +   D   K W+ +   L  HY      +  L+FH S + L+TAS D TLK+ +L 
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221

Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
           +              ++    H+GP   VA     EY  SGG+D  +  WK
Sbjct: 222 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 85/387 (21%), Positives = 142/387 (36%), Gaps = 86/387 (22%)

Query: 418 SDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
           S S D   + W+     P FT + H   + S+++      L +  ++G + LW+      
Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190

Query: 473 AKKNAA--------LDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLS 524
             +  A        L  EP+HA                  Y  S   D  +  W      
Sbjct: 191 VGRTLAGHSKWITGLSWEPLHA-------------NPECRYVASSSKDGSVRIW------ 231

Query: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTF 584
            D   G        +L GH  +V  L +      L S S D T+++W    +    LC  
Sbjct: 232 -DTTAGR----CERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW---RAHDGVLCR- 281

Query: 585 PTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSS--------G 636
            T   HG   +    ST+ A    +F   +  +   ++  +L  L+ R  S        G
Sbjct: 282 -TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340

Query: 637 PTQ-------------------------------INQVVSHPNQPLTITAHDDRGIRFLD 665
           P +                               INQV+  P+  +  +A  D+ I+  D
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400

Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
            RTGK + S+  H+ AV  +A   +   L+SGS D +L++W +      Q++      H 
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----AQKLAMDLPGHA 456

Query: 726 EAIHAVACHPSKALIASAGADALAKVF 752
           + ++AV   P    +AS G D   +++
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 53/183 (28%), Positives = 84/183 (45%), Gaps = 8/183 (4%)

Query: 540 LEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFT 599
           LEGH +AV  +AFSPT + LAS S D TVR WD S+ +P   C       H V  S+++ 
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC---KGHRHWV-LSISW- 164

Query: 600 STEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD-- 657
           S +   + +  ++G  +L+D   G  +    +  S   T ++    H N      A    
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224

Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
           D  +R  D   G+    +  H  +VTCL    +G  L S S D ++++W   +    + +
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283

Query: 718 TAH 720
             H
Sbjct: 284 QGH 286



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 16/107 (14%)

Query: 418 SDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
           S S D   K W+ +      +LR H   +  +A+      L++ S D TLK+W+++    
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA--- 445

Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
             +  A+D+        H   V AV    + +   SGG D C+  W+
Sbjct: 446 --QKLAMDLP------GHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 14/106 (13%)

Query: 617 LYDMEVGSAL-LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSM 675
           ++D E+ S+L  TLES+      +  +V+    QP  I         F      +   S+
Sbjct: 64  VHDAEIVSSLGKTLESQA----VETEKVLDIIYQPQAI---------FRVRAVTRCTSSL 110

Query: 676 VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
             H +AV  +A  P G +L SGS D ++R W L  +T       HR
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 22/187 (11%)

Query: 450 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI-----HAFRAHRGPVLAVAMGSNSE 504
           +S L+T S+D T+KLW L KA+ +K N A D  PI        R H   + +VA+  N +
Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSK-NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDK 492

Query: 505 YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSA 564
              +G  D     W +P              L  V  GH   +W + FSP  Q LA+ SA
Sbjct: 493 LLATGSQDRTAKLWALPQCQ-----------LLGVFSGHRRGLWCVQFSPMDQVLATASA 541

Query: 565 DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGS 624
           DGT+++W     S  CL TF           VAF S     +++S   G   L+ ++   
Sbjct: 542 DGTIKLWALQDFS--CLKTF--EGHDASVLKVAFVS-RGTQLLSSGSDGLVKLWTIKNNE 596

Query: 625 ALLTLES 631
            + TL++
Sbjct: 597 CVRTLDA 603



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 74/335 (22%), Positives = 127/335 (37%), Gaps = 43/335 (12%)

Query: 454 LTASEDGTLKLWNL---QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510
           LTA + GTL++W     Q   T  +      E  H   AH   V+  A   ++   Y   
Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322

Query: 511 A-----DACIHSWKIPDLS-MDPYDGY------DPSV--------LSHVLEGHGDAVWGL 550
           +         +S ++ D+  + P D +       P +           +L GH D V  L
Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL 382

Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
                    ASC+ D +VRIW  + +         +   H V T V  +  + + +V   
Sbjct: 383 DVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT-VCCSRLKESFLVTG- 440

Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGP-------------TQINQVVSHPNQPLTITAHD 657
            S D  +    +  ALL+  +   +GP               IN V   PN  L  T   
Sbjct: 441 -SQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQ 499

Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
           DR  +       + +     H   + C+   P    L + S D +++LW+L + +C++  
Sbjct: 500 DRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559

Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
               + H+ ++  VA       + S+G+D L K++
Sbjct: 560 ----EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 45/157 (28%), Positives = 60/157 (38%), Gaps = 27/157 (17%)

Query: 420 SKDAFKKTWN-PKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
           S+D   K W  P+  L      H  G+  + F      L TAS DGT+KLW LQ      
Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ------ 551

Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
                D   +  F  H   VL VA  S      S G+D  +  W I +           +
Sbjct: 552 -----DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN-----------N 595

Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
                L+ H D VWGL  S       + ++D  V +W
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 24/140 (17%)

Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
           T R H   I S+A   +   L T S+D T KLW L +            + +  F  HR 
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQC-----------QLLGVFSGHRR 522

Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLS-MDPYDGYDPSVLSHVLEGHGDAVWGLA 551
            +  V      +   +  AD  I  W + D S +  ++G+D SVL             +A
Sbjct: 523 GLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLK------------VA 570

Query: 552 FSPTSQRLASCSADGTVRIW 571
           F     +L S  +DG V++W
Sbjct: 571 FVSRGTQLLSSGSDGLVKLW 590



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 40/356 (11%)

Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
           S + DA  + W+ +       L +HY  + SLAF      +L++  D    +W+LQ +  
Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-SCQ 228

Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYD 532
           A +   +      A      PV  + + S   Y  + G    +  W+        Y    
Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAAS-GQCVYTQAQ 287

Query: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592
           P        G G  +     + T+  + + +AD  + +++  + S      F   SE  +
Sbjct: 288 P-------PGPGQELTHCTLAHTAGVVLTATADHNLLLYE--ARSLRLQKQFAGYSEEVL 338

Query: 593 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP-L 651
              V F   E +H+V +  S    +++++  +  +        G T I   +    +  L
Sbjct: 339 --DVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL------HGHTDIVLALDVFRKGWL 390

Query: 652 TITAHDDRGIR-FLDNRTGKP--VHSMVAHLDAV-TCLAVDPNGAFLMSGSHDCSLRLWS 707
             +   D+ +R +  N+ G+   V     H  +V T        +FL++GS DC+++LW 
Sbjct: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP 450

Query: 708 L-----------DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           L           DN   + +    ++ H++ I++VA  P+  L+A+   D  AK++
Sbjct: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 78/365 (21%), Positives = 119/365 (32%), Gaps = 72/365 (19%)

Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
           H   + ++AF  + + L T   DG +++W++ +               H FR   G V  
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGT-----------HHFRGSPGVVHL 156

Query: 497 VAMGSNSE--YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSP 554
           VA   +      +S   DA I  W + D S              VL  H  AV  LAFS 
Sbjct: 157 VAFHPDPTRLLLFSSATDAAIRVWSLQDRSC-----------LAVLTAHYSAVTSLAFSA 205

Query: 555 TSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV-----PTSVAFTSTEPAHIVAS 609
               + S   D    IWD  S           + E  V     P S     +   + + +
Sbjct: 206 DGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265

Query: 610 FRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSH-PNQPLTITA------HDDRGIR 662
              G   +++   G  + T       G    +  ++H     LT TA      ++ R +R
Sbjct: 266 GDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLR 325

Query: 663 F-----------LDNRTGKPVHSMV-----------------------AHLDAVTCLAVD 688
                       LD R   P  S V                        H D V  L V 
Sbjct: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVF 385

Query: 689 PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK-ALIASAGADA 747
             G    S + D S+R+W + NK       A    H  ++  V C   K + + +   D 
Sbjct: 386 RKGWLFASCAKDQSVRIWRM-NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444

Query: 748 LAKVF 752
             K++
Sbjct: 445 TVKLW 449


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 117/579 (20%), Positives = 220/579 (37%), Gaps = 69/579 (11%)

Query: 184 EVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQ 243
           ++ Y   I D      + + G S  +   +E  +GA      P            +I   
Sbjct: 219 DIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPED----------RILSC 268

Query: 244 IKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDED-------DELDSVQHKKQRVKLPS 296
            K  +  ++G++R+    + +   +  C   DS  +        E+     KK + K   
Sbjct: 269 RKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMK-KARK 327

Query: 297 KALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGI 356
           KA +   + E+E+ +    ++  D +    + + +   +   +  SPH        LQ  
Sbjct: 328 KAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNN 387

Query: 357 LADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCD 416
           L +L  ++          P  P P+P     I  TIGG      D+  L+ ++DN     
Sbjct: 388 LVELYSLN----------PSLPTPQPVRTSRI--TIGGHR---SDVRTLSFSSDN--IAV 430

Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSA--------LLTASEDGTLKLWNLQ 468
           LS + D+ K  WN     RS    IR++   ++  +        ++  ++ G L+L++L 
Sbjct: 431 LSAAADSIK-IWN-----RSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484

Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPY 528
                          +    AH G + ++++  +     +GGAD  +  W    +  +  
Sbjct: 485 SG-----------NLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENS 533

Query: 529 DGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTAS 588
                SV         + V  +++SP  + LA    D TV+I+   +     L  F +  
Sbjct: 534 TQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT-----LKFFLSLY 588

Query: 589 EHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPN 648
            H +P      S + A I       +  ++ ++ G    +L +   S    +  +   P 
Sbjct: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS----VMYLQFVPK 644

Query: 649 QPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708
             L  TA  D  I+  D    + + ++  H   + CLAV P+G +++S SHD SLRLW  
Sbjct: 645 SHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWER 704

Query: 709 DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADA 747
             +  + E     ++  E   +VA     A+      D+
Sbjct: 705 TREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDS 743



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 31/134 (23%), Positives = 59/134 (44%), Gaps = 8/134 (5%)

Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676
           ++D+  G  +L L+        ++  +   P+       ++D  IR     +G+   +  
Sbjct: 49  IWDLRKGEKILILQGLKQ----EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN 104

Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPS 736
            H  A+T L  D  G  L SGS D  + +W + N++ +  +    K H++AI        
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL----KGHKDAITQALFLRE 160

Query: 737 KALIASAGADALAK 750
           K L+ ++G D + K
Sbjct: 161 KNLLVTSGKDTMVK 174



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 25/140 (17%), Positives = 50/140 (35%), Gaps = 22/140 (15%)

Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
           T   H   I +L +      L + S+D  + +W++           ++   ++  + H+ 
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV-----------INESGLYRLKGHKD 150

Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
            +             + G D  +  W +           D       + GH   VWGL  
Sbjct: 151 AITQALFLREKNLLVTSGKDTMVKWWDL-----------DTQHCFKTMVGHRTEVWGLVL 199

Query: 553 SPTSQRLASCSADGTVRIWD 572
               +RL + ++D  +R+WD
Sbjct: 200 LSEEKRLITGASDSELRVWD 219



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 38/170 (22%), Positives = 68/170 (40%), Gaps = 9/170 (5%)

Query: 539 VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 598
           +L+G    V  L  SP    LA    DG++RI+   S          T + H    +   
Sbjct: 60  ILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNV-----TFNGHKAAITTLK 114

Query: 599 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDD 658
                  + +  +  D +++D+   S L  L+    +    I Q +    + L +T+  D
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDA----ITQALFLREKNLLVTSGKD 170

Query: 659 RGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708
             +++ D  T     +MV H   V  L +      L++G+ D  LR+W +
Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 34/138 (24%), Positives = 56/138 (40%), Gaps = 24/138 (17%)

Query: 393 GGGEVSL-GDLADLTVTNDNDLSCDL-SDSKDAFKKTWNP-----KFTLRSHYDGIRSLA 445
           G G V+  G  A +T    + L   L S SKD     W+       + L+ H D I    
Sbjct: 97  GEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQAL 156

Query: 446 FHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFR---AHRGPVLAVAMGSN 502
           F   ++ L+T+ +D  +K W              D++  H F+    HR  V  + + S 
Sbjct: 157 FLREKNLLVTSGKDTMVKWW--------------DLDTQHCFKTMVGHRTEVWGLVLLSE 202

Query: 503 SEYCYSGGADACIHSWKI 520
            +   +G +D+ +  W I
Sbjct: 203 EKRLITGASDSELRVWDI 220


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 70/273 (25%), Positives = 113/273 (41%), Gaps = 36/273 (13%)

Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
           H D +    FH S   L T+S D T+KLW+L K            + I  F  H   V +
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG-----------DCILTFEGHSRAVWS 441

Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556
               S   +  S   D     W +           +       L GH D+V  + F P S
Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDV-----------NSERCRCTLYGHTDSVNSIEFFPFS 490

Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIVASFRS-GD 614
             L + SAD T+ IWD  +     +C     S +G   S+     +P  H++AS  + G 
Sbjct: 491 NTLLTSSADKTLSIWDARTG----IC---EQSLYGHMHSINDAIFDPRGHMIASCDACGV 543

Query: 615 TVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 674
           T L+D      +++++     GP+  N+V    +  +   A  +  I  LD ++G+ +H 
Sbjct: 544 TKLWDFRKLLPIVSID----IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHK 598

Query: 675 MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
           ++ H +    +    +G  L SG  D ++R WS
Sbjct: 599 LMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 38/250 (15%)

Query: 466 NLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSM 525
           NL  +  +   A  D +  + FR H  PV  V+M  + +   S G D     WK+  L  
Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRL---WKVLGLPK 383

Query: 526 DPYDGYDPSVLSHVLEGHGDAVW--GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCT 583
                      + +L G G   W     F P+  +LA+ S D TV++WD       C+ T
Sbjct: 384 ----------CNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILT 431

Query: 584 FPTASE-------HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG 636
           F   S        H     VA +S +            + ++D+       TL     S 
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKT----------SKIWDVNSERCRCTLYGHTDS- 480

Query: 637 PTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 696
              +N +   P     +T+  D+ +   D RTG    S+  H+ ++     DP G  + S
Sbjct: 481 ---VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIAS 537

Query: 697 GSHDCSLRLW 706
                  +LW
Sbjct: 538 CDACGVTKLW 547



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 50/191 (26%), Positives = 72/191 (37%), Gaps = 50/191 (26%)

Query: 418 SDSKDAFKKTWNP-----KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
           S S D   K W+      + TL  H D + S+ F    + LLT+S D TL +W+ +  + 
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512

Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC--IHSWK----IPDLSMD 526
            +           A    RG ++A               DAC     W     +P +S+D
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIA-------------SCDACGVTKLWDFRKLLPIVSID 559

Query: 527 --PYDG----YDPS--VLS------------------HVLEGHGDAVWGLAFSPTSQRLA 560
             P  G    +D S  VL+                  H L GH +    + FS   + L 
Sbjct: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILF 619

Query: 561 SCSADGTVRIW 571
           S  +DGTVR W
Sbjct: 620 SGGSDGTVRTW 630



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 23/113 (20%), Positives = 50/113 (44%), Gaps = 4/113 (3%)

Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
           ++ V   P++ + ++  +DR  + L       + +   H D ++     P+G  L + S 
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414

Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
           D +++LW L    C+     H +    A+ +   H     +AS+  D  +K++
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSR----AVWSCTWHSCGNFVASSSLDKTSKIW 463


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 37/316 (11%)

Query: 435 RSHYDGIRSLAF----HHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490
           ++H D I S+A+      +   ++T S D  +K+W         ++  LD++   +   H
Sbjct: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGH 63

Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550
           +  V++V +        S   DA I  W + +             +  +  G  DA W L
Sbjct: 64  QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQ----------IKSIDAGPVDA-WTL 112

Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
           AFSP SQ LA+ +  G V I+   S        +   +      S+A+ S +  ++ +  
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKE----YSLDTRGKFILSIAY-SPDGKYLASGA 167

Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670
             G   ++D+  G  L TLE  G + P  I  +   P+  L +TA DD  I+  D +   
Sbjct: 168 IDGIINIFDIATGKLLHTLE--GHAMP--IRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223

Query: 671 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHA 730
              ++  H   V  +A  P+    +S S D S+++W +  +TCV         H++ +  
Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF----DHQDQVWG 279

Query: 731 VACHPSKALIASAGAD 746
           V  + + + I S G D
Sbjct: 280 VKYNGNGSKIVSVGDD 295



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 62/297 (20%), Positives = 124/297 (41%), Gaps = 38/297 (12%)

Query: 417 LSDSKDAFKKTW-------NPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQK 469
           ++ S D   K W       + +++L  H  G+ S+   H+     ++S D  ++LW+L+ 
Sbjct: 36  VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95

Query: 470 AVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYD 529
               K+  ++D  P+ A+         +A   +S+Y  +G      H  K+         
Sbjct: 96  G---KQIKSIDAGPVDAW--------TLAFSPDSQYLATG-----THVGKVNIF------ 133

Query: 530 GYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
           G +     + L+  G  +  +A+SP  + LAS + DG + I+D ++          T   
Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK-----LLHTLEG 188

Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
           H +P      S +   +V +   G   +YD++  +   TL    S     +  V   P+ 
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHAS----WVLNVAFCPDD 244

Query: 650 PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
              +++  D+ ++  D  T   VH+   H D V  +  + NG+ ++S   D  + ++
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)

Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
           TL  H   IRSL F      L+TAS+DG +K++++Q A  A                H  
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA-----------GTLSGHAS 233

Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
            VL VA   +  +  S  +D  +  W +                 H    H D VWG+ +
Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDV-----------GTRTCVHTFFDHQDQVWGVKY 282

Query: 553 SPTSQRLASCSADGTVRIWD 572
           +    ++ S   D  + I+D
Sbjct: 283 NGNGSKIVSVGDDQEIHIYD 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,107,496
Number of Sequences: 37866
Number of extensions: 2089725
Number of successful extensions: 29442
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 456
Number of HSP's successfully gapped in prelim test: 766
Number of HSP's that attempted gapping in prelim test: 16932
Number of HSP's gapped (non-prelim): 9565
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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