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Search of human proteins with 13787217
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
(4349 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 8740 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 3547 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 3305 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 1095 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 869 0.0
gi|16933557 dachsous 1 precursor [Homo sapiens] 802 0.0
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 660 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 407 e-112
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 394 e-109
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 378 e-104
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 362 3e-99
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 270 3e-71
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 266 3e-70
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 266 3e-70
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 266 3e-70
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 266 3e-70
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 266 3e-70
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 266 3e-70
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 266 3e-70
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 266 3e-70
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 266 3e-70
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 266 3e-70
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 254 1e-66
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 249 5e-65
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 249 5e-65
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 248 9e-65
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 248 9e-65
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 248 9e-65
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 248 1e-64
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 248 1e-64
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 8740 bits (22678), Expect = 0.0
Identities = 4349/4349 (100%), Positives = 4349/4349 (100%)
Query: 1 MTIALLGFAIFLLHCATCEKPLEGILSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGI 60
MTIALLGFAIFLLHCATCEKPLEGILSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGI
Sbjct: 1 MTIALLGFAIFLLHCATCEKPLEGILSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGI 60
Query: 61 YLAEPQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQ 120
YLAEPQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQ
Sbjct: 61 YLAEPQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQ 120
Query: 121 ATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQN 180
ATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQN
Sbjct: 121 ATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQN 180
Query: 181 AEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLA 240
AEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLA
Sbjct: 181 AEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLA 240
Query: 241 ALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHF 300
ALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHF
Sbjct: 241 ALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHF 300
Query: 301 KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSL 360
KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSL
Sbjct: 301 KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSL 360
Query: 361 KFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL 420
KFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL
Sbjct: 361 KFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL 420
Query: 421 MDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAV 480
MDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAV
Sbjct: 421 MDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAV 480
Query: 481 TATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGS 540
TATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGS
Sbjct: 481 TATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGS 540
Query: 541 PFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYE 600
PFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYE
Sbjct: 541 PFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYE 600
Query: 601 IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK 660
IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK
Sbjct: 601 IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK 660
Query: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQ 720
DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQ
Sbjct: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQ 720
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDY 780
SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDY
Sbjct: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDY 780
Query: 781 EATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA 840
EATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA
Sbjct: 781 EATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA 840
Query: 841 ELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPS 900
ELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPS
Sbjct: 841 ELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPS 900
Query: 901 KGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEV 960
KGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEV
Sbjct: 901 KGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEV 960
Query: 961 RYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV 1020
RYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV
Sbjct: 961 RYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV 1020
Query: 1021 LDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF 1080
LDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF
Sbjct: 1021 LDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF 1080
Query: 1081 SINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQA 1140
SINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQA
Sbjct: 1081 SINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQA 1140
Query: 1141 VFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQL 1200
VFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQL
Sbjct: 1141 VFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQL 1200
Query: 1201 DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP 1260
DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP
Sbjct: 1201 DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP 1260
Query: 1261 GPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILTIKATD 1320
GPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILTIKATD
Sbjct: 1261 GPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILTIKATD 1320
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF
Sbjct: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
Query: 1381 WFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIAN 1440
WFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIAN
Sbjct: 1381 WFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIAN 1440
Query: 1441 INHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLD 1500
INHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLD
Sbjct: 1441 INHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLD 1500
Query: 1501 PSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHY 1560
PSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHY
Sbjct: 1501 PSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHY 1560
Query: 1561 EASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQ 1620
EASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQ
Sbjct: 1561 EASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQ 1620
Query: 1621 ANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPIL 1680
ANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPIL
Sbjct: 1621 ANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPIL 1680
Query: 1681 LVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFT 1740
LVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFT
Sbjct: 1681 LVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFT 1740
Query: 1741 DVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLL 1800
DVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLL
Sbjct: 1741 DVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLL 1800
Query: 1801 VYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVII 1860
VYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVII
Sbjct: 1801 VYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVII 1860
Query: 1861 HVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAVTIHP 1920
HVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAVTIHP
Sbjct: 1861 HVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAVTIHP 1920
Query: 1921 VTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980
VTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKEN
Sbjct: 1921 VTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980
Query: 1981 LQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAV 2040
LQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAV
Sbjct: 1981 LQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAV 2040
Query: 2041 EVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLG 2100
EVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLG
Sbjct: 2041 EVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLG 2100
Query: 2101 TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVL 2160
TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVL
Sbjct: 2101 TNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVL 2160
Query: 2161 VTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDF 2220
VTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDF
Sbjct: 2161 VTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDF 2220
Query: 2221 KTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTS 2280
KTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTS
Sbjct: 2221 KTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTS 2280
Query: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE 2340
ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE 2340
Query: 2341 AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLK 2400
AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLK
Sbjct: 2341 AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLK 2400
Query: 2401 VQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV 2460
VQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV
Sbjct: 2401 VQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV 2460
Query: 2461 FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI 2520
FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI
Sbjct: 2461 FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI 2520
Query: 2521 INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND 2580
INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND
Sbjct: 2521 INKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDEND 2580
Query: 2581 NPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVT 2640
NPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVT
Sbjct: 2581 NPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVT 2640
Query: 2641 GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA
Sbjct: 2641 GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST
Sbjct: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
Query: 2761 KLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
KLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT
Sbjct: 2761 KLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
Query: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDH 2880
AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDH
Sbjct: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDH 2880
Query: 2881 GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR 2940
GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR
Sbjct: 2881 GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR 2940
Query: 2941 QVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIF 3000
QVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIF
Sbjct: 2941 QVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIF 3000
Query: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL
Sbjct: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
Query: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAV 3120
DPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAV
Sbjct: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAV 3120
Query: 3121 AVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQ 3180
AVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQ
Sbjct: 3121 AVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQ 3180
Query: 3181 APLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL 3240
APLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL
Sbjct: 3181 APLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL 3240
Query: 3241 ATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSS 3300
ATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSS
Sbjct: 3241 ATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSS 3300
Query: 3301 LSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSL 3360
LSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSL
Sbjct: 3301 LSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSL 3360
Query: 3361 IGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVN 3420
IGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVN
Sbjct: 3361 IGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVN 3420
Query: 3421 DNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD 3480
DNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD
Sbjct: 3421 DNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD 3480
Query: 3481 GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITV 3540
GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITV
Sbjct: 3481 GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITV 3540
Query: 3541 GEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSF 3600
GEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSF
Sbjct: 3541 GEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSF 3600
Query: 3601 NVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLD 3660
NVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLD
Sbjct: 3601 NVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLD 3660
Query: 3661 IKRANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRS 3720
IKRANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRS
Sbjct: 3661 IKRANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRS 3720
Query: 3721 AMPMVPCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNGTATRFSG 3780
AMPMVPCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNGTATRFSG
Sbjct: 3721 AMPMVPCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNGTATRFSG 3780
Query: 3781 QSYVRYRAPAARNWHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGN 3840
QSYVRYRAPAARNWHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGN
Sbjct: 3781 QSYVRYRAPAARNWHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGN 3840
Query: 3841 LSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLH 3900
LSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLH
Sbjct: 3841 LSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLH 3900
Query: 3901 SSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGG 3960
SSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGG
Sbjct: 3901 SSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGG 3960
Query: 3961 KCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDR 4020
KCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDR
Sbjct: 3961 KCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDR 4020
Query: 4021 CEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRCKSHKPVA 4080
CEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRCKSHKPVA
Sbjct: 4021 CEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRCKSHKPVA 4080
Query: 4081 MEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPV 4140
MEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPV
Sbjct: 4081 MEDPDLLARSVGVDTQAMPAIELNPLSASSCNNLNQPEPSKASVPNELVTFGPNSKQRPV 4140
Query: 4141 VCSVPPRLPPAAVPSHSDNEPVIKRTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQ 4200
VCSVPPRLPPAAVPSHSDNEPVIKRTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQ
Sbjct: 4141 VCSVPPRLPPAAVPSHSDNEPVIKRTWSSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQ 4200
Query: 4201 GPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMPSRPPSPR 4260
GPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMPSRPPSPR
Sbjct: 4201 GPLPPSAHRHSTPVVMPEPNGLYGGFPFPLEMENKRAPLPPRYSNQNLEDLMPSRPPSPR 4260
Query: 4261 ERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLA 4320
ERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLA
Sbjct: 4261 ERLVAPCLNEYTAISYYHSQFRQGGGGPCLADGGYKGVGMRLSRAGPSYAVCEVEGAPLA 4320
Query: 4321 GQGQPRVPPNYEGSDMVESDYGSCEEVMF 4349
GQGQPRVPPNYEGSDMVESDYGSCEEVMF
Sbjct: 4321 GQGQPRVPPNYEGSDMVESDYGSCEEVMF 4349
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 3547 bits (9198), Expect = 0.0
Identities = 1849/4086 (45%), Positives = 2651/4086 (64%), Gaps = 92/4086 (2%)
Query: 26 LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85
L + FTH YN T+ ENS+ KTYV KMG+Y+ P W VRY+I+SGD N+FK E
Sbjct: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
Query: 86 EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLK 145
EY++G+FCFLRIRTK NTA+LNREV+D YTLI++A EK +EA T+V V +LD NDL+
Sbjct: 87 EYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLR 146
Query: 146 PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTV 205
PLFSP SY V++ E+ +++ I +V+ATDAD+G N EFYY+F R++MFAIHPTSGV+ +
Sbjct: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVL 206
Query: 206 AGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPD 265
G+L+ +E+++LA DR K+ +G S+A L VH+E A P I +V ++P +
Sbjct: 207 TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSE 266
Query: 266 SNDGTTYATVLVDANSSGA--EVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM 323
+ YA V VD GA ++ S+ +V GD + F+ ++S+ S E+ + ++ I+W
Sbjct: 267 LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWD 326
Query: 324 EYLHGFNLSLQARSGSGPYFYSQIRGFHL--PPSKLSSLKFEKAVYRVQLSEFSPPGSRV 381
+ G+NL+LQA+ P +S ++ H+ P K +KFEK VYR ++SEF+PP + V
Sbjct: 327 SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Query: 382 VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQAS 441
VMV+ PA+ +L+YV K + F LN TGLI+ + + AH++L + TS +AS
Sbjct: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKAS 446
Query: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
T V++ ++ N++ P F +++Y DEN+P GT+V++++A D D GENGYVTYSIA
Sbjct: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLN 506
Query: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
+PF+ID + G +STS+ +DYELM R+YT R+RASDWG P+RRE EV + L NLNDN
Sbjct: 507 HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566
Query: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISL 621
P+FE++NC G+I +D VG+ I T+SAID DELQ ++Y+I +GNEL++F LN SGV+SL
Sbjct: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626
Query: 622 KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681
KR ++ + + +SL+ITA+DG+N+A+P +NITV H V + C++TGV +
Sbjct: 627 KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAAS-HKLVNLQCEETGVAKMLAE 685
Query: 682 TILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATD 741
+L L NQ ++ F ++ +N + PQF P I V E+ P+ + + + +TD
Sbjct: 686 KLLQANKLHNQGEVEDIF--FDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTD 743
Query: 742 PDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKS 801
D GFNGKLVY ++ GNE+ CF I++ETG+L + +PLD E T+ Y LN+TVYDLG PQK+
Sbjct: 744 LDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA 803
Query: 802 SWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLS 861
+W+LL V V D NDN P F Y + +SED EV + I ++ D D NG V Y++++
Sbjct: 804 AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT 863
Query: 862 PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDN 921
T+ FS+ +TG + + LDRE + + LK+EARDQ + QLFS + ++LEDVNDN
Sbjct: 864 DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
Query: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGAL 981
P I + R+KV EDLP GTV+ +L+A DPDLG +G+VRY L+D G F VD ++GA+
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAV 983
Query: 982 ILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQV 1041
+ ++LDFE++ YNL++ A D G+P++ + C+VEV V+DVNENLHPP F+SFV +G V
Sbjct: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTV 1043
Query: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFAS 1101
+E++P G+ V+ V+A D+D+ DGE++Y +R G+G+ F I ++TG+I+T LDRE S
Sbjct: 1044 KEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTS 1103
Query: 1102 YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDA 1161
+YWLTV A D+G VPLSS E+YIEV D NDN PQ S+ V+YP I E++P SV+Q++A
Sbjct: 1104 HYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEA 1163
Query: 1162 WDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLL-STAQQLDRENKDEHILEVTVLDNGEP 1220
+DPDSSS KL + ITSGN GFF IHP TGL+ +T+++LDRE +DEHILEVTV DNG P
Sbjct: 1164 FDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP 1223
Query: 1221 SLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSP-----VSPGPVYRLVASDLDEGL 1275
+ +RV+V ILD NDN P F K + +RLPER P P+Y ++A+D DEG
Sbjct: 1224 PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGP 1283
Query: 1276 NGRVTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHI 1334
N ++YSIED +E F I+ TGVVSS AGEY+IL+IKA D+G+P S++ RLHI
Sbjct: 1284 NAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI 1343
Query: 1335 EWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGL-FWFNISGGDKDMDF 1393
EWI P+PS P++F+E++++FTVME+DPV HM+GVISVE PG+ WF+I+GG+ D F
Sbjct: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVE-PPGIPLWFDITGGNYDSHF 1402
Query: 1394 DIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRY 1453
D++K TG+I++A+PLD ++SNYNLTVE TDG+ TI TQV I +I + N HRPQF ++Y
Sbjct: 1403 DVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVI-DTNDHRPQFSTSKY 1461
Query: 1454 EVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLD 1513
EV +P+DT P E+L++ A+DQD+ LIYT+ S+DP S F+LDP++G L T KLD
Sbjct: 1462 EVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLD 1521
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
QHTLTVMVRDQ++P+KRNF + ++V D N H P FT Y+ V ++ A G+
Sbjct: 1522 -HEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSV 1580
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
+LQV A+D D+G NAEV YS+ GN F I+ +LG I A++LD++N A + L VKA
Sbjct: 1581 VLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKAT 1640
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE 1693
D+GSP ++ +V I V +D ++P F+ EY VE+ E++ +GS + +V+A S S V YE
Sbjct: 1641 DKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYE 1700
Query: 1694 LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDEND 1753
+++GN F +N +SG I TQK LD E + Y L I+G+NMAG T+ V+V + DEND
Sbjct: 1701 IKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
Query: 1754 NAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFF 1813
NAP+F+++ + G ISE+A + S+++ N P VI A+D+DK++N+LLVY I+EP +F
Sbjct: 1761 NAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYF 1820
Query: 1814 KIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFS 1873
ID S G + V +DYE F F V VHD G+P LFA A V +HV D+ND PP F+
Sbjct: 1821 AIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFA 1880
Query: 1874 EQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVLN 1929
+ +YE +++ P + G++++ V A+D D S++ YSI GN E ++ TG+++V N
Sbjct: 1881 KPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQN 1940
Query: 1930 PAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVI 1989
L +LT+RASDG + VKI++ + + L+F QDVY A VKEN + + L +
Sbjct: 1941 TTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAV 2000
Query: 1990 LGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
+ A GN +N+ L Y +LN F + +++GVL T G FDREQQ+ ++ VEV + P
Sbjct: 2001 ITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPS 2060
Query: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
VA +V+V +ED NDN P F +LPYY +++ TE G V+ V+A D D G NG V Y
Sbjct: 2061 AVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL 2120
Query: 2110 AEDYTYFRIDPYLGDISLKKPFDYQALNK-YHLKVIARDGGTPSLQSEEEVLVTVRNKSN 2168
E + +F+I P LG+ISLKK F+ LNK Y + V+A+DGG P+ +E V +TV NK+
Sbjct: 2121 KEHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAM 2179
Query: 2169 PLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVT 2228
P+F+ P+Y + E+I +++P++H QA SPEGL++ Y+I + +P FT +F TGV+ V
Sbjct: 2180 PVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVI 2239
Query: 2229 GPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288
PLD+E+ + ++RATD+ G+ +E V+++V+D+NDNPP F+Q Y ++SE
Sbjct: 2240 APLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG 2299
Query: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348
T V+Q+ A+D DS NR +SYQ+ + S F ++ STG +S ++ LDYE + +
Sbjct: 2300 TSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIF 2359
Query: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408
VRA+D G P L+ + +V V+V+D+NDNPP F Q YEA +SE A GH V V+A D DS
Sbjct: 2360 VRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADS 2419
Query: 2409 RDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVY 2468
D +L+Y ILSGN +HF I+S++GII++ NL + L Y+L + SDGVFR++ V+
Sbjct: 2420 SDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVH 2479
Query: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528
+ N +SP F Q+ YE ELAENA + T V+++ D DSG YG + Y I+N A ++
Sbjct: 2480 VTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDR 2539
Query: 2529 FSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKAS 2588
F IN GQI TL+KLDRE E+VI++++MA+D GG+VAFCTV +ILTD+NDN PQF+A+
Sbjct: 2540 FYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRAT 2599
Query: 2589 EYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPE-DLVKDVIEINPVTGVVKVKD 2647
+Y V+I S+ +K + V++VLA DADEG NAD+TY++ + + VK+ +EIN ++GV+ K+
Sbjct: 2600 KYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKE 2659
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEG 2707
SL+GLEN+ FF++A D G P S+V V ++++P ++ LPKFSEP YTF+ ED+P G
Sbjct: 2660 SLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG 2719
Query: 2708 SEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDV 2767
+EI +++A V+YSLV+G TPESN+D F +D +G +K+ K +DHE+TK YQ +
Sbjct: 2720 TEIDLIRA-EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI 2778
Query: 2768 MAHCLQNT-DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDT 2826
+A C Q+ ++V+ V V+IQV D NDN PVFE+ PY+A + EN+P G+ VIQ+ A D D+
Sbjct: 2779 LARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADS 2838
Query: 2827 GRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL 2886
G +GQV Y L V E FAI+ E+GWITTL+ELD E Y VVA DHG+ IQL
Sbjct: 2839 GTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQL 2898
Query: 2887 SSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYI 2946
SS A+V V++TD ND+ PRF +E Y+G+V E+ G ++A L T DAD E NRQVT +I
Sbjct: 2899 SSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFI 2958
Query: 2947 TEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVND 3006
T GDPLGQF + + +EW++ +K LDRE YLL +TA+DG F + VE+ VLD ND
Sbjct: 2959 TGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDAND 3018
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGE 3066
NSP C + LY+ + EDV PG I+++SATD D +NA+ITY+L G GA +FKL+P TGE
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE 3078
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
L T T LDRE + V++L+ +ATDGGGR CQA I L +EDVNDNAP F A+ VF+NT
Sbjct: 3079 LKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENT 3138
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
T + V A D D G N +++YSL DSA+G FSI+ +G+I+LEKPL QA L+
Sbjct: 3139 EPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLS 3198
Query: 3187 VRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR- 3245
++A D G P L+ GTV VSV+ + D PVF E+ V ED GTEVLQ+ +R
Sbjct: 3199 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD 3258
Query: 3246 --PGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSD 3303
AE T Y ++SGNE G+F +D++TG +++ +LD+E+S +Y+L++E + + SLSD
Sbjct: 3259 IEANAEIT-YSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSD 3317
Query: 3304 VTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGG 3363
V TV VN+TD+N++ P F QD Y+T + E+A++ ++TV A D DGP NS I YS+I G
Sbjct: 3318 VATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDG 3377
Query: 3364 NQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423
NQ FTI P +GE++V K LDRE S Y+L ++A+D+G PP T + I V+DVNDN
Sbjct: 3378 NQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNA 3437
Query: 3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWL 3483
P F + NYS +QEN P+G VLQL+++D DS NGPP+ F I GN+ AF V P G L
Sbjct: 3438 PVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVL 3497
Query: 3484 VTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGED 3543
+T+ + R+ ++ Y LQ++ +D+G P LSSLT + + V E+S Y P+ LPLEIFIT +
Sbjct: 3498 LTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGE 3557
Query: 3544 EFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVT 3603
E+ GG++GKIHATD+D DTLTYSL + + FSV + GK+IA + L G Y NV+
Sbjct: 3558 EYSGGVIGKIHATDQDVYDTLTYSL--DPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVS 3615
Query: 3604 VSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLDIKR 3663
V+DG FTT A + V++ V QE L + + F LTPEE V D+WRN QR L + L ++R
Sbjct: 3616 VTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRR 3675
Query: 3664 ANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMP 3723
+I + SLQ +E +DVLL E ++L I S ++E +GV++ +
Sbjct: 3676 NDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQ 3735
Query: 3724 MVPCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSC------------ 3771
+ C G C + C V +D V T+STARLS +TPRHH C C
Sbjct: 3736 KL-CAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHGC 3794
Query: 3772 ---------------------------------NGTATRFSGQSYVRYRAPAARN---WH 3795
++ +G SYV+YR N
Sbjct: 3795 EDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKYRLTENENKLEMK 3854
Query: 3796 IHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGNLSSQR-HVNDHEWHS 3854
+ L+T A++++ T L++ G Q ++ C G G +S Q VND +WH+
Sbjct: 3855 LTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDC-GSGPGIVSVQSIQVNDGQWHA 3913
Query: 3855 ILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHS-----SSNVSQGF 3909
+ +E RL++D + S P + L + ++ GG I S V GF
Sbjct: 3914 VALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGF 3973
Query: 3910 EGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCL--HSDYCSQNTCLNGGKCSWTHG 3967
GC+D++ +N + L L + ++ A + E+ ++ C ++ C+ N C NGG C+ +
Sbjct: 3974 RGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPCQNGGVCNPSPA 4033
Query: 3968 AGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG 4027
GY CKC + G HCE C+ PCL GGTC++ G C C YTG RC++
Sbjct: 4034 GGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSPY- 4092
Query: 4028 CSEGHC 4033
C + C
Sbjct: 4093 CKDEPC 4098
Score = 90.9 bits (224), Expect = 2e-17
Identities = 102/402 (25%), Positives = 148/402 (36%), Gaps = 109/402 (27%)
Query: 3943 QCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCI 4002
Q C S YC C NGG C + G VC+C F G+ C+ + C+ PCL G C
Sbjct: 4085 QRCQLSPYCKDEPCKNGGTC-FDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCE 4143
Query: 4003 LSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIIS 4062
+ CNC H Y G CE + + TP + G E + I V VA I +
Sbjct: 4144 NTHGSYHCNCSHEYRGRHCE----DAAPNQYVSTP----WNIGLAEGIGIVVFVAGIFLL 4195
Query: 4063 TVGLLFYCRRCKSHKPVAMEDPD---------LLAR-------SVGVDTQAMPAIELNPL 4106
V + CR+ S K +P L R + + + P + + P+
Sbjct: 4196 VV-VFVLCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPI 4254
Query: 4107 S------ASSCNNLNQPEPSKASVPN--ELVTFGPNS----KQRPVVCSVPPRLPPAAVP 4154
S + S NNL++ +++P E TF P S ++ VCSV P LPP
Sbjct: 4255 SYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPS 4314
Query: 4155 -SHSDNEPVIKRTW---------------------------------------------- 4167
S SD++ + K +W
Sbjct: 4315 NSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSE 4374
Query: 4168 SSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGL----Y 4223
S ++ Y W P+ + E+P+ EV TP+ +PN + Y
Sbjct: 4375 SCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVID---------EQTPLYSADPNAIDTDYY 4425
Query: 4224 GG-------FPFPLE---MENKRAPLPPRYSNQNLEDLMPSR 4255
G FP P E ++ PLPP +SNQ E + P R
Sbjct: 4426 PGGYDIESDFPPPPEDFPAADELPPLPPEFSNQ-FESIHPPR 4466
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 3305 bits (8570), Expect = 0.0
Identities = 1853/4432 (41%), Positives = 2635/4432 (59%), Gaps = 217/4432 (4%)
Query: 31 WHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVG 90
+HFTHS YNAT+YENS+ +TYV S +MGI L + W ++YRI+SGD FK EE ++
Sbjct: 41 FHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIA 100
Query: 91 NFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSP 150
+FCFLRIRTK N+A+LNRE++D+Y LI++ + + +LEA T+V + +LD NDL+PLFSP
Sbjct: 101 DFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSP 160
Query: 151 PSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLN 210
+Y VTI+E PL++ + +VTATDAD+G N EFYY F + ++F++HPTSGV++++G+LN
Sbjct: 161 TTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLN 220
Query: 211 VTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGT 270
+ +++L++LAVDR K+ NG S A L VH+E P I V P
Sbjct: 221 YDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEP 280
Query: 271 TYATVLVDANSSGA--EVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHG 328
TYA V VD GA E+ESV +V GDP F K NE+ + K I+W + +G
Sbjct: 281 TYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYG 340
Query: 329 FNLSLQARSGSGPYFYSQIRGFHL--PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRV 386
+NL+LQA+ P S ++ ++ P ++FEK VY V +SEFSPPG V +V++
Sbjct: 341 YNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
Query: 387 TPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVI 446
+P +++Y L P + V FK+N R+GLI T + ++ + Y+L + G V I
Sbjct: 401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTI 460
Query: 447 DIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFS 506
I D N+H P F + YD ++E++P GTSVL V+A+D+D GENGY+TYSIA LPF
Sbjct: 461 SIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFV 520
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEE 566
I+ + G+IST++ +D+E IY F VRASDWGSP+R E EV++ +++ N+NDN P+FE+
Sbjct: 521 INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
Query: 567 VNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFI 626
V C G I D+PVG I +SAID+DEL+ +KY+I+SGNEL +F LN SGV+ LK+
Sbjct: 581 VACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
Query: 627 NLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHF 686
N + + +++L+ITA+DG+N A P ++NI+V+ +C +T V + + +L
Sbjct: 641 N-SGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
Query: 687 IGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGF 746
+ + ++ F L Y IN P F+ FP + V E +P+ + ++ A D D+GF
Sbjct: 700 AKANGKLNLEDGF--LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGF 757
Query: 747 NGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLL 806
NGK+++ I+DGN + CF+I++ETG L V P+D E T+ Y+LN+T+YDLG PQKSSW+LL
Sbjct: 758 NGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLL 817
Query: 807 TVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKF 866
T+NV+D NDN+P F Y + I E + +GT I ++ +D D NG V Y++L+ T++F
Sbjct: 818 TINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQF 877
Query: 867 SLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCI 926
+++ TG + V LDRES+ Y LK+EARD+ G QLFSV L + L+DVND SP I
Sbjct: 878 AINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
Query: 927 TEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERE 986
+KV EDLP GTV+ +L+ DPDLG G+VRY L++ +G F +D +GA+ L +E
Sbjct: 938 PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKE 997
Query: 987 LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSP 1046
LD+E++ YNL++ A D GRP++ ++ VEV V+DVNENLH P+F F G V+ENS
Sbjct: 998 LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSR 1057
Query: 1047 SGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLT 1106
GT V+ V A+D+DSG DGE+QY +R G+GL FSI+ ++G+I LDRE YWLT
Sbjct: 1058 IGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLT 1117
Query: 1107 VLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
V A DRG VPL S EVYIEV D NDN P S+ ++YP + E++P SV+Q+ A DPDS
Sbjct: 1118 VYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDS 1177
Query: 1167 SSKGKLTFNITSGNYMGFFMIHPVTGLL-STAQQLDRENKDEHILEVTVLDNGEPSLKST 1225
SS KLT+ ITSGN FF I+ TGL+ +T+++LDRE + EH LEVTV D G +ST
Sbjct: 1178 SSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQST 1237
Query: 1226 SRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIED 1285
VVV +LD NDN P F K++ ++LPER P+YR A D DEG N ++YSI D
Sbjct: 1238 IWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVD 1297
Query: 1286 -SDEEAFSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSS 1344
+D+ F ID TG+VSS FTAG Y+ILTIKA D+G+P S++ RLHIEWI P PS
Sbjct: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSP 1357
Query: 1345 IPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404
IPL FDE +Y+FTVME+D V +VGV+SV+ WF+I GG+ D FD EK G+IVI
Sbjct: 1358 IPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
Query: 1405 ARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPG 1464
A+PLD +RS YN++VEVTDG+ TQV I ++ N N + P+F + Y+V + +D +P
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDN-NDNGPEFSQPNYDVTISEDVLPD 1476
Query: 1465 VELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLT 1524
E+L+++A D+D+ L YT+H S D S F++DPS+GVL T +LD +H L
Sbjct: 1477 TEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLD-HEAQDKHILN 1535
Query: 1525 VMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADR 1584
+MVRDQE P +RN V ++VED N H P FT YEASV ++ A G+ +LQV A+D D+
Sbjct: 1536 IMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDK 1595
Query: 1585 GVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLA 1644
G NAE+ Y++ GN+ F I +LGIIT+ ++ D L++K DQGSP A
Sbjct: 1596 GENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATA 1655
Query: 1645 TVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVFS 1704
V I V SD S P F +Y E+ E++ +G+ ++L+SA+S S + YE+++G+ +G+F+
Sbjct: 1656 IVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIFT 1715
Query: 1705 MNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFV 1764
+N YSG+I+TQK LD+E+ SSYQL I+ +NMAG ++ V + I+DENDNAP+FL S +
Sbjct: 1716 INPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYS 1775
Query: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI 1824
G +SEAAP+ S++ +N+P VI A+D+D N+LLVY+I+E A KFF +D S G +
Sbjct: 1776 GSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRT 1835
Query: 1825 VSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGP 1884
++ +D+E++ F F V+V D GSP L A P +V I V DVND+PP F++ ++E ++ P
Sbjct: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP 1895
Query: 1885 IHPGMELLMVRASDEDSEV----NYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT 1940
+ G+E+L V A+D DSEV YS+ G+ D + I +G +++ N L
Sbjct: 1896 TYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVLTIKNNNLSKDHYMLI 1954
Query: 1941 IRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDT 2000
++ SDG + T++V I + + +D L F Q Y ++ EN + + I+ A GN LN+
Sbjct: 1955 VKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEP 2014
Query: 2001 LSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI 2060
L Y +LN + F + ++GV+QT GV FDRE+Q+ +EL VE RVA+ +VRV+I
Sbjct: 2015 LKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNI 2074
Query: 2061 EDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDP 2120
ED+NDN P F LPYY +Q EPG +++QV+A D+D G NG VTY +DY +F I+P
Sbjct: 2075 EDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINP 2134
Query: 2121 YLGDISLKKPFDYQALN-KYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVR 2179
G++ LK+ F+ N +Y + ++A+DGG PSL + E+ +T+ NK+ P+F P+Y
Sbjct: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTAS 2194
Query: 2180 VPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKH 2239
V E+I + TPIL A SPEG +IY I++ +P F DF TGVL V PLDYE + +
Sbjct: 2195 VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQ 2299
T+RA+D G+ +E TV++LV DVNDNPP F Q Y T++SE TPV+Q+++ D
Sbjct: 2255 KLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDA 2314
Query: 2300 DSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPL 2359
DS N+ V YQIV+D + + +F I+ S+G + T + LD+E QH +KVR++D G P L
Sbjct: 2315 DSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSL 2374
Query: 2360 TGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLIL 2419
+ E LV + +SD+NDNPP F Q YE+ VSELA GH V VQA D DS D RLEY IL
Sbjct: 2375 SSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL 2434
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSP 2479
SGN F ++S SG+I++ N K+ ++ Y+L V SDG+F +T V+I AN YSP
Sbjct: 2435 SGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSP 2494
Query: 2480 EFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIAT 2539
F Q Y AE+ EN GTKVI + A D D G YG I Y IIN A ++F I+ NGQ+ T
Sbjct: 2495 AFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVIT 2554
Query: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVS 2599
++LDREN E ++I V A DGGGR FCTV++I+ DENDN PQF EY S++++V
Sbjct: 2555 TERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
Query: 2600 KDSPVIQVLAYDADEGQNADVTYSVNPEDLVK--DVIEINPVTGVVKVKDSLVGLENQTL 2657
+ V QV A D D+G N+ +TYS+ E V D++EI+P G + K + L+N L
Sbjct: 2615 RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVL 2674
Query: 2658 DFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVA 2717
FF+KA DGG P +SL+PV + V+P + LP F++ Y+F+ ED GS + ++ +
Sbjct: 2675 SFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILP 2734
Query: 2718 AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHC-LQNTD 2776
+Q+ V +S V G PE+NK G+F ++ +TG IK+ K +D E++ + V A L D
Sbjct: 2735 SQN-VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVD 2793
Query: 2777 VVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL 2836
+V V V+I+V D+NDN+PVFE Y ++ E MPVGT + QV AID D G +GQV+Y L
Sbjct: 2794 IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSL 2853
Query: 2837 SAD-PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVS 2895
+D V E F IDS +GWI+TL++LD ET T+ F VVA D G+ LSS ALV V
Sbjct: 2854 HSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVR 2913
Query: 2896 ITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQF 2955
+TD NDNAP FA E YRG+V E+ PGE+VA L T D D S+ NRQV+ +IT G+P G+F
Sbjct: 2914 VTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF 2973
Query: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLL 3015
+ V EW++ ++ LDRE Y L +TA+DG F VE+ V DVNDNSP C Q+
Sbjct: 2974 ALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVA 3033
Query: 3016 YTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDR 3075
YT + ED+ ILKVSA D D +N I YSL+G G EF LDP +GEL TL LDR
Sbjct: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDR 3093
Query: 3076 ERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV 3135
ER V++L+AKATDGGGR CQ++I L +EDVNDN P F H V++NT K + V
Sbjct: 3094 ERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRV 3153
Query: 3136 FARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
A DPD G N +VVYSL DSA G FSID+++G+I LE+PL Q+ ++VRA+D
Sbjct: 3154 QAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPG 3213
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR---PGAEKTG 3252
LS+L TVT++V+ + D PVF ++ V VPED PGT+VL + ++ AE T
Sbjct: 3214 QSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT- 3272
Query: 3253 YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNIT 3312
Y + SGNEQG+F+++ +TG + V+ LD+E +++L +E + +LS V TV +N+T
Sbjct: 3273 YLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLT 3332
Query: 3313 DVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIH 3372
DVN++ P+F QD YS + E+ALVGD ++ + A D D N I +S++ G++ FT+
Sbjct: 3333 DVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVD 3392
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYS 3432
P G ++V K LDRE+ S YSL ++A DSG P + + I ++DVNDN P F NY+
Sbjct: 3393 PVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYT 3452
Query: 3433 TTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRR 3492
+QEN P+G+ +LQL+++D DS NGPP+SF I GN F + P G L +A
Sbjct: 3453 AVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHT 3512
Query: 3493 AQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGK 3552
Y L +QA DSG P S T +RV V E+S + P+A+PLEIFI ED+F GG++GK
Sbjct: 3513 ESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGK 3572
Query: 3553 IHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTT 3612
IHATD+D D LT++L E+ F V + DGKIIA GL G Y NV+VSDG F
Sbjct: 3573 IHATDQDMYDVLTFALKSEQK--SLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVP 3630
Query: 3613 AGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHK-LDIKRANIHLASL 3671
V V+V + E LQ + + F ++PE+ V H +R L + L K+ ++ + S+
Sbjct: 3631 IDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISI 3690
Query: 3672 QPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMPMVPCQGPT 3731
QP +D+L E HS FY+ L ++++ + +E+ + + SA+ C G
Sbjct: 3691 QPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLENIMRI---SAILEKNCSGLD 3747
Query: 3732 CQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNG------------------ 3773
CQ Q C + LD TYSTAR+S + PR + C+CNG
Sbjct: 3748 CQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGLCPGSNDPCVEKPCPGD 3807
Query: 3774 ----------------------------TATRFSGQSYVRYRA---PAARNWHIHFYLKT 3802
T+ F+G SY++YR ++ + L+T
Sbjct: 3808 MQCVSYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRT 3867
Query: 3803 LQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGNLS-SQRHVNDHEWHSILVEEMD 3861
LQ I+++T + LK+ G + C G G L S R VND WHS+ +E
Sbjct: 3868 LQSNGIIMYTRANPCIILKIVDGKLWFQLDC-GSGPGILGISGRAVNDGSWHSVFLELNR 3926
Query: 3862 ASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHS--------SSNVSQGFEGCL 3913
L +D P + L E + G L+ + + V GF+GCL
Sbjct: 3927 NFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTRVTQVLSGFQGCL 3986
Query: 3914 DAVVVNEEALDLLAPGKTVAGLLE-TQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVC 3972
D+V++N L L + A ++ T+ C L+ D C ++ C +GG C+ GY C
Sbjct: 3987 DSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQC 4046
Query: 3973 KCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGH 4032
C QF+G++CE C PC GG+C CNC TG CE + C
Sbjct: 4047 TCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREE 4106
Query: 4033 C------------------------------LVTPEIQRGD--WGQQELLIITVAVAFII 4060
C +V P IQ G G++EL+ I V V F+I
Sbjct: 4107 CENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAV-VLFVI 4165
Query: 4061 ISTVGLLFYCRRCKSHKPVA------MEDP---DLLARSVGVDTQAM------------- 4098
V L R+ K + ++DP LL +S G+ + +
Sbjct: 4166 FILVVLFIVFRKKVFRKNYSRNNITLVQDPATAALLNKSNGIPFRNLRGSGDGRNVYQEV 4225
Query: 4099 --PAIELNPLSASSC------NNLNQPEPSKASVPNELVTFGPNS------KQRPVVCSV 4144
P + + P++ + C +NL++ E+ TF P S ++ VVCSV
Sbjct: 4226 GPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEHQEMTTFHPESPRILTARRGVVVCSV 4285
Query: 4145 PPRLPPAAVPSHSDNEPVIKRTW------------------------------------- 4167
P L PA P SD + + K W
Sbjct: 4286 APNL-PAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQS 4344
Query: 4168 -SSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGG- 4225
S ++ Y W P ++ E P+ E G SAH+ ST + E + GG
Sbjct: 4345 DSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDG---GSAHQGSTREL--ESDYYLGGY 4399
Query: 4226 -----FPFP-----LEMENKRAPLPPRYSNQNLEDLMPSRPPSPRERLVAPC 4267
+P P L + PLP + +Q E L PS+P S L C
Sbjct: 4400 DIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQ-YEALPPSQPVSLASTLSPDC 4450
Score = 392 bits (1008), Expect = e-108
Identities = 450/1751 (25%), Positives = 721/1751 (41%), Gaps = 170/1751 (9%)
Query: 29 SAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYV 88
S HFT S Y+ +I EN++ T V +G L EP ++Y I++ K+ V
Sbjct: 1978 SGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEP---LKYSILNPGNKFKIKSTSGV 2034
Query: 89 VGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPL 147
+ + +RE ++ Y L+++A+ + L VV V+I D ND P+
Sbjct: 2035 I-----------QTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPV 2083
Query: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAG 207
F Y + D + I +VTA D D G N E Y F I+P SG V +
Sbjct: 2084 FVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKE 2143
Query: 208 KLNVTWRG-KHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDS 266
N ++ + +LA D K S +V P KP ASV
Sbjct: 2144 AFNSDLSNIEYGVTILAKDG-GKPSLSTSVELPITIVNKAMPVFDKPFYTASV------- 2195
Query: 267 NDGTTYATVLVDANSSGAEVESV--EVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWME 324
N+ T ++ N++ E + + ++ GDP K F +F +K ++ ++
Sbjct: 2196 NEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNI--------DFDTGVLKVVSPLD 2247
Query: 325 Y--LHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVV 382
Y + L+++A + + F++ Y LSE S G+ V+
Sbjct: 2248 YEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVL 2307
Query: 383 MVRVTPA------FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT- 435
V A + Q V + F +++ +GLI T +++D H L +R+
Sbjct: 2308 QVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSI 2367
Query: 436 ---SPGQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENG 491
P +S V+V I I D N++ P+FN+ Y+ + E P G V V A+D D +
Sbjct: 2368 DSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFD 2427
Query: 492 YVTYSI-AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSI 550
+ YSI +G F +D G+I+ S + M+ +Y+ V SD F +V I
Sbjct: 2428 RLEYSILSGNDRTSFLMDSKSGVITLSNHRK-QRMEPLYSLNVSVSD--GLFTSTAQVHI 2484
Query: 551 FLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIVSGNELE 608
++ N P F + +R++ G ++ + A D D + Y I++ +
Sbjct: 2485 --RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKD 2542
Query: 609 YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPV 668
F ++ VI+ +R ++ S+ + A DG + T+ + VV +
Sbjct: 2543 RFLIDSNGQVITTER--LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDE------- 2593
Query: 669 TCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESV 728
N PQF V V
Sbjct: 2594 ---------------------------------------NDNAPQFMT-VEYRASVRADV 2613
Query: 729 PINTPLARLAATDPDAGFNGKLVYVI---ADGNEEGCFDIELETGLLTVAAPLDYEATNF 785
+ ++ A DPD G N ++ Y + A + +I+ + G + +
Sbjct: 2614 GRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
Query: 786 YILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAEL--- 842
V D G P K S + ++V P F Y TI+EDT +G+T+ L
Sbjct: 2674 LSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRIL 2733
Query: 843 -------TTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEA 895
+T + + +N + F + TG + + LDRE+ P + KV A
Sbjct: 2734 PSQNVWFSTVNGERPENNKGGI--------FVIEQETGTIKLDKRLDRETSPAFHFKVAA 2785
Query: 896 RDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLG 955
K +F+V D+ I + D+NDN P T + E +P GT LT + A D D G
Sbjct: 2786 TIPLDKVDIVFTV-DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG 2844
Query: 956 PAGEVRYVLMDGAH-----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLAR 1010
G+V Y L + F +D TG + ++LD E + S+ ASD G +
Sbjct: 2845 ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSL 2904
Query: 1011 RTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGELQY 1069
+ V V V D+N+N P FA V++G V+E+ P G V V++ D D S ++ ++ Y
Sbjct: 2905 SSTALVSVRVTDINDN--APVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSY 2962
Query: 1070 FLRAGT--GLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
+ G G A + Q + PLDRE Y+L + A D G ++ EV V
Sbjct: 2963 HITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD-GLFVTQAMVEV--SV 3019
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMI 1187
+D NDN P Q + + ED P +L++ A D D S G + +++ FF +
Sbjct: 3020 SDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-L 3078
Query: 1188 HPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLF 1247
P +G L T LDRE + L D G +S ++ + DVNDNPP+FS +
Sbjct: 3079 DPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI--LEDVNDNPPVFSSDHY 3136
Query: 1248 NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF- 1306
N + E + + + R+ A D D G+N +V YS+ DS FSID +G++
Sbjct: 3137 NTCVYE--NTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLD 3194
Query: 1307 --TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVME-TDP 1363
YNI +++ATD Q P + L I + P F+ Y TV E T P
Sbjct: 3195 REQQSSYNI-SVRATD--QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP 3251
Query: 1364 VNHMVGVISVE---GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTV 1420
++ V + G + I G++ F I TG I ++ LD + L V
Sbjct: 3252 GTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 1421 EVTDGSRTIATQVHIFMI--ANINHHRPQFLETRYEVRVPQDTVPG--VELLRVQAID-Q 1475
E DG + V I ++N + P+F + Y + +D + G V LL + +D Q
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQ 3371
Query: 1476 DKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK 1535
G+ ++G +D + F +DP G++ KLD S ++L V D IP
Sbjct: 3372 PNGQIHFSIVNGDRD----NEFTVDPVLGLVKVKKKLD-RERVSGYSLLVQAVDSGIPAM 3426
Query: 1536 RNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNA-EVHYSL 1594
+ V I + D N + P FT +Y A + + GT +LQ+ D D N +S+
Sbjct: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
Query: 1595 LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSD 1654
L GN E F ++ GI+ A + L V+A+D G PQ + + V
Sbjct: 3487 LSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEES 3545
Query: 1655 RSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP---SEVTYELREGNKDGVFSMNSYSGL 1711
P E F+ E G I + A +T+ L+ K +F +NS+ G
Sbjct: 3546 THKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQK-SLFKVNSHDGK 3604
Query: 1712 ISTQKKLDHEK 1722
I LD K
Sbjct: 3605 IIALGGLDSGK 3615
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 1095 bits (2832), Expect = 0.0
Identities = 989/3525 (28%), Positives = 1608/3525 (45%), Gaps = 259/3525 (7%)
Query: 71 YRIISGDVANVFKTEEYV--VGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEK-TLE 127
YRII G+ A F+ + + G FL + +K L+REV Y L+++ +K +
Sbjct: 174 YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGG----LDREVTPQYQLLVEVEDKGEPK 229
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+V V + D ND P+F Y+ + ED + S + +V A DAD G NA+ Y
Sbjct: 230 RRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL 289
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
F + P +G++TV L+ R ++ L V A+DR G + L V+
Sbjct: 290 QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDN 349
Query: 248 PAL---RKPPAIASVVVTPPDSNDGTTYATVLV-DANSSGAEVE-SVEVVGGDPGKHFKA 302
+ R PA + ++ GT A + V DA+S A SV+++GG+ +HF+
Sbjct: 350 DPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV 409
Query: 303 IKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARS--GSGPYFYSQIRGFHLPPSKLSSL 360
S + SL+ V E + +NL++ G+ P Q R S ++SL
Sbjct: 410 QSS--KVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQAR------SSVASL 461
Query: 361 K------------FEKAVYRVQLSEFSPPGSRVVMVRVTPAFP----NLQYVLKPSSENV 404
F + VYRV LSE +PPGS V + T NL+Y + +
Sbjct: 462 VIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLG 521
Query: 405 GFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-------PGQASTVVVIDIVDCNNHAPL 457
F ++ +GL+TT Q+ + S P + +V+ ++D N+ P+
Sbjct: 522 WFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPV 581
Query: 458 FNR-SSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI--AGPKALPFSIDPYLGII 514
F++ YD ++ EN P GT +L + ATD D G+NG V +S+ A F +DP G +
Sbjct: 582 FSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRL 641
Query: 515 STSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIR 574
ST +D E + Y+ V A+D GSP + I + L ++NDN P+F V I+
Sbjct: 642 STISSLDRE-EQAFYSLLVLATDLGSP-PQSSMARINVSLLDINDNSPVFYPVQYFAHIK 699
Query: 575 QDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ 632
++ P G I T+SA D D N +KY I +G+ F +N SGVIS + + L +
Sbjct: 700 ENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSR-FQVNAQSGVISTR---MALDREE 755
Query: 633 PTSYSLKITASDGKNYASPTTLNITV-VKDPHFEVPV----------------------- 668
T+Y L+I A+DG N SP +T+ V D PV
Sbjct: 756 KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSV 815
Query: 669 ----------------TCDKTGV--LTQFTKTILHFIGLQNQESS--------------D 696
T D+ G+ + Q T + + +E S
Sbjct: 816 SASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTG 875
Query: 697 EEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIAD 756
+ +++ +N +P F +S++V+E+ + + A DPD G NG ++Y +
Sbjct: 876 DTMVNITVKDLNDNSPHFLQAI-ESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ 934
Query: 757 GNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDN 816
N + F I + G +++ PLD A ++ I + D+G PQ SS +LTV V D NDN
Sbjct: 935 -NPKNLFAINEKNGTISLLGPLDVHAGSYQI-EILASDMGVPQLSSSVILTVYVHDVNDN 992
Query: 817 APRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPT--EKFSLHPLTGE 874
+P F Y++T+SE V + ++ D DS NG + YT+ + F + P G+
Sbjct: 993 SPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQ 1051
Query: 875 LVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKV 934
L + LDRE + RY+L V A D+ + L + ++ + LEDVNDN P + +
Sbjct: 1052 LYIKSELDRELQDRYVLMVVASDRAVE--PLSATVNVTVILEDVNDNRPLFNSTNYTFYF 1109
Query: 935 PEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFE---R 991
E+ G+ + + A D D GP GEVRY + F + ++G + + D E R
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSF-EMVQPDFELHAISGEITNTHQFDRESLMR 1168
Query: 992 RAG---YNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSG 1048
R G ++ ++ A+D G P + V V + D+N+N P F +Q + E++ +
Sbjct: 1169 RRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNA--PKFLKDFYQATISESAANL 1226
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
TQV+ V+A D D G +G + Y + G F+I+ +G + + LD E Y L +
Sbjct: 1227 TQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQ 1286
Query: 1109 AVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSS 1168
AVD G++PL+S + I++ D NDN P ++ + + E+ +G V + A D DS
Sbjct: 1287 AVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGD 1346
Query: 1169 KGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRV 1228
L ++IT N G F I P TG + A++LD E + + L +T D G P ST V
Sbjct: 1347 NADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSV 1406
Query: 1229 VVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDE 1288
V+ + D NDNPP F + E + P+ V + A D D +NG+++Y+I
Sbjct: 1407 VIHVRDFNDNPPSFPPGDIFKSIVENI-PIGTS-VISVTAHDPDADINGQLSYTIIQQMP 1464
Query: 1289 EA--FSIDLVTGVVSSSSTFTAGEYNI--LTIKATDSGQPPLSASVRL-HIEWIPWPRPS 1343
F+ID V G + +++ N+ LT+KA D P + L ++ +
Sbjct: 1465 RGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLND 1524
Query: 1344 SIPLAFDETYYSFTVMETDPVNHMVGVISV-------EGRPGLFWFNISGGDKDMDFDIE 1396
++P+ + S + DP + V++ EG G + I GD D F ++
Sbjct: 1525 NVPM-----FISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD-TFIVD 1578
Query: 1397 KTTGSIVIARPLDTRRRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYE 1454
+ +G + +A L + YNL V TD R +T ++ ++ P F + +Y
Sbjct: 1579 RYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLD--GPVFTQPKYI 1635
Query: 1455 VRVPQDTVPGVELLRVQAIDQDKGKSLI--YTIH-GSQDPGSASLFQLDPSSGVLVTVGK 1511
+ + G ++ ++A ++ + Y + ++ LF + +G++ T
Sbjct: 1636 TILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI 1695
Query: 1512 LDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAP 1570
LD G + + V ++ R V I ++D N +PP F + +V + I
Sbjct: 1696 LDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGD 1755
Query: 1571 GTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTV 1630
G++++Q+ AMDAD G NA V Y+++ G ++ F I+ G + ++LD+ + ++L V
Sbjct: 1756 GSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLV 1814
Query: 1631 KAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP--- 1687
+A+D Q D+ + I V + P FS+ Y +IPE GS + + A
Sbjct: 1815 RADD--GLQSSDM-RINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSG 1871
Query: 1688 --SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVV 1745
E+TY + E ++DG+F +N +G+ + + LD+E Y L +R + G FT + V
Sbjct: 1872 VNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVY 1931
Query: 1746 VDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKIL 1805
+I+D NDN P+F +++ + E P+ S ++ V + +D+D NS L Y I
Sbjct: 1932 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVL-------VFNVTDADDGINSQLTYSIA 1984
Query: 1806 EPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGS-PVLFAPRPAQVIIHVRD 1864
++L F +D + G L ++ +D ES + V VHD P AQV I + D
Sbjct: 1985 SGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLD 2043
Query: 1865 VNDSPPRF-SEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK------TGNADEAVT 1917
VND+PP F S ++ + PI + +A+D DS N I+ GN T
Sbjct: 2044 VNDNPPTFLSPKLTYIPENTPI--DTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGT 2101
Query: 1918 IH---PVTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYW 1974
I +TG + + L+ T + L T +V + + + D + F Q +Y
Sbjct: 2102 IDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVV-VMVLDINDNNPIFAQALYK 2160
Query: 1975 AAVKEN-LQDRKALVILGAQGNH-LNDTLSYFLLNG-TDMFHMVQSAGVLQTRGVAFDRE 2031
+ EN L + + A G+ N + Y ++NG T+ + S T DRE
Sbjct: 2161 VEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDRE 2220
Query: 2032 QQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQD--GTEPGDVL 2089
+ T+ L V+ D + R V + + D+ND P F+ PY + + GT P +L
Sbjct: 2221 KTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTIL 2280
Query: 2090 FQVSATDEDLGTNGAVTYEF--AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARD 2147
QV A D+D G+N ++Y + F + G++ + + D + ++ L + A D
Sbjct: 2281 -QVVARDDDRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATD 2338
Query: 2148 GGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLR-LI 2204
G+P+L + V V N + P F S Y +PE+ T +L A + + +
Sbjct: 2339 SGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAV 2398
Query: 2205 YNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGS--FSEATVEVLV 2262
I+ FT + TG + + LD E+K + V +D S +V V V
Sbjct: 2399 IRIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTV 2456
Query: 2263 EDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFF 2322
DVNDNPP F Y T I + V + +D D G N ++ Y + S+ F
Sbjct: 2457 TDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEK---F 2513
Query: 2323 QINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQP 2382
I+ G + L+ ++ F V V+ D G P T T V V + D P+ R
Sbjct: 2514 HIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKADF-PKVRAK 2570
Query: 2383 QYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLC 2442
+ E L V I S + Y I SGN F I+ +G +S+
Sbjct: 2571 EQTFMFPENQPVSSL---VTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPL 2627
Query: 2443 KKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTK 2499
Y + + A DG F + + I + N +P F++ + +E+ EN + K
Sbjct: 2628 DFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN-LSPRK 2686
Query: 2500 VIDLLAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVM 2558
++ + A+DKDSGP G +DY I+N FSIN G+I +++ LDRE + V+ IK
Sbjct: 2687 ILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSS 2746
Query: 2559 ARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNA 2618
+ + V I + DENDN P+F + ++ + N V +V D D G NA
Sbjct: 2747 DKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINA 2805
Query: 2619 DVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVR 2678
YS+ L INP TG + + L + + A D G W V
Sbjct: 2806 ISRYSIMDASL---PFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVT 2859
Query: 2679 LQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDG 2738
+ V + P+FS Y PE GS+ V V A DP S + ++
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSK---VTQVFATDPDEGSNGQVFYFIKSQSE 2916
Query: 2739 VFSLDPDTGVIKVRKPMDHES-TKLYQIDVMAHCLQNT-------DVVSLVSVNIQVGDV 2790
F ++ TG I ++ + +++ T +++ H T ++S +V I + D
Sbjct: 2917 YFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDS 2976
Query: 2791 NDNRPVFEADPYKAVLTENMPVGTSVIQVTAI-DKDTGRDGQVSYRLSADPGSNVHELFA 2849
NDN P F Y +T+N+ VGT +I+VTAI DKD G + +V Y +S D N F
Sbjct: 2977 NDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISND---NHLGKFK 3033
Query: 2850 IDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASE 2909
+D+++GWI+ L + Q + V A D G LSSQA V +++T+EN + P F+
Sbjct: 3034 LDNDTGWISVASSLISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEFSQS 3092
Query: 2910 EYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSR 2969
++ E+ G +V T+ D D + N + I+ G+ G F I+ ++
Sbjct: 3093 HMSATIPESHSIGSIVRTVSARDRD-AAMNGLIKYSISSGNEEGIFAIN--SSTGILTLA 3149
Query: 2970 KTLDREHTAKYLLRVTASDGKFQASV---TVEIFVLDVNDNSPQCSQLLYTGKVHEDVFP 3026
K LD E K+ + ++A DG + A +V + V+DVNDNSP Y V E+
Sbjct: 3150 KALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPS 3209
Query: 3027 GHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAK 3086
G ++ ++ATD D+ TNA I Y++ + F +DP+TG +TT LD E K ++L K
Sbjct: 3210 GTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVK 3269
Query: 3087 A--TDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA 3144
A R A + + ++ N+ PRF + + T V VFA D D G
Sbjct: 3270 AFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGT 3329
Query: 3145 NAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGT 3203
+ +V Y + +S + F I+ TG I + L + + L V A + G+ I + +
Sbjct: 3330 DGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGS-IRGADIDE 3388
Query: 3204 VTVSVVGLE-DYLPVFLNTEHSVQVPEDAPPGTEVLQLATL---TRPGAEKTGYRVVSGN 3259
VTV+V L+ + P+F +SVQ+ E P GT V ++ + P + Y + SGN
Sbjct: 3389 VTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGN 3448
Query: 3260 EQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP 3319
E G F ++ +TG + V A LD ET P Y LS+ + S + +++V + D+N++ P
Sbjct: 3449 ENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP 3508
Query: 3320 QFPQDPYSTRVLENALVGDVILTVSATDEDGPLN-SDITYSLIGGNQLGHFTIHPKKGEL 3378
V+EN G +++T+ +TD D P N TY L+ + G L
Sbjct: 3509 MLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVL 3566
Query: 3379 QVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423
+ +DREQ + + L + DSG P + + I V D NDNP
Sbjct: 3567 STTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 1070 bits (2766), Expect = 0.0
Identities = 937/3282 (28%), Positives = 1500/3282 (45%), Gaps = 257/3282 (7%)
Query: 393 LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS----PGQASTVVV-ID 447
L L PS E L ++ GL D YQL + P + + V +
Sbjct: 187 LDITLNPSGEGAFLHLVSKGGL-------DREVTPQYQLLVEVEDKGEPKRRGYLQVNVT 239
Query: 448 IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSI 507
+ D N++ P+F S Y + E+ G+SVL V A D D G N + Y + + PF +
Sbjct: 240 VQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD-EGTPFQM 298
Query: 508 DPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPM---- 563
DP G+I+ +P+D+E +R Y+ V+A D G P + ++ +QL ++NDN P+
Sbjct: 299 DPETGLITVREPLDFEA-RRQYSLTVQAMDRGVPSLTGRAEAL-IQLLDVNDNDPVVKFR 356
Query: 564 -FEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ---NLKYEIVSGNELEYFDLNHFSGV- 618
F + S+ ++ VG + ++ D D N+ +I+ GNE +F++
Sbjct: 357 YFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPN 416
Query: 619 ISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQ 678
+SL + L + SY+L ++ SD NY +P G Q
Sbjct: 417 LSLIKVASALDRERIPSYNLTVSVSD--NYGAPP---------------------GAAVQ 453
Query: 679 FTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLA 738
++ + N + S Y++N + E P + ++ ++
Sbjct: 454 ARSSVASLVIFVNDINDHPPVFSQQVYRVN---------------LSEEAPPGSYVSGIS 498
Query: 739 ATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAP--LDYEATNFYILNVTVYDLG 796
ATD D+G N L Y I GN G F I +GL+T + LD E + +LN++ D G
Sbjct: 499 ATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQG 558
Query: 797 TPQKSSWKLLTVNVKDWNDNAPRFP-PGGYQLTISEDTEVGTTIAELTTKDADSEDNGRV 855
K S+ L V + D ND P F P GY +++ E+ GT + L D D DNG V
Sbjct: 559 VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV 618
Query: 856 RYTLL---SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI 912
R++L + F L P++G L LDRE + Y L V A D S S+ +
Sbjct: 619 RFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQS--SMARIN 676
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTF 972
++L D+NDNSP + E+ P G+ +T + A+DPDLG G V+Y + G F
Sbjct: 677 VSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRF 736
Query: 973 RVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHF 1032
+V+ +G + LD E + Y L + A+DGG L V + VLD +N PP F
Sbjct: 737 QVNAQSGVISTRMALDREEKTAYQLQIVATDGGN-LQSPNQAIVTITVLDTQDN--PPVF 793
Query: 1033 ASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTL 1092
+ + V EN G V V+A D L+ + Y + G F+INQ TG + T
Sbjct: 794 SQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTTA 851
Query: 1093 APLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPV 1152
+DRE S+Y L V+A G+V + T V I V D NDN P QA+ ++ E+
Sbjct: 852 NVIDREEQSFYQLKVVA-SGGTV--TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQA 908
Query: 1153 GTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEV 1212
G S+ Q A DPD G + +++ N F I+ G +S LD + + +E+
Sbjct: 909 GHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD-VHAGSYQIEI 966
Query: 1213 TVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272
D G P L S+ + V + DVNDN P+F + V L E PV+ +++ ASD D
Sbjct: 967 LASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSES-EPVN-SRFFKVQASDKD 1024
Query: 1273 EGLNGRVTYSI-EDSDEEAFSI--DLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSAS 1329
G NG + Y+I E + +AF I D + S Y +L + A+D PLSA+
Sbjct: 1025 SGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRY-VLMVVASDRAVEPLSAT 1083
Query: 1330 VRLHI--EWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGG 1387
V + + E + RP F+ T Y+F E VG +S + F +G
Sbjct: 1084 VNVTVILEDVNDNRP-----LFNSTNYTFYFEEEQRAGSFVGKVSAVDKD----FGPNGE 1134
Query: 1388 DK------DMDFDIEKTTGSIVIARPLDT----RRRSN--YNLTVEVTDGS-----RTIA 1430
+ DF++ +G I D RRR ++ TV TD + A
Sbjct: 1135 VRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQA 1194
Query: 1431 TQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQD 1490
T VH++M +IN + P+FL+ Y+ + + ++LRV A D D+G + + IH S
Sbjct: 1195 T-VHVYM-KDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGL--IHYSII 1250
Query: 1491 PGSASL-FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGN 1549
G+ F +D +SG + +GKLD + P+ + V IP+ + I + D N
Sbjct: 1251 KGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCT-LNIDILDEN 1309
Query: 1550 LHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALL 1609
+ P F + V + + G + V A D+D G NA+++YS+ N+ G F+I+
Sbjct: 1310 DNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNT 1369
Query: 1610 GIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669
G I LA+KLD + + L + A+DQG P +V+IHV + + P F + F I
Sbjct: 1370 GSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSI 1429
Query: 1670 PESIPVGSPILLVSAMSPS-----EVTYEL-REGNKDGVFSMNSYSGLISTQKKLDHEKI 1723
E+IP+G+ ++ V+A P +++Y + ++ + F+++ G I T ++D E
Sbjct: 1430 VENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFA 1489
Query: 1724 SSYQLKIRGSNMA-----GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIM 1778
+ ++L ++ ++ A + V + + D NDN PMF+ + +A + S++
Sbjct: 1490 NLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAA-DPSAVIGSVLT 1548
Query: 1779 DKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQF 1838
I A+D D+ AN + Y+I+ + F +D G L + S + S +
Sbjct: 1549 -------TIMAADPDEGANGEIEYEIINGDTDTFI-VDRYSGDLRVASAL-VPSQLIYNL 1599
Query: 1839 CVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASD 1898
V D G + +I+ D P F++ Y + G ++ + A+
Sbjct: 1600 IVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIGTNVISIEAAS 1655
Query: 1899 ---EDSEVNYSIKTGNADEAV-----TIHPVTGSISVL------NPAFLGLSRKLTIRAS 1944
++ V Y I + +E TI TG I A L L I S
Sbjct: 1656 PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKS 1715
Query: 1945 DGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG--NHLNDTL 2001
+ A V+I+L + D F D+ V+EN+ D ++ L A N +
Sbjct: 1716 TAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALV 1775
Query: 2002 SYFLLNGTDMFHMV--QSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVS 2059
+Y +++G D + +S ++ TR + DRE++ + L V D + + ++
Sbjct: 1776 TYTIISGADDSFRIDPESGDLIATRRL--DRERRSKYSLLVRADDGLQSSDMR---INIT 1830
Query: 2060 IEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT--YFR 2117
+ DVND+ PKF Y I + T PG ++ + ATD+D G NG +TY ED F
Sbjct: 1831 VSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFF 1890
Query: 2118 IDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYK 2177
++P G +L + DY+ Y L V A DGG + N + P+F Y
Sbjct: 1891 LNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYS 1950
Query: 2178 VRVPENITLYTPILH---TQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYE 2234
+ EN+ + + +L T A +L Y+I + L FT D K GVL V LD E
Sbjct: 1951 TSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRE 2009
Query: 2235 SKTKHVFTVRATDT----ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTP 2290
S++ + V+ D A S A V +++ DVNDNPPTF T I E P T
Sbjct: 2010 SQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTV 2068
Query: 2291 VIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVR 2350
V + A+D DSG N + Y ++ + + F I GE+ ELD E ++ + V
Sbjct: 2069 VFKAQATDPDSGPNSYIEYTLL---NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVV 2125
Query: 2351 AMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD 2410
A DKG P L+ T VVV V DINDN P F Q Y+ ++E G +++V A D D
Sbjct: 2126 ATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGT 2185
Query: 2411 TSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVP---- 2466
++ Y I++GN ++ F I+S +G I++ + +Y+L V A+D R + P
Sbjct: 2186 NGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD---RGSTPRTDT 2242
Query: 2467 --VYINTTNANKYSPEFQQHLYEAELAENAMVGT---KVIDLLAIDKDSGPYGTIDYTII 2521
V I + N + P F+ Y + EN +GT ++ ++A D D G + Y +
Sbjct: 2243 STVSIVLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLSYVLF 2300
Query: 2522 NKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDN 2581
F+++ +G++ Q LDRE V+ I T+ +I+ D NDN
Sbjct: 2301 GGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDN 2360
Query: 2582 PPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTG 2641
P F + Y +I + + V+ V A DAD +NA + INP TG
Sbjct: 2361 VPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQFT-----INPSTG 2415
Query: 2642 VVKVKDSLVGLE---NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTF 2698
+ + +L+ E N TL + + G P +S V + V + P+F Y
Sbjct: 2416 QI-ITSALLDRETKDNYTL-VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVT 2473
Query: 2699 SAPEDLPEGSEIGIVKAVAAQ----DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKP 2754
P GS + V A + YSL G E F +DP G I P
Sbjct: 2474 HIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEK-----FHIDPLRGAIMAAGP 2527
Query: 2755 MDHESTKLYQIDVM-AHCLQNTDVVSLVSVNIQVGDVND-NRPVFEADPYKAVLTENMPV 2812
++ S + + V TD S + V VN + P A + EN PV
Sbjct: 2528 LNGASEVTFSVHVKDGGSFPKTD-----STTVTVRFVNKADFPKVRAKEQTFMFPENQPV 2582
Query: 2813 GTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYH 2872
+ V +T + R +SY +++ N+ F ID +G ++ Q LD E Q Y
Sbjct: 2583 SSLVTTITG---SSLRGEPMSYYIAS---GNLGNTFQIDQLTGQVSISQPLDFEKIQKYV 2636
Query: 2873 FHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD 2932
+ A D G SS + +++ D NDNAP F + + ++EN P +++ T+ +D
Sbjct: 2637 VWIEARDGGFP-PFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMD 2694
Query: 2933 ADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG--- 2989
D S N Q+ I G+ F I+ E I S + LDRE + Y+L + +SD
Sbjct: 2695 KD-SGPNGQLDYEIVNGNMENSFSINHATGE--IRSVRPLDREKVSHYVLTIKSSDKGSP 2751
Query: 2990 KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS 3049
SV V I +LD NDN+P+ SQ+ ++ V E+ G+ + +V+ +D D NA YS
Sbjct: 2752 SQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYS 2810
Query: 3050 LHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDN 3109
+ F ++P TG++ L+RE D + + A D G + D+T+ V D+NDN
Sbjct: 2811 IMDASL-PFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW-TVSTDVTIFVTDINDN 2868
Query: 3110 APRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVI 3169
APRF + + + T + + V VFA DPD+G+N QV Y + +E +F I+ATTG I
Sbjct: 2869 APRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE-YFRINATTGEI 2927
Query: 3170 RLEKPLQVRPQAPLE--------LTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNT 3221
++ L+ + V +SD G P +S TVT+++V D P FL +
Sbjct: 2928 FNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISET-TVTINIVDSNDNAPQFLKS 2986
Query: 3222 EHSVQVPEDAPPGTEVLQLATLTRPGA---EKTGYRVVSGNEQGRFRLDARTGILYVNAS 3278
++ V ++ GT+++++ + + Y + + N G+F+LD TG + V +S
Sbjct: 2987 KYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASS 3046
Query: 3279 LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGD 3338
L + + +F+++ K + LS TV + +T+ N H P+F Q S + E+ +G
Sbjct: 3047 LISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGS 3106
Query: 3339 VILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRA 3398
++ TVSA D D +N I YS+ GN+ G F I+ G L +AKALD E + + + A
Sbjct: 3107 IVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISA 3166
Query: 3399 TDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPEN 3458
D G + + V DVNDN P F +Y TV EN+P G+ V+ L +D DS N
Sbjct: 3167 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTN 3226
Query: 3459 GPPYSFRITKGNNGSAFRVTPDGWLVTAEG-LSRRAQEWYQLQIQASDSGIPPLSSLTSV 3517
+ ++ F + P+ ++T +G L ++ Y L ++A + S +V
Sbjct: 3227 A--VIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATV 3284
Query: 3518 RVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRD 3559
+ + + Y P + + + E +G +VG++ A+DRD
Sbjct: 3285 NIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRD 3326
Score = 1047 bits (2708), Expect = 0.0
Identities = 958/3348 (28%), Positives = 1547/3348 (46%), Gaps = 268/3348 (8%)
Query: 370 QLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAH- 428
Q+ E PPG+ V ++ P F + S + F +N+ TG + TT +D
Sbjct: 50 QVLEEQPPGTLVGTIQTRPGF-----TYRLSESHALFAINSSTGALYTTSTIDRESLPSD 104
Query: 429 -YQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH 487
L + +S T V + + D N++AP+F S T E+ G V+ TATD D
Sbjct: 105 VINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDI 164
Query: 488 GENG--YVTYSI-----AGPKALPFSIDP-----YLGIISTSKPMDYELMKRIYTFRVRA 535
G NG + +Y I AG L +++P +L ++S +D E+ + Y V
Sbjct: 165 GSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKG-GLDREVTPQ-YQLLVEV 222
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + ++++NDN P+F + + +D VG S++ ++A D DE
Sbjct: 223 EDKGEP-KRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGT 281
Query: 596 NLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLN 655
N +E F ++ +G+I+++ P L YSL + A D
Sbjct: 282 NADIRYRLQDEGTPFQMDPETGLITVREP---LDFEARRQYSLTVQAMDR---------- 328
Query: 656 ITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFE 715
G+ + E L N +F
Sbjct: 329 --------------------------------GVPSLTGRAEALIQLLDVNDNDPVVKFR 356
Query: 716 DHFPQS---IDVLESVPINTPLARLAATDPDA-GFNGKLVYVIADGNEEGCFDIEL---- 767
+FP + V E+ + T +A L TD D+ NG + I GNE+ F+++
Sbjct: 357 -YFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVP 415
Query: 768 ETGLLTVAAPLDYEATNFYILNVTVYD-LGTP------QKSSWKLLTVNVKDWNDNAPRF 820
L+ VA+ LD E Y L V+V D G P +SS L + V D ND+ P F
Sbjct: 416 NLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVF 475
Query: 821 PPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVT-- 878
Y++ +SE+ G+ ++ ++ D DS N +RY+++S H +VT
Sbjct: 476 SQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTG 535
Query: 879 --GHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQ-CITEHNRLKVP 935
G LDRE + +L + ARDQ H S L++TL DVND P E + V
Sbjct: 536 SSGGLDRELASQIVLNISARDQGV--HPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVV 593
Query: 936 EDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGA--HGTFRVDLMTGALILERELDFERRA 993
E+ P GT L L A+D DLG G VR+ L + +FR+D ++G L LD E +A
Sbjct: 594 ENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQA 653
Query: 994 GYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV 1053
Y+L + A+D G P + ++ + V +LD+N+N P F + ++EN P G+ +
Sbjct: 654 FYSLLVLATDLGSP-PQSSMARINVSLLDINDN--SPVFYPVQYFAHIKENEPGGSYITT 710
Query: 1054 VAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG 1113
V+A D D G +G ++Y + AG + F +N +G+I T LDRE + Y L ++A D G
Sbjct: 711 VSATDPDLGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769
Query: 1114 SVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLT 1173
++ + V I V D DNPP SQ + + E+ +G V + A D +S ++
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNS--NIS 827
Query: 1174 FNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGIL 1233
+ IT+G+ G F I+ VTG L+TA +DRE + + L+V V G ++ + V + +
Sbjct: 828 YLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKV-VASGG--TVTGDTMVNITVK 884
Query: 1234 DVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSI 1293
D+NDN P F + +V + E + +++ A D DEG+NG V YS++ + + F+I
Sbjct: 885 DLNDNSPHFLQAIESVNVVENWQ--AGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAI 942
Query: 1294 DLVTGVVSSSSTFT--AGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDE 1351
+ G +S AG Y I I A+D G P LS+SV L + S + FD+
Sbjct: 943 NEKNGTISLLGPLDVHAGSYQI-EILASDMGVPQLSSSVILTVYVHDVNDNSPV---FDQ 998
Query: 1352 TYYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARP 1407
Y T+ E++PVN + G G + I+ G+ F I G + I
Sbjct: 999 LSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGI-FPDGQLYIKSE 1057
Query: 1408 LDTRRRSNYNLTVEVTDGS-RTIATQVHIFMI-ANINHHRPQFLETRYEVRVPQDTVPGV 1465
LD + Y L V +D + ++ V++ +I ++N +RP F T Y ++ G
Sbjct: 1058 LDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGS 1117
Query: 1466 ELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGS-----GP 1518
+ +V A+D+D G + + Y+ Q F+L SG + + D S G
Sbjct: 1118 FVGKVSAVDKDFGPNGEVRYSFEMVQPD-----FELHAISGEITNTHQFDRESLMRRRGT 1172
Query: 1519 SQHTLTVMVRDQEIPIK-RNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ + TV+ DQ IP ++ V ++++D N + P+F + Y+A++ ++ A T++L+V
Sbjct: 1173 AVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV 1232
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGS 1637
A D D G N +HYS++KGN E F I++ G +TL KLD ++L ++A D G+
Sbjct: 1233 SASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGT 1292
Query: 1638 PQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTY 1692
+ T+ I + + + P F KS FV++ E++ +G + V+A +++ Y
Sbjct: 1293 IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYY 1352
Query: 1693 ELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIID 1750
+ N G FS++ +G I KKLD E S Y+L I + + + VV+ + D
Sbjct: 1353 SITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412
Query: 1751 ENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE--PE 1808
NDN P F I E P+ + ++ + A D D + N L Y I++ P
Sbjct: 1413 FNDNPPSFPPGDIFKSIVENIPIGTSVIS-------VTAHDPDADINGQLSYTIIQQMPR 1465
Query: 1809 ALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPV---LFAPRPAQVIIHVRDV 1865
F ID GT+ +E+D E F+ V +DQ P+ +A + V I V D+
Sbjct: 1466 G-NHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALK--NVTILVTDL 1522
Query: 1866 NDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPV 1921
ND+ P F Q A + G L + A+D D E+ Y I G+ D + +
Sbjct: 1523 NDNVPMFISQNALAADPSAV-IGSVLTTIMAADPDEGANGEIEYEIINGDTDTFI-VDRY 1580
Query: 1922 TGSISVLNPAFLG-LSRKLTIRASD-GLYQDTALVKIS-LTQVLDKSLQFDQDVYWAAVK 1978
+G + V + L L + A+D G + + +++ + Q LD + F Q Y +K
Sbjct: 1581 SGDLRVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPV-FTQPKYITILK 1639
Query: 1979 ENLQ-DRKALVILGAQGNHLNDTLSYFLLNGT-------DMFHMVQSAGVLQTRGVAFDR 2030
E + I A + Y++++ +F + + G++QT + DR
Sbjct: 1640 EGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI-LDR 1698
Query: 2031 EQQDTHEL--AVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088
EQ L + + R + V ++++D+NDNPP F +++ G
Sbjct: 1699 EQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSK 1758
Query: 2089 LFQVSATDEDLGTNGAVTYEF---AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIA 2145
+ Q++A D D G N VTY A+D FRIDP GD+ + D + +KY L V A
Sbjct: 1759 IMQLTAMDADEGANALVTYTIISGADD--SFRIDPESGDLIATRRLDRERRSKYSLLVRA 1816
Query: 2146 RDGGTPSLQSEE---EVLVTVRNKSNPLFQSPYYKVRVPENI---TLYTPILHTQARSPE 2199
DG LQS + + V+ N P F P Y +PE+ +L IL T S
Sbjct: 1817 DDG----LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGV 1872
Query: 2200 GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVE 2259
+ Y + E++ +F + TGV +T LDYE + ++ TVRA D G F+ V
Sbjct: 1873 NGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG-GQFTTIRVY 1931
Query: 2260 VLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS 2319
+ DVNDNPP FS Y+TS+ E LP + V+ +D D G N ++Y I G +
Sbjct: 1932 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIA-SGDSLG 1990
Query: 2320 KFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPP---LTGETLVVVNVSDINDNP 2376
+F G + ++ LD E+Q +++ V+ D P T V + + D+NDNP
Sbjct: 1991 QF--TVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNP 2048
Query: 2377 PEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILS--GNQDRHFFINSSSG 2434
P F P+ + E +V K QA DPDS S +EY +L+ GN+ F I + G
Sbjct: 2049 PTFLSPKL-TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK---FSIGTIDG 2104
Query: 2435 IISMFNLCKKHLDSSYNLRVGASD---GVFRATVPVYINTTNANKYSPEFQQHLYEAELA 2491
+ + + S+Y L V A+D ++ V + + N +P F Q LY+ E+
Sbjct: 2105 EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEIN 2164
Query: 2492 ENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTE 2550
EN + GT +I + A D D G G + Y I+N +++F I+ G I + LDRE +
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPT 2224
Query: 2551 RVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNV-SKDSPVIQVLA 2609
+ ++ R R TV I+L D ND P F+ S Y+V++ N+ + ++QV+A
Sbjct: 2225 YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVA 2284
Query: 2610 YDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
D D G N+ ++Y + + +D +G + V SL + I A D G P
Sbjct: 2285 RDDDRGSNSKLSYVLFGGN--EDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSP 2342
Query: 2670 HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA--VAAQDPVIYSLV 2727
+ + V ++P F+ Y + PED P G+++ +V A A + ++
Sbjct: 2343 ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII 2402
Query: 2728 RGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTD-VVSLVSVNIQ 2786
G + F+++P TG I +D E+ Y + V+ + + + S SV +
Sbjct: 2403 GGNSQ-------FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVT 2455
Query: 2787 VGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHE 2846
V DVNDN P F+ PY + G+ V VT D D G + ++ Y LS G N E
Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLS---GRN-SE 2511
Query: 2847 LFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRF 2906
F ID G I L+ + T+ HV G + + V V ++ D P+
Sbjct: 2512 KFHIDPLRGAIMAAGPLNGASEVTFSVHV---KDGGSFPKTDSTTVTVRFVNKAD-FPKV 2567
Query: 2907 ASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRI 2966
++E EN LV T+ S + ++ YI G+ F I Q+ + +
Sbjct: 2568 RAKEQTFMFPENQPVSSLVTTI----TGSSLRGEPMSYYIASGNLGNTFQIDQLTGQ--V 2621
Query: 2967 SSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHED 3023
S + LD E KY++ + A DG F + ++I VLDVNDN+P + + ++ E+
Sbjct: 2622 SISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN 2681
Query: 3024 VFPGHFILKVSATDLDTDTNAQITYSL-HGPGAHEFKLDPHTGELTTLTALDRERKDVFN 3082
+ P IL VSA D D+ N Q+ Y + +G + F ++ TGE+ ++ LDRE+ +
Sbjct: 2682 LSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYV 2740
Query: 3083 LVAKATDGG--GRSCQADITLHVEDVNDNAPRF---FPSHCAVAVFDNTTVKTPVAVVFA 3137
L K++D G +S + +++ D NDNAPRF F +H V +N+ + V V
Sbjct: 2741 LTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAH----VPENSPLGYTVTRVTT 2796
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP 3197
D D G NA YS+ D A F+I+ +TG I + +PL + V A D G +
Sbjct: 2797 SDEDIGINAISRYSIMD-ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVS 2855
Query: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG---YR 3254
VT+ V + D P F T + + PE G++V Q+ T P G Y
Sbjct: 2856 TD----VTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFA-TDPDEGSNGQVFYF 2910
Query: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETSP--------KYFLSIECSRKSSSSLSDVTT 3306
+ S +E FR++A TG ++ L ++ ++ + S + SL TT
Sbjct: 2911 IKSQSEY--FRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT 2968
Query: 3307 VMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDE-DGPLNSDITYSLIGGNQ 3365
V +NI D N++ PQF + Y T V +N VG ++ V+A D+ D LNS++ Y + N
Sbjct: 2969 VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNH 3028
Query: 3366 LGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPR 3425
LG F + G + VA +L + ++ + + A D G PPL + I V + N + P
Sbjct: 3029 LGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPE 3088
Query: 3426 FFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRV-TPDGWLV 3484
F Q + S T+ E+ IGS V + D D+ NG + I+ GN F + + G L
Sbjct: 3089 FSQSHMSATIPESHSIGSIVRTVSARDRDAAMNG-LIKYSISSGNEEGIFAINSSTGILT 3147
Query: 3485 TAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDE 3544
A+ L + +++ I A D G + SV V+V + + +P L + F TV E+
Sbjct: 3148 LAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENA 3207
Query: 3545 FQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQG 3592
G V ++ATD D + + + F + P+ +I QG
Sbjct: 3208 PSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVID-PNTGVITTQG 3254
Score = 989 bits (2557), Expect = 0.0
Identities = 987/3667 (26%), Positives = 1603/3667 (43%), Gaps = 306/3667 (8%)
Query: 104 TALLNREV--RDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDM 161
T+ ++RE D L++ ++ T T V V + D ND P+F PS VT ED
Sbjct: 93 TSTIDRESLPSDVINLVVLSSAPTYP----TEVRVLVRDLNDNAPVFPDPSIVVTFKEDS 148
Query: 162 PLKSPICKVTATDADLGQNAEFYYAFN----TRSEMFAIHPTSGVVTVAGKLNVTWRGKH 217
+ TATD+D+G N + ++ + F + T L++ +G
Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGL 208
Query: 218 ELQVLAVDRMRKISEGNGFGSLAALV---VHVEPALRKPPAIASVVVTPPDSNDGTTYAT 274
+ +V ++ E G + V V+ PP S D ++
Sbjct: 209 DREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSS 268
Query: 275 VLVDANSSGAEVESVEVVGG--DPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLS 332
VL A + E + ++ D G F+ E L++V++ E ++L+
Sbjct: 269 VLQVAAADADEGTNADIRYRLQDEGTPFQM------DPETGLITVREPLDFEARRQYSLT 322
Query: 333 LQARSGSGPYFYSQIRGFHL-----PPSKLSSLKFEKAVYR-VQLSEFSPPGSRVVMVRV 386
+QA P + + ++ A R + E + G+ V ++ V
Sbjct: 323 VQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 387 TPAFP-----NLQYVLKPSSENVGFKLNA----RTGLITTTKLMDFHDRAHYQLHIRTS- 436
T A N+ + +E F++ + LI +D Y L + S
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD 442
Query: 437 -----PGQA----STV--VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDR 485
PG A S+V +VI + D N+H P+F++ Y L E PPG+ V ++ATD
Sbjct: 443 NYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDG 502
Query: 486 DHGENGYVTYSIAGPKALP-FSIDPYLGIIST--SKPMDYELMKRIYTFRVRASDWGSPF 542
D G N + YSI L F I + G+++T S +D EL +I + A D G
Sbjct: 503 DSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQI-VLNISARDQGV-H 560
Query: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTG-SIRQDWPVGKSIMTMSAIDVDELQN--LKY 599
+ + + L ++ND +P+F + S+ ++ P G ++ + A D D N +++
Sbjct: 561 PKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRF 620
Query: 600 EIVSGN-ELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITV 658
+ + F L+ SG +S +L + YSL + A+D
Sbjct: 621 SLQEAETDRRSFRLDPVSGRLST---ISSLDREEQAFYSLLVLATD-------------- 663
Query: 659 VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHF 718
L + S ++S IN +P F +
Sbjct: 664 ------------------------------LGSPPQSSMARINVSLLDINDNSPVF---Y 690
Query: 719 PQSI--DVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAA 776
P + E+ P + + ++ATDPD G NG + Y I+ G+ F + ++G+++
Sbjct: 691 PVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSR-FQVNAQSGVISTRM 749
Query: 777 PLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVG 836
LD E Y L + D G Q + ++T+ V D DN P F Y + E+ +G
Sbjct: 750 ALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALG 809
Query: 837 TTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLDRESEPRYILKVE 894
+ ++ D N + Y + + +K F+++ +TG+L +DRE + Y LKV
Sbjct: 810 YHVGSVSASTMDLNSN--ISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVV 867
Query: 895 ARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDL 954
A G + T + IT++D+NDNSP + + V E+ G + A DPD
Sbjct: 868 A-----SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE 922
Query: 955 GPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLC 1014
G G V Y L F ++ G + L LD Y + + ASD G P ++
Sbjct: 923 GVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVI 981
Query: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
+ V V DVN+N P F ++ + E+ P ++ V A D DSG +GE+ Y + G
Sbjct: 982 -LTVYVHDVNDN--SPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038
Query: 1075 TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNP 1134
AF I D G + + LDRE Y L V+A DR PLS+ V + + D NDN
Sbjct: 1039 NTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNR 1097
Query: 1135 PQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLL 1194
P + + +E+ G+ V ++ A D D G++ ++ F +H ++G +
Sbjct: 1098 PLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM--VQPDFELHAISGEI 1155
Query: 1195 STAQQLDREN----KDEHILEVTVL--DNGEPS-LKSTSRVVVGILDVNDNPPIFSHKLF 1247
+ Q DRE+ + + TV+ D G P LK + V V + D+NDN P F +
Sbjct: 1156 TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFY 1215
Query: 1248 NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVS--SSS 1304
+ E + ++ V R+ ASD+DEG NG + YSI + ++E F+ID +G V+
Sbjct: 1216 QATISESAANLTQ--VLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKL 1273
Query: 1305 TFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPV 1364
+ A L I+A DSG PL+++ L+I+ + + P +F ++ V+E +
Sbjct: 1274 DYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILD--ENDNTP-SFPKSTLFVDVLENMRI 1330
Query: 1365 NHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTV 1420
+V ++ G +++I+G + F I TGSI +A+ LD +S Y L +
Sbjct: 1331 GELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNI 1390
Query: 1421 EVTDGSRT--IATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDK- 1477
D R +T + + + N + P F + ++ G ++ V A D D
Sbjct: 1391 TAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450
Query: 1478 -GKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK- 1535
L YTI G+ F +D G + T ++D + LTV DQ +PI+
Sbjct: 1451 INGQLSYTIIQQMPRGNH--FTIDEVKGTIYTNAEIDREFA-NLFELTVKANDQAVPIET 1507
Query: 1536 RNFVW--VTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYS 1593
R + VTI V D N + P F + A+ P + G+ L + A D D G N E+ Y
Sbjct: 1508 RRYALKNVTILVTDLNDNVPMFISQNALAADPSAVI-GSVLTTIMAADPDEGANGEIEYE 1566
Query: 1594 LLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPS 1653
++ G+++ F ++ G + +A L + + L V A D G + + I +
Sbjct: 1567 IINGDTDTFI-VDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQGL 1624
Query: 1654 DRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP--SE-------VTYELREGNKDGVFS 1704
D P+F++ +Y + E P+G+ ++ + A SP SE V+ E +F+
Sbjct: 1625 D--GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFT 1682
Query: 1705 MNSYSGLISTQKKLDHEKISS-YQLKIRGSNMAGAFTDVM---VVVDIIDENDNAPMFLK 1760
+ ++G+I T LD E+ + Y + + + AF V + + D NDN P+F
Sbjct: 1683 IGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPT 1742
Query: 1761 STFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMG 1820
+ E S IM + A D+D+ AN+L+ Y I+ A F+IDP G
Sbjct: 1743 DMLDLTVEENIGDGSKIMQ-------LTAMDADEGANALVTYTIISG-ADDSFRIDPESG 1794
Query: 1821 TLTIVSEMDYESMPSFQFCVYVHD--QGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
L +D E + V D Q S + ++ I V DVND P+FS +Y
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDGLQSSDM-------RINITVSDVNDHTPKFSRPVYS 1847
Query: 1879 VAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLG 1934
I PG + + A+D+DS VN Y + + D ++P+TG ++
Sbjct: 1848 FDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYE 1907
Query: 1935 LSRK--LTIRASDGLYQDTAL-VKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILG 1991
+ + LT+RA DG Q T + V ++ V D F + Y ++ ENL +++
Sbjct: 1908 VQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN 1967
Query: 1992 AQG--NHLNDTLSYFLLNGTDMFHM-VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTP 2048
+ +N L+Y + +G + V GVL+ A DRE Q + L V+V D P
Sbjct: 1968 VTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLK-ALDRESQSFYNLVVQVHD--LP 2024
Query: 2049 QRVAQGL-----VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNG 2103
Q A V + + DVNDNPP F P T I + T V+F+ ATD D G N
Sbjct: 2025 QIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNS 2083
Query: 2104 AVTYEFAEDY-TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVT 2162
+ Y F I G++ L D + ++ Y L V+A D G PSL S EV+V
Sbjct: 2084 YIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVM 2143
Query: 2163 VR--NKSNPLFQSPYYKVRVPENITLYTPILHT-QARSPEGL--RLIYNIVEEEPLMLFT 2217
V N +NP+F YKV + EN T I+ A EG ++ Y IV F
Sbjct: 2144 VLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFR 2203
Query: 2218 TDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSE-ATVEVLVEDVNDNPPTFSQLV 2276
D TG +TV PLD E + TV+ATD ++ +TV +++ D+ND P F
Sbjct: 2204 IDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSP 2263
Query: 2277 YTTSISEGLPA-QTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQ 2335
Y+ ++ E L ++Q++A D D G N +SY + G + F ++ S GE+ Q
Sbjct: 2264 YSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLF--GGNEDNAFTLSAS-GELGVTQ 2320
Query: 2336 ELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
LD E ++ F + + A D G P LTG + V V D+NDN P F Y + E A G
Sbjct: 2321 SLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTG 2380
Query: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVG 2455
VL V A D D+ + + I+ GN F IN S+G I L + +Y L V
Sbjct: 2381 TDVLLVNASDADASKNAVIR--IIGGNSQ--FTINPSTGQIITSALLDRETKDNYTLVVV 2436
Query: 2456 ASDG----VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG 2511
SD ++ V + T+ N P FQ H Y + + G+ V + D D G
Sbjct: 2437 CSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG 2496
Query: 2512 PYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGG--RVAF 2568
P + Y++ + SEKF I+P G I L+ + + V +DGG +
Sbjct: 2497 PNSELHYSLSGR-NSEKFHIDPLRGAIMAAGPLNGASE----VTFSVHVKDGGSFPKTDS 2551
Query: 2569 CTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPED 2628
TV + ++ D P + +A E T N S V + + ++Y + +
Sbjct: 2552 TTVTVRFVNKADFP-KVRAKEQTFMFPENQPVSSLVTTITGSSL---RGEPMSYYIASGN 2607
Query: 2629 LVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL 2688
L + +I+ +TG V + L + Q +I+A+DGG P ++S + + V+ +
Sbjct: 2608 L-GNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNA 2666
Query: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP---VIYSLVRGTTPESNKDGVFSLDPD 2745
P F E + E+L + + P + Y +V G N + FS++
Sbjct: 2667 PIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNG-----NMENSFSINHA 2721
Query: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAV 2805
TG I+ +P+D E Y + + + + + V V I + D NDN P F + + A
Sbjct: 2722 TGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAH 2780
Query: 2806 LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDC 2865
+ EN P+G +V +VT D+D G + Y + + F I+ +G I + L+
Sbjct: 2781 VPENSPLGYTVTRVTTSDEDIGINAISRYSIM-----DASLPFTINPSTGDIVISRPLNR 2835
Query: 2866 ETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELV 2925
E Y V A+D G T+ V + +TD NDNAPRF+ Y E +E G V
Sbjct: 2836 EDTDRYRIRVSAHDSGWTVSTD----VTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKV 2891
Query: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTA------- 2978
+ D D N QV +I F I+ E I +++ L ++
Sbjct: 2892 TQVFATDPD-EGSNGQVFYFIKSQSEY--FRINATTGE--IFNKQILKYQNVTGFSNVNI 2946
Query: 2979 -KYLLRVTASD-GK--FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVS 3034
++ VT+SD GK + TV I ++D NDN+PQ + Y V ++V G +++V+
Sbjct: 2947 NRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVT 3006
Query: 3035 ATD-LDTDTNAQITYSLHGPG-AHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGG 3092
A D D N+++ Y + +FKLD TG ++ ++L + F + A D G
Sbjct: 3007 AIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGN 3066
Query: 3093 RSCQADITLHVEDVNDN--APRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVY 3150
+ T+H+ +N P F SH + + ++ ++ + V V ARD D N + Y
Sbjct: 3067 PPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKY 3126
Query: 3151 SLPD-SAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVV 3209
S+ + EG F+I+++TG++ L K L E+T+ A D G + + +VTV+V+
Sbjct: 3127 SISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW-VARTGYCSVTVNVI 3185
Query: 3210 GLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL-ATLTRPGAEKTGYRVVSGNEQGRFRLDA 3268
+ D PVFL+ ++ V E+AP GT V+ L AT G V ++ F +D
Sbjct: 3186 DVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDP 3245
Query: 3269 RTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYST 3328
TG++ LDFET Y L+++ TV + + NE+ P+F Y
Sbjct: 3246 NTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYF 3305
Query: 3329 RVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQ 3388
+ E A G ++ V A+D D + ++ Y + G ++ F I+ K G++ V+ LDRE+
Sbjct: 3306 EISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK 3365
Query: 3389 ASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN-YSTTVQENSPIGSKVLQ 3447
SLK+ A + G + ++ + V ++ N P F LN YS + E PIG+ V
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTF 3425
Query: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDS 3506
+ D DS + +S+ I GN AF + P G + L R Y L + A DS
Sbjct: 3426 VSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDS 3485
Query: 3507 GIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ-----GGMVGKIHATDRD-- 3559
G P + S+ V + + + P +TV E E G +V + +TD D
Sbjct: 3486 GTPSATGSASLLVTLEDINDNGP-------MLTVSEGEVMENKRPGTLVMTLQSTDPDLP 3538
Query: 3560 -PQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPR----GHYSFNVTVSDGT--FTTT 3612
Q TY L +FS+ G + + + R Y VT G ++T
Sbjct: 3539 PNQGPFTYYLLSTGPATSYFSLSTA-GVLSTTREIDREQIADFYLSVVTKDSGVPQMSST 3597
Query: 3613 AGVHVYV 3619
VH+ V
Sbjct: 3598 GTVHITV 3604
Score = 933 bits (2411), Expect = 0.0
Identities = 859/3014 (28%), Positives = 1346/3014 (44%), Gaps = 225/3014 (7%)
Query: 720 QSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLD 779
Q VLE P T L T P GF +L F I TG L + +D
Sbjct: 47 QVFQVLEEQPPGT-LVGTIQTRP--GFTYRL------SESHALFAINSSTGALYTTSTID 97
Query: 780 YEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI 839
E+ ++N+ V + ++L V+D NDNAP FP +T ED+ G +
Sbjct: 98 RESLPSDVINLVVLSSAPTYPTEVRVL---VRDLNDNAPVFPDPSIVVTFKEDSSSGRQV 154
Query: 840 AELTTKDADSEDNG--RVRYTLLSPTE------KFSLHPLTGE-----LVVTGHLDRESE 886
T D+D NG Y ++ E +L+P +GE LV G LDRE
Sbjct: 155 ILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNP-SGEGAFLHLVSKGGLDREVT 213
Query: 887 PRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF 946
P+Y L VE D+ + + +T++D+NDN P + H + VPED G+ +
Sbjct: 214 PQYQLLVEVEDKGEPKRR--GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQ 271
Query: 947 LDASDPDLGPAGEVRYVLMDGAHGT-FRVDLMTGALILERELDFERRAGYNLSLWASDGG 1005
+ A+D D G ++RY L D GT F++D TG + + LDFE R Y+L++ A D G
Sbjct: 272 VAAADADEGTNADIRYRLQD--EGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRG 329
Query: 1006 RP-LARRTLCHVEVIVLDVNEN---LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061
P L R ++ +LDVN+N + +F + V EN+ GT V ++ D DS
Sbjct: 330 VPSLTGRAEALIQ--LLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS 387
Query: 1062 -GLDGELQYFLRAGTGLAAFSINQ----DTGMIQTLAPLDREFASYYWLTVLAVDRGSVP 1116
+G + + G F + + +I+ + LDRE Y LTV D P
Sbjct: 388 PAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAP 447
Query: 1117 -------LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
SSV + I V D ND+PP SQ V+ ++ E+AP G+ V + A D DS
Sbjct: 448 PGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLN 507
Query: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQ--LDRENKDEHILEVTVLDNGEPSLKSTSR 1227
L ++I SGN +G+F I +GL++T LDRE + +L ++ D G S ++
Sbjct: 508 ANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQ 567
Query: 1228 VVVGILDVNDNPPIFSH-KLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE-- 1284
+VV +LDVND P+FS + ++V + E +P + L A+D D G NG V +S++
Sbjct: 568 LVVTLLDVNDEKPVFSQPEGYDVSVVEN-APTGT-ELLMLRATDGDLGDNGTVRFSLQEA 625
Query: 1285 DSDEEAFSIDLVTGVVSSSSTFTAGE--YNILTIKATDSGQPPLSASVRLHIEWIPWPRP 1342
++D +F +D V+G +S+ S+ E + L + ATD G PP S+ R+++ +
Sbjct: 626 ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDN 685
Query: 1343 SSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMDFDIEKT 1398
S + F Y + E +P + +S G G ++IS GD+ F +
Sbjct: 686 SPV---FYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSR-FQVNAQ 741
Query: 1399 TGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIA--NINHHRPQFLETRYEVR 1456
+G I LD ++ Y L + TDG + I I + + P F + Y
Sbjct: 742 SGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Query: 1457 VPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGS 1516
V ++ G + V A D ++ Y I G +F ++ +G L T +D
Sbjct: 802 VFENVALGYHVGSVSASTMDLNSNISYLITTGDQKG---MFAINQVTGQLTTANVID-RE 857
Query: 1517 GPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQ 1576
S + L V+ + V I V+D N + P F Q +V + G + Q
Sbjct: 858 EQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQ 914
Query: 1577 VRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQG 1636
+A+D D GVN V YS LK N + F IN G I+L LD + + + + A D G
Sbjct: 915 AKAVDPDEGVNGMVLYS-LKQNPKNLFAINEKNGTISLLGPLD-VHAGSYQIEILASDMG 972
Query: 1637 SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAM-----SPSEVT 1691
PQ + ++V+ + ++P+F + Y V + ES PV S V A + E+
Sbjct: 973 VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIA 1032
Query: 1692 YELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA----GAFTDVMVVVD 1747
Y + EGN F + G + + +LD E Y L + S+ A A +V V+++
Sbjct: 1033 YTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILE 1091
Query: 1748 IIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY--KIL 1805
D NDN P+F + + E S + + A D D N + Y +++
Sbjct: 1092 --DVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-------VSAVDKDFGPNGEVRYSFEMV 1142
Query: 1806 EPEALKFFKIDPSMGTLTIVSEMDYESM------PSFQFCVYVHDQGSPVLFAPRPAQVI 1859
+P+ F++ G +T + D ES+ F F V DQG P P Q
Sbjct: 1143 QPD----FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP---QPLKDQAT 1195
Query: 1860 IHV--RDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSE----VNYSIKTGNAD 1913
+HV +D+ND+ P+F + Y+ I ++L V ASD D ++YSI GN +
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEE 1255
Query: 1914 EAVTIHPVTGSISVL-------NPAFLGLSRKLTIRASDG---LYQDTALVKISLTQVLD 1963
I +G ++++ PA+ L I+A D T + I + D
Sbjct: 1256 RQFAIDSTSGQVTLIGKLDYEATPAY-----SLVIQAVDSGTIPLNSTCTLNIDILDEND 1310
Query: 1964 KSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLS-YFLLNGTD---MFHMVQSAG 2019
+ F + + V EN++ + + + A + D Y+ + GT+ F + + G
Sbjct: 1311 NTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTG 1370
Query: 2020 VLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTII 2079
+ D E Q ++L + +D P R + V + + D NDNPP F + I
Sbjct: 1371 SI-FLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSI 1429
Query: 2080 QDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY---TYFRIDPYLGDISLKKPFDYQAL 2136
+ G + V+A D D NG ++Y + +F ID G I D +
Sbjct: 1430 VENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFA 1489
Query: 2137 NKYHLKVIARDGGTP-----SLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENI--TLYTP 2189
N + L V A D P +LVT N + P+F S P + ++ T
Sbjct: 1490 NLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLTT 1549
Query: 2190 ILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTA 2249
I+ + Y I+ + F D +G L V L S+ + V ATD
Sbjct: 1550 IMAADPDEGANGEIEYEIINGD-TDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLG 1607
Query: 2250 LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSY 2309
++T E+ + + P F+Q Y T + EG P T VI + A+ G V Y
Sbjct: 1608 -PERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA-SPRGSEAPVEY 1665
Query: 2310 QIVE---DGSDVSKFFQINGSTGEMSTVQELDYEAQQHFH-VKVRAMDKGDP-PLTGETL 2364
IV + V + F I TG + T LD E + V V A++K P T
Sbjct: 1666 YIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAE 1725
Query: 2365 VVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQD 2424
V + + DINDNPP F + V E G ++++ A+D D + + Y I+SG D
Sbjct: 1726 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADD 1785
Query: 2425 RHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQH 2484
F I+ SG + + S Y+L V A DG+ + + + I ++ N ++P+F +
Sbjct: 1786 -SFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRP 1844
Query: 2485 LYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLD 2544
+Y ++ E+ + G+ V +LA D DSG G I Y + F +NP + L +L
Sbjct: 1845 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRL- 1903
Query: 2545 RENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPV 2604
+ ++ + V A DGGG+ V + D NDNPP F + Y+ S+ N+ S V
Sbjct: 1904 LDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTV 1963
Query: 2605 IQVLAYDADEGQNADVTYSV-NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA 2663
+ DAD+G N+ +TYS+ + + L + ++ N V V+K D E+Q+ +
Sbjct: 1964 LVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDR----ESQSFYNLVVQ 2019
Query: 2664 QDGGP----PHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ 2719
P + S V + ++ + P F P T+ PE+ P + +V A
Sbjct: 2020 VHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDT---VVFKAQAT 2075
Query: 2720 DP-------VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCL 2772
DP + Y+L+ P NK FS+ G +++ +D E Y + V+A
Sbjct: 2076 DPDSGPNSYIEYTLL---NPLGNK---FSIGTIDGEVRLTGELDREEVSNYTLTVVATDK 2129
Query: 2773 QNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQV 2832
+ S V + V D+NDN P+F YK + EN GT +IQV A D D G +GQV
Sbjct: 2130 GQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQV 2189
Query: 2833 SYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALV 2892
Y + N ++ F IDS +G IT + LD E TYH V A D G T + + + V
Sbjct: 2190 RYGI---VNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-TDTSTV 2245
Query: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDA--DISEQNRQVTCYITEGD 2950
+ + D ND P F Y +V EN G L T+ + A D N +++ + G+
Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLFGGN 2303
Query: 2951 PLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQA---SVTVEIFVLDVNDN 3007
F +S G+ + ++LDRE +++L +TA+D A + T+ + V DVNDN
Sbjct: 2304 EDNAFTLSASGE---LGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDN 2360
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
P + Y + ED G +L V+A+D D NA I G +F ++P TG++
Sbjct: 2361 VPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII---GGNSQFTINPSTGQI 2417
Query: 3068 TTLTALDRERKDVFNLVAKATDGGG---RSCQADITLHVEDVNDNAPRFFPSHCAVAVFD 3124
T LDRE KD + LV +D G S + + V DVNDN PRF +
Sbjct: 2418 ITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPS 2477
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLE 3184
T + V V D D G N+++ YSL F ID G I PL +
Sbjct: 2478 PTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFS 2537
Query: 3185 LTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLT 3244
+ V+ G P + TVTV V D+ P E + PE+ P + V + +
Sbjct: 2538 VHVKD---GGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITGSS 2593
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
G E Y + SGN F++D TG + ++ LDFE KY + IE S
Sbjct: 2594 LRG-EPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSY 2652
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGN 3364
+ + + DVN++ P F +DP+ + +LEN L ILTVSA D+D N + Y ++ GN
Sbjct: 2653 EKLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNGN 2711
Query: 3365 QLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPP 3424
F+I+ GE++ + LDRE+ S Y L ++++D G P + I + D NDN P
Sbjct: 2712 MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAP 2771
Query: 3425 RFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD-GWL 3483
RF Q+ +S V ENSP+G V ++ SD D N R + + F + P G +
Sbjct: 2772 RFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINA---ISRYSIMDASLPFTINPSTGDI 2827
Query: 3484 VTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGED 3543
V + L+R + Y++++ A DSG + T V + VT+ + AP ++ E
Sbjct: 2828 VISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPEL 2884
Query: 3544 EFQGGMVGKIHATDRD--PQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYS-- 3599
G V ++ ATD D + Y + + +F + A G+I Q L + +
Sbjct: 2885 TEIGSKVTQVFATDPDEGSNGQVFYFIKSQ---SEYFRINATTGEIFNKQILKYQNVTGF 2941
Query: 3600 FNVTVSDGTFTTTA 3613
NV ++ +F T+
Sbjct: 2942 SNVNINRHSFIVTS 2955
Score = 592 bits (1526), Expect = e-168
Identities = 592/2207 (26%), Positives = 985/2207 (44%), Gaps = 257/2207 (11%)
Query: 69 VRYRIISGDVANVFKTEEYVVGNFCF-LRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
+ Y II+GD T+ ++V + LR+ + + L+ Y LI+ AT+ E
Sbjct: 1563 IEYEIINGD------TDTFIVDRYSGDLRVASALVPSQLI-------YNLIVSATDLGPE 1609
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
T + IL D P+F+ P Y + E P+ + + + A + YY
Sbjct: 1610 RRKSTTELTIILQGLD-GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIV 1668
Query: 188 NTRSE------MFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAA 241
+ R E +F I +G++ A L+ + + L + + I + F
Sbjct: 1669 SVRCEEKTVGRLFTIGRHTGIIQTAAILD-----REQGACLYLVDVYAIEKSTAF----- 1718
Query: 242 LVVHVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDAN-SSGAEVESVEVVGGD 295
P ++ A V +T D ND T + V+ N G+++ + + D
Sbjct: 1719 ------PRTQR----AEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDAD 1768
Query: 296 PGKHFKAIKSY----ARSNEF-------SLVSVKDINWMEYLHGFNLSLQARSGSGPYFY 344
G + A+ +Y + F L++ + ++ E ++L ++A G
Sbjct: 1769 EGAN--ALVTYTIISGADDSFRIDPESGDLIATRRLD-RERRSKYSLLVRADDG----LQ 1821
Query: 345 SQIRGFHLPPSKLS--SLKFEKAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLK 398
S ++ S ++ + KF + VY + E + PGS V + T + Y++
Sbjct: 1822 SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVN 1881
Query: 399 PSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSP--GQASTV-VVIDIVDCNNHA 455
E+ F LN TG+ T+L+D+ + +Y L +R GQ +T+ V +I+D N++
Sbjct: 1882 EDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNP 1941
Query: 456 PLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKAL-PFSIDPYLGII 514
P+F+ +SY +L EN+P G++VL TD D G N +TYSIA +L F++D G++
Sbjct: 1942 PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVL 2000
Query: 515 STSKPMDYELMKRIYTFRVRASDW----GSPFRREKEVSIFLQLRNLNDNQPMFEEVNCT 570
K +D E + Y V+ D S F +VSI L ++NDN P F T
Sbjct: 2001 KVLKALDRE-SQSFYNLVVQVHDLPQIPASRFTSTAQVSII--LLDVNDNPPTFLSPKLT 2057
Query: 571 GSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNEL-EYFDLNHFSGVISLKRPFINLT 629
I ++ P+ + A D D N E N L F + G + L L
Sbjct: 2058 -YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTG---ELD 2113
Query: 630 AGQPTSYSLKITASD-GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIG 688
+ ++Y+L + A+D G+ S +T + +V D
Sbjct: 2114 REEVSNYTLTVVATDKGQPSLSSSTEVVVMVLD--------------------------- 2146
Query: 689 LQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNG 748
IN P F +++ E+ T + ++ A D D G NG
Sbjct: 2147 ------------------INDNNPIFAQAL-YKVEINENTLTGTDIIQVFAADGDEGTNG 2187
Query: 749 KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTV 808
++ Y I +GN F I+ TG +TVA PLD E T Y L V D G+ ++ +++
Sbjct: 2188 QVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247
Query: 809 NVKDWNDNAPRFPPGGYQLTISEDTEVGT---TIAELTTKDADSEDNGRVRYTLLSPTE- 864
+ D ND P F Y + + E+ +GT TI ++ +D D N ++ Y L E
Sbjct: 2248 VLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLSYVLFGGNED 2305
Query: 865 -KFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
F+L +GEL VT LDRE++ R++L + A D S L + + ++DVNDN P
Sbjct: 2306 NAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPA--LTGTGTINVIVDDVNDNVP 2362
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALIL 983
++ +PED P GT + ++ASD D +R + G + F ++ TG +I
Sbjct: 2363 TFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII---GGNSQFTINPSTGQIIT 2419
Query: 984 ERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQE 1043
LD E + Y L + SD G P + V V V DVN+N PP F + +
Sbjct: 2420 SALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN--PPRFQHHPYVTHIPS 2477
Query: 1044 NSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYY 1103
+ G+ V V D D G + EL Y L +G F I+ G I PL+ AS
Sbjct: 2478 PTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLNG--ASEV 2534
Query: 1104 WLTVLAVDRGSVPLSSVTEVYIEVTDANDNPP--QMSQAVFYPSIQEDAPVGTSVLQLDA 1161
+V D GS P + T V + + D P Q +P E+ PV + V +
Sbjct: 2535 TFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFP---ENQPVSSLVTTITG 2591
Query: 1162 WDPDSSSKGK-LTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEP 1220
SS +G+ +++ I SGN F I +TG +S +Q LD E ++++ + D G P
Sbjct: 2592 ----SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 2647
Query: 1221 SLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT 1280
S ++ + +LDVNDN PIF F + E L +SP + + A D D G NG++
Sbjct: 2648 PFSSYEKLDITVLDVNDNAPIFKEDPF---ISEILENLSPRKILTVSAMDKDSGPNGQLD 2704
Query: 1281 YSIEDSD-EEAFSIDLVTGVVSSSSTFTAGE--YNILTIKATDSGQPPLSASVRLHIEWI 1337
Y I + + E +FSI+ TG + S + + +LTIK++D G P S SV++ I +
Sbjct: 2705 YEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINIL 2764
Query: 1338 P----WPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDK 1389
PR S I +S V E P+ + V ++ G + ++I D
Sbjct: 2765 DENDNAPRFSQI--------FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DA 2814
Query: 1390 DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFL 1449
+ F I +TG IVI+RPL+ Y + V D T++T V IF + +IN + P+F
Sbjct: 2815 SLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIF-VTDINDNAPRFS 2873
Query: 1450 ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLV 1507
T Y + P+ T G ++ +V A D D+G + + Y I + F+++ ++G +
Sbjct: 2874 RTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE-----YFRINATTGEIF 2928
Query: 1508 T--VGKLDLGSGPS-----QHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHY 1560
+ K +G S +H+ V D+ P + VTI++ D N + P+F + Y
Sbjct: 2929 NKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKY 2988
Query: 1561 EASVPDTIAPGTELLQVRAM-DADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
V + GT+L++V A+ D D G+N+EV Y + N G F ++ G I++A L
Sbjct: 2989 FTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLI 3048
Query: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
+ +TV A+D+G+P ATV I V + P FS+S IPES +GS +
Sbjct: 3049 SDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIV 3108
Query: 1680 LLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSN 1734
VSA + Y + GN++G+F++NS +G+++ K LD+E +++ I S
Sbjct: 3109 RTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTI--SA 3166
Query: 1735 MAGAFTD----VMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHAS 1790
+ G + V V++ID NDN+P+FL + + E AP + ++ N A+
Sbjct: 3167 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLN-------AT 3219
Query: 1791 DSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL 1850
D+D N+++ Y + ++ F IDP+ G +T +D+E+ S+ V + P
Sbjct: 3220 DADSGTNAVIAYTVQSSDS-DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDE 3276
Query: 1851 FAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE----DSEVNYS 1906
A V I ++ N+ PRF ++Y I G + V ASD D EV+Y
Sbjct: 3277 ERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYL 3336
Query: 1907 IKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIR-------ASDGLYQDTALVKISLT 1959
I + + I+ TG I V +++++ + G D V +++
Sbjct: 3337 IFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVL 3396
Query: 1960 QVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDT---LSYFLLNGTD--MFHM 2014
D + F ++Y + E + + + A + + SYF+ +G + F +
Sbjct: 3397 DANDPPI-FTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSI 3455
Query: 2015 VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLP 2074
G + T DRE + L+V D+ TP + V++ED+NDN P
Sbjct: 3456 NPQTGQI-TVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML---- 3510
Query: 2075 YYTI----IQDGTEPGDVLFQVSATDEDLGTN-GAVTYEFAED---YTYFRIDPYLGDIS 2126
T+ + + PG ++ + +TD DL N G TY +YF + G +S
Sbjct: 3511 --TVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLS 3567
Query: 2127 LKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQS 2173
+ D + + ++L V+ +D G P + S V +TV ++++ QS
Sbjct: 3568 TTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQS 3614
Score = 572 bits (1473), Expect = e-162
Identities = 578/2129 (27%), Positives = 919/2129 (43%), Gaps = 176/2129 (8%)
Query: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92
FT Y + E T V S E +E V Y I+S + EE VG
Sbjct: 1629 FTQPKYITILKEGEPIGTNVISIEAASPRGSEAP--VEYYIVS------VRCEEKTVGRL 1680
Query: 93 CFLRIRTKSSNTA-LLNREVRDSYTLI-IQATEKTLELEALTRVVVHIL--DQNDLKPLF 148
+ T TA +L+RE L+ + A EK+ R V I D ND P+F
Sbjct: 1681 FTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVF 1740
Query: 149 SPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA-FNTRSEMFAIHPTSGVVTVAG 207
+T+ E++ S I ++TA DAD G NA Y + + F I P SG +
Sbjct: 1741 PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATR 1800
Query: 208 KLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSN 267
+L+ R K+ L V A D ++ S + V P +P + P D+
Sbjct: 1801 RLDRERRSKYSLLVRADDGLQ--SSDMRINITVSDVNDHTPKFSRPVYSFDI---PEDTI 1855
Query: 268 DGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLH 327
G+ A +L + SG E +V D + + F+L + D +Y
Sbjct: 1856 PGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPI--TGVFNLTRLLDYEVQQY-- 1911
Query: 328 GFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVT 387
+ L+++A G G + ++ F++ + F Y L E P GS V++ VT
Sbjct: 1912 -YILTVRAEDGGGQFTTIRVY-FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVT 1969
Query: 388 PAFPNLQYVLK---PSSENVGFKLNARTGLITTTKLMDFHDRAHYQL--------HIRTS 436
A + L S +++G + G++ K +D ++ Y L I S
Sbjct: 1970 DADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPAS 2029
Query: 437 PGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYS 496
++ V I ++D N++ P F S + EN P T V ATD D G N Y+ Y+
Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTF-LSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYT 2088
Query: 497 IAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRN 556
+ P FSI G + + +D E + YT V A+D G P + + + +
Sbjct: 2089 LLNPLGNKFSIGTIDGEVRLTGELDREEVSN-YTLTVVATDKGQP-SLSSSTEVVVMVLD 2146
Query: 557 LNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNH 614
+NDN P+F + I ++ G I+ + A D DE N ++Y IV+GN + F ++
Sbjct: 2147 INDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDS 2206
Query: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTG 674
+G I++ +P L + +Y L + A+D ++P T
Sbjct: 2207 VTGAITVAKP---LDREKTPTYHLTVQATD--RGSTPRT--------------------- 2240
Query: 675 VLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESV-PINTP 733
D S+ IN + P FE P S++V E++ +
Sbjct: 2241 ---------------------DTSTVSIVLLDINDFVPVFE-LSPYSVNVPENLGTLPRT 2278
Query: 734 LARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVY 793
+ ++ A D D G N KL YV+ GNE+ F + +G L V LD E ++L +T
Sbjct: 2279 ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITAT 2337
Query: 794 DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNG 853
D G+P + + V V D NDN P F Y TI ED GT + + DAD+ N
Sbjct: 2338 DSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA 2397
Query: 854 RVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
+R ++ +F+++P TG+++ + LDRE++ Y L V D S L S T +++
Sbjct: 2398 VIR--IIGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSP-EPLSSSTSVLV 2454
Query: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFR 973
T+ DVNDN P+ +P PG+ + + +D D+GP E+ Y L F
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFH 2514
Query: 974 VDLMTGALILERELDFERRAGYNLSLWASDGGR-PLARRTLCHVEVIVLDVNENLHPPHF 1032
+D + GA++ L+ + S+ DGG P T V + P
Sbjct: 2515 IDPLRGAIMAAGPLNGASEVTF--SVHVKDGGSFPKTDSTTVTVRFV-----NKADFPKV 2567
Query: 1033 ASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGE-LQYFLRAGTGLAAFSINQDTGMIQT 1091
+ EN P + V + S L GE + Y++ +G F I+Q TG +
Sbjct: 2568 RAKEQTFMFPENQPVSSLVTTITG----SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSI 2623
Query: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAP 1151
PLD E Y + + A D G P SS ++ I V D NDN P + F I E+
Sbjct: 2624 SQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLS 2683
Query: 1152 VGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILE 1211
+L + A D DS G+L + I +GN F I+ TG + + + LDRE ++L
Sbjct: 2684 -PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLT 2742
Query: 1212 VTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDL 1271
+ D G PS ++ +V++ ILD NDN P FS ++F+ +PE SP+ V R+ SD
Sbjct: 2743 IKSSDKGSPSQSTSVKVMINILDENDNAPRFS-QIFSAHVPEN-SPLG-YTVTRVTTSDE 2799
Query: 1272 DEGLNGRVTYSIEDSDEEAFSIDLVTG--VVSSSSTFTAGEYNILTIKATDSGQPPLSAS 1329
D G+N YSI D+ F+I+ TG V+S + + + A DSG +S
Sbjct: 2800 DIGINAISRYSIMDA-SLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW-TVSTD 2857
Query: 1330 VRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV----EGRPGLFWFNIS 1385
V + + I P F T Y E + V + EG G ++ I
Sbjct: 2858 VTIFVTDINDNAP-----RFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIK 2912
Query: 1386 GGDKDMDFDIEKTTGSIV---IARPLDTRRRSNYNL---TVEVTDGSR----TIATQVHI 1435
+ F I TTG I I + + SN N+ + VT R I+
Sbjct: 2913 --SQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVT 2970
Query: 1436 FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAI-DQDKG--KSLIYTIHGSQDPG 1492
I + N + PQFL+++Y V ++ G +L+RV AI D+D G + Y I G
Sbjct: 2971 INIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLG 3030
Query: 1493 SASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP 1552
F+LD +G + L + +TV +D+ P + V I V + N H
Sbjct: 3031 K---FKLDNDTGWISVASSL-ISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHT 3086
Query: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII 1612
P F+Q H A++P++ + G+ + V A D D +N + YS+ GN EG F IN+ GI+
Sbjct: 3087 PEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGIL 3146
Query: 1613 TLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPES 1672
TLA+ LD H +T+ A D G +V ++V + ++P+F +YF + E+
Sbjct: 3147 TLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLEN 3206
Query: 1673 IPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQ 1727
P G+ ++ ++A + Y ++ + D +F ++ +G+I+TQ LD E SY
Sbjct: 3207 APSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYH 3265
Query: 1728 LKIRGSNMAG--AFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPF 1785
L ++ N+ + V + + N+ P F+ + +ISEAAP +++ +
Sbjct: 3266 LTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE------ 3319
Query: 1786 VIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQ 1845
+ ASD D + + Y I K F+I+ G + + +D E V +
Sbjct: 3320 -VFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNF 3378
Query: 1846 GSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED----- 1900
GS V + V D ND PP F+ IY V I + G + V A D D
Sbjct: 3379 GSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSW 3437
Query: 1901 SEVNYSIKTGNADEAVTIHPVTGSISV---LNPAFLGLSRKLTIRASDGLYQDT--ALVK 1955
S +Y I +GN + A +I+P TG I+V L+ L + + G T A +
Sbjct: 3438 SRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLL 3497
Query: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHL---NDTLSYFLLN--GTD 2010
++L + D V V EN + ++ L + L +Y+LL+
Sbjct: 3498 VTLEDINDNGPML--TVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPAT 3555
Query: 2011 MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKF 2070
+ + +AGVL T DREQ L+V +D+ PQ + G V +++ D NDNP +
Sbjct: 3556 SYFSLSTAGVLSTTR-EIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQS 3614
Query: 2071 KHLPYYTIIQDGTEPGDVLFQVSATDEDL 2099
+ + + PG +L V D D+
Sbjct: 3615 RTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 110 bits (275), Expect = 3e-23
Identities = 144/605 (23%), Positives = 240/605 (39%), Gaps = 72/605 (11%)
Query: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92
F+ SH +ATI E+ S + V + A ++Y I SG+ +F
Sbjct: 3089 FSQSHMSATIPESHSIGSIVRTVSARDRDAAM-NGLIKYSISSGNEEGIFAI-------- 3139
Query: 93 CFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLEL--------EALTRVVVHILDQNDL 144
+S+T +L Y L Q E T+ V V+++D ND
Sbjct: 3140 --------NSSTGILTLAKALDYELC-QKHEMTISAIDGGWVARTGYCSVTVNVIDVNDN 3190
Query: 145 KPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTR-SEMFAIHPTSGVV 203
P+F Y T+ E+ P + + + ATDAD G NA Y + S++F I P +GV+
Sbjct: 3191 SPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVI 3250
Query: 204 TVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTP 263
T G L+ + + L V A + S A + + ++ P S +
Sbjct: 3251 TTQGFLDFETKQSYHLTVKAFN-----VPDEERCSFATVNIQLKGTNEYVPRFVSKLYYF 3305
Query: 264 PDSN---DGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDI 320
S GT V G + E ++ G+ K K + + + + V I
Sbjct: 3306 EISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRK-----KGFQINKKTGQIYVSGI 3360
Query: 321 NWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLK--------FEKAVYRVQLS 372
E +L + A++ + IRG + ++ F +Y VQ+S
Sbjct: 3361 LDREKEERVSLKVLAKN------FGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQIS 3414
Query: 373 EFSPPGSRVVMVRV-----TPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRA 427
E P G+ V V P++ Y + +EN F +N +TG IT T +D
Sbjct: 3415 EGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLP 3474
Query: 428 HYQLHI-----RTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
Y L + T S +++ + D N++ P+ S +G + EN PGT V+ + +
Sbjct: 3475 IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQS 3532
Query: 483 TDRDHGEN-GYVTYSI--AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWG 539
TD D N G TY + GP FS+ G++ST++ +D E + Y V D G
Sbjct: 3533 TDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFY-LSVVTKDSG 3590
Query: 540 SPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKY 599
P + ++ + + + NDN V + + G + ++ D D L +
Sbjct: 3591 VP-QMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHC 3649
Query: 600 EIVSG 604
+ SG
Sbjct: 3650 SLTSG 3654
Score = 65.9 bits (159), Expect = 9e-10
Identities = 33/99 (33%), Positives = 42/99 (42%), Gaps = 1/99 (1%)
Query: 3944 CCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCIL 4003
C + D C + C +GG C G G+ C CP F+G+ CE+ C +PC G C
Sbjct: 3859 CEIDIDECLPSPCHSGGTCHNLVG-GFSCSCPDGFTGRACERDINECLQSPCKNGAICQN 3917
Query: 4004 SPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRG 4042
P +C C YTG CE C C Q G
Sbjct: 3918 FPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSG 3956
Score = 62.8 bits (151), Expect = 7e-09
Identities = 32/106 (30%), Positives = 42/106 (39%), Gaps = 21/106 (19%)
Query: 3949 DYCSQNTCLNGGKCSWTHGAG---------------------YVCKCPPQFSGKHCEQGR 3987
D C C NGG C ++CKC P ++G CE
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 3988 ENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHC 4033
+ C +PC GGTC G SC+CP +TG CE + C + C
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPC 3909
Score = 57.4 bits (137), Expect = 3e-07
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 3951 CSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASC 4010
C Q+ C NG C G+ + C C ++GK CE C PC GG+C C
Sbjct: 3904 CLQSPCKNGAICQNFPGS-FNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962
Query: 4011 NCPHPYTGDRCEMEARGCSE 4030
+CP G CE+ + G E
Sbjct: 3963 HCPFGVFGKHCELNSYGFEE 3982
Score = 56.2 bits (134), Expect = 7e-07
Identities = 57/240 (23%), Positives = 100/240 (41%), Gaps = 38/240 (15%)
Query: 3771 CNGTATRFSGQSYVRYRAPAARNWHIHFYLKTLQPQAILLFT--NETAS----VSLKLAS 3824
C + F SY+ + + N +I+ T++ A+LL+ N+T ++L++A
Sbjct: 3973 CELNSYGFEELSYMEFPSLDPNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAE 4032
Query: 3825 GVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTS--------- 3875
+ Y+ G Y L++ + V+D +H+++ + L VDS
Sbjct: 4033 ERLRFSYNLGSGTY-KLTTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSN 4091
Query: 3876 -LVVPENCRGLRPERHLLLGGL-----ILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPG 3929
V + ++P R + +GG+ IL S F GC+ VN L+ P
Sbjct: 4092 VAVSDDWTLDVQPNR-VTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLE---PS 4147
Query: 3930 KTVAGLLETQALTQCCLHSDYCSQNTCLNGGKC----SWTHGAGYVCKCPPQFSGKHCEQ 3985
+ +A L QC C+++ C +GG C SW C C +GK+CE+
Sbjct: 4148 QALAA---QGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQ-----CHCKEGLTGKYCEK 4199
Score = 55.8 bits (133), Expect = 9e-07
Identities = 62/268 (23%), Positives = 105/268 (39%), Gaps = 51/268 (19%)
Query: 3846 HVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHSSSNV 3905
+V D WH+ L+ + + L VD + N ++ P G + LGG+ + +
Sbjct: 4298 YVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGIPPNQAHRDA 4357
Query: 3906 -SQGFEGCLDAVVVNEEALDLLAPGK-TVAGLLETQ-------------ALTQC-----C 3945
+ GF+GC+ ++ E+L GK ++A + +T A C C
Sbjct: 4358 QTAGFDGCIASMWYGGESLPF--SGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLC 4415
Query: 3946 LHSDY---------CSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCL 3996
++ Y C+ + C NGG C +G+ C CP +G+ CE CL
Sbjct: 4416 INQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEM------VVACL 4469
Query: 3997 EGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAV 4056
+L P+G C P G C + S+G EI W ++ V
Sbjct: 4470 G----VLCPQGKVCKAGSP-AGHVCVL-----SQG----PEEISLPLWAVPAIVGSCATV 4515
Query: 4057 AFIIISTVGLLFYCRRCKSHKPVAMEDP 4084
+++ ++ L CR K+ P + P
Sbjct: 4516 LALLVLSLILCNQCRGKKAKNPKEEKKP 4543
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 869 bits (2246), Expect = 0.0
Identities = 846/2954 (28%), Positives = 1349/2954 (45%), Gaps = 274/2954 (9%)
Query: 573 IRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ 632
I +D PVG S+ + A D+D L + + +F + +GV+ L++P T +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDN-DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
Query: 633 PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQ 692
++++ + SD + GV+T+
Sbjct: 101 ---FTVEFSVSDHQ---------------------------GVITRKV------------ 118
Query: 693 ESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVY 752
++ +N P F + P S+ + E+ P+ TP+ + ATDPD G G ++Y
Sbjct: 119 --------NIQVGDVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY 169
Query: 753 VIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVK 811
++ F I+ G++TV LDYE T Y L V D T S+ L + +
Sbjct: 170 SFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
Query: 812 DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLH 869
D D P F Y I E + GTT+ +T D D + YT++S F+L
Sbjct: 228 DVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALD 287
Query: 870 PLTGELVVTGHLDRESEPRY----ILKV---EARDQPSKGHQLFSVTDLIITLEDVNDNS 922
++G L + G LDRE+ P Y IL V E D + + T I+ + D+NDN+
Sbjct: 288 YISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI-DINDNA 345
Query: 923 PQCITEHNRLKVPEDLPPGTVLT-FLDASDPD----LGPAGEVRYVLMDGAHGTFRVDLM 977
P+ + + + E G L F+ D D L EV V + H +
Sbjct: 346 PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSV 405
Query: 978 TGALILERE----LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFA 1033
G + LD+E Y+ L+A++ + + +V + +NEN + P F+
Sbjct: 406 QGKADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFS 461
Query: 1034 SFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLA 1093
++ + EN GT V+ V A D+D+G GE+ YF FS+++DTG+I +A
Sbjct: 462 QPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIMLIA 519
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG 1153
LD E + LT++A D G + V I V D NDN P + + +++E+ P
Sbjct: 520 RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSV 577
Query: 1154 TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFM---IHPVTGLLSTAQQLDRENKDEHIL 1210
T +++L A D DS ++T++I S + G + ++ G++S ++ LD E ++
Sbjct: 578 TQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLI 637
Query: 1211 EVTVL--DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVA 1268
+TV+ D G P L ST V + + D NDNPP FS + V + E + ++ V L A
Sbjct: 638 YLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI--MAGATVLFLNA 695
Query: 1269 SDLDEGLN---GRVTYSIEDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILTIKATDSG 1322
+DLD + YS+E S + F I+ +G ++++S T EY IL ++A D G
Sbjct: 696 TDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY-ILIVRAVDGG 752
Query: 1323 ----QPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---G 1375
Q A+V + + I + P D YY V T P + + V++V+ G
Sbjct: 753 VGHNQKTGIATVNITLLDIN----DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
Query: 1376 RPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYN-------LTVEVTDGSRT 1428
G ++I +K + + TTG I + R + + + V VTD R
Sbjct: 809 ENGTLVYSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
Query: 1429 ---IATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYT 1484
+ +F+ + ++N + P F + V + GV + +V AID D+G + + +
Sbjct: 867 PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926
Query: 1485 IHGSQDPGSASL-FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTI 1543
G + F ++ SSGV+VT +LD +++ L V+ D P K + +TI
Sbjct: 927 YR--MPVGMPRMDFLINSSSGVVVTTTELDR-ERIAEYQLRVVASDAGTPTKSSTSTLTI 983
Query: 1544 HVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFF 1603
HV D N P F Y SV + + ++ + D D G+NAE+ Y + GN +G F
Sbjct: 984 HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKF 1043
Query: 1604 NINALLGIITLAQKLDQANHAPHTLTVKAEDQG--SPQWHDLATVIIHVYPSDRSAPIFS 1661
++ ++ LD+ A + L ++A D G + ATV + V + + PIF
Sbjct: 1044 SVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFL 1103
Query: 1662 KSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLIST-Q 1715
+S Y +PE IP G IL + A E V Y + GN F ++ +GL+
Sbjct: 1104 QSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGP 1163
Query: 1716 KKLDHEKISSYQLKIRGSN--MAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQ-ISEAAP 1772
+ LD E+ SS+ L + N + + V V+V + D ND AP+F + + + E A
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
Query: 1773 LYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYES 1832
+ + ++ V+ A+D D L+ Y+IL KF +ID S G + V+ +DYE+
Sbjct: 1224 IGTSVI-------VVQATDRDSGDGGLVNYRILSGAEGKF-EIDESTGLIITVNYLDYET 1275
Query: 1833 MPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELL 1892
S+ V DQ P F V I + + D +FS YE AI+ + G E++
Sbjct: 1276 KTSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIV 1333
Query: 1893 MVRASDEDS--EVNYSIKTGNADEAVT---IHPVTGSISV--LNPAFLGLSRKLTIRASD 1945
V+A D+ ++ Y + +A I +TG I+V L G LT+ A D
Sbjct: 1334 RVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1393
Query: 1946 GLYQDTALVKISLTQV--LDKSLQFDQDVYWA-AVKEN--LQDRKALVILGAQGNHLNDT 2000
G + + VK+ +T + D S +FD A ++ E+ + R A V N
Sbjct: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
Query: 2001 LSYFLLNGT--DMFHMVQSAGVLQTRGVA--FDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
+ + L +G F +V + + VA DRE+ D + L V D TP R ++
Sbjct: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
Query: 2057 RVSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT- 2114
+V+I D+NDNPP + Y + + G + QV ATD D+G N ++Y E
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Query: 2115 -YFRIDPYLGDISLKK-PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPL 2170
FR+D G+I+ + P D + + YHL D GTP+L + V VT+ N + P+
Sbjct: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
Query: 2171 FQSPYYKVRVPENI-TLYTPILHTQA----RSPEGLRLIYNIVEEEPLMLFTTDFKTGVL 2225
FQ P+Y+V + E TL T ++ QA P G + Y IV + F D GV+
Sbjct: 1634 FQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVI 1692
Query: 2226 TVTGPLDYE-SKTKHVFTVRATDT----ALGSFSEATVEVLVEDVNDNPPTFSQ-LVYTT 2279
T LDYE S ++ V ATD + S TV V V D+NDN PTF +
Sbjct: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF 1752
Query: 2280 SISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQ--EL 2337
++EG P V LA D+DSG N V Y I+ DG + +F I+ G + + EL
Sbjct: 1753 EVTEGQPGPR-VWTFLAHDRDSGPNGQVEYSIM-DGDPLGEFV-ISPVEGVLRVRKDVEL 1809
Query: 2338 DYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
D E +++ + A D+G PPL+ LV + V DINDN P +SE +
Sbjct: 1810 DRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSF 1869
Query: 2398 VLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGAS 2457
V V A D DS +RL + I +GN++R FFIN+++GI+++ + Y L +
Sbjct: 1870 VAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVK 1929
Query: 2458 DGVFRATVP------VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL----LAID 2507
D + + I ++ N P F + Y+AE+ EN+ GT + L LA+D
Sbjct: 1930 DNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALD 1989
Query: 2508 KDSGPYGTIDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGG 2564
D Y + Y ++ S F IN + + T++ +DRE + ++ + ++A D G
Sbjct: 1990 ADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL 2048
Query: 2565 RVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
+ + I + D+NDN P F + TV + N V+QV A D D G N ++ Y +
Sbjct: 2049 LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI 2108
Query: 2625 NPEDLVKDVIEINPVTGVVKVKDSLVGLENQ-TLDFFIKAQDGGPPHWNSLVPVRLQVVP 2683
E +D I+ VTGV++V ++ + E Q + + A D G + V + +
Sbjct: 2109 --EAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166
Query: 2684 KKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPES-------N 2735
S P+F P+ T S E G+ I + A+ +P + + G + N
Sbjct: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPN 2226
Query: 2736 KDGVFSLDPDTGVIKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDV 2790
++ F+++ +TG + V+ PM+ E Y+ ID + + + V + + V DV
Sbjct: 2227 QEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
Query: 2791 NDNRPVFEA---DPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS--ADPGSNVH 2845
NDN P F+ Y + E GT++I V A+D D G +G V+Y L PG
Sbjct: 2287 NDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQL 2346
Query: 2846 ELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPR 2905
E DS +G + + +D E +F V A D+G + +++ V + I D NDN P
Sbjct: 2347 E----DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPR-AAEIPVYLEIVDINDNNPI 2401
Query: 2906 FASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV-GDEW 2964
F Y+ +V E+ G ++ T+ DAD N + Y + GD +F I+ GD +
Sbjct: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEY-SLGDGESKFAINPTTGDIY 2458
Query: 2965 RISSRKTLDREHTAKYLLRVTASDG-------KFQASVTVEIFVLDVNDNSPQCSQLLYT 3017
+SS LDRE Y+L A D + + SV V I VLDVND PQ S+ ++
Sbjct: 2459 VLSS---LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
Query: 3018 GKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRER 3077
V+E+ G ++ + ATD D N ++TYSL GPG F +D +G +TT L
Sbjct: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYE 2575
Query: 3078 KDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFF--PSHCAVAVFDNTTVKTPVA 3133
K F+L ATDGG L VE DVNDN P F P+ + + + +++ V
Sbjct: 2576 K--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2633
Query: 3134 VVFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRA 3189
V+A D D+G N V YS +A F ID +G+I+ + L QA L + A
Sbjct: 2634 EVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVA 2693
Query: 3190 SDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS------VQVPEDAPPGTEVLQLATL 3243
SDLG P+P T+ + V++ ++D P+F+ + VPE +P GT V +
Sbjct: 2694 SDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA 2753
Query: 3244 TRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSS-- 3298
Y + +GNE+ F L G L V LD E + ++ S S
Sbjct: 2754 VDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWT 2812
Query: 3299 ---------SSLSDVT--TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATD 3347
++D+T V V + D+N+ P+F + Y+ V +A VG ++ V A D
Sbjct: 2813 PPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALD 2872
Query: 3348 EDGPLNSDITYSLI 3361
D NS + YS++
Sbjct: 2873 ADIGNNSLVFYSIL 2886
Score = 812 bits (2097), Expect = 0.0
Identities = 812/2924 (27%), Positives = 1317/2924 (45%), Gaps = 240/2924 (8%)
Query: 706 QINHYTPQFEDHFPQS-IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Q+N P F +HF + + + E P+ + + +L A D D N LV+ ++ F
Sbjct: 24 QVNRL-PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFA 79
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
+E +TG++ + PLD E + + + +V D Q + + + V D NDNAP F
Sbjct: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP 136
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Y + I E+T VGT I + D D G V Y+ P++ F++ G + V LD E
Sbjct: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE 196
Query: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVL 944
+ Y L V A DQ K L ++ +L I + DV D P I + E PPGT +
Sbjct: 197 TTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
Query: 945 TFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFER---RAGYNLSLW 1000
+ A D D G + Y ++ G + F +D ++G L L LD E G+ L++
Sbjct: 256 RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
Query: 1001 A---SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV---IVV 1054
+D P ++V+D+N+N P F S + + E + G + I V
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQV 373
Query: 1055 AAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM------IQTLAPLDREFASYYWLTVL 1108
+D++ GL+ + +L G F I+ + I+ PLD E Y +
Sbjct: 374 VDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
Query: 1109 AVDRGSVP-LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSS 1167
A + SVP +V I + + NDN P SQ ++ S+ E+ VGTSVL + A D D+
Sbjct: 433 ANE--SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
Query: 1168 SKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSR 1227
+ G++++ + F + TGL+ +LD E L + D G ++T R
Sbjct: 491 TFGEVSYFFSDD--PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGR 546
Query: 1228 VVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD 1287
V + +LDVNDN P F + L E V+ + RL A+D D N ++TYSI +
Sbjct: 547 VRINVLDVNDNVPTFQKDAYVGALRENEPSVT--QLVRLRATDEDSPPNNQITYSIVSAS 604
Query: 1288 E--EAFSIDLVT--GVVSSSSTFTAGEYN----ILTIKATDSGQPPLSASVRLHIEWIPW 1339
F I L GV+S S + + LT+ A D+G PPL+++V + IE
Sbjct: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD- 663
Query: 1340 PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE--------GRPGLFWFNISGGDKDM 1391
+ P F + Y +V+E V ++ G+ + +++ G +
Sbjct: 664 --ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSTQ-- 718
Query: 1392 DFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG-----SRTIATQVHIFMIANINHHRP 1446
F I +G I LD +S Y L V DG +T V+I ++ +IN + P
Sbjct: 719 -FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL-DINDNHP 776
Query: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK--SLIYTIHGSQDPGSASLFQLDPSSG 1504
+ + Y + + + T P ++ V A+D D G+ +L+Y+I Q P + L+ ++G
Sbjct: 777 TWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---QPPN--KFYSLNSTTG 831
Query: 1505 VLVTVGKLDLGSGPSQH------TLTVMVRD-QEIPIK-RNFVWVTIHVEDGNLHPPRFT 1556
+ T + P H + V V D P+K + V +++ D N + P F
Sbjct: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
Query: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ 1616
L + A V + I G + QV A+D D G+N V Y + G F IN+ G++
Sbjct: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951
Query: 1617 KLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVG 1676
+LD+ A + L V A D G+P +T+ IHV + P F + Y V + E +P
Sbjct: 952 ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011
Query: 1677 SPILLVSAMS-----PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIR 1731
++ ++ +E++Y + GN DG FS+ ++ T LD E ++Y L +
Sbjct: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILE 1071
Query: 1732 -------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP 1784
G G T V V ++D NDN P+FL+S++ + E P + ++
Sbjct: 1072 AIDNGPVGKRHTGTAT---VFVTVLDVNDNRPIFLQSSYEASVPEDIP-------EGHSI 1121
Query: 1785 FVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI-VSEMDYESMPSFQFCV--Y 1841
+ A+D+D+ + Y+IL F+I S G L +D E S V Y
Sbjct: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
Query: 1842 VHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY-EVAIVGPIHPGMELLMVRASDED 1900
HD G P+ + R VI++V D+ND P F++Q Y + + G +++V+A+D D
Sbjct: 1182 NHDLG-PMRSSVR---VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
Query: 1901 SE----VNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLYQ 1949
S VNY I +G A+ I TG I +N +L K + + A+D Q
Sbjct: 1238 SGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAPPFNQ 1294
Query: 1950 DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG-NHLNDTL----SYF 2004
V I+L LD+++QF Y AA+ ENL +V + A ++LN +Y
Sbjct: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYT 1354
Query: 2005 LLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
+F + GV+ +G+ DRE+ D + L V V D+ P+ + V +++ D N
Sbjct: 1355 STQAKALFKIDAITGVITVQGLV-DREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDEN 1412
Query: 2065 DNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAED-----YTYFRI 2118
DN P+F + I + G + V A D D G+NG V + A +
Sbjct: 1413 DNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTT 1472
Query: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPY- 2175
+ +G++ + +P D + L+ Y L+V+A D GTP + + + VT+ N + P+ +SP+
Sbjct: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
Query: 2176 YKVRVPENITLYTPILHTQARSPE-GLR--LIYNIVEEEPLMLFTTDFKTG-VLTVTGPL 2231
Y V V EN+ T ++ +A + G+ L Y I E M F D +G + T P
Sbjct: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPP 1592
Query: 2232 DYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISEGLPA-QT 2289
D E ++ + D + S T V V + D NDN P F Q Y + EG T
Sbjct: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
Query: 2290 PVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE-AQQHFHVK 2348
+I + A D D G N V+Y IV ++ F+I+ G ++ +ELDYE + + +
Sbjct: 1653 SLITIQALDLDEGPNGTVTYAIV--AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
Query: 2349 VRAMDKG---DPPLTGETLVVVNVSDINDNPPEF-RQPQYEANVSELATCGHLVLKVQAI 2404
V A D+ LT T V+VNV+DINDN P F R + V+E G V A
Sbjct: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAH 1769
Query: 2405 DPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK--KHLDSSYNLRVGASD---G 2459
D DS ++EY I+ G+ F I+ G++ + + + + YNL + A D
Sbjct: 1770 DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMP 1829
Query: 2460 VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
+T+ V I + N P ++EN+ V + V +LA D DSG + +
Sbjct: 1830 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFN 1889
Query: 2520 IINKLASEKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDGGGRVA---FCTVKIIL 2575
I F IN I T+ + LDRE E + I V R+A + + I L
Sbjct: 1890 ITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFL 1949
Query: 2576 TDENDNPPQFKASEYTVSIQSNVSKDSPVI----QVLAYDADEGQNADVTYSVNPEDLVK 2631
+DENDN P F S Y + N +P+ +LA DAD+ A VTY +
Sbjct: 1950 SDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ--S 2007
Query: 2632 DVIEINPVTGVVKVKDSLV----GLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVS 2687
+ +IN TGVV V+ ++ L+ + A+D G NS + + ++ +
Sbjct: 2008 GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITILDDNDN 2065
Query: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTG 2747
P FS T E+ P G + V A + LV E+ F + TG
Sbjct: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTG 2123
Query: 2748 VIKV-RKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVL 2806
VI+V +D E + Y++ V+A + V I + D+ND+RP F +
Sbjct: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
Query: 2807 TENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGS--------NVHELFAIDSESGWIT 2858
E+ GT + +TAID D + ++ Y + N + FA++ +G +
Sbjct: 2184 LESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
Query: 2859 TLQELDCETCQTYHFHVVAYDHGQTIQLSS----QALVQVSITDENDNAPR---FASEEY 2911
++ E TY + D+ + S A + V++ D NDN P+ F Y
Sbjct: 2242 VKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYY 2301
Query: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971
++E + PG + + +D D N VT + + P G + ++ + +T
Sbjct: 2302 MERILEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRT 2359
Query: 2972 LDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
+D E V ASD A + V + ++D+NDN+P Q Y V EDV G
Sbjct: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
Query: 3029 FILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKAT 3088
IL V+ATD D+ A I YSL G G +F ++P TG++ L++LDRE+KD + L A A
Sbjct: 2420 IILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAK 2478
Query: 3089 DGGG------RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQ 3142
D G R + + V DVND P+F + +V++N T V + A D D+
Sbjct: 2479 DNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDE 2538
Query: 3143 GANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202
G N ++ YSL F +D +G++ ++PLQ LTV A+D G P PL
Sbjct: 2539 GPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP-PLWGTT 2595
Query: 3203 TVTVSVVGLEDYLPVFLNTEHS--VQVPEDAPPGTEVLQLATLTRP----GAEKTGYRVV 3256
+ V V+ + D PVF+ + + + E+ P + V ++ + GA + +
Sbjct: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT 2655
Query: 3257 SGNEQGR-FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS-SLSDVTTVMVNITDV 3314
+GN F +D +G++ LD E+ Y L + S + + V + D+
Sbjct: 2656 AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDI 2715
Query: 3315 NEHRPQFPQDPYST------RVLENALVGDVILTVS-ATDEDGPLNSDITYSLIGGNQLG 3367
+++ P F + P + V E++ G ++ V+ A D D N+ + Y + GN+
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775
Query: 3368 HFTIHPKKGELQVAKALDREQASSYSLKLRATDS--------GQPPLHEDTDIAIQ---- 3415
+F + P G L V + LDRE+ + +S ++A+ + P L D+ +Q
Sbjct: 2776 NFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRV 2834
Query: 3416 -VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPEN 3458
+ D+ND PPRF + Y+ V ++ +GS+++Q++ D D N
Sbjct: 2835 VLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
Score = 775 bits (2002), Expect = 0.0
Identities = 796/2950 (26%), Positives = 1311/2950 (44%), Gaps = 268/2950 (9%)
Query: 827 LTISEDTEVGTTIAELTTKDADSED-----NGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881
L ISEDT VG+++ +L +D D++ +G + F++ P TG + + L
Sbjct: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPL 93
Query: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
DRE++ + ++ D HQ + I + DVNDN+P + +++PE+ P G
Sbjct: 94 DRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001
T + ++A+DPDLG G V Y + F +D G + + RELD+E Y L++ A
Sbjct: 149 TPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
Query: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061
+D + TL ++ +I+ DV + P F + + + E+SP GT V ++ A D D
Sbjct: 208 TDQDKTRPLSTLANLAIIITDVQDM--DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
Query: 1062 GLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV-------DRGS 1114
G + Y + +G + F+++ +G++ LDRE Y +L V DR
Sbjct: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 1115 VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV-LQLDAWDPDSSSKGKLT 1173
+ T I V D NDN P+ + + + +I E A VG ++ L + D D +
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
Query: 1174 FNI-TSGNYMGFFMIHPVTGL------LSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS 1226
F + GN F+I P + + A LD E D + ++ + P +
Sbjct: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYA 444
Query: 1227 RVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS 1286
+V + +++ NDN PIFS L+N+ L E ++ + V ++A+D D G G V+Y D
Sbjct: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVSYFFSD- 501
Query: 1287 DEEAFSIDLVTGVVSSSSTFTAGEYNI-----LTIKATDSGQPPLSASVRLHI----EWI 1337
D + FS+D TG++ + +Y + LTI A D G + VR+++ + +
Sbjct: 502 DPDRFSLDKDTGLIMLIARL---DYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
Query: 1338 PWPRPSSIPLAFDETYYSFTVM-------ETDPVNHMVGVISVEGRPGLFWFNISGGDKD 1390
P + + A E S T + E P N+ + V +F+IS
Sbjct: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS----- 613
Query: 1391 MDFDIEKTTGSIVIARPLDTRRRSN--YNLTVEVTDGSR-----TIATQVHIFMIANINH 1443
+ + G I ++RPLD + SN LTV D T+ + +F + N
Sbjct: 614 ----LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF---DEND 666
Query: 1444 HRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK-----SLIYTIHGSQDPGSASLFQ 1498
+ P F + Y V V ++ + G +L + A D D+ + S+IY++ GS F+
Sbjct: 667 NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FR 720
Query: 1499 LDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPI--KRNFVWVTIHVEDGNLHPPRFT 1556
++ SG + T LD + S++ L V D + K V I + D N + P +
Sbjct: 721 INARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
Query: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII-TLA 1615
Y ++ + P +++ V A+D D G N + YS+ N F+++N+ G I T
Sbjct: 780 DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTH 837
Query: 1616 QKLDQANHAPHT------LTVKAEDQGSPQWH--DLATVIIHVYPSDRSAPIFSKSEYFV 1667
LD+ N PH + V D G P ATV +++ + + P F +
Sbjct: 838 AMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVA 897
Query: 1668 EIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEK 1722
E+ E IP G I V A+ E V+Y + G F +NS SG++ T +LD E+
Sbjct: 898 EVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRER 957
Query: 1723 ISSYQLKIRGSNMAGAFTDVM---VVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMD 1779
I+ YQL++ S+ AG T + + ++D ND P F + + +SE P ++
Sbjct: 958 IAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
Query: 1780 KNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFC 1839
N +D+D N+ L Y I F + + V +D E+ ++
Sbjct: 1017 LN-------CTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
Query: 1840 VYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899
+ D G A V + V DVND+ P F + YE ++ I G +L ++A+D
Sbjct: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
Query: 1900 DS----EVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLY 1948
D V Y I GN IH V+ + + P L R L + A + G
Sbjct: 1130 DEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPM 1188
Query: 1949 QDTALVKISLTQVLDKSLQFDQDVYWA-AVKENLQDRKALVILGAQGNHLND--TLSYFL 2005
+ + V + + + D++ F Q Y ++E +++++ A D ++Y +
Sbjct: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI 1248
Query: 2006 LNGTD-MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
L+G + F + +S G++ T D E + ++ + V D P V +++ +
Sbjct: 1249 LSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
Query: 2065 DNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-----AEDYTYFRID 2119
D +F + Y I + G + +V A D +TY F + F+ID
Sbjct: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKID 1365
Query: 2120 PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQ-SPYY 2176
G I+++ D + + Y L V+A DGG P + S +V +TV N ++P F +
Sbjct: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
Query: 2177 KVRVPENITLYTPILHTQARSPEGL---RLIYNIVEEEPLMLF---TTDFKTGVLTVTGP 2230
V +PE+ + + +A P+ ++++++ F TT+ G + V P
Sbjct: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
Query: 2231 LDYESKTKHVFTVRATDTALGSFSEATV-EVLVEDVNDNPPTF-SQLVYTTSISEGLPAQ 2288
LD E ++ V A+D + + +V + D+NDNPP S Y S++E +
Sbjct: 1485 LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGG 1544
Query: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMST-VQELDYEAQQHFHV 2347
T V+Q+ A+D+D G N +SY I E D++ F+++ +GE++T D E Q +H+
Sbjct: 1545 TAVVQVRATDRDIGINSVLSYYITEGNKDMA--FRMDRISGEIATRPAPPDRERQSFYHL 1602
Query: 2348 KVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELA-TCGHLVLKVQAIDP 2406
D+G P L+ T V V + D NDN P F+QP YE + E T ++ +QA+D
Sbjct: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDL 1662
Query: 2407 DSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD-----SSYNLRVGASDGV- 2460
D + Y I++GN F I+ G+I+ K LD Y L V A+D
Sbjct: 1663 DEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT----AAKELDYEISHGRYTLIVTATDQCP 1718
Query: 2461 -----FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGT 2515
+T V +N + N P F + G +V LA D+DSGP G
Sbjct: 1719 ILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQ 1778
Query: 2516 IDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGGRVAFCT-- 2570
++Y+I++ +F I+P + ++K LDRE T + + ARD G T
Sbjct: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRE--TIAFYNLTICARDRGMPPLSSTML 1836
Query: 2571 VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLV 2630
V I + D NDN P ++I N S V VLA DAD G NA +T+++ +
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE 1896
Query: 2631 KDVIEINPVTGVVKVKDSL--VGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP-KKVS 2687
+ IN TG+V V L + L +K P + L + + +
Sbjct: 1897 RAFF-INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
Query: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDP 2744
P F++ Y E+ P G+ + ++ D IY++V + + G+F ++
Sbjct: 1956 HPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINS 2014
Query: 2745 DTGVIKVRKPM--DHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPY 2802
TGV+ VR + D E+ ++++ + S + I + D NDNRP F
Sbjct: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATL 2074
Query: 2803 KAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQE 2862
L EN P G SV+QVTA D+D+G +G++ YR+ A + F I +G I
Sbjct: 2075 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA----GAQDRFLIHLVTGVIRVGNA 2130
Query: 2863 -LDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEP 2921
+D E ++Y VVA D G T+ LS A+V + I D ND+ P F + SV+E++EP
Sbjct: 2131 TIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189
Query: 2922 GELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG------DEWRISSRKTLDRE 2975
G ++A + +D D++ + I D + +Q + + + ++RE
Sbjct: 2190 GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249
Query: 2976 HTAKYLLRVTASDGKF---QASVTVE-----IFVLDVNDNSPQCSQL---LYTGKVHEDV 3024
A Y + ++ D + SV+V + VLDVNDN+PQ Y ++ E
Sbjct: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309
Query: 3025 FPGHFILKVSATDLDTDTNAQITYSLHG---PGAHEFKLDPHTGELTTLTALDRERKDVF 3081
PG ++ V+A D D N +TY+L PG + + D G++ +D E
Sbjct: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWL 2368
Query: 3082 NLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARD 3139
N +A+D G R+ + + L + D+NDN P F AVF++ V T + V A D
Sbjct: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
Query: 3140 PDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
D G A + YSL D E F+I+ TTG I + L + LT A D + +
Sbjct: 2429 ADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
Query: 3200 TLGT---VTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR---PGAEKTGY 3253
V + V+ + D P F + S V E+ P GT V+ + + P E T
Sbjct: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS 2547
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITD 3313
G E F +D +G++ L ++ K+ L++ + L T ++V + D
Sbjct: 2548 LEGPGVEA--FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 2603
Query: 3314 VNEHRPQFPQDPYST--RVLENALVGDVILTVSATDEDGPLNSDITYSLI---GGNQLGH 3368
VN++RP F + P T + E + + V ATD+D LN + YS + G
Sbjct: 2604 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEF 2663
Query: 3369 FTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTD-IAIQVADVNDNPPRFF 3427
F I P G +Q A+ LDRE + YSL L A+D GQP +E + + + D++DN P F
Sbjct: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFV 2723
Query: 3428 QLNYST------TVQENSPIGSKVLQLILS-DPDSPENGPPYSFRITKGNNGSAFRVTPD 3480
+ + TV E+SP G+ V + + D D N Y F I GN F + PD
Sbjct: 2724 RPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF-IAAGNEEKNFHLQPD 2782
Query: 3481 GWLVTAEGLSRRAQEWYQLQIQASD--SGIPPLS-----------SLTSVRVHVTEQSHY 3527
G L+ L R + + ++AS S PP +L VRV + + +
Sbjct: 2783 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842
Query: 3528 APSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYSLA----------EEETLG 3575
P E V D G + ++ A D D + YS+ + E +G
Sbjct: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVG 2902
Query: 3576 RHFSVGAPDG 3585
+ F++G+ DG
Sbjct: 2903 QVFTMGSMDG 2912
Score = 747 bits (1929), Expect = 0.0
Identities = 770/2806 (27%), Positives = 1261/2806 (44%), Gaps = 287/2806 (10%)
Query: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92
F + Y+ IYE+S P T V + P+ + Y I+SG+ ++F + Y+ G
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR-GIGYTIVSGNTNSIFALD-YISGVL 293
Query: 93 CFLRIRTKSSNTALLNRE---VRDSYTLIIQATEKT-----LELEALTRVVVHILDQNDL 144
LL+RE + L ++ TE + T + ++D ND
Sbjct: 294 TL---------NGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDN 344
Query: 145 KPLFSPPSYRVTISE------DMPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIH 197
P F+ Y V I+E +PL +V D +LG N+ F Y S F I
Sbjct: 345 APEFNSSEYSVAITELAQVGFALPL---FIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS 401
Query: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRM-------RKISEGNGFGSLAALVVHVE--- 247
PTS V GK ++ R L VDR + + G+ + +++
Sbjct: 402 PTS----VQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYA 307
P +P S+ + GT+ TVL N +G E DP + ++
Sbjct: 458 PIFSQPLYNISLY---ENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR-------FS 507
Query: 308 RSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVY 367
+ L+ + E + F L++ AR G G ++R ++ + F+K Y
Sbjct: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVR-INVLDVNDNVPTFQKDAY 566
Query: 368 RVQLSEFSPPGSRVVMVRVTP--AFPNLQYVLKPSSENV-----GFKLNARTGLITTTKL 420
L E P +++V +R T + PN Q S + L G+I+ ++
Sbjct: 567 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626
Query: 421 MDFHDRAHYQLHIRT------SPGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPP 473
+D+ ++ +++ +P STV V I++ D N++ P F++ +Y ++ ENI
Sbjct: 627 LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA 686
Query: 474 GTSVLAVTATD----RDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIY 529
G +VL + ATD R++G+ + YS+ G + F I+ G I+T+ +D E K Y
Sbjct: 687 GATVLFLNATDLDRSREYGQES-IIYSLEG--STQFRINARSGEITTTSLLDRE-TKSEY 742
Query: 530 TFRVRASDWGSPFRREKEV-SIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588
VRA D G ++ + ++ + L ++NDN P +++ ++ + P + T+ A
Sbjct: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
Query: 589 IDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSL--KITASD 644
+D D +N L Y I N +++ LN +G I ++ P L KI S
Sbjct: 803 VDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS- 859
Query: 645 GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
V D C + + + T+ F+ L + +D F +L
Sbjct: 860 --------------VTD--------CGRPPLKATSSATV--FVNLLDLNDNDPTFQNL-- 893
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
P +VLE +P + ++ A D D G NG + Y + G F
Sbjct: 894 --------------PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I +G++ LD E Y L V D GTP KSS LT++V D ND P F P
Sbjct: 940 INSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV 999
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLD 882
Y +++SED + L D D N + Y + + KFS+ + LD
Sbjct: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLD 1059
Query: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942
RE+ Y+L +EA D G + + +T+ DVNDN P + VPED+P G
Sbjct: 1060 RETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
Query: 943 VLTFLDASDPDLGPAGEVRYVLMDGAHG-TFRVDLMTGALIL-ERELDFERRAGYNLSLW 1000
+ L A+D D G G V Y ++ G HG FR+ + G L+ R LD ER + + L +
Sbjct: 1120 SILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
Query: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
A + R ++ V V V D+N+ P + ++E + GT VIVV A D D
Sbjct: 1180 AYNHDLGPMRSSV-RVIVYVEDINDEA-PVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
Query: 1061 SGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV 1120
SG G + Y + +G F I++ TG+I T+ LD E + Y + V A D+
Sbjct: 1238 SGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
Query: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-ITSG 1179
VYI + + D Q S A + +I E+ +GT ++++ A+ D+ ++ FN TS
Sbjct: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTST 1356
Query: 1180 NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNP 1239
F I +TG+++ +DRE D + L V V D+G P + ST +V + +LD NDN
Sbjct: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNS 1415
Query: 1240 PIFSHKLFN-VRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG 1298
P F + V +PE PV V + A D D G NG+V +S+ S A + ++VT
Sbjct: 1416 PRFDFTSDSAVSIPED-CPVGQ-RVATVKAWDPDAGSNGQVVFSLA-SGNIAGAFEIVTT 1472
Query: 1299 VVSSSSTFTAG-------EYNILTIKATDSGQPPLSASVRLHIEWIPW-PRPSSIPLAFD 1350
S F A ++ IL + A+D G PP L + + P I
Sbjct: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI----- 1527
Query: 1351 ETYYSFTVMETDPVNHMVGVISVE------GRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404
E+ + + V + V V+ V G + + I+ G+KDM F +++ +G I
Sbjct: 1528 ESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
Query: 1405 -ARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQ-- 1459
P D R+S Y+L V D G+ T++ H+++ I + N + P F + YEV + +
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
Query: 1460 DTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519
DT+ L+ +QA+D D+G + T + + F++D GV+ +LD
Sbjct: 1648 DTL-NTSLITIQALDLDEGPNGTVT-YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
Query: 1520 QHTLTVMVRDQEIPI----KRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIA-PGTEL 1574
++TL V DQ PI + V ++V D N + P F + YE T PG +
Sbjct: 1706 RYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPR-DYEGPFEVTEGQPGPRV 1763
Query: 1575 LQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ--KLDQANHAPHTLTVKA 1632
A D D G N +V YS++ G+ G F I+ + G++ + + +LD+ A + LT+ A
Sbjct: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
Query: 1633 EDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP----- 1687
D+G P V I V + + P+ + I E+ PV S + V A
Sbjct: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
Query: 1688 SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDV- 1742
+ +T+ + GN++ F +N+ +G+++ + LD E+I Y+L I N A D
Sbjct: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
Query: 1743 MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
++++ + DENDN P+F KST+ ++ E +P + + N I A D+D++ +++ Y
Sbjct: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNG---PILALDADQDIYAVVTY 2000
Query: 1803 KILEPEALKFFKIDPSMGTLT----IVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQV 1858
++L ++ F I+ S G +T ++ + + S P + + D G A +
Sbjct: 2001 QLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAHL 2055
Query: 1859 IIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADE 1914
+I + D ND+ P FS V ++ PG +L V A+DEDS +N Y I+ G A +
Sbjct: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
Query: 1915 AVTIHPVTGSISVLNPAF---LGLSRKLTIRASDG---LYQDTALVKISLTQVLDKSLQF 1968
IH VTG I V N S +LT+ A+D TA+V I + + D +F
Sbjct: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
Query: 1969 DQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLL-------------NGTDMFHMV 2015
+ +V E+ + + + A + LN L Y ++ N D F +
Sbjct: 2175 LNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVN 2234
Query: 2016 QSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQR---VAQGLVRVSIEDVNDNPPKF 2070
+ G + + +RE T+E+ + V DN + P+R V + V++ DVNDN P+F
Sbjct: 2235 INTGSVMVKS-PMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
Query: 2071 KHLP---YYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE----DYTYFRIDPYLG 2123
K Y I +G PG L V+A D D G NG VTY + Y D G
Sbjct: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-DSSAG 2352
Query: 2124 DISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVP 2181
+ + DY+ ++ + V A D G+P +E V + + N +NP+F P Y+ V
Sbjct: 2353 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
Query: 2182 ENITLYTPIL---HTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTK 2238
E++ + T IL T A S + Y++ + E F + TG + V LD E K
Sbjct: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLDREKKDH 2470
Query: 2239 HVFTVRATDT---ALGSFSEATVEVLVE--DVNDNPPTFSQLVYTTSISEGLPAQTPVIQ 2293
++ T A D + E +V+V+++ DVND P FS+ ++TS+ E PA T VI
Sbjct: 2471 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVIT 2530
Query: 2294 LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
++A+DQD G N +++Y + G + F ++ +G ++T + L ++ + F + V A D
Sbjct: 2531 MMATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSLTVVATD 2585
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEA--NVSELATCGHLVLKVQAIDPDS--R 2409
G+PPL G T+++V V D+NDN P F +P ++ E V +V A D D
Sbjct: 2586 GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLN 2645
Query: 2410 DTSRLEYLILSGNQDRHFF-INSSSGIISMFNLCKKHLDSSYNLRVGASD----GVFRAT 2464
R +L +GN+D FF I+ SG+I + + Y+L + ASD +
Sbjct: 2646 GAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETM 2705
Query: 2465 VPVYINTTNAN----------KYSPEFQQHLYEAELAENAMVGTKVIDLL-AIDKDSGPY 2513
P+ + + + K SP++Q + E++ GT V ++ A+D D GP
Sbjct: 2706 QPLQVALEDIDDNEPLFVRPPKGSPQYQL----LTVPEHSPRGTLVGNVTGAVDADEGPN 2761
Query: 2514 GTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMAR------------- 2560
+ Y I + F + P+G + L+ LDRE +K +
Sbjct: 2762 AIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2821
Query: 2561 DGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADV 2620
D + V+++L D ND PP+F +EYT + ++ S +IQVLA DAD G N+ V
Sbjct: 2822 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2881
Query: 2621 TYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDG 2666
YS+ + + + G V S+ G+ +T D F+ G
Sbjct: 2882 FYSILAIHYFRALANDSEDVGQVFTMGSMDGI-LRTFDLFMAYSPG 2926
Score = 740 bits (1911), Expect = 0.0
Identities = 771/2922 (26%), Positives = 1252/2922 (42%), Gaps = 267/2922 (9%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE + +T+ ++ +TR V + + D ND P F Y V I E+ P+ +
Sbjct: 93 LDRETKSEFTVEFSVSDHQ---GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
Query: 166 PICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
PI V ATD DLG Y+F S+ FAI G+VTV +L+ ++L V A D
Sbjct: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
Query: 226 --RMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL-VDANSS 282
+ R +S + V ++P P ++ P GTT + +D +
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP---GTTVRIITAIDQDKG 266
Query: 283 GAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQA---RSGS 339
+V G+ F Y S +L + D Y HGF L+++
Sbjct: 267 RPRGIGYTIVSGNTNSIFAL--DYI-SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
Query: 340 GPYFYSQIRGFHLPPSKLS--SLKFEKAVYRVQLSEFSPPGSRV-VMVRVTPAFPNL--- 393
P + F++ ++ + +F + Y V ++E + G + + ++V NL
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
Query: 394 -------------QYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-PGQ 439
+++ P+S + R + + +D +D + L S P
Sbjct: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---FDLFANESVPDH 440
Query: 440 ASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA 498
V I +++ N++ P+F++ Y+ +L EN+ GTSVL V ATD D G G V+Y +
Sbjct: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
Query: 499 GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
FS+D G+I +DYEL++R +T + A D G E + + + ++N
Sbjct: 501 DDPDR-FSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGGG---EETTGRVRINVLDVN 555
Query: 559 DNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNEL-EYFDLNHF 615
DN P F++ G++R++ P ++ + A D D N + Y IVS + YFD++ +
Sbjct: 556 DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
Query: 616 SG--VISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKT 673
G VIS+ RP Y L + A D N +T+ +T+ + P T K
Sbjct: 616 EGYGVISVSRPLDYEQISNGLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 674
Query: 674 GVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTP 733
+ V+E++
Sbjct: 675 AYF---------------------------------------------VSVVENIMAGAT 689
Query: 734 LARLAATDPDAG--FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVT 791
+ L ATD D + + + +G+ + F I +G +T + LD E + YIL V
Sbjct: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVR 747
Query: 792 VYDLGTPQKSSWKLLTVNVK--DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADS 849
D G + TVN+ D NDN P + Y + + E T + + + D D
Sbjct: 748 AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
Query: 850 EDNGRVRYTLLSPTEKFSLHPLTGELVVT-GHLDRES------EPRYILKVEARDQPSKG 902
+NG + Y++ P + +SL+ TG++ T LDRE+ E + V D
Sbjct: 808 GENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
Query: 903 HQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY 962
+ S + + L D+NDN P +V E +P G + + A D D G G V Y
Sbjct: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
Query: 963 VLMDGA-HGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021
+ G F ++ +G ++ ELD ER A Y L + ASD G P T + + VL
Sbjct: 928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTST-LTIHVL 986
Query: 1022 DVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFS 1081
DVN+ P F V+ V E+ P +V+ + D+D GL+ EL YF+ G FS
Sbjct: 987 DVNDET--PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
Query: 1082 INQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--SSVTEVYIEVTDANDNPPQMSQ 1139
+ +++T+ LDRE + Y L + A+D G V + V++ V D NDN P Q
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
Query: 1140 AVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ 1199
+ + S+ ED P G S+LQL A D D G++ + I GN+ F IH GLL +
Sbjct: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
Query: 1200 -LDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPV 1258
LDRE H+L V ++ ++S+ RV+V + D+ND P+F+ + ++ RL R +
Sbjct: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETAG 1223
Query: 1259 SPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILT 1315
V + A+D D G G V Y I E F ID TG++ + + T Y ++
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSY-MMN 1282
Query: 1316 IKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEG 1375
+ ATD P ++I + + F Y ++E + + +
Sbjct: 1283 VSATDQAPPFNQGFCSVYITLL---NELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339
Query: 1376 RPGL----FWFNI-SGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIA 1430
L + FN + F I+ TG I + +D + Y LTV DG +
Sbjct: 1340 IDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD 1399
Query: 1431 TQVHIFM-IANINHHRPQF-LETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIH 1486
+ V +++ + + N + P+F + V +P+D G + V+A D D G + +++++
Sbjct: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLA 1459
Query: 1487 GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE 1546
G+ + + S G + LD + L V+ D+ P ++ + + +
Sbjct: 1460 SGNIAGAFEIVTTNDSIGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKDHILQVTIL 1518
Query: 1547 DGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNI 1605
D N +PP + Y SV + + GT ++QVRA D D G+N+ + Y + +GN + F +
Sbjct: 1519 DINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRM 1578
Query: 1606 NALLG-IITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
+ + G I T D+ + + L ED+G+P V + + + +AP+F +
Sbjct: 1579 DRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH 1638
Query: 1665 YFVEIPESIP-VGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKL 1718
Y V + E + + ++ + A+ E VTY + GN F ++ + G+I+ K+L
Sbjct: 1639 YEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKEL 1698
Query: 1719 DHE-KISSYQLKIRGSNMAGAFTDVM-----VVVDIIDENDNAPMFLKSTFVG--QISEA 1770
D+E Y L + ++ + + V+V++ D NDN P F + + G +++E
Sbjct: 1699 DYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEG 1757
Query: 1771 APLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVS--EM 1828
P + A D D N + Y I++ + L F I P G L + E+
Sbjct: 1758 QP--------GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVEL 1809
Query: 1829 DYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPG 1888
D E++ + + D+G P L + V I V D+ND+ P + I
Sbjct: 1810 DRETIAFYNLTICARDRGMPPLSSTM--LVGIRVLDINDNDPVLLNLPMNITISENSPVS 1867
Query: 1889 MELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLT 1940
+ V ASD DS N ++I GN + A I+ TG ++V P L R KLT
Sbjct: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRP--LDRERIPEYKLT 1925
Query: 1941 IRASDG------LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQ- 1993
I D +D L+ I L+ D F + Y A V EN L +L
Sbjct: 1926 ISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPI 1985
Query: 1994 -----GNHLNDTLSYFLLNG-TDMFHMVQSAGVLQTR-GVAFDRE--QQDTHELAVEVRD 2044
+ ++Y LL + +F + S GV+ R GV DRE EL + D
Sbjct: 1986 LALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED 2045
Query: 2045 NRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGA 2104
A L+ +I D NDN P F + + PG + QV+ATDED G NG
Sbjct: 2046 IGLLNSTAHLLI--TILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGE 2103
Query: 2105 VTYEF-AEDYTYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVT 2162
+ Y A F I G I + D + Y L V+A D GT L V +
Sbjct: 2104 LVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTIL 2163
Query: 2163 VR--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GLRLIYNIV------EEEPL 2213
+ N S P F +P V V E+ T I + A + +L Y+IV + + L
Sbjct: 2164 IDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRL 2223
Query: 2214 M-----LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALG------SFSEATVEVLV 2262
+ F + TG + V P++ E + T+ D A S A + V V
Sbjct: 2224 VPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
Query: 2263 EDVNDNPPTFSQL---VYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS 2319
DVNDN P F Y I EG T +I + A D D G N V+Y +++
Sbjct: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPP 2341
Query: 2320 KFFQI-NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPE 2378
+ Q+ + S G++ + +DYE + VRA D G PP E V + + DINDN P
Sbjct: 2342 GYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2401
Query: 2379 FRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISM 2438
F QP Y+ V E G ++L V A D DS + + +EY + G+ + F IN ++G I +
Sbjct: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYV 2459
Query: 2439 FNLCKKHLDSSYNLRVGASDGVFRA-------TVPVYINTTNANKYSPEFQQHLYEAELA 2491
+ + Y L A D +V V I + N P+F + + +
Sbjct: 2460 LSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVY 2519
Query: 2492 ENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTER 2551
EN GT VI ++A D+D GP G + Y++ E F ++ + + T Q R +
Sbjct: 2520 ENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQ---RPLQSYE 2575
Query: 2552 VIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQF--KASEYTVSIQSNVSKDSPVIQV 2607
++ V+A DGG + T +++ D NDN P F + + I+ + S V +V
Sbjct: 2576 KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEV 2635
Query: 2608 LAYDADEGQNADVTYSVNPEDLVKD--VIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
A D DEG N V YS +D I+P++G+++ L + A D
Sbjct: 2636 YATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASD 2695
Query: 2666 -GGPPHWNSLVPVRLQVV------PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA 2718
G P + ++ P+++ + P V PK S + PE P G+ +G V
Sbjct: 2696 LGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVD 2755
Query: 2719 QDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN---- 2774
D ++V N++ F L PD G + V + +D E ++ V A ++
Sbjct: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPP 2814
Query: 2775 ------TDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKD 2825
D+V+ L V + + D+ND P F Y A + + VG+ +IQV A+D D
Sbjct: 2815 RGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDAD 2874
Query: 2826 TGRDGQVSY--------RLSADPGSNVHELFAIDSESGWITT 2859
G + V Y R A+ +V ++F + S G + T
Sbjct: 2875 IGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT 2916
Score = 734 bits (1895), Expect = 0.0
Identities = 806/2967 (27%), Positives = 1300/2967 (43%), Gaps = 297/2967 (10%)
Query: 453 NHAPLFNRSSYDGTL--DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPF-SIDP 509
N P F +D L E+ P G+SV + A D D N + + ++G +A F +++P
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEP 82
Query: 510 YLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNC 569
G++ +P+D E K +T SD R+ + +Q+ ++NDN P F
Sbjct: 83 DTGVVWLRQPLDRE-TKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPY 137
Query: 570 TGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLT 629
+ I ++ PVG I ++A D D ++F ++ G++++ R L
Sbjct: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIR---ELD 194
Query: 630 AGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGL 689
+Y L + A+D DKT L+ + +
Sbjct: 195 YETTQAYQLTVNATDQ-------------------------DKTRPLSTLANLAIIITDV 229
Query: 690 QNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGK 749
Q+ D F +L P S ++ E P T + + A D D G
Sbjct: 230 QDM---DPIFINL----------------PYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
Query: 750 LVYVIADGNEEGCFDIELETGLLTVAAPLDYE---ATNFYILNVTVYDLGTPQKSSWKLL 806
+ Y I GN F ++ +G+LT+ LD E ++ +IL V +L + S +
Sbjct: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
Query: 807 T----VNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI---AELTTKDADSEDNGRVR-YT 858
T + V D NDNAP F Y + I+E +VG + ++ KD + N Y
Sbjct: 331 TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
Query: 859 LLSPTEKFSLHPLTGE------LVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI 912
+ + + F + P + + + V LD E+ RY + A + SV D +
Sbjct: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE---------SVPDHV 441
Query: 913 ------ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD 966
ITL + NDN P + + E++ GT + + A+D D G GEV Y D
Sbjct: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
Query: 967 GAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNEN 1026
F +D TG ++L LD+E + L++ A DGG T V + VLDVN+N
Sbjct: 502 DP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDN 557
Query: 1027 LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF---SIN 1083
+ P F + G ++EN PS TQ++ + A D+DS + ++ Y + + + ++ S+
Sbjct: 558 V--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
Query: 1084 QDTGMIQTLAPLDREFAS--YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV 1141
+ G+I PLD E S +LTV+A+D G+ PL+S V IEV D NDNPP S+
Sbjct: 616 EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA 675
Query: 1142 FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLD 1201
++ S+ E+ G +VL L+A D D S + I S F I+ +G ++T LD
Sbjct: 676 YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLD 735
Query: 1202 RENKDEHILEVTVLDNGEPSLKSTSRVVVGI--LDVNDNPPIFSHKLFNVRLPERLSPVS 1259
RE K E+IL V +D G + T V I LD+NDN P + + + L E P S
Sbjct: 736 RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDS 795
Query: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGE--------- 1310
V +VA D D G NG + YSI+ + + +S++ TG + ++ E
Sbjct: 796 --DVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
Query: 1311 YNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDP----VNH 1366
+ + TD G+PPL A+ + ++ + F + V+E P +
Sbjct: 853 MRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
Query: 1367 MVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG- 1425
+V + EG GL + + G MDF I ++G +V LD R + Y L V +D
Sbjct: 912 VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG 971
Query: 1426 ----SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKG--K 1479
S T +H+ ++N P F Y V V +D ++ + D D G
Sbjct: 972 TPTKSSTSTLTIHVL---DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
Query: 1480 SLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
L Y I G G S+ D V+ TV LD + + + L + D KR+
Sbjct: 1029 ELSYFITGGNVDGKFSVGYRD---AVVRTVVGLDRET-TAAYMLILEAIDNGPVGKRHTG 1084
Query: 1540 WVTIHVE--DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG 1597
T+ V D N + P F Q YEASVP+ I G +LQ++A DAD G V Y +L G
Sbjct: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG 1144
Query: 1598 NSEGFFNINALLGIITLAQK-LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
N F I+ G++ + LD+ ++ H L V+A + VI++V +
Sbjct: 1145 NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE 1204
Query: 1657 APIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSG 1710
AP+F++ +Y + + E+ +G+ +++V A V Y + G +G F ++ +G
Sbjct: 1205 APVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTG 1263
Query: 1711 LISTQKKLDHEKISSYQLKIRGSNMAGAFTD--VMVVVDIIDENDNAPMFLKSTFVGQIS 1768
LI T LD+E +SY + + ++ A F V + +++E D A F +++
Sbjct: 1264 LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASY----- 1318
Query: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKI---LEPEALKFFKIDPSMGTLTIV 1825
EAA L ++ + ++ + + + Y+ +A FKID G +T+
Sbjct: 1319 EAAILENLALGTE----IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
Query: 1826 SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFS-EQIYEVAIVGP 1884
+D E + V D G V +V I V D ND+ PRF V+I
Sbjct: 1375 GLVDREKGDFYTLTVVADDGGPKV---DSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
Query: 1885 IHPGMELLMVRASDEDS----EVNYSIKTGN---ADEAVTIHPVTGSISVLNPAFLGLSR 1937
G + V+A D D+ +V +S+ +GN A E VT + G + V P L R
Sbjct: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP----LDR 1487
Query: 1938 K------LTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDV-YWAAVKENLQDRKAL 1987
+ L + ASD + ++++++ + D + Y +V EN+ A+
Sbjct: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
Query: 1988 VILGAQGNH--LNDTLSYFLLNGT-DM-FHMVQSAGVLQTRGVAFDREQQDTHELAVEVR 2043
V + A +N LSY++ G DM F M + +G + TR DRE+Q + L V
Sbjct: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
Query: 2044 DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEP-GDVLFQVSATDEDLGTN 2102
D TP A V V+I D NDN P F+ Y ++ +G + L + A D D G N
Sbjct: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
Query: 2103 GAVTYEFAED--YTYFRIDPYLGDISLKKPFDYQ-ALNKYHLKVIARDGG---TPSLQSE 2156
G VTY FRID ++G I+ K DY+ + +Y L V A D + L S
Sbjct: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTST 1727
Query: 2157 EEVLVTVR--NKSNPLF----QSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEE 2210
VLV V N + P F + P+ ++T + H + P G ++ Y+I++
Sbjct: 1728 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNG-QVEYSIMDG 1786
Query: 2211 EPLMLFTTDFKTGVLTVTG--PLDYESKTKHVFTVRATDTALGSFSEA-TVEVLVEDVND 2267
+PL F GVL V LD E+ + T+ A D + S V + V D+ND
Sbjct: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
Query: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGS 2327
N P L +ISE P + V +LASD DSG N +++ I + + F IN +
Sbjct: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE--RAFFINAT 1904
Query: 2328 TGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGE---TLVVVNVSDINDNPPEFRQPQY 2384
TG ++ + LD E + + + D + P L+++ +SD NDN P F + Y
Sbjct: 1905 TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTY 1964
Query: 2385 EANVSELATCGH----LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFN 2440
+A V E + G L + A+D D + + Y +L G Q F INSS+G++++ +
Sbjct: 1965 QAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRS 2023
Query: 2441 --LCKKHLDSS--YNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAM 2495
+ + S L + A D G+ +T + I + N P F L EN
Sbjct: 2024 GVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCP 2083
Query: 2496 VGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAI 2555
G V+ + A D+DSG G + Y I A ++F I+ + + + + +
Sbjct: 2084 PGFSVLQVTATDEDSGLNGELVYR-IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRL 2142
Query: 2556 KVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDAD 2613
V+A D G T V I++ D ND+ P+F TVS+ + + + + A D D
Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
Query: 2614 -----EGQNADVTYSVNPEDLV---KDVIEINPVTGVVKVKD----SLVGLENQTLDFFI 2661
E + + + LV +D +N TG V VK LV TL
Sbjct: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
Query: 2662 KAQDGGPPHWNSLVP---VRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIG-IVKAVA 2717
A D P + VP + + V+ + P+F +P E + EG+ G + AVA
Sbjct: 2263 NASD--LPERSVSVPNAKLTVNVLDVNDNTPQF-KPFGITYYMERILEGATPGTTLIAVA 2319
Query: 2718 AQDP--VIYSLVRGTTPESNKDGVFSL-DPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN 2774
A DP + LV T + G L D G + + +D+E V A +
Sbjct: 2320 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGS 2379
Query: 2775 TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSY 2834
+ + V +++ D+NDN P+F+ Y+ + E++PVGT ++ VTA D D+G + Y
Sbjct: 2380 PPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEY 2439
Query: 2835 RLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTI---QLSSQAL 2891
L + FAI+ +G I L LD E Y +A D+ + + +
Sbjct: 2440 SL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 2494
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
V + + D ND P+F+ ++ SV EN G V T+ D D N ++T Y EG
Sbjct: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNGELT-YSLEGPG 2552
Query: 2952 LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDN- 3007
+ F + D +++++ L + K+ L V A+DG + + + V+DVNDN
Sbjct: 2553 VEAFHVDM--DSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
Query: 3008 ----SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHE----FK 3059
P +L+ + E++ + +V ATD D N + YS + F
Sbjct: 2609 PVFVRPPNGTILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 2665
Query: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATDGG---GRSCQADITLHVEDVNDNAPRFF-- 3114
+DP +G + T LDRE + V++L+ A+D G + + +ED++DN P F
Sbjct: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
Query: 3115 ----PSHCAVAVFDNTTVKTPVA-VVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGV 3168
P + + V +++ T V V A D D+G NA V Y + + E +F + G
Sbjct: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGC 2784
Query: 3169 IRLEKPLQVRPQAPLELTVRASDLGT------PIPL------STLGTVTVSVVGLEDYLP 3216
+ + + L +A V+AS + P P TL V V + + D P
Sbjct: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATL 3243
F E++ V DA G+E++Q+ L
Sbjct: 2845 RFTKAEYTAGVATDAKVGSELIQVLAL 2871
Score = 680 bits (1755), Expect = 0.0
Identities = 743/2725 (27%), Positives = 1200/2725 (44%), Gaps = 230/2725 (8%)
Query: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFA 1100
+ E++P G+ V + AQD D+ L + + F++ DTG++ PLDRE
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 1101 SYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
S + + D V +V I+V D NDN P + I E+ PVGT + ++
Sbjct: 99 SEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
Query: 1161 AWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEP 1220
A DPD + G + ++ + FF I G+++ ++LD E + L V D +
Sbjct: 156 ATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
Query: 1221 SLKST-SRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLV-ASDLDEGLNGR 1278
ST + + + I DV D PIF + ++ + E SP PG R++ A D D+G
Sbjct: 214 RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH-SP--PGTTVRIITAIDQDKGRPRG 270
Query: 1279 VTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGE--YN---ILTIKATD--SGQPPLSASV 1330
+ Y+I + + F++D ++GV++ + Y+ ILT+K T+ + P A+V
Sbjct: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
Query: 1331 RLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNH----MVGVISVEGRPGL-FWFNIS 1385
+ + P F+ + YS + E V + V+ + GL F +
Sbjct: 331 TTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVY 389
Query: 1386 -GGDKDMDFDIEKTTGS------IVIARPLD--TRRRSNYNLTVEVTDGSRTIATQVHIF 1436
G+ F I T+ I +A PLD T R +++L + +V I
Sbjct: 390 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKIT 449
Query: 1437 MIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASL 1496
+I N N +RP F + Y + + ++ G +L V A D D G + S DP
Sbjct: 450 LI-NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
Query: 1497 FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ--EIPIKRNFVWVTIHVEDGNLHPPR 1554
F LD +G+++ + +LD + TLT++ RD E R V I+V D N + P
Sbjct: 506 FSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGR----VRINVLDVNDNVPT 560
Query: 1555 FTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEG-FFNINAL--LGI 1611
F + Y ++ + T+L+++RA D D N ++ YS++ ++ G +F+I+ G+
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 1612 ITLAQKLD--QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669
I++++ LD Q ++ LTV A D G+P + V I V+ + + P FSK YFV +
Sbjct: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
Query: 1670 PESIPVGSPILLVSAMS--------PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
E+I G+ +L ++A + Y L EG+ F +N+ SG I+T LD E
Sbjct: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLDRE 737
Query: 1722 KISSYQLKIR------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775
S Y L +R G N V + ++D NDN P + + + + E P
Sbjct: 738 TKSEYILIVRAVDGGVGHNQKTGIATVNIT--LLDINDNHPTWKDAPYYINLVEMTP--- 792
Query: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEM------- 1828
+++ + A D D N LVY I P KF+ ++ + G + M
Sbjct: 793 ----PDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPD 846
Query: 1829 DYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPG 1888
+E+ + V V D G P L A A V +++ D+ND+ P F + ++ I G
Sbjct: 847 PHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
Query: 1889 MELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLT 1940
+ + V A D D +N Y + G I+ +G V+ L R +L
Sbjct: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLR 964
Query: 1941 IRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNH- 1996
+ ASD T+ + I + V D++ F VY +V E++ +V L N
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
Query: 1997 -LNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQRV 2051
LN LSYF+ G F + V++T V DRE + L +E DN +
Sbjct: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTV-VGLDRETTAAYMLILEAIDNGPVGKRHT 1083
Query: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111
V V++ DVNDN P F Y + + G + Q+ ATD D G G V Y
Sbjct: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILH 1143
Query: 2112 DY--TYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NK 2166
FRI G + +P D + + + L V A + ++S V+V V N
Sbjct: 1144 GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
Query: 2167 SNPLF-QSPYYKVRVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKT 2222
P+F Q Y ++ + E + T ++ QA S +G + Y I+ F D T
Sbjct: 1204 EAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-FEIDEST 1262
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVN--DNPPTFSQLVYTTS 2280
G++ LDYE+KT ++ V ATD A F++ V + +N D FS Y +
Sbjct: 1263 GLIITVNYLDYETKTSYMMNVSATDQA-PPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
Query: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK-FFQINGSTGEMSTVQELDY 2339
I E L T ++++ A D+ ++Y+ S +K F+I+ TG + TVQ L
Sbjct: 1322 ILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI-TVQGLVD 1378
Query: 2340 EAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEA-NVSELATCGHLV 2398
+ F+ D G P + V + V D NDN P F A ++ E G V
Sbjct: 1379 REKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV 1438
Query: 2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFI---NSSSGIISMFNLCKKHLDSSYNLRVG 2455
V+A DPD+ ++ + + SGN F I N S G + + + Y L+V
Sbjct: 1439 ATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1498
Query: 2456 ASDGVFRATVP------VYINTTNANKYSPEFQQHL-YEAELAENAMVGTKVIDLLAIDK 2508
ASD R T P + + + N P + Y + EN GT V+ + A D+
Sbjct: 1499 ASD---RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
Query: 2509 DSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKL-DRENSTERVIAIKVMARDGGGRV 2566
D G + Y I F ++ +G+IAT DRE + + V
Sbjct: 1556 DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS 1615
Query: 2567 AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSK-DSPVIQVLAYDADEGQNADVTYSVN 2625
A V + + DENDN P F+ Y V + ++ +I + A D DEG N VTY++
Sbjct: 1616 ATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675
Query: 2626 PEDLVKDVIEINPVTGVVKVKDSL-VGLENQTLDFFIKAQDGGP---PHWNSLVPVRLQV 2681
++V + I+ GV+ L + + + A D P S V + V
Sbjct: 1676 AGNIV-NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNV 1734
Query: 2682 VPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD-------PVIYSLVRGTTPES 2734
++P F + P ++ EG V A D V YS++ G
Sbjct: 1735 NDINDNVPTFPRD---YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDG----- 1786
Query: 2735 NKDGVFSLDPDTGVIKVRKP--MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
+ G F + P GV++VRK +D E+ Y + + A + S + V I+V D+ND
Sbjct: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
Query: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDS 2852
N PV P ++EN PV + V V A D D+G + ++++ ++A N F I++
Sbjct: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITA---GNRERAFFINA 1903
Query: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQA--LVQVSITDENDNAPRFASEE 2910
+G +T + LD E Y + D+ + +++ + L+ + ++DENDN P F
Sbjct: 1904 TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
Query: 2911 YRGSVVENSEPGELVATLK----TLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRI 2966
Y+ V+ENS G + L LDAD + V Y G G F I+ +
Sbjct: 1964 YQAEVMENSPAGTPLTVLNGPILALDAD--QDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2021
Query: 2967 SSRKTLDREHTAKYLLRVT--ASD-GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHED 3023
S +DRE + +L + A D G ++ + I +LD NDN P S T + E+
Sbjct: 2022 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLEN 2081
Query: 3024 VFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTA-LDRERKDVFN 3082
PG +L+V+ATD D+ N ++ Y + F + TG + A +DRE ++ +
Sbjct: 2082 CPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYR 2141
Query: 3083 LVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDP 3140
L ATD G S A +T+ ++D+ND+ P F V+V ++ T +A + A D
Sbjct: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201
Query: 3141 DQGANAQVVYS------------LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
D N ++ Y L + E F+++ TG + ++ P+ A E+T+
Sbjct: 2202 D--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
Query: 3189 ASDLGTPIPLSTLGT----VTVSVVGLEDYLPVFLN---TEHSVQVPEDAPPGTEVLQLA 3241
D + +P ++ +TV+V+ + D P F T + ++ E A PGT ++ +A
Sbjct: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
Query: 3242 TLTRPGAEKTG---YRVVSGNEQGRFRL-DARTGILYVNASLDFETSPKYFLSIECSRKS 3297
+ P G Y ++ G +L D+ G + N ++D+E ++ S
Sbjct: 2320 AVD-PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNG 2378
Query: 3298 SSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDIT 3357
S + V + I D+N++ P F Q Y V E+ VG +ILTV+ATD D + I
Sbjct: 2379 SPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIE 2438
Query: 3358 YSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDS----GQPPLHEDTDIA 3413
YSL G+ F I+P G++ V +LDRE+ Y L A D+ +
Sbjct: 2439 YSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVV 2496
Query: 3414 IQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGP-PYSFRITKGNNG 3472
IQV DVND P+F + +ST+V EN P G+ V+ ++ +D D NG YS +G
Sbjct: 2497 IQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL---EGPGV 2553
Query: 3473 SAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSAL 3532
AF V D LVT + ++ E + L + A+D G PPL T + V V + + P +
Sbjct: 2554 EAFHVDMDSGLVTTQ-RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
Query: 3533 --PLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRH----FSVGAPD 3584
P + + E+ V +++ATD+D + YS +T G F +
Sbjct: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL--KTAGNRDWEFFIIDPIS 2670
Query: 3585 GKIIAAQGLPR---GHYSFNVTVSD 3606
G I AQ L R YS + SD
Sbjct: 2671 GLIQTAQRLDRESQAVYSLILVASD 2695
Score = 607 bits (1565), Expect = e-173
Identities = 561/1939 (28%), Positives = 870/1939 (44%), Gaps = 144/1939 (7%)
Query: 1666 FVEIPESIPVGSPI--LLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI 1723
++ I E PVGS + LL M + + + F++ +G++ ++ LD E
Sbjct: 39 YLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 1724 SSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN 1783
S + ++ S+ G T V + + D NDNAP F + +I E P+ + I
Sbjct: 99 SEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI------ 151
Query: 1784 PFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVH 1843
F+++A+D D A ++Y P +FF ID + G +T++ E+DYE+ ++Q V
Sbjct: 152 -FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 1844 DQGSPVLFAPRP----AQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899
DQ RP A + I + DV D P F Y I PG + ++ A D+
Sbjct: 209 DQDKT-----RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
Query: 1900 DSE----VNYSIKTGNADEAVTIHPVTGSISVL------NPAFLG---LSRKLTIRASDG 1946
D + Y+I +GN + + ++G +++ NP + L+ K T D
Sbjct: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
Query: 1947 LYQD---TALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL-----VILGAQGNHLN 1998
D T I + + D + +F+ Y A+ E Q AL V+ + LN
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
Query: 1999 DTLSYFLLNGTDMFHMVQSAGVLQTRG-------VAFDREQQDTHELAVEVRDNRTPQRV 2051
+L+ G + H + S +Q + + D E D ++ + ++ P V
Sbjct: 384 SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
Query: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111
V++++ + NDN P F Y + + G + V ATD D GT G V+Y F++
Sbjct: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
Query: 2112 DYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLF 2171
D F +D G I L DY+ + ++ L +IARDGG + V N + P F
Sbjct: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
Query: 2172 QSPYYKVRVPEN---ITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKT------ 2222
Q Y + EN +T + T SP ++ Y+IV F + F
Sbjct: 562 QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS---AFGSYFDISLYEGY 618
Query: 2223 GVLTVTGPLDYESKTKHV--FTVRATDTA---LGSFSEATVEVLVEDVNDNPPTFSQLVY 2277
GV++V+ PLDYE + + TV A D L S T+EV D NDNPPTFS+ Y
Sbjct: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF--DENDNPPTFSKPAY 676
Query: 2278 TTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQEL 2337
S+ E + A V+ L A+D D R+R+ + + + S F+IN +GE++T L
Sbjct: 677 FVSVVENIMAGATVLFLNATDLD--RSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
Query: 2338 DYEAQQHFHVKVRAMD--KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
D E + + + VRA+D G TG V + + DINDN P ++ Y N+ E+
Sbjct: 735 DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
Query: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG-------IISMFNLCKKHLDS 2448
V V A+DPD + L Y I N + + +NS++G ++ N +
Sbjct: 795 SDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
Query: 2449 SYNLRVGASD---GVFRAT--VPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL 2503
+ V +D +AT V++N + N P FQ + AE+ E G + +
Sbjct: 853 MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
Query: 2504 LAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDG 2562
+AID D G G + Y + + F IN +G + T +LDRE E ++V+A D
Sbjct: 913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE--YQLRVVASDA 970
Query: 2563 G--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADV 2620
G + + T+ I + D ND P F + Y VS+ +V ++ V+ + D D G NA++
Sbjct: 971 GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
Query: 2621 TYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFF---IKAQDGGP--PHWNSLV 2675
+Y + + V + VV+ ++VGL+ +T + ++A D GP
Sbjct: 1031 SYFITGGN-VDGKFSVGYRDAVVR---TVVGLDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
Query: 2676 PVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTT 2731
V + V+ + P F + Y S PED+PEG I +KA A + V Y ++ G
Sbjct: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-- 1144
Query: 2732 PESNKDGVFSLDPDTGVI-KVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDV 2790
N F + G++ + +P+D E + + V A+ + S V V + V D+
Sbjct: 1145 ---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
Query: 2791 NDNRPVFEADPYKAV-LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFA 2849
ND PVF Y + L E +GTSVI V A D+D+G G V+YR+ S F
Sbjct: 1202 NDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL----SGAEGKFE 1257
Query: 2850 IDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASE 2909
ID +G I T+ LD ET +Y +V A D V +++ +E D A +F++
Sbjct: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNA 1316
Query: 2910 EYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSR 2969
Y +++EN G + ++ D Q T F I + I+ +
Sbjct: 1317 SYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV--ITVQ 1374
Query: 2970 KTLDREHTAKYLLRVTASDG--KFQASVTVEIFVLDVNDNSPQCSQLLYTG-KVHEDVFP 3026
+DRE Y L V A DG K ++V V I VLD NDNSP+ + + ED
Sbjct: 1375 GLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPV 1434
Query: 3027 GHFILKVSATDLDTDTNAQITYSLHG---PGAHEF-KLDPHTGELTTLTALDRERKDVFN 3082
G + V A D D +N Q+ +SL GA E + GE+ LDRE D +
Sbjct: 1435 GQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYI 1494
Query: 3083 LVAKATDGGGRSCQADITLHVE--DVNDNAPRF-FPSHCAVAVFDNTTVKTPVAVVFARD 3139
L A+D G + D L V D+NDN P P V+V +N T V V A D
Sbjct: 1495 LQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATD 1554
Query: 3140 PDQGANAQVVYSLPD-SAEGHFSIDATTGVIRLE-KPLQVRPQAPLELTVRASDLGTPIP 3197
D G N+ + Y + + + + F +D +G I P Q+ L D GTP
Sbjct: 1555 RDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP-T 1613
Query: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSV---QVPEDAPPGTEVLQLATLTRPGAEKTGYR 3254
LS V V++V D P+F + V + P+ +Q L Y
Sbjct: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
Query: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETS-PKYFLSIECSRKS---SSSLSDVTTVMVN 3310
+V+GN FR+D G++ LD+E S +Y L + + + S L+ TTV+VN
Sbjct: 1674 IVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVN 1733
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D+N++ P FP+D + G + T A D D N + YS++ G+ LG F
Sbjct: 1734 VNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
Query: 3371 IHPKKGELQVAK--ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQ 3428
I P +G L+V K LDRE + Y+L + A D G PPL + I+V D+NDN P
Sbjct: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
Query: 3429 LNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA-E 3487
L + T+ ENSP+ S V ++ SD DS N +F IT GN AF + +VT
Sbjct: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAFFINATTGIVTVNR 1912
Query: 3488 GLSRRAQEWYQLQIQASDS 3506
L R Y+L I D+
Sbjct: 1913 PLDRERIPEYKLTISVKDN 1931
Score = 305 bits (782), Expect = 5e-82
Identities = 331/1204 (27%), Positives = 516/1204 (42%), Gaps = 83/1204 (6%)
Query: 2479 PEFQQHLYEAEL--AENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQ 2536
P F H ++ L +E+ VG+ V LLA D D+ P + + + + AS F++ P+
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
Query: 2537 IATL-QKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQ 2595
+ L Q LDRE +E + V G V V I + D NDN P F Y+V I
Sbjct: 86 VVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
Query: 2596 SNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ 2655
N +P+ V A D D G V YS P I+ G+V V L Q
Sbjct: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQ 199
Query: 2656 TLDFFIKAQDGGPPH-WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVK 2714
+ A D ++L + + + + P F Y+ + E P G+ + I+
Sbjct: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Query: 2715 AVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQ----IDVMAH 2770
A+ QD + T N + +F+LD +GV+ + +D E+ LY + V
Sbjct: 260 AID-QDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGT 317
Query: 2771 CLQN----TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV-IQVTAIDKD 2825
L + +D + NI V D+NDN P F + Y +TE VG ++ + + +DKD
Sbjct: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
Query: 2826 TGRDGQVSYRLSADPGSNVHELFAIDSESGW----ITTLQELDCETCQTYHFHVVAYDHG 2881
+ + ++ H + + S G I LD ET Y F + A +
Sbjct: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-- 435
Query: 2882 QTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQ 2941
A V++++ +ENDN P F+ Y S+ EN G V T+ D D
Sbjct: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE- 494
Query: 2942 VTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASV-TVEIF 3000
Y DP +F + + D I LD E ++ L + A DG + + V I
Sbjct: 495 -VSYFFSDDP-DRFSLDK--DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
Query: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAH---- 3056
VLDVNDN P + Y G + E+ ++++ ATD D+ N QITYS+ A
Sbjct: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
Query: 3057 EFKLDPHTGELTTLTALDRER--KDVFNLVAKATDGGGRSCQADI--TLHVEDVNDNAPR 3112
+ L G ++ LD E+ + L A D G + + T+ V D NDN P
Sbjct: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
Query: 3113 FFPSHCAVAVFDNTTVKTPVAVVFARDPDQG---ANAQVVYSLPDSAEGHFSIDATTGVI 3169
F V+V +N V + A D D+ ++YSL S + F I+A +G I
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEI 728
Query: 3170 RLEKPLQVRPQAPLELTVRASDLGTPIPLST-LGTVTVSVVGLEDYLPVFLNTEHSVQVP 3228
L ++ L VRA D G T + TV ++++ + D P + + + + +
Sbjct: 729 TTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLV 788
Query: 3229 EDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRF-RLDARTG-ILYVNASLDFETSPK 3286
E PP ++V + + P + G V S +F L++ TG I +A LD E
Sbjct: 789 EMTPPDSDVTTVVAVD-PDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
Query: 3287 YFLSIECSRKSSSSLSDV----------TTVMVNITDVNEHRPQFPQDPYSTRVLENALV 3336
+ E RK S++D TV VN+ D+N++ P F P+ VLE
Sbjct: 848 H--EAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
Query: 3337 GDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKL 3396
G I V A D D LN ++Y + G F I+ G + LDRE+ + Y L++
Sbjct: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
Query: 3397 RATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSP 3456
A+D+G P + + I V DVND P FF Y+ +V E+ P +V+ L +D D
Sbjct: 966 VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG 1025
Query: 3457 ENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL---- 3511
N S+ IT GN F V D + T GL R Y L ++A D+G P+
Sbjct: 1026 LNA-ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG--PVGKRH 1082
Query: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD--TLTYSLA 3569
+ +V V V + + P L +V ED +G + ++ ATD D + + Y +
Sbjct: 1083 TGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
Query: 3570 EEETLGRHFSVGAPDGKII-AAQGLPRGHYSFNVTVSD------GTFTTTAGVHVYVWHV 3622
G +F + +G ++ + L R S +V + + G ++ V VYV +
Sbjct: 1143 HGNH-GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
Query: 3623 GQEA 3626
EA
Sbjct: 1202 NDEA 1205
Score = 109 bits (272), Expect = 7e-23
Identities = 141/586 (24%), Positives = 237/586 (40%), Gaps = 78/586 (13%)
Query: 134 VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM 193
V + I+D ND P+F PSY+ + ED+P+ + I VTATDAD G A Y+
Sbjct: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
Query: 194 FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE-----P 248
FAI+PT+G + V L+ + + L LA D ++ S+ ++ ++ P
Sbjct: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
Query: 249 ALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYAR 308
KP SV P GT+ T++ G E + G PG ++++
Sbjct: 2508 QFSKPQFSTSVYENEPA---GTSVITMMATDQDEGPNGELTYSLEG-PG-----VEAFHV 2558
Query: 309 SNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYR 368
+ LV+ + ++ F+L++ A G P + G + ++ + + V+
Sbjct: 2559 DMDSGLVTTQ--RPLQSYEKFSLTVVATDGGEPPLW----GTTMLLVEVIDVNDNRPVFV 2612
Query: 369 -------VQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG-------FKLNARTGL 414
+ + E P S V V T L ++ S F ++ +GL
Sbjct: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
Query: 415 ITTTKLMDFHDRAHYQLHIRTS------PGQASTVVVIDIVDCNNHAPLFNRSSYDG--- 465
I T + +D +A Y L + S P + + + + D +++ PLF R
Sbjct: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
Query: 466 ---TLDENIPPGTSVLAVT-ATDRDHGENGYVTYSIA-GPKALPFSIDPYLGIISTSKPM 520
T+ E+ P GT V VT A D D G N V Y IA G + F + P G + + +
Sbjct: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDL 2791
Query: 521 DYELMKRIYTFRVRASD---WGSPFRREKEVSIFLQL---------RNLNDNQPMFEEVN 568
D E + I++F V+AS W P + + L ++ND P F +
Sbjct: 2792 DRE-REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850
Query: 569 CTGSIRQDWPVGKSIMTMSAIDVDELQN---------LKYEIVSGNELE----YFDLNHF 615
T + D VG ++ + A+D D N + Y N+ E F +
Sbjct: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSM 2910
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKD 661
G++ R F A P + + I A D + + I +++D
Sbjct: 2911 DGIL---RTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRD 2953
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 802 bits (2072), Expect = 0.0
Identities = 768/2772 (27%), Positives = 1204/2772 (43%), Gaps = 206/2772 (7%)
Query: 932 LKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLM----DGAHGTFRVDLMTGALILEREL 987
L++ E+ P GT++ + A P G A + Y + G +D +G + R L
Sbjct: 49 LQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
Query: 988 DFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPS 1047
D E+R Y + DG V V V D+N+ H P F QV E++
Sbjct: 108 DREQRDRYRFTAVTPDGAT-------VEVTVRVADIND--HAPAFPQARAALQVPEHTAF 158
Query: 1048 GTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP-------LDREFA 1100
GT+ + A+D D+G G Y L F + G T P LDRE
Sbjct: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
Query: 1101 SYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
S+Y L + A D GS P + + + + D ND+ P +Q+ ++ + E G+ VLQ+
Sbjct: 219 SHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVF 278
Query: 1161 AWDPDSSSKGKLTFNITSGNYMGF--FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNG 1218
A D D+ G +T+ I G F I TGLL + LD E + H L V D G
Sbjct: 279 ASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGG 338
Query: 1219 EPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP--VYRLVASDLDEGLN 1276
++ V V + D NDN P + + ++S +P V R+ SD D+G
Sbjct: 339 AHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF 398
Query: 1277 GRVTYSIEDSDEEAFSI---DLVTGVVSSSSTFTAGE---YNILTIKATDSGQPPLSASV 1330
V S+E E F++ D V +V + E YN L + ATDSG PPL A
Sbjct: 399 AHVNVSLEGG-EGHFALSTQDSVIYLVCVARRLDREERDAYN-LRVTATDSGSPPLRAEA 456
Query: 1331 R--LHIEWIPWPRPSSIPLAFDETYYSFTVMETD--PVNHMVGVISVE---GRPGLFWFN 1383
LH+ + P AFD Y + P + +V V + + G G ++
Sbjct: 457 AFVLHVTDVNDNAP-----AFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS 511
Query: 1384 ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT-IATQVHIFM-IANI 1441
++ G F I+ T+G I A LD L V TDG +A+ + + + ++
Sbjct: 512 LAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV 571
Query: 1442 NHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQL 1499
N + PQF T Y +P+ T PG L+V A D D G L Y++ + F++
Sbjct: 572 NDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI 631
Query: 1500 DPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLH 1559
D SG + T LD GPS TV D ++ V+V + + D N +PP+F
Sbjct: 632 DAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPRE 689
Query: 1560 YEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
Y AS+ PGT +L++RA D D+G + + Y +L GNS F ++ G++T+A L
Sbjct: 690 YAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLA 749
Query: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
+ ++ L + AED G Q A V I + P + PIF + +Y +PE + G+ +
Sbjct: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSV 809
Query: 1680 LLVSAMSP----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISS-YQLKIR-GS 1733
+V A +P + VT L G+ G+FS+++ SGL+ T + LD E + +L++R GS
Sbjct: 810 GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGS 869
Query: 1734 NMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP----FVIHA 1789
+ AF V V + D NDN+P F AP ++++ N P + + A
Sbjct: 870 GVPPAFAVARVRVLLDDVNDNSPAF-----------PAPEDTVLLPPNTAPGTPIYTLRA 918
Query: 1790 SDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPV 1849
D D NS + + +L F +DP+ G + ++ + P+ + + D GSP
Sbjct: 919 LDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPP 977
Query: 1850 LFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED-SEVNYSIK 1908
+ +V++ PRF+ Y V + G ++L V+A D + Y +
Sbjct: 978 RTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLA 1037
Query: 1909 TGNADEAVTIHPVTGSISVLNPAFLGLSRKLTI---------RASDGLYQDTALVKISLT 1959
A + P +G + V A +++L I +A G TA V++S+
Sbjct: 1038 AEGASSPFGLEPQSGWLWV-RAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSIL 1096
Query: 1960 QVLDKSLQFDQDVYWAAVKENLQDRKAL--VILGAQGNHLNDTLSYF---LLNGTDMFHM 2014
+ S + +D + AV EN ++ V + + N L+Y L + F +
Sbjct: 1097 NQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRI 1156
Query: 2015 VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKH-- 2072
G + T DREQQ +++L V+V+D +P R G V V++ D+NDN P F
Sbjct: 1157 HPQTGEVTTL-QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQAS 1215
Query: 2073 ------LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-AEDYTYFRIDPYLGDI 2125
LP + D PG ++ + A D D G NG + Y F + P+ G++
Sbjct: 1216 GAAGGGLPIQ--VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
Query: 2126 SLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENIT 2185
P Y L + A D G+P + ++LV V + P R P
Sbjct: 1274 LTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDP---A 1330
Query: 2186 LYTPILHTQARSPEGLR------------------LIYNIV-EEEPLMLFTTDFKTGVLT 2226
P++ T + EGLR L Y +V +P F D +G L
Sbjct: 1331 APVPVVLT-VTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLY 1389
Query: 2227 VTGPLDYESKTK-HVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGL 2285
+ PLD+E+ TVRA V+V V+D N++ P F++ ++ E
Sbjct: 1390 LARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENP 1449
Query: 2286 PAQTPVIQLLASDQDS-GRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQH 2344
+ ASD D G N DV Y+++ V +++ TG +S + LD E
Sbjct: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPA-LRLDARTGALSAPRGLDRETTPA 1508
Query: 2345 FHVKVRAMDK---GDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV 2401
+ V A D+ V V+D NDN P F P + E G L V
Sbjct: 1509 LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHV 1567
Query: 2402 QAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD--- 2458
A DPD + +R+ Y + SG D HF ++SS+G +S+ + + + L V ASD
Sbjct: 1568 VARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGS 1626
Query: 2459 GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDY 2518
AT + ++ + N +P FQQ Y L EN GT ++ L A D D G G + Y
Sbjct: 1627 PPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY 1686
Query: 2519 TIINKLASEKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTD 2577
++SE FS++P+ G + TL+ LDRE E + + R ++ TV++ + D
Sbjct: 1687 ---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVED 1743
Query: 2578 ENDNPPQFKASEYTVSIQSNVSKDSPVIQVL-AYDADEGQNADVTYSVNPEDLVKDVIEI 2636
END+ P F ++ +S++ +D + +L A D D G N + Y + D +
Sbjct: 1744 ENDHAPTFGSAH--LSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGD-PSGAFVL 1800
Query: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLY 2696
+ +G L I+A+DGG P ++ + + + V+ P F P Y
Sbjct: 1801 DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1860
Query: 2697 TFSAPEDLPEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
+ PED+P G+ ++ + A DP V Y L GT G F L+P +G +
Sbjct: 1861 SVEVPEDVPAGT---LLLQLQAHDPDAGANGHVTYYLGAGTA------GAFLLEPSSGEL 1911
Query: 2750 KVRKPMDHESTKLYQIDVMA-HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTE 2808
+ +D E Y V A + + VSV I V DVND+ P F P + L
Sbjct: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
Query: 2809 NMPVGT----SVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELD 2864
P + ++ + A D+D G + + YRL+ P +DS +G I +
Sbjct: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT----TVDSYTGEIRVARSPV 2027
Query: 2865 CETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGEL 2924
+ +VA D G+ + S+ ++ V + E + PRF ++ EN+ PG
Sbjct: 2028 ALGPRDRVLFIVATDLGRPAR-SATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTP 2086
Query: 2925 VATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRV 2984
+ + + + A N +T I G+ G F I + S + LD E + + L +
Sbjct: 2087 IVSPRAVHA--GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL 2144
Query: 2985 TASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNA 3044
A G A + + + D NDN+P+ + Y + E +L+V A DLD +
Sbjct: 2145 QAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGG 2204
Query: 3045 QITYSLHG--PGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSC--QADIT 3100
QI+YSL P F +DP TG +TT LDRE LV ATD G + A +T
Sbjct: 2205 QISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLT 2264
Query: 3101 LHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHF 3160
+ V D NDN P P + V ++ + + +A V D D G V S P + F
Sbjct: 2265 VMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLS-PSGPQDPF 2322
Query: 3161 SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
S+ G + L PL +L + A D P +TV V + D P F
Sbjct: 2323 SVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----GPHEGRANLTVLVEDVNDNAPAFSQ 2378
Query: 3221 TEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYV---NA 3277
+ + V + E PPG+ +L ++ R + F +D G L+
Sbjct: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTV 2438
Query: 3278 SLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVG 3337
+L + S + +E + + TV V + D N+H P F Y V E+ G
Sbjct: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
Query: 3338 DVILTVSATDEDGP-LNSDITYSLIGGNQLGHFTIHPKKGE--------------LQVAK 3382
+LT+ ATD DG ++ + YS+I GN F + P+ E L + +
Sbjct: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
Query: 3383 ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIG 3442
LD E + Y+L + A D GQPP + + V DVNDNPP F + +Y TV E++P+G
Sbjct: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
Query: 3443 SKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQI 3501
+++L + SD D +G F ++ G+ F + G L A L Q +QL +
Sbjct: 2619 AELLHVEASDADPGPHG-LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVV 2677
Query: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFIT-VGEDEFQGGMVGKIHATDRDP 3560
QA+D +L V + V + + + P A PL + T V E++ G +V +HA D D
Sbjct: 2678 QAADPAGAHF-ALAPVTIEVQDVNDHGP-AFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
Query: 3561 Q--DTLTYSLAE 3570
L YSL E
Sbjct: 2736 GAFGRLRYSLLE 2747
Score = 775 bits (2001), Expect = 0.0
Identities = 822/2986 (27%), Positives = 1295/2986 (43%), Gaps = 260/2986 (8%)
Query: 369 VQLSEFSPPGSRVVMVRVT----PAFPNLQYVLKPSSENVGFKL--NARTGLITTTKLMD 422
+Q+ E P G+ + + A P + ++ VG L + +G++ T +++D
Sbjct: 49 LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLD 108
Query: 423 FHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
R Y+ T G A+ V + + D N+HAP F ++ + E+ GT A
Sbjct: 109 REQRDRYRFTAVTPDG-ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPA 167
Query: 483 TDRDHGENGYVTYSIAGPKA-LPFSIDPYLGIISTSKP-------MDYELMKRIYTFRVR 534
D D G G Y+++G A F ++ G T P +D E + Y ++
Sbjct: 168 RDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRE-NRSHYMLQLE 226
Query: 535 ASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDEL 594
A D GSP RR + + + + L ++ND+ P F + + + G ++ + A D D
Sbjct: 227 AYDGGSPPRRAQAL-LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAG 285
Query: 595 QN--LKYEIVSGNELE---YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYA 649
N + YEI + + E F ++ +G++ L+RP L Q + L + A DG +
Sbjct: 286 VNGAVTYEI-NRRQSEGDGPFSIDAHTGLLQLERP---LDFEQRRVHELVVQARDGGAHP 341
Query: 650 SPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQIN 708
+ +TV V+D + NQ S F S
Sbjct: 342 ELGSAFVTVHVRDAN--------------------------DNQPSMTVIFLS------- 368
Query: 709 HYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELE 768
D PQ V E+ P +AR++ +DPD G + + G EG F + +
Sbjct: 369 ------ADGSPQ---VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQ 417
Query: 769 TG---LLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825
L+ VA LD E + Y L VT D G+P + ++V D NDNAP F Y
Sbjct: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
Query: 826 Q-LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLD 882
+ + E G+ + +T +D D NG+V Y+L + T FS+ P +G + LD
Sbjct: 478 RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLD 537
Query: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942
E EP+ L V A D L S + + L+DVNDN PQ +PE PGT
Sbjct: 538 YELEPQPQLIVVATDGGLP--PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGT 595
Query: 943 VLTFLDASDPDLGPAGEVRYVLMDGAHGT----FRVDLMTGALILERELDFER-RAGYNL 997
+ A+D D GP G + Y L G + FR+D +G + R LD ++ + ++
Sbjct: 596 CFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF 655
Query: 998 SLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQ 1057
++ A DGG +++ +V+V + D N+N PP F + + SP GT V+ + A
Sbjct: 656 TVTAVDGG---GLKSMVYVKVFLSDENDN--PPQFYPREYAASISAQSPPGTAVLRLRAH 710
Query: 1058 DDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL 1117
D D G G L Y + AG F++++ +G++ PL R S L + A D G +
Sbjct: 711 DPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQA 770
Query: 1118 SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT 1177
V I + PP Q + S+ ED GTSV + A +P +T +++
Sbjct: 771 EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP-PGRLAPVTLSLS 829
Query: 1178 SGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LDNGEPSLKSTSRVVVGILDVN 1236
G+ G F + V+GLL T + LDRE +LE+ V +G P + +RV V + DVN
Sbjct: 830 GGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEVRAGSGVPPAFAVARVRVLLDDVN 888
Query: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLV 1296
DN P F V LP +P + P+Y L A D D G+N RVT+++ AF++D
Sbjct: 889 DNSPAFPAPEDTVLLPPNTAPGT--PIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPT 946
Query: 1297 TGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
TG V + G + L ++A D G PP ++ RL + P TY
Sbjct: 947 TGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYR 1006
Query: 1355 SFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRS 1414
T ++ V + G ++++ F +E +G + + LD +
Sbjct: 1007 VDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQE 1066
Query: 1415 NYNLTVEVTDGSRT-----IATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
Y L V GS+ T I N N H P+ E + V ++ PG + R
Sbjct: 1067 LYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR 1126
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
V A D+D G + T Q + F++ P +G + T+ LD S + L V V+D
Sbjct: 1127 VFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD-REQQSSYQLLVQVQD 1185
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEA------SVPDTIAPGTELLQVRAMDAD 1583
P + V + V D N + P F Q A VPD + PGT + ++A D D
Sbjct: 1186 GGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPD 1245
Query: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDL 1643
G N + Y+L SE F+++ G + A L +A + LT+ A DQGSP
Sbjct: 1246 EGENGTILYTLTGPGSE-LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSAS 1304
Query: 1644 ATVIIHVYPSDRSA---PIFSKSEYFVEIP--------ESIPVGSPILLVSAMSPSEV-- 1690
+++ V PS R A P ++ + +P E + GS + V+A P+ V
Sbjct: 1305 LQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGA 1364
Query: 1691 -TYELREG-NKDGVFSMNSYSGLISTQKKLDHEKISSYQ-LKIRGSNMAGAFTDVM-VVV 1746
TY L G + +G F++++ SG + + LD E ++ L +R GA ++ V V
Sbjct: 1365 LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQV 1424
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP----FVIHASDSDKEA-NSLLV 1801
+ DEN++AP F + PL ++ + +N P + ASD+D NS +
Sbjct: 1425 QVQDENEHAPAFARD----------PL-ALALPENPEPGAALYTFRASDADGPGPNSDVR 1473
Query: 1802 YKILEPE-ALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVI- 1859
Y++L E + ++D G L+ +D E+ P+ V D+ P + R A +
Sbjct: 1474 YRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR--PANASRRRAARVS 1531
Query: 1860 --IHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNAD 1913
+ V D ND+ P F+ V + PG L V A D D + V+Y + +G D
Sbjct: 1532 ARVFVTDENDNAPVFASP-SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG-GD 1589
Query: 1914 EAVTIHPVTGSISVLNPAFLGLSRK------LTIRASD---GLYQDTALVKISLTQVLDK 1964
+H TG++SV+ P L R+ LT+ ASD T ++ +S+ V D+
Sbjct: 1590 GHFRLHSSTGALSVVRP----LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDE 1645
Query: 1965 SLQFDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYFLLNGTDMFHMVQSAGVLQ 2022
+ F Q Y ++EN +L+ L A + N ++Y ++ ++ F + GVL
Sbjct: 1646 APTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS-SESFSLDPDTGVLT 1704
Query: 2023 TRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDG 2082
T A DRE+Q+ L V +D +P ++ VRV++ED ND+ P F + +G
Sbjct: 1705 TLR-ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEG 1763
Query: 2083 TEPGDVLFQVSATDEDLGTNGAVTYEF--AEDYTYFRIDPYLGDISLKKPFDYQALNKYH 2140
+P L + A+D D+G NG + Y + F +D G+ +P D + +
Sbjct: 1764 QDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQ 1822
Query: 2141 LKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSP 2198
L++ ARDGG P+L + + VTV N P F P Y V VPE++ T +L QA P
Sbjct: 1823 LRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP 1882
Query: 2199 E--GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA 2256
+ + + F + +G L LD E + F+V A D A
Sbjct: 1883 DAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLST 1942
Query: 2257 TVEV--LVEDVNDNPPTFSQLVYTTSISEGLPA-QTPVIQLL---ASDQDSGRNRDVSYQ 2310
TV V V DVND+ PTF + P+ TP + L A D+D+G N + Y+
Sbjct: 1943 TVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
Query: 2311 IV---EDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVV 2367
+ G+ V + TGE+ + + + + A D G P + +++V
Sbjct: 2003 LAGTPPPGTTVDSY------TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIV 2056
Query: 2368 NVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHF 2427
+ + P F + EA + E A G ++ +A+ + + Y ILSGN+ F
Sbjct: 2057 GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTN-GPITYSILSGNEKGTF 2115
Query: 2428 FINSSSGIISMFNLCKKHLDSSYNLRV---GASDGVFRATVPVYINTTNANKYSPEFQQH 2484
I S+G I++ + + S LR+ S G F TV + + +AN +P F +
Sbjct: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV-LTLTLQDANDNAPRFLRP 2174
Query: 2485 LYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI-INKLASEKFSINP-NGQIATLQK 2542
Y A L E+ + ++ + A D D G G I Y++ ++ A F ++P G I T
Sbjct: 2175 HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAI 2234
Query: 2543 LDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDS 2602
LDRE E + + R V T+ +++ D NDN P + + + + S
Sbjct: 2235 LDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGS 2293
Query: 2603 PVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIK 2662
+ QV D D G V + V +D + G V + L + +
Sbjct: 2294 EIAQVTGNDVDSG---PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350
Query: 2663 AQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AA 2718
A DG PH + + V + P FS+ LY E P GS I V A A
Sbjct: 2351 AHDG--PH-EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGA 2407
Query: 2719 QDPVIYSLVRGTTPESNKDGVFSLDPDTG---VIKVRKPMDHESTKLYQIDVMAHCLQNT 2775
+ Y L S DG FS+DP+ G I + H+ + + + A
Sbjct: 2408 NGHISYHLA------SPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
Query: 2776 DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD-GQVSY 2834
+ +V++Q+ D ND+ P F Y+ +TE++P G++++ + A D D R V Y
Sbjct: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
Query: 2835 RLSADPGSNVHEL---FAIDSES--------GWITTLQELDCETCQTYHFHVVAYDHGQT 2883
+ + V +L A ES G + L+ LD E+ Y+ V A D GQ
Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
Query: 2884 IQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVT 2943
Q SS V V++ D NDN P F YR +V E++ G + ++ DAD V
Sbjct: 2581 PQ-SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHG-LVR 2638
Query: 2944 CYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD--GKFQASVTVEIFV 3001
++ GDP G F + + R++ LD E A++ L V A+D G A V I V
Sbjct: 2639 FTVSSGDPSGLFELDESSGTLRLA--HALDCETQARHQLVVQAADPAGAHFALAPVTIEV 2696
Query: 3002 LDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL--HGP---GAH 3056
DVND+ P L + V E+ PG + + A D D ++ YSL GP G
Sbjct: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
Query: 3057 EFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPS 3116
F L+ TGEL D E + F L+ A D G S +++ V ++ P F
Sbjct: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAP 2816
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPL- 3175
V + + V A D D GA+ V+YSL S+ +F I+ TTG + L
Sbjct: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSP-YFGINQTTGALYLRVDSR 2875
Query: 3176 -------------QVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208
+ R +AP EL + G P+P S TV V+V
Sbjct: 2876 APGSGTATSGGGGRTRREAPRELRLEVIARG-PLPGSRSATVPVTV 2920
Score = 770 bits (1989), Expect = 0.0
Identities = 782/2837 (27%), Positives = 1230/2837 (43%), Gaps = 222/2837 (7%)
Query: 689 LQNQESSDEEFTSLS----TYQINHYTPQFEDH---FPQS---IDVLESVPINTPLARLA 738
L ++ FT+++ T ++ DH FPQ+ + V E T
Sbjct: 107 LDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEP 166
Query: 739 ATDPDAGFNGKLVYVIADGNEEGCFDIELETGL-------LTVAAPLDYEATNFYILNVT 791
A D DAG G Y ++ F +E G L V LD E + Y+L +
Sbjct: 167 ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLE 226
Query: 792 VYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSED 851
YD G+P + + LL V + D ND+AP F Y +SE G+ + ++ DAD+
Sbjct: 227 AYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGV 286
Query: 852 NGRVRYTLLSPTEK----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
NG V Y + + FS+ TG L + LD E + L V+ARD H
Sbjct: 287 NGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARD--GGAHPELG 344
Query: 908 VTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV 963
+ + + D NDN P ++ +V E PPG ++ + SDPD G V V
Sbjct: 345 SAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVN-V 403
Query: 964 LMDGAHGTFRVDLMTGALIL---ERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV 1020
++G G F + + L R LD E R YNL + A+D G P R V + V
Sbjct: 404 SLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHV 462
Query: 1021 LDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF 1080
DVN+N P + E + G+ V+ V A+D D G +G++ Y L G F
Sbjct: 463 TDVNDNA-PAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWF 521
Query: 1081 SINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQA 1140
SI+ +G+I T A LD E L V+A D G PL+S V + + D NDN PQ +
Sbjct: 522 SIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
Query: 1141 VFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTA 1197
+ S+ E GT LQ+ A D DS G L++++ +G + F I +G + T
Sbjct: 582 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTT 641
Query: 1198 QQLDRENKDEHI-LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLS 1256
+ LDR+ VT +D G LKS V V + D NDNPP F + + + +
Sbjct: 642 RTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSP 699
Query: 1257 PVSPGPVYRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTFTAGEYNI-- 1313
P + V RL A D D+G +GR++Y I + F++D +G+++ + ++
Sbjct: 700 PGT--AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQ 757
Query: 1314 LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV 1373
L I A D G S R+ I +P + P F++ Y F+V E VG++
Sbjct: 758 LEIGAEDGGGLQAEPSARVDISIVP---GTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA 814
Query: 1374 EGRPGLF---WFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT-- 1428
PG ++SGGD F ++ +G + RPLD R L +EV GS
Sbjct: 815 HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLD-RELLGPVLELEVRAGSGVPP 873
Query: 1429 --IATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIH 1486
+V + ++ ++N + P F V +P +T PG + ++A+D D G + T
Sbjct: 874 AFAVARVRV-LLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTF- 931
Query: 1487 GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE 1546
+ G F +DP++G + + L GP+ H L + RD P + + + + V+
Sbjct: 932 -TLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPA-HELELEARDGGSPPRTSHFRLRVVVQ 989
Query: 1547 DGNLH--PPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D PRF Y +P GT++LQV+A D G + Y L + F
Sbjct: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFG 1046
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSP---QWHDLATVIIHVYPSDRSAPIFS 1661
+ G + + LD+ + L V A Q ATV + + + +P S
Sbjct: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
Query: 1662 KSEYFVEIPESIPVGSPILLVSAMS-----PSEVTYELREGNKDG-VFSMNSYSGLISTQ 1715
+ F+ + E+ P G+ + V A +TY L++ ++D F ++ +G ++T
Sbjct: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
Query: 1716 KKLDHEKISSYQL--KIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVG------QI 1767
+ LD E+ SSYQL +++ T V V ++D NDN+P FL+++ Q+
Sbjct: 1167 QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV 1226
Query: 1768 SEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE 1827
+ P +++ + A D D+ N ++Y + P + + F + P G L +
Sbjct: 1227 PDRVPPGTLVT-------TLQAKDPDEGENGTILYTLTGPGS-ELFSLHPHSGELLTAAP 1278
Query: 1828 MDYESMPSFQFCVYVHDQGSPVLFAPRPA--QVIIHV---RDVNDSPPRFSEQ------- 1875
+ P + + HDQGSP PR A Q+++ V + + PP +E+
Sbjct: 1279 LIRAERPHYVLTLSAHDQGSP----PRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVP 1334
Query: 1876 -IYEVAIVGPIHPGMELLMVRASDED--SEVNYSIKTGNADEAVT--IHPVTGSISVLNP 1930
+ V + PG L V A + + Y++ G AD T + +G + + P
Sbjct: 1335 VVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTL-VGGADPEGTFALDAASGRLYLARP 1393
Query: 1931 AFLGLS---RKLTIRASDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKENLQDR 1984
R LT+RA L+++ + QV D++ F +D A+ EN +
Sbjct: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQV-QVQDENEHAPAFARDPLALALPENPEPG 1452
Query: 1985 KALVIL---GAQGNHLNDTLSYFLLN---GTDMFHMVQSAGVLQT-RGVAFDREQQDTHE 2037
AL A G N + Y LL + G L RG+ DRE
Sbjct: 1453 AALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL--DRETTPALL 1510
Query: 2038 LAVEVRD---NRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSA 2094
L VE D N + +R A+ RV + D NDN P F P + + PG V A
Sbjct: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPEDQPPGPAALHVVA 1569
Query: 2095 TDEDLGTNGAVTYEFAEDYT-YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSL 2153
D DLG V+Y A +FR+ G +S+ +P D + ++ L V+A D G+P
Sbjct: 1570 RDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR 1629
Query: 2154 QSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE---GLRLIYNIV 2208
+ + + V+V N P FQ Y V + EN T +L +A P+ ++ Y V
Sbjct: 1630 SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV 1689
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT-ALGSFSEATVEVLVEDVND 2267
E F+ D TGVLT LD E + + TV A D + + TV V VED ND
Sbjct: 1690 SSES---FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
Query: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGS 2327
+ PTF + + EG QT + L ASD D G N + Y+I++ D S F ++ +
Sbjct: 1747 HAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILD--GDPSGAFVLDLA 1803
Query: 2328 TGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEAN 2387
+GE T++ LD E + F +++ A D G P L+ L+ V V D ND+ P F P Y
Sbjct: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVE 1863
Query: 2388 VSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD 2447
V E G L+L++QA DPD+ + Y + +G F + SSG + +
Sbjct: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA-FLLEPSSGELRTAAALDREQC 1922
Query: 2448 SSYNLRVGASDGV----FRATVPVYINTTNANKYSPEFQQHLYEAELAE-NAMVGTKVID 2502
SY V A DG TV V I + N ++P F L T +
Sbjct: 1923 PSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
Query: 2503 LLAI---DKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMA 2559
L + D+D+G +I Y + + G+I + +RV+ I
Sbjct: 1983 LATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATD 2042
Query: 2560 RDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
R A + + L E + P+F + +I+ N +P++ A A G N
Sbjct: 2043 LGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGP 2101
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE---NQTLDFFIKAQDGGPPHWNSLVP 2676
+TYS+ + K I P TG + V+ S GL+ + L ++A+ GG + L
Sbjct: 2102 ITYSILSGN-EKGTFSIQPSTGAITVR-SAEGLDFEVSPRLRLVLQAESGGAFAFTVLT- 2158
Query: 2677 VRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA----VAAQDPVIYSLVRGTTP 2732
L + + P+F P Y PE P + V+A + + YSL
Sbjct: 2159 --LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
Query: 2733 ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
G+F +DP TG I +D E ++ +MA + +V ++ + V D ND
Sbjct: 2217 R----GLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
Query: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDS 2852
NRP P++ ++E+ +G+ + QVT D D+G + Y LS S + F++
Sbjct: 2273 NRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSP---SGPQDPFSVGR 2326
Query: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR 2912
G ++ LD E C Y ++A+D +A + V + D NDNAP F+ Y+
Sbjct: 2327 YGGRVSLTGPLDFEQCDRYQLQLLAHDGPH----EGRANLTVLVEDVNDNAPAFSQSLYQ 2382
Query: 2913 GSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGIS-QVGDEWRISSRKT 2971
++E++ PG + ++ D D S N ++ ++ P F + G + I
Sbjct: 2383 VMLLEHTPPGSAILSVSATDRD-SGANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVA 2439
Query: 2972 LDREHTAKYLLRVTASD----GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
L + + + + A D G+ A TV + + D ND++P + Y V ED+ PG
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
Query: 3028 HFILKVSATDLD-TDTNAQITYS-LHGPGAHEFKLDPHTGE--------------LTTLT 3071
+L + ATD D + ++A + YS + G F+L+P E L L
Sbjct: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
Query: 3072 ALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVK 3129
LD E +NL A D G +S +T+ V DVNDN P F + V V ++T V
Sbjct: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
Query: 3130 TPVAVVFARDPDQGANAQVVYSLPD-SAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
+ V A D D G + V +++ G F +D ++G +RL L QA +L V+
Sbjct: 2619 AELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
Query: 3189 ASD-LGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP- 3246
A+D G L VT+ V + D+ P F S V E+ PPGT V L +
Sbjct: 2679 AADPAGAHF---ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
Query: 3247 ---GAEKTGYRVVSGNEQGR--FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSL 3301
G + +GR F L++ TG L D+E + + L + + + +L
Sbjct: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAA--DAGNL 2793
Query: 3302 SDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI 3361
S TV V +T +E+ P F + +V E A G + V ATDEDG + + YSL
Sbjct: 2794 SASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLA 2853
Query: 3362 GGNQLGHFTIHPKKGEL 3378
+ +F I+ G L
Sbjct: 2854 TSSP--YFGINQTTGAL 2868
Score = 725 bits (1871), Expect = 0.0
Identities = 780/2866 (27%), Positives = 1244/2866 (43%), Gaps = 263/2866 (9%)
Query: 881 LDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940
LDRE RY D + ++ + + D+ND++P L+VPE
Sbjct: 107 LDREQRDRYRFTAVTPDG--------ATVEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
Query: 941 GTVLTFLDASDPDLGPAGEVRYVLM-DGAHGTFRVDLMTGA-------LILERELDFERR 992
GT A D D G G Y L DGA TFR++ G L++ ELD E R
Sbjct: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVI 1052
+ Y L L A DGG P RR ++V +LD+N+ H P F + V E+ G+ V+
Sbjct: 219 SHYMLQLEAYDGGSP-PRRAQALLDVTLLDIND--HAPAFNQSRYHAVVSESLAPGSPVL 275
Query: 1053 VVAAQDDDSGLDGELQYFL--RAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV 1110
V A D D+G++G + Y + R G FSI+ TG++Q PLD E + L V A
Sbjct: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
Query: 1111 DRGSVPLSSVTEVYIEVTDANDNPPQMS----QAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
D G+ P V + V DANDN P M+ A P + E AP G V ++ DPD
Sbjct: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP---VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLK 1223
+ ++ G G F + V L+ A++LDRE +D + L VT D+G P L+
Sbjct: 396 GDFAHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLR 453
Query: 1224 STSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS-PGP-VYRLVASDLDEGLNGRVTY 1281
+ + V+ + DVNDN P F +L+ PE L V+ PG V R+ A D D+G NG+VTY
Sbjct: 454 AEAAFVLHVTDVNDNAPAFDRQLYR---PEPLPEVALPGSFVVRVTARDPDQGTNGQVTY 510
Query: 1282 SIED-SDEEAFSIDLVTGVVSSSSTFTAGEYNI-----LTIKATDSGQPPL--SASVRLH 1333
S+ + FSID +G+++++++ +Y + L + ATD G PPL SA+V +
Sbjct: 511 SLAPGAHTHWFSIDPTSGIITTAASL---DYELEPQPQLIVVATDGGLPPLASSATVSVA 567
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVME-TDPVNHMVGVISVE---GRPGLFWFNISGG-- 1387
++ + P F T+Y+ ++ E T P + V + + G GL +++ G
Sbjct: 568 LQDVNDNEPQ-----FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLG 622
Query: 1388 -DKDMDFDIEKTTGSIVIARPLDTRRR-SNYNLTVEVTDGSRTIATQVHIFMIANINHHR 1445
F I+ +G + R LD + S+++ TV DG + +++ N +
Sbjct: 623 SSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNP 682
Query: 1446 PQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSS 1503
PQF Y + + PG +LR++A D D+G L Y I P LF LD S
Sbjct: 683 PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSP---PLFTLDEQS 739
Query: 1504 GVLVTVGKLDLGSGPSQHTLTVMVRD----QEIPIKRNFVWVTIHVEDGNLHPPRFTQLH 1559
G+L L + S L + D Q P R V I + G PP F QL
Sbjct: 740 GLLTVAWPLARRAN-SVVQLEIGAEDGGGLQAEPSAR----VDISIVPGTPTPPIFEQLQ 794
Query: 1560 YEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
Y SVP+ +APGT + V+A + G A V SL G+ G F+++A+ G++ + LD
Sbjct: 795 YVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLD 853
Query: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
+ P G P +A V + + + ++P F E V +P + G+PI
Sbjct: 854 RELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPI 913
Query: 1680 LLVSAMSP-----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIR--- 1731
+ A+ P S VT+ L G G F+++ +G + + L +++L++
Sbjct: 914 YTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972
Query: 1732 -GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHAS 1790
GS + + VVV + AP F T+ + + ++ + A
Sbjct: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQ-------VQAQ 1025
Query: 1791 DSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL 1850
D + Y + A F ++P G L + + +D E+ + V L
Sbjct: 1026 APD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAEL 1082
Query: 1851 FAPR-PAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----Y 1905
A V + + + N+ PR SE +A+ PG + V A+D DS N Y
Sbjct: 1083 GQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTY 1142
Query: 1906 SIKTGNAD-EAVTIHPVTGSISVLNPAFLGL--SRKLTIRASDG---LYQDTALVKISLT 1959
S++ + D +A IHP TG ++ L S +L ++ DG T V +++
Sbjct: 1143 SLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202
Query: 1960 QVLDKSLQFDQDVYWAA------VKENLQDRKALVILGAQG--NHLNDTLSYFLLN-GTD 2010
+ D S F Q A V + + + L A+ N T+ Y L G++
Sbjct: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262
Query: 2011 MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI---------- 2060
+F + +G L T R ++ + L + D +P R A + V +
Sbjct: 1263 LFSLHPHSGELLTAAPLI-RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPP 1321
Query: 2061 EDVNDNPPKFKHLPYYTIIQ-DGTEPGDVLFQVSATDEDLGTNGAVTYEF---AEDYTYF 2116
D+ + P T+ +G PG +L V+A E G GA+TY A+ F
Sbjct: 1322 PDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAP-EPAGV-GALTYTLVGGADPEGTF 1379
Query: 2117 RIDPYLGDISLKKPFDYQALNKYHLKVIARDG--GTPSLQSEEEVLVTVRNKSNPLFQSP 2174
+D G + L +P D++A + + +G G + +V V N+ P F
Sbjct: 1380 ALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARD 1439
Query: 2175 YYKVRVPENITLYTPILHTQARSPEG----LRLIYNIVEEEP-LMLFTTDFKTGVLTVTG 2229
+ +PEN + +A +G + Y ++ +EP + D +TG L+
Sbjct: 1440 PLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPR 1499
Query: 2230 PLDYESKTKHVFTVRATDTALGSF----SEATVEVLVEDVNDNPPTFSQLVYTTSISEGL 2285
LD E+ + V ATD + + + V V D NDN P F+ + E
Sbjct: 1500 GLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPEDQ 1558
Query: 2286 PAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHF 2345
P + ++A D D G VSY++ G F+++ STG +S V+ LD E +
Sbjct: 1559 PPGPAALHVVARDPDLGEAARVSYRLASGGDG---HFRLHSSTGALSVVRPLDREQRAEH 1615
Query: 2346 HVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAID 2405
+ V A D G PP + ++ V+V+D+ND P F+Q +Y + E G +L ++A D
Sbjct: 1616 VLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATD 1675
Query: 2406 PDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATV 2465
PD ++ Y G F ++ +G+++ + NL V A D R +
Sbjct: 1676 PDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQD---RGSP 1729
Query: 2466 PVYINTT------NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
P + T + N ++P F E+ E T + L A D D G G + Y
Sbjct: 1730 PQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYR 1788
Query: 2520 IINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT-- 2576
I++ S F ++ +G+ T++ LDRE E +++ ARDGG T+ + +T
Sbjct: 1789 ILDGDPSGAFVLDLASGEFGTMRPLDRE--VEPAFQLRIEARDGGQPALSATLLLTVTVL 1846
Query: 2577 DENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEI 2636
D ND+ P F Y+V + +V + ++Q+ A+D D G N VTY + ++E
Sbjct: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLE- 1905
Query: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDG---GPPHWNSLVPVRLQVV----------P 2683
P +G ++ +L + + F + A DG GP V + ++ V P
Sbjct: 1906 -PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSP 1964
Query: 2684 KKVSLPK----FSEPLYTFSA--PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKD 2737
++ LP+ FS P + ED G+ I+ +A P GTT
Sbjct: 1965 LRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP------GTT------ 2012
Query: 2738 GVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT--DVVSLVSVNIQVGDVNDNRP 2795
+D TG I+V + + + ++A L ++ V +Q G+ + P
Sbjct: 2013 ----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQ-GEA-ERGP 2066
Query: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
F +A + EN P GT ++ A+ G +G ++Y + + N F+I +G
Sbjct: 2067 RFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILS---GNEKGTFSIQPSTG 2122
Query: 2856 WIT--TLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
IT + + LD E + A G + ++ +++ D NDNAPRF Y
Sbjct: 2123 AITVRSAEGLDFEVSPRLRLVLQAESGGAF----AFTVLTLTLQDANDNAPRFLRPHYVA 2178
Query: 2914 SVVENSEPGELVATLKTLDADISEQNR--QVTCYITEGDPL-GQFGISQVGDEWRISSRK 2970
+ E S P L L ++AD +Q Q++ + P G F + I++
Sbjct: 2179 FLPE-SRP--LEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGT--ITTTA 2233
Query: 2971 TLDREHTAKYLLRVTASDGKFQA---SVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
LDRE A+ L + A+D A S T+ + V+D NDN P Q + +V ED G
Sbjct: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLG 2292
Query: 3028 HFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKA 3087
I +V+ D+D+ S GP F + + G ++ LD E+ D + L A
Sbjct: 2293 SEIAQVTGNDVDSGPVLWYVLSPSGP-QDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLA 2351
Query: 3088 TDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQ 3147
DG +A++T+ VEDVNDNAP F S V + ++T + + V A D D GAN
Sbjct: 2352 HDGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
Query: 3148 VVYSLPDSAEGHFSIDATTGVIRL---EKPLQVRPQAPLELTVRASDLGTPIPLSTLGTV 3204
+ Y L A+G FS+D G + L +++ + A D G P + TV
Sbjct: 2411 ISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP-GRAARATV 2468
Query: 3205 TVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEK---TGYRVVSGNEQ 3261
V + D+ P F + + V V ED PPG+ +L L G+ Y ++SGN
Sbjct: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG 2528
Query: 3262 GRFRLDART--------------GILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTV 3307
F+L+ R G L + LDFE+ +Y L++ + + S V V
Sbjct: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV 2588
Query: 3308 MVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLG 3367
V + DVN++ P F + Y V E+ VG +L V A+D D + + +++ G+ G
Sbjct: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSG 2648
Query: 3368 HFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFF 3427
F + G L++A ALD E + + L ++A D + I+V DVND+ P F
Sbjct: 2649 LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFAL-APVTIEVQDVNDHGPAFP 2707
Query: 3428 QLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKG---NNGSAFRVTPD-GWL 3483
ST+V EN P G+ V L D D+ G + G AF + G L
Sbjct: 2708 LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGEL 2767
Query: 3484 VTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGED 3543
E ++L + A+D+G LS+ +V V VT + Y P L V E
Sbjct: 2768 RARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEG 2825
Query: 3544 EFQGGMVGKIHATDRD--PQDTLTYSLAEEETLGRHFSVGAPDGKI 3587
+G +G + ATD D + YSLA T +F + G +
Sbjct: 2826 ARRGHSLGHVQATDEDGGADGLVLYSLA---TSSPYFGINQTTGAL 2868
Score = 724 bits (1869), Expect = 0.0
Identities = 771/2866 (26%), Positives = 1219/2866 (42%), Gaps = 280/2866 (9%)
Query: 395 YVLKPSSENVGFKLNARTG--------LITTTKLMDFHDRAHYQLHIR-----TSPGQAS 441
Y L F+L R G L+ T +L D +R+HY L + + P +A
Sbjct: 180 YALSGDGAGETFRLETRPGPDGTPVPELVVTGEL-DRENRSHYMLQLEAYDGGSPPRRAQ 238
Query: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
++ + ++D N+HAP FN+S Y + E++ PG+ VL V A+D D G NG VTY I +
Sbjct: 239 ALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQ 298
Query: 502 AL---PFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
+ PFSID + G++ +P+D+E +R++ V+A D G+ + + +R+ N
Sbjct: 299 SEGDGPFSIDAHTGLLQLERPLDFE-QRRVHELVVQARDGGA-HPELGSAFVTVHVRDAN 356
Query: 559 DNQP----MFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNH 614
DNQP +F + + + + P G+ + +S D D+ + +F L+
Sbjct: 357 DNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALST 416
Query: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTG 674
VI L L + +Y+L++TA+D SP P+ +
Sbjct: 417 QDSVIYLVCVARRLDREERDAYNLRVTATDS---GSP---------------PLRAEAAF 458
Query: 675 VLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPL 734
VL +N P F+ + + E + +
Sbjct: 459 VL--------------------------HVTDVNDNAPAFDRQLYRPEPLPEVALPGSFV 492
Query: 735 ARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
R+ A DPD G NG++ Y +A G F I+ +G++T AA LDYE L V D
Sbjct: 493 VRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATD 552
Query: 795 LGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGR 854
G P +S ++V ++D NDN P+F Y ++ E T+ GT ++T DADS G
Sbjct: 553 GGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGL 612
Query: 855 VRYTL-----LSPTEKFSLHPLTGELVVTGHLDRESEP-RYILKVEARDQPSKGHQLFSV 908
+ Y+L S + F + +G++ T LDR+ P + V A D G L S+
Sbjct: 613 LSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD----GGGLKSM 668
Query: 909 TDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY-VLMDG 967
+ + L D NDN PQ + PPGT + L A DPD G G + Y +L
Sbjct: 669 VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGN 728
Query: 968 AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
+ F +D +G L + L + L + A DGG L V++ ++
Sbjct: 729 SPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG-GLQAEPSARVDISIVPGTPT- 786
Query: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG 1087
PP F + V E+ GT V +V A + L + L G FS++ +G
Sbjct: 787 -PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGGDPRGLFSLDAVSG 844
Query: 1088 MIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQ 1147
++QTL PLDRE + G P +V V + + D NDN P +
Sbjct: 845 LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDE 1207
+ GT + L A DPDS ++TF + +G G F + P TG + + L
Sbjct: 905 PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963
Query: 1208 HILEVTVLDNGEPSLKSTSRVVVGILDVNDN--PPIFSHKLFNVRLPERLSPVSPGPVYR 1265
H LE+ D G P S R+ V + DV P F+ + V LP S + G
Sbjct: 964 HELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLP---SGTTAGTQVL 1020
Query: 1266 LVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTG--VVSSSSTFTAGEYNILTIKA---- 1318
V + +G G +TY + + F ++ +G V ++ A E IL + A
Sbjct: 1021 QVQAQAPDG--GPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGS 1078
Query: 1319 -TDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
+ GQ +A+VR+ I S L+ D T+ V E P VG +
Sbjct: 1079 KAELGQQTGTATVRVS---ILNQNEHSPRLSEDPTF--LAVAENQPPGTSVGRVFATDRD 1133
Query: 1374 EGRPGLFWFNISGGDKDMD-FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---RTI 1429
G G +++ +D F I TG + + LD ++S+Y L V+V DG R+
Sbjct: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
Query: 1430 ATQVHIFMIANINHHRPQFLETR------YEVRVPQDTVPGVELLRVQAIDQDKGK--SL 1481
VH+ + ++N + P FL+ ++VP PG + +QA D D+G+ ++
Sbjct: 1194 TGTVHV-AVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI 1252
Query: 1482 IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWV 1541
+YT+ G PGS LF L P SG L+T L P + LT+ DQ P + + +
Sbjct: 1253 LYTLTG---PGS-ELFSLHPHSGELLTAAPLIRAERP-HYVLTLSAHDQGSPPRSASLQL 1307
Query: 1542 TIHVEDGNL---HPPRFTQLHYEASVP--------DTIAPGTELLQVRAMDADRGVNAEV 1590
+ V PP + A VP + + PG+ L V A + GV A +
Sbjct: 1308 LVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-PAGVGA-L 1365
Query: 1591 HYSLLKG-NSEGFFNINALLGIITLAQKLD-QANHAPHTLTVKAEDQGSPQWHDLATVII 1648
Y+L+ G + EG F ++A G + LA+ LD +A LTV+AE G L V +
Sbjct: 1366 TYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGAR-LLRVQV 1424
Query: 1649 HVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP------SEVTYE-LREGNKDG 1701
V + AP F++ + +PE+ G+ + A S+V Y LR+
Sbjct: 1425 QVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP 1484
Query: 1702 VFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG-----AFTDVMVVVDIIDENDNAP 1756
+++ +G +S + LD E + L + ++ V V + DENDNAP
Sbjct: 1485 ALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP 1544
Query: 1757 MFLKSTFVGQISEAAPLYSMIMDKNNNPFVIH--ASDSDKEANSLLVYKILEPEALKFFK 1814
+F + V + P P +H A D D + + Y+ L F+
Sbjct: 1545 VFASPSRVRLPEDQPP----------GPAALHVVARDPDLGEAARVSYR-LASGGDGHFR 1593
Query: 1815 IDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVI--IHVRDVNDSPPRF 1872
+ S G L++V +D E V D GSP PR A + + V DVND P F
Sbjct: 1594 LHSSTGALSVVRPLDREQRAEHVLTVVASDHGSP----PRSATQVLTVSVADVNDEAPTF 1649
Query: 1873 SEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGN-ADEAVTIHPVTGSISVLNPA 1931
+Q Y V + PG LL +RA+D D N + G + E+ ++ P TG ++ L
Sbjct: 1650 QQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLR-- 1707
Query: 1932 FLGLSRK------LTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQ 1982
L R+ LT+ A D V++++ D + F V E Q
Sbjct: 1708 --ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEG-Q 1764
Query: 1983 DRKALVILGAQGNHL--NDTLSYFLLNG--TDMFHMVQSAGVLQTRGVAFDREQQDTHEL 2038
D + L +L A + N L Y +L+G + F + ++G T DRE + +L
Sbjct: 1765 DPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR-PLDREVEPAFQL 1823
Query: 2039 AVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDED 2098
+E RD P A L+ V++ D ND+ P F Y + + G +L Q+ A D D
Sbjct: 1824 RIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPD 1883
Query: 2099 LGTNGAVTYEF-AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS-LQSE 2156
G NG VTY A F ++P G++ D + Y V A DG L +
Sbjct: 1884 AGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT 1943
Query: 2157 EEVLVTVR--NKSNPLFQSPYYKVRVP------ENITLYTPILHTQARSPEGLRLIYNIV 2208
V +TVR N P F + ++R+P TL L + R I +
Sbjct: 1944 VSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003
Query: 2209 EEEPLMLFTTDFKTGVLTVT-GPLDYESKTKHVFTVRATDTALGSFSEATVEVL-VEDVN 2266
P T D TG + V P+ + + +F V ATD + S V ++ ++
Sbjct: 2004 AGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIV-ATDLGRPARSATGVIIVGLQGEA 2062
Query: 2267 DNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQING 2326
+ P F + +I E P TP++ A G N ++Y I+ + F I
Sbjct: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGT--FSIQP 2119
Query: 2327 STGEMS--TVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384
STG ++ + + LD+E + ++A G T++ + + D NDN P F +P Y
Sbjct: 2120 STGAITVRSAEGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY 2176
Query: 2385 EANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFF-INSSSGIISMFNLCK 2443
A + E +L+V+A D D ++ Y + + R F ++ ++G I+ +
Sbjct: 2177 VAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILD 2236
Query: 2444 KHLDSSYNLRVGASDG-----VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGT 2498
+ + + L + A+D V AT+ V + TN N+ P Q +E ++E+A++G+
Sbjct: 2237 REIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNR--PTIPQP-WELRVSEDALLGS 2293
Query: 2499 KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKV 2557
++ + D DSGP + Y + + FS+ G+++ LD E +++
Sbjct: 2294 EIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDR--YQLQL 2349
Query: 2558 MARDG--GGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEG 2615
+A DG GR + +++ D NDN P F S Y V + + S ++ V A D D G
Sbjct: 2350 LAHDGPHEGR---ANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
Query: 2616 QNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ---TLDFFIKAQDGGPPHWN 2672
N ++Y + D ++P G + V L + +D ++A+D G P
Sbjct: 2407 ANGHISYHLASP---ADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRA 2463
Query: 2673 SLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTP 2732
+ V +Q+ + P F+ Y + EDLP GS + ++A A ++ V +
Sbjct: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
Query: 2733 ESNKDGVFSLDP--------------DTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVV 2778
N VF L+P G + + +P+D ES Y + V A
Sbjct: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS 2583
Query: 2779 SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSA 2838
S+V V + V DVNDN PVF Y+ + E+ PVG ++ V A D D G G V + +S+
Sbjct: 2584 SVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS 2643
Query: 2839 -DPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYD-HGQTIQLSSQALVQVSI 2896
DP LF +D SG + LDCET + V A D G L A V + +
Sbjct: 2644 GDPSG----LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFAL---APVTIEV 2696
Query: 2897 TDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEG-DPLGQF 2955
D ND+ P F SV EN PG LV TL +D D R + G P G+
Sbjct: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
Query: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVTVEIFVLDVNDNSPQCSQL 3014
+ + +R D EHT + L V A+D G ASVTV + V ++ P
Sbjct: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAP 2816
Query: 3015 LYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL----------HGPGAHEFKLD--- 3061
+ +V E GH + V ATD D + + YSL GA ++D
Sbjct: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRA 2876
Query: 3062 PHTGELTT----LTALDRERKDVFNLVAKATDGGGRSCQADITLHV 3103
P +G T+ T + R+ ++A+ G RS +T+ +
Sbjct: 2877 PGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDI 2922
Score = 710 bits (1833), Expect = 0.0
Identities = 744/2782 (26%), Positives = 1172/2782 (42%), Gaps = 253/2782 (9%)
Query: 104 TALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMP 162
T L+RE R Y L ++A + + A + V +LD ND P F+ Y +SE +
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 163 LKSPICKVTATDADLGQNAEFYYAFNTRSEM----FAIHPTSGVVTVAGKLNVTWRGKHE 218
SP+ +V A+DAD G N Y N R F+I +G++ + L+ R HE
Sbjct: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
Query: 219 LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278
L V A D G+ F + VHV A P++ + + S DG+ + +
Sbjct: 330 LVVQARDGGAHPELGSAF-----VTVHVRDANDNQPSMTVIFL----SADGSPQVS---E 377
Query: 279 ANSSGAEVESVEVVGGDPGKHFKAIKS-------YARSNEFS---LVSVKDINWMEYLHG 328
A G V + V D G S +A S + S LV V E
Sbjct: 378 AAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDA 437
Query: 329 FNLSLQAR-SGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQ-LSEFSPPGSRVVMVRV 386
+NL + A SGS P H+ ++ F++ +YR + L E + PGS VV RV
Sbjct: 438 YNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVV--RV 495
Query: 387 TPAFPN------LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPG-- 438
T P+ + Y L P + F ++ +G+ITT +D+ QL + + G
Sbjct: 496 TARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGL 555
Query: 439 ---QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTY 495
+S V + + D N++ P F R+ Y+ +L E PGT L VTATD D G G ++Y
Sbjct: 556 PPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSY 615
Query: 496 S----IAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIF 551
S + + PF ID + G + T++ +D + + F V A D G + V +F
Sbjct: 616 SLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD-GGGLKSMVYVKVF 674
Query: 552 LQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEY 609
L + NDN P F SI P G +++ + A D D+ + L Y I++GN
Sbjct: 675 LS--DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPL 732
Query: 610 FDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVT 669
F L+ SG++++ P L + L+I A DG
Sbjct: 733 FTLDEQSGLLTVAWP---LARRANSVVQLEIGAEDGG----------------------- 766
Query: 670 CDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVP 729
GLQ + S+ + + + TP + V E V
Sbjct: 767 ------------------GLQAEPSARVDISIVP----GTPTPPIFEQLQYVFSVPEDVA 804
Query: 730 INTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILN 789
T + + A +P G + ++ G+ G F ++ +GLL PLD E +
Sbjct: 805 PGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLEL 863
Query: 790 VTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADS 849
G P + + V + D NDN+P FP + + +T GT I L D DS
Sbjct: 864 EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDS 923
Query: 850 EDNGRVRYTLLS-PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSV 908
N RV +TLL+ F++ P TG + + L P + L++EARD S S
Sbjct: 924 GVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRT--SH 981
Query: 909 TDLIITLEDVNDN--SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD 966
L + ++DV +P+ + R+ +P GT + + A PD GP ++ +
Sbjct: 982 FRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPI--TYHLAAE 1039
Query: 967 GAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNEN 1026
GA F ++ +G L + LD E + Y L + A G + + V V +N+N
Sbjct: 1040 GASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQN 1099
Query: 1027 LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFL-RAGTGLAAFSINQD 1085
H P + V EN P GT V V A D DSG +G L Y L + AF I+
Sbjct: 1100 EHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQ 1159
Query: 1086 TGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV---- 1141
TG + TL LDRE S Y L V D GS P S+ V++ V D NDN P QA
Sbjct: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1219
Query: 1142 --FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ 1199
+ + P GT V L A DPD G + + +T G F +HP +G L TA
Sbjct: 1220 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAP 1278
Query: 1200 LDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILD---VNDNPPIFSHKLFNVRLPERLS 1256
L R + ++L ++ D G P ++ +++V +L + + PP + + +P L+
Sbjct: 1279 LIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLT 1338
Query: 1257 PVS-----PGPVYRLVASDLDEGLNGRVTYSIED--SDEEAFSIDLVTG--VVSSSSTFT 1307
+ PG + VA+ G+ G +TY++ E F++D +G ++ F
Sbjct: 1339 VTAAEGLRPGSLLGSVAAPEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
Query: 1308 AG-EYNILTIKAT---DSGQPPLSASVRLHIEWIPWPRPSSIPLAF--------DETYYS 1355
AG + LT++A +G L V++ E P + PLA Y+
Sbjct: 1398 AGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT 1457
Query: 1356 FTVMETD--PVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRR 1413
F + D N V + P + ++ TG++ R LD
Sbjct: 1458 FRASDADGPGPNSDVRYRLLRQEPPV-----------PALRLDARTGALSAPRGLDRETT 1506
Query: 1414 SNYNLTVEVTD----GSRTIATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELL 1468
L VE TD SR A +V + + N + P F VR+P+D PG L
Sbjct: 1507 PALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAAL 1565
Query: 1469 RVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVR 1528
V A D D G++ + + G F+L S+G L V LD ++H LTV+
Sbjct: 1566 HVVARDPDLGEAARVSYRLAS--GGDGHFRLHSSTGALSVVRPLD-REQRAEHVLTVVAS 1622
Query: 1529 DQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNA 1588
D P + +T+ V D N P F Q Y + + PGT LL +RA D D G N
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
Query: 1589 EVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVII 1648
+V Y G S F+++ G++T + LD+ LTV A+D+GSP TV +
Sbjct: 1683 QVTYG---GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV 1739
Query: 1649 HVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVF 1703
V + AP F + +E+PE + ++ A P ++ Y + +G+ G F
Sbjct: 1740 AVEDENDHAPTFGSAHLSLEVPEG-QDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAF 1798
Query: 1704 SMNSYSGLISTQKKLDHEKISSYQLKI--RGSNMAGAFTDVMVVVDIIDENDNAPMFLKS 1761
++ SG T + LD E ++QL+I R +++ V ++D ND+AP F
Sbjct: 1799 VLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVP 1858
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGT 1821
+ ++ E P ++++ + A D D AN + Y L F ++PS G
Sbjct: 1859 AYSVEVPEDVPAGTLLLQ-------LQAHDPDAGANGHVTY-YLGAGTAGAFLLEPSSGE 1910
Query: 1822 LTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
L + +D E PS+ F V D G+ V I VRDVND P F + +
Sbjct: 1911 LRTAAALDREQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
Query: 1882 VGP----IHPGMELLMVRASDEDSEVNYSI---KTGNADEAVTIHPVTGSISVL-NPAFL 1933
P P + L +RA D D+ N SI G T+ TG I V +P L
Sbjct: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVAL 2029
Query: 1934 G-LSRKLTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVI 1989
G R L I A+D T ++ + L ++ +F + A ++EN +V
Sbjct: 2030 GPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVS 2089
Query: 1990 LGA-QGNHLNDTLSYFLLNGTD--MFHMVQSAGVLQTRGV-AFDREQQDTHELAVEVRDN 2045
A N ++Y +L+G + F + S G + R D E L ++
Sbjct: 2090 PRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG 2149
Query: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105
A ++ ++++D NDN P+F Y + + L QV A D D G+ G +
Sbjct: 2150 GA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQI 2206
Query: 2106 TYEFAEDYT---YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVT 2162
+Y A F +DP G I+ D + + L ++A D G+P+L + V
Sbjct: 2207 SYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVM 2266
Query: 2163 V--RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GLRLIYNIVEEEPLMLFTTD 2219
V N + P P +++RV E+ L + I + G L Y + P F+
Sbjct: 2267 VIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVG 2325
Query: 2220 FKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTT 2279
G +++TGPLD+E ++ + A D A + VLVEDVNDN P FSQ +Y
Sbjct: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLAHDGP--HEGRANLTVLVEDVNDNAPAFSQSLYQV 2383
Query: 2280 SISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTV---QE 2336
+ E P + ++ + A+D+DSG N +SY + F ++ + G + T+
Sbjct: 2384 MLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG----FSVDPNNGTLFTIVGTVA 2439
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L ++ V + A D G P V V + D ND+ P F Y V+E G
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
Query: 2397 LVLKVQAIDPD-SRDTSRLEYLILSGNQDRHFFIN--------------SSSGIISMFNL 2441
+L ++A D D SR + ++Y I+SGN R F + + G + +
Sbjct: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559
Query: 2442 CKKHLDSSYNLRVGASD---GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGT 2498
+ YNL V A+D + VPV + + N P F + Y + E+ VG
Sbjct: 2560 LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGA 2619
Query: 2499 KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKV 2557
+++ + A D D GP+G + +T+ + S F ++ +G + LD E + ++
Sbjct: 2620 ELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQA 2679
Query: 2558 MARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQN 2617
A G A V I + D ND+ P F + + S+ N + V + A D D G
Sbjct: 2680 -ADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF 2738
Query: 2618 ADVTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSL 2674
+ YS+ P ++ +N TG ++ + ++ + A D G + ++
Sbjct: 2739 GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSAS 2796
Query: 2675 VPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AAQDPVIYSLVRGT 2730
V V + V + P F P + F PE G +G V+A A V+YSL
Sbjct: 2797 VTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL---- 2852
Query: 2731 TPESNKDGVFSLDPDTGVIKVR 2752
+ F ++ TG + +R
Sbjct: 2853 ---ATSSPYFGINQTTGALYLR 2871
Score = 649 bits (1675), Expect = 0.0
Identities = 647/2266 (28%), Positives = 992/2266 (43%), Gaps = 227/2266 (10%)
Query: 1481 LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVW 1540
L+Y I + G + +D SGV+ T LD ++ T + D V
Sbjct: 76 LMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR-DRYRFTAVTPDGAT------VE 128
Query: 1541 VTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSE 1600
VT+ V D N H P F Q VP+ A GT A DAD G Y+L +
Sbjct: 129 VTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAG 188
Query: 1601 GFFNINALLGI-------ITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPS 1653
F + G + + +LD+ N + + L ++A D GSP A + + +
Sbjct: 189 ETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDI 248
Query: 1654 DRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL--REGNKDGVFSMN 1706
+ AP F++S Y + ES+ GSP+L V A VTYE+ R+ DG FS++
Sbjct: 249 NDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSID 308
Query: 1707 SYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---MVVVDIIDENDNAP----MFL 1759
+++GL+ ++ LD E+ ++L ++ + GA ++ V V + D NDN P +FL
Sbjct: 309 AHTGLLQLERPLDFEQRRVHELVVQARD-GGAHPELGSAFVTVHVRDANDNQPSMTVIFL 367
Query: 1760 KSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSM 1819
+ Q+SEAAP ++ I SD D + + + E S+
Sbjct: 368 SADGSPQVSEAAPPGQLVAR-------ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV 420
Query: 1820 GTLTIVSE-MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY- 1877
L V+ +D E ++ V D GSP L A A ++HV DVND+ P F Q+Y
Sbjct: 421 IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE--AAFVLHVTDVNDNAPAFDRQLYR 478
Query: 1878 -----EVAIVGPIHPGMELLMVRASDEDS----EVNYSIKTGNADEAVTIHPVTGSISVL 1928
EVA+ PG ++ V A D D +V YS+ G +I P +G I+
Sbjct: 479 PEPLPEVAL-----PGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTA 533
Query: 1929 NPAFLGLSRK--LTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQD 1983
L + L + A+DG +A V ++L V D QF + Y A++ E Q
Sbjct: 534 ASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQP 593
Query: 1984 RKALVILGAQGNHLND--TLSYFL-----LNGTDMFHM-VQSAGVLQTRGVAFDREQ-QD 2034
+ + A LSY L +G+ F + S V TR DR+Q
Sbjct: 594 GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTR--TLDRDQGPS 651
Query: 2035 THELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSA 2094
+ + V D + + V+V + D NDNPP+F Y I + PG + ++ A
Sbjct: 652 SFDFTVTAVDGGGLKSMVY--VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRA 709
Query: 2095 TDEDLGTNGAVTYEFAEDYT--YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D D G++G ++Y + F +D G +++ P +A + L++ A DGG
Sbjct: 710 HDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG--G 767
Query: 2153 LQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEG--LRLIYN 2206
LQ+E V + + P+F+ Y VPE++ T + QA +P G + +
Sbjct: 768 LQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLS 827
Query: 2207 IVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHV-FTVRATDTALGSFSEATVEVLVEDV 2265
+ +P LF+ D +G+L PLD E + VRA +F+ A V VL++DV
Sbjct: 828 LSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDV 887
Query: 2266 NDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
NDN P F T + TP+ L A D DSG N V++ ++ G F ++
Sbjct: 888 NDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVD 944
Query: 2326 GSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDN--PPEFRQPQ 2383
+TG + ++ L +++ A D G PP T + V V D+ P F P
Sbjct: 945 PTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPT 1004
Query: 2384 YEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK 2443
Y ++ T G VL+VQA PD + Y + + F + SG + +
Sbjct: 1005 YRVDLPSGTTAGTQVLQVQAQAPDG---GPITYHLAAEGASSPFGLEPQSGWLWVRAALD 1061
Query: 2444 KHLDSSYNLRVGASDGVFR------ATVPVYINTTNANKYSPEFQQHLYEAELAENAMVG 2497
+ Y L+V A G T V ++ N N++SP + +AEN G
Sbjct: 1062 REAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPG 1121
Query: 2498 TKVIDLLAIDKDSGPYGTIDYTIINKLASEK-FSINPN-GQIATLQKLDRENSTERVIAI 2555
T V + A D+DSGP G + Y++ K F I+P G++ TLQ LDRE + + +
Sbjct: 1122 TSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLV 1181
Query: 2556 KVMARDGGG--RVAFCTVKIILTDENDNPPQFKASE------YTVSIQSNVSKDSPVIQV 2607
+V +DGG R TV + + D NDN P F + + + V + V +
Sbjct: 1182 QV--QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
Query: 2608 LAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG 2667
A D DEG+N + Y++ ++ ++P +G + L+ E + A D G
Sbjct: 1240 QAKDPDEGENGTILYTLTGPG--SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQG 1297
Query: 2668 PPHWNSLVPVRLQVVPKKVSLPKFSEP---------------LYTFSAPEDLPEGSEIGI 2712
P ++ + + +QV+P + +EP + T +A E L GS +G
Sbjct: 1298 SPPRSASLQLLVQVLPSA----RLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG- 1352
Query: 2713 VKAVAAQDP-----VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDV 2767
+VAA +P + Y+LV G PE G F+LD +G + + +P+D E+ ++
Sbjct: 1353 --SVAAPEPAGVGALTYTLVGGADPE----GTFALDAASGRLYLARPLDFEAGPPWRALT 1406
Query: 2768 MAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKD-T 2826
+ L+ V +QV D N++ P F DP L EN G ++ A D D
Sbjct: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP 1466
Query: 2827 GRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL 2886
G + V YRL +D+ +G ++ + LD ET V A D
Sbjct: 1467 GPNSDVRYRLLRQEPPV--PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASR 1524
Query: 2887 SSQALV--QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTC 2944
A V +V +TDENDNAP FAS R + E+ PG + D D+ E R
Sbjct: 1525 RRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR 1583
Query: 2945 YITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVT--VEIF 3000
+ GD G F + S G +S + LDRE A+++L V ASD G S T + +
Sbjct: 1584 LASGGD--GHFRLHSSTG---ALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
Query: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
V DVND +P Q Y+ + E+ PG +L + ATD D N Q+TY G + F L
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG--GVSSESFSL 1696
Query: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHV--EDVNDNAPRFFPSHC 3118
DP TG LTTL ALDRE ++ NL A D G +T+ V ED ND+AP F +H
Sbjct: 1697 DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL 1756
Query: 3119 AVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDS-AEGHFSIDATTGVIRLEKPLQV 3177
++ V + +T + ++ A DPD GAN Q+ Y + D G F +D +G +PL
Sbjct: 1757 SLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
Query: 3178 RPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
+ +L + A D G P +TL +TV+V+ D+ P F +SV+VPED P GT +
Sbjct: 1816 EVEPAFQLRIEARDGGQPALSATL-LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLL 1874
Query: 3238 LQLATLTRPGAEKTGYRV--VSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-S 3294
LQL P A G+ + G F L+ +G L A+LD E P Y S+
Sbjct: 1875 LQLQAHD-PDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVD 1933
Query: 3295 RKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDV----ILTVSATDEDG 3350
++ LS +V + + DVN+H P FP P R+ + T+ A D D
Sbjct: 1934 GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDA 1993
Query: 3351 PLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDT 3410
N+ I Y L G G T+ GE++VA++ L + ATD G+P
Sbjct: 1994 GANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG 2052
Query: 3411 DIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGP---PYSFRIT 3467
I + + + PRF + + T++EN+P G+ ++ P + G P ++ I
Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVS-----PRAVHAGGTNGPITYSIL 2107
Query: 3468 KGNNGSAFRVTPDGWLVT---AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQ 3524
GN F + P +T AEGL +L +QA G + LT +
Sbjct: 2108 SGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDN 2167
Query: 3525 S------HYA---PSALPLE-IFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETL 3574
+ HY P + PLE + V D+ G G+I +YSLA +
Sbjct: 2168 APRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQI-----------SYSLAASQP- 2215
Query: 3575 GRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTTAGVHVYVW 3620
A+GL F+V + GT TTTA + +W
Sbjct: 2216 ---------------ARGL------FHVDPTTGTITTTAILDREIW 2240
Score = 565 bits (1455), Expect = e-160
Identities = 686/2589 (26%), Positives = 1097/2589 (42%), Gaps = 254/2589 (9%)
Query: 76 GDVANVFKTEEYVVGNFCFLRIRTKSSNTAL------LNREVRDSYTLIIQATEK-TLEL 128
GD A+V + E G+F + T+ S L L+RE RD+Y L + AT+ + L
Sbjct: 396 GDFAHVNVSLEGGEGHFA---LSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452
Query: 129 EALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLK-SPICKVTATDADLGQNAEFYYAF 187
A V+H+ D ND P F YR ++ L S + +VTA D D G N + Y+
Sbjct: 453 RAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSL 512
Query: 188 --NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVH 245
+ F+I PTSG++T A L+ + +L V+A D + S+A V+
Sbjct: 513 APGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVN 572
Query: 246 V-EPALRKPPAIASVVVTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAI 303
EP ++ AS+ P + GT + V DA+S + S + G
Sbjct: 573 DNEPQFQRTFYNASL---PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPF 629
Query: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFE 363
+ A S + + + + ++ + F+ ++ A G G ++ F L + +F
Sbjct: 630 RIDAHSGD--VCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVF-LSDENDNPPQFY 686
Query: 364 KAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLNARTGLITTTK 419
Y +S SPPG+ V+ +R + L Y + + F L+ ++GL+T
Sbjct: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAW 746
Query: 420 LMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPG 474
+ + QL I G + S V I IV P+F + Y ++ E++ PG
Sbjct: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
Query: 475 TSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDYELMKRIYTFR 532
TSV V A + G VT S++G P+ L FS+D G++ T +P+D EL+ +
Sbjct: 807 TSVGIVQAHNPP-GRLAPVTLSLSGGDPRGL-FSLDAVSGLLQTLRPLDRELLGPVLELE 864
Query: 533 VRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD 592
VRA P V + L ++NDN P F T + + G I T+ A+D D
Sbjct: 865 VRAGSGVPPAFAVARVRVLLD--DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD 922
Query: 593 ELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYAS 650
N + + +++G F ++ +G + L RP L ++ L++ A DG S
Sbjct: 923 SGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRP---LGPSGGPAHELELEARDG---GS 975
Query: 651 PTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHY 710
P + HF + V G GL + +S TY+
Sbjct: 976 PP-------RTSHFRLRVVVQDVGTR-----------GLAPRFNS-------PTYR---- 1006
Query: 711 TPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETG 770
+D+ T + ++ A PD G + Y +A F +E ++G
Sbjct: 1007 -----------VDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSG 1052
Query: 771 LLTVAAPLDYEATNFYILNVTVY-----DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825
L V A LD EA YIL V +LG Q++ + V++ + N+++PR
Sbjct: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELG--QQTGTATVRVSILNQNEHSPRLSEDPT 1110
Query: 826 QLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLD 882
L ++E+ GT++ + D DS NGR+ Y+L +E F +HP TGE+ LD
Sbjct: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170
Query: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLI-ITLEDVNDNSPQCITEHNR------LKVP 935
RE + Y L V+ +D S S T + + + D+NDNSP + ++VP
Sbjct: 1171 REQQSSYQLLVQVQDGGSPPR---STTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVP 1227
Query: 936 EDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGY 995
+ +PPGT++T L A DPD G G + Y L F + +G L+ L R Y
Sbjct: 1228 DRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHY 1287
Query: 996 NLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS--------FVHQGQVQENSPS 1047
L+L A D G P +L + ++ PP A V E
Sbjct: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
Query: 1048 GTQVIVVAAQDDDSGLDGELQYFLRAGTG-LAAFSINQDTGMIQTLAPLDREFASYYW-- 1104
G+ + VAA + +G+ G L Y L G F+++ +G + PLD E A W
Sbjct: 1348 GSLLGSVAA-PEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARPLDFE-AGPPWRA 1404
Query: 1105 LTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWD- 1163
LTV A G + + V ++V D N++ P ++ ++ E+ G ++ A D
Sbjct: 1405 LTVRAEGPGGAG-ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDA 1463
Query: 1164 ----PDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDN-G 1218
P+S + +L + + + TG LS + LDRE +L V D
Sbjct: 1464 DGPGPNSDVRYRL---LRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPA 1520
Query: 1219 EPSLKSTSRVV--VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGL 1275
S + +RV V + D NDN P+F+ VRLPE PGP +VA D D G
Sbjct: 1521 NASRRRAARVSARVFVTDENDNAPVFASP-SRVRLPE---DQPPGPAALHVVARDPDLGE 1576
Query: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGE--YNILTIKATDSGQPPLSASVRLH 1333
RV+Y + + F + TG +S + ++LT+ A+D G PP SA+ L
Sbjct: 1577 AARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLT 1636
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGLFWFNISGGDKDMD 1392
+ + F + YS + E +P ++ + + + G GG
Sbjct: 1637 VSVAD---VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES 1693
Query: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHI-FMIANINHHRPQFLE 1450
F ++ TG + R LD + NLTV D GS T V + + + N H P F
Sbjct: 1694 FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1753
Query: 1451 TRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVT 1508
+ VP+ P L ++A D D G + L Y I DP A F LD +SG T
Sbjct: 1754 AHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDG-DPSGA--FVLDLASGEFGT 1809
Query: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
+ LD P+ L + RD P + +T+ V D N H P F Y VP+ +
Sbjct: 1810 MRPLDREVEPA-FQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDV 1868
Query: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTL 1628
GT LLQ++A D D G N V Y L G + G F + G + A LD+ +T
Sbjct: 1869 PAGTLLLQLQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELRTAAALDREQCPSYTF 1927
Query: 1629 TVKAED-QGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIP-VGSPILLVSAM- 1685
+V A D + +V I V + AP F S + +P P +P L ++ +
Sbjct: 1928 SVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR 1987
Query: 1686 -------SPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGA 1738
+ + + Y L G +++SY+G I + S L R +
Sbjct: 1988 AEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVAR-------SPVALGPRDRVLFIV 2039
Query: 1739 FTDV---------MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHA 1789
TD+ +++V + E + P F +++ I E AP + I+ +P +HA
Sbjct: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV----SPRAVHA 2095
Query: 1790 SDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE--MDYESMPSFQFCVYVHDQGS 1847
+ N + Y IL F I PS G +T+ S +D+E P + + G+
Sbjct: 2096 GGT----NGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA 2151
Query: 1848 PVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHP-GMELLMVRASDED----SE 1902
+ + ++D ND+ PRF Y VA + P LL V A D D +
Sbjct: 2152 FAF-----TVLTLTLQDANDNAPRFLRPHY-VAFLPESRPLEGPLLQVEADDLDQGSGGQ 2205
Query: 1903 VNYSIKTGN-ADEAVTIHPVTGSI---SVLNPAFLGLSRKL---TIRASDGLYQDTALVK 1955
++YS+ A + P TG+I ++L+ +R + T R S L +A +
Sbjct: 2206 ISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALV-GSATLT 2264
Query: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGT---DMF 2012
+ + D Q ++ L + + G + + + +++L+ + D F
Sbjct: 2265 VMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD--SGPVLWYVLSPSGPQDPF 2322
Query: 2013 HMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKH 2072
+ + G + G D EQ D ++L + D R + V +EDVNDN P F
Sbjct: 2323 SVGRYGGRVSLTG-PLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQ 2378
Query: 2073 LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISL---KK 2129
Y ++ + T PG + VSATD D G NG ++Y A F +DP G +
Sbjct: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTV 2438
Query: 2130 PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSN--PLFQSPYYKVRVPENITLY 2187
+ + + ARD G P + V V ++++++ P F +Y+V V E++
Sbjct: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
Query: 2188 TPILHTQARSPEGLR----LIYNIVEEEPLMLFTTDFK--------------TGVLTVTG 2229
+ +L +A +G R + Y+I+ +F + + G L +
Sbjct: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
Query: 2230 PLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288
PLD+ES T++ TV A D S V V V DVNDNPP F++ Y ++ E P
Sbjct: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
Query: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348
++ + ASD D G + V + + D S F+++ S+G + LD E Q +
Sbjct: 2619 AELLHVEASDADPGPHGLVRFTV--SSGDPSGLFELDESSGTLRLAHALDCETQARHQLV 2676
Query: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408
V+A D V + V D+ND+ P F +V+E G LV + AID D+
Sbjct: 2677 VQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
Query: 2409 RDTSRLEYLILS---GNQDRH-FFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRA 2463
RL Y +L G + R F +NSS+G + S+ L VGA+D G A
Sbjct: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSA 2795
Query: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINK 2523
+V V + T ++Y P F + ++ E A G + + A D+D G G + Y++
Sbjct: 2796 SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAT- 2854
Query: 2524 LASEKFSIN 2532
+S F IN
Sbjct: 2855 -SSPYFGIN 2862
Score = 298 bits (764), Expect = 6e-80
Identities = 323/1179 (27%), Positives = 497/1179 (42%), Gaps = 148/1179 (12%)
Query: 69 VRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE- 127
++YRI+ GD + F + G F +R L+REV ++ L I+A +
Sbjct: 1785 LQYRILDGDPSGAFVLD-LASGEFGTMRP---------LDREVEPAFQLRIEARDGGQPA 1834
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEF-YYA 186
L A + V +LD ND P F P+Y V + ED+P + + ++ A D D G N YY
Sbjct: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVV-- 244
+ F + P+SG + A L+ + V AVD G G L+ V
Sbjct: 1895 GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVD-------GAAAGPLSTTVSVT 1947
Query: 245 --------HVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDP 296
H P + P S AT+ + +GA + + G P
Sbjct: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTP 2007
Query: 297 GKHFKAIKSYARSNEF--SLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPP 354
+ SY S V++ + + ++ +L ARS +G L
Sbjct: 2008 PPG-TTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVG------LQG 2060
Query: 355 SKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN---LQYVLKPSSENVGFKLNAR 411
+F +A + E +PPG+ +V R A + Y + +E F +
Sbjct: 2061 EAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPS 2120
Query: 412 TGLITTTKL--MDFHDRAHYQLHIRTSPGQAS--TVVVIDIVDCNNHAPLFNRSSYDGTL 467
TG IT +DF +L ++ G A TV+ + + D N++AP F R Y L
Sbjct: 2121 TGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFL 2180
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDYELM 525
E+ P +L V A D D G G ++YS+A P F +DP G I+T+ +D E+
Sbjct: 2181 PESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIW 2240
Query: 526 KRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
+ A+D GSP ++ + + + NDN+P + + +D +G I
Sbjct: 2241 AET-RLVLMATDRGSP-ALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQ 2297
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
++ DVD L Y + + F + + G +SL P L Q Y L++ A DG
Sbjct: 2298 VTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGP---LDFEQCDRYQLQLLAHDG 2354
Query: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
+ N+TV+ +
Sbjct: 2355 PHEG---RANLTVLVE-------------------------------------------- 2367
Query: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
+N P F Q + +LE P + + ++ATD D+G NG + Y +A + F +
Sbjct: 2368 DVNDNAPAFSQSLYQ-VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSV 2424
Query: 766 ELETGLL-----TVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRF 820
+ G L TVA L ++ + + + D G P +++ + V ++D ND+AP F
Sbjct: 2425 DPNNGTLFTIVGTVA--LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSF 2482
Query: 821 PPGGYQLTISEDTEVGTTIAELTTKDAD-SEDNGRVRYTLLSPT--EKFSLHPLTGE--- 874
Y++ ++ED G+T+ L DAD S + V Y+++S F L P E
Sbjct: 2483 TLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
Query: 875 -----------LVVTGHLDRESEPRYILKVEARD--QPSKGHQLFSVTDLIITLEDVNDN 921
LV+ LD ES +Y L V A D QP + SV + +T+ DVNDN
Sbjct: 2543 SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS----SVVPVTVTVLDVNDN 2598
Query: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGA 980
P R+ VPED P G L ++ASD D GP G VR+ + G G F +D +G
Sbjct: 2599 PPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT 2658
Query: 981 LILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQ 1040
L L LD E +A + L + A+D A L V + V DVN+ H P F +
Sbjct: 2659 LRLAHALDCETQARHQLVVQAADPAG--AHFALAPVTIEVQDVND--HGPAFPLNLLSTS 2714
Query: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQY-FLRAG---TGLAAFSINQDTGMIQTLAPLD 1096
V EN P GT V + A D D+G G L+Y L AG G AF++N TG ++ P D
Sbjct: 2715 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFD 2774
Query: 1097 REFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV 1156
E + L V A D G+ LS+ V + VT ++ P F+ + E A G S+
Sbjct: 2775 YEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSL 2832
Query: 1157 LQLDAWDPDSSSKGKLTFNI-TSGNYMGFFMIHPVTGLL 1194
+ A D D + G + +++ TS Y G I+ TG L
Sbjct: 2833 GHVQATDEDGGADGLVLYSLATSSPYFG---INQTTGAL 2868
Score = 110 bits (276), Expect = 2e-23
Identities = 141/562 (25%), Positives = 243/562 (43%), Gaps = 63/562 (11%)
Query: 102 SNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDM 161
S T L+ E D Y L + A + E A V+V D ND P FS Y+V + E
Sbjct: 2332 SLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVE--DVNDNAPAFSQSLYQVMLLEHT 2389
Query: 162 PLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVV-TVAGKLNVTWRGKHELQ 220
P S I V+ATD D G N Y + ++ F++ P +G + T+ G + + G
Sbjct: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG--- 2446
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPA---------IASVVVTPPDSNDGTT 271
AVD + + + G A VHV+ + A +A PP S T
Sbjct: 2447 --AVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
Query: 272 YATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFS---------LVSVKDINW 322
AT D + S A V+ ++ G+ G+ F+ A + E + LV ++ +++
Sbjct: 2505 EATD-ADGSRSHAAVD-YSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
Query: 323 MEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLK-------FEKAVYRVQLSEFS 375
E L +NL++ A P S + P ++ L F +A YRV + E +
Sbjct: 2563 -ESLTQYNLTVAAADRGQPPQSSVV------PVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615
Query: 376 PPGSRVVMVRVTPAFPN----LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQL 431
P G+ ++ V + A P +++ + + F+L+ +G + +D +A +QL
Sbjct: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675
Query: 432 HIRTSPGQ----ASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH 487
++ + A V I++ D N+H P F + ++ EN PPGT V + A D D
Sbjct: 2676 VVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
Query: 488 GENGYVTYSI--AGP---KALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF 542
G G + YS+ AGP F+++ G + P DYE + + V A+D G+
Sbjct: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES-FRLLVGAADAGN-- 2792
Query: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYE 600
V++ + + ++ P+F + + G S+ + A D D + + Y
Sbjct: 2793 -LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS 2851
Query: 601 IVSGNELEYFDLNHFSGVISLK 622
+ + + YF +N +G + L+
Sbjct: 2852 LATSS--PYFGINQTTGALYLR 2871
Score = 76.6 bits (187), Expect = 5e-13
Identities = 78/287 (27%), Positives = 122/287 (42%), Gaps = 20/287 (6%)
Query: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYV--VG 90
FT SHY + E+ P + + + E + AV Y IISG+ VF+ E + G
Sbjct: 2482 FTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAG 2541
Query: 91 NFCFLRIRTKSSNTAL--LNREVRDSYTLIIQATEKTLELE-ALTRVVVHILDQNDLKPL 147
R L L+ E Y L + A ++ + ++ V V +LD ND P+
Sbjct: 2542 ESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPV 2601
Query: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQN--AEFYYAFNTRSEMFAIHPTSGVVTV 205
F+ SYRVT+ ED P+ + + V A+DAD G + F + S +F + +SG + +
Sbjct: 2602 FTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRL 2661
Query: 206 AGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAI------ASV 259
A L+ + +H+L V A D +LA + + V+ PA SV
Sbjct: 2662 AHALDCETQARHQLVVQAAD------PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSV 2715
Query: 260 VVTPPDSNDGTTYATVLVDANSSG-AEVESVEVVGGDPGKHFKAIKS 305
P TT + DA + G +E G G+ A+ S
Sbjct: 2716 AENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 660 bits (1703), Expect = 0.0
Identities = 672/2508 (26%), Positives = 1104/2508 (44%), Gaps = 266/2508 (10%)
Query: 1140 AVFYPSIQEDA-PVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGF-----FMIHPVTGL 1193
A+ + S +E+A PV + ++ A D DS G + +++ G ++ + F I P G
Sbjct: 61 AIVFRSQEENAKPVKET--EVTASDADSGLYGFIEYSLYDG-FLSYEAPQAFRIDPHDGQ 117
Query: 1194 LSTAQQLDREN-----------KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIF 1242
+ +Q +DRE KD +T L + L + + V V + DVNDN P+F
Sbjct: 118 ICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVF 177
Query: 1243 SHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYS-IEDSDEEAFSIDLVTGVVS 1301
+ + + + P + + ++A+D D G+ G V Y I + F+ID TG+ S
Sbjct: 178 NPSTYVTSISDETQPGT--EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
Query: 1302 SSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
E IL+ S + S+ + ++P R F + E
Sbjct: 236 P-------EVEILS-AVNFSADKEVMNSLEM---FLPLLR------HFKKVERDEEAAEK 278
Query: 1362 DPVNHMVGVISVEGRPGLFWFNISGGDKDMD--------FDIEKTTGS--IVIARPLDTR 1411
+ +GR L + + D ++ K G I + PL
Sbjct: 279 KFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHL 338
Query: 1412 RRSNYNLTVEVTDGSRTIA-----TQVHIFM--IANINHHRPQFLETRYEVRVPQDTVPG 1464
+ +L V DG A +HIF +A RP++ YE VP+D+ G
Sbjct: 339 ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIG 397
Query: 1465 VELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLT 1524
V+A + I+ S D G F + P G + T LD + P LT
Sbjct: 398 T----VKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRKPLDHETQPVV-VLT 450
Query: 1525 VMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADR 1584
V + P + V I V D N + P F + E + T PGT L RA D D
Sbjct: 451 VQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 509
Query: 1585 GVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQG-SPQWHDL 1643
G N + YS + G F I+ LG++ L L TLT++AEDQG PQ L
Sbjct: 510 GRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 568
Query: 1644 ATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA------MSPSEVTYELREG 1697
++ + F Y VE+ ES+ + +L A + S + Y L
Sbjct: 569 VLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
Query: 1698 NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAF---TDVMVVVDIIDENDN 1754
+F + Y+G I +++ D+E +Y ++ F V+V + DENDN
Sbjct: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDN 688
Query: 1755 APMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFK 1814
+P FL ++ E +P+ ++ K I A D D N L+Y +L KFFK
Sbjct: 689 SPTFLHDVLFLKVEE-SPVPQGVIGK------ITAIDMDSGKNGQLLYFLLSDG--KFFK 739
Query: 1815 IDPS---MGTLTIVS-----------------------------------------EMDY 1830
++P+ GT+ +++ +D
Sbjct: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPA--QVIIHVRDVNDSPPRF-----SEQIYEVAIVG 1883
E + V V D+GSP PR A V + V D+ND+ P F ++++ + G
Sbjct: 800 EHRGHHEMTVLVTDRGSP----PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 855
Query: 1884 -PIHPGMELLMVRASDE--DSEVNYSIKTGNADEAVTIHPVTGSI---SVLNPAFLGLSR 1937
P++ + + + DE ++EV YS+ + ++ + I G I ++L+ + R
Sbjct: 856 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYR 915
Query: 1938 KLTIRASDGL--YQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGN 1995
I G+ Q A+V I + + Q++ + ENL+ K + ++ + +
Sbjct: 916 MSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDH 975
Query: 1996 ---HLNDTLSYFLL--NGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQR 2050
H N L + ++ + F + S G L D E + V D+
Sbjct: 976 LQQHYNGKLHFSIVADDKDGHFEIDSSTGDL-FLSKELDYETTSHYLFRVITTDHSKNLS 1034
Query: 2051 VAQGL-VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
++ + + + +ED ND+ P F+ +++ G +++ +A D+D + +
Sbjct: 1035 LSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYY 1094
Query: 2110 AEDY----TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGT----PSLQS-EEEVL 2160
E + F I P G + D +++ L V A D L+S +++
Sbjct: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
Query: 2161 VTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLR---LIYNIVEEEPLMLFT 2217
+ N NP F S + V E++T+ + + H A P+ R + Y+I+ M F
Sbjct: 1155 ILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFM 1213
Query: 2218 TDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA-TVEVLVEDVNDNPPTFSQLV 2276
D +G+LT T PLDYE KT+H+ TV A D + S + T+ V V DVND P F Q +
Sbjct: 1214 LDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL 1273
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
Y S+ E V ++ A D+DSG N + ++I+ S + F+IN TGE+ T
Sbjct: 1274 YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS--FELFEINSDTGEVVTTTI 1331
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
LD E Q+ F ++V D G P L+ T ++ V D ND+ PEF Y+ V E
Sbjct: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PE 1390
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGA 2456
+V V A D D+ + +EY I+ GN D F IN SG +S + S++ L +
Sbjct: 1391 VVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
Query: 2457 S---DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPY 2513
S D + + + + +AN +SP F Y++ + E+A VGT V+ L A+DKD G
Sbjct: 1451 SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN 1510
Query: 2514 GTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD---GGGRVAFC 2569
G +Y + ++ AS F+I+P +G + T LDRE ++ + +ARD G R
Sbjct: 1511 GQTEYFLTDE-ASGAFTIDPMSGTLKTSNTLDREARSQHTFS--AVARDCSIQGSRSTTV 1567
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDL 2629
+K+ +TD NDN P + + + V + + + V A D D G N V +S
Sbjct: 1568 IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--- 1624
Query: 2630 VKDVIEINPVTGVVKVKDSLVGLENQTLDFF-----IKAQDGGPP--HWNSLVPVRLQVV 2682
+ + I+ TG ++ + +N + ++F +K D G P L+ + ++
Sbjct: 1625 TQSMFSIDKYTGEIQFQ------QNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE 1678
Query: 2683 PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVA---AQDPVIYSLVRGTTPESNKDGV 2739
K+S FS LY E+ G+ I VKA A QD + YS+ G N+DGV
Sbjct: 1679 DVKIS---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSG-----NEDGV 1730
Query: 2740 FSLDPDTGVIKVRKP--MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVF 2797
SL +G + V++P +D E Q+ V+A +++ + V + + D NDN P F
Sbjct: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLA---ESSGHRAYCKVAVLIQDENDNSPCF 1787
Query: 2798 EADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWI 2857
E Y+A ++E+ VIQV A D D+G +G + Y + + N E F ID+ SG I
Sbjct: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS---GNQEEAFQIDALSGVI 1844
Query: 2858 TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVE 2917
TT LD E +Y V A D G +LS+ +++V +TD NDNAP F E + E
Sbjct: 1845 TTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902
Query: 2918 NSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHT 2977
+S PG +V + D D++ + + + E +P +F I Q + + KTLD E
Sbjct: 1903 DSLPGVIVTHVSVHDVDLN--SAFIFSFAKESNPGTKFAIDQ--NTGVVVLVKTLDFEEM 1958
Query: 2978 AKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATD 3037
+Y L + SD + + VLDVNDN P SQ Y V E + G+ +L +SATD
Sbjct: 1959 TEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATD 2018
Query: 3038 LDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLT-ALDRERKDVFNLVAKATDGGGRSCQ 3096
L+++ N I+Y + + EF +DP G + T++ L + + +A+DGG +
Sbjct: 2019 LESNEN--ISYRILS-SSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
Query: 3097 A--DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPD-QGANAQVVYS-L 3152
A + + +ED+N+ AP F +++ ++ V + + D D N V YS +
Sbjct: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
Query: 3153 PDSAEGHFSIDA----------TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202
+++ +F ++ G + L L A EL + ASD G P PLS+
Sbjct: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP-PLSSTA 2194
Query: 3203 TVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG--YRVVSGNE 3260
+++ V+ + D P F + + V E P G+ + ++ R Y ++SGNE
Sbjct: 2195 VISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE 2254
Query: 3261 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQ 3320
+G F L+ TG+LY+ LD+E K+ L+++ S S V V++ D N+H PQ
Sbjct: 2255 KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSVLDDNDHAPQ 2313
Query: 3321 FPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGH--------FTIH 3372
F +S V EN + I +++A D D ++TYS++ L H F I
Sbjct: 2314 FMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLID 2373
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYS 3432
P G++ + LD E + Y L ++A D G + + + +++ P F Q Y
Sbjct: 2374 PLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT--ASLVVWVDIEGIDEFEPIFTQDQYF 2431
Query: 3433 TTVQENSPIGSKVLQLILSDPDSPENG----------PPYSFRITKGN 3470
T+ E + + ++ SD D+ +G P +S T GN
Sbjct: 2432 FTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN 2479
Score = 605 bits (1561), Expect = e-172
Identities = 664/2522 (26%), Positives = 1094/2522 (43%), Gaps = 267/2522 (10%)
Query: 841 ELTTKDADSEDNGRVRYTLLS------PTEKFSLHPLTGELVVTGHLDRESEPR-YILKV 893
E+T DADS G + Y+L + F + P G++ V+ +DRE +P Y L V
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 894 EARDQPSKGHQLFSVTD--------LIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT 945
EA+D + ++ + + LEDVNDN P + ++ PGT +
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 946 FLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDG 1004
+ A+D D G G V Y L+ G F +D TG E E+ + N S
Sbjct: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI----LSAVNFS------ 247
Query: 1005 GRPLARRTLCHVEVIVLDVNENLHP--PHFASFVHQGQVQENSPSGTQ-----------V 1051
+ V++ E P HF + E ++ +
Sbjct: 248 -----------ADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
Query: 1052 IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
+ QD+ + DGE A +A + G+I PL ++ L V A D
Sbjct: 297 HYLKVQDEAASADGEA-----AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQD 351
Query: 1112 RGSVPLSSVTEVYIEVTDANDNPPQMSQAVF----YPSIQEDAPVGTSVLQLDAWDPDSS 1167
G + +V I + P + + + Y + ED+P+GT + A +P +S
Sbjct: 352 GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAREPLNS 407
Query: 1168 SKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSR 1227
S+ + + I+SG+ G F IHP G + T + LD E + +L V P+ ST
Sbjct: 408 SE-PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE- 465
Query: 1228 VVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD 1287
V + ++DVNDN P F +R+ + P + +Y A D D G NG + YSI
Sbjct: 466 VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA--LYLARAEDRDSGRNGLIRYSIASPQ 523
Query: 1288 EEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSI 1345
F+ID GV+ + + AGE LT++A D G P +A + L + + R S
Sbjct: 524 PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV--VIEKREHSP 581
Query: 1346 PLAFDETYYSFTVMETDPVNHMVGVISVEGRP-------GLFWFNISGGDKDMDFDIEKT 1398
F+ Y V E+ ++ M ++ + P +++ F I
Sbjct: 582 SWTFEHLVYQVEVSES--LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
Query: 1399 TGSIVIARPLDTRRRSNYNLTVEV---TDGSRTIATQVHIFMIANINHHRPQFLETRYEV 1455
TG I + R D YN V DG + I + + N + P FL +
Sbjct: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFL 699
Query: 1456 RVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKL- 1512
+V + VP + ++ AID D GK+ L+Y + F+++P++G T+ +
Sbjct: 700 KVEESPVPQGVIGKITAIDMDSGKNGQLLYFL-----LSDGKFFKMNPNTGPAGTIYVIT 754
Query: 1513 ------------------------------DLGSGP------------SQHTLTVMVRDQ 1530
+LG G H +TV+V D+
Sbjct: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
Query: 1531 EIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE----LLQVRAMDADRGV 1586
P + + V + V D N + P F Q + + G + V A D D G
Sbjct: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
Query: 1587 NAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATV 1646
NAEV YS+ +S F I+A G I L + ++V A DQG P A V
Sbjct: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Query: 1647 IIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE---------VTYELREG 1697
I V P + I S++ + IPE++ P ++S + S+ + + +
Sbjct: 935 NIQVIPLSKGRAIMSQNIRHLIIPENL---KPTKIMSLIKSSDHLQQHYNGKLHFSIVAD 991
Query: 1698 NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDEND 1753
+KDG F ++S +G + K+LD+E S Y ++ N++ + T V + +D+ D+ND
Sbjct: 992 DKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST-VFLSIDVEDQND 1050
Query: 1754 NAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKE-ANSLLVYKI-LEPEALK 1811
++P F V + E P+ +++ +V +A D D NS + Y I
Sbjct: 1051 HSPSFQDELIVISVEENVPIGTLV-------YVFNAKDDDGSFLNSRIQYYIESHNPGTN 1103
Query: 1812 FFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL---FAPRPAQVIIHVRDVNDS 1868
F I PS GTL VS +D ES+P+ V DQ V AQ++I DVND
Sbjct: 1104 PFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVI--LDVNDH 1161
Query: 1869 PPRF----SEQIYEVAIVGPIHPGMELLMVRASDE--DSEVNYSIKTGNADEAVTIHPVT 1922
P F + + E VG + + + DE + +V YSI +GN + + +
Sbjct: 1162 NPTFISFPNAHVKEDVTVGSL---VHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESS 1218
Query: 1923 GSISVLNPAFLGLSRK--LTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAV 1977
G ++ P + + LT+ A D + + +++ V D++ F Q +Y A+V
Sbjct: 1219 GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
Query: 1978 KENLQDRKALVILGA--QGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQ 2033
KEN + + + A + + +N L + ++ G ++F + G + T + DRE Q
Sbjct: 1279 KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTI-LDREIQ 1337
Query: 2034 DTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVS 2093
+ L V VRD P + + ++ED ND+ P+F Y + + EP +V++ V
Sbjct: 1338 EVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVL 1396
Query: 2094 ATDEDLGTNGAVTYEFAEDYT--YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP 2151
A+D D G N AV Y + T F I+ G++S + D + ++ + L ++ D G P
Sbjct: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP 1456
Query: 2152 SLQS--EEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQA-RSPEGLR-LIYNI 2207
S +V V N +P F + YY+ V E+ + T +L A EGL
Sbjct: 1457 PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516
Query: 2208 VEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATV--EVLVEDV 2265
+ +E FT D +G L + LD E++++H F+ A D ++ TV +V V DV
Sbjct: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
Query: 2266 NDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
NDN P Q + +S P + + A D D G N V + E S F I+
Sbjct: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS----MFSID 1632
Query: 2326 GSTGEMSTVQELDYEAQQHFHV--KVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ 2383
TGE+ Q + ++F + +++ D+G P T L+V+++ D F
Sbjct: 1633 KYTGEIQFQQN---PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHL 1688
Query: 2384 YEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK 2443
Y+ V+E G ++ V+A PDS S ++Y I SGN+D + S SG +++
Sbjct: 1689 YKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKE--P 1745
Query: 2444 KHLD----SSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTK 2499
K LD + L V A RA V + + N SP F+Q +Y+A ++E+ +
Sbjct: 1746 KFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAH 1805
Query: 2500 VIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVM 2558
VI + A D DSG G I+Y+I++ E F I+ +G I T LD E ++ + ++
Sbjct: 1806 VIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQAT 1865
Query: 2559 ARDGGGRVAFCTV-KIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQN 2617
+ G R++ TV K+ +TD NDN P F SE V I + V V +D D N
Sbjct: 1866 DK-GMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVD--LN 1921
Query: 2618 ADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPV 2677
+ +S E I+ TGVV + +L E + I+ D +LV
Sbjct: 1922 SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-- 1979
Query: 2678 RLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA--VAAQDPVIYSLVRGTTPESN 2735
++V+ + P FS+ Y + PE +P G + + A + + + + Y ++ S+
Sbjct: 1980 -VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL-----SSS 2033
Query: 2736 KDGVFSLDPDTGVIKVRKP---MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
K+ FS+DP G I P +D ST + ++ A N D+ +L V I + D+N+
Sbjct: 2034 KE--FSIDPKNGTIFTISPVLLLDTISTTQFLVE--ASDGGNPDLRALTLVEIGIEDMNN 2089
Query: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDG-QVSYR-LSADPGSNVH---EL 2847
P F Y L+E+ VG++++ + ID D R+ V Y +S + +N H +
Sbjct: 2090 YAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKF 2149
Query: 2848 FAID---SESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAP 2904
F + + G++ L LD E ++ ++A D G LSS A++ + + D NDN P
Sbjct: 2150 FHSEYPYKQVGYLVLLHSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPP 2208
Query: 2905 RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ-VGDE 2963
F+S Y V E++ G + + D D + + ++ I G+ G F + + G
Sbjct: 2209 NFSSLSYHTHVKESTPLGSHITVVSANDRD-TGSHAEIIYNIISGNEKGHFYLEENTGVL 2267
Query: 2964 WRISSRKTLDREHTAKYLLRVTASDG--KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVH 3021
+ I K LD E K+ L V ASD K + V + VLD ND++PQ ++ V
Sbjct: 2268 YLI---KPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVP 2324
Query: 3022 EDVFPGHFILKVSATDLDTDTNAQITYSL-------HGPGAHE--FKLDPHTGELTTLTA 3072
E++ I ++A D D ++TYS+ HG F +DP TG++
Sbjct: 2325 ENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI 2384
Query: 3073 LDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPV 3132
LD E + + L +A D G + + + +E +++ P F + + + +
Sbjct: 2385 LDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLI 2444
Query: 3133 AVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPL-----QVRPQAPLELTV 3187
V A D D G + ++YSL S+ FS++ T G I L + L Q+ + LE+ +
Sbjct: 2445 GRVEASDADAGIDGVILYSLGTSSP-FFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKI 2503
Query: 3188 RA 3189
A
Sbjct: 2504 IA 2505
Score = 601 bits (1550), Expect = e-171
Identities = 616/2291 (26%), Positives = 1003/2291 (43%), Gaps = 228/2291 (9%)
Query: 323 MEYLHGFNLSLQARSGSGPYFYSQIRG---FHLPPSKLSSLKFEKAVYRVQLSEFSPPGS 379
+ +L LSL + G + I H+ + L+ +FE+ Y + E P S
Sbjct: 335 LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 394
Query: 380 RVVMVRVTPAFPNLQYVL-KPSSENVG--FKLNARTGLITTTKLMDFHDRA----HYQLH 432
+ V+ + + + + SS ++G F ++ R G I T K +D + Q
Sbjct: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 454
Query: 433 IRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGY 492
+ ++P +ST V I ++D N++ P F R+S + + + PPGT++ A DRD G NG
Sbjct: 455 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 514
Query: 493 VTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWG-SPFRREKEVSIF 551
+ YSIA P+ F+ID LG++ + + + + T +RA D G P +++
Sbjct: 515 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL-TLTLRAEDQGVHPQAALLVLTVV 573
Query: 552 LQLRNLNDN---QPMFEEVNCTGSIRQDWPVGKSIMTMS--AIDVDELQNLKYEIVSGNE 606
++ R + + + + +V + S+ P+ + + T + L+Y + +
Sbjct: 574 IEKREHSPSWTFEHLVYQVEVSESLS---PMTQMLQTQAHPLGPQRAASPLRYSLEPSVD 630
Query: 607 LEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEV 666
F + ++G I L+R F +Y S T N F V
Sbjct: 631 SAMFGIRPYTGWIYLRRQF---------------------DYESTQTYN--------FRV 661
Query: 667 PVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLE 726
+ G L + T++ + + N +P F H + V E
Sbjct: 662 FAWIPEDGFLQNVSTTVI-----------------VRVWDENDNSPTFL-HDVLFLKVEE 703
Query: 727 SVPINTPLARLAATDPDAGFNGKLVYVI------------------------ADG----- 757
S + ++ A D D+G NG+L+Y + ADG
Sbjct: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
Query: 758 --------NEEGCFDI-----ELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWK 804
+E F + EL G L LD E + + V V D G+P +++
Sbjct: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 823
Query: 805 LLTVNVKDWNDNAPRFP---PG-GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL 860
+ V+V D NDN P FP PG + + E V + + KD D +N V Y++
Sbjct: 824 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 883
Query: 861 S--PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQ---PSKGHQLFSVTDLIITL 915
S ++ F + GE+ T L + P Y + V A DQ P +G ++ +
Sbjct: 884 SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQG-------QAVVNI 936
Query: 916 EDVNDNSPQCITEHN--RLKVPEDLPPGTVLTFLDASDP-DLGPAGEVRY-VLMDGAHGT 971
+ + + + I N L +PE+L P +++ + +SD G++ + ++ D G
Sbjct: 937 QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996
Query: 972 FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPH 1031
F +D TG L L +ELD+E + Y + +D + L+ + + + V D N+ H P
Sbjct: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQND--HSPS 1054
Query: 1032 FASFVHQGQVQENSPSGTQVIVVAAQDDD-SGLDGELQYFLRA-GTGLAAFSINQDTGMI 1089
F + V+EN P GT V V A+DDD S L+ +QY++ + G F I+ G +
Sbjct: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTL 1114
Query: 1090 QTLAPLDREFASYYWLTVLAVDRG----SVPLSSVTEVYIEVTDANDNPPQMSQAVFYPS 1145
T++ LDRE LTV A D+ L S+T I + D ND+ P + +P+
Sbjct: 1115 VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLT-AQIVILDVNDHNPTF---ISFPN 1170
Query: 1146 --IQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRE 1203
++ED VG+ V + A DPD GK+T++I SGN FM+ +GLL+T LD E
Sbjct: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
Query: 1204 NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPV 1263
K +HIL V LD+G P+L S+ + V +LDVND P+F L+ + E +P V
Sbjct: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGE--FV 1288
Query: 1264 YRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTFTAGEYNILTIK--ATD 1320
R+ A D D G+N ++ + I + E F I+ TG V +++ + T++ D
Sbjct: 1289 TRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRD 1348
Query: 1321 SGQPPLSASVRL--HIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---G 1375
G P LS++ + +E P I ++D V+E + V++ + G
Sbjct: 1349 GGFPSLSSTTTILCTVEDENDHAPEFIVSSYD-----IEVLENQEPEVVYTVLASDMDAG 1403
Query: 1376 RPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVH 1434
++I G+ D F I + +G + R LD + SN+ L + +D G ++ +H
Sbjct: 1404 NNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIH 1463
Query: 1435 I-FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGS 1493
+ + + N H P F Y+ V +D G +L + A+D+D+G + T + D S
Sbjct: 1464 LQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN-GQTEYFLTDEAS 1522
Query: 1494 ASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRN-FVWVTIHVEDGNLHP 1552
+ F +DP SG L T LD SQHT + + RD I R+ V + ++V D N +
Sbjct: 1523 GA-FTIDPMSGTLKTSNTLD-REARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDND 1580
Query: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII 1612
P Q ++ + + VRA D D G N V +S ++ F+I+ G I
Sbjct: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEI 1638
Query: 1613 TLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPES 1672
Q + + P L +K DQG P ++IH+ D FS Y + E+
Sbjct: 1639 QFQQN-PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS-FSHHLYKGLVTEN 1696
Query: 1673 IPVGSPILLVSAMSPSEV----TYELREGNKDGVFSMNSYSGLISTQ--KKLDHEKISSY 1726
G+ I+ V A +P + Y + GN+DGV S+ S SG ++ + K LD E +
Sbjct: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756
Query: 1727 QLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFV 1786
QL + + +G V V I DENDN+P F +S + +SE + LY N +
Sbjct: 1757 QLIVLAES-SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSE-SQLY------NAHVIQ 1808
Query: 1787 IHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQG 1846
+ A+D D N L+ Y IL + F+ID G +T + +DYE S+ V D+G
Sbjct: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
Query: 1847 SPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYS 1906
P L + + V D+ND+ P F V I PG+ + V D D +
Sbjct: 1869 MPRL--SNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFI 1925
Query: 1907 I---KTGNADEAVTIHPVTGSISVLNPA-FLGLSR-KLTIRASDGLYQDTALVKISLTQV 1961
K N I TG + ++ F ++ +L I+ SD ++ + + + V
Sbjct: 1926 FSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDV 1985
Query: 1962 LDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVL 2021
D F QD Y V E++ +++ L A N+ +SY +L+ + F + G +
Sbjct: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTI 2045
Query: 2022 QTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQD 2081
T + T + VE D P A LV + IED+N+ P+F Y + +
Sbjct: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
Query: 2082 GTEPGDVLFQVSATDED-LGTNGAVTY---------EFAEDYTYFRID-PY--LGDISLK 2128
G L S D D N V Y F + +F + PY +G + L
Sbjct: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
Query: 2129 KPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITL 2186
D +A + L ++A D G P L S + + V N + P F S Y V E+ L
Sbjct: 2166 HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
Query: 2187 YTPILHTQARSPE---GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTV 2243
+ I A + +IYNI+ F + TGVL + PLDYE TK TV
Sbjct: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
Query: 2244 RATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
+A+D FS A V V V D ND+ P F ++ + E LP + + + A D D+G
Sbjct: 2286 QASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
Query: 2304 NRDVSYQIV------EDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDP 2357
+++Y IV S F I+ TG++ Q LDYE + + V+A DKGD
Sbjct: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD- 2404
Query: 2358 PLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL 2417
T +V V++ I++ P F Q QY + E L+ +V+A D D+ + Y
Sbjct: 2405 -ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS 2463
Query: 2418 ILSGNQDRHFFINSSSG---IISMFNLCKKHLDSSYNLRV------GASDGVFRATVPVY 2468
+ G F +N ++G +I L K L+ L + SD F A+ V+
Sbjct: 2464 L--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKF-ASCTVF 2520
Query: 2469 INTTNANKYSP 2479
+N + +++ +P
Sbjct: 2521 VNVSFSSEGTP 2531
Score = 596 bits (1537), Expect = e-169
Identities = 648/2599 (24%), Positives = 1066/2599 (41%), Gaps = 287/2599 (11%)
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSI-------AGPKALPFSIDPYLGIISTSKPM 520
+EN P VTA+D D G G++ YS+ P+A F IDP+ G I S+ +
Sbjct: 68 EENAKP-VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQA--FRIDPHDGQICVSQDI 124
Query: 521 DYELMKRIYTFRVRASDWGSPFRR----------EKEVSIFLQLRNLNDNQPMFEEVNCT 570
D E Y V A D G R + + + L ++NDN P+F
Sbjct: 125 DRERDPATYDLLVEAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 571 GSIRQDWPVGKSIMTMSAIDVDE--LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINL 628
SI + G I+ + A D D + YE++ GN F ++ +G+
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL---------- 233
Query: 629 TAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIG 688
YS ++ N+++ + L F + HF
Sbjct: 234 -------YSPEVEILSAVNFSADKEV------------------MNSLEMFLPLLRHFKK 268
Query: 689 LQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNG 748
++ E + E+ S + + H+ + D S A + A +
Sbjct: 269 VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAAS----------ADGEAAARYVA 318
Query: 749 KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTV 808
L ++ +G ++ + PL + + L V+ D G +T+
Sbjct: 319 NLAKILGEG-------------IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI 365
Query: 809 NVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDA-DSEDNGRVRYTLLSPTEKFS 867
++ F Y + ED + I + ++ +S + R + KFS
Sbjct: 366 HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFS 425
Query: 868 LHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCIT 927
+HP G + LD E++P +L V+A+ + S T++ IT+ DVNDN P +
Sbjct: 426 IHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA---CSSTEVNITVMDVNDNHPAFLR 482
Query: 928 EHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILEREL 987
+ +++ + PPGT L A D D G G +RY + G F +D G L L L
Sbjct: 483 TSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL 542
Query: 988 DFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPS 1047
+ L+L A D G + + V +V++ E+ F V+Q +V E+
Sbjct: 543 GAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 600
Query: 1048 GTQVIVVAAQD-DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLT 1106
TQ++ A L+Y L A F I TG I D E Y
Sbjct: 601 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
Query: 1107 VLA-VDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-QLDAWDP 1164
V A + + T V + V D NDN P V + + E++PV V+ ++ A D
Sbjct: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV-EESPVPQGVIGKITAIDM 719
Query: 1165 DSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQ-------------------------- 1198
DS G+L + + S FF ++P TG T
Sbjct: 720 DSGKNGQLLYFLLSDG--KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAF 777
Query: 1199 ------------------QLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPP 1240
LDRE++ H + V V D G P +T V V + D+NDN P
Sbjct: 778 VLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 837
Query: 1241 IFSHKLFNVRLPERLSPVSPGPVYRLV----ASDLDEGLNGRVTYSIEDSD-EEAFSIDL 1295
F L L + + PV LV A D DEG N VTYS+ D + F ID
Sbjct: 838 FFPQCLPGKEL--HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDA 895
Query: 1296 VTGVVSSSSTFTAGEYN---ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
G + ++T + +Y +++ ATD G PPL ++I+ IP + +I +
Sbjct: 896 NNGEI-RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAI---MSQN 951
Query: 1353 YYSFTVMETDPVNHMVGVISVEGR-----PGLFWFNISGGDKDMDFDIEKTTGSIVIARP 1407
+ E ++ +I G F+I DKD F+I+ +TG + +++
Sbjct: 952 IRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKE 1011
Query: 1408 LDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANI---NHHRPQFLETRYEVRVPQDTVPG 1464
LD S+Y V TD S+ ++ +F+ ++ N H P F + + V ++ G
Sbjct: 1012 LDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Query: 1465 VELLRVQAIDQDKG--KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHT 1522
+ A D D S I S +PG+ + F + PS G LVTV +LD S P+
Sbjct: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGT-NPFLIHPSFGTLVTVSRLDRESIPTV-I 1129
Query: 1523 LTVMVRDQEIPI---KRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRA 1579
LTV DQ + + + + I + D N H P F A V + + G+ + + A
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITA 1188
Query: 1580 MDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQ 1639
D D G N +V YS+L GN F ++ G++T LD H LTV A D G+P
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA 1248
Query: 1640 WHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMS-----PSEVTYEL 1694
T+ + V + AP+F + Y + E+ G + V A+ S++ +E+
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
Query: 1695 REGNKDGVFSMNSYSGLISTQKKLDHE--KISSYQLKIRGSNMAGAFTDVMVVVDIIDEN 1752
G +F +NS +G + T LD E ++ + ++ +R + ++ + DEN
Sbjct: 1309 MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN 1368
Query: 1753 DNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIH---ASDSDKEANSLLVYKILEPEA 1809
D+AP F+ S++ ++ E N P V++ ASD D N + Y I++
Sbjct: 1369 DHAPEFIVSSYDIEVLE-----------NQEPEVVYTVLASDMDAGNNRAVEYHIIDGNT 1417
Query: 1810 LKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVR--DVND 1867
+ F I+ G L+ +D E + +F + D G P PR + + + VR D ND
Sbjct: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP----PRSSVIHLQVRVLDAND 1473
Query: 1868 SPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK---TGNADEAVTIHPVTGS 1924
P F Y+ ++ G +L++ A D+D +N + T A A TI P++G+
Sbjct: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT 1533
Query: 1925 ISVLNP---------AFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWA 1975
+ N F ++R +I+ G T ++K+ +T V D +Q+ +
Sbjct: 1534 LKTSNTLDREARSQHTFSAVARDCSIQ---GSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
Query: 1976 AVKENLQDRKALVILGAQGNHL--NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQ 2033
+ + VI+ A L N T+ + MF + + G +Q +Q
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQF-------QQN 1643
Query: 2034 DTHE-----LAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088
+ E L ++V D P R GL+ + +E D F H Y ++ + E G
Sbjct: 1644 PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHLYKGLVTENCEAGTS 1702
Query: 2089 LFQVSATDEDLGTNGAVTYEF--AEDYTYFRIDPYLGDISLKKP--FDYQALNKYHLKVI 2144
+ V A D ++ Y + + G +++K+P D++ N+ L V+
Sbjct: 1703 IVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVL 1761
Query: 2145 ARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARS-PEGLR- 2202
A G + + VL+ N ++P F+ Y+ V E+ ++ A GL
Sbjct: 1762 AESSGHRA-YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNG 1820
Query: 2203 -LIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATV-EV 2260
+ Y+I+ F D +GV+T LDYE + + V+ATD + S TV +V
Sbjct: 1821 LIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKV 1880
Query: 2261 LVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK 2320
V D+NDN P F + LP VI S D N + ++ + +K
Sbjct: 1881 QVTDINDNAPAFLPSEAVEITEDSLPG---VIVTHVSVHDVDLNSAFIFSFAKESNPGTK 1937
Query: 2321 FFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFR 2380
F I+ +TG + V+ LD+E + + ++ D E +VV V D+NDNPP F
Sbjct: 1938 -FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFS 1993
Query: 2381 QPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG-IISMF 2439
Q Y+ V E G+ VL + A D +S + + Y ILS +++ F I+ +G I ++
Sbjct: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNE--NISYRILSSSKE--FSIDPKNGTIFTIS 2049
Query: 2440 NLCKKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMV 2496
+ S+ V ASDG RA V I + N Y+PEF Y L+E+A+V
Sbjct: 2050 PVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
Query: 2497 GTKVIDLLAIDKDSGPYGT-IDYTIINKLASEKFSINPN-----------GQIATLQKLD 2544
G+ ++ ID D T ++Y+II+ + F + G + L LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
Query: 2545 RENSTERVIAIKVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDS 2602
RE S + I +A D G T + I + D NDNPP F + Y ++ + S
Sbjct: 2170 REASASHELVI--LASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGS 2227
Query: 2603 PVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIK 2662
+ V A D D G +A++ Y++ + K + TGV+ + L + ++
Sbjct: 2228 HITVVSANDRDTGSHAEIIYNIISGN-EKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
Query: 2663 AQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AA 2718
A D H+ S V + V+ P+F ++ PE+LP S I + A+
Sbjct: 2287 ASDAEKKHF-SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
Query: 2719 QDPVIYSLVRG---TTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT 2775
+ YS+V T S +F +DP TG I ++ +D+E+ Y + V A
Sbjct: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK--DKG 2403
Query: 2776 DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYR 2835
D + + V + + +++ P+F D Y L E + +V A D D G DG + Y
Sbjct: 2404 DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS 2463
Query: 2836 LSADPGSNVHELFAIDSESGWITTLQELDCETCQ-----TYHFHVVAYDHGQTIQLSS-Q 2889
L F+++ +G I ++ L Q T ++A+ + +S
Sbjct: 2464 LGTS-----SPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCT 2518
Query: 2890 ALVQVSITDENDNAPRFAS 2908
V VS + E FAS
Sbjct: 2519 VFVNVSFSSEGTPLAVFAS 2537
Score = 514 bits (1325), Expect = e-145
Identities = 596/2485 (23%), Positives = 1035/2485 (41%), Gaps = 232/2485 (9%)
Query: 1266 LVASDLDEGLNGRVTYSIEDS-----DEEAFSIDLVTGVVSSSSTFTA------------ 1308
+ ASD D GL G + YS+ D +AF ID G + S
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
Query: 1309 ---GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVN 1365
G+ +T A G A VR+ +E + P P TY + ET P
Sbjct: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNP----STYVTSISDETQPGT 194
Query: 1366 HMVGVISVEGRPGLFW---FNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEV 1422
++ V++ + G++ + + G+ F I+ TTG + + ++ N++ EV
Sbjct: 195 EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG--LYSPEVEILSAVNFSADKEV 252
Query: 1423 TDGSRTIATQVHIFMIANINHHRPQFLETRYEVR----VPQDTVPGVELLRVQ--AIDQD 1476
+ + F + + E ++E + + L+VQ A D
Sbjct: 253 MNSLEMFLPLLRHFKKVERDE---EAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD 309
Query: 1477 KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR 1536
+ Y + ++ G ++ P S + T L + + V+ D
Sbjct: 310 GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD------- 362
Query: 1537 NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
VTIH+ L P F + Y V + + + + V+A + + + Y +
Sbjct: 363 ----VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNS-SEPIFYRISS 417
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ G F+I+ LG I + LD LTV+A+ +P V I V + +
Sbjct: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDN 476
Query: 1657 APIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGL 1711
P F ++ + I ++ P G+ + L A + Y + + GVF+++ G+
Sbjct: 477 HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGV 535
Query: 1712 ISTQKKLDHEKISSYQLKIRGSNMA-GAFTDVMVVVDIIDENDNAPMFLKSTFVGQI--S 1768
+ L + L +R + ++V+ +I++ +++P + V Q+ S
Sbjct: 536 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVS 595
Query: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEM 1828
E+ + ++ +P + A S L Y + F I P G + + +
Sbjct: 596 ESLSPMTQMLQTQAHPL------GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQF 649
Query: 1829 DYESMPSFQFCVY--VHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIH 1886
DYES ++ F V+ + + G VI+ V D ND+ P F + + +
Sbjct: 650 DYESTQTYNFRVFAWIPEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
Query: 1887 PGMELLMVRASDEDSEVN-----YSIKTG-------NADEAVTIHPVTGSIS-------- 1926
P + + A D DS N + + G N A TI+ +T +
Sbjct: 707 PQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTD 766
Query: 1927 -----------VLNPAFLGLSRKLTI------RASDGLYQDTALVK-------------- 1955
VL F L I R G ++ T LV
Sbjct: 767 FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 826
Query: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--------QGNHLNDTLSYFLLN 2007
+S+T + D F Q + + + + + + +L +GN+ T S +
Sbjct: 827 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSED 886
Query: 2008 GTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNP 2067
+D F + + G ++T + + + ++ ++V D P Q +V + + ++
Sbjct: 887 SSDHFKIDANNGEIRTTTI-LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945
Query: 2068 PKFKHLPYYTIIQDGTEPGDVLFQVSATDE-DLGTNGAVTYEFAEDYT--YFRIDPYLGD 2124
+ II + +P ++ + ++D NG + + D +F ID GD
Sbjct: 946 AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005
Query: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV----RNKSNPLFQSPYYKVRV 2180
+ L K DY+ + Y +VI D + +L V +++ +N +P FQ + V
Sbjct: 1006 LFLSKELDYETTSHYLFRVITTDH-SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
Query: 2181 PENITLYTPILHTQARSPEGL----RLIYNIVEEEP-LMLFTTDFKTGVLTVTGPLDYES 2235
EN+ + T + A+ +G R+ Y I P F G L LD ES
Sbjct: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
Query: 2236 KTKHVFTVRATDTALG----SFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPV 2291
+ TV A+D A+ T ++++ DVND+ PTF + E + + V
Sbjct: 1125 IPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLV 1183
Query: 2292 IQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRA 2351
+ A D D GRN V+Y I+ +++ F ++ S+G ++T LDYE + + V A
Sbjct: 1184 HHITAHDPDEGRNGKVTYSILSGNENMT--FMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
Query: 2352 MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDT 2411
+D G P L+ + V V D+ND P F+Q YEA+V E G V +V+A+D DS
Sbjct: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
Query: 2412 SRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVF---RATVPVY 2468
S+L++ I+ G F INS +G + + + + + LRV DG F +T +
Sbjct: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
Query: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528
+ N ++PEF Y+ E+ EN V +LA D D+G ++Y II+ E
Sbjct: 1362 CTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
Query: 2529 FSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKA 2587
F+IN +G+++T + LDRE + + I R + +++ + D ND+ P F
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKD 2647
Y S++ + + V+ + A D DEG N Y + E I+P++G +K +
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDE--ASGAFTIDPMSGTLKTSN 1538
Query: 2648 SLVGLENQTLDFFIKAQDGG-PPHWNSLVPVRLQVVPKKVSLPKFSE-PLYTFSAPEDLP 2705
+L F A+D ++ V +++ V + P + P F +PE P
Sbjct: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPES-P 1597
Query: 2706 EGSEIGIVKA----VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
IV+A + V++S + +FS+D TG I+ ++ E
Sbjct: 1598 TNQTTVIVRADDLDLGPNGTVVFSF-------AETQSMFSIDKYTGEIQFQQNPSSEYFP 1650
Query: 2762 LY-QIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
++ Q+ V + L+ ++++ DV + F YK ++TEN GTS++ V
Sbjct: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTSIVTVK 1707
Query: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQE--LDCETCQTYHFHVVAY 2878
A D+ +D S + S G N + ++ S+SG +T + LD E V+A
Sbjct: 1708 AFAPDSIQD---SMKYSIFSG-NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
G + V V I DENDN+P F Y+ SV E+ V + D D S
Sbjct: 1764 SSGH----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD-SGL 1818
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD---GKFQASV 2995
N + I G+ F I + I+++ LD E T+ Y L V A+D + +
Sbjct: 1819 NGLIEYSILSGNQEEAFQIDALSGV--ITTKAILDYELTSSYSLIVQATDKGMPRLSNTT 1876
Query: 2996 TVEIFVLDVNDNSPQC--SQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGP 3053
+++ V D+NDN+P S+ + ++ ED PG + VS D+D ++ +++
Sbjct: 1877 VIKVQVTDINDNAPAFLPSEAV---EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESN 1933
Query: 3054 GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRF 3113
+F +D +TG + + LD E + L+ + +D + + + V DVNDN P F
Sbjct: 1934 PGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGALVVRVLDVNDNPPVF 1992
Query: 3114 FPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK 3173
V V ++ V V + A D + +N + Y + S++ FSID G I
Sbjct: 1993 SQDFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSK-EFSIDPKNGTIFTIS 2049
Query: 3174 P-LQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAP 3232
P L + + + V ASD G P L L V + + + +Y P F +++ + EDA
Sbjct: 2050 PVLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
Query: 3233 PGTEVLQLATLTRPGAEK---TGYRVVSGNEQGRFRLDAR----------TGILYVNASL 3279
G+ ++ + + + Y ++SGN Q F ++ + G L + SL
Sbjct: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
Query: 3280 DFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDV 3339
D E S + L I S LS + + + DVN++ P F Y T V E+ +G
Sbjct: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH 2228
Query: 3340 ILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRAT 3399
I VSA D D +++I Y++I GN+ GHF + G L + K LD E+ + ++L ++A+
Sbjct: 2229 ITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
Query: 3400 DSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDS-PEN 3458
D+ + + + V D ND+ P+F ++S V EN PI S + + D D+ P
Sbjct: 2289 DA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYG 2347
Query: 3459 GPPYSF----RITKG--NNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL 3511
YS +T G + F + P G + + L Y L +QA D G
Sbjct: 2348 ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATA 2407
Query: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLA 3569
S + V + ++ + P + F T+ E ++G++ A+D D + YSL
Sbjct: 2408 SLVVWVDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG 2465
Query: 3570 EEETLGRHFSVGAPDGKIIAAQGLP 3594
T FSV +G I + LP
Sbjct: 2466 ---TSSPFFSVNKTNGNIYLIRALP 2487
Score = 511 bits (1316), Expect = e-144
Identities = 568/2193 (25%), Positives = 940/2193 (42%), Gaps = 263/2193 (11%)
Query: 134 VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNT--RS 191
V +HI F P Y + ED+P SPI V A + L + +Y ++
Sbjct: 363 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG 421
Query: 192 EMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALR 251
F+IHP G + L+ HE Q +V+ V+ L
Sbjct: 422 GKFSIHPRLGTIRTRKPLD------HETQ-------------------PVVVLTVQAQLG 456
Query: 252 KPPAIAS--VVVTPPDSNDG------TTYATVLVDANSSGAEVESVEVVGGDPGKHFKAI 303
PA +S V +T D ND T+ + G + D G++ I
Sbjct: 457 SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRN-GLI 515
Query: 304 KSYARSNEFSLVSVKDINWMEYLHG---------FNLSLQAR-SGSGPYFYSQIRGFHLP 353
+ S + + ++ + +L+G L+L+A G P + +
Sbjct: 516 RYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Query: 354 PSKLS-SLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN-----LQYVLKPSSENVGFK 407
+ S S FE VY+V++SE P ++++ + P P L+Y L+PS ++ F
Sbjct: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFG 635
Query: 408 LNARTGLITTTKLMDFHDRAHYQLHIRT---SPG---QASTVVVIDIVDCNNHAPLFNRS 461
+ TG I + D+ Y + G ST V++ + D N+++P F
Sbjct: 636 IRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHD 695
Query: 462 SYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIIST----- 516
++E+ P + +TA D D G+NG + Y + F ++P G T
Sbjct: 696 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGPAGTIYVIT 754
Query: 517 ----------------SKPMDYELMKRIY----------------------TFRVRASDW 538
S + ++K ++ V +D
Sbjct: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
Query: 539 GSPFRREKEVSIFLQLRNLNDNQPMFEEV----NCTGSIRQDWPVGKSIMTMSAIDVDEL 594
GSP R +++++ + ++NDN+P F + + + PV + T+ A D DE
Sbjct: 815 GSP-PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 873
Query: 595 QN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPT 652
N + Y + S + ++F ++ +G I R L+ SY + + A+D P
Sbjct: 874 NNAEVTYSVSSEDSSDHFKIDANNGEI---RTTTILSYDYRPSYRMSVIATD---QGVPP 927
Query: 653 TLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTP 712
VV + +V +++Q I H I +N + + + SL
Sbjct: 928 LQGQAVV---NIQVIPLSKGRAIMSQ---NIRHLIIPENLKPT--KIMSLI--------- 970
Query: 713 QFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLL 772
+ DH Q +NGKL + I +++G F+I+ TG L
Sbjct: 971 KSSDHLQQH------------------------YNGKLHFSIVADDKDGHFEIDSSTGDL 1006
Query: 773 TVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISE 831
++ LDYE T+ Y+ V D SS L+++V+D ND++P F +++ E
Sbjct: 1007 FLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEE 1066
Query: 832 DTEVGTTIAELTTKDAD-SEDNGRVRYTLLS---PTEKFSLHPLTGELVVTGHLDRESEP 887
+ +GT + KD D S N R++Y + S T F +HP G LV LDRES P
Sbjct: 1067 NVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIP 1126
Query: 888 RYILKVEARDQPSK--GHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT 945
IL V A DQ +L S+T I+ L DVND++P I+ N V ED+ G+++
Sbjct: 1127 TVILTVTASDQAVNVTDRRLRSLTAQIVIL-DVNDHNPTFISFPN-AHVKEDVTVGSLVH 1184
Query: 946 FLDASDPDLGPAGEVRYVLMDGAHG-TFRVDLMTGALILERELDFERRAGYNLSLWASDG 1004
+ A DPD G G+V Y ++ G TF +D +G L LD+E + + L++ A D
Sbjct: 1185 HITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDD 1244
Query: 1005 GRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLD 1064
G P A + + V VLDVN+ P F +++ V+EN G V V A D DSG++
Sbjct: 1245 GTP-ALSSSQTLTVTVLDVND--EAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
Query: 1065 GELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVY 1124
+LQ+ + G F IN DTG + T LDRE + L VL D G LSS T +
Sbjct: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
Query: 1125 IEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGF 1184
V D ND+ P+ + + + E+ V + A D D+ + + ++I GN
Sbjct: 1362 CTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F I+ ++G LST + LDRE L + D G+P S + V +LD ND+ P F
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 1245 KLF--NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
+ +VR + V V L A D DEGLNG+ Y + D AF+ID ++G + +
Sbjct: 1481 LYYQSSVREDAEVGTV----VLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKT 1536
Query: 1303 SSTF--TAGEYNILTIKATD---SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFT 1357
S+T A + + A D G + +++++ + P ++ +
Sbjct: 1537 SNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDVF 1591
Query: 1358 VMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRR 1413
+ P N ++ + G G F+ + + F I+K TG I + +
Sbjct: 1592 LSPESPTNQTTVIVRADDLDLGPNGTVVFSFA--ETQSMFSIDKYTGEIQFQQNPSSEYF 1649
Query: 1414 SNYNLTVEVTDGSRTIATQVHIFMIANINHH-RPQFLETRYEVRVPQDTVPGVELLRVQA 1472
+ L ++VTD T + +I + F Y+ V ++ G ++ V+A
Sbjct: 1650 PIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
Query: 1473 IDQDK-GKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQE 1531
D S+ Y+I + G SL SG L L +++ E
Sbjct: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCS---KSGQLTVKEPKFLDFEVRNEVQLIVL--AE 1763
Query: 1532 IPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVH 1591
R + V + ++D N + P F Q Y+ASV ++ ++QV A D D G+N +
Sbjct: 1764 SSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
Query: 1592 YSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVY 1651
YS+L GN E F I+AL G+IT LD + ++L V+A D+G P+ + + + V
Sbjct: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVT 1883
Query: 1652 PSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA----MSPSEVTYELREGNKDGVFSMNS 1707
+ +AP F SE VEI E G + VS ++ + + +E N F+++
Sbjct: 1884 DINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQ 1942
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQI 1767
+G++ K LD E+++ Y+L I+ S+ +T+ +VV ++D NDN P+F + + +
Sbjct: 1943 NTGVVVLVKTLDFEEMTEYELLIQISDSV-HYTEGALVVRVLDVNDNPPVFSQDFYQVTV 2001
Query: 1768 SEAAPL-YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTL-TIV 1825
E+ P+ YS V+ S +D E+N + Y+IL + K F IDP GT+ TI
Sbjct: 2002 PESIPVGYS----------VLTLSATDLESNENISYRIL--SSSKEFSIDPKNGTIFTIS 2049
Query: 1826 SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPI 1885
+ +++ + QF V D G+P L A V I + D+N+ P F+ + Y +++
Sbjct: 2050 PVLLLDTISTTQFLVEASDGGNPDLRA--LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA 2107
Query: 1886 HPGMELLMVRASD-----EDSEVNYSIKTGNADEAVTI----------HPVTGSISVLN- 1929
G L+ D E++ V YSI +GN+ + + G + +L+
Sbjct: 2108 LVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
Query: 1930 -PAFLGLSRKLTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRK 1985
S +L I ASD TA++ I + V D F Y VKE+
Sbjct: 2168 LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGS 2227
Query: 1986 ALVILGAQ----GNHLNDTLSYFLLNGTDM--FHMVQSAGVLQTRGVAFDREQQDTHELA 2039
+ ++ A G+H + Y +++G + F++ ++ GVL D E+ L
Sbjct: 2228 HITVVSANDRDTGSHAE--IIYNIISGNEKGHFYLEENTGVLYLI-KPLDYEKMTKFTLT 2284
Query: 2040 VEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDL 2099
V+ D + + +V VS+ D ND+ P+F + I+ + + ++A D D
Sbjct: 2285 VQASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA 2343
Query: 2100 GTNGAVTYEFAE----------DYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
G G +TY D+ F IDP GDI K+ DY+ NKY L V A+D G
Sbjct: 2344 GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
Query: 2150 TPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPE 2182
+ V + ++ P+F Y +PE
Sbjct: 2404 DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPE 2436
Score = 494 bits (1273), Expect = e-139
Identities = 512/2023 (25%), Positives = 852/2023 (42%), Gaps = 241/2023 (11%)
Query: 28 SSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEY 87
S +W F H Y + E+ SP T + + + +RY + + +F Y
Sbjct: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
Query: 88 VVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL 147
+ +LR + +T N + + E T V+V + D+ND P
Sbjct: 640 T--GWIYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 691
Query: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSG------ 201
F + + E + I K+TA D D G+N + Y + + F ++P +G
Sbjct: 692 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIY 751
Query: 202 VVTVA--------------------------------GKLNVTW-------RGKHELQVL 222
V+T A G+L + W RG HE+ VL
Sbjct: 752 VITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL-INWVALDREHRGHHEMTVL 810
Query: 223 AVDR--------------MRKISEGNGF--GSLAALVVHVEPALRKPPAIASVVVTPPDS 266
DR + I++ F L +HV+ +P + V D
Sbjct: 811 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDP 870
Query: 267 NDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYL 326
++G + AEV + V D HFK + +++S +Y
Sbjct: 871 DEG------------NNAEV-TYSVSSEDSSDHFKIDANNGEIRTTTILSY------DYR 911
Query: 327 HGFNLSLQARSGSGPYFYSQ-IRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR 385
+ +S+ A P Q + + P + + + + E P + +++
Sbjct: 912 PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIK 971
Query: 386 VTPAFPN-----LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ- 439
+ L + + ++ F++++ TG + +K +D+ +HY + T+
Sbjct: 972 SSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSK 1031
Query: 440 ----ASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHG-ENGYV 493
+STV + ID+ D N+H+P F +++EN+P GT V A D D N +
Sbjct: 1032 NLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRI 1091
Query: 494 TYSIA--GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF--RREKEVS 549
Y I P PF I P G + T +D E + + V ASD RR + ++
Sbjct: 1092 QYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTV-ILTVTASDQAVNVTDRRLRSLT 1150
Query: 550 IFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLK--YEIVSGNEL 607
+ + ++ND+ P F +++D VG + ++A D DE +N K Y I+SGNE
Sbjct: 1151 AQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNEN 1209
Query: 608 EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYA--SPTTLNITVVKDPHFE 665
F L+ SG+++ P L T + L + A D A S TL +TV+
Sbjct: 1210 MTFMLDESSGLLTTTCP---LDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL------ 1260
Query: 666 VPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVL 725
+N P F+ H ++ V
Sbjct: 1261 ----------------------------------------DVNDEAPVFKQHLYEA-SVK 1279
Query: 726 ESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNF 785
E+ + R+ A D D+G N KL + I G F+I +TG + LD E
Sbjct: 1280 ENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEV 1339
Query: 786 YILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTK 845
+ L V V D G P SS + V+D ND+AP F Y + + E+ E L +
Sbjct: 1340 FTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLAS- 1398
Query: 846 DADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARD--QPSK 901
D D+ +N V Y ++ + E F+++ ++GEL T LDRE + L + D P +
Sbjct: 1399 DMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPR 1458
Query: 902 GHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVR 961
SV L + + D ND+SP T + + V ED GTV+ L A D D G G+
Sbjct: 1459 S----SVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTE 1514
Query: 962 YVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021
Y L D A G F +D M+G L LD E R+ + S A D +R T ++V V
Sbjct: 1515 YFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVT 1574
Query: 1022 DVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFS 1081
DVN+N P + SP+ ++V A D D G +G + + + FS
Sbjct: 1575 DVNDN--DPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM--FS 1630
Query: 1082 INQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV 1141
I++ TG IQ E+ WL + D+G +P + T + + + D S +
Sbjct: 1631 IDKYTGEIQFQQNPSSEYFP-IWLQLKVTDQG-IPARTTTGLLVIHMEGEDVKISFSHHL 1688
Query: 1142 FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ-- 1199
+ + E+ GTS++ + A+ PD S + + ++I SGN G + +G L+ +
Sbjct: 1689 YKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKF 1747
Query: 1200 LDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS 1259
LD E ++E L V +G ++ +V V I D NDN P F ++ + E S +
Sbjct: 1748 LDFEVRNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSE--SQLY 1802
Query: 1260 PGPVYRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILT 1315
V ++ A+DLD GLNG + YSI + EEAF ID ++GV+++ + Y+++
Sbjct: 1803 NAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI- 1861
Query: 1316 IKATDSGQPPLSAS--VRLHIEWIPWPRPSSIPL-AFDETYYSFTVMETDPVNHMVGVIS 1372
++ATD G P LS + +++ + I P+ +P A + T S + V H V V
Sbjct: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGV---IVTH-VSVHD 1917
Query: 1373 VEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQ 1432
V+ + + F I++ TG +V+ + LD + Y L ++++D S
Sbjct: 1918 VDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEG 1976
Query: 1433 VHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPG 1492
+ + ++N + P F + Y+V VP+ G +L + A D + +++ Y I
Sbjct: 1977 ALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI-----LS 2031
Query: 1493 SASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP 1552
S+ F +DP +G + T+ + L S V D P R V I +ED N +
Sbjct: 2032 SSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYA 2091
Query: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDAD-RGVNAEVHYSLLKGNSEGFFNINA---- 1607
P FT Y S+ + G+ L+ +D D N V YS++ GNS+ F++
Sbjct: 2092 PEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFH 2151
Query: 1608 ------LLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFS 1661
+G + L LD+ A H L + A D G P A + I V + + P FS
Sbjct: 2152 SEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFS 2211
Query: 1662 KSEYFVEIPESIPVGSPILLVSAM-----SPSEVTYELREGNKDGVFSMNSYSGLISTQK 1716
Y + ES P+GS I +VSA S +E+ Y + GN+ G F + +G++ K
Sbjct: 2212 SLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK 2271
Query: 1717 KLDHEKISSYQLKIRGSNMAGA-FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775
LD+EK++ + L ++ S+ F+ +V V ++D+ND+AP F+ S+F + E P+ S
Sbjct: 2272 PLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
Query: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEAL--------KFFKIDPSMGTLTIVSE 1827
I I+A D D L Y I+ P L F IDP G +
Sbjct: 2332 TICS-------INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI 2384
Query: 1828 MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHP 1887
+DYE+ + V D+G A V + + +++ P F++ Y +
Sbjct: 2385 LDYENGNKYCLTVQAKDKGD----ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD 2440
Query: 1888 GMELLMVRASDEDSEVNYSI--KTGNADEAVTIHPVTGSISVL 1928
+ V ASD D+ ++ I G + +++ G+I ++
Sbjct: 2441 RQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLI 2483
Score = 354 bits (908), Expect = 1e-96
Identities = 403/1473 (27%), Positives = 637/1473 (43%), Gaps = 136/1473 (9%)
Query: 2244 RATDTAL---GSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
R T AL G ++A V V +EDVNDN P F+ Y TSIS+ T +I +LA+DQD
Sbjct: 146 RMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD 205
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDP--P 2358
SG V+Y+++ +VS F I+ +TG S E++ + +F M+ + P
Sbjct: 206 SGIYGTVAYELIP--GNVSSLFTIDSTTGLYSP--EVEILSAVNFSADKEVMNSLEMFLP 261
Query: 2359 LTGETLVVVNVSDINDNPPEFRQPQYEAN---VSELATCGHL-VLKVQAIDPDSRDTSRL 2414
L V + E + ++EA+ HL LKVQ + +
Sbjct: 262 LLRHFKKV-------ERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAA 314
Query: 2415 EYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSS-YNLRVGASDG-----VFRATVPVY 2468
Y+ + GII + L HL+S+ +L V A DG V A V ++
Sbjct: 315 RYVA-------NLAKILGEGIIYL-TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 366
Query: 2469 INTTN---ANKYSPEFQQHLYEAELAENAMVGT-KVIDLLAIDKDSGPYGTIDYTIINKL 2524
I T A P++ +YE ++ E++ +GT K + L S P I Y I +
Sbjct: 367 IFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGTVKAREPL---NSSEP---IFYRISSGD 419
Query: 2525 ASEKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCT-VKIILTDENDNP 2582
KFSI+P G I T + LD E T+ V+ + V A+ G T V I + D NDN
Sbjct: 420 LGGKFSIHPRLGTIRTRKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNH 477
Query: 2583 PQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV-NPEDLVKDVIEINPVTG 2641
P F + + I + + A D D G+N + YS+ +P+ V I+ G
Sbjct: 478 PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP---GVFAIDRALG 534
Query: 2642 VVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPK--FSEPLYTFS 2699
V+ + SL E + L ++A+D G H + + V V+ K+ P F +Y
Sbjct: 535 VLFLNGSLGAGEQRELTLTLRAEDQGV-HPQAALLVLTVVIEKREHSPSWTFEHLVYQVE 593
Query: 2700 APEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
E L +++ +A S +R + S +F + P TG I +R+ D+ES
Sbjct: 594 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 653
Query: 2760 TKLYQIDVMAHCLQNTDVVSL-VSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI- 2817
T+ Y V A ++ + ++ +V ++V D NDN P F D + E PV VI
Sbjct: 654 TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVL-FLKVEESPVPQGVIG 712
Query: 2818 QVTAIDKDTGRDGQVSYRLSAD-----------PGSNVHEL-------------FAIDSE 2853
++TAID D+G++GQ+ Y L +D P ++ + FA S+
Sbjct: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
Query: 2854 SGWITTLQELDCETCQTYHFHVVAYD------HGQTIQLSSQA--------LVQVSITDE 2899
L+ L CE + + VA D H T+ ++ + V VS+TD
Sbjct: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 832
Query: 2900 NDNAPRFAS----EEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQF 2955
NDN P F +E V+E LV T+ D D N +VT ++ D F
Sbjct: 833 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYSVSSEDSSDHF 891
Query: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCS 3012
I E R ++ L ++ Y + V A+D Q V I V+ ++ S
Sbjct: 892 KIDANNGEIRTTT--ILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS 949
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATD-LDTDTNAQITYSLHGPGAH-EFKLDPHTGELTTL 3070
Q + + E++ P + + ++D L N ++ +S+ F++D TG+L
Sbjct: 950 QNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLS 1009
Query: 3071 TALDRERKDVFNLVAKATDGGGR---SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTT 3127
LD E + TD S +++ VED ND++P F ++V +N
Sbjct: 1010 KELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVP 1069
Query: 3128 VKTPVAVVFARDPDQG-ANAQVVYSLPDSAEGH--FSIDATTGVIRLEKPLQVRPQAPLE 3184
+ T V V A+D D N+++ Y + G F I + G + L +
Sbjct: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
Query: 3185 LTVRASDLGTPIPLSTLGTVTVSVVGLE--DYLPVFLNTEHSVQVPEDAPPGTEVLQLAT 3242
LTV ASD + L ++T +V L+ D+ P F++ ++ V ED G+ V + T
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHI-T 1187
Query: 3243 LTRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS 3299
P + G Y ++SGNE F LD +G+L LD+E ++ L++ +
Sbjct: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247
Query: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
+LS T+ V + DVN+ P F Q Y V EN G+ + V A D D +NS + +
Sbjct: 1248 ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE 1307
Query: 3360 LIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADV 3419
++ G F I+ GE+ LDRE ++L++ D G P L T I V D
Sbjct: 1308 IMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDE 1367
Query: 3420 NDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP 3479
ND+ P F +Y V EN +V+ +L+ N + I GN F +
Sbjct: 1368 NDHAPEFIVSSYDIEVLENQE--PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
Query: 3480 -DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFI 3538
G L T L R + L I SD G PP SS+ ++V V + + ++PS L
Sbjct: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
Query: 3539 TVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGL--- 3593
+V ED G +V + A D+D Y L +E + F++ G + + L
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS--GAFTIDPMSGTLKTSNTLDRE 1543
Query: 3594 PRGHYSFNVTVSD----GTFTTTAGVHVYVWHV 3622
R ++F+ D G+ +TT + VYV V
Sbjct: 1544 ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
Score = 325 bits (833), Expect = 6e-88
Identities = 374/1471 (25%), Positives = 631/1471 (42%), Gaps = 165/1471 (11%)
Query: 107 LNREVRDSYTLIIQATEKTLE-----LEALTRVVVHILDQNDLKPLF-SPPSYRVTISED 160
L+RE + L + A+++ + L +LT +V ILD ND P F S P+ V ED
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTFISFPNAHV--KED 1176
Query: 161 MPLKSPICKVTATDADLGQNAEFYYAFNTRSE--MFAIHPTSGVVTVAGKLNVTWRGKHE 218
+ + S + +TA D D G+N + Y+ + +E F + +SG++T L+ + +H
Sbjct: 1177 VTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHI 1236
Query: 219 LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278
L VLA+D + ++ L V+ E + K + V + + T L D
Sbjct: 1237 LTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEAL-D 1295
Query: 279 ANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSG 338
+S E++ PG F+ + + + E ++ D E F L + R G
Sbjct: 1296 RDSGVNSKLQFEIM---PGASFELFEINSDTGEVVTTTILDREIQEV---FTLRVLVRDG 1349
Query: 339 SGPYFYS--------QIRGFHLPPSKLSSLKFE-------KAVYRVQLSEFSPPGSRVVM 383
P S + H P +SS E + VY V S+ +R V
Sbjct: 1350 GFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAV- 1408
Query: 384 VRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS----PGQ 439
+Y + + + F +N +G ++TT+ +D +++ L I S P +
Sbjct: 1409 ----------EYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPR 1458
Query: 440 ASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA 498
+S + + + ++D N+H+P F Y ++ E+ GT VL ++A D+D G NG Y +
Sbjct: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518
Query: 499 GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
+ F+IDP G + TS +D E + +TF A D R V I + + ++N
Sbjct: 1519 DEASGAFTIDPMSGTLKTSNTLDREARSQ-HTFSAVARDCSIQGSRSTTVIIKVYVTDVN 1577
Query: 559 DNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGV 618
DN P+ E+ + + P ++ + + A D+D N F ++ ++G
Sbjct: 1578 DNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE 1637
Query: 619 ISLKRPFINLTAGQ-PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLT 677
I ++ N ++ P LK+T + + TT + V+
Sbjct: 1638 IQFQQ---NPSSEYFPIWLQLKVT---DQGIPARTTTGLLVI------------------ 1673
Query: 678 QFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARL 737
+ E D + + F H + + V E+ T + +
Sbjct: 1674 -------------HMEGEDVKIS-------------FSHHLYKGL-VTENCEAGTSIVTV 1706
Query: 738 AATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAP--LDYEATNFYILNVTVYDL 795
A PD+ + Y I GNE+G + ++G LTV P LD+E N L V
Sbjct: 1707 KAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS 1765
Query: 796 GTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRV 855
G ++ + V ++D NDN+P F YQ ++SE + ++ D DS NG +
Sbjct: 1766 G---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLI 1822
Query: 856 RYTLLS--PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI- 912
Y++LS E F + L+G + LD E Y L V+A D KG S T +I
Sbjct: 1823 EYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRLSNTTVIK 1879
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTF 972
+ + D+NDN+P + +++ ED PG ++T + D DL A + F
Sbjct: 1880 VQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF 1938
Query: 973 RVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHF 1032
+D TG ++L + LDFE Y L + SD T + V VLDVN+N PP F
Sbjct: 1939 AIDQNTGVVVLVKTLDFEEMTEYELLIQISDS----VHYTEGALVVRVLDVNDN--PPVF 1992
Query: 1033 ASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTL 1092
+ +Q V E+ P G V+ ++A D L+ R + FSI+ G I T+
Sbjct: 1993 SQDFYQVTVPESIPVGYSVLTLSATD----LESNENISYRILSSSKEFSIDPKNGTIFTI 2048
Query: 1093 AP-LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAP 1151
+P L + S V A D G+ L ++T V I + D N+ P+ + + S+ EDA
Sbjct: 2049 SPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
Query: 1152 VGTSVLQLDAWDPDSSSKGK-LTFNITSGNYMGFFMI----------HPVTGLLSTAQQL 1200
VG++++ D D + + + ++I SGN F + + G L L
Sbjct: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
Query: 1201 DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP 1260
DRE H L + D+G P L ST+ + + +LDVNDNPP FS ++ + E S
Sbjct: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE--STPLG 2226
Query: 1261 GPVYRLVASDLDEGLNGRVTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGEYN--ILTIK 1317
+ + A+D D G + + Y+I +E+ F ++ TGV+ + LT++
Sbjct: 2227 SHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
Query: 1318 ATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
A+D+ + S +V ++ + F + +S V E P++ + I+
Sbjct: 2287 ASDAEKKHFSFAV----VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD 2342
Query: 1374 EGRPGLFWFNI-------SGGDKDMD-FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG 1425
G G ++I G D D F I+ TG I + LD + Y LTV+ D
Sbjct: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDK 2402
Query: 1426 SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIY 1483
A+ V I I+ P F + +Y +P+ + RV+A D D G ++Y
Sbjct: 2403 GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
Query: 1484 TIHGSQDPGSASLFQLDPSSGVLVTVGKLDL 1514
++ G+ P F ++ ++G + + L L
Sbjct: 2463 SL-GTSSP----FFSVNKTNGNIYLIRALPL 2488
Score = 266 bits (681), Expect = 3e-70
Identities = 311/1237 (25%), Positives = 523/1237 (42%), Gaps = 148/1237 (11%)
Query: 33 FTHSHYNATIYENSSPKT-YVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGN 91
F S Y+ + EN P+ Y M A AV Y II G+ F E
Sbjct: 1374 FIVSSYDIEVLENQEPEVVYTVLASDMD---AGNNRAVEYHIIDGNTDECFTINE----- 1425
Query: 92 FCFLRIRTKSSNTALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSP 150
+ + S T L+RE ++TL+I ++ ++ + V +LD ND P F
Sbjct: 1426 -----MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 151 PSYRVTISEDMPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIHPTSGVVTVAGKL 209
Y+ ++ ED + + + ++A D D G N + Y+ + S F I P SG + + L
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
Query: 210 NVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHV------EPALRKPPAIASVVVTP 263
+ R +H +A R S + + V+V +P L + P V ++P
Sbjct: 1541 DREARSQHTFSAVA----RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPF--DVFLSP 1594
Query: 264 PDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDIN-- 321
+ TT V+V A+ V + +I Y +F +
Sbjct: 1595 ESPTNQTT---VIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPI 1651
Query: 322 WMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRV 381
W++ L + + AR+ +G + H+ + + F +Y+ ++E G+ +
Sbjct: 1652 WLQ-LKVTDQGIPARTTTG------LLVIHMEGEDVK-ISFSHHLYKGLVTENCEAGTSI 1703
Query: 382 VMVRV---TPAFPNLQYVLKPSSENVGFKLNARTGLITTT--KLMDFHDRAHYQLHI--R 434
V V+ +++Y + +E+ L +++G +T K +DF R QL +
Sbjct: 1704 VTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
Query: 435 TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVT 494
+S +A V + I D N+++P F +S Y ++ E+ V+ V ATD D G NG +
Sbjct: 1764 SSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
Query: 495 YSI-AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQ 553
YSI +G + F ID G+I+T +DYEL Y+ V+A+D G P R I +Q
Sbjct: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSS-YSLIVQATDKGMP-RLSNTTVIKVQ 1881
Query: 554 LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIV-SGNELEYFDL 612
+ ++NDN P F I +D G + +S DVD + N F +
Sbjct: 1882 VTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
Query: 613 NHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDK 672
+ +GV+ L + L + T Y L I SD +Y
Sbjct: 1941 DQNTGVVVLVK---TLDFEEMTEYELLIQISDSVHYTE---------------------- 1975
Query: 673 TGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINT 732
G L + +N P F F Q + V ES+P+
Sbjct: 1976 -GALV------------------------VRVLDVNDNPPVFSQDFYQ-VTVPESIPVGY 2009
Query: 733 PLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAP---LDYEATNFYILN 789
+ L+ATD ++ N + Y I ++E F I+ + G + +P LD +T +++
Sbjct: 2010 SVLTLSATDLES--NENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065
Query: 790 VTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDAD- 848
+ D G P + L+ + ++D N+ AP F Y L++SED VG+T+ + D D
Sbjct: 2066 AS--DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW 2123
Query: 849 SEDNGRVRYTLLSPTEKFSLHPLT------------GELVVTGHLDRESEPRYILKVEAR 896
+ +N V Y+++S + + H T G LV+ LDRE+ + L + A
Sbjct: 2124 TRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILAS 2183
Query: 897 DQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGP 956
D S L S + I + DVNDN P + V E P G+ +T + A+D D G
Sbjct: 2184 D--SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGS 2241
Query: 957 AGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCH 1015
E+ Y ++ G G F ++ TG L L + LD+E+ + L++ ASD ++
Sbjct: 2242 HAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA----EKKHFSF 2297
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY------ 1069
V V +++N H P F V EN P + + + A D D+G GEL Y
Sbjct: 2298 AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPC 2357
Query: 1070 FLRAGTGL--AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
FL G F I+ TG I LD E + Y LTV A D+G S V V++++
Sbjct: 2358 FLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLV--VWVDI 2415
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMI 1187
++ P +Q ++ ++ E + +++A D D+ G + +++ G FF +
Sbjct: 2416 EGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSV 2473
Query: 1188 HPVTG---LLSTAQQLDRENKDEHILEVTVLDNGEPS 1221
+ G L+ + + E LE+ ++ + S
Sbjct: 2474 NKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKS 2510
Score = 67.0 bits (162), Expect = 4e-10
Identities = 61/213 (28%), Positives = 95/213 (44%), Gaps = 15/213 (7%)
Query: 26 LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85
+++ A FT YN ++ E++ + + +F + V Y IISG+ N F E
Sbjct: 2087 MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146
Query: 86 ------EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVV-VHI 138
EY +L + L+RE S+ L+I A++ + T V+ + +
Sbjct: 2147 TKFFHSEYPYKQVGYLVLLHS------LDREASASHELVILASDSGCPPLSSTAVISIQV 2200
Query: 139 LDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM--FAI 196
LD ND P FS SY + E PL S I V+A D D G +AE Y + +E F +
Sbjct: 2201 LDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYL 2260
Query: 197 HPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRK 229
+GV+ + L+ K L V A D +K
Sbjct: 2261 EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK 2293
Score = 65.5 bits (158), Expect = 1e-09
Identities = 53/171 (30%), Positives = 77/171 (45%), Gaps = 19/171 (11%)
Query: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG----TGLAAFSINQDTGMIQTLAPLDR 1097
QE + + V A D DSGL G ++Y L G AF I+ G I +DR
Sbjct: 67 QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126
Query: 1098 EF--ASYYWL-----------TVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYP 1144
E A+Y L T LA+ +G LS+ V +++ D NDN P + + +
Sbjct: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVT 184
Query: 1145 SIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLS 1195
SI ++ GT ++ + A D DS G + + + GN F I TGL S
Sbjct: 185 SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
Score = 53.9 bits (128), Expect = 3e-06
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 17/127 (13%)
Query: 406 FKLNARTGLITTTKLMDFH-DRAHYQLHIRTSPGQ---------------ASTVVVIDIV 449
F+++ G I ++ +D D A Y L + G A V +D+
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
Query: 450 DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYS-IAGPKALPFSID 508
D N++ P+FN S+Y ++ + PGT ++ V ATD+D G G V Y I G + F+ID
Sbjct: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 228
Query: 509 PYLGIIS 515
G+ S
Sbjct: 229 STTGLYS 235
Score = 47.4 bits (111), Expect = 3e-04
Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 19/198 (9%)
Query: 33 FTHSHYNATIYEN---SSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVV 89
F Y +YE+ SP V++ E + +EP + YRI SGD+ F +
Sbjct: 377 FERPKYTFLVYEDVPEDSPIGTVKAREPLNS--SEP---IFYRISSGDLGGKFSIHPRLG 431
Query: 90 GNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFS 149
IRT+ L+ E + L +QA + + T V + ++D ND P F
Sbjct: 432 ------TIRTRKP----LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481
Query: 150 PPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF-NTRSEMFAIHPTSGVVTVAGK 208
S + IS+ P + + A D D G+N Y+ + + +FAI GV+ + G
Sbjct: 482 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGS 541
Query: 209 LNVTWRGKHELQVLAVDR 226
L + + L + A D+
Sbjct: 542 LGAGEQRELTLTLRAEDQ 559
Score = 38.5 bits (88), Expect = 0.15
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
L A V V + D ND P+F+P +Y +IS++ + I V ATD D G Y
Sbjct: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 216
Query: 188 --NTRSEMFAIHPTSGV 202
S +F I T+G+
Sbjct: 217 IPGNVSSLFTIDSTTGL 233
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 407 bits (1045), Expect = e-112
Identities = 309/983 (31%), Positives = 466/983 (47%), Gaps = 44/983 (4%)
Query: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSL--VRGTTPESNKDGVFSLDPDT 2746
P+F P Y + PE+ P G+ + ++A+ + L +S + FSLDP T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2747 GVIKVRKPMDHE--STKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKA 2804
G + + +D E ST ++++ H + +L ++ I V D ND+ PVFE YK
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRS--ALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELD 2864
L EN+ VG V+ V A D D + + YRL G + E+F ID SG I T +D
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 2865 CETCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
E ++Y V A D G+ S+ A V +S+ D+NDNAP+F+ + Y V E+ PG
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D N V I G+ GQF + +Q G + LD E T +Y L
Sbjct: 417 PVLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTG---ALDVVSPLDYETTKEYTL 472
Query: 2983 RVTASDGK----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDL 3038
RV A DG S V + VLD+NDN+P + V E V G+ +L V A D
Sbjct: 473 RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 3039 DTDTNAQITYSLHGPGAHEFK--LDPHTGELTTLTALDRERKDVFNLVAKATDGG--GRS 3094
D NA++ Y L G G H+F ++ TG ++ LDRE D ++ +A D G +
Sbjct: 533 DAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
Query: 3095 CQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPD 3154
A +++ V DVNDN P F V + ++ V T V V A D D A++ + Y +
Sbjct: 592 ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITS 649
Query: 3155 -SAEGHFSIDATTG--VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGL 3211
+ FSI + +G ++ L PL + + L V ASD GT + V+V
Sbjct: 650 GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTR---QDTAQIVVNVTDA 705
Query: 3212 EDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ PVF ++ ++V V ED P GT V+ ++ E + +FR+DA TG
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG 765
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVL 3331
+ A LD+E Y L+I SD T + + + DVN++ PQF +D Y V
Sbjct: 766 AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 3332 ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGELQVAKALDREQAS 3390
E+ +L +SATD D LN + Y+ GG+ G F + G ++ + LDRE +
Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVA 885
Query: 3391 SYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLIL 3450
Y L+ A D G PP ++ + V DVNDNPP F Q + V+ENSPIG V ++
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
Query: 3451 SDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDSGIP 3509
+DPD N ++I +GN F++ G L L + Y L IQA+ +
Sbjct: 946 TDPDEGTNA-QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA--- 1001
Query: 3510 PLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVGKIHATDRDPQDTLT 3565
PL S +V V + +++ P EI ++T F GG +G++ A D D D+LT
Sbjct: 1002 PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLT 1061
Query: 3566 YSLAEEETLGRHFSVGAPDGKIIAAQGLPRG---HYSFNVTVSDGTFTTTAGVHVYVWHV 3622
YS L + A G++ ++ L +V VSDG + TA + V +
Sbjct: 1062 YSFERGNELSL-VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTII 1120
Query: 3623 GQEALQQAMWMGFYQLTPEELVS 3645
E L ++ + ++PE +S
Sbjct: 1121 TDEMLTHSITLRLEDMSPERFLS 1143
Score = 382 bits (982), Expect = e-105
Identities = 287/952 (30%), Positives = 448/952 (47%), Gaps = 86/952 (9%)
Query: 361 KFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN----LQYVLKP---SSENVGFKLNARTG 413
+F+ Y+ + E P G+ V +R L+Y + S N F L+ TG
Sbjct: 180 QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
Query: 414 LITTTKLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLD 468
+TT + +D ++ + + A + I + D N+H P+F + Y +L
Sbjct: 240 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
Query: 469 ENIPPGTSVLAVTATDRDHGENGYVTYSI----AGPKALPFSIDPYLGIISTSKPMDYEL 524
EN+ G VL V ATD D N + Y + G + F IDP G+I T P+D E
Sbjct: 300 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 525 MKRIYTFRVRASDWG-SPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSI 583
++ Y V ASD G P R ++FL + + NDN P F E +R+D G +
Sbjct: 360 VES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
Query: 584 MTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKIT 641
+ ++A D D+ N + Y I+SGN F L+ +G + + P T + Y+L++
Sbjct: 419 LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE---YTLRVR 475
Query: 642 ASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTS 701
A DG P + +G++T
Sbjct: 476 AQDGGR-------------------PPLSNVSGLVT------------------------ 492
Query: 702 LSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEG 761
+ IN P F P VLESVP+ + + A D DAG N +L Y +A +
Sbjct: 493 VQVLDINDNAPIFVS-TPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDF 551
Query: 762 CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFP 821
F I TG ++VAA LD E +FY V D GTP ++ ++V V D NDN P F
Sbjct: 552 PFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFT 611
Query: 822 PGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVT--G 879
Y + ++ED VGT++ ++ D D+ + T + +FS+ +G +V+
Sbjct: 612 QPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLAL 671
Query: 880 HLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP 939
LD + E +Y+L V A D + +++ + D N + P + H + V ED P
Sbjct: 672 PLDYKLERQYVLAVTASDGTRQ-----DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRP 726
Query: 940 PGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSL 999
GT + + A+D D G + Y M+ + FR+D TGA+ + ELD+E + Y L++
Sbjct: 727 AGTTVVLISATDEDTGENARITY-FMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAI 785
Query: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059
A D G P T ++E++V DVN+N P F +QG V E+ P T V+ ++A D
Sbjct: 786 TARDNGIPQKSDT-TYLEILVNDVNDN--APQFLRDSYQGSVYEDVPPFTSVLQISATDR 842
Query: 1060 DSGLDGELQYFLRAG-TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSGL+G + Y + G G F + +G+++TL LDRE + Y L AVD+G P
Sbjct: 843 DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
+ EV + V D NDNPP Q F ++E++P+G +V ++ A DPD + ++ + I
Sbjct: 903 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
GN F + +G L+ LD E++ E++L V+ L S + V V +LD NDN
Sbjct: 963 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVL---VIQATSAPLVSRATVHVRLLDRNDN 1019
Query: 1239 PPIFSH--KLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDE 1288
PP+ + LFN + R S G + R+ A D D ++ +TYS E +E
Sbjct: 1020 PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNE 1069
Score = 381 bits (979), Expect = e-105
Identities = 304/1044 (29%), Positives = 485/1044 (46%), Gaps = 89/1044 (8%)
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI----AGPKALPFSID 508
N AP F SY T+ EN P GT V ++ A D D GE G + Y++ FS+D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 509 PYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVN 568
P G ++T++ +D E K + FRV A D G P RR ++ + + + ND+ P+FE+
Sbjct: 236 PVTGAVTTAEELDRE-TKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQE 293
Query: 569 CTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHFSGVISLKR 623
S+R++ VG ++T+ A D D N+ Y ++ G+ E F+++ SGVI +
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 624 PFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTI 683
P + + SY L + ASD P + V
Sbjct: 354 P---VDREEVESYQLTVEASDQGRDPGPRSTTAAVF------------------------ 386
Query: 684 LHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPD 743
LS N PQF + + V E V P+ R+ A+D D
Sbjct: 387 ------------------LSVEDDNDNAPQFSEK-RYVVQVREDVTPGAPVLRVTASDRD 427
Query: 744 AGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSW 803
G N + Y I GN G F ++ +TG L V +PLDYE T Y L V D G P S+
Sbjct: 428 KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNV 487
Query: 804 K-LLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL--L 860
L+TV V D NDNAP F +Q T+ E +G + + DAD+ DN R+ Y L +
Sbjct: 488 SGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
Query: 861 SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVND 920
F+++ TG + V LDRE Y VEARD + L + + +T+ DVND
Sbjct: 548 GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA--LTASASVSVTVLDVND 605
Query: 921 NSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTG 979
N+P +++ ED GT + + A D D + Y + G F + +G
Sbjct: 606 NNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV--ITYQITSGNTRNRFSITSQSG 663
Query: 980 A--LILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVH 1037
+ L LD++ Y L++ ASDG R +++V + N H P F S +
Sbjct: 664 GGLVSLALPLDYKLERQYVLAVTASDGTRQDT------AQIVVNVTDANTHRPVFQSSHY 717
Query: 1038 QGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDR 1097
V E+ P+GT V++++A D+D+G + + YF+ + F I+ DTG + T A LD
Sbjct: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDADTGAVTTQAELDY 775
Query: 1098 EFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL 1157
E Y L + A D G S T + I V D NDN PQ + + S+ ED P TSVL
Sbjct: 776 EDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVL 835
Query: 1158 QLDAWDPDSSSKGKLTFNITSG-NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD 1216
Q+ A D DS G++ + G + G F++ +G++ T ++LDREN +++L +D
Sbjct: 836 QISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVD 895
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLN 1276
G P ++ V V +LDVNDNPP+F F+V + E SP+ V R+ A+D DEG N
Sbjct: 896 KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN-SPIGLA-VARVTATDPDEGTN 953
Query: 1277 GRVTYSI-EDSDEEAFSIDLVTGVVSS--SSTFTAGEYNILTIKATDSGQPPLSASVRLH 1333
++ Y I E + E F +D+ +G +++ + +L I+AT + PL + +H
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVH 1010
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGL---FWFNISGGDK 1389
+ + + F+ + ++ + +G + P + ++ G++
Sbjct: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD-PDISDSLTYSFERGNE 1069
Query: 1390 DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFL 1449
+ +TG + ++R LD R ++V V+DG ++ Q + + + +
Sbjct: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSI 1129
Query: 1450 ETRYEVRVPQDTVPGVELLRVQAI 1473
R E P+ + + L +QA+
Sbjct: 1130 TLRLEDMSPERFLSPLLGLFIQAV 1153
Score = 371 bits (953), Expect = e-102
Identities = 307/976 (31%), Positives = 468/976 (47%), Gaps = 55/976 (5%)
Query: 688 GLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFN 747
GL+ E S EE + + PQF+ Q+ V E+ P TP+A L A DPD G
Sbjct: 155 GLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQAT-VPENQPAGTPVASLRAIDPDEGEA 213
Query: 748 GKLVYV---IADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWK 804
G+L Y + D F ++ TG +T A LD E + ++ VT D G P++S+
Sbjct: 214 GRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALA 273
Query: 805 LLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL---- 860
LT+ V D ND+ P F Y+ ++ E+ EVG + + D D+ N + Y LL
Sbjct: 274 TLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG 333
Query: 861 -SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVN 919
SP+E F + P +G + G +DRE Y L VEA DQ + + +++ED N
Sbjct: 334 GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDN 393
Query: 920 DNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMT 978
DN+PQ + ++V ED+ PG + + ASD D G V Y +M G A G F +D T
Sbjct: 394 DNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT 453
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
GAL + LD+E Y L + A DGGRP V V VLD+N+N P F S Q
Sbjct: 454 GALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA--PIFVSTPFQ 511
Query: 1039 GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLA-AFSINQDTGMIQTLAPLDR 1097
V E+ P G V+ V A D D+G + L+Y L AG G F+IN TG I A LDR
Sbjct: 512 ATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-AGVGHDFPFTINNGTGWISVAAELDR 570
Query: 1098 EFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL 1157
E +Y V A D G+ L++ V + V D NDN P +Q + + EDA VGTSV+
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
Query: 1158 QLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT--GLLSTAQQLDRENKDEHILEVTVL 1215
+ A D D+ S +T+ ITSGN F I + GL+S A LD + + +++L VT
Sbjct: 631 TVSAVDRDAHS--VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGL 1275
D + + T+++VV + D N + P+F + V + E + V + A+D D G
Sbjct: 689 DG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNE--DRPAGTTVVLISATDEDTGE 743
Query: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEY--NILTIKATDSGQPPLSASVRLH 1333
N R+TY +EDS + F ID TG V++ + + L I A D+G P S + +
Sbjct: 744 NARITYFMEDSIPQ-FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTT--Y 800
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---GRPGLFWFNISGGDK- 1389
+E + + P ++Y + P ++ + + + G G ++ GGD
Sbjct: 801 LEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDG 860
Query: 1390 DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQ 1447
D DF +E T+G + R LD + Y L D G T + + + + ++N + P
Sbjct: 861 DGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV 920
Query: 1448 FLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGV 1505
F + ++V V +++ G+ + RV A D D+G + ++Y I P +FQLD SG
Sbjct: 921 FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIP---EVFQLDIFSGE 977
Query: 1506 LVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE--DGNLHPPRFTQL----- 1558
L + LD P ++ L + + + T+HV D N +PP
Sbjct: 978 LTALVDLDYEDRP-EYVLVIQATSAPLVSR-----ATVHVRLLDRNDNPPVLGNFEILFN 1031
Query: 1559 HYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKL 1618
+Y + + PG + +V A D D ++ + YS +GN +NA G + L++ L
Sbjct: 1032 NYVTNRSSSF-PGGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
Query: 1619 DQANHAPHTLTVKAED 1634
D ++V D
Sbjct: 1089 DNNRPLEAIMSVLVSD 1104
Score = 342 bits (877), Expect = 5e-93
Identities = 302/1001 (30%), Positives = 469/1001 (46%), Gaps = 54/1001 (5%)
Query: 2377 PEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDRHFFINSSS 2433
P+F+ P Y+A V E G V ++AIDPD + RLEY + ++ F ++ +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2434 GIISMFNLCKKHLDSSYNLRVGASD-GVFR--ATVPVYINTTNANKYSPEFQQHLYEAEL 2490
G ++ + S++ RV A D G+ R A + I T+ N + P F+Q Y+ L
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 2491 AENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLA---SEKFSINP-NGQIATLQKLDRE 2546
EN VG +V+ + A D D+ P I Y ++ SE F I+P +G I T +DRE
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
Query: 2547 N--STERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPV 2604
S + + RD G R V + + D+NDN PQF Y V ++ +V+ +PV
Sbjct: 359 EVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
Query: 2605 IQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQ 2664
++V A D D+G NA V YS+ + + ++ TG + V L + ++AQ
Sbjct: 419 LRVTASDRDKGSNAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
Query: 2665 DGG-PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI 2723
DGG PP N V +QV+ + P F + + E +P G + V+A+ A D
Sbjct: 478 DGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA-DAGD 536
Query: 2724 YSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSV 2783
+ + D F+++ TG I V +D E Y V A + + SV
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
Query: 2784 NIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSN 2843
++ V DVNDN P F Y L E+ VGTSV+ V+A+D+D ++Y++++ N
Sbjct: 597 SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITS---GN 651
Query: 2844 VHELFAIDSES--GWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDEND 2901
F+I S+S G ++ LD + + Y V A D + A + V++TD N
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT 707
Query: 2902 NAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG 2961
+ P F S Y +V E+ G V + D D E N ++T ++ + P QF I
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIP--QFRID--A 762
Query: 2962 DEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVT--VEIFVLDVNDNSPQCSQLLYTG 3018
D ++++ LD E Y L +TA D G Q S T +EI V DVNDN+PQ + Y G
Sbjct: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
Query: 3019 KVHEDVFPGHFILKVSATDLDTDTNAQITYSLHG--PGAHEFKLDPHTGELTTLTALDRE 3076
V+EDV P +L++SATD D+ N ++ Y+ G G +F ++ +G + TL LDRE
Sbjct: 823 SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
Query: 3077 RKDVFNLVAKATDGGGRSCQA--DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAV 3134
+ L A A D G + ++T+ V DVNDN P F V V +N+ + VA
Sbjct: 883 NVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR 942
Query: 3135 VFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRAS 3190
V A DPD+G NAQ++Y + EG+ F +D +G + L + L ++A
Sbjct: 943 VTATDPDEGTNAQIMYQI---VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA- 998
Query: 3191 DLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTE----HSVQVPEDAPPGTEVLQLATLTRP 3246
T PL + TV V ++ D PV N E + V + PG + ++
Sbjct: 999 ---TSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD 1055
Query: 3247 GAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTT 3306
++ Y GNE L+A TG L ++ +LD + +S+ S S +
Sbjct: 1056 ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCAL 1115
Query: 3307 VMVNITD-VNEHRPQFPQDPYSTRVLENALVGDVILTVSAT 3346
+ ITD + H + S + L+G I V+AT
Sbjct: 1116 RVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAAT 1156
Score = 321 bits (822), Expect = 1e-86
Identities = 275/966 (28%), Positives = 443/966 (45%), Gaps = 62/966 (6%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVF--------SMNS 1707
+AP F Y +PE+ P G+P+ + A+ P E E D +F S++
Sbjct: 177 TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVG 1765
+G ++T ++LD E S++ ++ + + + I+ D ND+ P+F + +
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEA---LKFFKIDPSMGTL 1822
+ E ++ + A+D D N+ ++Y++LE + F+IDP G +
Sbjct: 297 SLREN-------LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349
Query: 1823 TIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIV 1882
+D E + S+Q V DQG A V + V D ND+ P+FSE+ Y V +
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 1883 GPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK 1938
+ PG +L V ASD D + V+YSI +GNA + TG++ V++P +++
Sbjct: 410 EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
Query: 1939 LT--IRASDG----LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA 1992
T +RA DG L + LV + + + D + F + A V E++ ++ + A
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
Query: 1993 QGNHLNDT--LSYFLLN-GTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
D L Y L G D + + + DRE+ D + VE RD+ TP
Sbjct: 530 IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
Query: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
A V V++ DVNDN P F Y + + G + VSA D D + +TY+
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQI 647
Query: 2110 AEDYTY--FRIDPYLGD--ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRN 2165
T F I G +SL P DY+ +Y L V A DG T ++ V VT N
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG-TRQDTAQIVVNVTDAN 706
Query: 2166 KSNPLFQSPYYKVRVPENITLYTPIL---HTQARSPEGLRLIYNIVEEEPLMLFTTDFKT 2222
P+FQS +Y V V E+ T ++ T + E R+ Y + E+ + F D T
Sbjct: 707 THRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDADT 764
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSI 2281
G +T LDYE + + + A D + S+ T +E+LV DVNDN P F + Y S+
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E +P T V+Q+ A+D+DSG N V Y + G D F + ++G + T++ LD E
Sbjct: 825 YEDVPPFTSVLQISATDRDSGLNGRVFYTF-QGGDDGDGDFIVESTSGIVRTLRRLDREN 883
Query: 2342 QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV 2401
+ ++ A+DKG PP V V V D+NDNPP F Q +++ V E + G V +V
Sbjct: 884 VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Query: 2402 QAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG-- 2459
A DPD +++ Y I+ GN F ++ SG ++ Y L + A+
Sbjct: 944 TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPL 1003
Query: 2460 VFRATVPVYINTTNAN-----KYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYG 2514
V RATV V + N N + F ++ ++ G + + A D D
Sbjct: 1004 VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTN---RSSSFPGGAIGRVPAHDPDISDSL 1060
Query: 2515 TIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRV-AFCTVKI 2573
T + N+L+ + + G++ + LD E +++ V+ DG V A C +++
Sbjct: 1061 TYSFERGNELSLVLLNAS-TGELKLSRALDNNRPLEAIMS--VLVSDGVHSVTAQCALRV 1117
Query: 2574 -ILTDE 2578
I+TDE
Sbjct: 1118 TIITDE 1123
Score = 306 bits (784), Expect = 3e-82
Identities = 277/1016 (27%), Positives = 445/1016 (43%), Gaps = 140/1016 (13%)
Query: 146 PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA----FNTRS-EMFAIHPTS 200
P F PPSY+ T+ E+ P +P+ + A D D G+ Y F++RS + F++ P +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 201 GVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV 260
G VT A +L+ + H +V A D + + A+A++
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDH----------------------GMPRRSALATLT 276
Query: 261 VTPPDSND------GTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSL 314
+ D+ND Y L + G EV +V GD + + + S
Sbjct: 277 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
Query: 315 VSVKDIN------------WMEYLHGFNLSLQARS---GSGPYFYSQIRGFHLPPSKLSS 359
V +I+ E + + L+++A GP + + ++
Sbjct: 337 SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
Query: 360 LKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN----LQYVLKPSSENVGFKLNARTGLI 415
+F + Y VQ+ E PG+ V+ V + + Y + + F L+A+TG +
Sbjct: 397 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGAL 456
Query: 416 TTTKLMDFHDRAHYQLHIRTSPG------QASTVVVIDIVDCNNHAPLFNRSSYDGTLDE 469
+D+ Y L +R G S +V + ++D N++AP+F + + T+ E
Sbjct: 457 DVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE 516
Query: 470 NIPPGTSVLAVTATDRDHGENGYVTYSIAG-PKALPFSIDPYLGIISTSKPMDYELMKRI 528
++P G VL V A D D G+N + Y +AG PF+I+ G IS + +D E +
Sbjct: 517 SVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD-F 575
Query: 529 YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588
Y+F V A D G+P S+ + + ++NDN P F + T + +D VG S++T+SA
Sbjct: 576 YSFGVEARDHGTP-ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA 634
Query: 589 IDVDELQNLKYEIVSGNELEYFDLNHFS--GVISLKRPFINLTAGQPTSYSLKITASDGK 646
+D D + Y+I SGN F + S G++SL P L Y L +TASDG
Sbjct: 635 VDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALP---LDYKLERQYVLAVTASDGT 691
Query: 647 NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706
T + V D + PV +Q
Sbjct: 692 R--QDTAQIVVNVTDANTHRPV------------------------------------FQ 713
Query: 707 INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766
+HYT ++V E P T + ++ATD D G N ++ Y + D + F I+
Sbjct: 714 SSHYT----------VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRID 761
Query: 767 LETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQ 826
+TG +T A LDYE Y L +T D G PQKS L + V D NDNAP+F YQ
Sbjct: 762 ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
Query: 827 LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLDR 883
++ ED T++ +++ D DS NGRV YT + F + +G + LDR
Sbjct: 822 GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
Query: 884 ESEPRYILKVEARDQ---PSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940
E+ +Y+L+ A D+ P++ + ++ +T+ DVNDN P + + V E+ P
Sbjct: 882 ENVAQYVLRAYAVDKGMPPAR-----TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
Query: 941 GTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSL 999
G + + A+DPD G ++ Y +++G F++D+ +G L +LD+E R Y L +
Sbjct: 937 GLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVI 996
Query: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF--VHQGQVQENSPS--GTQVIVVA 1055
A+ PL R HV +LD N+N PP +F + V S S G + V
Sbjct: 997 QATSA--PLVSRATVHVR--LLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVP 1050
Query: 1056 AQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
A D D + L Y G L+ +N TG ++ LD ++VL D
Sbjct: 1051 AHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 287 bits (735), Expect = 1e-76
Identities = 224/679 (32%), Positives = 324/679 (47%), Gaps = 31/679 (4%)
Query: 2901 DNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV 2960
+ AP+F Y+ +V EN G VA+L+ +D D E R D S
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 2961 GDEWRISSRKTLDREHTAKYLLRVTASD---GKFQASVTVEIFVLDVNDNSPQCSQLLYT 3017
+++ + LDRE + ++ RVTA D + A T+ I V D ND+ P Q Y
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 3018 GKVHEDVFPGHFILKVSATDLDTDTNAQITYSL----HGPGAHEFKLDPHTGELTTLTAL 3073
+ E++ G+ +L V ATD D NA I Y L G + F++DP +G + T +
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 3074 DRERKDVFNLVAKAT----DGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVK 3129
DRE + + L +A+ D G RS A + L VED NDNAP+F V V ++ T
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 3130 TPVAVVFARDPDQGANAQVVYS-LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
PV V A D D+G+NA V YS + +A G F +DA TG + + PL L VR
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
Query: 3189 ASDLGTPIPLSTL-GTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPG 3247
A D G P PLS + G VTV V+ + D P+F++T V E P G VL + +
Sbjct: 476 AQDGGRP-PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 3248 AE--KTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVT 3305
+ + YR+ F ++ TG + V A LD E Y +E + +L+
Sbjct: 535 GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 3306 TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ 3365
+V V + DVN++ P F Q Y+ R+ E+A VG ++TVSA D D +S ITY + GN
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNT 652
Query: 3366 LGHFTIHPKKGE--LQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423
F+I + G + +A LD + Y L + A+D + + I + V D N +
Sbjct: 653 RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANTHR 709
Query: 3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGS--AFRVTPDG 3481
P F +Y+ V E+ P G+ V+ + +D D+ EN RIT S FR+ D
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA-----RITYFMEDSIPQFRIDADT 764
Query: 3482 WLVTAEG-LSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITV 3540
VT + L Q Y L I A D+GIP S T + + V + + AP L +V
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
Query: 3541 GEDEFQGGMVGKIHATDRD 3559
ED V +I ATDRD
Sbjct: 825 YEDVPPFTSVLQISATDRD 843
Score = 260 bits (665), Expect = 2e-68
Identities = 247/985 (25%), Positives = 432/985 (43%), Gaps = 65/985 (6%)
Query: 1324 PPLSASVRLHIEWIPWPRPSSIPLA--FDETYYSFTVMETDPVNHMVGVISV----EGRP 1377
P L A R E + R ++ A F Y TV E P V + EG
Sbjct: 154 PGLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEA 213
Query: 1378 GLFWFNISG---GDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS--RTIATQ 1432
G + + + F ++ TG++ A LD +S + V D R A
Sbjct: 214 GRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALA 273
Query: 1433 VHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDK--GKSLIYTIHGSQD 1490
++ + N H P F + Y+ + ++ G E+L V+A D D +++Y +
Sbjct: 274 TLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG 333
Query: 1491 PGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ--EIPIKRNFVWVTIHVEDG 1548
+ +F++DP SGV+ T G +D S + LTV DQ + + V + VED
Sbjct: 334 GSPSEVFEIDPRSGVIRTRGPVDREEVES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDD 392
Query: 1549 NLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINAL 1608
N + P+F++ Y V + + PG +L+V A D D+G NA VHYS++ GN+ G F ++A
Sbjct: 393 NDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQ 452
Query: 1609 LGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLA-TVIIHVYPSDRSAPIFSKSEYFV 1667
G + + LD +TL V+A+D G P +++ V + V + +APIF + +
Sbjct: 453 TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
Query: 1668 EIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEK 1722
+ ES+P+G +L V A+ + + Y L D F++N+ +G IS +LD E+
Sbjct: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREE 572
Query: 1723 IS--SYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDK 1780
+ S+ ++ R V V ++D NDN P F + + +++E A +
Sbjct: 573 VDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV------- 625
Query: 1781 NNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQF 1838
V+ S D++A+S++ Y+I F I G +++ +DY+ +
Sbjct: 626 --GTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVL 683
Query: 1839 CVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASD 1898
V D AQ++++V D N P F Y V + G ++++ A+D
Sbjct: 684 AVTASDG-----TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 1899 EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG----LSRKLTIRASD-GLYQ--DT 1951
ED+ N I D + +V A L +S L I A D G+ Q DT
Sbjct: 739 EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
Query: 1952 ALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNGT 2009
++I + V D + QF +D Y +V E++ +++ + A + + LN + Y G
Sbjct: 799 TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD 858
Query: 2010 D---MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDN 2066
D F + ++G+++T DRE + L D P V V++ DVNDN
Sbjct: 859 DGDGDFIVESTSGIVRTLR-RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
Query: 2067 PPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY--TYFRIDPYLGD 2124
PP F+ + +++ + G + +V+ATD D GTN + Y+ E F++D + G+
Sbjct: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
Query: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENI 2184
++ DY+ +Y L + A S ++ V + RN + P+ + +++ +
Sbjct: 978 LTALVDLDYEDRPEYVLVIQATSAPLVS-RATVHVRLLDRNDNPPVLGN--FEILFNNYV 1034
Query: 2185 TLYT------PILHTQARSPE-GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKT 2237
T + I A P+ L Y+ L L + TG L ++ LD
Sbjct: 1035 TNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPL 1094
Query: 2238 KHVFTVRATDTALGSFSEATVEVLV 2262
+ + +V +D ++ + V +
Sbjct: 1095 EAIMSVLVSDGVHSVTAQCALRVTI 1119
Score = 249 bits (636), Expect = 4e-65
Identities = 189/599 (31%), Positives = 280/599 (46%), Gaps = 24/599 (4%)
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHG----PGAHEFKLD 3061
+ +PQ Y V E+ G + + A D D ++ Y++ F LD
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 3062 PHTGELTTLTALDRERKD--VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCA 3119
P TG +TT LDRE K VF + A+ RS A +T+ V D ND+ P F
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 3120 VAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPL 3175
++ +N V V V A D D NA ++Y L + + G F ID +GVIR P+
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 3176 QVRPQAPLELTVRASDLGT-PIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPG 3234
+LTV ASD G P P ST V +SV D P F + VQV ED PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 3235 TEVLQLATLTRPGAEKT--GYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
VL++ R Y ++SGN +G+F LDA+TG L V + LD+ET+ +Y L +
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
Query: 3293 CSRKSSSSLSDVT-TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGP 3351
LS+V+ V V + D+N++ P F P+ VLE+ +G ++L V A D D
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTD 3411
N+ + Y L G FTI+ G + VA LDRE+ YS + A D G P L
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS 595
Query: 3412 IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNN 3471
+++ V DVNDN P F Q Y+ + E++ +G+ V+ + D D+ +++IT GN
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS---VITYQITSGNT 652
Query: 3472 GSAFRVTPD---GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYA 3528
+ F +T G + A L + + Y L + ASD + V+VT+ + +
Sbjct: 653 RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHR 709
Query: 3529 PSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKI 3587
P + V ED G V I ATD D + + E+++ + F + A G +
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FRIDADTGAV 767
Score = 231 bits (590), Expect = 9e-60
Identities = 239/954 (25%), Positives = 399/954 (41%), Gaps = 121/954 (12%)
Query: 107 LNREVRDSYTLIIQATEKTL-ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE + ++ + A + + AL + + + D ND P+F Y+ ++ E++ +
Sbjct: 247 LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ V ATD D NA Y + SE+F I P SGV+ G ++ ++L
Sbjct: 307 EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIAS---VVVTPPDSNDGTTYATVLV 277
V A D+ R + + AA+ + VE P + VV D G V
Sbjct: 367 VEASDQGR---DPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
Query: 278 DANSSGAE-VESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQAR 336
G+ V ++ G+ F A++ +VS D E + L ++A+
Sbjct: 424 SDRDKGSNAVVHYSIMSGNARGQFYL---DAQTGALDVVSPLD---YETTKEYTLRVRAQ 477
Query: 337 SGSGPYFYSQIRGF---HLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA---- 389
G P S + G + ++ F ++ + E P G V+ V+ A
Sbjct: 478 DGGRPPL-SNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
Query: 390 FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQASTVV 444
L+Y L + F +N TG I+ +D + Y + T AS V
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKAL 503
+ ++D N++ P F + Y L+E+ GTSV+ V+A DRD + +TY I +G
Sbjct: 597 SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRN 654
Query: 504 PFSIDPYL--GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
FSI G++S + P+DY+L +R Y V ASD R+ I + + + N ++
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKL-ERQYVLAVTASDG----TRQDTAQIVVNVTDANTHR 709
Query: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISL 621
P+F+ + T ++ +D P G +++ +SA D D +N + + + F ++ +G ++
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTT 769
Query: 622 KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681
+ L SY+L ITA D G+
Sbjct: 770 Q---AELDYEDQVSYTLAITARD----------------------------NGI------ 792
Query: 682 TILHFIGLQNQESSDEEFTSLSTYQINHYTPQF-EDHFPQSIDVLESVPINTPLARLAAT 740
+ SD + + +N PQF D + S V E VP T + +++AT
Sbjct: 793 ----------PQKSDTTYLEILVNDVNDNAPQFLRDSYQGS--VYEDVPPFTSVLQISAT 840
Query: 741 DPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQ 799
D D+G NG++ Y G++ +G F +E +G++ LD E Y+L D G P
Sbjct: 841 DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP 900
Query: 800 KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL 859
+ +TV V D NDN P F + + + E++ +G +A +T D D N ++ Y +
Sbjct: 901 ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960
Query: 860 LSPT--EKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLED 917
+ E F L +GEL LD E P Y+L ++A P L S + + L D
Sbjct: 961 VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAP-----LVSRATVHVRLLD 1015
Query: 918 VNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA--------GEVRYVLM 965
NDN P I +N + PG + + A DPD+ + E+ VL+
Sbjct: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLL 1075
Query: 966 DGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVI 1019
+ + TG L L R LD R +S+ SDG + + V +I
Sbjct: 1076 NAS---------TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTII 1120
Score = 160 bits (406), Expect = 2e-38
Identities = 197/754 (26%), Positives = 309/754 (40%), Gaps = 111/754 (14%)
Query: 69 VRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTAL-LNREVRDSYTLIIQATE--KT 125
V Y I+SG+ F +L +T + + L+ E YTL ++A + +
Sbjct: 434 VHYSIMSGNARGQF-----------YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
Query: 126 LELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNA--EF 183
V V +LD ND P+F ++ T+ E +PL + V A DAD G NA E+
Sbjct: 483 PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
Query: 184 YYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALV 243
A F I+ +G ++VA +L+ R+ + FG A
Sbjct: 543 RLAGVGHDFPFTINNGTGWISVAAELD-----------------REEVDFYSFGVEAR-- 583
Query: 244 VHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGG-DPGKH--- 299
H PAL +++ V+ D+N T V N A SV V D H
Sbjct: 584 DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVI 643
Query: 300 FKAIKSYARSNEFSLVS------VKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP 353
I S N FS+ S V ++Y L + G + ++
Sbjct: 644 TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVT 703
Query: 354 PSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLN 409
+ F+ + Y V ++E P G+ VV++ T + Y ++ S F+++
Sbjct: 704 DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRID 761
Query: 410 ARTGLITTTKLMDFHDRAHYQLHIRTSPG---QASTVVVIDIV--DCNNHAPLFNRSSYD 464
A TG +TT +D+ D+ Y L I Q S ++I+ D N++AP F R SY
Sbjct: 762 ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
Query: 465 GTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDY 522
G++ E++PP TSVL ++ATDRD G NG V Y+ G F ++ GI+ T + +D
Sbjct: 822 GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
Query: 523 ELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKS 582
E + + Y R A D G P R + + + + ++NDN P+FE+ + ++ P+G +
Sbjct: 882 ENVAQ-YVLRAYAVDKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
Query: 583 IMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKI 640
+ ++A D DE N + Y+IV GN E F L+ FSG ++ ++L Y L I
Sbjct: 940 VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVDLDYEDRPEYVLVI 996
Query: 641 TASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFT 700
A+ ++P TV H + D VL F
Sbjct: 997 QAT-----SAPLVSRATV----HVRLLDRNDNPPVLGNF--------------------- 1026
Query: 701 SLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEE 760
N+Y FP + R+ A DPD + L Y GNE
Sbjct: 1027 ---EILFNNYVTNRSSSFP-----------GGAIGRVPAHDPD--ISDSLTYSFERGNEL 1070
Query: 761 GCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
+ TG L ++ LD I++V V D
Sbjct: 1071 SLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 121 bits (304), Expect = 1e-26
Identities = 151/626 (24%), Positives = 262/626 (41%), Gaps = 71/626 (11%)
Query: 102 SNTALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160
S A L+RE D Y+ ++A + T L A V V +LD ND P F+ P Y V ++ED
Sbjct: 563 SVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED 622
Query: 161 MPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTS--GVVTVAGKLNVTWRGKHE 218
+ + + V+A D D + F+I S G+V++A L+ ++
Sbjct: 623 AAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYV 682
Query: 219 LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278
L V A D R+ A +VV+V A P S T + D TV++
Sbjct: 683 LAVTASDGTRQ--------DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLI 734
Query: 279 ANSSGAEVESVEVVGGDPGKHF--KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQAR 336
+ + E+ + +F +I + + V+ + E + L++ AR
Sbjct: 735 SATDEDTGENARIT------YFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITAR 788
Query: 337 SGSGPY----FYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN 392
P Y +I + ++ +F + Y+ + E PP + V+ + T
Sbjct: 789 DNGIPQKSDTTYLEIL---VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSG 845
Query: 393 LQ----YVLKPSSENVG-FKLNARTGLITTTKLMDFHDRAHYQLHIRT-----SPGQAST 442
L Y + + G F + + +G++ T + +D + A Y L P +
Sbjct: 846 LNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPM 905
Query: 443 VVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA-GPK 501
V + ++D N++ P+F + +D ++EN P G +V VTATD D G N + Y I G
Sbjct: 906 EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI 965
Query: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
F +D + G ++ +DYE + Y ++A+ +P ++ ++L + NDN
Sbjct: 966 PEVFQLDIFSGELTALVDLDYE-DRPEYVLVIQAT--SAPL--VSRATVHVRLLDRNDNP 1020
Query: 562 PM---FEEV--NCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFS 616
P+ FE + N + +P G +I + A D D +L Y GNEL LN +
Sbjct: 1021 PVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAST 1079
Query: 617 GVISLKRPFINLTAGQPTSYSLKITASDG-KNYASPTTLNITVVKDPHFEVPVTCDKTGV 675
G + L R N +P + + SDG + + L +T++ D
Sbjct: 1080 GELKLSRALDN---NRPLEAIMSVLVSDGVHSVTAQCALRVTIITD-------------- 1122
Query: 676 LTQFTKTILHFIGLQNQESSDEEFTS 701
+ + H I L+ ++ S E F S
Sbjct: 1123 -----EMLTHSITLRLEDMSPERFLS 1143
Score = 72.4 bits (176), Expect = 9e-12
Identities = 110/493 (22%), Positives = 202/493 (40%), Gaps = 68/493 (13%)
Query: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92
FT Y + E+++ T V + + + + Y+I SG+ N F G
Sbjct: 610 FTQPEYTVRLNEDAAVGTSVVTVSAVD---RDAHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 93 CFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPS 152
L + L+ ++ Y L + A++ T + A ++VV++ D N +P+F
Sbjct: 667 VSLALP--------LDYKLERQYVLAVTASDGTRQDTA--QIVVNVTDANTHRPVFQSSH 716
Query: 153 YRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVT 212
Y V ++ED P + + ++ATD D G+NA Y F I +G VT +L+
Sbjct: 717 YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE 776
Query: 213 WRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE---PALRKPPAIASVVVTPPDSNDG 269
+ + L + A D I + + L LV V P + SV P
Sbjct: 777 DQVSYTLAITARD--NGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
Query: 270 TTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGF 329
+ D+ +G + + GGD G ++S + V+ + ++ +
Sbjct: 835 LQISATDRDSGLNGRVFYTFQ--GGDDGDGDFIVESTSG-------IVRTLRRLDRENVA 885
Query: 330 NLSLQARSGSGPYFYSQIRGFHLPPSKL-------------SSLKFEKAVYRVQLSEFSP 376
L+A Y+ +G +PP++ + FE+ + V + E SP
Sbjct: 886 QYVLRA--------YAVDKG--MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
Query: 377 PGSRVVMVRVTPAFP----NLQYVLKPSSENVG--FKLNARTGLITTTKLMDFHDRAHYQ 430
G + + RVT P N Q + + N+ F+L+ +G +T +D+ DR Y
Sbjct: 936 IG--LAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYV 993
Query: 431 LHIR--TSPGQASTVVVIDIVDCNNHAPLFNR-----SSYDGTLDENIPPGTSVLAVTAT 483
L I+ ++P + V + ++D N++ P+ ++Y + PG ++ V A
Sbjct: 994 LVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSF-PGGAIGRVPAH 1052
Query: 484 DRDHGENGYVTYS 496
D D ++ +TYS
Sbjct: 1053 DPDISDS--LTYS 1063
Score = 68.9 bits (167), Expect = 1e-10
Identities = 80/328 (24%), Positives = 119/328 (36%), Gaps = 55/328 (16%)
Query: 3722 MPMVPCQGPTCQGQICHNTVHLDPKVGPTYSTA--RLSILTPRHHLQRSCSCN-GTATRF 3778
+P P + C CHN G T S P +SC+ F
Sbjct: 1568 VPGCPAKKNVCDSNTCHN--------GGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHF 1619
Query: 3779 SGQSYVRYRA---PAARNWHIHFYLKTLQPQAILL--FTNETASVSLKLASGVPQLEYHC 3833
G S V + P ++ W++ +T Q +LL T ++++L+L G L
Sbjct: 1620 LGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEG 1679
Query: 3834 LGGFYGNLSSQR-HVNDHEWHSILVEEMDASIRLMVDSMGNTSLVV------PENCRG-L 3885
G +L + ND +WH +L + + G + + G L
Sbjct: 1680 TGLQASSLRLEPGRANDGDWHHA---------QLALGASGGPGHAILSFDYGQQRAEGNL 1730
Query: 3886 RPERH------LLLGGLILLHSSSNVSQGFEGCLDAVVVNE--EALDLLAPGKTVAGLLE 3937
P H + +GG+ + V++GF GCL V V++ E ++ L P E
Sbjct: 1731 GPRLHGLHLSNITVGGIP--GPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHG-----E 1783
Query: 3938 TQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLE 3997
+ + Q C D C N C CS Y C C P + G +C C PC
Sbjct: 1784 SINVEQGCSLPDPCDSNPCPANSYCS-NDWDSYSCSCDPGYYGDNCTNV---CDLNPCEH 1839
Query: 3998 GGTCILSPK---GASCNCPHPYTGDRCE 4022
C P G +C CP Y G CE
Sbjct: 1840 QSVCTRKPSAPHGYTCECPPNYLGPYCE 1867
Score = 58.5 bits (140), Expect = 1e-07
Identities = 27/67 (40%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Query: 3969 GYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG- 4027
G C+CPP F+G +CE + C PC G C G +C C YTG+ CE+ AR
Sbjct: 1271 GLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSG 1330
Query: 4028 -CSEGHC 4033
C+ G C
Sbjct: 1331 RCTPGVC 1337
Score = 57.4 bits (137), Expect = 3e-07
Identities = 44/144 (30%), Positives = 62/144 (43%), Gaps = 13/144 (9%)
Query: 3944 CCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGREN--CTFAPCLEGGTC 4001
C D C C G+C G GY C C ++G+HCE + CT C GGTC
Sbjct: 1285 CETEVDLCYSRPCGPHGRCRSREG-GYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTC 1343
Query: 4002 I-LSPKGASCNCPH-PYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFI 4059
+ L G C+CP + C++ R H +T G ++ T+A++F
Sbjct: 1344 VNLLVGGFKCDCPSGDFEKPYCQVTTRS-FPAHSFITFR------GLRQRFHFTLALSFA 1396
Query: 4060 IISTVGLLFYCRRC-KSHKPVAME 4082
GLL Y R + H VA+E
Sbjct: 1397 TKERDGLLLYNGRFNEKHDFVALE 1420
Score = 53.1 bits (126), Expect = 6e-06
Identities = 58/214 (27%), Positives = 86/214 (40%), Gaps = 31/214 (14%)
Query: 3795 HIHFYLKTLQPQAILLFT--NETASVSLKLASGVPQLEYHCLGGFY------GNLSSQRH 3846
H L+ +Q Q L F+ T +VS + GV ++H + Y G +
Sbjct: 1414 HDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQG 1473
Query: 3847 VNDHEWHSILVEEMDASIRLMVDS-MGNTSLVVPENCRGLRPERHL----LLGGLILLHS 3901
++ + + V+ D + L S +GN S G + L LLGG+ L
Sbjct: 1474 PSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPE 1533
Query: 3902 SSNVS-QGFEGCLDAVVVNEEALDL---LAPGKTVAGLLETQALTQCCLHSDYCSQNTCL 3957
S V + F GC+ + V+ +D+ +A TV G C + C NTC
Sbjct: 1534 SFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPG---------CPAKKNVCDSNTCH 1584
Query: 3958 NGGKC--SWTHGAGYVCKCPPQFSGKHCEQGREN 3989
NGG C W + C+CP F GK C Q N
Sbjct: 1585 NGGTCVNQWD---AFSCECPLGFGGKSCAQEMAN 1615
Score = 52.8 bits (125), Expect = 8e-06
Identities = 51/201 (25%), Positives = 81/201 (40%), Gaps = 13/201 (6%)
Query: 26 LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85
++ +A F Y ++YE+ P T V R ++G V F+
Sbjct: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD----------RDSGLNGRVFYTFQGG 857
Query: 86 EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDL 144
+ G+F L+RE Y L A +K + V V +LD ND
Sbjct: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN 917
Query: 145 KPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF--NTRSEMFAIHPTSGV 202
P+F + V + E+ P+ + +VTATD D G NA+ Y E+F + SG
Sbjct: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE 977
Query: 203 VTVAGKLNVTWRGKHELQVLA 223
+T L+ R ++ L + A
Sbjct: 978 LTALVDLDYEDRPEYVLVIQA 998
Score = 43.5 bits (101), Expect = 0.005
Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 56/294 (19%)
Query: 39 NATIYENSSPKTYVESFEKMGIYLAE---------PQWAVRYRIISGDVANVFKTEEYVV 89
N ++E +VE +G+ +A + Y+I+ G++ VF+ + +
Sbjct: 917 NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIF-- 974
Query: 90 GNFCFLRIRTKSSNTAL--LNREVRDSYTLIIQATEKTLELEALTRVVVHI--LDQNDLK 145
TAL L+ E R Y L+IQAT L ++R VH+ LD+ND
Sbjct: 975 ----------SGELTALVDLDYEDRPEYVLVIQATSAPL----VSRATVHVRLLDRNDNP 1020
Query: 146 PLFSP-----PSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTS 200
P+ +Y S P I +V A D D+ + + + + ++ ++
Sbjct: 1021 PVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAST 1079
Query: 201 GVVTVAGKLN-----------VTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPA 249
G + ++ L+ + G H + R+ I++ S+ + + P
Sbjct: 1080 GELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPE 1139
Query: 250 LRKPP-------AIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDP 296
P A+A+ + TPPD V D ++ G + +V + G P
Sbjct: 1140 RFLSPLLGLFIQAVAATLATPPDH---VVVFNVQRDTDAPGGHILNVSLSVGQP 1190
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 394 bits (1013), Expect = e-109
Identities = 367/1253 (29%), Positives = 547/1253 (43%), Gaps = 139/1253 (11%)
Query: 2010 DMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPK 2069
D FH+ G+++T DRE++D + Q V + + DVND+ P+
Sbjct: 114 DDFHVHPDTGIIRTAR-RLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPR 166
Query: 2070 FKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY--------TYFRI--- 2118
F + + + PG A D D G Y + +F++
Sbjct: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
Query: 2119 ------DPYL-GDISLKKPFDYQALNK--------YHLKVIARDGGTPSLQS--EEEVLV 2161
P L G S +P D L + + L++ A DGG P E+ V
Sbjct: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
Query: 2162 TVRNKSNPLFQSPYYKVRVPENITLYTPILHTQAR----SPEGLRLIYNIVEEE------ 2211
N + P+F+ Y+ V E+ + +A P G + Y++ +
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF-VRYSVRARQVPGAGS 345
Query: 2212 ------PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATD-TALGSFSEATVEVLVED 2264
F + +GV+ V PLD E++ H V A D A + V + V D
Sbjct: 346 GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
Query: 2265 VNDNPPTFSQLVYT----TSISEGLPAQTPVIQLLASDQDSG--RNRDVSYQIVEDGSDV 2318
VNDN P L T +SEG V ++ SD D + + + ++ D
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
Query: 2319 SKFFQINGSTGEMSTVQ-------------ELDYEAQQHFHVKVRAMDKGDPPLTGETLV 2365
S + G G+ + + LD E++ + + + A D G PPL+ E +
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 2366 VVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPD--SRDTSRLEYLI----- 2418
++ V+D+ND PP F Q Y+A+VSE A G +V+ V A D D D + L Y +
Sbjct: 526 LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
Query: 2419 ---LSGNQDR---------HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD---GVFRA 2463
L Q + F I+S SG IS + + + L+V A D A
Sbjct: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
Query: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI--- 2520
T V I + N P F + +Y A +AE+A VG + + A D DSG YG I+Y++
Sbjct: 646 TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
Query: 2521 -INKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDE 2578
++ A + F I+P +GQI Q +DRE + V A+DGGG A V++ L D
Sbjct: 706 FLSYEAPQAFRIDPHDGQICVSQDIDRERD-PATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
Query: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINP 2638
NDN P F S Y SI + +I VLA D D G V Y + P + V + I+
Sbjct: 765 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN-VSSLFTIDS 823
Query: 2639 VTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTF 2698
TG++ + L LE+ TL + AQDGG V + + ++ +F P YTF
Sbjct: 824 TTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
Query: 2699 SAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPM 2755
ED+PE S IG VKA + + +P+ Y + G + G FS+ P G I+ RKP+
Sbjct: 884 LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSG-----DLGGKFSIHPRLGTIRTRKPL 938
Query: 2756 DHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTS 2815
DHE+ + + V A L + S VNI V DVNDN P F + +++ P GT+
Sbjct: 939 DHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
Query: 2816 VIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
+ A D+D+GR+G + Y + S PG +FAID G + L +
Sbjct: 998 LYLARAEDRDSGRNGLIRYSIASPQPG-----VFAIDRALGVLFLNGSLGAGEQRELTLT 1052
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEE--YRGSVVENSEPGELVATLKTLD 2932
+ A D G + + LV + ++ +++P + E Y+ V E+ P + L+T
Sbjct: 1053 LRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQTQA 1108
Query: 2933 ADISEQN--RQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTA---S 2987
+ Q + + FGI W I R+ D E T Y RV A
Sbjct: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPY-TGW-IYLRRQFDYESTQTYNFRVFAWIPE 1166
Query: 2988 DGKFQ-ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQI 3046
DG Q S TV + V D NDNSP + KV E P I K++A D+D+ N Q+
Sbjct: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
Query: 3047 TYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGG--RSCQADITLHVE 3104
Y L G FK++P+TGEL ALDRE + + TD G R+ + + V
Sbjct: 1227 LYFLLSDGKF-FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 1285
Query: 3105 DVNDNAPRFFP-----SHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL 3152
D+NDN P FFP V V + V V VFA+DPD+G NA+V YS+
Sbjct: 1286 DINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 340 bits (872), Expect = 2e-92
Identities = 370/1319 (28%), Positives = 564/1319 (42%), Gaps = 173/1319 (13%)
Query: 718 FPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC----FDIELETGLLT 773
F ++ V E +P +T + + A P A + +++ +++ F + +TG++
Sbjct: 67 FNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIR 126
Query: 774 VAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDT 833
A LD E + Y V LG + + + V D ND++PRFP QL +SE +
Sbjct: 127 TARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVNDVNDHSPRFPLDSLQLDVSELS 180
Query: 834 EVGTTIAELTTKDADSEDNGRVRYTLLSPTE----------------------------K 865
GT D D+ YTL+ P++
Sbjct: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
Query: 866 FSLHPLTGELVVTGHLDRESEPRYILKVEARD--QPSKGHQLFSVTDLIITLEDVNDNSP 923
L PL +LV+ LDRE + L++EA D +P + + + + + D NDN P
Sbjct: 241 SPLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRR----TGLLSVELRVLDENDNPP 294
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY---------------VLMDGA 968
+ R V ED PG + + A+D DLGP G VRY L D A
Sbjct: 295 VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
Query: 969 HGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLH 1028
+ F V+ ++G + + R LD E +A + L + A DGG T+ V + VLDVN+N
Sbjct: 355 Y--FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDN-R 410
Query: 1029 PPHFASFVHQG---QVQENSPSGTQVIVVAAQDDDS--------------GL-DGELQYF 1070
P F+ +G +V E + G V V+ D D GL DG +
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
Query: 1071 LRAGTGLAAFSINQDTGM--IQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVT 1128
L G G A G+ + PLDRE Y L ++A D GS PLS+ + + V
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
Query: 1129 DANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK------------------G 1170
D ND PP SQ + S+ E A GT V+ + A D D + G
Sbjct: 531 DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
Query: 1171 KLTFNITSGNYMG-FFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229
L + G F I +G +ST + LDRE ++ L+V D GEP L +T V
Sbjct: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
Query: 1230 VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIED---- 1285
+ + DVNDN PIF +++N + E +PV ++ ASD D GL G + YS+ D
Sbjct: 651 ITVDDVNDNEPIFWRQVYNATIAEH-APVG-HCFLQVTASDADSGLYGFIEYSLYDGFLS 708
Query: 1286 -SDEEAFSIDLVTGVVSSSSTF----TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWP 1340
+AF ID G + S Y++L ++A D G A VR+ +E +
Sbjct: 709 YEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAKDGGGLSAQAFVRVDLEDVNDN 767
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFW---FNISGGDKDMDFDIEK 1397
P P TY + ET P ++ V++ + G++ + + G+ F I+
Sbjct: 768 HPVFNP----STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 823
Query: 1398 TTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIA-----TQVHIFM--IANINHHRPQFLE 1450
TTG I + PL + +L V DG A +HIF +A RP++
Sbjct: 824 TTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
Query: 1451 TRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVG 1510
YE VP+D+ G V+A + I+ S D G F + P G + T
Sbjct: 884 LVYE-DVPEDSPIGT----VKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRK 936
Query: 1511 KLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAP 1570
LD + P LTV + P + V I V D N + P F + E + T P
Sbjct: 937 PLDHETQPVV-VLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
Query: 1571 GTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTV 1630
GT L RA D D G N + YS + G F I+ LG++ L L TLT+
Sbjct: 995 GTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
Query: 1631 KAEDQG-SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA----- 1684
+AEDQG PQ L ++ + F Y VE+ ES+ + +L A
Sbjct: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
Query: 1685 -MSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAF---T 1740
+ S + Y L +F + Y+G I +++ D+E +Y ++ F
Sbjct: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
Query: 1741 DVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLL 1800
V+V + DENDN+P FL ++ E +P+ ++ K I A D D N L
Sbjct: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGK------ITAIDMDSGKNGQL 1226
Query: 1801 VYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPA--QV 1858
+Y +L KFFK++P+ G L +D E + V V D+GSP PR A V
Sbjct: 1227 LYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSP----PRNATMAV 1280
Query: 1859 IIHVRDVNDSPPRF-----SEQIYEVAIVG-PIHPGMELLMVRASDE--DSEVNYSIKT 1909
+ V D+ND+ P F ++++ + G P++ + + + DE ++EV YS+ +
Sbjct: 1281 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 325 bits (834), Expect = 5e-88
Identities = 352/1297 (27%), Positives = 543/1297 (41%), Gaps = 183/1297 (14%)
Query: 406 FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDG 465
F ++ TG+I T + +D R HY T G A V I + D N+H+P F S
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG-AVVQVEIRVNDVNDHSPRFPLDSLQL 174
Query: 466 TLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-------FSI---------DP 509
+ E PPGT+ A D D G Y++ P LP F + P
Sbjct: 175 DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
Query: 510 YL-GIISTSKPMDYELMKRI-------YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
L G S +P+D L++R+ + ++ A D G P RR +S+ L++ + NDN
Sbjct: 235 LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNP 293
Query: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEI----VSG--------NEL 607
P+FE+ ++R+D G + + A D D N ++Y + V G +
Sbjct: 294 PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
Query: 608 EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVP 667
YF + SGV+ + RP L + L + A DG A P + V
Sbjct: 354 AYFAVEELSGVVRVWRP---LDREAQAWHQLVVEARDGG--AEPEVATVRV--------- 399
Query: 668 VTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQS---IDV 724
S++ +N P F V
Sbjct: 400 ---------------------------------SIAVLDVNDNRPAIHVLFLTEGGVARV 426
Query: 725 LESVPINTPLARLAATDPDAGF------NGKLVYVIADGN-----EEGCFDIELETG--- 770
E +AR++ +D D + G+L + DG+ E G D L G
Sbjct: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
Query: 771 ---LLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQL 827
L V PLD E+ + Y L + D G+P S+ + L + V D ND P F Y+
Sbjct: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
Query: 828 TISEDTEVGTTIAELTTKDAD--SEDNGRVRYTLLSPTEKFSLHPLTGELVVTGH----- 880
++SE GT + ++ DAD D+ +RYT++ + +L L ++V T
Sbjct: 547 SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
Query: 881 --------------LDRESEPRYILKVEARDQPSKGHQLFSVTDLI-ITLEDVNDNSPQC 925
LDRE + LKV A+D G S T L+ IT++DVNDN P
Sbjct: 607 AIDSESGAISTIRTLDREVQEAVELKVVAQD---LGEPPLSATCLVSITVDDVNDNEPIF 663
Query: 926 ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-----AHGTFRVDLMTGA 980
+ + E P G + ASD D G G + Y L DG A FR+D G
Sbjct: 664 WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723
Query: 981 LILERELDFER-RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG 1039
+ + +++D ER A Y+L + A DGG A+ V V + DVN+N P F +
Sbjct: 724 ICVSQDIDRERDPATYDLLVEAKDGGGLSAQ---AFVRVDLEDVNDN--HPVFNPSTYVT 778
Query: 1040 QVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREF 1099
+ + + GT++I V A D DSG+ G + Y L G + F+I+ TG+I PL
Sbjct: 779 SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
Query: 1100 ASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF----YPSIQEDAPVGTS 1155
++ L V A D G + +V I + P + + + Y + ED+P+GT
Sbjct: 839 STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT- 897
Query: 1156 VLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
+ A +P +SS+ + + I+SG+ G F IHP G + T + LD E + +L V
Sbjct: 898 ---VKAREPLNSSE-PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 953
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGL 1275
P+ ST V + ++DVNDN P F +R+ + P + +Y A D D G
Sbjct: 954 LGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT--ALYLARAEDRDSGR 1010
Query: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATDSGQPPLSASVRLH 1333
NG + YSI F+ID GV+ + + AGE LT++A D G P +A + L
Sbjct: 1011 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 1070
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRP-------GLFWFNISG 1386
+ + R S F+ Y V E+ ++ M ++ + P +++
Sbjct: 1071 V--VIEKREHSPSWTFEHLVYQVEVSES--LSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
Query: 1387 GDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEV---TDGSRTIATQVHIFMIANINH 1443
F I TG I + R D YN V DG + I + + N
Sbjct: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 1186
Query: 1444 HRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDP 1501
+ P FL ++V + VP + ++ AID D GK+ L+Y + F+++P
Sbjct: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL-----LSDGKFFKMNP 1241
Query: 1502 SSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYE 1561
++G L+ LD H +TV+V D+ P + + V + V D N + P F Q
Sbjct: 1242 NTGELINWVALD-REHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 1562 ASVPDTIAPGTE----LLQVRAMDADRGVNAEVHYSL 1594
+ + G + V A D D G NAEV YS+
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 317 bits (813), Expect = 1e-85
Identities = 339/1284 (26%), Positives = 528/1284 (41%), Gaps = 126/1284 (9%)
Query: 2278 TTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKF--FQINGSTGEMSTVQ 2335
T S+ EGLP T V + A + + + + ED D F ++ TG + T +
Sbjct: 70 TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
Query: 2336 ELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
LD E + H+ + L V + V+D+ND+ P F + +VSEL+ G
Sbjct: 130 RLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
Query: 2396 HLVLKVQAIDPDSRDTSRLEYLILS--------------------GNQDRHFFINSSSGI 2435
A DPD+ S Y ++ G SSS +
Sbjct: 184 TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
Query: 2436 ISMFNLCKKHLD----SSYNLRVGASDGVF---RATVPVYINTTNANKYSPEFQQHLYEA 2488
+ + + LD +++ L++ A DG + V + + N P F+Q Y A
Sbjct: 244 EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
Query: 2489 ELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLA------------SEKFSINP-NG 2535
+ E+A G +V + A D+D GP G + Y++ + + F++ +G
Sbjct: 304 AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
Query: 2536 QIATLQKLDRENSTERVIAIKVMARDGGGR--VAFCTVKIILTDENDNPPQFKASEYTVS 2593
+ + LDRE + ++ ARDGG VA V I + D NDN P T
Sbjct: 364 VVRVWRPLDREAQAWHQLVVE--ARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
Query: 2594 IQSNVSKDSP----VIQVLAYDADEGQN-------------ADVTYSVNPEDLVKDVIEI 2636
+ VS+ + V +V DAD D + S++ E D +
Sbjct: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
Query: 2637 N---PVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
P + V+ L + + A D G P ++ + L+V P FS+
Sbjct: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQDP------VIYSLVRGTTP------------ESN 2735
Y S E G+ + V A A + + Y++V+ + P +
Sbjct: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
Query: 2736 KDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRP 2795
F++D ++G I + +D E + ++ V+A L + + V+I V DVNDN P
Sbjct: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
Query: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSES 2854
+F Y A + E+ PVG +QVTA D D+G G + Y L + F ID
Sbjct: 662 IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHD 721
Query: 2855 GWITTLQELDCETCQ-TYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
G I Q++D E TY V A D G LS+QA V+V + D NDN P F Y
Sbjct: 722 GQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVT 778
Query: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
S+ + ++PG + + D D S V + G+ F I I L
Sbjct: 779 SISDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNVSSLFTIDSTTGI--IYLTLPLS 835
Query: 2974 REHTAKYLLRVTASDGK-----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
+ L V+A DG A VT+ IF + + + YT V+EDV
Sbjct: 836 HLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAP--AEFERPKYTFLVYEDVPEDS 893
Query: 3029 FILKVSATDLDTDTNAQITYSLH-GPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKA 3087
I V A + +++ I Y + G +F + P G + T LD E + V L +A
Sbjct: 894 PIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA 952
Query: 3088 TDGGGRSCQA-DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANA 3146
G +C + ++ + V DVNDN P F + + + T T + + A D D G N
Sbjct: 953 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012
Query: 3147 QVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTV 3206
+ YS+ G F+ID GV+ L L Q L LT+RA D G P + L +TV
Sbjct: 1013 LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLVLTV 1071
Query: 3207 SVVGLEDYLP--VFLNTEHSVQVPEDAPPGTEVLQLATLTRP-----GAEKTGYRVVSGN 3259
V+ ++ P F + + V+V E P T++LQ T P A Y +
Sbjct: 1072 -VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ--TQAHPLGPQRAASPLRYSLEPSV 1128
Query: 3260 EQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV-TTVMVNITDVNEHR 3318
+ F + TG +Y+ D+E++ Y + L +V TTV+V + D N++
Sbjct: 1129 DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
Query: 3319 PQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGEL 3378
P F D +V E+ + VI ++A D D N + Y L+ + F ++P GEL
Sbjct: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGEL 1246
Query: 3379 QVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQL----NYSTT 3434
ALDRE + + + TD G PP + + + V D+NDN P F Q
Sbjct: 1247 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 1306
Query: 3435 VQENSPIGSKVLQLILSDPDSPEN 3458
V E P+ V + DPD N
Sbjct: 1307 VLEGQPVNMLVTTVFAKDPDEGNN 1330
Score = 313 bits (801), Expect = 3e-84
Identities = 335/1196 (28%), Positives = 512/1196 (42%), Gaps = 130/1196 (10%)
Query: 2527 EKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQF 2585
+ F ++P+ G I T ++LDRE + A V+I + D ND+ P+F
Sbjct: 114 DDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRF 167
Query: 2586 KASEYTVSIQSNVSKDSPVIQV----LAYDADEGQNADVTYS-VNPEDLVKD----VIEI 2636
S+Q +VS+ SP +A+D D G + Y+ V P DL KD ++
Sbjct: 168 PLD----SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQL 223
Query: 2637 NPVTGVVKVKDSLVGLEN--QTLDFF----------------IKAQDGGPPHWNSLVPVR 2678
T L G + + LD I+A DGG P L+ V
Sbjct: 224 RYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE 283
Query: 2679 LQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA----VAAQDPVIYSLVRGTTPES 2734
L+V+ + + P F + Y + ED G+E+ V+A + V YS+ P +
Sbjct: 284 LRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGA 343
Query: 2735 NKDG-------VFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQV 2787
G F+++ +GV++V +P+D E+ +Q+ V A V+ V V+I V
Sbjct: 344 GSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAV 403
Query: 2788 GDVNDNRP----VFEADPYKAVLTENMPVGTSVIQVTAIDKD---------TGR------ 2828
DVNDNRP +F + A ++E G V +V+ D D TG
Sbjct: 404 LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
Query: 2829 DGQVSYRLSADPGSNVHELFAIDSESGWITTLQ-ELDCETCQTYHFHVVAYDHGQTIQLS 2887
DG +S LS + G L + ++ LD E+ Y +VA D G LS
Sbjct: 464 DGSIS--LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP-PLS 520
Query: 2888 SQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQN----RQVT 2943
++ + + + D ND P F+ + Y+ SV E + PG +V + DAD + + R
Sbjct: 521 TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
Query: 2944 CYITEGDPLGQFGISQV------------GDEWRISSRKTLDREHTAKYLLRVTASD--- 2988
++ LG V + IS+ +TLDRE L+V A D
Sbjct: 581 VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGE 640
Query: 2989 GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITY 3048
A+ V I V DVNDN P + +Y + E GH L+V+A+D D+ I Y
Sbjct: 641 PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
Query: 3049 SLHG-----PGAHEFKLDPHTGELTTLTALDRERKDV-FNLVAKATDGGGRSCQADITLH 3102
SL+ F++DPH G++ +DRER ++L+ +A DGGG S QA + +
Sbjct: 701 SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVD 760
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFS 3161
+EDVNDN P F PS ++ D T T + V A D D G V Y L P + F+
Sbjct: 761 LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 820
Query: 3162 IDATTGVIRLEKPLQVRPQAPLELTVRASDLG-------TPIPLSTLGTVTVSVVGLEDY 3214
ID+TTG+I L PL L L V A D G + + T T++ E
Sbjct: 821 IDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT-TLAPAEFERP 879
Query: 3215 LPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILY 3274
FL E VPED+P GT A +E YR+ SG+ G+F + R G +
Sbjct: 880 KYTFLVYE---DVPEDSPIGTVK---AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933
Query: 3275 VNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENA 3334
LD ET P L+++ S+ + S T V + + DVN++ P F + R+ +
Sbjct: 934 TRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 3335 LVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSL 3394
G + A D D N I YS I Q G F I G L + +L + +L
Sbjct: 993 PPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051
Query: 3395 KLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQ-LNYSTTVQENSPIGSKVLQLILSDP 3453
LRA D G P + + + +P F+ L Y V E+ +++LQ
Sbjct: 1052 TLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL 1111
Query: 3454 DSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQA---SDSGIP 3509
P + + + + F + P GW+ + + Y ++ A D +
Sbjct: 1112 GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
Query: 3510 PLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYS 3567
+S T+V V V +++ +P+ L +F+ V E G++GKI A D D L Y
Sbjct: 1172 NVS--TTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 1229
Query: 3568 LAEEETLGRHFSVGAPDGKII---AAQGLPRGHYSFNVTVSD-GTFTTTAGVHVYV 3619
L + G+ F + G++I A RGH+ V V+D G+ A + VYV
Sbjct: 1230 LLSD---GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
Score = 295 bits (754), Expect = 9e-79
Identities = 349/1278 (27%), Positives = 544/1278 (42%), Gaps = 166/1278 (12%)
Query: 1813 FKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRF 1872
F + P G + +D E + F QV I V DVND PRF
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVA--------ATLLGAVVQVEIRVNDVNDHSPRF 167
Query: 1873 SEQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHP-------- 1920
++ + PG + A D D S Y++ + P
Sbjct: 168 PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
Query: 1921 --------VTGSISVLNPAFLGLSRKLT----------IRASDG-LYQDTALVKISLTQV 1961
+ GS S L P L L R+L I A DG + T L+ + L +V
Sbjct: 228 PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVEL-RV 286
Query: 1962 LDKSLQ---FDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYFL----------- 2005
LD++ F+QD Y AAV+E+ Q + + A L N + Y +
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
Query: 2006 ---LNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIED 2062
L F + + +GV++ DRE Q H+L VE RD VA V +++ D
Sbjct: 347 GGALGDAAYFAVEELSGVVRVWR-PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
Query: 2063 VNDNPPKFKHLPYYT-----IIQDGTEPGDVLFQVSATDED------------LGT---N 2102
VNDN P H+ + T + +G PGD + +VS +D D LG +
Sbjct: 406 VNDNRPAI-HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
Query: 2103 GAVTYEFAEDYTYFRI----DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEE 2158
G+++ F + P + + ++ P D ++ + Y L ++A D G+P L +EE
Sbjct: 465 GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
Query: 2159 VLVTVR--NKSNPLFQSPYYKVRV-----PENITLYTPILHTQARSPEGLRLIYNIVE-E 2210
+L+ V N PLF +YK V P + ++ + L Y +V+
Sbjct: 525 LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 2211 EPLML----------------FTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFS 2254
P L F D ++G ++ LD E + V A D S
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 2255 -EATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVE 2313
V + V+DVNDN P F + VY +I+E P +Q+ ASD DSG + Y + +
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
Query: 2314 D--GSDVSKFFQINGSTGEMSTVQELDYEAQ-QHFHVKVRAMDKGDPPLTGETLVVVNVS 2370
+ + F+I+ G++ Q++D E + + V A D G L+ + V V++
Sbjct: 705 GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLE 762
Query: 2371 DINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFIN 2430
D+NDN P F Y ++S+ G ++ V A D DS + Y ++ GN F I+
Sbjct: 763 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 822
Query: 2431 SSSGIISMFNLCKKHLDS-SYNLRVGASDG-----VFRATVPVYINTTN---ANKYSPEF 2481
S++GII + L HL+S + +L V A DG V A V ++I T A P++
Sbjct: 823 STTGIIYL-TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
Query: 2482 QQHLYEAELAENAMVGT-KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPN-GQIAT 2539
+YE ++ E++ +GT K + L S P I Y I + KFSI+P G I T
Sbjct: 882 TFLVYE-DVPEDSPIGTVKAREPL---NSSEP---IFYRISSGDLGGKFSIHPRLGTIRT 934
Query: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCT-VKIILTDENDNPPQFKASEYTVSIQSNV 2598
+ LD E T+ V+ + V A+ G T V I + D NDN P F + + I
Sbjct: 935 RKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 2599 SKDSPVIQVLAYDADEGQNADVTYSV-NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTL 2657
+ + A D D G+N + YS+ +P+ V I+ GV+ + SL E + L
Sbjct: 993 PPGTALYLARAEDRDSGRNGLIRYSIASPQ---PGVFAIDRALGVLFLNGSLGAGEQREL 1049
Query: 2658 DFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPK--FSEPLYTFSAPEDLPEGSEIGIVKA 2715
++A+D G H + + V V+ K+ P F +Y E L +++ +A
Sbjct: 1050 TLTLRAEDQG-VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
Query: 2716 VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHC---- 2771
S +R + S +F + P TG I +R+ D+EST+ Y V A
Sbjct: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
Query: 2772 -LQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-QVTAIDKDTGRD 2829
LQN +V ++V D NDN P F D + E PV VI ++TAID D+G++
Sbjct: 1169 FLQNVS----TTVIVRVWDENDNSPTFLHD-VLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
GQ+ Y L +D + F ++ +G + LD E + V+ D G + ++
Sbjct: 1224 GQLLYFLLSD-----GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
Query: 2890 ALVQVSITDENDNAPRF----ASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCY 2945
A V VS+TD NDN P F +E V+E LV T+ D D N +VT
Sbjct: 1279 A-VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYS 1336
Query: 2946 ITEGDPLGQFGISQVGDE 2963
++ P+ G + G +
Sbjct: 1337 VSSARPMPLKGKTAFGKQ 1354
Score = 291 bits (744), Expect = 1e-77
Identities = 323/1242 (26%), Positives = 515/1242 (41%), Gaps = 118/1242 (9%)
Query: 2427 FFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLY 2486
F ++ +GII + Y+ G A V V I + N +SP F
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG---AVVQVEIRVNDVNDHSPRFPLDSL 172
Query: 2487 EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQI--------- 2537
+ +++E + GT +A D D+G + T YT++ K P Q+
Sbjct: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
Query: 2538 ----------------ATLQKLDRENSTERVIAIKVMARDGGG--RVAFCTVKIILTDEN 2579
L++LDRE + + I+ A DGG R +V++ + DEN
Sbjct: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIE--AWDGGRPRRTGLLSVELRVLDEN 290
Query: 2580 DNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLV--------- 2630
DNPP F+ EY +++ + + V +V A D D G N V YSV +
Sbjct: 291 DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
Query: 2631 --KDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL 2688
+ ++GVV+V L ++A+DGG + V V + V+ +
Sbjct: 351 GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
Query: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAA----------QDPVIYSLVRGTTPES---- 2734
P T + EG+ G A + +D L G S
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
Query: 2735 --NKDGVFSL----DPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVG 2788
+G F+L P + V P+D ES LY++ ++A + + + ++ ++V
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
Query: 2789 DVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYR-----------LS 2837
D+ND P+F YKA ++E GT V+ V+A D D R L
Sbjct: 531 DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
Query: 2838 ADPGSNVHEL-----FAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALV 2892
+ VH FAIDSESG I+T++ LD E + VVA D G+ LS+ LV
Sbjct: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLV 649
Query: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEG--- 2949
+++ D NDN P F + Y ++ E++ G + DAD S + + +G
Sbjct: 650 SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD-SGLYGFIEYSLYDGFLS 708
Query: 2950 -DPLGQFGISQVGDEWRISSRKTLDREHT-AKYLLRVTASDGK-FQASVTVEIFVLDVND 3006
+ F I + +I + +DRE A Y L V A DG A V + + DVND
Sbjct: 709 YEAPQAFRIDP--HDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL-HGPGAHEFKLDPHTG 3065
N P + Y + ++ PG I+ V ATD D+ + Y L G + F +D TG
Sbjct: 767 NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSC--QADITLHVEDVNDNAPRFFPSHCAVAVF 3123
+ L +L+ A DGGG + AD+T+H+ F V+
Sbjct: 827 IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 886
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
++ +P+ V AR+P + G FSI G IR KPL Q +
Sbjct: 887 EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
Query: 3184 ELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATL 3243
LTV+A P ST V ++V+ + D P FL T +++ + PPGT L LA
Sbjct: 947 VLTVQAQLGSAPACSST--EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT-ALYLARA 1003
Query: 3244 TRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSS 3300
+ + G Y + S + G F +D G+L++N SL + L++ +
Sbjct: 1004 EDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP 1062
Query: 3301 LSDVTTVMVNITDVNEHRPQ--FPQDPYSTRVLENALVGDVILTVSATDEDGPLN--SDI 3356
+ + + V + + EH P F Y V E+ +L A GP S +
Sbjct: 1063 QAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GPQRAASPL 1120
Query: 3357 TYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHE-DTDIAIQ 3415
YSL F I P G + + + D E +Y+ ++ A L T + ++
Sbjct: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 1180
Query: 3416 VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILS-DPDSPENGPPYSFRITKGNNGSA 3474
V D NDN P F V+E SP+ V+ I + D DS +NG F ++ +G
Sbjct: 1181 VWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKF 1236
Query: 3475 FRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVT---EQSHYAPS 3530
F++ P+ G L+ L R + +++ + +D G PP ++ +V V VT + + P
Sbjct: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
Query: 3531 ALP-LEIFITVGEDEFQGGMVGKIHATDRDPQDT--LTYSLA 3569
LP E+ + V E + +V + A D D + +TYS++
Sbjct: 1297 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
Score = 285 bits (728), Expect = 9e-76
Identities = 321/1257 (25%), Positives = 505/1257 (40%), Gaps = 198/1257 (15%)
Query: 47 SPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVV-----------GNFCFL 95
SP+ ++S + L+ P A R + A +F T+ Y + G F L
Sbjct: 164 SPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQL 223
Query: 96 RIRTKS---------SNTAL----------LNREVRDSYTLIIQATEKTLELEA-LTRVV 135
R RT S++ L L+RE ++ L I+A + L V
Sbjct: 224 RYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE 283
Query: 136 VHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTR----- 190
+ +LD+ND P+F YR + ED + +C+V ATD DLG N Y+ R
Sbjct: 284 LRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGA 343
Query: 191 ---------SEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAA 241
+ FA+ SGVV V L+ + H+L V A D + S+A
Sbjct: 344 GSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAV 403
Query: 242 L------------------VVHVEPALRKPPAIASVVVTPPDSND----------GTTYA 273
L V V R +A V V+ D + G
Sbjct: 404 LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
+ + G E + + GG PG F ++ L + L +
Sbjct: 464 DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL-------------LLV 510
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN- 392
+GS P + + F + Y+ +SE + PG+ V+ V + A
Sbjct: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
Query: 393 -----LQYVLKPSSE--NVG---------------FKLNARTGLITTTKLMDFHDRAHYQ 430
L+Y + S N+G F +++ +G I+T + +D + +
Sbjct: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVE 630
Query: 431 LHIRTS-----PGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDR 485
L + P A+ +V I + D N++ P+F R Y+ T+ E+ P G L VTA+D
Sbjct: 631 LKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDA 690
Query: 486 DHGENGYVTYSI-------AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDW 538
D G G++ YS+ P+A F IDP+ G I S+ +D E Y V A D
Sbjct: 691 DSGLYGFIEYSLYDGFLSYEAPQA--FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG 748
Query: 539 GSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE--LQN 596
G + + + L ++NDN P+F SI + G I+ + A D D
Sbjct: 749 GG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 805
Query: 597 LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNI 656
+ YE++ GN F ++ +G+I L P +L + T+ SL ++A DG + ++
Sbjct: 806 VAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL---ESTTLSLMVSAQDGGGLTAVINADV 862
Query: 657 TVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFED 716
T+ H F T L E ++T L
Sbjct: 863 TI----HI--------------FQTT------LAPAEFERPKYTFL-------------- 884
Query: 717 HFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAA 776
V E VP ++P+ + A +P + + Y I+ G+ G F I G +
Sbjct: 885 -------VYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 936
Query: 777 PLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVG 836
PLD+E +L V LG+ S + + V D NDN P F ++ IS+ T G
Sbjct: 937 PLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG 995
Query: 837 TTIAELTTKDADSEDNGRVRYTLLSPTEK-FSLHPLTGELVVTGHLDRESEPRYILKVEA 895
T + +D DS NG +RY++ SP F++ G L + G L + L + A
Sbjct: 996 TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 1055
Query: 896 RDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH--NRLKVPEDLPPGTVLTFLDASDPD 953
DQ V ++I + ++SP EH +++V E L P T + L
Sbjct: 1056 EDQGVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLSPMTQM--LQTQAHP 1110
Query: 954 LGP---AGEVRYVLMDGAHGT-FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLA 1009
LGP A +RY L F + TG + L R+ D+E YN ++A
Sbjct: 1111 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 1170
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY 1069
+ V V V D N+N P F V +V+E+ + + A D DSG +G+L Y
Sbjct: 1171 QNVSTTVIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY 1228
Query: 1070 FLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTD 1129
FL + F +N +TG + LDRE ++ +TVL DRGS P ++ VY+ VTD
Sbjct: 1229 FLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
Query: 1130 ANDNPPQMSQAV----FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYM 1182
NDN P Q + + + E PV V + A DPD + ++T++++S M
Sbjct: 1287 INDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
Score = 262 bits (669), Expect = 6e-69
Identities = 271/972 (27%), Positives = 409/972 (42%), Gaps = 115/972 (11%)
Query: 2697 TFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRK 2753
T S E LP + +G ++A A Q + + +S F + PDTG+I+ +
Sbjct: 70 TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
Query: 2754 PMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVG 2813
+D E Y + T + ++V V I+V DVND+ P F D + ++E P G
Sbjct: 130 RLDRERRDHYSF------VAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
Query: 2814 TSVIQVTAIDKDTGRDGQVSYRL------SADPGSNVHEL---------------FAIDS 2852
T+ A D D G Y L DP +L +
Sbjct: 184 TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
Query: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR 2912
E + L+ LD E + + A+D G+ + + V++ + DENDN P F +EYR
Sbjct: 244 EPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNPPVFEQDEYR 302
Query: 2913 GSVVENSEPGELVATLKTLDADI--------SEQNRQVTCYITEGDPLGQ---FGISQVG 2961
+V E+++PG V ++ D D+ S + RQV + G LG F + ++
Sbjct: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
Query: 2962 DEWRISSRKTLDREHTAKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYT- 3017
R+ + LDRE A + L V A DG + A+V V I VLDVNDN P L T
Sbjct: 363 GVVRVW--RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
Query: 3018 ---GKVHEDVFPGHFILKVSATDLDTDTNAQ---------------ITYSLHGPGAHEFK 3059
+V E PG ++ +VS +D D D + I+ SL G G +F
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG-GEGDFA 479
Query: 3060 L----DPHTGELTTLTALDRERKDVFNLVAKATDGGGR--SCQADITLHVEDVNDNAPRF 3113
L P L LDRE +D++ L+ ATD G S + + L V D+ND P F
Sbjct: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
Query: 3114 FPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQ-------VVYSLP-----------DS 3155
H +V + T V V A D D+ + V S P +
Sbjct: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
Query: 3156 AE--GHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLED 3213
AE F+ID+ +G I + L Q +EL V A DLG P PLS V+++V + D
Sbjct: 600 AECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVND 658
Query: 3214 YLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVV---------SGNEQGRF 3264
P+F ++ + E AP G LQ+ T A+ Y + S F
Sbjct: 659 NEPIFWRQVYNATIAEHAPVGHCFLQV---TASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
Query: 3265 RLDARTGILYVNASLDFETSPK-YFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQ 3323
R+D G + V+ +D E P Y L +E K LS V V++ DVN++ P F
Sbjct: 716 RIDPHDGQICVSQDIDRERDPATYDLLVEA--KDGGGLSAQAFVRVDLEDVNDNHPVFNP 773
Query: 3324 DPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA 3383
Y T + + G I+ V ATD+D + + Y LI GN FTI G + +
Sbjct: 774 STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
Query: 3384 LDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGS 3443
L ++++ SL + A D G + D+ I + P F + Y+ V E+ P S
Sbjct: 834 LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 893
Query: 3444 KVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQ 3502
+ + +P + P +RI+ G+ G F + P G + T + L Q L +Q
Sbjct: 894 PIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 3503 ASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP-- 3560
A G P S T V + V + + P+ L I + + G + A DRD
Sbjct: 952 A-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
Query: 3561 QDTLTYSLAEEE 3572
+ YS+A +
Sbjct: 1011 NGLIRYSIASPQ 1022
Score = 242 bits (617), Expect = 7e-63
Identities = 331/1273 (26%), Positives = 507/1273 (39%), Gaps = 125/1273 (9%)
Query: 2222 TGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
TG++ LD E + + F T LG+ + VE+ V DVND+ P F +
Sbjct: 122 TGIIRTARRLDRERRDHYSFVAA---TLLGAVVQ--VEIRVNDVNDHSPRFPLDSLQLDV 176
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK-----FFQINGST-------- 2328
SE P T +A D D+G Y +V+ SD+ K FFQ+ T
Sbjct: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQP-SDLPKDPAGPFFQLRYRTPGPLPSPL 235
Query: 2329 --GEMSTVQELDY---------EAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPP 2377
G S ++ LD EA H +++ A D G P TG V + V D NDNPP
Sbjct: 236 LPGSSSPLEPLDLVLLRRLDREEAAAH-RLQIEAWDGGRPRRTGLLSVELRVLDENDNPP 294
Query: 2378 EFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSG------------NQDR 2425
F Q +Y A V E A G V +V+A D D + Y + +
Sbjct: 295 VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANKYSPE-- 2480
+F + SG++ ++ + + + L V A DG ATV V I + N P
Sbjct: 355 YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
Query: 2481 --FQQHLYEAELAENAMVGTKVIDLLAIDKDSG-----------PYGTIDYTIINKLASE 2527
F A ++E A G V + D D G D +I L
Sbjct: 415 VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
Query: 2528 K--FSINPNGQ-----IATLQKLDRENSTERVIAIKVMARDGGGRVAFC--TVKIILTDE 2578
+ F++ P G + LDRE + + + ++A D G T+ + + D
Sbjct: 475 EGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
Query: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADE--GQNADVTYSV-------NPEDL 2629
ND PP F Y S+ + + V+ V A DADE +A + Y+V N L
Sbjct: 533 NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
Query: 2630 VKDVIE---------INPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQ 2680
++ I+ +G + +L + ++ + AQD G P ++ V +
Sbjct: 593 QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT 652
Query: 2681 VVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP----VIYSLVRGTTPESNK 2736
V + P F +Y + E P G V A A + YSL G
Sbjct: 653 VDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFL-SYEA 711
Query: 2737 DGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPV 2796
F +DP G I V + +D E D++ + + V + + DVNDN PV
Sbjct: 712 PQAFRIDPHDGQICVSQDIDRERDPA-TYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPV 770
Query: 2797 FEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGW 2856
F Y +++ GT +I V A D+D+G G V+Y L PG NV LF IDS +G
Sbjct: 771 FNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI--PG-NVSSLFTIDSTTGI 827
Query: 2857 ITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVV 2916
I L T V A D G + + A V + I F +Y V
Sbjct: 828 IYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN-ADVTIHIFQTTLAPAEFERPKYTFLVY 886
Query: 2917 ENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDRE 2975
E+ + T+K + + + I+ GD G+F I ++G I +RK LD E
Sbjct: 887 EDVPEDSPIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRLG---TIRTRKPLDHE 941
Query: 2976 HTAKYLLRVTASDGKFQA--SVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKV 3033
+L V A G A S V I V+DVNDN P + ++ + PG +
Sbjct: 942 TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
Query: 3034 SATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGR 3093
A D D+ N I YS+ P F +D G L +L + L +A D G
Sbjct: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
Query: 3094 SCQADITLHVE-DVNDNAPRFFPSHCA--VAVFDNTTVKTPVAVVFARD-PDQGANAQVV 3149
A + L V + +++P + H V V ++ + T + A Q A + +
Sbjct: 1062 PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 1121
Query: 3150 YSLPDSAE-GHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208
YSL S + F I TG I L + V A + TV V V
Sbjct: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV 1181
Query: 3209 VGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGR-FRLD 3267
D P FL+ ++V E++P V+ T + K G + G+ F+++
Sbjct: 1182 WDENDNSPTFLHDVLFLKV-EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMN 1240
Query: 3268 ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQ---- 3323
TG L +LD E + +++ + + S + V V++TD+N++RP FPQ
Sbjct: 1241 PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 3324 DPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA 3383
+VLE V ++ TV A D D N+++TYS+ + P KG+ K
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM------PLKGKTAFGKQ 1354
Query: 3384 LDREQASSYSLKL 3396
++Q + + K+
Sbjct: 1355 SCKKQTNKQTNKI 1367
Score = 231 bits (588), Expect = 2e-59
Identities = 229/879 (26%), Positives = 364/879 (41%), Gaps = 85/879 (9%)
Query: 437 PGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD-----HGENG 491
P +++ + D N+ PLF++ Y ++ E PGT V+ V+A+D D H
Sbjct: 518 PLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLR 577
Query: 492 YVTYSIAGPKAL---------------PFSIDPYLGIISTSKPMDYELMKRIYTFRVRAS 536
Y ++ P L F+ID G IST + +D E+ + + +V A
Sbjct: 578 YTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQ 636
Query: 537 DWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN 596
D G P + + + ++NDN+P+F +I + PVG + ++A D D
Sbjct: 637 DLGEP-PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS--- 692
Query: 597 LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNI 656
+ + + + G +S + P + +I DG+ S +I
Sbjct: 693 --------GLYGFIEYSLYDGFLSYEAP-----------QAFRIDPHDGQICVSQ---DI 730
Query: 657 TVVKDPH-FEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFE 715
+DP +++ V G L S + F + +N P F
Sbjct: 731 DRERDPATYDLLVEAKDGGGL------------------SAQAFVRVDLEDVNDNHPVFN 772
Query: 716 DHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVA 775
+ E+ P T + + ATD D+G G + Y + GN F I+ TG++ +
Sbjct: 773 PSTYVTSISDETQP-GTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLT 831
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
PL + + L V+ D G +T+++ F Y + ED
Sbjct: 832 LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
Query: 836 GTTIAELTTKDA-DSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVE 894
+ I + ++ +S + R + KFS+HP G + LD E++P +L V+
Sbjct: 892 DSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 895 ARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDL 954
A+ + S T++ IT+ DVNDN P + + +++ + PPGT L A D D
Sbjct: 952 AQLGSAPA---CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 1008
Query: 955 GPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLC 1014
G G +RY + G F +D G L L L + L+L A D G + +
Sbjct: 1009 GRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG--VHPQAAL 1066
Query: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGELQYFLRA 1073
V +V++ E+ F V+Q +V E+ TQ++ A L+Y L
Sbjct: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
Query: 1074 GTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV-TEVYIEVTDAND 1132
A F I TG I D E Y V A L +V T V + V D ND
Sbjct: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 1186
Query: 1133 NPPQMSQAVFYPSIQEDAPVGTSVL-QLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT 1191
N P V + ++E +PV V+ ++ A D DS G+L + + S FF ++P T
Sbjct: 1187 NSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNT 1243
Query: 1192 GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRL 1251
G L LDRE++ H + V V D G P +T V V + D+NDN P F L L
Sbjct: 1244 GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 1303
Query: 1252 PERLSPVSPGPVYRLV----ASDLDEGLNGRVTYSIEDS 1286
++ + PV LV A D DEG N VTYS+ +
Sbjct: 1304 HVKV--LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
Score = 177 bits (448), Expect = 3e-43
Identities = 215/758 (28%), Positives = 313/758 (41%), Gaps = 118/758 (15%)
Query: 2966 ISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQ---------CSQLLY 3016
I + + LDRE Y G A V VEI V DVND+SP+ S+L
Sbjct: 125 IRTARRLDRERRDHYSFVAATLLG---AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
Query: 3017 TGK-----VHEDVFPGHFILK----VSATDLDTDTNA---QITYSLHGP------GAHEF 3058
G V D G F + V +DL D Q+ Y GP
Sbjct: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
Query: 3059 KLDPHTGELTTLTALDRERKDVFNLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPS 3116
L+P +L L LDRE L +A DGG R+ + L V D NDN P F
Sbjct: 242 PLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQD 299
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-----PDSAEG--------HFSID 3163
AV ++ V V A D D G N V YS+ P + G +F+++
Sbjct: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
Query: 3164 ATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP----VFL 3219
+GV+R+ +PL QA +L V A D G ++T+ V+++V+ + D P +FL
Sbjct: 360 ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDNRPAIHVLFL 418
Query: 3220 NTEHSVQVPEDAPPGTEVLQLATLTRPGA-----EKTGYRVVSGNEQGRFRLDARTG--- 3271
+V E A PG V +++ G E TG V G G L G
Sbjct: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV-GLGDGSISLSLEGGEGD 477
Query: 3272 ------------ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP 3319
L V LD E+ Y L + + S LS T+++ + D+N+ P
Sbjct: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
Query: 3320 QFPQDPYSTRVLENALVGDVILTVSATDED----------------------GPLNSDIT 3357
F Q Y V E A G V++ VSA+D D G L S +
Sbjct: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
Query: 3358 YSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVA 3417
++ G F I + G + + LDRE + LK+ A D G+PPL ++I V
Sbjct: 598 HTAECGPS---FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
Query: 3418 DVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENG-PPYSF--RITKGNNGSA 3474
DVNDN P F++ Y+ T+ E++P+G LQ+ SD DS G YS A
Sbjct: 655 DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
Query: 3475 FRVTP-DGWLVTAEGLSR-RAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSAL 3532
FR+ P DG + ++ + R R Y L ++A D G LS+ VRV + + + P
Sbjct: 715 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772
Query: 3533 PLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRHFSVGAPDGKIIAA 3590
P ++ ++ G + + ATD+D T+ Y L + F++ + G I
Sbjct: 773 PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGIIYLT 831
Query: 3591 QGLPRGH-----YSFNVTVSDG---TFTTTAGVHVYVW 3620
LP H S V+ DG T A V ++++
Sbjct: 832 --LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
Score = 60.5 bits (145), Expect = 4e-08
Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 8/199 (4%)
Query: 28 SSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEY 87
S +W F H Y + E+ SP T + + + +RY + + +F Y
Sbjct: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 1138
Query: 88 VVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL 147
+ +LR + +T N + + E T V+V + D+ND P
Sbjct: 1139 T--GWIYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 1190
Query: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAG 207
F + + E + I K+TA D D G+N + Y + + F ++P +G +
Sbjct: 1191 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWV 1250
Query: 208 KLNVTWRGKHELQVLAVDR 226
L+ RG HE+ VL DR
Sbjct: 1251 ALDREHRGHHEMTVLVTDR 1269
Score = 49.3 bits (116), Expect = 8e-05
Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)
Query: 401 SENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCNNHA 455
S+ FK+N TG + +D R H+++ + + P A+ V + + D N++
Sbjct: 1232 SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
Query: 456 PLFNRSSYDGTLD----ENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYL 511
P F + L E P V V A D D G N VTYS++ + +P
Sbjct: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAF 1351
Query: 512 GIISTSKPMDYELMK 526
G S K + + K
Sbjct: 1352 GKQSCKKQTNKQTNK 1366
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 378 bits (971), Expect = e-104
Identities = 275/847 (32%), Positives = 420/847 (49%), Gaps = 30/847 (3%)
Query: 2792 DNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAID 2851
+ P F Y+ ++ EN GT+V++V A D D G G++ Y L+A S ELF+ID
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 2852 SESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEY 2911
+SG I T LD E+ + ++ V A DHG +LS+ +V V++ D ND++P F +Y
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQAQY 438
Query: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGD----EWRIS 2967
R ++ EN E G + L+ D D + N + Y G P + + + IS
Sbjct: 439 RETLRENVEEGYPILQLRATDGD-APPNANLR-YRFVGPPAARAAAAAAFEIDPRSGLIS 496
Query: 2968 SRKTLDREHTAKYLLRVTASD-----GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHE 3022
+ +DREH Y L V ASD G A+V V I VLD NDN+PQ S+ Y +V E
Sbjct: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
Query: 3023 DVFPGHFILKVSATDLDTDTNAQITYS-LHGPGAHEFKLDPHTGELTTLTALDRERKDVF 3081
DV P +L+V+ATD D D N + Y+ + G F +D TGE+ + LD E + +
Sbjct: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
Query: 3082 NLVAKATDGGGRSCQAD---ITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFAR 3138
L +A D G + ++ V D+ND+ P F + V+V +N + V + A
Sbjct: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
Query: 3139 DPDQGANAQVVYSLPDSA-EGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP 3197
D D G NA++ YSL A + F I++ TG + + PL V A D G+P P
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP-P 735
Query: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVS 3257
LS +VTV+V+ + D P F E+ +++ EDA GT V+ + + R Y++
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITG 795
Query: 3258 GNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEH 3317
GN + RF + + G+ V +L + + + + + S +L D V +NITD N H
Sbjct: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLT-ASDRALHDHCYVHINITDANTH 854
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGE 3377
RP F YS V E+ +G I+ +SA+D+D N+ ITY L + L F I G
Sbjct: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGA 912
Query: 3378 LQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQE 3437
+ + LD E +Y+L + A D+G P + T + + V DVNDN P+F +Y+ V E
Sbjct: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
Query: 3438 NSPIGSKVLQLILSDPDSPENG-PPYSFRITKGNNGSAFRVTPDGWLV-TAEGLSRRAQE 3495
++P + VLQ+ +D D+ NG Y+F+ + +G F + P +V T L R A
Sbjct: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD-FTIEPTSGIVRTVRRLDREAVS 1031
Query: 3496 WYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHA 3555
Y+L A D G+PPL + S++V V + + AP E + V E+ G +V +I A
Sbjct: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
Query: 3556 TDRD--PQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGL---PRGHYSFNVTVSDGTFT 3610
D D P + Y + E + F + G++ A L R Y V +
Sbjct: 1092 VDPDEGPNAHIMYQIV-EGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLV 1150
Query: 3611 TTAGVHV 3617
+ A VHV
Sbjct: 1151 SRATVHV 1157
Score = 369 bits (947), Expect = e-101
Identities = 297/1005 (29%), Positives = 471/1005 (46%), Gaps = 91/1005 (9%)
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG---PKALP-FSID 508
N P F + +Y + EN GT+VL V A D D GE G + YS+A ++L FSID
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 509 PYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVN 568
P G+I T+ +D E M+R Y RV A D GSP R + + + + ND+ P+FE+
Sbjct: 380 PQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 569 CTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVS-----GNELEYFDLNHFSGVISL 621
++R++ G I+ + A D D N L+Y V F+++ SG+IS
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 622 KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681
+ SY L + ASD P + + V
Sbjct: 498 SG---RVDREHMESYELVVEASDQGQEPGPRSATVRV----------------------- 531
Query: 682 TILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATD 741
++ N PQF + V E V +T + R+ ATD
Sbjct: 532 -------------------HITVLDENDNAPQFSEK-RYVAQVREDVRPHTVVLRVTATD 571
Query: 742 PDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKS 801
D NG + Y I GN G F I+ TG + V APLD+EA Y L + D G P S
Sbjct: 572 RDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLS 631
Query: 802 S-WKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL- 859
+ L ++ V D ND+ P F +Q+++ E+ +G ++ + DAD +N R+ Y+L
Sbjct: 632 NNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 860 -LSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDV 918
++P F ++ TG + V+G LDRES Y VEARD S L + + +T+ DV
Sbjct: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP--PLSASASVTVTVLDV 749
Query: 919 NDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLM 977
NDN P+ + L++ ED GT + + A D D A + Y + G F +
Sbjct: 750 NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA--ISYQITGGNTRNRFAISTQ 807
Query: 978 --TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF 1035
G + L LD+++ + L L ASD A C+V + + D N H P F S
Sbjct: 808 GGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDANT--HRPVFQSA 861
Query: 1036 VHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPL 1095
+ V E+ P G+ ++V++A DDD G + + Y L L F I+ D+G I APL
Sbjct: 862 HYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFRIDADSGAITLQAPL 919
Query: 1096 DREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTS 1155
D E Y L + A D G + T V + V D NDN PQ + + + EDAP TS
Sbjct: 920 DYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTS 979
Query: 1156 VLQLDAWDPDSSSKGKLTFNITSG-NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
VLQ+ A D D+ + G++ + +G + G F I P +G++ T ++LDRE + L
Sbjct: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
+D G P L++ + V + DVNDN P+F + F VR+ E + + V ++ A D DEG
Sbjct: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKE--NSIVGSVVAQITAVDPDEG 1097
Query: 1275 LNGRVTYSI-EDSDEEAFSIDLVTGVVSS--SSTFTAGEYNILTIKATDSGQPPLSASVR 1331
N + Y I E + E F +D+ +G +++ + A + ++ ++AT + PL +
Sbjct: 1098 PNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRAT 1154
Query: 1332 LHIEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGL---FWFNISGG 1387
+H+ + S + F + ++ +D + ++G I P + +++ G
Sbjct: 1155 VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD-PDVSDHLFYSFERG 1213
Query: 1388 DKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQ 1432
++ + +T+G + ++R LD R ++ V VTDG ++ Q
Sbjct: 1214 NELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQ 1258
Score = 369 bits (946), Expect = e-101
Identities = 286/955 (29%), Positives = 471/955 (49%), Gaps = 51/955 (5%)
Query: 2474 ANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI---INKLASEKFS 2530
AN++ P+F Q+ Y+ + EN GT V+ ++A D D+G G + Y++ +N + E FS
Sbjct: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 2531 INP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQFKA 2587
I+P +G I T LDRE+ + +V A+D G T + +T D ND+ P F+
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYL--RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYS-VNP---EDLVKDVIEINPVTGVV 2643
++Y +++ NV + P++Q+ A D D NA++ Y V P EI+P +G++
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 2644 KVKDSLVGLENQTLDFFIKAQDGG--PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAP 2701
+ ++ + ++A D G P ++ V V + V+ + + P+FSE Y
Sbjct: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
Query: 2702 EDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
ED+ + + V A +D LV N G F++D TG I+V P+D E+ +
Sbjct: 556 EDVRPHTVVLRVTA-TDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
Query: 2762 LYQIDVMAHCLQNTDVVSLVSV-NIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
Y + + A + + + +IQV D+ND+ P+F + P++ + EN P+G SVI +
Sbjct: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Query: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDH 2880
A+D D G + ++ Y L+ G F I+S +GW++ LD E+ + Y F V A DH
Sbjct: 675 AVDADHGENARLEYSLT---GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
Query: 2881 GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR 2940
G LS+ A V V++ D NDN P F +EY + E++ G V ++ +D D N
Sbjct: 732 GSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD---ANS 787
Query: 2941 QVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIF 3000
++ IT G+ +F IS G ++ LD + + L +TASD V I
Sbjct: 788 AISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHIN 847
Query: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
+ D N + P Y+ V+ED G I+ +SA+D D NA+ITY L +F++
Sbjct: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE-DNLPQFRI 906
Query: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHC 3118
D +G +T LD E + + L A D G ++ + + V DVNDNAP+F SH
Sbjct: 907 DADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHY 966
Query: 3119 AVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLP--DSAEGHFSIDATTGVIRLEKPLQ 3176
V ++ T V + A D D AN +V Y+ + +G F+I+ T+G++R + L
Sbjct: 967 TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
Query: 3177 VRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTE 3236
+ ELT A D G P PL T ++ V V + D PVF E V+V E++ G+
Sbjct: 1027 REAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
Query: 3237 VLQLATL---TRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC 3293
V Q+ + P A Y++V GN F++D +G L LD+E +Y + ++
Sbjct: 1086 VAQITAVDPDEGPNAH-IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
Query: 3294 SRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGD--------VILTVSA 3345
+S+ L TV V + D N++ P + ++L N V + +I + A
Sbjct: 1145 ---TSAPLVSRATVHVRLVDQNDNSPVL----NNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
Query: 3346 TDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
D D ++ + YS GN+L ++ GEL++++ LD + S+ + TD
Sbjct: 1198 YDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
Score = 364 bits (935), Expect = e-100
Identities = 310/1089 (28%), Positives = 490/1089 (44%), Gaps = 63/1089 (5%)
Query: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFS 2741
P+F + Y PE+ G+ V V AQDP ++YSL S + +FS
Sbjct: 323 PQFPQYNYQTLVPENEAAGTA---VLRVVAQDPDAGEAGRLVYSLAALMNSRSLE--LFS 377
Query: 2742 LDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADP 2801
+DP +G+I+ +D ES + + + V A + + + V + V D ND+ PVFE
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 2802 YKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHEL--FAIDSESGWITT 2859
Y+ L EN+ G ++Q+ A D D + + YR P + F ID SG I+T
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 2860 LQELDCETCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVEN 2918
+D E ++Y V A D GQ S+ V +++ DENDNAP+F+ + Y V E+
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTA 2978
P +V + D D + N V I G+ G F I + E ++ + LD E
Sbjct: 558 VRPHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA--PLDFEAER 614
Query: 2979 KYLLRVTASD-GKFQASVTV---EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVS 3034
+Y LR+ A D G+ S I V+D+ND+ P + V E+ GH ++ +
Sbjct: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Query: 3035 ATDLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGR 3093
A D D NA++ YSL G F ++ TG ++ LDRE + + +A D G
Sbjct: 675 AVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
Query: 3094 --SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYS 3151
S A +T+ V DVNDN P F + + ++ V T V V A D D AN+ + Y
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 3152 LPD-SAEGHFSIDATTGV--IRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208
+ + F+I GV + L PL + + +L + ASD L V +++
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA----LHDHCYVHINI 848
Query: 3209 VGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDA 3268
+ PVF + +SV V ED P G+ ++ ++ E + + +FR+DA
Sbjct: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
Query: 3269 RTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYST 3328
+G + + A LD+E Y L+I +D T V V + DVN++ PQF Y+
Sbjct: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTG 968
Query: 3329 RVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGELQVAKALDRE 3387
V E+A +L +SATD D N + Y+ G G FTI P G ++ + LDRE
Sbjct: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
Query: 3388 QASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQ 3447
S Y L A D G PPL I + V DVNDN P F + V+ENS +GS V Q
Sbjct: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
Query: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDS 3506
+ DPD N ++I +GN F++ G L L A++ Y + +QA+ +
Sbjct: 1089 ITAVDPDEGPNA-HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA 1147
Query: 3507 GIPPLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVGKIHATDRDPQD 3562
PL S +V V + +Q+ +P +I +++ D F G++G+I A D D D
Sbjct: 1148 ---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSD 1204
Query: 3563 TLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGH---YSFNVTVSDGTFTTTAGVHVYV 3619
L YS L + V G++ ++ L S VTV+DG + TA + V
Sbjct: 1205 HLFYSFERGNEL-QLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV 1263
Query: 3620 WHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLDIKRANIHLASLQPAEAVAG 3679
+ +E L ++ + + E +S ++ L ++ + ++Q V G
Sbjct: 1264 VIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGG 1323
Query: 3680 VDVLLVFE---------GHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMPMVPCQGP 3730
+ + F G +G ++ +EL + + RS + ++P
Sbjct: 1324 TVLNVSFSALAPRGAGAGAAGPWFSSEELQEQL------YVRRAALAARSLLDVLPFDDN 1377
Query: 3731 TCQGQICHN 3739
C + C N
Sbjct: 1378 VCLREPCEN 1386
Score = 356 bits (913), Expect = 3e-97
Identities = 295/952 (30%), Positives = 453/952 (47%), Gaps = 53/952 (5%)
Query: 712 PQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA---DGNEEGCFDIELE 768
PQF + Q++ V E+ T + R+ A DPDAG G+LVY +A + F I+ +
Sbjct: 323 PQFPQYNYQTL-VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
Query: 769 TGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLT 828
+GL+ AA LD E+ + L VT D G+P+ S+ ++ V V D ND++P F Y+ T
Sbjct: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
Query: 829 ISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSP-------TEKFSLHPLTGELVVTGHL 881
+ E+ E G I +L D D+ N +RY + P F + P +G + +G +
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
Query: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
DRE Y L VEA DQ + + + IT+ D NDN+PQ + +V ED+ P
Sbjct: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLW 1000
TV+ + A+D D G V Y ++ G + G F +D +TG + + LDFE Y L +
Sbjct: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
Query: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
A D GRP + V+D+N+ H P F S Q V EN+P G VI + A D D
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 1061 SGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV 1120
G + L+Y L F IN TG + PLDRE +Y+ V A D GS PLS+
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSAS 739
Query: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGN 1180
V + V D NDN P+ + ++ + EDA VGTSV+ + A D D++S +++ IT GN
Sbjct: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANS--AISYQITGGN 797
Query: 1181 YMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPP 1240
F I G+ L + K E ++ VL + +L V + I D N + P
Sbjct: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKL-VLTASDRALHDHCYVHINITDANTHRP 856
Query: 1241 IFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVV 1300
+F ++V + E P+ + + ASD D G N R+TY +ED+ + F ID +G +
Sbjct: 857 VFQSAHYSVSVNED-RPMG-STIVVISASDDDVGENARITYLLEDNLPQ-FRIDADSGAI 913
Query: 1301 SSSSTFTAGEY--NILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTV 1358
+ + + L I A D+G P + + ++E + + P F ++Y+ V
Sbjct: 914 TLQAPLDYEDQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAP-QFVASHYTGLV 970
Query: 1359 METDPVNHMVGVISVEGRP----GLFWFNISGG-DKDMDFDIEKTTGSIVIARPLDTRRR 1413
E P V IS R G + G D D DF IE T+G + R LD
Sbjct: 971 SEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAV 1030
Query: 1414 SNYNLTVEVTD-GSRTIATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
S Y LT D G + T V I M+ ++N + P F +EVRV ++++ G + ++
Sbjct: 1031 SVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQIT 1090
Query: 1472 AIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
A+D D+G + ++Y I P LFQ+D SG L + LD ++ ++V+
Sbjct: 1091 AVDPDEGPNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDY---EARQEYVIVVQA 1144
Query: 1530 QEIPIKRNFVWVTIHVE--DGNLHPPRFTQL-----HYEASVPDTIAPGTELLQVRAMDA 1582
P+ T+HV D N + P +Y ++ DT G + ++ A D
Sbjct: 1145 TSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDP 1200
Query: 1583 DRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAED 1634
D V+ + YS +GN +N G + L++KLD ++ V D
Sbjct: 1201 D--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
Score = 333 bits (853), Expect = 3e-90
Identities = 273/950 (28%), Positives = 433/950 (45%), Gaps = 47/950 (4%)
Query: 2168 NPLFQSPYYKVRVPENITLYTPILHTQARSP---EGLRLIYN---IVEEEPLMLFTTDFK 2221
+P F Y+ VPEN T +L A+ P E RL+Y+ ++ L LF+ D +
Sbjct: 322 HPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
Query: 2222 TGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTS 2280
+G++ LD ES +H V A D S T V V V D ND+ P F Q Y +
Sbjct: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
Query: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV---EDGSDVSKFFQINGSTGEMSTVQEL 2337
+ E + P++QL A+D D+ N ++ Y+ V + + F+I+ +G +ST +
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
Query: 2338 DYEAQQHFHVKVRAMDKGDP--PLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
D E + + + V A D+G P + V + V D NDN P+F + +Y A V E
Sbjct: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
Query: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVG 2455
+VL+V A D D + Y I+SGN HF I+S +G I + + Y LR+
Sbjct: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
Query: 2456 ASDG----VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG 2511
A D + T I + N + P F ++ + ENA +G VI + A+D D G
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 2512 PYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGG--RVAF 2568
++Y++ F IN G ++ LDRE+ ++ ARD G A
Sbjct: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE--ARDHGSPPLSAS 739
Query: 2569 CTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPED 2628
+V + + D NDN P+F EY + + + + + V+ V A D D N+ ++Y + +
Sbjct: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN 797
Query: 2629 LVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL 2688
++ I+ GV V +L L+ + +F + V + +
Sbjct: 798 -TRNRFAISTQGGVGLVTLAL-PLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHR 855
Query: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVIYSLVRGTTPESNKDGVFSLDPD 2745
P F Y+ S ED P GS I ++ A ++ I L+ P+ F +D D
Sbjct: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ------FRIDAD 909
Query: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAV 2805
+G I ++ P+D+E Y + + A V + V DVNDN P F A Y +
Sbjct: 910 SGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGL 969
Query: 2806 LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDC 2865
++E+ P TSV+Q++A D+D +G+V Y + G + F I+ SG + T++ LD
Sbjct: 970 VSEDAPPFTSVLQISATDRDAHANGRVQY--TFQNGEDGDGDFTIEPTSGIVRTVRRLDR 1027
Query: 2866 ETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELV 2925
E Y A D G L + +QV + D NDNAP F +EE+ V ENS G +V
Sbjct: 1028 EAVSVYELTAYAVDRG-VPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT 2985
A + +D D N + I EG+ F + E +++ LD E +Y++ V
Sbjct: 1087 AQITAVDPD-EGPNAHIMYQIVEGNIPELFQMDIFSGE--LTALIDLDYEARQEYVIVVQ 1143
Query: 2986 ASDGKFQASVTVEIFVLDVNDNSPQCS--QLLYTGKV--HEDVFPGHFILKVSATDLDTD 3041
A+ + TV + ++D NDNSP + Q+L+ V D FP I ++ A D D
Sbjct: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA--YDPD 1201
Query: 3042 TNAQITYSL-HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDG 3090
+ + YS G ++ +GEL LD R V +++ TDG
Sbjct: 1202 VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 323 bits (828), Expect = 2e-87
Identities = 261/956 (27%), Positives = 438/956 (45%), Gaps = 66/956 (6%)
Query: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL---LKGNSEGFFNINALL 1609
P+F Q +Y+ VP+ A GT +L+V A D D G + YSL + S F+I+
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1610 GIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669
G+I A LD+ + H L V A+D GSP+ V + V + +P+F +++Y +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 1670 PESIPVGSPILLVSAM---SPSEVTYELR-------EGNKDGVFSMNSYSGLISTQKKLD 1719
E++ G PIL + A +P R F ++ SGLIST ++D
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
Query: 1720 HEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775
E + SY+L + +G V V + ++DENDNAP F + +V Q+ E ++
Sbjct: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
Query: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPS 1835
+++ + A+D DK+AN L+ Y I+ + F ID G + +V+ +D+E+
Sbjct: 563 VVLR-------VTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
Query: 1836 FQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVR 1895
+ + D G P L + I V D+ND P F ++V+++ G ++ ++
Sbjct: 616 YALRIRAQDAGRPPL-SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Query: 1896 ASD----EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPA--------FLGLSRKLTIRA 1943
A D E++ + YS+ D I+ TG +SV P F G+ +
Sbjct: 675 AVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR--DHG 732
Query: 1944 SDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSY 2003
S L +A V +++ V D +F Y + E+ ++V + A N +SY
Sbjct: 733 SPPL-SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISY 791
Query: 2004 FLLNGT--DMFHMVQSAGV-LQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI 2060
+ G + F + GV L T + D +Q+ +L + D V ++I
Sbjct: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHC---YVHINI 848
Query: 2061 EDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDP 2120
D N + P F+ Y + + G + +SA+D+D+G N +TY ++ FRID
Sbjct: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
Query: 2121 YLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE--EVLVTVRNKSNPLFQSPYYKV 2178
G I+L+ P DY+ Y L + ARD G P EV+V N + P F + +Y
Sbjct: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTG 968
Query: 2179 RVPENITLYTPILHTQARSPEGL---RLIYNIVE-EEPLMLFTTDFKTGVLTVTGPLDYE 2234
V E+ +T +L A + R+ Y E+ FT + +G++ LD E
Sbjct: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
Query: 2235 SKTKHVFTVRATDTALGSF-SEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQ 2293
+ + + T A D + + +++V+V+DVNDN P F + + E + V Q
Sbjct: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
Query: 2294 LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
+ A D D G N + YQIVE ++ + FQ++ +GE++ + +LDYEA+Q + + V+A
Sbjct: 1089 ITAVDPDEGPNAHIMYQIVE--GNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT- 1145
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQ-----YEANVSELATCGHLVLKVQAIDPDS 2408
PL V V + D NDN P Q Y +N S+ G ++ ++ A DPD
Sbjct: 1146 --SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDV 1202
Query: 2409 RDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRAT 2464
D L Y GN+ + +N +SG + + + ++ V +DG+ T
Sbjct: 1203 SD--HLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVT 1256
Score = 310 bits (794), Expect = 2e-83
Identities = 275/989 (27%), Positives = 444/989 (44%), Gaps = 80/989 (8%)
Query: 1658 PIFSKSEYFVEIPESIPVGSPILLVSAMSPS-----EVTYELR---EGNKDGVFSMNSYS 1709
P F + Y +PE+ G+ +L V A P + Y L +FS++ S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1710 GLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMF----LKS 1761
GLI T LD E + + L++ GS A T MV V + D ND++P+F +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATT--MVAVTVADRNDHSPVFEQAQYRE 440
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKF-----FKID 1816
T + E P+ + A+D D N+ L Y+ + P A + F+ID
Sbjct: 441 TLRENVEEGYPILQL-----------RATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
Query: 1817 PSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVR--DVNDSPPRFSE 1874
P G ++ +D E M S++ V DQG PR A V +H+ D ND+ P+FSE
Sbjct: 490 PRSGLISTSGRVDREHMESYELVVEASDQGQEP--GPRSATVRVHITVLDENDNAPQFSE 547
Query: 1875 QIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNP 1930
+ Y + + P +L V A+D D + N Y+I +GN+ I +TG I V+ P
Sbjct: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP 607
Query: 1931 AFLGLSRK--LTIRASDG----LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDR 1984
R+ L IRA D L +T L I + + D F + +V EN
Sbjct: 608 LDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLG 667
Query: 1985 KALV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE 2041
+++ I +H + + L G D ++ SA + DRE + + VE
Sbjct: 668 HSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
Query: 2042 VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGT 2101
RD+ +P A V V++ DVNDN P+F Y+ + + G + V+A D D
Sbjct: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
Query: 2102 NGAVTYEFAEDYTYFRI----DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE 2157
N A++Y+ T R +G ++L P DY+ + L + A D
Sbjct: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD-HCYV 844
Query: 2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSP---EGLRLIYNIVEEEPLM 2214
+ +T N P+FQS +Y V V E+ + + I+ A E R+ Y + E+ L
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLP 902
Query: 2215 LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFS 2273
F D +G +T+ PLDYE + + + A D + ++ T VEV+V DVNDN P F
Sbjct: 903 QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962
Query: 2274 QLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMST 2333
YT +SE P T V+Q+ A+D+D+ N V Y ++G D F I ++G + T
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF-QNGEDGDGDFTIEPTSGIVRT 1021
Query: 2334 VQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELAT 2393
V+ LD EA + + A+D+G PPL + V V D+NDN P F ++E V E +
Sbjct: 1022 VRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
Query: 2394 CGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLR 2453
G +V ++ A+DPD + + Y I+ GN F ++ SG ++ Y +
Sbjct: 1082 VGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIV 1141
Query: 2454 VGASDGVFRATVPVYINTTNANKYSPEFQ--QHLYEAELAENAMVGTKVI--DLLAIDKD 2509
V A+ + V++ + N SP Q L+ ++ + I + A D D
Sbjct: 1142 VQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
Query: 2510 SGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRV-A 2567
+ + N+L + +N +G++ +KLD N+ V ++ V DG V A
Sbjct: 1202 VSDHLFYSFERGNEL--QLLVVNQTSGELRLSRKLD--NNRPLVASMLVTVTDGLHSVTA 1257
Query: 2568 FCTVKIILTDENDNPPQFKASEYTVSIQS 2596
C +++++ E + A+ TV +++
Sbjct: 1258 QCVLRVVIITE-----ELLANSLTVRLEN 1281
Score = 293 bits (750), Expect = 3e-78
Identities = 243/835 (29%), Positives = 391/835 (46%), Gaps = 61/835 (7%)
Query: 1130 ANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT---SGNYMGFFM 1186
A + PQ Q + + E+ GT+VL++ A DPD+ G+L +++ + + F
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 1187 IHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKL 1246
I P +GL+ TA LDRE+ + H L VT D+G P L +T+ V V + D ND+ P+F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 1247 FNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTY------SIEDSDEEAFSIDLVTGVV 1300
+ L E + P+ +L A+D D N + Y + + AF ID +G++
Sbjct: 438 YRETLRENVE--EGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 1301 SSSSTFTAG--EYNILTIKATDSGQP--PLSASVRLHIEWIPWPRPSSIPLAFDETYYSF 1356
S+S E L ++A+D GQ P SA+VR+HI + + P F E Y
Sbjct: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVL--DENDNAP-QFSEKRYVA 552
Query: 1357 TVMETDPVNHMVGVISVEGRP----GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRR 1412
V E + +V ++ R GL +NI G+ F I+ TG I + PLD
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 1413 RSNYNLTVEVTDGSR---TIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
Y L + D R + T + + +IN H P F+ T ++V V ++ G ++
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 1470 VQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMV 1527
+QA+D D G++ L Y++ G + F ++ ++G + G LD S + V
Sbjct: 673 IQAVDADHGENARLEYSLTG---VAPDTPFVINSATGWVSVSGPLDRES-VEHYFFGVEA 728
Query: 1528 RDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVN 1587
RD P VT+ V D N + P FT Y + + A GT ++ V A+D D N
Sbjct: 729 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--AN 786
Query: 1588 AEVHYSLLKGNSEGFFNINAL--LGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+ + Y + GN+ F I+ +G++TLA LD L + A D+ HD
Sbjct: 787 SAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCY 843
Query: 1646 VIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKD 1700
V I++ ++ P+F + Y V + E P+GS I+++SA + +TY L +
Sbjct: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ 903
Query: 1701 GVFSMNSYSGLISTQKKLDHEKISSYQLKI--RGSNMAGAFTDVMVVVDIIDENDNAPMF 1758
F +++ SG I+ Q LD+E +Y L I R + + V V + D NDNAP F
Sbjct: 904 --FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF 961
Query: 1759 LKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPE-ALKFFKIDP 1817
+ S + G +SE AP ++ ++ I A+D D AN + Y E F I+P
Sbjct: 962 VASHYTGLVSEDAPPFTSVLQ-------ISATDRDAHANGRVQYTFQNGEDGDGDFTIEP 1014
Query: 1818 SMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY 1877
+ G + V +D E++ ++ Y D+G P L P QV+ V+DVND+ P F + +
Sbjct: 1015 TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVM--VQDVNDNAPVFPAEEF 1072
Query: 1878 EVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVL 1928
EV + G + + A D D + + Y I GN E + +G ++ L
Sbjct: 1073 EVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL 1127
Score = 281 bits (720), Expect = 8e-75
Identities = 260/997 (26%), Positives = 425/997 (42%), Gaps = 130/997 (13%)
Query: 146 PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF----NTRS-EMFAIHPTS 200
P F +Y+ + E+ + + +V A D D G+ Y+ N+RS E+F+I P S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 201 GVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV 260
G++ A L+ +H L+V A D H P L A V
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQD-------------------HGSPRLS---ATTMVA 420
Query: 261 VTPPDSNDGTT------YATVLVDANSSGAEVESVEVVGGD--------------PGKHF 300
VT D ND + Y L + G + + GD P
Sbjct: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA 480
Query: 301 KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARS-GSGPYFYSQIRGFHLP--PSKL 357
A ++ L+S E++ + L ++A G P S H+
Sbjct: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
Query: 358 SSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN----LQYVLKPSSENVGFKLNARTG 413
++ +F + Y Q+ E P + V+ V T + + Y + + F +++ TG
Sbjct: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
Query: 414 LITTTKLMDFHDRAHYQLHIRTSPG------QASTVVVIDIVDCNNHAPLFNRSSYDGTL 467
I +DF Y L IR + + I +VD N+H P+F + + ++
Sbjct: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAG-PKALPFSIDPYLGIISTSKPMDYELMK 526
EN P G SV+ + A D DHGEN + YS+ G PF I+ G +S S P+D E ++
Sbjct: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE 720
Query: 527 RIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTM 586
Y F V A D GSP S+ + + ++NDN+P F + +D VG S++++
Sbjct: 721 H-YFFGVEARDHGSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSV 778
Query: 587 SAIDVDELQNLKYEIVSGNELEYFDLNHFSGV--ISLKRPFINLTAGQPTSYSLKITASD 644
+A+D D + Y+I GN F ++ GV ++L P L Q + L +TASD
Sbjct: 779 TAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALP---LDYKQERYFKLVLTASD 835
Query: 645 GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
LH D + ++
Sbjct: 836 -------------------------------------RALH----------DHCYVHINI 848
Query: 705 YQINHYTPQFED-HFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCF 763
N + P F+ H+ S+ V E P+ + + ++A+D D G N ++ Y++ D + F
Sbjct: 849 TDANTHRPVFQSAHY--SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
Query: 764 DIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG 823
I+ ++G +T+ APLDYE Y L +T D G PQK+ + V V D NDNAP+F
Sbjct: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVAS 964
Query: 824 GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGH 880
Y +SED T++ +++ D D+ NGRV+YT + + F++ P +G +
Sbjct: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
Query: 881 LDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940
LDRE+ Y L A D+ L + + + ++DVNDN+P E ++V E+
Sbjct: 1025 LDREAVSVYELTAYAVDRGVP--PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
Query: 941 GTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSL 999
G+V+ + A DPD GP + Y +++G F++D+ +G L +LD+E R Y + +
Sbjct: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVV 1142
Query: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059
A+ PL R HV ++ D N+N + + V S + I+
Sbjct: 1143 QATSA--PLVSRATVHVRLV--DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAY 1198
Query: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLD 1096
D + L Y G L +NQ +G ++ LD
Sbjct: 1199 DPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
Score = 242 bits (617), Expect = 7e-63
Identities = 248/974 (25%), Positives = 422/974 (43%), Gaps = 141/974 (14%)
Query: 105 ALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPL 163
A L+RE + + L + A + + L A T V V + D+ND P+F YR T+ E++
Sbjct: 389 AALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEE 448
Query: 164 KSPICKVTATDADLGQNAEFYYAF-------NTRSEMFAIHPTSGVVTVAGKLNVTWRGK 216
PI ++ ATD D NA Y F + F I P SG+++ +G+++
Sbjct: 449 GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMES 508
Query: 217 HELQVLAVDRMRKISEGNGFGSLAALV-VHVE--------PALRKPPAIASVVVTPPDSN 267
+EL V A D +G G +A V VH+ P + +A V
Sbjct: 509 YELVVEASD------QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV------RE 556
Query: 268 DGTTYATVL----VDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM 323
D + VL D + + ++ G+ HF AI S + E +V+ D
Sbjct: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHF-AIDSL--TGEIQVVAPLDF--- 610
Query: 324 EYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLK----------FEKAVYRVQLSE 373
E + L ++A+ P + + L+S++ F ++V + E
Sbjct: 611 EAEREYALRIRAQDAGRPPLSNN--------TGLASIQVVDINDHIPIFVSTPFQVSVLE 662
Query: 374 FSPPGSRVVMVRVTPAF----PNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHY 429
+P G V+ ++ A L+Y L + + F +N+ TG ++ + +D HY
Sbjct: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
Query: 430 QLHIR-----TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATD 484
+ + P AS V + ++D N++ P F Y L+E+ GTSV++VTA D
Sbjct: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
Query: 485 RDHGENGYVTYSIAGPKA---LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSP 541
RD N ++Y I G S +G+++ + P+DY+ +R + + ASD
Sbjct: 783 RD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK-QERYFKLVLTASDRAL- 838
Query: 542 FRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEI 601
+ + + + N ++P+F+ + + S+ +D P+G +I+ +SA D D +N +
Sbjct: 839 ---HDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY 895
Query: 602 VSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASD-GKNYASPTTLNITVVK 660
+ + L F ++ SG I+L+ P L +Y+L ITA D G + TT +V
Sbjct: 896 LLEDNLPQFRIDADSGAITLQAP---LDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN 952
Query: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQ 720
D + P QF + H+ GL
Sbjct: 953 DVNDNAP----------QFVAS--HYTGL------------------------------- 969
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLD 779
V E P T + +++ATD DA NG++ Y +G + +G F IE +G++ LD
Sbjct: 970 ---VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
Query: 780 YEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI 839
EA + Y L D G P + + V V+D NDNAP FP +++ + E++ VG+ +
Sbjct: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 840 AELTTKDADSEDNGRVRYTLLSPT--EKFSLHPLTGELVVTGHLDRESEPRYILKVEARD 897
A++T D D N + Y ++ E F + +GEL LD E+ Y++ V+A
Sbjct: 1087 AQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
Query: 898 QPSKGHQLFSVTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPD 953
P L S + + L D NDNSP I +N + D P ++ + A DPD
Sbjct: 1147 AP-----LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
Query: 954 LGPAGEVRYVLMDGAH-GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRT 1012
+ + + Y G V+ +G L L R+LD R ++ + +DG + +
Sbjct: 1202 V--SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQC 1259
Query: 1013 LCHVEVIVLDVNEN 1026
+ V +I ++ N
Sbjct: 1260 VLRVVIITEELLAN 1273
Score = 233 bits (595), Expect = 2e-60
Identities = 237/959 (24%), Positives = 416/959 (43%), Gaps = 112/959 (11%)
Query: 1240 PIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSI----EDSDEEAFSIDL 1295
P F + +PE + + V R+VA D D G GR+ YS+ E FSID
Sbjct: 323 PQFPQYNYQTLVPE--NEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDP 380
Query: 1296 VTGVVSSSSTFT--AGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+G++ +++ + E + L + A D G P LSA+ + + S + F++
Sbjct: 381 QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV---FEQAQ 437
Query: 1354 YSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD--------------------F 1393
Y T+ E EG P + + GD + F
Sbjct: 438 YRETLRENVE----------EGYP-ILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAF 486
Query: 1394 DIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-----GSRTIATQVHIFMIANINHHRPQF 1448
+I+ +G I + +D +Y L VE +D G R+ +VHI ++ N + PQF
Sbjct: 487 EIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDE-NDNAPQF 545
Query: 1449 LETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLI--YTIHGSQDPGSASLFQLDPSSGVL 1506
E RY +V +D P +LRV A D+DK + + Y I G F +D +G +
Sbjct: 546 SEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGH---FAIDSLTGEI 602
Query: 1507 VTVGKLDLGSGPSQHTLTVMVRDQ-EIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVP 1565
V LD ++ L + +D P+ N +I V D N H P F ++ SV
Sbjct: 603 QVVAPLDF-EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
Query: 1566 DTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAP 1625
+ G ++ ++A+DAD G NA + YSL + F IN+ G ++++ LD+ +
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 1626 HTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAM 1685
+ V+A D GSP A+V + V + + P F+ EY + + E VG+ ++ V+A+
Sbjct: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 1686 ---SPSEVTYELREGNKDGVFSMNSYS--GLISTQKKLDHEKISSYQLKIRGSNMAGAFT 1740
+ S ++Y++ GN F++++ GL++ LD+++ ++L + S+ A
Sbjct: 782 DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHD 840
Query: 1741 DVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLL 1800
V ++I D N + P+F + + ++E P+ S I+ VI ASD D N+ +
Sbjct: 841 HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV-------VISASDDDVGENARI 893
Query: 1801 VYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVII 1860
Y L + L F+ID G +T+ + +DYE ++ + D G P V +
Sbjct: 894 TY--LLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ--KADTTYVEV 949
Query: 1861 HVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTG-NADEA 1915
V DVND+ P+F Y + P +L + A+D D+ N Y+ + G + D
Sbjct: 950 MVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD 1009
Query: 1916 VTIHPVTGSISVLNPAFLGLSRKLTIRASDGLYQDTAL--------------VKISLTQV 1961
TI P +G + + R+L R + +Y+ TA +++ + V
Sbjct: 1010 FTIEPTSGIVRTV--------RRLD-REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDV 1060
Query: 1962 LDKSLQFDQDVYWAAVKEN--LQDRKALVILGAQGNHLNDTLSYFLLNGT--DMFHMVQS 2017
D + F + + VKEN + A + N + Y ++ G ++F M
Sbjct: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIF 1120
Query: 2018 AGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPY-- 2075
+G L D + + E + V+ P V++ V V + D NDN P +
Sbjct: 1121 SGELT---ALIDLDYEARQEYVIVVQATSAP-LVSRATVHVRLVDQNDNSPVLNNFQILF 1176
Query: 2076 --YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFD 2132
Y + T P ++ ++ A D D+ + ++E + ++ G++ L + D
Sbjct: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
Score = 172 bits (436), Expect = 7e-42
Identities = 204/847 (24%), Positives = 354/847 (41%), Gaps = 100/847 (11%)
Query: 63 AEPQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQAT 122
A P +RYR + A + + L S + ++RE +SY L+++A+
Sbjct: 462 APPNANLRYRFVGPPAARAAAAAAFEIDPRSGL-----ISTSGRVDREHMESYELVVEAS 516
Query: 123 EKTLE---LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQ 179
++ E A RV + +LD+ND P FS Y + ED+ + + +VTATD D
Sbjct: 517 DQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDA 576
Query: 180 NAEFYY---AFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMR-KISEGNG 235
N +Y + N+R FAI +G + V L+ ++ L++ A D R +S G
Sbjct: 577 NGLVHYNIISGNSRGH-FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635
Query: 236 FGSLAALVV--HVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVG 293
S+ + + H+ P P SV+ P + V D + S+ V
Sbjct: 636 LASIQVVDINDHI-PIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVA 694
Query: 294 GDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARS-GSGPYFYSQIRGFHL 352
D + ++ VSV E + + ++AR GS P S +
Sbjct: 695 PD--------TPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTV 746
Query: 353 PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN--LQYVLKPSSENVGFKLNA 410
+ +F Y ++L+E + G+ VV V N + Y + + F ++
Sbjct: 747 LDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAIST 806
Query: 411 R--TGLITTTKLMDFHDRAHYQLHIRTSPG--QASTVVVIDIVDCNNHAPLFNRSSYDGT 466
+ GL+T +D+ +++L + S V I+I D N H P+F + Y +
Sbjct: 807 QGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVS 866
Query: 467 LDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYLGIISTSKPMDYELM 525
++E+ P G++++ ++A+D D GEN +TY + LP F ID G I+ P+DYE
Sbjct: 867 VNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYE-D 923
Query: 526 KRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
+ YT + A D G P ++ + + + ++NDN P F + TG + +D P S++
Sbjct: 924 QVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQ 982
Query: 586 MSAIDVDELQN--LKYEIVSGNELE-YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITA 642
+SA D D N ++Y +G + + F + SG++ R L + Y L A
Sbjct: 983 ISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR---RLDREAVSVYELTAYA 1039
Query: 643 SDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTS 701
D T ++I V V+D + PV EEF
Sbjct: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPV-------------------------FPAEEF-- 1072
Query: 702 LSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEG 761
+ V E+ + + +A++ A DPD G N ++Y I +GN
Sbjct: 1073 -------------------EVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPE 1113
Query: 762 CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFP 821
F +++ +G LT LDYEA Y++ V +++ + V + D NDN+P
Sbjct: 1114 LFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQNDNSPVL- 1169
Query: 822 PGGYQLTIS------EDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGEL 875
+Q+ + DT I + D D D+ + + + ++ +GEL
Sbjct: 1170 -NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGEL 1228
Query: 876 VVTGHLD 882
++ LD
Sbjct: 1229 RLSRKLD 1235
Score = 159 bits (403), Expect = 4e-38
Identities = 212/809 (26%), Positives = 331/809 (40%), Gaps = 138/809 (17%)
Query: 27 SSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEE 86
+ +A F+ Y A + E+ P T V + V Y IISG+
Sbjct: 539 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD-KDANGLVHYNIISGNSR------- 590
Query: 87 YVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE-LEALTRVV-VHILDQNDL 144
G+F + + A L+ E Y L I+A + L T + + ++D ND
Sbjct: 591 ---GHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDH 647
Query: 145 KPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFN--TRSEMFAIHPTSGV 202
P+F ++V++ E+ PL + + A DAD G+NA Y+ F I+ +G
Sbjct: 648 IPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGW 707
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVT 262
V+V+G L+ R+ E FG A H P L A ASV VT
Sbjct: 708 VSVSGPLD-----------------RESVEHYFFGVEAR--DHGSPPLS---ASASVTVT 745
Query: 263 PPDSND--------------------GTTYATVLV---DANSSGAEVESVEVVGGDPGKH 299
D ND GT+ +V DANS+ S ++ GG+
Sbjct: 746 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA----ISYQITGGNTRNR 801
Query: 300 FKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGS-GPYFYSQIRGFHLPPSKLS 358
F AI + +L D Y F L L A + + Y I ++ +
Sbjct: 802 F-AISTQGGVGLVTLALPLDYKQERY---FKLVLTASDRALHDHCYVHI---NITDANTH 854
Query: 359 SLKFEKAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLNARTGL 414
F+ A Y V ++E P GS +V++ + + Y+L+ + F+++A +G
Sbjct: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGA 912
Query: 415 ITTTKLMDFHDRAHYQLHIRTS----PGQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDE 469
IT +D+ D+ Y L I P +A T V + + D N++AP F S Y G + E
Sbjct: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
Query: 470 NIPPGTSVLAVTATDRDHGENGYVTYSIAGPK--ALPFSIDPYLGIISTSKPMDYELMKR 527
+ PP TSVL ++ATDRD NG V Y+ + F+I+P GI+ T + +D E +
Sbjct: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVS- 1031
Query: 528 IYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMS 587
+Y A D G P R VSI + ++++NDN P+F ++++ VG + ++
Sbjct: 1032 VYELTAYAVDRGVPPLR-TPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQIT 1090
Query: 588 AIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
A+D DE N + Y+IV GN E F ++ FSG ++ I+L Y + + A+
Sbjct: 1091 AVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELT---ALIDLDYEARQEYVIVVQAT-- 1145
Query: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
++P TV H + D + VL F
Sbjct: 1146 ---SAPLVSRATV----HVRLVDQNDNSPVLNNF------------------------QI 1174
Query: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
N+Y D FP I + R+ A DPD + L Y GNE +
Sbjct: 1175 LFNNYVSNRSDTFPSGI-----------IGRIPAYDPDV--SDHLFYSFERGNELQLLVV 1221
Query: 766 ELETGLLTVAAPLDYEATNFYILNVTVYD 794
+G L ++ LD + VTV D
Sbjct: 1222 NQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
Score = 77.4 bits (189), Expect = 3e-13
Identities = 49/145 (33%), Positives = 69/145 (47%), Gaps = 14/145 (9%)
Query: 3944 CCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRE--NCTFAPCLEGGTC 4001
C D C N C NGG C+ G GY C C P+F+G+ CE E C C GGTC
Sbjct: 1432 CETELDLCYSNPCRNGGACARREG-GYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTC 1490
Query: 4002 ILSPKGA-SCNCP--HPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAF 4058
+P G C CP + G RCE+ AR ++ G ++ +T++++F
Sbjct: 1491 TDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFR-------GLRQRFHLTLSLSF 1543
Query: 4059 IIISTVGLLFYCRRC-KSHKPVAME 4082
+ GLLFY R + H +A+E
Sbjct: 1544 ATVQQSGLLFYNGRLNEKHDFLALE 1568
Score = 59.3 bits (142), Expect = 8e-08
Identities = 28/68 (41%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 3968 AGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEM--EA 4025
AG C+CPP F+G CE + C PC GG C G +C C +TG+ CE+ EA
Sbjct: 1417 AGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEA 1476
Query: 4026 RGCSEGHC 4033
C G C
Sbjct: 1477 GRCVPGVC 1484
Score = 46.2 bits (108), Expect = 7e-04
Identities = 53/199 (26%), Positives = 77/199 (38%), Gaps = 32/199 (16%)
Query: 3841 LSSQRHVNDHEWHSILVE--EMDASIR----LMVD---SMGNTSLVVPENCRGLRPERHL 3891
L Q V+D WH + +E E R LMV S+ ++ V +GL+ ++ L
Sbjct: 1837 LLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQ-L 1895
Query: 3892 LLGGLILLHSSSNVSQGFEGCLDAVVVNEEALD---LLAPGKTVAGLLETQALTQCCLHS 3948
+GGL S+ QG GC+ V + LL P V C+ +
Sbjct: 1896 HVGGLPP-GSAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNA-------EPGCVVT 1947
Query: 3949 DYCSQNTCLNGGKCS--WTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCIL--- 4003
+ C+ C C W + C C P + G C C PC G+C
Sbjct: 1948 NACASGPCPPHADCRDLWQT---FSCTCQPGYYGPGCVDA---CLLNPCQNQGSCRHLPG 2001
Query: 4004 SPKGASCNCPHPYTGDRCE 4022
+P G +C+C Y G CE
Sbjct: 2002 APHGYTCDCVGGYFGHHCE 2020
Score = 44.7 bits (104), Expect = 0.002
Identities = 63/259 (24%), Positives = 104/259 (40%), Gaps = 58/259 (22%)
Query: 3771 CNGTATRFSGQSYVRYRAPAARNWHIHFYLK--TLQPQAILLFTNETAS----VSLKLAS 3824
C A F S+V +R R +H+ L T+Q +L + ++L+L +
Sbjct: 1513 CEVAARSFPPSSFVMFRGLRQR-FHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVA 1571
Query: 3825 GVPQLEYHCLGGFYGNLSSQR---HVNDHEWHSI-------------------------- 3855
G +L Y G + S ++D +WH++
Sbjct: 1572 GQVRLTYST--GESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAV 1629
Query: 3856 -LVEEMDASIRLMVDS-MGNTSL----VVPENCRGLRPERHLLLGGLILLHSSSNVS-QG 3908
V++ D ++ L + +GN S V + + L LLLGG+ L + VS +
Sbjct: 1630 LSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKD 1689
Query: 3909 FEGCLDAVVVNEEALDL---LAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWT 3965
F GC+ + ++ +D+ +A T+AG Q LH +C C N G CS
Sbjct: 1690 FIGCMRDLHIDGRRVDMAAFVANNGTMAGC-------QAKLH--FCDSGPCKNSGFCSER 1740
Query: 3966 HGAGYVCKCPPQFSGKHCE 3984
G+ + C CP F GK C+
Sbjct: 1741 WGS-FSCDCPVGFGGKDCQ 1758
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 362 bits (930), Expect = 3e-99
Identities = 281/990 (28%), Positives = 454/990 (45%), Gaps = 113/990 (11%)
Query: 359 SLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG------------- 405
SLKF Y+V L E P G+ ++ + Y ++ E V
Sbjct: 242 SLKFPMPNYQVALFENEPAGTLILQLHA-------HYTIEGEEERVSYYMEGLFDERSRG 294
Query: 406 -FKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQASTVVVIDIVDCNNHAPLFN 459
F++++ TG ++T ++D + + L ++ T P A+T + + + D N+H+P+F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 460 RSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKP 519
+S Y + EN+ G VL + A+DRD N + Y + G F ++ G++ST
Sbjct: 355 QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
Query: 520 MDYELMKRIYTFRVRASDWG-SPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWP 578
+D E Y V A+D G +P ++++++ + NDN P F E N + +D
Sbjct: 415 LDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
Query: 579 VGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSY 636
+ +++ + A D D+ QN + Y I+SGN F L+ SG++ + P L Y
Sbjct: 474 LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP---LDFEDVQKY 530
Query: 637 SLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSD 696
SL I A DG P + +GV+
Sbjct: 531 SLSIKAQDGGR-------------------PPLINSSGVV-------------------- 551
Query: 697 EEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIAD 756
S+ +N P F P VLE+VP+ P+ + A D D+G N +L Y + D
Sbjct: 552 ----SVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVD 606
Query: 757 -------GNEEG----------CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQ 799
G G F I +G +TV A LD E Y V D G+P
Sbjct: 607 TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPP 666
Query: 800 KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL 859
SS +++ V D NDN P F Y+L ++ED VG+++ L +D D+ + T
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG 726
Query: 860 LSPTEKFSLHPLTGELVVT--GHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLED 917
+ +F+L G ++T LD + E +Y+L V A D ++ H ++I + D
Sbjct: 727 GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSH----TAHVLINVTD 781
Query: 918 VNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM 977
N + P + H + V ED P GT + L A+D D G + YV+ D FR+D
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV-PQFRIDPD 840
Query: 978 TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVH 1037
+G + ELD+E + Y L++ A D G P T +E+++LD N+N P F +
Sbjct: 841 SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTT-LEILILDANDN--APQFLWDFY 897
Query: 1038 QGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG-TGLAAFSINQDTGMIQTLAPLD 1096
QG + E++P T ++ V+A D DSG +G L Y + G G F I +G+I+T LD
Sbjct: 898 QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
Query: 1097 REFASYYWLTVLAVDRGS-VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTS 1155
RE + Y L LAVDRGS PLS+ E+ + + D NDN P + ++E+ PVG+
Sbjct: 958 RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSV 1017
Query: 1156 VLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
V ++ A DPD ++ + I G+ FF + + G L +LD E + E++L V+
Sbjct: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL---VV 1074
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFS--HKLFNVRLPERLSPVSPGPVYRLVASDLDE 1273
L S + V + ++D NDNPP+ LFN + + + G + + A D D
Sbjct: 1075 QATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDV 1134
Query: 1274 GLNGRVTYSIEDSDEEAFSIDLVTGVVSSS 1303
+ T+ ++ ++ +D TG + S
Sbjct: 1135 SDSLNYTF-VQGNELRLLLLDPATGELQLS 1163
Score = 348 bits (894), Expect = 5e-95
Identities = 274/936 (29%), Positives = 450/936 (48%), Gaps = 66/936 (7%)
Query: 936 EDLPPGTVLTFLDASDPDLGPAGEVRYVLM----DGAHGTFRVDLMTGALILERELDFER 991
E+ P GT++ L A G V Y + + + G FR+D TGA+ + LD E
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 992 RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV 1051
+ + L + A D P R ++ V+V D N+ H P F ++ +V+EN G +V
Sbjct: 316 KETHVLRVKAVDYSTP-PRSATTYITVLVKDTND--HSPVFEQSEYRERVRENLEVGYEV 372
Query: 1052 IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
+ + A D DS ++ L+Y + G F +N+ +G++ T A LDRE A+ Y L V A D
Sbjct: 373 LTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
Query: 1112 RGSVP--LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
+G P LS+ VYIEV D NDN PQ S+ + + ED + T+VL++ A D D
Sbjct: 432 QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229
+ ++I SGN G F +H ++G+L LD E+ ++ L + D G P L ++S VV
Sbjct: 492 AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
Query: 1230 -VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS-- 1286
V +LDVNDN PIF F + E + P+ PV + A D D G N R+ Y + D+
Sbjct: 552 SVQVLDVNDNEPIFVSSPFQATVLENV-PLG-YPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 1287 ----------DEEAFSIDLVTGVVSSSSTFTA--------GEYNILTIKATDSGQPPLSA 1328
A + D + +SS T E+ ++A D G PP+S+
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 1329 SVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRP--GLFWFNISG 1386
S + I + + F + Y + E V V + R + + ++G
Sbjct: 670 STSVSITVLDVNDNDPV---FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG 726
Query: 1387 GDKDMDFDI--EKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHH 1444
G+ F + ++ G I +A PLD ++ Y L V +DG+R+ V + + + N H
Sbjct: 727 GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHV-LINVTDANTH 785
Query: 1445 RPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSG 1504
RP F + Y V V +D G + + A D+D G++ T + QDP F++DP SG
Sbjct: 786 RPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT-YVIQDP--VPQFRIDPDSG 842
Query: 1505 VLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASV 1564
+ T+ +LD +TLT+M +D IP K + + I + D N + P+F Y+ S+
Sbjct: 843 TMYTMMELDY-ENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
Query: 1565 PDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG-NSEGFFNINALLGIITLAQKLDQANH 1623
+ P T +LQV A D D G N + Y+ G + +G F I G+I ++LD+ N
Sbjct: 902 FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
Query: 1624 APHTLTVKAEDQGSPQWHDLATVI-IHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLV 1682
A + L A D+GSP + I + + + +AP+F K E + + E+ PVGS + +
Sbjct: 962 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
Query: 1683 SAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG 1737
A P E + Y++ EG+ F ++ +G + +LD E Y L ++ ++ A
Sbjct: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS-AP 1080
Query: 1738 AFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPF---VIHASDS-D 1793
+ V + ++D+NDN P+ + + L++ + +N F VI + D
Sbjct: 1081 LVSRATVHILLVDQNDNPPV---------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHD 1131
Query: 1794 KEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMD 1829
+ + L Y ++ L+ +DP+ G L + ++D
Sbjct: 1132 PDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
Score = 335 bits (860), Expect = 4e-91
Identities = 280/997 (28%), Positives = 456/997 (45%), Gaps = 60/997 (6%)
Query: 2690 KFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDT 2746
KF P Y + E+ P G+ I + A + ++ + + G E ++ G F +D T
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSR-GYFRIDSAT 302
Query: 2747 GVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVL 2806
G + +D E+ + + + V A + + + V D ND+ PVFE Y+ +
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 2807 TENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCE 2866
EN+ VG V+ + A D+D+ + + YR+ ++F ++ SG ++T LD E
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVLG----GAWDVFQLNESSGVVSTRAVLDRE 418
Query: 2867 TCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELV 2925
Y V A D G+ LS+ A V + + DENDN P+F+ + Y V E+ V
Sbjct: 419 EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT 2985
++ D D QN + I G+ GQF + + + + LD E KY L +
Sbjct: 479 LRVQATDRD-QGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN--PLDFEDVQKYSLSIK 535
Query: 2986 ASDGK----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTD 3041
A DG +S V + VLDVNDN P + V E+V G+ ++ + A D D+
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 3042 TNAQITYSLH-------GPGA-----------HEFKLDPHTGELTTLTALDRERKDVFNL 3083
NA++ Y L G G+ F++ +G +T LDRE + ++
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
Query: 3084 VAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPD 3141
+A D G S +++ V DVNDN P F + + ++ V + V + ARD D
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 3142 QGANAQVVYSLPD-SAEGHFSIDATTG--VIRLEKPLQVRPQAPLELTVRASDLGTPIPL 3198
AN+ + Y L + F++ + G +I L PL + + L V ASD GT
Sbjct: 716 --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTR--- 769
Query: 3199 STLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSG 3258
S V ++V + PVF ++ ++V V ED P GT + L+ E V
Sbjct: 770 SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 3259 NEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHR 3318
+ +FR+D +G +Y LD+E Y L+I SD TT+ + I D N++
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 3319 PQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGE 3377
PQF D Y + E+A IL VSATD D N + Y+ GG+ G F I P G
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 3378 LQVAKALDREQASSYSLKLRATDSGQP-PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQ 3436
++ + LDRE + Y+L A D G P PL +I + + D+NDN P F + V+
Sbjct: 950 IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
Query: 3437 ENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQE 3495
EN+P+GS V ++ +DPD N ++I +G+ F++ +G L L +
Sbjct: 1010 ENNPVGSVVAKIRANDPDEGPNA-QIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRR 1068
Query: 3496 WYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVG 3551
Y L +QA+ + PL S +V + + +Q+ P +I ++T + F G++G
Sbjct: 1069 EYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG 1125
Query: 3552 KIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRG---HYSFNVTVSDGT 3608
I A D D D+L Y+ + L R + G++ ++ L V+VSDG
Sbjct: 1126 CIPAHDPDVSDSLNYTFVQGNEL-RLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
Query: 3609 FTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVS 3645
+ TA + V + + L ++ + ++ E+ +S
Sbjct: 1185 HSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLS 1221
Score = 323 bits (827), Expect = 3e-87
Identities = 292/959 (30%), Positives = 445/959 (46%), Gaps = 74/959 (7%)
Query: 722 IDVLESVPINTPLARLAATDPDAGFNGKLVYVIA---DGNEEGCFDIELETGLLTVAAPL 778
+ + E+ P T + +L A G ++ Y + D G F I+ TG ++ + L
Sbjct: 252 VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVL 311
Query: 779 DYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTT 838
D E ++L V D TP +S+ +TV VKD ND++P F Y+ + E+ EVG
Sbjct: 312 DRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYE 371
Query: 839 IAELTTKDADSEDNGRVRYTLLSPT-EKFSLHPLTGELVVTGHLDRESEPRYILKVEARD 897
+ + D DS N +RY +L + F L+ +G + LDRE Y L VEA D
Sbjct: 372 VLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
Query: 898 QPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA 957
Q L + + I +ED NDN PQ ++ ++VPED+ T + + A+D D G
Sbjct: 432 QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 958 GEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHV 1016
+ Y ++ G G F + ++G L + LDFE Y+LS+ A DGGRP + V
Sbjct: 492 AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
Query: 1017 EVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY------- 1069
V VLDVN+N P F S Q V EN P G V+ + A D DSG + L Y
Sbjct: 552 SVQVLDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 1070 -FLRAG---------TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSS 1119
FL G T F I+ +G I A LDRE +Y V AVD GS P+SS
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 1120 VTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG 1179
T V I V D NDN P +Q + + EDA VG+SVL L A D D++S +T+ +T G
Sbjct: 670 STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS--VITYQLTGG 727
Query: 1180 NYMGFFMIHPVT--GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVND 1237
N F + GL++ A LD + + +++L VT D + T+ V++ + D N
Sbjct: 728 NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANT 784
Query: 1238 NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVT 1297
+ P+F + V + E PV + L A+D D G N R+TY I+D + F ID +
Sbjct: 785 HRPVFQSSHYTVSVSED-RPVGTS-IATLSANDEDTGENARITYVIQDPVPQ-FRIDPDS 841
Query: 1298 GVVSSSSTFTAGEYN-----ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
G + T +Y LTI A D+G P S + L I + + P F
Sbjct: 842 GTM---YTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI--LILDANDNAP-QFLWD 895
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDK-DMDFDIEKTTGSIVIARP 1407
+Y ++ E P + + +S G G + GGD D DF IE T+G I R
Sbjct: 896 FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
Query: 1408 LDTRRRSNYNL-TVEVTDGSRT-IATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPG 1464
LD + YNL + V GS T ++ V I I +IN + P F + E+ V ++ G
Sbjct: 956 LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
Query: 1465 VELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHT 1522
+ +++A D D+G + ++Y I + FQLD +G L + +LD +
Sbjct: 1016 SVVAKIRANDPDEGPNAQIMYQI---VEGDMRHFFQLDLLNGDLRAMVELDF---EVRRE 1069
Query: 1523 LTVMVRDQEIPIKRNFVWVTIHV--EDGNLHPPRFTQL-----HYEASVPDTIAPGTELL 1575
++V+ P+ T+H+ D N +PP +Y + ++ G +
Sbjct: 1070 YVLVVQATSAPLVSR---ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IG 1125
Query: 1576 QVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAED 1634
+ A D D V+ ++Y+ ++GN ++ G + L++ LD + V D
Sbjct: 1126 CIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 318 bits (815), Expect = 7e-86
Identities = 257/879 (29%), Positives = 409/879 (46%), Gaps = 67/879 (7%)
Query: 1965 SLQFDQDVYWAAVKENLQDRKALVILGAQGNHL----NDTLSYFLLNGTD-----MFHMV 2015
SL+F Y A+ EN + +IL ++ + +SY++ D F +
Sbjct: 242 SLKFPMPNYQVALFEN--EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRID 299
Query: 2016 QSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPY 2075
+ G + T V DRE ++TH L V+ D TP R A + V ++D ND+ P F+ Y
Sbjct: 300 SATGAVSTDSV-LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEY 358
Query: 2076 YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQ 2134
+++ E G + + A+D D N + Y + F+++ G +S + D +
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDRE 418
Query: 2135 ALNKYHLKVIARDGGTPS--LQSEEEVLVTVRNKSN--PLFQSPYYKVRVPENITLYTPI 2190
+Y L V A D G L + V + V ++++ P F Y V+VPE++ L T +
Sbjct: 419 EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 2191 LHTQARSPE---GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATD 2247
L QA + + Y+I+ F +G+L V PLD+E K+ +++A D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 2248 TALGSF--SEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNR 2305
S V V V DVNDN P F + ++ E +P PV+ + A D DSG N
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 2306 DVSYQIVEDGSD--------------VSKF-FQINGSTGEMSTVQELDYEAQQHFHVKVR 2350
+ Y++V+ S F FQI+ S+G ++ ELD E +H+ V
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
Query: 2351 AMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD 2410
A+D G PP++ T V + V D+NDN P F QP YE ++E A G VL +QA D D+
Sbjct: 659 AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA-- 716
Query: 2411 TSRLEYLILSGNQDRHFFINS--SSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVY 2468
S + Y + GN F ++S G+I++ + Y L V ASDG T V
Sbjct: 717 NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVL 776
Query: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528
IN T+AN + P FQ Y ++E+ VGT + L A D+D+G I Y I + + +
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQ 834
Query: 2529 FSINP-NGQIATLQKLDRENSTERVIAIKVMARDGG--GRVAFCTVKIILTDENDNPPQF 2585
F I+P +G + T+ +LD EN + +MA+D G + T++I++ D NDN PQF
Sbjct: 835 FRIDPDSGTMYTMMELDYENQV--AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 2586 KASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKV 2645
Y SI + + ++QV A D D G N + Y+ D I P +GV++
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
Query: 2646 KDSLVGLENQTLDFFIKAQD-GGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDL 2704
+ L + + A D G P ++ V +++ ++ + P F + E+
Sbjct: 953 QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
Query: 2705 PEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDH 2757
P GS +V + A DP ++Y +V G + F LD G ++ +D
Sbjct: 1013 PVGS---VVAKIRANDPDEGPNAQIMYQIVEG-----DMRHFFQLDLLNGDLRAMVELDF 1064
Query: 2758 ESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPV 2796
E + Y + V A + +VS +V+I + D NDN PV
Sbjct: 1065 EVRREYVLVVQA---TSAPLVSRATVHILLVDQNDNPPV 1100
Score = 296 bits (758), Expect = 3e-79
Identities = 270/979 (27%), Positives = 435/979 (44%), Gaps = 74/979 (7%)
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRA---GTGLAAFSINQDTGMIQTLA 1093
+Q + EN P+GT ++ + A G + + Y++ F I+ TG + T +
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG 1153
LDRE + L V AVD + P S+ T + + V D ND+ P Q+ + ++E+ VG
Sbjct: 310 VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVG 369
Query: 1154 TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVT 1213
VL + A D DS L + + G + F ++ +G++ST LDRE E+ L V
Sbjct: 370 YEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
Query: 1214 VLDNGEPS--LKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDL 1271
D G L +T+ V + + D NDN P FS + + V++PE + + V R+ A+D
Sbjct: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA--VLRVQATDR 486
Query: 1272 DEGLNGRVTYSIEDSDEEA-FSIDLVTGV--VSSSSTFTAGEYNILTIKATDSGQPPL-- 1326
D+G N + YSI + F + ++G+ V + F + L+IKA D G+PPL
Sbjct: 487 DQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLIN 546
Query: 1327 -SASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNI- 1384
S V + + + P + F T V PV H+ V + G + +
Sbjct: 547 SSGVVSVQVLDVNDNEPIFVSSPFQATVLE-NVPLGYPVVHIQAVDADSGENARLHYRLV 605
Query: 1385 ----------SGGDK------DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSR 1427
S G K D F I ++G I + LD +Y+ VE D GS
Sbjct: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
Query: 1428 TIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIH 1486
+++ + + + ++N + P F + YE+R+ +D G +L +QA D+D + Y +
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLT 725
Query: 1487 GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE 1546
G +L G++ LD Q+ L V D + + V I+V
Sbjct: 726 GGNTRNRFALSS-QRGGGLITLALPLDYKQ-EQQYVLAVTASDGT---RSHTAHVLINVT 780
Query: 1547 DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNIN 1606
D N H P F HY SV + GT + + A D D G NA + Y + + F I+
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRID 838
Query: 1607 ALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYF 1666
G + +LD N +TLT+ A+D G PQ D T+ I + ++ +AP F Y
Sbjct: 839 PDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898
Query: 1667 VEIPESIPVGSPILLVSAMSPSE-----VTYELREGNK-DGVFSMNSYSGLISTQKKLDH 1720
I E P + IL VSA + Y + G+ DG F + SG+I TQ++LD
Sbjct: 899 GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDR 958
Query: 1721 EKISSYQL---KIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMI 1777
E ++ Y L + + V + V I+D NDNAPMF K + E P+ S++
Sbjct: 959 ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV 1018
Query: 1778 MDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A+D D+ N+ ++Y+I+E + FF++D G L + E+D+E +
Sbjct: 1019 AK-------IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
Query: 1838 FCVYVHDQGSPVLFAPRPAQVIIHVR--DVNDSPPRFSE-QIY---EVAIVGPIHPGMEL 1891
V AP ++ +H+ D ND+PP + QI V P +
Sbjct: 1072 LVVQATS-------APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVI 1124
Query: 1892 LMVRASDED--SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG--LSRKLTIRASDGL 1947
+ A D D +NY+ GN + + P TG + + L + + SDG+
Sbjct: 1125 GCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
Query: 1948 YQDTALVKISLTQVLDKSL 1966
+ TA + +T + D L
Sbjct: 1185 HSVTAFCTLRVTIITDDML 1203
Score = 286 bits (733), Expect = 2e-76
Identities = 255/969 (26%), Positives = 416/969 (42%), Gaps = 82/969 (8%)
Query: 1554 RFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHY---SLLKGNSEGFFNINALLG 1610
+F +Y+ ++ + GT +LQ+ A G V Y L S G+F I++ G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 1611 IITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIP 1670
++ LD+ H L VKA D +P + + V ++ +P+F +SEY +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 1671 ESIPVGSPILLVSAMS-PSEVTYELRE---GNKDGVFSMNSYSGLISTQKKLDHEKISSY 1726
E++ VG +L + A S + LR G VF +N SG++ST+ LD E+ + Y
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
Query: 1727 QLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNN 1782
QL + +G N V +++ DENDN P F + +V Q+ E L + ++
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR--- 480
Query: 1783 NPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYV 1842
+ A+D D+ N+ + Y IL F + G L +++ +D+E + + +
Sbjct: 481 ----VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
Query: 1843 HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSE 1902
D G P L V + V DVND+ P F ++ ++ + G ++ ++A D DS
Sbjct: 537 QDGGRPPLI-NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 1903 VNYSIKTGNADEAVT---------------------IHPVTGSISVLNPAFLGLSRKLTI 1941
N + D A T IH +G I+V L R+
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC----AELDREEVE 651
Query: 1942 RASDGL---------YQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA 1992
S G+ + V I++ V D F Q Y + E+ +++ L A
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
Query: 1993 QGNHLNDTLSYFLLNGTDMFHMV---QSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
+ N ++Y L G Q G L T + D +Q+ + LAV D T
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRS 770
Query: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
A L+ V+ D N + P F+ Y + + G + +SA DED G N +TY
Sbjct: 771 HTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI 828
Query: 2110 AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP--SLQSEEEVLVTVRNKS 2167
+ FRIDP G + DY+ Y L ++A+D G P S + E+L+ N +
Sbjct: 829 QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
Query: 2168 NPLFQSPYYKVRVPENITLYTPILHTQA----RSPEGLRLIYNIV-EEEPLMLFTTDFKT 2222
P F +Y+ + E+ T IL A P G RL+Y ++ F + +
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG-RLLYTFQGGDDGDGDFYIEPTS 947
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVE--DVNDNPPTFSQLVYTTS 2280
GV+ LD E+ + A D + A+VE+ V D+NDN P F +
Sbjct: 948 GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE 2340
+ E P + V ++ A+D D G N + YQIVE D+ FFQ++ G++ + ELD+E
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE--GDMRHFFQLDLLNGDLRAMVELDFE 1065
Query: 2341 AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ-----YEANVSELATCG 2395
++ + + V+A PL V + + D NDNPP Q Y N S G
Sbjct: 1066 VRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVG 2455
++ + A DPD D+ L Y + GN+ R ++ ++G + + + + V
Sbjct: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
Query: 2456 ASDGVFRAT 2464
SDG+ T
Sbjct: 1180 VSDGIHSVT 1188
Score = 279 bits (714), Expect = 4e-74
Identities = 264/1044 (25%), Positives = 471/1044 (45%), Gaps = 88/1044 (8%)
Query: 819 RFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTG 873
+FP YQ+ + E+ GT I +L + RV Y + ++ F + TG
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 874 ELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLK 933
+ LDRE++ ++L+V+A D + + T + + ++D ND+SP R +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRS--ATTYITVLVKDTNDHSPVFEQSEYRER 361
Query: 934 VPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRA 993
V E+L G + + ASD D +RY ++ GA F+++ +G + LD E A
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAA 421
Query: 994 GYNLSLWASDGGR---PLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQ 1050
Y L + A+D GR PL+ ++EV +EN + P F+ + QV E+ T
Sbjct: 422 EYQLLVEANDQGRNPGPLSATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTA 477
Query: 1051 VIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV 1110
V+ V A D D G + + Y + +G F ++ +G++ + PLD E Y L++ A
Sbjct: 478 VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
Query: 1111 DRGSVPL-SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
D G PL +S V ++V D NDN P + F ++ E+ P+G V+ + A D DS
Sbjct: 538 DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 1170 GKLTFNI--TSGNYMGF---------------FMIHPVTGLLSTAQQLDRENKDEHILEV 1212
+L + + T+ ++G F IH +G ++ +LDRE + + V
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
Query: 1213 TVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272
+D+G P + S++ V + +LDVNDN P+F+ + +RL E + S V L A D D
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS--SVLTLQARDRD 715
Query: 1273 EGLNGRVTYSIEDSD-EEAFSIDLVTG----VVSSSSTFTAGEYNILTIKATDSGQPPLS 1327
N +TY + + F++ G ++ + + +L + A+D G +
Sbjct: 716 --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHT 772
Query: 1328 ASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRPGLFWFN 1383
A V +++ RP F ++Y+ +V E PV + +S G +
Sbjct: 773 AHVLINVTDANTHRP-----VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
Query: 1384 ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVHIFMIAN 1440
I D F I+ +G++ LD + Y LT+ D ++ T + I +I +
Sbjct: 828 IQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI-LILD 884
Query: 1441 INHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQ 1498
N + PQFL Y+ + +D P +L+V A D+D G + L+YT G D F
Sbjct: 885 ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD--FY 942
Query: 1499 LDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRN-FVWVTIHVEDGNLHPPRFTQ 1557
++P+SGV+ T +LD + + L + D+ P + V + + + D N + P F +
Sbjct: 943 IEPTSGVIRTQRRLD-RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEK 1001
Query: 1558 LHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQK 1617
E V + G+ + ++RA D D G NA++ Y +++G+ FF ++ L G + +
Sbjct: 1002 DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVE 1061
Query: 1618 LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSK-----SEYFVEIPES 1672
LD + L V+A S ATV I + + + P+ + Y S
Sbjct: 1062 LDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNS 1118
Query: 1673 IPVGSPILLVSAMSP---SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLK 1729
P G I + A P + Y +GN+ + ++ +G + + LD+ + ++
Sbjct: 1119 FPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
Query: 1730 IR---GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMD------- 1779
+ G + AF + V + I D+ + ++ + Q +PL ++ ++
Sbjct: 1178 VSVSDGIHSVTAFCTLRVTI-ITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLS 1236
Query: 1780 -KNNNPFVIHA-SDSDKEANSLLV 1801
++ FV + +D+D +N L V
Sbjct: 1237 TTKDDVFVFNVQNDTDVSSNILNV 1260
Score = 276 bits (707), Expect = 2e-73
Identities = 244/912 (26%), Positives = 415/912 (45%), Gaps = 72/912 (7%)
Query: 1791 DSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL 1850
+ ++E S + + + + +F+ID + G ++ S +D E+ + V D +P
Sbjct: 274 EGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTP-- 331
Query: 1851 FAPRPAQ--VIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK 1908
PR A + + V+D ND P F + Y + + G E+L +RASD DS +N +++
Sbjct: 332 --PRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLR 389
Query: 1909 ---TGNADEAVTIHPVTGSIS--VLNPAFLGLSRKLTIRASD-----GLYQDTALVKISL 1958
G A + ++ +G +S + +L + A+D G TA V I +
Sbjct: 390 YRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV 449
Query: 1959 TQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNG--TDMFHM 2014
D QF + Y V E++ A++ + A + N + Y +L+G F++
Sbjct: 450 EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYL 509
Query: 2015 VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRV-AQGLVRVSIEDVNDNPPKFKHL 2073
+G+L D E + L+++ +D P + + G+V V + DVNDN P F
Sbjct: 510 HSLSGILDVIN-PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS 568
Query: 2074 PYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY------------------ 2115
P+ + + G + + A D D G N + Y + +
Sbjct: 569 PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDF 628
Query: 2116 -FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQ 2172
F+I G I++ D + + Y V A D G+P + S V +TV N ++P+F
Sbjct: 629 PFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Query: 2173 SPYYKVRVPENITLYTPILHTQARSPEGLRLI-YNIVEEEPLMLFTTDFKT--GVLTVTG 2229
P Y++R+ E+ + + +L QAR + +I Y + F + G++T+
Sbjct: 689 QPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLAL 748
Query: 2230 PLDYESKTKHVFTVRATDTALGSFSE-ATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288
PLDY+ + ++V V A+D G+ S A V + V D N + P F YT S+SE P
Sbjct: 749 PLDYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
Query: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348
T + L A+D+D+G N ++Y I D F+I+ +G M T+ ELDYE Q + +
Sbjct: 806 TSIATLSANDEDTGENARITYVI----QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLT 861
Query: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408
+ A D G P + T + + + D NDN P+F Y+ ++ E A +L+V A D DS
Sbjct: 862 IMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
Query: 2409 RDTSRLEYLILSGNQ-DRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD----GVFRA 2463
RL Y G+ D F+I +SG+I + + YNL A D A
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINK 2523
+V + + + N +P F++ E + EN VG+ V + A D D GP I Y I+
Sbjct: 982 SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
Query: 2524 LASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNP 2582
F ++ NG + + +LD E E V+ ++ + V+ TV I+L D+NDNP
Sbjct: 1042 DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS---APLVSRATVHILLVDQNDNP 1098
Query: 2583 P-----QFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEIN 2637
P Q + Y V+ +SN + + A+D D + + T+ E ++ ++
Sbjct: 1099 PVLPDFQILFNNY-VTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE---LRLLLLD 1154
Query: 2638 PVTGVVKVKDSL 2649
P TG +++ L
Sbjct: 1155 PATGELQLSRDL 1166
Score = 265 bits (678), Expect = 6e-70
Identities = 268/997 (26%), Positives = 425/997 (42%), Gaps = 122/997 (12%)
Query: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYY----AFNTRSE-MFAIHPTSGV 202
F P+Y+V + E+ P + I ++ A G+ Y F+ RS F I +G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVT 262
V+ L+ + H L+V AVD + + LV P S
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTND--HSPVFEQSEYRE 360
Query: 263 PPDSNDGTTYATVLVDANSSGAEVES---VEVVGGDPGKHFKAIKSYARSNEFSLVSVKD 319
N Y + + A+ + + + V+GG A + + +VS +
Sbjct: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-------AWDVFQLNESSGVVSTRA 413
Query: 320 INWMEYLHGFNLSLQARS---GSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSP 376
+ E + L ++A GP + + + +F + Y VQ+ E
Sbjct: 414 VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
Query: 377 PGSRVVMVRVTPAFPNLQYVLKPS--SENVG--FKLNARTGLITTTKLMDFHDRAHYQLH 432
+ V+ V+ T + S S NV F L++ +G++ +DF D Y L
Sbjct: 474 LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 433 IRTSPG------QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486
I+ G +S VV + ++D N++ P+F S + T+ EN+P G V+ + A D D
Sbjct: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
Query: 487 HGENGYVTYSI------------AGPKA------LPFSIDPYLGIISTSKPMDYELMKRI 528
GEN + Y + AGPK PF I G I+ +D E ++
Sbjct: 594 SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH- 652
Query: 529 YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588
Y+F V A D GSP S+ + + ++NDN P+F + + +D VG S++T+ A
Sbjct: 653 YSFGVEAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
Query: 589 IDVDELQNLKYEIVSGNELEYFDLN--HFSGVISLKRPFINLTAGQPTSYSLKITASDG- 645
D D + Y++ GN F L+ G+I+L P L Q Y L +TASDG
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALP---LDYKQEQQYVLAVTASDGT 768
Query: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
+++ + +N+T D + PV +
Sbjct: 769 RSHTAHVLINVT---DANTHRPV------------------------------------F 789
Query: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
Q +HYT + V E P+ T +A L+A D D G N ++ YVI D + F I
Sbjct: 790 QSSHYT----------VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRI 837
Query: 766 ELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825
+ ++G + LDYE Y L + D G PQKS L + + D NDNAP+F Y
Sbjct: 838 DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFY 897
Query: 826 QLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLD 882
Q +I ED T+I +++ D DS NGR+ YT + F + P +G + LD
Sbjct: 898 QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
Query: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942
RE+ Y L A D+ S L + ++ +T+ D+NDN+P + L V E+ P G+
Sbjct: 958 RENVAVYNLWALAVDRGSP-TPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGS 1016
Query: 943 VLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001
V+ + A+DPD GP ++ Y +++G F++DL+ G L ELDFE R Y L + A
Sbjct: 1017 VVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA 1076
Query: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF--VHQGQVQENSPSGTQVIVVAAQDD 1059
+ PL R H ++++D N+N PP F + V S S ++
Sbjct: 1077 TSA--PLVSRATVH--ILLVDQNDN--PPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAH 1130
Query: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLD 1096
D + L Y G L ++ TG +Q LD
Sbjct: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
Score = 253 bits (646), Expect = 3e-66
Identities = 245/931 (26%), Positives = 411/931 (44%), Gaps = 76/931 (8%)
Query: 1273 EGLNGRVTYSIEDSDEEA----FSIDLVTGVVSSSSTFT--AGEYNILTIKATDSGQPPL 1326
EG RV+Y +E +E F ID TG VS+ S E ++L +KA D PP
Sbjct: 274 EGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR 333
Query: 1327 SASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNIS- 1385
SA+ + + S + F+++ Y V E V + V I R N+
Sbjct: 334 SATTYITVLVKDTNDHSPV---FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRY 390
Query: 1386 ---GGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT----IATQVHIFMI 1438
GG D+ F + +++G + LD + Y L VE D R AT +
Sbjct: 391 RVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV 449
Query: 1439 ANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGS-ASLF 1497
+ N + PQF E Y V+VP+D +LRVQA D+D+G++ IH S G+ A F
Sbjct: 450 EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNA--AIHYSILSGNVAGQF 507
Query: 1498 QLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ-EIPIKRNFVWVTIHVEDGNLHPPRFT 1556
L SG+L + LD +++L++ +D P+ + V++ V D N + P F
Sbjct: 508 YLHSLSGILDVINPLDF-EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
Query: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL-------LKGNSEGF------- 1602
++A+V + + G ++ ++A+DAD G NA +HY L L G S G
Sbjct: 567 SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTP 626
Query: 1603 ---FNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPI 1659
F I+ G IT+ +LD+ ++ V+A D GSP +V I V + + P+
Sbjct: 627 DFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
Query: 1660 FSKSEYFVEIPESIPVGSPILLVSAM---SPSEVTYELREGNKDGVFSMNSY--SGLIST 1714
F++ Y + + E VGS +L + A + S +TY+L GN F+++S GLI+
Sbjct: 687 FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL 746
Query: 1715 QKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY 1774
LD+++ Y L + S+ + T V++++ D N + P+F S + +SE P+
Sbjct: 747 ALPLDYKQEQQYVLAVTASDGTRSHT-AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
Query: 1775 SMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMP 1834
+ I + A+D D N+ + Y I +P + F+IDP GT+ + E+DYE+
Sbjct: 806 TSIA-------TLSANDEDTGENARITYVIQDP--VPQFRIDPDSGTMYTMMELDYENQV 856
Query: 1835 SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMV 1894
++ + D G P +++I D ND+ P+F Y+ +I P +L V
Sbjct: 857 AYTLTIMAQDNGIPQKSDTTTLEILI--LDANDNAPQFLWDFYQGSIFEDAPPSTSILQV 914
Query: 1895 RASDEDSEVN----YSIKTGN-ADEAVTIHPVTGSISVL------NPAFLGLSRKLTIRA 1943
A+D DS N Y+ + G+ D I P +G I N A L R
Sbjct: 915 SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRG 974
Query: 1944 SDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG--NHLNDTL 2001
S + +++++ + D + F++D V+EN + + A N +
Sbjct: 975 SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQI 1034
Query: 2002 SYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIE 2061
Y ++ G DM H Q + + + + E + V+ P V++ V + +
Sbjct: 1035 MYQIVEG-DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLV 1092
Query: 2062 DVNDNPPKFKHLPY----YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFR 2117
D NDNPP Y + + P V+ + A D D+ + T+ +
Sbjct: 1093 DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLL 1152
Query: 2118 IDPYLGDISLKKPFDYQALNKYHLKVIARDG 2148
+DP G++ L + D + ++V DG
Sbjct: 1153 LDPATGELQLSRDLDNNRPLEALMEVSVSDG 1183
Score = 221 bits (564), Expect = 9e-57
Identities = 240/973 (24%), Positives = 406/973 (41%), Gaps = 121/973 (12%)
Query: 102 SNTALLNREVRDSYTLIIQATE-KTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160
S ++L+RE ++++ L ++A + T A T + V + D ND P+F YR + E+
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 161 MPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHEL 219
+ + + + A+D D NA Y ++F ++ +SGVV+ L+ +++L
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQL 425
Query: 220 QVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIAS---VVVTPPDSNDGTTYATVL 276
V A D+ R + A + + VE P + VV P D T V
Sbjct: 426 LVEANDQGR---NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
Query: 277 VDANSSGAEVE-SVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQA 335
G ++ G+ F Y S L + +++ E + ++LS++A
Sbjct: 483 ATDRDQGQNAAIHYSILSGNVAGQF-----YLHSLSGILDVINPLDF-EDVQKYSLSIKA 536
Query: 336 RSGSGPYFY--SQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA---- 389
+ G P S + + + F + ++ + E P G VV ++ A
Sbjct: 537 QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 390 FPNLQYVLKPSSE-----------------NVGFKLNARTGLITTTKLMDFHDRAHYQLH 432
L Y L ++ + F+++ +G IT +D + HY
Sbjct: 597 NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
Query: 433 IR-----TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH 487
+ + P +ST V I ++D N++ P+F + +Y+ L+E+ G+SVL + A DRD
Sbjct: 657 VEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
Query: 488 GENGYVTYSIAGPKA---LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRR 544
N +TY + G S G+I+ + P+DY+ ++ Y V ASD R
Sbjct: 716 -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK-QEQQYVLAVTASDG----TR 769
Query: 545 EKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSG 604
+ + + + N ++P+F+ + T S+ +D PVG SI T+SA D D +N + V
Sbjct: 770 SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 605 NELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNYASPTTLNITVVKDP 662
+ + F ++ SG + + L +Y+L I A D + TTL I ++
Sbjct: 830 DPVPQFRIDPDSGTM---YTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILIL--- 883
Query: 663 HFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSI 722
N PQF F Q
Sbjct: 884 -------------------------------------------DANDNAPQFLWDFYQG- 899
Query: 723 DVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLDYE 781
+ E P +T + +++ATD D+G NG+L+Y G++ +G F IE +G++ LD E
Sbjct: 900 SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRE 959
Query: 782 ATNFYILNVTVYDLGTPQKSSWKL-LTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA 840
Y L D G+P S + + V + D NDNAP F +L + E+ VG+ +A
Sbjct: 960 NVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVA 1019
Query: 841 ELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLDRESEPRYILKVEARDQ 898
++ D D N ++ Y ++ + F L L G+L LD E Y+L V+A
Sbjct: 1020 KIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA 1079
Query: 899 PSKGHQLFSVTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDL 954
P L S + I L D NDN P I +N + + P V+ + A DPD+
Sbjct: 1080 P-----LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDV 1134
Query: 955 GPAGEVRYVLMDGAH-GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTL 1013
+ + Y + G +D TG L L R+LD R + + SDG +
Sbjct: 1135 --SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCT 1192
Query: 1014 CHVEVIVLDVNEN 1026
V +I D+ N
Sbjct: 1193 LRVTIITDDMLTN 1205
Score = 209 bits (532), Expect = 5e-53
Identities = 232/869 (26%), Positives = 363/869 (41%), Gaps = 114/869 (13%)
Query: 69 VRYRIISG--DVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTL 126
+RYR++ G DV + ++ V S A+L+RE Y L+++A ++
Sbjct: 388 LRYRVLGGAWDVFQLNESSGVV-------------STRAVLDREEAAEYQLLVEANDQGR 434
Query: 127 E---LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEF 183
L A V + + D+ND P FS +Y V + ED+ L + + +V ATD D GQNA
Sbjct: 435 NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAI 494
Query: 184 YYAF--NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMR-KISEGNGFGSLA 240
+Y+ + F +H SG++ V L+ K+ L + A D R + +G S+
Sbjct: 495 HYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQ 554
Query: 241 ALVVH-VEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSG------AEVESVEVVG 293
L V+ EP P A+V+ P V D+ + + S + G
Sbjct: 555 VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGG 614
Query: 294 GDPGKHFKAIKSYARSNEFSLVSVKDINWM--------EYLHGFNLSLQA-RSGSGPYFY 344
G G K+ A + +F W+ E + ++ ++A GS P
Sbjct: 615 GSAGP-----KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 345 SQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN--LQYVLKPSSE 402
S + + F + Y ++L+E + GS V+ ++ N + Y L +
Sbjct: 670 STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNT 729
Query: 403 NVGFKLNART--GLITTTKLMDFHDRAHYQLHIRTSPGQASTV--VVIDIVDCNNHAPLF 458
F L+++ GLIT +D+ Y L + S G S V+I++ D N H P+F
Sbjct: 730 RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVF 789
Query: 459 NRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSK 518
S Y ++ E+ P GTS+ ++A D D GEN +TY I P F IDP G + T
Sbjct: 790 QSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP-VPQFRIDPDSGTMYTMM 848
Query: 519 PMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWP 578
+DYE + YT + A D G P ++ ++ + + + NDN P F GSI +D P
Sbjct: 849 ELDYE-NQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP 906
Query: 579 VGKSIMTMSAIDVDELQN--LKYEIVSGNELE-YFDLNHFSGVISLKRPFINLTAGQPTS 635
SI+ +SA D D N L Y G++ + F + SGVI +R L
Sbjct: 907 PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR---RLDRENVAV 963
Query: 636 YSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESS 695
Y+L A D SPT L+ +V E+ VT
Sbjct: 964 YNLWALAVD---RGSPTPLSASV------EIQVT-------------------------- 988
Query: 696 DEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA 755
IN P FE + V E+ P+ + +A++ A DPD G N +++Y I
Sbjct: 989 --------ILDINDNAPMFEKD-ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
Query: 756 DGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWND 815
+G+ F ++L G L LD+E Y+L V +++ +L V D ND
Sbjct: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLV---DQND 1096
Query: 816 NAPRFPP-----GGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE--KFSL 868
N P P Y S G I + D D D+ + YT + E L
Sbjct: 1097 NPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLL 1153
Query: 869 HPLTGELVVTGHLDRESEPRYILKVEARD 897
P TGEL ++ LD +++V D
Sbjct: 1154 DPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 157 bits (397), Expect = 2e-37
Identities = 191/766 (24%), Positives = 320/766 (41%), Gaps = 115/766 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATE--KT 125
A+ Y I+SG+VA F Y+ L + L+ E Y+L I+A + +
Sbjct: 493 AIHYSILSGNVAGQF----YLHSLSGILDVINP------LDFEDVQKYSLSIKAQDGGRP 542
Query: 126 LELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYY 185
+ + V V +LD ND +P+F ++ T+ E++PL P+ + A DAD G+NA +Y
Sbjct: 543 PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
Query: 186 AF-NTRSEM------------------FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR 226
+T S F IH +SG +TV +L+ + V AVD
Sbjct: 603 RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
Query: 227 MRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLV---DANSSG 283
+ S+ L V+ + P + D+ G++ T+ DANS
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANS-- 718
Query: 284 AEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYF 343
V + ++ GG+ F A+ S +L D + + L++ A G+ +
Sbjct: 719 --VITYQLTGGNTRNRF-ALSSQRGGGLITLALPLDYKQEQQ---YVLAVTASDGTRSHT 772
Query: 344 YSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRV----TPAFPNLQYVLKP 399
+ ++ + F+ + Y V +SE P G+ + + T + YV++
Sbjct: 773 AHVL--INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD 830
Query: 400 SSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNH 454
F+++ +G + T +D+ ++ Y L I +T + I I+D N++
Sbjct: 831 PVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
Query: 455 APLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLG 512
AP F Y G++ E+ PP TS+L V+ATDRD G NG + Y+ G F I+P G
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
Query: 513 IISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGS 572
+I T + +D E + +Y A D GSP V I + + ++NDN PMFE+
Sbjct: 949 VIRTQRRLDRENV-AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 573 IRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTA 630
+ ++ PVG + + A D DE N + Y+IV G+ +F L+ +G + R + L
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDL---RAMVELDF 1064
Query: 631 GQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQ 690
Y L + A+ S T++I +V D + PV
Sbjct: 1065 EVRREYVLVVQATSAP-LVSRATVHILLV-DQNDNPPV---------------------- 1100
Query: 691 NQESSDEEFTSLSTYQI--NHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNG 748
L +QI N+Y + FP + + + A DPD +
Sbjct: 1101 -----------LPDFQILFNNYVTNKSNSFPTGV-----------IGCIPAHDPDV--SD 1136
Query: 749 KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
L Y GNE ++ TG L ++ LD ++ V+V D
Sbjct: 1137 SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 59.7 bits (143), Expect = 6e-08
Identities = 26/67 (38%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 3969 GYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG- 4027
G C+CPP F+G +CE + C PC G C G +C C +TG+ CE++AR
Sbjct: 1346 GLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSG 1405
Query: 4028 -CSEGHC 4033
C+ G C
Sbjct: 1406 RCANGVC 1412
Score = 55.8 bits (133), Expect = 9e-07
Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 31/227 (13%)
Query: 3795 HIHFYLKTLQPQAILLFT--NETASVSLKLASGVPQLEYHCLGGFYGNLSSQRHV----- 3847
H L+ + Q L F+ T +V+ K+ SGV +H + Y N + H+
Sbjct: 1489 HDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHG 1548
Query: 3848 -NDHEWHSILVEEMDASIRLMVDS-MGNTSLVVPENCRGLRPERHL----LLGGLILLHS 3901
+ + + V++ D ++ + +GN S G + L LLGG+ L
Sbjct: 1549 PSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPE 1608
Query: 3902 SSNV-SQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQ-CCLHSDYCSQNTCLNG 3959
V ++ F GC+ + V+ + +D+ AG + + C ++C C NG
Sbjct: 1609 DFPVHNRQFVGCMRNLSVDGKNVDM-------AGFIANNGTREGCAARRNFCDGRRCQNG 1661
Query: 3960 GKC--SWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILS 4004
G C W Y+C+CP +F GK+CEQ + P L G ++S
Sbjct: 1662 GTCVNRWNM---YLCECPLRFGGKNCEQAMPH----PQLFSGESVVS 1701
Score = 55.1 bits (131), Expect = 2e-06
Identities = 67/290 (23%), Positives = 111/290 (38%), Gaps = 43/290 (14%)
Query: 3778 FSGQSYVRY---RAPAARNWHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCL 3834
FSG+S V + + W++ +T + ++L+ S +L L++
Sbjct: 1694 FSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVS 1753
Query: 3835 GG---FYGNLSSQRHVNDHEWHSILVE--------EMDASIRLMVD-SMGNTSLVVPENC 3882
G + S V D EWH +L+E EM + + +D M +
Sbjct: 1754 HGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGML 1813
Query: 3883 RGLRPERHLLLGGLILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALT 3942
GL R +++GG +V +GF GC+ V + ++ A L+ +
Sbjct: 1814 PGL-TVRSVVVGG--ASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNA--LKVRVKD 1868
Query: 3943 QCCLHSDYCSQNTCLNGGKC--SWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGT 4000
C + D C+ + C +C +W Y C C + G +C + C PC G
Sbjct: 1869 GCDV-DDPCTSSPCPPNSRCHDAW---EDYSCVCDKGYLGINCV---DACHLNPCENMGA 1921
Query: 4001 CIL---SPKGASCNCPHPYTGDRCEME-----ARG------CSEGHCLVT 4036
C+ SP+G C C + G CE + RG C HC V+
Sbjct: 1922 CVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVS 1971
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 270 bits (689), Expect = 3e-71
Identities = 299/1119 (26%), Positives = 486/1119 (43%), Gaps = 104/1119 (9%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 2522 NKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDN 2581
NP+ Q L+ +T + + V+ D G + F ++ +
Sbjct: 192 --------QYNPDDPDRA-QNLNERRTTTTTLTVDVLDGDDLGPM-FLPCVLVPNTRDCR 241
Query: 2582 PPQFKAS--EYTVSIQSNVSKDSPVIQVLAYDADEGQNAD---VTYSV---NPEDLVKDV 2633
P ++A+ E + N +P IQ + D + +D + YS+ PED +
Sbjct: 242 PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR-F 300
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDGGPPHWNSLVPVRLQVVPKKVSLPKFS 2692
++P T + + + + +Q D IKA QD G P + + ++++ + P F+
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFT 359
Query: 2693 EPLYTFSAPEDLPEGSEIGI-------VKAVA-------AQDPVIYSLVRGTTPESNKDG 2738
P Y E P G+ I ++ VA +DP ++ + T
Sbjct: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT------S 413
Query: 2739 VFSLDPDTGVIK---VRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRP 2795
VF++ TG+ + + +P+D E + Y + A V VNIQV D NDN P
Sbjct: 414 VFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQESEPVIVNIQVMDANDNTP 470
Query: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
F Y + +M G SVIQ+TA+D D G +G+++Y + + F I+ +G
Sbjct: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FIINKTTG 526
Query: 2856 WITTLQELDCETCQTYHFHVVAYDHGQTIQ-LSSQALVQVSITDENDNA-PRFASEEYRG 2913
IT ++ +TY V A D+ + +S V + + N+ + PRF Y
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
+ E G ++ L+ D + +T I GDP F +S+ ++ K LD
Sbjct: 587 EISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSET--TGILTLGKALD 640
Query: 2974 REHTAKYLLRVTASDGK--FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
RE T +Y+L +TASDG+ ++ TV I V DVNDN+P L + F+
Sbjct: 641 RESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 700
Query: 3032 KVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
+V ATD D N Q+ YSL G + F++ + G + T L+RE +D + LV ATDG
Sbjct: 701 QVKATDPDAGINGQVHYSL-GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGA 758
Query: 3092 GRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV 3149
+ +TL ++ D++DN+P F S V V +N T + + A+D D GAN
Sbjct: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 818
Query: 3150 YSLPDSAEGHFSIDATTGVIRLEKPLQVR----PQAPLELTVRASDLGTPIPLSTLGTVT 3205
P+ + F++ TG + L + L +A + V A D+ +P + TVT
Sbjct: 819 IRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVT 876
Query: 3206 VSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV--LQLATLTRPG--AEKTGYRVVSGN-- 3259
V V + DY PVF + V DA GT + + PG A + YRV
Sbjct: 877 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
Query: 3260 -EQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHR 3318
F ++ +G + +L+ E + + L + +S TV + + E
Sbjct: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-I 995
Query: 3319 PQFPQDPY-STRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGE 3377
P+F Q+ Y V E A G ++ +SA +N I YS++ GN+ F I+ G
Sbjct: 996 PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGV 1051
Query: 3378 LQVAKALDREQASSYSLKLRA-------TDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ V LD E +SY L+++A + P + I++ D N++PP F +
Sbjct: 1052 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1111
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR-----ITKGNNGSAFRVTPDGWLVT 3485
Y V E++ + + VL++ +D D+ N ++R I +G G T G + T
Sbjct: 1112 YIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAYRLIIPPIKEGKEGFVVE-TYTGLIKT 1169
Query: 3486 AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQ 3524
A + +++ Q+ A+D LS V V V Q
Sbjct: 1170 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1208
Score = 254 bits (649), Expect = 1e-66
Identities = 301/1200 (25%), Positives = 498/1200 (41%), Gaps = 164/1200 (13%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVL 222
ATD D G N + Y R++ T+ L+ G L +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 232
Query: 223 AVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-- 280
V R + AA+ P LR P + ++VTPP + D N
Sbjct: 233 LVPNTR---DCRPLTYQAAI-----PELRTPEELNPIIVTPP-------IQAIDQDRNIQ 277
Query: 281 -SSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGS 339
S ++ G P + + + R+ E SL+ + +N ++ F+L ++A +
Sbjct: 278 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL--EPVN-RDFHQKFDLVIKAEQDN 334
Query: 340 GPYFYSQIRGFHLP--PSKLSSLKFEKAVYRVQLSEFSPPGSRVV-------MVRVTPAF 390
G + G H+ S F Y+ + E +P G+ + +R+
Sbjct: 335 G-HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL-----------MDFHDRAHYQLHIRTSPGQ 439
+++ P + LN T + T T+ +D ++ Y I G
Sbjct: 394 KDIEDTKDPE---LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 450
Query: 440 AST---VVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYS 496
+ +V I ++D N++ P F SYD + ++ PG SV+ +TA D D G NG +TY
Sbjct: 451 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 510
Query: 497 IAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEV-SIFLQ-L 554
I F I+ G+I+ + ++ ++ R Y V+A+D P R + +++++ L
Sbjct: 511 ILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
Query: 555 RNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNH 614
N + P F ++ + I + VG ++ + A D E ++ Y I +G+ F+L+
Sbjct: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVFNLSE 628
Query: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGK-NYASPTTLNITVVKDPHFEVPVTCDKT 673
+G+++L + L Y L ITASDG+ + S T+NI V
Sbjct: 629 TTGILTLGKA---LDRESTDRYILIITASDGRPDGTSTATVNIVVT-------------- 671
Query: 674 GVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTP 733
+N P F+ + P+++ V+E N
Sbjct: 672 --------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANAF 698
Query: 734 LARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVY 793
+ ++ ATDPDAG NG++ Y + GN F I G + A L+ E ++Y L V
Sbjct: 699 VGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVAT 755
Query: 794 DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNG 853
D + S L + V D +DN+P F Y + + E+ GTTI ++ KD D N
Sbjct: 756 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN- 814
Query: 854 RVRYTLLSPTEK--FSLHPLTGELVVTGHLDRES----EPRYILKVEARDQPSKGHQLFS 907
V Y + SP K F+LHP TGEL + LD E+ E VEA D G
Sbjct: 815 -VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPG 871
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT--FLDASDPDLGPAGEVRYVLM 965
+ + + ++D+ND P + V D GT +T + + +DP PA VRY +
Sbjct: 872 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 931
Query: 966 DGAH----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021
D F V+ +G +I L+ E + L + A D G P+ + V+++V
Sbjct: 932 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV- 989
Query: 1022 DVNENLHPPHFASFVHQ----GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGL 1077
LHP F + V E + GT V V++A + ++ + Y + +G
Sbjct: 990 -----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1040
Query: 1078 AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--------SSVTEVYIEVTD 1129
F IN TG+I PLD E + Y L V A D V L S+ +VYIE+ D
Sbjct: 1041 DTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQD 1099
Query: 1130 ANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-----ITSGNYMGF 1184
N++PP + + + EDA + TSVL++ A D D+ + + + I G
Sbjct: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EG 1157
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F++ TGL+ TA + +V D+ L + V+V +++ D I S+
Sbjct: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
Score = 247 bits (630), Expect = 2e-64
Identities = 273/1057 (25%), Positives = 469/1057 (44%), Gaps = 103/1057 (9%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTL-LSPT 863
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y + +P
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 864 EKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
+ L T L V+ D G +F L+ D +
Sbjct: 197 DPDRAQNLNERRTTT----------TTLTVDVLDGDDLG-PMFLPCVLVPNTRDCRPLTY 245
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPD--LGPAGEVRYVLMDGAHGT-------FRV 974
Q L+ PE+L P V + A D D + P + +L GT F +
Sbjct: 246 QAAIP--ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHM 303
Query: 975 DLMTGALILERELDFERRAGYNLSLWA-SDGGRPLARRTLCHVEVIVLDVNENLHPPHFA 1033
T L L ++ + ++L + A D G PL H+E++ +EN P+F
Sbjct: 304 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL----DENNQSPYFT 359
Query: 1034 SFVHQGQVQENSPSGTQV-----------IVVAAQDDDSGLDGELQYFLRAGTGLAAFSI 1082
+QG + E++P G + IV +D + D EL FL T + +
Sbjct: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419
Query: 1083 NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF 1142
T + L P+DRE Y ++ A D V S V I+V DANDN P + +
Sbjct: 420 TGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISY 477
Query: 1143 YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDR 1202
+ D G SV+QL A D D S G++T+ I G G F+I+ TGL++ A ++
Sbjct: 478 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEM 536
Query: 1203 ENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVND-NPPIFSHKLFNVRLPERLSPVS 1259
+ L V DN P+ + S V + +L N+ +PP F ++++ + E +
Sbjct: 537 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR--V 594
Query: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLVTGVVSSSSTF--TAGEYNILTI 1316
+ L A+D + +TY+IE+ D + F++ TG+++ + + IL I
Sbjct: 595 GAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 651
Query: 1317 KATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV--- 1373
A+D G+P +++ ++I + + P+ + +V+E + N VG +
Sbjct: 652 TASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKATDP 707
Query: 1374 -EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS--RTIA 1430
G G +++ G+ + F I + GSI A L+ R Y L V TDG+ +
Sbjct: 708 DAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
Query: 1431 TQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQD 1490
T + +I+ + P F + Y V V ++ G +L+++A D D G ++ Y I +
Sbjct: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI---RS 821
Query: 1491 PGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTVMVRDQEI--PIKRNFVWVTIHVED 1547
P F L P +G L + LD + P Q ++T +V +I + VT+ V+D
Sbjct: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD-RGVNA-EVHY---SLLKGNSEGF 1602
N +PP F++ Y+ V GT + V A DAD G+ A V Y +
Sbjct: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
Query: 1603 FNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATV-IIHVYPSDRSAPIFS 1661
F + G + L++ L V A D G P ATV I+ ++P + P F+
Sbjct: 942 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE--IPRFT 999
Query: 1662 KSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELREGNKDGVFSMNSYSGLISTQKKLD 1719
+ EY + E G+ + ++SA + ++ + Y + GN++ F +N+ +G+I LD
Sbjct: 1000 QEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
Query: 1720 HEKISSYQLKIRGSNMAGAFTDV---------MVVVDIIDENDNAPMFLKSTFVGQISEA 1770
+E +SY L+++ ++ ++ V ++I DEN++ P+F K ++G +SE
Sbjct: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1119
Query: 1771 APLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEP 1807
A +++ ++ + A+D D S++ Y+++ P
Sbjct: 1120 ARMFTSVLR-------VKATDKDTGNYSVMAYRLIIP 1149
Score = 246 bits (628), Expect = 4e-64
Identities = 300/1150 (26%), Positives = 480/1150 (41%), Gaps = 128/1150 (11%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSKFFQIN--GSTGEMSTVQELDYEAQQHFHVKVRAM 2352
A+D D G N + Y I + D + +N +T TV LD +
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGD------------ 222
Query: 2353 DKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL-----VLKVQAIDPD 2407
D G P+ ++V N D R Y+A + EL T L +QAID D
Sbjct: 223 DLG--PMFLPCVLVPNTRDC-------RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 273
Query: 2408 SR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG 2459
D + Y IL G + R F ++ + +S+ + ++L + A
Sbjct: 274 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 333
Query: 2460 ---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID---------LLAID 2507
A ++I + N SP F Y+ + E+A VG + D ++A+D
Sbjct: 334 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
Query: 2508 KDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENSTERVIAIKVMARDGGG 2564
KD + + + F++ G + LQ +DRE ++ + A DG
Sbjct: 394 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQ 451
Query: 2565 RVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
V I + D NDN P F Y V + +++ VIQ+ A DADEG N ++TY +
Sbjct: 452 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 511
Query: 2625 NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP--HWNSLVPVRLQVV 2682
+ IN TG++ + + + +T ++A D PP NS+ V ++V+
Sbjct: 512 LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
Query: 2683 -PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPESNKDGVF 2740
P S P+F + +Y+ E + G+ + ++A + D + Y++ G + VF
Sbjct: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG-----DPQRVF 624
Query: 2741 SLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEAD 2800
+L TG++ + K +D EST Y + + A D S +VNI V DVNDN PVF D
Sbjct: 625 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--D 681
Query: 2801 PYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
PY L N+ V V QV A D D G +GQV Y L N + LF I S +G
Sbjct: 682 PY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNNLFRITS-NG 732
Query: 2856 WITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915
I T +L+ E Y VVA D G S + + + D +DN+P F + Y V
Sbjct: 733 SIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
Query: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTL--- 2972
EN G + ++ D D+ V+ I + F + E +S ++L
Sbjct: 792 EENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYE 846
Query: 2973 ---DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
D+E + +L+ G + TV + V D+ND P S+ +Y G V D G
Sbjct: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
Query: 3029 FILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFN 3082
I V A D D +++ Y + A F+++ +G + T L+ E +F
Sbjct: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
Query: 3083 LVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFDNTTVKTPVAVVFARDP 3140
LV A D G + T+ + ++ PRF + V + T T V V+ A
Sbjct: 967 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1023
Query: 3141 DQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPI--- 3196
N +VYS+ + E F I+ TGVI + PL + L V+A L +
Sbjct: 1024 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1082
Query: 3197 ---PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKT-- 3251
S V + + ++ PVF + V EDA T VL++ + +
Sbjct: 1083 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1142
Query: 3252 GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF----LSIECSRKSSSSLSDV 3304
YR ++ ++G+ F ++ TG++ A L YF ++ + K S +DV
Sbjct: 1143 AYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1201
Query: 3305 TTVMVNITDV 3314
+VN D+
Sbjct: 1202 LVSVVNQLDM 1211
Score = 241 bits (614), Expect = 1e-62
Identities = 222/788 (28%), Positives = 352/788 (44%), Gaps = 50/788 (6%)
Query: 719 PQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGL---LTVA 775
P + +S+ + +PL R+ A D D + + F + +TG+ LT+
Sbjct: 372 PVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLL 429
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
P+D E Y ++T +D Q+S ++ + V D NDN P FP Y + + D
Sbjct: 430 QPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP 487
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTE-KFSLHPLTGELVVTGHLDRESEPRYILKVE 894
G ++ +LT DAD NG + Y +L + F ++ TG + + ++ Y L V+
Sbjct: 488 GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQ 547
Query: 895 ARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITE-HNRLKVPEDLPPGTVLTFLDASDPD 953
A D + S+ + I + N+ SP + L++ E + G VL L A+D +
Sbjct: 548 AADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
Query: 954 LGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRT 1012
+ Y + +G F + TG L L + LD E Y L + ASD GRP T
Sbjct: 608 ---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTST 663
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
V ++V DVN+N P F ++ + + V V A D D+G++G++ Y L
Sbjct: 664 -ATVNIVVTDVNDN--APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
Query: 1073 AGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDAND 1132
L + N G I T L+RE YY L V+A D P S + I+V D +D
Sbjct: 721 NFNNLFRITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
Query: 1133 NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG 1192
N P + + + ++E+ P GT++LQ++A D D + +++ I S FF +HP TG
Sbjct: 778 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA--NVSYRIRSPEVKHFFALHPFTG 835
Query: 1193 LLSTAQQLDRENKDEHILEVTVL----DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFN 1248
LS + LD E + +T L D + V V + D+ND PP+FS +++
Sbjct: 836 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
Query: 1249 VRLPERLSPVSPGPVYRLVASDLD-EGL-NGRVTYSIEDSD----EEAFSIDLVTGVVSS 1302
+ V P+ + A D D GL RV Y ++D F ++ +G V +
Sbjct: 896 GMVAP--DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 953
Query: 1303 SSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVME 1360
I L + A D G+P +S+S + I + P IP E Y V E
Sbjct: 954 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSE 1010
Query: 1361 TDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTV 1420
MVGVIS ++I G+++ F I TG I + PLD R++Y L V
Sbjct: 1011 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
Query: 1421 EVTD----------GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRV 1470
+ S++ +V+I I + N+H P F + Y V +D +LRV
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVYI-EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
Query: 1471 QAIDQDKG 1478
+A D+D G
Sbjct: 1130 KATDKDTG 1137
Score = 234 bits (598), Expect = 1e-60
Identities = 273/1078 (25%), Positives = 456/1078 (42%), Gaps = 149/1078 (13%)
Query: 799 QKSSWKLLTVNVKDWNDNAPRF------------PPGGYQLTISE---DTEVGTTIAELT 843
++++ LTV+V D +D P F P YQ I E E+ I
Sbjct: 207 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 266
Query: 844 TKDADSE-------DNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYIL 891
+ D + D + Y++L T + F +HP T EL + ++R+ ++ L
Sbjct: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 326
Query: 892 KVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT------ 945
++A + GH L + L I + D N+ SP + + E P G ++
Sbjct: 327 VIKA--EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
Query: 946 -----------FLDASDPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERR 992
D DP+L ++ ++ F V +T L L + +D E +
Sbjct: 385 SPLRIVALDKDIEDTKDPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 437
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVI 1052
Y S+ A DG + V + V+D N+N P F + V + G VI
Sbjct: 438 QTYTFSITAFDG---VQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVI 492
Query: 1053 VVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDR 1112
+ A D D G +GE+ Y + G F IN+ TG+I ++ Y LTV A D
Sbjct: 493 QLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 551
Query: 1113 G--SVPLSSVTEVYIEVTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
+ +S+ VYIEV N+ +PP+ Q ++ I E VG +L L A D + S
Sbjct: 552 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS- 610
Query: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229
+T+ I +G+ F + TG+L+ + LDRE+ D +IL +T D G P ST+ V
Sbjct: 611 --ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 667
Query: 1230 VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDS 1286
+ + DVNDN P+ F+ LP LS V V ++ A+D D G+NG+V YS+ +
Sbjct: 668 IVVTDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 722
Query: 1287 DEEAFSIDLVTGVVSSSSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPW 1339
+ + + S+ S +TA +Y L + ATD P +++ L I+ +
Sbjct: 723 NN-------LFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 775
Query: 1340 PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDI 1395
S + F + Y+ V E P ++ +E + N+S + + F +
Sbjct: 776 DDNSPV---FTNSTYTVLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 830
Query: 1396 EKTTGSIVIARPLDTR----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFL 1449
TG + + R LD + ++ VE D G+ ++ ++N + P F
Sbjct: 831 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 890
Query: 1450 ETRYEVRVPQDTVPGVELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGV 1505
+ Y+ V D V G + V A D D + Y + Q P AS+F+++ SG
Sbjct: 891 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 950
Query: 1506 LVTVGKLDLGSGPSQ-HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYE 1561
++T +++L P+ L V+ D P+ + V I V LHP PRFTQ Y
Sbjct: 951 VIT--RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYR 1004
Query: 1562 ASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA 1621
+A ++ V + A +N + YS++ GN E F IN + G+I + LD
Sbjct: 1005 PPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1061
Query: 1622 NHAPHTLTVKAE-------DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIP 1674
+ L V+A+ + P + A V I + + P+F K Y + E
Sbjct: 1062 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1121
Query: 1675 VGSPILLVSAMSPSEVTYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKIS 1724
+ + +L V A Y ++EG K+G F + +Y+GLI T + + S
Sbjct: 1122 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRS 1179
Query: 1725 SYQLKI-----RGSNMAGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
++ ++ G ++G ++ VV+ +D N P L + ++E Y
Sbjct: 1180 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1237
Score = 231 bits (590), Expect = 9e-60
Identities = 277/1128 (24%), Positives = 469/1128 (41%), Gaps = 134/1128 (11%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236
+P AQ L+ L V VLD + V+V +
Sbjct: 192 ---------QYNPDDP--DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP--NTR 238
Query: 1237 DNPPI-FSHKLFNVRLPERLSPVSPGPVYRLVASDLD-------EGLNGRVTYSIEDSDE 1288
D P+ + + +R PE L+P+ P + + D + G+ + +
Sbjct: 239 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 298
Query: 1289 EAFSIDLVTGVVSSSSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIP 1346
F + T +S + L IKA PL A LHIE + S
Sbjct: 299 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY- 357
Query: 1347 LAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD-------------- 1392
F Y ++E+ PV + P I DKD++
Sbjct: 358 --FTMPSYQGYILESAPVGATISDSLNLTSP----LRIVALDKDIEDTKDPELHLFLNDY 411
Query: 1393 ---FDIEKT--TGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQ 1447
F + +T T + + +P+D + Y ++ DG + + + + N + P
Sbjct: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471
Query: 1448 FLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGV 1505
F E Y+V V D PG ++++ A+D D+G + + Y I G+ F ++ ++G+
Sbjct: 472 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----VGAQGDFIINKTTGL 527
Query: 1506 LVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE---DGNLHPPRFTQLHYEA 1562
+ +++ G + + LTV D P +R T+++E N PPRF QL Y
Sbjct: 528 ITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 1563 SVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQAN 1622
+ + + G LL ++A D + + Y++ G+ + FN++ GI+TL + LD+ +
Sbjct: 587 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
Query: 1623 HAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFS----KSEYFVEIPESIPVGSP 1678
+ L + A D G P ATV I V + +AP+F ++ VE + VG
Sbjct: 644 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQ- 701
Query: 1679 ILLVSAMSPS-----EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGS 1733
V A P +V Y L GN + +F + S +G I T KL+ E Y+L + +
Sbjct: 702 ---VKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVAT 755
Query: 1734 NMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASD 1791
+ A + + + + ++D +DN+P+F ST+ + E P + I+ I A D
Sbjct: 756 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ-------IEAKD 808
Query: 1792 SDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMP----SFQFCVYVHDQGS 1847
D AN + Y+I PE FF + P G L+++ +DYE+ P S F V D
Sbjct: 809 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 866
Query: 1848 PVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED------S 1901
+ P A V + V+D+ND PP FS++IY+ + G + V A D D S
Sbjct: 867 TM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924
Query: 1902 EVNYSIKTGNADEAVTIHPV---TGSISV---LNPAFLGLSRKLTIRASDG--LYQDTAL 1953
V Y + +I V +G + LN + + + + DG + +A
Sbjct: 925 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 984
Query: 1954 VKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALV-ILGAQGNHLNDTLSYFLLNGT--D 2010
VKI + + +F Q+ Y L + +V ++ A +N ++ Y +++G D
Sbjct: 985 VKILVLHP-GEIPRFTQEEYRPPPVSELATKGTMVGVISAAA--INQSIVYSIVSGNEED 1041
Query: 2011 MFHMVQSAGVLQTRGVAFDREQQDTHELAVE-------VRDNRTPQRVAQGLVRVSIEDV 2063
F + GV+ G D E + ++ L V+ + + R P + V + I+D
Sbjct: 1042 TFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
Query: 2064 NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFA-----EDYTYFRI 2118
N++PP F+ Y + + + +V ATD+D G + Y E F +
Sbjct: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
Query: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNK 2166
+ Y G I F + + +VIA D L + +VLV+V N+
Sbjct: 1161 ETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1208
Score = 214 bits (544), Expect = 2e-54
Identities = 267/1095 (24%), Positives = 452/1095 (41%), Gaps = 101/1095 (9%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSMGTLTIVSEMDYESM-PSFQFCVYVHDQGSPVLFAP 1853
+ Y I +P+ + + T V +D + + P F CV V P
Sbjct: 186 QIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLV-----PNTRDC 240
Query: 1854 RPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNAD 1913
RP + ++ R E++ + + PI + ++ + + YSI G +
Sbjct: 241 RPLTYQAAIPEL-----RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 295
Query: 1914 EAVT---IHPVTGSISVLNPAFLGLSRK--LTIRAS-DGLYQDTALVKISLTQVLDKSLQ 1967
+ +HP T +S+L P +K L I+A D + A + + ++LD++ Q
Sbjct: 296 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI-EILDENNQ 354
Query: 1968 ---FDQDVYWAAVKE------------NLQDRKALVILGAQGNHLNDTLSYFLLNGTDMF 2012
F Y + E NL +V L D + LN
Sbjct: 355 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 414
Query: 2013 HMVQSAGVLQ--TRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKF 2070
V G+ + T DRE+Q T+ ++ D Q +V + + D NDN P F
Sbjct: 415 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTF 472
Query: 2071 KHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY-FRIDPYLGDISLKK 2129
+ Y + PGD + Q++A D D G+NG +TYE F I+ G I++
Sbjct: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 532
Query: 2130 PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR-----NKSNPLFQSPYYKVRVPENI 2184
+ Y L V A D P+ + V + N+S P F Y + + E +
Sbjct: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
Query: 2185 TLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVR 2244
+ +L+ QA EG + Y I +P +F TG+LT+ LD ES +++ +
Sbjct: 593 RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 652
Query: 2245 ATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRN 2304
A+D S ATV ++V DVNDN P F + A V Q+ A+D D+G N
Sbjct: 653 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
Query: 2305 RDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETL 2364
V Y + + + F+I S G + T +L+ E + ++ + V A D P
Sbjct: 713 GQVHYSL----GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT 767
Query: 2365 VVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQD 2424
+ + V DI+DN P F Y V E G +L+++A D D + + Y I S
Sbjct: 768 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL--GANVSYRIRSPEVK 825
Query: 2425 RHFFINSSSGIISMFNLCKKHL----DSSYNLRVGASDGVFRATVPVYINTT-----NAN 2475
F ++ +G +S+ ++S V A D T+P I T + N
Sbjct: 826 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMN 883
Query: 2476 KYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG--PYGTIDYTIINKLASEKFSI-- 2531
Y P F + +Y+ +A +A+ GT + + A D D P + Y + + SI
Sbjct: 884 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 943
Query: 2532 --NPNGQIATLQKLDRENSTERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKA 2587
+G++ T L+ E +T + + V+A D G V + TVKI++ + P+F
Sbjct: 944 VEEDSGRVITRVNLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1000
Query: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKD 2647
EY S ++ ++ V++ A N + YS+ + +D IN +TGV+ V
Sbjct: 1001 EEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGN-EEDTFGINNITGVIYVNG 1056
Query: 2648 SLVGLENQTLDFFIKAQDGG---------PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTF 2698
L E +T + ++ Q P ++ V +++ + P F + Y
Sbjct: 1057 PL-DYETRT-SYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1114
Query: 2699 SAPEDLPEGSEIGIVKAVAAQDPVIYSLV--RGTTP--ESNKDGVFSLDPDTGVIKVRKP 2754
ED + + VKA +D YS++ R P + K+G F ++ TG+IK
Sbjct: 1115 GVSEDARMFTSVLRVKA-TDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAML 1172
Query: 2755 MDHESTKLYQIDVMA 2769
+ ++ V+A
Sbjct: 1173 FHNMRRSYFKFQVIA 1187
Score = 205 bits (522), Expect = 7e-52
Identities = 232/853 (27%), Positives = 346/853 (40%), Gaps = 99/853 (11%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
A D D G +GQ+ Y + +P Q L+ T
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDP--------------DRAQNLNERRTTTTTLT 215
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
V D L L V + + D P Y+ ++ E P EL + T
Sbjct: 216 VDVLDGDD---LGPMFLPCVLVPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQ 268
Query: 2935 ISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISSRKTLDREHTAKYLLRV 2984
+Q+R + L + D R +S + ++R+ K+ L +
Sbjct: 269 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 328
Query: 2985 TASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI---------LK 3032
A A + I +LD N+ SP + Y G + E G I L+
Sbjct: 329 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 388
Query: 3033 VSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---ELTTLTALDRERKDVFN 3082
+ A D D + P H F D TG LT L +DRE + +
Sbjct: 389 IVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
Query: 3083 LVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQ 3142
A DG S + + V D NDN P F V V+ + V + A D D+
Sbjct: 442 FSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
Query: 3143 GANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP-LSTL 3201
G+N ++ Y + A+G F I+ TTG+I + +++ LTV+A+D P +++
Sbjct: 502 GSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 561
Query: 3202 GTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNE 3260
TV + V+ + P F +S+++ E G +L L R G T Y + +G+
Sbjct: 562 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSIT-YAIENGDP 620
Query: 3261 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQ 3320
Q F L TGIL + +LD E++ +Y L I S S TV + +TDVN++ P
Sbjct: 621 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-TATVNIVVTDVNDNAPV 679
Query: 3321 FPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPK 3374
F DPY R L NA VG V ATD D +N + YSL N L T
Sbjct: 680 F--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSLGNFNNLFRIT---S 730
Query: 3375 KGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTT 3434
G + A L+RE Y L + ATD P H +AI+V D++DN P F Y+
Sbjct: 731 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 790
Query: 3435 VQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRA 3493
V+EN P G+ +LQ+ D D G S+RI F + P G L L A
Sbjct: 791 VEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 847
Query: 3494 ----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQG 3547
+ ++A D +PP + +V V V + + Y P V D +G
Sbjct: 848 FPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 905
Query: 3548 GMVGKIHATDRDP 3560
+ ++A D DP
Sbjct: 906 TPITTVYAEDADP 918
Score = 197 bits (500), Expect = 2e-49
Identities = 251/1047 (23%), Positives = 423/1047 (40%), Gaps = 92/1047 (8%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
R + L+ R L++ DG C +++ +
Sbjct: 195 PDDPDRA----------QNLNERRTTTTTLTVDVLDGDDLGPMFLPC----VLVPNTRDC 240
Query: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGE-----LQYFLRAGTGL---AA 1079
P + + + + + E + A D D + + Y + GT
Sbjct: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Query: 1080 FSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQ 1139
F ++ T + L P++R+F + L + A PL + ++IE+ D N+ P +
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
Query: 1140 AVFYPSIQEDAPVG---------TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP- 1189
+ I E APVG TS L++ A D D ++ +Y F +
Sbjct: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
Query: 1190 -VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFN 1248
+T L+ Q +DRE + + +T D + S V + ++D NDN P F ++
Sbjct: 421 GITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYD 478
Query: 1249 VRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSS--TF 1306
V + + P V +L A D DEG NG +TY I + F I+ TG+++ +
Sbjct: 479 VYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM 536
Query: 1307 TAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPV 1364
G LT++A D+ P ++ ++IE +P P S P F + YS + E V
Sbjct: 537 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-PNNQS-PPRFPQLMYSLEISEAMRV 594
Query: 1365 NHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVT 1423
++ + R G + I GD F++ +TTG + + + LD Y L + +
Sbjct: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 654
Query: 1424 DG--SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSL 1481
DG T V+I ++ ++N + P F + + +V+A D D G +
Sbjct: 655 DGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--I 711
Query: 1482 IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWV 1541
+H S +LF++ S+G + T KL+ + L V+ D + + + + +
Sbjct: 712 NGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REVRDYYELVVVATDGAVHPRHSTLTL 768
Query: 1542 TIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEG 1601
I V D + + P FT Y V + + GT +LQ+ A D D G N V Y + +
Sbjct: 769 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 826
Query: 1602 FFNINALLGIITLAQKLDQA----NHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSA 1657
FF ++ G ++L + LD A T V+A D +ATV + V +
Sbjct: 827 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 886
Query: 1658 PIFSKSEYFVEIPESIPVGSPILLVSA-------MSPSEVTYELREGN---KDGVFSMNS 1707
P+FSK Y + G+PI V A + S V Y + + +F +
Sbjct: 887 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 946
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDI-IDENDNAPMFLKSTFVGQ 1766
SG + T+ L+ E + ++L + + V I + P F + +
Sbjct: 947 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY--- 1003
Query: 1767 ISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVS 1826
P S + K VI A+ N +VY I+ F I+ G + +
Sbjct: 1004 ---RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1056
Query: 1827 EMDYESMPSFQFCVYVHDQGSPVLFAPR------PAQVIIHVRDVNDSPPRFSEQIYEVA 1880
+DYE+ S+ V D VL R A+V I ++D N+ PP F ++ Y
Sbjct: 1057 PLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1115
Query: 1881 IVGPIHPGMELLMVRASDEDSEVNYSI 1907
+ +L V+A+D+D+ NYS+
Sbjct: 1116 VSEDARMFTSVLRVKATDKDTG-NYSV 1141
Score = 191 bits (484), Expect = 2e-47
Identities = 269/1109 (24%), Positives = 458/1109 (41%), Gaps = 130/1109 (11%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPM 1757
+ + Y+ + + +E+ + T + VD++D +D PM
Sbjct: 183 PNGQIEYVIQYNPDDPDRAQNLNERRT---------------TTTTLTVDVLDGDDLGPM 227
Query: 1758 FLKSTFVGQISEAAPLY------SMIMDKNNNPFV----IHASDSDKEANSL-----LVY 1802
FL V + PL + + NP + I A D D+ ++Y
Sbjct: 228 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 287
Query: 1803 KIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQFCVYV-HDQGSPVLFAPRPAQV 1858
IL PE +FF + P L+++ ++ + F + D G P+ P A +
Sbjct: 288 SILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL---PAFAGL 344
Query: 1859 IIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL---------LMVRASD------EDSEV 1903
I + D N+ P F+ Y+ I+ G + L + A D +D E+
Sbjct: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
Query: 1904 NYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT--IRASDGLYQ-DTALVKISLTQ 1960
+ + + VT +T +++L P + T I A DG+ + + +V I +
Sbjct: 405 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 464
Query: 1961 VLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNGTDMFHMVQSA 2018
D + F + Y V +++ +++ L A N ++Y +L G ++
Sbjct: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 524
Query: 2019 GVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDV---NDNPPKFKHLPY 2075
L T + T+ L V+ DN P + V IE + N +PP+F L Y
Sbjct: 525 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 584
Query: 2076 YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQA 2135
I + G VL + ATD + G + E + F + G ++L K D ++
Sbjct: 585 SLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
Query: 2136 LNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTP--- 2189
++Y L + A DG GT + + ++VT N + P+F PY +P N+++
Sbjct: 644 TDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPVF-DPY----LPRNLSVVEEEAN 696
Query: 2190 --ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVR 2244
+ +A P+ G+ ++ Y++ L T++ G + L+ E + + V
Sbjct: 697 AFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELVVV 753
Query: 2245 ATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
ATD A+ S T+ + V D++DN P F+ YT + E LPA T ++Q+ A D D G
Sbjct: 754 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 813
Query: 2304 NRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA----QQHFHVKVRAMDKGDPPL 2359
N VSY+I +V FF ++ TGE+S ++ LDYEA + V A D
Sbjct: 814 N--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 869
Query: 2360 TGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQA--IDPDSRDTSRLEYL 2417
G V V V D+ND PP F + Y+ V+ A G + V A DP SR+ Y
Sbjct: 870 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 929
Query: 2418 ILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYNLRVGASDG--VFRATVPVYINT 2471
+ F + SG +I+ NL ++ + V DG V ++ V I
Sbjct: 930 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 989
Query: 2472 TNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLAS 2526
+ + P F Q Y +ELA + MVG VI AI++ +I Y+I++
Sbjct: 990 LHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAAAINQ------SIVYSIVSGNEE 1040
Query: 2527 EKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-------GGGRVAFCTVKIILTDE 2578
+ F IN G I LD E T V+ ++ + + + V I + DE
Sbjct: 1041 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
Query: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYS--VNPEDLVKDVIEI 2636
N++PP F+ Y + + + V++V A D D G + + Y + P K+ +
Sbjct: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
Query: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
TG++K + F + A D
Sbjct: 1161 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
Score = 186 bits (472), Expect = 4e-46
Identities = 245/978 (25%), Positives = 414/978 (42%), Gaps = 116/978 (11%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAGTG--LAAFSINQ--DTGMIQTLAPLDREFASYYWLTVLAV--DRGSVPLSSVTEVY 1124
++ A ++N+ T T+ LD + +L + V R PL+ Y
Sbjct: 191 IQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT-----Y 245
Query: 1125 IEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG---NY 1181
P +++ + P IQ + D S + + ++I G +Y
Sbjct: 246 QAAIPELRTPEELNPIIVTPPIQ--------AIDQDRNIQPPSDRPGILYSILVGTPEDY 297
Query: 1182 MGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LDNGEPSLKSTSRVVVGILDVNDNPP 1240
FF +HP T LS + ++R+ + L + DNG P L + + + + ILD N+ P
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSP 356
Query: 1241 IFSHKLF----------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEA 1290
F+ + + + L+ SP R+VA D D IED+ +
Sbjct: 357 YFTMPSYQGYILESAPVGATISDSLNLTSP---LRIVALDKD----------IEDTKDPE 403
Query: 1291 FSIDL--VTGVVSSSSTFTAGEYNIL-------------TIKATDSGQPPLSASVRLHIE 1335
+ L T V + + T +L +I A D Q V + +
Sbjct: 404 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVM 463
Query: 1336 WIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGVISVEGRPGLFWFNISGGDKDMDFD 1394
P+ +++D Y +T M D V + V + EG G + I G + DF
Sbjct: 464 DANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 520
Query: 1395 IEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS-----RTIATQVHIFMIANINHHRPQFL 1449
I KTTG I IA ++ Y LTV+ D + R V+I ++ N P+F
Sbjct: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
Query: 1450 ETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTV 1509
+ Y + + + G LL +QA D++ G S+ Y I DP +F L ++G+L T+
Sbjct: 581 QLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENG-DP--QRVFNLSETTGIL-TL 635
Query: 1510 GKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRF-TQLHYEASVPDTI 1568
GK ++ L + D P + V I V D N + P F L SV +
Sbjct: 636 GKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 694
Query: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTL 1628
A + QV+A D D G+N +VHYSL GN F I + G I A KL++ + L
Sbjct: 695 A-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYEL 750
Query: 1629 TVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMS-- 1686
V A D H T+ I V D ++P+F+ S Y V + E++P G+ IL + A
Sbjct: 751 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
Query: 1687 -PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI----SSYQLKIRGSNMAGAFTD 1741
+ V+Y +R F+++ ++G +S + LD+E +S + ++ G
Sbjct: 811 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 870
Query: 1742 VMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEA--N 1797
+ V +I D ND P+F K + G ++ A K ++A D+D
Sbjct: 871 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-------KGTPITTVYAEDADPPGLPA 923
Query: 1798 SLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR 1854
S + Y++ + P F+++ G + ++ E F+ V D G PV+ +
Sbjct: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
Query: 1855 PAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPGMELLMVRASDEDSEVNYSIKTGNA 1912
++ ++H ++ PRF+++ Y V + G + ++ A+ + + YSI +GN
Sbjct: 984 TVKILVLHPGEI----PRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNE 1039
Query: 1913 DEAVTIHPVTGSISVLNP 1930
++ I+ +TG I V P
Sbjct: 1040 EDTFGINNITGVIYVNGP 1057
Score = 173 bits (439), Expect = 3e-42
Identities = 183/727 (25%), Positives = 307/727 (42%), Gaps = 72/727 (9%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNS 3008
+P D R + L+ T L V DG + + ++ N+
Sbjct: 193 YNP---------DDPDRAQN---LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP---NT 237
Query: 3009 PQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDTDTNAQ-------ITYSLHGPGAHE- 3057
C L Y + E P I+ +D D N Q I YS+ +
Sbjct: 238 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
Query: 3058 ---FKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPR 3112
F + P T EL+ L ++R+ F+LV KA G A LH+E D N+ +P
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
Query: 3113 F-FPSH---------CAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSI 3162
F PS+ + D+ + +P+ +V + ++ + F++
Sbjct: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
Query: 3163 DAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
T T + L +P+ Q ++ A D + S V + V+ D P F
Sbjct: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 474
Query: 3221 TEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGYRVVSGNEQGRFRLDARTGILYVNAS 3278
+ V V D PG V+QL + + Y ++ G QG F ++ TG++ +
Sbjct: 475 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 533
Query: 3279 LDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNITDVNEHRP-QFPQDPYSTRVLENAL 3335
++ Y L+++ + + + + + TV + + N P +FPQ YS + E
Sbjct: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
Query: 3336 VGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLK 3395
VG V+L + ATD +G ITY++ G+ F + G L + KALDRE Y L
Sbjct: 594 VGAVLLNLQATDREG---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
Query: 3396 LRATDSGQPPLHEDTDIAIQVADVNDNPPRF---FQLNYSTTVQE-NSPIGSKVLQLILS 3451
+ A+D G+P + I V DVNDN P F N S +E N+ +G Q+ +
Sbjct: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKAT 705
Query: 3452 DPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL 3511
DPD+ NG + + GN + FR+T +G + TA L+R +++Y+L + A+D + P
Sbjct: 706 DPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
Query: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEE 3571
S ++ + V + +P + V E+ G + +I A D D ++Y +
Sbjct: 763 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 822
Query: 3572 ETLGRHF 3578
E +HF
Sbjct: 823 EV--KHF 827
Score = 159 bits (401), Expect = 7e-38
Identities = 201/870 (23%), Positives = 359/870 (41%), Gaps = 131/870 (15%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
++RE + +YT I A + E E + V + ++D ND P F SY V + DM
Sbjct: 432 VDREEQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 490
Query: 167 ICKVTATDADLGQNAEFYYAFNTRSE-MFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
+ ++TA DAD G N E Y ++ F I+ T+G++T+A + + + L V A D
Sbjct: 491 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 550
Query: 226 RMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAE 285
N S+ + + V P + P ++ + ++ VL++ ++ E
Sbjct: 551 NAPPAERRN---SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
Query: 286 VESV--EVVGGDPGKHF------------KAIKSYARSNEFSLVSVKDIN-WMEYLHGFN 330
+S+ + GDP + F KA+ + +++ D N
Sbjct: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN 667
Query: 331 LSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA- 389
+ + + + P F + P LS ++ E + Q+ P V +
Sbjct: 668 IVVTDVNDNAPVFDPYL------PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGN 721
Query: 390 FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVIDIV 449
F NL + S KLN ++ D+++ P ++ + I ++
Sbjct: 722 FNNLFRITSNGSIYTAVKLN--------REVRDYYELVVVATDGAVHPRHSTLTLAIKVL 773
Query: 450 DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSID 508
D ++++P+F S+Y ++EN+P GT++L + A D D G N V+Y I P+ F++
Sbjct: 774 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 831
Query: 509 PYLGIISTSKPMDYEL---MKRIYTFRVRASD-WGSPFRREKEVSIFLQLRNLNDNQPMF 564
P+ G +S + +DYE + TF V A D +G+ V++ ++++ND P+F
Sbjct: 832 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVF 889
Query: 565 EEVNCTGSIRQDWPVGKSIMTMSAIDVD----ELQNLKYEIVSGNELEY------FDLNH 614
+ G + D G I T+ A D D ++Y + +++++ F++
Sbjct: 890 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPYPASIFEVEE 946
Query: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGKN--YASPTTLNITVVKDPHFEVPVTCDK 672
SG + + +NL T + L + A D +S T+ I V+
Sbjct: 947 DSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL------------H 991
Query: 673 TGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINT 732
G + +FT+ E++ P + L + T
Sbjct: 992 PGEIPRFTQ---------------------------------EEYRPPPVSELATK--GT 1016
Query: 733 PLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYI----- 787
+ ++A A N +VY I GNEE F I TG++ V PLDYE Y+
Sbjct: 1017 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
Query: 788 --LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTK 845
L V + +L P KS+ + + ++D N++ P F Y +SED + T++ +
Sbjct: 1073 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
Query: 846 DADSEDNGRVRYTLLSP-----TEKFSLHPLTGELVVTGHLDRESEPRYI-LKVEARDQP 899
D D+ + + Y L+ P E F + TG L+ T L Y +V A D
Sbjct: 1133 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFKFQVIATDDY 1191
Query: 900 SKGHQLFSVTDLIITLEDVNDNSPQCITEH 929
KG L D+++++ VN Q I +
Sbjct: 1192 GKG--LSGKADVLVSV--VNQLDMQVIVSN 1217
Score = 155 bits (392), Expect = 8e-37
Identities = 233/1010 (23%), Positives = 410/1010 (40%), Gaps = 179/1010 (17%)
Query: 94 FLRIRTKSSNTALL---NREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDLKPLFS 149
F + +++ +LL NR+ + L+I+A + L A + + ILD+N+ P F+
Sbjct: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 359
Query: 150 PPSYR----------VTISEDMPLKSPICKVTATDADL--GQNAEFYYAFNTRSEMFAIH 197
PSY+ TIS+ + L SP+ ++ A D D+ ++ E + N + +F +
Sbjct: 360 MPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT 418
Query: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIA 257
T G+ L R + + ++ + E P I
Sbjct: 419 QT-GITRYLTLLQPVDREEQQTYTFSITAFDGVQESE-------------------PVIV 458
Query: 258 SVVVTPPDSNDGT------TYATVLVDANSSGAEVESVEVVGGDPGKHFK--------AI 303
++ V D+ND T +Y + G V + V D G + + A
Sbjct: 459 NIQVM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 516
Query: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGP--------YFYSQIRGFHLPPS 355
+ + L+++ M + L++QA + P Y ++ LPP+
Sbjct: 517 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV----LPPN 572
Query: 356 KLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTP-AFPNLQYVLKPSSENVGFKLNARTGL 414
S +F + +Y +++SE G+ ++ ++ T ++ Y ++ F L+ TG+
Sbjct: 573 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGI 632
Query: 415 ITTTKLMDFHDRAHYQLHIRTSPGQ----ASTVVVIDIVDCNNHAPLFNRSSYDGTLDEN 470
+T K +D Y L I S G+ ++ V I + D N++AP+F D
Sbjct: 633 LTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF---------DPY 683
Query: 471 IPPGTSVL---------AVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMD 521
+P SV+ V ATD D G NG V YS+ L F I G I T+ ++
Sbjct: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL-FRITSN-GSIYTAVKLN 741
Query: 522 YELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGK 581
E ++ Y V A+D G+ R +++ +++ +++DN P+F T + ++ P G
Sbjct: 742 RE-VRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 799
Query: 582 SIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPF-INLTAGQPTSYSLKI 640
+I+ + A DVD N+ Y I S +F L+ F+G +SL R Q S + +
Sbjct: 800 TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
Query: 641 TASDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEF 699
A D P +TV VKD
Sbjct: 860 EAFDIYGTMPPGIATVTVIVKD-------------------------------------- 881
Query: 700 TSLSTYQINHYTPQFEDHFPQSI---DVLESVPINTPLARLAATDPDAGFNGKLVYVIAD 756
+N Y P F + + D ++ PI T A A DP ++ Y + D
Sbjct: 882 -------MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA--DPPGLPASRVRYRVDD 932
Query: 757 GN---EEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDW 813
F++E ++G + L+ E T + L V +D G P SS + + V
Sbjct: 933 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
Query: 814 NDNAPRFPPGGYQ-LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHP 870
+ PRF Y+ +SE GT + ++ + N + Y+++S E+ F ++
Sbjct: 993 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1047
Query: 871 LTGELVVTGHLDRESEPRYILKVEARD---------QPSKGHQLFSVTDLIITLEDVNDN 921
+TG + V G LD E+ Y+L+V+A PSK + + I ++D N++
Sbjct: 1048 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS----NTAKVYIEIQDENNH 1103
Query: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLM-----DGAHGTFRVDL 976
P + V ED T + + A+D D G + Y L+ +G G F V+
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVET 1162
Query: 977 MTGALILERELDFERRAGYNLSLWASDG-GRPLARRTLCHVEVIVLDVNE 1025
TG + RR+ + + A+D G+ L+ + +V+V VN+
Sbjct: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK----ADVLVSVVNQ 1208
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 717 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 776
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 777 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 836
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 837 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 956 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1012
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1013 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1073 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1133 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1189
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 610 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 659
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 660 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 719
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 720 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 776
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 777 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 821
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 882 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 937
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 938 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 988
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 989 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1044
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1045 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1164 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1216
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 489 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 544 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 659
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 660 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 718 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 776 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 829 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1006 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1061 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1116
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1236
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1237 DVLVSV 1242
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1121
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1180
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1181 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1240 VSVVNQ 1245
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
Query: 1807 P 1807
P
Sbjct: 1186 P 1186
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 55 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 467 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 521
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 522 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 580
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 637
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 638 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 695
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 696 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 753
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 754 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 807 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 984 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1039 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1094
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1095 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1154
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1155 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1214
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1215 DVLVSV 1220
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 350 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 409 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 462 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 520 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 631
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 632 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 689
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 747
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 808 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 866
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 867 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 925
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 926 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 985
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 986 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1040
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1099
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1100 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1158
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1159 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1217
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1218 VSVVNQ 1223
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 115 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 175 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 235 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 295 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 355 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 411 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 468
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 529 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 588 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 642
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 643 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 699
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 700 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 755
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 816 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 993 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1050
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1163
Query: 1807 P 1807
P
Sbjct: 1164 P 1164
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 91 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 150
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 151 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 210
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 211 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 270
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 271 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 323
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 324 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 379
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 380 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 436
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 437 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 555
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 556 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 615
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 616 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 671
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 672 RPDGTSTATVNIVVT--------------------------------------------- 686
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 687 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 742
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 743 I-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 860 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 918 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 977
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 978 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1086
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1087 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1146 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1203
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1204 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 93 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 152
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 153 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 212
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 272
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 273 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 332
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 333 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 392
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 393 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 451
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 452 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 510
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 511 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 568
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 628
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 629 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 682
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 683 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 735 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 790
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 791 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 847
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 848 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1026 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1081
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1082 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1141
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1142 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1200
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1201 IATDDYGKGLSGKADVLVSVVNQLDM 1226
Score = 253 bits (647), Expect = 2e-66
Identities = 323/1296 (24%), Positives = 542/1296 (41%), Gaps = 180/1296 (13%)
Query: 601 IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK 660
I+ G+ E + G I + I TAG P +++++ D +Y V+
Sbjct: 15 IILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDP-TIELSLKDNVDY--------WVLM 65
Query: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQI-------NHYTPQ 713
DP ++ VL + +H I +Q Q +++ ++ +++ N +P
Sbjct: 66 DPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQ-CINKKVGTIIYHEVRIVVRDRNDNSPT 124
Query: 714 FEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGNEEGCFD 764
F+ H V E P+ T + ATD D G NG++ YVI D F+
Sbjct: 125 FK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFE 183
Query: 765 IELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWNDNAPRF 820
I L TG + + L+YE Y + + D ++++ LTV+V D +D P F
Sbjct: 184 IPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF 243
Query: 821 ------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DNGRVRYT 858
P YQ I E E+ I + D + D + Y+
Sbjct: 244 LPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYS 303
Query: 859 LLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
+L T + F +HP T EL + ++R+ ++ L ++A + GH L + L I
Sbjct: 304 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHI 361
Query: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDASDPDLGP 956
+ D N+ SP + + E P G ++ D DP+L
Sbjct: 362 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL-- 419
Query: 957 AGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPLARRTLC 1014
++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 420 -----HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---VQESEPV 471
Query: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
V + V+D N+N P F + V + G VI + A D D G +GE+ Y + G
Sbjct: 472 IVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529
Query: 1075 TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIEVTDAND 1132
F IN+ TG+I ++ Y LTV A D + +S+ VYIEV N+
Sbjct: 530 -AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 588
Query: 1133 -NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT 1191
+PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F + T
Sbjct: 589 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 645
Query: 1192 GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRL 1251
G+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+ F+ L
Sbjct: 646 GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV-----FDPYL 699
Query: 1252 PERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTA 1308
P LS V V ++ A+D D G+NG+V YS+ + + + + S+ S +TA
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSNGSIYTA 752
Query: 1309 -------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
+Y L + ATD P +++ L I+ + S + F + Y+ V E
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEEN 809
Query: 1362 DPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR----RR 1413
P ++ +E + N+S + + F + TG + + R LD +
Sbjct: 810 LPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 867
Query: 1414 SNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
++ VE D G+ ++ ++N + P F + Y+ V D V G + V
Sbjct: 868 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
Query: 1472 AIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVM 1526
A D D + Y + Q P AS+F+++ SG ++T +++L P+ L V+
Sbjct: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTIFKLVVV 985
Query: 1527 VRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
D P+ + V I V LHP PRFTQ Y +A ++ V + A
Sbjct: 986 AFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1040
Query: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE-------DQG 1636
+N + YS++ GN E F IN + G+I + LD + L V+A+ +
Sbjct: 1041 --INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 1637 SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE--- 1693
P + A V I + + P+F K Y + E + + +L V A Y
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 1694 -------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNMAGAFTD 1741
++EG K+G F + +Y+GLI T + + S ++ ++ G ++G
Sbjct: 1159 YRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
Query: 1742 VMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
++ VV+ +D N P L + ++E Y
Sbjct: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1252
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 332 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 451 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 507 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 623 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 676
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 677 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 734
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 735 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1029
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1030 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1084
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1085 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1205 DYGK--GLSGKADVLVSVVNQLD 1225
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 134
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 193
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 253 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 312
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 313 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 372
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 373 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 433 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 489
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 543
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 544 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 602 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 654
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 655 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 712
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 713 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 766
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 767 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 827 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1004 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1058
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1176
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1177 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 233 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 291
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 412 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 469
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 470 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 527
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 528 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 586
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 587 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 645
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 646 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 704
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 705 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 759
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 877
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 878 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 938 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 998 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1047
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1048 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1106
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1156
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 89 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 147
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 148 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 207
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 208 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 267
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 268 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 327
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 328 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 387
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 388 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 440
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 441 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 560
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 561 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 620
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 621 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 678
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 679 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 732
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 733 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 846
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 847 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 904
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 905 SKRIYKGMVAPDAVKGTPITTVYAEDADP 933
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 108 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 163
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 283 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 342
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 343 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 462 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 520 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 579
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 580 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 639
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 754
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 755 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 814
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 815 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 873 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 930
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 931 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 988
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1045 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1101
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1160
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1161 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1202
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 103 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 160
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 161 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 220
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 221 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 280
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 281 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 340
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 341 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 458 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 517
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 518 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 577
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 578 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 636
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 694
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 695 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 746
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 862
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 863 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 922
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 983 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1039
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1040 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 227
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 348 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 464
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 525 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 640
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 700 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 752
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 813 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 842
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 732 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 851
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 852 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 971 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1027
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1028 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1204
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 625 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 674
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 791
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 792 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 837 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 896
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 897 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1003
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1059
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1060 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1179 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1231
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 489 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 544 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 659
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 660 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 718 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 776 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 829 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1006 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1061 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1116
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1236
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1237 DVLVSV 1242
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1121
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1180
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1181 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1240 VSVVNQ 1245
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
Query: 1807 P 1807
P
Sbjct: 1186 P 1186
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 82 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 136
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 494 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 548
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 549 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 607
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 664
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 665 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 722
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 723 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 781 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 834 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1011 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1066 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1121
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1122 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1181
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1182 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1241
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1242 DVLVSV 1247
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 377 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 436 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 489 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 547 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 658
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 659 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 716
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 717 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 774
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 834
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 835 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 893
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 894 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 952
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 953 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1012
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1013 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1067
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1068 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1126
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1127 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1185
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1186 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1244
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1245 VSVVNQ 1250
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 142 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 202 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 382 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 438 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 495
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 496 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 555
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 556 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 614
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 615 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 669
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 670 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 726
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 727 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 782
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 843 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 899
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 900 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1020 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1077
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1078 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1190
Query: 1807 P 1807
P
Sbjct: 1191 P 1191
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 118 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 177
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 178 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 237
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 297
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 298 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 350
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 351 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 406
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 463
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 464 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 523
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 524 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 582
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 583 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 643 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 698
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 699 RPDGTSTATVNIVVT--------------------------------------------- 713
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 714 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 769
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 770 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 828
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 829 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 886
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 887 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 944
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 945 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 1004
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1005 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1058 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1113
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1114 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1172
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1173 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1230
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1231 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1259
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 179
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 180 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 239
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 299
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 300 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 359
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 360 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 419
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 420 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 478
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 479 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 537
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 538 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 595
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 596 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 655
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 656 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 709
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 710 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 761
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 762 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 817
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 818 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 874
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 875 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 932
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 933 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 992
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 993 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1052
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1053 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1108
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1109 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1168
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1169 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1227
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1228 IATDDYGKGLSGKADVLVSVVNQLDM 1253
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 146 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 204
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 205 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 264
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 265 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 324
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 325 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 382
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 383 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 442
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 443 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 492
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 493 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 550
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 551 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 610 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 666
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 721
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 722 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 773
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 830
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 831 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 888
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 889 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1006
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1007 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1062
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1063 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1119
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1120 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1179
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1180 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1237
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1238 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1279
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 197 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 428
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 429 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 487
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 488 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 547
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 548 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 602
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 659
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 718
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 719 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 772
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 773 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 831
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 832 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 882
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 883 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 940
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 941 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1000
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 1001 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1060 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1116
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1117 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1176
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1177 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1236
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1237 LSGKADVLVSVVNQ 1250
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 359 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 478 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 533
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 534 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 590
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 650 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 703
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 704 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 761
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 762 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 877
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1056
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1057 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1111
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1112 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1172 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1232 DYGK--GLSGKADVLVSVVNQLD 1252
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 161
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 220
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 280 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 339
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 340 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 399
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 400 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 459
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 460 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 516
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 517 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 570
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 571 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 629 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 681
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 682 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 739
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 740 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 793
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 794 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 853
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 854 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 911
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 912 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 971
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1030
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1031 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1085
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1086 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1145
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1146 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1203
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1204 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 260 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 318
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 439 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 496
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 497 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 554
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 555 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 613
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 614 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 672
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 673 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 731
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 732 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 786
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 847 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 904
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 905 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 964
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 965 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1024
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1025 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1074
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1075 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1133
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1183
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 116 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 174
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 175 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 234
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 235 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 294
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 295 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 354
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 355 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 415 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 467
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 468 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 527
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 528 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 587
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 588 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 647
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 648 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 705
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 706 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 759
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 760 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 816
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 817 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 873
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 874 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 931
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 932 SKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 135 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 190
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 310 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 369
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 370 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 429 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 489 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 547 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 606
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 607 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 666
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 727 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 781
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 782 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 841
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 842 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 899
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 900 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 957
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 958 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1015
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1071
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1072 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1128
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1129 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1187
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1188 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1229
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 130 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 187
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 188 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 247
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 248 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 368 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 425 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 484
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 485 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 544
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 545 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 604
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 605 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 663
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 664 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 721
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 722 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 773
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 834 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 889
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 890 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 949
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 950 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1009
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1010 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1066
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1067 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1120
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 138 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 376 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 431
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 432 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 481
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 482 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 539
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 540 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 598
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 599 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 657
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 658 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 712
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 713 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 769
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 770 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 828
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 829 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 888
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 889 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 945
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 946 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1001
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 1002 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1057
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1058 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1099
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 491
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 492 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 551
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 552 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 667
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 668 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 727 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 779
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 840 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 869
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 759 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 818
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 819 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 878
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 879 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 998 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1054
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1055 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1114
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1115 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1174
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1175 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1231
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 652 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 701
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 702 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 761
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 762 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 818
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 819 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 863
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 864 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 923
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 924 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 979
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 980 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1030
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1031 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1086
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1087 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1145
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1146 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1205
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1206 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1258
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 489 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 544 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 659
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 660 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 718 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 776 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 829 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1006 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1061 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1116
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1236
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1237 DVLVSV 1242
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1121
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1180
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1181 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1240 VSVVNQ 1245
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
Query: 1807 P 1807
P
Sbjct: 1186 P 1186
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 55 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 467 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 521
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 522 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 580
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 637
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 638 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 695
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 696 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 753
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 754 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 807 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 984 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1039 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1094
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1095 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1154
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1155 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1214
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1215 DVLVSV 1220
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 350 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 409 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 462 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 520 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 631
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 632 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 689
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 747
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 808 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 866
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 867 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 925
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 926 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 985
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 986 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1040
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1099
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1100 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1158
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1159 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1217
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1218 VSVVNQ 1223
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 115 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 175 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 235 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 295 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 355 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 411 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 468
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 529 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 588 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 642
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 643 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 699
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 700 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 755
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 816 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 993 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1050
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1163
Query: 1807 P 1807
P
Sbjct: 1164 P 1164
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 91 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 150
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 151 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 210
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 211 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 270
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 271 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 323
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 324 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 379
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 380 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 436
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 437 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 555
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 556 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 615
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 616 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 671
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 672 RPDGTSTATVNIVVT--------------------------------------------- 686
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 687 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 742
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 743 I-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 860 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 918 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 977
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 978 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1086
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1087 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1146 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1203
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1204 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 93 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 152
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 153 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 212
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 272
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 273 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 332
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 333 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 392
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 393 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 451
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 452 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 510
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 511 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 568
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 628
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 629 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 682
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 683 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 735 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 790
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 791 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 847
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 848 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1026 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1081
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1082 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1141
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1142 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1200
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1201 IATDDYGKGLSGKADVLVSVVNQLDM 1226
Score = 253 bits (647), Expect = 2e-66
Identities = 323/1296 (24%), Positives = 542/1296 (41%), Gaps = 180/1296 (13%)
Query: 601 IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK 660
I+ G+ E + G I + I TAG P +++++ D +Y V+
Sbjct: 15 IILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDP-TIELSLKDNVDY--------WVLM 65
Query: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQI-------NHYTPQ 713
DP ++ VL + +H I +Q Q +++ ++ +++ N +P
Sbjct: 66 DPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQ-CINKKVGTIIYHEVRIVVRDRNDNSPT 124
Query: 714 FEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGNEEGCFD 764
F+ H V E P+ T + ATD D G NG++ YVI D F+
Sbjct: 125 FK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFE 183
Query: 765 IELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWNDNAPRF 820
I L TG + + L+YE Y + + D ++++ LTV+V D +D P F
Sbjct: 184 IPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF 243
Query: 821 ------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DNGRVRYT 858
P YQ I E E+ I + D + D + Y+
Sbjct: 244 LPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYS 303
Query: 859 LLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
+L T + F +HP T EL + ++R+ ++ L ++A + GH L + L I
Sbjct: 304 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHI 361
Query: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDASDPDLGP 956
+ D N+ SP + + E P G ++ D DP+L
Sbjct: 362 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL-- 419
Query: 957 AGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPLARRTLC 1014
++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 420 -----HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---VQESEPV 471
Query: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
V + V+D N+N P F + V + G VI + A D D G +GE+ Y + G
Sbjct: 472 IVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529
Query: 1075 TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIEVTDAND 1132
F IN+ TG+I ++ Y LTV A D + +S+ VYIEV N+
Sbjct: 530 -AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 588
Query: 1133 -NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT 1191
+PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F + T
Sbjct: 589 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 645
Query: 1192 GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRL 1251
G+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+ F+ L
Sbjct: 646 GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV-----FDPYL 699
Query: 1252 PERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTA 1308
P LS V V ++ A+D D G+NG+V YS+ + + + + S+ S +TA
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSNGSIYTA 752
Query: 1309 -------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
+Y L + ATD P +++ L I+ + S + F + Y+ V E
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEEN 809
Query: 1362 DPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR----RR 1413
P ++ +E + N+S + + F + TG + + R LD +
Sbjct: 810 LPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 867
Query: 1414 SNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
++ VE D G+ ++ ++N + P F + Y+ V D V G + V
Sbjct: 868 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
Query: 1472 AIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVM 1526
A D D + Y + Q P AS+F+++ SG ++T +++L P+ L V+
Sbjct: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTIFKLVVV 985
Query: 1527 VRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
D P+ + V I V LHP PRFTQ Y +A ++ V + A
Sbjct: 986 AFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1040
Query: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE-------DQG 1636
+N + YS++ GN E F IN + G+I + LD + L V+A+ +
Sbjct: 1041 --INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 1637 SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE--- 1693
P + A V I + + P+F K Y + E + + +L V A Y
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 1694 -------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNMAGAFTD 1741
++EG K+G F + +Y+GLI T + + S ++ ++ G ++G
Sbjct: 1159 YRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
Query: 1742 VMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
++ VV+ +D N P L + ++E Y
Sbjct: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1252
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 332 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 451 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 507 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 564 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 623 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 676
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 677 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 734
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 735 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1029
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1030 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1084
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1085 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1205 DYGK--GLSGKADVLVSVVNQLD 1225
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 134
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 193
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 253 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 312
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 313 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 372
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 373 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 433 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 489
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 543
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 544 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 602 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 654
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 655 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 712
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 713 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 766
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 767 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 827 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1004 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1058
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1176
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1177 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 233 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 291
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 412 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 469
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 470 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 527
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 528 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 586
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 587 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 645
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 646 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 704
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 705 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 759
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 877
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 878 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 938 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 998 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1047
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1048 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1106
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1156
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 89 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 147
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 148 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 207
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 208 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 267
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 268 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 327
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 328 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 387
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 388 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 440
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 441 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 560
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 561 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 620
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 621 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 678
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 679 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 732
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 733 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 846
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 847 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 904
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 905 SKRIYKGMVAPDAVKGTPITTVYAEDADP 933
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 108 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 163
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 283 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 342
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 343 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 462 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 520 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 579
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 580 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 639
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 754
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 755 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 814
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 815 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 873 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 930
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 931 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 988
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1045 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1101
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1160
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1161 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1202
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 103 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 160
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 161 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 220
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 221 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 280
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 281 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 340
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 341 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 458 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 517
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 518 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 577
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 578 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 636
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 694
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 695 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 746
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 862
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 863 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 922
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 983 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1039
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1040 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 227
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 348 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 464
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 525 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 640
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 700 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 752
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 813 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 842
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 732 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 851
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 852 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 971 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1027
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1028 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1204
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 625 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 674
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 791
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 792 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 837 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 896
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 897 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1003
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1059
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1060 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1179 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1231
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 489 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 544 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 659
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 660 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 718 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 776 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 829 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1006 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1061 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1116
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1236
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1237 DVLVSV 1242
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1121
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1180
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1181 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1240 VSVVNQ 1245
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
Query: 1807 P 1807
P
Sbjct: 1186 P 1186
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 489 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 544 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 659
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 660 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 718 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 776 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 829 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1006 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1061 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1116
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1236
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1237 DVLVSV 1242
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1121
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1180
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1181 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1240 VSVVNQ 1245
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
Query: 1807 P 1807
P
Sbjct: 1186 P 1186
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 266 bits (681), Expect = 3e-70
Identities = 322/1206 (26%), Positives = 520/1206 (43%), Gaps = 139/1206 (11%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 82 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 136
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2298 DQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD--- 2353
D+D +D + + D + V Q G T ++ +Q +D E QQ + + A D
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSR 2413
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 494 ESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 548
Query: 2414 LEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPVY 2468
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + VY
Sbjct: 549 ITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 607
Query: 2469 INTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE 2527
I N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQR 664
Query: 2528 KFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQF 2585
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P F
Sbjct: 665 VFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF 722
Query: 2586 KASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVV 2643
Y S V +++ V QV A D D G N V YS+ + + + + V
Sbjct: 723 --DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 2644 KVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
K L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 781 K-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 834 EENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 2761 KLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
+ V A + T + +V + V D+ND PVF YK ++ + GT +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 2817 IQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDA 2933
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 1011 VVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF-- 2991
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 1066 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVL 1121
Query: 2992 --------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTN 3043
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 1122 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1181
Query: 3044 AQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQA 3097
+ + Y L P G F ++ +TG + T R+ F ATD G G S +A
Sbjct: 1182 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1241
Query: 3098 DITLHV 3103
D+ + V
Sbjct: 1242 DVLVSV 1247
Score = 266 bits (681), Expect = 3e-70
Identities = 306/1146 (26%), Positives = 495/1146 (43%), Gaps = 121/1146 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 377 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 436 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 489 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 547 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 658
Query: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 659 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 716
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 717 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 774
Query: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 834
Query: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 835 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 893
Query: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 894 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 952
Query: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 953 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1012
Query: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1013 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1067
Query: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ-------- 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1068 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1126
Query: 3404 PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYS 3463
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N +
Sbjct: 1127 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMA 1185
Query: 3464 FR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVR 3518
+R I +G G T G + TA + +++ Q+ A+D LS V
Sbjct: 1186 YRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1244
Query: 3519 VHVTEQ 3524
V V Q
Sbjct: 1245 VSVVNQ 1250
Score = 266 bits (679), Expect = 4e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 142 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 202 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 382 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 438 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 495
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 496 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 555
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 556 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 614
Query: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 615 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 669
Query: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 670 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 726
Query: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 727 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 782
Query: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 843 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 899
Query: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 900 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1020 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1077
Query: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1078 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1190
Query: 1807 P 1807
P
Sbjct: 1191 P 1191
Score = 260 bits (665), Expect = 2e-68
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 118 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 177
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 178 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 237
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 297
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 298 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 350
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 351 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 406
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 463
Query: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 464 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 523
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 524 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 582
Query: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 583 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 643 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 698
Query: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
+ + S T+NI V
Sbjct: 699 RPDGTSTATVNIVVT--------------------------------------------- 713
Query: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 714 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 769
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 770 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 828
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 829 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 886
Query: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 887 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 944
Query: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 945 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 1004
Query: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 1005 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1058 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1113
Query: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1114 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1172
Query: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1173 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1230
Query: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
D+ L + V+V +++ D I S+
Sbjct: 1231 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1259
Score = 257 bits (657), Expect = 2e-67
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 179
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 180 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 239
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 299
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 300 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 359
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 360 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 419
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 420 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 478
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 479 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 537
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 538 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 595
Query: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 596 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 655
Query: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 656 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 709
Query: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 710 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 761
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 762 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 817
Query: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 818 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 874
Query: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 875 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 932
Query: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 933 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 992
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 993 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1052
Query: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 1053 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1108
Query: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 1109 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1168
Query: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 1169 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1227
Query: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
++ + K S +DV +VN D+
Sbjct: 1228 IATDDYGKGLSGKADVLVSVVNQLDM 1253
Score = 253 bits (646), Expect = 3e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 146 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 204
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 205 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 264
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 265 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 324
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 325 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 382
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 383 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 442
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 443 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 492
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 493 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 550
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 551 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 610 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 666
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 721
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 722 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 773
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 830
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 831 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 888
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 889 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1006
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1007 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1062
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1063 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1119
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1120 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1179
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1180 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1237
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1238 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1279
Score = 237 bits (604), Expect = 2e-61
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 197 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 428
Query: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 429 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 487
Query: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 488 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 547
Query: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 548 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 602
Query: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 659
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 718
Query: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 719 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 772
Query: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 773 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 831
Query: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 832 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 882
Query: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 883 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 940
Query: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
G + V A D D S V Y + +I V +G + LN
Sbjct: 941 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1000
Query: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 1001 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1060 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1116
Query: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 1117 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1176
Query: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1177 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1236
Query: 2153 LQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1237 LSGKADVLVSVVNQ 1250
Score = 232 bits (592), Expect = 5e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 359 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 478 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 533
Query: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 534 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 590
Query: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 591 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 650 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 703
Query: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 704 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 761
Query: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 762 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 877
Query: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1056
Query: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 1057 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1111
Query: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 1112 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 1172 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Query: 2879 DHGQTIQLSSQALVQVSITDEND 2901
D+G+ LS +A V VS+ ++ D
Sbjct: 1232 DYGK--GLSGKADVLVSVVNQLD 1252
Score = 223 bits (567), Expect = 4e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 161
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 220
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 280 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 339
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 340 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 399
Query: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 400 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 459
Query: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 460 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 516
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 517 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 570
Query: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 571 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 629 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 681
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 682 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 739
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 740 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 793
Query: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 794 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 853
Query: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 854 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 911
Query: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 912 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 971
Query: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1030
Query: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 1031 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1085
Query: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 1086 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1145
Query: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 1146 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1203
Query: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1204 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 220 bits (560), Expect = 3e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 260 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 318
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 439 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 496
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 497 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 554
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 555 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 613
Query: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 614 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 672
Query: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 673 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 731
Query: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 732 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 786
Query: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 847 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 904
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 905 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 964
Query: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 965 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1024
Query: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1025 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1074
Query: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1075 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1133
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1183
Score = 218 bits (554), Expect = 1e-55
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 116 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 174
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 175 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 234
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 235 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 294
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 295 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 354
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 355 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 415 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 467
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 468 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 527
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 528 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 587
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 588 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 647
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 648 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 705
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 706 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 759
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 760 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 816
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 817 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 873
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 874 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 931
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 932 SKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Score = 213 bits (542), Expect = 3e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 135 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 190
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 310 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 369
Query: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 370 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
Query: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 429 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 489 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 547 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 606
Query: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 607 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 666
Query: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 727 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 781
Query: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 782 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 841
Query: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 842 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 899
Query: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 900 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 957
Query: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 958 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1015
Query: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1071
Query: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 1072 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1128
Query: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 1129 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1187
Query: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1188 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1229
Score = 200 bits (509), Expect = 2e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 130 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 187
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 188 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 247
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 248 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 368 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
Query: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 425 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 484
Query: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 485 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 544
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 545 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 604
Query: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 605 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 663
Query: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 664 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 721
Query: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 722 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 773
Query: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 834 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 889
Query: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 890 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 949
Query: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 950 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1009
Query: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 1010 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1066
Query: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 1067 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1120
Query: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
+ + Y + P K+ + TG++K + F + A D
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 196 bits (499), Expect = 3e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 138 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
Query: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 376 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 431
Query: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
VA D D IED+ + + L T V + + T +L
Sbjct: 432 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 481
Query: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 482 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 539
Query: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 540 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 598
Query: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 599 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 657
Query: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 658 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 712
Query: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 713 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 769
Query: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 770 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 828
Query: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 829 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 888
Query: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 889 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 945
Query: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 946 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1001
Query: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 1002 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1057
Query: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1058 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1099
Score = 179 bits (454), Expect = 5e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 491
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 492 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 551
Query: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 552 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 667
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 668 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 727 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 779
Query: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
G + +I A D D ++Y + E +HF
Sbjct: 840 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 869
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 759 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 818
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 819 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 878
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 879 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 998 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1054
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1055 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1114
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1115 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1174
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1175 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1231
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 652 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 701
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 702 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 761
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 762 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 818
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 819 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 863
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 864 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 923
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 924 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 979
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 980 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1030
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1031 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1086
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1087 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1145
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1146 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1205
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1206 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1258
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 266 bits (680), Expect = 3e-70
Identities = 304/1148 (26%), Positives = 492/1148 (42%), Gaps = 118/1148 (10%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSL 2726
G P + + ++++ + P F+ P Y E P G+ I ++ P+
Sbjct: 377 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS--DSLNLTSPLRIVA 433
Query: 2727 VRGTTPESNKDGVFSLDPD----------------TGVIK---VRKPMDHESTKLYQIDV 2767
+ + GV + DP+ TG+ + + +P+D E + Y +
Sbjct: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 2768 MAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTG 2827
A V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G
Sbjct: 494 TA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551
Query: 2828 RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL- 2886
+G+++Y + + F I+ +G IT ++ +TY V A D+ +
Sbjct: 552 SNGEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
Query: 2887 SSQALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCY 2945
+S V + + N+ +P RF Y + E G ++ L+ D + +T
Sbjct: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYA 663
Query: 2946 ITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLD 3003
I GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V D
Sbjct: 664 IENGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTD 721
Query: 3004 VNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPH 3063
VNDN+P L + F+ +V ATD D N Q+ YSL G + F++ +
Sbjct: 722 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN 780
Query: 3064 TGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVA 3121
G + T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V
Sbjct: 781 -GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
Query: 3122 VFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP-- 3179
V +N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 840 VEENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFP 898
Query: 3180 --QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 899 DQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 957
Query: 3238 LQLAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLS 3290
+ PG A + YRV F ++ +G + +L+ E + + L
Sbjct: 958 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1017
Query: 3291 IECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDED 3349
+ +S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 1018 VVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA--- 1073
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQ------ 3403
+N I YS++ GN+ F I+ G + V LD E +SY L+++A DS +
Sbjct: 1074 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANL 1131
Query: 3404 --PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPP 3461
P + I++ D N++PP F + Y V E++ + + VL++ +D D+ N
Sbjct: 1132 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSV 1190
Query: 3462 YSFR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTS 3516
++R I +G G T G + TA + +++ Q+ A+D LS
Sbjct: 1191 MAYRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249
Query: 3517 VRVHVTEQ 3524
V V V Q
Sbjct: 1250 VLVSVVNQ 1257
Score = 262 bits (670), Expect = 5e-69
Identities = 284/1088 (26%), Positives = 489/1088 (44%), Gaps = 121/1088 (11%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 142 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 202 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSG---------TQVIVVAAQDDD 1060
H+E++ +EN P+F +QG + E++P G T + + A D D
Sbjct: 382 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 1061 ------SGL---DGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
SG+ D EL FL T + + T + L P+DRE Y ++ A D
Sbjct: 438 IEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 497
Query: 1112 RGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGK 1171
V S V I+V DANDN P + + + D G SV+QL A D D S G+
Sbjct: 498 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 555
Query: 1172 LTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVV 1229
+T+ I G G F+I+ TGL++ A ++ + L V DN P+ + S V
Sbjct: 556 ITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 614
Query: 1230 VGILDVND-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD- 1287
+ +L N+ +PP F ++++ + E + + L A+D + +TY+IE+ D
Sbjct: 615 IEVLPPNNQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDP 669
Query: 1288 EEAFSIDLVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSI 1345
+ F++ TG+++ + + IL I A+D G+P +++ ++I + +
Sbjct: 670 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNA 726
Query: 1346 PLAFDETYYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGS 1401
P+ + +V+E + N VG + G G +++ G+ + F I + GS
Sbjct: 727 PVFDPYLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGS 782
Query: 1402 IVIARPLDTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQ 1459
I A L+ R Y L V TDG+ +T + +I+ + P F + Y V V +
Sbjct: 783 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 842
Query: 1460 DTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519
+ G +L+++A D D G ++ Y I + P F L P +G L + LD + P
Sbjct: 843 NLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPD 899
Query: 1520 QH-TLTVMVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQ 1576
Q ++T +V +I + VT+ V+D N +PP F++ Y+ V GT +
Sbjct: 900 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 959
Query: 1577 VRAMDAD-RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVK 1631
V A DAD G+ A V Y + F + G + L++ L V
Sbjct: 960 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1019
Query: 1632 AEDQGSPQWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE 1689
A D G P ATV I+ ++P + P F++ EY + E G+ + ++SA + ++
Sbjct: 1020 AFDDGEPVMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
Query: 1690 -VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV------ 1742
+ Y + GN++ F +N+ +G+I LD+E +SY L+++ ++ ++
Sbjct: 1078 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137
Query: 1743 ---MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL 1799
V ++I DEN++ P+F K ++G +SE A +++ ++ + A+D D S+
Sbjct: 1138 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSV 1190
Query: 1800 LVYKILEP 1807
+ Y+++ P
Sbjct: 1191 MAYRLIIP 1198
Score = 261 bits (666), Expect = 1e-68
Identities = 324/1213 (26%), Positives = 522/1213 (43%), Gaps = 146/1213 (12%)
Query: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 82 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 136
Query: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2298 DQD------SG-RNRDVSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKV 2349
D+D SG +D + + D + V Q G T ++ +Q +D E QQ + +
Sbjct: 435 DKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSI 493
Query: 2350 RAMD---KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDP 2406
A D + +P +V + V D NDN P F + Y+ V G V+++ A+D
Sbjct: 494 TAFDGVQESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
Query: 2407 DSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----F 2461
D + Y IL G Q F IN ++G+I++ + + +Y L V A+D
Sbjct: 549 DEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
Query: 2462 RATVPVYINTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI 2520
+ VYI N S P F Q +Y E++E VG +++L A D++ +I Y I
Sbjct: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAI 664
Query: 2521 INKLASEKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDE 2578
N F+++ I TL K LDRE ST+R I I + A DG + TV I++TD
Sbjct: 665 ENGDPQRVFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDV 722
Query: 2579 NDNPPQFKASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEI 2636
NDN P F Y S V +++ V QV A D D G N V YS+ + + +
Sbjct: 723 NDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 2637 NPVTGVVKVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
+ VK L + D++ + A DG +S + + ++V+ + P F+
Sbjct: 781 GSIYTAVK-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
Query: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRK 2753
YT E+LP G+ I + A+D + + V F+L P TG + + +
Sbjct: 834 STYTVLVEENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLR 890
Query: 2754 PMDHESTKLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTEN 2809
+D+E+ + V A + T + +V + V D+ND PVF YK ++ +
Sbjct: 891 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 950
Query: 2810 MPVGTSVIQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCET 2867
GT + V A D D +V YR+ +F ++ +SG + T L+ E
Sbjct: 951 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
Query: 2868 CQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVA 2926
+ VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V
Sbjct: 1011 TTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVG 1068
Query: 2927 TLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTA 2986
+ + N+ + I G+ FGI+ + ++ LD E Y+LRV A
Sbjct: 1069 VISA-----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQA 1121
Query: 2987 SDGKF----------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSAT 3036
+ + V I + D N++ P + Y G V ED +L+V AT
Sbjct: 1122 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
Query: 3037 DLDTDTNAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--G 3090
D DT + + Y L P G F ++ +TG + T R+ F ATD G
Sbjct: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYG 1241
Query: 3091 GGRSCQADITLHV 3103
G S +AD+ + V
Sbjct: 1242 KGLSGKADVLVSV 1254
Score = 259 bits (662), Expect = 4e-68
Identities = 306/1233 (24%), Positives = 513/1233 (41%), Gaps = 186/1233 (15%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 118 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 177
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 178 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 237
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 297
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 298 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 350
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 351 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 406
Query: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYV----LKPSSENVGFKLNARTGLITT 417
+ E +P G+ + +R+ +++ V + + LN T + T
Sbjct: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTV 466
Query: 418 TKL-----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSY 463
T+ +D ++ Y I G + +V I ++D N++ P F SY
Sbjct: 467 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 526
Query: 464 DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYE 523
D + ++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++
Sbjct: 527 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM- 585
Query: 524 LMKRIYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGK 581
++ R Y V+A+D P R + +++++ L N + P F ++ + I + VG
Sbjct: 586 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 645
Query: 582 SIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKIT 641
++ + A D E ++ Y I +G+ F+L+ +G+++L + L Y L IT
Sbjct: 646 VLLNLQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIIT 701
Query: 642 ASDGK-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFT 700
ASDG+ + S T+NI V
Sbjct: 702 ASDGRPDGTSTATVNIVVT----------------------------------------- 720
Query: 701 SLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEE 760
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN
Sbjct: 721 -----DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFN 772
Query: 761 GCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRF 820
F I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 773 NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 831
Query: 821 PPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVT 878
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL +
Sbjct: 832 TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 889
Query: 879 GHLDRES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKV 934
LD E+ E VEA D G + + + ++D+ND P + V
Sbjct: 890 RSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 947
Query: 935 PEDLPPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELD 988
D GT +T + + +DP PA VRY + D F V+ +G +I L+
Sbjct: 948 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1007
Query: 989 FERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQEN 1044
E + L + A D G P+ + V+++V LHP F + V E
Sbjct: 1008 EEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSEL 1060
Query: 1045 SPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYW 1104
+ GT V V++A + ++ + Y + +G F IN TG+I PLD E + Y
Sbjct: 1061 ATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1116
Query: 1105 LTVLAVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV 1156
L V A D V L S+ +VYIE+ D N++PP + + + EDA + TSV
Sbjct: 1117 LRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1175
Query: 1157 LQLDAWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILE 1211
L++ A D D+ + + + I G F++ TGL+ TA + +
Sbjct: 1176 LRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1233
Query: 1212 VTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
V D+ L + V+V +++ D I S+
Sbjct: 1234 VIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
Score = 254 bits (650), Expect = 1e-66
Identities = 309/1173 (26%), Positives = 496/1173 (42%), Gaps = 130/1173 (11%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 179
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 180 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 239
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 299
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 300 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 359
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 360 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 419
Query: 2501 ID---------LLAIDKD------SG-PYGTIDYTIINKLASEKFSINPNG---QIATLQ 2541
D ++A+DKD SG P + + + F++ G + LQ
Sbjct: 420 SDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 479
Query: 2542 KLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKD 2601
+DRE ++ + A DG V I + D NDN P F Y V + +++
Sbjct: 480 PVDREE--QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 537
Query: 2602 SPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFI 2661
VIQ+ A DADEG N ++TY + + IN TG++ + + + +T +
Sbjct: 538 DSVIQLTAVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTV 595
Query: 2662 KAQDGGPP--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA 2718
+A D PP NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A
Sbjct: 596 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 655
Query: 2719 Q-DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
+ D + Y++ G + VF+L TG++ + K +D EST Y + + A D
Sbjct: 656 EGDSITYAIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 709
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQV 2832
S +VNI V DVNDN PVF DPY L N+ V V QV A D D G +GQV
Sbjct: 710 TSTATVNIVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQV 764
Query: 2833 SYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALV 2892
Y L N + LF I S +G I T +L+ E Y VVA D G S +
Sbjct: 765 HYSL-----GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTL 817
Query: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPL 2952
+ + D +DN+P F + Y V EN G + ++ D D+ V+ I +
Sbjct: 818 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVK 874
Query: 2953 GQFGISQVGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVN 3005
F + E +S ++L D+E + +L+ G + TV + V D+N
Sbjct: 875 HFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 932
Query: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFK 3059
D P S+ +Y G V D G I V A D D +++ Y + A F+
Sbjct: 933 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 992
Query: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSH 3117
++ +G + T L+ E +F LV A D G + T+ + ++ PRF +
Sbjct: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1052
Query: 3118 CAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQ 3176
V + T T V V+ A N +VYS+ + E F I+ TGVI + PL
Sbjct: 1053 RPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1108
Query: 3177 VRPQAPLELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ L V+A L + S V + + ++ PVF + V ED
Sbjct: 1109 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1168
Query: 3231 APPGTEVLQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSP 3285
A T VL++ + + YR ++ ++G+ F ++ TG++ A L
Sbjct: 1169 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRR 1227
Query: 3286 KYF----LSIECSRKSSSSLSDVTTVMVNITDV 3314
YF ++ + K S +DV +VN D+
Sbjct: 1228 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Score = 254 bits (648), Expect = 2e-66
Identities = 303/1182 (25%), Positives = 499/1182 (42%), Gaps = 156/1182 (13%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 146 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 204
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 205 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 264
Query: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 265 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 324
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 325 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 382
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT------------FLDASDPDLG 955
L I + D N+ SP + + E P G ++ LD D+
Sbjct: 383 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVP 442
Query: 956 PAG-----EVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
P+G ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 443 PSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 499
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 500 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 557
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 558 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 616
Query: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 617 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 673
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 674 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 728
Query: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 729 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 780
Query: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 837
Query: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 838 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 895
Query: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 955
Query: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1013
Query: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1014 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1069
Query: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1070 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1126
Query: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1127 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1186
Query: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1187 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1244
Query: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1245 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1286
Score = 240 bits (612), Expect = 3e-62
Identities = 250/955 (26%), Positives = 419/955 (43%), Gaps = 129/955 (13%)
Query: 406 FKLNARTGLITTTKLM--DFHDRAHYQLHIRTSPGQ---ASTVVVIDIVDCNNHAPLFNR 460
F ++ RT ++ + + DFH + + G A + I+I+D NN +P F
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 461 SSYDGTLDENIPPG---------TSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYL 511
SY G + E+ P G TS L + A D+D + P+ L ++ Y
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE-LHLFLNDYT 461
Query: 512 GIISTSK-----------PMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDN 560
+ + ++ P+D E ++ YTF + A D + + V + +Q+ + NDN
Sbjct: 462 SVFTVTQTGITRYLTLLQPVDRE-EQQTYTFSITAFDG---VQESEPVIVNIQVMDANDN 517
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGV 618
P F E++ + D G S++ ++A+D DE N + YEI+ G + ++ +N +G+
Sbjct: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGL 576
Query: 619 ISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQ 678
I++ P + + G+ +Y+L + A+D A P
Sbjct: 577 ITIA-PGVEMIVGR--TYALTVQAADN---APPA-------------------------- 604
Query: 679 FTKTILHFIGLQNQESSDEEFTSLSTYQINHYTP--QFEDHFPQ---SIDVLESVPINTP 733
E S+ T I P Q FPQ S+++ E++ +
Sbjct: 605 ------------------ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 646
Query: 734 LARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVY 793
L L ATD + + Y I +G+ + F++ TG+LT+ LD E+T+ YIL +T
Sbjct: 647 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 703
Query: 794 DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNG 853
D G P +S + + V D NDNAP F P + + E + ++ D D+ NG
Sbjct: 704 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 762
Query: 854 RVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
+V Y+L + F + G + L+RE Y L V A D H S L I
Sbjct: 763 QVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAI 819
Query: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFR 973
+ D++DNSP + V E+LP GT + ++A D DLG R + H F
Sbjct: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH-FFA 878
Query: 974 VDLMTGALILERELDFE----RRAGYNLSLWASD--GGRPLARRTLCHVEVIVLDVNENL 1027
+ TG L L R LD+E + A + A D G P T V VIV D+N+
Sbjct: 879 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND-- 933
Query: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGELQYF----LRAGTGLAAFSI 1082
+PP F+ +++G V ++ GT + V A+D D GL + ++ + F +
Sbjct: 934 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 993
Query: 1083 NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF 1142
+D+G + T L+ E + + L V+A D G +SS V I V + P +
Sbjct: 994 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYR 1053
Query: 1143 YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDR 1202
P + E A GT V + A ++ + ++I SGN F I+ +TG++ LD
Sbjct: 1054 PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1109
Query: 1203 ENKDEHI-------LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERL 1255
E + ++ LEV + + PS +T++V + I D N++PP+F K + + E
Sbjct: 1110 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1169
Query: 1256 SPVSPGPVYRLVASDLDEGLNGRVTYSI----EDSDEEAFSIDLVTGVVSSSSTF 1306
+ V R+ A+D D G + Y + +E F ++ TG++ ++ F
Sbjct: 1170 RMFT--SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222
Score = 234 bits (597), Expect = 1e-60
Identities = 281/1161 (24%), Positives = 483/1161 (41%), Gaps = 156/1161 (13%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 197 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
D + G+ + + F + T +S + L IKA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 428
Query: 1381 WFNISGGDKDMD------------------------FDIEKT--TGSIVIARPLDTRRRS 1414
I DKD++ F + +T T + + +P+D +
Sbjct: 429 -LRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 487
Query: 1415 NYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAID 1474
Y ++ DG + + + + N + P F E Y+V V D PG ++++ A+D
Sbjct: 488 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 547
Query: 1475 QDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEI 1532
D+G + + Y I G+ F ++ ++G++ +++ G + + LTV D
Sbjct: 548 ADEGSNGEITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAP 602
Query: 1533 PIKRNFVWVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAE 1589
P +R T+++E N PPRF QL Y + + + G LL ++A D +
Sbjct: 603 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 659
Query: 1590 VHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIH 1649
+ Y++ G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I
Sbjct: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 718
Query: 1650 VYPSDRSAPIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKD 1700
V + +AP+F ++ VE + VG V A P +V Y L GN +
Sbjct: 719 VTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFN 772
Query: 1701 GVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMF 1758
+F + S +G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F
Sbjct: 773 NLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 831
Query: 1759 LKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPS 1818
ST+ + E P + I+ I A D D AN + Y+I PE FF + P
Sbjct: 832 TNSTYTVLVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPF 882
Query: 1819 MGTLTIVSEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874
G L+++ +DYE+ P S F V D + P A V + V+D+ND PP FS+
Sbjct: 883 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSK 940
Query: 1875 QIYEVAIVGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSI 1925
+IY+ + G + V A D D S V Y + +I V +G +
Sbjct: 941 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000
Query: 1926 SV---LNPAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980
LN + + + + DG + +A VKI L + +F Q+ Y
Sbjct: 1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSE 1059
Query: 1981 LQDRKALV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHE 2037
L + +V ++ A +N ++ Y +++G D F + GV+ G D E + ++
Sbjct: 1060 LATKGTMVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYV 1116
Query: 2038 LAVE-------VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF 2090
L V+ + + R P + V + I+D N++PP F+ Y + + +
Sbjct: 1117 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
Query: 2091 QVSATDEDLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIA 2145
+V ATD+D G + Y E F ++ Y G I F + + +VIA
Sbjct: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1236
Query: 2146 RDGGTPSLQSEEEVLVTVRNK 2166
D L + +VLV+V N+
Sbjct: 1237 TDDYGKGLSGKADVLVSVVNQ 1257
Score = 230 bits (586), Expect = 3e-59
Identities = 252/930 (27%), Positives = 416/930 (44%), Gaps = 86/930 (9%)
Query: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 359 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 2088 VL---------FQVSATD---EDLGTNGAVTYE-----FAEDYTYFRIDPYLGD---ISL 2127
+ ++ A D ED+ +G T + F DYT G ++L
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
Query: 2128 KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPEN 2183
+P D + Y + A DG +Q E V+V ++ N + P F Y V V +
Sbjct: 478 LQPVDREEQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTD 533
Query: 2184 ITLYTPILH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTK 2238
+ ++ T + EG + E L+ DF TG++T+ ++
Sbjct: 534 MRPGDSVIQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 590
Query: 2239 HVFTVRATDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQ 2293
+ TV+A D A S +EVL + N +PP F QL+Y+ ISE + ++
Sbjct: 591 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 649
Query: 2294 LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
L A+D++ ++Y I + D + F ++ +TG ++ + LD E+ + + + A D
Sbjct: 650 LQATDREGD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 704
Query: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTS 2412
G P T V + V+D+NDN P F P N+S + V +V+A DPD+
Sbjct: 705 -GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGING 762
Query: 2413 RLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYI 2469
++ Y + GN + F I S+ I + L ++ D Y L V A+DG +T+ + I
Sbjct: 763 QVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAI 819
Query: 2470 NTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKF 2529
+ + SP F Y + EN GT ++ + A D D G + Y I + F
Sbjct: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFF 877
Query: 2530 SINP-NGQIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQ 2584
+++P G+++ L+ LD E E I V A D G + TV +I+ D ND PP
Sbjct: 878 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 937
Query: 2585 FKASEYTVSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVT 2640
F Y + + K +P+ V A DAD G A V Y V+ + E+ +
Sbjct: 938 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997
Query: 2641 GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
G V + +L + A D G P +S V++ V+ +P+F++ Y
Sbjct: 998 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPP 1056
Query: 2701 PEDLP-EGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
+L +G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+
Sbjct: 1057 VSELATKGTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYET 1111
Query: 2760 TKLYQIDVMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPV 2812
Y + V A L+ N V S V I++ D N++ PVF+ Y ++E+ +
Sbjct: 1112 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1171
Query: 2813 GTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYH 2872
TSV++V A DKDTG ++YRL P E F +++ +G I T +
Sbjct: 1172 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1231
Query: 2873 FHVVAY-DHGQTIQLSSQALVQVSITDEND 2901
F V+A D+G+ LS +A V VS+ ++ D
Sbjct: 1232 FQVIATDDYGK--GLSGKADVLVSVVNQLD 1259
Score = 219 bits (559), Expect = 4e-56
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 87/869 (10%)
Query: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 116 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 174
Query: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 175 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 234
Query: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 235 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 294
Query: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
P EL + T +Q+R + L + D R +S
Sbjct: 295 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 354
Query: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 355 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
G I L++ A D D + P H F D TG
Sbjct: 415 VGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRY 474
Query: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 475 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 534
Query: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 535 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 594
Query: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 595 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 654
Query: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 655 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 712
Query: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 713 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 766
Query: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 767 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 823
Query: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 824 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 880
Query: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 881 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 938
Query: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
V D +G + ++A D DP
Sbjct: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADP 967
Score = 219 bits (558), Expect = 5e-56
Identities = 305/1199 (25%), Positives = 502/1199 (41%), Gaps = 151/1199 (12%)
Query: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 161
Query: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
+EL G V++ DP S DT + L+L+GN
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 220
Query: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 280 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 339
Query: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 340 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 399
Query: 2585 FKASEYT----------VSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVI 2634
F Y +I +++ SP ++++A D D DV S P + +
Sbjct: 400 FTMPSYQGYILESAPVGATISDSLNLTSP-LRIVALDKDI---EDVPPSGVPTKDPELHL 455
Query: 2635 EINPVTGVVKVKDSLVGL-----------ENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP 2683
+N T V V + + E QT F I A DG + V V +QV+
Sbjct: 456 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 513
Query: 2684 KKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGV 2739
+ P F E Y D+ G + + AV A + + Y ++ G G
Sbjct: 514 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGD 567
Query: 2740 FSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRP 2795
F ++ TG+I + ++ + Y + V A N S+ +V I+V N+ P
Sbjct: 568 FIINKTTGLITIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSP 625
Query: 2796 V-FEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSE 2853
F Y ++E M VG ++ + A D++ ++Y + + DP +F +
Sbjct: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSET 678
Query: 2854 SGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
+G +T + LD E+ Y + A D +S A V + +TD NDNAP F R
Sbjct: 679 TGILTLGKALDRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRN 736
Query: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
V E V +K D D N QV + + G+ F I+ G I + L+
Sbjct: 737 LSVVEEEANAFVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLN 790
Query: 2974 REHTAKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI 3030
RE Y L V A+DG +++T+ I VLD++DNSP + YT V E++ G I
Sbjct: 791 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 850
Query: 3031 LKVSATDLDTDTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVA 3085
L++ A D+D N ++Y + P H F L P TGEL+ L +LD E ++ +
Sbjct: 851 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
Query: 3086 KATDGGGRSCQ--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
+A D G A +T+ V+D+ND P F V + TP+ V+A D D
Sbjct: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 968
Query: 3144 A--NAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP 3197
++V Y + D + F ++ +G + L P +L V A D G P+
Sbjct: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV- 1027
Query: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYR 3254
+S+ TV + V+ + +P F E+ V E A GT V + A + + Y
Sbjct: 1028 MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYS 1082
Query: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTV 3307
+VSGNE+ F ++ TG++YVN LD+ET Y L ++ + S S+ V
Sbjct: 1083 IVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1142
Query: 3308 MVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----G 3362
+ I D N H P F + Y V E+A + +L V ATD+D S + Y LI
Sbjct: 1143 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1202
Query: 3363 GNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
G + F + G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1203 GKE--GFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
Score = 214 bits (545), Expect = 1e-54
Identities = 270/1078 (25%), Positives = 449/1078 (41%), Gaps = 110/1078 (10%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 260 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 318
Query: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 1167 SS---KGKLT----FNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDN 1217
G T ++ +Y F + +T L+ Q +DRE + + +T D
Sbjct: 439 EDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 498
Query: 1218 GEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNG 1277
+ S V + ++D NDN P F ++V + + P V +L A D DEG NG
Sbjct: 499 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNG 554
Query: 1278 RVTYSIEDSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLH 1333
+TY I + F I+ TG+++ + G LT++A D+ P ++ ++
Sbjct: 555 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 614
Query: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMD 1392
IE +P P S P F + YS + E V ++ + R G + I GD
Sbjct: 615 IEVLP-PNNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 672
Query: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLE 1450
F++ +TTG + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 673 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDP 731
Query: 1451 TRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVG 1510
+ + +V+A D D G + +H S +LF++ S+G + T
Sbjct: 732 YLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAV 787
Query: 1511 KLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAP 1570
KL+ + L V+ D + + + + + I V D + + P FT Y V + +
Sbjct: 788 KLN-REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 846
Query: 1571 GTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPH 1626
GT +LQ+ A D D G N V Y + + FF ++ G ++L + LD A
Sbjct: 847 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 904
Query: 1627 TLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-- 1684
T V+A D +ATV + V + P+FSK Y + G+PI V A
Sbjct: 905 TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 964
Query: 1685 -----MSPSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA 1736
+ S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 965 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1024
Query: 1737 GAFTDVMVVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKE 1795
V I + P F + + P S + K VI A+
Sbjct: 1025 EPVMSSSATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----A 1074
Query: 1796 ANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR- 1854
N +VY I+ F I+ G + + +DYE+ S+ V D VL R
Sbjct: 1075 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1133
Query: 1855 -----PAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
A+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1134 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1190
Score = 209 bits (531), Expect = 6e-53
Identities = 269/1135 (23%), Positives = 458/1135 (40%), Gaps = 137/1135 (12%)
Query: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 135 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 190
Query: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
+ + V D +D P F I E+ ++P + +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 310 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 369
Query: 1941 IRASD----------GL------------------YQDTALVKISLTQVLDKSLQFDQDV 1972
I+A GL YQ L + + SL +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 1973 YWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDR 2030
A+ ++++D + G D + LN V G+ + T DR
Sbjct: 430 RIVALDKDIED------VPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 483
Query: 2031 EQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF 2090
E+Q T+ ++ D Q +V + + D NDN P F + Y + PGD +
Sbjct: 484 EEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
Query: 2091 QVSATDEDLGTNGAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
Q++A D D G+NG +TYE F I+ G I++ + Y L V A D
Sbjct: 542 QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 601
Query: 2150 TPSLQSEEEVLVTV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLI 2204
P+ + V + N+S P F Y + + E + + +L+ QA EG +
Sbjct: 602 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSIT 661
Query: 2205 YNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVED 2264
Y I +P +F TG+LT+ LD ES +++ + A+D S ATV ++V D
Sbjct: 662 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTD 721
Query: 2265 VNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQI 2324
VNDN P F + A V Q+ A+D D+G N V Y + + + F+I
Sbjct: 722 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI 777
Query: 2325 NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384
S G + T +L+ E + ++ + V A D P + + V DI+DN P F Y
Sbjct: 778 T-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
Query: 2385 EANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKK 2444
V E G +L+++A D D + + Y I S F ++ +G +S+
Sbjct: 837 TVLVEENLPAGTTILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
Query: 2445 HL----DSSYNLRVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAM 2495
++S V A D T+P I T + N Y P F + +Y+ +A +A+
Sbjct: 895 EAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 952
Query: 2496 VGTKVIDLLAIDKDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENST 2549
GT + + A D D P + Y + + SI +G++ T L+ E +T
Sbjct: 953 KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT 1012
Query: 2550 ERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQV 2607
+ + V+A D G V + TVKI++ + P+F EY S ++ ++ V
Sbjct: 1013 --IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1069
Query: 2608 LAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG 2667
++ A N + YS+ + +D IN +TGV+ V L E +T + ++ Q
Sbjct: 1070 ISAAA---INQSIVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADS 1123
Query: 2668 ---------PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA 2718
P ++ V +++ + P F + Y ED + + VKA
Sbjct: 1124 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TD 1182
Query: 2719 QDPVIYSLV--RGTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
+D YS++ R P + K+G F ++ TG+IK + ++ V+A
Sbjct: 1183 KDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1236
Score = 197 bits (502), Expect = 1e-49
Identities = 278/1138 (24%), Positives = 472/1138 (41%), Gaps = 144/1138 (12%)
Query: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 130 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 187
Query: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 188 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 247
Query: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 248 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
Query: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
Query: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 368 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
Query: 1892 ----LMVRASD-------------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG 1934
L + A D +D E++ + + VT +T +++L P
Sbjct: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 484
Query: 1935 LSRKLT--IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILG 1991
+ T I A DG+ + + +V I + D + F + Y V +++ +++ L
Sbjct: 485 EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 544
Query: 1992 A--QGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
A N ++Y +L G ++ L T + T+ L V+ DN P
Sbjct: 545 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 604
Query: 2050 RVAQGLVRVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVT 2106
+ V IE + N +PP+F L Y I + G VL + ATD + G +
Sbjct: 605 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYA 663
Query: 2107 YEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTV 2163
E + F + G ++L K D ++ ++Y L + A DG GT + + ++VT
Sbjct: 664 IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTD 721
Query: 2164 RNKSNPLFQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLML 2215
N + P+F PY +P N+++ + +A P+ G+ ++ Y++ L
Sbjct: 722 VNDNAPVF-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFR 776
Query: 2216 FTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQ 2274
T++ G + L+ E + + V ATD A+ S T+ + V D++DN P F+
Sbjct: 777 ITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
Query: 2275 LVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTV 2334
YT + E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S +
Sbjct: 834 STYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLL 889
Query: 2335 QELDYEA----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSE 2390
+ LDYEA + V A D G V V V D+ND PP F + Y+ V+
Sbjct: 890 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 949
Query: 2391 LATCGHLVLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKK 2444
A G + V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
Query: 2445 HLDSSYNLRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVG 2497
+ V DG V ++ V I + + P F Q Y +ELA + MVG
Sbjct: 1010 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG 1068
Query: 2498 TKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIK 2556
VI AI++ +I Y+I++ + F IN G I LD E T V+ ++
Sbjct: 1069 --VISAAAINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
Query: 2557 VMARD-------GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609
+ + + V I + DEN++PP F+ Y + + + V++V A
Sbjct: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
Query: 2610 YDADEGQNADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
D D G + + Y + P K+ + TG++K + F + A D
Sbjct: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
Score = 175 bits (444), Expect = 8e-43
Identities = 196/760 (25%), Positives = 321/760 (42%), Gaps = 94/760 (12%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V A
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV-A 433
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT-------TGVIR---LEKPLQVRPQAPLELTV 3187
D D D F D T TG+ R L +P+ Q ++
Sbjct: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 3188 RASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPG 3247
A D + S V + V+ D P F + V V D PG V+QL +
Sbjct: 494 TAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 550
Query: 3248 AE--KTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSD 3303
+ Y ++ G QG F ++ TG++ + ++ Y L+++ + + + +
Sbjct: 551 GSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
Query: 3304 VTTVMVNITDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIG 3362
+ TV + + N P +FPQ YS + E VG V+L + ATD +G ITY++
Sbjct: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIEN 666
Query: 3363 GNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDN 3422
G+ F + G L + KALDRE Y L + A+D G+P + I V DVNDN
Sbjct: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
Query: 3423 PPRF---FQLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
P F N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T
Sbjct: 726 APVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRIT 778
Query: 3479 PDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFI 3538
+G + TA L+R +++Y+L + A+D + P S ++ + V + +P +
Sbjct: 779 SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 838
Query: 3539 TVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
V E+ G + +I A D D ++Y + E +HF
Sbjct: 839 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV--KHF 876
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 766 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 886 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 944
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 945 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 1004
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 1005 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1061
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 1062 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1122 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1238
Score = 77.0 bits (188), Expect = 4e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 659 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 708
Query: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 768
Query: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 769 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 825
Query: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
S V T +TY TVLV+ N +G + +E D G
Sbjct: 826 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 870
Query: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 871 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 930
Query: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
+ P F +I + P + + V + PPG VR V +
Sbjct: 931 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 986
Query: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 987 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1037
Query: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 1038 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1093
Query: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 1094 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1152
Query: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 1153 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1212
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 1213 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1265
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 254 bits (650), Expect = 1e-66
Identities = 294/1160 (25%), Positives = 499/1160 (43%), Gaps = 160/1160 (13%)
Query: 2492 ENAMVGTKVIDLLAIDKDSG-PYGTI--------DYTIINKLASEKFSINPNGQIATLQK 2542
E + GT ++D + I +G P TI DY ++ + +N G++
Sbjct: 48 EESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRV----- 102
Query: 2543 LDRE---NSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVS 2599
LDR+ N V+ ++ + + G + + V+I++ D NDN P FK Y ++
Sbjct: 103 LDRDPPMNIHSIVVQVQCINKKVG-TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 2600 KDSPVIQVL-----AYDADEGQNADVTYSV--NPEDLVK-DVIEIN-PVTGVVKVKDSLV 2650
+ + A D D+G N + Y + NP+D D EI +TG + ++ L
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRL- 220
Query: 2651 GLENQTLDFFI-----KAQ--------------------DGGP--------PHWNSLVPV 2677
E++T F I +AQ D GP P+ P+
Sbjct: 221 NYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPL 280
Query: 2678 RLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKD 2737
Q ++ P+ P+ + + + I + + + ++YS++ GT + +
Sbjct: 281 TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI---QPPSDRPGILYSILVGTPEDYPR- 336
Query: 2738 GVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVF 2797
F + P T + + +P++ + + + + + A + + ++I++ D N+ P F
Sbjct: 337 -FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 2798 EADPYKAVLTENMPVG---------TSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELF 2848
Y+ + E+ PVG TS +++ A+DKD L + ++V +
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV- 454
Query: 2849 AIDSESG---WITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPR 2905
+++G ++T LQ +D E QTY F + A+D +Q S +V + + D NDN P
Sbjct: 455 ---TQTGITRYLTLLQPVDREEQQTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPT 508
Query: 2906 FASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ------ 2959
F Y V + PG+ V L +DAD N ++T I G G F I++
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDAD-EGSNGEITYEILVGAQ-GDFIINKTTGLIT 566
Query: 2960 --------VGDEWRISSR------------------KTLDREHTAKYLLRVTASDGKFQ- 2992
VG + ++ + K LDRE T +Y+L +TASDG+
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
Query: 2993 -ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLH 3051
++ TV I V DVNDN+P L + F+ +V ATD D N Q+ YSL
Sbjct: 627 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 685
Query: 3052 GPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDN 3109
G + F++ + G + T L+RE +D + LV ATDG + +TL ++ D++DN
Sbjct: 686 GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 744
Query: 3110 APRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVI 3169
+P F S V V +N T + + A+D D GAN P+ + F++ TG +
Sbjct: 745 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGEL 803
Query: 3170 RLEKPLQVRP----QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSV 3225
L + L +A + V A D+ +P + TVTV V + DY PVF +
Sbjct: 804 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKG 862
Query: 3226 QVPEDAPPGTEVLQLAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNAS 3278
V DA GT + + PG A + YRV F ++ +G + +
Sbjct: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
Query: 3279 LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVG 3337
L+ E + + L + +S TV + + E P+F Q+ Y V E A G
Sbjct: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKG 981
Query: 3338 DVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLR 3397
++ +SA +N I YS++ GN+ F I+ G + V LD E +SY L+++
Sbjct: 982 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
Query: 3398 ATDSGQ--------PPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLI 3449
A DS + P + I++ D N++PP F + Y V E++ + + VL++
Sbjct: 1038 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1096
Query: 3450 LSDPDSPENGPPYSFR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQAS 3504
+D D+ N ++R I +G G T G + TA + +++ Q+ A+
Sbjct: 1097 ATDKDT-GNYSVMAYRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIAT 1154
Query: 3505 DSGIPPLSSLTSVRVHVTEQ 3524
D LS V V V Q
Sbjct: 1155 DDYGKGLSGKADVLVSVVNQ 1174
Score = 251 bits (641), Expect = 1e-65
Identities = 283/1103 (25%), Positives = 461/1103 (41%), Gaps = 174/1103 (15%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
Query: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
Query: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
Query: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1179 GNYMGFFMIHPVTGLLSTA----------------------------------QQLDREN 1204
G G F+I+ TGL++ A + LDRE+
Sbjct: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRES 609
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP-- 1262
D +IL +T D G P ST+ V + + DVNDN P+ F+ LP LS V
Sbjct: 610 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV-----FDPYLPRNLSVVEEEANA 663
Query: 1263 -VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTA-------GEYNIL 1314
V ++ A+D D G+NG+V YS+ + + + + S+ S +TA +Y L
Sbjct: 664 FVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSNGSIYTAVKLNREVRDYYEL 716
Query: 1315 TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE 1374
+ ATD P +++ L I+ + S + F + Y+ V E P ++ +E
Sbjct: 717 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEENLPAG--TTILQIE 771
Query: 1375 GRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR----RRSNYNLTVEVTD-- 1424
+ N+S + + F + TG + + R LD + ++ VE D
Sbjct: 772 AKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 831
Query: 1425 GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQD----KGKS 1480
G+ ++ ++N + P F + Y+ V D V G + V A D D
Sbjct: 832 GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASR 891
Query: 1481 LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVMVRDQEIPIKRNFV 1539
+ Y + Q P AS+F+++ SG ++T +++L P+ L V+ D P+ +
Sbjct: 892 VRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
Query: 1540 WVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
V I V LHP PRFTQ Y +A ++ V + A +N + YS++
Sbjct: 950 TVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVS 1002
Query: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE-------DQGSPQWHDLATVIIH 1649
GN E F IN + G+I + LD + L V+A+ + P + A V I
Sbjct: 1003 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1062
Query: 1650 VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE----------LREGNK 1699
+ + P+F K Y + E + + +L V A Y ++EG K
Sbjct: 1063 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG-K 1121
Query: 1700 DGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNMAGAFTDVMVVVDIIDEN-- 1752
+G F + +Y+GLI T + + S ++ ++ G ++G ++ VV+ +D
Sbjct: 1122 EG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1180
Query: 1753 -DNAPMFLKSTFVGQISEAAPLY 1774
N P L + ++E Y
Sbjct: 1181 VSNVPPTLVEKKIEDLTEILDRY 1203
Score = 236 bits (603), Expect = 3e-61
Identities = 287/1075 (26%), Positives = 451/1075 (41%), Gaps = 151/1075 (14%)
Query: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLS-- 2887
G+++Y + + F I+ +G IT ++ +TY V A D+ + S
Sbjct: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
Query: 2888 ------------------------------SQALVQVSITDENDNAPRFASEEYRGSVVE 2917
S A V + +TD NDNAP F R V
Sbjct: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
Query: 2918 NSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHT 2977
E V +K D D N QV + + G+ F I+ G I + L+RE
Sbjct: 658 EEEANAFVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVR 711
Query: 2978 AKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVS 3034
Y L V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++
Sbjct: 712 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 771
Query: 3035 ATDLDTDTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATD 3089
A D+D N ++Y + P H F L P TGEL+ L +LD E ++ + +A D
Sbjct: 772 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
Query: 3090 GGGRSCQ--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--N 3145
G A +T+ V+D+ND P F V + TP+ V+A D D
Sbjct: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
Query: 3146 AQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTL 3201
++V Y + D + F ++ +G + L P +L V A D G P+ +S+
Sbjct: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSS 948
Query: 3202 GTVTVSVVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSG 3258
TV + V+ + +P F E+ V E A GT V + A + + Y +VSG
Sbjct: 949 ATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSG 1003
Query: 3259 NEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNI 3311
NE+ F ++ TG++YVN LD+ET Y L ++ + S S+ V + I
Sbjct: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
Query: 3312 TDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQL 3366
D N H P F + Y V E+A + +L V ATD+D S + Y LI G +
Sbjct: 1064 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE- 1122
Query: 3367 GHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
F + G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 1123 -GFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 230 bits (586), Expect = 3e-59
Identities = 244/899 (27%), Positives = 400/899 (44%), Gaps = 113/899 (12%)
Query: 406 FKLNARTGLITTTKLM--DFHDRAHYQLHIRTSPGQ---ASTVVVIDIVDCNNHAPLFNR 460
F ++ RT ++ + + DFH + + G A + I+I+D NN +P F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 461 SSYDGTLDENIPPG---------TSVLAVTATDRDHGE----------NGYVTYSIAGPK 501
SY G + E+ P G TS L + A D+D + N Y +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
I YL ++ +P+D E ++ YTF + A D + + V + +Q+ + NDN
Sbjct: 458 G----ITRYLTLL---QPVDRE-EQQTYTFSITAFDG---VQESEPVIVNIQVMDANDNT 506
Query: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
P F E++ + D G S++ ++A+D DE N + YEI+ G + ++ +N +G+I
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLI 565
Query: 620 SLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQF 679
++ P + + G+ +Y+L + A+D A +T +T+ K E + D+
Sbjct: 566 TIA-PGVEMIVGR--TYALTVQAADNAPPAERSTGILTLGKALDRE---STDR------- 612
Query: 680 TKTILHFIGLQNQESSDEEFTSLSTYQI-----NHYTPQFEDHFPQSIDVLESVPINTPL 734
+I + + TS +T I N P F+ + P+++ V+E N +
Sbjct: 613 ------YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFV 665
Query: 735 ARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
++ ATDPDAG NG++ Y + GN F I G + A L+ E ++Y L V D
Sbjct: 666 GQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATD 722
Query: 795 LGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGR 854
+ S L + V D +DN+P F Y + + E+ GTTI ++ KD D N
Sbjct: 723 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN-- 780
Query: 855 VRYTLLSPTEK--FSLHPLTGELVVTGHLDRES----EPRYILKVEARDQPSKGHQLFSV 908
V Y + SP K F+LHP TGEL + LD E+ E VEA D G +
Sbjct: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGI 838
Query: 909 TDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT--FLDASDPDLGPAGEVRYVLMD 966
+ + ++D+ND P + V D GT +T + + +DP PA VRY + D
Sbjct: 839 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 898
Query: 967 GAH----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLD 1022
F V+ +G +I L+ E + L + A D G P+ + V+++V
Sbjct: 899 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV-- 955
Query: 1023 VNENLHPPHFASFVHQ----GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLA 1078
LHP F + V E + GT V V++A + ++ + Y + +G
Sbjct: 956 ----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
Query: 1079 AFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--------SSVTEVYIEVTDA 1130
F IN TG+I PLD E + Y L V A D V L S+ +VYIE+ D
Sbjct: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
Query: 1131 NDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-----ITSGNYMGFF 1185
N++PP + + + EDA + TSVL++ A D D+ + + + I G F
Sbjct: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGF 1124
Query: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
++ TGL+ TA + +V D+ L + V+V +++ D I S+
Sbjct: 1125 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
Score = 228 bits (581), Expect = 1e-58
Identities = 288/1128 (25%), Positives = 481/1128 (42%), Gaps = 166/1128 (14%)
Query: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAV 1916
+V I VRD ND+ P F + Y + +E + V +I TG + +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATV----------------NELTPVGTTIFTGFSGD-- 173
Query: 1917 TIHPVTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQ--VLDKSLQF-DQDVY 1973
G+ + + + + D DT + + LT VL K L + D+ Y
Sbjct: 174 -----NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 228
Query: 1974 WAAVK-----ENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHM-VQSAGVLQTRGVA 2027
+ ++ +NL +R+ TL+ +L+G D+ M + V TR
Sbjct: 229 FVIIQANDRAQNLNERRT----------TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC- 277
Query: 2028 FDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI----EDVNDNPPKFKHLPYYTIIQDGT 2083
+ T++ A+ + RTP+ + +V I +D N PP + Y+I+
Sbjct: 278 ----RPLTYQAAIP--ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSIL---- 327
Query: 2084 EPGDVLFQVSATDEDLGTNGAVTYEFAEDY-TYFRIDPYLGDISLKKPFDYQALNKYHLK 2142
+GT EDY +F + P ++SL +P + K+ L
Sbjct: 328 ---------------VGT--------PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
Query: 2143 VIA-RDGGTP-SLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHT-QARSPE 2199
+ A +D G P + + + N +P F P Y+ + E+ + I + SP
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2200 GLRLIYNIVE---EEPLMLFTTDF-------KTGV---LTVTGPLDYESKTKHVFTVRAT 2246
+ + +E + L LF D+ +TG+ LT+ P+D E + + F++ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2247 DTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRD 2306
D S V + V D NDN PTF ++ Y + + VIQL A D D G N +
Sbjct: 485 DGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 2307 VSYQIVEDGSD--------------------VSKFFQI-----------NGSTGEMSTVQ 2335
++Y+I+ V + + + STG ++ +
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
Query: 2336 ELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSEL-ATC 2394
LD E+ + + + A D G P T V + V+D+NDN P F P N+S +
Sbjct: 604 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEA 661
Query: 2395 GHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRV 2454
V +V+A DPD+ ++ Y + GN + F I S+ I + L + + Y L V
Sbjct: 662 NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKL-NREVRDYYELVV 718
Query: 2455 GASDGVF---RATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG 2511
A+DG +T+ + I + + SP F Y + EN GT ++ + A D D G
Sbjct: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
Query: 2512 PYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRE--NSTERVIAIKVMARDGGGRV-- 2566
+ Y I + F+++P G+++ L+ LD E E I V A D G +
Sbjct: 779 --ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
Query: 2567 AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDAD-EGQNAD-VTYSV 2624
TV +I+ D ND PP F Y + + K +P+ V A DAD G A V Y V
Sbjct: 837 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
Query: 2625 NPEDL--VKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVV 2682
+ + E+ +G V + +L + A D G P +S V++ V+
Sbjct: 897 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 956
Query: 2683 PKKVSLPKFSEPLYTFSAPEDL-PEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFS 2741
+P+F++ Y +L +G+ +G++ A A ++YS+V G N++ F
Sbjct: 957 -HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSG-----NEEDTFG 1010
Query: 2742 LDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ----NTDVVS---LVSVNIQVGDVNDNR 2794
++ TGVI V P+D+E+ Y + V A L+ N V S V I++ D N++
Sbjct: 1011 INNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
Query: 2795 PVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSES 2854
PVF+ Y ++E+ + TSV++V A DKDTG ++YRL P E F +++ +
Sbjct: 1071 PVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYT 1130
Query: 2855 GWITTLQELDCETCQTYHFHVVAY-DHGQTIQLSSQALVQVSITDEND 2901
G I T + F V+A D+G+ LS +A V VS+ ++ D
Sbjct: 1131 GLIKTAMLFHNMRRSYFKFQVIATDDYGK--GLSGKADVLVSVVNQLD 1176
Score = 222 bits (565), Expect = 7e-57
Identities = 253/1000 (25%), Positives = 427/1000 (42%), Gaps = 124/1000 (12%)
Query: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLM-- 965
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 966 ---DGAHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPL--ARRTLCHVEVI 1019
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1020 VLDVNENLHPPHF-----------ASFVHQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
VLD ++L P +Q + E +P I+V A D D +
Sbjct: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
Query: 1064 DGE-----LQYFLRAGTG---LAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
Query: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
Query: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRP 1342
+ F I+ TG+++ + G LT++A D+ PP S + R
Sbjct: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA-PPAERSTGILTLGKALDRE 608
Query: 1343 SS-----IPLAFD-----ETYYSFTVMETDPVNHMVGVIS---------VEGRPGLFWFN 1383
S+ I A D + + ++ TD VN V VE F
Sbjct: 609 STDRYILIITASDGRPDGTSTATVNIVVTD-VNDNAPVFDPYLPRNLSVVEEEANAFVGQ 667
Query: 1384 ISGGDKDMDFDIE--------------KTTGSIVIARPLDTRRRSNYNLTVEVTDGS--R 1427
+ D D + + + GSI A L+ R Y L V TDG+
Sbjct: 668 VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 727
Query: 1428 TIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHG 1487
+T + +I+ + P F + Y V V ++ G +L+++A D D G ++ Y I
Sbjct: 728 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI-- 785
Query: 1488 SQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTVMVRDQEI--PIKRNFVWVTIH 1544
+ P F L P +G L + LD + P Q ++T +V +I + VT+
Sbjct: 786 -RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 844
Query: 1545 VEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD-RGVNA-EVHY---SLLKGNS 1599
V+D N +PP F++ Y+ V GT + V A DAD G+ A V Y +
Sbjct: 845 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 904
Query: 1600 EGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATV-IIHVYPSDRSAP 1658
F + G + L++ L V A D G P ATV I+ ++P + P
Sbjct: 905 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE--IP 962
Query: 1659 IFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELREGNKDGVFSMNSYSGLISTQK 1716
F++ EY + E G+ + ++SA + ++ + Y + GN++ F +N+ +G+I
Sbjct: 963 RFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1022
Query: 1717 KLDHEKISSYQLKIRGSNMAGAFTDV---------MVVVDIIDENDNAPMFLKSTFVGQI 1767
LD+E +SY L+++ ++ ++ V ++I DEN++ P+F K ++G +
Sbjct: 1023 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1082
Query: 1768 SEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEP 1807
SE A +++ ++ + A+D D S++ Y+++ P
Sbjct: 1083 SEDARMFTSVLR-------VKATDKDTGNYSVMAYRLIIP 1115
Score = 219 bits (559), Expect = 4e-56
Identities = 271/1066 (25%), Positives = 437/1066 (40%), Gaps = 144/1066 (13%)
Query: 2156 EEEVLVTVRNKSNPLFQSPYYKVRV----PENITLYTPILHTQARS-----PEG-LRLIY 2205
E ++V RN ++P F+ Y V P T++T + P G + +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2206 NIVEEEPLMLFTTDFK---TGVLTVTGPLDYESKTKHVFTVRATDTALG----SFSEATV 2258
++P T + TG + + L+YE KT++ ++A D A + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2259 EVLVEDVNDNPPTF------------SQLVYTTSISEGLPAQ-------TPVIQLLASDQ 2299
V V D +D P F L Y +I E + TP IQ + D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2300 DSGRNRD---VSYQI-VEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKG 2355
+ D + Y I V D +FF ++ T E+S ++ ++ + Q F + ++A
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2356 DPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLV---------LKVQAIDP 2406
PL + + + D N+ P F P Y+ + E A G + L++ A+D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 2407 DSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK---KHLDSSYNLRVGASDGVFRA 2463
D DT E L L N F + +GI L + + +Y + A DGV +
Sbjct: 432 DIEDTKDPE-LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-QE 489
Query: 2464 TVPVYIN--TTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTII 2521
+ PV +N +AN +P F + Y+ + + G VI L A+D D G G I Y I+
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2522 NKLASEKFSINPNGQIATL-----------------------------------QKLDRE 2546
A F IN + T+ + LDRE
Sbjct: 550 VG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRE 608
Query: 2547 NSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSP-- 2603
ST+R I I + A DG + TV I++TD NDN P F Y S V +++
Sbjct: 609 -STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF 664
Query: 2604 VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFF--- 2660
V QV A D D G N V YS+ + + + + VK L + D++
Sbjct: 665 VGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK-------LNREVRDYYELV 717
Query: 2661 IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD 2720
+ A DG +S + + ++V+ + P F+ YT E+LP G+ I + A+D
Sbjct: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI---LQIEAKD 774
Query: 2721 PVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID----VMAHCLQNTD 2776
+ + V F+L P TG + + + +D+E+ + V A + T
Sbjct: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 834
Query: 2777 VVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTG--RDGQVSY 2834
+ +V + V D+ND PVF YK ++ + GT + V A D D +V Y
Sbjct: 835 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
Query: 2835 RLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQV 2894
R+ +F ++ +SG + T L+ E + VVA+D G+ + +SS A V++
Sbjct: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKI 953
Query: 2895 SITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLG 2953
+ + PRF EEYR V E + G +V + + N+ + I G+
Sbjct: 954 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVYSIVSGNEED 1007
Query: 2954 QFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF----------QASVTVEIFVLD 3003
FGI+ + ++ LD E Y+LRV A + + V I + D
Sbjct: 1008 TFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1065
Query: 3004 VNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGP----GAHEFK 3059
N++ P + Y G V ED +L+V ATD DT + + Y L P G F
Sbjct: 1066 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV 1125
Query: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQADITLHV 3103
++ +TG + T R+ F ATD G G S +AD+ + V
Sbjct: 1126 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
Score = 209 bits (531), Expect = 6e-53
Identities = 272/1090 (24%), Positives = 445/1090 (40%), Gaps = 130/1090 (11%)
Query: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
Query: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQINGS-TGEMSTVQELDYEAQQHFHVKVRA 2351
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
Query: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
Query: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
Query: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
Query: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
Query: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
Query: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 2669 PHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ--------D 2720
P S + L + S ++ + +A + P+G+ V V D
Sbjct: 591 PAERSTGILTLGKALDRESTDRY---ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 647
Query: 2721 PVIYSLVRGTTPESNK--DGVFSLDPDTGV----------------------IKVRKPMD 2756
P + + E+N V + DPD G+ I ++
Sbjct: 648 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLN 707
Query: 2757 HESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
E Y++ V+A S +++ I+V D++DN PVF Y ++ EN+P GT++
Sbjct: 708 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 767
Query: 2817 IQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETC----QTYH 2872
+Q+ A D D G VSYR+ + V FA+ +G ++ L+ LD E +
Sbjct: 768 LQIEAKDVDLG--ANVSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 822
Query: 2873 FHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD 2932
F V A+D T+ A V V + D ND P F+ Y+G V ++ G + T+ D
Sbjct: 823 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 881
Query: 2933 AD----ISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTA-S 2987
AD + + R + P F + + D R+ +R L+ E T + L V A
Sbjct: 882 ADPPGLPASRVRYRVDDVQFPYPASIFEVEE--DSGRVITRVNLNEEPTTIFKLVVVAFD 939
Query: 2988 DGK--FQASVTVEIFVLDVNDNSPQCSQLLY-TGKVHEDVFPGHFILKVSATDLDTDTNA 3044
DG+ +S TV+I VL + P+ +Q Y V E G + +SA + N
Sbjct: 940 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI----NQ 994
Query: 3045 QITYSL-HGPGAHEFKLDPHTGELTTLTALDRERK---------DVFNLVAKATDGGGRS 3094
I YS+ G F ++ TG + LD E + D +V +S
Sbjct: 995 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
Query: 3095 CQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-- 3152
A + + ++D N++ P F V ++ + T V V A D D G + + Y L
Sbjct: 1055 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1114
Query: 3153 PDSAEGH--FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVG 3210
P EG F ++ TG+I+ ++ + V A+D LS V VSVV
Sbjct: 1115 PPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSVVN 1173
Query: 3211 LEDYLPVFLN 3220
D + N
Sbjct: 1174 QLDMQVIVSN 1183
Score = 196 bits (498), Expect = 4e-49
Identities = 230/904 (25%), Positives = 379/904 (41%), Gaps = 103/904 (11%)
Query: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQ---NTDVVSLVSVNIQVGDVNDNRPVF----- 2797
TG I +RK +++E Y + + A+ N + ++ + V D +D P+F
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2798 -----EADP--YKAVLTE-NMPVGTSVIQVT----AIDKD------TGRDGQVSYRLSAD 2839
+ P Y+A + E P + I VT AID+D + R G + Y +
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVG 329
Query: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVA-YDHGQTIQLSSQALVQVSITD 2898
+ F + + ++ L+ ++ + Q + + A D+G L + A + + I D
Sbjct: 330 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD 387
Query: 2899 ENDNAPRFASEEYRGSVVENSEPGELVAT---------LKTLDADISEQNRQVTCYITEG 2949
EN+ +P F Y+G ++E++ G ++ + LD DI E + ++
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI-EDTKDPELHLFLN 446
Query: 2950 DPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQAS-VTVEIFVLDVNDNS 3008
D F ++Q G ++ + +DRE Y +TA DG ++ V V I V+D NDN+
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 3009 PQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELT 3068
P ++ Y V+ D+ PG +++++A D D +N +ITY + +F ++ TG +T
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
Query: 3069 -------------TLT---------------------ALDRERKDVFNLVAKATDGG-GR 3093
LT ALDRE D + L+ A+DG
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
Query: 3094 SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLP 3153
+ A + + V DVNDNAP F P V V A DPD G N QV YSL
Sbjct: 627 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 685
Query: 3154 DSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLED 3213
+ F I + G I L + EL V A+D G P + T+ + V+ ++D
Sbjct: 686 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDD 743
Query: 3214 YLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGIL 3273
PVF N+ ++V V E+ P GT +LQ+ YR+ S + F L TG L
Sbjct: 744 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGEL 803
Query: 3274 YVNASLDFETSPKYFLSI----ECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR 3329
+ SLD+E P SI E + + TV V + D+N++ P F + Y
Sbjct: 804 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGM 863
Query: 3330 VLENALVGDVILTVSATDEDGP-LNSDITYSLIGGNQLGH----FTIHPKKGELQVAKAL 3384
V +A+ G I TV A D D P L + + Q + F + G + L
Sbjct: 864 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 923
Query: 3385 DREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNY-STTVQENSPIGS 3443
+ E + + L + A D G+P + + I V + PRF Q Y V E + G+
Sbjct: 924 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGT 982
Query: 3444 KVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEG-LSRRAQEWYQLQIQ 3502
V + + + I GN F + ++ G L + Y L++Q
Sbjct: 983 MVGVI-----SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
Query: 3503 A-------SDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHA 3555
A ++ +P S+ V + + +++++ P V ED V ++ A
Sbjct: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
Query: 3556 TDRD 3559
TD+D
Sbjct: 1098 TDKD 1101
Score = 194 bits (494), Expect = 1e-48
Identities = 289/1215 (23%), Positives = 493/1215 (40%), Gaps = 189/1215 (15%)
Query: 1099 FASYYWLTVLAVDRGSVPLSSVTEVYIEVTD-----ANDNPPQMSQAVFYPSIQEDAPVG 1153
F +Y T LA + L S+ E+ + D A PP A+ S V
Sbjct: 2 FRQFYLWTCLA---SGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVD 58
Query: 1154 TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLL---STAQQLDRE---NKDE 1207
+++ A PD + + L N+ + ++ PV +L ST + LDR+ N
Sbjct: 59 NMLIKGTAGGPDPTIELSLKDNVDY-----WVLMDPVKQMLFLNSTGRVLDRDPPMNIHS 113
Query: 1208 HILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP----GPV 1263
+++V + N + V + + D NDN P F H+ + + E L+PV G
Sbjct: 114 IVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFS 171
Query: 1264 YRLVASDLDEGLNGRVTYSIEDSDEEAFSID------LVTG--VVSSSSTFTAGEYNILT 1315
A+D+D+G NG++ Y I+ + ++ S D ++TG V+ + +
Sbjct: 172 GDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI 231
Query: 1316 IKATDSGQ---------PPLSASVRLHIEWIPWPRPSSI--------PLAFDETYYSF-T 1357
I+A D Q L+ V + P P + PL + T
Sbjct: 232 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 291
Query: 1358 VMETDPVNHMVGVISVE---------GRPGLFWFNISGGDKDMD--FDIEKTTGSIVIAR 1406
E +P+ + +++ RPG+ + + G +D F + T + +
Sbjct: 292 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 351
Query: 1407 PLDTRRRSNYNLTVEVT-DGSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPG 1464
P++ ++L ++ D + + + I + N+ P F Y+ + + G
Sbjct: 352 PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 411
Query: 1465 VEL---------LRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVT------- 1508
+ LR+ A+D+D I ++DP LF D +S VT
Sbjct: 412 ATISDSLNLTSPLRIVALDKD--------IEDTKDP-ELHLFLNDYTSVFTVTQTGITRY 462
Query: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
+ L Q T T + + + V V I V D N + P F ++ Y+ V +
Sbjct: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTL 1628
PG ++Q+ A+DAD G N E+ Y +L G ++G F IN G+IT+A ++ + L
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
Query: 1629 TVKAEDQ---------------------------------GSPQWHDLATVIIHVYPSDR 1655
TV+A D G P ATV I V +
Sbjct: 582 TVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVND 641
Query: 1656 SAPIFS----KSEYFVEIPESIPVGSPILLVSAMSPS-----EVTYELREGNKDGVFSMN 1706
+AP+F ++ VE + VG V A P +V Y L GN + +F +
Sbjct: 642 NAPVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRIT 695
Query: 1707 SYSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFV 1764
S +G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 696 S-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 754
Query: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI 1824
+ E P + I+ I A D D AN + Y+I PE FF + P G L++
Sbjct: 755 VLVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 805
Query: 1825 VSEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVA 1880
+ +DYE+ P S F V D + P A V + V+D+ND PP FS++IY+
Sbjct: 806 LRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGM 863
Query: 1881 IVGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---L 1928
+ G + V A D D S V Y + +I V +G + L
Sbjct: 864 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 923
Query: 1929 NPAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKA 1986
N + + + + DG + +A VKI + + +F Q+ Y L +
Sbjct: 924 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP-GEIPRFTQEEYRPPPVSELATKGT 982
Query: 1987 LV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE-- 2041
+V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 983 MVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQAD 1039
Query: 2042 -----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ + R P + V + I+D N++PP F+ Y + + + +V ATD
Sbjct: 1040 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1099
Query: 2097 EDLGTNGAVTYEFA-----EDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP 2151
+D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 1100 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1159
Query: 2152 SLQSEEEVLVTVRNK 2166
L + +VLV+V N+
Sbjct: 1160 GLSGKADVLVSVVNQ 1174
Score = 186 bits (472), Expect = 4e-46
Identities = 245/1038 (23%), Positives = 421/1038 (40%), Gaps = 135/1038 (13%)
Query: 1541 VTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELL-----QVRAMDADRGVNAEVHYSLL 1595
V I V D N + P F Y A+V + GT + A D D G N ++ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1596 KG----NSEGFFNINALL-GIITLAQKLDQANHAPHTLTVKAEDQG---SPQWHDLATVI 1647
S F I +L G I L ++L+ + + + ++A D+ + + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1648 IHVYPSDRSAPIFSKS------------EYFVEIPE--------SIPVGSPILLV----S 1683
+ V D P+F Y IPE I V PI + +
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1684 AMSPSE---VTYELREGNKDGV---FSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG 1737
PS+ + Y + G + F M+ + +S + ++ + + L I+ G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1738 ----AFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNN--NPFVIHASD 1791
AF + + +I+DEN+ +P F ++ G I E+AP+ + I D N +P I A D
Sbjct: 373 HPLPAFAGLHI--EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1792 SDKEANSLLVYKILEPEALKFFKIDPSMGT--LTIVSEMDYESMPSFQFCVYVHDQGSPV 1849
D E + + F + + T LT++ +D E ++ F + D
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---- 486
Query: 1850 LFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDS----EVNY 1905
+ P V I V D ND+ P F E Y+V + + PG ++ + A D D E+ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1906 SIKTGNADEAVTIHPVTGSISVLNPA--FLGLSRKLTIRASDGLYQ-------------- 1949
I G + + I+ TG I++ +G + LT++A+D
Sbjct: 547 EILVGAQGDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKAL 605
Query: 1950 ----------------------DTALVKISLTQVLDKSLQFDQDV--YWAAVKENLQDRK 1985
TA V I +T V D + FD + + V+E
Sbjct: 606 DRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 665
Query: 1986 ALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDN 2045
V +N + Y L N ++F + + + V +RE +D +EL V D
Sbjct: 666 GQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA--VKLNREVRDYYELVVVATDG 723
Query: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105
R + + + + D++DN P F + Y ++++ G + Q+ A D DLG N +
Sbjct: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY 783
Query: 2106 TYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVI----ARD--GGTPSLQSEEEV 2159
E +F + P+ G++SL + DY+A + A D G P + V
Sbjct: 784 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 843
Query: 2160 LVTVRNKSNPLFQSPYYKVRVPENITLYTPI--LHTQARSPEGL---RLIYNIVEEE--- 2211
+V N P+F YK V + TPI ++ + P GL R+ Y + + +
Sbjct: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 903
Query: 2212 PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSF-SEATVEVLVEDVNDNPP 2270
P +F + +G + L+ E T V A D S ATV++LV + P
Sbjct: 904 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 962
Query: 2271 TFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGE 2330
F+Q Y L + ++ ++++ + N+ + Y IV + + F IN TG
Sbjct: 963 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDT--FGINNITGV 1017
Query: 2331 MSTVQELDYEAQQHFHVKVRA-------MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ 2383
+ LDYE + + ++V+A + P + V + + D N++PP F++
Sbjct: 1018 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1077
Query: 2384 YEANVSELATCGHLVLKVQAIDPDSRDTSRLEY-LILSGNQD--RHFFINSSSGIISMFN 2440
Y VSE A VL+V+A D D+ + S + Y LI+ ++ F + + +G+I
Sbjct: 1078 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAM 1137
Query: 2441 LCKKHLDSSYNLRVGASD 2458
L S + +V A+D
Sbjct: 1138 LFHNMRRSYFKFQVIATD 1155
Score = 182 bits (462), Expect = 6e-45
Identities = 266/1078 (24%), Positives = 434/1078 (40%), Gaps = 182/1078 (16%)
Query: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
Query: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
Query: 815 DNAPRFPPG------------GYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
D P F P YQ I E E+ I + D + D
Sbjct: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
Query: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
Query: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
L I + D N+ SP + + E P G ++ D
Sbjct: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
Query: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
Query: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 488 QESEPVIVNIQVMDANDNT--PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 1069 YFLRAGTGLAAFSINQDTGMIQTLAP---------------------------------- 1094
Y + G F IN+ TG+I T+AP
Sbjct: 546 YEILVGAQ-GDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
Query: 1095 -LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPV- 1152
LDRE Y L + A D G +S V I VTD NDN P VF P + + V
Sbjct: 604 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-----VFDPYLPRNLSVV 657
Query: 1153 ----GTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH 1208
V Q+ A DPD+ G++ +++ GN+ F I G + TA +L+RE +D +
Sbjct: 658 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYY 714
Query: 1209 ILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVA 1268
L V D ST + + +LD++DN P+F++ + V + E L + + ++ A
Sbjct: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP--AGTTILQIEA 772
Query: 1269 SDLDEGLNGRVTYSIEDSD-EEAFSIDLVTGVVS-----SSSTFTAGEYNI-LTIKATD- 1320
D+D G N V+Y I + + F++ TG +S F E +I ++A D
Sbjct: 773 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 830
Query: 1321 -SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR--P 1377
PP A+V + ++ + + P F + Y V + + E P
Sbjct: 831 YGTMPPGIATVTVIVKDM-----NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 885
Query: 1378 GLFWFNISGGDKDMD-------FDIEKTTGSIVIARPLDTRRRSNYNL-TVEVTDGSRTI 1429
GL + D+ F++E+ +G ++ L+ + + L V DG +
Sbjct: 886 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 945
Query: 1430 ATQVHIFMIANINHHRPQFLETRYEVRVP-------QDTVPGVELLRVQAIDQDKGKSLI 1482
++ + ++ P+F T+ E R P + T+ GV + AI+Q S++
Sbjct: 946 SSSATVKILVLHPGEIPRF--TQEEYRPPPVSELATKGTMVGV--ISAAAINQ----SIV 997
Query: 1483 YTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS------QHTLTVMVRDQEIPIKR 1536
Y+I + + F ++ +GV+ G LD + S +L V++ + +P K
Sbjct: 998 YSIVSGNEEDT---FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
Query: 1537 NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL-- 1594
N V I ++D N HPP F + Y V + T +L+V+A D D G + + Y L
Sbjct: 1055 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1114
Query: 1595 --LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHV 1650
+K EGF + G+I A + V A D A V++ V
Sbjct: 1115 PPIKEGKEGFV-VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
Score = 155 bits (393), Expect = 6e-37
Identities = 196/774 (25%), Positives = 302/774 (39%), Gaps = 127/774 (16%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
Query: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 3254 RVVSGNEQGRFRL----------------------------------DARTGILYVNASL 3279
++ G QG F + + TGIL + +L
Sbjct: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKAL 605
Query: 3280 DFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLE------N 3333
D E++ +Y L I S S TV + +TDVN++ P F DPY R L N
Sbjct: 606 DRESTDRYILIITASDGRPDGTS-TATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEAN 662
Query: 3334 ALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYS 3393
A VG V ATD D +N + YSL N L T G + A L+RE Y
Sbjct: 663 AFVGQV----KATDPDAGINGQVHYSLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYE 715
Query: 3394 LKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDP 3453
L + ATD P H +AI+V D++DN P F Y+ V+EN P G+ +LQ+ D
Sbjct: 716 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 775
Query: 3454 DSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRA----QEWYQLQIQASD--S 3506
D G S+RI F + P G L L A + ++A D
Sbjct: 776 DL---GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 832
Query: 3507 GIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
+PP + +V V V + + Y P V D +G + ++A D DP
Sbjct: 833 TMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
Score = 153 bits (386), Expect = 4e-36
Identities = 251/1137 (22%), Positives = 427/1137 (37%), Gaps = 191/1137 (16%)
Query: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
Query: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
Query: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
A DR + ++E G+ G + V V P LR P
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
Query: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
Query: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
E SL ++ +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 346 ELSL--LEPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 369 VQLSEFSPPGSRV-------VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP---ELHLFLNDYTSVFTVTQTG 458
Query: 421 ----------MDFHDRAHYQLHIRTSPG---QASTVVVIDIVDCNNHAPLFNRSSYDGTL 467
+D ++ Y I G +V I ++D N++ P F SYD +
Sbjct: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
Query: 528 IYTFRVRASDWGSPFRREKEV--------------------------------SIFLQLR 555
Y V+A+D P R + ++ + +
Sbjct: 578 TYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 637
Query: 556 NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHF 615
++NDN P+F+ + + + A D D N + GN F +
Sbjct: 638 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 697
Query: 616 SGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGV 675
+ + + L Y L + A+DG + +TL + + +V D + V
Sbjct: 698 GSIYTA----VKLNREVRDYYELVVVATDGAVHPRHSTLTLAI------KVLDIDDNSPV 747
Query: 676 LTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLA 735
T T T+L V E++P T +
Sbjct: 748 FTNSTYTVL---------------------------------------VEENLPAGTTIL 768
Query: 736 RLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVT---- 791
++ A D D G N + Y I + F + TG L++ LDYEA ++T
Sbjct: 769 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
Query: 792 VYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSE- 850
+D+ +TV VKD ND P F Y+ ++ D GT I + +DAD
Sbjct: 827 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 886
Query: 851 -DNGRVRYTLLS-----PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQ 904
RVRY + P F + +G ++ +L+ E + L V A D G
Sbjct: 887 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---GEP 943
Query: 905 LFSVTDLIITLEDVNDNSPQCITEHNR-LKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV 963
+ S + + L P+ E R V E GT++ + A+ + + Y
Sbjct: 944 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYS 999
Query: 964 LMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCH----VEV 1018
++ G TF ++ +TG + + LD+E R Y L + A LA + +V
Sbjct: 1000 IVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1059
Query: 1019 IVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFL---RAGT 1075
+ +EN HPP F + G V E++ T V+ V A D D+G + Y L
Sbjct: 1060 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1119
Query: 1076 GLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDAND 1132
G F + TG+I+T SY+ V+A D LS +V + V + D
Sbjct: 1120 GKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 136 bits (342), Expect = 5e-31
Identities = 205/939 (21%), Positives = 372/939 (39%), Gaps = 195/939 (20%)
Query: 94 FLRIRTKSSNTALL---NREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDLKPLFS 149
F + +++ +LL NR+ + L+I+A + L A + + ILD+N+ P F+
Sbjct: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
Query: 150 PPSYR----------VTISEDMPLKSPICKVTATDADL--GQNAEFYYAFNTRSEMFAIH 197
PSY+ TIS+ + L SP+ ++ A D D+ ++ E + N + +F +
Sbjct: 397 MPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT 455
Query: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIA 257
T G+ L R + + ++ + E P I
Sbjct: 456 QT-GITRYLTLLQPVDREEQQTYTFSITAFDGVQESE-------------------PVIV 495
Query: 258 SVVVTPPDSNDGT------TYATVLVDANSSGAEVESVEVVGGDPGKHFK--------AI 303
++ V D+ND T +Y + G V + V D G + + A
Sbjct: 496 NIQVM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFE 363
+ + L+++ M + L++QA + P + G L +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP--AERSTGILTLGKALDRESTD 611
Query: 364 KAVYRVQLSEFSPPGSRVVMVRV--------TPAFP-----NLQYVLKPSSENVG----- 405
+ + + S+ P G+ V + P F NL V + ++ VG
Sbjct: 612 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 671
Query: 406 --------------------FKLNARTGLITTTKLMDFHDRAHYQLHI-----RTSPGQA 440
F++ + + T KL + R +Y+L + P +
Sbjct: 672 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHS 730
Query: 441 STVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGP 500
+ + I ++D ++++P+F S+Y ++EN+P GT++L + A D D G N V+Y I P
Sbjct: 731 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 788
Query: 501 KALP-FSIDPYLGIISTSKPMDYEL---MKRIYTFRVRASD-WGSPFRREKEVSIFLQLR 555
+ F++ P+ G +S + +DYE + TF V A D +G+ V++ ++
Sbjct: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VK 846
Query: 556 NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD----ELQNLKYEIVSGNELEY-- 609
++ND P+F + G + D G I T+ A D D ++Y + +++++
Sbjct: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY 903
Query: 610 ----FDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKN--YASPTTLNITVVKDPH 663
F++ SG + + +NL T + L + A D +S T+ I V+
Sbjct: 904 PASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---- 956
Query: 664 FEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSID 723
G + +FT+ E++ P +
Sbjct: 957 --------HPGEIPRFTQ---------------------------------EEYRPPPVS 975
Query: 724 VLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEAT 783
L + T + ++A A N +VY I GNEE F I TG++ V PLDYE
Sbjct: 976 ELATK--GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETR 1029
Query: 784 NFYI-------LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVG 836
Y+ L V + +L P KS+ + + ++D N++ P F Y +SED +
Sbjct: 1030 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1089
Query: 837 TTIAELTTKDADSEDNGRVRYTLLSP-----TEKFSLHPLTGELVVTGHLDRESEPRYI- 890
T++ + D D+ + + Y L+ P E F + TG L+ T L Y
Sbjct: 1090 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFK 1148
Query: 891 LKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH 929
+V A D KG L D+++++ VN Q I +
Sbjct: 1149 FQVIATDDYGKG--LSGKADVLVSV--VNQLDMQVIVSN 1183
Score = 134 bits (338), Expect = 2e-30
Identities = 167/676 (24%), Positives = 264/676 (39%), Gaps = 109/676 (16%)
Query: 2997 VEIFVLDVNDNSPQCSQLLYTGKVHE------DVFPGHFILKVSATDLDTDTNAQITYSL 3050
V I V D NDNSP Y V+E +F G F ATD+D N QI Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG-FSGDNGATDIDDGPNGQIEYVI 191
Query: 3051 H----GPGAHEFKLDPH--TGELTTLTALDRERKDVFNLVAKATDGGG-----RSCQADI 3099
P +++ P TG + L+ E K + ++ +A D R+ +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 3100 TLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDP---------------DQGA 3144
T+ V D +D P F P D + A+ R P DQ
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 3145 NAQ-------VVYSL----PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRAS-DL 3192
N Q ++YS+ P+ F + T + L +P+ +L ++A D
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 3193 GTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG 3252
G P+P + + ++ + P F + + E AP G + LT P
Sbjct: 372 GHPLP--AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 3253 YRVVSGNEQGRFRLD----------ARTGI---LYVNASLDFETSPKYFLSIECSRKSSS 3299
+ + + L +TGI L + +D E Y SI
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF--DGV 487
Query: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
S+ V + + D N++ P FP+ Y V + GD ++ ++A D D N +ITY
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 3360 LIGGNQ--------LGHFTIHP-------------------------KKGELQVAKALDR 3386
++ G Q G TI P G L + KALDR
Sbjct: 548 ILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
Query: 3387 EQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---FQLNYSTTVQE-NSPIG 3442
E Y L + A+D G+P + I V DVNDN P F N S +E N+ +G
Sbjct: 608 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 666
Query: 3443 SKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQ 3502
Q+ +DPD+ NG + + GN + FR+T +G + TA L+R +++Y+L +
Sbjct: 667 ----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 719
Query: 3503 ASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD 3562
A+D + P S ++ + V + +P + V E+ G + +I A D D
Sbjct: 720 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 779
Query: 3563 TLTYSLAEEETLGRHF 3578
++Y + E +HF
Sbjct: 780 NVSYRIRSPEV--KHF 793
Score = 127 bits (319), Expect = 2e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Query: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
Query: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 803 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
Query: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 921
Query: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 922 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 978
Query: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 979 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
Query: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 1039 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1098
Query: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 1099 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1155
Score = 103 bits (258), Expect = 3e-21
Identities = 174/781 (22%), Positives = 297/781 (38%), Gaps = 102/781 (13%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
++RE + +YT I A + E E + V + ++D ND P F SY V + DM
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 167 ICKVTATDADLGQNAEFYYAFNTRSE-MFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
+ ++TA DAD G N E Y ++ F I+ T+G++T+A + + + L V A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 226 RMRKISEGNGFGSLA-----------ALVVHVEPALRKPPAIASVVVTPPDSNDGTTYAT 274
G +L L++ + A+V + D ND
Sbjct: 588 NAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 647
Query: 275 VLVDANSSGAEVESVEVVG----GDPGKHFKAIKSYARSN---------EFSLVSVKDIN 321
+ N S E E+ VG DP Y+ N S+ + +N
Sbjct: 648 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLN 707
Query: 322 WMEYLHGFNLSLQARSGS-GPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSR 380
E + L + A G+ P + + +S F + Y V + E P G+
Sbjct: 708 -REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
Query: 381 VVMVRV--TPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR---- 434
++ + N+ Y ++ F L+ TG ++ + +D+ + I
Sbjct: 767 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
Query: 435 ------TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD-- 486
T P +TV VI + D N++ P+F++ Y G + + GT + V A D D
Sbjct: 827 AFDIYGTMPPGIATVTVI-VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 885
Query: 487 ---HGENGYVTYSIAGP-KALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF 542
Y + P A F ++ G + T ++ E I+ V A D G P
Sbjct: 886 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE-PTTIFKLVVVAFDDGEPV 944
Query: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIV 602
++ + + + + +E + + G + +SA ++ Q++ Y IV
Sbjct: 945 -MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN--QSIVYSIV 1001
Query: 603 SGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDP 662
SGNE + F +N+ +GVI + P L TSY L++ A +L + +
Sbjct: 1002 SGNEEDTFGINNITGVIYVNGP---LDYETRTSYVLRVQAD---------SLEVVLA--- 1046
Query: 663 HFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSI 722
+ VP + V +I +Q++ N++ P F+ F
Sbjct: 1047 NLRVPSKSNTAKV----------YIEIQDE---------------NNHPPVFQKKFYIG- 1080
Query: 723 DVLESVPINTPLARLAATDPDAGFNGKLVY-----VIADGNEEGCFDIELETGLLTVAAP 777
V E + T + R+ ATD D G + Y I +G E F +E TGL+ A
Sbjct: 1081 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAML 1138
Query: 778 LDYEATNFYILNVTV---YDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTE 834
+++ V Y G K+ + VN D PP + I + TE
Sbjct: 1139 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTE 1198
Query: 835 V 835
+
Sbjct: 1199 I 1199
Score = 32.7 bits (73), Expect = 8.1
Identities = 33/136 (24%), Positives = 54/136 (39%), Gaps = 13/136 (9%)
Query: 3411 DIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSD------PDSPENGPPYSF 3464
++ I V D NDN P F +Y TV E +P+G+ + D D P Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 3465 RIT----KGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSG---IPPLSSLTSV 3517
+ N+ + G +V + L+ + Y + IQA+D ++ T++
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 3518 RVHVTEQSHYAPSALP 3533
V V + P LP
Sbjct: 252 TVDVLDGDDLGPMFLP 267
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 249 bits (635), Expect = 5e-65
Identities = 189/661 (28%), Positives = 320/661 (48%), Gaps = 39/661 (5%)
Query: 806 LTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK 865
+ + VKD NDNAP FP ++I E+T + + + D D+ NG Y LL+
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 866 FSLHPLT-------GELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDV 918
F L + +L+V +LDRE + Y++K++ D + Q S L +T+ DV
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVTVSDV 245
Query: 919 NDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV----LMDGAHGTFRV 974
NDN P + +PE+ P GT + L A+D D+G E+RY+ + F +
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 975 DLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPH--- 1031
+ TG + ++R LD E A + +++ ASDG AR T V + V DVN+N PP+
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT---VTINVTDVNDN--PPNIDL 360
Query: 1032 ---FASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM 1088
+ + E P T++ ++ D D+ ++G++ F+ ++ + +
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
Query: 1089 IQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQE 1148
++T + LD E + ++A D G L+ V +++ D NDNPP +Q V S+ E
Sbjct: 421 LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
Query: 1149 DAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH 1208
+ G + + A D DS + + + G FF + TG+L+ ++ DRE ++
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERF 538
Query: 1209 ILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVA 1268
I VT DNG P L+S + V+V +LD NDN P F+H F + E L S V +
Sbjct: 539 IFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV--ITV 596
Query: 1269 SDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPL 1326
+D D G N VT SI +D + F +D +GV+ S+ +F + + T +KATD GQPP
Sbjct: 597 TDADAGENKAVTLSIL-NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 1327 SASVRLHIEWIPWPRPSSIPLA-FDETYYSFTVMETDPVNHMVGVISVEGRPG----LFW 1381
S++ ++ I + S + ++ T + + P + + V +V+ G L +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 1382 FNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD--GSRTIATQVHIFMIA 1439
+SG +K + F I+ TG+I + + L V ++D +++ T V +F+
Sbjct: 716 TIVSGNNKGL-FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Query: 1440 N 1440
N
Sbjct: 775 N 775
Score = 243 bits (621), Expect = 2e-63
Identities = 190/628 (30%), Positives = 297/628 (47%), Gaps = 38/628 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI-ELETG----LLTVA 775
+I + E+ IN+ +ATDPD GFNG Y + +G DI E G L V
Sbjct: 148 NISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQ 207
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ + V D GTPQKSS +L V V D NDN P F G ++ I E+ V
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
Query: 836 GTTIAELTTKDADSEDNGRVRYTL---LSPTEK--FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD N +RY ++P K F+L+ TG + V LDRE +
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
Query: 891 LKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPGTVL 944
+ V A D G + + I + DVNDN P + + + E P T +
Sbjct: 328 VTVLASD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 945 TFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERE--LDFERRAGYNLSLWAS 1002
+ SD D G+V + + + +LE LD+E ++ + AS
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKA-VYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
Query: 1003 DGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSG 1062
D G+P +T V V + D N+N PP F V + V EN+ G + ++A D+DSG
Sbjct: 443 DSGKPSLNQTAL-VRVKLEDENDN--PPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 1063 LDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTE 1122
+ ++ Y L G + F +++ TG++ DRE + TV A D G+ PL S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAA 557
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYM 1182
V + V D NDN P+ + F + E+ P ++V + D D+ +T +I + N
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN-- 615
Query: 1183 GFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIF 1242
F++ P +G++ + DRE + + +V D G+P ST++V + ++DVNDN P+
Sbjct: 616 DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 1243 SHKLFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEA-FSIDLVTG 1298
N +L P+S P V + A D+D G+N + Y+I + + F ID VTG
Sbjct: 676 ISPPSNTSF--KLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTG 733
Query: 1299 VVSSSSTFTAGEYNI--LTIKATDSGQP 1324
++ + + L + +D G P
Sbjct: 734 NITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 228 bits (580), Expect = 1e-58
Identities = 194/649 (29%), Positives = 296/649 (45%), Gaps = 55/649 (8%)
Query: 2668 PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI---- 2723
P + L+ +++ V + P F P+ S PE+ S I A DP
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSAT---DPDTGFNG 175
Query: 2724 ---YSLVRGTTPESNKDGVFSLD-------PDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
Y L+ G + VF LD + V++ +D E Y + +
Sbjct: 176 VQHYELLNGQS-------VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG 228
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVS 2833
S + + V DVNDNRPVF+ + + EN PVGTSVIQ+ A D D G + ++
Sbjct: 229 TPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIR 288
Query: 2834 YRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQ 2893
Y A LFA+++ +G IT + LD E + V+A D T ++A V
Sbjct: 289 YIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVT 345
Query: 2894 VSITDENDNAP----RFASEEYRGSV-VENSEPGELVATLKTLDADISEQNRQVTCYITE 2948
+++TD NDN P R+ G+V + +P L T+ ++ N +V C+I
Sbjct: 346 INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIER 405
Query: 2949 GDPLGQFGISQVGD-EWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDV 3004
P F + V D ++ + + LD E T ++ ++ ASD + V + + D
Sbjct: 406 EVP---FHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 3005 NDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHT 3064
NDN P +Q + V E+ G ++ +SATD D+ NA I Y L GP A F LD T
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKT 521
Query: 3065 GELTTLTALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAV 3122
G LT DRE ++ F A D G QA + + V D NDN+P+F +H V
Sbjct: 522 GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFV 581
Query: 3123 FDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAP 3182
+N + V V+ D D G N V S+ + + +F +D +GVI+ Q+
Sbjct: 582 SENLPKYSTVGVITVTDADAGENKAVTLSILNDND-NFVLDPYSGVIKSNVSFDREQQSS 640
Query: 3183 LELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQ---VPEDAPPGT---E 3236
V+A+D G P P S+ VT++V+ + D PV ++ + VP A PG+ E
Sbjct: 641 YTFDVKATDGGQP-PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAE 699
Query: 3237 VLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSP 3285
V + T AE Y +VSGN +G FR+D TG N +L+ + +P
Sbjct: 700 VFAVDVDTGMNAE-LKYTIVSGNNKGLFRIDPVTG----NITLEEKPAP 743
Score = 222 bits (565), Expect = 7e-57
Identities = 213/787 (27%), Positives = 342/787 (43%), Gaps = 60/787 (7%)
Query: 2160 LVTVRNKSNPLFQSPYYKVR--VPENITLYT-----PILHTQARSPEGLRLIYNIVE--- 2209
L+ + + Q Y +R +PEN+ + I H A + L+Y +V
Sbjct: 12 LIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAG 71
Query: 2210 EEPLM--------LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVL 2261
+ PL+ +FTT + + Y + + F + F ++++
Sbjct: 72 DAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKII 131
Query: 2262 VEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKF 2321
V+D NDN P F V SI E + A+D D+G N Y+++ +G V
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL-NGQSVFGL 190
Query: 2322 FQINGSTGE----MSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPP 2377
+ GE + Q LD E + + +K++ D G P + ++ V VSD+NDN P
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRP 250
Query: 2378 EFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLI---LSGNQDRHFFINSSSG 2434
F++ Q E ++ E A G V+++ A D D + + Y+ ++ R F +N+++G
Sbjct: 251 VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG 310
Query: 2435 IISMFNLCKKHLDSSYNLRVGASDGVFR-ATVPVYINTTNANKYSPEFQQHLYEAE---- 2489
+I++ + + + + V ASDG A V IN T+ N P +
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 2490 --LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIA-TLQKLDRE 2546
L+E V TK+ + DKD+ G + I ++ ++ N + T LD E
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYE 430
Query: 2547 NSTERVIAIKVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPV 2604
+ E + K++A D G T V++ L DENDNPP F +S+ N + +
Sbjct: 431 GTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 2605 IQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQ 2664
+ A D D G+NAD+ Y + P +++ TGV+ E + F + A+
Sbjct: 489 TTISATDEDSGKNADIVYQLGPN---ASFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
Query: 2665 DGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV---KAVAAQDP 2721
D G P S V + V+ + + PKF+ + F E+LP+ S +G++ A A ++
Sbjct: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
Query: 2722 VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLV 2781
+ T N + F LDP +GVIK D E Y DV A S
Sbjct: 606 AV------TLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTA 659
Query: 2782 SVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
V I V DVNDN PV + P +K V +P G+ V +V A+D DTG + ++ Y +
Sbjct: 660 KVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVV-AYDHGQTIQLSSQALVQVSI 2896
+ N LF ID +G I TL+E T H VV D G L + LV + +
Sbjct: 719 S---GNNKGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Query: 2897 TDENDNA 2903
D NA
Sbjct: 775 NDTAGNA 781
Score = 215 bits (548), Expect = 7e-55
Identities = 208/724 (28%), Positives = 325/724 (44%), Gaps = 77/724 (10%)
Query: 872 TGELVVTGH-LDRES---------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDN 921
TGE+ T + +DRE E ++E P+ F + + I ++D NDN
Sbjct: 82 TGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN---DFFRLIKIKIIVKDTNDN 138
Query: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMT--- 978
+P + + +PE+ + A+DPD G G Y L++G F +D++
Sbjct: 139 APMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPE 197
Query: 979 ----GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS 1034
LI+++ LD E++ Y + + DGG P T ++V V DVN+N P F
Sbjct: 198 GEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAI-LQVTVSDVNDN--RPVFKE 254
Query: 1035 FVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAA---FSINQDTGMIQT 1091
+ + EN+P GT VI + A D D G + E++Y A A F++N TG+I
Sbjct: 255 GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSI----- 1146
LDRE + + +TVLA D S P + V I VTD NDNPP + I
Sbjct: 315 QRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVY 372
Query: 1147 -QEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENK 1205
E PV T + + D D+ GK+ I ++ LL T+ LD E
Sbjct: 373 LSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGT 432
Query: 1206 DEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPER------LSPVS 1259
E ++ D+G+PSL T+ V V + D NDNPPIF+ + + + E L+ +S
Sbjct: 433 KEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTIS 492
Query: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIK 1317
A+D D G N + Y + + F +D TGV+++S F E I T+
Sbjct: 493 --------ATDEDSGKNADIVYQL-GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVT 543
Query: 1318 ATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
A D+G PPL + + + + S F ++ F V E P VGVI+V
Sbjct: 544 ARDNGTPPLQSQAAVIVTVLDENDNSP---KFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1374 EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---RTIA 1430
G +I D D +F ++ +G I D ++S+Y V+ TDG R+
Sbjct: 601 AGENKAVTLSIL-NDND-NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1431 TQVHIFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYT 1484
+V I + ++N + P + T +++ VP +PG + V A+D D G + L YT
Sbjct: 659 AKVTI-NVMDVNDNSPVVISPPSNTSFKL-VPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 1485 IHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK-RNFVWVTI 1543
I + G LF++DP +G +T+ + + H L V + D P V V +
Sbjct: 717 IVSGNNKG---LFRIDPVTG-NITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFL 772
Query: 1544 HVED 1547
+V D
Sbjct: 773 YVND 776
Score = 212 bits (539), Expect = 7e-54
Identities = 190/752 (25%), Positives = 321/752 (42%), Gaps = 43/752 (5%)
Query: 2806 LTENMPVGT--SVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWI-TTLQE 2862
L EN+P+G + ++ I+ TG + YRL + G L + S +G I TT
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDA--PLVKVSSSTGEIFTTSNR 91
Query: 2863 LDCETC---QTYHFHVVAYDHGQTIQLSSQAL----VQVSITDENDNAPRFASEEYRGSV 2915
+D E +Y + + + L + +++ + D NDNAP F S S+
Sbjct: 92 IDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISI 151
Query: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV----GDEW-RISSRK 2970
EN+ D D Q + G + FG+ V G++W ++ ++
Sbjct: 152 PENTLINSRFPIPSATDPDTGFNGVQ-HYELLNGQSV--FGLDIVETPEGEKWPQLIVQQ 208
Query: 2971 TLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
LDRE Y++++ DG + ++ +++ V DVNDN P + + E+ G
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVG 268
Query: 3028 HFILKVSATDLDTDTNAQITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNL 3083
++++ ATD D +NA+I Y A F L+ TG +T +LDRE + +
Sbjct: 269 TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKV 328
Query: 3084 VAKATDGGGRSCQADITLHVEDVNDNAPRF------FPSHCAVAVFDNTTVKTPVAVVFA 3137
A+DG +A +T++V DVNDN P P + V + + V T +A++
Sbjct: 329 TVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388
Query: 3138 RDPDQGANAQVVYSLPDSAEGHF-SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPI 3196
D D N +V+ + H ++ ++ L + ASD G P
Sbjct: 389 SDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP- 447
Query: 3197 PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVV 3256
L+ V V + D P+F + V E+ G + ++ +
Sbjct: 448 SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
Query: 3257 SGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNE 3316
G F LD +TG+L + D E ++ ++ + L V+V + D N+
Sbjct: 508 LGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEND 567
Query: 3317 HRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKG 3376
+ P+F + + V EN + ++ TD D N +T S++ N +F + P G
Sbjct: 568 NSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND--NFVLDPYSG 625
Query: 3377 ELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTT-- 3434
++ + DREQ SSY+ ++ATD GQPP + I V DVNDN P +T+
Sbjct: 626 VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFK 685
Query: 3435 -VQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRR 3492
V ++ GS V ++ D D+ N + I GNN FR+ P G + E +
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAE-LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPT 744
Query: 3493 AQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
++L + SD G P L +L V ++V +
Sbjct: 745 DVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 202 bits (515), Expect = 5e-51
Identities = 176/624 (28%), Positives = 276/624 (44%), Gaps = 36/624 (5%)
Query: 2962 DEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVH 3021
D ++ + + E+ + L V F + ++I V D NDN+P + +
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIP 152
Query: 3022 EDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTGELTTLTALD 3074
E+ SATD DT N Y L G F LD +L LD
Sbjct: 153 ENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQQNLD 211
Query: 3075 RERKDVFNLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPV 3132
RE+KD + + K DGG +S A + + V DVNDN P F V + +N V T V
Sbjct: 212 REQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSV 271
Query: 3133 AVVFARDPDQGANAQVVY----SLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
+ A D D G+NA++ Y + + + F+++ TTG+I +++ L A ++TV
Sbjct: 272 IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVL 331
Query: 3189 ASDLGTPIPLSTLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLAT 3242
ASD G+ P TVT++V + D P + +V + E P T++ L T
Sbjct: 332 ASD-GSSTPARA--TVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA-LIT 387
Query: 3243 LTRPGAEKTGYRVVSGNEQGRFRLDA---RTGILYVNASLDFETSPKYFLSIECSRKSSS 3299
++ + G + + F L A +L ++ LD+E + ++ I S
Sbjct: 388 VSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
SL+ V V + D N++ P F Q V EN G + T+SATDED N+DI Y
Sbjct: 448 SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
Query: 3360 LIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADV 3419
L G F + K G L ++ DRE+ + + A D+G PPL + + V D
Sbjct: 508 L--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 3420 NDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP 3479
NDN P+F ++ V EN P S V + ++D D+ EN + ++ N+ F + P
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN---KAVTLSILNDNDNFVLDP 622
Query: 3480 -DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP---SALPLE 3535
G + + R Q Y ++A+D G PP SS V ++V + + +P S
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 3536 IFITVGEDEFQGGMVGKIHATDRD 3559
F V G +V ++ A D D
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVD 706
Score = 201 bits (510), Expect = 2e-50
Identities = 193/738 (26%), Positives = 328/738 (44%), Gaps = 101/738 (13%)
Query: 429 YQLHIRTSPGQASTVVVIDIV--DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486
++L + P ++ I I+ D N++AP+F + ++ EN + +ATD D
Sbjct: 111 FELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPD 170
Query: 487 HGENGYVTYSIAGPKALPFSIDPYLGIIST-----------SKPMDYELMKRIYTFRVRA 535
G NG Y + +++ F +D I+ T + +D E K Y +++
Sbjct: 171 TGFNGVQHYELLNGQSV-FGLD----IVETPEGEKWPQLIVQQNLDRE-QKDTYVMKIKV 224
Query: 536 SDWGSPFRREKEVSIFLQLR--NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE 593
D G+P +K + LQ+ ++NDN+P+F+E I ++ PVG S++ + A D D
Sbjct: 225 EDGGTP---QKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADI 281
Query: 594 LQNLKYEIVSGNEL-----EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNY 648
N + + G ++ F LN+ +G+I+++R +L + + + + ASDG +
Sbjct: 282 GSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQR---SLDREETAIHKVTVLASDGSST 338
Query: 649 AS--PTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706
+ T+N+T V D P D +++ T+
Sbjct: 339 PARATVTINVTDVNDN----PPNIDLRYIISPINGTVY---------------------- 372
Query: 707 INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766
+ E P+NT +A + +D D NGK++ I E F ++
Sbjct: 373 -----------------LSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLK 412
Query: 767 L---ETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG 823
LL ++ LDYE T + + D G P + L+ V ++D NDN P F
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQP 472
Query: 824 GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDR 883
+L++SE+ G + ++ D DS N + Y L F L TG L + DR
Sbjct: 473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 884 ESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTV 943
E + R+I V ARD + L S +I+T+ D NDNSP+ H + V E+LP +
Sbjct: 533 EEQERFIFTVTARDNGTP--PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYST 590
Query: 944 LTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASD 1003
+ + +D D G V +++ + F +D +G + D E+++ Y + A+D
Sbjct: 591 VGVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1004 GGRPLARRTLCHVEVIVLDVNEN----LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059
GG+P R + V + V+DVN+N + PP SF V ++ G+ V V A D
Sbjct: 650 GGQP-PRSSTAKVTINVMDVNDNSPVVISPPSNTSF---KLVPLSAIPGSVVAEVFAVDV 705
Query: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMI---QTLAPLDREFASYYWLTVLAVDRG-SV 1115
D+G++ EL+Y + +G F I+ TG I + AP D + L V D G
Sbjct: 706 DTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTD---VGLHRLVVNISDLGYPK 762
Query: 1116 PLSSVTEVYIEVTDANDN 1133
L ++ V++ V D N
Sbjct: 763 SLHTLVLVFLYVNDTAGN 780
Score = 199 bits (506), Expect = 5e-50
Identities = 187/688 (27%), Positives = 301/688 (43%), Gaps = 44/688 (6%)
Query: 2025 GVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTE 2084
G ++ E + EL V + N + + +++ ++D NDN P F I + T
Sbjct: 100 GASYAEENECFFELEVVILPNDFFRLIK---IKIIVKDTNDNAPMFPSPVINISIPENTL 156
Query: 2085 PGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRID-------PYLGDISLKKPFDYQALN 2137
SATD D G NG YE + F +D + +++ D + +
Sbjct: 157 INSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKD 216
Query: 2138 KYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQA 2195
Y +K+ DGGTP S + VTV N + P+F+ +V +PEN + T ++ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 2196 RSPE-----GLRLIYNI-VEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTA 2249
+ +R I+ V LF + TG++TV LD E H TV A+D +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGS 336
Query: 2250 LGSFSEATVEVLVEDVNDNPPTF------SQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
+ + ATV + V DVNDNPP S + T +SE P T + + SD+D+
Sbjct: 337 -STPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDV 395
Query: 2304 NRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGET 2363
N V I + K N E S++ LDYE + F K+ A D G P L
Sbjct: 396 NGKVICFIEREVPFHLKAVYDNQYLLETSSL--LDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 2364 LVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQ 2423
LV V + D NDNPP F QP E +VSE G + + A D DS + + Y + G
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPN 511
Query: 2424 DRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPE 2480
F ++ +G+++ + + + V A D ++ V + + N SP+
Sbjct: 512 ASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPK 571
Query: 2481 FQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIAT 2539
F + ++ ++EN + V + D D+G + +I+N ++ F ++P +G I +
Sbjct: 572 FTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND--NDNFVLDPYSGVIKS 629
Query: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQFKASEYTVS---I 2594
DRE + +K A DGG T K+ + D NDN P + S +
Sbjct: 630 NVSFDREQQSSYTFDVK--ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV 687
Query: 2595 QSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLEN 2654
+ S V +V A D D G NA++ Y++ + K + I+PVTG + +++ +
Sbjct: 688 PLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGN-NKGLFRIDPVTGNITLEEKPAPTDV 746
Query: 2655 QTLDFFIKAQD-GGPPHWNSLVPVRLQV 2681
+ D G P ++LV V L V
Sbjct: 747 GLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 196 bits (498), Expect = 4e-49
Identities = 190/689 (27%), Positives = 303/689 (43%), Gaps = 90/689 (13%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L +++IV D N+N P F S V + EN+ ++ + +A D D+G +G Y L
Sbjct: 125 LIKIKIIVKDTNDNA--PMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL 182
Query: 1073 AGTGLAAFSI-----NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
G + I + + LDRE Y + + D G+ SS + + V
Sbjct: 183 NGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNI---TSGNYMGF 1184
+D NDN P + I E+APVGTSV+QL A D D S ++ + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H +VTVL + S + + V + + DVNDNPP
Sbjct: 303 FALNNTTGLITVQRSLDREETAIH--KVTVLASDGSSTPARATVTINVTDVNDNPP---- 356
Query: 1245 KLFNVRLPERLSPVSPGPVYR------------LVASDLDEGLNGRVTYSIEDSDEEAFS 1292
N+ L +SP++ G VY + SD D +NG+V IE E F
Sbjct: 357 ---NIDLRYIISPIN-GTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIER--EVPFH 410
Query: 1293 IDLVTGVVSSSSTFTAGEYN-----ILTIKATDSGQPPLS--ASVRLHIEWIPWPRPSSI 1345
+ V T + +Y I A+DSG+P L+ A VR+ +E +
Sbjct: 411 LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE-----DENDN 465
Query: 1346 PLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD------------- 1392
P F++ +V E + R GL+ IS D+D
Sbjct: 466 PPIFNQPVIELSVSENN-------------RRGLYLTTISATDEDSGKNADIVYQLGPNA 512
Query: 1393 --FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQF 1448
FD+++ TG + +R D + + TV D G+ + +Q + + + + N + P+F
Sbjct: 513 SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF 572
Query: 1449 LETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVT 1508
++ V ++ + + D D G++ T+ D + F LDP SGV+ +
Sbjct: 573 THNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDPYSGVIKS 629
Query: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGN------LHPPRFTQLHYEA 1562
D S +T V D P + + VTI+V D N + PP T
Sbjct: 630 NVSFDREQ-QSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL-- 686
Query: 1563 SVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQAN 1622
VP + PG+ + +V A+D D G+NAE+ Y+++ GN++G F I+ + G ITL +K +
Sbjct: 687 -VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTD 745
Query: 1623 HAPHTLTVKAEDQGSPQ-WHDLATVIIHV 1650
H L V D G P+ H L V ++V
Sbjct: 746 VGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 191 bits (485), Expect = 1e-47
Identities = 192/752 (25%), Positives = 319/752 (42%), Gaps = 85/752 (11%)
Query: 1457 VPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSG-VLVTVGKLD-- 1513
VP +P + L + I+ G S G A L ++ S+G + T ++D
Sbjct: 38 VPIGNIP--KDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 1514 -LGSGPSQHTLTVMVRDQEIPIKRN----FVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
L +G S + E+ I N + + I V+D N + P F S+P+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENT 155
Query: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNI-----NALLGIITLAQKLDQANH 1623
+ A D D G N HY LL G S +I + + Q LD+
Sbjct: 156 LINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQK 215
Query: 1624 APHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVS 1683
+ + +K ED G+PQ A + + V + + P+F + + V IPE+ PVG+ ++ +
Sbjct: 216 DTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLH 275
Query: 1684 AM-----SPSEVTY----ELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSN 1734
A S +E+ Y ++ K +F++N+ +GLI+ Q+ LD E+ + +++ + S+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATK-RLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 1735 MAGAFTDVMVVVDIIDENDNAP----MFLKSTFVGQI--SEAAPLYSMIMDKNNNPFVIH 1788
+ V +++ D NDN P ++ S G + SE P+ N +I
Sbjct: 335 GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPV-------NTKIALIT 387
Query: 1789 ASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP 1848
SD D + N ++ I + + L S +DYE F F + D G P
Sbjct: 388 VSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 1849 VLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK 1908
L + A V + + D ND+PP F++ + E+++ G+ L + A+DEDS
Sbjct: 448 SL--NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS------- 498
Query: 1909 TGNADEAVTIHPVTGSISVLNPAFLGLSRK-------------------LTIRASDG--- 1946
NAD + P N +F L RK T+ A D
Sbjct: 499 GKNADIVYQLGP--------NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTP 550
Query: 1947 LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYF 2004
Q A V +++ D S +F + + V ENL + ++ N ++
Sbjct: 551 PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLS 610
Query: 2005 LLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
+LN D F + +GV+++ V+FDREQQ ++ V+ D P R + V +++ DVN
Sbjct: 611 ILNDNDNFVLDPYSGVIKS-NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVN 669
Query: 2065 DNPPKFKHLPYYT---IIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF--AEDYTYFRID 2119
DN P P T ++ PG V+ +V A D D G N + Y + FRID
Sbjct: 670 DNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRID 729
Query: 2120 PYLGDISLKKPFDYQALNKYHLKVIARDGGTP 2151
P G+I+L++ + + L V D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 180 bits (457), Expect = 2e-44
Identities = 168/670 (25%), Positives = 303/670 (45%), Gaps = 51/670 (7%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG-N 1180
++ I V D NDN P V SI E+ + + A DPD+ G + + +G +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 1181 YMGFFMIHPVTG----LLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236
G ++ G L Q LDRE KD +++++ V D G P ST+ + V + DVN
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
Query: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTY----SIEDSDEEAFS 1292
DN P+F V +PE +PV V +L A+D D G N + Y + + + F+
Sbjct: 247 DNRPVFKEGQVEVHIPEN-APVGTS-VIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 1293 IDLVTGVVSSSSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFD 1350
++ TG+++ + E I +T+ A+D P A+V +++ + P +I L +
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVN-DNPPNIDLRYI 363
Query: 1351 ETYYSFTVM--ETDPVNHMVGVISVEGRPGLFWFNISGG-----DKDMDFDIEKTTGSIV 1403
+ + TV E DPVN + +I+V + +++G ++++ F ++ +
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDT----DVNGKVICFIEREVPFHLKAVYDNQY 419
Query: 1404 IARP---LDTRRRSNYNLTVEVTDGSRTIATQVHIFMIA--NINHHRPQFLETRYEVRVP 1458
+ LD ++ + +D + Q + + + N + P F + E+ V
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVS 479
Query: 1459 QDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGS 1516
++ G+ L + A D+D GK+ ++Y + + AS F LD +GVL T ++
Sbjct: 480 ENNRRGLYLTTISATDEDSGKNADIVYQLGPN-----ASFFDLDRKTGVL-TASRVFDRE 533
Query: 1517 GPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQ 1576
+ TV RD P ++ V + V D N + P+FT H++ V + + + +
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 1577 VRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQG 1636
+ DAD G N V S+L N F ++ G+I D+ + +T VKA D G
Sbjct: 594 ITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1637 SPQWHDLATVIIHVYPSDRSAPIF---SKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
P A V I+V + ++P+ + F +P S GS + V A+ +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA---GAFTDVMVV 1745
E+ Y + GN G+F ++ +G I+ ++K + ++L + S++ T V+V
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771
Query: 1746 VDIIDENDNA 1755
+ + D NA
Sbjct: 772 LYVNDTAGNA 781
Score = 174 bits (442), Expect = 1e-42
Identities = 199/768 (25%), Positives = 333/768 (43%), Gaps = 98/768 (12%)
Query: 1668 EIPESIPVGS-----PILLVSAMSPSEVTYELREGNKDG---VFSMNSYSG-LISTQKKL 1718
E+PE++P+G+ I ++A + + + R +K G + ++S +G + +T ++
Sbjct: 33 ELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 1719 DHEKI---SSY----------QLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
D EK+ +SY ++ I ++ F + + + + D NDNAPMF
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDF---FRLIKIKIIVKDTNDNAPMF------- 142
Query: 1766 QISEAAPLYSMIMDKN---NNPFVI-HASDSDKEANSLLVYKILEPEALKFFKID----- 1816
+P+ ++ + +N N+ F I A+D D N + Y++L +++ F +D
Sbjct: 143 ----PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV--FGLDIVETP 196
Query: 1817 --PSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874
L + +D E ++ + V D G+P + QV V DVND+ P F E
Sbjct: 197 EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT--VSDVNDNRPVFKE 254
Query: 1875 QIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK-------TGNADEAVTIHPVTGSISV 1927
EV I G ++ + A+D D N I+ ++ TG I+V
Sbjct: 255 GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 1928 LNPAFLGLSR------KLTIRASDGLYQDT-ALVKISLTQVLDKSLQFD--------QDV 1972
L R K+T+ ASDG A V I++T V D D
Sbjct: 315 QR----SLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 1973 YWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHM---VQSAGVLQTRGVAFD 2029
+ + K+ + + AL+ + + +N + F+ FH+ + +L+T + D
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETSSL-LD 428
Query: 2030 REQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVL 2089
E + D+ P LVRV +ED NDNPP F + + G L
Sbjct: 429 YEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 2090 FQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
+SATDED G N + Y+ + ++F +D G ++ + FD + ++ V ARD G
Sbjct: 489 TTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNG 548
Query: 2150 TPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLYTP---ILHTQARSPEGLRLI 2204
TP LQS+ V+VTV N ++P F +++ V EN+ Y+ I T A + E +
Sbjct: 549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVT 608
Query: 2205 YNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVE 2263
+I+ + F D +GV+ D E ++ + F V+ATD S A V + V
Sbjct: 609 LSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVM 666
Query: 2264 DVNDNPPTFSQLVYTTSIS----EGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS 2319
DVNDN P TS +P V ++ A D D+G N ++ Y IV +
Sbjct: 667 DVNDNSPVVISPPSNTSFKLVPLSAIPGSV-VAEVFAVDVDTGMNAELKYTIVSGNN--K 723
Query: 2320 KFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVV 2367
F+I+ TG + T++E H V + P + TLV+V
Sbjct: 724 GLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
Score = 161 bits (408), Expect = 1e-38
Identities = 143/546 (26%), Positives = 253/546 (46%), Gaps = 47/546 (8%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + I+ + ++ T ++ V + D ND +P+F V I E+ P+ +
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 166 PICKVTATDADLGQNAEFYYAFNTR-----SEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G NAE Y F + +FA++ T+G++TV L+ H++
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDAN 280
VLA S+G+ + A + ++V PP I + P + GT Y L + +
Sbjct: 330 VLA-------SDGSSTPARATVTINVTDVNDNPPNIDLRYIISPIN--GTVY---LSEKD 377
Query: 281 SSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM---------EYLHGFNL 331
++ + V D + K I R F L +V D ++ E F+
Sbjct: 378 PVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437
Query: 332 SLQARSGSGPYF-YSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAF 390
+ A P + + L + F + V + +SE + G + + T
Sbjct: 438 KIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDED 497
Query: 391 P----NLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQAS 441
++ Y L P++ F L+ +TG++T +++ D ++ + + T P Q+
Sbjct: 498 SGKNADIVYQLGPNASF--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQ 555
Query: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
V++ ++D N+++P F + + + EN+P ++V +T TD D GEN VT SI
Sbjct: 556 AAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN 615
Query: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
F +DPY G+I ++ D E + YTF V+A+D G P R + + + ++NDN
Sbjct: 616 D-NFVLDPYSGVIKSNVSFDRE-QQSSYTFDVKATDGGQP-PRSSTAKVTINVMDVNDNS 672
Query: 562 PMFEEVNCTGSIR---QDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFS 616
P+ S + G + + A+DVD N LKY IVSGN F ++ +
Sbjct: 673 PVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
Query: 617 GVISLK 622
G I+L+
Sbjct: 733 GNITLE 738
Score = 159 bits (403), Expect = 4e-38
Identities = 168/640 (26%), Positives = 280/640 (43%), Gaps = 58/640 (9%)
Query: 3031 LKVSATDLDTDTNAQITYSLHGPG--AHEFKLDPHTGEL-TTLTALDRERKDVFNLVAKA 3087
L +S + T T+A + Y L A K+ TGE+ TT +DRE+ L A A
Sbjct: 47 LNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREK-----LCAGA 101
Query: 3088 TDGGGRSCQAD---------------ITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPV 3132
+ C + I + V+D NDNAP F +++ +NT + +
Sbjct: 102 SYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRF 161
Query: 3133 AVVFARDPDQGANAQVVYSLPD--SAEGHFSIDATTGV----IRLEKPLQVRPQAPLELT 3186
+ A DPD G N Y L + S G ++ G + +++ L + +
Sbjct: 162 PIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMK 221
Query: 3187 VRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP 3246
++ D GTP ST + V+V + D PVF + V +PE+AP GT V+QL
Sbjct: 222 IKVEDGGTPQKSST-AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDAD 280
Query: 3247 GAEKTGYRVVSGNE-----QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSL 3301
R + G + + F L+ TG++ V SLD E + + +++ S SS+
Sbjct: 281 IGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA 340
Query: 3302 SDVTTVMVNITDVNEHRP----QFPQDPYSTRVL--ENALVGDVILTVSATDEDGPLNSD 3355
TV +N+TDVN++ P ++ P + V E V I ++ +D+D +N
Sbjct: 341 R--ATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGK 398
Query: 3356 ITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQ 3415
+ + ++ + L+ + LD E +S K+ A+DSG+P L++ + ++
Sbjct: 399 VICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVK 458
Query: 3416 VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAF 3475
+ D NDNPP F Q +V EN+ G + + +D DS +N G N S F
Sbjct: 459 LEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA---DIVYQLGPNASFF 515
Query: 3476 RVTPDGWLVTAEGL-SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPL 3534
+ ++TA + R QE + + A D+G PPL S +V V V +++ +P
Sbjct: 516 DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHN 575
Query: 3535 EIFITVGEDEFQGGMVGKIHATDRDPQD--TLTYSLAEEETLGRHFSVGAPDGKIIAAQG 3592
V E+ + VG I TD D + +T S+ + +F + G I +
Sbjct: 576 HFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND---NFVLDPYSGVIKSNVS 632
Query: 3593 LPR---GHYSFNVTVSDG---TFTTTAGVHVYVWHVGQEA 3626
R Y+F+V +DG ++TA V + V V +
Sbjct: 633 FDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Score = 120 bits (300), Expect = 4e-26
Identities = 165/715 (23%), Positives = 291/715 (40%), Gaps = 86/715 (12%)
Query: 131 LTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTR 190
L ++ + + D ND P+F P ++I E+ + S +ATD D G N +Y
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
Query: 191 SEMFAIHPTSGVVTVAGK----LNVTWRGKHELQVLAVDRMRKISEGNG--FGSLAALVV 244
+F + V T G+ L V E + V ++ K+ +G S A L V
Sbjct: 185 QSVFGLDI---VETPEGEKWPQLIVQQNLDREQKDTYVMKI-KVEDGGTPQKSSTAILQV 240
Query: 245 HVEPALRKPPAIASVVVT---PPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFK 301
V P V P ++ GT+ + G+ E + G K
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 302 AIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIR-----GFHLPPSK 356
+ +A +N L++V+ E +++ A GS + + PP+
Sbjct: 301 RL--FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNI 358
Query: 357 LSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPSSENVGFKLNA---RT 412
V LSE P +++ ++ V+ ++ V+ V F L A
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 413 GLITTTKLMDFHDRAHYQLHIRTS----PGQASTVVV-IDIVDCNNHAPLFNRSSYDGTL 467
L+ T+ L+D+ + I S P T +V + + D N++ P+FN+ + ++
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSV 478
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
EN G + ++ATD D G+N + Y + GP A F +D G+++ S+ D E +R
Sbjct: 479 SENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKTGVLTASRVFDREEQER 537
Query: 528 IYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMS 587
+ F V A D G+P + + ++ + + + NDN P F + + ++ P ++ ++
Sbjct: 538 -FIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 588 AIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKN 647
D D +N + N+ + F L+ +SGVI ++ Q +SY+ + A+DG
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSN---VSFDREQQSSYTFDVKATDGGQ 652
Query: 648 YASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706
+T +T+ V D + PV V++ + T +
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPV------VISPPSNTSFKLV------------------- 687
Query: 707 INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766
L ++P + +A + A D D G N +L Y I GN +G F I+
Sbjct: 688 -----------------PLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRID 729
Query: 767 LETGLLTV---AAPLDYEATNFYILNVTVYDLGTPQK-SSWKLLTVNVKDWNDNA 817
TG +T+ AP D + L V + DLG P+ + L+ + V D NA
Sbjct: 730 PVTGNITLEEKPAPTD---VGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA 781
Score = 63.5 bits (153), Expect = 4e-09
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 18/261 (6%)
Query: 106 LLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLK 164
+ +RE ++ + + A + T L++ V+V +LD+ND P F+ ++ +SE++P
Sbjct: 529 VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588
Query: 165 SPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAV 224
S + +T TDAD G+N + ++ F + P SGV+ + + + V A
Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 225 DRMRKISEGNGFGSLAALVVH-VEPALRKPPAIASVVVTPPDSNDGTTYATVL-VDANSS 282
D + ++ + V+ P + PP+ S + P + G+ A V VD ++
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
Query: 283 -GAEVESVEVVGG-------DPGKHFKAIKSYARSNEFSL----VSVKDINWMEYLHGF- 329
AE++ V G DP ++ + L V++ D+ + + LH
Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Query: 330 --NLSLQARSGSGPYFYSQIR 348
L + +G+ Y Y IR
Sbjct: 769 LVFLYVNDTAGNASYIYDLIR 789
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 249 bits (635), Expect = 5e-65
Identities = 189/661 (28%), Positives = 320/661 (48%), Gaps = 39/661 (5%)
Query: 806 LTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK 865
+ + VKD NDNAP FP ++I E+T + + + D D+ NG Y LL+
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 866 FSLHPLT-------GELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDV 918
F L + +L+V +LDRE + Y++K++ D + Q S L +T+ DV
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVTVSDV 245
Query: 919 NDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV----LMDGAHGTFRV 974
NDN P + +PE+ P GT + L A+D D+G E+RY+ + F +
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 975 DLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPH--- 1031
+ TG + ++R LD E A + +++ ASDG AR T V + V DVN+N PP+
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT---VTINVTDVNDN--PPNIDL 360
Query: 1032 ---FASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM 1088
+ + E P T++ ++ D D+ ++G++ F+ ++ + +
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
Query: 1089 IQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQE 1148
++T + LD E + ++A D G L+ V +++ D NDNPP +Q V S+ E
Sbjct: 421 LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
Query: 1149 DAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH 1208
+ G + + A D DS + + + G FF + TG+L+ ++ DRE ++
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERF 538
Query: 1209 ILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVA 1268
I VT DNG P L+S + V+V +LD NDN P F+H F + E L S V +
Sbjct: 539 IFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV--ITV 596
Query: 1269 SDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPL 1326
+D D G N VT SI +D + F +D +GV+ S+ +F + + T +KATD GQPP
Sbjct: 597 TDADAGENKAVTLSIL-NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 1327 SASVRLHIEWIPWPRPSSIPLA-FDETYYSFTVMETDPVNHMVGVISVEGRPG----LFW 1381
S++ ++ I + S + ++ T + + P + + V +V+ G L +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 1382 FNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD--GSRTIATQVHIFMIA 1439
+SG +K + F I+ TG+I + + L V ++D +++ T V +F+
Sbjct: 716 TIVSGNNKGL-FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Query: 1440 N 1440
N
Sbjct: 775 N 775
Score = 243 bits (621), Expect = 2e-63
Identities = 190/628 (30%), Positives = 297/628 (47%), Gaps = 38/628 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI-ELETG----LLTVA 775
+I + E+ IN+ +ATDPD GFNG Y + +G DI E G L V
Sbjct: 148 NISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQ 207
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ + V D GTPQKSS +L V V D NDN P F G ++ I E+ V
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
Query: 836 GTTIAELTTKDADSEDNGRVRYTL---LSPTEK--FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD N +RY ++P K F+L+ TG + V LDRE +
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
Query: 891 LKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPGTVL 944
+ V A D G + + I + DVNDN P + + + E P T +
Sbjct: 328 VTVLASD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 945 TFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERE--LDFERRAGYNLSLWAS 1002
+ SD D G+V + + + +LE LD+E ++ + AS
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKA-VYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
Query: 1003 DGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSG 1062
D G+P +T V V + D N+N PP F V + V EN+ G + ++A D+DSG
Sbjct: 443 DSGKPSLNQTAL-VRVKLEDENDN--PPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 1063 LDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTE 1122
+ ++ Y L G + F +++ TG++ DRE + TV A D G+ PL S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAA 557
Query: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYM 1182
V + V D NDN P+ + F + E+ P ++V + D D+ +T +I + N
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN-- 615
Query: 1183 GFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIF 1242
F++ P +G++ + DRE + + +V D G+P ST++V + ++DVNDN P+
Sbjct: 616 DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 1243 SHKLFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEA-FSIDLVTG 1298
N +L P+S P V + A D+D G+N + Y+I + + F ID VTG
Sbjct: 676 ISPPSNTSF--KLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTG 733
Query: 1299 VVSSSSTFTAGEYNI--LTIKATDSGQP 1324
++ + + L + +D G P
Sbjct: 734 NITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 228 bits (580), Expect = 1e-58
Identities = 194/649 (29%), Positives = 296/649 (45%), Gaps = 55/649 (8%)
Query: 2668 PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI---- 2723
P + L+ +++ V + P F P+ S PE+ S I A DP
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSAT---DPDTGFNG 175
Query: 2724 ---YSLVRGTTPESNKDGVFSLD-------PDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
Y L+ G + VF LD + V++ +D E Y + +
Sbjct: 176 VQHYELLNGQS-------VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG 228
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVS 2833
S + + V DVNDNRPVF+ + + EN PVGTSVIQ+ A D D G + ++
Sbjct: 229 TPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIR 288
Query: 2834 YRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQ 2893
Y A LFA+++ +G IT + LD E + V+A D T ++A V
Sbjct: 289 YIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVT 345
Query: 2894 VSITDENDNAP----RFASEEYRGSV-VENSEPGELVATLKTLDADISEQNRQVTCYITE 2948
+++TD NDN P R+ G+V + +P L T+ ++ N +V C+I
Sbjct: 346 INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIER 405
Query: 2949 GDPLGQFGISQVGD-EWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDV 3004
P F + V D ++ + + LD E T ++ ++ ASD + V + + D
Sbjct: 406 EVP---FHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 3005 NDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHT 3064
NDN P +Q + V E+ G ++ +SATD D+ NA I Y L GP A F LD T
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKT 521
Query: 3065 GELTTLTALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAV 3122
G LT DRE ++ F A D G QA + + V D NDN+P+F +H V
Sbjct: 522 GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFV 581
Query: 3123 FDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAP 3182
+N + V V+ D D G N V S+ + + +F +D +GVI+ Q+
Sbjct: 582 SENLPKYSTVGVITVTDADAGENKAVTLSILNDND-NFVLDPYSGVIKSNVSFDREQQSS 640
Query: 3183 LELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQ---VPEDAPPGT---E 3236
V+A+D G P P S+ VT++V+ + D PV ++ + VP A PG+ E
Sbjct: 641 YTFDVKATDGGQP-PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAE 699
Query: 3237 VLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSP 3285
V + T AE Y +VSGN +G FR+D TG N +L+ + +P
Sbjct: 700 VFAVDVDTGMNAE-LKYTIVSGNNKGLFRIDPVTG----NITLEEKPAP 743
Score = 222 bits (565), Expect = 7e-57
Identities = 213/787 (27%), Positives = 342/787 (43%), Gaps = 60/787 (7%)
Query: 2160 LVTVRNKSNPLFQSPYYKVR--VPENITLYT-----PILHTQARSPEGLRLIYNIVE--- 2209
L+ + + Q Y +R +PEN+ + I H A + L+Y +V
Sbjct: 12 LIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAG 71
Query: 2210 EEPLM--------LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVL 2261
+ PL+ +FTT + + Y + + F + F ++++
Sbjct: 72 DAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKII 131
Query: 2262 VEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKF 2321
V+D NDN P F V SI E + A+D D+G N Y+++ +G V
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL-NGQSVFGL 190
Query: 2322 FQINGSTGE----MSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPP 2377
+ GE + Q LD E + + +K++ D G P + ++ V VSD+NDN P
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRP 250
Query: 2378 EFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLI---LSGNQDRHFFINSSSG 2434
F++ Q E ++ E A G V+++ A D D + + Y+ ++ R F +N+++G
Sbjct: 251 VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG 310
Query: 2435 IISMFNLCKKHLDSSYNLRVGASDGVFR-ATVPVYINTTNANKYSPEFQQHLYEAE---- 2489
+I++ + + + + V ASDG A V IN T+ N P +
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 2490 --LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIA-TLQKLDRE 2546
L+E V TK+ + DKD+ G + I ++ ++ N + T LD E
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYE 430
Query: 2547 NSTERVIAIKVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPV 2604
+ E + K++A D G T V++ L DENDNPP F +S+ N + +
Sbjct: 431 GTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 2605 IQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQ 2664
+ A D D G+NAD+ Y + P +++ TGV+ E + F + A+
Sbjct: 489 TTISATDEDSGKNADIVYQLGPN---ASFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
Query: 2665 DGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV---KAVAAQDP 2721
D G P S V + V+ + + PKF+ + F E+LP+ S +G++ A A ++
Sbjct: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
Query: 2722 VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLV 2781
+ T N + F LDP +GVIK D E Y DV A S
Sbjct: 606 AV------TLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTA 659
Query: 2782 SVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
V I V DVNDN PV + P +K V +P G+ V +V A+D DTG + ++ Y +
Sbjct: 660 KVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVV-AYDHGQTIQLSSQALVQVSI 2896
+ N LF ID +G I TL+E T H VV D G L + LV + +
Sbjct: 719 S---GNNKGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Query: 2897 TDENDNA 2903
D NA
Sbjct: 775 NDTAGNA 781
Score = 215 bits (548), Expect = 7e-55
Identities = 208/724 (28%), Positives = 325/724 (44%), Gaps = 77/724 (10%)
Query: 872 TGELVVTGH-LDRES---------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDN 921
TGE+ T + +DRE E ++E P+ F + + I ++D NDN
Sbjct: 82 TGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN---DFFRLIKIKIIVKDTNDN 138
Query: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMT--- 978
+P + + +PE+ + A+DPD G G Y L++G F +D++
Sbjct: 139 APMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPE 197
Query: 979 ----GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS 1034
LI+++ LD E++ Y + + DGG P T ++V V DVN+N P F
Sbjct: 198 GEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAI-LQVTVSDVNDN--RPVFKE 254
Query: 1035 FVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAA---FSINQDTGMIQT 1091
+ + EN+P GT VI + A D D G + E++Y A A F++N TG+I
Sbjct: 255 GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 1092 LAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSI----- 1146
LDRE + + +TVLA D S P + V I VTD NDNPP + I
Sbjct: 315 QRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVY 372
Query: 1147 -QEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENK 1205
E PV T + + D D+ GK+ I ++ LL T+ LD E
Sbjct: 373 LSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGT 432
Query: 1206 DEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPER------LSPVS 1259
E ++ D+G+PSL T+ V V + D NDNPPIF+ + + + E L+ +S
Sbjct: 433 KEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTIS 492
Query: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIK 1317
A+D D G N + Y + + F +D TGV+++S F E I T+
Sbjct: 493 --------ATDEDSGKNADIVYQL-GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVT 543
Query: 1318 ATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
A D+G PPL + + + + S F ++ F V E P VGVI+V
Sbjct: 544 ARDNGTPPLQSQAAVIVTVLDENDNSP---KFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1374 EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---RTIA 1430
G +I D D +F ++ +G I D ++S+Y V+ TDG R+
Sbjct: 601 AGENKAVTLSIL-NDND-NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1431 TQVHIFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYT 1484
+V I + ++N + P + T +++ VP +PG + V A+D D G + L YT
Sbjct: 659 AKVTI-NVMDVNDNSPVVISPPSNTSFKL-VPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 1485 IHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK-RNFVWVTI 1543
I + G LF++DP +G +T+ + + H L V + D P V V +
Sbjct: 717 IVSGNNKG---LFRIDPVTG-NITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFL 772
Query: 1544 HVED 1547
+V D
Sbjct: 773 YVND 776
Score = 212 bits (539), Expect = 7e-54
Identities = 190/752 (25%), Positives = 321/752 (42%), Gaps = 43/752 (5%)
Query: 2806 LTENMPVGT--SVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWI-TTLQE 2862
L EN+P+G + ++ I+ TG + YRL + G L + S +G I TT
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDA--PLVKVSSSTGEIFTTSNR 91
Query: 2863 LDCETC---QTYHFHVVAYDHGQTIQLSSQAL----VQVSITDENDNAPRFASEEYRGSV 2915
+D E +Y + + + L + +++ + D NDNAP F S S+
Sbjct: 92 IDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISI 151
Query: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV----GDEW-RISSRK 2970
EN+ D D Q + G + FG+ V G++W ++ ++
Sbjct: 152 PENTLINSRFPIPSATDPDTGFNGVQ-HYELLNGQSV--FGLDIVETPEGEKWPQLIVQQ 208
Query: 2971 TLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
LDRE Y++++ DG + ++ +++ V DVNDN P + + E+ G
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVG 268
Query: 3028 HFILKVSATDLDTDTNAQITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNL 3083
++++ ATD D +NA+I Y A F L+ TG +T +LDRE + +
Sbjct: 269 TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKV 328
Query: 3084 VAKATDGGGRSCQADITLHVEDVNDNAPRF------FPSHCAVAVFDNTTVKTPVAVVFA 3137
A+DG +A +T++V DVNDN P P + V + + V T +A++
Sbjct: 329 TVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388
Query: 3138 RDPDQGANAQVVYSLPDSAEGHF-SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPI 3196
D D N +V+ + H ++ ++ L + ASD G P
Sbjct: 389 SDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP- 447
Query: 3197 PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVV 3256
L+ V V + D P+F + V E+ G + ++ +
Sbjct: 448 SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
Query: 3257 SGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNE 3316
G F LD +TG+L + D E ++ ++ + L V+V + D N+
Sbjct: 508 LGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEND 567
Query: 3317 HRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKG 3376
+ P+F + + V EN + ++ TD D N +T S++ N +F + P G
Sbjct: 568 NSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND--NFVLDPYSG 625
Query: 3377 ELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTT-- 3434
++ + DREQ SSY+ ++ATD GQPP + I V DVNDN P +T+
Sbjct: 626 VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFK 685
Query: 3435 -VQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRR 3492
V ++ GS V ++ D D+ N + I GNN FR+ P G + E +
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAE-LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPT 744
Query: 3493 AQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
++L + SD G P L +L V ++V +
Sbjct: 745 DVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 202 bits (515), Expect = 5e-51
Identities = 176/624 (28%), Positives = 276/624 (44%), Gaps = 36/624 (5%)
Query: 2962 DEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVH 3021
D ++ + + E+ + L V F + ++I V D NDN+P + +
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIP 152
Query: 3022 EDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTGELTTLTALD 3074
E+ SATD DT N Y L G F LD +L LD
Sbjct: 153 ENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQQNLD 211
Query: 3075 RERKDVFNLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPV 3132
RE+KD + + K DGG +S A + + V DVNDN P F V + +N V T V
Sbjct: 212 REQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSV 271
Query: 3133 AVVFARDPDQGANAQVVY----SLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
+ A D D G+NA++ Y + + + F+++ TTG+I +++ L A ++TV
Sbjct: 272 IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVL 331
Query: 3189 ASDLGTPIPLSTLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLAT 3242
ASD G+ P TVT++V + D P + +V + E P T++ L T
Sbjct: 332 ASD-GSSTPARA--TVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA-LIT 387
Query: 3243 LTRPGAEKTGYRVVSGNEQGRFRLDA---RTGILYVNASLDFETSPKYFLSIECSRKSSS 3299
++ + G + + F L A +L ++ LD+E + ++ I S
Sbjct: 388 VSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
SL+ V V + D N++ P F Q V EN G + T+SATDED N+DI Y
Sbjct: 448 SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
Query: 3360 LIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADV 3419
L G F + K G L ++ DRE+ + + A D+G PPL + + V D
Sbjct: 508 L--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 3420 NDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP 3479
NDN P+F ++ V EN P S V + ++D D+ EN + ++ N+ F + P
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN---KAVTLSILNDNDNFVLDP 622
Query: 3480 -DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP---SALPLE 3535
G + + R Q Y ++A+D G PP SS V ++V + + +P S
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 3536 IFITVGEDEFQGGMVGKIHATDRD 3559
F V G +V ++ A D D
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVD 706
Score = 201 bits (510), Expect = 2e-50
Identities = 193/738 (26%), Positives = 328/738 (44%), Gaps = 101/738 (13%)
Query: 429 YQLHIRTSPGQASTVVVIDIV--DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486
++L + P ++ I I+ D N++AP+F + ++ EN + +ATD D
Sbjct: 111 FELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPD 170
Query: 487 HGENGYVTYSIAGPKALPFSIDPYLGIIST-----------SKPMDYELMKRIYTFRVRA 535
G NG Y + +++ F +D I+ T + +D E K Y +++
Sbjct: 171 TGFNGVQHYELLNGQSV-FGLD----IVETPEGEKWPQLIVQQNLDRE-QKDTYVMKIKV 224
Query: 536 SDWGSPFRREKEVSIFLQLR--NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE 593
D G+P +K + LQ+ ++NDN+P+F+E I ++ PVG S++ + A D D
Sbjct: 225 EDGGTP---QKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADI 281
Query: 594 LQNLKYEIVSGNEL-----EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNY 648
N + + G ++ F LN+ +G+I+++R +L + + + + ASDG +
Sbjct: 282 GSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQR---SLDREETAIHKVTVLASDGSST 338
Query: 649 AS--PTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706
+ T+N+T V D P D +++ T+
Sbjct: 339 PARATVTINVTDVNDN----PPNIDLRYIISPINGTVY---------------------- 372
Query: 707 INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766
+ E P+NT +A + +D D NGK++ I E F ++
Sbjct: 373 -----------------LSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLK 412
Query: 767 L---ETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG 823
LL ++ LDYE T + + D G P + L+ V ++D NDN P F
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQP 472
Query: 824 GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDR 883
+L++SE+ G + ++ D DS N + Y L F L TG L + DR
Sbjct: 473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 884 ESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTV 943
E + R+I V ARD + L S +I+T+ D NDNSP+ H + V E+LP +
Sbjct: 533 EEQERFIFTVTARDNGTP--PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYST 590
Query: 944 LTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASD 1003
+ + +D D G V +++ + F +D +G + D E+++ Y + A+D
Sbjct: 591 VGVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1004 GGRPLARRTLCHVEVIVLDVNEN----LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059
GG+P R + V + V+DVN+N + PP SF V ++ G+ V V A D
Sbjct: 650 GGQP-PRSSTAKVTINVMDVNDNSPVVISPPSNTSF---KLVPLSAIPGSVVAEVFAVDV 705
Query: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMI---QTLAPLDREFASYYWLTVLAVDRG-SV 1115
D+G++ EL+Y + +G F I+ TG I + AP D + L V D G
Sbjct: 706 DTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTD---VGLHRLVVNISDLGYPK 762
Query: 1116 PLSSVTEVYIEVTDANDN 1133
L ++ V++ V D N
Sbjct: 763 SLHTLVLVFLYVNDTAGN 780
Score = 199 bits (506), Expect = 5e-50
Identities = 187/688 (27%), Positives = 301/688 (43%), Gaps = 44/688 (6%)
Query: 2025 GVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTE 2084
G ++ E + EL V + N + + +++ ++D NDN P F I + T
Sbjct: 100 GASYAEENECFFELEVVILPNDFFRLIK---IKIIVKDTNDNAPMFPSPVINISIPENTL 156
Query: 2085 PGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRID-------PYLGDISLKKPFDYQALN 2137
SATD D G NG YE + F +D + +++ D + +
Sbjct: 157 INSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKD 216
Query: 2138 KYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQA 2195
Y +K+ DGGTP S + VTV N + P+F+ +V +PEN + T ++ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 2196 RSPE-----GLRLIYNI-VEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTA 2249
+ +R I+ V LF + TG++TV LD E H TV A+D +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGS 336
Query: 2250 LGSFSEATVEVLVEDVNDNPPTF------SQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
+ + ATV + V DVNDNPP S + T +SE P T + + SD+D+
Sbjct: 337 -STPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDV 395
Query: 2304 NRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGET 2363
N V I + K N E S++ LDYE + F K+ A D G P L
Sbjct: 396 NGKVICFIEREVPFHLKAVYDNQYLLETSSL--LDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 2364 LVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQ 2423
LV V + D NDNPP F QP E +VSE G + + A D DS + + Y + G
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPN 511
Query: 2424 DRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPE 2480
F ++ +G+++ + + + V A D ++ V + + N SP+
Sbjct: 512 ASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPK 571
Query: 2481 FQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIAT 2539
F + ++ ++EN + V + D D+G + +I+N ++ F ++P +G I +
Sbjct: 572 FTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND--NDNFVLDPYSGVIKS 629
Query: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQFKASEYTVS---I 2594
DRE + +K A DGG T K+ + D NDN P + S +
Sbjct: 630 NVSFDREQQSSYTFDVK--ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV 687
Query: 2595 QSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLEN 2654
+ S V +V A D D G NA++ Y++ + K + I+PVTG + +++ +
Sbjct: 688 PLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGN-NKGLFRIDPVTGNITLEEKPAPTDV 746
Query: 2655 QTLDFFIKAQD-GGPPHWNSLVPVRLQV 2681
+ D G P ++LV V L V
Sbjct: 747 GLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 196 bits (498), Expect = 4e-49
Identities = 190/689 (27%), Positives = 303/689 (43%), Gaps = 90/689 (13%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L +++IV D N+N P F S V + EN+ ++ + +A D D+G +G Y L
Sbjct: 125 LIKIKIIVKDTNDNA--PMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL 182
Query: 1073 AGTGLAAFSI-----NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
G + I + + LDRE Y + + D G+ SS + + V
Sbjct: 183 NGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNI---TSGNYMGF 1184
+D NDN P + I E+APVGTSV+QL A D D S ++ + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H +VTVL + S + + V + + DVNDNPP
Sbjct: 303 FALNNTTGLITVQRSLDREETAIH--KVTVLASDGSSTPARATVTINVTDVNDNPP---- 356
Query: 1245 KLFNVRLPERLSPVSPGPVYR------------LVASDLDEGLNGRVTYSIEDSDEEAFS 1292
N+ L +SP++ G VY + SD D +NG+V IE E F
Sbjct: 357 ---NIDLRYIISPIN-GTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIER--EVPFH 410
Query: 1293 IDLVTGVVSSSSTFTAGEYN-----ILTIKATDSGQPPLS--ASVRLHIEWIPWPRPSSI 1345
+ V T + +Y I A+DSG+P L+ A VR+ +E +
Sbjct: 411 LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE-----DENDN 465
Query: 1346 PLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD------------- 1392
P F++ +V E + R GL+ IS D+D
Sbjct: 466 PPIFNQPVIELSVSENN-------------RRGLYLTTISATDEDSGKNADIVYQLGPNA 512
Query: 1393 --FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQF 1448
FD+++ TG + +R D + + TV D G+ + +Q + + + + N + P+F
Sbjct: 513 SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF 572
Query: 1449 LETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVT 1508
++ V ++ + + D D G++ T+ D + F LDP SGV+ +
Sbjct: 573 THNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDPYSGVIKS 629
Query: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGN------LHPPRFTQLHYEA 1562
D S +T V D P + + VTI+V D N + PP T
Sbjct: 630 NVSFDREQ-QSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL-- 686
Query: 1563 SVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQAN 1622
VP + PG+ + +V A+D D G+NAE+ Y+++ GN++G F I+ + G ITL +K +
Sbjct: 687 -VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTD 745
Query: 1623 HAPHTLTVKAEDQGSPQ-WHDLATVIIHV 1650
H L V D G P+ H L V ++V
Sbjct: 746 VGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 191 bits (485), Expect = 1e-47
Identities = 192/752 (25%), Positives = 319/752 (42%), Gaps = 85/752 (11%)
Query: 1457 VPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSG-VLVTVGKLD-- 1513
VP +P + L + I+ G S G A L ++ S+G + T ++D
Sbjct: 38 VPIGNIP--KDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 1514 -LGSGPSQHTLTVMVRDQEIPIKRN----FVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
L +G S + E+ I N + + I V+D N + P F S+P+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENT 155
Query: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNI-----NALLGIITLAQKLDQANH 1623
+ A D D G N HY LL G S +I + + Q LD+
Sbjct: 156 LINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQK 215
Query: 1624 APHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVS 1683
+ + +K ED G+PQ A + + V + + P+F + + V IPE+ PVG+ ++ +
Sbjct: 216 DTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLH 275
Query: 1684 AM-----SPSEVTY----ELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSN 1734
A S +E+ Y ++ K +F++N+ +GLI+ Q+ LD E+ + +++ + S+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATK-RLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 1735 MAGAFTDVMVVVDIIDENDNAP----MFLKSTFVGQI--SEAAPLYSMIMDKNNNPFVIH 1788
+ V +++ D NDN P ++ S G + SE P+ N +I
Sbjct: 335 GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPV-------NTKIALIT 387
Query: 1789 ASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP 1848
SD D + N ++ I + + L S +DYE F F + D G P
Sbjct: 388 VSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 1849 VLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK 1908
L + A V + + D ND+PP F++ + E+++ G+ L + A+DEDS
Sbjct: 448 SL--NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS------- 498
Query: 1909 TGNADEAVTIHPVTGSISVLNPAFLGLSRK-------------------LTIRASDG--- 1946
NAD + P N +F L RK T+ A D
Sbjct: 499 GKNADIVYQLGP--------NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTP 550
Query: 1947 LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYF 2004
Q A V +++ D S +F + + V ENL + ++ N ++
Sbjct: 551 PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLS 610
Query: 2005 LLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
+LN D F + +GV+++ V+FDREQQ ++ V+ D P R + V +++ DVN
Sbjct: 611 ILNDNDNFVLDPYSGVIKS-NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVN 669
Query: 2065 DNPPKFKHLPYYT---IIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF--AEDYTYFRID 2119
DN P P T ++ PG V+ +V A D D G N + Y + FRID
Sbjct: 670 DNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRID 729
Query: 2120 PYLGDISLKKPFDYQALNKYHLKVIARDGGTP 2151
P G+I+L++ + + L V D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 180 bits (457), Expect = 2e-44
Identities = 168/670 (25%), Positives = 303/670 (45%), Gaps = 51/670 (7%)
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG-N 1180
++ I V D NDN P V SI E+ + + A DPD+ G + + +G +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 1181 YMGFFMIHPVTG----LLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236
G ++ G L Q LDRE KD +++++ V D G P ST+ + V + DVN
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
Query: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTY----SIEDSDEEAFS 1292
DN P+F V +PE +PV V +L A+D D G N + Y + + + F+
Sbjct: 247 DNRPVFKEGQVEVHIPEN-APVGTS-VIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 1293 IDLVTGVVSSSSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFD 1350
++ TG+++ + E I +T+ A+D P A+V +++ + P +I L +
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVN-DNPPNIDLRYI 363
Query: 1351 ETYYSFTVM--ETDPVNHMVGVISVEGRPGLFWFNISGG-----DKDMDFDIEKTTGSIV 1403
+ + TV E DPVN + +I+V + +++G ++++ F ++ +
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDT----DVNGKVICFIEREVPFHLKAVYDNQY 419
Query: 1404 IARP---LDTRRRSNYNLTVEVTDGSRTIATQVHIFMIA--NINHHRPQFLETRYEVRVP 1458
+ LD ++ + +D + Q + + + N + P F + E+ V
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVS 479
Query: 1459 QDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGS 1516
++ G+ L + A D+D GK+ ++Y + + AS F LD +GVL T ++
Sbjct: 480 ENNRRGLYLTTISATDEDSGKNADIVYQLGPN-----ASFFDLDRKTGVL-TASRVFDRE 533
Query: 1517 GPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQ 1576
+ TV RD P ++ V + V D N + P+FT H++ V + + + +
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 1577 VRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQG 1636
+ DAD G N V S+L N F ++ G+I D+ + +T VKA D G
Sbjct: 594 ITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1637 SPQWHDLATVIIHVYPSDRSAPIF---SKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
P A V I+V + ++P+ + F +P S GS + V A+ +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA---GAFTDVMVV 1745
E+ Y + GN G+F ++ +G I+ ++K + ++L + S++ T V+V
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771
Query: 1746 VDIIDENDNA 1755
+ + D NA
Sbjct: 772 LYVNDTAGNA 781
Score = 174 bits (442), Expect = 1e-42
Identities = 199/768 (25%), Positives = 333/768 (43%), Gaps = 98/768 (12%)
Query: 1668 EIPESIPVGS-----PILLVSAMSPSEVTYELREGNKDG---VFSMNSYSG-LISTQKKL 1718
E+PE++P+G+ I ++A + + + R +K G + ++S +G + +T ++
Sbjct: 33 ELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 1719 DHEKI---SSY----------QLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
D EK+ +SY ++ I ++ F + + + + D NDNAPMF
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDF---FRLIKIKIIVKDTNDNAPMF------- 142
Query: 1766 QISEAAPLYSMIMDKN---NNPFVI-HASDSDKEANSLLVYKILEPEALKFFKID----- 1816
+P+ ++ + +N N+ F I A+D D N + Y++L +++ F +D
Sbjct: 143 ----PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV--FGLDIVETP 196
Query: 1817 --PSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874
L + +D E ++ + V D G+P + QV V DVND+ P F E
Sbjct: 197 EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT--VSDVNDNRPVFKE 254
Query: 1875 QIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK-------TGNADEAVTIHPVTGSISV 1927
EV I G ++ + A+D D N I+ ++ TG I+V
Sbjct: 255 GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 1928 LNPAFLGLSR------KLTIRASDGLYQDT-ALVKISLTQVLDKSLQFD--------QDV 1972
L R K+T+ ASDG A V I++T V D D
Sbjct: 315 QR----SLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 1973 YWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHM---VQSAGVLQTRGVAFD 2029
+ + K+ + + AL+ + + +N + F+ FH+ + +L+T + D
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETSSL-LD 428
Query: 2030 REQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVL 2089
E + D+ P LVRV +ED NDNPP F + + G L
Sbjct: 429 YEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 2090 FQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
+SATDED G N + Y+ + ++F +D G ++ + FD + ++ V ARD G
Sbjct: 489 TTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNG 548
Query: 2150 TPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLYTP---ILHTQARSPEGLRLI 2204
TP LQS+ V+VTV N ++P F +++ V EN+ Y+ I T A + E +
Sbjct: 549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVT 608
Query: 2205 YNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVE 2263
+I+ + F D +GV+ D E ++ + F V+ATD S A V + V
Sbjct: 609 LSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVM 666
Query: 2264 DVNDNPPTFSQLVYTTSIS----EGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVS 2319
DVNDN P TS +P V ++ A D D+G N ++ Y IV +
Sbjct: 667 DVNDNSPVVISPPSNTSFKLVPLSAIPGSV-VAEVFAVDVDTGMNAELKYTIVSGNN--K 723
Query: 2320 KFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVV 2367
F+I+ TG + T++E H V + P + TLV+V
Sbjct: 724 GLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
Score = 161 bits (408), Expect = 1e-38
Identities = 143/546 (26%), Positives = 253/546 (46%), Gaps = 47/546 (8%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + I+ + ++ T ++ V + D ND +P+F V I E+ P+ +
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 166 PICKVTATDADLGQNAEFYYAFNTR-----SEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G NAE Y F + +FA++ T+G++TV L+ H++
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDAN 280
VLA S+G+ + A + ++V PP I + P + GT Y L + +
Sbjct: 330 VLA-------SDGSSTPARATVTINVTDVNDNPPNIDLRYIISPIN--GTVY---LSEKD 377
Query: 281 SSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM---------EYLHGFNL 331
++ + V D + K I R F L +V D ++ E F+
Sbjct: 378 PVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437
Query: 332 SLQARSGSGPYF-YSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAF 390
+ A P + + L + F + V + +SE + G + + T
Sbjct: 438 KIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDED 497
Query: 391 P----NLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQAS 441
++ Y L P++ F L+ +TG++T +++ D ++ + + T P Q+
Sbjct: 498 SGKNADIVYQLGPNASF--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQ 555
Query: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
V++ ++D N+++P F + + + EN+P ++V +T TD D GEN VT SI
Sbjct: 556 AAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN 615
Query: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
F +DPY G+I ++ D E + YTF V+A+D G P R + + + ++NDN
Sbjct: 616 D-NFVLDPYSGVIKSNVSFDRE-QQSSYTFDVKATDGGQP-PRSSTAKVTINVMDVNDNS 672
Query: 562 PMFEEVNCTGSIR---QDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFS 616
P+ S + G + + A+DVD N LKY IVSGN F ++ +
Sbjct: 673 PVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
Query: 617 GVISLK 622
G I+L+
Sbjct: 733 GNITLE 738
Score = 159 bits (403), Expect = 4e-38
Identities = 168/640 (26%), Positives = 280/640 (43%), Gaps = 58/640 (9%)
Query: 3031 LKVSATDLDTDTNAQITYSLHGPG--AHEFKLDPHTGEL-TTLTALDRERKDVFNLVAKA 3087
L +S + T T+A + Y L A K+ TGE+ TT +DRE+ L A A
Sbjct: 47 LNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREK-----LCAGA 101
Query: 3088 TDGGGRSCQAD---------------ITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPV 3132
+ C + I + V+D NDNAP F +++ +NT + +
Sbjct: 102 SYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRF 161
Query: 3133 AVVFARDPDQGANAQVVYSLPD--SAEGHFSIDATTGV----IRLEKPLQVRPQAPLELT 3186
+ A DPD G N Y L + S G ++ G + +++ L + +
Sbjct: 162 PIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMK 221
Query: 3187 VRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP 3246
++ D GTP ST + V+V + D PVF + V +PE+AP GT V+QL
Sbjct: 222 IKVEDGGTPQKSST-AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDAD 280
Query: 3247 GAEKTGYRVVSGNE-----QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSL 3301
R + G + + F L+ TG++ V SLD E + + +++ S SS+
Sbjct: 281 IGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA 340
Query: 3302 SDVTTVMVNITDVNEHRP----QFPQDPYSTRVL--ENALVGDVILTVSATDEDGPLNSD 3355
TV +N+TDVN++ P ++ P + V E V I ++ +D+D +N
Sbjct: 341 R--ATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGK 398
Query: 3356 ITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQ 3415
+ + ++ + L+ + LD E +S K+ A+DSG+P L++ + ++
Sbjct: 399 VICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVK 458
Query: 3416 VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAF 3475
+ D NDNPP F Q +V EN+ G + + +D DS +N G N S F
Sbjct: 459 LEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA---DIVYQLGPNASFF 515
Query: 3476 RVTPDGWLVTAEGL-SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPL 3534
+ ++TA + R QE + + A D+G PPL S +V V V +++ +P
Sbjct: 516 DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHN 575
Query: 3535 EIFITVGEDEFQGGMVGKIHATDRDPQD--TLTYSLAEEETLGRHFSVGAPDGKIIAAQG 3592
V E+ + VG I TD D + +T S+ + +F + G I +
Sbjct: 576 HFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND---NFVLDPYSGVIKSNVS 632
Query: 3593 LPR---GHYSFNVTVSDG---TFTTTAGVHVYVWHVGQEA 3626
R Y+F+V +DG ++TA V + V V +
Sbjct: 633 FDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Score = 120 bits (300), Expect = 4e-26
Identities = 165/715 (23%), Positives = 291/715 (40%), Gaps = 86/715 (12%)
Query: 131 LTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTR 190
L ++ + + D ND P+F P ++I E+ + S +ATD D G N +Y
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
Query: 191 SEMFAIHPTSGVVTVAGK----LNVTWRGKHELQVLAVDRMRKISEGNG--FGSLAALVV 244
+F + V T G+ L V E + V ++ K+ +G S A L V
Sbjct: 185 QSVFGLDI---VETPEGEKWPQLIVQQNLDREQKDTYVMKI-KVEDGGTPQKSSTAILQV 240
Query: 245 HVEPALRKPPAIASVVVT---PPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFK 301
V P V P ++ GT+ + G+ E + G K
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 302 AIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIR-----GFHLPPSK 356
+ +A +N L++V+ E +++ A GS + + PP+
Sbjct: 301 RL--FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNI 358
Query: 357 LSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPSSENVGFKLNA---RT 412
V LSE P +++ ++ V+ ++ V+ V F L A
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 413 GLITTTKLMDFHDRAHYQLHIRTS----PGQASTVVV-IDIVDCNNHAPLFNRSSYDGTL 467
L+ T+ L+D+ + I S P T +V + + D N++ P+FN+ + ++
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSV 478
Query: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
EN G + ++ATD D G+N + Y + GP A F +D G+++ S+ D E +R
Sbjct: 479 SENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKTGVLTASRVFDREEQER 537
Query: 528 IYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMS 587
+ F V A D G+P + + ++ + + + NDN P F + + ++ P ++ ++
Sbjct: 538 -FIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 588 AIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKN 647
D D +N + N+ + F L+ +SGVI ++ Q +SY+ + A+DG
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSN---VSFDREQQSSYTFDVKATDGGQ 652
Query: 648 YASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQ 706
+T +T+ V D + PV V++ + T +
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPV------VISPPSNTSFKLV------------------- 687
Query: 707 INHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIE 766
L ++P + +A + A D D G N +L Y I GN +G F I+
Sbjct: 688 -----------------PLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRID 729
Query: 767 LETGLLTV---AAPLDYEATNFYILNVTVYDLGTPQK-SSWKLLTVNVKDWNDNA 817
TG +T+ AP D + L V + DLG P+ + L+ + V D NA
Sbjct: 730 PVTGNITLEEKPAPTD---VGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA 781
Score = 63.5 bits (153), Expect = 4e-09
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 18/261 (6%)
Query: 106 LLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLK 164
+ +RE ++ + + A + T L++ V+V +LD+ND P F+ ++ +SE++P
Sbjct: 529 VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588
Query: 165 SPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAV 224
S + +T TDAD G+N + ++ F + P SGV+ + + + V A
Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 225 DRMRKISEGNGFGSLAALVVH-VEPALRKPPAIASVVVTPPDSNDGTTYATVL-VDANSS 282
D + ++ + V+ P + PP+ S + P + G+ A V VD ++
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
Query: 283 -GAEVESVEVVGG-------DPGKHFKAIKSYARSNEFSL----VSVKDINWMEYLHGF- 329
AE++ V G DP ++ + L V++ D+ + + LH
Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Query: 330 --NLSLQARSGSGPYFYSQIR 348
L + +G+ Y Y IR
Sbjct: 769 LVFLYVNDTAGNASYIYDLIR 789
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 248 bits (633), Expect = 9e-65
Identities = 199/664 (29%), Positives = 300/664 (45%), Gaps = 34/664 (5%)
Query: 2763 YQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAI 2822
Y+++V + ++ LV + + D+NDN P+F A + EN + + A+
Sbjct: 140 YEVEV---AILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV 196
Query: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESG----WITTLQELDCETCQTYHFHVVAY 2878
D D G +G +Y L N+ L I++ G + +ELD E TY V
Sbjct: 197 DPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVE 254
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
D G Q SS A++QVS+TD NDN P F E S+ EN+ G V L DADI E
Sbjct: 255 DGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGEN 313
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-ASVTV 2997
+ + + + I+ ++ LDRE T + L V ASDG A V
Sbjct: 314 AKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMV 373
Query: 2998 EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI------LKVSATDLDTDTNAQITYSLH 3051
+ V DVNDN P V++ V I ++ TD D D N ++T
Sbjct: 374 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD 433
Query: 3052 GPGAHE--FKLDPHTGE---LTTLTALDRERKDVFNLVAKATDGGGRSCQ--ADITLHVE 3104
HE F+L P L LD E + + A D G A + + V+
Sbjct: 434 ----HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Query: 3105 DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDA 3164
D NDNAP F S V++ +N + + V A D D G NA++ Y L A FS+D
Sbjct: 490 DENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR 549
Query: 3165 TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS 3224
TG++ + K L + T+ A D G P PL++ TV VS++ D PVF + E+
Sbjct: 550 RTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 608
Query: 3225 VQVPEDAPPGTEVLQLATLTRPG-AEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFET 3283
VPE+ P V L T+T P + + + +E F +D++TG++ N S D E
Sbjct: 609 FYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 667
Query: 3284 SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR---VLENALVGDVI 3340
Y ++ S S V +N+ DVN+++P F PY+ VL + G V+
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 727
Query: 3341 LTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
V A D D +N+++ YS++GGN F I + G + + + D + + ++A D
Sbjct: 728 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 787
Query: 3401 SGQP 3404
GQP
Sbjct: 788 LGQP 791
Score = 247 bits (630), Expect = 2e-64
Identities = 199/637 (31%), Positives = 303/637 (47%), Gaps = 43/637 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVY-VIADGNEEGCFDIELETG----LLTVA 775
+I + E+ IN+ AA DPD G NG Y +I N G IE G L V
Sbjct: 177 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQ 236
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ V V D G PQ+SS +L V+V D NDN P F +++I E+ V
Sbjct: 237 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 296
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD +N ++ ++ + F L+ TG + + LDRE P +
Sbjct: 297 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 356
Query: 891 LKVEARD---QPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPG 941
L V A D P++ L +VT DVNDN P + + + + E++P
Sbjct: 357 LLVLASDGGLMPARAMVLVNVT-------DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV-DLMTGALILERE--LDFERRAGYNLS 998
T + + +D D G R FR+ + + +LE LD+E Y +
Sbjct: 410 TKIALITVTDKDADHNG--RVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
L A+D G+P ++ + + V D N+N P SFV + NSP G Q++ V+A D
Sbjct: 468 LLAADAGKPPLNQS-AMLFIKVKDENDNA-PVFTQSFVTVSIPENNSP-GIQLMKVSATD 524
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSG + E+ Y L FS+++ TGM+ + LDRE Y T+LA D G PL+
Sbjct: 525 ADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT 583
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
S V++ + D NDN P + + + E+ P +V + DPD +T +I
Sbjct: 584 SNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILD 643
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
N F I TG++ DRE ++ + V D G S S+++V + ++DVNDN
Sbjct: 644 EN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDN 701
Query: 1239 PPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLV 1296
P+F +N L +PG V++++A D D G+N V YSI + + F+ID
Sbjct: 702 KPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQE 761
Query: 1297 TG---VVSSSSTFTAGEYNILTIKATDSGQPPLSASV 1330
TG ++ G + +L +KA D GQP SV
Sbjct: 762 TGNITLMEKCDVTDLGLHRVL-VKANDLGQPDSLFSV 797
Score = 246 bits (629), Expect = 3e-64
Identities = 207/705 (29%), Positives = 326/705 (46%), Gaps = 38/705 (5%)
Query: 2253 FSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
F + L+ED+NDN P F V SI E + A D D G N +Y+++
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 2313 ED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVN 2368
+ G DV + + ++ +ELD E + + +KV+ D G P + ++ V+
Sbjct: 212 KSQNIFGLDVIETPE-GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 2369 VSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDR 2425
V+D NDN P F++ + E ++ E A G V ++ A D D + +++ + ++S R
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQH 2484
F +N+++G+I++ + ++ L V ASD G+ A V +N T+ N P
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390
Query: 2485 LY------EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNG-QI 2537
L+EN + TK+ + DKD+ G + +++ + N +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 2538 ATLQKLDRENSTERVIAIKVMARDGG----GRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
LD E++ E AIK++A D G + A +K+ DENDN P F S TVS
Sbjct: 451 ENAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 506
Query: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE 2653
I N S +++V A DAD G NA++ Y + P+ ++ TG++ V L +
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRTGMLTVVKKLDREK 564
Query: 2654 NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV 2713
F I A+D G P S V V + ++ + + P F+ Y F PE+LP +G++
Sbjct: 565 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624
Query: 2714 KAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
V D S V + + N D F++D TGVI+ D E + Y V A
Sbjct: 625 -TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 681
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
S V I V DVNDN+PVF P Y+ VL P GT V QV A+D DTG +
Sbjct: 682 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMN 740
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
+V Y + G N +LFAID E+G IT +++ D + V A D GQ L S
Sbjct: 741 AEVRYSI---VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSV 797
Query: 2890 ALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
+V + + + NA +E R S+ P +A + + +D
Sbjct: 798 VIVNLFVNESVTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 238 bits (607), Expect = 1e-61
Identities = 187/702 (26%), Positives = 322/702 (45%), Gaps = 32/702 (4%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH 869
++D NDNAP FP ++I E++ + + D D NG Y L+ F L
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 870 PL-------TGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNS 922
+ +L+V LDRE + Y++KV+ D Q S L +++ D NDN
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNH 278
Query: 923 PQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY----VLMDGAHGTFRVDLMT 978
P + +PE+ P GT +T L A+D D+G ++ + ++ + A F ++ T
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
G + ++ LD E + L + ASDGG AR V V V DVN+N+ V+
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNP 395
Query: 1039 GQ----VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
+ EN P T++ ++ D D+ +G + F + + +++ A
Sbjct: 396 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455
Query: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
LD E Y + +LA D G PL+ ++I+V D NDN P +Q+ SI E+ G
Sbjct: 456 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 515
Query: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
++++ A D DS ++ + + + F + TG+L+ ++LDRE +D+++ +
Sbjct: 516 QLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
DNG P L S V V I+D NDN P+F+H + +PE L G V + +D D G
Sbjct: 575 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP--RHGTVGLITVTDPDYG 632
Query: 1275 LNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPLSASVRL 1332
N VT SI D +++ F+ID TGV+ + +F + T +KA D G+ S+S ++
Sbjct: 633 DNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 1333 HIEWIPWPRPSSIPLAFDETY-YSFTVMETDPVNHMVGVISVEGRPGL---FWFNISGGD 1388
I + + + Y Y + T+P + VI+V+ G+ ++I GG+
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 1389 KDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSR--TIATQVHIFMIANINHHRP 1446
F I++ TG+I + D + + V+ D + ++ + V + + N +
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Query: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGS 1488
+ + P E+ V + D K L+ + G+
Sbjct: 812 TLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853
Score = 223 bits (568), Expect = 3e-57
Identities = 193/633 (30%), Positives = 293/633 (46%), Gaps = 58/633 (9%)
Query: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI-------YSL 2726
LV +R + + P F + S PE+ S+ + AV DP + Y L
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV---DPDVGINGVQNYEL 210
Query: 2727 VRGT---------TPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
++ TPE +K + V+K +D E Y + V
Sbjct: 211 IKSQNIFGLDVIETPEGDK---------MPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 261
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
S + + V D NDN PVF+ + + EN PVGTSV Q+ A D D G + ++ + S
Sbjct: 262 SSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 321
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSIT 2897
+ LF +++ +G IT + LD E + V+A D G + ++A+V V++T
Sbjct: 322 NLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVT 378
Query: 2898 DENDNAP----RFASEEYRGSVV--ENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
D NDN P R+ +VV EN +A + D D ++ N +VTC+ P
Sbjct: 379 DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD-ADHNGRVTCFTDHEIP 437
Query: 2952 LGQFGISQV-GDEWRISSRKTLDREHTAKYLLRVTASD-GK--FQASVTVEIFVLDVNDN 3007
F + V +++ + + LD E T +Y +++ A+D GK S + I V D NDN
Sbjct: 438 ---FRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 494
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
+P +Q T + E+ PG ++KVSATD D+ NA+I Y L EF LD TG L
Sbjct: 495 APVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 554
Query: 3068 TTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDN 3125
T + LDRE++D + A D G +++T+ V D NDN+P F + V +N
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 614
Query: 3126 TTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL 3185
V ++ DPD G N+ V S+ D + F+ID+ TGVIR Q
Sbjct: 615 LPRHGTVGLITVTDPDYGDNSAVTLSILDEND-DFTIDSQTGVIRPNISFDREKQESYTF 673
Query: 3186 TVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL----NTEHSVQVPEDAPPGTEVLQLA 3241
V+A D G + S+ VT++VV + D PVF+ N + + +P PGT V Q+
Sbjct: 674 YVKAED-GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVI 731
Query: 3242 TL---TRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ T AE Y +V GN + F +D TG
Sbjct: 732 AVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETG 763
Score = 218 bits (556), Expect = 8e-56
Identities = 209/756 (27%), Positives = 346/756 (45%), Gaps = 71/756 (9%)
Query: 872 TGELVVTG-HLDRES-------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
TGE+ TG +DRE + +VE P ++F + + +ED+NDN+P
Sbjct: 113 TGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAP 169
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM------ 977
+ +PE+ + T A DPD+G G Y L+ + F +D++
Sbjct: 170 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-SQNIFGLDVIETPEGD 228
Query: 978 -TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFV 1036
LI+++ELD E + Y + + DGG P R + ++V V D N+N P F
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDN--HPVFKETE 285
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYF---LRAGTGLAAFSINQDTGMIQTLA 1093
+ + EN+P GT V + A D D G + ++ + L + F +N TG+I
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMS-QAVFYP-----SIQ 1147
PLDRE + L VLA D G +P ++ V + VTD NDN P + + + P +
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG---LLSTAQQLDREN 1204
E+ P+ T + + D D+ G++T ++ F + PV LL A LD E+
Sbjct: 404 ENIPLNTKIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLENAAYLDYES 460
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY 1264
E+ +++ D G+P L ++ + + + D NDN P+F+ V +PE SP +
Sbjct: 461 TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLM 518
Query: 1265 RLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG---VVSSSSTFTAGEYNILTIKATDS 1321
++ A+D D G N + Y + FS+D TG VV +Y + TI A D+
Sbjct: 519 KVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKY-LFTILAKDN 577
Query: 1322 GQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRP 1377
G PPL+++V + + I S + F Y F V E P + VG+I+V G
Sbjct: 578 GVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 634
Query: 1378 GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVH 1434
+I D++ DF I+ TG I D ++ +Y V+ DG SR+ + +V
Sbjct: 635 SAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 692
Query: 1435 IFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGS 1488
I + ++N ++P F+ YE+ +P T PG + +V A+D D G + + Y+I G
Sbjct: 693 I-NVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 750
Query: 1489 QDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVED 1547
+ LF +D +G + + K D+ + H + V D P + V V + V +
Sbjct: 751 ---NTRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 806
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+ +L S+ + P TE+ V + +D
Sbjct: 807 SVTNATLINEL-VRKSIEAPVTPNTEIADVSSPTSD 841
Score = 209 bits (533), Expect = 4e-53
Identities = 197/716 (27%), Positives = 316/716 (44%), Gaps = 56/716 (7%)
Query: 1997 LNDTLSYFLLNGTD---MFHMVQSAGVLQTRGVAFDREQ------QDTHELAVEVRDNRT 2047
L T+ + L+ T + + + G + T G DRE+ +D H EV
Sbjct: 89 LTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEH-CFYEVEVAIL 147
Query: 2048 PQRVAQGL-VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVT 2106
P + + + +R IED+NDN P F I + + +A D D+G NG
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 2107 YEFAEDYTYFRID-------PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE-- 2157
YE + F +D + + ++K D + + Y +KV DGG P S
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAIL 267
Query: 2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPI--LH-TQARSPEGLRLIY---NIVEEE 2211
+V VT N ++P+F+ +V +PEN + T + LH T A E ++ + N+V
Sbjct: 268 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI 327
Query: 2212 PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPT 2271
LF + TG++T+ PLD E H V A+D L + A V V V DVNDN P+
Sbjct: 328 ARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVLVNVTDVNDNVPS 386
Query: 2272 F------SQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
+ + T +SE +P T + + +D+D+ N V+ D + +
Sbjct: 387 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVF 444
Query: 2326 GSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYE 2385
+ + LDYE+ + + +K+ A D G PPL ++ + V D NDN P F Q
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 2386 ANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKH 2445
++ E + G ++KV A D DS + + YL L + F ++ +G++++ +
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYL-LGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 2446 LDSSYNLRVGASD-GV--FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID 2502
+ Y + A D GV + V V+++ + N SP F + Y+ + EN V
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623
Query: 2503 LLAIDKDSGPYGTIDYTIINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
+ D D G + +I+++ ++ F+I + G I DRE +K A D
Sbjct: 624 ITVTDPDYGDNSAVTLSILDE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED 679
Query: 2562 GG--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSP---VIQVLAYDADEGQ 2616
GG R + V I + D NDN P F Y S + + +P V QV+A D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 739
Query: 2617 NADVTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
NA+V YS+ N DL E +T + K + +GL +KA D G P
Sbjct: 740 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHR----VLVKANDLGQP 791
Score = 207 bits (526), Expect = 2e-52
Identities = 187/656 (28%), Positives = 295/656 (44%), Gaps = 37/656 (5%)
Query: 2458 DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTID 2517
D +FR V + + N +P F + + EN+ + +K A+D D G G +
Sbjct: 149 DEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 2518 YTIINKLASEKFSI--NPNG----QIATLQKLDRENSTERVIAIKVMARDGG--GRVAFC 2569
Y +I + P G Q+ ++LDRE V+ +KV DGG R +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKV--EDGGFPQRSSTA 265
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN--PE 2627
+++ +TD NDN P FK +E VSI N + V Q+ A DAD G+NA + +S +
Sbjct: 266 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325
Query: 2628 DLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKV- 2686
++ + + +N TG++ +K+ L E + A DGG ++V V + V V
Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 385
Query: 2687 --SLPKFSEPLY-TFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLD 2743
+ P+ T E++P ++I ++ V +D V T + +
Sbjct: 386 SIDIRYIVNPVNDTVVLSENIPLNTKIALI-TVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 2744 PDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
+ +++ +D+ESTK Y I ++A + + I+V D NDN PVF
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 2804 AVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQEL 2863
+ EN G +++V+A D D+G + +++Y L D F++D +G +T +++L
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE----FSLDRRTGMLTVVKKL 560
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E Y F ++A D+G L+S V VSI D+NDN+P F EY+ V EN
Sbjct: 561 DREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 619
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D + + + E D F I SQ G I + DRE Y
Sbjct: 620 TVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTG---VIRPNISFDREKQESYTF 673
Query: 2983 RVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSAT 3036
V A DG +S V I V+DVNDN P Y V PG + +V A
Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733
Query: 3037 DLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
D DT NA++ YS+ G + F +D TG +T + D + ++ KA D G
Sbjct: 734 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLG 789
Score = 201 bits (512), Expect = 1e-50
Identities = 181/660 (27%), Positives = 292/660 (44%), Gaps = 38/660 (5%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
++ I D NDNAP F + S+ ENS +D D+ Q I +
Sbjct: 157 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 216
Query: 2952 LGQFGI-SQVGDEW-RISSRKTLDREHTAKYLLRVTASDGKF---QASVTVEIFVLDVND 3006
G I + GD+ ++ +K LDRE Y+++V DG F ++ +++ V D ND
Sbjct: 217 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 276
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS----LHGPGAHEFKLDP 3062
N P + + E+ G + ++ ATD D NA+I +S + F L+
Sbjct: 277 NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNA 336
Query: 3063 HTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAP----RFF--PS 3116
TG +T LDRE L+ A+DGG +A + ++V DVNDN P R+ P
Sbjct: 337 TTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV----YSLPDSAEGHFSIDATTGVIRLE 3172
+ V + +N + T +A++ D D N +V + +P FS LE
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS-----NQFLLE 451
Query: 3173 KPLQVRPQAPLELTVR--ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ ++ E ++ A+D G P PL+ + + V D PVF + +V +PE+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 3231 APPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTGILYVNASLDFETSPKYFL 3289
PG ++++++ + G + F LD RTG+L V LD E KY
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLF 570
Query: 3290 SIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED 3349
+I L+ TV V+I D N++ P F + Y V EN + ++ TD D
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHED 3409
NS +T S++ N FTI + G ++ + DRE+ SY+ ++A D G+
Sbjct: 631 YGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 3410 TDIAIQVADVNDNPPRF----FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR 3465
+ I V DVNDN P F + +Y + +P G+ V Q+I D D+ N +
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA-EVRYS 746
Query: 3466 ITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
I GN F + + G + E +++ ++A+D G P L S+ V + V E
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 806
Score = 199 bits (505), Expect = 7e-50
Identities = 190/663 (28%), Positives = 294/663 (44%), Gaps = 44/663 (6%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L + ++ D+N+N P F + V + ENS ++ + AA D D G++G Y L
Sbjct: 154 LVKIRFLIEDINDNA--PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 1073 AGT---GLAAFSINQDTGMIQTLAP--LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
GL + M Q + LDRE Y + V D G SS + + V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF---NITSGNYMGF 1184
TD NDN P + SI E+APVGTSV QL A D D K+ F N+ S
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H L V D G + + + V+V + DVNDN P
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDI 389
Query: 1245 KLF------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT----YSIEDSDEEAFSID 1294
+ V L E + P++ + + +D D NGRVT + I FS
Sbjct: 390 RYIVNPVNDTVVLSENI-PLNT-KIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ 447
Query: 1295 LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
+ + + EY I + A D+G+PPL+ S L I+ + P+ F +++
Sbjct: 448 FLLENAAYLDYESTKEYAIKLL-AADAGKPPLNQSAMLFIK--VKDENDNAPV-FTQSFV 503
Query: 1355 SFTVMETDPVNHMVGVISV---EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
+ ++ E + + +S + P + G D +F +++ TG + + + LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 1412 RRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
+ Y T+ D G + + V +F+ I + N + P F Y+ VP++ +
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
+ D D G + T+ + F +D +GV+ D S +T V D
Sbjct: 624 ITVTDPDYGDNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQES-YTFYVKAED 679
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFT----QLHYEASVPDTIAPGTELLQVRAMDADRG 1585
+ + VTI+V D N + P F YE +P T PGT + QV A+D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTG 738
Query: 1586 VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+NAEV YS++ GN+ F I+ G ITL +K D + H + VKA D G P L +
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD--SLFS 796
Query: 1646 VII 1648
V+I
Sbjct: 797 VVI 799
Score = 195 bits (496), Expect = 7e-49
Identities = 190/760 (25%), Positives = 331/760 (43%), Gaps = 86/760 (11%)
Query: 1193 LLSTAQQLDREN------KDEHI---LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFS 1243
+ +T ++DRE +DEH +EV +L + + ++ I D+NDN P+F
Sbjct: 116 IFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAPLFP 172
Query: 1244 HKLFNVRLPERLSPVSPGPVYRLVAS-DLDEGLNGRVTYSIEDSDEEAFSIDLVTG---- 1298
+ N+ +PE + S Y L A+ D D G+NG Y + S + F +D++
Sbjct: 173 ATVINISIPENSAINSK---YTLPAAVDPDVGINGVQNYELIKS-QNIFGLDVIETPEGD 228
Query: 1299 -----VVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+V + ++ +K D G P S++ L + + F ET
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETE 285
Query: 1354 YSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMD---FDIEKTTGSIVIAR 1406
++ E PV V + G F+ S ++ F + TTG I I
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 1407 PLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV---- 1462
PLD N+ L V +DG A + + + ++N + P ++ RY V DTV
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPS-IDIRYIVNPVNDTVVLSE 404
Query: 1463 -----PGVELLRVQAIDQD-KGKSLIYTIHGSQDPGSASLFQLDP---SSGVLVTVGKLD 1513
+ L+ V D D G+ +T H F+L P + +L LD
Sbjct: 405 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-------FRLRPVFSNQFLLENAAYLD 457
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
S ++ + ++ D P + I V+D N + P FTQ S+P+ +PG +
Sbjct: 458 YES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 516
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
L++V A DAD G NAE++Y LL ++ F+++ G++T+ +KLD+ + T+ A+
Sbjct: 517 LMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
D G P TV + + + ++P+F+ +EY +PE++P + L++ P S
Sbjct: 576 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 635
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSY--QLKIRGSNMAGAFTDVMVVV 1746
VT + + N D F+++S +G+I D EK SY +K + V +
Sbjct: 636 AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 693
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN---PFVIHASDSDKEANSLLVYK 1803
+++D NDN P+F+ + Y +++ N F + A D+D N+ + Y
Sbjct: 694 NVVDVNDNKPVFIVPPYNYS-------YELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 746
Query: 1804 ILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP-VLFAPRPAQVIIHV 1862
I+ F ID G +T++ + D + + V +D G P LF+ V+I
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFS-----VVIVN 801
Query: 1863 RDVNDSPPRFS--EQIYEVAIVGPIHPGMELLMVRASDED 1900
VN+S + ++ +I P+ P E+ V + D
Sbjct: 802 LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 180 bits (457), Expect = 2e-44
Identities = 154/580 (26%), Positives = 252/580 (43%), Gaps = 30/580 (5%)
Query: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
+ R+ Y + V + V + + D+NDN+P + + E+
Sbjct: 132 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 191
Query: 3032 KVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVA 3085
+A D D N Y L G E +L LDRE KD + +
Sbjct: 192 LPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKV 251
Query: 3086 KATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
K DGG RS A + + V D NDN P F + V++ +N V T V + A D D G
Sbjct: 252 KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 311
Query: 3144 ANAQVVYS----LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
NA++ +S + + A F ++ATTG+I +++PL +L V ASD G +
Sbjct: 312 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MP 368
Query: 3200 TLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGY 3253
V V+V + D +P + +V + E+ P T++ L T+T A+ G
Sbjct: 369 ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIA-LITVTDKDADHNGR 427
Query: 3254 RVVSGNEQGRFRLD---ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVN 3310
+ + FRL + +L A LD+E++ +Y + + + L+ + +
Sbjct: 428 VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 487
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D N++ P F Q + + EN G ++ VSATD D N++I Y L+G + F+
Sbjct: 488 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFS 546
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ + G L V K LDRE+ Y + A D+G PPL + + + + D NDN P F
Sbjct: 547 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 606
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE-GL 3489
Y V EN P V + ++DPD +N + ++ + F + ++
Sbjct: 607 YKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 3490 SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
R QE Y ++A D G SS V ++V + + P
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 703
Score = 171 bits (434), Expect = 1e-41
Identities = 155/531 (29%), Positives = 244/531 (45%), Gaps = 37/531 (6%)
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHF 3160
+ED+NDNAP F + +++ +N+ + + + A DPD G N Y L S G
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 3161 SIDATTG----VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP 3216
I+ G + ++K L + + V+ D G P ST + VSV D P
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHP 279
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYR-----VVSGNEQGRFRLDARTG 3271
VF TE V +PE+AP GT V QL E +VS + F L+A TG
Sbjct: 280 VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG 339
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP----QFPQDPYS 3327
++ + LD E +P + L + S + V+VN+TDVN++ P ++ +P +
Sbjct: 340 LITIKEPLDREETPNHKLLVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVN 397
Query: 3328 TRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
V+ EN + I ++ TD+D N +T + + L+ A LD
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 457
Query: 3386 REQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKV 3445
E Y++KL A D+G+PPL++ + I+V D NDN P F Q + ++ EN+ G ++
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 517
Query: 3446 LQLILSDPDSPENGPPYSFRITKGNNG----SAFRVTPDGWLVTAEGLSRRAQEWYQLQI 3501
+++ +D DS GP G + S R T G L + L R ++ Y I
Sbjct: 518 MKVSATDADS---GPNAEINYLLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTI 572
Query: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQ 3561
A D+G+PPL+S +V V + +Q+ +P E V E+ + G VG I TD D
Sbjct: 573 LAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 632
Query: 3562 D--TLTYSLAEEETLGRHFSVGAPDGKI---IAAQGLPRGHYSFNVTVSDG 3607
D +T S+ +E F++ + G I I+ + Y+F V DG
Sbjct: 633 DNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680
Score = 169 bits (427), Expect = 7e-41
Identities = 181/720 (25%), Positives = 298/720 (41%), Gaps = 98/720 (13%)
Query: 425 DRAHYQLHIRTSPGQASTVVVID--IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
+ Y++ + P + +V I I D N++APLF + + ++ EN + A
Sbjct: 136 EHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 195
Query: 483 TDRDHGENGYVTYSIAGPKALPFSIDPY-------LGIISTSKPMDYELMKRIYTFRVRA 535
D D G NG Y + + + F +D + + K +D E K Y +V+
Sbjct: 196 VDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDRE-EKDTYVMKVKV 253
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + + NDN P+F+E SI ++ PVG S+ + A D D +
Sbjct: 254 EDGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 596 NLKYE-----IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNY 648
N K +VS F LN +G+I++K P L + ++ L + ASDG
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP---LDREETPNHKLLVLASDGGLMPA 369
Query: 649 ASPTTLNITVVKD--PHFEV-----PVT------------------------CDKTGVLT 677
+ +N+T V D P ++ PV D G +T
Sbjct: 370 RAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT 429
Query: 678 QFTKTILHF---------IGLQNQESSDEEFTSLSTYQI--------------------- 707
FT + F L+N D E T ++
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Query: 708 --NHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEGCFD 764
N P F F ++ + E+ L +++ATD D+G N ++ Y++ D E F
Sbjct: 490 DENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FS 546
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
++ TG+LTV LD E + Y+ + D G P +S + V++ D NDN+P F
Sbjct: 547 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 606
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Y+ + E+ T+ +T D D DN V ++L + F++ TG + DRE
Sbjct: 607 YKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE 666
Query: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP---PG 941
+ Y V+A D S + I + DVNDN P I LP PG
Sbjct: 667 KQESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLW 1000
TV+ + A D D G EVRY ++ G F +D TG + L + D + + +
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVK 784
Query: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
A+D G+P +L V ++ L VNE++ + + + ++ T++ V++ D
Sbjct: 785 ANDLGQP---DSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 152 bits (383), Expect = 9e-36
Identities = 139/542 (25%), Positives = 245/542 (45%), Gaps = 40/542 (7%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + ++ + + T ++ V + D ND P+F V+I E+ P+ +
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G+NA+ +++F N +F ++ T+G++T+ L+ H+L
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP-------DSNDGTTYA 273
VLA S+G + A ++V+V P+I + P N
Sbjct: 359 VLA-------SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 411
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
L+ A+ D F+ + SN+F L + +++ L
Sbjct: 412 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVF--SNQFLLENAAYLDYESTKEYAIKLL 469
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA--FP 391
A +G P S + + ++ F ++ V + E + PG +++ V T A P
Sbjct: 470 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 392 N--LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVV 444
N + Y+L P + F L+ RTG++T K +D Y I P ++ V
Sbjct: 530 NAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 588
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP 504
+ I+D N+++P+F + Y + EN+P +V +T TD D+G+N VT SI
Sbjct: 589 FVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND-D 647
Query: 505 FSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMF 564
F+ID G+I + D E + YTF V+A D G R + + + ++NDN+P+F
Sbjct: 648 FTIDSQTGVIRPNISFDRE-KQESYTFYVKAED-GGRVSRSSSAKVTINVVDVNDNKPVF 705
Query: 565 EEVNCTGSIRQDWP---VGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
S P G + + A+D D N ++Y IV GN + F ++ +G I
Sbjct: 706 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI 765
Query: 620 SL 621
+L
Sbjct: 766 TL 767
Score = 148 bits (374), Expect = 1e-34
Identities = 164/670 (24%), Positives = 279/670 (41%), Gaps = 67/670 (10%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL-REGNKDGVFSMNSYS 1709
+AP+F + + IPE+ + S L +A+ P YEL + N G+ + +
Sbjct: 167 NAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPE 226
Query: 1710 G----LISTQKKLDHEKISSYQLKIRGSNMAGAF----TDVMVVVDIIDENDNAPMFLKS 1761
G + QK+LD E+ +Y +K++ + G F + ++ V + D NDN P+F ++
Sbjct: 227 GDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNHPVFKET 284
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYK---ILEPEALKFFKIDPS 1818
I E AP+ + + +HA+D+D N+ + + ++ A + F ++ +
Sbjct: 285 EIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 337
Query: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
G +TI +D E P+ + V D G P A V+++V DVND+ P +
Sbjct: 338 TGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY-- 391
Query: 1879 VAIVGPIHPGM----------ELLMVRASDEDSEVNYSIKTGNADEA-VTIHPVTGSISV 1927
IV P++ + ++ ++ +D+D++ N + E + PV + +
Sbjct: 392 --IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 1928 L-NPAFLGLS-------RKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
L N A+L + L A +A++ I + D + F Q ++ E
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 509
Query: 1980 NLQDRKALVILGAQGNHLNDTLSYFLLNGTDM---FHMVQSAGVLQTRGVAFDREQQDTH 2036
N L+ + A L G D F + + G+L T DRE++D +
Sbjct: 510 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML-TVVKKLDREKEDKY 568
Query: 2037 ELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ +DN P + V VSI D NDN P F H Y + + + ++ TD
Sbjct: 569 LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 628
Query: 2097 EDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSE 2156
D G N AVT ++ F ID G I FD + Y V A DGG S S
Sbjct: 629 PDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 2157 EEVLVTV--RNKSNPLFQSP----YYKVRVPENI--TLYTPILHTQARSPEGLRLIYNIV 2208
+V + V N + P+F P Y++ +P T+ ++ + + Y+IV
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL--GSFSEATVEVLVEDVN 2266
LF D +TG +T+ D H V+A D FS V + V +
Sbjct: 749 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESV 808
Query: 2267 DNPPTFSQLV 2276
N ++LV
Sbjct: 809 TNATLINELV 818
Score = 111 bits (277), Expect = 2e-23
Identities = 165/720 (22%), Positives = 281/720 (39%), Gaps = 103/720 (14%)
Query: 127 ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA 186
E+ L ++ I D ND PLF ++I E+ + S A D D+G N Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR--MRKISEGNGFGSLAALVV 244
+F + + T G + EL D M+ E GF
Sbjct: 210 LIKSQNIFGLDV---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQ------ 260
Query: 245 HVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDANSS-GAEVESVEVVGGDPGK 298
R AI V VT D+ND T V + N+ G V + D G+
Sbjct: 261 ------RSSTAILQVSVT--DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 299 HFKAIKSYAR------------SNEFSLVSVKD-INWMEYLHGFNLSLQARSGSGPYFYS 345
+ K S++ + L+++K+ ++ E + L L + G P
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM 372
Query: 346 QIRGFHLPPSKLSSLKFEKAVYRVQ----LSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPS 400
+ + S+ V V LSE P +++ ++ VT + V +
Sbjct: 373 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 432
Query: 401 SENVGFKLN---ARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCN 452
+ F+L + L+ +D+ Y + + + P S ++ I + D N
Sbjct: 433 DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 492
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYL 511
++AP+F +S ++ EN PG ++ V+ATD D G N + Y + GP A P FS+D
Sbjct: 493 DNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT 551
Query: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
G+++ K +D E + Y F + A D G P V++F+ + + NDN P+F
Sbjct: 552 GMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKF 609
Query: 572 SIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631
+ ++ P ++ ++ D D N + +E + F ++ +GVI RP I+
Sbjct: 610 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDRE 666
Query: 632 QPTSYSLKITASDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQ 690
+ SY+ + A DG + ++ +T+ V D + PV
Sbjct: 667 KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPV---------------------- 704
Query: 691 NQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKL 750
+ + Y +E VL S T + ++ A D D G N ++
Sbjct: 705 --------------FIVPPYNYSYE-------LVLPSTNPGTVVFQVIAVDNDTGMNAEV 743
Query: 751 VYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNV 810
Y I GN F I+ ETG +T+ D + + V DLG P S + ++ VN+
Sbjct: 744 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNL 802
Score = 65.1 bits (157), Expect = 1e-09
Identities = 51/176 (28%), Positives = 85/176 (48%), Gaps = 32/176 (18%)
Query: 108 NREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
+RE ++SYT ++A + + + +V ++++D ND KP+F P Y + +P +P
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP 723
Query: 167 ---ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ +V A D D G NAE Y+ NTR ++FAI +G +T+ K +VT G H +
Sbjct: 724 GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLHRVL 782
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL 276
V A D L +P ++ SVV+ N+ T AT++
Sbjct: 783 VKAND------------------------LGQPDSLFSVVIVNLFVNESVTNATLI 814
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 248 bits (633), Expect = 9e-65
Identities = 199/664 (29%), Positives = 300/664 (45%), Gaps = 34/664 (5%)
Query: 2763 YQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAI 2822
Y+++V + ++ LV + + D+NDN P+F A + EN + + A+
Sbjct: 140 YEVEV---AILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV 196
Query: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESG----WITTLQELDCETCQTYHFHVVAY 2878
D D G +G +Y L N+ L I++ G + +ELD E TY V
Sbjct: 197 DPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVE 254
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
D G Q SS A++QVS+TD NDN P F E S+ EN+ G V L DADI E
Sbjct: 255 DGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGEN 313
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-ASVTV 2997
+ + + + I+ ++ LDRE T + L V ASDG A V
Sbjct: 314 AKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMV 373
Query: 2998 EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI------LKVSATDLDTDTNAQITYSLH 3051
+ V DVNDN P V++ V I ++ TD D D N ++T
Sbjct: 374 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD 433
Query: 3052 GPGAHE--FKLDPHTGE---LTTLTALDRERKDVFNLVAKATDGGGRSCQ--ADITLHVE 3104
HE F+L P L LD E + + A D G A + + V+
Sbjct: 434 ----HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Query: 3105 DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDA 3164
D NDNAP F S V++ +N + + V A D D G NA++ Y L A FS+D
Sbjct: 490 DENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR 549
Query: 3165 TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS 3224
TG++ + K L + T+ A D G P PL++ TV VS++ D PVF + E+
Sbjct: 550 RTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 608
Query: 3225 VQVPEDAPPGTEVLQLATLTRPG-AEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFET 3283
VPE+ P V L T+T P + + + +E F +D++TG++ N S D E
Sbjct: 609 FYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 667
Query: 3284 SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR---VLENALVGDVI 3340
Y ++ S S V +N+ DVN+++P F PY+ VL + G V+
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 727
Query: 3341 LTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
V A D D +N+++ YS++GGN F I + G + + + D + + ++A D
Sbjct: 728 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 787
Query: 3401 SGQP 3404
GQP
Sbjct: 788 LGQP 791
Score = 247 bits (630), Expect = 2e-64
Identities = 199/637 (31%), Positives = 303/637 (47%), Gaps = 43/637 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVY-VIADGNEEGCFDIELETG----LLTVA 775
+I + E+ IN+ AA DPD G NG Y +I N G IE G L V
Sbjct: 177 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQ 236
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ V V D G PQ+SS +L V+V D NDN P F +++I E+ V
Sbjct: 237 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 296
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD +N ++ ++ + F L+ TG + + LDRE P +
Sbjct: 297 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 356
Query: 891 LKVEARD---QPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPG 941
L V A D P++ L +VT DVNDN P + + + + E++P
Sbjct: 357 LLVLASDGGLMPARAMVLVNVT-------DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV-DLMTGALILERE--LDFERRAGYNLS 998
T + + +D D G R FR+ + + +LE LD+E Y +
Sbjct: 410 TKIALITVTDKDADHNG--RVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
L A+D G+P ++ + + V D N+N P SFV + NSP G Q++ V+A D
Sbjct: 468 LLAADAGKPPLNQS-AMLFIKVKDENDNA-PVFTQSFVTVSIPENNSP-GIQLMKVSATD 524
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSG + E+ Y L FS+++ TGM+ + LDRE Y T+LA D G PL+
Sbjct: 525 ADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT 583
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
S V++ + D NDN P + + + E+ P +V + DPD +T +I
Sbjct: 584 SNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILD 643
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
N F I TG++ DRE ++ + V D G S S+++V + ++DVNDN
Sbjct: 644 EN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDN 701
Query: 1239 PPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLV 1296
P+F +N L +PG V++++A D D G+N V YSI + + F+ID
Sbjct: 702 KPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQE 761
Query: 1297 TG---VVSSSSTFTAGEYNILTIKATDSGQPPLSASV 1330
TG ++ G + +L +KA D GQP SV
Sbjct: 762 TGNITLMEKCDVTDLGLHRVL-VKANDLGQPDSLFSV 797
Score = 246 bits (629), Expect = 3e-64
Identities = 207/705 (29%), Positives = 326/705 (46%), Gaps = 38/705 (5%)
Query: 2253 FSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
F + L+ED+NDN P F V SI E + A D D G N +Y+++
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 2313 ED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVN 2368
+ G DV + + ++ +ELD E + + +KV+ D G P + ++ V+
Sbjct: 212 KSQNIFGLDVIETPE-GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 2369 VSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDR 2425
V+D NDN P F++ + E ++ E A G V ++ A D D + +++ + ++S R
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQH 2484
F +N+++G+I++ + ++ L V ASD G+ A V +N T+ N P
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390
Query: 2485 LY------EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNG-QI 2537
L+EN + TK+ + DKD+ G + +++ + N +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 2538 ATLQKLDRENSTERVIAIKVMARDGG----GRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
LD E++ E AIK++A D G + A +K+ DENDN P F S TVS
Sbjct: 451 ENAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 506
Query: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE 2653
I N S +++V A DAD G NA++ Y + P+ ++ TG++ V L +
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRTGMLTVVKKLDREK 564
Query: 2654 NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV 2713
F I A+D G P S V V + ++ + + P F+ Y F PE+LP +G++
Sbjct: 565 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624
Query: 2714 KAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
V D S V + + N D F++D TGVI+ D E + Y V A
Sbjct: 625 -TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 681
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
S V I V DVNDN+PVF P Y+ VL P GT V QV A+D DTG +
Sbjct: 682 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMN 740
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
+V Y + G N +LFAID E+G IT +++ D + V A D GQ L S
Sbjct: 741 AEVRYSI---VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSV 797
Query: 2890 ALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
+V + + + NA +E R S+ P +A + + +D
Sbjct: 798 VIVNLFVNESVTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 238 bits (607), Expect = 1e-61
Identities = 187/702 (26%), Positives = 322/702 (45%), Gaps = 32/702 (4%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH 869
++D NDNAP FP ++I E++ + + D D NG Y L+ F L
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 870 PL-------TGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNS 922
+ +L+V LDRE + Y++KV+ D Q S L +++ D NDN
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNH 278
Query: 923 PQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY----VLMDGAHGTFRVDLMT 978
P + +PE+ P GT +T L A+D D+G ++ + ++ + A F ++ T
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
G + ++ LD E + L + ASDGG AR V V V DVN+N+ V+
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNP 395
Query: 1039 GQ----VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
+ EN P T++ ++ D D+ +G + F + + +++ A
Sbjct: 396 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455
Query: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
LD E Y + +LA D G PL+ ++I+V D NDN P +Q+ SI E+ G
Sbjct: 456 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 515
Query: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
++++ A D DS ++ + + + F + TG+L+ ++LDRE +D+++ +
Sbjct: 516 QLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
DNG P L S V V I+D NDN P+F+H + +PE L G V + +D D G
Sbjct: 575 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP--RHGTVGLITVTDPDYG 632
Query: 1275 LNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPLSASVRL 1332
N VT SI D +++ F+ID TGV+ + +F + T +KA D G+ S+S ++
Sbjct: 633 DNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 1333 HIEWIPWPRPSSIPLAFDETY-YSFTVMETDPVNHMVGVISVEGRPGL---FWFNISGGD 1388
I + + + Y Y + T+P + VI+V+ G+ ++I GG+
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 1389 KDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSR--TIATQVHIFMIANINHHRP 1446
F I++ TG+I + D + + V+ D + ++ + V + + N +
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Query: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGS 1488
+ + P E+ V + D K L+ + G+
Sbjct: 812 TLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853
Score = 223 bits (568), Expect = 3e-57
Identities = 193/633 (30%), Positives = 293/633 (46%), Gaps = 58/633 (9%)
Query: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI-------YSL 2726
LV +R + + P F + S PE+ S+ + AV DP + Y L
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV---DPDVGINGVQNYEL 210
Query: 2727 VRGT---------TPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
++ TPE +K + V+K +D E Y + V
Sbjct: 211 IKSQNIFGLDVIETPEGDK---------MPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 261
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
S + + V D NDN PVF+ + + EN PVGTSV Q+ A D D G + ++ + S
Sbjct: 262 SSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 321
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSIT 2897
+ LF +++ +G IT + LD E + V+A D G + ++A+V V++T
Sbjct: 322 NLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVT 378
Query: 2898 DENDNAP----RFASEEYRGSVV--ENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
D NDN P R+ +VV EN +A + D D ++ N +VTC+ P
Sbjct: 379 DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD-ADHNGRVTCFTDHEIP 437
Query: 2952 LGQFGISQV-GDEWRISSRKTLDREHTAKYLLRVTASD-GK--FQASVTVEIFVLDVNDN 3007
F + V +++ + + LD E T +Y +++ A+D GK S + I V D NDN
Sbjct: 438 ---FRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 494
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
+P +Q T + E+ PG ++KVSATD D+ NA+I Y L EF LD TG L
Sbjct: 495 APVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 554
Query: 3068 TTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDN 3125
T + LDRE++D + A D G +++T+ V D NDN+P F + V +N
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 614
Query: 3126 TTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL 3185
V ++ DPD G N+ V S+ D + F+ID+ TGVIR Q
Sbjct: 615 LPRHGTVGLITVTDPDYGDNSAVTLSILDEND-DFTIDSQTGVIRPNISFDREKQESYTF 673
Query: 3186 TVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL----NTEHSVQVPEDAPPGTEVLQLA 3241
V+A D G + S+ VT++VV + D PVF+ N + + +P PGT V Q+
Sbjct: 674 YVKAED-GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVI 731
Query: 3242 TL---TRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ T AE Y +V GN + F +D TG
Sbjct: 732 AVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETG 763
Score = 218 bits (556), Expect = 8e-56
Identities = 209/756 (27%), Positives = 346/756 (45%), Gaps = 71/756 (9%)
Query: 872 TGELVVTG-HLDRES-------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
TGE+ TG +DRE + +VE P ++F + + +ED+NDN+P
Sbjct: 113 TGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAP 169
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM------ 977
+ +PE+ + T A DPD+G G Y L+ + F +D++
Sbjct: 170 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-SQNIFGLDVIETPEGD 228
Query: 978 -TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFV 1036
LI+++ELD E + Y + + DGG P R + ++V V D N+N P F
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDN--HPVFKETE 285
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYF---LRAGTGLAAFSINQDTGMIQTLA 1093
+ + EN+P GT V + A D D G + ++ + L + F +N TG+I
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMS-QAVFYP-----SIQ 1147
PLDRE + L VLA D G +P ++ V + VTD NDN P + + + P +
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG---LLSTAQQLDREN 1204
E+ P+ T + + D D+ G++T ++ F + PV LL A LD E+
Sbjct: 404 ENIPLNTKIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLENAAYLDYES 460
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY 1264
E+ +++ D G+P L ++ + + + D NDN P+F+ V +PE SP +
Sbjct: 461 TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLM 518
Query: 1265 RLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG---VVSSSSTFTAGEYNILTIKATDS 1321
++ A+D D G N + Y + FS+D TG VV +Y + TI A D+
Sbjct: 519 KVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKY-LFTILAKDN 577
Query: 1322 GQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRP 1377
G PPL+++V + + I S + F Y F V E P + VG+I+V G
Sbjct: 578 GVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 634
Query: 1378 GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVH 1434
+I D++ DF I+ TG I D ++ +Y V+ DG SR+ + +V
Sbjct: 635 SAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 692
Query: 1435 IFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGS 1488
I + ++N ++P F+ YE+ +P T PG + +V A+D D G + + Y+I G
Sbjct: 693 I-NVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 750
Query: 1489 QDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVED 1547
+ LF +D +G + + K D+ + H + V D P + V V + V +
Sbjct: 751 ---NTRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 806
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+ +L S+ + P TE+ V + +D
Sbjct: 807 SVTNATLINEL-VRKSIEAPVTPNTEIADVSSPTSD 841
Score = 209 bits (533), Expect = 4e-53
Identities = 197/716 (27%), Positives = 316/716 (44%), Gaps = 56/716 (7%)
Query: 1997 LNDTLSYFLLNGTD---MFHMVQSAGVLQTRGVAFDREQ------QDTHELAVEVRDNRT 2047
L T+ + L+ T + + + G + T G DRE+ +D H EV
Sbjct: 89 LTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEH-CFYEVEVAIL 147
Query: 2048 PQRVAQGL-VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVT 2106
P + + + +R IED+NDN P F I + + +A D D+G NG
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 2107 YEFAEDYTYFRID-------PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE-- 2157
YE + F +D + + ++K D + + Y +KV DGG P S
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAIL 267
Query: 2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPI--LH-TQARSPEGLRLIY---NIVEEE 2211
+V VT N ++P+F+ +V +PEN + T + LH T A E ++ + N+V
Sbjct: 268 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI 327
Query: 2212 PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPT 2271
LF + TG++T+ PLD E H V A+D L + A V V V DVNDN P+
Sbjct: 328 ARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVLVNVTDVNDNVPS 386
Query: 2272 F------SQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
+ + T +SE +P T + + +D+D+ N V+ D + +
Sbjct: 387 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVF 444
Query: 2326 GSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYE 2385
+ + LDYE+ + + +K+ A D G PPL ++ + V D NDN P F Q
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 2386 ANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKH 2445
++ E + G ++KV A D DS + + YL L + F ++ +G++++ +
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYL-LGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 2446 LDSSYNLRVGASD-GV--FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID 2502
+ Y + A D GV + V V+++ + N SP F + Y+ + EN V
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623
Query: 2503 LLAIDKDSGPYGTIDYTIINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
+ D D G + +I+++ ++ F+I + G I DRE +K A D
Sbjct: 624 ITVTDPDYGDNSAVTLSILDE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED 679
Query: 2562 GG--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSP---VIQVLAYDADEGQ 2616
GG R + V I + D NDN P F Y S + + +P V QV+A D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 739
Query: 2617 NADVTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
NA+V YS+ N DL E +T + K + +GL +KA D G P
Sbjct: 740 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHR----VLVKANDLGQP 791
Score = 207 bits (526), Expect = 2e-52
Identities = 187/656 (28%), Positives = 295/656 (44%), Gaps = 37/656 (5%)
Query: 2458 DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTID 2517
D +FR V + + N +P F + + EN+ + +K A+D D G G +
Sbjct: 149 DEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 2518 YTIINKLASEKFSI--NPNG----QIATLQKLDRENSTERVIAIKVMARDGG--GRVAFC 2569
Y +I + P G Q+ ++LDRE V+ +KV DGG R +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKV--EDGGFPQRSSTA 265
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN--PE 2627
+++ +TD NDN P FK +E VSI N + V Q+ A DAD G+NA + +S +
Sbjct: 266 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325
Query: 2628 DLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKV- 2686
++ + + +N TG++ +K+ L E + A DGG ++V V + V V
Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 385
Query: 2687 --SLPKFSEPLY-TFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLD 2743
+ P+ T E++P ++I ++ V +D V T + +
Sbjct: 386 SIDIRYIVNPVNDTVVLSENIPLNTKIALI-TVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 2744 PDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
+ +++ +D+ESTK Y I ++A + + I+V D NDN PVF
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 2804 AVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQEL 2863
+ EN G +++V+A D D+G + +++Y L D F++D +G +T +++L
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE----FSLDRRTGMLTVVKKL 560
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E Y F ++A D+G L+S V VSI D+NDN+P F EY+ V EN
Sbjct: 561 DREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 619
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D + + + E D F I SQ G I + DRE Y
Sbjct: 620 TVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTG---VIRPNISFDREKQESYTF 673
Query: 2983 RVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSAT 3036
V A DG +S V I V+DVNDN P Y V PG + +V A
Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733
Query: 3037 DLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
D DT NA++ YS+ G + F +D TG +T + D + ++ KA D G
Sbjct: 734 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLG 789
Score = 201 bits (512), Expect = 1e-50
Identities = 181/660 (27%), Positives = 292/660 (44%), Gaps = 38/660 (5%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
++ I D NDNAP F + S+ ENS +D D+ Q I +
Sbjct: 157 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 216
Query: 2952 LGQFGI-SQVGDEW-RISSRKTLDREHTAKYLLRVTASDGKF---QASVTVEIFVLDVND 3006
G I + GD+ ++ +K LDRE Y+++V DG F ++ +++ V D ND
Sbjct: 217 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 276
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS----LHGPGAHEFKLDP 3062
N P + + E+ G + ++ ATD D NA+I +S + F L+
Sbjct: 277 NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNA 336
Query: 3063 HTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAP----RFF--PS 3116
TG +T LDRE L+ A+DGG +A + ++V DVNDN P R+ P
Sbjct: 337 TTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV----YSLPDSAEGHFSIDATTGVIRLE 3172
+ V + +N + T +A++ D D N +V + +P FS LE
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS-----NQFLLE 451
Query: 3173 KPLQVRPQAPLELTVR--ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ ++ E ++ A+D G P PL+ + + V D PVF + +V +PE+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 3231 APPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTGILYVNASLDFETSPKYFL 3289
PG ++++++ + G + F LD RTG+L V LD E KY
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLF 570
Query: 3290 SIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED 3349
+I L+ TV V+I D N++ P F + Y V EN + ++ TD D
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHED 3409
NS +T S++ N FTI + G ++ + DRE+ SY+ ++A D G+
Sbjct: 631 YGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 3410 TDIAIQVADVNDNPPRF----FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR 3465
+ I V DVNDN P F + +Y + +P G+ V Q+I D D+ N +
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA-EVRYS 746
Query: 3466 ITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
I GN F + + G + E +++ ++A+D G P L S+ V + V E
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 806
Score = 199 bits (505), Expect = 7e-50
Identities = 190/663 (28%), Positives = 294/663 (44%), Gaps = 44/663 (6%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L + ++ D+N+N P F + V + ENS ++ + AA D D G++G Y L
Sbjct: 154 LVKIRFLIEDINDNA--PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 1073 AGT---GLAAFSINQDTGMIQTLAP--LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
GL + M Q + LDRE Y + V D G SS + + V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF---NITSGNYMGF 1184
TD NDN P + SI E+APVGTSV QL A D D K+ F N+ S
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H L V D G + + + V+V + DVNDN P
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDI 389
Query: 1245 KLF------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT----YSIEDSDEEAFSID 1294
+ V L E + P++ + + +D D NGRVT + I FS
Sbjct: 390 RYIVNPVNDTVVLSENI-PLNT-KIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ 447
Query: 1295 LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
+ + + EY I + A D+G+PPL+ S L I+ + P+ F +++
Sbjct: 448 FLLENAAYLDYESTKEYAIKLL-AADAGKPPLNQSAMLFIK--VKDENDNAPV-FTQSFV 503
Query: 1355 SFTVMETDPVNHMVGVISV---EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
+ ++ E + + +S + P + G D +F +++ TG + + + LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 1412 RRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
+ Y T+ D G + + V +F+ I + N + P F Y+ VP++ +
Sbjct: 564 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 623
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
+ D D G + T+ + F +D +GV+ D S +T V D
Sbjct: 624 ITVTDPDYGDNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQES-YTFYVKAED 679
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFT----QLHYEASVPDTIAPGTELLQVRAMDADRG 1585
+ + VTI+V D N + P F YE +P T PGT + QV A+D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTG 738
Query: 1586 VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+NAEV YS++ GN+ F I+ G ITL +K D + H + VKA D G P L +
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD--SLFS 796
Query: 1646 VII 1648
V+I
Sbjct: 797 VVI 799
Score = 195 bits (496), Expect = 7e-49
Identities = 190/760 (25%), Positives = 331/760 (43%), Gaps = 86/760 (11%)
Query: 1193 LLSTAQQLDREN------KDEHI---LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFS 1243
+ +T ++DRE +DEH +EV +L + + ++ I D+NDN P+F
Sbjct: 116 IFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAPLFP 172
Query: 1244 HKLFNVRLPERLSPVSPGPVYRLVAS-DLDEGLNGRVTYSIEDSDEEAFSIDLVTG---- 1298
+ N+ +PE + S Y L A+ D D G+NG Y + S + F +D++
Sbjct: 173 ATVINISIPENSAINSK---YTLPAAVDPDVGINGVQNYELIKS-QNIFGLDVIETPEGD 228
Query: 1299 -----VVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+V + ++ +K D G P S++ L + + F ET
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETE 285
Query: 1354 YSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMD---FDIEKTTGSIVIAR 1406
++ E PV V + G F+ S ++ F + TTG I I
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 1407 PLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV---- 1462
PLD N+ L V +DG A + + + ++N + P ++ RY V DTV
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPS-IDIRYIVNPVNDTVVLSE 404
Query: 1463 -----PGVELLRVQAIDQD-KGKSLIYTIHGSQDPGSASLFQLDP---SSGVLVTVGKLD 1513
+ L+ V D D G+ +T H F+L P + +L LD
Sbjct: 405 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-------FRLRPVFSNQFLLENAAYLD 457
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
S ++ + ++ D P + I V+D N + P FTQ S+P+ +PG +
Sbjct: 458 YES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 516
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
L++V A DAD G NAE++Y LL ++ F+++ G++T+ +KLD+ + T+ A+
Sbjct: 517 LMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
D G P TV + + + ++P+F+ +EY +PE++P + L++ P S
Sbjct: 576 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 635
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSY--QLKIRGSNMAGAFTDVMVVV 1746
VT + + N D F+++S +G+I D EK SY +K + V +
Sbjct: 636 AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 693
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN---PFVIHASDSDKEANSLLVYK 1803
+++D NDN P+F+ + Y +++ N F + A D+D N+ + Y
Sbjct: 694 NVVDVNDNKPVFIVPPYNYS-------YELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 746
Query: 1804 ILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP-VLFAPRPAQVIIHV 1862
I+ F ID G +T++ + D + + V +D G P LF+ V+I
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFS-----VVIVN 801
Query: 1863 RDVNDSPPRFS--EQIYEVAIVGPIHPGMELLMVRASDED 1900
VN+S + ++ +I P+ P E+ V + D
Sbjct: 802 LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 180 bits (457), Expect = 2e-44
Identities = 154/580 (26%), Positives = 252/580 (43%), Gaps = 30/580 (5%)
Query: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
+ R+ Y + V + V + + D+NDN+P + + E+
Sbjct: 132 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 191
Query: 3032 KVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVA 3085
+A D D N Y L G E +L LDRE KD + +
Sbjct: 192 LPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKV 251
Query: 3086 KATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
K DGG RS A + + V D NDN P F + V++ +N V T V + A D D G
Sbjct: 252 KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 311
Query: 3144 ANAQVVYS----LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
NA++ +S + + A F ++ATTG+I +++PL +L V ASD G +
Sbjct: 312 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MP 368
Query: 3200 TLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGY 3253
V V+V + D +P + +V + E+ P T++ L T+T A+ G
Sbjct: 369 ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIA-LITVTDKDADHNGR 427
Query: 3254 RVVSGNEQGRFRLD---ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVN 3310
+ + FRL + +L A LD+E++ +Y + + + L+ + +
Sbjct: 428 VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 487
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D N++ P F Q + + EN G ++ VSATD D N++I Y L+G + F+
Sbjct: 488 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFS 546
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ + G L V K LDRE+ Y + A D+G PPL + + + + D NDN P F
Sbjct: 547 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 606
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE-GL 3489
Y V EN P V + ++DPD +N + ++ + F + ++
Sbjct: 607 YKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 3490 SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
R QE Y ++A D G SS V ++V + + P
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 703
Score = 171 bits (434), Expect = 1e-41
Identities = 155/531 (29%), Positives = 244/531 (45%), Gaps = 37/531 (6%)
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHF 3160
+ED+NDNAP F + +++ +N+ + + + A DPD G N Y L S G
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 3161 SIDATTG----VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP 3216
I+ G + ++K L + + V+ D G P ST + VSV D P
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHP 279
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYR-----VVSGNEQGRFRLDARTG 3271
VF TE V +PE+AP GT V QL E +VS + F L+A TG
Sbjct: 280 VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG 339
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP----QFPQDPYS 3327
++ + LD E +P + L + S + V+VN+TDVN++ P ++ +P +
Sbjct: 340 LITIKEPLDREETPNHKLLVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVN 397
Query: 3328 TRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
V+ EN + I ++ TD+D N +T + + L+ A LD
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 457
Query: 3386 REQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKV 3445
E Y++KL A D+G+PPL++ + I+V D NDN P F Q + ++ EN+ G ++
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 517
Query: 3446 LQLILSDPDSPENGPPYSFRITKGNNG----SAFRVTPDGWLVTAEGLSRRAQEWYQLQI 3501
+++ +D DS GP G + S R T G L + L R ++ Y I
Sbjct: 518 MKVSATDADS---GPNAEINYLLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTI 572
Query: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQ 3561
A D+G+PPL+S +V V + +Q+ +P E V E+ + G VG I TD D
Sbjct: 573 LAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 632
Query: 3562 D--TLTYSLAEEETLGRHFSVGAPDGKI---IAAQGLPRGHYSFNVTVSDG 3607
D +T S+ +E F++ + G I I+ + Y+F V DG
Sbjct: 633 DNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 680
Score = 169 bits (427), Expect = 7e-41
Identities = 181/720 (25%), Positives = 298/720 (41%), Gaps = 98/720 (13%)
Query: 425 DRAHYQLHIRTSPGQASTVVVID--IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
+ Y++ + P + +V I I D N++APLF + + ++ EN + A
Sbjct: 136 EHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 195
Query: 483 TDRDHGENGYVTYSIAGPKALPFSIDPY-------LGIISTSKPMDYELMKRIYTFRVRA 535
D D G NG Y + + + F +D + + K +D E K Y +V+
Sbjct: 196 VDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDRE-EKDTYVMKVKV 253
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + + NDN P+F+E SI ++ PVG S+ + A D D +
Sbjct: 254 EDGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 596 NLKYE-----IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNY 648
N K +VS F LN +G+I++K P L + ++ L + ASDG
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP---LDREETPNHKLLVLASDGGLMPA 369
Query: 649 ASPTTLNITVVKD--PHFEV-----PVT------------------------CDKTGVLT 677
+ +N+T V D P ++ PV D G +T
Sbjct: 370 RAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT 429
Query: 678 QFTKTILHF---------IGLQNQESSDEEFTSLSTYQI--------------------- 707
FT + F L+N D E T ++
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 489
Query: 708 --NHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEGCFD 764
N P F F ++ + E+ L +++ATD D+G N ++ Y++ D E F
Sbjct: 490 DENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FS 546
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
++ TG+LTV LD E + Y+ + D G P +S + V++ D NDN+P F
Sbjct: 547 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 606
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Y+ + E+ T+ +T D D DN V ++L + F++ TG + DRE
Sbjct: 607 YKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE 666
Query: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP---PG 941
+ Y V+A D S + I + DVNDN P I LP PG
Sbjct: 667 KQESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLW 1000
TV+ + A D D G EVRY ++ G F +D TG + L + D + + +
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVK 784
Query: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
A+D G+P +L V ++ L VNE++ + + + ++ T++ V++ D
Sbjct: 785 ANDLGQP---DSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 152 bits (383), Expect = 9e-36
Identities = 139/542 (25%), Positives = 245/542 (45%), Gaps = 40/542 (7%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + ++ + + T ++ V + D ND P+F V+I E+ P+ +
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G+NA+ +++F N +F ++ T+G++T+ L+ H+L
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP-------DSNDGTTYA 273
VLA S+G + A ++V+V P+I + P N
Sbjct: 359 VLA-------SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 411
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
L+ A+ D F+ + SN+F L + +++ L
Sbjct: 412 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVF--SNQFLLENAAYLDYESTKEYAIKLL 469
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA--FP 391
A +G P S + + ++ F ++ V + E + PG +++ V T A P
Sbjct: 470 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 392 N--LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVV 444
N + Y+L P + F L+ RTG++T K +D Y I P ++ V
Sbjct: 530 NAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 588
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP 504
+ I+D N+++P+F + Y + EN+P +V +T TD D+G+N VT SI
Sbjct: 589 FVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND-D 647
Query: 505 FSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMF 564
F+ID G+I + D E + YTF V+A D G R + + + ++NDN+P+F
Sbjct: 648 FTIDSQTGVIRPNISFDRE-KQESYTFYVKAED-GGRVSRSSSAKVTINVVDVNDNKPVF 705
Query: 565 EEVNCTGSIRQDWP---VGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
S P G + + A+D D N ++Y IV GN + F ++ +G I
Sbjct: 706 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI 765
Query: 620 SL 621
+L
Sbjct: 766 TL 767
Score = 148 bits (374), Expect = 1e-34
Identities = 164/670 (24%), Positives = 279/670 (41%), Gaps = 67/670 (10%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL-REGNKDGVFSMNSYS 1709
+AP+F + + IPE+ + S L +A+ P YEL + N G+ + +
Sbjct: 167 NAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPE 226
Query: 1710 G----LISTQKKLDHEKISSYQLKIRGSNMAGAF----TDVMVVVDIIDENDNAPMFLKS 1761
G + QK+LD E+ +Y +K++ + G F + ++ V + D NDN P+F ++
Sbjct: 227 GDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNHPVFKET 284
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYK---ILEPEALKFFKIDPS 1818
I E AP+ + + +HA+D+D N+ + + ++ A + F ++ +
Sbjct: 285 EIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 337
Query: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
G +TI +D E P+ + V D G P A V+++V DVND+ P +
Sbjct: 338 TGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY-- 391
Query: 1879 VAIVGPIHPGM----------ELLMVRASDEDSEVNYSIKTGNADEA-VTIHPVTGSISV 1927
IV P++ + ++ ++ +D+D++ N + E + PV + +
Sbjct: 392 --IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 1928 L-NPAFLGLS-------RKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
L N A+L + L A +A++ I + D + F Q ++ E
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 509
Query: 1980 NLQDRKALVILGAQGNHLNDTLSYFLLNGTDM---FHMVQSAGVLQTRGVAFDREQQDTH 2036
N L+ + A L G D F + + G+L T DRE++D +
Sbjct: 510 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML-TVVKKLDREKEDKY 568
Query: 2037 ELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ +DN P + V VSI D NDN P F H Y + + + ++ TD
Sbjct: 569 LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 628
Query: 2097 EDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSE 2156
D G N AVT ++ F ID G I FD + Y V A DGG S S
Sbjct: 629 PDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 2157 EEVLVTV--RNKSNPLFQSP----YYKVRVPENI--TLYTPILHTQARSPEGLRLIYNIV 2208
+V + V N + P+F P Y++ +P T+ ++ + + Y+IV
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL--GSFSEATVEVLVEDVN 2266
LF D +TG +T+ D H V+A D FS V + V +
Sbjct: 749 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESV 808
Query: 2267 DNPPTFSQLV 2276
N ++LV
Sbjct: 809 TNATLINELV 818
Score = 111 bits (277), Expect = 2e-23
Identities = 165/720 (22%), Positives = 281/720 (39%), Gaps = 103/720 (14%)
Query: 127 ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA 186
E+ L ++ I D ND PLF ++I E+ + S A D D+G N Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR--MRKISEGNGFGSLAALVV 244
+F + + T G + EL D M+ E GF
Sbjct: 210 LIKSQNIFGLDV---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQ------ 260
Query: 245 HVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDANSS-GAEVESVEVVGGDPGK 298
R AI V VT D+ND T V + N+ G V + D G+
Sbjct: 261 ------RSSTAILQVSVT--DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 299 HFKAIKSYAR------------SNEFSLVSVKD-INWMEYLHGFNLSLQARSGSGPYFYS 345
+ K S++ + L+++K+ ++ E + L L + G P
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM 372
Query: 346 QIRGFHLPPSKLSSLKFEKAVYRVQ----LSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPS 400
+ + S+ V V LSE P +++ ++ VT + V +
Sbjct: 373 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 432
Query: 401 SENVGFKLN---ARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCN 452
+ F+L + L+ +D+ Y + + + P S ++ I + D N
Sbjct: 433 DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 492
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYL 511
++AP+F +S ++ EN PG ++ V+ATD D G N + Y + GP A P FS+D
Sbjct: 493 DNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT 551
Query: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
G+++ K +D E + Y F + A D G P V++F+ + + NDN P+F
Sbjct: 552 GMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKF 609
Query: 572 SIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631
+ ++ P ++ ++ D D N + +E + F ++ +GVI RP I+
Sbjct: 610 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDRE 666
Query: 632 QPTSYSLKITASDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQ 690
+ SY+ + A DG + ++ +T+ V D + PV
Sbjct: 667 KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPV---------------------- 704
Query: 691 NQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKL 750
+ + Y +E VL S T + ++ A D D G N ++
Sbjct: 705 --------------FIVPPYNYSYE-------LVLPSTNPGTVVFQVIAVDNDTGMNAEV 743
Query: 751 VYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNV 810
Y I GN F I+ ETG +T+ D + + V DLG P S + ++ VN+
Sbjct: 744 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNL 802
Score = 65.1 bits (157), Expect = 1e-09
Identities = 51/176 (28%), Positives = 85/176 (48%), Gaps = 32/176 (18%)
Query: 108 NREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
+RE ++SYT ++A + + + +V ++++D ND KP+F P Y + +P +P
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP 723
Query: 167 ---ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ +V A D D G NAE Y+ NTR ++FAI +G +T+ K +VT G H +
Sbjct: 724 GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLHRVL 782
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL 276
V A D L +P ++ SVV+ N+ T AT++
Sbjct: 783 VKAND------------------------LGQPDSLFSVVIVNLFVNESVTNATLI 814
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 248 bits (633), Expect = 9e-65
Identities = 199/664 (29%), Positives = 300/664 (45%), Gaps = 34/664 (5%)
Query: 2763 YQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAI 2822
Y+++V + ++ LV + + D+NDN P+F A + EN + + A+
Sbjct: 129 YEVEV---AILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV 185
Query: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESG----WITTLQELDCETCQTYHFHVVAY 2878
D D G +G +Y L N+ L I++ G + +ELD E TY V
Sbjct: 186 DPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVE 243
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
D G Q SS A++QVS+TD NDN P F E S+ EN+ G V L DADI E
Sbjct: 244 DGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGEN 302
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-ASVTV 2997
+ + + + I+ ++ LDRE T + L V ASDG A V
Sbjct: 303 AKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMV 362
Query: 2998 EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI------LKVSATDLDTDTNAQITYSLH 3051
+ V DVNDN P V++ V I ++ TD D D N ++T
Sbjct: 363 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD 422
Query: 3052 GPGAHE--FKLDPHTGE---LTTLTALDRERKDVFNLVAKATDGGGRSCQ--ADITLHVE 3104
HE F+L P L LD E + + A D G A + + V+
Sbjct: 423 ----HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 478
Query: 3105 DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDA 3164
D NDNAP F S V++ +N + + V A D D G NA++ Y L A FS+D
Sbjct: 479 DENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR 538
Query: 3165 TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS 3224
TG++ + K L + T+ A D G P PL++ TV VS++ D PVF + E+
Sbjct: 539 RTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 597
Query: 3225 VQVPEDAPPGTEVLQLATLTRPG-AEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFET 3283
VPE+ P V L T+T P + + + +E F +D++TG++ N S D E
Sbjct: 598 FYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 656
Query: 3284 SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR---VLENALVGDVI 3340
Y ++ S S V +N+ DVN+++P F PY+ VL + G V+
Sbjct: 657 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 716
Query: 3341 LTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
V A D D +N+++ YS++GGN F I + G + + + D + + ++A D
Sbjct: 717 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 776
Query: 3401 SGQP 3404
GQP
Sbjct: 777 LGQP 780
Score = 247 bits (630), Expect = 2e-64
Identities = 199/637 (31%), Positives = 303/637 (47%), Gaps = 43/637 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVY-VIADGNEEGCFDIELETG----LLTVA 775
+I + E+ IN+ AA DPD G NG Y +I N G IE G L V
Sbjct: 166 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQ 225
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ V V D G PQ+SS +L V+V D NDN P F +++I E+ V
Sbjct: 226 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 285
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD +N ++ ++ + F L+ TG + + LDRE P +
Sbjct: 286 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 345
Query: 891 LKVEARD---QPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPG 941
L V A D P++ L +VT DVNDN P + + + + E++P
Sbjct: 346 LLVLASDGGLMPARAMVLVNVT-------DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 398
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV-DLMTGALILERE--LDFERRAGYNLS 998
T + + +D D G R FR+ + + +LE LD+E Y +
Sbjct: 399 TKIALITVTDKDADHNG--RVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 456
Query: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
L A+D G+P ++ + + V D N+N P SFV + NSP G Q++ V+A D
Sbjct: 457 LLAADAGKPPLNQS-AMLFIKVKDENDNA-PVFTQSFVTVSIPENNSP-GIQLMKVSATD 513
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSG + E+ Y L FS+++ TGM+ + LDRE Y T+LA D G PL+
Sbjct: 514 ADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT 572
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
S V++ + D NDN P + + + E+ P +V + DPD +T +I
Sbjct: 573 SNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILD 632
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
N F I TG++ DRE ++ + V D G S S+++V + ++DVNDN
Sbjct: 633 EN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDN 690
Query: 1239 PPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLV 1296
P+F +N L +PG V++++A D D G+N V YSI + + F+ID
Sbjct: 691 KPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQE 750
Query: 1297 TG---VVSSSSTFTAGEYNILTIKATDSGQPPLSASV 1330
TG ++ G + +L +KA D GQP SV
Sbjct: 751 TGNITLMEKCDVTDLGLHRVL-VKANDLGQPDSLFSV 786
Score = 246 bits (629), Expect = 3e-64
Identities = 207/705 (29%), Positives = 326/705 (46%), Gaps = 38/705 (5%)
Query: 2253 FSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
F + L+ED+NDN P F V SI E + A D D G N +Y+++
Sbjct: 141 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 200
Query: 2313 ED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVN 2368
+ G DV + + ++ +ELD E + + +KV+ D G P + ++ V+
Sbjct: 201 KSQNIFGLDVIETPE-GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 259
Query: 2369 VSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDR 2425
V+D NDN P F++ + E ++ E A G V ++ A D D + +++ + ++S R
Sbjct: 260 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQH 2484
F +N+++G+I++ + ++ L V ASD G+ A V +N T+ N P
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 379
Query: 2485 LY------EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNG-QI 2537
L+EN + TK+ + DKD+ G + +++ + N +
Sbjct: 380 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 439
Query: 2538 ATLQKLDRENSTERVIAIKVMARDGG----GRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
LD E++ E AIK++A D G + A +K+ DENDN P F S TVS
Sbjct: 440 ENAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 495
Query: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE 2653
I N S +++V A DAD G NA++ Y + P+ ++ TG++ V L +
Sbjct: 496 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRTGMLTVVKKLDREK 553
Query: 2654 NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV 2713
F I A+D G P S V V + ++ + + P F+ Y F PE+LP +G++
Sbjct: 554 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 613
Query: 2714 KAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
V D S V + + N D F++D TGVI+ D E + Y V A
Sbjct: 614 -TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 670
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
S V I V DVNDN+PVF P Y+ VL P GT V QV A+D DTG +
Sbjct: 671 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMN 729
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
+V Y + G N +LFAID E+G IT +++ D + V A D GQ L S
Sbjct: 730 AEVRYSI---VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSV 786
Query: 2890 ALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
+V + + + NA +E R S+ P +A + + +D
Sbjct: 787 VIVNLFVNESVTNA-TLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 238 bits (607), Expect = 1e-61
Identities = 187/702 (26%), Positives = 322/702 (45%), Gaps = 32/702 (4%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH 869
++D NDNAP FP ++I E++ + + D D NG Y L+ F L
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 870 PL-------TGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNS 922
+ +L+V LDRE + Y++KV+ D Q S L +++ D NDN
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNH 267
Query: 923 PQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY----VLMDGAHGTFRVDLMT 978
P + +PE+ P GT +T L A+D D+G ++ + ++ + A F ++ T
Sbjct: 268 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 327
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
G + ++ LD E + L + ASDGG AR V V V DVN+N+ V+
Sbjct: 328 GLITIKEPLDREETPNHKLLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNP 384
Query: 1039 GQ----VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
+ EN P T++ ++ D D+ +G + F + + +++ A
Sbjct: 385 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 444
Query: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
LD E Y + +LA D G PL+ ++I+V D NDN P +Q+ SI E+ G
Sbjct: 445 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 504
Query: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
++++ A D DS ++ + + + F + TG+L+ ++LDRE +D+++ +
Sbjct: 505 QLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 563
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
DNG P L S V V I+D NDN P+F+H + +PE L G V + +D D G
Sbjct: 564 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP--RHGTVGLITVTDPDYG 621
Query: 1275 LNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPLSASVRL 1332
N VT SI D +++ F+ID TGV+ + +F + T +KA D G+ S+S ++
Sbjct: 622 DNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 680
Query: 1333 HIEWIPWPRPSSIPLAFDETY-YSFTVMETDPVNHMVGVISVEGRPGL---FWFNISGGD 1388
I + + + Y Y + T+P + VI+V+ G+ ++I GG+
Sbjct: 681 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 740
Query: 1389 KDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSR--TIATQVHIFMIANINHHRP 1446
F I++ TG+I + D + + V+ D + ++ + V + + N +
Sbjct: 741 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 800
Query: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGS 1488
+ + P E+ V + D K L+ + G+
Sbjct: 801 TLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 842
Score = 223 bits (568), Expect = 3e-57
Identities = 193/633 (30%), Positives = 293/633 (46%), Gaps = 58/633 (9%)
Query: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI-------YSL 2726
LV +R + + P F + S PE+ S+ + AV DP + Y L
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV---DPDVGINGVQNYEL 199
Query: 2727 VRGT---------TPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
++ TPE +K + V+K +D E Y + V
Sbjct: 200 IKSQNIFGLDVIETPEGDK---------MPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 250
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
S + + V D NDN PVF+ + + EN PVGTSV Q+ A D D G + ++ + S
Sbjct: 251 SSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 310
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSIT 2897
+ LF +++ +G IT + LD E + V+A D G + ++A+V V++T
Sbjct: 311 NLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVT 367
Query: 2898 DENDNAP----RFASEEYRGSVV--ENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
D NDN P R+ +VV EN +A + D D ++ N +VTC+ P
Sbjct: 368 DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD-ADHNGRVTCFTDHEIP 426
Query: 2952 LGQFGISQV-GDEWRISSRKTLDREHTAKYLLRVTASD-GK--FQASVTVEIFVLDVNDN 3007
F + V +++ + + LD E T +Y +++ A+D GK S + I V D NDN
Sbjct: 427 ---FRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 483
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
+P +Q T + E+ PG ++KVSATD D+ NA+I Y L EF LD TG L
Sbjct: 484 APVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 543
Query: 3068 TTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDN 3125
T + LDRE++D + A D G +++T+ V D NDN+P F + V +N
Sbjct: 544 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 603
Query: 3126 TTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL 3185
V ++ DPD G N+ V S+ D + F+ID+ TGVIR Q
Sbjct: 604 LPRHGTVGLITVTDPDYGDNSAVTLSILDEND-DFTIDSQTGVIRPNISFDREKQESYTF 662
Query: 3186 TVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL----NTEHSVQVPEDAPPGTEVLQLA 3241
V+A D G + S+ VT++VV + D PVF+ N + + +P PGT V Q+
Sbjct: 663 YVKAED-GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVI 720
Query: 3242 TL---TRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ T AE Y +V GN + F +D TG
Sbjct: 721 AVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETG 752
Score = 218 bits (556), Expect = 8e-56
Identities = 209/756 (27%), Positives = 346/756 (45%), Gaps = 71/756 (9%)
Query: 872 TGELVVTG-HLDRES-------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
TGE+ TG +DRE + +VE P ++F + + +ED+NDN+P
Sbjct: 102 TGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAP 158
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM------ 977
+ +PE+ + T A DPD+G G Y L+ + F +D++
Sbjct: 159 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-SQNIFGLDVIETPEGD 217
Query: 978 -TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFV 1036
LI+++ELD E + Y + + DGG P R + ++V V D N+N P F
Sbjct: 218 KMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDN--HPVFKETE 274
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYF---LRAGTGLAAFSINQDTGMIQTLA 1093
+ + EN+P GT V + A D D G + ++ + L + F +N TG+I
Sbjct: 275 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMS-QAVFYP-----SIQ 1147
PLDRE + L VLA D G +P ++ V + VTD NDN P + + + P +
Sbjct: 335 PLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 392
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG---LLSTAQQLDREN 1204
E+ P+ T + + D D+ G++T ++ F + PV LL A LD E+
Sbjct: 393 ENIPLNTKIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLENAAYLDYES 449
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY 1264
E+ +++ D G+P L ++ + + + D NDN P+F+ V +PE SP +
Sbjct: 450 TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLM 507
Query: 1265 RLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG---VVSSSSTFTAGEYNILTIKATDS 1321
++ A+D D G N + Y + FS+D TG VV +Y + TI A D+
Sbjct: 508 KVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKY-LFTILAKDN 566
Query: 1322 GQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRP 1377
G PPL+++V + + I S + F Y F V E P + VG+I+V G
Sbjct: 567 GVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 623
Query: 1378 GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVH 1434
+I D++ DF I+ TG I D ++ +Y V+ DG SR+ + +V
Sbjct: 624 SAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 681
Query: 1435 IFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGS 1488
I + ++N ++P F+ YE+ +P T PG + +V A+D D G + + Y+I G
Sbjct: 682 I-NVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 739
Query: 1489 QDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVED 1547
+ LF +D +G + + K D+ + H + V D P + V V + V +
Sbjct: 740 ---NTRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 795
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
+ +L S+ + P TE+ V + +D
Sbjct: 796 SVTNATLINEL-VRKSIEAPVTPNTEIADVSSPTSD 830
Score = 209 bits (533), Expect = 4e-53
Identities = 197/716 (27%), Positives = 316/716 (44%), Gaps = 56/716 (7%)
Query: 1997 LNDTLSYFLLNGTD---MFHMVQSAGVLQTRGVAFDREQ------QDTHELAVEVRDNRT 2047
L T+ + L+ T + + + G + T G DRE+ +D H EV
Sbjct: 78 LTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEH-CFYEVEVAIL 136
Query: 2048 PQRVAQGL-VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVT 2106
P + + + +R IED+NDN P F I + + +A D D+G NG
Sbjct: 137 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196
Query: 2107 YEFAEDYTYFRID-------PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE-- 2157
YE + F +D + + ++K D + + Y +KV DGG P S
Sbjct: 197 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAIL 256
Query: 2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPI--LH-TQARSPEGLRLIY---NIVEEE 2211
+V VT N ++P+F+ +V +PEN + T + LH T A E ++ + N+V
Sbjct: 257 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNI 316
Query: 2212 PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPT 2271
LF + TG++T+ PLD E H V A+D L + A V V V DVNDN P+
Sbjct: 317 ARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP-ARAMVLVNVTDVNDNVPS 375
Query: 2272 F------SQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
+ + T +SE +P T + + +D+D+ N V+ D + +
Sbjct: 376 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVF 433
Query: 2326 GSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYE 2385
+ + LDYE+ + + +K+ A D G PPL ++ + V D NDN P F Q
Sbjct: 434 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 493
Query: 2386 ANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKH 2445
++ E + G ++KV A D DS + + YL L + F ++ +G++++ +
Sbjct: 494 VSIPENNSPGIQLMKVSATDADSGPNAEINYL-LGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 2446 LDSSYNLRVGASD-GV--FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID 2502
+ Y + A D GV + V V+++ + N SP F + Y+ + EN V
Sbjct: 553 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 612
Query: 2503 LLAIDKDSGPYGTIDYTIINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
+ D D G + +I+++ ++ F+I + G I DRE +K A D
Sbjct: 613 ITVTDPDYGDNSAVTLSILDE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED 668
Query: 2562 GG--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSP---VIQVLAYDADEGQ 2616
GG R + V I + D NDN P F Y S + + +P V QV+A D D G
Sbjct: 669 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 728
Query: 2617 NADVTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
NA+V YS+ N DL E +T + K + +GL +KA D G P
Sbjct: 729 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHR----VLVKANDLGQP 780
Score = 207 bits (526), Expect = 2e-52
Identities = 187/656 (28%), Positives = 295/656 (44%), Gaps = 37/656 (5%)
Query: 2458 DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTID 2517
D +FR V + + N +P F + + EN+ + +K A+D D G G +
Sbjct: 138 DEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196
Query: 2518 YTIINKLASEKFSI--NPNG----QIATLQKLDRENSTERVIAIKVMARDGG--GRVAFC 2569
Y +I + P G Q+ ++LDRE V+ +KV DGG R +
Sbjct: 197 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKV--EDGGFPQRSSTA 254
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN--PE 2627
+++ +TD NDN P FK +E VSI N + V Q+ A DAD G+NA + +S +
Sbjct: 255 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 314
Query: 2628 DLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKV- 2686
++ + + +N TG++ +K+ L E + A DGG ++V V + V V
Sbjct: 315 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 374
Query: 2687 --SLPKFSEPLY-TFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLD 2743
+ P+ T E++P ++I ++ V +D V T + +
Sbjct: 375 SIDIRYIVNPVNDTVVLSENIPLNTKIALI-TVTDKDADHNGRVTCFTDHEIPFRLRPVF 433
Query: 2744 PDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
+ +++ +D+ESTK Y I ++A + + I+V D NDN PVF
Sbjct: 434 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 493
Query: 2804 AVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQEL 2863
+ EN G +++V+A D D+G + +++Y L D F++D +G +T +++L
Sbjct: 494 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE----FSLDRRTGMLTVVKKL 549
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E Y F ++A D+G L+S V VSI D+NDN+P F EY+ V EN
Sbjct: 550 DREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 608
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D + + + E D F I SQ G I + DRE Y
Sbjct: 609 TVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTG---VIRPNISFDREKQESYTF 662
Query: 2983 RVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGK---VHEDVFPGHFILKVSAT 3036
V A DG +S V I V+DVNDN P Y V PG + +V A
Sbjct: 663 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722
Query: 3037 DLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
D DT NA++ YS+ G + F +D TG +T + D + ++ KA D G
Sbjct: 723 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLG 778
Score = 201 bits (512), Expect = 1e-50
Identities = 181/660 (27%), Positives = 292/660 (44%), Gaps = 38/660 (5%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
++ I D NDNAP F + S+ ENS +D D+ Q I +
Sbjct: 146 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 205
Query: 2952 LGQFGI-SQVGDEW-RISSRKTLDREHTAKYLLRVTASDGKF---QASVTVEIFVLDVND 3006
G I + GD+ ++ +K LDRE Y+++V DG F ++ +++ V D ND
Sbjct: 206 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 265
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS----LHGPGAHEFKLDP 3062
N P + + E+ G + ++ ATD D NA+I +S + F L+
Sbjct: 266 NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNA 325
Query: 3063 HTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAP----RFF--PS 3116
TG +T LDRE L+ A+DGG +A + ++V DVNDN P R+ P
Sbjct: 326 TTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 385
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV----YSLPDSAEGHFSIDATTGVIRLE 3172
+ V + +N + T +A++ D D N +V + +P FS LE
Sbjct: 386 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS-----NQFLLE 440
Query: 3173 KPLQVRPQAPLELTVR--ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ ++ E ++ A+D G P PL+ + + V D PVF + +V +PE+
Sbjct: 441 NAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 3231 APPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTGILYVNASLDFETSPKYFL 3289
PG ++++++ + G + F LD RTG+L V LD E KY
Sbjct: 500 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLF 559
Query: 3290 SIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED 3349
+I L+ TV V+I D N++ P F + Y V EN + ++ TD D
Sbjct: 560 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 619
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHED 3409
NS +T S++ N FTI + G ++ + DRE+ SY+ ++A D G+
Sbjct: 620 YGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 677
Query: 3410 TDIAIQVADVNDNPPRF----FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR 3465
+ I V DVNDN P F + +Y + +P G+ V Q+I D D+ N +
Sbjct: 678 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA-EVRYS 735
Query: 3466 ITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
I GN F + + G + E +++ ++A+D G P L S+ V + V E
Sbjct: 736 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 795
Score = 199 bits (505), Expect = 7e-50
Identities = 190/663 (28%), Positives = 294/663 (44%), Gaps = 44/663 (6%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L + ++ D+N+N P F + V + ENS ++ + AA D D G++G Y L
Sbjct: 143 LVKIRFLIEDINDNA--PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 200
Query: 1073 AGT---GLAAFSINQDTGMIQTLAP--LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
GL + M Q + LDRE Y + V D G SS + + V
Sbjct: 201 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 260
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF---NITSGNYMGF 1184
TD NDN P + SI E+APVGTSV QL A D D K+ F N+ S
Sbjct: 261 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 320
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H L V D G + + + V+V + DVNDN P
Sbjct: 321 FHLNATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDI 378
Query: 1245 KLF------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT----YSIEDSDEEAFSID 1294
+ V L E + P++ + + +D D NGRVT + I FS
Sbjct: 379 RYIVNPVNDTVVLSENI-PLNT-KIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ 436
Query: 1295 LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
+ + + EY I + A D+G+PPL+ S L I+ + P+ F +++
Sbjct: 437 FLLENAAYLDYESTKEYAIKLL-AADAGKPPLNQSAMLFIK--VKDENDNAPV-FTQSFV 492
Query: 1355 SFTVMETDPVNHMVGVISV---EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
+ ++ E + + +S + P + G D +F +++ TG + + + LD
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 1412 RRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
+ Y T+ D G + + V +F+ I + N + P F Y+ VP++ +
Sbjct: 553 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGL 612
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
+ D D G + T+ + F +D +GV+ D S +T V D
Sbjct: 613 ITVTDPDYGDNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQES-YTFYVKAED 668
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFT----QLHYEASVPDTIAPGTELLQVRAMDADRG 1585
+ + VTI+V D N + P F YE +P T PGT + QV A+D D G
Sbjct: 669 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTG 727
Query: 1586 VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+NAEV YS++ GN+ F I+ G ITL +K D + H + VKA D G P L +
Sbjct: 728 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD--SLFS 785
Query: 1646 VII 1648
V+I
Sbjct: 786 VVI 788
Score = 195 bits (496), Expect = 7e-49
Identities = 190/760 (25%), Positives = 331/760 (43%), Gaps = 86/760 (11%)
Query: 1193 LLSTAQQLDREN------KDEHI---LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFS 1243
+ +T ++DRE +DEH +EV +L + + ++ I D+NDN P+F
Sbjct: 105 IFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAPLFP 161
Query: 1244 HKLFNVRLPERLSPVSPGPVYRLVAS-DLDEGLNGRVTYSIEDSDEEAFSIDLVTG---- 1298
+ N+ +PE + S Y L A+ D D G+NG Y + S + F +D++
Sbjct: 162 ATVINISIPENSAINSK---YTLPAAVDPDVGINGVQNYELIKS-QNIFGLDVIETPEGD 217
Query: 1299 -----VVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+V + ++ +K D G P S++ L + + F ET
Sbjct: 218 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETE 274
Query: 1354 YSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMD---FDIEKTTGSIVIAR 1406
++ E PV V + G F+ S ++ F + TTG I I
Sbjct: 275 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334
Query: 1407 PLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV---- 1462
PLD N+ L V +DG A + + + ++N + P ++ RY V DTV
Sbjct: 335 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPS-IDIRYIVNPVNDTVVLSE 393
Query: 1463 -----PGVELLRVQAIDQD-KGKSLIYTIHGSQDPGSASLFQLDP---SSGVLVTVGKLD 1513
+ L+ V D D G+ +T H F+L P + +L LD
Sbjct: 394 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-------FRLRPVFSNQFLLENAAYLD 446
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
S ++ + ++ D P + I V+D N + P FTQ S+P+ +PG +
Sbjct: 447 YES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 505
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
L++V A DAD G NAE++Y LL ++ F+++ G++T+ +KLD+ + T+ A+
Sbjct: 506 LMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 564
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
D G P TV + + + ++P+F+ +EY +PE++P + L++ P S
Sbjct: 565 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 624
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSY--QLKIRGSNMAGAFTDVMVVV 1746
VT + + N D F+++S +G+I D EK SY +K + V +
Sbjct: 625 AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 682
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN---PFVIHASDSDKEANSLLVYK 1803
+++D NDN P+F+ + Y +++ N F + A D+D N+ + Y
Sbjct: 683 NVVDVNDNKPVFIVPPYNYS-------YELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 735
Query: 1804 ILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP-VLFAPRPAQVIIHV 1862
I+ F ID G +T++ + D + + V +D G P LF+ V+I
Sbjct: 736 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFS-----VVIVN 790
Query: 1863 RDVNDSPPRFS--EQIYEVAIVGPIHPGMELLMVRASDED 1900
VN+S + ++ +I P+ P E+ V + D
Sbjct: 791 LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 180 bits (457), Expect = 2e-44
Identities = 154/580 (26%), Positives = 252/580 (43%), Gaps = 30/580 (5%)
Query: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
+ R+ Y + V + V + + D+NDN+P + + E+
Sbjct: 121 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 180
Query: 3032 KVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVA 3085
+A D D N Y L G E +L LDRE KD + +
Sbjct: 181 LPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKV 240
Query: 3086 KATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
K DGG RS A + + V D NDN P F + V++ +N V T V + A D D G
Sbjct: 241 KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 300
Query: 3144 ANAQVVYS----LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
NA++ +S + + A F ++ATTG+I +++PL +L V ASD G +
Sbjct: 301 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MP 357
Query: 3200 TLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGY 3253
V V+V + D +P + +V + E+ P T++ L T+T A+ G
Sbjct: 358 ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIA-LITVTDKDADHNGR 416
Query: 3254 RVVSGNEQGRFRLD---ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVN 3310
+ + FRL + +L A LD+E++ +Y + + + L+ + +
Sbjct: 417 VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 476
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D N++ P F Q + + EN G ++ VSATD D N++I Y L+G + F+
Sbjct: 477 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFS 535
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ + G L V K LDRE+ Y + A D+G PPL + + + + D NDN P F
Sbjct: 536 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 595
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE-GL 3489
Y V EN P V + ++DPD +N + ++ + F + ++
Sbjct: 596 YKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 3490 SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
R QE Y ++A D G SS V ++V + + P
Sbjct: 653 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 692
Score = 171 bits (434), Expect = 1e-41
Identities = 155/531 (29%), Positives = 244/531 (45%), Gaps = 37/531 (6%)
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHF 3160
+ED+NDNAP F + +++ +N+ + + + A DPD G N Y L S G
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 3161 SIDATTG----VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP 3216
I+ G + ++K L + + V+ D G P ST + VSV D P
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHP 268
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYR-----VVSGNEQGRFRLDARTG 3271
VF TE V +PE+AP GT V QL E +VS + F L+A TG
Sbjct: 269 VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG 328
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP----QFPQDPYS 3327
++ + LD E +P + L + S + V+VN+TDVN++ P ++ +P +
Sbjct: 329 LITIKEPLDREETPNHKLLVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVN 386
Query: 3328 TRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
V+ EN + I ++ TD+D N +T + + L+ A LD
Sbjct: 387 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 446
Query: 3386 REQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKV 3445
E Y++KL A D+G+PPL++ + I+V D NDN P F Q + ++ EN+ G ++
Sbjct: 447 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 506
Query: 3446 LQLILSDPDSPENGPPYSFRITKGNNG----SAFRVTPDGWLVTAEGLSRRAQEWYQLQI 3501
+++ +D DS GP G + S R T G L + L R ++ Y I
Sbjct: 507 MKVSATDADS---GPNAEINYLLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTI 561
Query: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQ 3561
A D+G+PPL+S +V V + +Q+ +P E V E+ + G VG I TD D
Sbjct: 562 LAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 621
Query: 3562 D--TLTYSLAEEETLGRHFSVGAPDGKI---IAAQGLPRGHYSFNVTVSDG 3607
D +T S+ +E F++ + G I I+ + Y+F V DG
Sbjct: 622 DNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 669
Score = 169 bits (427), Expect = 7e-41
Identities = 181/720 (25%), Positives = 298/720 (41%), Gaps = 98/720 (13%)
Query: 425 DRAHYQLHIRTSPGQASTVVVID--IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
+ Y++ + P + +V I I D N++APLF + + ++ EN + A
Sbjct: 125 EHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 184
Query: 483 TDRDHGENGYVTYSIAGPKALPFSIDPY-------LGIISTSKPMDYELMKRIYTFRVRA 535
D D G NG Y + + + F +D + + K +D E K Y +V+
Sbjct: 185 VDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDRE-EKDTYVMKVKV 242
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + + NDN P+F+E SI ++ PVG S+ + A D D +
Sbjct: 243 EDGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 301
Query: 596 NLKYE-----IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNY 648
N K +VS F LN +G+I++K P L + ++ L + ASDG
Sbjct: 302 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP---LDREETPNHKLLVLASDGGLMPA 358
Query: 649 ASPTTLNITVVKD--PHFEV-----PVT------------------------CDKTGVLT 677
+ +N+T V D P ++ PV D G +T
Sbjct: 359 RAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT 418
Query: 678 QFTKTILHF---------IGLQNQESSDEEFTSLSTYQI--------------------- 707
FT + F L+N D E T ++
Sbjct: 419 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 478
Query: 708 --NHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEGCFD 764
N P F F ++ + E+ L +++ATD D+G N ++ Y++ D E F
Sbjct: 479 DENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FS 535
Query: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
++ TG+LTV LD E + Y+ + D G P +S + V++ D NDN+P F
Sbjct: 536 LDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 595
Query: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Y+ + E+ T+ +T D D DN V ++L + F++ TG + DRE
Sbjct: 596 YKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE 655
Query: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP---PG 941
+ Y V+A D S + I + DVNDN P I LP PG
Sbjct: 656 KQESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 713
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLW 1000
TV+ + A D D G EVRY ++ G F +D TG + L + D + + +
Sbjct: 714 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVK 773
Query: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
A+D G+P +L V ++ L VNE++ + + + ++ T++ V++ D
Sbjct: 774 ANDLGQP---DSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 152 bits (383), Expect = 9e-36
Identities = 139/542 (25%), Positives = 245/542 (45%), Gaps = 40/542 (7%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + ++ + + T ++ V + D ND P+F V+I E+ P+ +
Sbjct: 228 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 287
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G+NA+ +++F N +F ++ T+G++T+ L+ H+L
Sbjct: 288 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 347
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP-------DSNDGTTYA 273
VLA S+G + A ++V+V P+I + P N
Sbjct: 348 VLA-------SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 400
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
L+ A+ D F+ + SN+F L + +++ L
Sbjct: 401 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVF--SNQFLLENAAYLDYESTKEYAIKLL 458
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA--FP 391
A +G P S + + ++ F ++ V + E + PG +++ V T A P
Sbjct: 459 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 518
Query: 392 N--LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVV 444
N + Y+L P + F L+ RTG++T K +D Y I P ++ V
Sbjct: 519 NAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 577
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP 504
+ I+D N+++P+F + Y + EN+P +V +T TD D+G+N VT SI
Sbjct: 578 FVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND-D 636
Query: 505 FSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMF 564
F+ID G+I + D E + YTF V+A D G R + + + ++NDN+P+F
Sbjct: 637 FTIDSQTGVIRPNISFDRE-KQESYTFYVKAED-GGRVSRSSSAKVTINVVDVNDNKPVF 694
Query: 565 EEVNCTGSIRQDWP---VGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
S P G + + A+D D N ++Y IV GN + F ++ +G I
Sbjct: 695 IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI 754
Query: 620 SL 621
+L
Sbjct: 755 TL 756
Score = 148 bits (374), Expect = 1e-34
Identities = 164/670 (24%), Positives = 279/670 (41%), Gaps = 67/670 (10%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL-REGNKDGVFSMNSYS 1709
+AP+F + + IPE+ + S L +A+ P YEL + N G+ + +
Sbjct: 156 NAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPE 215
Query: 1710 G----LISTQKKLDHEKISSYQLKIRGSNMAGAF----TDVMVVVDIIDENDNAPMFLKS 1761
G + QK+LD E+ +Y +K++ + G F + ++ V + D NDN P+F ++
Sbjct: 216 GDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNHPVFKET 273
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYK---ILEPEALKFFKIDPS 1818
I E AP+ + + +HA+D+D N+ + + ++ A + F ++ +
Sbjct: 274 EIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 326
Query: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
G +TI +D E P+ + V D G P A V+++V DVND+ P +
Sbjct: 327 TGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY-- 380
Query: 1879 VAIVGPIHPGM----------ELLMVRASDEDSEVNYSIKTGNADEA-VTIHPVTGSISV 1927
IV P++ + ++ ++ +D+D++ N + E + PV + +
Sbjct: 381 --IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 1928 L-NPAFLGLS-------RKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
L N A+L + L A +A++ I + D + F Q ++ E
Sbjct: 439 LENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 498
Query: 1980 NLQDRKALVILGAQGNHLNDTLSYFLLNGTDM---FHMVQSAGVLQTRGVAFDREQQDTH 2036
N L+ + A L G D F + + G+L T DRE++D +
Sbjct: 499 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML-TVVKKLDREKEDKY 557
Query: 2037 ELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ +DN P + V VSI D NDN P F H Y + + + ++ TD
Sbjct: 558 LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTD 617
Query: 2097 EDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSE 2156
D G N AVT ++ F ID G I FD + Y V A DGG S S
Sbjct: 618 PDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 677
Query: 2157 EEVLVTV--RNKSNPLFQSP----YYKVRVPENI--TLYTPILHTQARSPEGLRLIYNIV 2208
+V + V N + P+F P Y++ +P T+ ++ + + Y+IV
Sbjct: 678 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 737
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL--GSFSEATVEVLVEDVN 2266
LF D +TG +T+ D H V+A D FS V + V +
Sbjct: 738 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESV 797
Query: 2267 DNPPTFSQLV 2276
N ++LV
Sbjct: 798 TNATLINELV 807
Score = 111 bits (277), Expect = 2e-23
Identities = 165/720 (22%), Positives = 281/720 (39%), Gaps = 103/720 (14%)
Query: 127 ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA 186
E+ L ++ I D ND PLF ++I E+ + S A D D+G N Y
Sbjct: 139 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 198
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR--MRKISEGNGFGSLAALVV 244
+F + + T G + EL D M+ E GF
Sbjct: 199 LIKSQNIFGLDV---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQ------ 249
Query: 245 HVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDANSS-GAEVESVEVVGGDPGK 298
R AI V VT D+ND T V + N+ G V + D G+
Sbjct: 250 ------RSSTAILQVSVT--DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 301
Query: 299 HFKAIKSYAR------------SNEFSLVSVKD-INWMEYLHGFNLSLQARSGSGPYFYS 345
+ K S++ + L+++K+ ++ E + L L + G P
Sbjct: 302 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM 361
Query: 346 QIRGFHLPPSKLSSLKFEKAVYRVQ----LSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPS 400
+ + S+ V V LSE P +++ ++ VT + V +
Sbjct: 362 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 421
Query: 401 SENVGFKLN---ARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCN 452
+ F+L + L+ +D+ Y + + + P S ++ I + D N
Sbjct: 422 DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 481
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYL 511
++AP+F +S ++ EN PG ++ V+ATD D G N + Y + GP A P FS+D
Sbjct: 482 DNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT 540
Query: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
G+++ K +D E + Y F + A D G P V++F+ + + NDN P+F
Sbjct: 541 GMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKF 598
Query: 572 SIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631
+ ++ P ++ ++ D D N + +E + F ++ +GVI RP I+
Sbjct: 599 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDRE 655
Query: 632 QPTSYSLKITASDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQ 690
+ SY+ + A DG + ++ +T+ V D + PV
Sbjct: 656 KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPV---------------------- 693
Query: 691 NQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKL 750
+ + Y +E VL S T + ++ A D D G N ++
Sbjct: 694 --------------FIVPPYNYSYE-------LVLPSTNPGTVVFQVIAVDNDTGMNAEV 732
Query: 751 VYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNV 810
Y I GN F I+ ETG +T+ D + + V DLG P S + ++ VN+
Sbjct: 733 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNL 791
Score = 65.1 bits (157), Expect = 1e-09
Identities = 51/176 (28%), Positives = 85/176 (48%), Gaps = 32/176 (18%)
Query: 108 NREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
+RE ++SYT ++A + + + +V ++++D ND KP+F P Y + +P +P
Sbjct: 653 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP 712
Query: 167 ---ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ +V A D D G NAE Y+ NTR ++FAI +G +T+ K +VT G H +
Sbjct: 713 GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLHRVL 771
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL 276
V A D L +P ++ SVV+ N+ T AT++
Sbjct: 772 VKAND------------------------LGQPDSLFSVVIVNLFVNESVTNATLI 803
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 248 bits (632), Expect = 1e-64
Identities = 199/664 (29%), Positives = 301/664 (45%), Gaps = 34/664 (5%)
Query: 2763 YQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAI 2822
Y+++V + ++ LV + + D+NDN P+F A + EN + + A+
Sbjct: 108 YEVEV---AILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV 164
Query: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESG----WITTLQELDCETCQTYHFHVVAY 2878
D D G +G +Y L N+ L I++ G + +ELD E TY V
Sbjct: 165 DPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVE 222
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
D G Q SS A++QVS+TD NDN P F E S+ EN+ G V L DADI E
Sbjct: 223 DGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGEN 281
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-ASVTV 2997
+ + + + I+ ++ LDRE T + L V ASDG A V
Sbjct: 282 AKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMV 341
Query: 2998 EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI------LKVSATDLDTDTNAQITYSLH 3051
+ V DVNDN P V++ V I ++ TD D D N ++T
Sbjct: 342 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD 401
Query: 3052 GPGAHE--FKLDPHTGE---LTTLTALDRERKDVFNLVAKATDGGGRSCQ--ADITLHVE 3104
HE F+L P L T LD E + + A D G A + + V+
Sbjct: 402 ----HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
Query: 3105 DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDA 3164
D NDNAP F S V++ +N + + V A D D G NA++ Y L A FS+D
Sbjct: 458 DENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDC 517
Query: 3165 TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS 3224
TG++ + K L + T+ A D G P PL++ TV VS++ D PVF + E++
Sbjct: 518 RTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 3225 VQVPEDAPPGTEVLQLATLTRPG-AEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFET 3283
VPE+ P V L T+T P + + + +E F +D++TG++ N S D E
Sbjct: 577 FYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 3284 SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR---VLENALVGDVI 3340
Y ++ S S V +N+ DVN+++P F P + VL + G V+
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVV 695
Query: 3341 LTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
V A D D +N+++ YS++GGN F I + G + + + D + + ++A D
Sbjct: 696 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Query: 3401 SGQP 3404
GQP
Sbjct: 756 LGQP 759
Score = 246 bits (627), Expect = 5e-64
Identities = 208/705 (29%), Positives = 324/705 (45%), Gaps = 38/705 (5%)
Query: 2253 FSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
F + L+ED+NDN P F V SI E + A D D G N +Y+++
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2313 ED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVN 2368
+ G DV + + ++ +ELD E + + +KV+ D G P + ++ V+
Sbjct: 180 KSQNIFGLDVIETPE-GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2369 VSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDR 2425
V+D NDN P F++ + E ++ E A G V ++ A D D + +++ + ++S R
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQH 2484
F +N+++G+I++ + ++ L V ASD G+ A V +N T+ N P
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2485 LY------EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNG-QI 2537
L+EN + TK+ + DKD+ G + +++ + N +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2538 ATLQKLDRENSTERVIAIKVMARDGG----GRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
T LD E++ E AIK++A D G + A +K+ DENDN P F S TVS
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE 2653
I N S + +V A DAD G NA + Y + P+ ++ TG++ V L +
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD--APPEFSLDCRTGMLTVVKKLDREK 532
Query: 2654 NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV 2713
F I A+D G P S V V + ++ + + P F+ Y F PE+LP +G++
Sbjct: 533 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592
Query: 2714 KAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
V D S V + + N D F++D TGVI+ D E + Y V A
Sbjct: 593 -TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 649
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
S V I V DVNDN+PVF P Y+ VL P GT V QV A+D DTG +
Sbjct: 650 RVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMN 708
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
+V Y + G N +LFAID E+G IT +++ D + V A D GQ L S
Sbjct: 709 AEVRYSI---VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSV 765
Query: 2890 ALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
+V + + + NA +E R S P +A + + +D
Sbjct: 766 VIVNLFVNESVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 241 bits (615), Expect = 1e-62
Identities = 198/637 (31%), Positives = 300/637 (47%), Gaps = 43/637 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVY-VIADGNEEGCFDIELETG----LLTVA 775
+I + E+ IN+ AA DPD G NG Y +I N G IE G L V
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQ 204
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ V V D G PQ+SS +L V+V D NDN P F +++I E+ V
Sbjct: 205 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 264
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD +N ++ ++ + F L+ TG + + LDRE P +
Sbjct: 265 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 324
Query: 891 LKVEARD---QPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPG 941
L V A D P++ L +VT DVNDN P + + + + E++P
Sbjct: 325 LLVLASDGGLMPARAMVLVNVT-------DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV-DLMTGALILERE--LDFERRAGYNLS 998
T + + +D D G R FR+ + + +LE LD+E Y +
Sbjct: 378 TKIALITVTDKDADHNG--RVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
L A+D G+P ++ + + V D N+N P SFV + NSP G Q+ V+A D
Sbjct: 436 LLAADAGKPPLNQS-AMLFIKVKDENDNA-PVFTQSFVTVSIPENNSP-GIQLTKVSAMD 492
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSG + ++ Y L FS++ TGM+ + LDRE Y T+LA D G PL+
Sbjct: 493 ADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT 551
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
S V++ + D NDN P + + + E+ P +V + DPD +T +I
Sbjct: 552 SNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILD 611
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
N F I TG++ DRE ++ + V D G S S+++V + ++DVNDN
Sbjct: 612 EN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDN 669
Query: 1239 PPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLV 1296
P+F N L +PG V++++A D D G+N V YSI + + F+ID
Sbjct: 670 KPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQE 729
Query: 1297 TG---VVSSSSTFTAGEYNILTIKATDSGQPPLSASV 1330
TG ++ G + +L +KA D GQP SV
Sbjct: 730 TGNITLMEKCDVTDLGLHRVL-VKANDLGQPDSLFSV 765
Score = 239 bits (609), Expect = 6e-62
Identities = 191/703 (27%), Positives = 323/703 (45%), Gaps = 34/703 (4%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH 869
++D NDNAP FP ++I E++ + + D D NG Y L+ F L
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 870 PLTG-------ELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNS 922
+ +L+V LDRE + Y++KV+ D Q S L +++ D NDN
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNH 246
Query: 923 PQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY----VLMDGAHGTFRVDLMT 978
P + +PE+ P GT +T L A+D D+G ++ + ++ + A F ++ T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
G + ++ LD E + L + ASDGG AR V V V DVN+N+ V+
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAM---VLVNVTDVNDNVPSIDIRYIVNP 363
Query: 1039 GQ----VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
+ EN P T++ ++ D D+ +G + F + + +++T A
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423
Query: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
LD E Y + +LA D G PL+ ++I+V D NDN P +Q+ SI E+ G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
+ ++ A D DS K+ + + + F + TG+L+ ++LDRE +D+++ +
Sbjct: 484 QLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
DNG P L S V V I+D NDN P+F+H +N +PE L G V + +D D G
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLP--RHGTVGLITVTDPDYG 600
Query: 1275 LNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPLSASVRL 1332
N VT SI D +++ F+ID TGV+ + +F + T +KA D G+ S+S ++
Sbjct: 601 DNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 659
Query: 1333 HIEWIPW--PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGL---FWFNISGG 1387
I + +P I + Y + T+P + VI+V+ G+ ++I GG
Sbjct: 660 TINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1388 DKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSR--TIATQVHIFMIANINHHR 1445
+ F I++ TG+I + D + + V+ D + ++ + V + + N +
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1446 PQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGS 1488
+ P E+ V + D K L+ + G+
Sbjct: 779 ATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821
Score = 228 bits (580), Expect = 1e-58
Identities = 208/765 (27%), Positives = 336/765 (43%), Gaps = 83/765 (10%)
Query: 425 DRAHYQLHIRTSPGQASTVVVID--IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
+ Y++ + P + +V I I D N++APLF + + ++ EN + A
Sbjct: 104 EHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 163
Query: 483 TDRDHGENGYVTYSIAGPKALPFSID-------PYLGIISTSKPMDYELMKRIYTFRVRA 535
D D G NG Y + + + F +D + + K +D E K Y +V+
Sbjct: 164 VDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDRE-EKDTYVMKVKV 221
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + + NDN P+F+E SI ++ PVG S+ + A D D +
Sbjct: 222 EDGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 596 NLKY-----EIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNY 648
N K +VS F LN +G+I++K P L + ++ L + ASDG
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP---LDREETPNHKLLVLASDGGLMPA 337
Query: 649 ASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQIN 708
+ +N+T V D ++ + I
Sbjct: 338 RAMVLVNVTDVND---------------------------------------NVPSIDIR 358
Query: 709 HYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELE 768
+ D ++ + E++P+NT +A + TD DA NG++ +
Sbjct: 359 YIVNPVND----TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 769 TGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLT 828
LL AA LDYE+T Y + + D G P + +L + VKD NDNAP F ++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 829 ISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSP--TEKFSLHPLTGELVVTGHLDRESE 886
I E+ G + +++ DADS N ++ Y LL P +FSL TG L V LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 887 PRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF 946
+Y+ + A+D L S + +++ D NDNSP VPE+LP +
Sbjct: 534 DKYLFTILAKDNGVP--PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 947 LDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGR 1006
+ +DPD G V ++D + F +D TG + D E++ Y + A DGGR
Sbjct: 592 ITVTDPDYGDNSAVTLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650
Query: 1007 PLARRTLCHVEVIVLDVNEN----LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSG 1062
++R + V + V+DVN+N + PP S+ V ++ GT V V A D+D+G
Sbjct: 651 -VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSY---ELVLPSTNPGTVVFQVIAVDNDTG 706
Query: 1063 LDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV-PLSSVT 1121
++ E++Y + G F+I+Q+TG I + D + + V A D G L SV
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
V + V ++ N +++ V +APV + D P S
Sbjct: 767 IVNLFVNESVTNATLINELV---RKSTEAPVTPNTEIADVSSPTS 808
Score = 220 bits (561), Expect = 2e-56
Identities = 219/813 (26%), Positives = 365/813 (44%), Gaps = 83/813 (10%)
Query: 872 TGELVVTG-HLDRES-------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
TGE+ TG +DRE + +VE P ++F + + +ED+NDN+P
Sbjct: 81 TGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAP 137
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM------ 977
+ +PE+ + T A DPD+G G Y L+ + F +D++
Sbjct: 138 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-SQNIFGLDVIETPEGD 196
Query: 978 -TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFV 1036
LI+++ELD E + Y + + DGG P R + ++V V D N+N P F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDN--HPVFKETE 253
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYF---LRAGTGLAAFSINQDTGMIQTLA 1093
+ + EN+P GT V + A D D G + ++ + L + F +N TG+I
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMS-QAVFYP-----SIQ 1147
PLDRE + L VLA D G +P ++ V + VTD NDN P + + + P +
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG---LLSTAQQLDREN 1204
E+ P+ T + + D D+ G++T ++ F + PV LL TA LD E+
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLETAAYLDYES 428
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY 1264
E+ +++ D G+P L ++ + + + D NDN P+F+ V +PE SP +
Sbjct: 429 TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLT 486
Query: 1265 RLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG---VVSSSSTFTAGEYNILTIKATDS 1321
++ A D D G N ++ Y + FS+D TG VV +Y + TI A D+
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKY-LFTILAKDN 545
Query: 1322 GQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRP 1377
G PPL+++V + + I S + F Y+F V E P + VG+I+V G
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1378 GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVH 1434
+I D++ DF I+ TG I D ++ +Y V+ DG SR+ + +V
Sbjct: 603 SAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1435 IFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGS 1488
I + ++N ++P F+ YE+ +P T PG + +V A+D D G + + Y+I G
Sbjct: 661 I-NVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1489 QDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVED 1547
+ LF +D +G + + K D+ + H + V D P + V V + V +
Sbjct: 719 ---NTRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINA 1607
+ +L S + P TE+ V + +D + +L G +
Sbjct: 775 SVTNATLINEL-VRKSTEAPVTPNTEIADVSSPTSD-------YVKILVAAVAGTITVVV 826
Query: 1608 LLGIITLAQKLDQANHAPHTLTVKAEDQGSPQW 1640
++ I + + APH + Q S +W
Sbjct: 827 VIFITAVV----RCRQAPHLKAAQKNKQNS-EW 854
Score = 219 bits (557), Expect = 6e-56
Identities = 192/633 (30%), Positives = 291/633 (45%), Gaps = 58/633 (9%)
Query: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI-------YSL 2726
LV +R + + P F + S PE+ S+ + AV DP + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV---DPDVGINGVQNYEL 178
Query: 2727 VRGT---------TPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
++ TPE +K + V+K +D E Y + V
Sbjct: 179 IKSQNIFGLDVIETPEGDK---------MPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 229
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
S + + V D NDN PVF+ + + EN PVGTSV Q+ A D D G + ++ + S
Sbjct: 230 SSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 289
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSIT 2897
+ LF +++ +G IT + LD E + V+A D G + ++A+V V++T
Sbjct: 290 NLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVT 346
Query: 2898 DENDNAP----RFASEEYRGSVV--ENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
D NDN P R+ +VV EN +A + D D ++ N +VTC+ P
Sbjct: 347 DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD-ADHNGRVTCFTDHEIP 405
Query: 2952 LGQFGISQV-GDEWRISSRKTLDREHTAKYLLRVTASD-GK--FQASVTVEIFVLDVNDN 3007
F + V +++ + + LD E T +Y +++ A+D GK S + I V D NDN
Sbjct: 406 ---FRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
+P +Q T + E+ PG + KVSA D D+ NA+I Y L EF LD TG L
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGML 522
Query: 3068 TTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDN 3125
T + LDRE++D + A D G +++T+ V D NDN+P F + V +N
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 3126 TTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL 3185
V ++ DPD G N+ V S+ D + F+ID+ TGVIR Q
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDEND-DFTIDSQTGVIRPNISFDREKQESYTF 641
Query: 3186 TVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL----NTEHSVQVPEDAPPGTEVLQLA 3241
V+A D G + S+ VT++VV + D PVF+ N + + +P PGT V Q+
Sbjct: 642 YVKAED-GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVI 699
Query: 3242 TL---TRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ T AE Y +V GN + F +D TG
Sbjct: 700 AVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETG 731
Score = 208 bits (530), Expect = 8e-53
Identities = 189/660 (28%), Positives = 296/660 (44%), Gaps = 45/660 (6%)
Query: 2458 DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTID 2517
D +FR V + + N +P F + + EN+ + +K A+D D G G +
Sbjct: 117 DEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 2518 YTIINKLASEKFSI--NPNG----QIATLQKLDRENSTERVIAIKVMARDGG--GRVAFC 2569
Y +I + P G Q+ ++LDRE V+ +KV DGG R +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKV--EDGGFPQRSSTA 233
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN--PE 2627
+++ +TD NDN P FK +E VSI N + V Q+ A DAD G+NA + +S +
Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 2628 DLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKV- 2686
++ + + +N TG++ +K+ L E + A DGG ++V V + V V
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 2687 --SLPKFSEPLY-TFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLD 2743
+ P+ T E++P ++I ++ V +D V T + +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALI-TVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 2744 PDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
+ +++ +D+ESTK Y I ++A + + I+V D NDN PVF
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 2804 AVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQEL 2863
+ EN G + +V+A+D D+G + +++Y L D F++D +G +T +++L
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE----FSLDCRTGMLTVVKKL 528
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E Y F ++A D+G L+S V VSI D+NDN+P F EY V EN
Sbjct: 529 DREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D + + + E D F I SQ G I + DRE Y
Sbjct: 588 TVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTG---VIRPNISFDREKQESYTF 641
Query: 2983 RVTASDG---KFQASVTVEIFVLDVNDNSP-------QCSQLLYTGKVHEDVFPGHFILK 3032
V A DG +S V I V+DVNDN P CS L V PG + +
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL----VLPSTNPGTVVFQ 697
Query: 3033 VSATDLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
V A D DT NA++ YS+ G + F +D TG +T + D + ++ KA D G
Sbjct: 698 VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLG 757
Score = 207 bits (528), Expect = 1e-52
Identities = 193/699 (27%), Positives = 309/699 (44%), Gaps = 53/699 (7%)
Query: 2011 MFHMVQSAGVLQTRGVAFDREQ------QDTHELAVEVRDNRTPQRVAQGL-VRVSIEDV 2063
+ + + G + T G DRE+ +D H EV P + + + +R IED+
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEH-CFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 2064 NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRID---- 2119
NDN P F I + + +A D D+G NG YE + F +D
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192
Query: 2120 ---PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE--EVLVTVRNKSNPLFQSP 2174
+ + ++K D + + Y +KV DGG P S +V VT N ++P+F+
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252
Query: 2175 YYKVRVPENITLYTPI--LH-TQARSPEGLRLIY---NIVEEEPLMLFTTDFKTGVLTVT 2228
+V +PEN + T + LH T A E ++ + N+V LF + TG++T+
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 2229 GPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTF------SQLVYTTSIS 2282
PLD E H V A+D L + A V V V DVNDN P+ + + T +S
Sbjct: 313 EPLDREETPNHKLLVLASDGGLMP-ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2283 EGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQ 2342
E +P T + + +D+D+ N V+ D + + + + T LDYE+
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYEST 429
Query: 2343 QHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQ 2402
+ + +K+ A D G PPL ++ + V D NDN P F Q ++ E + G + KV
Sbjct: 430 KEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVS 489
Query: 2403 AIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GV- 2460
A+D DS +++ YL L + F ++ +G++++ + + Y + A D GV
Sbjct: 490 AMDADSGPNAKINYL-LGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 2461 -FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
+ V V+++ + N SP F + Y + EN V + D D G + +
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 2520 IINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARDGG--GRVAFCTVKIILT 2576
I+++ ++ F+I + G I DRE +K A DGG R + V I +
Sbjct: 609 ILDE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AEDGGRVSRSSSAKVTINVV 664
Query: 2577 DENDNPPQFKASEYTVSIQSNVSKDSP---VIQVLAYDADEGQNADVTYSV---NPEDLV 2630
D NDN P F S + + +P V QV+A D D G NA+V YS+ N DL
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 2631 KDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
E +T + K + +GL +KA D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHR----VLVKANDLGQP 759
Score = 201 bits (510), Expect = 2e-50
Identities = 181/660 (27%), Positives = 292/660 (44%), Gaps = 38/660 (5%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
++ I D NDNAP F + S+ ENS +D D+ Q I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 2952 LGQFGI-SQVGDEW-RISSRKTLDREHTAKYLLRVTASDGKF---QASVTVEIFVLDVND 3006
G I + GD+ ++ +K LDRE Y+++V DG F ++ +++ V D ND
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 244
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS----LHGPGAHEFKLDP 3062
N P + + E+ G + ++ ATD D NA+I +S + F L+
Sbjct: 245 NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNA 304
Query: 3063 HTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAP----RFF--PS 3116
TG +T LDRE L+ A+DGG +A + ++V DVNDN P R+ P
Sbjct: 305 TTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV----YSLPDSAEGHFSIDATTGVIRLE 3172
+ V + +N + T +A++ D D N +V + +P FS LE
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS-----NQFLLE 419
Query: 3173 KPLQVRPQAPLELTVR--ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ ++ E ++ A+D G P PL+ + + V D PVF + +V +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 3231 APPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTGILYVNASLDFETSPKYFL 3289
PG ++ +++ + + G + F LD RTG+L V LD E KY
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 3290 SIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED 3349
+I L+ TV V+I D N++ P F + Y+ V EN + ++ TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHED 3409
NS +T S++ N FTI + G ++ + DRE+ SY+ ++A D G+
Sbjct: 599 YGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 3410 TDIAIQVADVNDNPPRFF----QLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR 3465
+ I V DVNDN P F +Y + +P G+ V Q+I D D+ N +
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNA-EVRYS 714
Query: 3466 ITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
I GN F + + G + E +++ ++A+D G P L S+ V + V E
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 199 bits (506), Expect = 5e-50
Identities = 190/663 (28%), Positives = 292/663 (44%), Gaps = 44/663 (6%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L + ++ D+N+N P F + V + ENS ++ + AA D D G++G Y L
Sbjct: 122 LVKIRFLIEDINDNA--PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 1073 AGT---GLAAFSINQDTGMIQTLAP--LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
GL + M Q + LDRE Y + V D G SS + + V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF---NITSGNYMGF 1184
TD NDN P + SI E+APVGTSV QL A D D K+ F N+ S
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H L V D G + + + V+V + DVNDN P
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDI 357
Query: 1245 KLF------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT----YSIEDSDEEAFSID 1294
+ V L E + P++ + + +D D NGRVT + I FS
Sbjct: 358 RYIVNPVNDTVVLSENI-PLNT-KIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ 415
Query: 1295 LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
+ + + EY I + A D+G+PPL+ S L I+ + P+ F +++
Sbjct: 416 FLLETAAYLDYESTKEYAIKLL-AADAGKPPLNQSAMLFIK--VKDENDNAPV-FTQSFV 471
Query: 1355 SFTVMETDPVNHM---VGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
+ ++ E + V + + P + G D +F ++ TG + + + LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1412 RRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
+ Y T+ D G + + V +F+ I + N + P F Y VP++ +
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
+ D D G + T+ + F +D +GV+ D S +T V D
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQES-YTFYVKAED 647
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRF----TQLHYEASVPDTIAPGTELLQVRAMDADRG 1585
+ + VTI+V D N + P F + YE +P T PGT + QV A+D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTG 706
Query: 1586 VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+NAEV YS++ GN+ F I+ G ITL +K D + H + VKA D G P L +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD--SLFS 764
Query: 1646 VII 1648
V+I
Sbjct: 765 VVI 767
Score = 196 bits (498), Expect = 4e-49
Identities = 190/760 (25%), Positives = 332/760 (43%), Gaps = 86/760 (11%)
Query: 1193 LLSTAQQLDREN------KDEHI---LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFS 1243
+ +T ++DRE +DEH +EV +L + + ++ I D+NDN P+F
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAPLFP 140
Query: 1244 HKLFNVRLPERLSPVSPGPVYRLVAS-DLDEGLNGRVTYSIEDSDEEAFSIDLVTG---- 1298
+ N+ +PE + S Y L A+ D D G+NG Y + S + F +D++
Sbjct: 141 ATVINISIPENSAINSK---YTLPAAVDPDVGINGVQNYELIKS-QNIFGLDVIETPEGD 196
Query: 1299 -----VVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+V + ++ +K D G P S++ L + + F ET
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETE 253
Query: 1354 YSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMD---FDIEKTTGSIVIAR 1406
++ E PV V + G F+ S ++ F + TTG I I
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 1407 PLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV---- 1462
PLD N+ L V +DG A + + + ++N + P ++ RY V DTV
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPS-IDIRYIVNPVNDTVVLSE 372
Query: 1463 -----PGVELLRVQAIDQD-KGKSLIYTIHGSQDPGSASLFQLDP---SSGVLVTVGKLD 1513
+ L+ V D D G+ +T H F+L P + +L T LD
Sbjct: 373 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-------FRLRPVFSNQFLLETAAYLD 425
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
S ++ + ++ D P + I V+D N + P FTQ S+P+ +PG +
Sbjct: 426 YES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
L +V AMDAD G NA+++Y LL ++ F+++ G++T+ +KLD+ + T+ A+
Sbjct: 485 LTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
D G P TV + + + ++P+F+ +EY +PE++P + L++ P S
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSY--QLKIRGSNMAGAFTDVMVVV 1746
VT + + N D F+++S +G+I D EK SY +K + V +
Sbjct: 604 AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN---PFVIHASDSDKEANSLLVYK 1803
+++D NDN P+F+ + + Y +++ N F + A D+D N+ + Y
Sbjct: 662 NVVDVNDNKPVFI-------VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1804 ILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP-VLFAPRPAQVIIHV 1862
I+ F ID G +T++ + D + + V +D G P LF+ V+I
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFS-----VVIVN 769
Query: 1863 RDVNDSPPRFS--EQIYEVAIVGPIHPGMELLMVRASDED 1900
VN+S + ++ + P+ P E+ V + D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (448), Expect = 3e-43
Identities = 153/580 (26%), Positives = 250/580 (43%), Gaps = 30/580 (5%)
Query: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
+ R+ Y + V + V + + D+NDN+P + + E+
Sbjct: 100 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 159
Query: 3032 KVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVA 3085
+A D D N Y L G E +L LDRE KD + +
Sbjct: 160 LPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKV 219
Query: 3086 KATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
K DGG RS A + + V D NDN P F + V++ +N V T V + A D D G
Sbjct: 220 KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 279
Query: 3144 ANAQVVYS----LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
NA++ +S + + A F ++ATTG+I +++PL +L V ASD G +
Sbjct: 280 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MP 336
Query: 3200 TLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGY 3253
V V+V + D +P + +V + E+ P T++ L T+T A+ G
Sbjct: 337 ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIA-LITVTDKDADHNGR 395
Query: 3254 RVVSGNEQGRFRLD---ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVN 3310
+ + FRL + +L A LD+E++ +Y + + + L+ + +
Sbjct: 396 VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 455
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D N++ P F Q + + EN G + VSA D D N+ I Y L+G + F+
Sbjct: 456 VKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFS 514
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ + G L V K LDRE+ Y + A D+G PPL + + + + D NDN P F
Sbjct: 515 LDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 574
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE-GL 3489
Y+ V EN P V + ++DPD +N + ++ + F + ++
Sbjct: 575 YNFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 3490 SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
R QE Y ++A D G SS V ++V + + P
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Score = 169 bits (429), Expect = 4e-41
Identities = 153/529 (28%), Positives = 241/529 (45%), Gaps = 33/529 (6%)
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHF 3160
+ED+NDNAP F + +++ +N+ + + + A DPD G N Y L S G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 3161 SIDATTG----VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP 3216
I+ G + ++K L + + V+ D G P ST + VSV D P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHP 247
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYR-----VVSGNEQGRFRLDARTG 3271
VF TE V +PE+AP GT V QL E +VS + F L+A TG
Sbjct: 248 VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG 307
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP----QFPQDPYS 3327
++ + LD E +P + L + S + V+VN+TDVN++ P ++ +P +
Sbjct: 308 LITIKEPLDREETPNHKLLVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVN 365
Query: 3328 TRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
V+ EN + I ++ TD+D N +T + + L+ A LD
Sbjct: 366 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3386 REQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKV 3445
E Y++KL A D+G+PPL++ + I+V D NDN P F Q + ++ EN+ G ++
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3446 LQLILSDPDSPENGPPYSFRITKGNNGSA-FRVT-PDGWLVTAEGLSRRAQEWYQLQIQA 3503
++ D DS GP G + F + G L + L R ++ Y I A
Sbjct: 486 TKVSAMDADS---GPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 3504 SDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD- 3562
D+G+PPL+S +V V + +Q+ +P E V E+ + G VG I TD D D
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 3563 -TLTYSLAEEETLGRHFSVGAPDGKI---IAAQGLPRGHYSFNVTVSDG 3607
+T S+ +E F++ + G I I+ + Y+F V DG
Sbjct: 603 SAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648
Score = 166 bits (419), Expect = 6e-40
Identities = 157/630 (24%), Positives = 271/630 (43%), Gaps = 79/630 (12%)
Query: 419 KLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPP 473
K +D ++ Y + ++ G ++ ++ + + D N++ P+F + + ++ EN P
Sbjct: 205 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 264
Query: 474 GTSVLAVTATDRDHGENGYVTYS----IAGPKALPFSIDPYLGIISTSKPMDYELMKRIY 529
GTSV + ATD D GEN + +S ++ F ++ G+I+ +P+D E +
Sbjct: 265 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN-H 323
Query: 530 TFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFE------EVNCTGSIRQDWPVGKSI 583
V ASD G R + + + ++NDN P + VN T + ++ P+ I
Sbjct: 324 KLLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKI 380
Query: 584 MTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITAS 643
++ D D N + + +E+ + FS L+ L Y++K+ A+
Sbjct: 381 ALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY-LDYESTKEYAIKLLAA 439
Query: 644 D-GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702
D GK + + + VKD + PV FT++ +
Sbjct: 440 DAGKPPLNQSAMLFIKVKDENDNAPV----------FTQSFV------------------ 471
Query: 703 STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEG 761
++ + E+ L +++A D D+G N K+ Y++ D E
Sbjct: 472 ------------------TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE- 512
Query: 762 CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFP 821
F ++ TG+LTV LD E + Y+ + D G P +S + V++ D NDN+P F
Sbjct: 513 -FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 822 PGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881
Y + E+ T+ +T D D DN V ++L + F++ TG +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP-- 939
DRE + Y V+A D S + I + DVNDN P I + LP
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST 689
Query: 940 -PGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNL 997
PGTV+ + A D D G EVRY ++ G F +D TG + L + D + +
Sbjct: 690 NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 998 SLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
+ A+D G+P +L V ++ L VNE++
Sbjct: 750 LVKANDLGQP---DSLFSVVIVNLFVNESV 776
Score = 152 bits (384), Expect = 7e-36
Identities = 138/542 (25%), Positives = 246/542 (45%), Gaps = 40/542 (7%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + ++ + + T ++ V + D ND P+F V+I E+ P+ +
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G+NA+ +++F N +F ++ T+G++T+ L+ H+L
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP-------DSNDGTTYA 273
VLA S+G + A ++V+V P+I + P N
Sbjct: 327 VLA-------SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
L+ A+ D F+ + SN+F L + +++ L
Sbjct: 380 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVF--SNQFLLETAAYLDYESTKEYAIKLL 437
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA--FP 391
A +G P S + + ++ F ++ V + E + PG ++ V A P
Sbjct: 438 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 392 N--LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVV 444
N + Y+L P + F L+ RTG++T K +D Y I P ++ V
Sbjct: 498 NAKINYLLGPDAP-PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 556
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP 504
+ I+D N+++P+F + Y+ + EN+P +V +T TD D+G+N VT SI
Sbjct: 557 FVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND-D 615
Query: 505 FSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMF 564
F+ID G+I + D E + YTF V+A D G R + + + ++NDN+P+F
Sbjct: 616 FTIDSQTGVIRPNISFDRE-KQESYTFYVKAED-GGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 565 --EEVNCTGS-IRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
NC+ + G + + A+D D N ++Y IV GN + F ++ +G I
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI 733
Query: 620 SL 621
+L
Sbjct: 734 TL 735
Score = 144 bits (364), Expect = 1e-33
Identities = 163/670 (24%), Positives = 276/670 (41%), Gaps = 67/670 (10%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL-REGNKDGVFSMNSYS 1709
+AP+F + + IPE+ + S L +A+ P YEL + N G+ + +
Sbjct: 135 NAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPE 194
Query: 1710 G----LISTQKKLDHEKISSYQLKIRGSNMAGAF----TDVMVVVDIIDENDNAPMFLKS 1761
G + QK+LD E+ +Y +K++ + G F + ++ V + D NDN P+F ++
Sbjct: 195 GDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNHPVFKET 252
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYK---ILEPEALKFFKIDPS 1818
I E AP+ + + +HA+D+D N+ + + ++ A + F ++ +
Sbjct: 253 EIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
G +TI +D E P+ + V D G P A V+++V DVND+ P +
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY-- 359
Query: 1879 VAIVGPIHPGM----------ELLMVRASDEDSEVNYSIKTGNADEA-VTIHPVTGSISV 1927
IV P++ + ++ ++ +D+D++ N + E + PV + +
Sbjct: 360 --IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 1928 LNPA-FLGLS-------RKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
L A +L + L A +A++ I + D + F Q ++ E
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 477
Query: 1980 NLQDRKALVILGAQGNHLNDTLSYFLLNGTDM---FHMVQSAGVLQTRGVAFDREQQDTH 2036
N L + A L G D F + G+L T DRE++D +
Sbjct: 478 NNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGML-TVVKKLDREKEDKY 536
Query: 2037 ELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ +DN P + V VSI D NDN P F H Y + + + ++ TD
Sbjct: 537 LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596
Query: 2097 EDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSE 2156
D G N AVT ++ F ID G I FD + Y V A DGG S S
Sbjct: 597 PDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 2157 EEVLVTV--RNKSNPLFQSP----YYKVRVPENI--TLYTPILHTQARSPEGLRLIYNIV 2208
+V + V N + P+F P Y++ +P T+ ++ + + Y+IV
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL--GSFSEATVEVLVEDVN 2266
LF D +TG +T+ D H V+A D FS V + V +
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESV 776
Query: 2267 DNPPTFSQLV 2276
N ++LV
Sbjct: 777 TNATLINELV 786
Score = 111 bits (278), Expect = 1e-23
Identities = 168/725 (23%), Positives = 283/725 (39%), Gaps = 113/725 (15%)
Query: 127 ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA 186
E+ L ++ I D ND PLF ++I E+ + S A D D+G N Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR--MRKISEGNGFGSLAALVV 244
+F + + T G + EL D M+ E GF
Sbjct: 178 LIKSQNIFGLDV---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQ------ 228
Query: 245 HVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDANSS-GAEVESVEVVGGDPGK 298
R AI V VT D+ND T V + N+ G V + D G+
Sbjct: 229 ------RSSTAILQVSVT--DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 299 HFKAIKSYAR------------SNEFSLVSVKD-INWMEYLHGFNLSLQARSGSGPYFYS 345
+ K S++ + L+++K+ ++ E + L L + G P
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM 340
Query: 346 QIRGFHLPPSKLSSLKFEKAVYRVQ----LSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPS 400
+ + S+ V V LSE P +++ ++ VT + V +
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 401 SENVGFKLN---ARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCN 452
+ F+L + L+ T +D+ Y + + + P S ++ I + D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYL 511
++AP+F +S ++ EN PG + V+A D D G N + Y + GP A P FS+D
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT 519
Query: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
G+++ K +D E + Y F + A D G P V++F+ + + NDN P+F
Sbjct: 520 GMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNF 577
Query: 572 SIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631
+ ++ P ++ ++ D D N + +E + F ++ +GVI RP I+
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDRE 634
Query: 632 QPTSYSLKITASDG----KNYASPTTLNITVVKD--PHFEVPVTCDKTGVLTQFTKTILH 685
+ SY+ + A DG ++ ++ T+N+ V D P F VP
Sbjct: 635 KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP------------------ 676
Query: 686 FIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAG 745
S +Y++ VL S T + ++ A D D G
Sbjct: 677 --------------PSNCSYEL----------------VLPSTNPGTVVFQVIAVDNDTG 706
Query: 746 FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKL 805
N ++ Y I GN F I+ ETG +T+ D + + V DLG P S + +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSV 765
Query: 806 LTVNV 810
+ VN+
Sbjct: 766 VIVNL 770
Score = 61.6 bits (148), Expect = 2e-08
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 32/176 (18%)
Query: 108 NREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
+RE ++SYT ++A + + + +V ++++D ND KP+F P + +P +P
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 167 ---ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ +V A D D G NAE Y+ NTR ++FAI +G +T+ K +VT G H +
Sbjct: 692 GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL 276
V A D L +P ++ SVV+ N+ T AT++
Sbjct: 751 VKAND------------------------LGQPDSLFSVVIVNLFVNESVTNATLI 782
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 248 bits (632), Expect = 1e-64
Identities = 199/664 (29%), Positives = 301/664 (45%), Gaps = 34/664 (5%)
Query: 2763 YQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAI 2822
Y+++V + ++ LV + + D+NDN P+F A + EN + + A+
Sbjct: 108 YEVEV---AILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV 164
Query: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESG----WITTLQELDCETCQTYHFHVVAY 2878
D D G +G +Y L N+ L I++ G + +ELD E TY V
Sbjct: 165 DPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVE 222
Query: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
D G Q SS A++QVS+TD NDN P F E S+ EN+ G V L DADI E
Sbjct: 223 DGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGEN 281
Query: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-ASVTV 2997
+ + + + I+ ++ LDRE T + L V ASDG A V
Sbjct: 282 AKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMV 341
Query: 2998 EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI------LKVSATDLDTDTNAQITYSLH 3051
+ V DVNDN P V++ V I ++ TD D D N ++T
Sbjct: 342 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD 401
Query: 3052 GPGAHE--FKLDPHTGE---LTTLTALDRERKDVFNLVAKATDGGGRSCQ--ADITLHVE 3104
HE F+L P L T LD E + + A D G A + + V+
Sbjct: 402 ----HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
Query: 3105 DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDA 3164
D NDNAP F S V++ +N + + V A D D G NA++ Y L A FS+D
Sbjct: 458 DENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDC 517
Query: 3165 TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS 3224
TG++ + K L + T+ A D G P PL++ TV VS++ D PVF + E++
Sbjct: 518 RTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 3225 VQVPEDAPPGTEVLQLATLTRPG-AEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFET 3283
VPE+ P V L T+T P + + + +E F +D++TG++ N S D E
Sbjct: 577 FYVPENLPRHGTV-GLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 3284 SPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR---VLENALVGDVI 3340
Y ++ S S V +N+ DVN+++P F P + VL + G V+
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVV 695
Query: 3341 LTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
V A D D +N+++ YS++GGN F I + G + + + D + + ++A D
Sbjct: 696 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Query: 3401 SGQP 3404
GQP
Sbjct: 756 LGQP 759
Score = 246 bits (627), Expect = 5e-64
Identities = 208/705 (29%), Positives = 324/705 (45%), Gaps = 38/705 (5%)
Query: 2253 FSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV 2312
F + L+ED+NDN P F V SI E + A D D G N +Y+++
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2313 ED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVN 2368
+ G DV + + ++ +ELD E + + +KV+ D G P + ++ V+
Sbjct: 180 KSQNIFGLDVIETPE-GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2369 VSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL---ILSGNQDR 2425
V+D NDN P F++ + E ++ E A G V ++ A D D + +++ + ++S R
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQH 2484
F +N+++G+I++ + ++ L V ASD G+ A V +N T+ N P
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2485 LY------EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNG-QI 2537
L+EN + TK+ + DKD+ G + +++ + N +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2538 ATLQKLDRENSTERVIAIKVMARDGG----GRVAFCTVKIILTDENDNPPQFKASEYTVS 2593
T LD E++ E AIK++A D G + A +K+ DENDN P F S TVS
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE 2653
I N S + +V A DAD G NA + Y + P+ ++ TG++ V L +
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD--APPEFSLDCRTGMLTVVKKLDREK 532
Query: 2654 NQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIV 2713
F I A+D G P S V V + ++ + + P F+ Y F PE+LP +G++
Sbjct: 533 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592
Query: 2714 KAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ 2773
V D S V + + N D F++D TGVI+ D E + Y V A
Sbjct: 593 -TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 649
Query: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADP----YKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
S V I V DVNDN+PVF P Y+ VL P GT V QV A+D DTG +
Sbjct: 650 RVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMN 708
Query: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQ 2889
+V Y + G N +LFAID E+G IT +++ D + V A D GQ L S
Sbjct: 709 AEVRYSI---VGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSV 765
Query: 2890 ALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
+V + + + NA +E R S P +A + + +D
Sbjct: 766 VIVNLFVNESVTNA-TLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 241 bits (615), Expect = 1e-62
Identities = 198/637 (31%), Positives = 300/637 (47%), Gaps = 43/637 (6%)
Query: 721 SIDVLESVPINTPLARLAATDPDAGFNGKLVY-VIADGNEEGCFDIELETG----LLTVA 775
+I + E+ IN+ AA DPD G NG Y +I N G IE G L V
Sbjct: 145 NISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQ 204
Query: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
LD E + Y++ V V D G PQ+SS +L V+V D NDN P F +++I E+ V
Sbjct: 205 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 264
Query: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYI 890
GT++ +L DAD +N ++ ++ + F L+ TG + + LDRE P +
Sbjct: 265 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 324
Query: 891 LKVEARD---QPSKGHQLFSVTDLIITLEDVNDNSPQCITEH------NRLKVPEDLPPG 941
L V A D P++ L +VT DVNDN P + + + + E++P
Sbjct: 325 LLVLASDGGLMPARAMVLVNVT-------DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV-DLMTGALILERE--LDFERRAGYNLS 998
T + + +D D G R FR+ + + +LE LD+E Y +
Sbjct: 378 TKIALITVTDKDADHNG--RVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
L A+D G+P ++ + + V D N+N P SFV + NSP G Q+ V+A D
Sbjct: 436 LLAADAGKPPLNQS-AMLFIKVKDENDNA-PVFTQSFVTVSIPENNSP-GIQLTKVSAMD 492
Query: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
DSG + ++ Y L FS++ TGM+ + LDRE Y T+LA D G PL+
Sbjct: 493 ADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT 551
Query: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
S V++ + D NDN P + + + E+ P +V + DPD +T +I
Sbjct: 552 SNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILD 611
Query: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
N F I TG++ DRE ++ + V D G S S+++V + ++DVNDN
Sbjct: 612 EN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDN 669
Query: 1239 PPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLV 1296
P+F N L +PG V++++A D D G+N V YSI + + F+ID
Sbjct: 670 KPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQE 729
Query: 1297 TG---VVSSSSTFTAGEYNILTIKATDSGQPPLSASV 1330
TG ++ G + +L +KA D GQP SV
Sbjct: 730 TGNITLMEKCDVTDLGLHRVL-VKANDLGQPDSLFSV 765
Score = 239 bits (609), Expect = 6e-62
Identities = 191/703 (27%), Positives = 323/703 (45%), Gaps = 34/703 (4%)
Query: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH 869
++D NDNAP FP ++I E++ + + D D NG Y L+ F L
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 870 PLTG-------ELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNS 922
+ +L+V LDRE + Y++KV+ D Q S L +++ D NDN
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSVTDTNDNH 246
Query: 923 PQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY----VLMDGAHGTFRVDLMT 978
P + +PE+ P GT +T L A+D D+G ++ + ++ + A F ++ T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 979 GALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ 1038
G + ++ LD E + L + ASDGG AR V V V DVN+N+ V+
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAM---VLVNVTDVNDNVPSIDIRYIVNP 363
Query: 1039 GQ----VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
+ EN P T++ ++ D D+ +G + F + + +++T A
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423
Query: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
LD E Y + +LA D G PL+ ++I+V D NDN P +Q+ SI E+ G
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
+ ++ A D DS K+ + + + F + TG+L+ ++LDRE +D+++ +
Sbjct: 484 QLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
DNG P L S V V I+D NDN P+F+H +N +PE L G V + +D D G
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLP--RHGTVGLITVTDPDYG 600
Query: 1275 LNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYNILT--IKATDSGQPPLSASVRL 1332
N VT SI D +++ F+ID TGV+ + +F + T +KA D G+ S+S ++
Sbjct: 601 DNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 659
Query: 1333 HIEWIPW--PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGL---FWFNISGG 1387
I + +P I + Y + T+P + VI+V+ G+ ++I GG
Sbjct: 660 TINVVDVNDNKPVFI-VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1388 DKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSR--TIATQVHIFMIANINHHR 1445
+ F I++ TG+I + D + + V+ D + ++ + V + + N +
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1446 PQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGS 1488
+ P E+ V + D K L+ + G+
Sbjct: 779 ATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821
Score = 228 bits (580), Expect = 1e-58
Identities = 208/765 (27%), Positives = 336/765 (43%), Gaps = 83/765 (10%)
Query: 425 DRAHYQLHIRTSPGQASTVVVID--IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
+ Y++ + P + +V I I D N++APLF + + ++ EN + A
Sbjct: 104 EHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 163
Query: 483 TDRDHGENGYVTYSIAGPKALPFSID-------PYLGIISTSKPMDYELMKRIYTFRVRA 535
D D G NG Y + + + F +D + + K +D E K Y +V+
Sbjct: 164 VDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDRE-EKDTYVMKVKV 221
Query: 536 SDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQ 595
D G P +R + + + + NDN P+F+E SI ++ PVG S+ + A D D +
Sbjct: 222 EDGGFP-QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 596 NLKY-----EIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNY 648
N K +VS F LN +G+I++K P L + ++ L + ASDG
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP---LDREETPNHKLLVLASDGGLMPA 337
Query: 649 ASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQIN 708
+ +N+T V D ++ + I
Sbjct: 338 RAMVLVNVTDVND---------------------------------------NVPSIDIR 358
Query: 709 HYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELE 768
+ D ++ + E++P+NT +A + TD DA NG++ +
Sbjct: 359 YIVNPVND----TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 769 TGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLT 828
LL AA LDYE+T Y + + D G P + +L + VKD NDNAP F ++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 829 ISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSP--TEKFSLHPLTGELVVTGHLDRESE 886
I E+ G + +++ DADS N ++ Y LL P +FSL TG L V LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 887 PRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF 946
+Y+ + A+D L S + +++ D NDNSP VPE+LP +
Sbjct: 534 DKYLFTILAKDNGVP--PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 947 LDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGR 1006
+ +DPD G V ++D + F +D TG + D E++ Y + A DGGR
Sbjct: 592 ITVTDPDYGDNSAVTLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650
Query: 1007 PLARRTLCHVEVIVLDVNEN----LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSG 1062
++R + V + V+DVN+N + PP S+ V ++ GT V V A D+D+G
Sbjct: 651 -VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSY---ELVLPSTNPGTVVFQVIAVDNDTG 706
Query: 1063 LDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV-PLSSVT 1121
++ E++Y + G F+I+Q+TG I + D + + V A D G L SV
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766
Query: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
V + V ++ N +++ V +APV + D P S
Sbjct: 767 IVNLFVNESVTNATLINELV---RKSTEAPVTPNTEIADVSSPTS 808
Score = 220 bits (561), Expect = 2e-56
Identities = 219/813 (26%), Positives = 365/813 (44%), Gaps = 83/813 (10%)
Query: 872 TGELVVTG-HLDRES-------EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
TGE+ TG +DRE + +VE P ++F + + +ED+NDN+P
Sbjct: 81 TGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAP 137
Query: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM------ 977
+ +PE+ + T A DPD+G G Y L+ + F +D++
Sbjct: 138 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-SQNIFGLDVIETPEGD 196
Query: 978 -TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFV 1036
LI+++ELD E + Y + + DGG P R + ++V V D N+N P F
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDN--HPVFKETE 253
Query: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYF---LRAGTGLAAFSINQDTGMIQTLA 1093
+ + EN+P GT V + A D D G + ++ + L + F +N TG+I
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMS-QAVFYP-----SIQ 1147
PLDRE + L VLA D G +P ++ V + VTD NDN P + + + P +
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG---LLSTAQQLDREN 1204
E+ P+ T + + D D+ G++T ++ F + PV LL TA LD E+
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLETAAYLDYES 428
Query: 1205 KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY 1264
E+ +++ D G+P L ++ + + + D NDN P+F+ V +PE SP +
Sbjct: 429 TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLT 486
Query: 1265 RLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG---VVSSSSTFTAGEYNILTIKATDS 1321
++ A D D G N ++ Y + FS+D TG VV +Y + TI A D+
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKY-LFTILAKDN 545
Query: 1322 GQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRP 1377
G PPL+++V + + I S + F Y+F V E P + VG+I+V G
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1378 GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVH 1434
+I D++ DF I+ TG I D ++ +Y V+ DG SR+ + +V
Sbjct: 603 SAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1435 IFMIANINHHRPQFL----ETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGS 1488
I + ++N ++P F+ YE+ +P T PG + +V A+D D G + + Y+I G
Sbjct: 661 I-NVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1489 QDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR-NFVWVTIHVED 1547
+ LF +D +G + + K D+ + H + V D P + V V + V +
Sbjct: 719 ---NTRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINA 1607
+ +L S + P TE+ V + +D + +L G +
Sbjct: 775 SVTNATLINEL-VRKSTEAPVTPNTEIADVSSPTSD-------YVKILVAAVAGTITVVV 826
Query: 1608 LLGIITLAQKLDQANHAPHTLTVKAEDQGSPQW 1640
++ I + + APH + Q S +W
Sbjct: 827 VIFITAVV----RCRQAPHLKAAQKNKQNS-EW 854
Score = 219 bits (557), Expect = 6e-56
Identities = 192/633 (30%), Positives = 291/633 (45%), Gaps = 58/633 (9%)
Query: 2674 LVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVI-------YSL 2726
LV +R + + P F + S PE+ S+ + AV DP + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAV---DPDVGINGVQNYEL 178
Query: 2727 VRGT---------TPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
++ TPE +K + V+K +D E Y + V
Sbjct: 179 IKSQNIFGLDVIETPEGDK---------MPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 229
Query: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS 2837
S + + V D NDN PVF+ + + EN PVGTSV Q+ A D D G + ++ + S
Sbjct: 230 SSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 289
Query: 2838 ADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSIT 2897
+ LF +++ +G IT + LD E + V+A D G + ++A+V V++T
Sbjct: 290 NLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVT 346
Query: 2898 DENDNAP----RFASEEYRGSVV--ENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
D NDN P R+ +VV EN +A + D D ++ N +VTC+ P
Sbjct: 347 DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD-ADHNGRVTCFTDHEIP 405
Query: 2952 LGQFGISQV-GDEWRISSRKTLDREHTAKYLLRVTASD-GK--FQASVTVEIFVLDVNDN 3007
F + V +++ + + LD E T +Y +++ A+D GK S + I V D NDN
Sbjct: 406 ---FRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN 462
Query: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGEL 3067
+P +Q T + E+ PG + KVSA D D+ NA+I Y L EF LD TG L
Sbjct: 463 APVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGML 522
Query: 3068 TTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDN 3125
T + LDRE++D + A D G +++T+ V D NDN+P F + V +N
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 3126 TTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLEL 3185
V ++ DPD G N+ V S+ D + F+ID+ TGVIR Q
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDEND-DFTIDSQTGVIRPNISFDREKQESYTF 641
Query: 3186 TVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFL----NTEHSVQVPEDAPPGTEVLQLA 3241
V+A D G + S+ VT++VV + D PVF+ N + + +P PGT V Q+
Sbjct: 642 YVKAED-GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVI 699
Query: 3242 TL---TRPGAEKTGYRVVSGNEQGRFRLDARTG 3271
+ T AE Y +V GN + F +D TG
Sbjct: 700 AVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETG 731
Score = 208 bits (530), Expect = 8e-53
Identities = 189/660 (28%), Positives = 296/660 (44%), Gaps = 45/660 (6%)
Query: 2458 DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTID 2517
D +FR V + + N +P F + + EN+ + +K A+D D G G +
Sbjct: 117 DEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 2518 YTIINKLASEKFSI--NPNG----QIATLQKLDRENSTERVIAIKVMARDGG--GRVAFC 2569
Y +I + P G Q+ ++LDRE V+ +KV DGG R +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKV--EDGGFPQRSSTA 233
Query: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN--PE 2627
+++ +TD NDN P FK +E VSI N + V Q+ A DAD G+NA + +S +
Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 2628 DLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKV- 2686
++ + + +N TG++ +K+ L E + A DGG ++V V + V V
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353
Query: 2687 --SLPKFSEPLY-TFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLD 2743
+ P+ T E++P ++I ++ V +D V T + +
Sbjct: 354 SIDIRYIVNPVNDTVVLSENIPLNTKIALI-TVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 2744 PDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYK 2803
+ +++ +D+ESTK Y I ++A + + I+V D NDN PVF
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 2804 AVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQEL 2863
+ EN G + +V+A+D D+G + +++Y L D F++D +G +T +++L
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE----FSLDCRTGMLTVVKKL 528
Query: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
D E Y F ++A D+G L+S V VSI D+NDN+P F EY V EN
Sbjct: 529 DREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLL 2982
V + D D + + + E D F I SQ G I + DRE Y
Sbjct: 588 TVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTG---VIRPNISFDREKQESYTF 641
Query: 2983 RVTASDG---KFQASVTVEIFVLDVNDNSP-------QCSQLLYTGKVHEDVFPGHFILK 3032
V A DG +S V I V+DVNDN P CS L V PG + +
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL----VLPSTNPGTVVFQ 697
Query: 3033 VSATDLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
V A D DT NA++ YS+ G + F +D TG +T + D + ++ KA D G
Sbjct: 698 VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLG 757
Score = 207 bits (528), Expect = 1e-52
Identities = 193/699 (27%), Positives = 309/699 (44%), Gaps = 53/699 (7%)
Query: 2011 MFHMVQSAGVLQTRGVAFDREQ------QDTHELAVEVRDNRTPQRVAQGL-VRVSIEDV 2063
+ + + G + T G DRE+ +D H EV P + + + +R IED+
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEH-CFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 2064 NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRID---- 2119
NDN P F I + + +A D D+G NG YE + F +D
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192
Query: 2120 ---PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE--EVLVTVRNKSNPLFQSP 2174
+ + ++K D + + Y +KV DGG P S +V VT N ++P+F+
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252
Query: 2175 YYKVRVPENITLYTPI--LH-TQARSPEGLRLIY---NIVEEEPLMLFTTDFKTGVLTVT 2228
+V +PEN + T + LH T A E ++ + N+V LF + TG++T+
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 2229 GPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTF------SQLVYTTSIS 2282
PLD E H V A+D L + A V V V DVNDN P+ + + T +S
Sbjct: 313 EPLDREETPNHKLLVLASDGGLMP-ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2283 EGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQ 2342
E +P T + + +D+D+ N V+ D + + + + T LDYE+
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYEST 429
Query: 2343 QHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQ 2402
+ + +K+ A D G PPL ++ + V D NDN P F Q ++ E + G + KV
Sbjct: 430 KEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVS 489
Query: 2403 AIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GV- 2460
A+D DS +++ YL L + F ++ +G++++ + + Y + A D GV
Sbjct: 490 AMDADSGPNAKINYL-LGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 2461 -FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
+ V V+++ + N SP F + Y + EN V + D D G + +
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 2520 IINKLASEKFSI-NPNGQIATLQKLDRENSTERVIAIKVMARDGG--GRVAFCTVKIILT 2576
I+++ ++ F+I + G I DRE +K A DGG R + V I +
Sbjct: 609 ILDE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AEDGGRVSRSSSAKVTINVV 664
Query: 2577 DENDNPPQFKASEYTVSIQSNVSKDSP---VIQVLAYDADEGQNADVTYSV---NPEDLV 2630
D NDN P F S + + +P V QV+A D D G NA+V YS+ N DL
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 2631 KDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
E +T + K + +GL +KA D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHR----VLVKANDLGQP 759
Score = 201 bits (510), Expect = 2e-50
Identities = 181/660 (27%), Positives = 292/660 (44%), Gaps = 38/660 (5%)
Query: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
++ I D NDNAP F + S+ ENS +D D+ Q I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 2952 LGQFGI-SQVGDEW-RISSRKTLDREHTAKYLLRVTASDGKF---QASVTVEIFVLDVND 3006
G I + GD+ ++ +K LDRE Y+++V DG F ++ +++ V D ND
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 244
Query: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS----LHGPGAHEFKLDP 3062
N P + + E+ G + ++ ATD D NA+I +S + F L+
Sbjct: 245 NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNA 304
Query: 3063 HTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAP----RFF--PS 3116
TG +T LDRE L+ A+DGG +A + ++V DVNDN P R+ P
Sbjct: 305 TTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV----YSLPDSAEGHFSIDATTGVIRLE 3172
+ V + +N + T +A++ D D N +V + +P FS LE
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS-----NQFLLE 419
Query: 3173 KPLQVRPQAPLELTVR--ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
+ ++ E ++ A+D G P PL+ + + V D PVF + +V +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 3231 APPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTGILYVNASLDFETSPKYFL 3289
PG ++ +++ + + G + F LD RTG+L V LD E KY
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 3290 SIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDED 3349
+I L+ TV V+I D N++ P F + Y+ V EN + ++ TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 3350 GPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHED 3409
NS +T S++ N FTI + G ++ + DRE+ SY+ ++A D G+
Sbjct: 599 YGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 3410 TDIAIQVADVNDNPPRFF----QLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR 3465
+ I V DVNDN P F +Y + +P G+ V Q+I D D+ N +
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNA-EVRYS 714
Query: 3466 ITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIP-PLSSLTSVRVHVTE 3523
I GN F + + G + E +++ ++A+D G P L S+ V + V E
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 199 bits (506), Expect = 5e-50
Identities = 190/663 (28%), Positives = 292/663 (44%), Gaps = 44/663 (6%)
Query: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
L + ++ D+N+N P F + V + ENS ++ + AA D D G++G Y L
Sbjct: 122 LVKIRFLIEDINDNA--PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 1073 AGT---GLAAFSINQDTGMIQTLAP--LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
GL + M Q + LDRE Y + V D G SS + + V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF---NITSGNYMGF 1184
TD NDN P + SI E+APVGTSV QL A D D K+ F N+ S
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
F ++ TGL++ + LDRE H L V D G + + + V+V + DVNDN P
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDI 357
Query: 1245 KLF------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVT----YSIEDSDEEAFSID 1294
+ V L E + P++ + + +D D NGRVT + I FS
Sbjct: 358 RYIVNPVNDTVVLSENI-PLNT-KIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ 415
Query: 1295 LVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
+ + + EY I + A D+G+PPL+ S L I+ + P+ F +++
Sbjct: 416 FLLETAAYLDYESTKEYAIKLL-AADAGKPPLNQSAMLFIK--VKDENDNAPV-FTQSFV 471
Query: 1355 SFTVMETDPVNHM---VGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTR 1411
+ ++ E + V + + P + G D +F ++ TG + + + LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1412 RRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
+ Y T+ D G + + V +F+ I + N + P F Y VP++ +
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
+ D D G + T+ + F +D +GV+ D S +T V D
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQES-YTFYVKAED 647
Query: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRF----TQLHYEASVPDTIAPGTELLQVRAMDADRG 1585
+ + VTI+V D N + P F + YE +P T PGT + QV A+D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTG 706
Query: 1586 VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
+NAEV YS++ GN+ F I+ G ITL +K D + H + VKA D G P L +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD--SLFS 764
Query: 1646 VII 1648
V+I
Sbjct: 765 VVI 767
Score = 196 bits (498), Expect = 4e-49
Identities = 190/760 (25%), Positives = 332/760 (43%), Gaps = 86/760 (11%)
Query: 1193 LLSTAQQLDREN------KDEHI---LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFS 1243
+ +T ++DRE +DEH +EV +L + + ++ I D+NDN P+F
Sbjct: 84 IFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD---EIFRLVKIRFLIEDINDNAPLFP 140
Query: 1244 HKLFNVRLPERLSPVSPGPVYRLVAS-DLDEGLNGRVTYSIEDSDEEAFSIDLVTG---- 1298
+ N+ +PE + S Y L A+ D D G+NG Y + S + F +D++
Sbjct: 141 ATVINISIPENSAINSK---YTLPAAVDPDVGINGVQNYELIKS-QNIFGLDVIETPEGD 196
Query: 1299 -----VVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETY 1353
+V + ++ +K D G P S++ L + + F ET
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETE 253
Query: 1354 YSFTVMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMD---FDIEKTTGSIVIAR 1406
++ E PV V + G F+ S ++ F + TTG I I
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 1407 PLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV---- 1462
PLD N+ L V +DG A + + + ++N + P ++ RY V DTV
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPS-IDIRYIVNPVNDTVVLSE 372
Query: 1463 -----PGVELLRVQAIDQD-KGKSLIYTIHGSQDPGSASLFQLDP---SSGVLVTVGKLD 1513
+ L+ V D D G+ +T H F+L P + +L T LD
Sbjct: 373 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-------FRLRPVFSNQFLLETAAYLD 425
Query: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
S ++ + ++ D P + I V+D N + P FTQ S+P+ +PG +
Sbjct: 426 YES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
L +V AMDAD G NA+++Y LL ++ F+++ G++T+ +KLD+ + T+ A+
Sbjct: 485 LTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----S 1688
D G P TV + + + ++P+F+ +EY +PE++P + L++ P S
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1689 EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSY--QLKIRGSNMAGAFTDVMVVV 1746
VT + + N D F+++S +G+I D EK SY +K + V +
Sbjct: 604 AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN---PFVIHASDSDKEANSLLVYK 1803
+++D NDN P+F+ + + Y +++ N F + A D+D N+ + Y
Sbjct: 662 NVVDVNDNKPVFI-------VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1804 ILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSP-VLFAPRPAQVIIHV 1862
I+ F ID G +T++ + D + + V +D G P LF+ V+I
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFS-----VVIVN 769
Query: 1863 RDVNDSPPRFS--EQIYEVAIVGPIHPGMELLMVRASDED 1900
VN+S + ++ + P+ P E+ V + D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (448), Expect = 3e-43
Identities = 153/580 (26%), Positives = 250/580 (43%), Gaps = 30/580 (5%)
Query: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
+ R+ Y + V + V + + D+NDN+P + + E+
Sbjct: 100 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 159
Query: 3032 KVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVA 3085
+A D D N Y L G E +L LDRE KD + +
Sbjct: 160 LPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKV 219
Query: 3086 KATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
K DGG RS A + + V D NDN P F + V++ +N V T V + A D D G
Sbjct: 220 KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 279
Query: 3144 ANAQVVYS----LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
NA++ +S + + A F ++ATTG+I +++PL +L V ASD G +
Sbjct: 280 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL---MP 336
Query: 3200 TLGTVTVSVVGLEDYLP------VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGY 3253
V V+V + D +P + +V + E+ P T++ L T+T A+ G
Sbjct: 337 ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIA-LITVTDKDADHNGR 395
Query: 3254 RVVSGNEQGRFRLD---ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVN 3310
+ + FRL + +L A LD+E++ +Y + + + L+ + +
Sbjct: 396 VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 455
Query: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
+ D N++ P F Q + + EN G + VSA D D N+ I Y L+G + F+
Sbjct: 456 VKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFS 514
Query: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
+ + G L V K LDRE+ Y + A D+G PPL + + + + D NDN P F
Sbjct: 515 LDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE 574
Query: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE-GL 3489
Y+ V EN P V + ++DPD +N + ++ + F + ++
Sbjct: 575 YNFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 3490 SRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
R QE Y ++A D G SS V ++V + + P
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Score = 169 bits (429), Expect = 4e-41
Identities = 153/529 (28%), Positives = 241/529 (45%), Gaps = 33/529 (6%)
Query: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHF 3160
+ED+NDNAP F + +++ +N+ + + + A DPD G N Y L S G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 3161 SIDATTG----VIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP 3216
I+ G + ++K L + + V+ D G P ST + VSV D P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSST-AILQVSVTDTNDNHP 247
Query: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYR-----VVSGNEQGRFRLDARTG 3271
VF TE V +PE+AP GT V QL E +VS + F L+A TG
Sbjct: 248 VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG 307
Query: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP----QFPQDPYS 3327
++ + LD E +P + L + S + V+VN+TDVN++ P ++ +P +
Sbjct: 308 LITIKEPLDREETPNHKLLVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVN 365
Query: 3328 TRVL--ENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
V+ EN + I ++ TD+D N +T + + L+ A LD
Sbjct: 366 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3386 REQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKV 3445
E Y++KL A D+G+PPL++ + I+V D NDN P F Q + ++ EN+ G ++
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3446 LQLILSDPDSPENGPPYSFRITKGNNGSA-FRVT-PDGWLVTAEGLSRRAQEWYQLQIQA 3503
++ D DS GP G + F + G L + L R ++ Y I A
Sbjct: 486 TKVSAMDADS---GPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 3504 SDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD- 3562
D+G+PPL+S +V V + +Q+ +P E V E+ + G VG I TD D D
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 3563 -TLTYSLAEEETLGRHFSVGAPDGKI---IAAQGLPRGHYSFNVTVSDG 3607
+T S+ +E F++ + G I I+ + Y+F V DG
Sbjct: 603 SAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648
Score = 166 bits (419), Expect = 6e-40
Identities = 157/630 (24%), Positives = 271/630 (43%), Gaps = 79/630 (12%)
Query: 419 KLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPP 473
K +D ++ Y + ++ G ++ ++ + + D N++ P+F + + ++ EN P
Sbjct: 205 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 264
Query: 474 GTSVLAVTATDRDHGENGYVTYS----IAGPKALPFSIDPYLGIISTSKPMDYELMKRIY 529
GTSV + ATD D GEN + +S ++ F ++ G+I+ +P+D E +
Sbjct: 265 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN-H 323
Query: 530 TFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFE------EVNCTGSIRQDWPVGKSI 583
V ASD G R + + + ++NDN P + VN T + ++ P+ I
Sbjct: 324 KLLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKI 380
Query: 584 MTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITAS 643
++ D D N + + +E+ + FS L+ L Y++K+ A+
Sbjct: 381 ALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY-LDYESTKEYAIKLLAA 439
Query: 644 D-GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702
D GK + + + VKD + PV FT++ +
Sbjct: 440 DAGKPPLNQSAMLFIKVKDENDNAPV----------FTQSFV------------------ 471
Query: 703 STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEG 761
++ + E+ L +++A D D+G N K+ Y++ D E
Sbjct: 472 ------------------TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE- 512
Query: 762 CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFP 821
F ++ TG+LTV LD E + Y+ + D G P +S + V++ D NDN+P F
Sbjct: 513 -FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 571
Query: 822 PGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881
Y + E+ T+ +T D D DN V ++L + F++ TG +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLP-- 939
DRE + Y V+A D S + I + DVNDN P I + LP
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST 689
Query: 940 -PGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNL 997
PGTV+ + A D D G EVRY ++ G F +D TG + L + D + +
Sbjct: 690 NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 998 SLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
+ A+D G+P +L V ++ L VNE++
Sbjct: 750 LVKANDLGQP---DSLFSVVIVNLFVNESV 776
Score = 152 bits (384), Expect = 7e-36
Identities = 138/542 (25%), Positives = 246/542 (45%), Gaps = 40/542 (7%)
Query: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
L+RE +D+Y + ++ + + T ++ V + D ND P+F V+I E+ P+ +
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 166 PICKVTATDADLGQNAEFYYAF-----NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ ++ ATDAD+G+NA+ +++F N +F ++ T+G++T+ L+ H+L
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP-------DSNDGTTYA 273
VLA S+G + A ++V+V P+I + P N
Sbjct: 327 VLA-------SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 274 TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333
L+ A+ D F+ + SN+F L + +++ L
Sbjct: 380 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVF--SNQFLLETAAYLDYESTKEYAIKLL 437
Query: 334 QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA--FP 391
A +G P S + + ++ F ++ V + E + PG ++ V A P
Sbjct: 438 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 392 N--LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVV 444
N + Y+L P + F L+ RTG++T K +D Y I P ++ V
Sbjct: 498 NAKINYLLGPDAP-PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 556
Query: 445 VIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP 504
+ I+D N+++P+F + Y+ + EN+P +V +T TD D+G+N VT SI
Sbjct: 557 FVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND-D 615
Query: 505 FSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMF 564
F+ID G+I + D E + YTF V+A D G R + + + ++NDN+P+F
Sbjct: 616 FTIDSQTGVIRPNISFDRE-KQESYTFYVKAED-GGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 565 --EEVNCTGS-IRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
NC+ + G + + A+D D N ++Y IV GN + F ++ +G I
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI 733
Query: 620 SL 621
+L
Sbjct: 734 TL 735
Score = 144 bits (364), Expect = 1e-33
Identities = 163/670 (24%), Positives = 276/670 (41%), Gaps = 67/670 (10%)
Query: 1656 SAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL-REGNKDGVFSMNSYS 1709
+AP+F + + IPE+ + S L +A+ P YEL + N G+ + +
Sbjct: 135 NAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPE 194
Query: 1710 G----LISTQKKLDHEKISSYQLKIRGSNMAGAF----TDVMVVVDIIDENDNAPMFLKS 1761
G + QK+LD E+ +Y +K++ + G F + ++ V + D NDN P+F ++
Sbjct: 195 GDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQVSVTDTNDNHPVFKET 252
Query: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYK---ILEPEALKFFKIDPS 1818
I E AP+ + + +HA+D+D N+ + + ++ A + F ++ +
Sbjct: 253 EIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYE 1878
G +TI +D E P+ + V D G P A V+++V DVND+ P +
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY-- 359
Query: 1879 VAIVGPIHPGM----------ELLMVRASDEDSEVNYSIKTGNADEA-VTIHPVTGSISV 1927
IV P++ + ++ ++ +D+D++ N + E + PV + +
Sbjct: 360 --IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 1928 LNPA-FLGLS-------RKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
L A +L + L A +A++ I + D + F Q ++ E
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 477
Query: 1980 NLQDRKALVILGAQGNHLNDTLSYFLLNGTDM---FHMVQSAGVLQTRGVAFDREQQDTH 2036
N L + A L G D F + G+L T DRE++D +
Sbjct: 478 NNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGML-TVVKKLDREKEDKY 536
Query: 2037 ELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATD 2096
+ +DN P + V VSI D NDN P F H Y + + + ++ TD
Sbjct: 537 LFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD 596
Query: 2097 EDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSE 2156
D G N AVT ++ F ID G I FD + Y V A DGG S S
Sbjct: 597 PDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 2157 EEVLVTV--RNKSNPLFQSP----YYKVRVPENI--TLYTPILHTQARSPEGLRLIYNIV 2208
+V + V N + P+F P Y++ +P T+ ++ + + Y+IV
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL--GSFSEATVEVLVEDVN 2266
LF D +TG +T+ D H V+A D FS V + V +
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESV 776
Query: 2267 DNPPTFSQLV 2276
N ++LV
Sbjct: 777 TNATLINELV 786
Score = 111 bits (278), Expect = 1e-23
Identities = 168/725 (23%), Positives = 283/725 (39%), Gaps = 113/725 (15%)
Query: 127 ELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYA 186
E+ L ++ I D ND PLF ++I E+ + S A D D+G N Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR--MRKISEGNGFGSLAALVV 244
+F + + T G + EL D M+ E GF
Sbjct: 178 LIKSQNIFGLDV---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQ------ 228
Query: 245 HVEPALRKPPAIASVVVTPPDSNDG-----TTYATVLVDANSS-GAEVESVEVVGGDPGK 298
R AI V VT D+ND T V + N+ G V + D G+
Sbjct: 229 ------RSSTAILQVSVT--DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 299 HFKAIKSYAR------------SNEFSLVSVKD-INWMEYLHGFNLSLQARSGSGPYFYS 345
+ K S++ + L+++K+ ++ E + L L + G P
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM 340
Query: 346 QIRGFHLPPSKLSSLKFEKAVYRVQ----LSEFSPPGSRVVMVRVTPAFPNLQ-YVLKPS 400
+ + S+ V V LSE P +++ ++ VT + V +
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 401 SENVGFKLN---ARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCN 452
+ F+L + L+ T +D+ Y + + + P S ++ I + D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYL 511
++AP+F +S ++ EN PG + V+A D D G N + Y + GP A P FS+D
Sbjct: 461 DNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT 519
Query: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
G+++ K +D E + Y F + A D G P V++F+ + + NDN P+F
Sbjct: 520 GMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNF 577
Query: 572 SIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631
+ ++ P ++ ++ D D N + +E + F ++ +GVI RP I+
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDRE 634
Query: 632 QPTSYSLKITASDG----KNYASPTTLNITVVKD--PHFEVPVTCDKTGVLTQFTKTILH 685
+ SY+ + A DG ++ ++ T+N+ V D P F VP
Sbjct: 635 KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP------------------ 676
Query: 686 FIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAG 745
S +Y++ VL S T + ++ A D D G
Sbjct: 677 --------------PSNCSYEL----------------VLPSTNPGTVVFQVIAVDNDTG 706
Query: 746 FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKL 805
N ++ Y I GN F I+ ETG +T+ D + + V DLG P S + +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSV 765
Query: 806 LTVNV 810
+ VN+
Sbjct: 766 VIVNL 770
Score = 61.6 bits (148), Expect = 2e-08
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 32/176 (18%)
Query: 108 NREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
+RE ++SYT ++A + + + +V ++++D ND KP+F P + +P +P
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 167 ---ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQ 220
+ +V A D D G NAE Y+ NTR ++FAI +G +T+ K +VT G H +
Sbjct: 692 GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Query: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVL 276
V A D L +P ++ SVV+ N+ T AT++
Sbjct: 751 VKAND------------------------LGQPDSLFSVVIVNLFVNESVTNATLI 782
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 173,475,356
Number of Sequences: 37866
Number of extensions: 8426007
Number of successful extensions: 57748
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 18202
Number of HSP's gapped (non-prelim): 6295
length of query: 4349
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4226
effective length of database: 13,590,000
effective search space: 57431340000
effective search space used: 57431340000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.