Guide to the Human Genome
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Name: HIF1A Sequence: fasta or formatted (826aa) NCBI GI: 4504385
Description:

hypoxia-inducible factor 1, alpha subunit isoform 1

Referenced in:

Oxygen Sensing and Hemoglobin

Other entries for this name:
alt prot [735aa] hypoxia-inducible factor 1, alpha subunit isoform 2
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.2         43           2
 C cysteine            1.8         15           1
 D aspartate           6.9         57           3
 E glutamate           7.4         61           3
 F phenylalanine       2.9         24           2
 G glycine             4.1         34           2
 H histidine           2.7         22           2
 I isoleucine          4.2         35           2
 K lysine              6.1         50           3
 L leucine            10.0         83           2
 M methionine          3.4         28           1
 N asparagine          4.0         33           1
 P proline             6.1         50           2
 Q glutamine           5.7         47           2
 R arginine            4.2         35           2
 S serine              9.4         78           3
 T threonine           8.0         66           4
 V valine              4.8         40           2
 W tryptophan          0.4          3           1
 Y tyrosine            2.7         22           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   hypoxia-inducible factor 1, alpha subunit isoform 1 [... 
HIF1A                 0.888   hypoxia-inducible factor 1, alpha subunit isoform 2 ...
EPAS1                 0.360   endothelial PAS domain protein 1 
HIF3A                 0.232   hypoxia inducible factor 3, alpha subunit isoform c ...
HIF3A                 0.231   hypoxia inducible factor 3, alpha subunit isoform a ...
HIF3A                 0.193   hypoxia inducible factor 3, alpha subunit isoform b ...
SIM2                  0.153   single-minded homolog 2 long isoform 
SIM2                  0.153   single-minded homolog 2 short isoform 
SIM1                  0.150   single-minded homolog 1 
NPAS3                 0.136   neuronal PAS domain protein 3 isoform 1 
NPAS3                 0.132   neuronal PAS domain protein 3 isoform 2 
NPAS1                 0.115   neuronal PAS domain protein 1 
ARNTL                 0.069   aryl hydrocarbon receptor nuclear translocator-like ...
ARNTL                 0.069   aryl hydrocarbon receptor nuclear translocator-like ...
ARNTL                 0.069   aryl hydrocarbon receptor nuclear translocator-like ...
ARNTL2                0.069   aryl hydrocarbon receptor nuclear translocator-like ...
CLOCK                 0.064   clock 
ARNT                  0.064   aryl hydrocarbon receptor nuclear translocator isofo...
NPAS2                 0.063   neuronal PAS domain protein 2 
ARNT                  0.063   aryl hydrocarbon receptor nuclear translocator isofor...
ARNT2                 0.060   aryl hydrocarbon receptor nuclear translocator 2 [Ho...
AHR                   0.059   aryl hydrocarbon receptor 
NPAS4                 0.040   neuronal PAS domain protein 4 
NCOA2                 0.031   nuclear receptor coactivator 2 
NCOA1                 0.030   nuclear receptor coactivator 1 isoform 2 
NCOA1                 0.030   nuclear receptor coactivator 1 isoform 3 
NCOA1                 0.030   nuclear receptor coactivator 1 isoform 1 
ARNT                  0.030   aryl hydrocarbon receptor nuclear translocator isofo...
NCOA3                 0.027   nuclear receptor coactivator 3 isoform a 
NCOA3                 0.027   nuclear receptor coactivator 3 isoform b 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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