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Search of human proteins with 68303555
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68303555 aryl hydrocarbon receptor nuclear translocator 2
[Homo sapiens]
(717 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 1451 0.0
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 862 0.0
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 857 0.0
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 439 e-123
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 320 2e-87
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 320 2e-87
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 320 2e-87
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 280 3e-75
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 136 8e-32
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 123 5e-28
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 123 5e-28
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 117 3e-26
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 115 2e-25
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 114 3e-25
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 114 3e-25
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 114 3e-25
gi|21614542 single-minded homolog 1 [Homo sapiens] 113 7e-25
gi|4758010 clock [Homo sapiens] 110 5e-24
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 97 7e-20
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 92 1e-18
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 87 7e-17
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 87 7e-17
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 87 7e-17
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 82 1e-15
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 80 7e-15
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 80 7e-15
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 77 6e-14
gi|12707562 period 2 [Homo sapiens] 72 1e-12
gi|8567388 period 3 [Homo sapiens] 70 7e-12
gi|194097341 period 1 [Homo sapiens] 69 2e-11
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 1451 bits (3757), Expect = 0.0
Identities = 717/717 (100%), Positives = 717/717 (100%)
Query: 1 MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGP 60
MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGP
Sbjct: 1 MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGP 60
Query: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTG 120
SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTG
Sbjct: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTG 120
Query: 121 NKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFG 180
NKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFG
Sbjct: 121 NKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFG 180
Query: 181 STLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICR 240
STLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICR
Sbjct: 181 STLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICR 240
Query: 241 MRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEED 300
MRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEED
Sbjct: 241 MRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEED 300
Query: 301 ADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGY 360
ADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGY
Sbjct: 301 ADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGY 360
Query: 361 QPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTF 420
QPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTF
Sbjct: 361 QPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTF 420
Query: 421 QNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSV 480
QNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSV
Sbjct: 421 QNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSV 480
Query: 481 EKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSS 540
EKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSS
Sbjct: 481 EKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSS 540
Query: 541 VVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGI 600
VVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGI
Sbjct: 541 VVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGI 600
Query: 601 GTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQW 660
GTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQW
Sbjct: 601 GTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQW 660
Query: 661 QSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE 717
QSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE
Sbjct: 661 QSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE 717
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 862 bits (2228), Expect = 0.0
Identities = 470/782 (60%), Positives = 570/782 (72%), Gaps = 89/782 (11%)
Query: 10 PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63
PEM SD+P + P A+G ++ GA+ R KRR G+DFDD DGEG SKF
Sbjct: 8 PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
Query: 64 -------------SRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAV 110
+RENHSEIERRRRNKMT YITELSDMVPTCSALARKPDKLTILRMAV
Sbjct: 62 CDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 121
Query: 111 SHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPV 170
SHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+ ETGRV+YVSDSVTPV
Sbjct: 122 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181
Query: 171 LNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMC 230
LNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKTGTVKKEGQQSSMRMC
Sbjct: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241
Query: 231 MGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWP 290
MGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE + VVHCTGYIKAWP
Sbjct: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301
Query: 291 PAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFV 350
PAG+++P++D + GQGSK+CLVAIGRLQVTSSP C DM+ + PTEF+SRHN +GI TFV
Sbjct: 302 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 361
Query: 351 DPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREW 410
D RC++ +GYQPQ+LLGK+I+EFCHPEDQ LR+SFQQVVKLKGQVLSVM+RFR+KN+EW
Sbjct: 362 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 421
Query: 411 MLIRTSSFTFQNPYSDEIEYIICTNTNVK------------------------------- 439
+ +RTSSFTFQNPYSDEIEYIICTNTNVK
Sbjct: 422 LWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
Query: 440 -----QLQQQQAELE-VHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDP 493
+ QQQQ EL+ V RDGL+SY+ SQV P G E K +EK+D +F+Q+RDP
Sbjct: 482 GQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTG-PEHSKPLEKSDGLFAQDRDP 540
Query: 494 RFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPF-PSGHSGKAFSSSVVHVPGVNDIQS 552
RF+E++ I+A + K +SS++ TQQ++SQG+ F P+ + F +S + P V +Q
Sbjct: 541 RFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGL-APPVTIVQP 599
Query: 553 SSSTGQNMSQISRQLNQSQVA---WT-GSRPPFPGQQIPSQ-SSKTQSSPFGIGTSHTYP 607
S+S GQ ++QISR N +Q A WT +R F QQ+ +Q ++KT++S FG+G+ T
Sbjct: 600 SASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQT-- 657
Query: 608 ADPSSYSPLSSPA--TSSPSGNAYSSLANRTPGFA-ESGQSSGQFQGRPSE---VWSQWQ 661
PSS+S +S P T+SP AY SL NR FA E+GQ++GQFQ R +E VW QWQ
Sbjct: 658 --PSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQ 715
Query: 662 SQ--HHGQQSGEQHSH----QQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPF 715
Q HH S EQH QQPGQ EVFQ+ML M GD + +YN E+F DL MFPPF
Sbjct: 716 GQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQ---SNSYNNEEFPDLTMFPPF 772
Query: 716 SE 717
SE
Sbjct: 773 SE 774
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 857 bits (2213), Expect = 0.0
Identities = 470/797 (58%), Positives = 570/797 (71%), Gaps = 104/797 (13%)
Query: 10 PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63
PEM SD+P + P A+G ++ GA+ R KRR G+DFDD DGEG SKF
Sbjct: 8 PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
Query: 64 ----------------------------SRENHSEIERRRRNKMTQYITELSDMVPTCSA 95
+RENHSEIERRRRNKMT YITELSDMVPTCSA
Sbjct: 62 CDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSA 121
Query: 96 LARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155
LARKPDKLTILRMAVSHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+
Sbjct: 122 LARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSC 181
Query: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215
ETGRV+YVSDSVTPVLNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKT
Sbjct: 182 ETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKT 241
Query: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275
GTVKKEGQQSSMRMCMGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE
Sbjct: 242 GTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEP 301
Query: 276 QYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPT 335
+ VVHCTGYIKAWPPAG+++P++D + GQGSK+CLVAIGRLQVTSSP C DM+ + PT
Sbjct: 302 HFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPT 361
Query: 336 EFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQ 395
EF+SRHN +GI TFVD RC++ +GYQPQ+LLGK+I+EFCHPEDQ LR+SFQQVVKLKGQ
Sbjct: 362 EFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQ 421
Query: 396 VLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVK---------------- 439
VLSVM+RFR+KN+EW+ +RTSSFTFQNPYSDEIEYIICTNTNVK
Sbjct: 422 VLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQR 481
Query: 440 --------------------QLQQQQAELE-VHQRDGLSSYDLSQVPVPNLPAGVHEAGK 478
+ QQQQ EL+ V RDGL+SY+ SQV P G E K
Sbjct: 482 PQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTG-PEHSK 540
Query: 479 SVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPF-PSGHSGKAF 537
+EK+D +F+Q+RDPRF+E++ I+A + K +SS++ TQQ++SQG+ F P+ + F
Sbjct: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
Query: 538 SSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVA---WT-GSRPPFPGQQIPSQ-SSK 592
+S + P V +Q S+S GQ ++QISR N +Q A WT +R F QQ+ +Q ++K
Sbjct: 601 RNSGL-APPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAK 659
Query: 593 TQSSPFGIGTSHTYPADPSSYSPLSSPA--TSSPSGNAYSSLANRTPGFA-ESGQSSGQF 649
T++S FG+G+ T PSS+S +S P T+SP AY SL NR FA E+GQ++GQF
Sbjct: 660 TRTSQFGVGSFQT----PSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQF 715
Query: 650 QGRPSE---VWSQWQSQ--HHGQQSGEQHSH----QQPGQTEVFQDMLPMPGDPTQGTGN 700
Q R +E VW QWQ Q HH S EQH QQPGQ EVFQ+ML M GD + +
Sbjct: 716 QTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQ---SNS 772
Query: 701 YNIEDFADLGMFPPFSE 717
YN E+F DL MFPPFSE
Sbjct: 773 YNNEEFPDLTMFPPFSE 789
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 439 bits (1130), Expect = e-123
Identities = 224/325 (68%), Positives = 257/325 (79%), Gaps = 40/325 (12%)
Query: 10 PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63
PEM SD+P + P A+G ++ GA+ R KRR G+DFDD DGEG SKF
Sbjct: 8 PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
Query: 64 ----------------------------SRENHSEIERRRRNKMTQYITELSDMVPTCSA 95
+RENHSEIERRRRNKMT YITELSDMVPTCSA
Sbjct: 62 CDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSA 121
Query: 96 LARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155
LARKPDKLTILRMAVSHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+
Sbjct: 122 LARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSC 181
Query: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215
ETGRV+YVSDSVTPVLNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKT
Sbjct: 182 ETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKT 241
Query: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275
GTVKKEGQQSSMRMCMGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE
Sbjct: 242 GTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEP 301
Query: 276 QYAVVHCTGYIKAWPPAGMTIPEED 300
+ VVHCTGYIKAWPPAG+++P++D
Sbjct: 302 HFVVVHCTGYIKAWPPAGVSLPDDD 326
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 320 bits (821), Expect = 2e-87
Identities = 196/537 (36%), Positives = 295/537 (54%), Gaps = 42/537 (7%)
Query: 51 DFDDEDG-------EGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKL 103
D DD G +G K +RE HS+IE+RRR+KM +I EL+ +VPTC+A++RK DKL
Sbjct: 10 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 69
Query: 104 TILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163
T+LRMAV HMK++RG N T+ YKP+FL++ ELKHLIL AADGFLFVV + G++++V
Sbjct: 70 TVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFV 129
Query: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEG 222
S+SV +LN Q++ G +L++ +HP D+ K++EQL +S+ + R++D KTG VK +
Sbjct: 130 SESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDI 189
Query: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
R+C G+RRSF CRM+C + + +T K K+ + +H
Sbjct: 190 TPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK---------KKDRKSFCTIHS 240
Query: 283 TGYIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRL--QVTSSPVCMDMNGMSVPTEFLS 339
TGY+K+WPP M + E++ +G CLVAIGRL V PV ++ S+ E++S
Sbjct: 241 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM--EYVS 298
Query: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399
RH DG FVD R +++ Y PQ+LLG E+ H +D HL E +QV++ + ++ +
Sbjct: 299 RHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN 358
Query: 400 MYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV------------KQLQQQQAE 447
Y+F+ K+ ++ +R+ F+F NP++ E+EYI+ TNT V QL
Sbjct: 359 CYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHS 418
Query: 448 LEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEK--ADAIFSQERDPRFAEMFAGISAS 505
++ G + VP +P G + + A+ I R + G S
Sbjct: 419 MDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPL 478
Query: 506 E--KKMMSSASAAGTQQIYSQGSP-FPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQN 559
AS+ G ++I + G+P PS SG S PG SSS G+N
Sbjct: 479 NITSTPPPDASSPGGKKILNGGTPDIPS--SG-LLSGQAQENPGYPYSDSSSILGEN 532
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 320 bits (821), Expect = 2e-87
Identities = 196/537 (36%), Positives = 295/537 (54%), Gaps = 42/537 (7%)
Query: 51 DFDDEDG-------EGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKL 103
D DD G +G K +RE HS+IE+RRR+KM +I EL+ +VPTC+A++RK DKL
Sbjct: 53 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 112
Query: 104 TILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163
T+LRMAV HMK++RG N T+ YKP+FL++ ELKHLIL AADGFLFVV + G++++V
Sbjct: 113 TVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFV 172
Query: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEG 222
S+SV +LN Q++ G +L++ +HP D+ K++EQL +S+ + R++D KTG VK +
Sbjct: 173 SESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDI 232
Query: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
R+C G+RRSF CRM+C + + +T K K+ + +H
Sbjct: 233 TPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK---------KKDRKSFCTIHS 283
Query: 283 TGYIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRL--QVTSSPVCMDMNGMSVPTEFLS 339
TGY+K+WPP M + E++ +G CLVAIGRL V PV ++ S+ E++S
Sbjct: 284 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM--EYVS 341
Query: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399
RH DG FVD R +++ Y PQ+LLG E+ H +D HL E +QV++ + ++ +
Sbjct: 342 RHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN 401
Query: 400 MYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV------------KQLQQQQAE 447
Y+F+ K+ ++ +R+ F+F NP++ E+EYI+ TNT V QL
Sbjct: 402 CYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHS 461
Query: 448 LEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEK--ADAIFSQERDPRFAEMFAGISAS 505
++ G + VP +P G + + A+ I R + G S
Sbjct: 462 MDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPL 521
Query: 506 E--KKMMSSASAAGTQQIYSQGSP-FPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQN 559
AS+ G ++I + G+P PS SG S PG SSS G+N
Sbjct: 522 NITSTPPPDASSPGGKKILNGGTPDIPS--SG-LLSGQAQENPGYPYSDSSSILGEN 575
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 320 bits (821), Expect = 2e-87
Identities = 196/537 (36%), Positives = 295/537 (54%), Gaps = 42/537 (7%)
Query: 51 DFDDEDG-------EGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKL 103
D DD G +G K +RE HS+IE+RRR+KM +I EL+ +VPTC+A++RK DKL
Sbjct: 53 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 112
Query: 104 TILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163
T+LRMAV HMK++RG N T+ YKP+FL++ ELKHLIL AADGFLFVV + G++++V
Sbjct: 113 TVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFV 172
Query: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEG 222
S+SV +LN Q++ G +L++ +HP D+ K++EQL +S+ + R++D KTG VK +
Sbjct: 173 SESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDI 232
Query: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
R+C G+RRSF CRM+C + + +T K K+ + +H
Sbjct: 233 TPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK---------KKDRKSFCTIHS 283
Query: 283 TGYIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRL--QVTSSPVCMDMNGMSVPTEFLS 339
TGY+K+WPP M + E++ +G CLVAIGRL V PV ++ S+ E++S
Sbjct: 284 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM--EYVS 341
Query: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399
RH DG FVD R +++ Y PQ+LLG E+ H +D HL E +QV++ + ++ +
Sbjct: 342 RHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN 401
Query: 400 MYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV------------KQLQQQQAE 447
Y+F+ K+ ++ +R+ F+F NP++ E+EYI+ TNT V QL
Sbjct: 402 CYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHS 461
Query: 448 LEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEK--ADAIFSQERDPRFAEMFAGISAS 505
++ G + VP +P G + + A+ I R + G S
Sbjct: 462 MDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPL 521
Query: 506 E--KKMMSSASAAGTQQIYSQGSP-FPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQN 559
AS+ G ++I + G+P PS SG S PG SSS G+N
Sbjct: 522 NITSTPPPDASSPGGKKILNGGTPDIPS--SG-LLSGQAQENPGYPYSDSSSILGEN 575
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 280 bits (716), Expect = 3e-75
Identities = 152/398 (38%), Positives = 238/398 (59%), Gaps = 24/398 (6%)
Query: 48 SGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILR 107
SG +D + + K RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LR
Sbjct: 92 SGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLR 151
Query: 108 MAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSV 167
MAV H++S++G N Y+PSFL + EL+HLIL+ A+GFLFVV E G++++VS SV
Sbjct: 152 MAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSV 211
Query: 168 TPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEGQQSS 226
+ +LN Q+ G +L++ +HP DV K++EQL + + S +++D KTG V
Sbjct: 212 SKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGR 271
Query: 227 MRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGP--VKEGEAQYAVVHCTG 284
R+ GSRRSF CR++ + + +G P K+ ++ +HCTG
Sbjct: 272 TRVYSGSRRSFFCRIKS-------------CKISVKEEHGCLPNSKKKEHRKFYTIHCTG 318
Query: 285 YIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRLQVTSSPVCMDMNGMSV---PTEFLSR 340
Y+++WPP + + EE S + CLVAIGRLQ P + N + PTEF++R
Sbjct: 319 YLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQ----PYIVPQNSGEINVKPTEFITR 374
Query: 341 HNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVM 400
+G +VD R +++GY PQ+LLG E+ H +D ++L + + V++ K ++L+
Sbjct: 375 FAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDS 434
Query: 401 YRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV 438
Y+FR K+ ++ +++ F+F NP++ E+EYI+ NT V
Sbjct: 435 YKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLV 472
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 136 bits (342), Expect = 8e-32
Identities = 106/407 (26%), Positives = 187/407 (45%), Gaps = 45/407 (11%)
Query: 50 MDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMA 109
M D E S+ +E + R RR+K T+ EL+ +P +++ DK +I+R+A
Sbjct: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
Query: 110 VSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTP 169
+S +++ + + ++ + +Q++ +L L+A +GF+ VV + G +I++S++++
Sbjct: 61 ISFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISK 117
Query: 170 VLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRM 229
+ Q E G ++++ HP D E++RE L S G KK
Sbjct: 118 FMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFG----------KKSKD------ 161
Query: 230 CMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW 289
M + R F RM+C T+ R R V A + V+HCTG +K +
Sbjct: 162 -MSTERDFFMRMKC--------------TVTNRGRT----VNLKSATWKVLHCTGQVKVY 202
Query: 290 PPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITF 349
P ++ G I + P MD+ S FLSRH+ D T+
Sbjct: 203 N----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDS--KTFLSRHSMDMKFTY 256
Query: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409
D R +IGY P++LLG+ EF H D ++ +S Q + KGQV+S YR K+
Sbjct: 257 CDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHGG 315
Query: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGL 456
++ + T NP + + + I+C N + ++++ + Q + L
Sbjct: 316 YVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESL 362
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 123 bits (309), Expect = 5e-28
Identities = 105/405 (25%), Positives = 182/405 (44%), Gaps = 72/405 (17%)
Query: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--SMRG 118
S+ +E + R RR+K ++ EL+ +P ++ DK +++R+ +S+++ +
Sbjct: 15 SERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
Query: 119 TGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
G+ + K ++ L+A DGF+ V+ + G +IY+SD+V + Q E
Sbjct: 75 AGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMGLTQFEL 127
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
G ++++ HP D E++RE L + G VKK +Q++ +RSF
Sbjct: 128 TGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT-------QRSFF 168
Query: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW------PPA 292
RM+C T R R N +K A + V+HCTG+I + P
Sbjct: 169 LRMKC------------TLTSRGRTMN----IKS--ATWKVLHCTGHIHVYDTNSNQPQC 210
Query: 293 GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLSRHNSDGIITF 349
G P CLV I P+ N + +P + FLSRH+ D ++
Sbjct: 211 GYKKPPMT---------CLVLI------CEPIPHPSN-IEIPLDSKTFLSRHSLDMKFSY 254
Query: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409
D R ++GY+P++LLG+ I E+ H D HL ++ + KGQV + YR K
Sbjct: 255 CDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGG 313
Query: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRD 454
++ + T + N + + + I+C N V + Q + Q +
Sbjct: 314 YVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 123 bits (309), Expect = 5e-28
Identities = 105/405 (25%), Positives = 182/405 (44%), Gaps = 72/405 (17%)
Query: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--SMRG 118
S+ +E + R RR+K ++ EL+ +P ++ DK +++R+ +S+++ +
Sbjct: 15 SERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
Query: 119 TGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
G+ + K ++ L+A DGF+ V+ + G +IY+SD+V + Q E
Sbjct: 75 AGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMGLTQFEL 127
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
G ++++ HP D E++RE L + G VKK +Q++ +RSF
Sbjct: 128 TGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT-------QRSFF 168
Query: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW------PPA 292
RM+C T R R N +K A + V+HCTG+I + P
Sbjct: 169 LRMKC------------TLTSRGRTMN----IKS--ATWKVLHCTGHIHVYDTNSNQPQC 210
Query: 293 GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLSRHNSDGIITF 349
G P CLV I P+ N + +P + FLSRH+ D ++
Sbjct: 211 GYKKPPMT---------CLVLI------CEPIPHPSN-IEIPLDSKTFLSRHSLDMKFSY 254
Query: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409
D R ++GY+P++LLG+ I E+ H D HL ++ + KGQV + YR K
Sbjct: 255 CDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGG 313
Query: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRD 454
++ + T + N + + + I+C N V + Q + Q +
Sbjct: 314 YVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 117 bits (294), Expect = 3e-26
Identities = 103/431 (23%), Positives = 187/431 (43%), Gaps = 73/431 (16%)
Query: 53 DDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSH 112
D +D ++ +E + R RR++ T+ + +L+ +P ++ DK +I+R+ +S+
Sbjct: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
Query: 113 MKSMR----------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIY 162
++ R G G + D Y L+A +GF+ V+ AE G + Y
Sbjct: 62 LRMHRLCAAGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTAE-GDMAY 106
Query: 163 VSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEG 222
+S++V+ L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 107 LSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------- 158
Query: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
R F RM+ +T+ R R + A + V++C
Sbjct: 159 -----------ERCFSLRMK--------------STLTSRGRT----LNLKAATWKVLNC 189
Query: 283 TGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHN 342
+G+++A+ P T P D + CLV I + P + FLSRH+
Sbjct: 190 SGHMRAYKPPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHS 244
Query: 343 SDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYR 402
D T+ D R V GY P DL+G E+ H D + +S ++ KGQ ++ YR
Sbjct: 245 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYR 303
Query: 403 FRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EVHQRDGLS 457
F ++ ++ +T + + E I+C + + Q+++ L E H R +
Sbjct: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 363
Query: 458 SYDLSQVPVPN 468
SQ PN
Sbjct: 364 RGAPSQKDTPN 374
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 115 bits (287), Expect = 2e-25
Identities = 101/423 (23%), Positives = 184/423 (43%), Gaps = 73/423 (17%)
Query: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR--- 117
++ +E + R RR++ T+ + +L+ +P ++ DK +I+R+ +S+++ R
Sbjct: 12 TELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA 71
Query: 118 -------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPV 170
G G + D Y L+A +GF+ V+ AE G + Y+S++V+
Sbjct: 72 AGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTAE-GDMAYLSENVSKH 116
Query: 171 LNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMC 230
L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 117 LGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT--------------- 160
Query: 231 MGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWP 290
R F RM+ +T+ R R + A + V++C+G+++A+
Sbjct: 161 ---ERCFSLRMK--------------STLTSRGRT----LNLKAATWKVLNCSGHMRAYK 199
Query: 291 PAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFV 350
P T P D + CLV I + P + FLSRH+ D T+
Sbjct: 200 PPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYC 254
Query: 351 DPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREW 410
D R V GY P DL+G E+ H D + +S ++ KGQ ++ YRF ++ +
Sbjct: 255 DDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGY 313
Query: 411 MLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EVHQRDGLSSYDLSQVP 465
+ +T + + E I+C + + Q+++ L E H R + SQ
Sbjct: 314 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 373
Query: 466 VPN 468
PN
Sbjct: 374 TPN 376
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 114 bits (285), Expect = 3e-25
Identities = 112/415 (26%), Positives = 181/415 (43%), Gaps = 56/415 (13%)
Query: 54 DEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHM 113
DED + +K + N SE ++RR++ I ELS M+P RK DK T+L + +
Sbjct: 2 DEDEKDRAKRASRNKSE--KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFL 56
Query: 114 KSMRGTGNKST----DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTP 169
+ ++ +KPSFL+ +E L+LEA DGF+ V + G +IYVSDS+TP
Sbjct: 57 QKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITP 115
Query: 170 VLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILD---LKTGTVKKEGQQSS 226
+L S+ L + L EQ E+S +IL L T + E +S
Sbjct: 116 LLGHLPSDVMDQNL--------LNFLPEQ----EHSEVYKILSSHMLVTDSPSPEYLKSD 163
Query: 227 MRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYI 286
S F C + G+ P FR+ C G+
Sbjct: 164 ------SDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRS--------YNNVPSPSCNGFD 209
Query: 287 KAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVP-TEFLSRHNSDG 345
V G + C +A RL + +M + P EF SRH+ +
Sbjct: 210 NTL--------SRPCRVPLGKEVCFIATVRL--ATPQFLKEMCIVDEPLEEFTSRHSLEW 259
Query: 346 IITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRT 405
F+D R +IGY P ++LG ++ H +D L Q +++ G+ S YRF T
Sbjct: 260 KFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLT 318
Query: 406 KNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYD 460
K ++W+ ++T + + ++ + E+I+CT++ V A++ V +R L+ D
Sbjct: 319 KGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVV-----SYADVRVERRQELALED 368
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 114 bits (285), Expect = 3e-25
Identities = 103/403 (25%), Positives = 183/403 (45%), Gaps = 57/403 (14%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKST 124
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K MR +
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRAVFPEGL 60
Query: 125 DGAY-KPSFL-----TEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
A+ +PS +EL +L+ DGF+FVVA++ G+++Y+S++ + L Q E
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
G+++YE +HP D +++ L T+ + +L Q+ + RSF
Sbjct: 120 TGNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEIE------RSFF 161
Query: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPE 298
RM+C A + G G Y V+HC+GY+K I +
Sbjct: 162 LRMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK--------IRQ 193
Query: 299 EDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE-FLSRHNSDGIITFVDPRCISV 357
D+ C +G + V S + + + + F+ R + D + F+D R V
Sbjct: 194 YMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 358 IGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSS 417
GY+PQDL+ K + H D HLR + ++ +KGQV + YR +K W+ +++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 418 FTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYD 460
N S I+ N + +++ ++ +L + Q S D
Sbjct: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQD 354
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 114 bits (285), Expect = 3e-25
Identities = 103/403 (25%), Positives = 183/403 (45%), Gaps = 57/403 (14%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKST 124
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K MR +
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRAVFPEGL 60
Query: 125 DGAY-KPSFL-----TEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
A+ +PS +EL +L+ DGF+FVVA++ G+++Y+S++ + L Q E
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
G+++YE +HP D +++ L T+ + +L Q+ + RSF
Sbjct: 120 TGNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEIE------RSFF 161
Query: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPE 298
RM+C A + G G Y V+HC+GY+K I +
Sbjct: 162 LRMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK--------IRQ 193
Query: 299 EDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE-FLSRHNSDGIITFVDPRCISV 357
D+ C +G + V S + + + + F+ R + D + F+D R V
Sbjct: 194 YMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 358 IGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSS 417
GY+PQDL+ K + H D HLR + ++ +KGQV + YR +K W+ +++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 418 FTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYD 460
N S I+ N + +++ ++ +L + Q S D
Sbjct: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQD 354
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 113 bits (282), Expect = 7e-25
Identities = 100/394 (25%), Positives = 173/394 (43%), Gaps = 55/394 (13%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKST 124
+E R RR K EL+ ++P SA+ + DK +I+R+ S++K MR +
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRVVFPEGL 60
Query: 125 DGAYKPSFLTE------QELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
A+ S T +EL +L+ DGF+FVVA + G+++Y+S++ + L Q E
Sbjct: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVEL 119
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
G+++YE +HP D +++ L + + + + + RSF
Sbjct: 120 TGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFF 161
Query: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPE 298
RM+C A + G G Y V+HC+GY+K + P
Sbjct: 162 LRMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKIRQYSLDMSPF 201
Query: 299 EDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVI 358
+ G LVA+G S+ + ++ F+ R + D + F+D R +
Sbjct: 202 DGCYQNVG----LVAVGHSLPPSAVTEIKLHS----NMFMFRASLDMKLIFLDSRVAELT 253
Query: 359 GYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSF 418
GY+PQDL+ K + H D HLR ++ +KGQV + YRF K+ W+ +++ +
Sbjct: 254 GYEPQDLIEKTLYHHVHGCDTFHLR-CAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYAT 312
Query: 419 TFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQ 452
N S I+ N + + + +L + Q
Sbjct: 313 IVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 110 bits (275), Expect = 5e-24
Identities = 131/552 (23%), Positives = 228/552 (41%), Gaps = 71/552 (12%)
Query: 53 DDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSH 112
DD+D K R + ++ E++RR++ I EL M+P ARK DK T+L+ ++
Sbjct: 29 DDKD-----KAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDF 80
Query: 113 MKSMRGTGNKSTDGA----YKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVT 168
++ + +S +KP+FL+ +E L+LEA DGF + + G +IYVS+SVT
Sbjct: 81 LRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GSIIYVSESVT 139
Query: 169 PVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCT---SENSMTGRILDLKTGTVKKEGQQS 225
+L S+ +++ + + ++ + L T +S+T L K
Sbjct: 140 SLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSK----------- 188
Query: 226 SMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGY 285
++ F C M G P T +F +G K + + H G+
Sbjct: 189 -------NQLEFCCHMLRGTID----PKEPSTYEYVKF---IGNFKSLNSVSSSAH-NGF 233
Query: 286 IKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE-FLSRHNSD 344
E+ + C VA RL + +M + P E F SRH+ +
Sbjct: 234 EGTIQRTHRPSYED--------RVCFVATVRL--ATPQFIKEMCTVEEPNEEFTSRHSLE 283
Query: 345 GIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFR 404
F+D R +IGY P ++LG ++ H +D +L + + +++ G+ S YRF
Sbjct: 284 WKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQY-GKGKSCYYRFL 342
Query: 405 TKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQV 464
TK ++W+ ++T + + ++ E+I+CT+T V AE+ +R L +
Sbjct: 343 TKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVV-----SYAEVRAERRRELG----IEE 393
Query: 465 PVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQ 524
+P A + S + + + +E RF ++S SS +A S
Sbjct: 394 SLPETAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPS--ST 451
Query: 525 GSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQ 584
+ P+ S H V S SS N + L Q ++ + P
Sbjct: 452 PTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSLTQPVMSQATNLP----- 506
Query: 585 QIPSQSSKTQSS 596
IP S+ Q S
Sbjct: 507 -IPQGMSQFQFS 517
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 96.7 bits (239), Expect = 7e-20
Identities = 91/378 (24%), Positives = 160/378 (42%), Gaps = 73/378 (19%)
Query: 106 LRMAVSHMKSMR----------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155
+R+ +S+++ R G G + D Y L+A +GF+ V+ A
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTA 46
Query: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215
E G + Y+S++V+ L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 47 E-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT 104
Query: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275
R F RM+ +T+ R R + A
Sbjct: 105 ------------------ERCFSLRMK--------------STLTSRGRT----LNLKAA 128
Query: 276 QYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPT 335
+ V++C+G+++A+ P T P D + CLV I + P +
Sbjct: 129 TWKVLNCSGHMRAYKPPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRG 183
Query: 336 EFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQ 395
FLSRH+ D T+ D R V GY P DL+G E+ H D + +S ++ KGQ
Sbjct: 184 AFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQ 242
Query: 396 VLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EV 450
++ YRF ++ ++ +T + + E I+C + + Q+++ L E
Sbjct: 243 AVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQ 302
Query: 451 HQRDGLSSYDLSQVPVPN 468
H R + SQ PN
Sbjct: 303 HSRRPIQRGAPSQKDTPN 320
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 92.4 bits (228), Expect = 1e-18
Identities = 105/427 (24%), Positives = 186/427 (43%), Gaps = 73/427 (17%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
Query: 115 --SMRGTG---NKSTDGAYK---PSFLT----EQELKHLILEAADGFLFVVAAETGRVIY 162
++R G N S GA + PS L E L IL++ DGF+F + E G+ +Y
Sbjct: 83 PWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQE-GKFLY 141
Query: 163 VSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLC-------------TSENSMTGR 209
+S++V+ L Q E GS++++ VHP D ++ EQL T+E+ +
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
Query: 210 ILDLKTGTVKKEGQQSSMRMCMGS--RRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267
++ T + S + + RSF RM+ +T+ KR
Sbjct: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMK--------------STLTKR----- 242
Query: 268 GPVKEGEAQYAVVHCTGYIKAWPPA--GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVC 325
V + Y V+H TG ++ G T+P + + +VA T + V
Sbjct: 243 -GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGL------VVVAHALPPPTINEVR 295
Query: 326 MDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRES 385
+D + F++R N D I + + R + P D++GK F H ED +R S
Sbjct: 296 IDCH------MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHS 349
Query: 386 FQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQ 445
++ KGQ ++ YR+ KN ++ I++S+ N + + II N + + +
Sbjct: 350 HLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKD 408
Query: 446 AELEVHQ 452
+++ Q
Sbjct: 409 TPMDIAQ 415
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 86.7 bits (213), Expect = 7e-17
Identities = 155/650 (23%), Positives = 250/650 (38%), Gaps = 125/650 (19%)
Query: 48 SGMDFDDEDGEGPSKFSRENH------SEIERRRRNKMTQYITELSDM----VPTCSALA 97
SG+ D P R+ S E+RRR + +Y+ EL+++ + +L+
Sbjct: 2 SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS 61
Query: 98 RKPDKLTILRMAVSH---MKSMRGTGNKSTDGAYKPSF-------LTEQELKHLILEAAD 147
KPDK IL+ V MK M + + D K + ++ L L+LEA D
Sbjct: 62 VKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALD 121
Query: 148 GFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMT 207
GF FVV E GR+++VS++VT L Q E +++Y +H D + + L
Sbjct: 122 GFFFVVNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK----- 175
Query: 208 GRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267
L G Q+++ R + +F CRM L H P T
Sbjct: 176 ----SLVNGV--PWPQEATRR----NSHTFNCRM------LIHPPDEPGTEN-------- 211
Query: 268 GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMD 327
+E +Y V+ C ++ P+ + G+ + CL+ I R ++ P
Sbjct: 212 ---QEACQRYEVMQC---------FTVSQPKSIQEDGEDFQSCLICIAR-RLPRPPAITG 258
Query: 328 MNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQP-QDLLGKDILEFCHPE--DQSHLRE 384
+ F+++ ++ G I +D + G +DL+ K I F P+ + S+ R+
Sbjct: 259 VE------SFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQ 312
Query: 385 SFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQ 444
FQ+V+ +G S YRF N ML + P S +++ I
Sbjct: 313 LFQEVM-TRGTASSPSYRF-ILNDGTMLSAHTKCKLCYPQSPDMQPFI-----------M 359
Query: 445 QAELEVHQRDGLSSYD--LSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGI 502
+ + GLS D S + +P + V+ S+ A + P
Sbjct: 360 GIHIIDREHSGLSPQDDTNSGMSIPRVNPSVN---PSISPAHGVARSSTLPPSNSNMVST 416
Query: 503 SASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQ 562
+ ++ S++ + SQGS G + S +V +N Q+SS + S
Sbjct: 417 RINRQQSSDLHSSSHSNSSNSQGS------FGCSPGSQIVANVALNQGQASSQS----SN 466
Query: 563 ISRQLNQSQVAWTG------------------SRPPFPGQQIPSQSSKTQSSPFGIGTSH 604
S LN S + TG +RP P P S T SSP G+ TS
Sbjct: 467 PSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNIS-TLSSPVGM-TSS 524
Query: 605 TYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPS 654
+ SYS + P TS N N + GF+ S Q + S
Sbjct: 525 ACNNNNRSYSNI--PVTSLQGMN---EGPNNSVGFSASSPVLRQMSSQNS 569
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 86.7 bits (213), Expect = 7e-17
Identities = 155/650 (23%), Positives = 250/650 (38%), Gaps = 125/650 (19%)
Query: 48 SGMDFDDEDGEGPSKFSRENH------SEIERRRRNKMTQYITELSDM----VPTCSALA 97
SG+ D P R+ S E+RRR + +Y+ EL+++ + +L+
Sbjct: 2 SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS 61
Query: 98 RKPDKLTILRMAVSH---MKSMRGTGNKSTDGAYKPSF-------LTEQELKHLILEAAD 147
KPDK IL+ V MK M + + D K + ++ L L+LEA D
Sbjct: 62 VKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALD 121
Query: 148 GFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMT 207
GF FVV E GR+++VS++VT L Q E +++Y +H D + + L
Sbjct: 122 GFFFVVNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK----- 175
Query: 208 GRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267
L G Q+++ R + +F CRM L H P T
Sbjct: 176 ----SLVNGV--PWPQEATRR----NSHTFNCRM------LIHPPDEPGTEN-------- 211
Query: 268 GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMD 327
+E +Y V+ C ++ P+ + G+ + CL+ I R ++ P
Sbjct: 212 ---QEACQRYEVMQC---------FTVSQPKSIQEDGEDFQSCLICIAR-RLPRPPAITG 258
Query: 328 MNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQP-QDLLGKDILEFCHPE--DQSHLRE 384
+ F+++ ++ G I +D + G +DL+ K I F P+ + S+ R+
Sbjct: 259 VE------SFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQ 312
Query: 385 SFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQ 444
FQ+V+ +G S YRF N ML + P S +++ I
Sbjct: 313 LFQEVM-TRGTASSPSYRF-ILNDGTMLSAHTKCKLCYPQSPDMQPFI-----------M 359
Query: 445 QAELEVHQRDGLSSYD--LSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGI 502
+ + GLS D S + +P + V+ S+ A + P
Sbjct: 360 GIHIIDREHSGLSPQDDTNSGMSIPRVNPSVN---PSISPAHGVARSSTLPPSNSNMVST 416
Query: 503 SASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQ 562
+ ++ S++ + SQGS G + S +V +N Q+SS + S
Sbjct: 417 RINRQQSSDLHSSSHSNSSNSQGS------FGCSPGSQIVANVALNQGQASSQS----SN 466
Query: 563 ISRQLNQSQVAWTG------------------SRPPFPGQQIPSQSSKTQSSPFGIGTSH 604
S LN S + TG +RP P P S T SSP G+ TS
Sbjct: 467 PSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNIS-TLSSPVGM-TSS 524
Query: 605 TYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPS 654
+ SYS + P TS N N + GF+ S Q + S
Sbjct: 525 ACNNNNRSYSNI--PVTSLQGMN---EGPNNSVGFSASSPVLRQMSSQNS 569
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 86.7 bits (213), Expect = 7e-17
Identities = 155/650 (23%), Positives = 250/650 (38%), Gaps = 125/650 (19%)
Query: 48 SGMDFDDEDGEGPSKFSRENH------SEIERRRRNKMTQYITELSDM----VPTCSALA 97
SG+ D P R+ S E+RRR + +Y+ EL+++ + +L+
Sbjct: 2 SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS 61
Query: 98 RKPDKLTILRMAVSH---MKSMRGTGNKSTDGAYKPSF-------LTEQELKHLILEAAD 147
KPDK IL+ V MK M + + D K + ++ L L+LEA D
Sbjct: 62 VKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALD 121
Query: 148 GFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMT 207
GF FVV E GR+++VS++VT L Q E +++Y +H D + + L
Sbjct: 122 GFFFVVNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK----- 175
Query: 208 GRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267
L G Q+++ R + +F CRM L H P T
Sbjct: 176 ----SLVNGV--PWPQEATRR----NSHTFNCRM------LIHPPDEPGTEN-------- 211
Query: 268 GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMD 327
+E +Y V+ C ++ P+ + G+ + CL+ I R ++ P
Sbjct: 212 ---QEACQRYEVMQC---------FTVSQPKSIQEDGEDFQSCLICIAR-RLPRPPAITG 258
Query: 328 MNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQP-QDLLGKDILEFCHPE--DQSHLRE 384
+ F+++ ++ G I +D + G +DL+ K I F P+ + S+ R+
Sbjct: 259 VE------SFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQ 312
Query: 385 SFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQ 444
FQ+V+ +G S YRF N ML + P S +++ I
Sbjct: 313 LFQEVM-TRGTASSPSYRF-ILNDGTMLSAHTKCKLCYPQSPDMQPFI-----------M 359
Query: 445 QAELEVHQRDGLSSYD--LSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGI 502
+ + GLS D S + +P + V+ S+ A + P
Sbjct: 360 GIHIIDREHSGLSPQDDTNSGMSIPRVNPSVN---PSISPAHGVARSSTLPPSNSNMVST 416
Query: 503 SASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQ 562
+ ++ S++ + SQGS G + S +V +N Q+SS + S
Sbjct: 417 RINRQQSSDLHSSSHSNSSNSQGS------FGCSPGSQIVANVALNQGQASSQS----SN 466
Query: 563 ISRQLNQSQVAWTG------------------SRPPFPGQQIPSQSSKTQSSPFGIGTSH 604
S LN S + TG +RP P P S T SSP G+ TS
Sbjct: 467 PSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNIS-TLSSPVGM-TSS 524
Query: 605 TYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPS 654
+ SYS + P TS N N + GF+ S Q + S
Sbjct: 525 ACNNNNRSYSNI--PVTSLQGMN---EGPNNSVGFSASSPVLRQMSSQNS 569
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 82.4 bits (202), Expect = 1e-15
Identities = 104/446 (23%), Positives = 184/446 (41%), Gaps = 92/446 (20%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
Query: 115 --SMRGTG---NKSTDGAY----------------------KPSFLT----EQELKHLIL 143
++R G N S G PS L E L IL
Sbjct: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
Query: 144 EAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLC--- 200
++ DGF+F + E G+ +Y+S++V+ L Q E GS++++ VHP D ++ EQL
Sbjct: 143 QSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
Query: 201 ----------TSENSMTGRILDLKTGTVKKEGQQSSMRMCMGS--RRSFICRMRCGNAPL 248
T+E+ + ++ T + S + + RSF RM+
Sbjct: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMK------ 255
Query: 249 DHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPA--GMTIPEEDADVGQG 306
+T+ KR V + Y V+H TG ++ G T+P + +
Sbjct: 256 --------STLTKR------GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGL--- 298
Query: 307 SKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLL 366
+VA T + V +D + F++R N D I + + R + P D++
Sbjct: 299 ---VVVAHALPPPTINEVRIDCH------MFVTRVNMDLNIIYCENRISDYMDLTPVDIV 349
Query: 367 GKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSD 426
GK F H ED +R S ++ KGQ ++ YR+ KN ++ I++S+ N +
Sbjct: 350 GKRCYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNA 408
Query: 427 EIEYIICTNTNVKQLQQQQAELEVHQ 452
+ II N + + + +++ Q
Sbjct: 409 NEKNIIWVNYLLSNPEYKDTPMDIAQ 434
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 80.1 bits (196), Expect = 7e-15
Identities = 87/380 (22%), Positives = 167/380 (43%), Gaps = 62/380 (16%)
Query: 72 ERRRRNKMTQYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSMRGTGN------ 121
E+RRR + ++YI EL++++ KPDK IL+ V ++ ++ G
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 122 ---KSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
K+ + + + L L+L+A DGFLFVV + G +++VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
+++Y +H +D + + L ++++ G + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNL--PKSTVNG-----VSWTNETQRQKS---------HTFN 196
Query: 239 CRMRCGNAPLDHL-PLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIP 297
CRM P D L +N MR+R Y + C ++ P
Sbjct: 197 CRMLM-KTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 298 EEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCI-S 356
+ G+ + C++ + R ++T+ N P F++RH+ G + +D + S
Sbjct: 233 RAMMEEGEDLQSCMICVAR-RITTGERTFPSN----PESFITRHDLSGKVVNIDTNSLRS 287
Query: 357 VIGYQPQDLLGKDILEFCHPED-QSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRT 415
+ +D++ + I F D QS ++ Q L G + +YRF + + +T
Sbjct: 288 SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQT 347
Query: 416 SSFTFQNPYSDEIEYIICTN 435
S F+NP +++ + T+
Sbjct: 348 KSKLFRNPVTNDRHGFVSTH 367
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 80.1 bits (196), Expect = 7e-15
Identities = 87/380 (22%), Positives = 167/380 (43%), Gaps = 62/380 (16%)
Query: 72 ERRRRNKMTQYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSMRGTGN------ 121
E+RRR + ++YI EL++++ KPDK IL+ V ++ ++ G
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 122 ---KSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
K+ + + + L L+L+A DGFLFVV + G +++VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
+++Y +H +D + + L ++++ G + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNL--PKSTVNG-----VSWTNETQRQKS---------HTFN 196
Query: 239 CRMRCGNAPLDHL-PLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIP 297
CRM P D L +N MR+R Y + C ++ P
Sbjct: 197 CRMLM-KTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 298 EEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCI-S 356
+ G+ + C++ + R ++T+ N P F++RH+ G + +D + S
Sbjct: 233 RAMMEEGEDLQSCMICVAR-RITTGERTFPSN----PESFITRHDLSGKVVNIDTNSLRS 287
Query: 357 VIGYQPQDLLGKDILEFCHPED-QSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRT 415
+ +D++ + I F D QS ++ Q L G + +YRF + + +T
Sbjct: 288 SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQT 347
Query: 416 SSFTFQNPYSDEIEYIICTN 435
S F+NP +++ + T+
Sbjct: 348 KSKLFRNPVTNDRHGFVSTH 367
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 77.0 bits (188), Expect = 6e-14
Identities = 95/436 (21%), Positives = 185/436 (42%), Gaps = 81/436 (18%)
Query: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
Query: 115 --SMRGTGNKS--TDGAYKPSFLT----EQELKHLILEAADGFLFVVAAETGRVIYVSDS 166
+R G + G P+ L EQ L IL++ DGF+F + E G+ +Y+S++
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
Query: 167 VTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQL--------------CTSENSMTGRILD 212
V+ L Q E GS++++ +HP D ++ EQL +S +S + + D
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 213 LKTGTVKKEGQQSSM-RMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVK 271
T + E + + + RSF RM+ +T+ KR GL
Sbjct: 226 ----TPEIEASLTKVPPSSLVQERSFFVRMK--------------STLTKR---GLHVKA 264
Query: 272 EGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGM 331
G Y V+H TG ++A LVA+G + + ++G
Sbjct: 265 SG---YKVIHVTGRLRA------------------HALGLVALGHTLPPAPLAELPLHGH 303
Query: 332 SVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVK 391
+ + R + I + R + P +L+G+ +F H +D + +R+S ++
Sbjct: 304 MI----VFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD 359
Query: 392 LKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVH 451
KGQV++ YR+ + ++ +++ + + S +++ + + Q + Q L+
Sbjct: 360 -KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAF 418
Query: 452 QRDGLSSYDLSQVPVP 467
Q + + + P P
Sbjct: 419 QLPASVACEEASSPGP 434
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 72.4 bits (176), Expect = 1e-12
Identities = 83/394 (21%), Positives = 152/394 (38%), Gaps = 69/394 (17%)
Query: 55 EDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK 114
E S S + S+++ + ++ + + EL +P K L L+ A+ +K
Sbjct: 89 EHNPSTSGCSSDQSSKVDTHK--ELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVK 146
Query: 115 SMRG---------TGNKSTDGAYKPSFLTEQE---LKHLILEAADGFLFVVAAETGRVIY 162
++ + GA PS+ E+ I++ AD F V+ +G+++Y
Sbjct: 147 QVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILY 206
Query: 163 VSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEG 222
+SD V + + + + + E + P DV + + G
Sbjct: 207 ISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMC----------SG 256
Query: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
S + CM +SF CR+ ++RK N E +Y
Sbjct: 257 ADSFTQECM-EEKSFFCRV----------------SVRKSHEN--------EIRYHPFRM 291
Query: 283 TGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLS 339
T Y+ + D + CL+ R+ +P E F +
Sbjct: 292 TPYL---------VKVRDQQGAESQLCCLLLAERVH-------SGYEAPRIPPEKRIFTT 335
Query: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399
H + + VD R + ++GY PQDL+ +L HP D+ + +++++ GQ
Sbjct: 336 THTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDY 395
Query: 400 M-YRFRTKNREWMLIRTSSFTFQNPYSDEIEYII 432
RFR +N E++ + TS +F NP+S +I +II
Sbjct: 396 SPIRFRARNGEYITLDTSWSSFINPWSRKISFII 429
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 70.1 bits (170), Expect = 7e-12
Identities = 94/424 (22%), Positives = 161/424 (37%), Gaps = 84/424 (19%)
Query: 37 GAMPARGGKRRSGMDFDDEDGEGPS-------KFSRENHSEIERRRR--NKMTQYITELS 87
G P G + +E GE S K + +HSE + R R ++ + E+
Sbjct: 4 GEAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMK 63
Query: 88 DMVPTCSALARKPDKLTILRMAVSHMKSMRGTGN----KSTDGAYKP--SFLTEQELKHL 141
P S KP L L A+ + S++ S +GA + S + +EL +
Sbjct: 64 KYFP--SERRNKPSTLDALNYALRCVHSVQANSEFFQILSQNGAPQADVSMYSLEELATI 121
Query: 142 ILEAA----DGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLRE 197
E D F+ V + +GR++++S+ +LN+ + S + + P D+
Sbjct: 122 ASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYA 181
Query: 198 QLCTSE----NSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLD---H 250
++ N+ T R + VK F CR+R G H
Sbjct: 182 HTARAQLPFWNNWTQRAARYECAPVKP----------------FFCRIRGGEDRKQEKCH 225
Query: 251 LPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYC 310
P I + I PA + E C
Sbjct: 226 SPFRIIPYL--------------------------IHVHHPAQPELESEPC--------C 251
Query: 311 LVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDI 370
L + ++ + +N F + H + VD + + ++GY PQDL+G I
Sbjct: 252 LTVVEKIHSGYEAPRIPVNKRI----FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSI 307
Query: 371 LEFCHPEDQSHLRESFQQVVKLKGQ--VLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEI 428
L + HPED+S + Q+V+K G RF T+N +++++ +S +F NP+S +I
Sbjct: 308 LSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWSSFVNPWSRKI 367
Query: 429 EYII 432
+II
Sbjct: 368 SFII 371
>gi|194097341 period 1 [Homo sapiens]
Length = 1290
Score = 68.9 bits (167), Expect = 2e-11
Identities = 71/310 (22%), Positives = 121/310 (39%), Gaps = 59/310 (19%)
Query: 131 SFLTEQELKHLI----LEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQ 186
S T +EL+H+ L+ D F V+ TGR++Y+S+ +L + + G+ E
Sbjct: 198 STYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSEL 257
Query: 187 VHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNA 246
+ P DV S G TG G + + +S CR+R G
Sbjct: 258 LAPQDVGVFYGSTAPSRLPTWG------TGASAGSGLRDFTQ-----EKSVFCRIRGG-- 304
Query: 247 PLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQG 306
P ++ +Y T Y+ +D
Sbjct: 305 ----------------------PDRDPGPRYQPFRLTPYVTKI---------RVSDGAPA 333
Query: 307 SKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLSRHNSDGIITFVDPRCISVIGYQPQ 363
CL+ R+ +P + F +RH + VD R ++GY PQ
Sbjct: 334 QPCCLLIAERIH-------SGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYLPQ 386
Query: 364 DLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLS-VMYRFRTKNREWMLIRTSSFTFQN 422
DLLG +L F HPED+ + +++++L GQ RF +N E++ + TS F +
Sbjct: 387 DLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVH 446
Query: 423 PYSDEIEYII 432
P+S ++ +++
Sbjct: 447 PWSRKVAFVL 456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,517,456
Number of Sequences: 37866
Number of extensions: 1529653
Number of successful extensions: 5792
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 4933
Number of HSP's gapped (non-prelim): 796
length of query: 717
length of database: 18,247,518
effective HSP length: 110
effective length of query: 607
effective length of database: 14,082,258
effective search space: 8547930606
effective search space used: 8547930606
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.