BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|89886477 zinedin isoform 1 [Homo sapiens] (753 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|89886477 zinedin isoform 1 [Homo sapiens] 1526 0.0 gi|89886480 zinedin isoform 2 [Homo sapiens] 1519 0.0 gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 751 0.0 gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 748 0.0 gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 707 0.0 gi|16554629 WD repeat domain 5 [Homo sapiens] 99 1e-20 gi|16554627 WD repeat domain 5 [Homo sapiens] 99 1e-20 gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 9e-20 gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19 gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19 gi|23199987 WD repeat domain 5B [Homo sapiens] 89 1e-17 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 87 7e-17 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 87 7e-17 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 86 1e-16 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 84 6e-16 gi|26665869 WD repeat domain 51B [Homo sapiens] 80 9e-15 gi|32189425 WD repeat domain 69 [Homo sapiens] 79 1e-14 gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 79 2e-14 gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 79 2e-14 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 2e-14 gi|21536371 telomerase-associated protein 1 [Homo sapiens] 78 3e-14 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 77 8e-14 gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 74 4e-13 gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 74 5e-13 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 73 8e-13 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 73 8e-13 gi|19913369 transducin beta-like 3 [Homo sapiens] 72 2e-12 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 71 3e-12 gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 71 3e-12 gi|13376840 WD repeat domain 61 [Homo sapiens] 71 3e-12 >gi|89886477 zinedin isoform 1 [Homo sapiens] Length = 753 Score = 1526 bits (3951), Expect = 0.0 Identities = 753/753 (100%), Positives = 753/753 (100%) Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60 Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120 Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180 Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300 Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360 Query: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDS 420 Query: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD Sbjct: 421 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480 Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL Sbjct: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540 Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS Sbjct: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTS 600 Query: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG Sbjct: 601 TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRG 660 Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH Sbjct: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAH 720 Query: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753 RKKHEEAIHAVACHPSKALIASAGADALAKVFV Sbjct: 721 RKKHEEAIHAVACHPSKALIASAGADALAKVFV 753 >gi|89886480 zinedin isoform 2 [Homo sapiens] Length = 760 Score = 1519 bits (3933), Expect = 0.0 Identities = 753/760 (99%), Positives = 753/760 (99%), Gaps = 7/760 (0%) Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60 Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120 Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180 Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300 Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360 Query: 361 RDVDGLPPKVTGPPPGTPQPRPHE-------DVFIMDTIGGGEVSLGDLADLTVTNDNDL 413 RDVDGLPPKVTGPPPGTPQPRPHE DVFIMDTIGGGEVSLGDLADLTVTNDNDL Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420 Query: 414 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 473 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA Sbjct: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480 Query: 474 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 533 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP Sbjct: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540 Query: 534 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 593 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP Sbjct: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600 Query: 594 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI Sbjct: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660 Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC Sbjct: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720 Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV Sbjct: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760 >gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] Length = 713 Score = 751 bits (1938), Expect = 0.0 Identities = 415/762 (54%), Positives = 511/762 (67%), Gaps = 80/762 (10%) Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62 L G G GP AAP GPG P G G GGG P GP AGPE Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62 Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122 ++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122 Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181 YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182 Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233 Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294 ++IKR++ G VL FL+N +D D DE++++ +H+ + K+ Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283 Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354 ++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+ Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330 Query: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLS 414 +T P G D ++ +G LGDLADLTVTND D S Sbjct: 331 -------------EPITFPSGGGKSFIMGSDDVLLSVLG-----LGDLADLTVTNDADYS 372 Query: 415 CDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474 DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V AK Sbjct: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432 Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534 K+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y+P+ Sbjct: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPN 492 Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594 VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG+PT Sbjct: 493 VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPT 551 Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPL 651 SV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP P+ Sbjct: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPV 611 Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711 TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+K Sbjct: 612 TITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSK 671 Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753 TCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV Sbjct: 672 TCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713 >gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] Length = 797 Score = 748 bits (1931), Expect = 0.0 Identities = 426/820 (51%), Positives = 529/820 (64%), Gaps = 112/820 (13%) Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62 L G G GP AAP GPG P G G GGG P GP AGPE Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62 Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122 ++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122 Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181 YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182 Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240 L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233 Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294 ++IKR++ G VL FL+N +D D DE++++ +H+ + K+ Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283 Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELE------- 347 ++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+ + + Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWDKDDLSPTAE 339 Query: 348 ----------------------------SRRVKLQGILADLRDVDGLPPKVTG----PPP 375 + R KL ++ADL D D LP +G Sbjct: 340 VWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGD-DELPHIPSGIINQSRS 398 Query: 376 GTPQPRPHEDVFIMDT------IGGGE-------------VSLGDLADLTVTNDNDLSCD 416 + + HE + GGG+ + LGDLADLTVTND D S D Sbjct: 399 ASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYD 458 Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKN 476 L +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V AKK+ Sbjct: 459 LPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 518 Query: 477 AALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVL 536 A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y+P+VL Sbjct: 519 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 578 Query: 537 SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSV 596 + L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG+PTSV Sbjct: 579 AGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPTSV 637 Query: 597 AFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPLTI 653 F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP P+TI Sbjct: 638 DFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTI 697 Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713 TAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+KTC Sbjct: 698 TAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTC 757 Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753 VQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV Sbjct: 758 VQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 797 >gi|51242945 striatin, calmodulin binding protein [Homo sapiens] Length = 780 Score = 707 bits (1826), Expect = 0.0 Identities = 394/795 (49%), Positives = 499/795 (62%), Gaps = 84/795 (10%) Query: 24 AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80 AGPG + P + A G GP + G G+ A SLPGILHF+QHEWARFE Sbjct: 5 AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64 Query: 81 AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140 E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+ Sbjct: 65 VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124 Query: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200 LNQG+ K + E +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR Sbjct: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184 Query: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260 +LLG S ++ + + +V E ++K A + S Sbjct: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229 Query: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320 VL FL++ + SDED++ D +K + + + D E+ D+++A+ EFD Sbjct: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289 Query: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349 FL + E+G+ + R DG+ E E + Sbjct: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346 Query: 350 ----RVKLQGILADLRDVDGLP---PKVTGPPPGTPQPRPHEDV---------------- 386 R KLQ +LA+LRDVD LP P V P + P ++ Sbjct: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406 Query: 387 --FIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 441 FIM D E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI Sbjct: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466 Query: 442 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 501 R+LAFH + L+TASED TLK+WNLQK AKK+ +LDVEPI+ FRAH+GPVL V M S Sbjct: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526 Query: 502 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 561 N E CYSGG D I W + ++DPYD YDPSVL L GH DAVWGLA+S QRL S Sbjct: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586 Query: 562 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 621 CSADGT+R+W+ + +PA L F E G+P SV S++P+H+VASF G T +++ME Sbjct: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645 Query: 622 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 678 +LTLES ++ QIN+V+SHP P++ITAH+DR I+F DN TGK +HSMVAH Sbjct: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705 Query: 679 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 738 L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK Sbjct: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765 Query: 739 LIASAGADALAKVFV 753 IASAGADALAKVFV Sbjct: 766 YIASAGADALAKVFV 780 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 99.4 bits (246), Expect = 1e-20 Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%) Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484 K + KFTL H + S+ F + L ++S D +K+W A D + Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80 Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544 H+ + VA S+S S D + W + L+GH Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129 Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604 + V+ F+P S + S S D +VRIWD + CL T P H P S + + + Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184 Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664 IV+S G ++D G L TL + ++ V PN + A D ++ Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241 Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721 D GK + + H + C+ + G +++SGS D + +W+L K VQ++ Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297 Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746 + H + + + ACHP++ +IASA + Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322 Score = 56.6 bits (135), Expect = 8e-08 Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%) Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699 I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 D S+R+W + C++ + A H + + AV + +LI S+ D L +++ Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 99.4 bits (246), Expect = 1e-20 Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%) Query: 425 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 484 K + KFTL H + S+ F + L ++S D +K+W A D + Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80 Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544 H+ + VA S+S S D + W + L+GH Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129 Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604 + V+ F+P S + S S D +VRIWD + CL T P H P S + + + Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184 Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664 IV+S G ++D G L TL + ++ V PN + A D ++ Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241 Query: 665 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721 D GK + + H + C+ + G +++SGS D + +W+L K VQ++ Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297 Query: 722 KKHEEAIHAVACHPSKALIASAGAD 746 + H + + + ACHP++ +IASA + Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322 Score = 56.6 bits (135), Expect = 8e-08 Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%) Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699 I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 D S+R+W + C++ + A H + + AV + +LI S+ D L +++ Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 >gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 96.3 bits (238), Expect = 9e-20 Identities = 49/82 (59%), Positives = 59/82 (71%), Gaps = 9/82 (10%) Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133 K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66 Query: 134 KLKFGTDLNQGEKKADVSEQVS 155 KLK+G +LNQG+ K + + S Sbjct: 67 KLKYGRELNQGDMKPPIYDSDS 88 >gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 95.5 bits (236), Expect = 2e-19 Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%) Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133 K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66 Query: 134 KLKFGTDLNQGEKK 147 KLK+G +LNQG+ K Sbjct: 67 KLKYGRELNQGDMK 80 >gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 95.5 bits (236), Expect = 2e-19 Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%) Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133 K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH Sbjct: 7 KSRWETGEVQAQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66 Query: 134 KLKFGTDLNQGEKK 147 KLK+G +LNQG+ K Sbjct: 67 KLKYGRELNQGDMK 80 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 89.0 bits (219), Expect = 1e-17 Identities = 79/319 (24%), Positives = 131/319 (41%), Gaps = 37/319 (11%) Query: 431 KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490 K TL H + + S+ F + L ++S D + +W A D + H Sbjct: 34 KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG-----------AYDGKYEKTLYGH 82 Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550 + VA S+S S D + W + L+GH + V+ Sbjct: 83 NLEISDVAWSSDSSRLVSASDDKTLKLWDVRS-----------GKCLKTLKGHSNYVFCC 131 Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610 F+P S + S S D TV+IW+ + CL T S H P S + + IV+ Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGK--CL---KTLSAHSDPVSAVHFNCSGSLIVSGS 186 Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670 G ++D G L TL + ++ V PN +TA D ++ D G+ Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNP---PVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243 Query: 671 PVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEA 727 + + H + C+ + G +++SGS D + +W+L K VQ++ H + Sbjct: 244 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT----DV 299 Query: 728 IHAVACHPSKALIASAGAD 746 + + ACHP++ LIASA + Sbjct: 300 VISAACHPTENLIASAALE 318 Score = 67.0 bits (162), Expect = 6e-11 Identities = 47/182 (25%), Positives = 85/182 (46%), Gaps = 9/182 (4%) Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595 L L GH +AV + FSP + LAS SAD + IW T H + S Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-----KTLYGHNLEIS 87 Query: 596 VAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA 655 S++ + +V++ L+D+ G L TL+ + + +P L I+ Sbjct: 88 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN----YVFCCNFNPPSNLIISG 143 Query: 656 HDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQ 715 D ++ + +TGK + ++ AH D V+ + + +G+ ++SGS+D R+W + C++ Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203 Query: 716 EI 717 + Sbjct: 204 TL 205 Score = 56.2 bits (134), Expect = 1e-07 Identities = 29/114 (25%), Positives = 61/114 (53%), Gaps = 4/114 (3%) Query: 639 QINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGS 698 +I+ V + ++A DD+ ++ D R+GK + ++ H + V C +P ++SGS Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144 Query: 699 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 D ++++W + C++ ++A H + + AV + S +LI S D L +++ Sbjct: 145 FDETVKIWEVKTGKCLKTLSA----HSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 86.7 bits (213), Expect = 7e-17 Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%) Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546 F+ HR V V N++ SG D+C+ W + P ++ GH DA Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63 Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606 V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + + Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119 Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665 AS TV ++ L +L S + P+ L ++A DD+ ++ D Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173 Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725 + + VHS H VT + P+G + + D ++++W + +Q H + H Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229 Query: 726 EAIHAVACHPSKALIASAGADALAKV 751 A++ ++ HPS + +A +D+ K+ Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255 Score = 66.2 bits (160), Expect = 1e-10 Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%) Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470 S S D+ W+ K + H D + + F S L + S D T+++W N++ Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95 Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530 T FRAH V +V S+ + + D + W Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132 Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590 L H + V FSP + + S S D TV++WD SS C Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187 Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650 G T V F + I A+ ++D+ L + ++ +N + HP+ Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242 Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 ITA D ++ LD G+ ++++ H T +A G + SG D + +W Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 52.4 bits (124), Expect = 2e-06 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%) Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468 +C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259 Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519 + ++ H+GP VA EY SGG+D + WK Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 86.7 bits (213), Expect = 7e-17 Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%) Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546 F+ HR V V N++ SG D+C+ W + P ++ GH DA Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63 Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606 V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + + Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119 Query: 607 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 665 AS TV ++ L +L S + P+ L ++A DD+ ++ D Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173 Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725 + + VHS H VT + P+G + + D ++++W + +Q H + H Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229 Query: 726 EAIHAVACHPSKALIASAGADALAKV 751 A++ ++ HPS + +A +D+ K+ Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255 Score = 66.2 bits (160), Expect = 1e-10 Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%) Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 470 S S D+ W+ K + H D + + F S L + S D T+++W N++ Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95 Query: 471 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 530 T FRAH V +V S+ + + D + W Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132 Query: 531 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 590 L H + V FSP + + S S D TV++WD SS C Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187 Query: 591 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 650 G T V F + I A+ ++D+ L + ++ +N + HP+ Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242 Query: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 ITA D ++ LD G+ ++++ H T +A G + SG D + +W Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 52.4 bits (124), Expect = 2e-06 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%) Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468 +C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259 Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519 + ++ H+GP VA EY SGG+D + WK Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 86.3 bits (212), Expect = 1e-16 Identities = 80/341 (23%), Positives = 139/341 (40%), Gaps = 62/341 (18%) Query: 417 LSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471 +S S+DA K W+ + TL+ H D ++ ++F HS L + S D T+KLW+ Q Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--- 180 Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531 E I H V +VA+ N ++ S D I W++ GY Sbjct: 181 --------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV-------QTGY 225 Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591 + GH + V + + +ASCS D TVR+W ++ C Sbjct: 226 CVKTFT----GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE----CKAELREHEH 277 Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651 V +++ + E ++ S +G E++ S P P Sbjct: 278 VVECISW-APESSYSSISEATGS---------------ETKKSGKP-----------GPF 310 Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711 ++ D+ I+ D TG + ++V H + V + G F++S + D +LR+W NK Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370 Query: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 C++ + A HE + ++ H + + + D KV+ Sbjct: 371 RCMKTLNA----HEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 74.7 bits (182), Expect = 3e-13 Identities = 70/292 (23%), Positives = 117/292 (40%), Gaps = 52/292 (17%) Query: 485 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 544 +A HR PV V S DA I W Y+ L+GH Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-----------YETGDFERTLKGHT 150 Query: 545 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP- 603 D+V ++F + + LASCSAD T+++WD C+ T HG +V+ + P Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFE--CIRTM-----HGHDHNVSSVAIMPN 203 Query: 604 -AHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA--HDDRG 660 HIV++ R +++++ G + T +G + ++V PNQ T+ A +D+ Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTF-----TGHREWVRMV-RPNQDGTLIASCSNDQT 257 Query: 661 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPN--------------------GAFLMSGSHD 700 +R T + + H V C++ P G FL+SGS D Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317 Query: 701 CSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 ++++W + C+ + H+ + V H I S D +V+ Sbjct: 318 KTIKMWDVSTGMCLMTLVG----HDNWVRGVLFHSGGKFILSCADDKTLRVW 365 Score = 31.6 bits (70), Expect = 2.8 Identities = 26/120 (21%), Positives = 42/120 (35%), Gaps = 22/120 (18%) Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512 LL+ S D T+K+W++ + + H V V S ++ S D Sbjct: 311 LLSGSRDKTIKMWDVSTGMC-----------LMTLVGHDNWVRGVLFHSGGKFILSCADD 359 Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572 + W Y L H V L F T+ + + S D TV++W+ Sbjct: 360 KTLRVWD-----------YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 83.6 bits (205), Expect = 6e-16 Identities = 90/339 (26%), Positives = 138/339 (40%), Gaps = 47/339 (13%) Query: 425 KKTWNPKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 480 K W+P + L H +R +A +T S D T+K+W+L + K +L Sbjct: 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL- 242 Query: 481 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 540 H V V + + S Y +S G D + W DL + V+ H Sbjct: 243 -------TGHISTVRGVIVSTRSPYLFSCGEDKQVKCW---DLEYN-------KVIRH-Y 284 Query: 541 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH-GVPTSVAFT 599 GH AV+GL PT L +CS D T RIWD + + + T S H +V Sbjct: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA-----SVHTLSGHTNAVATVRCQ 339 Query: 600 STEPAHIVASFRSGDTV--LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD 657 + EP I S DT L+D+ G +TL + S + VV HP T + Sbjct: 340 AAEPQIITGSH---DTTIRLWDLVAGKTRVTLTNHKKS----VRAVVLHPRH-YTFASGS 391 Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717 I+ G + ++ H + L V+ +G L+SG+ + ++ LW Q + Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRV 450 Query: 718 TAHRK----KHEEAIHAVACHPSKALIASAGADALAKVF 752 A + E I A A S++ + +A AD KV+ Sbjct: 451 HAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 79.7 bits (195), Expect = 9e-15 Identities = 74/293 (25%), Positives = 117/293 (39%), Gaps = 38/293 (12%) Query: 420 SKDAFKKTWNPKFTLRS-----HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474 S D F WN K R+ H D + S+ F + L +AS D T++LW K Sbjct: 37 SWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFS 96 Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534 + F+AH PV +V ++ ++ + D I W + Y Sbjct: 97 E-----------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQR 135 Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594 L + L H V FSP + + SCS D T++IWD ++ C + G Sbjct: 136 FL-YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFAN 190 Query: 595 SVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653 V F + +AS S TV ++D+ V L + +N + HP+ I Sbjct: 191 FVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGG----VNCISFHPSGNYLI 244 Query: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 TA D ++ LD G+ ++++ H V ++ G SG D + LW Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297 Score = 64.3 bits (155), Expect = 4e-10 Identities = 50/265 (18%), Positives = 101/265 (38%), Gaps = 24/265 (9%) Query: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 546 F+ H+ + ++ + N + + D + W + P ++ GH D Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62 Query: 547 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 606 V + FSP LAS S D TVR+W P F H P S + + Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRG-----KFSEFKAHTAPVRSVDFSADGQFL 117 Query: 607 VASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDN 666 + ++ M L +L + P+ L ++ +D+ I+ D Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRH----THWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173 Query: 667 RTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEE 726 + V++ + + +P+G + S D ++++W + V ++ H + H Sbjct: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSG 229 Query: 727 AIHAVACHPSKALIASAGADALAKV 751 ++ ++ HPS + +A +D K+ Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 16/111 (14%) Query: 414 SCDLSDSKDAFKKTWNPKFT-LRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468 +C S D K W+ + L HY G+ ++FH S + L+TAS DGTLK+ +L Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL- 257 Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519 L+ I+ + H GPV V+ E SGGAD + W+ Sbjct: 258 ----------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298 Score = 35.8 bits (81), Expect = 0.15 Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 4/76 (5%) Query: 678 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 737 H A+T L + PNG L + S D L LW+ H+ + + +V P Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72 Query: 738 ALIASAGADALAKVFV 753 L+ASA D ++++ Sbjct: 73 NLLASASRDRTVRLWI 88 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 79.3 bits (194), Expect = 1e-14 Identities = 78/303 (25%), Positives = 134/303 (44%), Gaps = 29/303 (9%) Query: 453 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 512 LLTAS +KL + +N+ +AH P+ VA+ + +G D Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113 Query: 513 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFS-PTSQRLASCSADGTVRIW 571 W D G + + LEGH + V+ +AF+ P ++A+ S D T ++W Sbjct: 114 RTCKLW-------DTASGEE----LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162 Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSALLTL 629 S + C TF G + S P + + S DT L+D++ G + TL Sbjct: 163 --SVETGKCYHTF-----RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215 Query: 630 ESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDP 689 RG S +I + + + IT D + D TG+ V+ ++ H ++ + + Sbjct: 216 --RGHSA--EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW 271 Query: 690 NGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALA 749 + + +++GS D + +LW N CV +T H +E + + + K LIA+A AD A Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGH---DDEILDSCFDYTGK-LIATASADGTA 327 Query: 750 KVF 752 ++F Sbjct: 328 RIF 330 Score = 74.7 bits (182), Expect = 3e-13 Identities = 68/313 (21%), Positives = 118/313 (37%), Gaps = 37/313 (11%) Query: 414 SCDLSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQS-ALLTASEDGTLKLWNL 467 SC ++ S D K W+ TL H + + ++AF++ + T S D T KLW++ Sbjct: 105 SCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV 164 Query: 468 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 527 + + H FR H ++ ++ S +G D W I + Sbjct: 165 ETG-----------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208 Query: 528 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 587 + L GH + L+F+ + R+ + S D TV +WD + + Sbjct: 209 ------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI---- 258 Query: 588 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHP 647 H S A + + + I+ L+D G + TL +I Sbjct: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD----EILDSCFDY 313 Query: 648 NQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707 L TA D R T K + + H ++ ++ +P G L++GS D + R+W Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 Query: 708 LDNKTCVQEITAH 720 C+Q + H Sbjct: 374 AQTGQCLQVLEGH 386 Score = 72.8 bits (177), Expect = 1e-12 Identities = 66/320 (20%), Positives = 129/320 (40%), Gaps = 36/320 (11%) Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493 L++H + ++A + S S +T S D T KLW+ E ++ HR Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG-----------EELNTLEGHRNV 136 Query: 494 VLAVAMGS-NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552 V A+A + + +G D W + + H GH + L+F Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSV-----------ETGKCYHTFRGHTAEIVCLSF 185 Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612 +P S +A+ S D T ++WD + + S++F ++ I SF Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEE----VYTLRGHSAEIISLSFNTSGDRIITGSF-D 240 Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672 V++D + G + L + +I+ + + L +T D+ + D GK V Sbjct: 241 HTVVVWDADTGRKVNILIGHCA----EISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296 Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVA 732 ++ H D + D G + + S D + R++S + C+ ++ + HE I ++ Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL----EGHEGEISKIS 352 Query: 733 CHPSKALIASAGADALAKVF 752 +P + + +D A+++ Sbjct: 353 FNPQGNHLLTGSSDKTARIW 372 Score = 70.1 bits (170), Expect = 7e-12 Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 31/274 (11%) Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492 T R H I L+F+ + + T S D T KLW++Q E ++ R H Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220 Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552 +++++ ++ + +G D + W D ++L GH + +F Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269 Query: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612 + + + S D T ++WD ++ C+ T + + + +T I + Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKL---IATASAD 324 Query: 613 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 672 G ++ + LE G G +I+++ +P +T D+ R D +TG+ + Sbjct: 325 GTARIFSAATRKCIAKLE--GHEG--EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 673 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 + H D + A + G +++GS D + R+W Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 >gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo sapiens] Length = 1233 Score = 79.0 bits (193), Expect = 2e-14 Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%) Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500 ++ L+FH + +LT+ +G ++LW+ + K F H GPV + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60 Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538 SGG D I W D + ++ P +LS Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120 Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589 VL GH V F PT + S S D TVR+WD S L S+ Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180 Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649 T V T A V +L RG +N HP Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217 Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707 PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277 Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 + +T VQ R+ H+ +A HP+ L A AG D VF Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317 Score = 67.4 bits (163), Expect = 5e-11 Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%) Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471 +S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126 Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527 + H V+ + S D + W I L ++ P Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175 Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574 G +V+ HVLEGH V AF PT + S + D V+IW + Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634 S T H S A I+++ ++DM + + T Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288 Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678 + + +HPN L HD I F R VH + H Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334 >gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo sapiens] Length = 1224 Score = 79.0 bits (193), Expect = 2e-14 Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%) Query: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500 ++ L+FH + +LT+ +G ++LW+ + K F H GPV + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60 Query: 501 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 538 SGG D I W D + ++ P +LS Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120 Query: 539 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589 VL GH V F PT + S S D TVR+WD S L S+ Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180 Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649 T V T A V +L RG +N HP Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217 Query: 650 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707 PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277 Query: 708 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 + +T VQ R+ H+ +A HP+ L A AG D VF Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317 Score = 67.4 bits (163), Expect = 5e-11 Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%) Query: 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471 +S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126 Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 527 + H V+ + S D + W I L ++ P Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175 Query: 528 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 574 G +V+ HVLEGH V AF PT + S + D V+IW + Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 575 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 634 S T H S A I+++ ++DM + + T Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288 Query: 635 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 678 + + +HPN L HD I F R VH + H Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 78.6 bits (192), Expect = 2e-14 Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 28/207 (13%) Query: 455 TASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC 514 T S+DGT+KLW+++K I F+ + VLAV S+ SGG D Sbjct: 169 TGSDDGTVKLWDIRKKAA-----------IQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216 Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-- 572 I W + + L++ + GH D+V GL+ S L S + D TVR+WD Sbjct: 217 IKVWDLRQ-----------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265 Query: 573 PSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESR 632 P + C+ F + H ++ S P + S D +Y + S + + Sbjct: 266 PFAPKERCVKIFQ-GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324 Query: 633 GSSGPTQINQVVSHPNQPLTITAHDDR 659 G +G IN+V HP++P+ I+A D+ Sbjct: 325 GHAG--SINEVAFHPDEPIIISASSDK 349 Score = 68.9 bits (167), Expect = 2e-11 Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 25/275 (9%) Query: 483 PIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEG 542 PI H G V N S G D I W + D Y L+G Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----YGDCDNYA------TLKG 107 Query: 543 HGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTE 602 H AV L ++ L S S D TV +WD + H + + + Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERV-----KRLKGHTSFVNSCYPARR 162 Query: 603 PAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGI 661 +V + TV L+D+ +A+ T ++ Q+ V + I+ D I Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-----YQVLAVTFNDTSDQIISGGIDNDI 217 Query: 662 RFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL----DNKTCVQEI 717 + D R K ++M H D+VT L++ G++L+S + D ++R+W + + CV+ Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277 Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 + E+ + + P + IA+ AD V+ Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312 Score = 49.7 bits (117), Expect = 1e-05 Identities = 70/333 (21%), Positives = 123/333 (36%), Gaps = 58/333 (17%) Query: 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 489 P L H + FH + S L +A D + LWN+ D + + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG----------DCDNYATLKG 107 Query: 490 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHV--LEGHGDAV 547 H G V+ + ++ +S D + W D V L+GH V Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVW-------------DSETGERVKRLKGHTSFV 154 Query: 548 ---WGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 604 + P Q + + S DGTV++WD A + TF + +V F T Sbjct: 155 NSCYPARRGP--QLVCTGSDDGTVKLWD--IRKKAAIQTFQNTYQ---VLAVTFNDTSD- 206 Query: 605 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 664 I++ D ++D+ T+ S + + ++ D +R Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVW 262 Query: 665 DNRTGKP-----------VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713 D R P VH+ +L + C + P+G+ + +GS D + +W ++ Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNL--LRC-SWSPDGSKIAAGSADRFVYVWDTTSRRI 319 Query: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746 + ++ H +I+ VA HP + +I SA +D Sbjct: 320 LYKLPG----HAGSINEVAFHPDEPIIISASSD 348 Score = 43.1 bits (100), Expect = 0.001 Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 25/172 (14%) Query: 397 VSLGDLADLTVTN--DNDLSC-DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSAL 453 V+ D +D ++ DND+ DL +K + T+R H D + L+ S L Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTY--------TMRGHADSVTGLSLSSEGSYL 250 Query: 454 LTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADA 513 L+ + D T+++W+++ ++ + +H F + +L + + +G AD Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGSADR 307 Query: 514 CIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSAD 565 ++ W D +L + L GH ++ +AF P + S S+D Sbjct: 308 FVYVW----------DTTSRRIL-YKLPGHAGSINEVAFHPDEPIIISASSD 348 >gi|21536371 telomerase-associated protein 1 [Homo sapiens] Length = 2627 Score = 78.2 bits (191), Expect = 3e-14 Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%) Query: 449 SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 508 SQ L +ASED T++LW Q + + + A D R H GPV + ++ + Sbjct: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078 Query: 509 GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 568 GG D + W D P ++ H D V G A++ + L SCS+DG+V Sbjct: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130 Query: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 628 +WDP S G ++V+ + H+V+ R G ++D + G L + Sbjct: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182 Query: 629 LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 681 + + SGP P QP L +T D R H+++ H Sbjct: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240 Query: 682 VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 738 V AV +++ S D S+RLW + + TC+ +A A+ AVA P + Sbjct: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293 Query: 739 LIAS 742 + S Sbjct: 2294 MAVS 2297 Score = 48.9 bits (115), Expect = 2e-05 Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%) Query: 408 TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 462 T DN L +S S D W+P+ R H + ++A + +++ S DGTL Sbjct: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170 Query: 463 KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 522 K+W+ Q + + AH GP+ A G++ + + + Sbjct: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218 Query: 523 LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 579 + + P ++ +H L GH V A S TS + + S DG+VR+W P + Sbjct: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274 Query: 580 CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 639 C+ P +S T+VA+ + + + V+ ++G+ +L+ + A+ T ++ G G Sbjct: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325 Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 691 + S + ++A + + R G ++ HL+ + T L P+G Sbjct: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382 Query: 692 AFLMSGSHDCSL 703 FL+ D L Sbjct: 2383 HFLILAKADLKL 2394 Score = 46.2 bits (108), Expect = 1e-04 Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%) Query: 436 SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 486 +H+ + + F H+ LLTA EDG +++W+ +L + P + Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941 Query: 487 ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 524 +RA +G L VA+ + + + SG D + W + + S Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001 Query: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 583 + +L V GLA S + LAS S D TV++W + P Sbjct: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050 Query: 584 FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 640 FP +E H P S ST+ + R + +D+ + + S + + Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110 Query: 641 NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 700 + L I+ D + D +G+ + + H AV+ +A ++S S D Sbjct: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167 Query: 701 CSLRLW 706 +L++W Sbjct: 2168 GTLKVW 2173 Score = 33.9 bits (76), Expect = 0.57 Identities = 79/348 (22%), Positives = 130/348 (37%), Gaps = 49/348 (14%) Query: 426 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIH 485 +TW + ++ S DGI + F + LTA DG L+LW+LQ + A + Sbjct: 1706 RTWQEEKSVVSGCDGISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITG 1764 Query: 486 AFRAHRGPVLA-VAMGS----------------------NSEYCYSGGADACIHSWKIPD 522 + +LA V +G N + G SW Sbjct: 1765 CCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSW-AGS 1823 Query: 523 LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLC 582 +S DG ++ L G ++ LAF+ +A D V +W + A L Sbjct: 1824 ISFFQVDGLK---VTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW--AWREGARLA 1878 Query: 583 TFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 642 FP + HG + F ++ + G ++ +G RG G ++ Sbjct: 1879 AFP--AHHGFVAAALFLHA-GCQLLTAGEDGKVQVWSGSLG------RPRGHLGSLSLSP 1929 Query: 643 VVS---HPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA-VDPNGAFLMSGS 698 +S P+ + GIR +G A AV+ LA + P L+SG+ Sbjct: 1930 ALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGA 1987 Query: 699 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746 D SL+ W+L K C + + ++ + +A S+ L+ASA D Sbjct: 1988 EDGSLQGWAL--KECSLQSLWLLSRFQKPVLGLA--TSQELLASASED 2031 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 76.6 bits (187), Expect = 8e-14 Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 88/324 (27%) Query: 451 SALLTASEDGT-LKLWNLQKAVTAKKNAALDVEPIHA---------------------FR 488 S LL A D + +KLW+L+ + +DV IH R Sbjct: 280 SKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILR 339 Query: 489 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 548 H GPV + ++S S D I W + + +VL +GH VW Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--------GSFTNTVL---YQGHAYPVW 388 Query: 549 GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVA 608 L SP S AS S D T R+W +F T P I A Sbjct: 389 DLDISPYSLYFASGSHDRTARLW-------------------------SFDRTYPLRIYA 423 Query: 609 SFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRT 668 + ++ V HPN T D+ +R + Sbjct: 424 GHLA--------------------------DVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457 Query: 669 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAI 728 G V H V LA PNG +L S D L+LW L + T +E+ + H + I Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL----RGHTDNI 513 Query: 729 HAVACHPSKALIASAGADALAKVF 752 ++ P LIASA D +V+ Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVW 537 Score = 64.7 bits (156), Expect = 3e-10 Identities = 68/302 (22%), Positives = 105/302 (34%), Gaps = 74/302 (24%) Query: 413 LSCDLSDSKDAFKKTWNPKFT-LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 471 L+CD+ + +D + LR H + S F S LL+ SED +++ W+L Sbjct: 316 LACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375 Query: 472 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 531 N L ++ H PV + + S Y SG D W + Sbjct: 376 ----NTVL-------YQGHAYPVWDLDISPYSLYFASGSHDRTARLW-----------SF 413 Query: 532 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 591 D + + GH V + F P S LA+ S D TVR+W + L T G Sbjct: 414 DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT----GHRG 469 Query: 592 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 651 S+AF+ PN Sbjct: 470 PVLSLAFS-----------------------------------------------PNGKY 482 Query: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711 +A +D+ ++ D +G + H D +T L P+ + S S D S+R+W + N Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542 Query: 712 TC 713 C Sbjct: 543 YC 544 Score = 33.1 bits (74), Expect = 0.97 Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 23/130 (17%) Query: 400 GDLADLTVT----NDNDLSCDLSDSKDAFKKTW-----NPKFTLRSHYDGIRSLAFHHSQ 450 G LAD+ N N L+ + S D + W N H + SLAF + Sbjct: 424 GHLADVDCVKFHPNSNYLA---TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480 Query: 451 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510 L +A ED LKLW+L K+ R H + ++ +S S Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKE-----------LRGHTDNITSLTFSPDSGLIASAS 529 Query: 511 ADACIHSWKI 520 D + W I Sbjct: 530 MDNSVRVWDI 539 Score = 32.3 bits (72), Expect = 1.7 Identities = 16/64 (25%), Positives = 29/64 (45%) Query: 434 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 493 LR H D I SL F + +AS D ++++W+++ + E + + Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565 Query: 494 VLAV 497 VL+V Sbjct: 566 VLSV 569 >gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo sapiens] Length = 513 Score = 74.3 bits (181), Expect = 4e-13 Identities = 86/343 (25%), Positives = 132/343 (38%), Gaps = 32/343 (9%) Query: 416 DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKK 475 D+ + K + + + KF +SH + R F L+T S DG +++WN T K Sbjct: 195 DVEEEKFPTQLSRHIKFGQKSHVECAR---FSPDGQYLVTGSVDGFIEVWNF---TTGKI 248 Query: 476 NAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSV 535 L + F VL + ++E +G D I WKI Sbjct: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS----------GQC 298 Query: 536 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 595 L H V L+FS S ++ S S D T+RI S T H + Sbjct: 299 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVN 353 Query: 596 VAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQI--NQVVSHPNQPLT 652 A T T+ H + S S TV +++M+ T +S GS+ T I N V+ P P Sbjct: 354 EA-TFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412 Query: 653 ITAHDDRGIRFLDNRTGKPVHSMVAHLDA---VTCLAVDPNGAFLMSGSHDCSLRLWSLD 709 + + N G+ V S + C A+ P G ++ D L +S Sbjct: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTV 472 Query: 710 NKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 + +T H K + +A HP + LIA+ D L K++ Sbjct: 473 TGKLERTLTVHEKD----VIGIAHHPHQNLIATYSEDGLLKLW 511 Score = 37.0 bits (84), Expect = 0.068 Identities = 35/179 (19%), Positives = 57/179 (31%), Gaps = 51/179 (28%) Query: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKA----------------VTAKKNAA 478 R H + F +++AS DGT+K+WN++ +T Sbjct: 346 RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVIL 405 Query: 479 LDVEPIHAFRAHR------------------------GPVLAVAMGSNSEYCYSGGADAC 514 L P H +R G + A+ E+ Y G D Sbjct: 406 LPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFV 465 Query: 515 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDP 573 ++ + L L H V G+A P +A+ S DG +++W P Sbjct: 466 LYCFSTVT-----------GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513 >gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapiens] Length = 522 Score = 73.9 bits (180), Expect = 5e-13 Identities = 81/335 (24%), Positives = 123/335 (36%), Gaps = 63/335 (18%) Query: 422 DAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW----NLQKAVTAKKNA 477 DA KKT + + + +H ++L A +LW +L +A+ + A Sbjct: 143 DALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVA------RLWIANYSLPRAMKRLEEA 196 Query: 478 ALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD-----------------ACIHS--- 517 L E R + L ++ S + +C G D AC Sbjct: 197 RLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCK 256 Query: 518 -WKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ--------RLASCSADGTV 568 W +PD + L H L GH V + F P S LASC+ADG+V Sbjct: 257 LWSVPDCN-----------LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305 Query: 569 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSAL 626 ++W S P A G VA P+ D L+D+E + Sbjct: 306 KLWSLDSDEPV-------ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358 Query: 627 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA 686 L E + + H + L T D R D RTG+ + + HL + + Sbjct: 359 LHQEGHSMG----VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414 Query: 687 VDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721 PNG + +GS D + ++W L + CV I AH+ Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449 Score = 47.4 bits (111), Expect = 5e-05 Identities = 69/330 (20%), Positives = 116/330 (35%), Gaps = 80/330 (24%) Query: 385 DVFIMDTIGGGEVSLGDLA---DLTVTNDNDLSCDLSDSKDAFKKTWN-----PKFTLRS 436 D ++ T+ G ++G + TV+ D S + D K W+ P + Sbjct: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321 Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496 H + + +H S L T D + +LW+L+ E I H V Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-----------EEILHQEGHSMGVYD 370 Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556 +A + +GG DA W + + LEGH ++G+ FSP Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF-----------LEGHLKEIYGINFSPNG 419 Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV 616 +A+ S D T ++WD C + + + T V F EP H Sbjct: 420 YHIATGSGDNTCKVWDLRQRR----CVYTIPAHQNLVTGVKF---EPIH----------- 461 Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676 G+ LLT G+ T ++ +HP P+ ++ Sbjct: 462 ------GNFLLT----GAYDNTA--KIWTHPGW--------------------SPLKTLA 489 Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 H V L + +G + + S+D + +LW Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 73.2 bits (178), Expect = 8e-13 Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 26/241 (10%) Query: 512 DACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571 D+C+ W + P ++ GH DAV + FSP+ LAS S D TVRIW Sbjct: 2 DSCLMVWHMK-----------PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50 Query: 572 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLE 630 P+ + + TA+ SV F S + + AS TV ++ L +L Sbjct: 51 VPNVKGESTVFRAHTATVR----SVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSL- 103 Query: 631 SRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPN 690 S + P+ L ++A DD+ ++ D + + VHS H VT + P+ Sbjct: 104 ---SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160 Query: 691 GAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAK 750 G + + D ++++W + +Q H + H A++ ++ HPS + +A +D+ K Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216 Query: 751 V 751 + Sbjct: 217 I 217 Score = 63.9 bits (154), Expect = 5e-10 Identities = 65/292 (22%), Positives = 108/292 (36%), Gaps = 40/292 (13%) Query: 422 DAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKAVTAK 474 D+ W+ K + H D + + F S L + S D T+++W N++ T Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60 Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534 FRAH V +V S+ + + D + W Sbjct: 61 ------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT-----------HRQ 97 Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594 L H + V FSP + + S S D TV++WD SS C G T Sbjct: 98 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVT 153 Query: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 654 V F + I A+ ++D+ L + ++ +N + HP+ IT Sbjct: 154 YVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGNYLIT 208 Query: 655 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 A D ++ LD G+ ++++ H T +A G + SG D + +W Sbjct: 209 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260 Score = 52.4 bits (124), Expect = 2e-06 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%) Query: 414 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468 +C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221 Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519 + ++ H+GP VA EY SGG+D + WK Sbjct: 222 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 73.2 bits (178), Expect = 8e-13 Identities = 85/387 (21%), Positives = 142/387 (36%), Gaps = 86/387 (22%) Query: 418 SDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472 S S D + W+ P FT + H + S+++ L + ++G + LW+ Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190 Query: 473 AKKNAA--------LDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLS 524 + A L EP+HA Y S D + W Sbjct: 191 VGRTLAGHSKWITGLSWEPLHA-------------NPECRYVASSSKDGSVRIW------ 231 Query: 525 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTF 584 D G +L GH +V L + L S S D T+++W + LC Sbjct: 232 -DTTAGR----CERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW---RAHDGVLCR- 281 Query: 585 PTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSS--------G 636 T HG + ST+ A +F + + ++ +L L+ R S G Sbjct: 282 -TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340 Query: 637 PTQ-------------------------------INQVVSHPNQPLTITAHDDRGIRFLD 665 P + INQV+ P+ + +A D+ I+ D Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400 Query: 666 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 725 RTGK + S+ H+ AV +A + L+SGS D +L++W + Q++ H Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----AQKLAMDLPGHA 456 Query: 726 EAIHAVACHPSKALIASAGADALAKVF 752 + ++AV P +AS G D +++ Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/183 (28%), Positives = 84/183 (45%), Gaps = 8/183 (4%) Query: 540 LEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFT 599 LEGH +AV +AFSPT + LAS S D TVR WD S+ +P C H V S+++ Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC---KGHRHWV-LSISW- 164 Query: 600 STEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD-- 657 S + + + ++G +L+D G + + S T ++ H N A Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224 Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717 D +R D G+ + H +VTCL +G L S S D ++++W + + + Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283 Query: 718 TAH 720 H Sbjct: 284 QGH 286 Score = 40.8 bits (94), Expect = 0.005 Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 16/107 (14%) Query: 418 SDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472 S S D K W+ + +LR H + +A+ L++ S D TLK+W+++ Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA--- 445 Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 519 + A+D+ H V AV + + SGG D C+ W+ Sbjct: 446 --QKLAMDLP------GHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484 Score = 38.1 bits (87), Expect = 0.030 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 14/106 (13%) Query: 617 LYDMEVGSAL-LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSM 675 ++D E+ S+L TLES+ + +V+ QP I F + S+ Sbjct: 64 VHDAEIVSSLGKTLESQA----VETEKVLDIIYQPQAI---------FRVRAVTRCTSSL 110 Query: 676 VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 721 H +AV +A P G +L SGS D ++R W L +T HR Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 71.6 bits (174), Expect = 2e-12 Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 22/187 (11%) Query: 450 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI-----HAFRAHRGPVLAVAMGSNSE 504 +S L+T S+D T+KLW L KA+ +K N A D PI R H + +VA+ N + Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSK-NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDK 492 Query: 505 YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSA 564 +G D W +P L V GH +W + FSP Q LA+ SA Sbjct: 493 LLATGSQDRTAKLWALPQCQ-----------LLGVFSGHRRGLWCVQFSPMDQVLATASA 541 Query: 565 DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGS 624 DGT+++W S CL TF VAF S +++S G L+ ++ Sbjct: 542 DGTIKLWALQDFS--CLKTF--EGHDASVLKVAFVS-RGTQLLSSGSDGLVKLWTIKNNE 596 Query: 625 ALLTLES 631 + TL++ Sbjct: 597 CVRTLDA 603 Score = 61.6 bits (148), Expect = 3e-09 Identities = 74/335 (22%), Positives = 127/335 (37%), Gaps = 43/335 (12%) Query: 454 LTASEDGTLKLWNL---QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 510 LTA + GTL++W Q T + E H AH V+ A ++ Y Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322 Query: 511 A-----DACIHSWKIPDLS-MDPYDGY------DPSV--------LSHVLEGHGDAVWGL 550 + +S ++ D+ + P D + P + +L GH D V L Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL 382 Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610 ASC+ D +VRIW + + + H V T V + + + +V Sbjct: 383 DVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT-VCCSRLKESFLVTG- 440 Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGP-------------TQINQVVSHPNQPLTITAHD 657 S D + + ALL+ + +GP IN V PN L T Sbjct: 441 -SQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQ 499 Query: 658 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 717 DR + + + H + C+ P L + S D +++LW+L + +C++ Sbjct: 500 DRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559 Query: 718 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 + H+ ++ VA + S+G+D L K++ Sbjct: 560 ----EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590 Score = 57.0 bits (136), Expect = 6e-08 Identities = 45/157 (28%), Positives = 60/157 (38%), Gaps = 27/157 (17%) Query: 420 SKDAFKKTWN-PKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474 S+D K W P+ L H G+ + F L TAS DGT+KLW LQ Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ------ 551 Query: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534 D + F H VL VA S S G+D + W I + + Sbjct: 552 -----DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN-----------N 595 Query: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571 L+ H D VWGL S + ++D V +W Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632 Score = 51.6 bits (122), Expect = 3e-06 Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 24/140 (17%) Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492 T R H I S+A + L T S+D T KLW L + + + F HR Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQC-----------QLLGVFSGHRR 522 Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLS-MDPYDGYDPSVLSHVLEGHGDAVWGLA 551 + V + + AD I W + D S + ++G+D SVL +A Sbjct: 523 GLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLK------------VA 570 Query: 552 FSPTSQRLASCSADGTVRIW 571 F +L S +DG V++W Sbjct: 571 FVSRGTQLLSSGSDGLVKLW 590 Score = 50.8 bits (120), Expect = 5e-06 Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 40/356 (11%) Query: 418 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472 S + DA + W+ + L +HY + SLAF +L++ D +W+LQ + Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-SCQ 228 Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYD 532 A + + A PV + + S Y + G + W+ Y Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAAS-GQCVYTQAQ 287 Query: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592 P G G + + T+ + + +AD + +++ + S F SE + Sbjct: 288 P-------PGPGQELTHCTLAHTAGVVLTATADHNLLLYE--ARSLRLQKQFAGYSEEVL 338 Query: 593 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP-L 651 V F E +H+V + S +++++ + + G T I + + L Sbjct: 339 --DVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL------HGHTDIVLALDVFRKGWL 390 Query: 652 TITAHDDRGIR-FLDNRTGKP--VHSMVAHLDAV-TCLAVDPNGAFLMSGSHDCSLRLWS 707 + D+ +R + N+ G+ V H +V T +FL++GS DC+++LW Sbjct: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP 450 Query: 708 L-----------DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 L DN + + ++ H++ I++VA P+ L+A+ D AK++ Sbjct: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506 Score = 44.7 bits (104), Expect = 3e-04 Identities = 78/365 (21%), Positives = 119/365 (32%), Gaps = 72/365 (19%) Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496 H + ++AF + + L T DG +++W++ + H FR G V Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGT-----------HHFRGSPGVVHL 156 Query: 497 VAMGSNSE--YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSP 554 VA + +S DA I W + D S VL H AV LAFS Sbjct: 157 VAFHPDPTRLLLFSSATDAAIRVWSLQDRSC-----------LAVLTAHYSAVTSLAFSA 205 Query: 555 TSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV-----PTSVAFTSTEPAHIVAS 609 + S D IWD S + E V P S + + + + Sbjct: 206 DGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265 Query: 610 FRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSH-PNQPLTITA------HDDRGIR 662 G +++ G + T G + ++H LT TA ++ R +R Sbjct: 266 GDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLR 325 Query: 663 F-----------LDNRTGKPVHSMV-----------------------AHLDAVTCLAVD 688 LD R P S V H D V L V Sbjct: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVF 385 Query: 689 PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK-ALIASAGADA 747 G S + D S+R+W + NK A H ++ V C K + + + D Sbjct: 386 RKGWLFASCAKDQSVRIWRM-NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444 Query: 748 LAKVF 752 K++ Sbjct: 445 TVKLW 449 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 71.2 bits (173), Expect = 3e-12 Identities = 117/579 (20%), Positives = 220/579 (37%), Gaps = 69/579 (11%) Query: 184 EVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQ 243 ++ Y I D + + G S + +E +GA P +I Sbjct: 219 DIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPED----------RILSC 268 Query: 244 IKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDED-------DELDSVQHKKQRVKLPS 296 K + ++G++R+ + + + C DS + E+ KK + K Sbjct: 269 RKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMK-KARK 327 Query: 297 KALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGI 356 KA + + E+E+ + ++ D + + + + + + SPH LQ Sbjct: 328 KAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNN 387 Query: 357 LADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCD 416 L +L ++ P P P+P I TIGG D+ L+ ++DN Sbjct: 388 LVELYSLN----------PSLPTPQPVRTSRI--TIGGHR---SDVRTLSFSSDN--IAV 430 Query: 417 LSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSA--------LLTASEDGTLKLWNLQ 468 LS + D+ K WN RS IR++ ++ + ++ ++ G L+L++L Sbjct: 431 LSAAADSIK-IWN-----RSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484 Query: 469 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPY 528 + AH G + ++++ + +GGAD + W + + Sbjct: 485 SG-----------NLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENS 533 Query: 529 DGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTAS 588 SV + V +++SP + LA D TV+I+ + L F + Sbjct: 534 TQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT-----LKFFLSLY 588 Query: 589 EHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPN 648 H +P S + A I + ++ ++ G +L + S + + P Sbjct: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS----VMYLQFVPK 644 Query: 649 QPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708 L TA D I+ D + + ++ H + CLAV P+G +++S SHD SLRLW Sbjct: 645 SHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWER 704 Query: 709 DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADA 747 + + E ++ E +VA A+ D+ Sbjct: 705 TREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDS 743 Score = 42.7 bits (99), Expect = 0.001 Identities = 31/134 (23%), Positives = 59/134 (44%), Gaps = 8/134 (5%) Query: 617 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 676 ++D+ G +L L+ ++ + P+ ++D IR +G+ + Sbjct: 49 IWDLRKGEKILILQGLKQ----EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN 104 Query: 677 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPS 736 H A+T L D G L SGS D + +W + N++ + + K H++AI Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL----KGHKDAITQALFLRE 160 Query: 737 KALIASAGADALAK 750 K L+ ++G D + K Sbjct: 161 KNLLVTSGKDTMVK 174 Score = 38.9 bits (89), Expect = 0.018 Identities = 25/140 (17%), Positives = 50/140 (35%), Gaps = 22/140 (15%) Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492 T H I +L + L + S+D + +W++ ++ ++ + H+ Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV-----------INESGLYRLKGHKD 150 Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552 + + G D + W + D + GH VWGL Sbjct: 151 AITQALFLREKNLLVTSGKDTMVKWWDL-----------DTQHCFKTMVGHRTEVWGLVL 199 Query: 553 SPTSQRLASCSADGTVRIWD 572 +RL + ++D +R+WD Sbjct: 200 LSEEKRLITGASDSELRVWD 219 Score = 36.6 bits (83), Expect = 0.088 Identities = 38/170 (22%), Positives = 68/170 (40%), Gaps = 9/170 (5%) Query: 539 VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 598 +L+G V L SP LA DG++RI+ S T + H + Sbjct: 60 ILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNV-----TFNGHKAAITTLK 114 Query: 599 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDD 658 + + + D +++D+ S L L+ + I Q + + L +T+ D Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDA----ITQALFLREKNLLVTSGKD 170 Query: 659 RGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 708 +++ D T +MV H V L + L++G+ D LR+W + Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220 Score = 34.7 bits (78), Expect = 0.34 Identities = 34/138 (24%), Positives = 56/138 (40%), Gaps = 24/138 (17%) Query: 393 GGGEVSL-GDLADLTVTNDNDLSCDL-SDSKDAFKKTWNP-----KFTLRSHYDGIRSLA 445 G G V+ G A +T + L L S SKD W+ + L+ H D I Sbjct: 97 GEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQAL 156 Query: 446 FHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFR---AHRGPVLAVAMGSN 502 F ++ L+T+ +D +K W D++ H F+ HR V + + S Sbjct: 157 FLREKNLLVTSGKDTMVKWW--------------DLDTQHCFKTMVGHRTEVWGLVLLSE 202 Query: 503 SEYCYSGGADACIHSWKI 520 + +G +D+ + W I Sbjct: 203 EKRLITGASDSELRVWDI 220 >gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] Length = 631 Score = 71.2 bits (173), Expect = 3e-12 Identities = 70/273 (25%), Positives = 113/273 (41%), Gaps = 36/273 (13%) Query: 437 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 496 H D + FH S L T+S D T+KLW+L K + I F H V + Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG-----------DCILTFEGHSRAVWS 441 Query: 497 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 556 S + S D W + + L GH D+V + F P S Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDV-----------NSERCRCTLYGHTDSVNSIEFFPFS 490 Query: 557 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIVASFRS-GD 614 L + SAD T+ IWD + +C S +G S+ +P H++AS + G Sbjct: 491 NTLLTSSADKTLSIWDARTG----IC---EQSLYGHMHSINDAIFDPRGHMIASCDACGV 543 Query: 615 TVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 674 T L+D +++++ GP+ N+V + + A + I LD ++G+ +H Sbjct: 544 TKLWDFRKLLPIVSID----IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHK 598 Query: 675 MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707 ++ H + + +G L SG D ++R WS Sbjct: 599 LMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631 Score = 55.8 bits (133), Expect = 1e-07 Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 38/250 (15%) Query: 466 NLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSM 525 NL + + A D + + FR H PV V+M + + S G D WK+ L Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRL---WKVLGLPK 383 Query: 526 DPYDGYDPSVLSHVLEGHGDAVW--GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCT 583 + +L G G W F P+ +LA+ S D TV++WD C+ T Sbjct: 384 ----------CNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILT 431 Query: 584 FPTASE-------HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG 636 F S H VA +S + + ++D+ TL S Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKT----------SKIWDVNSERCRCTLYGHTDS- 480 Query: 637 PTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 696 +N + P +T+ D+ + D RTG S+ H+ ++ DP G + S Sbjct: 481 ---VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIAS 537 Query: 697 GSHDCSLRLW 706 +LW Sbjct: 538 CDACGVTKLW 547 Score = 38.5 bits (88), Expect = 0.023 Identities = 50/191 (26%), Positives = 72/191 (37%), Gaps = 50/191 (26%) Query: 418 SDSKDAFKKTWNP-----KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 472 S S D K W+ + TL H D + S+ F + LLT+S D TL +W+ + + Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512 Query: 473 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC--IHSWK----IPDLSMD 526 + A RG ++A DAC W +P +S+D Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIA-------------SCDACGVTKLWDFRKLLPIVSID 559 Query: 527 --PYDG----YDPS--VLS------------------HVLEGHGDAVWGLAFSPTSQRLA 560 P G +D S VL+ H L GH + + FS + L Sbjct: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILF 619 Query: 561 SCSADGTVRIW 571 S +DGTVR W Sbjct: 620 SGGSDGTVRTW 630 Score = 36.2 bits (82), Expect = 0.12 Identities = 23/113 (20%), Positives = 50/113 (44%), Gaps = 4/113 (3%) Query: 640 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 699 ++ V P++ + ++ +DR + L + + H D ++ P+G L + S Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414 Query: 700 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752 D +++LW L C+ H + A+ + H +AS+ D +K++ Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSR----AVWSCTWHSCGNFVASSSLDKTSKIW 463 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 71.2 bits (173), Expect = 3e-12 Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 37/316 (11%) Query: 435 RSHYDGIRSLAF----HHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 490 ++H D I S+A+ + ++T S D +K+W ++ LD++ + H Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGH 63 Query: 491 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 550 + V++V + S DA I W + + + + G DA W L Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQ----------IKSIDAGPVDA-WTL 112 Query: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610 AFSP SQ LA+ + G V I+ S + + S+A+ S + ++ + Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKE----YSLDTRGKFILSIAY-SPDGKYLASGA 167 Query: 611 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670 G ++D+ G L TLE G + P I + P+ L +TA DD I+ D + Sbjct: 168 IDGIINIFDIATGKLLHTLE--GHAMP--IRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223 Query: 671 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHA 730 ++ H V +A P+ +S S D S+++W + +TCV H++ + Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF----DHQDQVWG 279 Query: 731 VACHPSKALIASAGAD 746 V + + + I S G D Sbjct: 280 VKYNGNGSKIVSVGDD 295 Score = 64.3 bits (155), Expect = 4e-10 Identities = 62/297 (20%), Positives = 124/297 (41%), Gaps = 38/297 (12%) Query: 417 LSDSKDAFKKTW-------NPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQK 469 ++ S D K W + +++L H G+ S+ H+ ++S D ++LW+L+ Sbjct: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95 Query: 470 AVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYD 529 K+ ++D P+ A+ +A +S+Y +G H K+ Sbjct: 96 G---KQIKSIDAGPVDAW--------TLAFSPDSQYLATG-----THVGKVNIF------ 133 Query: 530 GYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 589 G + + L+ G + +A+SP + LAS + DG + I+D ++ T Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK-----LLHTLEG 188 Query: 590 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 649 H +P S + +V + G +YD++ + TL S + V P+ Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHAS----WVLNVAFCPDD 244 Query: 650 PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706 +++ D+ ++ D T VH+ H D V + + NG+ ++S D + ++ Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301 Score = 51.6 bits (122), Expect = 3e-06 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%) Query: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492 TL H IRSL F L+TAS+DG +K++++Q A A H Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA-----------GTLSGHAS 233 Query: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552 VL VA + + S +D + W + H H D VWG+ + Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDV-----------GTRTCVHTFFDHQDQVWGVKY 282 Query: 553 SPTSQRLASCSADGTVRIWD 572 + ++ S D + I+D Sbjct: 283 NGNGSKIVSVGDDQEIHIYD 302 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.132 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,107,496 Number of Sequences: 37866 Number of extensions: 2089725 Number of successful extensions: 29442 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 456 Number of HSP's successfully gapped in prelim test: 766 Number of HSP's that attempted gapping in prelim test: 16932 Number of HSP's gapped (non-prelim): 9565 length of query: 753 length of database: 18,247,518 effective HSP length: 110 effective length of query: 643 effective length of database: 14,082,258 effective search space: 9054891894 effective search space used: 9054891894 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.