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Search of human proteins with 89886477
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89886477 zinedin isoform 1 [Homo sapiens]
(753 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89886477 zinedin isoform 1 [Homo sapiens] 1526 0.0
gi|89886480 zinedin isoform 2 [Homo sapiens] 1519 0.0
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 751 0.0
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 748 0.0
gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 707 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 99 1e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 99 1e-20
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 9e-20
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 89 1e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 87 7e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 87 7e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 86 1e-16
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 84 6e-16
gi|26665869 WD repeat domain 51B [Homo sapiens] 80 9e-15
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 1e-14
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 79 2e-14
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 79 2e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 2e-14
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 78 3e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 77 8e-14
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 74 4e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 74 5e-13
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 73 8e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 73 8e-13
gi|19913369 transducin beta-like 3 [Homo sapiens] 72 2e-12
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 71 3e-12
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 71 3e-12
gi|13376840 WD repeat domain 61 [Homo sapiens] 71 3e-12
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 1526 bits (3951), Expect = 0.0
Identities = 753/753 (100%), Positives = 753/753 (100%)
Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
Query: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420
RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420
Query: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480
KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD
Sbjct: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480
Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540
VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL
Sbjct: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540
Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600
EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS
Sbjct: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600
Query: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660
TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG
Sbjct: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660
Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720
IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH
Sbjct: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720
Query: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
RKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 1519 bits (3933), Expect = 0.0
Identities = 753/760 (99%), Positives = 753/760 (99%), Gaps = 7/760 (0%)
Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
Query: 361 RDVDGLPPKVTGPPPGTPQPRPHE-------DVFIMDTIGGGEVSLGDLADLTVTNDNDL 413
RDVDGLPPKVTGPPPGTPQPRPHE DVFIMDTIGGGEVSLGDLADLTVTNDNDL
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420
Query: 414 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 473
SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA
Sbjct: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480
Query: 474 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 533
KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP
Sbjct: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540
Query: 534 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 593
SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP
Sbjct: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600
Query: 594 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI
Sbjct: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC
Sbjct: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 751 bits (1938), Expect = 0.0
Identities = 415/762 (54%), Positives = 511/762 (67%), Gaps = 80/762 (10%)
Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330
Query: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLS 414
+T P G D ++ +G LGDLADLTVTND D S
Sbjct: 331 -------------EPITFPSGGGKSFIMGSDDVLLSVLG-----LGDLADLTVTNDADYS 372
Query: 415 CDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V AK
Sbjct: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432
Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
K+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y+P+
Sbjct: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPN 492
Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG+PT
Sbjct: 493 VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPT 551
Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPL 651
SV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP P+
Sbjct: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPV 611
Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+K
Sbjct: 612 TITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSK 671
Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
TCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 672 TCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 748 bits (1931), Expect = 0.0
Identities = 426/820 (51%), Positives = 529/820 (64%), Gaps = 112/820 (13%)
Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELE------- 347
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+ + +
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWDKDDLSPTAE 339
Query: 348 ----------------------------SRRVKLQGILADLRDVDGLPPKVTG----PPP 375
+ R KL ++ADL D D LP +G
Sbjct: 340 VWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGD-DELPHIPSGIINQSRS 398
Query: 376 GTPQPRPHEDVFIMDT------IGGGE-------------VSLGDLADLTVTNDNDLSCD 416
+ + HE + GGG+ + LGDLADLTVTND D S D
Sbjct: 399 ASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYD 458
Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKN 476
L +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V AKK+
Sbjct: 459 LPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 518
Query: 477 AALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVL 536
A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y+P+VL
Sbjct: 519 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 578
Query: 537 SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSV 596
+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG+PTSV
Sbjct: 579 AGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPTSV 637
Query: 597 AFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPLTI 653
F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP P+TI
Sbjct: 638 DFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTI 697
Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
TAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+KTC
Sbjct: 698 TAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTC 757
Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
VQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 758 VQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 797
>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
Length = 780
Score = 707 bits (1826), Expect = 0.0
Identities = 394/795 (49%), Positives = 499/795 (62%), Gaps = 84/795 (10%)
Query: 24 AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80
AGPG + P + A G GP + G G+ A SLPGILHF+QHEWARFE
Sbjct: 5 AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64
Query: 81 AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140
E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+
Sbjct: 65 VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124
Query: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200
LNQG+ K + E +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR
Sbjct: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184
Query: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260
+LLG S ++ + + +V E ++K A + S
Sbjct: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229
Query: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320
VL FL++ + SDED++ D +K + + + D E+ D+++A+ EFD
Sbjct: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289
Query: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349
FL + E+G+ + R DG+ E E +
Sbjct: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346
Query: 350 ----RVKLQGILADLRDVDGLP---PKVTGPPPGTPQPRPHEDV---------------- 386
R KLQ +LA+LRDVD LP P V P + P ++
Sbjct: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406
Query: 387 --FIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 441
FIM D E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI
Sbjct: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466
Query: 442 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 501
R+LAFH + L+TASED TLK+WNLQK AKK+ +LDVEPI+ FRAH+GPVL V M S
Sbjct: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526
Query: 502 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 561
N E CYSGG D I W + ++DPYD YDPSVL L GH DAVWGLA+S QRL S
Sbjct: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586
Query: 562 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 621
CSADGT+R+W+ + +PA L F E G+P SV S++P+H+VASF G T +++ME
Sbjct: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645
Query: 622 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 678
+LTLES ++ QIN+V+SHP P++ITAH+DR I+F DN TGK +HSMVAH
Sbjct: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705
Query: 679 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 738
L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK
Sbjct: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765
Query: 739 LIASAGADALAKVFV 753
IASAGADALAKVFV
Sbjct: 766 YIASAGADALAKVFV 780
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)
Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484
K + KFTL H + S+ F + L ++S D +K+W A D +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80
Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
H+ + VA S+S S D + W + L+GH
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129
Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
+ V+ F+P S + S S D +VRIWD + CL T P H P S + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184
Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
IV+S G ++D G L TL + ++ V PN + A D ++
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241
Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
D GK + + H + C+ + G +++SGS D + +W+L K VQ++
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297
Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746
+ H + + + ACHP++ +IASA +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
D S+R+W + C++ + A H + + AV + +LI S+ D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)
Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484
K + KFTL H + S+ F + L ++S D +K+W A D +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80
Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
H+ + VA S+S S D + W + L+GH
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129
Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
+ V+ F+P S + S S D +VRIWD + CL T P H P S + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184
Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
IV+S G ++D G L TL + ++ V PN + A D ++
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241
Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
D GK + + H + C+ + G +++SGS D + +W+L K VQ++
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297
Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746
+ H + + + ACHP++ +IASA +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
D S+R+W + C++ + A H + + AV + +LI S+ D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 96.3 bits (238), Expect = 9e-20
Identities = 49/82 (59%), Positives = 59/82 (71%), Gaps = 9/82 (10%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKKADVSEQVS 155
KLK+G +LNQG+ K + + S
Sbjct: 67 KLKYGRELNQGDMKPPIYDSDS 88
>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 95.5 bits (236), Expect = 2e-19
Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKK 147
KLK+G +LNQG+ K
Sbjct: 67 KLKYGRELNQGDMK 80
>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 95.5 bits (236), Expect = 2e-19
Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKK 147
KLK+G +LNQG+ K
Sbjct: 67 KLKYGRELNQGDMK 80
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 89.0 bits (219), Expect = 1e-17
Identities = 79/319 (24%), Positives = 131/319 (41%), Gaps = 37/319 (11%)
Query: 431 KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490
K TL H + + S+ F + L ++S D + +W A D + H
Sbjct: 34 KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG-----------AYDGKYEKTLYGH 82
Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550
+ VA S+S S D + W + L+GH + V+
Sbjct: 83 NLEISDVAWSSDSSRLVSASDDKTLKLWDVRS-----------GKCLKTLKGHSNYVFCC 131
Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
F+P S + S S D TV+IW+ + CL T S H P S + + IV+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGK--CL---KTLSAHSDPVSAVHFNCSGSLIVSGS 186
Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670
G ++D G L TL + ++ V PN +TA D ++ D G+
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNP---PVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Query: 671 PVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEA 727
+ + H + C+ + G +++SGS D + +W+L K VQ++ H +
Sbjct: 244 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT----DV 299
Query: 728 IHAVACHPSKALIASAGAD 746
+ + ACHP++ LIASA +
Sbjct: 300 VISAACHPTENLIASAALE 318
Score = 67.0 bits (162), Expect = 6e-11
Identities = 47/182 (25%), Positives = 85/182 (46%), Gaps = 9/182 (4%)
Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595
L L GH +AV + FSP + LAS SAD + IW T H + S
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-----KTLYGHNLEIS 87
Query: 596 VAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA 655
S++ + +V++ L+D+ G L TL+ + + +P L I+
Sbjct: 88 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN----YVFCCNFNPPSNLIISG 143
Query: 656 HDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQ 715
D ++ + +TGK + ++ AH D V+ + + +G+ ++SGS+D R+W + C++
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 716 EI 717
+
Sbjct: 204 TL 205
Score = 56.2 bits (134), Expect = 1e-07
Identities = 29/114 (25%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 639 QINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGS 698
+I+ V + ++A DD+ ++ D R+GK + ++ H + V C +P ++SGS
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 699 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
D ++++W + C++ ++A H + + AV + S +LI S D L +++
Sbjct: 145 FDETVKIWEVKTGKCLKTLSA----HSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 86.7 bits (213), Expect = 7e-17
Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)
Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
F+ HR V V N++ SG D+C+ W + P ++ GH DA
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63
Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + +
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119
Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665
AS TV ++ L +L S + P+ L ++A DD+ ++ D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
+ + VHS H VT + P+G + + D ++++W + +Q H + H
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229
Query: 726 EAIHAVACHPSKALIASAGADALAKV 751
A++ ++ HPS + +A +D+ K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)
Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470
S S D+ W+ K + H D + + F S L + S D T+++W N++
Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95
Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530
T FRAH V +V S+ + + D + W
Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132
Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590
L H + V FSP + + S S D TV++WD SS C
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187
Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650
G T V F + I A+ ++D+ L + ++ +N + HP+
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242
Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
ITA D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 86.7 bits (213), Expect = 7e-17
Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)
Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
F+ HR V V N++ SG D+C+ W + P ++ GH DA
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63
Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + +
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119
Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665
AS TV ++ L +L S + P+ L ++A DD+ ++ D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
+ + VHS H VT + P+G + + D ++++W + +Q H + H
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229
Query: 726 EAIHAVACHPSKALIASAGADALAKV 751
A++ ++ HPS + +A +D+ K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)
Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470
S S D+ W+ K + H D + + F S L + S D T+++W N++
Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95
Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530
T FRAH V +V S+ + + D + W
Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132
Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590
L H + V FSP + + S S D TV++WD SS C
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187
Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650
G T V F + I A+ ++D+ L + ++ +N + HP+
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242
Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
ITA D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 86.3 bits (212), Expect = 1e-16
Identities = 80/341 (23%), Positives = 139/341 (40%), Gaps = 62/341 (18%)
Query: 417 LSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
+S S+DA K W+ + TL+ H D ++ ++F HS L + S D T+KLW+ Q
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--- 180
Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531
E I H V +VA+ N ++ S D I W++ GY
Sbjct: 181 --------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV-------QTGY 225
Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591
+ GH + V + + +ASCS D TVR+W ++ C
Sbjct: 226 CVKTFT----GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE----CKAELREHEH 277
Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651
V +++ + E ++ S +G E++ S P P
Sbjct: 278 VVECISW-APESSYSSISEATGS---------------ETKKSGKP-----------GPF 310
Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
++ D+ I+ D TG + ++V H + V + G F++S + D +LR+W NK
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
C++ + A HE + ++ H + + + D KV+
Sbjct: 371 RCMKTLNA----HEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 74.7 bits (182), Expect = 3e-13
Identities = 70/292 (23%), Positives = 117/292 (40%), Gaps = 52/292 (17%)
Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544
+A HR PV V S DA I W Y+ L+GH
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-----------YETGDFERTLKGHT 150
Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP- 603
D+V ++F + + LASCSAD T+++WD C+ T HG +V+ + P
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFE--CIRTM-----HGHDHNVSSVAIMPN 203
Query: 604 -AHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA--HDDRG 660
HIV++ R +++++ G + T +G + ++V PNQ T+ A +D+
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTF-----TGHREWVRMV-RPNQDGTLIASCSNDQT 257
Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPN--------------------GAFLMSGSHD 700
+R T + + H V C++ P G FL+SGS D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 701 CSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
++++W + C+ + H+ + V H I S D +V+
Sbjct: 318 KTIKMWDVSTGMCLMTLVG----HDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 31.6 bits (70), Expect = 2.8
Identities = 26/120 (21%), Positives = 42/120 (35%), Gaps = 22/120 (18%)
Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512
LL+ S D T+K+W++ + + H V V S ++ S D
Sbjct: 311 LLSGSRDKTIKMWDVSTGMC-----------LMTLVGHDNWVRGVLFHSGGKFILSCADD 359
Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
+ W Y L H V L F T+ + + S D TV++W+
Sbjct: 360 KTLRVWD-----------YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 83.6 bits (205), Expect = 6e-16
Identities = 90/339 (26%), Positives = 138/339 (40%), Gaps = 47/339 (13%)
Query: 425 KKTWNPKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480
K W+P + L H +R +A +T S D T+K+W+L + K +L
Sbjct: 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL- 242
Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540
H V V + + S Y +S G D + W DL + V+ H
Sbjct: 243 -------TGHISTVRGVIVSTRSPYLFSCGEDKQVKCW---DLEYN-------KVIRH-Y 284
Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH-GVPTSVAFT 599
GH AV+GL PT L +CS D T RIWD + + + T S H +V
Sbjct: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA-----SVHTLSGHTNAVATVRCQ 339
Query: 600 STEPAHIVASFRSGDTV--LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD 657
+ EP I S DT L+D+ G +TL + S + VV HP T +
Sbjct: 340 AAEPQIITGSH---DTTIRLWDLVAGKTRVTLTNHKKS----VRAVVLHPRH-YTFASGS 391
Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
I+ G + ++ H + L V+ +G L+SG+ + ++ LW Q +
Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRV 450
Query: 718 TAHRK----KHEEAIHAVACHPSKALIASAGADALAKVF 752
A + E I A A S++ + +A AD KV+
Sbjct: 451 HAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 79.7 bits (195), Expect = 9e-15
Identities = 74/293 (25%), Positives = 117/293 (39%), Gaps = 38/293 (12%)
Query: 420 SKDAFKKTWNPKFTLRS-----HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
S D F WN K R+ H D + S+ F + L +AS D T++LW K
Sbjct: 37 SWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFS 96
Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
+ F+AH PV +V ++ ++ + D I W + Y
Sbjct: 97 E-----------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQR 135
Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
L + L H V FSP + + SCS D T++IWD ++ C + G
Sbjct: 136 FL-YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFAN 190
Query: 595 SVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
V F + +AS S TV ++D+ V L + +N + HP+ I
Sbjct: 191 FVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGG----VNCISFHPSGNYLI 244
Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
TA D ++ LD G+ ++++ H V ++ G SG D + LW
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/265 (18%), Positives = 101/265 (38%), Gaps = 24/265 (9%)
Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546
F+ H+ + ++ + N + + D + W + P ++ GH D
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62
Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606
V + FSP LAS S D TVR+W P F H P S + +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRG-----KFSEFKAHTAPVRSVDFSADGQFL 117
Query: 607 VASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDN 666
+ ++ M L +L + P+ L ++ +D+ I+ D
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRH----THWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 667 RTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEE 726
+ V++ + + +P+G + S D ++++W + V ++ H + H
Sbjct: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSG 229
Query: 727 AIHAVACHPSKALIASAGADALAKV 751
++ ++ HPS + +A +D K+
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 16/111 (14%)
Query: 414 SCDLSDSKDAFKKTWNPKFT-LRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
+C S D K W+ + L HY G+ ++FH S + L+TAS DGTLK+ +L
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL- 257
Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
L+ I+ + H GPV V+ E SGGAD + W+
Sbjct: 258 ----------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 35.8 bits (81), Expect = 0.15
Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 678 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 737
H A+T L + PNG L + S D L LW+ H+ + + +V P
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72
Query: 738 ALIASAGADALAKVFV 753
L+ASA D ++++
Sbjct: 73 NLLASASRDRTVRLWI 88
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.3 bits (194), Expect = 1e-14
Identities = 78/303 (25%), Positives = 134/303 (44%), Gaps = 29/303 (9%)
Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512
LLTAS +KL + +N+ +AH P+ VA+ + +G D
Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113
Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFS-PTSQRLASCSADGTVRIW 571
W D G + + LEGH + V+ +AF+ P ++A+ S D T ++W
Sbjct: 114 RTCKLW-------DTASGEE----LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSALLTL 629
S + C TF G + S P + + S DT L+D++ G + TL
Sbjct: 163 --SVETGKCYHTF-----RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 630 ESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDP 689
RG S +I + + + IT D + D TG+ V+ ++ H ++ + +
Sbjct: 216 --RGHSA--EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW 271
Query: 690 NGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALA 749
+ + +++GS D + +LW N CV +T H +E + + + K LIA+A AD A
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGH---DDEILDSCFDYTGK-LIATASADGTA 327
Query: 750 KVF 752
++F
Sbjct: 328 RIF 330
Score = 74.7 bits (182), Expect = 3e-13
Identities = 68/313 (21%), Positives = 118/313 (37%), Gaps = 37/313 (11%)
Query: 414 SCDLSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQS-ALLTASEDGTLKLWNL 467
SC ++ S D K W+ TL H + + ++AF++ + T S D T KLW++
Sbjct: 105 SCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV 164
Query: 468 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 527
+ + H FR H ++ ++ S +G D W I +
Sbjct: 165 ETG-----------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208
Query: 528 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 587
+ L GH + L+F+ + R+ + S D TV +WD + +
Sbjct: 209 ------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI---- 258
Query: 588 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHP 647
H S A + + + I+ L+D G + TL +I
Sbjct: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD----EILDSCFDY 313
Query: 648 NQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
L TA D R T K + + H ++ ++ +P G L++GS D + R+W
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 708 LDNKTCVQEITAH 720
C+Q + H
Sbjct: 374 AQTGQCLQVLEGH 386
Score = 72.8 bits (177), Expect = 1e-12
Identities = 66/320 (20%), Positives = 129/320 (40%), Gaps = 36/320 (11%)
Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493
L++H + ++A + S S +T S D T KLW+ E ++ HR
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG-----------EELNTLEGHRNV 136
Query: 494 VLAVAMGS-NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
V A+A + + +G D W + + H GH + L+F
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSV-----------ETGKCYHTFRGHTAEIVCLSF 185
Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612
+P S +A+ S D T ++WD + + S++F ++ I SF
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEE----VYTLRGHSAEIISLSFNTSGDRIITGSF-D 240
Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672
V++D + G + L + +I+ + + L +T D+ + D GK V
Sbjct: 241 HTVVVWDADTGRKVNILIGHCA----EISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVA 732
++ H D + D G + + S D + R++S + C+ ++ + HE I ++
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL----EGHEGEISKIS 352
Query: 733 CHPSKALIASAGADALAKVF 752
+P + + +D A+++
Sbjct: 353 FNPQGNHLLTGSSDKTARIW 372
Score = 70.1 bits (170), Expect = 7e-12
Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 31/274 (11%)
Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
T R H I L+F+ + + T S D T KLW++Q E ++ R H
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220
Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
+++++ ++ + +G D + W D ++L GH + +F
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269
Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612
+ + + S D T ++WD ++ C+ T + + + +T I +
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKL---IATASAD 324
Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672
G ++ + LE G G +I+++ +P +T D+ R D +TG+ +
Sbjct: 325 GTARIFSAATRKCIAKLE--GHEG--EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
+ H D + A + G +++GS D + R+W
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 79.0 bits (193), Expect = 2e-14
Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)
Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500
++ L+FH + +LT+ +G ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538
SGG D I W D + ++ P +LS
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
VL GH V F PT + S S D TVR+WD S L S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
T V T A V +L RG +N HP
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217
Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
+ +T VQ R+ H+ +A HP+ L A AG D VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)
Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
+S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527
+ H V+ + S D + W I L ++ P
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574
G +V+ HVLEGH V AF PT + S + D V+IW +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634
S T H S A I+++ ++DM + + T
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288
Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678
+ + +HPN L HD I F R VH + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 79.0 bits (193), Expect = 2e-14
Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)
Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500
++ L+FH + +LT+ +G ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538
SGG D I W D + ++ P +LS
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
VL GH V F PT + S S D TVR+WD S L S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
T V T A V +L RG +N HP
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217
Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
+ +T VQ R+ H+ +A HP+ L A AG D VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)
Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
+S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527
+ H V+ + S D + W I L ++ P
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574
G +V+ HVLEGH V AF PT + S + D V+IW +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634
S T H S A I+++ ++DM + + T
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288
Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678
+ + +HPN L HD I F R VH + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 78.6 bits (192), Expect = 2e-14
Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 28/207 (13%)
Query: 455 TASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC 514
T S+DGT+KLW+++K I F+ + VLAV S+ SGG D
Sbjct: 169 TGSDDGTVKLWDIRKKAA-----------IQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-- 572
I W + + L++ + GH D+V GL+ S L S + D TVR+WD
Sbjct: 217 IKVWDLRQ-----------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Query: 573 PSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESR 632
P + C+ F + H ++ S P + S D +Y + S + +
Sbjct: 266 PFAPKERCVKIFQ-GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324
Query: 633 GSSGPTQINQVVSHPNQPLTITAHDDR 659
G +G IN+V HP++P+ I+A D+
Sbjct: 325 GHAG--SINEVAFHPDEPIIISASSDK 349
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 25/275 (9%)
Query: 483 PIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEG 542
PI H G V N S G D I W + D Y L+G
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----YGDCDNYA------TLKG 107
Query: 543 HGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTE 602
H AV L ++ L S S D TV +WD + H + + +
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERV-----KRLKGHTSFVNSCYPARR 162
Query: 603 PAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGI 661
+V + TV L+D+ +A+ T ++ Q+ V + I+ D I
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-----YQVLAVTFNDTSDQIISGGIDNDI 217
Query: 662 RFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL----DNKTCVQEI 717
+ D R K ++M H D+VT L++ G++L+S + D ++R+W + + CV+
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
+ E+ + + P + IA+ AD V+
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/333 (21%), Positives = 123/333 (36%), Gaps = 58/333 (17%)
Query: 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 489
P L H + FH + S L +A D + LWN+ D + +
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG----------DCDNYATLKG 107
Query: 490 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHV--LEGHGDAV 547
H G V+ + ++ +S D + W D V L+GH V
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVW-------------DSETGERVKRLKGHTSFV 154
Query: 548 ---WGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604
+ P Q + + S DGTV++WD A + TF + +V F T
Sbjct: 155 NSCYPARRGP--QLVCTGSDDGTVKLWD--IRKKAAIQTFQNTYQ---VLAVTFNDTSD- 206
Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664
I++ D ++D+ T+ S + + ++ D +R
Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVW 262
Query: 665 DNRTGKP-----------VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
D R P VH+ +L + C + P+G+ + +GS D + +W ++
Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNL--LRC-SWSPDGSKIAAGSADRFVYVWDTTSRRI 319
Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
+ ++ H +I+ VA HP + +I SA +D
Sbjct: 320 LYKLPG----HAGSINEVAFHPDEPIIISASSD 348
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 397 VSLGDLADLTVTN--DNDLSC-DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSAL 453
V+ D +D ++ DND+ DL +K + T+R H D + L+ S L
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTY--------TMRGHADSVTGLSLSSEGSYL 250
Query: 454 LTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADA 513
L+ + D T+++W+++ ++ + +H F + +L + + +G AD
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGSADR 307
Query: 514 CIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSAD 565
++ W D +L + L GH ++ +AF P + S S+D
Sbjct: 308 FVYVW----------DTTSRRIL-YKLPGHAGSINEVAFHPDEPIIISASSD 348
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 78.2 bits (191), Expect = 3e-14
Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%)
Query: 449 SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 508
SQ L +ASED T++LW Q + + + A D R H GPV + ++ +
Sbjct: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
Query: 509 GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 568
GG D + W D P ++ H D V G A++ + L SCS+DG+V
Sbjct: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130
Query: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 628
+WDP S G ++V+ + H+V+ R G ++D + G L +
Sbjct: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182
Query: 629 LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 681
+ + SGP P QP L +T D R H+++ H
Sbjct: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
Query: 682 VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 738
V AV +++ S D S+RLW + + TC+ +A A+ AVA P +
Sbjct: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293
Query: 739 LIAS 742
+ S
Sbjct: 2294 MAVS 2297
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%)
Query: 408 TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 462
T DN L +S S D W+P+ R H + ++A + +++ S DGTL
Sbjct: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170
Query: 463 KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 522
K+W+ Q + + AH GP+ A G++ + + +
Sbjct: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218
Query: 523 LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 579
+ + P ++ +H L GH V A S TS + + S DG+VR+W P +
Sbjct: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274
Query: 580 CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 639
C+ P +S T+VA+ + + + V+ ++G+ +L+ + A+ T ++ G G
Sbjct: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325
Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 691
+ S + ++A + + R G ++ HL+ + T L P+G
Sbjct: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382
Query: 692 AFLMSGSHDCSL 703
FL+ D L
Sbjct: 2383 HFLILAKADLKL 2394
Score = 46.2 bits (108), Expect = 1e-04
Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%)
Query: 436 SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 486
+H+ + + F H+ LLTA EDG +++W+ +L + P +
Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
Query: 487 ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 524
+RA +G L VA+ + + + SG D + W + + S
Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001
Query: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 583
+ +L V GLA S + LAS S D TV++W + P
Sbjct: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050
Query: 584 FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 640
FP +E H P S ST+ + R + +D+ + + S + +
Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
Query: 641 NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 700
+ L I+ D + D +G+ + + H AV+ +A ++S S D
Sbjct: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167
Query: 701 CSLRLW 706
+L++W
Sbjct: 2168 GTLKVW 2173
Score = 33.9 bits (76), Expect = 0.57
Identities = 79/348 (22%), Positives = 130/348 (37%), Gaps = 49/348 (14%)
Query: 426 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIH 485
+TW + ++ S DGI + F + LTA DG L+LW+LQ + A +
Sbjct: 1706 RTWQEEKSVVSGCDGISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITG 1764
Query: 486 AFRAHRGPVLA-VAMGS----------------------NSEYCYSGGADACIHSWKIPD 522
+ +LA V +G N + G SW
Sbjct: 1765 CCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSW-AGS 1823
Query: 523 LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLC 582
+S DG ++ L G ++ LAF+ +A D V +W + A L
Sbjct: 1824 ISFFQVDGLK---VTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW--AWREGARLA 1878
Query: 583 TFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 642
FP + HG + F ++ + G ++ +G RG G ++
Sbjct: 1879 AFP--AHHGFVAAALFLHA-GCQLLTAGEDGKVQVWSGSLG------RPRGHLGSLSLSP 1929
Query: 643 VVS---HPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA-VDPNGAFLMSGS 698
+S P+ + GIR +G A AV+ LA + P L+SG+
Sbjct: 1930 ALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGA 1987
Query: 699 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
D SL+ W+L K C + + ++ + +A S+ L+ASA D
Sbjct: 1988 EDGSLQGWAL--KECSLQSLWLLSRFQKPVLGLA--TSQELLASASED 2031
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.6 bits (187), Expect = 8e-14
Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 88/324 (27%)
Query: 451 SALLTASEDGT-LKLWNLQKAVTAKKNAALDVEPIHA---------------------FR 488
S LL A D + +KLW+L+ + +DV IH R
Sbjct: 280 SKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILR 339
Query: 489 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 548
H GPV + ++S S D I W + + +VL +GH VW
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--------GSFTNTVL---YQGHAYPVW 388
Query: 549 GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVA 608
L SP S AS S D T R+W +F T P I A
Sbjct: 389 DLDISPYSLYFASGSHDRTARLW-------------------------SFDRTYPLRIYA 423
Query: 609 SFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRT 668
+ ++ V HPN T D+ +R +
Sbjct: 424 GHLA--------------------------DVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 669 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAI 728
G V H V LA PNG +L S D L+LW L + T +E+ + H + I
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL----RGHTDNI 513
Query: 729 HAVACHPSKALIASAGADALAKVF 752
++ P LIASA D +V+
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVW 537
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/302 (22%), Positives = 105/302 (34%), Gaps = 74/302 (24%)
Query: 413 LSCDLSDSKDAFKKTWNPKFT-LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471
L+CD+ + +D + LR H + S F S LL+ SED +++ W+L
Sbjct: 316 LACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531
N L ++ H PV + + S Y SG D W +
Sbjct: 376 ----NTVL-------YQGHAYPVWDLDISPYSLYFASGSHDRTARLW-----------SF 413
Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591
D + + GH V + F P S LA+ S D TVR+W + L T G
Sbjct: 414 DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT----GHRG 469
Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651
S+AF+ PN
Sbjct: 470 PVLSLAFS-----------------------------------------------PNGKY 482
Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
+A +D+ ++ D +G + H D +T L P+ + S S D S+R+W + N
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Query: 712 TC 713
C
Sbjct: 543 YC 544
Score = 33.1 bits (74), Expect = 0.97
Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 23/130 (17%)
Query: 400 GDLADLTVT----NDNDLSCDLSDSKDAFKKTW-----NPKFTLRSHYDGIRSLAFHHSQ 450
G LAD+ N N L+ + S D + W N H + SLAF +
Sbjct: 424 GHLADVDCVKFHPNSNYLA---TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480
Query: 451 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510
L +A ED LKLW+L K+ R H + ++ +S S
Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKE-----------LRGHTDNITSLTFSPDSGLIASAS 529
Query: 511 ADACIHSWKI 520
D + W I
Sbjct: 530 MDNSVRVWDI 539
Score = 32.3 bits (72), Expect = 1.7
Identities = 16/64 (25%), Positives = 29/64 (45%)
Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493
LR H D I SL F + +AS D ++++W+++ + E + +
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565
Query: 494 VLAV 497
VL+V
Sbjct: 566 VLSV 569
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 74.3 bits (181), Expect = 4e-13
Identities = 86/343 (25%), Positives = 132/343 (38%), Gaps = 32/343 (9%)
Query: 416 DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKK 475
D+ + K + + + KF +SH + R F L+T S DG +++WN T K
Sbjct: 195 DVEEEKFPTQLSRHIKFGQKSHVECAR---FSPDGQYLVTGSVDGFIEVWNF---TTGKI 248
Query: 476 NAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSV 535
L + F VL + ++E +G D I WKI
Sbjct: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS----------GQC 298
Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595
L H V L+FS S ++ S S D T+RI S T H +
Sbjct: 299 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVN 353
Query: 596 VAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQI--NQVVSHPNQPLT 652
A T T+ H + S S TV +++M+ T +S GS+ T I N V+ P P
Sbjct: 354 EA-TFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412
Query: 653 ITAHDDRGIRFLDNRTGKPVHSMVAHLDA---VTCLAVDPNGAFLMSGSHDCSLRLWSLD 709
+ + N G+ V S + C A+ P G ++ D L +S
Sbjct: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTV 472
Query: 710 NKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
+ +T H K + +A HP + LIA+ D L K++
Sbjct: 473 TGKLERTLTVHEKD----VIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 37.0 bits (84), Expect = 0.068
Identities = 35/179 (19%), Positives = 57/179 (31%), Gaps = 51/179 (28%)
Query: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKA----------------VTAKKNAA 478
R H + F +++AS DGT+K+WN++ +T
Sbjct: 346 RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVIL 405
Query: 479 LDVEPIHAFRAHR------------------------GPVLAVAMGSNSEYCYSGGADAC 514
L P H +R G + A+ E+ Y G D
Sbjct: 406 LPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFV 465
Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDP 573
++ + L L H V G+A P +A+ S DG +++W P
Sbjct: 466 LYCFSTVT-----------GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 73.9 bits (180), Expect = 5e-13
Identities = 81/335 (24%), Positives = 123/335 (36%), Gaps = 63/335 (18%)
Query: 422 DAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW----NLQKAVTAKKNA 477
DA KKT + + + +H ++L A +LW +L +A+ + A
Sbjct: 143 DALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVA------RLWIANYSLPRAMKRLEEA 196
Query: 478 ALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD-----------------ACIHS--- 517
L E R + L ++ S + +C G D AC
Sbjct: 197 RLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCK 256
Query: 518 -WKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ--------RLASCSADGTV 568
W +PD + L H L GH V + F P S LASC+ADG+V
Sbjct: 257 LWSVPDCN-----------LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305
Query: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSAL 626
++W S P A G VA P+ D L+D+E +
Sbjct: 306 KLWSLDSDEPV-------ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 627 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA 686
L E + + H + L T D R D RTG+ + + HL + +
Sbjct: 359 LHQEGHSMG----VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414
Query: 687 VDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
PNG + +GS D + ++W L + CV I AH+
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449
Score = 47.4 bits (111), Expect = 5e-05
Identities = 69/330 (20%), Positives = 116/330 (35%), Gaps = 80/330 (24%)
Query: 385 DVFIMDTIGGGEVSLGDLA---DLTVTNDNDLSCDLSDSKDAFKKTWN-----PKFTLRS 436
D ++ T+ G ++G + TV+ D S + D K W+ P +
Sbjct: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321
Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
H + + +H S L T D + +LW+L+ E I H V
Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-----------EEILHQEGHSMGVYD 370
Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556
+A + +GG DA W + + LEGH ++G+ FSP
Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF-----------LEGHLKEIYGINFSPNG 419
Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV 616
+A+ S D T ++WD C + + + T V F EP H
Sbjct: 420 YHIATGSGDNTCKVWDLRQRR----CVYTIPAHQNLVTGVKF---EPIH----------- 461
Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676
G+ LLT G+ T ++ +HP P+ ++
Sbjct: 462 ------GNFLLT----GAYDNTA--KIWTHPGW--------------------SPLKTLA 489
Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
H V L + +G + + S+D + +LW
Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 73.2 bits (178), Expect = 8e-13
Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 26/241 (10%)
Query: 512 DACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
D+C+ W + P ++ GH DAV + FSP+ LAS S D TVRIW
Sbjct: 2 DSCLMVWHMK-----------PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLE 630
P+ + + TA+ SV F S + + AS TV ++ L +L
Sbjct: 51 VPNVKGESTVFRAHTATVR----SVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSL- 103
Query: 631 SRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPN 690
S + P+ L ++A DD+ ++ D + + VHS H VT + P+
Sbjct: 104 ---SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160
Query: 691 GAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAK 750
G + + D ++++W + +Q H + H A++ ++ HPS + +A +D+ K
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216
Query: 751 V 751
+
Sbjct: 217 I 217
Score = 63.9 bits (154), Expect = 5e-10
Identities = 65/292 (22%), Positives = 108/292 (36%), Gaps = 40/292 (13%)
Query: 422 DAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKAVTAK 474
D+ W+ K + H D + + F S L + S D T+++W N++ T
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
FRAH V +V S+ + + D + W
Sbjct: 61 ------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT-----------HRQ 97
Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
L H + V FSP + + S S D TV++WD SS C G T
Sbjct: 98 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVT 153
Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 654
V F + I A+ ++D+ L + ++ +N + HP+ IT
Sbjct: 154 YVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGNYLIT 208
Query: 655 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
A D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 209 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 222 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 73.2 bits (178), Expect = 8e-13
Identities = 85/387 (21%), Positives = 142/387 (36%), Gaps = 86/387 (22%)
Query: 418 SDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
S S D + W+ P FT + H + S+++ L + ++G + LW+
Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190
Query: 473 AKKNAA--------LDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLS 524
+ A L EP+HA Y S D + W
Sbjct: 191 VGRTLAGHSKWITGLSWEPLHA-------------NPECRYVASSSKDGSVRIW------ 231
Query: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTF 584
D G +L GH +V L + L S S D T+++W + LC
Sbjct: 232 -DTTAGR----CERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW---RAHDGVLCR- 281
Query: 585 PTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSS--------G 636
T HG + ST+ A +F + + ++ +L L+ R S G
Sbjct: 282 -TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340
Query: 637 PTQ-------------------------------INQVVSHPNQPLTITAHDDRGIRFLD 665
P + INQV+ P+ + +A D+ I+ D
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725
RTGK + S+ H+ AV +A + L+SGS D +L++W + Q++ H
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----AQKLAMDLPGHA 456
Query: 726 EAIHAVACHPSKALIASAGADALAKVF 752
+ ++AV P +AS G D +++
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 72.4 bits (176), Expect = 1e-12
Identities = 53/183 (28%), Positives = 84/183 (45%), Gaps = 8/183 (4%)
Query: 540 LEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFT 599
LEGH +AV +AFSPT + LAS S D TVR WD S+ +P C H V S+++
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC---KGHRHWV-LSISW- 164
Query: 600 STEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD-- 657
S + + + ++G +L+D G + + S T ++ H N A
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
D +R D G+ + H +VTCL +G L S S D ++++W + + +
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283
Query: 718 TAH 720
H
Sbjct: 284 QGH 286
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 16/107 (14%)
Query: 418 SDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
S S D K W+ + +LR H + +A+ L++ S D TLK+W+++
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA--- 445
Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519
+ A+D+ H V AV + + SGG D C+ W+
Sbjct: 446 --QKLAMDLP------GHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 38.1 bits (87), Expect = 0.030
Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 14/106 (13%)
Query: 617 LYDMEVGSAL-LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSM 675
++D E+ S+L TLES+ + +V+ QP I F + S+
Sbjct: 64 VHDAEIVSSLGKTLESQA----VETEKVLDIIYQPQAI---------FRVRAVTRCTSSL 110
Query: 676 VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721
H +AV +A P G +L SGS D ++R W L +T HR
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 71.6 bits (174), Expect = 2e-12
Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 22/187 (11%)
Query: 450 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI-----HAFRAHRGPVLAVAMGSNSE 504
+S L+T S+D T+KLW L KA+ +K N A D PI R H + +VA+ N +
Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSK-NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDK 492
Query: 505 YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSA 564
+G D W +P L V GH +W + FSP Q LA+ SA
Sbjct: 493 LLATGSQDRTAKLWALPQCQ-----------LLGVFSGHRRGLWCVQFSPMDQVLATASA 541
Query: 565 DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGS 624
DGT+++W S CL TF VAF S +++S G L+ ++
Sbjct: 542 DGTIKLWALQDFS--CLKTF--EGHDASVLKVAFVS-RGTQLLSSGSDGLVKLWTIKNNE 596
Query: 625 ALLTLES 631
+ TL++
Sbjct: 597 CVRTLDA 603
Score = 61.6 bits (148), Expect = 3e-09
Identities = 74/335 (22%), Positives = 127/335 (37%), Gaps = 43/335 (12%)
Query: 454 LTASEDGTLKLWNL---QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510
LTA + GTL++W Q T + E H AH V+ A ++ Y
Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322
Query: 511 A-----DACIHSWKIPDLS-MDPYDGY------DPSV--------LSHVLEGHGDAVWGL 550
+ +S ++ D+ + P D + P + +L GH D V L
Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL 382
Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
ASC+ D +VRIW + + + H V T V + + + +V
Sbjct: 383 DVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT-VCCSRLKESFLVTG- 440
Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGP-------------TQINQVVSHPNQPLTITAHD 657
S D + + ALL+ + +GP IN V PN L T
Sbjct: 441 -SQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQ 499
Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717
DR + + + H + C+ P L + S D +++LW+L + +C++
Sbjct: 500 DRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559
Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
+ H+ ++ VA + S+G+D L K++
Sbjct: 560 ----EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 57.0 bits (136), Expect = 6e-08
Identities = 45/157 (28%), Positives = 60/157 (38%), Gaps = 27/157 (17%)
Query: 420 SKDAFKKTWN-PKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
S+D K W P+ L H G+ + F L TAS DGT+KLW LQ
Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ------ 551
Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
D + F H VL VA S S G+D + W I + +
Sbjct: 552 -----DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN-----------N 595
Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
L+ H D VWGL S + ++D V +W
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
T R H I S+A + L T S+D T KLW L + + + F HR
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQC-----------QLLGVFSGHRR 522
Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLS-MDPYDGYDPSVLSHVLEGHGDAVWGLA 551
+ V + + AD I W + D S + ++G+D SVL +A
Sbjct: 523 GLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLK------------VA 570
Query: 552 FSPTSQRLASCSADGTVRIW 571
F +L S +DG V++W
Sbjct: 571 FVSRGTQLLSSGSDGLVKLW 590
Score = 50.8 bits (120), Expect = 5e-06
Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 40/356 (11%)
Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
S + DA + W+ + L +HY + SLAF +L++ D +W+LQ +
Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-SCQ 228
Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYD 532
A + + A PV + + S Y + G + W+ Y
Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAAS-GQCVYTQAQ 287
Query: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592
P G G + + T+ + + +AD + +++ + S F SE +
Sbjct: 288 P-------PGPGQELTHCTLAHTAGVVLTATADHNLLLYE--ARSLRLQKQFAGYSEEVL 338
Query: 593 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP-L 651
V F E +H+V + S +++++ + + G T I + + L
Sbjct: 339 --DVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL------HGHTDIVLALDVFRKGWL 390
Query: 652 TITAHDDRGIR-FLDNRTGKP--VHSMVAHLDAV-TCLAVDPNGAFLMSGSHDCSLRLWS 707
+ D+ +R + N+ G+ V H +V T +FL++GS DC+++LW
Sbjct: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP 450
Query: 708 L-----------DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
L DN + + ++ H++ I++VA P+ L+A+ D AK++
Sbjct: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
Score = 44.7 bits (104), Expect = 3e-04
Identities = 78/365 (21%), Positives = 119/365 (32%), Gaps = 72/365 (19%)
Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
H + ++AF + + L T DG +++W++ + H FR G V
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGT-----------HHFRGSPGVVHL 156
Query: 497 VAMGSNSE--YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSP 554
VA + +S DA I W + D S VL H AV LAFS
Sbjct: 157 VAFHPDPTRLLLFSSATDAAIRVWSLQDRSC-----------LAVLTAHYSAVTSLAFSA 205
Query: 555 TSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV-----PTSVAFTSTEPAHIVAS 609
+ S D IWD S + E V P S + + + +
Sbjct: 206 DGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265
Query: 610 FRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSH-PNQPLTITA------HDDRGIR 662
G +++ G + T G + ++H LT TA ++ R +R
Sbjct: 266 GDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLR 325
Query: 663 F-----------LDNRTGKPVHSMV-----------------------AHLDAVTCLAVD 688
LD R P S V H D V L V
Sbjct: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVF 385
Query: 689 PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK-ALIASAGADA 747
G S + D S+R+W + NK A H ++ V C K + + + D
Sbjct: 386 RKGWLFASCAKDQSVRIWRM-NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444
Query: 748 LAKVF 752
K++
Sbjct: 445 TVKLW 449
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 71.2 bits (173), Expect = 3e-12
Identities = 117/579 (20%), Positives = 220/579 (37%), Gaps = 69/579 (11%)
Query: 184 EVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQ 243
++ Y I D + + G S + +E +GA P +I
Sbjct: 219 DIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPED----------RILSC 268
Query: 244 IKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDED-------DELDSVQHKKQRVKLPS 296
K + ++G++R+ + + + C DS + E+ KK + K
Sbjct: 269 RKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMK-KARK 327
Query: 297 KALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGI 356
KA + + E+E+ + ++ D + + + + + + SPH LQ
Sbjct: 328 KAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNN 387
Query: 357 LADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCD 416
L +L ++ P P P+P I TIGG D+ L+ ++DN
Sbjct: 388 LVELYSLN----------PSLPTPQPVRTSRI--TIGGHR---SDVRTLSFSSDN--IAV 430
Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSA--------LLTASEDGTLKLWNLQ 468
LS + D+ K WN RS IR++ ++ + ++ ++ G L+L++L
Sbjct: 431 LSAAADSIK-IWN-----RSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPY 528
+ AH G + ++++ + +GGAD + W + +
Sbjct: 485 SG-----------NLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENS 533
Query: 529 DGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTAS 588
SV + V +++SP + LA D TV+I+ + L F +
Sbjct: 534 TQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT-----LKFFLSLY 588
Query: 589 EHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPN 648
H +P S + A I + ++ ++ G +L + S + + P
Sbjct: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS----VMYLQFVPK 644
Query: 649 QPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708
L TA D I+ D + + ++ H + CLAV P+G +++S SHD SLRLW
Sbjct: 645 SHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWER 704
Query: 709 DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADA 747
+ + E ++ E +VA A+ D+
Sbjct: 705 TREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDS 743
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/134 (23%), Positives = 59/134 (44%), Gaps = 8/134 (5%)
Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676
++D+ G +L L+ ++ + P+ ++D IR +G+ +
Sbjct: 49 IWDLRKGEKILILQGLKQ----EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN 104
Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPS 736
H A+T L D G L SGS D + +W + N++ + + K H++AI
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL----KGHKDAITQALFLRE 160
Query: 737 KALIASAGADALAK 750
K L+ ++G D + K
Sbjct: 161 KNLLVTSGKDTMVK 174
Score = 38.9 bits (89), Expect = 0.018
Identities = 25/140 (17%), Positives = 50/140 (35%), Gaps = 22/140 (15%)
Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
T H I +L + L + S+D + +W++ ++ ++ + H+
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV-----------INESGLYRLKGHKD 150
Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
+ + G D + W + D + GH VWGL
Sbjct: 151 AITQALFLREKNLLVTSGKDTMVKWWDL-----------DTQHCFKTMVGHRTEVWGLVL 199
Query: 553 SPTSQRLASCSADGTVRIWD 572
+RL + ++D +R+WD
Sbjct: 200 LSEEKRLITGASDSELRVWD 219
Score = 36.6 bits (83), Expect = 0.088
Identities = 38/170 (22%), Positives = 68/170 (40%), Gaps = 9/170 (5%)
Query: 539 VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 598
+L+G V L SP LA DG++RI+ S T + H +
Sbjct: 60 ILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNV-----TFNGHKAAITTLK 114
Query: 599 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDD 658
+ + + D +++D+ S L L+ + I Q + + L +T+ D
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDA----ITQALFLREKNLLVTSGKD 170
Query: 659 RGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708
+++ D T +MV H V L + L++G+ D LR+W +
Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 34.7 bits (78), Expect = 0.34
Identities = 34/138 (24%), Positives = 56/138 (40%), Gaps = 24/138 (17%)
Query: 393 GGGEVSL-GDLADLTVTNDNDLSCDL-SDSKDAFKKTWNP-----KFTLRSHYDGIRSLA 445
G G V+ G A +T + L L S SKD W+ + L+ H D I
Sbjct: 97 GEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQAL 156
Query: 446 FHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFR---AHRGPVLAVAMGSN 502
F ++ L+T+ +D +K W D++ H F+ HR V + + S
Sbjct: 157 FLREKNLLVTSGKDTMVKWW--------------DLDTQHCFKTMVGHRTEVWGLVLLSE 202
Query: 503 SEYCYSGGADACIHSWKI 520
+ +G +D+ + W I
Sbjct: 203 EKRLITGASDSELRVWDI 220
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 71.2 bits (173), Expect = 3e-12
Identities = 70/273 (25%), Positives = 113/273 (41%), Gaps = 36/273 (13%)
Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496
H D + FH S L T+S D T+KLW+L K + I F H V +
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG-----------DCILTFEGHSRAVWS 441
Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556
S + S D W + + L GH D+V + F P S
Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDV-----------NSERCRCTLYGHTDSVNSIEFFPFS 490
Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIVASFRS-GD 614
L + SAD T+ IWD + +C S +G S+ +P H++AS + G
Sbjct: 491 NTLLTSSADKTLSIWDARTG----IC---EQSLYGHMHSINDAIFDPRGHMIASCDACGV 543
Query: 615 TVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 674
T L+D +++++ GP+ N+V + + A + I LD ++G+ +H
Sbjct: 544 TKLWDFRKLLPIVSID----IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHK 598
Query: 675 MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
++ H + + +G L SG D ++R WS
Sbjct: 599 LMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 55.8 bits (133), Expect = 1e-07
Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 38/250 (15%)
Query: 466 NLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSM 525
NL + + A D + + FR H PV V+M + + S G D WK+ L
Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRL---WKVLGLPK 383
Query: 526 DPYDGYDPSVLSHVLEGHGDAVW--GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCT 583
+ +L G G W F P+ +LA+ S D TV++WD C+ T
Sbjct: 384 ----------CNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILT 431
Query: 584 FPTASE-------HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG 636
F S H VA +S + + ++D+ TL S
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKT----------SKIWDVNSERCRCTLYGHTDS- 480
Query: 637 PTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 696
+N + P +T+ D+ + D RTG S+ H+ ++ DP G + S
Sbjct: 481 ---VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIAS 537
Query: 697 GSHDCSLRLW 706
+LW
Sbjct: 538 CDACGVTKLW 547
Score = 38.5 bits (88), Expect = 0.023
Identities = 50/191 (26%), Positives = 72/191 (37%), Gaps = 50/191 (26%)
Query: 418 SDSKDAFKKTWNP-----KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472
S S D K W+ + TL H D + S+ F + LLT+S D TL +W+ + +
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC--IHSWK----IPDLSMD 526
+ A RG ++A DAC W +P +S+D
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIA-------------SCDACGVTKLWDFRKLLPIVSID 559
Query: 527 --PYDG----YDPS--VLS------------------HVLEGHGDAVWGLAFSPTSQRLA 560
P G +D S VL+ H L GH + + FS + L
Sbjct: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILF 619
Query: 561 SCSADGTVRIW 571
S +DGTVR W
Sbjct: 620 SGGSDGTVRTW 630
Score = 36.2 bits (82), Expect = 0.12
Identities = 23/113 (20%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699
++ V P++ + ++ +DR + L + + H D ++ P+G L + S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
D +++LW L C+ H + A+ + H +AS+ D +K++
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSR----AVWSCTWHSCGNFVASSSLDKTSKIW 463
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 71.2 bits (173), Expect = 3e-12
Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 37/316 (11%)
Query: 435 RSHYDGIRSLAF----HHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490
++H D I S+A+ + ++T S D +K+W ++ LD++ + H
Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGH 63
Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550
+ V++V + S DA I W + + + + G DA W L
Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQ----------IKSIDAGPVDA-WTL 112
Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
AFSP SQ LA+ + G V I+ S + + S+A+ S + ++ +
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKE----YSLDTRGKFILSIAY-SPDGKYLASGA 167
Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670
G ++D+ G L TLE G + P I + P+ L +TA DD I+ D +
Sbjct: 168 IDGIINIFDIATGKLLHTLE--GHAMP--IRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223
Query: 671 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHA 730
++ H V +A P+ +S S D S+++W + +TCV H++ +
Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF----DHQDQVWG 279
Query: 731 VACHPSKALIASAGAD 746
V + + + I S G D
Sbjct: 280 VKYNGNGSKIVSVGDD 295
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/297 (20%), Positives = 124/297 (41%), Gaps = 38/297 (12%)
Query: 417 LSDSKDAFKKTW-------NPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQK 469
++ S D K W + +++L H G+ S+ H+ ++S D ++LW+L+
Sbjct: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
Query: 470 AVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYD 529
K+ ++D P+ A+ +A +S+Y +G H K+
Sbjct: 96 G---KQIKSIDAGPVDAW--------TLAFSPDSQYLATG-----THVGKVNIF------ 133
Query: 530 GYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589
G + + L+ G + +A+SP + LAS + DG + I+D ++ T
Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK-----LLHTLEG 188
Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649
H +P S + +V + G +YD++ + TL S + V P+
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHAS----WVLNVAFCPDD 244
Query: 650 PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
+++ D+ ++ D T VH+ H D V + + NG+ ++S D + ++
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
TL H IRSL F L+TAS+DG +K++++Q A A H
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA-----------GTLSGHAS 233
Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
VL VA + + S +D + W + H H D VWG+ +
Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDV-----------GTRTCVHTFFDHQDQVWGVKY 282
Query: 553 SPTSQRLASCSADGTVRIWD 572
+ ++ S D + I+D
Sbjct: 283 NGNGSKIVSVGDDQEIHIYD 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,107,496
Number of Sequences: 37866
Number of extensions: 2089725
Number of successful extensions: 29442
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 456
Number of HSP's successfully gapped in prelim test: 766
Number of HSP's that attempted gapping in prelim test: 16932
Number of HSP's gapped (non-prelim): 9565
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.