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Search of human proteins with 66346693
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
(4588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 9180 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 4644 0.0
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 3547 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 1242 0.0
gi|16933557 dachsous 1 precursor [Homo sapiens] 922 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 899 0.0
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 719 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 499 e-140
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 473 e-132
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 453 e-126
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 357 2e-97
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 314 1e-84
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 314 1e-84
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 314 1e-84
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 314 1e-84
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 314 1e-84
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 314 1e-84
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 314 1e-84
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 314 1e-84
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 314 1e-84
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 311 7e-84
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 303 3e-81
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 288 7e-77
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 288 7e-77
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 288 7e-77
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 288 7e-77
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 288 7e-77
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 288 7e-77
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 288 7e-77
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 280 3e-74
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 9180 bits (23820), Expect = 0.0
Identities = 4588/4588 (100%), Positives = 4588/4588 (100%)
Query: 1 MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMG 60
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMG
Sbjct: 1 MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMG 60
Query: 61 VYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIV 120
VYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIV
Sbjct: 61 VYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIV 120
Query: 121 KALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT 180
KALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
Sbjct: 121 KALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT 180
Query: 181 NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM 240
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM
Sbjct: 181 NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM 240
Query: 241 AKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL 300
AKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL
Sbjct: 241 AKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL 300
Query: 301 QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF 360
QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
Sbjct: 301 QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF 360
Query: 361 KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLI 420
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLI
Sbjct: 361 KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLI 420
Query: 421 SILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480
SILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT
Sbjct: 421 SILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480
Query: 481 TVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA 540
TVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
Sbjct: 481 TVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA 540
Query: 541 SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ 600
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ
Sbjct: 541 SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ 600
Query: 601 LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYIN 660
LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYIN
Sbjct: 601 LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYIN 660
Query: 661 ITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL 720
ITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
Sbjct: 661 ITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL 720
Query: 721 PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL 780
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL
Sbjct: 721 PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL 780
Query: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE
Sbjct: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
Query: 841 IIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
IIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
Sbjct: 841 IIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
Query: 901 AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSG 960
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSG
Sbjct: 901 AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSG 960
Query: 961 QVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV 1020
QVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV
Sbjct: 961 QVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV 1020
Query: 1021 EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG 1080
EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
Sbjct: 1021 EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG 1080
Query: 1081 VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTS 1140
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTS
Sbjct: 1081 VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTS 1140
Query: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS 1200
EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS
Sbjct: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS 1200
Query: 1201 RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP 1260
RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP
Sbjct: 1201 RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP 1260
Query: 1261 DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEY 1320
DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEY
Sbjct: 1261 DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEY 1320
Query: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI
Sbjct: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
Query: 1381 SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT 1440
SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT
Sbjct: 1381 SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT 1440
Query: 1441 QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPL 1500
QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPL
Sbjct: 1441 QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPL 1500
Query: 1501 SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAP 1560
SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAP
Sbjct: 1501 SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAP 1560
Query: 1561 WFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIK 1620
WFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIK
Sbjct: 1561 WFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIK 1620
Query: 1621 TAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETV 1680
TAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETV
Sbjct: 1621 TAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETV 1680
Query: 1681 SIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGT 1740
SIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGT
Sbjct: 1681 SIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGT 1740
Query: 1741 NMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD 1800
NMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD
Sbjct: 1741 NMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD 1800
Query: 1801 KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE 1860
KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE
Sbjct: 1801 KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE 1860
Query: 1861 YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE 1920
YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE
Sbjct: 1861 YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE 1920
Query: 1921 GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFT 1980
GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFT
Sbjct: 1921 GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFT 1980
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFD 2040
QDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFD
Sbjct: 1981 QDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFD 2040
Query: 2041 REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI 2100
REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI
Sbjct: 2041 REQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI 2100
Query: 2101 RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGG 2160
RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGG
Sbjct: 2101 RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGG 2160
Query: 2161 NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITD 2220
NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITD
Sbjct: 2161 NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITD 2220
Query: 2221 GDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNP 2280
GDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNP
Sbjct: 2221 GDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNP 2280
Query: 2281 PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG 2340
PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG
Sbjct: 2281 PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG 2340
Query: 2341 LISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARIS 2400
LISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARIS
Sbjct: 2341 LISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARIS 2400
Query: 2401 EHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPF 2460
EHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPF
Sbjct: 2401 EHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPF 2460
Query: 2461 YSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD 2520
YSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD
Sbjct: 2461 YSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD 2520
Query: 2521 SGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC 2580
SGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC
Sbjct: 2521 SGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC 2580
Query: 2581 TVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSE 2640
TVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSE
Sbjct: 2581 TVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSE 2640
Query: 2641 SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL 2700
SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL
Sbjct: 2641 SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL 2700
Query: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL 2760
PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL 2760
Query: 2761 KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE 2820
KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE
Sbjct: 2761 KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE 2820
Query: 2821 NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR 2880
NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR
Sbjct: 2821 NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR 2880
Query: 2881 DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAIL 2940
DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAIL
Sbjct: 2881 DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAIL 2940
Query: 2941 STTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD 3000
STTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD
Sbjct: 2941 STTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD 3000
Query: 3001 GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITY 3060
GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITY
Sbjct: 3001 GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITY 3060
Query: 3061 TLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVND 3120
TLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVND
Sbjct: 3061 TLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVND 3120
Query: 3121 NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGI 3180
NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGI
Sbjct: 3121 NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGI 3180
Query: 3181 IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS 3240
IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS
Sbjct: 3181 IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS 3240
Query: 3241 EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE 3300
EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE
Sbjct: 3241 EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE 3300
Query: 3301 YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMAD 3360
YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMAD
Sbjct: 3301 YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMAD 3360
Query: 3361 DADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPR 3420
DADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPR
Sbjct: 3361 DADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPR 3420
Query: 3421 VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI 3480
VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI
Sbjct: 3421 VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI 3480
Query: 3481 VTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
VTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI
Sbjct: 3481 VTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLI 3600
YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLI
Sbjct: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLI 3600
Query: 3601 AHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYW 3660
AHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYW
Sbjct: 3601 AHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYW 3660
Query: 3661 RNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVT 3720
RNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVT
Sbjct: 3661 RNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVT 3720
Query: 3721 DIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVC 3780
DIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVC
Sbjct: 3721 DIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVC 3780
Query: 3781 LCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYV 3840
LCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYV
Sbjct: 3781 LCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYV 3840
Query: 3841 KYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVS 3900
KYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVS
Sbjct: 3841 KYRLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVS 3900
Query: 3901 VQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQG 3960
VQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQG
Sbjct: 3901 VQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQG 3960
Query: 3961 TRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASN 4020
TRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASN
Sbjct: 3961 TRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASN 4020
Query: 4021 PCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRG 4080
PCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRG
Sbjct: 4021 PCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRG 4080
Query: 4081 LYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGA 4140
LYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGA
Sbjct: 4081 LYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGA 4140
Query: 4141 LCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFV 4200
LCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFV
Sbjct: 4141 LCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFV 4200
Query: 4201 LCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSI 4260
LCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSI
Sbjct: 4201 LCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSI 4260
Query: 4261 PSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDS 4320
PSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDS
Sbjct: 4261 PSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPSNSPSDS 4320
Query: 4321 DSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNG 4380
DSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNG
Sbjct: 4321 DSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNG 4380
Query: 4381 YHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPE 4440
YHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPE
Sbjct: 4381 YHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPE 4440
Query: 4441 DFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSE 4500
DFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSE
Sbjct: 4441 DFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSE 4500
Query: 4501 PQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVM 4560
PQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVM
Sbjct: 4501 PQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVM 4560
Query: 4561 MSDYESGDDGHFEEVTIPPLDSQQHTEV 4588
MSDYESGDDGHFEEVTIPPLDSQQHTEV
Sbjct: 4561 MSDYESGDDGHFEEVTIPPLDSQQHTEV 4588
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 4644 bits (12046), Expect = 0.0
Identities = 2390/4605 (51%), Positives = 3183/4605 (69%), Gaps = 91/4605 (1%)
Query: 10 LLLLLFQHFGD-SDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAW 68
L+LLLF+ S G FTH YN TV ENSAA+TYV +MG+ + +W
Sbjct: 18 LILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSW 77
Query: 69 EVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTN 128
+++Y+IVSGD E FKAEE I+ DFCFLRIRTKGGN+AILNRE++D+Y LIVK + +
Sbjct: 78 DIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED 137
Query: 129 VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
+EA TKV +QVLD NDLRPLFSPT+YSV++ E+T +RTS+A+V+ATDADIG+NGEFYY F
Sbjct: 138 LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF 197
Query: 189 KDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE 248
K++ D+F++HPTSGVI L+GRL+Y E Y++EILA DRGMKLYG++G+SS AKL VHIE
Sbjct: 198 KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
Query: 249 QANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRS 308
+ NE AP I VT P L+++P YA+VTVDD D GANG+I S+SIVAGD L QF +
Sbjct: 258 RINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKE 317
Query: 309 FPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFE 368
EYK+K IDW+S P+GYNLTLQAKDKG+P + S++K +++ +P P++FE
Sbjct: 318 GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFE 377
Query: 369 KDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKR 428
K+VY ISEF+PP V +VK P + Y F +N +GLI P+
Sbjct: 378 KEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNT 437
Query: 429 QQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAV 488
+ ++LEVT + +V + + AN + PEF Q Y A +E+VP+GT+V+++SA
Sbjct: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 489 DPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYR 548
D D+GENGY+TYSIA+LN +PF I+ FTG +ST+E LD+E P +Y +RASDWG PYR
Sbjct: 498 DKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYR 557
Query: 549 REVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEA 608
E EV TI + N+NDN+PLFEK+ C+G I D VG IT VSAID DEL+LV+Y+I +
Sbjct: 558 HESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIIS 617
Query: 609 GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASH- 667
GNEL FF LNP+SGVL LK+SL + G K +LRITATDGEN A P+ INI+V
Sbjct: 618 GNELGFFYLNPDSGVLQLKKSLTNS-GIKNGNFALRITATDGENLADPMSINISVLHGKV 676
Query: 668 KLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVK 727
+ C ET VA+ LAEKLL K + + +ED F D +S+N P F + P+ + VK
Sbjct: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
Query: 728 ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDK 787
E+ PVG++++ + + D D+GFNGK+++ +S GN DSCF IDMETG LK+L P+DRE TD
Sbjct: 737 EDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL 796
Query: 788 YTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEAT 847
Y LNIT+YDLG PQK++WRLL + V DANDN P F+Q+SY V + E + +EIIQVEA
Sbjct: 797 YLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEAR 856
Query: 848 DKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQL 907
DKDLG NG VTYS++TDT F+I+S TG+V +A LDRE + +SLKIEARD+A QL
Sbjct: 857 DKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQL 916
Query: 908 FSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL 967
FS V +KV L+DVND P FIP +Y VKV EDLP GTVI WLE HDPDLG GQVRYSL+
Sbjct: 917 FSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976
Query: 968 DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNE 1027
+ G F++DK SGA+R+ ++LD+EK+Q YNLTVRAKDKG+PVSLSS +VEVEVVDVNE
Sbjct: 977 NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
Query: 1028 NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEE 1087
NLH P F F G+VKE++ +G+ V+ V+A DED+ RDGEI+YSIRDGSG+G F I +E
Sbjct: 1037 NLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDE 1096
Query: 1088 TGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPE 1147
+GVI +D LDRE+ YWLTV+ATD+GVVPL S IE+YIEVEDVNDNAP TSEP+YYP
Sbjct: 1097 SGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPV 1156
Query: 1148 IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQ 1207
+MENSPKDVSV+QI+A DPDSSSN+KL Y+ITSGNPQ FF+I+ KTGLITTTSRKLDREQ
Sbjct: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQ 1216
Query: 1208 QDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNAR 1267
Q EH LEVTVTD G PK + V+V++LDENDNKPQF +K Y+I+LPER+ R R
Sbjct: 1217 QAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD-----RKKR 1271
Query: 1268 REPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKA 1327
EP+Y A D+DEGPNAEISYSI DGN+ GKFFI+PKTG+VSS++ AG YDIL+IKA
Sbjct: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKA 1331
Query: 1328 VDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI 1387
VDNGRPQKSST RLHIEWI KP PS P++F+E F+ FTVMESD V ++GV+SV+P
Sbjct: 1332 VDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
Query: 1388 PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVI 1447
PLWFDI GGN+DS FD +KG GTI++AKPLDAEQ+S YN++VE TDGT +TQVFIKV+
Sbjct: 1392 PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVL 1451
Query: 1448 DTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRL 1507
D ND+ P+FS Y+V I ED P+TEILQI A D+DEK+KL YT+ SS D +S++KFR+
Sbjct: 1452 DNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRI 1511
Query: 1508 DPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSY 1567
DP+TG LYT+E+LDHEA +H L +MVRDQ+ P +RN AR++VNV D NDH+P+FT Y
Sbjct: 1512 DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLY 1571
Query: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDR 1627
+ V+ESAA+GS VLQVTALDKDKG+NAE++Y+IE+GN GN F I+PVLG I KE D
Sbjct: 1572 EASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDM 1631
Query: 1628 SNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1687
+ ++ L +K TD+GSPPMS VRI VT++DN+ PKF K+Y E++E V IG+ V
Sbjct: 1632 TTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVI 1691
Query: 1688 MVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLST 1747
+++A SQS+++YE+KDG+ F INP+SG I TQKALD+E Y LIIQ TNMAG+++
Sbjct: 1692 LISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS 1751
Query: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807
N TV + + DENDNAPVF+ ++Y+G +SE+A INS+V + N PLVIRA DAD + NALL
Sbjct: 1752 NATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALL 1811
Query: 1808 VYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTV 1867
VY IVE + +F +DSSTGAI T+ +LD+E + FHF V V D G+P+L AE V +
Sbjct: 1812 VYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI 1871
Query: 1868 HVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKF 1927
V D+ND PPVF + ++E LLLPTY GV+V+ V+ATD DS +L YS+ EG++ + F
Sbjct: 1872 EVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHF 1930
Query: 1928 SMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAV 1987
+D +G LT++N + Y L V+ SDG+F + V I VKE+ +S L FTQ YS
Sbjct: 1931 LIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTS 1990
Query: 1988 VKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047
+ EN+T +A++ A+GN +NEPL Y ILNP +FKI TSGV+ TTG PFDRE+QE +
Sbjct: 1991 ISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELY 2050
Query: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107
++VVE + E VA VVV+V +ED NDN+PVFV LPYYA V+VD E G +I VTA+D
Sbjct: 2051 ELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID 2110
Query: 2108 RDSGRNGEVHYYLKEHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
+D G NGEV Y L++ + HF+I P G + LK+ F D N EY VT++AKDGG P+ S
Sbjct: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLST 2170
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQ 2226
V +PIT++NKAMPVF+KPFY+A + E I++++P++ + A SPEG + Y I DGDPF Q
Sbjct: 2171 SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ 2230
Query: 2227 FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQ 2286
F I+F+TGV+ V++PLD+E AYKL+IRA+D+LTGA AEV VD++V+D+NDNPP+F Q
Sbjct: 2231 FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQP 2290
Query: 2287 SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLR 2346
+Y TLSEAS+IGT V+QV + D+DSE N+ + YQ+ + S D+FH+DSS+GLI R
Sbjct: 2291 TYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR 2350
Query: 2347 TLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHG 2406
LD+E + T+ VR++D G P+LSS+V+V + ++D+NDNPP+F Q IYE+ +SE AP G
Sbjct: 2351 MLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRG 2410
Query: 2407 HFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLS 2466
HFVTCV+A DADSSD D+L+YSILSGND F++DS +G+ITLSN + ++P YSLN+S
Sbjct: 2411 HFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVS 2470
Query: 2467 VSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH 2526
VSDG+F S+ QVH+ V+G NL+SPAF Q+ Y E+ EN T V+ V+ TDGD G YG
Sbjct: 2471 VSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQ 2530
Query: 2527 VTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVIL 2586
++Y I+NDFAKDRF I+ GQ+ T E+LDRE P E +S+ + A D GG+ FCTV VI+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIV 2590
Query: 2587 TDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD-SESVKEN 2645
D+NDNAPQF +Y ++ + +G V +V A D D+G+N+ ITY++ ++ S SV +
Sbjct: 2591 VDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650
Query: 2646 LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSE 2705
LEI+ +G + TK + L+N +FFV+AVD G P K S++ VY+ +LPPE LP F++
Sbjct: 2651 LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
Query: 2706 PFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS 2765
Y+FT++ED IG+ +D +R S V +S V G PE+N+ FVI++++G +KL+K
Sbjct: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKR 2770
Query: 2766 LDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGG 2825
LD ET+ + F + A D ++V +VDV I+V D NDN PVFE+S Y+ I+E +P G
Sbjct: 2771 LDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVG 2830
Query: 2826 SRVIQIRASDADSGTNGQVMYSL-DQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQ 2884
+++ Q+RA D D G NGQV YSL SQ +V+E+F I+ TGWI+TLK+LDHE +
Sbjct: 2831 TKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFT 2890
Query: 2885 IKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTD 2944
VVASD GE LSSTA+V V VTD+ND+ P F E+Y+G V E DP G V+A+LST D
Sbjct: 2891 FSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWD 2950
Query: 2945 ADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS 3004
D+ ++NRQV+Y ITGG+P G+FA+ +Q+EWKVYVK+PLDRE++D Y L ITATDG F
Sbjct: 2951 RDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFV 3010
Query: 3005 SKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLG 3064
++A+VEV V D NDNSPVC++ Y+ +PED+ K+I+++SA DADI SN I Y+L G
Sbjct: 3011 TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG 3070
Query: 3065 SGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPE 3124
SG +F L+P++GELKT LDRE VY L+ +ATDGGGRFCQ++I L LEDVNDN P
Sbjct: 3071 SGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPV 3130
Query: 3125 FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLE 3184
FS+D Y V+ENT LLTRVQA D D G+NRK++YSL DSA G FSI+ SGII LE
Sbjct: 3131 FSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILE 3190
Query: 3185 KPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDIL 3244
+PLDRE Q+ Y +S++A DQ + L++ TV ++VLDINDNPPVFE R+Y TV ED
Sbjct: 3191 QPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTS 3250
Query: 3245 VGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLT 3304
GT+VL V+A S+DI NAEITY I SGNE GKF I+ KTG + + E LDYE +YL
Sbjct: 3251 PGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLV 3310
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
VEA DGGTP+LS VATVN+N+TD+NDN P FSQD Y+ VISEDA++ SVI ++A+D D
Sbjct: 3311 VEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDS 3370
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTT 3424
N IH+SI++G++ + FT+DPV G VKV K LDRE +SGY+L VQA D+G P +T
Sbjct: 3371 QPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTA 3430
Query: 3425 TVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGN 3484
TVNID+SDVNDN+PVF+ NY+ +IQENKPVG S+LQLVVTD DS HNGPPF F+I++GN
Sbjct: 3431 TVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGN 3490
Query: 3485 DEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA 3544
+E+ F ++P G+L ++ + E Y+L V+ D+GKPQ S TYI +RVIEES + P
Sbjct: 3491 EEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPT 3550
Query: 3545 ILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLIAHKK 3604
+PLEIFI + +++ GGVIGKIHATDQD+YD LT++L + +LF V+S GK+IA
Sbjct: 3551 AIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGG 3610
Query: 3605 LDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQ 3664
LD G+Y+LNVSV+DG+F D+ VH+ Q+ EML +T+ IRF N++PE+FVG + F+
Sbjct: 3611 LDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFR 3670
Query: 3665 RALRN-ILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIE 3723
R LRN +L +++ ++I+S+Q LD+L VE S L+ K++++ +E
Sbjct: 3671 RTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLE 3730
Query: 3724 EIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCK 3783
I +RI + +K C+GLDC + C++ +S+D + T+STAR+SFV PR +R C C
Sbjct: 3731 NI--MRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCN 3788
Query: 3784 EGRCPPVHHGCEDDPCPEGSECVS-DPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKY 3842
G CP + C + PCP +CVS + C CP G+ G+C G +S++ GNSY+KY
Sbjct: 3789 GGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKY 3848
Query: 3843 RLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQ 3902
RL+EN + + KL +RLRT ++ ++MY R IL+I G+L ++ DCGSGPGI+ +
Sbjct: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGSGPGILGIS 3908
Query: 3903 SIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTR 3962
VNDG WH+V LE+N N+ L LD + AP +TL+ ++ ++FG ++ R
Sbjct: 3909 GRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIR 3968
Query: 3963 ---HGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCAS 4019
R QV +GF+GC+DS+ LN ELPL +K S+A + ++ GC L + C
Sbjct: 3969 SLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVL-YPDACKR 4027
Query: 4020 NPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCR 4079
+PCQ+GG C P+GGY C C + + G +CE + C PC GG+C F+C C+
Sbjct: 4028 SPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICNCK 4087
Query: 4080 GLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLH 4138
TG C+ C+ E C+NGG+C + +C C G+ G+ C L
Sbjct: 4088 AGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCG-----------LR 4136
Query: 4139 GALCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVV 4198
+ N H Y +G E IGI V + IF+LVV+
Sbjct: 4137 PVVVPN------IQAGHSY-------------------VGKEELIGIAVVLFVIFILVVL 4171
Query: 4199 FVLCRKMISRKKKHQAEPKDKHLGPATAFLQ--------RPYFDSKLNKNIYSDI-PPQV 4249
F++ RK + R K + PATA L R S +N+Y ++ PPQV
Sbjct: 4172 FIVFRKKVFR-KNYSRNNITLVQDPATAALLNKSNGIPFRNLRGSGDGRNVYQEVGPPQV 4230
Query: 4250 PVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPES--VHGHRKAVAVCSVAPN 4307
PVRP++YTP SDSR+NLD+ EH E +TF+PES + R+ V VCSVAPN
Sbjct: 4231 PVRPMAYTPCFQSDSRSNLDK--IVDGLGGEHQEMTTFHPESPRILTARRGVVVCSVAPN 4288
Query: 4308 LPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQS 4367
LP P SD DSI+K WD + K VD DP E S + S SEVQS
Sbjct: 4289 LPAVSPCR--SDCDSIRKNGWDAGTENKGVD-DP-------GEVTCFAGSNKGSNSEVQS 4338
Query: 4368 LSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPG 4427
LSSFQS+S DDN YHWDTSDWMP L DI+E PNYE D + + +++DYY G
Sbjct: 4339 LSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGGS-AHQGSTRELESDYYLG 4397
Query: 4428 GYDIESDFPPP-PEDFPAADEL-PPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFN 4485
GYDI+S++PPP E+F + D+L PPLP +F +Q+E++ P + + A +L R R +F+
Sbjct: 4398 GYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPVSLASTLSPDCRRRPQFH 4457
Query: 4486 LNQYLPNFYPLDMSEPQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYAST-A 4544
+QYLP +P +T G ++C PA +S+ +S++ S
Sbjct: 4458 PSQYLPP-HPF---PNETDLVGPPASCEFSTFAVSMNQGTEPTGPA-DSVSLSLHNSRGT 4512
Query: 4545 SCSDVSACCEV-ESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV 4588
S SDVSA C +SEV MSDYES + + IP +++Q T+V
Sbjct: 4513 SSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV 4557
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 3547 bits (9198), Expect = 0.0
Identities = 1849/4086 (45%), Positives = 2651/4086 (64%), Gaps = 92/4086 (2%)
Query: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
L + FTH YN T+ ENS+ KTYV KMG+Y+ P W VRY+I+SGD N+FK E
Sbjct: 26 LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85
Query: 87 EYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLR 146
EY++G+FCFLRIRTK NTA+LNREV+D YTLI++A EK +EA T+V V +LD NDL+
Sbjct: 86 EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLK 145
Query: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVL 206
PLFSP SY V++ E+ +++ I +V+ATDAD+G N EFYY+F R++MFAIHPTSGV+ +
Sbjct: 146 PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTV 205
Query: 207 TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSE 266
G+L+ +E+++LA DR K+ +G S+A L VH+E A P I +V ++P +
Sbjct: 206 AGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPD 265
Query: 267 LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWD 326
+ YA V VD GA ++ S+ +V GD + F+ ++S+ S E+ + ++ I+W
Sbjct: 266 SNDGTTYATVLVDANSSGA--EVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM 323
Query: 327 SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
+ G+NL+LQA+ P +S ++ H+ P K +KFEK VYR ++SEF+PP + V
Sbjct: 324 EYLHGFNLSLQARSGSGPYFYSQIRGFHL--PPSKLSSLKFEKAVYRVQLSEFSPPGSRV 381
Query: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKAS 446
VMV+ PA+ +L+YV K + F LN TGLI+ + + AH++L + TS +AS
Sbjct: 382 VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQAS 441
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLN 506
T V++ ++ N++ P F +++Y DEN+P GT+V++++A D D GENGYVTYSIA
Sbjct: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
Query: 507 HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566
+PF+ID + G +STS+ +DYELM R+YT R+RASDWG P+RRE EV + L NLNDN
Sbjct: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
Query: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626
P+FE++NC G+I +D VG+ I T+SAID DELQ ++Y+I +GNEL++F LN SGV+SL
Sbjct: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISL 621
Query: 627 KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAAS-HKLVNLQCEETGVAKMLAE 685
KR ++ + + +SL+ITA+DG+N+A+P +NITV H V + C++TGV +
Sbjct: 622 KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681
Query: 686 KLLQANKLHNQGEVEDIF--FDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTD 743
+L L NQ ++ F ++ +N + PQF P I V E+ P+ + + + +TD
Sbjct: 682 TILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATD 741
Query: 744 LDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA 803
D GFNGKLVY ++ GNE+ CF I++ETG+L + +PLD E T+ Y LN+TVYDLG PQK+
Sbjct: 742 PDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKS 801
Query: 804 AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT 863
+W+LL V V D NDN P F Y + +SED EV + I ++ D D NG V Y++++
Sbjct: 802 SWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLS 861
Query: 864 DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
T+ FS+ +TG + + LDRE + + LK+EARDQ + QLFS + ++LEDVNDN
Sbjct: 862 PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDN 921
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAV 983
P I + R+KV EDLP GTV+ +L+A DPDLG +G+VRY L+D G F VD ++GA+
Sbjct: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGAL 981
Query: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTV 1043
+ ++LDFE++ YNL++ A D G+P++ + C+VEV V+DVNENLHPP F+SFV +G V
Sbjct: 982 ILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQV 1041
Query: 1044 KEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTS 1103
+E++P G+ V+ V+A D+D+ DGE++Y +R G+G+ F I ++TG+I+T LDRE S
Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFAS 1101
Query: 1104 HYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEA 1163
+YWLTV A D+G VPLSS E+YIEV D NDN PQ S+ V+YP I E++P SV+Q++A
Sbjct: 1102 YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDA 1161
Query: 1164 FDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP 1223
+DPDSSS KL + ITSGN GFF IHP TGL+ +T+++LDRE +DEHILEVTV DNG P
Sbjct: 1162 WDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLL-STAQQLDRENKDEHILEVTVLDNGEP 1220
Query: 1224 PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGP 1283
+ +RV+V ILD NDN P F K + +RLPER P P+Y ++A+D DEG
Sbjct: 1221 SLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSP-----VSPGPVYRLVASDLDEGL 1275
Query: 1284 NAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI 1343
N ++YSIED +E F I+ TGVVSS AGEY+IL+IKA D+G+P S++ RLHI
Sbjct: 1276 NGRVTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHI 1334
Query: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVE-PPGIPLWFDITGGNYDSHF 1402
EWI P+PS P++F+E++++FTVME+DPV HM+GVISVE PG+ WF+I+GG+ D F
Sbjct: 1335 EWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGL-FWFNISGGDKDMDF 1393
Query: 1403 DVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVI-DTNDHRPQFSTSKY 1461
D++K TG+I++A+PLD ++SNYNLTVE TDG+ TI TQV I +I + N HRPQF ++Y
Sbjct: 1394 DIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRY 1453
Query: 1462 EVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLD 1521
EV +P+DT P E+L++ A+DQD+ LIYT+ S+DP S F+LDP++G L T KLD
Sbjct: 1454 EVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLD 1513
Query: 1522 -HEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSV 1580
QHTLTVMVRDQ++P+KRNF + ++V D N H P FT Y+ V ++ A G+
Sbjct: 1514 LGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE 1573
Query: 1581 VLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKAT 1640
+LQV A+D D+G NAEV YS+ GN F I+ +LG I A++LD++N A + L VKA
Sbjct: 1574 LLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE 1633
Query: 1641 DKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYE 1700
D+GSP ++ +V I V +D ++P F+ EY VE+ E++ +GS + +V+A S S V YE
Sbjct: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE 1693
Query: 1701 IKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
+++GN F +N +SG I TQK LD E + Y L I+G+NMAG T+ V+V + DEND
Sbjct: 1694 LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDEND 1753
Query: 1761 NAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYF 1820
NAP+F+++ + G ISE+A + S+++ N P VI A+D+DK++N+LLVY I+EP +F
Sbjct: 1754 NAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFF 1813
Query: 1821 AIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFA 1880
ID S G + V +DYE F F V VHD G+P LFA A V +HV D+ND PP F+
Sbjct: 1814 KIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFS 1873
Query: 1881 KPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQN 1940
+ +YE +++ P + G++++ V A+D D S++ YSI GN E ++ TG+++V N
Sbjct: 1874 EQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVLN 1929
Query: 1941 TTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAV 2000
L +LT+RASDG + VKI++ + + L+F QDVY A VKEN + + L +
Sbjct: 1930 PAFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVI 1989
Query: 2001 ITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPS 2060
+ A GN +N+ L Y +LN F + +++GVL T G FDREQQ+ ++ VEV + P
Sbjct: 1990 LGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
Query: 2061 AVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL 2120
VA +V+V +ED NDN P F +LPYY +++ TE G V+ V+A D D G NG V Y
Sbjct: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
Query: 2121 KEHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAM 2179
E + +F+I P LG+ISLKK F+ LNK Y + V+A+DGG P+ +E V +TV NK+
Sbjct: 2110 AEDYTYFRIDPYLGDISLKKPFDYQALNK-YHLKVIARDGGTPSLQSEEEVLVTVRNKSN 2168
Query: 2180 PVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVI 2239
P+F+ P+Y + E+I +++P++H QA SPEGL++ Y+I + +P FT +F TGV+ V
Sbjct: 2169 PLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVT 2228
Query: 2240 APLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG 2299
PLD+E+ + ++RATD+ G+ +E V+++V+D+NDNPP F+Q Y ++SE
Sbjct: 2229 GPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288
Query: 2300 TSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIF 2359
T V+Q+ A+D DS NR +SYQ+ + S F ++ STG +S ++ LDYE + +
Sbjct: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348
Query: 2360 VRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADS 2419
VRA+D G P L+ + +V V+V+D+NDNPP F Q YEA +SE A GH V V+A D DS
Sbjct: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408
Query: 2420 SDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVH 2479
D +L+Y ILSGN +HF I+S++GII++ NL + L Y+L + SDGVFR++ V+
Sbjct: 2409 RDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVY 2468
Query: 2480 VTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDR 2539
+ N +SP F Q+ YE ELAENA + T V+++ D DSG YG + Y I+N A ++
Sbjct: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528
Query: 2540 FYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRAT 2599
F IN GQI TL+KLDRE E+VI++++MA+D GG+VAFCTV +ILTD+NDN PQF+A+
Sbjct: 2529 FSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKAS 2588
Query: 2600 KYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKE 2659
+Y V+I S+ +K + V++VLA DADEG NAD+TY++ + + VK+ +EIN ++GV+ K+
Sbjct: 2589 EYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPE-DLVKDVIEINPVTGVVKVKD 2647
Query: 2660 SLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG 2719
SL+GLEN+ FF++A D G P S+V V ++++P ++ LPKFSEP YTF+ ED+P G
Sbjct: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEG 2707
Query: 2720 TEIDLIRA-EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI 2778
+EI +++A V+YSLV+G TPESN+D F +D +G +K+ K +DHE+TK YQ +
Sbjct: 2708 SEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDV 2767
Query: 2779 LARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADS 2838
+A C Q+ ++V+ V V+IQV D NDN PVFE+ PY+A + EN+P G+ VIQ+ A D D+
Sbjct: 2768 MAHCLQNT-DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDT 2826
Query: 2839 GTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQL 2898
G +GQV Y L V E FAI+ E+GWITTL+ELD E Y VVA DHG+ IQL
Sbjct: 2827 GRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL 2886
Query: 2899 SSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFI 2958
SS A+V V++TD ND+ PRF +E Y+G+V E+ G ++A L T DAD E NRQVT +I
Sbjct: 2887 SSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYI 2946
Query: 2959 TGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDAND 3018
T GDPLGQF + + +EW++ +K LDRE YLL +TA+DG F + VE+ VLD ND
Sbjct: 2947 TEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVND 3006
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE 3078
NSP C + LY+ + EDV PG I+++SATD D +NA+ITY+L G GA +FKL+P TGE
Sbjct: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGE 3066
Query: 3079 LKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENT 3138
L T T LDRE + V++L+ +ATDGGGR CQA I L +EDVNDNAP F A+ VF+NT
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
Query: 3139 EPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLS 3198
T + V A D D G N +++YSL DSA+G FSI+ +G+I+LEKPL QA L+
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
Query: 3199 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD 3258
++A D G P L+ GTV VSV+ + D PVF E+ V ED GTEVLQ+ +R
Sbjct: 3187 VRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR- 3245
Query: 3259 IEANAEIT-YSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSD 3317
AE T Y ++SGNE G+F +D++TG +++ +LD+E+S +Y+L++E + + SLSD
Sbjct: 3246 --PGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSD 3303
Query: 3318 VATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDG 3377
V TV VN+TD+N++ P F QD Y+T + E+A++ ++TV A D DGP NS I YS+I G
Sbjct: 3304 VTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGG 3363
Query: 3378 NQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNA 3437
NQ FTI P +GE++V K LDRE S Y+L ++A+D+G PP T + I V+DVNDN
Sbjct: 3364 NQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNP 3423
Query: 3438 PVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVL 3497
P F + NYS +QEN P+G VLQL+++D DS NGPP+ F I GN+ AF V P G L
Sbjct: 3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWL 3483
Query: 3498 LTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGE 3557
+T+ + R+ ++ Y LQ++ +D+G P LSSLT + + V E+S Y P+ LPLEIFIT +
Sbjct: 3484 VTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGED 3543
Query: 3558 EYSGGVIGKIHATDQDVYDTLTYSL--DPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVS 3615
E+ GG++GKIHATD+D DTLTYSL + + FSV + GK+IA + L G Y NV+
Sbjct: 3544 EFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVT 3603
Query: 3616 VTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRR 3675
V+DG FTT A + V++ V QE L + + F LTPEE V D+WRN QR L + L ++R
Sbjct: 3604 VSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLDIKR 3663
Query: 3676 NDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQ 3735
+I + SLQ +E +DVLL E ++L I S ++E +GV++ +
Sbjct: 3664 ANIHLASLQPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMP 3723
Query: 3736 KL-CAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHGC 3794
+ C G C + C V +D V T+STARLS +TPRHH C C
Sbjct: 3724 MVPCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSC------------ 3771
Query: 3795 EDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKYRLTENENKLEMK 3854
++ +G SYV+YR N
Sbjct: 3772 ---------------------------------NGTATRFSGQSYVRYRAPAARN---WH 3795
Query: 3855 LTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDC-GSGPGIVSVQSIQVNDGQWHA 3913
+ L+T A++++ T L++ G Q ++ C G G +S Q VND +WH+
Sbjct: 3796 IHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGNLSSQR-HVNDHEWHS 3854
Query: 3914 VALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGF 3973
+ +E RL++D + S P + L + ++ GG I S V GF
Sbjct: 3855 ILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHS-----SSNVSQGF 3909
Query: 3974 RGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPCQNGGVCNPSPA 4033
GC+D++ +N + L L + ++ A + E+ ++ C ++ C+ N C NGG C+ +
Sbjct: 3910 EGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCL--HSDYCSQNTCLNGGKCSWTHG 3967
Query: 4034 GGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSPY- 4092
GY CKC + G HCE C+ PCL GGTC++ G C C YTG RC++
Sbjct: 3968 AGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG 4027
Query: 4093 CKDEPC 4098
C + C
Sbjct: 4028 CSEGHC 4033
Score = 90.9 bits (224), Expect = 3e-17
Identities = 102/402 (25%), Positives = 148/402 (36%), Gaps = 109/402 (27%)
Query: 4085 QRCQLSPYCKDEPCKNGGTC-FDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCE 4143
Q C S YC C NGG C + G VC+C F G+ C+ + C+ PCL G C
Sbjct: 3943 QCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCI 4002
Query: 4144 NTHGSYHCNCSHEYRGRHCE----DAAPNQYVSTP----WNIGLAEGIGIVVFVAGIFLL 4195
+ CNC H Y G CE + + TP + G E + I V VA I +
Sbjct: 4003 LSPKGASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIIS 4062
Query: 4196 VV-VFVLCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPI 4254
V + CR+ S K +P L R + + + P + + P+
Sbjct: 4063 TVGLLFYCRRCKSHKPVAMEDPD---------LLAR-------SVGVDTQAMPAIELNPL 4106
Query: 4255 SYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCSVAPNLPPPPPS 4314
S + S NNL++ +++P E TF P S ++ VCSV P LPP
Sbjct: 4107 S------ASSCNNLNQPEPSKASVPN--ELVTFGPNS----KQRPVVCSVPPRLPPAAVP 4154
Query: 4315 NSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSE 4374
S SD++ + K +W
Sbjct: 4155 -SHSDNEPVIKRTW---------------------------------------------- 4167
Query: 4375 SCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVID---------EQTPLYSADPNAIDTDYY 4425
S ++ Y W P+ + E+P+ EV TP+ +PN + Y
Sbjct: 4168 SSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGL----Y 4223
Query: 4426 PGGYDIESDFPPPPEDFPAADELPPLPPEFSNQ-FESIHPPR 4466
G FP P E ++ PLPP +SNQ E + P R
Sbjct: 4224 GG-------FPFPLE---MENKRAPLPPRYSNQNLEDLMPSR 4255
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 1242 bits (3214), Expect = 0.0
Identities = 1120/3888 (28%), Positives = 1794/3888 (46%), Gaps = 300/3888 (7%)
Query: 72 YKIVSGDSENLFKAEEYI--LGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNT-N 128
Y+I+ G+ F+ + + G+ FL + +KGG L+REV Y L+V+ +K
Sbjct: 174 YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGG----LDREVTPQYQLLVEVEDKGEPK 229
Query: 129 VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
+V V V D ND P+F + Y +PE+ + +S+ +V+A DAD GTN + Y
Sbjct: 230 RRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL 289
Query: 189 KDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE 248
+D F + P +G+I + LD+ + Y + + A DRG+ ++ A+ + +
Sbjct: 290 QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP-----SLTGRAEALIQLL 344
Query: 249 QANECAPVIT----AVTLSPSELDRDP----AYAIVTVDDCDQ-GANGDIASLSIVAGDL 299
N+ PV+ T + +D + A++TV D D ANG+I S+ I+ G+
Sbjct: 345 DVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNI-SVQILGGNE 403
Query: 300 LQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK-GTPPQF-----SSVKVI 353
+ F V+S +K +D + P YNLT+ D G PP SSV +
Sbjct: 404 QRHFE-VQSSKVPNLSLIKVASALDRERIP-SYNLTVSVSDNYGAPPGAAVQARSSVASL 461
Query: 354 HVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYS----HLRYVFKSTPGKA 409
+ P F + VYR +SE APP + V + A S +LRY S G
Sbjct: 462 VIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLG 521
Query: 410 KFSLNYNTGLISILEP--VKRQQAAHFELEVTTSDRKASTKV-----LVKVLGANSNPPE 462
F ++ ++GL++ + R+ A+ L ++ D+ KV +V +L N P
Sbjct: 522 WFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPV 581
Query: 463 FTQT-AYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI--ANLNHVPFAIDHFTGAV 519
F+Q Y + EN P GT ++ L A D D G+NG V +S+ A + F +D +G +
Sbjct: 582 FSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRL 641
Query: 520 STSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIP 579
ST +LD E Y+L + A+D G P + + + ++L ++NDN+P+F + I
Sbjct: 642 STISSLDREEQA-FYSLLVLATDLGSPPQSSMARI-NVSLLDINDNSPVFYPVQYFAHIK 699
Query: 580 RDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
+ G ITTVSA D D V+Y I AG+ F +N SGV+S + +L +
Sbjct: 700 ENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDR---EE 755
Query: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
+ + L+I ATDG N +P +T+ N
Sbjct: 756 KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDN-------------------------- 789
Query: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
P S + V EN +G V ++++ +D N + Y ++
Sbjct: 790 ----------------PPVFSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLIT 831
Query: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAND 817
G++ F I+ TG L + +DRE Y L + + ++++ V D ND
Sbjct: 832 TGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDT---MVNITVKDLND 888
Query: 818 NPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGV 876
N P FLQ V V E+ + I Q +A D D G NG V YS+ + + F+I+ G
Sbjct: 889 NSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGT 948
Query: 877 VNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKV 936
+++ PLD H S +IE PQL S+V++ V + DVNDN P F +Y V +
Sbjct: 949 ISLLGPLD---VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTL 1005
Query: 937 REDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQV 996
E P + ++A D D G +G++ Y++ + G+ G + I +LD E +
Sbjct: 1006 SESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDR 1065
Query: 997 YNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTV 1056
Y L V A D+ LS+T V V + DVN+N P+F+S +E+ GS V V
Sbjct: 1066 YVLMVVASDRAVE-PLSATVNVTVILEDVNDNR--PLFNSTNYTFYFEEEQRAGSFVGKV 1122
Query: 1057 SAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES------TSHYWLTVF 1110
SA D+D +GE+RYS F++ +G I + + DRES T+ + TV
Sbjct: 1123 SAVDKDFGPNGEVRYSFEMVQPD--FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVI 1180
Query: 1111 ATDQGVV-PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
ATDQG+ PL +++ ++D+NDNAP+ + Y I E++ V+++ A D D
Sbjct: 1181 ATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEG 1240
Query: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIA 1229
+N + Y I GN + F+I +G +T KLD E + L + D+G+ P ++
Sbjct: 1241 NNGLIHYSIIKGNEERQFAIDSTSGQVTLIG-KLDYEATPAYSLVIQAVDSGTIPLNSTC 1299
Query: 1230 RVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISY 1289
+ + ILDENDN P F + + + E + E + V ATD D G NA++ Y
Sbjct: 1300 TLNIDILDENDNTPSFPKSTLFVDVLENMRIG-------ELVSSVTATDSDSGDNADLYY 1352
Query: 1290 SIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRPQKSSTTR--LHIE 1344
SI N HG F I P TG + + F Y L+I A D GRP +SST +H+
Sbjct: 1353 SITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYK-LNITAKDQGRPPRSSTMSVVIHVR 1411
Query: 1345 WISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL-----WFDITGGNYD 1399
+ PS P +S ++E+ P+ + ++ P + + I
Sbjct: 1412 DFNDNPPSFPPGDIFKS-----IVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRG 1466
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQ------VFIKVIDTNDHR 1453
+HF +D+ GTI +D E + + LTV+A D I T+ V I V D ND+
Sbjct: 1467 NHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNV 1526
Query: 1454 PQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPAT 1511
P F + P + I A D DE ++ Y + + F +D +
Sbjct: 1527 PMFISQNALAADPSAVIGSV-LTTIMAADPDEGANGEIEYEIING----DTDTFIVDRYS 1581
Query: 1512 GSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRV 1571
G L + L Q ++V D+ +R + + + P FT Y +
Sbjct: 1582 GDLRVASAL---VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITIL 1638
Query: 1572 YESAAVGSVVLQVTALDKDKGKNAEVLYSI-----ESGNIGNSFMIDPVLGSIKTAKELD 1626
E +G+ V+ + A +G A V Y I E +G F I G I+TA LD
Sbjct: 1639 KEGEPIGTNVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697
Query: 1627 RSNQA-EYDLMVKATDKGSP-PMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGS 1684
R A Y + V A +K + P ++ V I + ++ P F + + + E + GS
Sbjct: 1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757
Query: 1685 FVGMVTAH-----SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQG 1739
+ +TA + + V Y I G D+F I+P SG +I + LD E Y+L+++
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA 1816
Query: 1740 TNMAGL-STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAAD 1798
+ GL S++ + + + D ND+ P F + Y+ I E S+V I A D
Sbjct: 1817 DD--GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAA-------ILATD 1867
Query: 1799 ADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLF 1858
D N + Y + E F ++ TG + LDYE + TV+ D G
Sbjct: 1868 DDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFT- 1926
Query: 1859 AEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSI 1918
V +++D+ND PP+F+ Y SL+ G V+ N TDAD SQL YSI
Sbjct: 1927 ---TIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI 1983
Query: 1919 TEGNIGEKFSMDYKTGALTVQNTTQLRSR--YELTVRASD------GRFAGLTSVKINVK 1970
G+ +F++D K G L V S+ Y L V+ D RF V I +
Sbjct: 1984 ASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL 2042
Query: 1971 ESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEP---LFYHILNP-DRRFKIS 2026
+ ++ F + + + +T +T+ +P + P + Y +LNP +F I
Sbjct: 2043 DVNDNPPTFLSPKLTYIPE--NTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIG 2100
Query: 2027 RTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY 2086
G + TG DRE+ + + V T++ +PS + V V+V D NDN P+F Y
Sbjct: 2101 TIDGEVRLTGE-LDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALY 2159
Query: 2087 YAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQIGPL-GEISLKKQFEL 2143
+ +T G I V A D D G NG+V Y + + + F+I + G I++ K +
Sbjct: 2160 KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDR 2219
Query: 2144 DTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESI-QVHSP 2200
+ Y +TV A D G+ + V I ++ N +PVFE YS + E++ +
Sbjct: 2220 EK-TPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT 2278
Query: 2201 VVHVQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT 2257
++ V A + K+ Y + G+ + FT++ + G + V LD E + L I AT
Sbjct: 2279 ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSAS-GELGVTQSLDRETKERFVLMITAT 2337
Query: 2258 DS----LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSE 2313
DS LTG +++IVDD+NDN P FA ++Y T+ E + GT V+ V A+D+D+
Sbjct: 2338 DSGSPALTGTGT---INVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS 2394
Query: 2314 PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPT-LSS 2372
N I ++ G +S+ F ++ STG I LD E +T+ V D G P LSS
Sbjct: 2395 KNAVI--RIIGGNSQ----FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSS 2448
Query: 2373 DVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432
V V VTD+NDNPP F+ Y I G FV V DAD +L YS LSG
Sbjct: 2449 STSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSG 2507
Query: 2433 NDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHS-PA 2491
+ + F ID G I + A + +S+++ G F + VTV N P
Sbjct: 2508 RNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK-DGGSFPKTDSTTVTVRFVNKADFPK 2566
Query: 2492 FLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH-VTYHIVNDFAKDRFYINE-RGQIF 2549
E EN P+ +LV TT S + G ++Y+I + + F I++ GQ+
Sbjct: 2567 VRAKEQTFMFPENQPVSSLV----TTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVS 2622
Query: 2550 TLEKLDRETPAEKVISVRLMAKDAGGKV--AFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607
+ LD E + V+ + A+D G ++ +++ + D NDNAP F+ + I
Sbjct: 2623 ISQPLDFEKIQKYVVWIE--ARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILE 2680
Query: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667
+ + ++ V A D D G N + Y I + +++ + IN +G I + L +
Sbjct: 2681 NLSP-RKILTVSAMDKDSGPNGQLDYEIV--NGNMENSFSINHATGEIRSVRPLDREKVS 2737
Query: 2668 FFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA 2727
+ +++ D GSPS+ + V V + IL P+FS+ F V E+ P+G + +
Sbjct: 2738 HYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAH-VPENSPLGYTVTRVTT 2796
Query: 2728 EHSGTVL-----YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARC 2782
+ YS++ + P F I+ +G + + + L+ E T Y+ + A
Sbjct: 2797 SDEDIGINAISRYSIMDASLP-------FTINPSTGDIVISRPLNREDTDRYRIRVSAH- 2848
Query: 2783 TQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNG 2842
D S DV+I V D NDN+P F + Y E GS+V Q+ A+D D G+NG
Sbjct: 2849 ---DSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNG 2905
Query: 2843 QVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR--------DNYQIKVVASDHGE 2894
QV Y + +SQS E F IN TG I + L ++ + + V +SD G+
Sbjct: 2906 QVFYFI-KSQS----EYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK 2960
Query: 2895 KIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQV 2954
+S T + + + D ND+ P+F Y V+++ G + ++ D +N +V
Sbjct: 2961 PSLISETTVT-INIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEV 3019
Query: 2955 TYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEV 3011
YFI+ + LG+F ++ W + V L + N+ +T+TA D SS+A V +
Sbjct: 3020 EYFISNDNHLGKFKLDN-DTGW-ISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHI 3077
Query: 3012 KVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-- 3069
V + N ++P ++ S TIPE G ++ +SA D D N I Y++ SG E+
Sbjct: 3078 TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI-SSGNEEGI 3136
Query: 3070 FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSA 3127
F +N TG L + LD E + + + A DGG R S+ + + DVNDN+P F +
Sbjct: 3137 FAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLS 3196
Query: 3128 DPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPL 3187
D Y TV EN GT + + ATDAD+G N I Y++ S F I+ +G+I + L
Sbjct: 3197 DDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFL 3256
Query: 3188 DRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGT 3247
D E + Y L++KA + R + TV + + N+ P F + Y +SE GT
Sbjct: 3257 DFETKQSYHLTVKAFNVPDEERCSFA-TVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGT 3315
Query: 3248 EVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEA 3307
V +V+A+ RD+ + E+ Y I + F I+ KTG +++ LD E L V A
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLA 3375
Query: 3308 TDGGTPSLSDV--ATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG- 3364
+ G+ +D+ TVNV V D ND P+F+ + Y+ ISE + V V A D+D
Sbjct: 3376 KNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSI 3434
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTT 3424
PS S Y I GN+ +F+I+P G++ VT LDRET+ Y L+V A D+G+P +
Sbjct: 3435 PSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSA 3494
Query: 3425 TVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPF-FFTIVTG 3483
++ + + D+NDN P+ + V+ ENK G V+ L TD D N PF ++ + TG
Sbjct: 3495 SLLVTLEDINDNGPMLTVSEGEVM--ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTG 3552
Query: 3484 NDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPP 3543
F ++ GVL T+ I R++ + L V D+G PQ+SS + I VI+++ P
Sbjct: 3553 PATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPS 3612
Query: 3544 AILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLIAHK 3603
+EIF+ G + GG++G + D DV D+ SL + +LFS+ L +
Sbjct: 3613 QSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCSLTSGVTSLFSIPGGTCDLNSQP 3672
Query: 3604 KLDIGQYLLNVSVTDGKFTTV-ADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRN 3662
+ G + L V DG +TV ++I V + ++++I +R T ++F+ +++ +
Sbjct: 3673 RSTDGTFDLTVLSNDGVHSTVTSNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNHYLH 3732
Query: 3663 FQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDI 3722
F R + L +Q+ S + E + +L V++ + ++ + S +
Sbjct: 3733 FLRIASSQLTGLGTAVQLYS--AYEENNRTFLLAAVKRNHNQYVNPSGVATFFESIKEIL 3790
Query: 3723 EEIIGVRILNVFQKLCAGLDCP-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCL 3781
GV++ +V C C C +++V SV+ + + + V + +C
Sbjct: 3791 LRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAV-SSVLKSRESLPVIIVANEPLQPFLCK 3849
Query: 3782 CKEGR----CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ 3825
C G C C PC G C + +C CP G G+
Sbjct: 3850 CLPGYAGSWCEIDIDECLPSPCHSGGTCHN--LVGGFSCSCPDGFTGR 3895
Score = 1130 bits (2922), Expect = 0.0
Identities = 977/3345 (29%), Positives = 1555/3345 (46%), Gaps = 250/3345 (7%)
Query: 375 EISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH- 433
++ E PP T V ++ P ++ ++ + A F++N +TG + + R+
Sbjct: 50 QVLEEQPPGTLVGTIQTRPGFT-----YRLSESHALFAINSSTGALYTTSTIDRESLPSD 104
Query: 434 -FELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDE 492
L V +S T+V V V N N P F + F E+ G V+ +A D D
Sbjct: 105 VINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDI 164
Query: 493 GENG--YVTYSIANLNHV----------PFAIDHFTGAVSTSENLDYELMPRVYTLRIRA 540
G NG + +Y I N P F VS LD E+ P+ Y L +
Sbjct: 165 GSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKG-GLDREVTPQ-YQLLVEV 222
Query: 541 SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ 600
D G P RR + +T+ ++NDN P+F + + +P D VG + V+A DADE
Sbjct: 223 EDKGEPKRRGY-LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGT 281
Query: 601 LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYIN 660
+ +E F ++P +G+++++ L +F +
Sbjct: 282 NADIRYRLQDEGTPFQMDPETGLITVREPL---------------------DFEARRQYS 320
Query: 661 ITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL 720
+TV A + V TG A+ L + LL N N V+ +F + S A
Sbjct: 321 LTVQAMDRGVP---SLTGRAEALIQ-LLDVN--DNDPVVKFRYFPATSRYA--------- 365
Query: 721 PTGIQVKENQPVGSSVIFMNSTDLDT-GFNGKLVYAVSGGNEDSCFMIDM----ETGMLK 775
V EN VG+ V + TD D+ NG + + GGNE F + ++K
Sbjct: 366 ----SVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIK 421
Query: 776 ILSPLDRETTDKYTLNITVYD-LGIPQKAAWRL------LHVVVVDANDNPPEFLQESYF 828
+ S LDRE Y L ++V D G P AA + L + V D ND+PP F Q+ Y
Sbjct: 422 VASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYR 481
Query: 829 VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSVTGVVNIARP--LD 884
V +SE+ S + + ATD D G N ++ YSIV+ F I +G+V LD
Sbjct: 482 VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLD 541
Query: 885 RELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI-PPNYRVKVREDLPEG 943
REL + L I ARDQ ++ +V V+L DVND P F P Y V V E+ P G
Sbjct: 542 RELASQIVLNISARDQGVHPKVSYAQLV--VTLLDVNDEKPVFSQPEGYDVSVVENAPTG 599
Query: 944 TVIMWLEAHDPDLGQSGQVRYSL--LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTV 1001
T ++ L A D DLG +G VR+SL + +F +D +SG + + LD E++ Y+L V
Sbjct: 600 TELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLV 659
Query: 1002 RAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDE 1061
A D G P SS + V ++D+N+N PVF +KE+ P GS + TVSA D
Sbjct: 660 LATDLGSPPQ-SSMARINVSLLDINDN--SPVFYPVQYFAHIKENEPGGSYITTVSATDP 716
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSS 1121
D +G ++YSI G F++ ++GVI T LDRE + Y L + ATD G + +
Sbjct: 717 DLGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPN 775
Query: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181
+ I V D DN P S+ Y + EN V + A D +SN + Y IT+G
Sbjct: 776 QAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTG 833
Query: 1182 NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDN 1241
+ +G F+I+ TG + TT+ +DRE+Q + L+V V G+ T+ + VK D NDN
Sbjct: 834 DQKGMFAINQVTGQL-TTANVIDREEQSFYQLKV-VASGGTVTGDTMVNITVK--DLNDN 889
Query: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF 1301
P FLQ + + E + ++ A D DEG N + YS++ N F
Sbjct: 890 SPHFLQAIESVNVVENWQAGHS-------IFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFA 941
Query: 1302 IEPKTGVVS--SKRFSAAGEYDILSIKAVDNGRPQKSSTTRL--HIEWISKPKPSLEPIS 1357
I K G +S AG Y I I A D G PQ SS+ L ++ ++ P + +S
Sbjct: 942 INEKNGTISLLGPLDVHAGSYQI-EILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000
Query: 1358 FEESFFTFTVMESDPVAHMIGVISVEPPGI----PLWFDITGGNYDSHFDVDKGTGTIIV 1413
+E T+ ES+PV + + + I GN F + G + +
Sbjct: 1001 YE-----VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYI 1054
Query: 1414 AKPLDAEQKSNYNLTVEATDGTTTILT---QVFIKVIDTNDHRPQFSTSKYEVVIPEDTA 1470
LD E + Y L V A+D L+ V + + D ND+RP F+++ Y E+
Sbjct: 1055 KSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQR 1114
Query: 1471 PETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQH 1528
+ + ++SAVD+D ++ Y+ + + F L +G + + + D E++ +
Sbjct: 1115 AGSFVGKVSAVDKDFGPNGEVRYSFE-----MVQPDFELHAISGEITNTHQFDRESLMRR 1169
Query: 1529 ------TLTVMVRDQDVPVK-RNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ TV+ DQ +P ++ A + V + D ND+AP F Y+ + ESAA + V
Sbjct: 1170 RGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQV 1229
Query: 1582 LQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATD 1641
L+V+A D D+G N + YSI GN F ID G + +LD Y L+++A D
Sbjct: 1230 LRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVD 1289
Query: 1642 KGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS----- 1696
G+ P++ ++ I + ++ +P F V++ E + IG V VTA S
Sbjct: 1290 SGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNAD 1349
Query: 1697 VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVH 1754
+ Y I N F I+P++G+I K LDFET +Y L I + S+ +V++H
Sbjct: 1350 LYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIH 1409
Query: 1755 LQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEP 1814
++D NDN P F + I E+ I + V++ + A D D D N L Y I++
Sbjct: 1410 VRDFNDNPPSFPPGDIFKSIVENIPIGTSVIS-------VTAHDPDADINGQLSYTIIQQ 1462
Query: 1815 SVH-TYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYA-ANVTVHVIDI 1872
+F ID G I+T +D E ++F TV+ +D P YA NVT+ V D+
Sbjct: 1463 MPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDL 1522
Query: 1873 NDCPPVFAKPLYEASLLLPT-YKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDY 1931
ND P+F A P+ G + T+ A D D A ++ Y I G+ + F +D
Sbjct: 1523 NDNVPMFIS--QNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDR 1579
Query: 1932 KTGALTVQNT-TQLRSRYELTVRASD-GRFAGLTSVKINVKESKESHLKFTQDVYSAVVK 1989
+G L V + + Y L V A+D G ++ ++ + FTQ Y ++K
Sbjct: 1580 YSGDLRVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILK 1639
Query: 1990 ENSTEAETLAVITAIGNPINE-PLFYHILN-------PDRRFKISRTSGVLSTTGTPFDR 2041
E + I A +E P+ Y+I++ R F I R +G++ T DR
Sbjct: 1640 EGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI-LDR 1698
Query: 2042 EQQEAFDVVVEVTEEHKPSA---VAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098
EQ +V+V K +A V++ ++D NDN PVF V+ + G
Sbjct: 1699 EQGACL-YLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757
Query: 2099 VIRYVTAVDRDSGRNGEVHY-YLKEHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVA 2156
I +TA+D D G N V Y + + F+I P G++ ++ + + +K L +V
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSL--LVR 1815
Query: 2157 KDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQA---NSPEGLK 2213
D G + + + ++ +N P F +P YS +I E S V + A +S +
Sbjct: 1816 ADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGE 1875
Query: 2214 VFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIV 2273
+ Y + + D F +N TGV N+ LD+E Y L++RA D G + V +
Sbjct: 1876 ITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDG-GGQFTTIRVYFNI 1934
Query: 2274 DDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHF 2333
D+NDNPP+F+ SY+ +L E +G++V+ TD+D N ++Y + S F
Sbjct: 1935 LDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLG--QF 1992
Query: 2334 HVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTL-----SSDVIVTVDVTDLNDNPP 2388
VD + G++ +L+ LD E + + V+ D +P + +S V++ + D+NDNPP
Sbjct: 1993 TVDKN-GVLKVLKALDRESQSFYNLVVQVHD--LPQIPASRFTSTAQVSIILLDVNDNPP 2049
Query: 2389 LFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT 2448
F I E+ P V +A D DS ++Y++L+ +K F I + G +
Sbjct: 2050 TFLSPKL-TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK-FSIGTIDGEVR 2107
Query: 2449 LSNLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
L+ Y+L + +D SST+V V V+ N ++P F Q Y+VE+ EN
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENT 2167
Query: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVI 2564
T +++V DGD G G V Y IVN F I+ G I + LDRE +
Sbjct: 2168 LTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHL 2227
Query: 2565 SVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSS-AAKGTSVVKVLASDA 2623
+V+ + + + TV+++L D ND P F + Y VN+ + ++++V+A D
Sbjct: 2228 TVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD 2287
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSK 2683
D GSN+ ++Y + +E +N SG + +SL E F + A D+GSP+
Sbjct: 2288 DRGSNSKLSYVLFGGNE---DNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPAL 2344
Query: 2684 ESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR---AEHSGTVLYSLVKG 2740
+ V + +P F+ Y T+ ED P GT++ L+ A+ S + ++ G
Sbjct: 2345 TGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGG 2404
Query: 2741 NTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVK 2800
N+ F I+ +G++ LD ET Y ++ + +S V + V
Sbjct: 2405 NS-------QFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVT 2457
Query: 2801 DANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESF 2860
D NDN P F+ PY I GS V + +DAD G N ++ YSL S E F
Sbjct: 2458 DVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNS----EKF 2513
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSP-PRFT 2919
I+ G I L+ + + V D G + ST VTV VN + P+
Sbjct: 2514 HIDPLRGAIMAAGPLNGASEVTFSVHV--KDGGSFPKTDSTT---VTVRFVNKADFPKVR 2568
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
A+ E+ P ++ L TT S ++Y+I G+ F ++ + + V
Sbjct: 2569 AKEQTFMFPENQP----VSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQ--VS 2622
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDV 3036
+ +PLD EK Y++ I A DG FSS +++ VLD NDN+P+ ++ + I E++
Sbjct: 2623 ISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL 2682
Query: 3037 LPGKLIMQISATDADIRSNAEITYTLLGSGAE-KFKLNPDTGELKTSTPLDREEQAVYHL 3095
P K I+ +SA D D N ++ Y ++ E F +N TGE+++ PLDRE+ + Y L
Sbjct: 2683 SPRK-ILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVL 2741
Query: 3096 LVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD 3153
++++D G + +++ + D NDNAP FS ++ V EN+ G +TRV +D D
Sbjct: 2742 TIKSSDKGSPSQSTSVKVMINILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDED 2800
Query: 3154 AGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTAT 3213
G+N YS++D A F+IN +G I + +PL+RE Y + + A D G T +
Sbjct: 2801 IGINAISRYSIMD-ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG----WTVS 2855
Query: 3214 GTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGN 3273
V + V DINDN P F Y E +G++V QV+A D +N ++ Y I S +
Sbjct: 2856 TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS 2915
Query: 3274 EHGKFSIDSKTGAVFIIENLDYE--------SSHEYYLTVEATDGGTPSLSDVATVNVNV 3325
E+ F I++ TG +F + L Y+ + + + V ++D G PSL TV +N+
Sbjct: 2916 EY--FRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973
Query: 3326 TDINDNTPVFSQDTYTTVISEDAVLEQSVITVMA-DDADGPSNSHIHYSIIDGNQGSSFT 3384
D NDN P F + Y T ++++ + +I V A DD D NS + Y I + N F
Sbjct: 2974 VDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFK 3033
Query: 3385 IDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGN 3444
+D G + V L + + +TV A D G+PP + TV+I V++ N + P FS+ +
Sbjct: 3034 LDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSH 3093
Query: 3445 YSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAI 3503
S I E+ +G V + D D++ NG ++I +GN+E F +N G+L + A+
Sbjct: 3094 MSATIPESHSIGSIVRTVSARDRDAAMNG-LIKYSISSGNEEGIFAINSSTGILTLAKAL 3152
Query: 3504 KRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGV 3563
+ + + + D G + + + VI+ + P L + F T SG
Sbjct: 3153 DYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTT 3212
Query: 3564 IGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLD 3606
+ ++ATD D + Y++ +LF + G + LD
Sbjct: 3213 VIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLD 3257
Score = 1118 bits (2891), Expect = 0.0
Identities = 908/3021 (30%), Positives = 1429/3021 (47%), Gaps = 187/3021 (6%)
Query: 724 IQVKENQPVGSSVIFMNSTDLDTGFNG--KLVYAVSGGNEDSCFMIDM------ETGMLK 775
+ KE+ G VI +TD D G NG Y + GNE F +D+ E L
Sbjct: 142 VTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLH 201
Query: 776 ILSP--LDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSE 833
++S LDRE T +Y L + V D G P++ + ++V V D NDNPP F Y V E
Sbjct: 202 LVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPE 261
Query: 834 DKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSL 893
D V S ++QV A D D G N + Y + + F +D TG++ + PLD E + ++SL
Sbjct: 262 DAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSL 321
Query: 894 KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT----FIPPNYR-VKVREDLPEGTVIMW 948
++A D R P L + L DVNDN P + P R V E+ GTV+
Sbjct: 322 TVQAMD--RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVAL 379
Query: 949 LEAHDPDL-GQSGQVRYSLLDHGE-GNFDVDKLS----GAVRIVQQLDFEKKQVYNLTVR 1002
L D D +G + +L E +F+V +++ LD E+ YNLTV
Sbjct: 380 LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVS 439
Query: 1003 AKDK-GKP-----VSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTV 1056
D G P + SS + + V D+N+ HPPVFS V + + E+AP GS V +
Sbjct: 440 VSDNYGAPPGAAVQARSSVASLVIFVNDIND--HPPVFSQQVYRVNLSEEAPPGSYVSGI 497
Query: 1057 SAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET--SDRLDRESTSHYWLTVFATDQ 1114
SA D D+ + +RYSI G+G+G F I E +G++ T S LDRE S L + A DQ
Sbjct: 498 SATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQ 557
Query: 1115 GVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYP-EIMENSPKDVSVVQIEAFDPDSSSNDK 1173
GV P S+ ++ + + DVND P S+P Y ++EN+P ++ + A D D N
Sbjct: 558 GVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGT 617
Query: 1174 LMYKITSG-NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVI 1232
+ + + + F + P +G ++T S LDRE+Q + L V TD GSPP+S++AR+
Sbjct: 618 VRFSLQEAETDRRSFRLDPVSGRLSTIS-SLDREEQAFYSLLVLATDLGSPPQSSMARIN 676
Query: 1233 VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE 1292
V +LD NDN P F Y + E E + V ATD D G N + YSI
Sbjct: 677 VSLLDINDNSPVFYPVQYFAHIKENEPGG-------SYITTVSATDPDLGTNGTVKYSIS 729
Query: 1293 DGNEHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPK 1350
G + +F + ++GV+S++ E L I A D G Q + + I +
Sbjct: 730 AG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQD 788
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI--PLWFDITGGNYDSHFDVDKGT 1408
P F + ++F V E+ + + +G +S + + + IT G+ F +++ T
Sbjct: 789 ---NPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVT 845
Query: 1409 GTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPED 1468
G + A +D E++S Y L V A+ GT T T V I V D ND+ P F + V + E+
Sbjct: 846 GQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVEN 905
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
I Q AVD DE ++Y+L+ ++P +L F ++ G++ LD A
Sbjct: 906 WQAGHSIFQAKAVDPDEGVNGMVLYSLK--QNPKNL--FAINEKNGTISLLGPLDVHA-G 960
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
+ + ++ D VP + + V V D ND++P F SY+ + ES V S +V A
Sbjct: 961 SYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQA 1020
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
DKD G N E+ Y+I GN G++F I P G + ELDR Q Y LMV A+D+ P
Sbjct: 1021 SDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEP 1079
Query: 1647 MSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQ-----SSVVYEI 1701
+S +V + + ++ P F S Y+ E GSFVG V+A + V Y
Sbjct: 1080 LSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSF 1139
Query: 1702 KDGNTGDAFDINPHSGTIITQKALDFETL------PIYTLIIQGTNMA---GLSTNTTVL 1752
+ F+++ SG I D E+L +++ + T+ L TV
Sbjct: 1140 E--MVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVH 1197
Query: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIV 1812
V+++D NDNAP F++ Y ISESA+ + VL + A+D D+ +N L+ Y I+
Sbjct: 1198 VYMKDINDNAPKFLKDFYQATISESAANLTQVLR-------VSASDVDEGNNGLIHYSII 1250
Query: 1813 EPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
+ + FAIDS++G + + LDYE T + +Q D GT L + N + ++D
Sbjct: 1251 KGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLN--IDILDE 1308
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
ND P F K +L G V +V ATD+DS + L YSIT N FS+
Sbjct: 1309 NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPN 1368
Query: 1933 TGALTVQNTT--QLRSRYELTVRASD-GR--FAGLTSVKINVKESKESHLKFTQ-DVYSA 1986
TG++ + + +S Y+L + A D GR + SV I+V++ ++ F D++ +
Sbjct: 1369 TGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKS 1428
Query: 1987 VVKENSTEAETLAVITA--IGNPINEPLFYHILNPDRR---FKISRTSGVLSTTGTPFDR 2041
+V EN ++ +TA IN L Y I+ R F I G + T DR
Sbjct: 1429 IV-ENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTI-YTNAEIDR 1486
Query: 2042 EQQEAFDVVVEVTEEHKPSAVAHVVVK---VIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098
E F++ V+ ++ P +K ++V D NDN P+F++ A +G
Sbjct: 1487 EFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALA-ADPSAVIGS 1545
Query: 2099 VIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKD 2158
V+ + A D D G NGE+ Y + I L+ L Y + V A D
Sbjct: 1546 VLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPSQLIYNLIVSATD 1605
Query: 2159 GGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV---F 2215
G + + I + PVF +P Y + E + + V+ ++A SP G + +
Sbjct: 1606 LGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEY 1665
Query: 2216 YSIT----DGDPFSQFTINFNTGVINVIAPLDFEAHPA-YKLSIRATDSLTG--AHAEVF 2268
Y ++ + FTI +TG+I A LD E Y + + A + T
Sbjct: 1666 YIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAE 1725
Query: 2269 VDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK 2328
V+I + DINDNPPVF +T+ E G+ ++Q+ A D+D N ++Y + S
Sbjct: 1726 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTII---SG 1782
Query: 2329 SHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPP 2388
+ D F +D +G + R LD E+ ++++ VRA DG SSD+ + + V+D+ND+ P
Sbjct: 1783 ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTP 1839
Query: 2389 LFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT 2448
F + +Y I E G V + A D DS ++ Y + ++ F ++ TG+
Sbjct: 1840 KFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFN 1899
Query: 2449 LSNLHRHALKPFYSLNLSVSDGVFRSST-QVHVTVIGGNLHSPAFLQNEYEVELAENAPL 2507
L+ L + ++ +Y L + DG + +T +V+ ++ N + P F N Y L EN P+
Sbjct: 1900 LTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPV 1959
Query: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPA--EKVIS 2565
+ V+ TD D GI +TY I + + +F +++ G + L+ LDRE+ + V+
Sbjct: 1960 GSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQ 2019
Query: 2566 VR-LMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDAD 2624
V L A + V++IL D NDN P F + K I + T V K A+D D
Sbjct: 2020 VHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENTPIDTVVFKAQATDPD 2078
Query: 2625 EGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKE 2684
G N+ I Y + + I + G + L E +T V A D G PS
Sbjct: 2079 SGPNSYIEYTL---LNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLS 2135
Query: 2685 SVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVK 2739
S V V +L P F++ Y ++E+ GT+I + A +G V Y +V
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195
Query: 2740 GNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
GNT ++ F ID +G + + K LD E T Y ++ A + + VSI +
Sbjct: 2196 GNT-----NQEFRIDSVTGAITVAKPLDREKTPTYHLTVQA-TDRGSTPRTDTSTVSIVL 2249
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSR-VIQIRASDADSGTNGQVMYSLDQSQSVEVIE 2858
D ND PVFE SPY + ENL R ++Q+ A D D G+N ++ Y L
Sbjct: 2250 LDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFT 2309
Query: 2859 SFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRF 2918
A +G + + LD E ++ + + + A+D G L+ T ++V V DVND+ P F
Sbjct: 2310 LSA----SGELGVTQSLDRETKERFVLMITATDSGSP-ALTGTGTINVIVDDVNDNVPTF 2364
Query: 2919 TAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKV 2978
++ Y T+ ED P G + +++ +DAD+ ++ I GG+ QF + + ++
Sbjct: 2365 ASKAYFTTIPEDAPTGTDVLLVNASDADA---SKNAVIRIIGGN--SQFTIN--PSTGQI 2417
Query: 2979 YVKKPLDREKRDNYLLTITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPE 3034
LDRE +DNY L + +D SS V V V D NDN P + Y IP
Sbjct: 2418 ITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPS 2477
Query: 3035 DVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYH 3094
LPG + ++ TDADI N+E+ Y+L G +EKF ++P G + + PL+ + +
Sbjct: 2478 PTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFS 2537
Query: 3095 LLVRATDGGGRFCQASIVLTLEDVND-NAPEFSADPYAITVFENTEPGTLLTRVQATDAD 3153
+ V+ DGG S +T+ VN + P+ A EN +L+T + T +
Sbjct: 2538 VHVK--DGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTI--TGSS 2593
Query: 3154 AGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTAT 3213
Y + F I++L+G + + +PLD E Y + ++A D G P ++
Sbjct: 2594 LRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP-PFSSY 2652
Query: 3214 GTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGN 3273
+ ++VLD+NDN P+F+ + + + E+ L ++L V A +D N ++ Y I++GN
Sbjct: 2653 EKLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNGN 2711
Query: 3274 EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTP 3333
FSI+ TG + + LD E Y LT++++D G+PS S V +N+ D NDN P
Sbjct: 2712 MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAP 2771
Query: 3334 VFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVK 3393
FSQ ++ + E++ L +V V D D N+ YSI+D + FTI+P G++
Sbjct: 2772 RFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDAS--LPFTINPSTGDIV 2828
Query: 3394 VTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENK 3453
+++ L+RE Y + V A D+G +T V I V+D+NDNAP FSR +Y + E
Sbjct: 2829 ISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELT 2885
Query: 3454 PVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVN-PQGVLLTSSAIKRKEK---- 3508
+G V Q+ TD D NG F+F + + F +N G + +K +
Sbjct: 2886 EIGSKVTQVFATDPDEGSNGQVFYF---IKSQSEYFRINATTGEIFNKQILKYQNVTGFS 2942
Query: 3509 ----DHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
+ + V +D GKP L S T + I +++ + P L + F + G +
Sbjct: 2943 NVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKL 3002
Query: 3565 GKIHATDQDVYDTLT-----YSLDPQMDNLFSVSSTGGKLIAHKKL-DIGQ-YLLNVSVT 3617
++ A D + + S D + + TG +A + D+ Q + + V+
Sbjct: 3003 IRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAK 3062
Query: 3618 D-GKFTTVADITVHIRQVTQE 3637
D G + TVHI VT+E
Sbjct: 3063 DKGNPPLSSQATVHI-TVTEE 3082
Score = 1096 bits (2835), Expect = 0.0
Identities = 982/3553 (27%), Positives = 1625/3553 (45%), Gaps = 271/3553 (7%)
Query: 178 IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGI 237
I T F Y + +FAI+ ++G + T +D E L +D + SS
Sbjct: 64 IQTRPGFTYRLSESHALFAINSSTGALYTTSTID--------RESLPSDVINLVVLSSAP 115
Query: 238 SSMAKLTVHIEQANECAPVI---TAVTLSPSELDRDPAYAIVTVDDCDQGANG-DIASLS 293
+ ++ V + N+ APV + V + + T D D G+NG D S
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYR 175
Query: 294 IVAGDLLQQFRTVRSFPGSKE---YKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSV 350
I+ G+ +FR + S E + + GG+D + P Y L ++ +DKG P + +
Sbjct: 176 IIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTP-QYQLLVEVEDKGEPKRRGYL 234
Query: 351 KVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVF--KS 404
+V +VT P F Y+A + E A + V+ V A A + +RY +
Sbjct: 235 QV-NVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEG 293
Query: 405 TPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSN 459
TP F ++ TGLI++ EP+ + + L V DR + L+++L N N
Sbjct: 294 TP----FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDN 349
Query: 460 PP-----EFTQTAYKAAFDENVPIGTTVMSLSAVDPDE-GENGYVTYSIANLN-----HV 508
P F T+ A+ DEN +GT V L+ D D NG ++ I N V
Sbjct: 350 DPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV 409
Query: 509 PFAIDHFTGAVSTSENLDYELMPRVYTLRIRASD-WGLPYRREVEVLATIT-----LNNL 562
+ + + LD E +P Y L + SD +G P V+ +++ +N++
Sbjct: 410 QSSKVPNLSLIKVASALDRERIPS-YNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDI 468
Query: 563 NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFSLNPN 620
ND+ P+F + + + G ++ +SA D D ++Y I +GN L +F ++ +
Sbjct: 469 NDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEH 528
Query: 621 SGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVA 680
SG+++ S GL ++ AS ++N+ + GV
Sbjct: 529 SGLVTTGSS--GGLDREL--------------------------ASQIVLNISARDQGVH 560
Query: 681 KMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMN 740
++ L L VN P F + V EN P G+ ++ +
Sbjct: 561 PKVSYAQLVVTLL--------------DVNDEKPVFSQPEGYDVSVVENAPTGTELLMLR 606
Query: 741 STDLDTGFNGKLVYAVSGGNED-SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGI 799
+TD D G NG + +++ D F +D +G L +S LDRE Y+L + DLG
Sbjct: 607 ATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGS 666
Query: 800 PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTY 859
P +++ ++V ++D NDN P F YF + E++ S I V ATD DLG NG V Y
Sbjct: 667 PPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKY 726
Query: 860 SI-VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
SI D F +++ +GV++ LDRE + + L+I A D + + +V +++
Sbjct: 727 SISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSP--NQAIVTITVL 784
Query: 919 DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978
D DNPP F Y V E++ G + + A DL + + D +G F +++
Sbjct: 785 DTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQ-KGMFAINQ 843
Query: 979 LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFV 1038
++G + +D E++ Y L V A +++ V + V D+N+N P F +
Sbjct: 844 VTGQLTTANVIDREEQSFYQLKVVASGG----TVTGDTMVNITVKDLNDN--SPHFLQAI 897
Query: 1039 EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098
E V E+ G + A D D +G + YS++ + +F I E+ G I LD
Sbjct: 898 ESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD 956
Query: 1099 RESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV 1158
+ S Y + + A+D GV LSS + + + V DVNDN+P + Y + E+ P +
Sbjct: 957 VHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF 1015
Query: 1159 VQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVT 1218
+++A D DS +N ++ Y I GN F I P L + +LDRE QD ++L V +
Sbjct: 1016 FKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKS--ELDRELQDRYVLMVVAS 1073
Query: 1219 DNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
D P S V V + D NDN+P F Y E ++ + V A D
Sbjct: 1074 DRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAG-------SFVGKVSAVD 1126
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSS-----------KRFSAAGEYDILSIKA 1327
KD GPN E+ YS E F + +G +++ +R +A + ++ A
Sbjct: 1127 KDFGPNGEVRYSFE--MVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVI---A 1181
Query: 1328 VDNGRPQ---KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEP 1384
D G PQ +T ++++ I+ P F + F+ T+ ES A++ V+ V
Sbjct: 1182 TDQGIPQPLKDQATVHVYMKDINDNAP-----KFLKDFYQATISES--AANLTQVLRVSA 1234
Query: 1385 PGIP------LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI 1438
+ + + I GN + F +D +G + + LD E Y+L ++A D T
Sbjct: 1235 SDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP 1294
Query: 1439 LTQ---VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTL 1493
L + I ++D ND+ P F S V + E+ + ++A D D + L Y++
Sbjct: 1295 LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI 1354
Query: 1494 QSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVS 1553
+ + F + P TGS++ ++KLD E + L + +DQ P + + +V++V
Sbjct: 1355 TGTNNH---GTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411
Query: 1554 DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYS-IESGNIGNSFMI 1612
D ND+ P F + E+ +G+ V+ VTA D D N ++ Y+ I+ GN F I
Sbjct: 1412 DFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471
Query: 1613 DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE---ITSVRIFVTIADNASPKFTS 1669
D V G+I T E+DR ++L VKA D+ P + + +V I VT ++ P F S
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531
Query: 1670 KEYSVELSETVSIGSFVGMVTA-----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKA 1724
+ ++ + IGS + + A + + YEI +G+T D F ++ +SG + A
Sbjct: 1532 QN-ALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVASA 1589
Query: 1725 LDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVV 1784
L L IY LI+ T++ +T + + + + PVF Q +Y ++ E I + V
Sbjct: 1590 LVPSQL-IYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNV 1648
Query: 1785 LTDRNVPLVIRAADADKDSNALLVYHIV-----EPSVHTYFAIDSSTGAIHTVLSLDYEE 1839
++ I AA + + S A + Y+IV E +V F I TG I T LD E+
Sbjct: 1649 IS-------IEAA-SPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQ 1700
Query: 1840 TSIFHFTVQVHDMGTPRLFAE-YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKV 1898
+ + V V+ + F A V + + DIND PPVF + + ++ G K+
Sbjct: 1701 GACL-YLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKI 1759
Query: 1899 ITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTVRASD 1956
+ + A DAD A + + Y+I G + F +D ++G L T + + RS+Y L VRA D
Sbjct: 1760 MQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818
Query: 1957 GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP--INEPLFY 2014
G + + I V + + KF++ VYS + E++ +A I A + +N + Y
Sbjct: 1819 GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITY 1878
Query: 2015 HILNPDRR---FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIV 2071
I+N D F ++ +GV + T D E Q+ + + V + V ++
Sbjct: 1879 -IVNEDDEDGIFFLNPITGVFNLTRL-LDYEVQQYYILTVRAEDGGGQFTTIRVYFNIL- 1935
Query: 2072 EDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE--HFQI 2129
D NDN P+F Y + + VG + D D G N ++ Y + F +
Sbjct: 1936 -DVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTV 1994
Query: 2130 GPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPA----FSAEVIVPITVMNKAMPVFEKP 2185
G + + K + ++ + LV V PA +A+V + + +N P F P
Sbjct: 1995 DKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSP 2054
Query: 2186 FYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSITDGDPF-SQFTINFNTGVINVIAPLD 2243
+ I E+ + + V QA P+ G + T +P ++F+I G + + LD
Sbjct: 2055 KLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELD 2113
Query: 2244 FEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSV 2302
E Y L++ ATD + V ++V DINDN P+FAQ Y V ++E ++ GT +
Sbjct: 2114 REEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDI 2173
Query: 2303 VQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRA 2362
+QV A D D N + Y + + ++ F +DS TG I++ + LD E++ + + V+A
Sbjct: 2174 IQVFAADGDEGTNGQVRYGIV--NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQA 2231
Query: 2363 VDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEH-APHGHFVTCVKAYDADSSD 2421
D G + V++ + D+ND P+FE Y + E+ + V A D D
Sbjct: 2232 TDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGS 2291
Query: 2422 IDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDG--VFRSSTQVH 2479
KL Y + GN+ F + ++ + +L R + F + + G + ++
Sbjct: 2292 NSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTIN 2351
Query: 2480 VTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDR 2539
V V N + P F Y + E+AP T V+ V +D D+ + I+ +
Sbjct: 2352 VIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS--KNAVIRIIG--GNSQ 2407
Query: 2540 FYIN-ERGQIFTLEKLDRETPAEKVISVRLMAKDAGGK---VAFCTVNVILTDDNDNAPQ 2595
F IN GQI T LDRET + V + DAG + +V V +TD NDN P+
Sbjct: 2408 FTINPSTGQIITSALLDRETKDNYTLVV--VCSDAGSPEPLSSSTSVLVTVTDVNDNPPR 2465
Query: 2596 FRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVI 2655
F+ Y +I S G+ V V +DAD G N+++ Y++ + E I+ L G I
Sbjct: 2466 FQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRN---SEKFHIDPLRGAI 2522
Query: 2656 TTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSED 2715
L G TF V D GS K V V+ + + PK TF E+
Sbjct: 2523 MAAGPLNGASE--VTFSVHVKDGGSFPKTDSTTVTVRFV-NKADFPKVRAKEQTFMFPEN 2579
Query: 2716 VPIGTEIDLIRAE--HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKW 2773
P+ + + I + Y + GN +F ID+ +G++ + + LD E +
Sbjct: 2580 QPVSSLVTTITGSSLRGEPMSYYIASGNL-----GNTFQIDQLTGQVSISQPLDFEKIQK 2634
Query: 2774 YQFSILARCTQDDHEMVASVD-VSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIR 2832
Y I AR +S + + I V D NDN+P+F+ P+ + I+ENL +++ +
Sbjct: 2635 YVVWIEAR--DGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL-SPRKILTVS 2691
Query: 2833 ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH 2892
A D DSG NGQ+ Y + + SF+IN TG I +++ LD EK +Y + + +SD
Sbjct: 2692 AMDKDSGPNGQLDYEIVNG---NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK 2748
Query: 2893 GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINR 2952
G Q +S ++ + + D ND+ PRF ++I+ V E+ P G + ++T+D D IN
Sbjct: 2749 GSPSQSTSVKVM-INILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDI-GINA 2805
Query: 2953 QVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVK 3012
Y I D F + + + + +PL+RE D Y + ++A D ++ V +
Sbjct: 2806 ISRYSIM--DASLPFTINPSTGD--IVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIF 2861
Query: 3013 VLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKL 3072
V D NDN+P +T Y PE G + Q+ ATD D SN ++ Y + S +E F++
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY-FIKSQSEYFRI 2920
Query: 3073 NPDTGEL--------KTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNA 3122
N TGE+ + T + +V ++D G + ++ + + D NDNA
Sbjct: 2921 NATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980
Query: 3123 PEFSADPYAITVFENTEPGTLLTRVQA-TDADAGLNRKILYSLI-DSADGQFSINELSGI 3180
P+F Y V +N + GT L RV A D D GLN ++ Y + D+ G+F ++ +G
Sbjct: 2981 PQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGW 3040
Query: 3181 IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS 3240
I + L +L + +++ A D+G P L++ TV ++V + N + P F AT+
Sbjct: 3041 ISVASSLISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099
Query: 3241 EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE 3300
E +G+ V V A RD N I YSI SGNE G F+I+S TG + + + LDYE +
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159
Query: 3301 YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMAD 3360
+ +T+ A DGG + + +V VNV D+NDN+PVF D Y + E+A +VI + A
Sbjct: 3160 HEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNAT 3219
Query: 3361 DADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPR 3420
DAD +N+ I Y+ + + F IDP G + LD ET Y LTV+A + R
Sbjct: 3220 DADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEER 3278
Query: 3421 VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI 3480
+ TVNI + N+ P F Y I E P G V ++ +D D +G + +
Sbjct: 3279 CSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHY--L 3336
Query: 3481 VTGND-EKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEE 3538
+ GN +K F++N + G + S + R++++ L+V + G + + + + + V
Sbjct: 3337 IFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVL 3396
Query: 3539 SIYPPAILPLEIFITSSGEEYSGGV-IGKIHATDQD---VYDTLTYSLDPQMDN-LFSVS 3593
P I L I+ E G + + A D D + +Y + +N FS++
Sbjct: 3397 DANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSIN 3456
Query: 3594 STGGKLIAHKKLD 3606
G++ +LD
Sbjct: 3457 PQTGQITVTAELD 3469
Score = 1095 bits (2833), Expect = 0.0
Identities = 1047/3645 (28%), Positives = 1662/3645 (45%), Gaps = 297/3645 (8%)
Query: 133 TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFK--- 189
T+VRV V D ND P+F S V+ E+++ + +ATD+DIG+NG + S++
Sbjct: 119 TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIR 178
Query: 190 -DRTDMFAIHPT---SGV-----IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM 240
+ F + T SG +V G LD T Y++ + D+ G
Sbjct: 179 GNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDK-----GEPKRRGY 233
Query: 241 AKLTVHIEQANECAPVITAVTLS---PSELDRDPAYAIVTVDDCDQGANGDIASLSIVAG 297
++ V ++ N+ PV + P + + V D D+G N DI G
Sbjct: 234 LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEG 293
Query: 298 DLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTS 357
Q + + +D+++ Y+LT+QA D+G P + +
Sbjct: 294 TPFQM--------DPETGLITVREPLDFEARR-QYSLTVQAMDRGVPSLTGRAEALIQLL 344
Query: 358 PQFKAGPV----KFEKDVYRAEISEFAPPNTPVVMVKAIPAYS-----HLRYVFKSTPGK 408
PV F A + E A T V ++ A S ++ +
Sbjct: 345 DVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQ 404
Query: 409 AKFSLNY----NTGLISILEPVKRQQAAHFELEVTTSD------------RKASTKVLVK 452
F + N LI + + R++ + L V+ SD R + +++
Sbjct: 405 RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIF 464
Query: 453 VLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP-FA 511
V N +PP F+Q Y+ E P G+ V +SA D D G N + YSI + N + F
Sbjct: 465 VNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFH 524
Query: 512 IDHFTGAVST--SENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLF 569
I +G V+T S LD EL ++ L I A D G+ + L +TL ++ND P+F
Sbjct: 525 ISEHSGLVTTGSSGGLDRELASQI-VLNISARDQGVHPKVSYAQL-VVTLLDVNDEKPVF 582
Query: 570 -EKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQI-EAGNELDFFSLNPNSGVLS 625
+ + ++ + G ++ + A D D + V++ + EA + F L+P SG LS
Sbjct: 583 SQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLS 642
Query: 626 LKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAE 685
SL + +F+SL + ATD + +S +N+
Sbjct: 643 TISSLD---REEQAFYSLLVLATD---------LGSPPQSSMARINV------------- 677
Query: 686 KLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLD 745
LL N D+ V + F +KEN+P GS + +++TD D
Sbjct: 678 SLLDIN-------------DNSPVFYPVQYF-------AHIKENEPGGSYITTVSATDPD 717
Query: 746 TGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAW 805
G NG + Y++S G+ S F ++ ++G++ LDRE Y L I D G Q
Sbjct: 718 LGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQ 776
Query: 806 RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT-- 863
++ + V+D DNPP F Q +Y V E+ + + V A+ DL N +++Y I T
Sbjct: 777 AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGD 834
Query: 864 DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
F+I+ VTG + A +DRE Q + LK+ A + +V ++++D+NDN
Sbjct: 835 QKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGT-----VTGDTMVNITVKDLNDN 889
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAV 983
P F+ V V E+ G I +A DPD G +G V YSL + + F +++ +G +
Sbjct: 890 SPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTI 949
Query: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTV 1043
++ LD Y + + A D G P LSS+ + V V DVN+N PVF + T+
Sbjct: 950 SLLGPLDVHAGS-YQIEILASDMGVP-QLSSSVILTVYVHDVNDN--SPVFDQLSYEVTL 1005
Query: 1044 KEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTS 1103
E PV S V A D+D+ +GEI Y+I +G+ F I + G + LDRE
Sbjct: 1006 SESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQD 1064
Query: 1104 HYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEA 1163
Y L V A+D+ V PLS+ + + + +EDVNDN P + Y E V ++ A
Sbjct: 1065 RYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSA 1124
Query: 1164 FDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE----QQDEHILEVTV-- 1217
D D N ++ Y P F +H +G IT T + DRE ++ + TV
Sbjct: 1125 VDKDFGPNGEVRYSFEMVQPD--FELHAISGEITNT-HQFDRESLMRRRGTAVFSFTVIA 1181
Query: 1218 TDNGSP-PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
TD G P P A V V + D NDN P+FL+ FY+ + E A + V A
Sbjct: 1182 TDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESA-------ANLTQVLRVSA 1234
Query: 1277 TDKDEGPNAEISYSIEDGNEHGKFFIEPKTG---VVSSKRFSAAGEYDILSIKAVDNGRP 1333
+D DEG N I YSI GNE +F I+ +G ++ + A Y ++ I+AVD+G
Sbjct: 1235 SDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLV-IQAVDSGTI 1293
Query: 1334 QKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI----SVEPPGIPL 1389
+ST L+I+ + + + SF +S V+E+ + ++ + S L
Sbjct: 1294 PLNSTCTLNIDILDE---NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADL 1350
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD---GTTTILTQVFIKV 1446
++ ITG N F + TG+I +AK LD E +S Y L + A D + V I V
Sbjct: 1351 YYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHV 1410
Query: 1447 IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTL--QSSRDPLSL 1502
D ND+ P F I E+ T ++ ++A D D +L YT+ Q R
Sbjct: 1411 RDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRG---- 1466
Query: 1503 KKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVK-RNFA--RIVVNVSDTNDHA 1559
F +D G++YT+ ++D E + LTV DQ VP++ R +A + + V+D ND+
Sbjct: 1467 NHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNV 1526
Query: 1560 PWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSI 1619
P F + + SA +GSV+ + A D D+G N E+ Y I +G+ ++F++D G +
Sbjct: 1527 PMFISQNALA-ADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDL 1584
Query: 1620 KTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSET 1679
+ A L S Q Y+L+V ATD G T + I + D P FT +Y L E
Sbjct: 1585 RVASALVPS-QLIYNLIVSATDLGPERRKSTTELTIILQGLD--GPVFTQPKYITILKEG 1641
Query: 1680 VSIGSFVGMVTA----HSQSSVVYEI-----KDGNTGDAFDINPHSGTIITQKALDFETL 1730
IG+ V + A S++ V Y I ++ G F I H+G I T LD E
Sbjct: 1642 EPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQG 1701
Query: 1731 PIYTLI----IQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLT 1786
L+ I+ + + V + LQD NDN PVF + E+ S ++
Sbjct: 1702 ACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQ 1761
Query: 1787 DRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFT 1846
+ A DAD+ +NAL+ Y I+ F ID +G + LD E S +
Sbjct: 1762 -------LTAMDADEGANALVTYTIIS-GADDSFRIDPESGDLIATRRLDRERRSKYSLL 1813
Query: 1847 VQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDA 1906
V+ D ++ N+TV D+ND P F++P+Y + T G V + ATD
Sbjct: 1814 VRADD---GLQSSDMRINITVS--DVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDD 1868
Query: 1907 DSSAFSQLIYSITEGNIGEKFSMDYKTGA--LTVQNTTQLRSRYELTVRASDGRFAGLTS 1964
DS ++ Y + E + F ++ TG LT +++ Y LTVRA DG T+
Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG-GQFTT 1927
Query: 1965 VKI--NVKESKESHLKFTQDVYSAVVKENSTEAETLAV--ITAIGNPINEPLFYHILNPD 2020
+++ N+ + ++ F+ + YS + EN T+ V +T + IN L Y I + D
Sbjct: 1928 IRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGD 1987
Query: 2021 R--RFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSA---VAHVVVKVIVEDQN 2075
+F + + +GVL DRE Q +++VV+V + + A + V +I+ D N
Sbjct: 1988 SLGQFTVDK-NGVLKVL-KALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVN 2045
Query: 2076 DNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHY-YLKEHHEHFQIGPL-G 2133
DN P F++ P + +T + V+ A D DSG N + Y L F IG + G
Sbjct: 2046 DNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDG 2104
Query: 2134 EISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA--EVIVPITVMNKAMPVFEKPFYSAEI 2191
E+ L + + + ++ Y +TVVA D G P+ S+ EV+V + +N P+F + Y EI
Sbjct: 2105 EVRLTGELDREEVS-NYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEI 2163
Query: 2192 AESIQVHSPVVHV-QANSPEGL--KVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHP 2248
E+ + ++ V A+ EG +V Y I +G+ +F I+ TG I V PLD E P
Sbjct: 2164 NENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTP 2223
Query: 2249 AYKLSIRATDSLTGAHAEV-FVDIIVDDINDNPPVFAQQSYAVTLSE-ASVIGTSVVQVR 2306
Y L+++ATD + + V I++ DIND PVF Y+V + E + +++QV
Sbjct: 2224 TYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVV 2283
Query: 2307 ATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGG 2366
A D D N +SY +FG + D+ S++G + + ++LD E + + + A D G
Sbjct: 2284 ARDDDRGSNSKLSYVLFGG---NEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSG 2340
Query: 2367 MPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQ 2426
P L+ + V V D+NDN P F + Y I E AP G V V A DAD+S ++
Sbjct: 2341 SPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR 2400
Query: 2427 YSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDG----VFRSSTQVHVTV 2482
I+ GN F I+ +TG I S L K Y+L + SD SST V VTV
Sbjct: 2401 --IIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTV 2456
Query: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542
N + P F + Y + + V V TD D G + Y + + ++F+I
Sbjct: 2457 TDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHI 2515
Query: 2543 NE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGG--KVAFCTVNVILTDDNDNAPQFRAT 2599
+ RG I L+ +E SV + KD G K TV V + D P+ RA
Sbjct: 2516 DPLRGAIMAAGPLN--GASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKAD-FPKVRAK 2570
Query: 2600 KYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKE 2659
+ + + V + S ++Y I S ++ +I++L+G ++ +
Sbjct: 2571 EQTFMFPENQPVSSLVTTITGSSL---RGEPMSYYIA--SGNLGNTFQIDQLTGQVSISQ 2625
Query: 2660 SLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG 2719
L + + + ++ A D G P S + + +L P F E + + E++
Sbjct: 2626 PLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPR 2685
Query: 2720 TEIDLIRAEH----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQ 2775
+ + + +G + Y +V G N + SF I+ +G ++ + LD E Y
Sbjct: 2686 KILTVSAMDKDSGPNGQLDYEIVNG-----NMENSFSINHATGEIRSVRPLDREKVSHYV 2740
Query: 2776 FSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASD 2835
+I + + SV V I + D NDN+P F S + A + EN P G V ++ SD
Sbjct: 2741 LTIKS-SDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSD 2798
Query: 2836 ADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEK 2895
D G N YS+ ++ F IN TG I + L+ E D Y+I+V A D G
Sbjct: 2799 EDIGINAISRYSI-----MDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWT 2853
Query: 2896 IQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVT 2955
+ V + VTD+ND+ PRF+ Y E G + + TD D E N QV
Sbjct: 2854 VSTD----VTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPD-EGSNGQVF 2908
Query: 2956 YFITGGDPLGQFAVETIQNEWKVYVK----KPLDREKRDNYLLTITATD---GTFSSKAI 3008
YFI + T + K +K + + +T++D + S+
Sbjct: 2909 YFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT 2968
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPG-KLIMQISATDADIRSNAEITYTLLGSG- 3066
V + ++D+NDN+P K+ Y + ++V G KLI + D D N+E+ Y +
Sbjct: 2969 VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNH 3028
Query: 3067 AEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPE 3124
KFKL+ DTG + ++ L + + + V A D G QA++ +T+ + N + PE
Sbjct: 3029 LGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPE 3088
Query: 3125 FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLID-SADGQFSINELSGIIQL 3183
FS + T+ E+ G+++ V A D DA +N I YS+ + +G F+IN +GI+ L
Sbjct: 3089 FSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTL 3148
Query: 3184 EKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243
K LD EL + +++ A+D G R T +V V+V+D+NDN PVF +Y TV E+
Sbjct: 3149 AKALDYELCQKHEMTISAIDGGWVAR-TGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENA 3207
Query: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303
GT V+ + A D NA I Y++ S ++ F ID TG + LD+E+ Y+L
Sbjct: 3208 PSGTTVIHLNATDADSGTNAVIAYTVQS-SDSDLFVIDPNTGVITTQGFLDFETKQSYHL 3266
Query: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDAD 3363
TV+A + ATVN+ + N+ P F Y ISE A V V A D D
Sbjct: 3267 TVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRD 3326
Query: 3364 GPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGS--PPRV 3421
++ +HY I ++ F I+ G++ V+ +LDRE +L V A + GS +
Sbjct: 3327 LGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADI 3386
Query: 3422 NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
+ TVN+ V D ND P+F+ YSV I E P+G V + D DS + F + I
Sbjct: 3387 DEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIG 3445
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
+GN+ AF +NPQ G + ++ + R+ Y L V D+G P + + + + + +
Sbjct: 3446 SGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDIND 3505
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV---YDTLTYSL--DPQMDNLFSVSST 3595
P + E + + + G ++ + +TD D+ TY L + FS+ ST
Sbjct: 3506 NGPMLTVSEGEVMEN--KRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-ST 3562
Query: 3596 GGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADI-TVHIRQVTQ 3636
G L +++D I + L+V D ++ TVHI + Q
Sbjct: 3563 AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQ 3607
Score = 1015 bits (2624), Expect = 0.0
Identities = 876/3028 (28%), Positives = 1412/3028 (46%), Gaps = 221/3028 (7%)
Query: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET 784
QV E QP G+ V + GF +L + F I+ TG L S +DRE+
Sbjct: 50 QVLEEQPPGTLV---GTIQTRPGFTYRL------SESHALFAINSSTGALYTTSTIDRES 100
Query: 785 TDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQV 844
+N+ V R+L V D NDN P F S V ED ++I
Sbjct: 101 LPSDVINLVVLSSAPTYPTEVRVL---VRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILD 157
Query: 845 EATDKDLGPNG--HVTYSIV--TDTDTFSIDSVTGVVNIAR--------PLDRELQHEHS 892
ATD D+G NG H +Y I+ + F +D LDRE+ ++
Sbjct: 158 TATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQ 217
Query: 893 LKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAH 952
L +E D+ EP+ + V V+++D+NDNPP F +Y+ V ED G+ ++ + A
Sbjct: 218 LLVEVEDKG--EPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAA 275
Query: 953 DPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSL 1012
D D G + +RY L D G F +D +G + + + LDFE ++ Y+LTV+A D+G P SL
Sbjct: 276 DADEGTNADIRYRLQDEGT-PFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP-SL 333
Query: 1013 SSTCYVEVEVVDVNENLHPPV-----FSSFVEKGTVKEDAPVGSLVMTVSAHDEDA-RRD 1066
+ ++++DVN+N PV F + +V E+A VG++V ++ D D+ +
Sbjct: 334 TGRAEALIQLLDVNDN--DPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAAN 391
Query: 1067 GEIRYSIRDGSGVGVFKIGE----ETGVIETSDRLDRESTSHYWLTVFATDQ-------G 1115
G I I G+ F++ +I+ + LDRE Y LTV +D
Sbjct: 392 GNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAA 451
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLM 1175
V SS + I V D+ND+ P S+ VY + E +P V I A D DS N L
Sbjct: 452 VQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLR 511
Query: 1176 YKITSGNPQGFFSIHPKTGLITT-TSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVK 1234
Y I SGN G+F I +GL+TT +S LDRE + +L ++ D G PK + A+++V
Sbjct: 512 YSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVT 571
Query: 1235 ILDENDNKPQFLQ-KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+LD ND KP F Q + Y + + E E L + ATD D G N + +S+++
Sbjct: 572 LLDVNDEKPVFSQPEGYDVSVVENAPTGTE-------LLMLRATDGDLGDNGTVRFSLQE 624
Query: 1294 G-NEHGKFFIEPKTG---VVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKP 1349
+ F ++P +G +SS Y +L + A D G P +SS R+++ +
Sbjct: 625 AETDRRSFRLDPVSGRLSTISSLDREEQAFYSLL-VLATDLGSPPQSSMARINVSLLDIN 683
Query: 1350 KPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI----PLWFDITGGNYDSHFDVD 1405
S P+ + +F + E++P I +S P + + + I+ G+ S F V+
Sbjct: 684 DNS--PVFYPVQYFAH-IKENEPGGSYITTVSATDPDLGTNGTVKYSISAGD-RSRFQVN 739
Query: 1406 KGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYE 1462
+G I LD E+K+ Y L + ATDG + V I V+DT D+ P FS Y
Sbjct: 740 AQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYS 799
Query: 1463 VVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDH 1522
V+ E+ A + +SA D + + Y + + F ++ TG L T+ +D
Sbjct: 800 FVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQK---GMFAINQVTGQLTTANVIDR 856
Query: 1523 EAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
E + L V+ V + + V D ND++P F + V E+ G +
Sbjct: 857 EEQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIF 913
Query: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642
Q A+D D+G N VLYS++ N N F I+ G+I LD + Y + + A+D
Sbjct: 914 QAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD-VHAGSYQIEILASDM 971
Query: 1643 GSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----V 1697
G P +S + ++V ++ SP F Y V LSE+ + S V A + S +
Sbjct: 972 GVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEI 1031
Query: 1698 VYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHL 1755
Y I +GNTGDAF I P G + + LD E Y L++ ++ A LS V V L
Sbjct: 1032 AYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVIL 1090
Query: 1756 QDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY--HIVE 1813
+D NDN P+F YT E S V + A D D N + Y +V+
Sbjct: 1091 EDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-------VSAVDKDFGPNGEVRYSFEMVQ 1143
Query: 1814 PSVHTYFAIDSSTGAIHTVLSLDYEE------TSIFHFTVQVHDMGTPRLFAEYAANVTV 1867
P F + + +G I D E T++F FTV D G P+ + A V V
Sbjct: 1144 PD----FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKD-QATVHV 1198
Query: 1868 HVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKF 1927
++ DIND P F K Y+A++ +V+ V+A+D D + YSI +GN +F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258
Query: 1928 SMDYKTGALTVQNTTQLRS--RYELTVRASDGRFAGLTS---VKINVKESKESHLKFTQD 1982
++D +G +T+ + Y L ++A D L S + I++ + ++ F +
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS 1318
Query: 1983 VYSAVVKENSTEAETLAVITAIGNPI--NEPLFYHI--LNPDRRFKISRTSGVLSTTGTP 2038
V EN E ++ +TA + N L+Y I N F IS +G +
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSI-FLAKK 1377
Query: 2039 FDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098
D E Q + + + ++ +P + + V + V D NDN P F + + + +G
Sbjct: 1378 LDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGT 1437
Query: 2099 VIRYVTAVDRDSGRNGEVHYYLKE---HHEHFQIGPL-GEISLKKQFELDTLNKEYLVTV 2154
+ VTA D D+ NG++ Y + + HF I + G I + + + N + +TV
Sbjct: 1438 SVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANL-FELTV 1496
Query: 2155 VAKDGGNPAFS-----AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP 2209
A D P + V + +T +N +P+F A ++ + S + + A P
Sbjct: 1497 KANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAV-IGSVLTTIMAADP 1555
Query: 2210 -EGL--KVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAE 2266
EG ++ Y I +GD F ++ +G + V + L + Y L + ATD L +
Sbjct: 1556 DEGANGEIEYEIINGDT-DTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATD-LGPERRK 1612
Query: 2267 VFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
++ + + PVF Q Y L E IGT+V+ + A S + Y +
Sbjct: 1613 STTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA-SPRGSEAPVEYYIVSVR 1671
Query: 2327 SKSHD---HFHVDSSTGLISLLRTLDYEQSR-QHTIFVRAVDGGMP---TLSSDVIVTVD 2379
+ F + TG+I LD EQ + + V A++ T ++V +T+
Sbjct: 1672 CEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQ 1731
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFV 2439
D+NDNPP+F + + + E+ G + + A DAD + Y+I+SG D F
Sbjct: 1732 --DINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FR 1788
Query: 2440 IDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEV 2499
ID +G + + + YSL + DG+ S ++++TV N H+P F + Y
Sbjct: 1789 IDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 2500 ELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-LDRET 2558
++ E+ +LV + TD DSG+ G +TY + D F++N +F L + LD E
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV 1908
Query: 2559 PAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKV 2618
+++VR A+D GG+ V + D NDN P F Y ++ + G++V+
Sbjct: 1909 QQYYILTVR--AEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVF 1966
Query: 2619 LASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVD- 2677
+DAD+G N+ +TY+I A +S+ + ++K +GV+ ++L F+ V+ D
Sbjct: 1967 NVTDADDGINSQLTYSI-ASGDSLGQ-FTVDK-NGVLKVLKALDRESQSFYNLVVQVHDL 2023
Query: 2678 -------NGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA--E 2728
S ++ S++L+ V PP PK + + E+ PI T + +A
Sbjct: 2024 PQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT------YIPENTPIDTVVFKAQATDP 2077
Query: 2729 HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHE 2788
SG Y P N+ F I G ++L LD E Y +++A +
Sbjct: 2078 DSGPNSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNYTLTVVA-TDKGQPS 2133
Query: 2789 MVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL 2848
+ +S +V + V D NDN+P+F + Y+ I EN G+ +IQ+ A+D D GTNGQV Y +
Sbjct: 2134 LSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGI 2193
Query: 2849 DQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908
+ + F I+ TG IT K LD EK Y + V A+D G + + T+ V + +
Sbjct: 2194 VNGNT---NQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-TDTSTVSIVL 2249
Query: 2909 TDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
D+ND P F Y V E+ + D N +++Y + GG+ F
Sbjct: 2250 LDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAF- 2308
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEK 3025
T+ ++ V + LDRE ++ ++L ITATD + + V V D NDN P
Sbjct: 2309 --TLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFAS 2366
Query: 3026 TLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPL 3085
Y TIPED G ++ ++A+DAD NA I ++G G +F +NP TG++ TS L
Sbjct: 2367 KAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIG-GNSQFTINPSTGQIITSALL 2423
Query: 3086 DREEQAVYHLLVRATDGGG---RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGT 3142
DRE + Y L+V +D G S+++T+ DVNDN P F PY + T PG+
Sbjct: 2424 DRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGS 2483
Query: 3143 LLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAV 3202
+ V TDAD G N ++ YSL +F I+ L G I PL+ + +++ +K
Sbjct: 2484 FVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK-- 2541
Query: 3203 DQG-LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA 3261
D G P+ T + TV V ++ D P V +E E+ V + V + +S E
Sbjct: 2542 DGGSFPK--TDSTTVTVRFVNKADFPKV-RAKEQTFMFPENQPVSSLVTTITGSSLRGE- 2597
Query: 3262 NAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATV 3321
++Y I SGN F ID TG V I + LD+E +Y + +EA DGG P S +
Sbjct: 2598 --PMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKL 2655
Query: 3322 NVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGS 3381
++ V D+NDN P+F +D + + I E+ + + ++TV A D D N + Y I++GN +
Sbjct: 2656 DITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNGNMEN 2714
Query: 3382 SFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFS 3441
SF+I+ GE++ + LDRE +S Y LT+++SD GSP + + V I++ D NDNAP FS
Sbjct: 2715 SFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFS 2774
Query: 3442 RGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTS 3500
+ +S + EN P+G++V ++ +DED N + + + F +NP G ++ S
Sbjct: 2775 Q-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM---DASLPFTINPSTGDIVIS 2830
Query: 3501 SAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYS 3560
+ R++ D Y ++V D+G + T + I V + + P ++
Sbjct: 2831 RPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEI 2887
Query: 3561 GGVIGKIHATDQDVYDT--LTYSLDPQMDNLFSVSSTGGKLI-----------AHKKLDI 3607
G + ++ ATD D + Y + Q + F +++T G++ ++I
Sbjct: 2888 GSKVTQVFATDPDEGSNGQVFYFIKSQSE-YFRINATTGEIFNKQILKYQNVTGFSNVNI 2946
Query: 3608 GQYLLNVSVTD-GKFTTVADITVHIRQV 3634
++ V+ +D GK + +++ TV I V
Sbjct: 2947 NRHSFIVTSSDRGKPSLISETTVTINIV 2974
Score = 860 bits (2222), Expect = 0.0
Identities = 840/2972 (28%), Positives = 1356/2972 (45%), Gaps = 295/2972 (9%)
Query: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
F L Y VT+ E+ + V+ + E+ Y I G++ + F G F
Sbjct: 996 FDQLSYEVTLSESEPVNSRF-FKVQASDKDSGANGEIAYTIAEGNTGDAF-------GIF 1047
Query: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPT 152
++ K L+RE++D Y L+V A ++ + A V V + D ND RPLF+ T
Sbjct: 1048 PDGQLYIKSE----LDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNST 1103
Query: 153 SYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDY 212
+Y+ E + + +VSA D D G NGE YSF+ F +H SG I T + D
Sbjct: 1104 NYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDR 1163
Query: 213 LE------TKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVIT----AVTL 262
T ++ ++A D+G+ + A + V+++ N+ AP T+
Sbjct: 1164 ESLMRRRGTAVFSFTVIATDQGI----PQPLKDQATVHVYMKDINDNAPKFLKDFYQATI 1219
Query: 263 SPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGG 322
S S + V+ D D+G NG + SI+ G+ +QF S +V IG
Sbjct: 1220 SESAANLTQVLR-VSASDVDEGNNG-LIHYSIIKGNEERQFAI-----DSTSGQVTLIGK 1272
Query: 323 IDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPP 382
+D+++ P Y+L +QA D GT P +S +++ F K ++ E
Sbjct: 1273 LDYEATP-AYSLVIQAVDSGTIP-LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRI 1330
Query: 383 NTPVVMVKAIPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEV 438
V V A + S L Y T FS++ NTG I + + + + + ++L +
Sbjct: 1331 GELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNI 1390
Query: 439 TTSD-----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEG 493
T D R ++ V++ V N NPP F + EN+PIGT+V+S++A DPD
Sbjct: 1391 TAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450
Query: 494 ENGYVTYSIANL----NHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY-- 547
NG ++Y+I NH F ID G + T+ +D E ++ L ++A+D +P
Sbjct: 1451 INGQLSYTIIQQMPRGNH--FTIDEVKGTIYTNAEIDRE-FANLFELTVKANDQAVPIET 1507
Query: 548 RREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQ 605
RR TI + +LNDN P+F N P + +G +TT+ A D DE ++Y+
Sbjct: 1508 RRYALKNVTILVTDLNDNVPMFISQNALAADPSAV-IGSVLTTIMAADPDEGANGEIEYE 1566
Query: 606 IEAGNELDFFSLNPNSGVLSLKRSLMDG------------LGAKVSFHSLRIT----ATD 649
I G + D F ++ SG L + +L+ LG + + +T D
Sbjct: 1567 IING-DTDTFIVDRYSGDLRVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLD 1625
Query: 650 GENFATPLYINI----------------------TVAASHKLVNLQCEETGVAKMLA--- 684
G F P YI I + +V+++CEE V ++
Sbjct: 1626 GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGR 1685
Query: 685 -EKLLQANKL--HNQG--------------------EVEDIFFDSHSVNAHIPQFRSTLP 721
++Q + QG + ++ +N + P F + +
Sbjct: 1686 HTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM- 1744
Query: 722 TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLD 781
+ V+EN GS ++ + + D D G N + Y + G +DS F ID E+G L LD
Sbjct: 1745 LDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLD 1803
Query: 782 RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841
RE KY+L + D G+ Q + R +++ V D ND+ P+F + Y ++ ED S +
Sbjct: 1804 RERRSKYSLLVRADD-GL-QSSDMR-INITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLV 1860
Query: 842 IQVEATDKDLGPNGHVTYSIVTDTD--TFSIDSVTGVVNIARPLDRELQHEHSLKIEARD 899
+ ATD D G NG +TY + D + F ++ +TGV N+ R LD E+Q + L + A D
Sbjct: 1861 AAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAED 1920
Query: 900 QAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQS 959
+ F+T+ V ++ DVNDNPP F +Y + E+LP G+ ++ D D G +
Sbjct: 1921 GGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGIN 1976
Query: 960 GQVRYSLLDHGE-GNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGK-PVS-LSSTC 1016
Q+ YS+ G F VDK +G +++++ LD E + YNL V+ D + P S +ST
Sbjct: 1977 SQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTA 2035
Query: 1017 YVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDG 1076
V + ++DVN+N PP F S + + E+ P+ ++V A D D+ + I Y++ +
Sbjct: 2036 QVSIILLDVNDN--PPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNP 2092
Query: 1077 SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNA 1136
G F IG G + + LDRE S+Y LTV ATD+G LSS E+ + V D+NDN
Sbjct: 2093 LG-NKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN 2151
Query: 1137 PQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLI 1196
P ++ +Y EI EN+ ++Q+ A D D +N ++ Y I +GN F I TG I
Sbjct: 2152 PIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAI 2211
Query: 1197 TTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPE 1256
T ++ LDRE+ + L V TD GS P++ + V + +LD ND P F Y + +PE
Sbjct: 2212 -TVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPE 2270
Query: 1257 REKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP--KTGVVSSKRF 1314
+ V+A D D G N+++SY + GNE F + + GV S
Sbjct: 2271 ------NLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDR 2324
Query: 1315 SAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVA 1374
+ +L I A D+G P + T +++ I P +++FT T+ E P
Sbjct: 2325 ETKERF-VLMITATDSGSPALTGTGTINV--IVDDVNDNVPTFASKAYFT-TIPEDAPTG 2380
Query: 1375 HMIGVISVEPPGIP--LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEAT 1432
+ +++ I GGN S F ++ TG II + LD E K NY L V +
Sbjct: 2381 TDVLLVNASDADASKNAVIRIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCS 2438
Query: 1433 DGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EK 1486
D + + T V + V D ND+ P+F Y IP T P + + ++ D D
Sbjct: 2439 DAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPN 2498
Query: 1487 NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFA 1546
++L Y+L +KF +DP G++ + L+ + T +V V+D K +
Sbjct: 2499 SELHYSLSGRNS----EKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSFPKTDST 2552
Query: 1547 RIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
+ V + D P A E+ V S+V +T + + Y I SGN+
Sbjct: 2553 TVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITG---SSLRGEPMSYYIASGNL 2608
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
GN+F ID + G + ++ LD +Y + ++A D G PP S + I V ++ +P
Sbjct: 2609 GNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPI 2668
Query: 1667 FTSKEYSVELSETVSIGSFVGMVTAHSQS----SVVYEIKDGNTGDAFDINPHSGTIITQ 1722
F + E+ E +S + + S + YEI +GN ++F IN +G I +
Sbjct: 2669 FKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSV 2728
Query: 1723 KALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASI 1780
+ LD E + Y L I+ ++ ST+ V++++ DENDNAP F Q ++ + E++ +
Sbjct: 2729 RPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPL 2787
Query: 1781 NSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEET 1840
V + +D D NA+ Y I++ S+ F I+ STG I L+ E+T
Sbjct: 2788 GYTVTR-------VTTSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNREDT 2838
Query: 1841 SIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT 1900
+ V HD G + +VT+ V DIND P F++ Y T G KV
Sbjct: 2839 DRYRIRVSAHDSGW-----TVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQ 2893
Query: 1901 VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTG------ALTVQNTTQLR----SRYEL 1950
V ATD D + Q+ Y I + E F ++ TG L QN T +R+
Sbjct: 2894 VFATDPDEGSNGQVFYFIKSQS--EYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSF 2951
Query: 1951 TVRASDGRFAGL---TSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
V +SD L T+V IN+ +S ++ +F + Y V +N L +TAI +
Sbjct: 2952 IVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDK 3011
Query: 2008 ---INEPLFYHILNPDR--RFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAV 2062
+N + Y I N + +FK+ +G +S + Q F + V ++ P
Sbjct: 3012 DFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFF-ITVTAKDKGNPPLS 3070
Query: 2063 AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKE 2122
+ V + V ++N + P F A + +G ++R V+A DRD+ NG + Y +
Sbjct: 3071 SQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISS 3130
Query: 2123 HHEH--FQI-GPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNK 2177
+E F I G ++L K + + L +++ +T+ A DGG A + V + V +N
Sbjct: 3131 GNEEGIFAINSSTGILTLAKALDYE-LCQKHEMTISAIDGGWVARTGYCSVTVNVIDVND 3189
Query: 2178 AMPVFEKPFYSAEIAESIQVHSPVVHV---QANSPEGLKVFYSITDGDPFSQFTINFNTG 2234
PVF Y + E+ + V+H+ A+S + Y++ D F I+ NTG
Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS-DLFVIDPNTG 3248
Query: 2235 VINVIAPLDFEAHPAYKLSIRATDSLTGAHAE-VFVDIIVDDINDNPPVFAQQSYAVTLS 2293
VI LDFE +Y L+++A + V+I + N+ P F + Y +S
Sbjct: 3249 VITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEIS 3308
Query: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
EA+ GT V +V A+D D + + Y +FGN K F ++ TG I + LD E+
Sbjct: 3309 EAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKK--GFQINKKTGQIYVSGILDREKE 3366
Query: 2354 RQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDN-PPLFEQQIYEARISEHAPHGHFVTCV 2412
+ ++ V A + G + VTV+VT L+ N PP+F IY +ISE P G VT V
Sbjct: 3367 ERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFV 3426
Query: 2413 KAYDADS-SDIDKLQYSILSGNDHKHFVIDSATGIITL-SNLHRHALKPFYSLNLSVSDG 2470
A+D+DS + Y I SGN++ F I+ TG IT+ + L R L P Y+L++ D
Sbjct: 3427 SAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETL-PIYNLSVLAVDS 3485
Query: 2471 VFRSST---QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD-SGIYGH 2526
S+T + VT+ N + P +E EV EN TLVM +++TD D G
Sbjct: 3486 GTPSATGSASLLVTLEDINDNGPMLTVSEGEV--MENKRPGTLVMTLQSTDPDLPPNQGP 3543
Query: 2527 VTYHIVNDF-AKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAG--GKVAFCTVN 2583
TY++++ A F ++ G + T ++DRE A+ +SV + KD+G + TV+
Sbjct: 3544 FTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSV--VTKDSGVPQMSSTGTVH 3601
Query: 2584 VILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDAD--EGSNADITYAI------ 2635
+ + D NDN Q R + VN + G + V D D + + +T +
Sbjct: 3602 ITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCSLTSGVTSLFSI 3661
Query: 2636 -------EADSESVKENLEINKLS--GVITTKESLIGLENEFFTFFVRA-VDNGSPSKES 2685
+ S ++ LS GV +T S I + FF F A VDN
Sbjct: 3662 PGGTCDLNSQPRSTDGTFDLTVLSNDGVHSTVTSNIRV---FFAGFSNATVDNS------ 3712
Query: 2686 VVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA--EHSGTVLYSLVKGNTP 2743
+L+ + + + L F S+ +GT + L A E++ T L + VK N
Sbjct: 3713 -ILLRLGVPTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYSAYEENNRTFLLAAVKRNHN 3771
Query: 2744 ESNRDESF---------VIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVD 2794
+ ++ RQSG +K+E S+DH+ S + Q+ + +
Sbjct: 3772 QYVNPSGVATFFESIKEILLRQSG-VKVE-SVDHD-------SCVHGPCQNGGSCLRRLA 3822
Query: 2795 VSIQVKDANDNSPVF--ESSPYEAFIVENLPG 2824
VS +K + ++ PV + P + F+ + LPG
Sbjct: 3823 VSSVLK-SRESLPVIIVANEPLQPFLCKCLPG 3853
Score = 774 bits (1999), Expect = 0.0
Identities = 674/2381 (28%), Positives = 1121/2381 (47%), Gaps = 170/2381 (7%)
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDS 1400
L + W+ P + E F V+E P ++G I P T +S
Sbjct: 25 LRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRP-------GFTYRLSES 77
Query: 1401 H--FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFST 1458
H F ++ TG + +D E + + + T T+V + V D ND+ P F
Sbjct: 78 HALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPD 137
Query: 1459 SKYEVVIPEDTAPETEILQISAVDQD-EKNKLIYTLQSSRDPLSLKKFRLD--------P 1509
V ED++ +++ +A D D N + + +FRLD
Sbjct: 138 PSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEG 197
Query: 1510 ATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG 1569
A L + LD E Q+ L V V D+ P +R + ++ V V D ND+ P F +S Y+
Sbjct: 198 AFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQA 257
Query: 1570 RVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSN 1629
V E A VGS VLQV A D D+G NA++ Y ++ + G F +DP G I + LD
Sbjct: 258 GVPEDAVVGSSVLQVAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVREPLDFEA 315
Query: 1630 QAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASP--KF-----TSKEYSVELSETVSI 1682
+ +Y L V+A D+G P ++ I + ++ P KF TS+ SV+ E +
Sbjct: 316 RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVD--ENAQV 373
Query: 1683 GSFVGMVTAHSQSS------VVYEIKDGNTGDAFDIN----PHSGTIITQKALDFETLPI 1732
G+ V ++T S + +I GN F++ P+ I ALD E +P
Sbjct: 374 GTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPS 433
Query: 1733 YTLIIQ---------GTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSV 1783
Y L + G + S+ ++++ + D ND+ PVF Q Y +SE A S
Sbjct: 434 YNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSY 493
Query: 1784 VLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS--LDYEETS 1841
V I A D D NA L Y IV + +F I +G + T S LD E S
Sbjct: 494 VSG-------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELAS 546
Query: 1842 IFHFTVQVHDMGT-PRLFAEYAANVTVHVIDINDCPPVFAKPL-YEASLLLPTYKGVKVI 1899
+ D G P++ A + V ++D+ND PVF++P Y+ S++ G +++
Sbjct: 547 QIVLNISARDQGVHPKV---SYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELL 603
Query: 1900 TVNATDADSSAFSQLIYSITEGNIGEK-FSMDYKTGALTVQNTTQLRSR--YELTVRASD 1956
+ ATD D + +S+ E + F +D +G L+ ++ + Y L V A+D
Sbjct: 604 MLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATD 663
Query: 1957 ---GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI--NEP 2011
+ + + +++ + ++ F Y A +KEN + ++A + N
Sbjct: 664 LGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGT 723
Query: 2012 LFYHILNPDR-RFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVI 2070
+ Y I DR RF+++ SGV+ST DRE++ A+ + + T+ + +V +
Sbjct: 724 VKYSISAGDRSRFQVNAQSGVISTR-MALDREEKTAYQLQIVATDGGNLQSPNQAIVTIT 782
Query: 2071 VEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG 2130
V D DN PVF + Y VV + +G+ + V+A D N + F I
Sbjct: 783 VLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAIN 842
Query: 2131 PL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSA 2189
+ G+++ +D + + V GG V + + +N P F + S
Sbjct: 843 QVTGQLTTAN--VIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESV 900
Query: 2190 EIAESIQVHSPVVHVQANSP-EGLK--VFYSITDGDPFSQFTINFNTGVINVIAPLDFEA 2246
+ E+ Q + +A P EG+ V YS+ +P + F IN G I+++ PLD A
Sbjct: 901 NVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLDVHA 959
Query: 2247 HPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQV 2305
+Y++ I A+D + + V + + V D+NDN PVF Q SY VTLSE+ + + +V
Sbjct: 960 -GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKV 1018
Query: 2306 RATDSDSEPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVD 2364
+A+D DS N I+Y + GN + F G + + LD E ++ + V A D
Sbjct: 1019 QASDKDSGANGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDRYVLMVVASD 1074
Query: 2365 GGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDK 2424
+ LS+ V VTV + D+NDN PLF Y E G FV V A D D +
Sbjct: 1075 RAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGE 1134
Query: 2425 LQYSILSGNDHKHFVIDSATGIITLSN-------LHRHALKPFYSLNLSVSDGV---FRS 2474
++YS F + + +G IT ++ + R F ++ G+ +
Sbjct: 1135 VRYSF--EMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKD 1192
Query: 2475 STQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVND 2534
VHV + N ++P FL++ Y+ ++E+A T V+ V +D D G G + Y I+
Sbjct: 1193 QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKG 1252
Query: 2535 FAKDRFYINE-RGQIFTLEKLDRE-TPAEKVISVRLMAKDAG--GKVAFCTVNVILTDDN 2590
+ +F I+ GQ+ + KLD E TPA ++ + A D+G + CT+N+ + D+N
Sbjct: 1253 NEERQFAIDSTSGQVTLIGKLDYEATPAYSLV---IQAVDSGTIPLNSTCTLNIDILDEN 1309
Query: 2591 DNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINK 2650
DN P F + V++ + G V V A+D+D G NAD+ Y+I + I+
Sbjct: 1310 DNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNN--HGTFSISP 1367
Query: 2651 LSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTF 2710
+G I + L + + A D G P + S + V + + P F
Sbjct: 1368 NTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFK 1427
Query: 2711 TVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS 2765
++ E++PIGT + + A+ +G + Y++++ + R F ID G +
Sbjct: 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQ----QMPRGNHFTIDEVKGTIYTNAE 1483
Query: 2766 LDHETTKWYQFSILA--RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823
+D E ++ ++ A + + A +V+I V D NDN P+F S A +
Sbjct: 1484 IDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALA-ADPSAV 1542
Query: 2824 GGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNY 2883
GS + I A+D D G NG++ Y + + ++F ++ +G + L + Y
Sbjct: 1543 IGSVLTTIMAADPDEGANGEIEYEIINGDT----DTFIVDRYSGDLRVASALVPSQL-IY 1597
Query: 2884 QIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG-GVIAILST 2942
+ V A+D G + + S+T ++T+ P FT Y + E +P G VI+I +
Sbjct: 1598 NLIVSATDLGPERRKSTT---ELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA 1654
Query: 2943 TDADSEEINRQVTYFITG----GDPLGQ-FAVETIQNEWKVYVKKPLDREK-RDNYLLTI 2996
+ SE V Y+I +G+ F + ++ + LDRE+ YL+ +
Sbjct: 1655 SPRGSE---APVEYYIVSVRCEEKTVGRLFTIG--RHTGIIQTAAILDREQGACLYLVDV 1709
Query: 2997 TATDGTF----SSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADI 3052
A + + + +A VE+ + D NDN PV + T+ E++ G IMQ++A DAD
Sbjct: 1710 YAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADE 1769
Query: 3053 RSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIV 3112
+NA +TYT++ + F+++P++G+L + LDRE ++ Y LLVRA D G + I
Sbjct: 1770 GANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRIN 1828
Query: 3113 LTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL-IDSADGQ 3171
+T+ DVND+ P+FS Y+ + E+T PG+L+ + ATD D+G+N +I Y + D DG
Sbjct: 1829 ITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGI 1888
Query: 3172 FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFE 3231
F +N ++G+ L + LD E+Q Y L+++A D G T V ++LD+NDNPP+F
Sbjct: 1889 FFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG---GQFTTIRVYFNILDVNDNPPIFS 1945
Query: 3232 YREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIE 3291
Y ++ E++ VG+ VL D N+++TYSI SG+ G+F++D K G + +++
Sbjct: 1946 LNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLK 2004
Query: 3292 NLDYESSHEYYLTVEATDGGTPSL-----SDVATVNVNVTDINDNTPVFSQDTYTTVISE 3346
LD ES Y L V+ D P + + A V++ + D+NDN P F T I E
Sbjct: 2005 ALDRESQSFYNLVVQVHD--LPQIPASRFTSTAQVSIILLDVNDNPPTFLSPK-LTYIPE 2061
Query: 3347 DAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGY 3406
+ ++ V A D D NS+I Y++++ G+ F+I + GEV++T LDRE +S Y
Sbjct: 2062 NTPIDTVVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNY 2120
Query: 3407 TLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTD 3466
TLTV A+D G P ++T V + V D+NDN P+F++ Y V I EN G ++Q+ D
Sbjct: 2121 TLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAAD 2180
Query: 3467 EDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKPQL 3525
D NG + IV GN + F ++ G + + + R++ Y L V+ D G
Sbjct: 2181 GDEGTNG-QVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR 2239
Query: 3526 SSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYS--GGVIGKIHATDQD--VYDTLTYS 3581
+ + + I +++ + + P + L + + E I ++ A D D L+Y
Sbjct: 2240 TDTSTVSIVLLDINDFVP-VFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYV 2298
Query: 3582 L-DPQMDNLFSVSSTGGKLIAHKKLD---IGQYLLNVSVTD 3618
L DN F++S++ G+L + LD +++L ++ TD
Sbjct: 2299 LFGGNEDNAFTLSAS-GELGVTQSLDRETKERFVLMITATD 2338
Score = 124 bits (311), Expect = 2e-27
Identities = 59/171 (34%), Positives = 80/171 (46%), Gaps = 22/171 (12%)
Query: 4015 EDCASNPCQNGGVC---------------------NPSPAGGYYCKCSALYIGTHCEISV 4053
+ C PCQNGG C P + CKC Y G+ CEI +
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 4054 NPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAV 4112
+ C PC GGTC GGF C C +TG+ C+ C PCKNG C +
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFN 3923
Query: 4113 CQCDSGFRGERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
C C +G+ G+ C+S ++ C NPC +G C++ SY+C+C G+HCE
Sbjct: 3924 CVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 110 bits (275), Expect = 3e-23
Identities = 92/362 (25%), Positives = 152/362 (41%), Gaps = 54/362 (14%)
Query: 3786 RCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ-CPGS----SSMTLTGNSYV 3840
+CP + C PC G C+ D W + C C G G+ C S ++++L G +
Sbjct: 4158 QCPRLEGACTRSPCQHGGTCM-DYWSWQQ-CHCKEGLTGKYCEKSVTPDTALSLEGKGRL 4215
Query: 3841 KYRLTENENKLEM----------------KLTMRLRTYSTHAVVMYAR-GTDYSILEIHH 3883
Y +++NE + + L ++ RT S + V+++ + ++Y+ ++I +
Sbjct: 4216 DYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKN 4275
Query: 3884 GRLQYKFDCG-SGPGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAP---- 3938
G++ + D G +G ++ + V DG WH + NG L +D+++ P
Sbjct: 4276 GKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDF 4335
Query: 3939 GTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAH 3998
G L L + GG Q R ++ GF GC+ S++ G+ LP + K +
Sbjct: 4336 GGLDVLTIS----LGGIPPNQAHRDAQTA----GFDGCIASMWYGGESLPFSGKHSLASI 4387
Query: 3999 IEESVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSS 4058
+ V GC CASNPC +C Y +C + C+S
Sbjct: 4388 SKTDPSVKIGC--RGPNICASNPCWGDLLCINQ---WYAYRC----------VPPGDCAS 4432
Query: 4059 KPCLYGGTCVVD-NGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTC-FDSLDGAVCQCD 4116
PC GG+C + GF C C +TG+ C++ C C G C S G VC
Sbjct: 4433 HPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAGHVCVLS 4492
Query: 4117 SG 4118
G
Sbjct: 4493 QG 4494
Score = 81.3 bits (199), Expect = 2e-14
Identities = 80/296 (27%), Positives = 121/296 (40%), Gaps = 36/296 (12%)
Query: 3780 CLCKEG----RCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLT 3835
C+CK G C + CE +PC G C S + + C CP G FG+ +S
Sbjct: 3924 CVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGV--DSYYCHCPFGVFGKHCELNSYGFE 3981
Query: 3836 GNSYVKY-RLTENENKLEMKLTMRLRTYSTHAVVMY------ARGTDYSILEIHHGRLQY 3888
SY+++ L N N + +K T +HA+++Y ++ LEI RL++
Sbjct: 3982 ELSYMEFPSLDPNNNYIYVKFA----TIKSHALLLYNYDNQTGDRAEFLALEIAEERLRF 4037
Query: 3889 KFDCGSGPGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVH--------TASGTAPGT 3940
++ GSG ++ +V+DG +H V G A L +D T S A
Sbjct: 4038 SYNLGSGTYKLTTMK-KVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSD 4096
Query: 3941 LKTLNLD-NYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHI 3999
TL++ N V GG + R + F GC+ +NG+ L +P
Sbjct: 4097 DWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPL----EPSQALAA 4152
Query: 4000 EESVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP 4055
+ +D P C +PCQ+GG C C C G +CE SV P
Sbjct: 4153 QGILDQCP----RLEGACTRSPCQHGGTC-MDYWSWQQCHCKEGLTGKYCEKSVTP 4203
Score = 68.9 bits (167), Expect = 1e-10
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 4016 DCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFV 4075
+C +PC+NG +C P G + C C Y G CE SVN C PC GG+C +
Sbjct: 3903 ECLQSPCKNGAICQNFP-GSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYY 3961
Query: 4076 CQCRGLYTGQRCQLSPYCKDE 4096
C C G+ C+L+ Y +E
Sbjct: 3962 CHCPFGVFGKHCELNSYGFEE 3982
Score = 38.9 bits (89), Expect = 0.12
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 4088 QLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDI 4128
+L C PC++GGTC D C C G G+ C+ +
Sbjct: 4161 RLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSV 4201
Score = 37.4 bits (85), Expect = 0.35
Identities = 19/67 (28%), Positives = 29/67 (43%), Gaps = 2/67 (2%)
Query: 4098 CKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCE-NTHGSYHCNCSHE 4156
C+ C + C + + RC D C+ +PC +G CE H + C+C
Sbjct: 4398 CRGPNICASNPCWGDLLCINQWYAYRCVPPGD-CASHPCQNGGSCEPGLHSGFTCSCPDS 4456
Query: 4157 YRGRHCE 4163
+ GR CE
Sbjct: 4457 HTGRTCE 4463
Score = 33.9 bits (76), Expect = 3.8
Identities = 12/42 (28%), Positives = 20/42 (47%)
Query: 4122 ERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
++C C+ +PC HG C + C+C G++CE
Sbjct: 4157 DQCPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 922 bits (2383), Expect = 0.0
Identities = 837/2881 (29%), Positives = 1308/2881 (45%), Gaps = 214/2881 (7%)
Query: 724 IQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS---GGNEDSCFMIDMETGMLKILSPL 780
+Q+ E QP G+ +I S L G L+Y +S G + ID +G+++ L
Sbjct: 49 LQIDEEQPAGT-LIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
Query: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
DRE D+Y D A + V V D ND+ P F Q ++V E +
Sbjct: 108 DREQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTR 161
Query: 841 IIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARP-------LDRELQHEH 891
A D D G G Y++ D +TF +++ G P LDRE + +
Sbjct: 162 YPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
Query: 892 SLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEA 951
L++EA D P + ++ V+L D+ND+ P F Y V E L G+ ++ + A
Sbjct: 222 MLQLEAYDGG--SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFA 279
Query: 952 HDPDLGQSGQVRYSL---LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGK 1008
D D G +G V Y + G+G F +D +G +++ + LDFE+++V+ L V+A+D G
Sbjct: 280 SDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGA 339
Query: 1009 PVSLSSTCYVEVEVVDVNEN--LHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRD 1066
L S +V V V D N+N +F S V E AP G LV +S D D
Sbjct: 340 HPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF 398
Query: 1067 GEIRYSIRDGSGVGVFKIGEETGVIE---TSDRLDRESTSHYWLTVFATDQGVVPLSSFI 1123
+ S+ G G F + + VI + RLDRE Y L V ATD G PL +
Sbjct: 399 AHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEA 456
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPE-IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGN 1182
+ V DVNDNAP +Y PE + E + VV++ A DPD +N ++ Y + G
Sbjct: 457 AFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGA 516
Query: 1183 PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
+FSI P +G+ITT + LD E + + L V TD G PP ++ A V V + D NDN+
Sbjct: 517 HTHWFSIDPTSGIITTAA-SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNE 575
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDG---NEHGK 1299
PQF + FY LPE +P V ATD D GP +SYS+ G +
Sbjct: 576 PQFQRTFYNASLPEGTQPG-------TCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
Query: 1300 FFIEPKTGVVSSKRF----SAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F I+ +G V + R +D ++ AVD G + ++ + + P P
Sbjct: 629 FRIDAHSGDVCTTRTLDRDQGPSSFD-FTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYP 687
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIP---LWFDITGGNYDSHFDVDKGTGTII 1412
+ S +S P ++ + + +P L + I GN F +D+ +G +
Sbjct: 688 REYAASISA----QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Query: 1413 VAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDT 1469
VA PL S L + A DG +V I ++ P F +Y +PED
Sbjct: 744 VAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDV 803
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
AP T + + A + + + S DP L F LD +G L T LD E +
Sbjct: 804 APGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGL--FSLDAVSGLLQTLRPLDRELLGPVL 861
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
+ VP AR+ V + D ND++P F A + + A G+ + + ALD
Sbjct: 862 ELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDP 921
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N+ V +++ +G G +F +DP G ++ + L S ++L ++A D GSPP +
Sbjct: 922 DSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTS 980
Query: 1650 ITSVRIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS--VVYEIKDGN 1705
+R+ V +P+F S Y V+L + G+ V V A + + Y +
Sbjct: 981 HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEG 1040
Query: 1706 TGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA----GLSTNT-TVLVHLQDEND 1760
F + P SG + + ALD E +Y L + + + G T T TV V + ++N+
Sbjct: 1041 ASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
Query: 1761 NAPVFMQAEYTGLISES----ASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV 1816
++P + ++E+ S+ V TDR D N L Y + + S
Sbjct: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDR-----------DSGPNGRLTYSLQQLSE 1149
Query: 1817 HT-YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDC 1875
+ F I TG + T+ +LD E+ S + VQV D G+P V V V+D+ND
Sbjct: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPP--RSTTGTVHVAVLDLNDN 1207
Query: 1876 PPVFAKPLYEASLLLPTY------KGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929
P F + A LP G V T+ A D D ++Y++T G E FS+
Sbjct: 1208 SPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSL 1266
Query: 1930 DYKTGAL--TVQNTTQLRSRYELTVRASD-GRFAGLTSVKINVKESKESHLK------FT 1980
+G L R Y LT+ A D G S+++ V+ + L
Sbjct: 1267 HPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAE 1326
Query: 1981 QDVYSAV-VKENSTEAETLAVITAIGN-PINEP-----LFYHIL---NPDRRFKISRTSG 2030
+D + V V T AE L + +G+ EP L Y ++ +P+ F + SG
Sbjct: 1327 RDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASG 1386
Query: 2031 VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVV 2090
L P D E + + E + + V+V V+D+N++AP F P +
Sbjct: 1387 RL-YLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALAL 1445
Query: 2091 KVDTEVGHVIRYVTAVDRDS-GRNGEVHYYLKEHHEHFQIGPL----GEISLKKQFELDT 2145
+ E G + A D D G N +V Y L L G +S + + +T
Sbjct: 1446 PENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET 1505
Query: 2146 LNKEYLVTVVAKD-----GGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP 2200
L+ V A D A V +T N PVF P + E
Sbjct: 1506 -TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASP-SRVRLPEDQPPGPA 1563
Query: 2201 VVHVQANSP---EGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT 2257
+HV A P E +V Y + G F ++ +TG ++V+ PLD E + L++ A+
Sbjct: 1564 ALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTVVAS 1622
Query: 2258 D-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNR 2316
D A + + V D+ND P F QQ Y+V L E + GTS++ +RATD D N
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
Query: 2317 GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
++Y S + F +D TG+++ LR LD E+ + + V A D G P + V V
Sbjct: 1683 QVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
Query: 2377 TVDVTDLNDNPPLFEQQIYEARISEHAPHG---HFVTCVKAYDADSSDIDKLQYSILSGN 2433
V V D ND+ P F A +S P G +T ++A D D +LQY IL G+
Sbjct: 1738 RVAVEDENDHAPTFG----SAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGD 1793
Query: 2434 DHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLHS 2489
FV+D A+G T+ L R ++P + L + DG ++ + VTV+ N H+
Sbjct: 1794 PSGAFVLDLASGEFGTMRPLDRE-VEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHA 1852
Query: 2490 PAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIF 2549
PAF Y VE+ E+ P TL+++++ D D+G GHVTY++ A G++
Sbjct: 1853 PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELR 1912
Query: 2550 TLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILT--DDNDNAPQFRATKYEVNI-- 2605
T LDRE SV + A G ++ TV+V +T D ND+AP F + + +
Sbjct: 1913 TAAALDREQCPSYTFSVSAVDGAAAGPLS-TTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
Query: 2606 -GSSAAKGTSVVKVL-ASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIG 2663
G S + T + L A D D G+NA I Y + + + ++ +G I S +
Sbjct: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRL---AGTPPPGTTVDSYTGEIRVARSPVA 2028
Query: 2664 LENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEID 2723
L F+ A D G P++ + ++ V + + P+F T+ E+ P GT I
Sbjct: 2029 LGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
Query: 2724 LIRAEH----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE--KSLDHETTKWYQFS 2777
RA H +G + YS++ G N +F I +G + + + LD E + +
Sbjct: 2089 SPRAVHAGGTNGPITYSILSG-----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLV 2143
Query: 2778 ILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDAD 2837
+ A + A +++ ++DANDN+P F Y AF+ E+ P ++Q+ A D D
Sbjct: 2144 LQA----ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199
Query: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
G+ GQ+ YSL SQ + F ++ TG ITT LD E ++ ++A+D G
Sbjct: 2200 QGSGGQISYSLAASQPARGL--FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-A 2256
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYF 2957
L +A + V V D ND+ P + ++ VSED G IA ++ D DS + + Y
Sbjct: 2257 LVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSGPV---LWYV 2312
Query: 2958 ITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDAN 3017
++ P F+V +V + PLD E+ D Y L + A DG +A + V V D N
Sbjct: 2313 LSPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVN 2370
Query: 3018 DNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTG 3077
DN+P ++LY + E PG I+ +SATD D +N I+Y L S A+ F ++P+ G
Sbjct: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYH-LASPADGFSVDPNNG 2429
Query: 3078 ELKT---STPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAI 3132
L T + L + +++ A D G GR +A++ + L+D ND+AP F+ Y +
Sbjct: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489
Query: 3133 TVFENTEPGTLLTRVQATDADAGLNRKIL-YSLIDSADGQ-FSIN--------------E 3176
V E+ PG+ L ++ATDAD + + YS+I G+ F +
Sbjct: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPR 2549
Query: 3177 LSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYG 3236
G + L +PLD E Y L++ A D+G P + ++ V V+VLD+NDNPPVF Y
Sbjct: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQ-SSVVPVTVTVLDVNDNPPVFTRASYR 2608
Query: 3237 ATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYE 3296
TV ED VG E+L V A+ D + + +++ SG+ G F +D +G + + LD E
Sbjct: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCE 2668
Query: 3297 SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVIT 3356
+ + L V+A D + +A V + V D+ND+ P F + +T ++E+ V T
Sbjct: 2669 TQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT 2727
Query: 3357 VMADDADGPSNSHIHYSIIDGNQG----SSFTIDPVRGEVKVTKLLDRETISGYTLTVQA 3412
+ A D D + + YS+++ G +F ++ GE++ D E + L V A
Sbjct: 2728 LHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGA 2787
Query: 3413 SDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHN 3472
+D G+ + TV++ V+ ++ PVF + + E G S+ + TDED +
Sbjct: 2788 ADAGNLSA--SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGAD 2845
Query: 3473 G 3473
G
Sbjct: 2846 G 2846
Score = 810 bits (2093), Expect = 0.0
Identities = 774/2796 (27%), Positives = 1236/2796 (44%), Gaps = 209/2796 (7%)
Query: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
+N H P F +QV E+ G+ + D D G G YA+SG F ++
Sbjct: 136 INDHAPAFPQAR-AALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
Query: 769 METGM-------LKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPE 821
G L + LDRE Y L + YD G P + A LL V ++D ND+ P
Sbjct: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
Query: 822 FLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI----VTDTDTFSIDSVTGVV 877
F Q Y VSE S ++QV A+D D G NG VTY I FSID+ TG++
Sbjct: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
Query: 878 NIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT----FIPPNYR 933
+ RPLD E + H L ++ARD P+L S V V + D NDN P+ F+ +
Sbjct: 315 QLERPLDFEQRRVHELVVQARDGGAH-PELGSAFVT-VHVRDANDNQPSMTVIFLSADGS 372
Query: 934 VKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDV---DKLSGAVRIVQQLD 990
+V E P G ++ + DPD G V SL + GEG+F + D + V + ++LD
Sbjct: 373 PQVSEAAPPGQLVARISVSDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLD 431
Query: 991 FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
E++ YNL V A D G P + +V + V DVN+N P + E A G
Sbjct: 432 REERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNA-PAFDRQLYRPEPLPEVALPG 489
Query: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVF 1110
S V+ V+A D D +G++ YS+ G+ F I +G+I T+ LD E L V
Sbjct: 490 SFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
Query: 1111 ATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS 1170
ATD G+ PL+S + + ++DVNDN PQ Y + E + +Q+ A D DS
Sbjct: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
Query: 1171 NDKLMYKI-----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI-LEVTVTDNGSPP 1224
L Y + +SG+P F I +G + TT R LDR+Q VT D G
Sbjct: 610 FGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTT-RTLDRDQGPSSFDFTVTAVDGGGLK 666
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+V + DENDN PQF + Y + + P + + A D D+G +
Sbjct: 667 SMVYVKVFLS--DENDNPPQFYPREYAASISAQSPPG-------TAVLRLRAHDPDQGSH 717
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGV--VSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLH 1342
+SY I GN F ++ ++G+ V+ A L I A D G Q + R+
Sbjct: 718 GRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVD 777
Query: 1343 IEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-EPPG--IPLWFDITGGNYD 1399
I + P PI FE+ + F+V E +G++ PPG P+ ++GG+
Sbjct: 778 ISIV--PGTPTPPI-FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPR 834
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSN-YNLTVEATDGTTTILTQVFIKVI--DTNDHRPQF 1456
F +D +G + +PLD E L V A G ++V+ D ND+ P F
Sbjct: 835 GLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAF 894
Query: 1457 STSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSL 1514
+ V++P +TAP T I + A+D D +++ +TL + F +DP TG +
Sbjct: 895 PAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG----GAFTVDPTTGHV 950
Query: 1515 YTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD--TNDHAPWFTASSYKGRVY 1572
L H L + RD P + + R+ V V D T AP F + +Y+ +
Sbjct: 951 RLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLP 1010
Query: 1573 ESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAE 1632
G+ VLQV A D G + Y + + + F ++P G + LDR Q
Sbjct: 1011 SGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQEL 1067
Query: 1633 YDLMVKATDKGSPPMSEIT---SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
Y L V A + + T +VR+ + + SP+ + + ++E G+ VG V
Sbjct: 1068 YILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRV 1127
Query: 1690 TAHSQSS-----VVYEIKD-GNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA 1743
A + S + Y ++ AF I+P +G + T + LD E Y L++Q +
Sbjct: 1128 FATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187
Query: 1744 GLSTNTTVLVHLQ--DENDNAPVFMQAEYTGLISESASINSVVLTDRNVP----LVIRAA 1797
+TT VH+ D NDN+P F+QA +G I + DR P ++A
Sbjct: 1188 SPPRSTTGTVHVAVLDLNDNSPTFLQA--SGAAGGGLPIQ---VPDRVPPGTLVTTLQAK 1242
Query: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL 1857
D D+ N ++Y + P F++ +G + T L E + T+ HD G+P
Sbjct: 1243 DPDEGENGTILYTLTGPG-SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPR 1301
Query: 1858 FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDA----------- 1906
A + + V V+ A+P + + P V+TV A +
Sbjct: 1302 SA--SLQLLVQVLP----SARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVA 1355
Query: 1907 --DSSAFSQLIYSITEGNIGE-KFSMDYKTGALTVQNTTQLRSR---YELTVRAS--DGR 1958
+ + L Y++ G E F++D +G L + + LTVRA G
Sbjct: 1356 APEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGA 1415
Query: 1959 FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAI---GNPINEPLFYH 2015
A L V++ V++ E F +D + + EN L A G N + Y
Sbjct: 1416 GARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYR 1475
Query: 2016 ILN---PDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSA---VAHVVVKV 2069
+L P ++ +G LS DRE A ++VE T+ ++ A V +V
Sbjct: 1476 LLRQEPPVPALRLDARTGALSAP-RGLDRETTPALLLLVEATDRPANASRRRAARVSARV 1534
Query: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE-HFQ 2128
V D+NDNAPVF + P + D G +V A D D G V Y L + HF+
Sbjct: 1535 FVTDENDNAPVFAS-PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFR 1593
Query: 2129 I-GPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKP 2185
+ G +S+ + + + E+++TVVA D G+P SA ++ ++V +N P F++
Sbjct: 1594 LHSSTGALSVVRPLDREQ-RAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQ 1652
Query: 2186 FYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQ-FTINFNTGVINVIAPLDF 2244
YS + E+ + ++ ++A P+ + +T G S+ F+++ +TGV+ + LD
Sbjct: 1653 EYSVLLRENNPPGTSLLTLRATDPD-VGANGQVTYGGVSSESFSLDPDTGVLTTLRALDR 1711
Query: 2245 EAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVV 2303
E L++ A D + V V + V+D ND+ P F ++ + E T +
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT-LT 1770
Query: 2304 QVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAV 2363
+RA+D D N + Y++ F +D ++G +R LD E + + A
Sbjct: 1771 MLRASDPDVGANGQLQYRILDGDPSG--AFVLDLASGEFGTMRPLDREVEPAFQLRIEAR 1828
Query: 2364 DGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDID 2423
DGG P LS+ +++TV V D ND+ P F Y + E P G + ++A+D D+
Sbjct: 1829 DGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANG 1888
Query: 2424 KLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV----FRSSTQVH 2479
+ Y + +G + S+ + T + L R P Y+ ++S DG ++ V
Sbjct: 1889 HVTYYLGAGTAGAFLLEPSSGELRTAAALDREQC-PSYTFSVSAVDGAAAGPLSTTVSVT 1947
Query: 2480 VTVIGGNLHSPAFLQNEYEVELAENAPLHT----LVMEVKTTDGDSGIYGHVTYHIVNDF 2535
+TV N H+P F + + L P + + ++ D D+G + Y +
Sbjct: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTP 2007
Query: 2536 AKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI--LTDDNDNA 2593
+ G+I P ++V+ + +A D G T +I L + +
Sbjct: 2008 PPGTTVDSYTGEIRVARSPVALGPRDRVLFI--VATDLGRPARSATGVIIVGLQGEAERG 2065
Query: 2594 PQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSG 2653
P+F E I +A GT +V A A G+N ITY+I + +E K I +G
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE--KGTFSIQPSTG 2122
Query: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713
IT + S GL+ E + S + ++ + + P+F P Y +
Sbjct: 2123 AITVR-SAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLP 2181
Query: 2714 EDVP-----IGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDH 2768
E P + E D + G + YSL F +D +G + LD
Sbjct: 2182 ESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG----LFHVDPTTGTITTTAILDR 2237
Query: 2769 ETTKWYQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSR 2827
E W + ++ T + +V S +++ V D NDN P P+E + E+ GS
Sbjct: 2238 EI--WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSE 2294
Query: 2828 VIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKV 2887
+ Q+ +D DSG + Y L S + F++ G ++ LD E+ D YQ+++
Sbjct: 2295 IAQVTGNDVDSGP--VLWYVLSPSGPQ---DPFSVGRYGGRVSLTGPLDFEQCDRYQLQL 2349
Query: 2888 VASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADS 2947
+A D + + + T +V+ DVND+ P F+ +Y+ + E P G I +S TD DS
Sbjct: 2350 LAHDGPHEGRANLTVLVE----DVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405
Query: 2948 EEINRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLDREKRDNYLLTITATDGTF--- 3003
N ++Y + P F+V+ + + L + + + A D
Sbjct: 2406 -GANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGR 2462
Query: 3004 SSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD-IRSNAEITYTL 3062
+++A V V++ D ND++P + Y + ED+ PG ++ + ATDAD RS+A + Y++
Sbjct: 2463 AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSI 2522
Query: 3063 L-GSGAEKFKLNPDTGELKTST--------------PLDREEQAVYHLLVRATDGGGRFC 3107
+ G+ F+L P E S PLD E Y+L V A D G+
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD-RGQPP 2581
Query: 3108 QASIV---LTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL 3164
Q+S+V +T+ DVNDN P F+ Y +TV E+T G L V+A+DAD G + + ++
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT- 2640
Query: 3165 IDSAD--GQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLD 3222
+ S D G F ++E SG ++L LD E QA + L ++A D A V + V D
Sbjct: 2641 VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAH--FALAPVTIEVQD 2698
Query: 3223 INDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE----HGKF 3278
+ND+ P F +V+E+ GT V ++A D A + YS++ F
Sbjct: 2699 VNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAF 2758
Query: 3279 SIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQD 3338
+++S TG + DYE + + L V A D G +LS TV+V VT ++ PVF
Sbjct: 2759 ALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAP 2816
Query: 3339 TYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSI 3374
+ + E A S+ V A D DG ++ + YS+
Sbjct: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 757 bits (1954), Expect = 0.0
Identities = 780/2892 (26%), Positives = 1244/2892 (43%), Gaps = 262/2892 (9%)
Query: 107 ILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+L+RE +D Y T A +V V+V D ND P F ++ +PE+TA T
Sbjct: 106 VLDREQRDRYRFTAV-----TPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
Query: 167 SIARVSATDADIGTNGEFYYSFK--DRTDMFAIHPTSG-------VIVLTGRLDYLETKL 217
A DAD G G Y+ + F + G +V+TG LD
Sbjct: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
Query: 218 YEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA----VTLSPSELDRDPAY 273
Y +++ A D GS + A L V + N+ AP +S S P
Sbjct: 221 YMLQLEAYDG-----GSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
Query: 274 AIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGY- 332
V D D G NG + R G + + A G+ P +
Sbjct: 276 Q-VFASDADAGVNGAVT-----------YEINRRQSEGDGPFSIDAHTGLLQLERPLDFE 323
Query: 333 -----NLTLQAKDKGTPPQFSSVKV-IHV--TSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
L +QA+D G P+ S V +HV + + V F ++SE APP
Sbjct: 324 QRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQ 383
Query: 385 PVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTG---LISILEPVKRQQAAHFELE 437
V + ++H+ + G+ F+L+ L+ + + R++ + L
Sbjct: 384 LVARISVSDPDDGDFAHVNVSLEG--GEGHFALSTQDSVIYLVCVARRLDREERDAYNLR 441
Query: 438 VTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPI-GTTVMSLSAVDPD 491
VT +D +A ++ V N N P F + Y+ V + G+ V+ ++A DPD
Sbjct: 442 VTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPD 501
Query: 492 EGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
+G NG VTYS+A H F+ID +G ++T+ +LDYEL P+ L + A+D GLP
Sbjct: 502 QGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP-QLIVVATDGGLPPLAS 560
Query: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEA 608
++ L ++NDN P F++ ++P G V+A DAD L+ Y + A
Sbjct: 561 -SATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
Query: 609 G---NELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAA 665
G + F ++ +SG + R+L G S +TA DG + +Y+ + ++
Sbjct: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGP--SSFDFTVTAVDGGGLKSMVYVKVFLS- 676
Query: 666 SHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQ 725
N + PQF
Sbjct: 677 ------------------------------------------DENDNPPQFYPR-EYAAS 693
Query: 726 VKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETT 785
+ P G++V+ + + D D G +G+L Y + GN F +D ++G+L + PL R
Sbjct: 694 ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRAN 753
Query: 786 DKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
L I D G Q + + +V PP F Q Y V ED + + V+
Sbjct: 754 SVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQ 813
Query: 846 ATDKDLGPNGHVTYSIV--TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903
A + G VT S+ FS+D+V+G++ RPLDREL L++E R
Sbjct: 814 AHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEVR-AGSG 870
Query: 904 EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR 963
P F+ V+V L+DVNDN P F P V + + GT I L A DPD G + +V
Sbjct: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
Query: 964 YSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVV 1023
++LL G G F VD +G VR+++ L + L + A+D G P +S + V V
Sbjct: 931 FTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP-PRTSHFRLRVVVQ 989
Query: 1024 DVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFK 1083
DV P F+S + + G+ V+ V A D G I Y + F
Sbjct: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDG---GPITYHLAAEGASSPFG 1046
Query: 1084 IGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPL---SSFIEIYIEVEDVNDNAPQTS 1140
+ ++G + LDRE+ Y L V A L + + + + + N+++P+ S
Sbjct: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
Query: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITS-GNPQGFFSIHPKTGLITTT 1199
E + + EN P SV ++ A D DS N +L Y + F IHP+TG +TT
Sbjct: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
Query: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKF------YKIR 1253
+ LDREQQ + L V V D GSPP+ST V V +LD NDN P FLQ I+
Sbjct: 1167 -QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
Query: 1254 LPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG--VVSS 1311
+P+R P + A D DEG N I Y++ G F + P +G + ++
Sbjct: 1226 VPDRVPPGTLVTTLQ-------AKDPDEGENGTILYTL-TGPGSELFSLHPHSGELLTAA 1277
Query: 1312 KRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE-----WISKPKPSL---EPISFEESFF 1363
A + +L++ A D G P +S++ +L ++ +++P P L +P +
Sbjct: 1278 PLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL 1337
Query: 1364 TFTVMESDPVAHMIG-VISVEPPGI-PLWFDITGG-NYDSHFDVDKGTGTIIVAKPLDAE 1420
T T E ++G V + EP G+ L + + GG + + F +D +G + +A+PLD E
Sbjct: 1338 TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
Query: 1421 QKSNYN-LTV--EATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQ 1477
+ LTV E G L +V ++V D N+H P F+ + +PE+ P +
Sbjct: 1398 AGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT 1457
Query: 1478 ISAVDQD---EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
A D D + + Y L P + RLD TG+L LD E L V
Sbjct: 1458 FRASDADGPGPNSDVRYRLLRQEPP--VPALRLDARTGALSAPRGLDRETTPALLLLVEA 1515
Query: 1535 RDQDVPVKRNFARIV---VNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
D+ R A V V V+D ND+AP F AS + R+ E G L V A D D
Sbjct: 1516 TDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAALHVVARDPDL 1574
Query: 1592 GKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEIT 1651
G+ A V Y + SG G+ F + G++ + LDR +AE+ L V A+D GSPP S
Sbjct: 1575 GEAARVSYRLASGGDGH-FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQ 1633
Query: 1652 SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA-----HSQSSVVYEIKDGNT 1706
+ + V ++ +P F +EYSV L E G+ + + A + V Y G +
Sbjct: 1634 VLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVS 1690
Query: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLVHLQDENDNAPV 1764
++F ++P +G + T +ALD E L + Q T+ TV V ++DEND+AP
Sbjct: 1691 SESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
Query: 1765 FMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDS 1824
F A + + E D ++RA+D D +N L Y I++ F +D
Sbjct: 1751 FGSAHLSLEVPEG--------QDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
Query: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
++G T+ LD E F ++ D G P L A +TV V+D ND P F P Y
Sbjct: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLL--LTVTVLDANDHAPAFPVPAY 1860
Query: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQL 1944
+ G ++ + A D D+ A + Y + G G F ++ +G L
Sbjct: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG-AFLLEPSSGELRTAAALDR 1919
Query: 1945 RS--RYELTVRASDGRFAG----LTSVKINVKESKESHLKF-TQDVYSAVVKEN-STEAE 1996
Y +V A DG AG SV I V++ + F T + + + S
Sbjct: 1920 EQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTP 1979
Query: 1997 TLAVITAIGNP----INEPLFYHIL-NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVV 2051
TLA+ T N + Y + P + +G + +P ++ +V
Sbjct: 1980 TLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIV 2039
Query: 2052 EVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSG 2111
T+ +P+ A V+ V ++ + + P F A ++ + G I AV G
Sbjct: 2040 -ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGG 2097
Query: 2112 RNGEVHYYLKEHHEH--FQIGP-LGEISLKKQFELD-TLNKEYLVTVVAKDGGNPAFSAE 2167
NG + Y + +E F I P G I+++ LD ++ + + A+ GG AF+
Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV- 2156
Query: 2168 VIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSITDGDPF 2224
+ + + N P F +P Y A + ES + P++ V+A+ + G ++ YS+ P
Sbjct: 2157 LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
Query: 2225 -SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGA-HAEVFVDIIVDDINDNPPV 2282
F ++ TG I A LD E +L + ATD + A + ++V D NDN P
Sbjct: 2217 RGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT 2276
Query: 2283 FAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLI 2342
Q + + +SE +++G+ + QV D DS P + Y + + S D F V G +
Sbjct: 2277 I-PQPWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVL--SPSGPQDPFSVGRYGGRV 2331
Query: 2343 SLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEH 2402
SL LD+EQ ++ + + A DG ++ +TV V D+NDN P F Q +Y+ + EH
Sbjct: 2332 SLTGPLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLYQVMLLEH 2388
Query: 2403 APHGHFVTCVKAYDADSSDIDKLQYSILS-----GNDHKHFVIDSATGIITLSNLHRHAL 2457
P G + V A D DS + Y + S D + + + G + L + A+
Sbjct: 2389 TPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAV 2448
Query: 2458 KPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTT 2517
+ G +T VHV + N H+P+F + Y V + E+ P + ++ ++ T
Sbjct: 2449 DVVLEARDHGAPGRAARAT-VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
Query: 2518 DGD-SGIYGHVTYHIVNDFAKDRFYINER---------------GQIFTLEKLDRETPAE 2561
D D S + V Y I++ F + R G + LE LD E+ +
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
Query: 2562 KVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
++V + + + V V + D NDN P F Y V + G ++ V AS
Sbjct: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP 2681
DAD G + + + + + S E+++ SG + +L V+A D
Sbjct: 2628 DADPGPHGLVRFTVSSGDPS--GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG- 2684
Query: 2682 SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHS-----GTVLYS 2736
+ ++ V +++ P F + +V+E+ P GT + + A G + YS
Sbjct: 2685 AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYS 2744
Query: 2737 LVK-GNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDV 2795
L++ G PE E+F ++ +G L+ D+E T+ ++ + A D + ASV V
Sbjct: 2745 LLEAGPGPEGR--EAFALNSSTGELRARVPFDYEHTESFRLLVGA---ADAGNLSASVTV 2799
Query: 2796 SIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVE 2855
S+ V ++ PVF + + + E G + ++A+D D G +G V+YSL S
Sbjct: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY- 2858
Query: 2856 VIESFAINMETG 2867
F IN TG
Sbjct: 2859 ----FGINQTTG 2866
Score = 724 bits (1868), Expect = 0.0
Identities = 770/2874 (26%), Positives = 1235/2874 (42%), Gaps = 241/2874 (8%)
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
+ID +GVV AR LDRE + + D A TV V V + D+ND+ P F
Sbjct: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGA--------TVEVTVRVADINDHAPAFP 144
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGA----- 982
++V E GT A D D G+ G Y+L G G F ++ G
Sbjct: 145 QARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPV 204
Query: 983 --VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ + +LD E + Y L + A D G P + ++V ++D+N+ H P F+
Sbjct: 205 PELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQAL-LDVTLLDIND--HAPAFNQSRYH 261
Query: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI--RDGSGVGVFKIGEETGVIETSDRLD 1098
V E GS V+ V A D DA +G + Y I R G G F I TG+++ LD
Sbjct: 262 AVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLD 321
Query: 1099 RESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYY------PEIMENS 1152
E + L V A D G P + + V D NDN P S V + P++ E +
Sbjct: 322 FEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP--SMTVIFLSADGSPQVSEAA 379
Query: 1153 PKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLI--TTTSRKLDREQQDE 1210
P V +I DPD + + G +G F++ + +I +R+LDRE++D
Sbjct: 380 PPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVARRLDREERDA 437
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIR-LPEREKPDRERNARRE 1269
+ L VT TD+GSPP A ++ + D NDN P F ++ Y+ LPE P
Sbjct: 438 YNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSF------ 491
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-----LS 1324
+ V A D D+G N +++YS+ G F I+P +G++++ +A+ +Y++ L
Sbjct: 492 -VVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITT---AASLDYELEPQPQLI 547
Query: 1325 IKAVDNGRPQ--KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVME-SDPVAHMIGVIS 1381
+ A D G P S+T + ++ ++ +P F+ +F+ ++ E + P + V +
Sbjct: 548 VVATDGGLPPLASSATVSVALQDVNDNEPQ-----FQRTFYNASLPEGTQPGTCFLQVTA 602
Query: 1382 VEPPGIP---LWFDITGGNYDSH---FDVDKGTGTIIVAKPLDAEQ-KSNYNLTVEATDG 1434
+ P L + + G S F +D +G + + LD +Q S+++ TV A DG
Sbjct: 603 TDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDG 662
Query: 1435 TTTILTQVFIKVI--DTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN--KLI 1490
+ + V++KV D ND+ PQF +Y I + P T +L++ A D D+ + +L
Sbjct: 663 GG-LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLS 721
Query: 1491 YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVV 1550
Y + + P F LD +G L + L A L + D AR+ +
Sbjct: 722 YHILAGNSP---PLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDI 778
Query: 1551 NVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSF 1610
++ P F Y V E A G+ V V A G+ A V S+ G+ F
Sbjct: 779 SIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLF 837
Query: 1611 MIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSK 1670
+D V G ++T + LDR + G PP + VR+ + ++ SP F +
Sbjct: 838 SLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897
Query: 1671 EYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKAL 1725
E +V L + G+ + + A S V + + G G AF ++P +G + + L
Sbjct: 898 EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPL 956
Query: 1726 DFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDENDN--APVFMQAEYTGLISESASIN 1781
P + L ++ + +++ + V +QD AP F Y + +
Sbjct: 957 GPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAG 1016
Query: 1782 SVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETS 1841
+ VL A + YH+ + F ++ +G + +LD E
Sbjct: 1017 TQVLQ----------VQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQE 1066
Query: 1842 IFHFTVQVHDMGTPRLFAEYA-ANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT 1900
++ V L + A V V +++ N+ P ++ ++ G V
Sbjct: 1067 LYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR 1126
Query: 1901 VNATDADSSAFSQLIYSITEGNIGEK-FSMDYKTGALTVQNTT--QLRSRYELTVRASDG 1957
V ATD DS +L YS+ + + K F + +TG +T T + +S Y+L V+ DG
Sbjct: 1127 VFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDG 1186
Query: 1958 RFAGLTS---VKINVKESKESHLKFTQDVYSA-----VVKENSTEAETLAVITAIGNPI- 2008
++ V + V + ++ F Q +A + + TL +P
Sbjct: 1187 GSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDE 1246
Query: 2009 --NEPLFYHILNPDRR-FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP--SAVA 2063
N + Y + P F + SG L T P R ++ + + + ++ P SA
Sbjct: 1247 GENGTILYTLTGPGSELFSLHPHSGEL-LTAAPLIRAERPHYVLTLSAHDQGSPPRSASL 1305
Query: 2064 HVVVKVI-----------VEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
++V+V+ + +++ APV V L A + G ++ V A +
Sbjct: 1306 QLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGL--RPGSLLGSVAAPE--PAG 1361
Query: 2113 NGEVHYYL---KEHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKD-GGNPAFSAE 2167
G + Y L + F + G + L + + + +TV A+ GG A
Sbjct: 1362 VGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLR 1421
Query: 2168 VIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEG----LKVFYSITDGDP 2223
V V + N+ P F + + + E+ + + + +A+ +G V Y + +P
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEP 1481
Query: 2224 -FSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH----AEVFVDIIVDDIND 2278
++ TG ++ LD E PA L + ATD A A V + V D ND
Sbjct: 1482 PVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDEND 1541
Query: 2279 NPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
N PVFA S V L E G + + V A D D +SY++ S HF + SS
Sbjct: 1542 NAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLA---SGGDGHFRLHSS 1597
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
TG +S++R LD EQ +H + V A D G P S+ ++TV V D+ND P F+QQ Y
Sbjct: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL 1657
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHAL 2457
+ E+ P G + ++A D D ++ Y G + F +D TG++T L L R
Sbjct: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQ 1714
Query: 2458 KPFYSLNLSVSDGVFRSSTQ-----VHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM 2512
+ +NL+V S Q V V V N H+P F +E+ E TL M
Sbjct: 1715 E---EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM 1771
Query: 2513 EVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLDRETPAEKVISVRLMAK 2571
++ +D D G G + Y I++ F ++ G+ T+ LDRE E +R+ A+
Sbjct: 1772 -LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREV--EPAFQLRIEAR 1828
Query: 2572 DAGGKVAFCTVNVILT--DDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNA 2629
D G T+ + +T D ND+AP F Y V + GT ++++ A D D G+N
Sbjct: 1829 DGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANG 1888
Query: 2630 DITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESV--- 2686
+TY + A + + SG + T +L + +TF V AVD + S
Sbjct: 1889 HVTYYLGAGTAGA---FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
Query: 2687 VLVYVKIL----------PPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYS 2736
V + V+ + P ++LP+ F T T++ + D A + ++LY
Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRD---AGANASILYR 2002
Query: 2737 LVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVS 2796
L G P +D +G +++ +S + I+A V +
Sbjct: 2003 LA-GTPPPGT-----TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV-II 2055
Query: 2797 IQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEV 2856
+ ++ + P F + EA I EN P G+ ++ RA A GTNG + YS+
Sbjct: 2056 VGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKG- 2113
Query: 2857 IESFAINMETGWIT--TLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDS 2914
+F+I TG IT + + LD E ++ + A G + ++ +T+ D ND+
Sbjct: 2114 --TFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA----FAFTVLTLTLQDANDN 2167
Query: 2915 PPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL-GQFAVETIQ 2973
PRF Y + E P G + + D D Q++Y + P G F V+
Sbjct: 2168 APRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS-GGQISYSLAASQPARGLFHVDPTT 2226
Query: 2974 NEWKVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSD 3030
+ LDRE L + ATD A + V V+D NDN P + +
Sbjct: 2227 GT--ITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WEL 2283
Query: 3031 TIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREE 3089
+ ED L G I Q++ D D S + Y L SG + F + G + + PLD E+
Sbjct: 2284 RVSEDALLGSEIAQVTGNDVD--SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQ 2341
Query: 3090 QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
Y L + A DG +A++ + +EDVNDNAP FS Y + + E+T PG+ + V A
Sbjct: 2342 CDRYQLQLLAHDGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA 2400
Query: 3150 TDADAGLNRKILYSLIDSADGQFSINELSGIIQL---EKPLDRELQAVYTLSLKAVDQGL 3206
TD D+G N I Y L ADG FS++ +G + L + + L+A D G
Sbjct: 2401 TDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGA 2459
Query: 3207 PRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD-IEANAEI 3265
P R A TV V + D ND+ P F Y V+ED+ G+ +L + A D ++A +
Sbjct: 2460 PGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAV 2518
Query: 3266 TYSIISGNEHGKFSIDSKT--------------GAVFIIENLDYESSHEYYLTVEATDGG 3311
YSIISGN F ++ + G + ++E LD+ES +Y LTV A D G
Sbjct: 2519 DYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRG 2578
Query: 3312 TPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIH 3371
P S V V V V D+NDN PVF++ +Y + ED + ++ V A DAD + +
Sbjct: 2579 QPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVR 2638
Query: 3372 YSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVS 3431
+++ G+ F +D G +++ LD ET + + L VQA+D V I+V
Sbjct: 2639 FTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG-AHFALAPVTIEVQ 2697
Query: 3432 DVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTG---NDEKA 3488
DVND+ P F S + EN+P G V L D D+ G + + G +A
Sbjct: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA 2757
Query: 3489 FEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILP 3547
F +N G L + + + L V AD G LS+ + + V E Y P L
Sbjct: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLA 2815
Query: 3548 LEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKL 3599
G +G + ATD+D + YSL F ++ T G L
Sbjct: 2816 PAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGAL 2868
Score = 699 bits (1803), Expect = 0.0
Identities = 725/2762 (26%), Positives = 1185/2762 (42%), Gaps = 248/2762 (8%)
Query: 105 TAILNREVKDHYTLIVKALEKNTNVE-ARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTA 163
T L+RE + HY L ++A + + A+ + V +LD ND P F+ + Y + E+ A
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 164 IRTSIARVSATDADIGTNGEFYYSFKDRTD----MFAIHPTSGVIVLTGRLDYLETKLYE 219
+ + +V A+DAD G NG Y R F+I +G++ L LD+ + +++E
Sbjct: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
Query: 220 MEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL----SPSELDRDPAYAI 275
+ + A D G S A +TVH+ AN+ P +T + L SP + P +
Sbjct: 330 LVVQARDGGAHPELGS-----AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQL 384
Query: 276 VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLT 335
V +GD A +++ F S S Y V +D + YNL
Sbjct: 385 VARISVSDPDDGDFAHVNVSLEGGEGHF--ALSTQDSVIYLVCVARRLDREERD-AYNLR 441
Query: 336 LQAKDKGTPP-QFSSVKVIHVTSPQFKAGPVKFEKDVYRAE-ISEFAPPNTPVVMVKA-- 391
+ A D G+PP + + V+HVT A F++ +YR E + E A P + VV V A
Sbjct: 442 VTATDSGSPPLRAEAAFVLHVTDVNDNA--PAFDRQLYRPEPLPEVALPGSFVVRVTARD 499
Query: 392 IPAYSHLRYVFKSTPGKAK--FSLNYNTGLISILEPVKRQQAAHFELEVTTSD-----RK 444
++ + + PG FS++ +G+I+ + + +L V +D
Sbjct: 500 PDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559
Query: 445 ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYS--- 501
+S V V + N N P+F +T Y A+ E GT + ++A D D G G ++YS
Sbjct: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
Query: 502 -IANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLN 560
+ + PF ID +G V T+ LD + P + + A D G + V + L+
Sbjct: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG---GLKSMVYVKVFLS 676
Query: 561 NLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLN 618
+ NDN P F +I G + + A D D+ + Y I AGN F+L+
Sbjct: 677 DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD 736
Query: 619 PNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETG 678
SG+L++ L + V L I A DG LQ E +
Sbjct: 737 EQSGLLTVAWPLARRANSVV---QLEIGAEDGG-------------------GLQAEPSA 774
Query: 679 VAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIF 738
+ S P L V E+ G+SV
Sbjct: 775 RVDI-----------------------SIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGI 811
Query: 739 MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLG 798
+ + + G + ++SGG+ F +D +G+L+ L PLDRE G
Sbjct: 812 VQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSG 870
Query: 799 IPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVT 858
+P A + V++ D NDN P F V + + + I + A D D G N VT
Sbjct: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
Query: 859 YSIVT-DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSL 917
++++ F++D TG V + RPL H L++EARD P S ++V +
Sbjct: 931 FTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG--SPPRTSHFRLRVVV 988
Query: 918 EDVNDN--PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-F 974
+DV P F P YRV + GT ++ ++A PD G + Y L G + F
Sbjct: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPF 1045
Query: 975 DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVF 1034
++ SG + + LD E +++Y L V A K T V V +N+N H P
Sbjct: 1046 GLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL 1105
Query: 1035 SSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD-GSGVGVFKIGEETGVIET 1093
S V E+ P G+ V V A D D+ +G + YS++ F+I +TG + T
Sbjct: 1106 SEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTT 1165
Query: 1094 SDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSE---------PVY 1144
LDRE S Y L V D G P S+ +++ V D+NDN+P + P+
Sbjct: 1166 LQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
Query: 1145 YPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLD 1204
P + P V ++A DPD N ++Y +T G FS+HP +G + T + L
Sbjct: 1226 VP---DRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAA-PLI 1280
Query: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDE---NDNKPQFLQKFYKIRLPEREKPD 1261
R ++ ++L ++ D GSPP+S +++V++L + P ++ +P
Sbjct: 1281 RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340
Query: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDG-NEHGKFFIEPKTGVVSSKR---FSAA 1317
R L +A + G A ++Y++ G + G F ++ +G + R F A
Sbjct: 1341 AAEGLRPGSLLGSVAAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAG 1399
Query: 1318 GEYDILSIKAV-DNGRPQKSSTTRLHIEWISKPKPSL--EPISFE--------ESFFTFT 1366
+ L+++A G + ++ ++ ++ P+ +P++ + +TF
Sbjct: 1400 PPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459
Query: 1367 VMESD---PVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
++D P + + + + P +P +D TG + + LD E
Sbjct: 1460 ASDADGPGPNSDVRYRLLRQEPPVPA------------LRLDARTGALSAPRGLDRETTP 1507
Query: 1424 NYNLTVEATD--------GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI 1475
L VEATD + +VF V D ND+ P F+ S V +PED P
Sbjct: 1508 ALLLLVEATDRPANASRRRAARVSARVF--VTDENDNAPVFA-SPSRVRLPEDQPPGPAA 1564
Query: 1476 LQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533
L + A D D E ++ Y L S D FRL +TG+L LD E +H LTV+
Sbjct: 1565 LHVVARDPDLGEAARVSYRLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
Query: 1534 VRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGK 1593
D P + + V+V+D ND AP F Y + E+ G+ +L + A D D G
Sbjct: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
Query: 1594 NAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSV 1653
N +V Y G SF +DP G + T + LDR Q E +L V A D+GSPP +V
Sbjct: 1681 NGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
Query: 1654 RIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYEIKDGNTGDA 1709
R+ V ++ +P F S S+E+ E + + + + + Y I DG+ A
Sbjct: 1738 RVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGA 1797
Query: 1710 FDINPHSGTIITQKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQ 1767
F ++ SG T + LD E P + L I+ + LS + V + D ND+AP F
Sbjct: 1798 FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPV 1857
Query: 1768 AEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG 1827
Y+ + E +++L ++A D D +N + Y++ + F ++ S+G
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQ-------LQAHDPDAGANGHVTYYLGAGTAGA-FLLEPSSG 1909
Query: 1828 AIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEAS 1887
+ T +LD E+ + F+V D G +VT+ V D+ND P F P
Sbjct: 1910 ELRTAAALDREQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTF--PTSPLR 1966
Query: 1888 LLLP------TYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNT 1941
L LP + + + T+ A D D+ A + ++Y + G ++D TG + V +
Sbjct: 1967 LRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARS 2025
Query: 1942 TQL---RSRYELTVRASDGRFAGLTS--VKINVKESKESHLKFTQDVYSAVVKENSTEAE 1996
R R V GR A + + + ++ E +F + A ++EN+
Sbjct: 2026 PVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGT 2085
Query: 1997 TLAVITAI-GNPINEPLFYHILNPDRR--FKISRTSGVLST-TGTPFDREQQEAFDVVVE 2052
+ A+ N P+ Y IL+ + + F I ++G ++ + D E +V++
Sbjct: 2086 PIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
A A V+ + ++D NDNAP F+ Y A + + + V A D D G
Sbjct: 2146 A---ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS 2202
Query: 2113 NGEVHYYLKEHHEH---FQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAF--SA 2166
G++ Y L F + P G I+ + + + LV ++A D G+PA SA
Sbjct: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLV-LMATDRGSPALVGSA 2261
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSITDGDPFS 2225
+ V + N P +P + ++E + S + V N + G ++Y ++ P
Sbjct: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQD 2320
Query: 2226 QFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFA 2284
F++ G +++ PLDFE Y+L + A D G H + ++V+D+NDN P F+
Sbjct: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPHEGRANLTVLVEDVNDNAPAFS 2377
Query: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG-LIS 2343
Q Y V L E + G++++ V ATD DS N ISY + + D F VD + G L +
Sbjct: 2378 QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL----ASPADGFSVDPNNGTLFT 2433
Query: 2344 LLRT--LDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
++ T L ++ S + + A D G P ++ V V + D ND+ P F Y ++E
Sbjct: 2434 IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
Query: 2402 HAPHGHFVTCVKAYDADSS-DIDKLQYSILSGNDHKHFVID--------------SATGI 2446
P G + ++A DAD S + YSI+SGN + F ++ A G
Sbjct: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGC 2553
Query: 2447 ITLSNLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAE 2503
+ L Y+L ++ +D S V VTV+ N + P F + Y V + E
Sbjct: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPE 2613
Query: 2504 NAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEK 2562
+ P+ ++ V+ +D D G +G V + + + F ++E G + LD ET A
Sbjct: 2614 DTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARH 2673
Query: 2563 VISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASD 2622
+ V+ A AG A V + + D ND+ P F ++ + GT V + A D
Sbjct: 2674 QLVVQ-AADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAID 2732
Query: 2623 ADEGSNADITYAI--EADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2680
D G+ + Y++ +E +N +G + + E F V A D G+
Sbjct: 2733 GDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN 2792
Query: 2681 PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLY 2735
S + V V V + + P F P + F V E G + ++A G VLY
Sbjct: 2793 LS--ASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLY 2850
Query: 2736 SL 2737
SL
Sbjct: 2851 SL 2852
Score = 624 bits (1609), Expect = e-178
Identities = 661/2374 (27%), Positives = 1013/2374 (42%), Gaps = 165/2374 (6%)
Query: 1369 ESDPVAHMIGVISVEPPG---IPLWFDIT---GGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422
E P +IG IS P PL + I+ G + +D+ +G + A+ LD EQ+
Sbjct: 53 EEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR 112
Query: 1423 SNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVD 1482
Y T DG T +V ++V D NDH P F ++ + +PE TA T A D
Sbjct: 113 DRYRFTAVTPDGAT---VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARD 169
Query: 1483 QDEKNKLIYTLQSSRDPLSLKKFRLDPATG-------SLYTSEKLDHEAVHQHTLTVMVR 1535
D S D + FRL+ G L + +LD E + L +
Sbjct: 170 ADAGRLGTQGYALSGDGAG-ETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAY 228
Query: 1536 DQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNA 1595
D P +R A + V + D NDHAP F S Y V ES A GS VLQV A D D G N
Sbjct: 229 DGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNG 288
Query: 1596 EVLYSI--ESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSV 1653
V Y I F ID G ++ + LD + ++L+V+A D G+ P V
Sbjct: 289 AVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFV 348
Query: 1654 RIFVTIADNASPK----FTSKEYSVELSETVSIGSFVGMVTAHSQS----SVVYEIKDGN 1705
+ V A++ P F S + S ++SE G V ++ + V +G
Sbjct: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408
Query: 1706 TGDAFDINPHSGTI---ITQKALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDEND 1760
G F ++ I + LD E Y L + T+ L ++H+ D ND
Sbjct: 409 EGH-FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467
Query: 1761 NAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT- 1818
NAP F + Y + E A S V+ + A D D+ +N + Y + P HT
Sbjct: 468 NAPAFDRQLYRPEPLPEVALPGSFVVR-------VTARDPDQGTNGQVTYSLA-PGAHTH 519
Query: 1819 YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPV 1878
+F+ID ++G I T SLDYE V D G P L + +A V+V + D+ND P
Sbjct: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLAS--SATVSVALQDVNDNEPQ 577
Query: 1879 FAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEG---NIGEKFSMDYKTGA 1935
F + Y ASL T G + V ATDADS F L YS+ G + F +D +G
Sbjct: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
Query: 1936 LTVQNT---TQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHLKFTQDVYSAVVK 1989
+ T Q S ++ TV A DG GL S VK+ + + ++ +F Y+A +
Sbjct: 638 VCTTRTLDRDQGPSSFDFTVTAVDG--GGLKSMVYVKVFLSDENDNPPQFYPREYAASIS 695
Query: 1990 ENSTEAETLAVITA--IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQE 2045
S + + A + L YHIL N F + SG+L T P R
Sbjct: 696 AQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLL-TVAWPLARRANS 754
Query: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTA 2105
+ + + A V + + P+F L Y V D G + V A
Sbjct: 755 VVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA 814
Query: 2106 VDRDSGRNGEVHYYLK--EHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNP 2162
GR V L + F + + G + + + + L + V A G P
Sbjct: 815 -HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873
Query: 2163 AFS-AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSI 2218
AF+ A V V + +N P F P + + + +P+ ++A P+ +V +++
Sbjct: 874 AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933
Query: 2219 TDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF-VDIIVDDIN 2277
G FT++ TG + ++ PL PA++L + A D + F + ++V D+
Sbjct: 934 LAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVG 992
Query: 2278 DN--PPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV 2335
P F +Y V L + GT V+QV+A D P I+Y + + S F +
Sbjct: 993 TRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASS--PFGL 1047
Query: 2336 DSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDV-IVTVDVTDLNDN---PPLFE 2391
+ +G + + LD E + + V AV G L TV V+ LN N P L E
Sbjct: 1048 EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSE 1107
Query: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILS-GNDHKHFVIDSATG-IITL 2449
+ A ++E+ P G V V A D DS +L YS+ D K F I TG + TL
Sbjct: 1108 DPTFLA-VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
Query: 2450 SNLHRHALKPFYSLNLSVSDGVF--RSST-QVHVTVIGGNLHSPAFLQ------NEYEVE 2500
L R + Y L + V DG RS+T VHV V+ N +SP FLQ ++
Sbjct: 1167 QTLDREQ-QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
Query: 2501 LAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPA 2560
+ + P TLV ++ D D G G + Y + ++ G++ T L R
Sbjct: 1226 VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERP 1285
Query: 2561 EKVISVRLMAKDAGGKVAFCTVNVIL---------TDDNDNAPQFRATKYEVNIGSSAAK 2611
V++ L A D G ++ +++ D A + A V + +AA+
Sbjct: 1286 HYVLT--LSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
Query: 2612 GTSVVKVLASDA--DEGSNADITYAIEADSESVKENLEINKLSGVITTKESL-IGLENEF 2668
G +L S A + +TY + ++ + ++ SG + L +
Sbjct: 1344 GLRPGSLLGSVAAPEPAGVGALTYTLVGGADP-EGTFALDAASGRLYLARPLDFEAGPPW 1402
Query: 2669 FTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE 2728
VRA G ++ V V++ P F+ + E+ G + RA
Sbjct: 1403 RALTVRAEGPGGAGAR-LLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
Query: 2729 H------SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILA-- 2780
+ V Y L++ P + +D ++G L + LD ETT + A
Sbjct: 1462 DADGPGPNSDVRYRLLRQEPPV----PALRLDARTGALSAPRGLDRETTPALLLLVEATD 1517
Query: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
R A V + V D NDN+PVF +SP + E+ P G + + A D D G
Sbjct: 1518 RPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAALHVVARDPDLGE 1576
Query: 2841 NGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSS 2900
+V Y L F ++ TG ++ ++ LD E+R + + VVASDHG + S+
Sbjct: 1577 AARVSYRLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR-SA 1631
Query: 2901 TAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG 2960
T ++ V+V DVND P F + Y + E++P G + L TD D N QVTY G
Sbjct: 1632 TQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPD-VGANGQVTY---G 1687
Query: 2961 GDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS---SKAIVEVKVLDAN 3017
G F+++ + + + LDRE+++ LT+ A D + V V V D N
Sbjct: 1688 GVSSESFSLD--PDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEN 1745
Query: 3018 DNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDT 3076
D++P S +PE P L M + A+D D+ +N ++ Y +L G + F L+ +
Sbjct: 1746 DHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLAS 1804
Query: 3077 GELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITV 3134
GE T PLDRE + + L + A DGG A+++LT+ D ND+AP F Y++ V
Sbjct: 1805 GEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEV 1864
Query: 3135 FENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAV 3194
E+ GTLL ++QA D DAG N + Y L G F + SG ++ LDRE
Sbjct: 1865 PEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPS 1924
Query: 3195 YTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVF-------EYREYGATVSEDILVGT 3247
YT S+ AVD L+ T +V ++V D+ND+ P F G + S L
Sbjct: 1925 YTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA-- 1982
Query: 3248 EVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEA 3307
+ + A RD ANA I Y ++G ++DS TG + + + + L + A
Sbjct: 1983 -LATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVA 2040
Query: 3308 TDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSN 3367
TD G P+ S + V + + P F + + I E+A +++ A A G +N
Sbjct: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGG-TN 2099
Query: 3368 SHIHYSIIDGNQGSSFTIDPVRGEVKVTKL--LDRETISGYTLTVQASDNGSPPRVNTTT 3425
I YSI+ GN+ +F+I P G + V LD E L +QA G+ T
Sbjct: 2100 GPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTV 2156
Query: 3426 VNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND 3485
+ + + D NDNAP F R +Y + E++P+ +LQ+ D D G + +
Sbjct: 2157 LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
Query: 3486 EKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA 3544
F V+P G + T++ + R+ L + D G P L + + VI+ + P
Sbjct: 2217 RGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT 2276
Query: 3545 ILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQ-MDNLFSVSSTGGKLIAHK 3603
I P + S + G I ++ D D L Y L P + FSV GG++
Sbjct: 2277 I-PQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG 2335
Query: 3604 KLDIGQ---YLLNVSVTDGKFTTVADITVHIRQV 3634
LD Q Y L + DG A++TV + V
Sbjct: 2336 PLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDV 2369
Score = 572 bits (1473), Expect = e-162
Identities = 603/2209 (27%), Positives = 938/2209 (42%), Gaps = 242/2209 (10%)
Query: 30 TPLQFTHLEYNVTVQENSAAKTYVG-----------HPVKMGVYITHPAWEVRYKIVSGD 78
TP F L+Y +V E+ A T VG PV + + P VSG
Sbjct: 786 TPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
Query: 79 SENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQ 138
+ L + +LG L +R G A +VRV
Sbjct: 846 LQTLRPLDRELLGPVLELEVRAGSGVPPAF----------------------AVARVRVL 883
Query: 139 VLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-KDRTDMFAI 197
+ D ND P F +V LP NTA T I + A D D G N ++ F +
Sbjct: 884 LDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTV 943
Query: 198 HPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI 257
PT+G + L L +E+E+ A D G S +S +L V ++
Sbjct: 944 DPTTGHVRLMRPLGPSGGPAHELELEARDGG-----SPPRTSHFRLRVVVQDVG------ 992
Query: 258 TAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKV 317
T + P Y + D+ S AG + Q + G Y +
Sbjct: 993 ---TRGLAPRFNSPTYRV------------DLPS-GTTAGTQVLQVQAQAPDGGPITYHL 1036
Query: 318 KAIGGIDWDSHPFGYN-----LTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPV------- 365
A G S PFG L ++A + +KV+ V+ + + G
Sbjct: 1037 AAEGA----SSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092
Query: 366 -----------KFEKDVYRAEISEFAPPNTPVVMVKAIPAYS----HLRYVFKSTPGKAK 410
+ +D ++E PP T V V A S L Y + +K
Sbjct: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK 1152
Query: 411 -FSLNYNTGLISILEPVKRQQAAHFELEVTTSD-----RKASTKVLVKVLGANSNPPEFT 464
F ++ TG ++ L+ + R+Q + ++L V D R + V V VL N N P F
Sbjct: 1153 AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFL 1212
Query: 465 QTAYKAA------FDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGA 518
Q + A + VP GT V +L A DPDEGENG + Y++ F++ +G
Sbjct: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGE 1272
Query: 519 VSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTI 578
+ T+ L P Y L + A D G P R L L + P + +
Sbjct: 1273 LLTAAPLIRAERPH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAA 1331
Query: 579 PRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKV 638
P + + TV+A + + G+ L + +GV +L +L+ G +
Sbjct: 1332 PVPV-----VLTVTAAEG---------LRPGSLLGSVAAPEPAGVGALTYTLVGGADPEG 1377
Query: 639 SFHSLRITATDGENF-ATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
+F + A G + A PL + + + ++ E G A A L Q
Sbjct: 1378 TF---ALDAASGRLYLARPL--DFEAGPPWRALTVRAEGPGGAG--------ARLLRVQV 1424
Query: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLD-TGFNGKLVYAV 756
+V+D N H P F P + + EN G+++ ++D D G N + Y +
Sbjct: 1425 QVQD-------ENEHAPAFARD-PLALALPENPEPGAALYTFRASDADGPGPNSDVRYRL 1476
Query: 757 SGGNED-SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDL---GIPQKAAWRLLHVVV 812
+D TG L LDRETT L + D ++AA V V
Sbjct: 1477 LRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFV 1536
Query: 813 VDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-FSID 871
D NDN P F S V + ED+ + V A D DLG V+Y + + D F +
Sbjct: 1537 TDENDNAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH 1595
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPN 931
S TG +++ RPLDRE + EH L + A D P +T V+ VS+ DVND PTF
Sbjct: 1596 SSTGALSVVRPLDREQRAEHVLTVVASDHG--SPPRSATQVLTVSVADVNDEAPTFQQQE 1653
Query: 932 YRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDF 991
Y V +RE+ P GT ++ L A DPD+G +GQV Y + +F +D +G + ++ LD
Sbjct: 1654 YSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS--SESFSLDPDTGVLTTLRALDR 1711
Query: 992 EKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGS 1051
E+++ NLTV A+D+G P L+ +V V V +EN H P F S V E +
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQLT---HVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768
Query: 1052 LVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFA 1111
L M + A D D +G+++Y I DG G F + +G T LDRE + L + A
Sbjct: 1769 LTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEA 1827
Query: 1112 TDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSN 1171
D G LS+ + + + V D ND+AP P Y E+ E+ P ++Q++A DPD+ +N
Sbjct: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887
Query: 1172 DKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP-PKSTIAR 1230
+ Y + +G G F + P +G + T + LDREQ + V+ D + P ST
Sbjct: 1888 GHVTYYLGAGTA-GAFLLEPSSGELRTAAA-LDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
Query: 1231 VIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYS 1290
V + + D ND+ P F ++RLP +P + L + A D+D G NA I Y
Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLP---RPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
Query: 1291 IEDGNEHGKFFIEPKTGVVSSKRFSAA-GEYD-ILSIKAVDNGRPQKSSTTRLHIEWISK 1348
+ G ++ TG + R A G D +L I A D GRP +S+T + + +
Sbjct: 2003 LAGTPPPGTT-VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGE 2061
Query: 1349 PKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI-------PLWFDITGGNYDSH 1401
+ F + T+ E+ P G V P + P+ + I GN
Sbjct: 2062 AERGPR---FPRASSEATIRENAPP----GTPIVSPRAVHAGGTNGPITYSILSGNEKGT 2114
Query: 1402 FDVDKGTGTIIV--AKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTS 1459
F + TG I V A+ LD E L ++A G T + + + D ND+ P+F
Sbjct: 2115 FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRP 2174
Query: 1460 KYEVVIPEDTAPETEILQISA--VDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTS 1517
Y +PE E +LQ+ A +DQ ++ Y+L +S+ L F +DP TG++ T+
Sbjct: 2175 HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL--FHVDPTTGTITTT 2232
Query: 1518 EKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAV 1577
LD E + L +M D+ P A + V V DTND+ P ++ RV E A +
Sbjct: 2233 AILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALL 2291
Query: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637
GS + QVT D D G + Y + + F + G + LD Y L +
Sbjct: 2292 GSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQL 2349
Query: 1638 KATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS- 1696
A D + +T + V ++ +P F+ Y V L E GS + V+A + S
Sbjct: 2350 LAHDGPHEGRANLT---VLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
Query: 1697 ----VVYEIKDGNTGDAFDINPHSGTIIT---QKALDFETLPIYTLIIQGTNMA--GLST 1747
+ Y + + D F ++P++GT+ T AL + ++++ + G +
Sbjct: 2407 ANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAA 2464
Query: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKD-SNAL 1806
TV V LQD+ND+AP F + Y ++E S +LT + A DAD S+A
Sbjct: 2465 RATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-------LEATDADGSRSHAA 2517
Query: 1807 LVYHIVEPSVHTYFAIDS--------------STGAIHTVLSLDYEETSIFHFTVQVHDM 1852
+ Y I+ + F ++ + G + + LD+E + ++ TV D
Sbjct: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADR 2577
Query: 1853 GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFS 1912
G P + VTV V+D+ND PPVF + Y ++ T G +++ V A+DAD
Sbjct: 2578 GQPPQSS--VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHG 2635
Query: 1913 QLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASD--GRFAGLTSVKIN 1968
+ ++++ G+ F +D +G L + + + ++R++L V+A+D G L V I
Sbjct: 2636 LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIE 2695
Query: 1969 VKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINE--PLFYHILN----PDRR 2022
V++ + F ++ S V EN + + AI L Y +L P+ R
Sbjct: 2696 VQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGR 2755
Query: 2023 --FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPV 2080
F ++ ++G L PFD E E+F ++V + SA V V V ED+ D PV
Sbjct: 2756 EAFALNSSTGELRAR-VPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PV 2812
Query: 2081 FVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129
F+ ++ V GH + +V A D D G +G V Y L +F I
Sbjct: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGI 2861
Score = 459 bits (1181), Expect = e-128
Identities = 481/1837 (26%), Positives = 779/1837 (42%), Gaps = 183/1837 (9%)
Query: 76 SGDSENLFKAEEYILGDFCFLRIRTKGGNTAIL---NREVKDHYTLIVKALEKNTNVEAR 132
SG + L + + + D RI + G L +RE + Y L+V+ + + +
Sbjct: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
Query: 133 T-KVRVQVLDTNDLRPLFSPTSYS------VSLPENTAIRTSIARVSATDADIGTNGEFY 185
T V V VLD ND P F S + + +P+ T + + A D D G NG
Sbjct: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
Query: 186 YSFKDR-TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLT 244
Y+ +++F++HP SG ++ L E Y + + A D+G S S+ +L
Sbjct: 1254 YTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQG-----SPPRSASLQLL 1308
Query: 245 VHIEQANECAPVITAVTLSPSELDRDPAY---AIVTVDDCDQGANGDIASLSIV---AGD 298
V + P P +RDPA ++TV + G + AG
Sbjct: 1309 VQV------LPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGV 1362
Query: 299 LLQQFRTVRSFPGSKEYKVKAIGG-------IDWDSHPFGYNLTLQAKDKGTPPQFSSVK 351
+ V + + A G +D+++ P LT++A+ G + +
Sbjct: 1363 GALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAG--ARLL 1420
Query: 352 VIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA-----YSHLRY-VFKST 405
+ V F +D + E P + +A A S +RY + +
Sbjct: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE 1480
Query: 406 PGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTK--------VLVKVLGAN 457
P L+ TG +S + R+ L V +DR A+ V V N
Sbjct: 1481 PPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDEN 1540
Query: 458 SNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTG 517
N P F + + E+ P G + + A DPD GE V+Y +A+ F + TG
Sbjct: 1541 DNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTG 1599
Query: 518 AVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGT 577
A+S LD E + L + ASD G P R +VL T+++ ++ND P F++
Sbjct: 1600 ALSVVRPLDREQRAE-HVLTVVASDHGSPPRSATQVL-TVSVADVNDEAPTFQQQEYSVL 1657
Query: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
+ + G + T+ A D D Q G + FSL+P++GVL+ R+L +
Sbjct: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTY-GGVSSESFSLDPDTGVLTTLRAL-----DR 1711
Query: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
+ +T + + P ++TV +
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQLTHVTVRVA------------------------------- 1740
Query: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
VED N H P F S ++V E Q ++ + ++D D G NG+L Y +
Sbjct: 1741 -VED-------ENDHAPTFGSA-HLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL 1790
Query: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAND 817
G+ F++D+ +G + PLDRE + L I D G P +A LL V V+DAND
Sbjct: 1791 DGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDAND 1850
Query: 818 NPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGV 876
+ P F +Y VEV ED + ++Q++A D D G NGHVTY + T F ++ +G
Sbjct: 1851 HAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE 1910
Query: 877 VNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKV 936
+ A LDRE ++ + A D A P L +TV V +++ DVND+ PTF R+++
Sbjct: 1911 LRTAAALDREQCPSYTFSVSAVDGAAAGP-LSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
Query: 937 REDLPEGT----VIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFE 992
P + + L A D D G + + Y L VD +G +R+ +
Sbjct: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVAL 2029
Query: 993 KKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSL 1052
+ L + A D G+P + S+T + V + E P F + T++E+AP G+
Sbjct: 2030 GPRDRVLFIVATDLGRP-ARSATGVIIVGL--QGEAERGPRFPRASSEATIRENAPPGTP 2086
Query: 1053 VMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVI--ETSDRLDRESTSHYWLTVF 1110
+++ A +G I YSI G+ G F I TG I +++ LD E + L +
Sbjct: 2087 IVSPRAVHAGG-TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
Query: 1111 ATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS 1170
A G +F + + ++D NDNAP+ P Y + E+ P + ++Q+EA D D S
Sbjct: 2146 AESGGAF---AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS 2202
Query: 1171 NDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIA 1229
++ Y + + P +G F + P TG ITTT+ LDRE E L + TD GSP A
Sbjct: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTA-ILDREIWAETRLVLMATDRGSPALVGSA 2261
Query: 1230 RVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISY 1289
+ V ++D NDN+P Q +++R+ E E + V D D GP + Y
Sbjct: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSE-------IAQVTGNDVDSGP--VLWY 2311
Query: 1290 SIEDGNEHGKFFIEPKTGVVS---SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWI 1346
+ F + G VS F Y L + A D +++ T L +E +
Sbjct: 2312 VLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ-LQLLAHDGPHEGRANLTVL-VEDV 2369
Query: 1347 SKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV--EPPGIPLWFDITGGNYDSHFDV 1404
+ P +F +S + ++E P I +S G + F V
Sbjct: 2370 NDNAP-----AFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSV 2424
Query: 1405 DKGTG---TIIVAKPLDAEQKSNYNLTVEATD----GTTTILTQVFIKVIDTNDHRPQFS 1457
D G TI+ L + ++ +EA D G T V +++ D NDH P F+
Sbjct: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARAT-VHVQLQDQNDHAPSFT 2483
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDP-------- 1509
S Y V + ED P + +L + A D D S + F+L+P
Sbjct: 2484 LSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGES 2543
Query: 1510 ------ATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFT 1563
A G L E LD E++ Q+ LTV D+ P + + + V V D ND+ P FT
Sbjct: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT 2603
Query: 1564 ASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAK 1623
+SY+ V E VG+ +L V A D D G + V +++ SG+ F +D G+++ A
Sbjct: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAH 2663
Query: 1624 ELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIG 1683
LD QA + L+V+A D + + V I V ++ P F S ++E G
Sbjct: 2664 ALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPG 2722
Query: 1684 SFVGMV-----TAHSQSSVVYEIKDGNTG----DAFDINPHSGTIITQKALDFETLPIYT 1734
+ V + A + + Y + + G +AF +N +G + + D+E +
Sbjct: 2723 TLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFR 2782
Query: 1735 LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL-V 1793
L++ + LS + TV V + E++ PVF+ + + E A R L
Sbjct: 2783 LLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGAR--------RGHSLGH 2834
Query: 1794 IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIH 1830
++A D D ++ L++Y + S YF I+ +TGA++
Sbjct: 2835 VQATDEDGGADGLVLYSLATSS--PYFGINQTTGALY 2869
Score = 303 bits (777), Expect = 2e-81
Identities = 250/819 (30%), Positives = 379/819 (46%), Gaps = 46/819 (5%)
Query: 2818 IVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDH 2877
I E P G+ + I A +GT +MY + + V AI+ +G + T + LD
Sbjct: 51 IDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
Query: 2878 EKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVI 2937
E+RD Y+ V D +T V V V D+ND P F V E G
Sbjct: 110 EQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRY 162
Query: 2938 AILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE-----WKVYVKKPLDREKRDNY 2992
+ DAD+ + Q Y ++G F +ET ++ V LDRE R +Y
Sbjct: 163 PLEPARDADAGRLGTQ-GYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
Query: 2993 LLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATD 3049
+L + A DG ++A+++V +LD ND++P ++ Y + E + PG ++Q+ A+D
Sbjct: 222 MLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASD 281
Query: 3050 ADIRSNAEITYTL---LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG-- 3104
AD N +TY + G F ++ TG L+ PLD E++ V+ L+V+A DGG
Sbjct: 282 ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP 341
Query: 3105 RFCQASIVLTLEDVNDNAPE----FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKI 3160
A + + + D NDN P F + + V E PG L+ R+ +D D G +
Sbjct: 342 ELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHV 401
Query: 3161 LYSLIDSADGQFSINELSGIIQL---EKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVI 3217
SL + +G F+++ +I L + LDRE + Y L + A D G P L A +
Sbjct: 402 NVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSP-PLRAEAAFV 459
Query: 3218 VSVLDINDNPPVFEYREY-GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHG 3276
+ V D+NDN P F+ + Y + E L G+ V++V A D N ++TYS+ G
Sbjct: 460 LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH 519
Query: 3277 KFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
FSID +G + +LDYE + L V ATDGG P L+ ATV+V + D+NDN P F
Sbjct: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
Query: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIID--GNQGS-SFTIDPVRGEVK 3393
+ Y + E + V A DAD + YS+ G+ GS F ID G+V
Sbjct: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVC 639
Query: 3394 VTKLLDRET-ISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQEN 3452
T+ LDR+ S + TV A D G + V + +SD NDN P F Y+ I
Sbjct: 640 TTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQ 697
Query: 3453 KPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTSS-AIKRKEKDHY 3511
P G +VL+L D D +G + I+ GN F ++ Q LLT + + R+
Sbjct: 698 SPPGTAVLRLRAHDPDQGSHG-RLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVV 756
Query: 3512 LLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHA-T 3570
L++ D G Q +DI ++ + PP L+ + + G +G + A
Sbjct: 757 QLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN 816
Query: 3571 DQDVYDTLTYSL---DPQMDNLFSVSSTGGKLIAHKKLD 3606
+T SL DP+ LFS+ + G L + LD
Sbjct: 817 PPGRLAPVTLSLSGGDPR--GLFSLDAVSGLLQTLRPLD 853
Score = 139 bits (349), Expect = 8e-32
Identities = 148/554 (26%), Positives = 239/554 (43%), Gaps = 47/554 (8%)
Query: 105 TAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAI 164
T L+ E D Y L + L + E R + V V D ND P FS + Y V L E+T
Sbjct: 2334 TGPLDFEQCDRYQL--QLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391
Query: 165 RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG---VIVLTGRLDYLETKLYEME 221
++I VSATD D G NG Y D F++ P +G IV T L + + ++
Sbjct: 2392 GSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVV 2451
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--VTLSPSELDRDPAYAIVTVD 279
+ A D +G+ G ++ A + V ++ N+ AP T ++ +E D P ++T++
Sbjct: 2452 LEARD-----HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE-DLPPGSTLLTLE 2505
Query: 280 --DCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYK---VKAIG------GIDWDSH 328
D D + SI++G+ + F+ + E +A+G +D++S
Sbjct: 2506 ATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESL 2565
Query: 329 PFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVM 388
YNLT+ A D+G PPQ SSV + VT P F + YR + E P ++
Sbjct: 2566 T-QYNLTVAAADRGQPPQ-SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623
Query: 389 VKAIPA----YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD-- 442
V+A A + +R+ S F L+ ++G + + + + A +L V +D
Sbjct: 2624 VEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPA 2683
Query: 443 --RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTY 500
A V ++V N + P F + EN P GT V +L A+D D G G + Y
Sbjct: 2684 GAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRY 2743
Query: 501 SIANLNHVP-----FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLA 555
S+ P FA++ TG + DYE + L + A+D G V
Sbjct: 2744 SLLEAGPGPEGREAFALNSSTGELRARVPFDYE-HTESFRLLVGAADAG---NLSASVTV 2799
Query: 556 TITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNELD 613
++ + ++ P+F +P G + V A D D LV Y + +
Sbjct: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS--P 2857
Query: 614 FFSLNPNSGVLSLK 627
+F +N +G L L+
Sbjct: 2858 YFGINQTTGALYLR 2871
Score = 67.0 bits (162), Expect = 4e-10
Identities = 70/270 (25%), Positives = 110/270 (40%), Gaps = 27/270 (10%)
Query: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
+ P FT Y VTV E++ + H V+ P VR+ + SGD LF+ +
Sbjct: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLH-VEASDADPGPHGLVRFTVSSGDPSGLFELD 2653
Query: 87 EYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLR 146
E LR+ L+ E + + L+V+A + A V ++V D ND
Sbjct: 2654 E----SSGTLRL------AHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHG 2703
Query: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF------KDRTDMFAIHPT 200
P F S S+ EN T + + A D D G G YS + + FA++ +
Sbjct: 2704 PAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSS 2763
Query: 201 SGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAV 260
+G + DY T+ + + + AAD G +S+ ++V + +E PV A
Sbjct: 2764 TGELRARVPFDYEHTESFRLLVGAADAG-------NLSASVTVSVLVTGEDEYDPVFLAP 2816
Query: 261 TLS---PSELDRDPAYAIVTVDDCDQGANG 287
P R + V D D GA+G
Sbjct: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADG 2846
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 899 bits (2324), Expect = 0.0
Identities = 832/2924 (28%), Positives = 1356/2924 (46%), Gaps = 246/2924 (8%)
Query: 722 TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLD 781
T + + E+ PVGSSV + + D+D N LV+ VSG F ++ +TG++ + PLD
Sbjct: 38 TYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
Query: 782 RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841
RET ++T+ +V D Q R +++ V D NDN P F + Y V + E+ V + I
Sbjct: 95 RETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
Query: 842 IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA 901
V ATD DLG G V YS + F+IDS G+V + R LD E + L + A DQ
Sbjct: 152 FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
Query: 902 REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQ 961
+ P L + + + + DV D P FI Y + E P GT + + A D D G+
Sbjct: 212 KTRP-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
Query: 962 VRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEK---KQVYNLTVRA---KDKGKPVSLSS 1014
+ Y+++ + F +D +SG + + LD E + LTV+ D P +
Sbjct: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
Query: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG-SLVMTVSAHDEDARRDGEIRYSI 1073
T + V+D+N+N P F+S + E A VG +L + + D+D + +
Sbjct: 331 TTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
Query: 1074 -RDGSGVGVFKI------GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126
G+ F I G+ I + LD E+ Y +FA ++ V + ++
Sbjct: 389 YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVK 447
Query: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGF 1186
I + + NDN P S+P+Y + EN SV+ + A D D+ + ++ Y S +P
Sbjct: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR- 505
Query: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL 1246
FS+ TGLI +R LD E L + D G + T RV + +LD NDN P F
Sbjct: 506 FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQ 562
Query: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF---IE 1303
+ Y L E E + L + ATD+D PN +I+YSI + G +F +
Sbjct: 563 KDAYVGALRENEPSVTQ-------LVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
Query: 1304 PKTGVVSSKR----FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFE 1359
GV+S R + L++ A+D G P +ST + IE + + P +F
Sbjct: 616 EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE---NDNPPTFS 672
Query: 1360 ESFFTFTVMESDPVAHMIGVI-------SVEPPGIPLWFDITGGNYDSHFDVDKGTGTII 1412
+ + +V+E+ + + S E + + + G + F ++ +G I
Sbjct: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEIT 729
Query: 1413 VAKPLDAEQKSNYNLTVEATDG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPE 1467
LD E KS Y L V A DG T + V I ++D ND+ P + + Y + + E
Sbjct: 730 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 789
Query: 1468 DTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKL----- 1520
T P++++ + AVD D E L+Y++Q K + L+ TG + T+ +
Sbjct: 790 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-----KFYSLNSTTGKIRTTHAMLDREN 844
Query: 1521 --DHEAVHQHTLTVMVRDQDVPVKR--NFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576
HEA + V V D P + + A + VN+ D ND+ P F + V E
Sbjct: 845 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIP 904
Query: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
G + QV A+D D+G N V Y + G F+I+ G + T ELDR AEY L
Sbjct: 905 AGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR 964
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS--- 1693
V A+D G+P S +++ I V ++ +P F Y+V +SE V V +
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
Query: 1694 --QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL----ST 1747
+ + Y I GN F + + T LD ET Y LI++ + + +
Sbjct: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTG 1084
Query: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807
TV V + D NDN P+F+Q+ Y + E + + + L ++A DAD+ +
Sbjct: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPED-------IPEGHSILQLKATDADEGEFGRV 1137
Query: 1808 VYHIVEPSVHTYFAIDSSTGAI-HTVLSLDYEETSIFHFTVQV--HDMGTPRLFAEYAAN 1864
Y I+ + F I S G + LD E S V+ HD+G R +
Sbjct: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR----SSVR 1193
Query: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYK-GVKVITVNATDADSSAFSQLIYSITEGNI 1923
V V+V DIND PVF + Y L T G VI V ATD DS + Y I G
Sbjct: 1194 VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE 1253
Query: 1924 GEKFSMDYKTGALTVQN--TTQLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978
G KF +D TG + N + ++ Y + V A+D G SV I + + ++
Sbjct: 1254 G-KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQ 1312
Query: 1979 FTQDVYSAVVKENSTEAETLAVITAIG-NPINEPLF----YHILNPDRRFKISRTSGVLS 2033
F+ Y A + EN + + A + +N+ + Y FKI +GV++
Sbjct: 1313 FSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVIT 1372
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV-VKV 2092
G DRE+ + + + V V ++ P + V V + V D+NDN+P F AV +
Sbjct: 1373 VQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430
Query: 2093 DTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQI----GPLGEISLKKQFELDTL 2146
D VG + V A D D+G NG+V + L + F+I +GE+ + + + + L
Sbjct: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
Query: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF-YSAEIAESIQVHSPVVH 2203
+ Y++ VVA D G P + I+ +T++ N PV E PF Y+ + E++ + VV
Sbjct: 1491 D-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549
Query: 2204 VQANSPE-GLK--VFYSITDGDPFSQFTINFNTGVINV-IAPLDFEAHPAYKLSIRATDS 2259
V+A + G+ + Y IT+G+ F ++ +G I AP D E Y L D
Sbjct: 1550 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE 1609
Query: 2260 LT---GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEA-SVIGTSVVQVRATDSDSEPN 2315
T A V+V I+ D NDN P+F Q Y V L E + TS++ ++A D D PN
Sbjct: 1610 GTPTLSATTHVYVTIV--DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
Query: 2316 RGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR-QHTIFVRAVDGGMPTLS--- 2371
++Y + + + F +D G+I+ + LDYE S ++T+ V A D P LS
Sbjct: 1668 GTVTYAIVAGNIV--NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD-QCPILSHRL 1724
Query: 2372 -SDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYDADSSDIDKLQYS 2428
S V V+V D+NDN P F + YE ++E P G V A+D DS +++YS
Sbjct: 1725 TSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYS 1782
Query: 2429 ILSGNDHKHFVIDSATGIITLS---NLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTV 2482
I+ G+ FVI G++ + L R + FY+L + D S+ V + V
Sbjct: 1783 IMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTICARDRGMPPLSSTMLVGIRV 1841
Query: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542
+ N + P L + ++EN+P+ + V V +D DSG +T++I + F+I
Sbjct: 1842 LDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFI 1901
Query: 2543 NERGQIFTLEK-LDRETPAEKVISVRLMAKDAGGKVA---FCTVNVILTDDNDNAPQFRA 2598
N I T+ + LDRE E +++ + ++A + + + L+D+NDN P F
Sbjct: 1902 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
Query: 2599 TKYEVNIGSSAAKGTSVV----KVLASDADEGSNADITYAIEADSESVKENLEINKLSGV 2654
+ Y+ + ++ GT + +LA DAD+ A +TY + + +IN +GV
Sbjct: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGL---FDINSSTGV 2018
Query: 2655 ITTKESLIGLENEFFT-----FFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYT 2709
+T + +I ++ E F+ + A D G + + +L + IL P FS T
Sbjct: 2019 VTVRSGVI-IDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLT 2075
Query: 2710 FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKL-E 2763
+ E+ P G + + A +G ++Y + E+ + F+I +G +++
Sbjct: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTGVIRVGN 2129
Query: 2764 KSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823
++D E + Y+ +++A + + + V+I + D ND+ P F + ++E+
Sbjct: 2130 ATIDREEQESYRLTVVA-TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
Query: 2824 GGSRVIQIRASDADSGTNGQVMYSL-------DQSQSVEVIE-SFAINMETGWITTLKEL 2875
G+ + I A D D N ++ Y + D + V E +FA+N+ TG + +
Sbjct: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
Query: 2876 DHEKRDNYQIKVVASDHGEKIQLSSTAI----VDVTVTDVNDSPPRFT---AEIYKGTVS 2928
+ E Y++ + D+ + S ++ + V V DVND+ P+F Y +
Sbjct: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
Query: 2929 EDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREK 2988
E G + ++ D D + +N VTY + P G +E + KV + +D E+
Sbjct: 2307 EGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEE 2364
Query: 2989 RDNYLLTITATDGTFSSKAI---VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
T+ A+D +A V ++++D NDN+P+ ++ Y + + EDV G +I+ +
Sbjct: 2365 VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTV 2424
Query: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG- 3104
+ATDAD + A I Y+ LG G KF +NP TG++ + LDRE++ Y L A D G
Sbjct: 2425 TATDADSGNFALIEYS-LGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGD 2483
Query: 3105 -----RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRK 3159
R +V+ + DVND P+FS ++ +V+EN GT + + ATD D G N +
Sbjct: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGE 2543
Query: 3160 ILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVS 3219
+ YSL F ++ SG++ ++PL + ++L++ A D G P L T ++V
Sbjct: 2544 LTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEP-PLWGTTMLLVE 2600
Query: 3220 VLDINDNPPVFEYREYGAT--VSEDILVGTEVLQVYAASRDIEANAEITYSII--SGNEH 3275
V+D+NDN PVF G + E+I + + V +VYA +D N + YS + +GN
Sbjct: 2601 VIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2660
Query: 3276 GK-FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP-SLSDVATVNVNVTDINDNTP 3333
+ F ID +G + + LD ES Y L + A+D G P + + V + DI+DN P
Sbjct: 2661 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2720
Query: 3334 VF------SQDTYTTVISEDAVLEQSVITVM-ADDADGPSNSHIHYSIIDGNQGSSFTID 3386
+F S + E + V V A DAD N+ ++Y I GN+ +F +
Sbjct: 2721 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ 2780
Query: 3387 PVRGEVKVTKLLDRETISGYTLTVQASDNGS--PPRVNTTT-----------VNIDVSDV 3433
P G + V + LDRE + ++ V+AS N S PPR + T V + + D+
Sbjct: 2781 P-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
Query: 3434 NDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFF 3477
ND P F++ Y+ + + VG ++Q++ D D +N F+
Sbjct: 2840 NDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFY 2883
Score = 871 bits (2250), Expect = 0.0
Identities = 844/2937 (28%), Positives = 1341/2937 (45%), Gaps = 239/2937 (8%)
Query: 804 AWRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYS 860
AW L+ + N F +F + +SED V S + Q+ A D D P + +
Sbjct: 12 AWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFG 68
Query: 861 IVTDTDT--FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
+ + + F+++ TGVV + +PLDRE + E +++ D Q T V + +
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDH-----QGVITRKVNIQVG 123
Query: 919 DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978
DVNDN PTF Y V++ E+ P GT I + A DPDLG G V YS + F +D
Sbjct: 124 DVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDS 182
Query: 979 LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFV 1038
G V ++++LD+E Q Y LTV A D+ K LS+ + + + DV + P+F +
Sbjct: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM--DPIFINLP 240
Query: 1039 EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098
+ E +P G+ V ++A D+D R I Y+I G+ +F + +GV+ + LD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Query: 1099 REST--SH-YWLTVFAT----DQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151
RE+ SH + LTV T D+ + I V D+NDNAP+ + Y I E
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
Query: 1152 SPKDVSV-VQIEAFDPDSSSNDKLMYKI-TSGNPQGFFSIHP-----KTGLITTTSRKLD 1204
+ ++ + I+ D D + M+++ GN F I P K + + LD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRER 1264
E D + ++ ++ P A+V + +++ENDN+P F Q Y I L E
Sbjct: 421 YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTS- 478
Query: 1265 NARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-- 1322
+ V+ATD D G E+SY D + +F ++ TG++ A +Y++
Sbjct: 479 ------VLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIM---LIARLDYELIQ 527
Query: 1323 ---LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDP-VAHMIG 1378
L+I A D G + + R+++ ++ P+ F++ + + E++P V ++
Sbjct: 528 RFTLTIIARDGGGEETTGRVRINVLDVNDNVPT-----FQKDAYVGALRENEPSVTQLVR 582
Query: 1379 VISVE---PPGIPLWFDITGGN-YDSHFDVD--KGTGTIIVAKPLDAEQKSN--YNLTVE 1430
+ + + PP + + I + + S+FD+ +G G I V++PLD EQ SN LTV
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
Query: 1431 ATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487
A D L V I+V D ND+ P FS Y V + E+ +L ++A D D
Sbjct: 643 AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
Query: 1488 K-----LIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVP-- 1540
+ +IY+L+ S +FR++ +G + T+ LD E ++ L V D V
Sbjct: 703 EYGQESIIYSLEGST------QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 1541 VKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYS 1600
K A + + + D ND+ P + + Y + E S V V A+D D G+N ++YS
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
Query: 1601 IESGNIGNSFMIDPVLGSIKTAKE-LDRSNQAEYD------LMVKATDKGSPPMSEITSV 1653
I+ N + ++ G I+T LDR N ++ ++V TD G PP+ +S
Sbjct: 817 IQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 1654 RIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNT 1706
+FV + D + P F + + E+ E + G + V A V Y + G
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
Query: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL---STNTTVLVHLQDENDNAP 1763
F IN SG ++T LD E + Y L + ++ AG S+ +T+ +H+ D ND P
Sbjct: 935 RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETP 993
Query: 1764 VFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAID 1823
F A Y +SE V+ + D D NA L Y I +V F++
Sbjct: 994 TFFPAVYNVSVSEDVPREFRVVW-------LNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
Query: 1824 SSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPL 1883
+ TV+ LD E T+ + ++ D G A V V V+D+ND P+F +
Sbjct: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
Query: 1884 YEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQ 1943
YEAS+ +G ++ + ATDAD F ++ Y I GN G F + G L
Sbjct: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
Query: 1944 LRSR---YELTVRASD---GRFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAE 1996
R R + L V A + G V + V++ + FTQ YS + ++E +
Sbjct: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT 1226
Query: 1997 TLAVITAIGNPINEP--LFYHILN-PDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEV 2053
++ V+ A + + Y IL+ + +F+I ++G++ T D E + ++ + V
Sbjct: 1227 SVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSA 1285
Query: 2054 TEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRN 2113
T++ P V + + ++ D A F N Y A + + +G I V A D+
Sbjct: 1286 TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ 1345
Query: 2114 GEVH---YYLKEHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVI 2169
Y + F+I + G I+++ + + Y +TVVA DGG P + V
Sbjct: 1346 ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREK-GDFYTLTVVADDGG-PKVDSTVK 1403
Query: 2170 VPITVM--NKAMPVFEKPFYSA-EIAESIQVHSPVVHVQANSPEGL---KVFYSITDGD- 2222
V ITV+ N P F+ SA I E V V V+A P+ +V +S+ G+
Sbjct: 1404 VYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI 1463
Query: 2223 --PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFV-DIIVDDINDN 2279
F T N + G + V PLD E Y L + A+D T + + + + DINDN
Sbjct: 1464 AGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDN 1523
Query: 2280 PPVFAQQ-SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMF-GNHSKSHDHFHVDS 2337
PPV Y V+++E GT+VVQVRATD D N +SY + GN + F +D
Sbjct: 1524 PPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDR 1580
Query: 2338 STGLISLLRTL-DYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYE 2396
+G I+ D E+ + + D G PTLS+ V V + D NDN P+F+Q YE
Sbjct: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
Query: 2397 ARISEHAPH-GHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN-LHR 2454
+ E + ++A D D + Y+I++GN F ID G+IT + L
Sbjct: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
Query: 2455 HALKPFYSLNLSVSDGV------FRSSTQVHVTVIGGNLHSPAFLQN-EYEVELAENAPL 2507
Y+L ++ +D S+T V V V N + P F ++ E E+ E P
Sbjct: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759
Query: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVI 2564
V D DSG G V Y I++ F I+ + + K LDRET A
Sbjct: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIA--FY 1817
Query: 2565 SVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASD 2622
++ + A+D G T V + + D NDN P + I ++ + V VLASD
Sbjct: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
Query: 2623 ADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP- 2681
AD G NA +T+ I A + + IN +G++T L + + DN
Sbjct: 1878 ADSGCNARLTFNITAGNR--ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENP 1935
Query: 2682 --SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR----AEHSGTVLY 2735
++ L+ + + P F++ Y V E+ P GT + ++ A + +Y
Sbjct: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
Query: 2736 SLVKGNTPESNRDESFVIDRQSGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASV 2793
++V + + F I+ +G + + +D E +L +D + ++
Sbjct: 1996 AVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL-LAEDIGLLNSTA 2053
Query: 2794 DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQS 2853
+ I + D NDN P F + ++EN P G V+Q+ A+D DSG NG+++Y ++
Sbjct: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
Query: 2854 VEVIESFAINMETGWITTLKE-LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVN 2912
+ F I++ TG I +D E++++Y++ VVA+D G + LS TAIV + + D+N
Sbjct: 2114 ----DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGT-VPLSGTAIVTILIDDIN 2168
Query: 2913 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG-----------G 2961
DS P F I +V E G VIA ++ D D +N ++ Y I G
Sbjct: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD---LNPKLEYHIVGIVAKDDTDRLVP 2225
Query: 2962 DPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS--------SKAIVEVKV 3013
+ FAV N V VK P++RE Y +T++ D A + V V
Sbjct: 2226 NQEDAFAVNI--NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
Query: 3014 LDANDNSPVCEK---TLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKF 3070
LD NDN+P + T Y + I E PG ++ ++A D D N +TYTLL +
Sbjct: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGY 2343
Query: 3071 KLNPDT--GELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFS 3126
D+ G++ + +D EE + VRA+D G R + + L + D+NDN P F
Sbjct: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
Query: 3127 ADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKP 3186
Y VFE+ GT++ V ATDAD+G I YSL D + +F+IN +G I +
Sbjct: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSS 2462
Query: 3187 LDRELQAVYTLSLKAVDQG---LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243
LDRE + Y L+ A D R + V++ VLD+ND P F ++ +V E+
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
Query: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303
GT V+ + A +D N E+TYS+ G F +D +G V L +S ++ L
Sbjct: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
Query: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV--ISEDAVLEQSVITVMADD 3361
TV ATDGG P L + V V D+NDN PVF + T+ I E+ L +V V A D
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 3362 ADGPSNSHIHYSIID--GNQG-SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSP 3418
D N + YS + GN+ F IDP+ G ++ + LDRE+ + Y+L + ASD G P
Sbjct: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
Query: 3419 -PRVNTTTVNIDVSDVNDNAPVFSRG-----NYSVI-IQENKPVGFSVLQLV-VTDEDSS 3470
P + + + D++DN P+F R Y ++ + E+ P G V + D D
Sbjct: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
Query: 3471 HNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADN--------GK 3522
N ++F I GN+EK F + P G LL + R+ + + VK + N
Sbjct: 2760 PNAIVYYF-IAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
Query: 3523 PQL---SSLTYIDIRVIEESI--YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV 3574
P L + LT ++RV+ E I PP E + + G + ++ A D D+
Sbjct: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADI 2875
Score = 871 bits (2250), Expect = 0.0
Identities = 826/2962 (27%), Positives = 1343/2962 (45%), Gaps = 281/2962 (9%)
Query: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
I D VG +T + A D D LV + + FF++ P++GV+ L++ L K
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDPLV-FGVSGEEASRFFAVEPDTGVVWLRQPL--DRETK 98
Query: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
F ++ + +D + T + VN+Q +
Sbjct: 99 SEF-TVEFSVSDHQGVIT------------RKVNIQVGD--------------------- 124
Query: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
VN + P F + P +++ EN PVG+ + +N+TD D G G ++Y+
Sbjct: 125 -----------VNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ 172
Query: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKY--TLNITVYDLGIPQKAAWRLLHVVVVDA 815
++ F ID G++ ++ LD ETT Y T+N T D P L +++ D
Sbjct: 173 PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLA-IIITDV 229
Query: 816 NDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSV 873
D P F+ Y + E + + + A D+D G + Y+IV+ F++D +
Sbjct: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI 289
Query: 874 TGVVNIARPLDRE---LQHEHSLKIEARDQAREEPQLFSTVVV--KVSLEDVNDNPPTFI 928
+GV+ + LDRE H L ++ + + +TV + + D+NDN P F
Sbjct: 290 SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN 349
Query: 929 PPNYRVKVREDLPEGTVI-MWLEAHDPD--LGQSGQVRYSLLDHGEGNFDVD------KL 979
Y V + E G + ++++ D D LG + L+ + +F + K
Sbjct: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA 409
Query: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
+R+ LD+E Y+ + A + Y +V++ +NEN + P+FS +
Sbjct: 410 DIRIRVAIPLDYETVDRYDFDLFANESVP----DHVGYAKVKITLINENDNRPIFSQPLY 465
Query: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDR 1099
++ E+ VG+ V+TV A D DA GE+ Y D F + ++TG+I RLD
Sbjct: 466 NISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDY 523
Query: 1100 ESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV 1159
E + LT+ A D G + + I V DVNDN P + Y + EN P +V
Sbjct: 524 ELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
Query: 1160 QIEAFDPDSSSNDKLMYKITSGNPQGFF---SIHPKTGLITTTSRKLDREQQDEHILEVT 1216
++ A D DS N+++ Y I S + G + S++ G+I+ SR LD EQ ++ +T
Sbjct: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLT 640
Query: 1217 VT--DNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV 1274
V D G+PP ++ V +++ DENDN P F + Y + + E + +
Sbjct: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT-------VLFL 693
Query: 1275 IATDKD---EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF---SAAGEYDILSIKAV 1328
ATD D E I YS+E + F I ++G +++ EY IL ++AV
Sbjct: 694 NATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEY-ILIVRAV 749
Query: 1329 DNG--RPQKSSTTRLHIEWIS--------KPKP---SLEPISFEESFFTFTVMESDPVAH 1375
D G QK+ ++I + K P +L ++ +S T TV+ DP
Sbjct: 750 DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT-TVVAVDPDLG 808
Query: 1376 MIG--VISVEPPGIPLWFDITGGNY-DSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEAT 1432
G V S++PP + T G +H +D+ P E + + V T
Sbjct: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDR-------ENPDPHEAELMRKIVVSVT 861
Query: 1433 DG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487
D T VF+ ++D ND+ P F + + E I Q+ A+D DE
Sbjct: 862 DCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEG- 920
Query: 1488 KLIYTLQSSRDPLSLKK--FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNF 1545
+ L S R P+ + + F ++ ++G + T+ +LD E + ++ L V+ D P K +
Sbjct: 921 --LNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
Query: 1546 ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGN 1605
+ + ++V D ND P F + Y V E V+ + D D G NAE+ Y I GN
Sbjct: 979 STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
Query: 1606 IGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD--NA 1663
+ F + ++T LDR A Y L+++A D G + +FVT+ D +
Sbjct: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 1664 SPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGT 1718
P F Y + E + G + + A V Y I GN G+ F I+ +G
Sbjct: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL 1158
Query: 1719 IIT-QKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQAEYTGL-I 1774
++ + LD E + LI++ N + + ++ V+V+++D ND APVF Q +Y+ L +
Sbjct: 1159 LMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGL 1218
Query: 1775 SESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS 1834
E+A I + V+ V++A D D L+ Y I+ F ID STG I TV
Sbjct: 1219 RETAGIGTSVI-------VVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNY 1270
Query: 1835 LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYK 1894
LDYE + + V D P F + +V + +++ D F+ YEA++L
Sbjct: 1271 LDYETKTSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLAL 1328
Query: 1895 GVKVITVNATDADSSAFSQLIY---SITEGNIGEKFSMDYKTGALTVQNTTQLRSR--YE 1949
G +++ V A D+ +Q+ Y + T F +D TG +TVQ Y
Sbjct: 1329 GTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
Query: 1950 LTVRASDG--RFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAETLAVITAIGN 2006
LTV A DG + V I V + ++ +F SAV + E+ + +A + A
Sbjct: 1387 LTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDP 1446
Query: 2007 PI--NEPLFYHIL--NPDRRFKISRTSGVLSTT--GTPFDREQQEAFDVVVEVTEEHKPS 2060
N + + + N F+I T+ + P DRE+ + + + V ++ P
Sbjct: 1447 DAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPP 1506
Query: 2061 AVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH--VIRYVTAVDRDSGRNGEVHY 2118
+++V + D NDN PV + P+ V V+ VG + V A DRD G N + Y
Sbjct: 1507 RKKDHILQVTILDINDNPPV-IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSY 1565
Query: 2119 YLKEHHEH--FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM 2175
Y+ E ++ F++ + GEI+ + Y + +D G P SA V +T++
Sbjct: 1566 YITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIV 1625
Query: 2176 --NKAMPVFEKPFYSAEIAESIQ-VHSPVVHVQA----NSPEGLKVFYSITDGDPFSQFT 2228
N P+F++P Y + E +++ ++ +QA P G V Y+I G+ + F
Sbjct: 1626 DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFR 1684
Query: 2229 INFNTGVINVIAPLDFE-AHPAYKLSIRATDSLT----GAHAEVFVDIIVDDINDNPPVF 2283
I+ + GVI LD+E +H Y L + ATD + V + V+DINDN P F
Sbjct: 1685 IDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
Query: 2284 AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLIS 2343
+ G V A D DS PN + Y + F + G++
Sbjct: 1745 PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE--FVISPVEGVLR 1802
Query: 2344 LLRT--LDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
+ + LD E + + + A D GMP LSS ++V + V D+NDN P+ ISE
Sbjct: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
Query: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFY 2461
++P FV V A DADS +L ++I +GN + F I++ TGI+T++ P Y
Sbjct: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
Query: 2462 SLNLSVSDG------VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHT----LV 2511
L +SV D R + + + N + P F ++ Y+ E+ EN+P T L
Sbjct: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
Query: 2512 MEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVISVRL 2568
+ D D IY VTY ++ F IN + T+ +DRE + ++ + L
Sbjct: 1983 GPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
Query: 2569 MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSN 2628
+A+D G + + + + DDNDN P F V++ + G SV++V A+D D G N
Sbjct: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
Query: 2629 ADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN-EFFTFFVRAVDNGSPSKESVV 2687
++ Y IEA ++ + I+ ++GVI + I E E + V A D G+
Sbjct: 2102 GELVYRIEAGAQ---DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158
Query: 2688 LVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVLYSLV----KG 2740
+V + I P+F P T +V E GT I I A + + + Y +V K
Sbjct: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218
Query: 2741 NTPE--SNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDD----HEMVASVD 2794
+T N++++F ++ +G + ++ ++ E Y+ ++ D V +
Sbjct: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
Query: 2795 VSIQVKDANDNSPVFES---SPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQS 2851
+++ V D NDN+P F+ + Y I+E G+ +I + A D D G NG V Y+L
Sbjct: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL--- 2335
Query: 2852 QSVEVIESFAINME---TGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908
++++ + +E G + + +D+E+ V ASD+G + + + + +
Sbjct: 2336 --LDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVY-LEI 2392
Query: 2909 TDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
D+ND+ P F Y+ V ED P G +I ++ TDADS + Y + GD +FA
Sbjct: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFA 2449
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD--GTFSSK-----AIVEVKVLDANDNSP 3021
+ + +YV LDREK+D+Y+LT A D G +S V ++VLD ND P
Sbjct: 2450 INPTTGD--IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
Query: 3022 VCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKT 3081
K +S ++ E+ G ++ + ATD D N E+TY+L G G E F ++ D+G + T
Sbjct: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT 2567
Query: 3082 STPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYA--ITVFEN 3137
PL E+ + L V ATDGG + +L +E DVNDN P F P + + E
Sbjct: 2568 QRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
Query: 3138 TEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQA 3193
+ + V ATD D GLN + YS + +A + F I+ +SG+IQ + LDRE QA
Sbjct: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
Query: 3194 VYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGA------TVSEDILVGT 3247
VY+L L A D G P + V++ DI+DN P+F G+ TV E GT
Sbjct: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
Query: 3248 EVLQVYAA-SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVE 3306
V V A D NA + Y I +GNE F + G + ++ +LD E + V+
Sbjct: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVK 2804
Query: 3307 ATD--------GGTPSLSDVAT-----VNVNVTDINDNTPVFSQDTYTTVISEDAVLEQS 3353
A+ G +P+L VA V V + DIND P F++ YT ++ DA +
Sbjct: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
Query: 3354 VITVMADDADGPSNSHIHYSII 3375
+I V+A DAD +NS + YSI+
Sbjct: 2865 LIQVLALDADIGNNSLVFYSIL 2886
Score = 853 bits (2204), Expect = 0.0
Identities = 852/3035 (28%), Positives = 1375/3035 (45%), Gaps = 306/3035 (10%)
Query: 438 VTTSDRKASTKVLVK-VLGANSNPPEFTQTAYKA--AFDENVPIGTTVMSLSAVDPDEGE 494
V TS A VL+ G + P FT + E+ P+G++V L A D D
Sbjct: 5 VATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD--- 61
Query: 495 NGYVTYSIANLNHVPF-AIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553
N + + ++ F A++ TG V + LD E +T+ SD R+V
Sbjct: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE-FTVEFSVSDHQGVITRKVN- 119
Query: 554 LATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNE 611
I + ++NDN P F IP + VG I V+A D D V Y + ++
Sbjct: 120 ---IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
Query: 612 LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVN 671
FF+++ G++++ R L + L + ATD + PL L N
Sbjct: 177 --FFAIDSARGIVTVIRELDY---ETTQAYQLTVNATDQDK-TRPL---------STLAN 221
Query: 672 LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP 731
L T V M + IF + LP + E+ P
Sbjct: 222 LAIIITDVQDM-----------------DPIFIN--------------LPYSTNIYEHSP 250
Query: 732 VGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET---TDKY 788
G++V + + D D G + Y + GN +S F +D +G+L + LDRE + +
Sbjct: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
Query: 789 TLNITVYDLG---IPQKAA-WRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--- 841
L + +L P A +++V+D NDN PEF Y V ++E +V +
Sbjct: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
Query: 842 IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGV-------VNIARPLDRELQHEHSLK 894
IQV D++LG N +V + I S T V + +A PLD E +
Sbjct: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
Query: 895 IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDP 954
+ A + P VK++L + NDN P F P Y + + E++ GT ++ + A D
Sbjct: 431 LFANESV---PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
Query: 955 DLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014
D G G+V Y D + F +DK +G + ++ +LD+E Q + LT+ A+D G +
Sbjct: 488 DAGTFGEVSYFFSDDPD-RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ET 543
Query: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
T V + V+DVN+N+ P F G ++E+ P + ++ + A DED+ + +I YSI
Sbjct: 544 TGRVRINVLDVNDNV--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
Query: 1075 DGSGVGVF---KIGEETGVIETSDRLDRESTSH--YWLTVFATDQGVVPLSSFIEIYIEV 1129
S G + + E GVI S LD E S+ +LTV A D G PL+S + + IEV
Sbjct: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
Query: 1130 EDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS---SNDKLMYKITSGNPQGF 1186
D NDN P S+P Y+ ++EN +V+ + A D D S + ++Y + G+ Q
Sbjct: 662 FDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ-- 718
Query: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNG--SPPKSTIARVIVKILDENDNKPQ 1244
F I+ ++G ITTTS LDRE + E+IL V D G K+ IA V + +LD NDN P
Sbjct: 719 FRINARSGEITTTSL-LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 1245 FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP 1304
+ Y I L E PD + V+A D D G N + YSI+ N+ + +
Sbjct: 778 WKDAPYYINLVEMTPPDSDVTT-------VVAVDPDLGENGTLVYSIQPPNKF--YSLNS 828
Query: 1305 KTGVVSSKRFSAAGEYDI---------LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
TG + + E + + D GRP +T+ + +++ +
Sbjct: 829 TTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDND 887
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG--------GNYDSHFDVDKG 1407
+F+ F V+E P GV + I L + G G F ++
Sbjct: 888 PTFQNLPFVAEVLEGIPA----GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSS 943
Query: 1408 TGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYEVV 1464
+G ++ LD E+ + Y L V A+D T + + + I V+D ND P F + Y V
Sbjct: 944 SGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
Query: 1465 IPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDH 1522
+ ED E ++ ++ D D +L Y + KF + + T LD
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVD---GKFSVGYRDAVVRTVVGLDR 1060
Query: 1523 EAVHQHTLTVMVRDQDVPVKRNF--ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSV 1580
E + L + D KR+ A + V V D ND+ P F SSY+ V E G
Sbjct: 1061 ETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHS 1120
Query: 1581 VLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSI-KTAKELDRSNQAEYDLMVKA 1639
+LQ+ A D D+G+ V Y I GN GN+F I G + + + LDR + + L+V+A
Sbjct: 1121 ILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA 1180
Query: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYS-VELSETVSIGSFVGMVTAHSQSS-- 1696
+ PM V ++V ++ +P FT ++YS + L ET IG+ V +V A + S
Sbjct: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
Query: 1697 ---VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTN--TTV 1751
V Y I G G F+I+ +G IIT LD+ET Y + + T+ A +V
Sbjct: 1241 GGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSV 1299
Query: 1752 LVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHI 1811
+ L +E D A F A Y I E+ ++ + ++ ++A D + ++
Sbjct: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVR-------VQAYSIDNLNQITYRFNA 1352
Query: 1812 -VEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
F ID+ TG I +D E+ + TV V D G P++ + V + V+
Sbjct: 1353 YTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKV--DSTVKVYITVL 1409
Query: 1871 DINDCPPVFAKPLYEA-SLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929
D ND P F A S+ G +V TV A D D+ + Q+++S+ GNI F +
Sbjct: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
Query: 1930 ---DYKTGALTVQNTTQLRS--RYELTVRASD--------GRFAGLTSVKIN----VKES 1972
+ G + V Y L V ASD +T + IN V ES
Sbjct: 1470 VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIES 1529
Query: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI--NEPLFYHIL--NPDRRFKISRT 2028
Y+ V EN + + A I N L Y+I N D F++ R
Sbjct: 1530 PFG--------YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRI 1581
Query: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088
SG ++T P DRE+Q + +V V +E P+ A V V + D+NDNAP+F P+Y
Sbjct: 1582 SGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYE 1640
Query: 2089 VVKVD--TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQIGP-LGEISLKKQFEL 2143
V+ + + + + A+D D G NG V Y + + F+I +G I+ K+ +
Sbjct: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
Query: 2144 DTLNKEYLVTVVAKD-----GGNPAFSAEVIVPITVMNKAMPVF----EKPFYSAEIAES 2194
+ + Y + V A D + V+V + +N +P F E PF E
Sbjct: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPG 1760
Query: 2195 IQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVI--APLDFEAHPAYKL 2252
+V + + H + + P G +V YSI DGDP +F I+ GV+ V LD E Y L
Sbjct: 1761 PRVWTFLAHDRDSGPNG-QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
Query: 2253 SIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSD 2311
+I A D + + + V I V DINDN PV +T+SE S + + V V A+D+D
Sbjct: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
Query: 2312 SEPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGM-PT 2369
S N +++ + GN ++ F ++++TG++++ R LD E+ ++ + + D P
Sbjct: 1880 SGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
Query: 2370 LSSDV--IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK----AYDADSSDID 2423
++ ++ + ++D NDN PLF + Y+A + E++P G +T + A DAD
Sbjct: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYA 1996
Query: 2424 KLQYSILSGNDHKHFVIDSATGIITLSN---LHRHALKP--FYSLNLSVSDGVFRSSTQV 2478
+ Y +L G F I+S+TG++T+ + + R A P L L+ G+ S+ +
Sbjct: 1997 VVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHL 2055
Query: 2479 HVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKD 2538
+T++ N + P F V L EN P V++V TD DSG+ G + Y I A+D
Sbjct: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
Query: 2539 RFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQF 2596
RF I+ + + + ++ + ++A D G T V +++ D ND+ P+F
Sbjct: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
Query: 2597 RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI-----EADSESVKENLE---- 2647
V++ SA GT + + A D D N + Y I + D++ + N E
Sbjct: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
Query: 2648 INKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLV-----YVKILPPEMQLPK 2702
+N +G + K + + + +DN S E V V V +L P+
Sbjct: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
Query: 2703 FSE---PFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVID 2754
F +Y + E GT + + A +G V Y+L+ P + E D
Sbjct: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE----D 2348
Query: 2755 RQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPY 2814
+G++ +++D+E W F++ A A + V +++ D NDN+P+F+ Y
Sbjct: 2349 SSAGKVIANRTVDYEEVHWLNFTVRAS-DNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
Query: 2815 EAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKE 2874
+ + E++P G+ ++ + A+DADSG + YSL +S FAIN TG I L
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES-----KFAINPTTGDIYVLSS 2462
Query: 2875 LDHEKRDNYQIKVVASDHGEKI---QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD 2931
LD EK+D+Y + +A D+ + + ++ V + V DVND P+F+ + +V E++
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
Query: 2932 PQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991
P G + + TD D E N ++TY + G G A + V ++PL + +
Sbjct: 2523 PAGTSVITMMATDQD-EGPNGELTYSLEGP---GVEAFHVDMDSGLVTTQRPL--QSYEK 2576
Query: 2992 YLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDT--IPEDVLPGKLIMQIS 3046
+ LT+ ATDG ++ V+V+D NDN PV + I E++ + ++
Sbjct: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
Query: 3047 ATDADIRSNAEITYTLLGSGAEK----FKLNPDTGELKTSTPLDREEQAVYHLLVRATDG 3102
ATD D N + Y+ L + + F ++P +G ++T+ LDRE QAVY L++ A+D
Sbjct: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDL 2696
Query: 3103 GGRF---CQASIVLTLEDVNDNAPEFSADPYA------ITVFENTEPGTLLTRVQ-ATDA 3152
G + + LED++DN P F P +TV E++ GTL+ V A DA
Sbjct: 2697 GQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDA 2756
Query: 3153 DAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGL---PRR 3209
D G N + Y + + + + G + + + LDRE +A+++ +KA PR
Sbjct: 2757 DEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRG 2816
Query: 3210 LTATGTVIVSVL---------DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIE 3260
+ T ++ + DIND PP F EY A V+ D VG+E++QV A DI
Sbjct: 2817 PSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIG 2876
Query: 3261 ANAEITYSIISGNEHGKFSIDSK-TGAVFIIENLD 3294
N+ + YSI++ + + DS+ G VF + ++D
Sbjct: 2877 NNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
Score = 819 bits (2115), Expect = 0.0
Identities = 793/2906 (27%), Positives = 1283/2906 (44%), Gaps = 278/2906 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
L+RE K +T + ++ + V R KV +QV D ND P F YSV +PENT + T
Sbjct: 93 LDRETKSEFT-VEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
Query: 168 IARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADR 227
I V+ATD D+G G YSF+ + FAI G++ + LDY T+ Y++ + A D+
Sbjct: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDCDQG 284
+ +S++A L + I + P+ + S + + P I+T D D+G
Sbjct: 211 DK----TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
Query: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF---GYNLTL---QA 338
I +IV+G+ T F V + G+ +P G+ LT+ +
Sbjct: 267 RPRGI-GYTIVSGN------TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
Query: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVM---------- 388
D TP + ++ +F Y I+E A + +
Sbjct: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
Query: 389 --------VKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTT 440
V + SH ++ T + K + + E V R F E +
Sbjct: 380 LGLNSMFEVYLVGNNSH-HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SV 437
Query: 441 SDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTY 500
D KV + ++ N N P F+Q Y + ENV +GT+V+++ A D D G G V+Y
Sbjct: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY 497
Query: 501 SIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLN 560
++ + F++D TG + LDYEL+ R +TL I A D G E I +
Sbjct: 498 FFSD-DPDRFSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGG---GEETTGRVRINVL 552
Query: 561 NLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFF--- 615
++NDN P F+K G + + Q+ + A D D + Y I + + +
Sbjct: 553 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDI 612
Query: 616 SLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCE 675
SL GV+S+ R L D L + A D N PL N TV + ++
Sbjct: 613 SLYEGYGVISVSRPL-DYEQISNGLIYLTVMAMDAGN--PPL--NSTVPVTIEV------ 661
Query: 676 ETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSS 735
FD N + P F S + V EN G++
Sbjct: 662 ----------------------------FDE---NDNPPTF-SKPAYFVSVVENIMAGAT 689
Query: 736 VIFMNSTDLDTG---FNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNI 792
V+F+N+TDLD ++Y++ G + F I+ +G + S LDRET +Y L +
Sbjct: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIV 746
Query: 793 TVYDLGI--PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD 850
D G+ QK +++ ++D NDN P + Y++ + E S++ V A D D
Sbjct: 747 RAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPD 806
Query: 851 LGPNGHVTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEH------SLKIEARDQARE 903
LG NG + YSI +S++S TG + LDRE H + + D R
Sbjct: 807 LGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
Query: 904 EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR 963
+ S+ V V+L D+NDN PTF + +V E +P G I + A D D G +G V
Sbjct: 867 PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926
Query: 964 YSL-LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEV 1022
Y + + +F ++ SG V +LD E+ Y L V A D G P SST + + V
Sbjct: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIHV 985
Query: 1023 VDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVF 1082
+DVN+ P F V +V ED P V+ ++ D D + E+ Y I G+ G F
Sbjct: 986 LDVND--ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKF 1043
Query: 1083 KIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPL--SSFIEIYIEVEDVNDNAPQTS 1140
+G V+ T LDRE+T+ Y L + A D G V + +++ V DVNDN P
Sbjct: 1044 SVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFL 1103
Query: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS 1200
+ Y + E+ P+ S++Q++A D D ++ Y+I GN F IH GL+
Sbjct: 1104 QSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGP 1163
Query: 1201 RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP 1260
R LDRE+ H+L V ++ P + RVIV + D ND P F Q+ Y RL RE
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETA 1222
Query: 1261 DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEY 1320
+ + V ATD+D G ++Y I G E GKF I+ TG++ + + +Y
Sbjct: 1223 GIGTS-----VIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYL---DY 1273
Query: 1321 D-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAH 1375
+ ++++ A D P ++I +++ E + F + + ++E+ +A
Sbjct: 1274 ETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---EAVQFSNASYEAAILEN--LAL 1328
Query: 1376 MIGVISVEPPGIPLWFDI-------TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLT 1428
++ V+ I I T + F +D TG I V +D E+ Y LT
Sbjct: 1329 GTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLT 1388
Query: 1429 VEATDGTTTI--LTQVFIKVIDTNDHRPQFS-TSKYEVVIPEDTAPETEILQISAVDQD- 1484
V A DG + +V+I V+D ND+ P+F TS V IPED + + A D D
Sbjct: 1389 VVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDA 1448
Query: 1485 -EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKR 1543
+++++L S + + + + G ++ + LD E + + L V+ D+ P ++
Sbjct: 1449 GSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRK 1508
Query: 1544 NFARIVVNVSDTNDHAPWFTAS-SYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIE 1602
+ V + D ND+ P + Y V E+ G+ V+QV A D+D G N+ + Y I
Sbjct: 1509 KDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
Query: 1603 SGNIGNSFMIDPVLGSIKT-AKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661
GN +F +D + G I T DR Q+ Y L+ D+G+P +S T V + + +
Sbjct: 1569 EGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
Query: 1662 NASPKFTSKEYSVELSETVSIGSFVGMVTAHS-------QSSVVYEIKDGNTGDAFDINP 1714
+ +P F Y V L E + ++T + +V Y I GN + F I+
Sbjct: 1629 DNAPMFQQPHYEVLLDEGPDTLN-TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDR 1687
Query: 1715 HSGTIITQKALDFE-TLPIYTLIIQGTNMA-----GLSTNTTVLVHLQDENDNAPVFMQA 1768
H G I K LD+E + YTLI+ T+ L++ TTVLV++ D NDN P F +
Sbjct: 1688 HMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR- 1746
Query: 1769 EYTGLISESASINSVVLTDRNVPLV--IRAADADKDSNALLVYHIVEPSVHTYFAIDSST 1826
+Y G V + P V A D D N + Y I++ F I
Sbjct: 1747 DYEGPFE--------VTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVE 1798
Query: 1827 GA--IHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
G + + LD E + ++ T+ D G P L + V + V+DIND PV
Sbjct: 1799 GVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTML--VGIRVLDINDNDPVLLNLPM 1856
Query: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQL 1944
++ + V V A+DADS ++L ++IT GN F ++ TG +TV
Sbjct: 1857 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDR 1916
Query: 1945 R--SRYELTVRASDG----RFA--GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAE 1996
Y+LT+ D R A + I + + ++H FT+ Y A V ENS
Sbjct: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
Query: 1997 TLAVITA------IGNPINEPLFYHILNPDR-RFKISRTSGVLST-TGTPFDRE--QQEA 2046
L V+ I + Y +L F I+ ++GV++ +G DRE
Sbjct: 1977 PLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPI 2036
Query: 2047 FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAV 2106
++++ + ++ AH+++ ++ D NDN P F + + G + VTA
Sbjct: 2037 LELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT 2094
Query: 2107 DRDSGRNGEVHYYLKE-HHEHFQIGPLGEISLKKQFELDTLNKE-YLVTVVAKDGGNPAF 2164
D DSG NGE+ Y ++ + F I + + +D +E Y +TVVA D G
Sbjct: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154
Query: 2165 SAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSIT-- 2219
S IV I + +N + P F P + + ES + + + ++ A + K+ Y I
Sbjct: 2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGI 2214
Query: 2220 ----DGDPF-----SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATD--------SLTG 2262
D D F +N NTG + V +P++ E Y++++ D S++
Sbjct: 2215 VAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSV 2274
Query: 2263 AHAEVFVDIIVDDINDNPPVFAQ---QSYAVTLSEASVIGTSVVQVRATDSDSEPNRGIS 2319
+A++ V+++ D+NDN P F Y + E + GT+++ V A D D N ++
Sbjct: 2275 PNAKLTVNVL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVT 2332
Query: 2320 YQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
Y + + DSS G + RT+DYE+ VRA D G P ++++ V ++
Sbjct: 2333 YTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLE 2391
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFV 2439
+ D+NDN P+F+Q Y+ + E P G + V A DADS + ++YS+ G+ F
Sbjct: 2392 IVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFA 2449
Query: 2440 IDSATG-IITLSNLHRHALKPFYSLNL-------SVSDGVFRSSTQVHVTVIGGNLHSPA 2491
I+ TG I LS+L R K Y L V+ +S QV + V+ N P
Sbjct: 2450 INPTTGDIYVLSSLDREK-KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508
Query: 2492 FLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTL 2551
F + ++ + EN P T V+ + TD D G G +TY + + F+++ + T
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTT 2567
Query: 2552 EKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI--LTDDNDNAPQF--RATKYEVNIGS 2607
+ R + + S+ ++A D G + T ++ + D NDN P F ++I
Sbjct: 2568 Q---RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIRE 2624
Query: 2608 SAAKGTSVVKVLASDADEGSNADITYA-IEADSESVKENLEINKLSGVITTKESLIGLEN 2666
++V +V A+D DEG N + Y+ ++ E I+ +SG+I T + L
Sbjct: 2625 EIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQ 2684
Query: 2667 EFFTFFVRAVDNGSP-SKESVVLVYVKI------LPPEMQLPKFSEPFYTFTVSEDVPIG 2719
++ + A D G P E++ + V + P ++ PK S + TV E P G
Sbjct: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRG 2744
Query: 2720 TEIDLIRA-----EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWY 2774
T + + E ++Y + N +++F + + G L + + LD E +
Sbjct: 2745 TLVGNVTGAVDADEGPNAIVYYFIAA----GNEEKNFHL-QPDGCLLVLRDLDREREAIF 2799
Query: 2775 QFSILA---------RCTQDDHEMVASV---DVSIQVKDANDNSPVFESSPYEAFIVENL 2822
F + A R ++VA + +V + ++D ND P F + Y A + +
Sbjct: 2800 SFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDA 2859
Query: 2823 PGGSRVIQIRASDADSGTNGQVMYSL 2848
GS +IQ+ A DAD G N V YS+
Sbjct: 2860 KVGSELIQVLALDADIGNNSLVFYSI 2885
Score = 769 bits (1985), Expect = 0.0
Identities = 791/2831 (27%), Positives = 1265/2831 (44%), Gaps = 289/2831 (10%)
Query: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
F +L Y+ + E+S T V + P + Y IVSG++ ++F A +YI G
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIF-ALDYISG-- 291
Query: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKN-----TNVEARTKVRVQVLDTNDLRPL 148
+ T G N + L VK E N ++ T + V+D ND P
Sbjct: 292 ----VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
Query: 149 FSPTSYSVSLPENTAIRTSIA---RVSATDADIGTNGEF-YYSFKDRTDMFAIHPTSGV- 203
F+ + YSV++ E + ++ +V D ++G N F Y + + F I PTS
Sbjct: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
Query: 204 -----IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVIT 258
I + LDY Y+ ++ A + G AK+ + + N+ P+ +
Sbjct: 408 KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVG------YAKVKITLINENDNRPIFS 461
Query: 259 AVTLSPSELDR-DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKV 317
+ S + +++TV D A G +S D +F + +
Sbjct: 462 QPLYNISLYENVTVGTSVLTVLATDNDA-GTFGEVSYFFSDDPDRFSLDKDTG-----LI 515
Query: 318 KAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEIS 377
I +D++ + LT+ A+D G V++ + F+KD Y +
Sbjct: 516 MLIARLDYELIQ-RFTLTIIARDGGGEETTGRVRINVL---DVNDNVPTFQKDAYVGALR 571
Query: 378 EFAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKF---SLNYNTGLISILEPVKRQQ 430
E P T +V ++A P + + Y S + SL G+IS+ P+ +Q
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
Query: 431 AAHFELEVTTSDRKA-------STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
++ + +T A + V ++V N NPP F++ AY + EN+ G TV+
Sbjct: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
Query: 484 SLSAVDPDEG-ENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASD 542
L+A D D E G + + F I+ +G ++T+ LD E Y L +RA D
Sbjct: 692 FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE-YILIVRAVD 750
Query: 543 WGLPYRREVEVLAT-ITLNNLNDNTPLFEK----INCEGTIPRDLGVGEQITTVSAIDAD 597
G+ + ++ + ITL ++NDN P ++ IN P D +TTV A+D D
Sbjct: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD----SDVTTVVAVDPD 806
Query: 598 --ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
E + Y I+ N+ F+SLN +G + +++D + +
Sbjct: 807 LGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLD--------------RENPDPHEA 850
Query: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
L I V+ + + G + A +F + +N + P
Sbjct: 851 ELMRKIVVSVT---------DCGRPPLKATSSAT------------VFVNLLDLNDNDPT 889
Query: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLK 775
F++ LP +V E P G S+ + + DLD G NG + Y + G F+I+ +G++
Sbjct: 890 FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
Query: 776 ILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDK 835
+ LDRE +Y L + D G P K++ L + V+D ND P F Y V VSED
Sbjct: 949 TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
Query: 836 EVHSEIIQVEATDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSL 893
++ + TD D+G N ++Y I FS+ VV LDRE + L
Sbjct: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML 1068
Query: 894 KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHD 953
+EA D + T V V++ DVNDN P F+ +Y V ED+PEG I+ L+A D
Sbjct: 1069 ILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATD 1128
Query: 954 PDLGQSGQVRYSLLDHGEGN-FDVDKLSGAV-RIVQQLDFEKKQVYNLTVRA--KDKGKP 1009
D G+ G+V Y +L GN F + +G + R + LD E+ + L V A D G
Sbjct: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGP- 1187
Query: 1010 VSLSSTCYVEVEVVDVNENLHPPVFSSF-VEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068
+ S+ V V V D+N+ PVF+ + ++E A +G+ V+ V A D D+ G
Sbjct: 1188 --MRSSVRVIVYVEDINDEA--PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
Query: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128
+ Y I G+ G F+I E TG+I T + LD E+ + Y + V ATDQ F +YI
Sbjct: 1244 VNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKI-TSGNPQGFF 1187
+ + D A Q S Y I+EN +V+++A+ D+ + + TS + F
Sbjct: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALF 1362
Query: 1188 SIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF-L 1246
I TG+IT +DRE+ D + L V V D+G P + +V + +LDENDN P+F
Sbjct: 1363 KIDAITGVITVQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFI---E 1303
+ +PE + P +R A V A D D G N ++ +S+ GN G F I
Sbjct: 1421 TSDSAVSIPE-DCPVGQRVAT------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473
Query: 1304 PKTGVVSSKRFSAAGEYD--ILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPISFE 1359
G V R E D IL + A D G P +K ++ I I+ P +E
Sbjct: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE----- 1528
Query: 1360 ESFFTFTVMESDPVAHMIGVISVEPP----GIP--LWFDITGGNYDSHFDVDKGTGTIIV 1413
S F + V ++ V V+ V GI L + IT GN D F +D+ +G I
Sbjct: 1529 -SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
Query: 1414 AK-PLDAEQKSNYNLTVEATD-GTTTI--LTQVFIKVIDTNDHRPQFSTSKYEVVIPE-- 1467
P D E++S Y+L D GT T+ T V++ ++D ND+ P F YEV++ E
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
Query: 1468 DTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
DT T ++ I A+D DE + Y + + + FR+D G + +++LD+E
Sbjct: 1648 DTL-NTSLITIQALDLDEGPNGTVTYAIVAGN---IVNTFRIDRHMGVITAAKELDYEIS 1703
Query: 1526 H-QHTLTVMVRDQDVPVKRNFAR---IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
H ++TL V DQ + ++VNV+D ND+ P F G V
Sbjct: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
Query: 1582 LQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAK--ELDRSNQAEYDLMVKA 1639
A D+D G N +V YSI G+ F+I PV G ++ K ELDR A Y+L + A
Sbjct: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
Query: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS--- 1696
D+G PP+S V I V ++ P + ++ +SE + SFV V A S
Sbjct: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
Query: 1697 --VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTN-----MAGLSTNT 1749
+ + I GN AF IN +G + + LD E +P Y L I +
Sbjct: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
Query: 1750 TVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY 1809
+L+ L DENDN P+F ++ Y + E++ + LT N P++ A DAD+D A++ Y
Sbjct: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP-LTVLNGPIL--ALDADQDIYAVVTY 2000
Query: 1810 HIVEPSVHTYFAIDSSTGAIHTVLS---LDYEETS--IFHFTVQVHDMGTPRLFAEYAAN 1864
++ F I+SSTG + TV S +D E S I + D+G A+
Sbjct: 2001 QLLGAQ-SGLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAH 2054
Query: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIG 1924
+ + ++D ND P F+ LL G V+ V ATD DS +L+Y I E
Sbjct: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQ 2113
Query: 1925 EKFSMDYKTGALTVQNTT---QLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978
++F + TG + V N T + + Y LTV A+D +G V I + + +S +
Sbjct: 2114 DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPE 2173
Query: 1979 FTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHIL-------------NPDRRFKI 2025
F + + V E++ +A ITAI + +N L YHI+ N + F +
Sbjct: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV 2233
Query: 2026 SRTSGVLSTTGTPFDREQQEAFDVVVEVTEE-----HKPSAVAHVVVKVIVEDQNDNAPV 2080
+ +G + +P +RE ++V + V + + +V + + V V D NDN P
Sbjct: 2234 NINTGSVMVK-SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
Query: 2081 F--VNLPYYAV-VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISL 2137
F + YY + G + V AVD D G NG V Y L + + P G + L
Sbjct: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD------LVPPGYVQL 2346
Query: 2138 K-----KQFELDTLNKEYL----VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF 2186
+ K T++ E + TV A D G+P +AE+ V + ++ N P+F++P
Sbjct: 2347 EDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPS 2406
Query: 2187 YSAEIAESIQVHSPVVHVQANSPEG---LKVFYSITDGDPFSQFTINFNTGVINVIAPLD 2243
Y + E + V + ++ V A + + YS+ DG+ S+F IN TG I V++ LD
Sbjct: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLD 2464
Query: 2244 FEAHPAYKLSIRATDS---LTGAHAEVFVDIIVD--DINDNPPVFAQQSYAVTLSEASVI 2298
E Y L+ A D+ + E V +++ D+ND P F++ ++ ++ E
Sbjct: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
Query: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTI 2358
GTSV+ + ATD D PN ++Y + G ++ FHVD +GL++ R L + + ++
Sbjct: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSL 2579
Query: 2359 FVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYD 2416
V A DGG P L ++ V+V D+NDN P+F + I E P V V A D
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 2417 ADSSDIDKLQYSIL--SGN-DHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD---- 2469
D ++YS L +GN D + F+ID +G+I + + YSL L SD
Sbjct: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
Query: 2470 GVFRSSTQVHVTVIGGNLHSPAFLQN-----EYEV-ELAENAPLHTLVMEVK-TTDGDSG 2522
+ + + V + + + P F++ +Y++ + E++P TLV V D D G
Sbjct: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
Query: 2523 IYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAK----------- 2571
V Y I + F++ G + L LDRE A V+ +
Sbjct: 2760 PNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP 2819
Query: 2572 --DAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNA 2629
D + V V+L D ND P+F +Y + + A G+ +++VLA DAD G+N+
Sbjct: 2820 TLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNS 2879
Query: 2630 DITYAIEA---------DSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2680
+ Y+I A DSE V + + + G++ T + + +F + A D
Sbjct: 2880 LVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAG 2939
Query: 2681 PSKESVVLVYV 2691
+ +++ +Y+
Sbjct: 2940 HNDTAIIGIYI 2950
Score = 639 bits (1649), Expect = 0.0
Identities = 603/2160 (27%), Positives = 977/2160 (45%), Gaps = 165/2160 (7%)
Query: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQ 1630
+ E VGS V Q+ A D D N +++ + F ++P G + + LDR +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 1631 AEYDLMVKATDKGSPPMSEIT-SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
+E+ + +D IT V I V ++ +P F ++ YSV + E +G+ + +V
Sbjct: 99 SEFTVEFSVSDH----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
Query: 1690 TAHSQS-----SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM-- 1742
A SV+Y + + F I+ G + + LD+ET Y L + T+
Sbjct: 155 NATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
Query: 1743 -AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK 1801
LST + + + D D P+F+ Y+ I E + + V +I A D DK
Sbjct: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR-------IITAIDQDK 265
Query: 1802 DSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFH---FTVQVHDMGTPRLF 1858
+ Y IV + ++ FA+D +G + LD E H TV+ ++ R
Sbjct: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 1859 AEYAANVTVH--VIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDADSSAFSQLI 1915
++ T + VIDIND P F Y ++ G + + + D D + +
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
Query: 1916 YSI-TEGNIGEKFSMDYKTGALTVQNTTQLRSR------YELTVRASDGRFA-------- 1960
+ + GN F + +VQ +R R YE R FA
Sbjct: 386 FEVYLVGNNSHHFIIS----PTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
Query: 1961 GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP---INEPLFYHIL 2017
G VKI + ++ F+Q +Y+ + EN T ++ + A N E ++
Sbjct: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
Query: 2018 NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDN 2077
+PDR F + + +G++ D E + F + + + V + V+ D NDN
Sbjct: 502 DPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDN 557
Query: 2078 APVFVNLPYYAVVKV-DTEVGHVIRYVTAVDRDSGRNGEVHYYL---KEHHEHFQIG--- 2130
P F Y ++ + V ++R + A D DS N ++ Y + +F I
Sbjct: 558 VPTFQKDAYVGALRENEPSVTQLVR-LRATDEDSPPNNQITYSIVSASAFGSYFDISLYE 616
Query: 2131 PLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFY 2187
G IS+ + + + ++ + +TV+A D GNP ++ V V I V N P F KP Y
Sbjct: 617 GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAY 676
Query: 2188 SAEIAESIQVHSPVVHVQANSPEGLK------VFYSITDGDPFSQFTINFNTGVINVIAP 2241
+ E+I + V+ + A + + + YS+ +QF IN +G I +
Sbjct: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS---TQFRINARSGEITTTSL 733
Query: 2242 LDFEAHPAYKLSIRATDSLTGAHAEV---FVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298
LD E Y L +RA D G + + V+I + DINDN P + Y + L E +
Sbjct: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
Query: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT-LDYEQSRQHT 2357
+ V V A D D N + Y + + + ++S+TG I LD E H
Sbjct: 794 DSDVTTVVAVDPDLGENGTLVYSI----QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHE 849
Query: 2358 ------IFVRAVDGGMPTL--SSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFV 2409
I V D G P L +S V V++ DLNDN P F+ + A + E P G +
Sbjct: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
Query: 2410 TCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVS 2468
V A D D + Y + G F+I+S++G++ T + L R + Y L + S
Sbjct: 910 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE-YQLRVVAS 968
Query: 2469 DG---VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYG 2525
D S++ + + V+ N +P F Y V ++E+ P V+ + TD D G+
Sbjct: 969 DAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
Query: 2526 HVTYHIVNDFAKDRFYINERGQIF-TLEKLDRETPAEKVISVRLMAKDAGGK--VAFCTV 2582
++Y I +F + R + T+ LDRET A ++ + + GK TV
Sbjct: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATV 1088
Query: 2583 NVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
V + D NDN P F + YE ++ +G S++++ A+DADEG + Y I +
Sbjct: 1089 FVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG- 1147
Query: 2643 KENLEINKLSGVITTKESLIGLE-NEFFTFFVRAVDNG-SPSKESV-VLVYVKILPPEMQ 2699
N I+ +G++ + E N V A ++ P + SV V+VYV+ + E
Sbjct: 1148 -NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEA- 1205
Query: 2700 LPKFSEPFYT-FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVI 2753
P F++ Y+ + E IGT + +++A G V Y ++ G + F I
Sbjct: 1206 -PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG------AEGKFEI 1258
Query: 2754 DRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSP 2813
D +G + LD+ET Y ++ A V I + + D + F ++
Sbjct: 1259 DESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ-GFCSVYITLLNELDEAVQFSNAS 1317
Query: 2814 YEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLK 2873
YEA I+ENL G+ +++++A D+ Q+ Y + S + F I+ TG IT
Sbjct: 1318 YEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQG 1375
Query: 2874 ELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKG-TVSEDDP 2932
+D EK D Y + VVA D G K+ ST V +TV D ND+ PRF ++ ED P
Sbjct: 1376 LVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
Query: 2933 QGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLDREKRDN 2991
G +A + D D+ N QV + + G+ G F + T + +V+V +PLDRE+ D+
Sbjct: 1434 VGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDH 1492
Query: 2992 YLLTITATD-GTFSSKA--IVEVKVLDANDNSPVCEKTL-YSDTIPEDVLPGKLIMQISA 3047
Y+L + A+D GT K I++V +LD NDN PV E Y+ ++ E+V G ++Q+ A
Sbjct: 1493 YILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
Query: 3048 TDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTS-TPLDREEQAVYHLLVRATDGGGR 3105
TD DI N+ ++Y + G+ F+++ +GE+ T P DRE Q+ YHL+ D G
Sbjct: 1553 TDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP 1612
Query: 3106 FCQAS--IVLTLEDVNDNAPEFSADPYAITVFENTEP-GTLLTRVQATDADAGLNRKILY 3162
A+ + +T+ D NDNAP F Y + + E + T L +QA D D G N + Y
Sbjct: 1613 TLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY 1672
Query: 3163 SLI-DSADGQFSINELSGIIQLEKPLDRELQ-AVYTLSLKAVDQG--LPRRLTATGTVIV 3218
+++ + F I+ G+I K LD E+ YTL + A DQ L RLT+T TV+V
Sbjct: 1673 AIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLV 1732
Query: 3219 SVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKF 3278
+V DINDN P F G + G V A RD N ++ YSI+ G+ G+F
Sbjct: 1733 NVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEF 1792
Query: 3279 SIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
I G + + ++ LD E+ Y LT+ A D G P LS V + V DINDN PV
Sbjct: 1793 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852
Query: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK 3396
ISE++ + V V+A DAD N+ + ++I GN+ +F I+ G V V +
Sbjct: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNR 1912
Query: 3397 LLDRETISGYTLTVQASDNGSPPRV---NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENK 3453
LDRE I Y LT+ DN PR+ + + I +SD NDN P+F++ Y + EN
Sbjct: 1913 PLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
Query: 3454 PVG--FSVLQLVVTDEDSSHNGPPFFFTIVT----GNDEKAFEVNPQ-GVLLTSSA--IK 3504
P G +VL + D+ + + +VT G F++N GV+ S I
Sbjct: 1973 PAGTPLTVLNGPILALDADQD----IYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIID 2028
Query: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
R+ +L++ + L+S ++ I +++++ P P + + G +
Sbjct: 2029 REAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV 2088
Query: 3565 GKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKL-IAHKKLDIGQ---YLLNVSVTD 3618
++ ATD+D + L Y ++ + F + G + + + +D + Y L V TD
Sbjct: 2089 LQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148
Score = 473 bits (1218), Expect = e-132
Identities = 383/1288 (29%), Positives = 605/1288 (46%), Gaps = 86/1288 (6%)
Query: 2388 PLFEQQIYEAR--ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG 2445
P F ++ ISE P G VT + A D D+ D L + + + F ++ TG
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTG 85
Query: 2446 IITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
++ L K +++ SVSD + +V++ V N ++P F Y V + EN
Sbjct: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
Query: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVND---FAKDRFYINERGQIFTLEKLDRETPAEK 2562
P+ T + V TD D G G V Y FA D + RG + + +LD ET
Sbjct: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID----SARGIVTVIRELDYETTQAY 201
Query: 2563 VISVRLMAKDAGGKVA-FCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
++V +D ++ + +I+TD D P F Y NI + GT+V + A
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
Query: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF-FVRAV---- 2676
D D+G I Y I S + ++ +SGV+T L+ EN ++ F+ V
Sbjct: 262 DQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLN-GLLDRENPLYSHGFILTVKGTE 318
Query: 2677 --DNGSPSKESVVLVY-VKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI-----RAE 2728
D+ +PS +V + + ++ P+F+ Y+ ++E +G + L + E
Sbjct: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
Query: 2729 HSGT----VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
+ G +Y LV N+ + V + R+++ LD+ET Y F + A +
Sbjct: 379 NLGLNSMFEVY-LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
Query: 2785 DDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQV 2844
DH V V I + + NDN P+F Y + EN+ G+ V+ + A+D D+GT G+V
Sbjct: 438 PDH--VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
Query: 2845 MYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIV 2904
Y + F+++ +TG I + LD+E + + ++A D G + +T V
Sbjct: 496 SYFFSDDP-----DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ETTGRV 547
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+ V DVND+ P F + Y G + E++P + L TD DS N Q+TY I
Sbjct: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP-NNQITYSIVSASAF 606
Query: 2965 GQ-FAVETIQNEWKVYVKKPLDREKRDNYL--LTITATDG---TFSSKAIVEVKVLDAND 3018
G F + + + V +PLD E+ N L LT+ A D +S V ++V D ND
Sbjct: 607 GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEND 666
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIR---SNAEITYTLLGSGAEKFKLNPD 3075
N P K Y ++ E+++ G ++ ++ATD D I Y+L GS +F++N
Sbjct: 667 NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS--TQFRINAR 724
Query: 3076 TGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ----ASIVLTLEDVNDNAPEFSADPYA 3131
+GE+ T++ LDRE ++ Y L+VRA DGG Q A++ +TL D+NDN P + PY
Sbjct: 725 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
Query: 3132 ITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQL-------E 3184
I + E T P + +T V A D D G N ++YS I + +S+N +G I+ E
Sbjct: 785 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRE 843
Query: 3185 KPLDRELQAVYTLSLKAVDQGLPR-RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243
P E + + + + D G P + T++ TV V++LD+NDN P F+ + A V E I
Sbjct: 844 NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
Query: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303
G + QV A D N ++Y + G F I+S +G V LD E EY L
Sbjct: 904 PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
Query: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDAD 3363
V A+D GTP+ S +T+ ++V D+ND TP F Y +SED E V+ + D D
Sbjct: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
Query: 3364 GPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNG--SPPRV 3421
N+ + Y I GN F++ V+ LDRET + Y L ++A DNG
Sbjct: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHT 1083
Query: 3422 NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
T TV + V DVNDN P+F + +Y + E+ P G S+LQL TD D G ++ I+
Sbjct: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFG-RVWYRIL 1142
Query: 3482 TGNDEKAFEVNPQGVLLTSS--AIKRKEKDHYLLQVKVADNG-KPQLSSLTYIDIRVIEE 3538
GN F ++ LL + R+ ++L V+ ++ P SS+ I V E
Sbjct: 1143 HGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI---VYVE 1199
Query: 3539 SIYPPAILPLEIFITSSGEEYSGGV---IGKIHATDQDVYD--TLTYSLDPQMDNLFSVS 3593
I A + + + G + G+ + + ATD+D D + Y + + F +
Sbjct: 1200 DINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEID 1259
Query: 3594 STGGKLIAHKKLDI---GQYLLNVSVTD 3618
+ G +I LD Y++NVS TD
Sbjct: 1260 ESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 388 bits (997), Expect = e-107
Identities = 455/1705 (26%), Positives = 745/1705 (43%), Gaps = 214/1705 (12%)
Query: 32 LQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKI---VSGDSENLFKAEEY 88
+QF++ Y + EN A T + V++ Y ++ Y+ S ++ LFK +
Sbjct: 1311 VQFSNASYEAAILENLALGTEI---VRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA- 1366
Query: 89 ILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPL 148
I G I +G +++RE D YTL V A + V++ KV + VLD ND P
Sbjct: 1367 ITGV-----ITVQG----LVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPR 1417
Query: 149 FSPTSYS-VSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-----DMFAIHPTSG 202
F TS S VS+PE+ + +A V A D D G+NG+ +S ++ + + G
Sbjct: 1418 FDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIG 1477
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--- 259
+ + LD E Y ++++A+DRG I L V I N+ PVI +
Sbjct: 1478 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-----LQVTILDINDNPPVIESPFG 1532
Query: 260 VTLSPSE-LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318
+S +E + A V D D G N + S I G+ FR R S E +
Sbjct: 1533 YNVSVNENVGGGTAVVQVRATDRDIGIN-SVLSYYITEGNKDMAFRMDRI---SGEIATR 1588
Query: 319 AIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISE 378
D + F Y+L +D+GT P S+ ++VT F++ Y + E
Sbjct: 1589 P-APPDRERQSF-YHLVATVEDEGT-PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDE 1645
Query: 379 FAPP-NTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ-QAA 432
NT ++ ++A+ + Y + F ++ + G+I+ + + +
Sbjct: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
Query: 433 HFELEVTTSDR--------KASTKVLVKVLGANSNPPEFTQTAYKAAFD--ENVPIGTTV 482
+ L VT +D+ ++T VLV V N N P F + Y+ F+ E P G V
Sbjct: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRV 1763
Query: 483 MSLSAVDPDEGENGYVTYSIANLNHV-PFAIDHFTGAVSTSEN--LDYELMPRVYTLRIR 539
+ A D D G NG V YSI + + + F I G + ++ LD E + Y L I
Sbjct: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTIC 1822
Query: 540 ASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE- 598
A D G+P +L I + ++NDN P+ + TI + V + V A DAD
Sbjct: 1823 ARDRGMPPLSST-MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
Query: 599 -LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657
+ + I AGN F +N +G++++ R L ++ + L I+ D
Sbjct: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLD---RERIPEYKLTISVKDNP------ 1932
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
E +A+ + LL IF + N H +
Sbjct: 1933 -----------------ENPRIARRDYDLLL-------------IFLSDENDN-HPLFTK 1961
Query: 718 STLPTGIQVKENQPVGSSVIFMN----STDLDTGFNGKLVYAVSGGNEDSCFMIDMETGM 773
ST +V EN P G+ + +N + D D + Y + G + F I+ TG+
Sbjct: 1962 STYQA--EVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGV 2018
Query: 774 LKILSP--LDRETTDKYTLNITVY--DLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFV 829
+ + S +DRE L + + D+G+ A L + ++D NDN P F + V
Sbjct: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLTV 2076
Query: 830 EVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGVVNIAR-PLDREL 887
+ E+ ++QV ATD+D G NG + Y I D F I VTGV+ + +DRE
Sbjct: 2077 HLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREE 2136
Query: 888 QHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIM 947
Q + L + A D R L T +V + ++D+ND+ P F+ P V V E GTVI
Sbjct: 2137 QESYRLTVVATD--RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIA 2194
Query: 948 WLEAHDPDLGQSGQVRY----------SLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVY 997
+ A D DL + L+ + E F V+ +G+V + ++ E Y
Sbjct: 2195 NITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATY 2254
Query: 998 NLTVRAKDKGKPVSLSS----TCYVEVEVVDVNEN---LHPPVFSSFVEKGTVKEDAPVG 1050
+T+ D + S + V V+DVN+N P + ++E+ + E A G
Sbjct: 2255 EVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMER--ILEGATPG 2312
Query: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEET-GVIETSDRLDRESTSHYWLTV 1109
+ ++ V+A D D +G + Y++ D G ++ + + G + + +D E TV
Sbjct: 2313 TTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTV 2372
Query: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
A+D G P ++ I +Y+E+ D+NDN P +P Y + E+ P ++ + A D DS
Sbjct: 2373 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2432
Query: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN----GSPPK 1225
+ + Y + G+ + F+I+P TG I S LDRE++D +IL DN S +
Sbjct: 2433 NFALIEYSL--GDGESKFAINPTTGDIYVLS-SLDREKKDHYILTALAKDNPGDVASNRR 2489
Query: 1226 STIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA 1285
+V++++LD ND +PQF + + + E E + ++ATD+DEGPN
Sbjct: 2490 ENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS-------VITMMATDQDEGPNG 2542
Query: 1286 EISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE- 1344
E++YS+E G F ++ +G+V+++R + E L++ A D G P TT L +E
Sbjct: 2543 ELTYSLE-GPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEV 2601
Query: 1345 ---------WISKPKPSLEPISFEESFFT--FTVMESDPVAHMIGVISVEPPGIPLWFDI 1393
++ P ++ I E + + V +D + G + F
Sbjct: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYS-------FLK 2654
Query: 1394 TGGNYD-SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD------GTTTILTQVFIKV 1446
T GN D F +D +G I A+ LD E ++ Y+L + A+D T QV ++
Sbjct: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
Query: 1447 IDTNDH---RPQFSTSKYEVV-IPEDTAPETEILQIS-AVDQDE-KNKLIYTLQSSRDPL 1500
ID N+ RP + +Y+++ +PE + T + ++ AVD DE N ++Y ++ +
Sbjct: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN-- 2772
Query: 1501 SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQ-------------DVPVKRNFAR 1547
K F L P G L LD E + V D+
Sbjct: 2773 EEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQE 2831
Query: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI------ 1601
+ V + D ND P FT + Y V A VGS ++QV ALD D G N+ V YSI
Sbjct: 2832 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYF 2891
Query: 1602 -----ESGNIGNSFMIDPVLGSIKT 1621
+S ++G F + + G ++T
Sbjct: 2892 RALANDSEDVGQVFTMGSMDGILRT 2916
Score = 297 bits (760), Expect = 2e-79
Identities = 318/1181 (26%), Positives = 523/1181 (44%), Gaps = 164/1181 (13%)
Query: 36 HLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCF 95
+L N+T+ ENS ++V H + A + + I +G+ E F F
Sbjct: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAF-----------F 1900
Query: 96 LRIRTKGGNTAI---LNREVKDHY--TLIVKALEKNTNVEARTK--VRVQVLDTNDLRPL 148
+ T G + L+RE Y T+ VK +N + R + + + D ND PL
Sbjct: 1901 INATT--GIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPL 1958
Query: 149 FSPTSYSVSLPENTAIRTSIARVS----ATDADIGTNGEFYYSFKD-RTDMFAIHPTSGV 203
F+ ++Y + EN+ T + ++ A DAD Y ++ +F I+ ++GV
Sbjct: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGV 2018
Query: 204 IVLTGRL----DYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA 259
+ + + + + E+ +LA D G+ ++S A L + I N+ P +
Sbjct: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGL-------LNSTAHLLITILDDNDNRPTFSP 2071
Query: 260 VTLSPSELDR-DPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYK 316
TL+ L+ P +++ VT D D G NG++ I AG Q + G
Sbjct: 2072 ATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAG--AQDRFLIHLVTG----- 2123
Query: 317 VKAIGGIDWD-SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAE 375
V +G D Y LT+ A D+GT P S ++ + +F +
Sbjct: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVP-LSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
Query: 376 ISEFAPPNTPVVMVKAIP-------AYSHLRYVFKSTPGKA------KFSLNYNTGLISI 422
+ E A P T + + AI Y + V K + F++N NTG + +
Sbjct: 2183 VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
Query: 423 LEPVKRQQAAHFELEVTTSDRKA----------STKVLVKVLGANSNPPEFTQ---TAYK 469
P+ R+ A +E+ ++ D + + K+ V VL N N P+F T Y
Sbjct: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAI--DHFTGAVSTSENLDY 527
E GTT+++++AVDPD+G NG VTY++ +L + D G V + +DY
Sbjct: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
Query: 528 ELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQ 587
E + + +RASD G P R E+ + + ++NDN P+F++ + + + D+ VG
Sbjct: 2363 EEVHWL-NFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTI 2420
Query: 588 ITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA 647
I TV+A DAD + G+ F++NP +G + + SL K + L A
Sbjct: 2421 ILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDR---EKKDHYILTALA 2477
Query: 648 TDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSH 707
D +N+ N +V D
Sbjct: 2478 KDNPGDVA----------------------------------SNRRENSVQVVIQVLD-- 2501
Query: 708 SVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI 767
VN PQF S V EN+P G+SVI M +TD D G NG+L Y++ G ++ F +
Sbjct: 2502 -VNDCRPQF-SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHV 2558
Query: 768 DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ--E 825
DM++G++ PL ++ +K++L + D G P +L V V+D NDN P F++
Sbjct: 2559 DMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
Query: 826 SYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT-----DTDTFSIDSVTGVVNIA 880
+ + E+ + S + +V ATDKD G NG V YS + D + F ID ++G++ A
Sbjct: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
Query: 881 RPLDRELQHEHSLKIEARDQAREEPQLFSTVV-VKVSLEDVNDNPPTFI-----PPNYRV 934
+ LDRE Q +SL + A D + P + T+ ++V+LED++DN P F+ P Y++
Sbjct: 2677 QRLDRESQAVYSLILVASDLGQPVP--YETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
Query: 935 -KVREDLPEGTVIMWLE-AHDPDLGQSGQVRYSLL-DHGEGNFDVDKLSGAVRIVQQLDF 991
V E P GT++ + A D D G + V Y + + E NF + G + +++ LD
Sbjct: 2735 LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDR 2793
Query: 992 EKKQVYNLTVRAKD-------KGKPVSLSSTCYV---EVEVVDVNENLHPPVFSSFVEKG 1041
E++ +++ V+A +G +L + EV VV + N PP F+
Sbjct: 2794 EREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTA 2853
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI----------RDGSGVG-VFKIGEETGV 1090
V DA VGS ++ V A D D + + YSI D VG VF +G G+
Sbjct: 2854 GVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGI 2913
Query: 1091 IETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVED 1131
+ T D S ++ + + A D ++ I IYI +D
Sbjct: 2914 LRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2954
Score = 49.3 bits (116), Expect = 9e-05
Identities = 49/182 (26%), Positives = 77/182 (42%), Gaps = 25/182 (13%)
Query: 20 DSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDS 79
D D ++ L P + + +TV E+S T VG+ P V Y I +G+
Sbjct: 2714 DIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNE 2773
Query: 80 ENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEAR------- 132
E F ++ D C L +R L+RE + ++ IVKA + R
Sbjct: 2774 EKNF----HLQPDGCLLVLRD-------LDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
Query: 133 -------TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFY 185
+VRV + D ND P F+ Y+ + + + + + +V A DADIG N +
Sbjct: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
Query: 186 YS 187
YS
Sbjct: 2883 YS 2884
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 719 bits (1856), Expect = 0.0
Identities = 687/2508 (27%), Positives = 1122/2508 (44%), Gaps = 239/2508 (9%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEI----------MENSPKDVSVVQIEAFDPDSSSNDK 1173
E+Y+++ + + Q PE E + K V ++ A D DS
Sbjct: 32 EVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGF 91
Query: 1174 LMYKITSG-----NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTI 1228
+ Y + G PQ F I P G I S+ +DRE+ + +G + T
Sbjct: 92 IEYSLYDGFLSYEAPQAF-RIDPHDGQICV-SQDIDRERDPATYDLLVEAKDGDEQRMTH 149
Query: 1229 ARVI-----------VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIAT 1277
++ V + D NDN P F Y + + +P E + +V+AT
Sbjct: 150 LALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE-------IINVLAT 202
Query: 1278 DKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSI------KAVDNG 1331
D+D G ++Y + GN F I+ TG+ S E +ILS K V N
Sbjct: 203 DQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSP-------EVEILSAVNFSADKEVMNS 255
Query: 1332 RPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWF 1391
R H + + + + + E FE S F + H + V
Sbjct: 256 LEMFLPLLR-HFKKVERDEEAAEK-KFEASRGWFMRFKGRRHLHYLKVQDEAASA----D 309
Query: 1392 DITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVID 1448
Y ++ G G I + PL + + +L V A DG T I V I +
Sbjct: 310 GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 369
Query: 1449 TNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLD 1508
T +F KY ++ ED ++ I + A + ++ I+ SS D KF +
Sbjct: 370 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG--KFSIH 427
Query: 1509 PATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK 1568
P G++ T + LDHE LTV + P + + + V D ND+ P F +S +
Sbjct: 428 PRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDE 486
Query: 1569 GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRS 1628
R+ ++ G+ + A D+D G+N + YSI S G F ID LG + L
Sbjct: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 545
Query: 1629 NQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE--YSVELSETVSIGSFV 1686
Q E L ++A D+G P + + + + + ++ SP +T + Y VE+SE++S + +
Sbjct: 546 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREH-SPSWTFEHLVYQVEVSESLSPMTQM 604
Query: 1687 GMVTAH------SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTL-IIQG 1739
AH + S + Y ++ F I P++G I ++ D+E+ Y +
Sbjct: 605 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664
Query: 1740 TNMAGLSTN--TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAA 1797
G N TTV+V + DENDN+P F+ + ES V+ I A
Sbjct: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK-------ITAI 717
Query: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTV------------------------- 1832
D D N L+Y ++ S +F ++ +TG T+
Sbjct: 718 DMDSGKNGQLLYFLL--SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQ 775
Query: 1833 -------------------LSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDIN 1873
++LD E TV V D G+P A A V V V DIN
Sbjct: 776 AFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA--VYVSVTDIN 833
Query: 1874 DCPPVFAKPLYEASLLLPTYKG----VKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929
D P F + L L + +G + V TV A D D +++ YS++ + + F +
Sbjct: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
Query: 1930 DYKTGALTVQNTTQL----RSRYELTVRASD---GRFAGLTSVKINVKESKESHLKFTQD 1982
D G ++ TT L R Y ++V A+D G V I V + +Q+
Sbjct: 894 DANNG--EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQN 951
Query: 1983 VYSAVVKENSTEAETLAVITA---IGNPINEPLFYHILNPDR--RFKISRTSGVLSTTGT 2037
+ ++ EN + +++I + + N L + I+ D+ F+I ++G L +
Sbjct: 952 IRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLS-K 1010
Query: 2038 PFDREQQEAFDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDNAPVFVNLPYYAVVKVDTEV 2096
D E + V T+ K +++ V + + VEDQND++P F + V+ + +
Sbjct: 1011 ELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPI 1070
Query: 2097 GHVIRYVTAVDRD-SGRNGEVHYYLKEHHE-------HFQIGPLGEISLKKQFELDTLNK 2148
G ++ A D D S N + YY++ H+ H G L +S + + T+
Sbjct: 1071 GTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTV-- 1128
Query: 2149 EYLVTVVAKDGG-----NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVH 2203
++TV A D S + I +N P F F +A + E + V S V H
Sbjct: 1129 --ILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHH 1185
Query: 2204 VQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSL 2260
+ A+ P+ KV YSI G+ F ++ ++G++ PLD+E + L++ A D
Sbjct: 1186 ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
Query: 2261 TGA-HAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGIS 2319
T A + + + V D+ND PVF Q Y ++ E G V +V A D DS N +
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305
Query: 2320 YQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
+++ S + F ++S TG + LD E T+ V DGG P+LSS +
Sbjct: 1306 FEIM--PGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFV 2439
V D ND+ P F Y+ + E+ V V A D D+ + ++Y I+ GN + F
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFT 1422
Query: 2440 IDSATG-IITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVH--VTVIGGNLHSPAFLQNE 2496
I+ +G + T L R + F + L G S+ +H V V+ N HSP+F
Sbjct: 1423 INEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLY 1482
Query: 2497 YEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLD 2555
Y+ + E+A + T+V+ + D D G+ G Y + D A F I+ G + T LD
Sbjct: 1483 YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLD 1541
Query: 2556 RETPAEKVISVRLMAKDA---GGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKG 2612
RE ++ S +A+D G + + V +TD NDN P ++V + +
Sbjct: 1542 REARSQHTFSA--VARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 2613 TSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFF 2672
+ V V A D D G N + ++ A+++S+ I+K +G I +++ +E+F +
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFSF-AETQSM---FSIDKYTGEIQFQQN---PSSEYFPIW 1652
Query: 2673 --VRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHS 2730
++ D G P++ + L+ + + ++++ FS Y V+E+ GT I ++A
Sbjct: 1653 LQLKVTDQGIPARTTTGLLVIHMEGEDVKI-SFSHHLYKGLVTENCEAGTSIVTVKAFAP 1711
Query: 2731 GTVLYSLVKGNTPESNRDESFVIDRQSGRL--KLEKSLDHETTKWYQFSILARCTQDDHE 2788
++ S+ K + N D + +SG+L K K LD E Q +LA H
Sbjct: 1712 DSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE--SSGHR 1768
Query: 2789 MVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL 2848
V V IQ D NDNSP FE S Y+A + E+ + VIQ+ A+D DSG NG + YS+
Sbjct: 1769 AYCKVAVLIQ--DENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSI 1826
Query: 2849 DQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908
S E+F I+ +G ITT LD+E +Y + V A+D G +LS+T ++ V V
Sbjct: 1827 ---LSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQV 1882
Query: 2909 TDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
TD+ND+ P F ++ED G ++ +S D D + + F +P +FA
Sbjct: 1883 TDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLN--SAFIFSFAKESNPGTKFA 1939
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEKTLY 3028
++ QN V + K LD E+ Y L I +D ++ + V+VLD NDN PV + Y
Sbjct: 1940 ID--QNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFY 1997
Query: 3029 SDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTP-LDR 3087
T+PE + G ++ +SAT D+ SN I+Y +L S E F ++P G + T +P L
Sbjct: 1998 QVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKE-FSIDPKNGTIFTISPVLLL 2054
Query: 3088 EEQAVYHLLVRATDGGGRFCQA--SIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLT 3145
+ + LV A+DGG +A + + +ED+N+ APEF+ Y +++ E+ G+ L
Sbjct: 2055 DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLV 2114
Query: 3146 RVQATDAD-AGLNRKILYSLID-SADGQFSIN----------ELSGIIQLEKPLDRELQA 3193
D D N + YS+I ++ F + + G + L LDRE A
Sbjct: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
Query: 3194 VYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVY 3253
+ L + A D G P L++T + + VLD+NDNPP F Y V E +G+ + V
Sbjct: 2175 SHELVILASDSGCP-PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS 2233
Query: 3254 AASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP 3313
A RD ++AEI Y+IISGNE G F ++ TG +++I+ LDYE ++ LTV+A+D
Sbjct: 2234 ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK 2293
Query: 3314 SLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYS 3373
S A V V+V D ND+ P F +++ ++ E+ + ++ ++ A D D + YS
Sbjct: 2294 HFS-FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYS 2352
Query: 3374 IIDG---NQGSS-----FTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTT 3425
I+ G S F IDP+ G++ ++LD E + Y LTVQA D G +
Sbjct: 2353 IVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD--ATASLV 2410
Query: 3426 VNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNG 3473
V +D+ +++ P+F++ Y + E + ++ +D D+ +G
Sbjct: 2411 VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDG 2458
Score = 638 bits (1645), Expect = 0.0
Identities = 599/2211 (27%), Positives = 970/2211 (43%), Gaps = 166/2211 (7%)
Query: 333 NLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
+L + A+D G + V IH+ Q P +FE+ Y + E P ++P+ VKA
Sbjct: 344 SLMVSAQDGGGLTAVINADVTIHIF--QTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA 401
Query: 392 ---IPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKA--- 445
+ + + Y S KFS++ G I +P+ + L V A
Sbjct: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 461
Query: 446 -STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN 504
ST+V + V+ N N P F +T+ + + P GT + A D D G NG + YSIA+
Sbjct: 462 SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS 521
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLND 564
FAID G + + +L R TL +RA D G+ + + VL + +
Sbjct: 522 PQPGVFAIDRALGVLFLNGSLGAG-EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHS 580
Query: 565 NTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL---VQYQIEAGNELDFFSLNPNS 621
+ FE + + + L Q+ A + ++Y +E + F + P +
Sbjct: 581 PSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT 640
Query: 622 GVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLYINI------TVAASHKLVNLQ 673
G + L+R +F DG +N +T + + + + H ++ L+
Sbjct: 641 GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK 700
Query: 674 CEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVG 733
EE+ V + + G++ I DS N + F + ++ N
Sbjct: 701 VEESPVPQGVI------------GKITAIDMDS-GKNGQLLYFLLSDGKFFKMNPNTGPA 747
Query: 734 SSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI-----DMETGMLKILSPLDRETTDKY 788
++ + D F+G +A S +E F++ ++ G L LDRE +
Sbjct: 748 GTIYVITWADGAAAFSG-TDFAFS-SDELQAFVLKSLFCELGEGELINWVALDREHRGHH 805
Query: 789 TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ----ESYFVEVSEDKEVHSEIIQV 844
+ + V D G P + A ++V V D NDN P F Q + V+V E + V+ + V
Sbjct: 806 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 865
Query: 845 EATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
A D D G N VTYS+ ++ +D F ID+ G + L + + + + + A DQ
Sbjct: 866 FAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG- 924
Query: 903 EEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SG 960
P L VV + + ++ + N R + + + T IM L L Q +G
Sbjct: 925 -VPPLQGQAVVNIQVIPLSKG-RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
Query: 961 QVRYSLL-DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVE 1019
++ +S++ D +G+F++D +G + + ++LD+E Y V D K +SLSST ++
Sbjct: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
Query: 1020 VEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR-RDGEIRYSIRD-GS 1077
++V D N+ H P F + +V+E+ P+G+LV +A D+D + I+Y I
Sbjct: 1043 IDVEDQND--HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNP 1100
Query: 1078 GVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLS---SFIEIYIEVEDVND 1134
G F I G + T RLDRES LTV A+DQ V + I + DVND
Sbjct: 1101 GTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVND 1160
Query: 1135 NAPQTSEPVYYP--EIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPK 1192
+ P + +P + E+ V I A DPD N K+ Y I SGN F +
Sbjct: 1161 HNPTF---ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDES 1217
Query: 1193 TGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKI 1252
+GL+TTT LD E + +HIL V D+G+P S+ + V +LD ND P F Q Y+
Sbjct: 1218 SGLLTTTC-PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA 1276
Query: 1253 RLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312
+ E + P E + V A D+D G N+++ + I G F I TG V +
Sbjct: 1277 SVKENQNPG-------EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTT 1329
Query: 1313 RFSAAGEYDILSIKAV--DNGRPQKSSTTRL---------HIEWISKPKPSLEPISFEES 1361
++ +++ + D G P SSTT + H +E + +E
Sbjct: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP 1389
Query: 1362 FFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQ 1421
+TV+ SD A + + I GN D F +++ +G + + LD EQ
Sbjct: 1390 EVVYTVLASDMDAGNNRAVE---------YHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
Query: 1422 KSNYNLTV---EATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQI 1478
SN+ L + + D + + + ++V+D NDH P F T Y+ + ED T +L +
Sbjct: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
Query: 1479 SAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRD 1536
SAVD+DE + Y L + F +DP +G+L TS LD EA QHT + + RD
Sbjct: 1501 SAVDKDEGLNGQTEYFLTDE----ASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARD 1556
Query: 1537 QDVPVKRNFARIV-VNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNA 1595
+ R+ I+ V V+D ND+ P + + + + + V A D D G N
Sbjct: 1557 CSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNG 1616
Query: 1596 EVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYD---LMVKATDKGSPPMSEITS 1652
V++S + F ID G I + ++ +EY L +K TD+G P + T
Sbjct: 1617 TVVFSF--AETQSMFSIDKYTGEI----QFQQNPSSEYFPIWLQLKVTDQGIPART-TTG 1669
Query: 1653 VRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS----QSSVVYEIKDGNTGD 1708
+ + ++ F+ Y ++E G+ + V A + Q S+ Y I GN
Sbjct: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
Query: 1709 AFDINPHSG--TIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFM 1766
+ SG T+ K LDFE LI+ + +G V V +QDENDN+P F
Sbjct: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHRAYCKVAVLIQDENDNSPCFE 1788
Query: 1767 QAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSST 1826
Q+ Y +SES N+ V+ + A D D N L+ Y I+ + F ID+ +
Sbjct: 1789 QSIYQASVSESQLYNAHVIQ-------VFATDLDSGLNGLIEYSILSGNQEEAFQIDALS 1841
Query: 1827 GAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEA 1886
G I T LDYE TS + VQ D G PRL + V V DIND P F P
Sbjct: 1842 GVITTKAILDYELTSSYSLIVQATDKGMPRL--SNTTVIKVQVTDINDNAPAFL-PSEAV 1898
Query: 1887 SLLLPTYKGVKVITVNATDADSSAFSQLIYSIT-EGNIGEKFSMDYKTGALTVQNTTQLR 1945
+ + GV V V+ D D + S I+S E N G KF++D TG + + T
Sbjct: 1899 EITEDSLPGVIVTHVSVHDVDLN--SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE 1956
Query: 1946 --SRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA 2003
+ YEL ++ SD ++ + V + ++ F+QD Y V E+ ++ ++A
Sbjct: 1957 EMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Query: 2004 IGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVA 2063
NE + Y IL+ + F I +G + T + +VE ++ P A
Sbjct: 2017 TDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRA 2076
Query: 2064 HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR----------- 2112
+V++ +ED N+ AP F Y + D VG + + +D D R
Sbjct: 2077 LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIIS 2136
Query: 2113 ---NGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVI 2169
H K H + +G + L + + LV ++A D G P S+ +
Sbjct: 2137 GNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELV-ILASDSGCPPLSSTAV 2195
Query: 2170 VPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSITDGDPF 2224
+ I V+ N P F Y + ES + S + V AN + ++ Y+I G+
Sbjct: 2196 ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK 2255
Query: 2225 SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFA 2284
F + NTGV+ +I PLD+E + L+++A+D+ + V + V D ND+ P F
Sbjct: 2256 GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM 2315
Query: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQM----FGNHSKSHDH--FHVDSS 2338
S++ + E I +++ + A D D+ P ++Y + F H S+DH F +D
Sbjct: 2316 FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL 2375
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
TG I + LDYE ++ + V+A D G T S ++V VD+ +++ P+F Q Y
Sbjct: 2376 TGDIHAKQILDYENGNKYCLTVQAKDKGDATAS--LVVWVDIEGIDEFEPIFTQDQYFFT 2433
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
+ E + V+A DAD+ + YS+ G F ++ G I L
Sbjct: 2434 LPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
Score = 611 bits (1575), Expect = e-174
Identities = 651/2511 (25%), Positives = 1083/2511 (43%), Gaps = 242/2511 (9%)
Query: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDG----NEHGKFFIEPKTGVVSSK----R 1313
+E NA+ V A+D D G I YS+ DG F I+P G + R
Sbjct: 67 QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126
Query: 1314 FSAAGEYDILSIKAVDN------------GRPQKSSTTRLHIEWISKPKPSLEPISFEES 1361
YD+L ++A D G + R+ +E ++ P P ++ S
Sbjct: 127 ERDPATYDLL-VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTS 185
Query: 1362 FFTFTVMESDPVAHMIGVISVEPP-GI--PLWFDITGGNYDSHFDVDKGTGTIIVAKPLD 1418
E+ P +I V++ + GI + +++ GN S F +D TG + + ++
Sbjct: 186 ISD----ETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG--LYSPEVE 239
Query: 1419 AEQKSNYNLTVEATDGTTTILTQV--FIKVI-DTNDHRPQFSTSKYEVVIPEDTAPETEI 1475
N++ E + L + F KV D +F S+ + + +
Sbjct: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYL 299
Query: 1476 -LQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
+Q A D + ++R +L K G +Y + L H + TL++MV
Sbjct: 300 KVQDEAASADGE-------AAARYVANLAKIL---GEGIIYLTLPLSH--LESTTLSLMV 347
Query: 1535 RDQD---VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
QD + N A + +++ T F Y VYE S + V A +
Sbjct: 348 SAQDGGGLTAVIN-ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-L 405
Query: 1592 GKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEIT 1651
+ + Y I SG++G F I P LG+I+T K LD Q L V+A GS P T
Sbjct: 406 NSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSST 464
Query: 1652 SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNT 1706
V I V ++ P F + +S+T G+ + + A + S + Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
Query: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLII----QGTNMAGLSTNTTVLVHLQDENDNA 1762
G F I+ G + +L TL + QG + TV++ + E+ +
Sbjct: 525 G-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKR-EHSPS 582
Query: 1763 PVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT-YFA 1821
F Y +SES S + +L + PL + A A + + +EPSV + F
Sbjct: 583 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA-------ASPLRYSLEPSVDSAMFG 635
Query: 1822 IDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAK 1881
I TG I+ DYE T ++F V + + V V V D ND P F
Sbjct: 636 IRPYTGWIYLRRQFDYESTQTYNFRVFAW-IPEDGFLQNVSTTVIVRVWDENDNSPTF-- 692
Query: 1882 PLYEASLLL----PTYKGVKVITVNATDADSSAFSQLIYSITE-----------GNIGEK 1926
L++ L P +GV + + A D DS QL+Y + G G
Sbjct: 693 -LHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTI 750
Query: 1927 FSMDYKTGALTVQNTTQLRSRYELTVR------------------ASDGRFAGLTSVKIN 1968
+ + + GA T S EL A D G + +
Sbjct: 751 YVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVL 810
Query: 1969 VKESKESHLKFTQDVYSAVVKENSTE--------AETLAVITAIGNPIN----------- 2009
V + T VY +V N + L V G P+N
Sbjct: 811 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDP 870
Query: 2010 -----EPLFYHILNPDR--RFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAV 2062
+ Y + + D FKI +G + TT T + + ++ + V T++ P
Sbjct: 871 DEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTT-TILSYDYRPSYRMSVIATDQGVPPLQ 929
Query: 2063 AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDR-DSGRNGEVHYYL- 2120
VV + V + + + ++ + + ++ + + D NG++H+ +
Sbjct: 930 GQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIV 989
Query: 2121 -KEHHEHFQI-GPLGEISLKKQFELDTLNKEYLVTVVAKDGG-NPAFSAEVIVPITV--M 2175
+ HF+I G++ L K+ + +T + YL V+ D N + S+ V + I V
Sbjct: 990 ADDKDGHFEIDSSTGDLFLSKELDYETTS-HYLFRVITTDHSKNLSLSSTVFLSIDVEDQ 1048
Query: 2176 NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGL----KVFYSITDGDPFSQ-FTIN 2230
N P F+ + E++ + + V A +G ++ Y I +P + F I+
Sbjct: 1049 NDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIH 1108
Query: 2231 FNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH----AEVFVDIIVDDINDNPPVFAQQ 2286
+ G + ++ LD E+ P L++ A+D + I++ D+ND+ P F
Sbjct: 1109 PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF 1168
Query: 2287 SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLL 2345
A + E +G+ V + A D D N ++Y + GN + + F +D S+GL++
Sbjct: 1169 PNA-HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT---FMLDESSGLLTTT 1224
Query: 2346 RTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPH 2405
LDYE QH + V A+D G P LSS +TV V D+ND P+F+Q +YEA + E+
Sbjct: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
Query: 2406 GHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNL 2465
G FVT V+A D DS KLQ+ I+ G + F I+S TG + + + ++ ++L +
Sbjct: 1285 GEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRV 1344
Query: 2466 SVSDGVF---RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSG 2522
V DG F S+T + TV N H+P F+ + Y++E+ EN +V V +D D+G
Sbjct: 1345 LVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAG 1403
Query: 2523 IYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGG--KVAF 2579
V YHI++ + F INE G++ T LDRE + ++ ++ D G + +
Sbjct: 1404 NNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISN--FTLVILCSDLGDPPRSSV 1461
Query: 2580 CTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADS 2639
+ V + D ND++P F Y+ ++ A GT V+ + A D DEG N Y + ++
Sbjct: 1462 IHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEA 1521
Query: 2640 ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVD---NGSPSKESVVLVYVKILPP 2696
I+ +SG + T +L TF A D GS S ++ VYV +
Sbjct: 1522 SGA---FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578
Query: 2697 EMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESF 2751
+ + PF F +S + P ++RA+ +GTV++S + F
Sbjct: 1579 NDPVLE-QNPFDVF-LSPESPTNQTTVIVRADDLDLGPNGTVVFSF-------AETQSMF 1629
Query: 2752 VIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQV--KDANDNSPVF 2809
ID+ +G ++ +++ E F I + D + A + V + D F
Sbjct: 1630 SIDKYTGEIQFQQNPSSE-----YFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISF 1684
Query: 2810 ESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWI 2869
Y+ + EN G+ ++ ++A DS + YS+ V+ ++ ++G +
Sbjct: 1685 SHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVL---SLCSKSGQL 1740
Query: 2870 TTL--KELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTV 2927
T K LD E R+ Q+ V+A G + V V + D ND+ P F IY+ +V
Sbjct: 1741 TVKEPKFLDFEVRNEVQLIVLAESSGHRAYCK----VAVLIQDENDNSPCFEQSIYQASV 1796
Query: 2928 SEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDRE 2987
SE + + TD DS +N + Y I G+ F ++ + + K LD E
Sbjct: 1797 SESQLYNAHVIQVFATDLDS-GLNGLIEYSILSGNQEEAFQIDALSG--VITTKAILDYE 1853
Query: 2988 KRDNYLLTITATD---GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQ 3044
+Y L + ATD S+ +++V+V D NDN+P + + I ED LPG ++
Sbjct: 1854 LTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTH 1912
Query: 3045 ISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG 3104
+S D D+ S ++ + KF ++ +TG + LD EE Y LL++ +D
Sbjct: 1913 VSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SV 1971
Query: 3105 RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL 3164
+ + ++V+ + DVNDN P FS D Y +TV E+ G + + ATD ++ N I Y +
Sbjct: 1972 HYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRI 2029
Query: 3165 IDSADGQFSINELSGIIQLEKP-LDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDI 3223
+ S+ +FSI+ +G I P L + + ++A D G P L A V + + D+
Sbjct: 2030 LSSSK-EFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDM 2087
Query: 3224 NDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD-IEANAEITYSIISGNEHGKFSIDS 3282
N+ P F + Y ++SED LVG+ ++ D N + YSIISGN F +++
Sbjct: 2088 NNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
Query: 3283 K----------TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNT 3332
K G + ++ +LD E+S + L + A+D G P LS A +++ V D+NDN
Sbjct: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
Query: 3333 PVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEV 3392
P FS +Y T + E L + V A+D D S++ I Y+II GN+ F ++ G +
Sbjct: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVL 2267
Query: 3393 KVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQEN 3452
+ K LD E ++ +TLTVQASD + V + V D ND+AP F ++S I+ EN
Sbjct: 2268 YLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPEN 2326
Query: 3453 KPVGFSVLQLVVTDEDSSHNG-------PPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIK 3504
P+ ++ + D D+ G P F T D F ++P G + +
Sbjct: 2327 LPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILD 2386
Query: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
+ + Y L V+ D G S + ++DI I+E + P + F T + +I
Sbjct: 2387 YENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLI 2444
Query: 3565 GKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQYLLN 3613
G++ A+D D + + YSL FSV+ T G + + L + + LN
Sbjct: 2445 GRVEASDADAGIDGVILYSLGTS-SPFFSVNKTNGNIYLIRALPLIKSQLN 2494
Score = 599 bits (1545), Expect = e-170
Identities = 656/2596 (25%), Positives = 1114/2596 (42%), Gaps = 293/2596 (11%)
Query: 160 ENTAIRTSIARVSATDADIGTNGEFYYSFKD------RTDMFAIHPTSGVIVLTGRLD-Y 212
E A V+A+DAD G G YS D F I P G I ++ +D
Sbjct: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
Query: 213 LETKLYEMEILAADRGMK-----LYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSEL 267
+ Y++ + A D + G+S+ A + V +E N+ PV T S
Sbjct: 128 RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 187
Query: 268 DR-DPAYAIVTV--DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGID 324
D P I+ V D D G G +A ++ G++ F T+ S G +V+ + ++
Sbjct: 188 DETQPGTEIINVLATDQDSGIYGTVA-YELIPGNVSSLF-TIDSTTGLYSPEVEILSAVN 245
Query: 325 WDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
+ + DK +S+++ FK K E+D AE +F
Sbjct: 246 FSA------------DKEV---MNSLEMFLPLLRHFK----KVERDEEAAE-KKFEASRG 285
Query: 385 PVVMVKAIPAYSHLRYVFKSTPGKAKFSLNY--------NTGLISILEPVKRQQAAHFEL 436
+ K +L+ ++ + + Y G+I + P+ ++ L
Sbjct: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSL 345
Query: 437 EVTTSDRKASTKVL-----VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP- 490
V+ D T V+ + + P EF + Y E+VP + + ++ A +P
Sbjct: 346 MVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPL 405
Query: 491 DEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
+ E + S +L F+I G + T + LD+E P V L ++A P
Sbjct: 406 NSSEPIFYRISSGDLGG-KFSIHPRLGTIRTRKPLDHETQP-VVVLTVQAQLGSAPACSS 463
Query: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEA 608
EV IT+ ++NDN P F + + E I + G + A D D + L++Y I
Sbjct: 464 TEV--NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-- 519
Query: 609 GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHK 668
+P GV ++ R+L L++N ++ A +
Sbjct: 520 --------ASPQPGVFAIDRAL------------------------GVLFLNGSLGAGEQ 547
Query: 669 ---LVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV-NAHIPQFRSTLPTGI 724
+ L+ E+ GV A LL + + E + H V + + S + +
Sbjct: 548 RELTLTLRAEDQGVHPQAA--LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQML 605
Query: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET 784
Q + + P+G L Y++ + + F I TG + + D E+
Sbjct: 606 QTQAH-PLGPQ-----------RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 653
Query: 785 TDKYTLNITVY--DLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII 842
T Y + + + G Q + ++ V V D NDN P FL + F++V E I
Sbjct: 654 TQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 712
Query: 843 QVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTG------VVNIAR--------------- 881
++ A D D G NG + Y +++D F ++ TG V+ A
Sbjct: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
Query: 882 -----------------------PLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
LDRE + H + + D R P +T+ V VS+
Sbjct: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD--RGSPPRNATMAVYVSVT 830
Query: 919 DVNDNPPTF---IP-PNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL-LDHGEGN 973
D+NDN P F +P VKV E P ++ + A DPD G + +V YS+ + +
Sbjct: 831 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH 890
Query: 974 FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
F +D +G +R L ++ + Y ++V A D+G P L V ++V+ +++ +
Sbjct: 891 FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP-PLQGQAVVNIQVIPLSKG--RAI 947
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDE-DARRDGEIRYSIRDGSGVGVFKIGEETGVIE 1092
S + + E+ ++ + + D +G++ +SI G F+I TG +
Sbjct: 948 MSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLF 1007
Query: 1093 TSDRLDRESTSHYWLTVFATDQGV-VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151
S LD E+TSHY V TD + LSS + + I+VED ND++P + + + EN
Sbjct: 1008 LSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEEN 1067
Query: 1152 SPKDVSVVQIEAFDPDSS-SNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQD 1209
P V A D D S N ++ Y I S NP F IHP G + T SR LDRE
Sbjct: 1068 VPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSR-LDRESIP 1126
Query: 1210 EHILEVTVTD---NGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNA 1266
IL VT +D N + + + ILD ND+ P F I P +E
Sbjct: 1127 TVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF------ISFPNAHV--KEDVT 1178
Query: 1267 RREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD----- 1321
++H+ A D DEG N +++YSI GNE+ F ++ +G++++ + +Y+
Sbjct: 1179 VGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTT---TCPLDYEMKTQH 1235
Query: 1322 ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
IL++ A+D+G P SS+ L + + + E F++ + +V E+ + +
Sbjct: 1236 ILTVLALDDGTPALSSSQTLTVTVLD---VNDEAPVFKQHLYEASVKENQNPGEFVTRVE 1292
Query: 1382 V--EPPGI--PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG--- 1434
G+ L F+I G F+++ TG ++ LD E + + L V DG
Sbjct: 1293 ALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP 1352
Query: 1435 TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKL---IY 1491
+ + T + V D NDH P+F S Y++ + E+ PE + + A D D N +
Sbjct: 1353 SLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYH 1411
Query: 1492 TLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVN 1551
+ + D + F ++ +G L T+ LD E + TL ++ D P + + + V
Sbjct: 1412 IIDGNTD----ECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVR 1467
Query: 1552 VSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFM 1611
V D NDH+P F Y+ V E A VG+VVL ++A+DKD+G N + Y + + +F
Sbjct: 1468 VLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-TDEASGAFT 1526
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATD---KGSPPMSEITSVRIFVTIADNASPKFT 1668
IDP+ G++KT+ LDR ++++ A D +GS S ++++VT ++ P
Sbjct: 1527 IDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVNDNDPVLE 1584
Query: 1669 SKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQK 1723
+ V LS +V A +VV+ + T F I+ ++G I Q+
Sbjct: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYTGEIQFQQ 1642
Query: 1724 ALDFETLPIY-TLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINS 1782
E PI+ L + + +T +++H++ E D F Y GL++E+ +
Sbjct: 1643 NPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGT 1701
Query: 1783 VVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG--AIHTVLSLDYEET 1840
++T + A D+ +DS + Y I + ++ S +G + LD+E
Sbjct: 1702 SIVTVKAF-----APDSIQDS---MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
Query: 1841 SIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT 1900
+ V G R + + V V + D ND P F + +Y+AS+ VI
Sbjct: 1754 NEVQLIVLAESSG-HRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
Query: 1901 VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASD-- 1956
V ATD DS + YSI GN E F +D +G +T + +L S Y L V+A+D
Sbjct: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
Query: 1957 -GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYH 2015
R + T +K+ V + ++ F + + E+S + ++ +N +
Sbjct: 1869 MPRLSNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS 1927
Query: 2016 IL---NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVE 2072
NP +F I + +GV+ T D E+ +++++++++ + A +VV+V+
Sbjct: 1928 FAKESNPGTKFAIDQNTGVVVLVKT-LDFEEMTEYELLIQISDSVHYTEGA-LVVRVL-- 1983
Query: 2073 DQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPL 2132
D NDN PVF Y V VG+ + ++A D +S N + Y + + F I P
Sbjct: 1984 DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPK 2041
Query: 2133 GE--ISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFYS 2188
++ LDT++ + V A DGGNP A +V I + MN P F Y+
Sbjct: 2042 NGTIFTISPVLLLDTISTTQFL-VEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
Query: 2189 AEIAESIQVHSPVVHVQAN----SPEGLKVFYSITDGDPFSQFTINF----------NTG 2234
++E V S +V + E V YSI G+ + F + G
Sbjct: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
Query: 2235 VINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLS 2293
+ ++ LD EA +++L I A+DS + + I V D+NDNPP F+ SY +
Sbjct: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
Query: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
E++ +G+ + V A D D+ + I Y + + K HF+++ +TG++ L++ LDYE+
Sbjct: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKG--HFYLEENTGVLYLIKPLDYEKM 2278
Query: 2354 RQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK 2413
+ T+ V+A D S +V V V D ND+ P F + + E+ P + +
Sbjct: 2279 TKFTLTVQASDAEKKHFSF-AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN 2337
Query: 2414 AYDADSSDIDKLQYSILS--------GNDHKHFVIDSATGIITLSNLHRHALKPFYSLNL 2465
A D D+ +L YSI+S DH F+ID TG I + + Y L +
Sbjct: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV 2397
Query: 2466 SVSD-GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIY 2524
D G +S V V + G + P F Q++Y L E L+ V+ +D D+GI
Sbjct: 2398 QAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGID 2457
Query: 2525 GHVTYHIVNDFAKDRFYINE-RGQIFTLEKL---DRETPAEKVISVRLMAKD--AGGKVA 2578
G + Y + + F +N+ G I+ + L + E + ++++A + K A
Sbjct: 2458 GVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFA 2515
Query: 2579 FCTVNVILTDDNDNAP 2594
CTV V ++ ++ P
Sbjct: 2516 SCTVFVNVSFSSEGTP 2531
Score = 592 bits (1527), Expect = e-168
Identities = 676/2574 (26%), Positives = 1102/2574 (42%), Gaps = 272/2574 (10%)
Query: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGG----NEDSCFMIDMET 771
FRS VKE + + ++D D+G G + Y++ G F ID
Sbjct: 64 FRSQEENAKPVKETE--------VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHD 115
Query: 772 GMLKILSPLDRETTDKYTLNITVYDLGIPQKAA--WRLLHVVVV---------------D 814
G + + +DRE YDL + K R+ H+ +V D
Sbjct: 116 GQICVSQDIDRERDP------ATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLED 169
Query: 815 ANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDS 872
NDN P F +Y +S++ + +EII V ATD+D G G V Y ++ + F+IDS
Sbjct: 170 VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 229
Query: 873 VTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVV--VKVSLEDVNDNPPTFIPP 930
TG+ + E++ ++ A + ++F ++ K D F
Sbjct: 230 TTGLYS------PEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEAS 283
Query: 931 N---YRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQ 987
R K R L +L+ D G+ + N G + +
Sbjct: 284 RGWFMRFKGRRHL------HYLKVQDEAASADGEAAARYV----ANLAKILGEGIIYLTL 333
Query: 988 QLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDA 1047
L + +L V A+D G L++ +V + L P F V ED
Sbjct: 334 PLSHLESTTLSLMVSAQDGG---GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 390
Query: 1048 PVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWL 1107
P S + TV A E I Y I G G F I G I T LD E+ L
Sbjct: 391 PEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVL 449
Query: 1108 TVFATDQGVVPLSSFIEIYIEVEDVNDNAP---QTSEPVYYPEIMENSPKDVSVVQIEAF 1164
TV A G P S E+ I V DVNDN P +TS+ + I + +P ++ A
Sbjct: 450 TVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEI---RISQTTPPGTALYLARAE 505
Query: 1165 DPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP 1224
D DS N + Y I S P G F+I G++ L +Q E L + D G P
Sbjct: 506 DRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNG-SLGAGEQRELTLTLRAEDQGVHP 563
Query: 1225 KSTIARVIVKILDENDNKPQ--FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEG 1282
++ + V+ ++++ ++ P F Y++ + E P + H + +
Sbjct: 564 QAALL-VLTVVIEKREHSPSWTFEHLVYQVEVSESLSP---MTQMLQTQAHPLGPQRAAS 619
Query: 1283 PNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAV-DNGRPQKSST 1338
P + YS+E + F I P TG + +R + + Y+ + ++G Q ST
Sbjct: 620 P---LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 676
Query: 1339 TRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-----EPPGIPLWFDI 1393
T + W +F V ES +IG I+ G L+F +
Sbjct: 677 TVIVRVWDENDNSP----TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
Query: 1394 TGGNY----------------------------DSHFDVDK-------------GTGTII 1412
+ G + D F D+ G G +I
Sbjct: 733 SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELI 792
Query: 1413 VAKPLDAEQKSNYNLTVEATDGTT---TILTQVFIKVIDTNDHRPQFST----SKYEVVI 1465
LD E + ++ +TV TD + V++ V D ND+RP F + V +
Sbjct: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKV 852
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E + + A D DE N T S + S F++D G + T+ L ++
Sbjct: 853 LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSED-SSDHFKIDANNGEIRTTTILSYDYR 911
Query: 1526 HQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVT 1585
+ ++V+ DQ VP + A + + V + + + + E+ ++ +
Sbjct: 912 PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIK 971
Query: 1586 ALDK-DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGS 1644
+ D + N ++ +SI + + F ID G + +KELD + Y V TD S
Sbjct: 972 SSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDH-S 1030
Query: 1645 PPMSEITSVRIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHS------QSS 1696
+S ++V + + + D + SP F + + + E V IG+ V + A S
Sbjct: 1031 KNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSR 1090
Query: 1697 VVYEIKDGNTG-DAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLST-----NTT 1750
+ Y I+ N G + F I+P GT++T LD E++P L + ++ A T + T
Sbjct: 1091 IQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLT 1150
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
+ + D ND+ P F+ + E ++ S+V I A D D+ N + Y
Sbjct: 1151 AQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHH-------ITAHDPDEGRNGKVTYS 1202
Query: 1811 IVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
I+ + + F +D S+G + T LDYE + TV D GTP L + + +TV V+
Sbjct: 1203 ILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSS--SQTLTVTVL 1260
Query: 1871 DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMD 1930
D+ND PVF + LYEAS+ G V V A D DS S+L + I G E F ++
Sbjct: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
Query: 1931 YKTGAL--TVQNTTQLRSRYELTVRASDGRFAGL---TSVKINVKESKESHLKFTQDVYS 1985
TG + T +++ + L V DG F L T++ V++ + +F Y
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD 1380
Query: 1986 AVVKENSTEAETLAVITA----IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPF 2039
V EN E E + + A GN N + YHI+ N D F I+ SG LSTT
Sbjct: 1381 IEVLENQ-EPEVVYTVLASDMDAGN--NRAVEYHIIDGNTDECFTINEMSGELSTT-RAL 1436
Query: 2040 DREQQEAFDVVVEVTEEHKP--SAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVG 2097
DREQ F +V+ ++ P S+V H+ V+V+ D ND++P F L Y + V+ D EVG
Sbjct: 1437 DREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVREDAEVG 1494
Query: 2098 HVIRYVTAVDRDSGRNGEVHYYL-KEHHEHFQIGPLGEISLKKQFELD-TLNKEYLVTVV 2155
V+ ++AVD+D G NG+ Y+L E F I P+ +LK LD ++ + V
Sbjct: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSG-TLKTSNTLDREARSQHTFSAV 1553
Query: 2156 AKD---GGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN----S 2208
A+D G+ + + + V +T +N PV E+ + ++ + V V+A+
Sbjct: 1554 ARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLG 1613
Query: 2209 PEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF 2268
P G VF + + S F+I+ TG I E P + L ++ TD A
Sbjct: 1614 PNGTVVF---SFAETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTG 1669
Query: 2269 VDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK 2328
+ +I + D F+ Y ++E GTS+V V+A DS + + Y +F +
Sbjct: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQD-SMKYSIFSGNED 1728
Query: 2329 SHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPP 2388
S + + LD+E + + V A G V V + D NDN P
Sbjct: 1729 GVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSP 1785
Query: 2389 LFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT 2448
FEQ IY+A +SE + V V A D DS ++YSILSGN + F ID+ +G+IT
Sbjct: 1786 CFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVIT 1845
Query: 2449 LSNLHRHALKPFYSLNLSVSD-GVFR--SSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
+ + L YSL + +D G+ R ++T + V V N ++PAFL +E VE+ E++
Sbjct: 1846 TKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDS 1904
Query: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKD-----RFYINER-GQIFTLEKLDRE-- 2557
+V V D D + + FAK+ +F I++ G + ++ LD E
Sbjct: 1905 LPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEM 1958
Query: 2558 TPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVK 2617
T E +I + G + V + D NDN P F Y+V + S G SV+
Sbjct: 1959 TEYELLIQISDSVHYTEGALV-----VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013
Query: 2618 VLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFT-FFVRAV 2676
+ A+D + SN +I+Y I + S + I+ +G I T ++ L+ T F V A
Sbjct: 2014 LSATDLE--SNENISYRILSSS----KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEAS 2067
Query: 2677 DNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG-TEIDLIRAEHSGT--- 2732
D G+P ++ LV + I P+F+ Y ++SED +G T + +H T
Sbjct: 2068 DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTREN 2127
Query: 2733 --VLYSLVKGNTPESNRDESFVID-----RQSGRLKLEKSLDHETTKWYQFSILARCTQD 2785
V YS++ GN+ + E+ +Q G L L SLD E + ++ ILA
Sbjct: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILA-SDSG 2186
Query: 2786 DHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVM 2845
+ ++ +SIQV D NDN P F S Y + E+ P GS + + A+D D+G++ +++
Sbjct: 2187 CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEII 2246
Query: 2846 YSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVD 2905
Y++ F + TG + +K LD+EK + + V ASD +K S A+V
Sbjct: 2247 YNIISGNEK---GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK--HFSFAVVF 2301
Query: 2906 VTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTY------FIT 2959
V+V D ND P+F + V E+ P I ++ D D+ ++TY F+T
Sbjct: 2302 VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYG-ELTYSIVSPCFLT 2360
Query: 2960 GGDPLGQ--FAVETIQNEWKVYVKKPLDREKRDNYLLTITATD-GTFSSKAIVEVKVLDA 3016
G F ++ + + ++ K+ LD E + Y LT+ A D G ++ +V V +
Sbjct: 2361 HGMSYDHDLFLIDPLTGD--IHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGI 2418
Query: 3017 NDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDT 3076
++ P+ + Y T+PE +LI ++ A+DAD + I Y+ LG+ + F +N
Sbjct: 2419 DEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS-LGTSSPFFSVNKTN 2477
Query: 3077 GEL-------KTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAP 3123
G + + L++E+ ++ + +F ++ + + ++ P
Sbjct: 2478 GNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
Score = 568 bits (1465), Expect = e-161
Identities = 546/2061 (26%), Positives = 890/2061 (43%), Gaps = 237/2061 (11%)
Query: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
F HL Y V V E+ + T + + A +RY + +F Y +
Sbjct: 585 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT--GW 642
Query: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153
+LR + +T N + + E T V V+V D ND P F
Sbjct: 643 IYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 696
Query: 154 YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG----VIVLTG- 208
+ + E+ + I +++A D D G NG+ Y F ++P +G + V+T
Sbjct: 697 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
Query: 209 ---------------------------------------RLDYLETKLYEMEILAADRGM 229
LD +EM +L DR
Sbjct: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR-- 814
Query: 230 KLYGSSGISSMAKLTVHIEQANECAP----VITAVTLSPSELDRDPAYAIVT---VDDCD 282
GS ++ + V + N+ P + L L+ P +VT D D
Sbjct: 815 ---GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD 871
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKG 342
+G N ++ + S+ + D F+ + +++ + +D P Y +++ A D+G
Sbjct: 872 EGNNAEV-TYSVSSEDSSDHFKI-----DANNGEIRTTTILSYDYRP-SYRMSVIATDQG 924
Query: 343 TPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSH----- 397
PP V+++ G +++ I E P + ++K+
Sbjct: 925 VPP-LQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGK 983
Query: 398 LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVL-V 451
L + + F ++ +TG + + + + + +H+ V T+D +ST L +
Sbjct: 984 LHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSI 1043
Query: 452 KVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGE--NGYVTYSIANLN--H 507
V N + P F + +ENVPIGT V +A D D+G N + Y I + N
Sbjct: 1044 DVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGT 1102
Query: 508 VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY--RREVEVLATITLNNLNDN 565
PF I G + T LD E +P V L + ASD + RR + A I + ++ND+
Sbjct: 1103 NPFLIHPSFGTLVTVSRLDRESIPTV-ILTVTASDQAVNVTDRRLRSLTAQIVILDVNDH 1161
Query: 566 TPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLNPNSGV 623
P F + D+ VG + ++A D DE + V Y I +GNE F L+ +SG+
Sbjct: 1162 NPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGL 1220
Query: 624 LSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKML 683
L+ T ++ + H L L ++ G +
Sbjct: 1221 LT-----------------------------TTCPLDYEMKTQHILTVLALDD-GTPALS 1250
Query: 684 AEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTD 743
+ + L L VN P F+ L VKENQ G V + + D
Sbjct: 1251 SSQTLTVTVL--------------DVNDEAPVFKQHLYEA-SVKENQNPGEFVTRVEALD 1295
Query: 744 LDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA 803
D+G N KL + + G F I+ +TG + + LDRE + +TL + V D G P +
Sbjct: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
Query: 804 AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV- 862
+ + V D ND+ PEF+ SY +EV E++E + V A+D D G N V Y I+
Sbjct: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIID 1414
Query: 863 -TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN 921
+ F+I+ ++G ++ R LDRE +L I D +P S + ++V + D N
Sbjct: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG--DPPRSSVIHLQVRVLDAN 1472
Query: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG 981
D+ P+F Y+ VRED GTV++ L A D D G +GQ Y L D G F +D +SG
Sbjct: 1473 DHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSG 1532
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
++ LD E + + + A+D S S+T ++V V DVN+N PV
Sbjct: 1533 TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDN--DPVLEQNPFDV 1590
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ ++P + V A D D +G + +S + +F I + TG I+ +
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ--SMFSIDKYTGEIQ----FQQNP 1644
Query: 1102 TSHY---WLTVFATDQGVV--PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDV 1156
+S Y WL + TDQG+ + + I++E EDV + S +Y + EN
Sbjct: 1645 SSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGT 1701
Query: 1157 SVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRK-LDREQQDEHILEV 1215
S+V ++AF PD S D + Y I SGN G S+ K+G +T K LD E ++E L V
Sbjct: 1702 SIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV 1760
Query: 1216 TVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVI 1275
+G +V V I DENDN P F Q Y+ + E + + + V
Sbjct: 1761 LAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAH-------VIQVF 1810
Query: 1276 ATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGR 1332
ATD D G N I YSI GN+ F I+ +GV+++K + Y ++ ++A D G
Sbjct: 1811 ATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI-VQATDKGM 1869
Query: 1333 PQKSSTT--RLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLW 1390
P+ S+TT ++ + I+ P+ P E T + V H + V V+ ++
Sbjct: 1870 PRLSNTTVIKVQVTDINDNAPAFLPSEAVE--ITEDSLPGVIVTH-VSVHDVDLNSAFIF 1926
Query: 1391 FDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTN 1450
N + F +D+ TG +++ K LD E+ + Y L ++ +D + ++V+D N
Sbjct: 1927 SFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVN 1986
Query: 1451 DHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPA 1510
D+ P FS Y+V +PE +L +SA D + + Y + SS K+F +DP
Sbjct: 1987 DNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSS-----KEFSIDPK 2041
Query: 1511 TGSLYT-SEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG 1569
G+++T S L + + V D P R + + + D N++AP FT SY
Sbjct: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
Query: 1570 RVYESAAVGSVVLQVTALDKD-KGKNAEVLYSIESGNIGNSFMID----------PVLGS 1618
+ E A VGS ++ + +D D +N V YSI SGN N+F ++ +G
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
Query: 1619 IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSE 1678
+ LDR A ++L++ A+D G PP+S + I V ++ P F+S Y + E
Sbjct: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
Query: 1679 TVSIGSFVGMVTAH-----SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIY 1733
+ +GS + +V+A+ S + ++Y I GN F + ++G + K LD+E + +
Sbjct: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKF 2281
Query: 1734 TLIIQGTNMAGLSTN-TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL 1792
TL +Q ++ + V V + D+ND+AP FM + ++ ++ E+ I+S + +
Sbjct: 2282 TLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICS------ 2335
Query: 1793 VIRAADADKDSNALLVYHIVEPSV--------HTYFAIDSSTGAIHTVLSLDYEETSIFH 1844
I A D D L Y IV P H F ID TG IH LDYE + +
Sbjct: 2336 -INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
Query: 1845 FTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNAT 1904
TVQ D G A + V V + I++ P+F + Y +L + V A+
Sbjct: 2395 LTVQAKDKGD----ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEAS 2450
Query: 1905 DADSSAFSQLIYSITEGNIGEKFSMDYKTGAL-------TVQNTTQLRSRYELTVRA--- 1954
DAD+ ++YS+ G FS++ G + +++ E+ + A
Sbjct: 2451 DADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSP 2508
Query: 1955 -SDGRFAGLTSVKINVKESKE 1974
SD +FA T V +NV S E
Sbjct: 2509 KSDSKFASCT-VFVNVSFSSE 2528
Score = 551 bits (1421), Expect = e-156
Identities = 592/2214 (26%), Positives = 959/2214 (43%), Gaps = 213/2214 (9%)
Query: 1642 KGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEI 1701
K P +E+ +F + +NA P KE V S+ S G + Y +
Sbjct: 50 KRGSPETELWGAIVFRSQEENAKPV---KETEVTASDADS--GLYGFIE--------YSL 96
Query: 1702 KDG----NTGDAFDINPHSGTIITQKALDFETLPI-YTLIIQG--------TNMA----G 1744
DG AF I+PH G I + +D E P Y L+++ T++A G
Sbjct: 97 YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGG 156
Query: 1745 LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSN 1804
LS V V L+D NDN PVF + Y IS+ + ++ + A D D
Sbjct: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN-------VLATDQDSGIY 209
Query: 1805 ALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAAN 1864
+ Y ++ +V + F IDS+TG + S + E S +F+ M + +F +
Sbjct: 210 GTVAYELIPGNVSSLFTIDSTTG----LYSPEVEILSAVNFSADKEVMNSLEMFLPLLRH 265
Query: 1865 VTVHVIDINDCPPVFAKPLYEASL-LLPTYKGVK-----VITVNATDADSSAFSQLIYSI 1918
D A+ +EAS +KG + + A AD A ++ + ++
Sbjct: 266 FKKVERDEEA-----AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANL 320
Query: 1919 TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSV-----KINVKESK 1973
+ +GE + Y T L+ +T L L V A DG GLT+V I++ ++
Sbjct: 321 AK-ILGE--GIIYLTLPLSHLESTTL----SLMVSAQDG--GGLTAVINADVTIHIFQTT 371
Query: 1974 ESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDR--RFKISRTS 2029
+ +F + Y+ +V E+ E + + A P+N EP+FY I + D +F I
Sbjct: 372 LAPAEFERPKYTFLVYEDVPEDSPIGTVKA-REPLNSSEPIFYRISSGDLGGKFSIHPRL 430
Query: 2030 GVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
G + T P D E Q + V+ P A + V + V D NDN P F+
Sbjct: 431 GTIRTR-KPLDHETQPVVVLTVQAQLGSAP-ACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
Query: 2090 VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEH-FQIG-PLGEISLKKQFELDTLN 2147
+ T G + A DRDSGRNG + Y + F I LG + L
Sbjct: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE-Q 547
Query: 2148 KEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMP---VFEKPFYSAEIAESIQVHSPVVHV 2204
+E +T+ A+D G +A +++ + + + FE Y E++ES+ + ++
Sbjct: 548 RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 607
Query: 2205 QANSPEGLK-----VFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS 2259
QA+ P G + + YS+ + F I TG I + D+E+ Y + A
Sbjct: 608 QAH-PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 666
Query: 2260 LTGAHAEVFVDIIVD--DINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRG 2317
G V +IV D NDN P F + + E+ V + ++ A D DS N
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQ 726
Query: 2318 ISYQMF-------------------------GNHSKSHDHFHVDSSTGLISLLRTL---- 2348
+ Y + G + S F S +L++L
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 2349 -----------DYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQI--- 2394
D E H + V D G P ++ + V V VTD+NDN P F Q +
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 2395 -YEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLH 2453
++ E P VT V A D D + ++ YS+ S + HF ID+ G I + +
Sbjct: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
Query: 2454 RHALKPFYSLNLSVSD-GV--FRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTL 2510
+ +P Y +++ +D GV + V++ VI + QN + + EN +
Sbjct: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
Query: 2511 VMEVKTTDGDSGIY-GHVTYHIVNDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRL 2568
+ +K++D Y G + + IV D F I + G +F ++LD ET + + R+
Sbjct: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLF--RV 1024
Query: 2569 MAKDAGGKVAFCT---VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADE 2625
+ D ++ + +++ + D ND++P F+ +++ + GT V A D D+
Sbjct: 1025 ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DD 1083
Query: 2626 GS--NADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVD---NGS 2680
GS N+ I Y IE+ + L I+ G + T L V A D N +
Sbjct: 1084 GSFLNSRIQYYIESHNPGTNPFL-IHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVT 1142
Query: 2681 PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLY 2735
+ + + IL P F F V EDV +G+ + I A +G V Y
Sbjct: 1143 DRRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY 1201
Query: 2736 SLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDV 2795
S++ G N + +F++D SG L LD+E + ++LA + +S +
Sbjct: 1202 SILSG-----NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA-LDDGTPALSSSQTL 1255
Query: 2796 SIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVE 2855
++ V D ND +PVF+ YEA + EN G V ++ A D DSG N ++ + + S E
Sbjct: 1256 TVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE 1315
Query: 2856 VIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSP 2915
+ F IN +TG + T LD E ++ + ++V+ D G LSST + TV D ND
Sbjct: 1316 L---FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDENDHA 1371
Query: 2916 PRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE 2975
P F Y V E+ V +L+ +D D+ NR V Y I G+ F + + E
Sbjct: 1372 PEFIVSSYDIEVLENQEPEVVYTVLA-SDMDAGN-NRAVEYHIIDGNTDECFTINEMSGE 1429
Query: 2976 WKVYVKKPLDREKRDNYLLTITAT---DGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTI 3032
+ + LDRE+ N+ L I + D SS ++V+VLDAND+SP Y ++
Sbjct: 1430 --LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
Query: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAV 3092
ED G +++ +SA D D N + Y L + F ++P +G LKTS LDRE ++
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
Query: 3093 YHLLVRATD---GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
+ A D G R I + + DVNDN P +P+ + + + V+A
Sbjct: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRA 1607
Query: 3150 TDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRR 3209
D D G N +++S ++ FSI++ +G IQ ++ E ++ L LK DQG+P R
Sbjct: 1608 DDLDLGPNGTVVFSFAET-QSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPAR 1665
Query: 3210 LTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSI 3269
T TG +++ ++ D F + Y V+E+ GT ++ V A + D + YSI
Sbjct: 1666 -TTTGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSI 1722
Query: 3270 ISGNEHGKFSIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTD 3327
SGNE G S+ SK+G + + E LD+E +E L V A G + VA V + D
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA---VLIQD 1779
Query: 3328 INDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDP 3387
NDN+P F Q Y +SE + VI V A D D N I YSI+ GNQ +F ID
Sbjct: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
Query: 3388 VRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSV 3447
+ G + +LD E S Y+L VQA+D G P NTT + + V+D+NDNAP F
Sbjct: 1840 LSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVE 1899
Query: 3448 IIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRK 3506
I +++ P G V + V D D N F N F ++ GV++ + +
Sbjct: 1900 ITEDSLP-GVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE 1956
Query: 3507 EKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGK 3566
E Y L ++++D+ +L +RV++ + PP +T G +
Sbjct: 1957 EMTEYELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013
Query: 3567 IHATDQDVYDTLTY---------SLDPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVSVT 3617
+ ATD + + ++Y S+DP+ +F++S ++ + Q+L V +
Sbjct: 2014 LSATDLESNENISYRILSSSKEFSIDPKNGTIFTIS----PVLLLDTISTTQFL--VEAS 2067
Query: 3618 DGKFTTVADIT---VHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVR 3674
DG + +T + I + T+ +L+ + VG F + R
Sbjct: 2068 DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHD--WTR 2125
Query: 3675 RNDIQIVSLQS--SEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEII 3726
N S+ S S+ + H++ F + Q+ LLH ++ + E++
Sbjct: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELV 2179
Score = 499 bits (1286), Expect = e-140
Identities = 543/2112 (25%), Positives = 903/2112 (42%), Gaps = 274/2112 (12%)
Query: 117 TLIVKALEKNTNVEARTKVRVQVLDTNDLRP--LFSPTSYSVSLPENTAIRTSIARVSAT 174
TL ++A ++ + +A V V++ + P F Y V + E+ + T + + A
Sbjct: 551 TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
Query: 175 DADIGTN---GEFYYSFKDRTD--MFAIHPTSGVIVLTGRLDYLETKLYEMEILA--ADR 227
+G YS + D MF I P +G I L + DY T+ Y + A +
Sbjct: 611 P--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 668
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPV-ITAVTLSPSELDRDPAYAI--VTVDDCDQG 284
G S+ + V + N+ +P + V E P I +T D D G
Sbjct: 669 GFLQNVSTTV------IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSG 722
Query: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGG---------------------- 322
NG + + G + + P Y + G
Sbjct: 723 KNGQLLYFLLSDGKFFKM--NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
Query: 323 -----------IDW----DSHPFGYNLTLQAKDKGTPPQ------FSSVKVIHVTSPQFK 361
I+W H + +T+ D+G+PP+ + SV I+ P F
Sbjct: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF- 839
Query: 362 AGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNT 417
P ++ E P N V V A + + Y S F ++ N
Sbjct: 840 --PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
Query: 418 GLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAF 472
G I + + + V +D+ + V ++V+ + +Q
Sbjct: 898 GEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLII 957
Query: 473 DENVPIGTTVMSL--SAVDPDEGENGYVTYSI-ANLNHVPFAIDHFTGAVSTSENLDYEL 529
EN+ T +MSL S+ + NG + +SI A+ F ID TG + S+ LDYE
Sbjct: 958 PENLK-PTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET 1016
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
Y R+ +D V +I + + ND++P F+ ++ ++ +G +
Sbjct: 1017 TSH-YLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVY 1075
Query: 590 TVSAIDADELQL---VQYQIEAGNE-LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRI 645
+A D D L +QY IE+ N + F ++P+ G L + +
Sbjct: 1076 VFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTL------------------VTV 1117
Query: 646 TATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFD 705
+ D E+ T + +TV AS + VN+ + + + A+ ++
Sbjct: 1118 SRLDRESIPT---VILTVTASDQAVNV--TDRRLRSLTAQIVIL---------------- 1156
Query: 706 SHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCF 765
VN H P F S VKE+ VGS V + + D D G NGK+ Y++ GNE+ F
Sbjct: 1157 --DVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
Query: 766 MIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQE 825
M+D +G+L PLD E ++ L + D G P ++ + L V V+D ND P F Q
Sbjct: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQH 1272
Query: 826 SYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVTGVVNIARPL 883
Y V E++ + +VEA D+D G N + + I+ + F I+S TG V L
Sbjct: 1273 LYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL 1332
Query: 884 DRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEG 943
DRE+Q +L++ RD P L ST + ++ED ND+ P FI +Y ++V E+ E
Sbjct: 1333 DREIQEVFTLRVLVRDGG--FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEP 1389
Query: 944 TVIMWLEAHDPDLGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVR 1002
V+ + A D D G + V Y ++D + + F ++++SG + + LD E+ + L +
Sbjct: 1390 EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVIL 1449
Query: 1003 AKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDED 1062
D G P SS +++V V+D N+ H P F + + +V+EDA VG++V+ +SA D+D
Sbjct: 1450 CSDLGDP-PRSSVIHLQVRVLDAND--HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKD 1506
Query: 1063 ARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD---QGVVPL 1119
+G+ Y + D + G F I +G ++TS+ LDRE+ S + + A D QG
Sbjct: 1507 EGLNGQTEYFLTDEAS-GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRST 1565
Query: 1120 SSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKIT 1179
+ I++Y V DVNDN P + + + SP + + V + A D D N +++
Sbjct: 1566 TVIIKVY--VTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF- 1622
Query: 1180 SGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI---LEVTVTDNGSPPKSTIARVIVKIL 1236
Q FSI TG I + + E+ L++ VTD G P ++T +++ +
Sbjct: 1623 -AETQSMFSIDKYTGEI-----QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIH-M 1675
Query: 1237 DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA---EISYSIED 1293
+ D K F YK + E + I T K P++ + YSI
Sbjct: 1676 EGEDVKISFSHHLYKGLVTENCEAGTS-----------IVTVKAFAPDSIQDSMKYSIFS 1724
Query: 1294 GNEHGKFFIEPKTGVVSSKR-----FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISK 1348
GNE G + K+G ++ K F E ++ + R + E +
Sbjct: 1725 GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNS 1784
Query: 1349 PKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVE-PPGIP--LWFDITGGNYDSHFDV 1404
P FE+S + +V ES AH+I V + + G+ + + I GN + F +
Sbjct: 1785 P-------CFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQI 1837
Query: 1405 DKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---TQVFIKVIDTNDHRPQFSTSKY 1461
D +G I LD E S+Y+L V+ATD L T + ++V D ND+ P F S+
Sbjct: 1838 DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE- 1896
Query: 1462 EVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLD 1521
V I ED+ P + +S D D + I++ +P + KF +D TG + + LD
Sbjct: 1897 AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGT--KFAIDQNTGVVVLVKTLD 1954
Query: 1522 HEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
E + ++ L + + D V +VV V D ND+ P F+ Y+ V ES VG V
Sbjct: 1955 FEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSV 2011
Query: 1582 LQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKE---LDRSNQAEYDLMVK 1638
L ++A D + +N + Y I S + F IDP G+I T LD + ++ +V+
Sbjct: 2012 LTLSATDLESNEN--ISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQF--LVE 2065
Query: 1639 ATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVT------AH 1692
A+D G+P + +T V I + +N +P+FT K Y++ LSE +GS + +
Sbjct: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
Query: 1693 SQSSVVYEIKDGNTGDAFDINP---HS-------GTIITQKALDFETLPIYTLIIQGTNM 1742
+ V Y I GN+ + F + HS G ++ +LD E + L+I ++
Sbjct: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDS 2185
Query: 1743 A--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD 1800
LS+ + + + D NDN P F Y + ES + S + V+ A D D
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI-------TVVSANDRD 2238
Query: 1801 KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE 1860
S+A ++Y+I+ + +F ++ +TG ++ + LDYE+ + F TVQ D
Sbjct: 2239 TGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF--- 2295
Query: 1861 YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVK--VITVNATDADSSAFSQLIYSI 1918
A V V V+D ND P F + S ++P + + ++NA D D+ + +L YSI
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSF--SCIVPENLPISSTICSINALDFDAGPYGELTYSI 2353
Query: 1919 TE---------------------GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASD- 1956
G+I K +DY+ G ++Y LTV+A D
Sbjct: 2354 VSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG-----------NKYCLTVQAKDK 2402
Query: 1957 GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA--IGNPINEPLFY 2014
G V ++++ E FTQD Y + E + + + + + A I+ + Y
Sbjct: 2403 GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
Query: 2015 HILNPDRRFKISRTSG-VLSTTGTPFDREQQEAFDVVVEVTEEHKP---SAVAHVVVKVI 2070
+ F +++T+G + P + Q D + H P S A V V
Sbjct: 2463 SLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVN 2522
Query: 2071 VEDQNDNAPVFV 2082
V ++ P+ V
Sbjct: 2523 VSFSSEGTPLAV 2534
Score = 204 bits (519), Expect = 2e-51
Identities = 241/947 (25%), Positives = 388/947 (40%), Gaps = 142/947 (14%)
Query: 28 EQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAE 86
E + F+H Y V EN A T + V + + + ++Y I SG+ + +
Sbjct: 1678 EDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFAPDSIQDSMKYSIFSGNEDGV---- 1730
Query: 87 EYILGDFCFLRIRTKGGNTAI-----LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLD 141
L + +K G + L+ EV++ LIV L +++ A KV V + D
Sbjct: 1731 ---------LSLCSKSGQLTVKEPKFLDFEVRNEVQLIV--LAESSGHRAYCKVAVLIQD 1779
Query: 142 TNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF--KDRTDMFAIHP 199
ND P F + Y S+ E+ + +V ATD D G NG YS ++ + F I
Sbjct: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
Query: 200 TSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA 259
SGVI LDY T Y + + A D+GM +S+ + V + N+ AP
Sbjct: 1840 LSGVITTKAILDYELTSSYSLIVQATDKGM-----PRLSNTTVIKVQVTDINDNAPAFL- 1893
Query: 260 VTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQF---RTVRSFPGSK--- 313
P+ A+ +D G + +S+ DL F S PG+K
Sbjct: 1894 -----------PSEAVEITEDSLPGV--IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
Query: 314 ---EYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFS-SVKVIHVTSPQFKAGPVKFEK 369
V + +D++ Y L +Q D + + V+V+ V P F +
Sbjct: 1941 DQNTGVVVLVKTLDFEEMT-EYELLIQISDSVHYTEGALVVRVLDVND-----NPPVFSQ 1994
Query: 370 DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPV--- 426
D Y+ + E P V+ + A S+ ++ +FS++ G I + PV
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLL 2054
Query: 427 KRQQAAHFELEVT---TSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
F +E + D +A T V + + N+ PEFT +Y + E+ +G+T++
Sbjct: 2055 DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLV 2114
Query: 484 SLSAVDPD-EGENGYVTYSIANLN-----HVPFAIDHF------TGAVSTSENLDYELMP 531
+ S +D D EN YV YSI + N HV H G + +LD E
Sbjct: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
Query: 532 RVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+ L I ASD G P V+ +I + ++NDN P F ++ + +G IT V
Sbjct: 2175 S-HELVILASDSGCPPLSSTAVI-SIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
Query: 592 SAIDADELQLVQ--YQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
SA D D + Y I +GNE F L N+GVL L + L
Sbjct: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPL------------------- 2273
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
++ +TV AS A K H V +F
Sbjct: 2274 --DYEKMTKFTLTVQAS----------------------DAEKKHFSFAV--VFVSVLDD 2307
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSG--------GNE 761
N H PQF + + I V EN P+ S++ +N+ D D G G+L Y++ +
Sbjct: 2308 NDHAPQFMFSSFSCI-VPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYD 2366
Query: 762 DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPE 821
F+ID TG + LD E +KY L + D G A ++ V + ++ P
Sbjct: 2367 HDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPI 2424
Query: 822 FLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIAR 881
F Q+ YF + E + I +VEA+D D G +G + YS+ T + FS++ G + + R
Sbjct: 2425 FTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIR 2484
Query: 882 PL---DRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
L +L E +L+++ + + F++ V V++ ++ P
Sbjct: 2485 ALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
Score = 72.8 bits (177), Expect = 7e-12
Identities = 77/283 (27%), Positives = 114/283 (40%), Gaps = 45/283 (15%)
Query: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
+ P F+ L Y+ V+E++ +++ V T E+ Y I+SG+ + F E
Sbjct: 2203 VNDNPPNFSSLSYHTHVKESTPLGSHIT-VVSANDRDTGSHAEIIYNIISGNEKGHFYLE 2261
Query: 87 EYILGDFCFLRIRTKGGNTAIL------NREVKDHYTLIVKALEKNTNVEARTKVRVQVL 140
E NT +L + E +TL V+A + + V V VL
Sbjct: 2262 E----------------NTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVL 2305
Query: 141 DTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-------- 192
D ND P F +S+S +PEN I ++I ++A D D G GE YS
Sbjct: 2306 DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY 2365
Query: 193 --DMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQA 250
D+F I P +G I LDY Y + + A D+G ++ + V IE
Sbjct: 2366 DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG-------DATASLVVWVDIEGI 2418
Query: 251 NECAPVITA----VTLSPSELDRDPAYAIVTVDDCDQGANGDI 289
+E P+ T TL DR V D D G +G I
Sbjct: 2419 DEFEPIFTQDQYFFTLPEKNKDRQ-LIGRVEASDADAGIDGVI 2460
Score = 54.7 bits (130), Expect = 2e-06
Identities = 56/200 (28%), Positives = 88/200 (44%), Gaps = 13/200 (6%)
Query: 31 PLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL 90
P +F +Y V E+ + +G VK + + + + Y+I SGD F L
Sbjct: 374 PAEFERPKYTFLVYEDVPEDSPIG-TVKAREPL-NSSEPIFYRISSGDLGGKFSIHPR-L 430
Query: 91 GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS 150
G IRT+ L+ E + L V+A + + T+V + V+D ND P F
Sbjct: 431 GT-----IRTRKP----LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481
Query: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-KDRTDMFAIHPTSGVIVLTGR 209
TS + + + T T++ A D D G NG YS + +FAI GV+ L G
Sbjct: 482 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGS 541
Query: 210 LDYLETKLYEMEILAADRGM 229
L E + + + A D+G+
Sbjct: 542 LGAGEQRELTLTLRAEDQGV 561
Score = 47.4 bits (111), Expect = 3e-04
Identities = 27/77 (35%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 129 VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
+ A+ VRV + D ND P+F+P++Y S+ + T T I V ATD D G G Y
Sbjct: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 216
Query: 189 --KDRTDMFAIHPTSGV 203
+ + +F I T+G+
Sbjct: 217 IPGNVSSLFTIDSTTGL 233
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 499 bits (1286), Expect = e-140
Identities = 419/1475 (28%), Positives = 658/1475 (44%), Gaps = 170/1475 (11%)
Query: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRA-----EHSGTVLYSLVKGNTPESNRDESFVIDR 2755
P+F P Y TV E+ P GT + +RA +G + Y++ +S ++ F +D
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM--DALFDSRSNQFFSLDP 236
Query: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMV---ASVDVSIQVKDANDNSPVFESS 2812
+G + + LD ET + F R T DH M A ++I V D ND+ PVFE
Sbjct: 237 VTGAVTTAEELDRETKSTHVF----RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292
Query: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTL 2872
Y+ + ENL G V+ +RA+D D+ N ++Y L + E F I+ +G I T
Sbjct: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTR 352
Query: 2873 KELDHEKRDNYQIKVVASDHG-EKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD 2931
+D E+ ++YQ+ V ASD G + S+TA V ++V D ND+ P+F+ + Y V ED
Sbjct: 353 GPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 2932 PQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991
G + ++ +D D N V Y I G+ GQF ++ + V PLD E
Sbjct: 413 TPGAPVLRVTASDRDKGS-NAVVHYSIMSGNARGQFYLDA--QTGALDVVSPLDYETTKE 469
Query: 2992 YLLTITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISA 3047
Y L + A DG + +V V+VLD NDN+P+ T + T+ E V G L++ + A
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
Query: 3048 TDADIRSNAEITYTLLGSGAE-KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG--G 3104
DAD NA + Y L G G + F +N TG + + LDREE Y V A D G
Sbjct: 530 IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA 589
Query: 3105 RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL 3164
AS+ +T+ DVNDN P F+ Y + + E+ GT + V A D DA + I Y +
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
Query: 3165 ID-SADGQFSINELSG--IIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL 3221
+ +FSI SG ++ L PLD +L+ Y L++ A D T ++V+V
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG----TRQDTAQIVVNVT 703
Query: 3222 DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSID 3281
D N + PVF+ Y V+ED GT V+ + A D NA ITY + + +F ID
Sbjct: 704 DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRID 761
Query: 3282 SKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYT 3341
+ TGAV LDYE Y L + A D G P SD + + V D+NDN P F +D+Y
Sbjct: 762 ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
Query: 3342 TVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDPVRGEVKVTKLLDR 3400
+ ED SV+ + A D D N + Y+ G+ G F ++ G V+ + LDR
Sbjct: 822 GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDR 881
Query: 3401 ETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVL 3460
E ++ Y L A D G PP V + V DVNDN PVF + + V ++EN P+G +V
Sbjct: 882 ENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941
Query: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD 3519
++ TD D N + IV GN + F+++ G L + +++ Y+L ++
Sbjct: 942 RVTATDPDEGTNAQ-IMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS 1000
Query: 3520 NGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSGGVIGKIHATDQDVY 3575
P +S T + +R+++ + PP + EI ++T+ + GG IG++ A D D+
Sbjct: 1001 --APLVSRAT-VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDIS 1057
Query: 3576 DTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIGQYL---LNVSVTDGKFTTVADITVHI 3631
D+LTYS + + +L ++++ G+L + LD + L ++V V+DG + A + +
Sbjct: 1058 DSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRV 1117
Query: 3632 RQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEPHPH 3691
+T EML H+I +R +++PE F+ F +A+ L + + + ++Q P
Sbjct: 1118 TIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPG 1177
Query: 3692 ---LDVLLFVEKP-----GSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDC 3743
L+V L V +P G + ++ L ++ + + + I R+L +C C
Sbjct: 1178 GHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPC 1237
Query: 3744 P-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHG--------- 3793
+ C + D S S++ L P H + RCPP G
Sbjct: 1238 ENYMRCVSVLRFDSSAPFIASSSVL--FRPIHPVGGL----RCRCPPGFTGDYCETEVDL 1291
Query: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ---------------------------- 3825
C PC C S E +TC+C G G+
Sbjct: 1292 CYSRPCGPHGRCRSR--EGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVG 1349
Query: 3826 -----CPGS---------SSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMY- 3870
CP ++ + +S++ +R + L + T +++Y
Sbjct: 1350 GFKCDCPSGDFEKPYCQVTTRSFPAHSFITFR--GLRQRFHFTLALSFATKERDGLLLYN 1407
Query: 3871 ---ARGTDYSILEIHHGRLQYKFDCGSGPGIVS-VQSIQVNDGQWHAVALE--------- 3917
D+ LE+ ++Q F G VS V+DGQWH V L+
Sbjct: 1408 GRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQ 1467
Query: 3918 ----------------VNG-------NYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGG 3954
V+G + ++ + A GT G+ K+L+L + GG
Sbjct: 1468 TGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGG 1527
Query: 3955 HIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTAT 4014
+ R Q F GCM + L ++S+ A + PGC
Sbjct: 1528 VPDLPESFPVRMRQ----FVGCM-------RNLQVDSRHIDMADFIANNGTVPGC-PAKK 1575
Query: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHC 4049
C SN C NGG C + + C+C + G C
Sbjct: 1576 NVCDSNTCHNGGTC-VNQWDAFSCECPLGFGGKSC 1609
Score = 464 bits (1194), Expect = e-130
Identities = 321/947 (33%), Positives = 482/947 (50%), Gaps = 41/947 (4%)
Query: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI--VNDFAKDRFYINE-- 2544
+P F Y+ + EN P T V ++ D D G G + Y + + D ++F+ +
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 2545 RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604
G + T E+LDRET + V V + A T+ +++TD ND+ P F +Y+ +
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 2605 IGSSAAKGTSVVKVLASDADEGSNADITY-AIEADSESVKENLEINKLSGVITTKESLIG 2663
+ + G V+ V A+D D NA+I Y +E S E EI+ SGVI T+ +
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
Query: 2664 LENEFFTFFVRAVDNGSP--SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTE 2721
E E + V A D G + + V++ + P+FSE Y V EDV G
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 2722 IDLIRAE-----HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF 2776
+ + A + V YS++ GN F +D Q+G L + LD+ETTK Y
Sbjct: 418 VLRVTASDRDKGSNAVVHYSIMSGNA-----RGQFYLDAQTGALDVVSPLDYETTKEYTL 472
Query: 2777 SILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDA 2836
+ A+ S V++QV D NDN+P+F S+P++A ++E++P G V+ ++A DA
Sbjct: 473 RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 2837 DSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKI 2896
D+G N ++ Y L V F IN TGWI+ ELD E+ D Y V A DHG
Sbjct: 533 DAGDNARLEYRL---AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTP- 588
Query: 2897 QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTY 2956
L+++A V VTV DVND+ P FT Y ++ED G + +S D D+ + +TY
Sbjct: 589 ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV---ITY 645
Query: 2957 FITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDA 3016
IT G+ +F++ + V + PLD + Y+L +TA+DGT A + V V DA
Sbjct: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDA 705
Query: 3017 NDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDT 3076
N + PV + + Y+ + ED G ++ ISATD D NA ITY + +F+++ DT
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMEDSIPQFRIDADT 764
Query: 3077 GELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITV 3134
G + T LD E+Q Y L + A D G + + + + DVNDNAP+F D Y +V
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSV 824
Query: 3135 FENTEPGTLLTRVQATDADAGLNRKILYSLI--DSADGQFSINELSGIIQLEKPLDRELQ 3192
+E+ P T + ++ ATD D+GLN ++ Y+ D DG F + SGI++ + LDRE
Sbjct: 825 YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENV 884
Query: 3193 AVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQV 3252
A Y L AVD+G+P T V V+VLD+NDNPPVFE E+ V E+ +G V +V
Sbjct: 885 AQYVLRAYAVDKGMPPARTPM-EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Query: 3253 YAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGT 3312
A D NA+I Y I+ GN F +D +G + + +LDYE EY L ++AT +
Sbjct: 944 TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---S 1000
Query: 3313 PSLSDVATVNVNVTDINDNTPVFSQ-----DTYTTVISEDAVLEQSVITVMADDADGPSN 3367
L ATV+V + D NDN PV + Y T S + ++ V A D D +
Sbjct: 1001 APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRS-SSFPGGAIGRVPAHDPD--IS 1057
Query: 3368 SHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
+ YS GN+ S ++ GE+K+++ LD ++V SD
Sbjct: 1058 DSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 428 bits (1101), Expect = e-119
Identities = 314/973 (32%), Positives = 476/973 (48%), Gaps = 62/973 (6%)
Query: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL--LDHGEGN--FDVDKLS 980
P F PP+Y+ V E+ P GT + L A DPD G++G++ Y++ L N F +D ++
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 981 GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
GAV ++LD E K + V A+D G P S+ + + V D N+ H PVF K
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTND--HDPVFEQQEYK 295
Query: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG---VFKIGEETGVIETSDRL 1097
+++E+ VG V+TV A D DA + I Y + +GSG VF+I +GVI T +
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 1098 DRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
DRE Y LTV A+DQG P S+ +++ VED NDNAPQ SE Y ++ E+
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEV 1215
V+++ A D D SN + Y I SGN +G F + +TG + S LD E E+ L V
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS-PLDYETTKEYTLRV 474
Query: 1216 TVTDNGSPPKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPL--- 1271
D G PP S ++ ++ V++LD NDN P F+ ++ + E PL
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE-----------SVPLGYL 523
Query: 1272 -YHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILS--IKAV 1328
HV A D D G NA + Y + F I TG +S E D S ++A
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV--EPPG 1386
D+G P +++ + + + + +F + +T + E V + +S
Sbjct: 584 DHGTPALTASASVSVTVLDVNDNN---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH 640
Query: 1387 IPLWFDITGGNYDSHFDV--DKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFI 1444
+ + IT GN + F + G G + +A PLD + + Y L V A+DGT Q+ +
Sbjct: 641 SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVV 700
Query: 1445 KVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSL 1502
V D N HRP F +S Y V + ED T ++ ISA D+D E ++ Y ++ S+
Sbjct: 701 NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-----SI 755
Query: 1503 KKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWF 1562
+FR+D TG++ T +LD+E +TL + RD +P K + + + V+D ND+AP F
Sbjct: 756 PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
Query: 1563 TASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMIDPVLGSIKT 1621
SY+G VYE + VLQ++A D+D G N V Y+ + G+ G+ F+++ G ++T
Sbjct: 816 LRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
Query: 1622 AKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVS 1681
+ LDR N A+Y L A DKG PP V + V ++ P F E+ V + E
Sbjct: 876 LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
Query: 1682 IGSFVGMVTA-----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLI 1736
IG V VTA + + ++Y+I +GN + F ++ SG + LD+E P Y L+
Sbjct: 936 IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
Query: 1737 IQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVP--LVI 1794
IQ T+ A L + TV V L D NDN PV E N V + P +
Sbjct: 996 IQATS-APLVSRATVHVRLLDRNDNPPVLGNFEI-------LFNNYVTNRSSSFPGGAIG 1047
Query: 1795 RAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGT 1854
R D D + L Y + + +++STG + +LD +V V D G
Sbjct: 1048 RVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GV 1106
Query: 1855 PRLFAEYAANVTV 1867
+ A+ A VT+
Sbjct: 1107 HSVTAQCALRVTI 1119
Score = 390 bits (1001), Expect = e-107
Identities = 293/953 (30%), Positives = 467/953 (49%), Gaps = 48/953 (5%)
Query: 2591 DNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA--DSESVKENLEI 2648
+ APQF+ Y+ + + GT V + A D DEG + Y ++A DS S + +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS-NQFFSL 234
Query: 2649 NKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFY 2708
+ ++G +TT E L F V A D+G P + ++ + + + P F + Y
Sbjct: 235 DPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 2709 TFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE 2763
++ E++ +G E+ +RA + +LY L++G+ + E F ID +SG ++
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSG--GSPSEVFEIDPRSGVIRTR 352
Query: 2764 KSLDHETTKWYQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENL 2822
+D E + YQ ++ A +D + V + V+D NDN+P F Y + E++
Sbjct: 353 GPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 2823 PGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDN 2882
G+ V+++ ASD D G+N V YS+ S F ++ +TG + + LD+E
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSI---MSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
Query: 2883 YQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILST 2942
Y ++V A D G + + +V V V D+ND+ P F + ++ TV E P G ++ +
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
Query: 2943 TDADSEEINRQVTYFITGGDPLGQFAVETIQNE--WKVYVKKPLDREKRDNYLLTITATD 3000
DAD+ + N ++ Y + G +G TI N W + V LDRE+ D Y + A D
Sbjct: 530 IDADAGD-NARLEYRLAG---VGHDFPFTINNGTGW-ISVAAELDREEVDFYSFGVEARD 584
Query: 3001 -GT--FSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAE 3057
GT ++ A V V VLD NDN+P + Y+ + ED G ++ +SA D D S
Sbjct: 585 HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--V 642
Query: 3058 ITYTLL-GSGAEKFKLNPDTGE--LKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLT 3114
ITY + G+ +F + +G + + PLD + + Y L V A+DG R A IV+
Sbjct: 643 ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT-RQDTAQIVVN 701
Query: 3115 LEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSI 3174
+ D N + P F + Y + V E+ GT + + ATD D G N +I Y + DS QF I
Sbjct: 702 VTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRI 760
Query: 3175 NELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYRE 3234
+ +G + + LD E Q YTL++ A D G+P++ T I+ V D+NDN P F
Sbjct: 761 DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL-VNDVNDNAPQFLRDS 819
Query: 3235 YGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE-HGKFSIDSKTGAVFIIENL 3293
Y +V ED+ T VLQ+ A RD N + Y+ G++ G F ++S +G V + L
Sbjct: 820 YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
Query: 3294 DYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQS 3353
D E+ +Y L A D G P V V V D+NDN PVF QD + + E++ + +
Sbjct: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
Query: 3354 VITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQAS 3413
V V A D D +N+ I Y I++GN F +D GE+ LD E Y L +QA+
Sbjct: 940 VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
Query: 3414 DNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQE---NKPVGF---SVLQLVVTDE 3467
S P V+ TV++ + D NDN PV GN+ ++ N+ F ++ ++ D
Sbjct: 1000 ---SAPLVSRATVHVRLLDRNDNPPVL--GNFEILFNNYVTNRSSSFPGGAIGRVPAHDP 1054
Query: 3468 DSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVAD 3519
D S + ++ GN+ +N G L S A+ ++ V V+D
Sbjct: 1055 DISDS---LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 385 bits (988), Expect = e-106
Identities = 319/1030 (30%), Positives = 483/1030 (46%), Gaps = 92/1030 (8%)
Query: 461 PEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANL----NHVPFAIDHFT 516
P+F +Y+A EN P GT V SL A+DPDEGE G + Y++ L ++ F++D T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 517 GAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEG 576
GAV+T+E LD E + R+ A D G+P R + L TI + + ND+ P+FE+ +
Sbjct: 239 GAVTTAEELDRETKS-THVFRVTAQDHGMPRRSALATL-TILVTDTNDHDPVFEQQEYKE 296
Query: 577 TIPRDLGVGEQITTVSAIDAD---ELQLVQYQIEA--GNELDFFSLNPNSGVLSLKRSLM 631
++ +L VG ++ TV A D D ++ +E G+ + F ++P SGV+ R +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT-RGPV 355
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
D +V + L + A+D P T AA
Sbjct: 356 DR--EEVESYQLTVEASDQGRDPGP---RSTTAA-------------------------- 384
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+F N + PQF S +QV+E+ G+ V+ + ++D D G N
Sbjct: 385 ----------VFLSVEDDNDNAPQF-SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA-AWRLLHV 810
+ Y++ GN F +D +TG L ++SPLD ETT +YTL + D G P + L+ V
Sbjct: 434 VHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTV 493
Query: 811 VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI--VTDTDTF 868
V+D NDN P F+ + V E + ++ V+A D D G N + Y + V F
Sbjct: 494 QVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
+I++ TG +++A LDRE +S +EARD P L ++ V V++ DVNDN PTF
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGT--PALTASASVSVTVLDVNDNNPTFT 611
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGA--VRI 985
P Y V++ ED GT ++ + A D D + Y + N F + SG V +
Sbjct: 612 QPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSL 669
Query: 986 VQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKE 1045
LD++ ++ Y L V A D + T + V V D N H PVF S V E
Sbjct: 670 ALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT--HRPVFQSSHYTVNVNE 723
Query: 1046 DAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHY 1105
D P G+ V+ +SA DED + I Y + D + F+I +TG + T LD E Y
Sbjct: 724 DRPAGTTVVLISATDEDTGENARITYFMEDS--IPQFRIDADTGAVTTQAELDYEDQVSY 781
Query: 1106 WLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFD 1165
L + A D G+ S + I V DVNDNAPQ Y + E+ P SV+QI A D
Sbjct: 782 TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 1166 PDSSSNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP 1224
DS N ++ Y G+ G F + +G++ T R+LDRE +++L D G PP
Sbjct: 842 RDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVAQYVLRAYAVDKGMPP 900
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
T V V +LD NDN P F Q + + E P AR V ATD DEG N
Sbjct: 901 ARTPMEVTVTVLDVNDNPPVFEQDEFDV-FVEENSPIGLAVAR------VTATDPDEGTN 953
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSS---KRFSAAGEYDILSIKAVDNGRPQKSSTTRL 1341
A+I Y I +GN F ++ +G +++ + EY +L I+A P S T +
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY-VLVIQA--TSAPLVSRAT-V 1009
Query: 1342 HIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGI--PLWFDITGGNY 1398
H+ + + +FE F + S IG + P I L + GN
Sbjct: 1010 HVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNE 1069
Query: 1399 DSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKV-IDTNDHRPQFS 1457
S ++ TG + +++ LD + ++V +DG ++ Q ++V I T++
Sbjct: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSI 1129
Query: 1458 TSKYEVVIPE 1467
T + E + PE
Sbjct: 1130 TLRLEDMSPE 1139
Score = 384 bits (987), Expect = e-106
Identities = 298/1011 (29%), Positives = 498/1011 (49%), Gaps = 72/1011 (7%)
Query: 714 PQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY---AVSGGNEDSCFMIDME 770
P +++T+P ENQP G+ V + + D D G G+L Y A+ + F +D
Sbjct: 184 PSYQATVP------ENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 771 TGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVE 830
TG + LDRET + +T D G+P+++A L ++V D ND+ P F Q+ Y
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 831 VSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDR 885
+ E+ EV E++ V ATD D PN ++ Y ++ + ++ F ID +GV+ P+DR
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
Query: 886 ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTV 945
E + L +EA DQ R+ +T V +S+ED NDN P F Y V+VRED+ G
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 946 IMWLEAHDPDLGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
++ + A D D G + V YS++ + G F +D +GA+ +V LD+E + Y L VRA+
Sbjct: 418 VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
D G+P + + V V+V+D+N+N P+F S + TV E P+G LV+ V A D DA
Sbjct: 478 DGGRPPLSNVSGLVTVQVLDINDN--APIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 1065 RDGEIRYSIRDGSGVG---VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSS 1121
+ + Y + +GVG F I TG I + LDRE Y V A D G L++
Sbjct: 536 DNARLEYRL---AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
Query: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181
+ + V DVNDN P ++P Y + E++ SVV + A D D+ S + Y+ITSG
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITSG 650
Query: 1182 NPQGFFSIHPKT-GLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
N + FSI ++ G + + + LD + + +++L VT +D + A+++V + D N
Sbjct: 651 NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANT 707
Query: 1241 NKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKF 1300
++P F Y + + E DR + + ATD+D G NA I+Y +ED +F
Sbjct: 708 HRPVFQSSHYTVNVNE----DRPAGT---TVVLISATDEDTGENARITYFMEDSIP--QF 758
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
I+ TG V+++ A +Y+ L+I A DNG PQKS TT ++E + P
Sbjct: 759 RIDADTGAVTTQ---AELDYEDQVSYTLAITARDNGIPQKSDTT--YLEILVNDVNDNAP 813
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVE-PPGI--PLWFDITGG-NYDSHFDVDKGTGTI 1411
+S+ + P ++ + + + G+ +++ GG + D F V+ +G +
Sbjct: 814 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
Query: 1412 IVAKPLDAEQKSNYNLTVEATD-GTTTILT--QVFIKVIDTNDHRPQFSTSKYEVVIPED 1468
+ LD E + Y L A D G T +V + V+D ND+ P F +++V + E+
Sbjct: 874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+ + +++A D DE +++Y + P + F+LD +G L LD+E
Sbjct: 934 SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRP 990
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVY----ESAAVGSVVL 1582
++ L + + + A + V + D ND+ P Y S+ G +
Sbjct: 991 EYVLVIQATSAPLVSR---ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIG 1047
Query: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642
+V A D D + + YS E GN + +++ G +K ++ LD + E + V +D
Sbjct: 1048 RVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD- 1104
Query: 1643 GSPPMSEITSVRIFVTIADNASPKFTSK--EYSVELSETVSIGSFVGMVTA 1691
G ++ ++R+ + + + T + + S E + +G F+ V A
Sbjct: 1105 GVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAA 1155
Score = 373 bits (958), Expect = e-102
Identities = 302/950 (31%), Positives = 476/950 (50%), Gaps = 61/950 (6%)
Query: 2281 PVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFG-NHSKSHDHFHVDSST 2339
P F SY T+ E GT V +RA D D + Y M S+S+ F +D T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2340 GLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARI 2399
G ++ LD E H V A D GMP S+ +T+ VTD ND+ P+FEQQ Y+ +
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 2400 SEHAPHGHFVTCVKAYDADSSDIDKLQYSIL---SGNDHKHFVIDSATGII-TLSNLHRH 2455
E+ G+ V V+A D D+ + Y +L G+ + F ID +G+I T + R
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
Query: 2456 ALKPFYSLNLSVSD-----GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTL 2510
++ Y L + SD G ++ V ++V N ++P F + Y V++ E+
Sbjct: 359 EVES-YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 2511 VMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLDRETPAEKVISVRLM 2569
V+ V +D D G V Y I++ A+ +FY++ + G + + LD ET E + VR
Sbjct: 418 VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR-- 475
Query: 2570 AKDAGGKVAFCTVNVILT----DDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADE 2625
A+D GG+ V+ ++T D NDNAP F +T ++ + S G V+ V A DAD
Sbjct: 476 AQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 2626 GSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKES 2685
G NA + Y + IN +G I+ L E +F++F V A D+G+P+ +
Sbjct: 535 GDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
Query: 2686 VVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVLYSLVKGNT 2742
V V +L P F++P YT ++ED +GT + + A + + Y + GNT
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNT 652
Query: 2743 PESNRDESFVIDRQS--GRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVK 2800
NR F I QS G + L LD++ + Y ++ T D + + + V
Sbjct: 653 --RNR---FSITSQSGGGLVSLALPLDYKLERQYVLAV----TASDGTRQDTAQIVVNVT 703
Query: 2801 DANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESF 2860
DAN + PVF+SS Y + E+ P G+ V+ I A+D D+G N ++ Y ++ S I F
Sbjct: 704 DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDS-----IPQF 758
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
I+ +TG +TT ELD+E + +Y + + A D+G Q S T +++ V DVND+ P+F
Sbjct: 759 RIDADTGAVTTQAELDYEDQVSYTLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLR 817
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDP-LGQFAVETIQNEWKVY 2979
+ Y+G+V ED P + +S TD DS +N +V Y GGD G F VE+ V
Sbjct: 818 DSYQGSVYEDVPPFTSVLQISATDRDS-GLNGRVFYTFQGGDDGDGDFIVESTSG--IVR 874
Query: 2980 VKKPLDREKRDNYLLTITATD-GTFSSKAIVE--VKVLDANDNSPVCEKTLYSDTIPEDV 3036
+ LDRE Y+L A D G ++ +E V VLD NDN PV E+ + + E+
Sbjct: 875 TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
Query: 3037 LPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAVYHL 3095
G + +++ATD D +NA+I Y ++ G+ E F+L+ +GEL LD E++ Y L
Sbjct: 935 PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
Query: 3096 LVRATDGGGRFCQASIVLTLEDVNDNAP-----EFSADPYAITVFENTEPGTLLTRVQAT 3150
+++AT +A++ + L D NDN P E + Y +T ++ PG + RV A
Sbjct: 995 VIQAT-SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAH 1052
Query: 3151 DADAGLNRKILYSLIDSAD-GQFSINELSGIIQLEKPLD--RELQAVYTL 3197
D D ++ + YS + +N +G ++L + LD R L+A+ ++
Sbjct: 1053 DPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
Score = 373 bits (957), Expect = e-102
Identities = 299/1016 (29%), Positives = 487/1016 (47%), Gaps = 78/1016 (7%)
Query: 2076 DNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL-----KEHHEHFQIG 2130
+ AP F Y A V + G + + A+D D G G + Y + ++ F +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 2131 PL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFS--AEVIVPITVMNKAMPVFEKPFY 2187
P+ G ++ ++ + +T ++ V A+D G P S A + + +T N PVFE+ Y
Sbjct: 236 PVTGAVTTAEELDRET-KSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 2188 SAEIAESIQVHSPVVHVQA---NSPEGLKVFYSITD---GDPFSQFTINFNTGVINVIAP 2241
+ E+++V V+ V+A ++P + Y + + G P F I+ +GVI P
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 2242 LDFEAHPAYKLSIRATD-----SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEAS 2296
+D E +Y+L++ A+D A VF+ V+D NDN P F+++ Y V + E
Sbjct: 355 VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLS--VEDDNDNAPQFSEKRYVVQVREDV 412
Query: 2297 VIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQH 2356
G V++V A+D D N + Y + +++ F++D+ TG + ++ LDYE ++++
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARG--QFYLDAQTGALDVVSPLDYETTKEY 470
Query: 2357 TIFVRAVDGGMPTLSS-DVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
T+ VRA DGG P LS+ +VTV V D+NDN P+F ++A + E P G+ V V+A
Sbjct: 471 TLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD---GVF 2472
DAD+ D +L+Y + F I++ TG I+++ FYS + D
Sbjct: 531 DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
+S V VTV+ N ++P F Q EY V L E+A + T V+ V D D+ + +TY I
Sbjct: 591 TASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQIT 648
Query: 2533 NDFAKDRFYINER---GQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDD 2589
+ ++RF I + G + LD + + V++V A D G + + V +TD
Sbjct: 649 SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAV--TASD-GTRQDTAQIVVNVTDA 705
Query: 2590 NDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEIN 2649
N + P F+++ Y VN+ GT+VV + A+D D G NA ITY +E +S+ + I+
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME---DSIPQ-FRID 761
Query: 2650 KLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYT 2709
+G +TT+ L + +T + A DNG P K + + + P+F Y
Sbjct: 762 ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
Query: 2710 FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEK 2764
+V EDVP T + I A +G V Y+ G+ + D F+++ SG ++ +
Sbjct: 822 GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD----DGDGDFIVESTSGIVRTLR 877
Query: 2765 SLDHETTKWYQFSILARCTQDDHEMVAS---VDVSIQVKDANDNSPVFESSPYEAFIVEN 2821
LD E Y + R D M + ++V++ V D NDN PVFE ++ F+ EN
Sbjct: 878 RLDRENVAQY----VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
Query: 2822 LPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRD 2881
P G V ++ A+D D GTN Q+MY + + EV F +++ +G +T L +LD+E R
Sbjct: 934 SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV---FQLDIFSGELTALVDLDYEDRP 990
Query: 2882 NYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPP-----RFTAEIYKGTVSEDDPQGGV 2936
Y + + A+ L S A V V + D ND+PP Y S P GG
Sbjct: 991 EYVLVIQAT----SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGA 1045
Query: 2937 IAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTI 2996
I + D D I+ +TY G+ L + E K + + LD + ++++
Sbjct: 1046 IGRVPAHDPD---ISDSLTYSFERGNELSLVLLNASTGELK--LSRALDNNRPLEAIMSV 1100
Query: 2997 TATDGTFSSKAIVEVKVLDANDNSPVCEKTL-YSDTIPEDVLP---GKLIMQISAT 3048
+DG S A ++V D TL D PE L G I ++AT
Sbjct: 1101 LVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAAT 1156
Score = 369 bits (946), Expect = e-101
Identities = 282/937 (30%), Positives = 443/937 (47%), Gaps = 56/937 (5%)
Query: 820 PEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSIDSVT 874
P+F SY V E++ + + + A D D G G + Y++ D+ FS+D VT
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 875 GVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRV 934
G V A LDRE + H ++ A+D +T+ + V+ D ND+ P F Y+
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVT--DTNDHDPVFEQQEYKE 296
Query: 935 KVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN----FDVDKLSGAVRIVQQLD 990
+RE+L G ++ + A D D + + Y LL+ G+ F++D SG +R +D
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 991 FEKKQVYNLTVRAKDKGK-PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV 1049
E+ + Y LTV A D+G+ P S+T V + V D N+N P FS V+ED
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN--APQFSEKRYVVQVREDVTP 414
Query: 1050 GSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109
G+ V+ V+A D D + + YSI G+ G F + +TG ++ LD E+T Y L V
Sbjct: 415 GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
Query: 1110 FATDQGVVPLSSFIE-IYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDS 1168
A D G PLS+ + ++V D+NDNAP + ++E+ P V+ ++A D D+
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 1169 SSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTI 1228
N +L Y++ F+I+ TG I+ + +LDRE+ D + V D+G+P +
Sbjct: 535 GDNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPALTAS 593
Query: 1229 ARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEIS 1288
A V V +LD NDN P F Q Y +RL E A + V A D+D ++ I+
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRL-------NEDAAVGTSVVTVSAVDRD--AHSVIT 644
Query: 1289 YSIEDGNEHGKFFIEPKTG-----VVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI 1343
Y I GN +F I ++G + + +Y +L++ A D G Q ++ +++
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQY-VLAVTASD-GTRQDTAQIVVNV 702
Query: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDS--H 1401
+ +P F+ S +T V E P + +IS IT DS
Sbjct: 703 TDANTHRP-----VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
Query: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFST 1458
F +D TG + LD E + +Y L + A D + T + I V D ND+ PQF
Sbjct: 758 FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLR 817
Query: 1459 SKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYT 1516
Y+ + ED P T +LQISA D+D ++ YT Q D F ++ +G + T
Sbjct: 818 DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDD--GDGDFIVESTSGIVRT 875
Query: 1517 SEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576
+LD E V Q+ L D+ +P R + V V D ND+ P F + V E++
Sbjct: 876 LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
Query: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
+G V +VTA D D+G NA+++Y I GNI F +D G + +LD ++ EY L+
Sbjct: 936 IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSF----VGMVTAH 1692
++AT S P+ +V + + ++ P + E T SF +G V AH
Sbjct: 996 IQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
Query: 1693 S---QSSVVYEIKDGNTGDAFDINPHSGTIITQKALD 1726
S+ Y + GN +N +G + +ALD
Sbjct: 1053 DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 348 bits (894), Expect = 5e-95
Identities = 288/1003 (28%), Positives = 458/1003 (45%), Gaps = 113/1003 (11%)
Query: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYS----FKDRTDMF-AIHPTS 201
P F P SY ++PEN T +A + A D D G G Y+ F R++ F ++ P +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 202 GVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261
G + LD + + A D GM S++A LT+ + N+ PV
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRR-----SALATLTILVTDTNDHDPVFEQQE 293
Query: 262 LSPSELDR-DPAYAIVTV--DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318
S + + Y ++TV D D N +I ++ G P S + +
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANIL-YRLLEGSGGSPSEVFEIDPRSGVIRTR 352
Query: 319 AIGGIDWDSHPFGYNLTLQAKDKGTPP-QFSSVKVIHVTSPQFKAGPVKFEKDVYRAEIS 377
G +D + Y LT++A D+G P S+ + ++ +F + Y ++
Sbjct: 353 --GPVDREEVE-SYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 378 EFAPPNTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH 433
E P PV+ V A + + + Y S + +F L+ TG + ++ P+ +
Sbjct: 410 EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
Query: 434 FELEVTTSD------RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487
+ L V D S V V+VL N N P F T ++A E+VP+G V+ + A
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
Query: 488 VDPDEGENGYVTYSIANLNH-VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
+D D G+N + Y +A + H PF I++ TG +S + LD E + Y+ + A D G P
Sbjct: 530 IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD-FYSFGVEARDHGTP 588
Query: 547 YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQI 606
++T+ ++NDN P F + + D VG + TVSA+D D ++ YQI
Sbjct: 589 -ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQI 647
Query: 607 EAGNELDFFSLNPNS--GVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PLYINITV 663
+GN + FS+ S G++SL L L + + L +TA+DG T + +N+T
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ---YVLAVTASDGTRQDTAQIVVNVTD 704
Query: 664 AASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTG 723
A +H+ P F+S+ T
Sbjct: 705 ANTHR---------------------------------------------PVFQSSHYT- 718
Query: 724 IQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC--FMIDMETGMLKILSPLD 781
+ V E++P G++V+ +++TD DTG N ++ Y + EDS F ID +TG + + LD
Sbjct: 719 VNVNEDRPAGTTVVLISATDEDTGENARITYFM----EDSIPQFRIDADTGAVTTQAELD 774
Query: 782 RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841
E YTL IT D GIPQK+ L ++V D NDN P+FL++SY V ED + +
Sbjct: 775 YEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
Query: 842 IQVEATDKDLGPNGHVTYSIVTDTD---TFSIDSVTGVVNIARPLDRELQHEHSLKIEAR 898
+Q+ ATD+D G NG V Y+ D F ++S +G+V R LDRE ++ L+ A
Sbjct: 835 LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
Query: 899 DQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ 958
D+ P + + V V++ DVNDNPP F + V V E+ P G + + A DPD G
Sbjct: 895 DKGM--PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
Query: 959 SGQVRYSLLDHGEGN----FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014
+ Q+ Y ++ EGN F +D SG + + LD+E + Y L ++A L S
Sbjct: 953 NAQIMYQIV---EGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS----APLVS 1005
Query: 1015 TCYVEVEVVDVNENLHPPVFSSFV----EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIR 1070
V V ++D N+N PPV +F T + + G + V AHD D +
Sbjct: 1006 RATVHVRLLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDI--SDSLT 1061
Query: 1071 YSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD 1113
YS G+ + + + TG ++ S LD ++V +D
Sbjct: 1062 YSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 347 bits (891), Expect = 1e-94
Identities = 249/741 (33%), Positives = 375/741 (50%), Gaps = 56/741 (7%)
Query: 2913 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINR-QVTYFITGGDPLGQF-AVE 2970
++ P+F Y+ TV E+ P G +A L D D E R + T QF +++
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 2971 TIQNEWKVYVKKPLDREKRDNYLLTITATDGTF---SSKAIVEVKVLDANDNSPVCEKTL 3027
+ V + LDRE + ++ +TA D S+ A + + V D ND+ PV E+
Sbjct: 236 PVTGA--VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293
Query: 3028 YSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL----GSGAEKFKLNPDTGELKTST 3083
Y +++ E++ G ++ + ATD D NA I Y LL GS +E F+++P +G ++T
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 3084 PLDREEQAVYHLLVRATDGGG----RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTE 3139
P+DREE Y L V A+D G R A++ L++ED NDNAP+FS Y + V E+
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
Query: 3140 PGTLLTRVQATDADAGLNRKILYSLID-SADGQFSINELSGIIQLEKPLDRELQAVYTLS 3198
PG + RV A+D D G N + YS++ +A GQF ++ +G + + PLD E YTL
Sbjct: 414 PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
Query: 3199 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD 3258
++A D G P +G V V VLDINDN P+F + ATV E + +G VL V A D
Sbjct: 474 VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 3259 IEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDV 3318
NA + Y + F+I++ TG + + LD E Y VEA D GTP+L+
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
Query: 3319 ATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGN 3378
A+V+V V D+NDN P F+Q YT ++EDA + SV+TV A D D ++S I Y I GN
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
Query: 3379 QGSSFTIDPVRGE--VKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDN 3436
+ F+I G V + LD + Y L V ASD R +T + ++V+D N +
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
Query: 3437 APVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-G 3495
PVF +Y+V + E++P G +V+ + TDED+ N +F + F ++ G
Sbjct: 709 RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRIDADTG 765
Query: 3496 VLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSS 3555
+ T + + +++ Y L + DNG PQ S TY++I V + + P L
Sbjct: 766 AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL--------- 816
Query: 3556 GEEYSGGV---------IGKIHATDQD------VYDTLTYSLDPQMDNLFSVSSTGGKLI 3600
+ Y G V + +I ATD+D V+ T D D F V ST G +
Sbjct: 817 RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD--FIVESTSGIVR 874
Query: 3601 AHKKLD---IGQYLLNVSVTD 3618
++LD + QY+L D
Sbjct: 875 TLRRLDRENVAQYVLRAYAVD 895
Score = 347 bits (891), Expect = 1e-94
Identities = 289/954 (30%), Positives = 448/954 (46%), Gaps = 58/954 (6%)
Query: 2388 PLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQY---SILSGNDHKHFVIDSAT 2444
P F+ Y+A + E+ P G V ++A D D + +L+Y ++ ++ F +D T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2445 GIITLSNLHRHALKPFYSLNLSVSD-GVFRSSTQVHVTVI--GGNLHSPAFLQNEYEVEL 2501
G +T + K + ++ D G+ R S +T++ N H P F Q EY+ L
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 2502 AENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA---KDRFYINER-GQIFTLEKLDRE 2557
EN + V+ V+ TDGD+ ++ Y ++ + F I+ R G I T +DRE
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE 358
Query: 2558 TPAEKVISVRL--MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSV 2615
++V +D G + V + + DDNDNAPQF +Y V + G V
Sbjct: 359 EVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
Query: 2616 VKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRA 2675
++V ASD D+GSNA + Y+I S + + ++ +G + L + +T VRA
Sbjct: 419 LRVTASDRDKGSNAVVHYSIM--SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
Query: 2676 VDNGSPSKESVV-LVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
D G P +V LV V++L P F + TV E VP+G + ++A +
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH---EMVA 2791
+ ++ D F I+ +G + + LD E +Y F + AR DH + A
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR----DHGTPALTA 592
Query: 2792 SVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQS 2851
S VS+ V D NDN+P F Y + E+ G+ V+ + A D D+ + + Y Q
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITY---QI 647
Query: 2852 QSVEVIESFAINMET--GWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
S F+I ++ G ++ LD++ Y + V ASD + TA + V VT
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ----DTAQIVVNVT 703
Query: 2910 DVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAV 2969
D N P F + Y V+ED P G + ++S TD D+ E N ++TYF+ D + QF +
Sbjct: 704 DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFME--DSIPQFRI 760
Query: 2970 ETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKA---IVEVKVLDANDNSPVCEKT 3026
+ + V + LD E + +Y L ITA D K+ +E+ V D NDN+P +
Sbjct: 761 DA--DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRD 818
Query: 3027 LYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLG--SGAEKFKLNPDTGELKTSTP 3084
Y ++ EDV P ++QISATD D N + YT G G F + +G ++T
Sbjct: 819 SYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR 878
Query: 3085 LDREEQAVYHLLVRATDGGGRFCQA--SIVLTLEDVNDNAPEFSADPYAITVFENTEPGT 3142
LDRE A Y L A D G + + +T+ DVNDN P F D + + V EN+ G
Sbjct: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
Query: 3143 LLTRVQATDADAGLNRKILYSLID-SADGQFSINELSGIIQLEKPLDRELQAVYTLSLKA 3201
+ RV ATD D G N +I+Y +++ + F ++ SG + LD E + Y L ++A
Sbjct: 939 AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
Query: 3202 VDQGLPRRLTATGTVIVSVLDINDNPPV---FE--YREYGATVSEDILVGTEVLQVYAAS 3256
L R TV V +LD NDNPPV FE + Y T G + +V A
Sbjct: 999 TSAPLVSR----ATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHD 1053
Query: 3257 RDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDG 3310
DI + +TYS GNE +++ TG + + LD E ++V +DG
Sbjct: 1054 PDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Score = 332 bits (851), Expect = 5e-90
Identities = 278/1020 (27%), Positives = 461/1020 (45%), Gaps = 99/1020 (9%)
Query: 563 NDNT-PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEA---GNELDFFS 616
N NT P F+ + + T+P + G + ++ AID DE + ++Y ++A FFS
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
Query: 617 LNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEE 676
L+P +G ++ L S H R+TA D +T+ +
Sbjct: 234 LDPVTGAVTTAEELD---RETKSTHVFRVTAQDHGMPRRSALATLTILVT---------- 280
Query: 677 TGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV 736
N H P F ++EN VG V
Sbjct: 281 -------------------------------DTNDHDPVFEQQ-EYKESLRENLEVGYEV 308
Query: 737 IFMNSTDLDTGFNGKLVYAV---SGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNIT 793
+ + +TD D N ++Y + SGG+ F ID +G+++ P+DRE + Y L +
Sbjct: 309 LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
Query: 794 VYDLGIP--QKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDL 851
D G ++ + + V D NDN P+F ++ Y V+V ED + +++V A+D+D
Sbjct: 369 ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428
Query: 852 GPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFS 909
G N V YSI++ F +D+ TG +++ PLD E E++L++ A+D R P
Sbjct: 429 GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGR-PPLSNV 487
Query: 910 TVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDH 969
+ +V V + D+NDN P F+ ++ V E +P G +++ ++A D D G + ++ Y L
Sbjct: 488 SGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
Query: 970 G-EGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNEN 1028
G + F ++ +G + + +LD E+ Y+ V A+D G P +L+++ V V V+DVN+N
Sbjct: 548 GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTP-ALTASASVSVTVLDVNDN 606
Query: 1029 LHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEET 1088
P F+ + EDA VG+ V+TVSA D DA I Y I G+ F I ++
Sbjct: 607 --NPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH--SVITYQITSGNTRNRFSITSQS 662
Query: 1089 --GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYP 1146
G++ + LD + Y L V A+D +I + V D N + P Y
Sbjct: 663 GGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTV 719
Query: 1147 EIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDRE 1206
+ E+ P +VV I A D D+ N ++ Y + PQ F I TG +TT + +LD E
Sbjct: 720 NVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQA-ELDYE 776
Query: 1207 QQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNA 1266
Q + L +T DNG P KS + + + D NDN PQFL+ Y+ + E P
Sbjct: 777 DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS--- 833
Query: 1267 RREPLYHVIATDKDEGPNAEISYSIEDGNE-HGKFFIEPKTGVVSSKR---FSAAGEYDI 1322
+ + ATD+D G N + Y+ + G++ G F +E +G+V + R +Y +
Sbjct: 834 ----VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY-V 888
Query: 1323 LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV 1382
L AVD G P + + + + + P FE+ F V E+ P+ + ++
Sbjct: 889 LRAYAVDKGMPPARTPMEVTVTVLD---VNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
Query: 1383 EPP----GIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI 1438
P + + I GN F +D +G + LD E + Y L ++AT
Sbjct: 946 TDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVS 1005
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKY----EVVIPEDTAPETEILQISAVDQDEKNKLIYTLQ 1494
V ++++D ND+ P + V + P I ++ A D D + L Y+ +
Sbjct: 1006 RATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFE 1065
Query: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
+ L L+ +TG L S LD+ + ++V+V D V A V ++D
Sbjct: 1066 RGNE---LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
Score = 320 bits (820), Expect = 2e-86
Identities = 273/990 (27%), Positives = 447/990 (45%), Gaps = 69/990 (6%)
Query: 1978 KFTQDVYSAVVKENSTEAETLAVITAIGNPINEP--LFYHI-----LNPDRRFKISRTSG 2030
+F Y A V EN +A + AI E L Y + ++ F + +G
Sbjct: 180 QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
Query: 2031 VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVV 2090
+ TT DRE + V + P A + ++V D ND+ PVF Y +
Sbjct: 240 AV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 2091 KVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH-----EHFQIGPLGEISLKKQFELDT 2145
+ + EVG+ + V A D D+ N + Y L E E F+I P + ++ + +D
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV-IRTRGPVDR 357
Query: 2146 LNKE-YLVTVVAKDGGNP----AFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP 2200
E Y +TV A D G + +A V + + N P F + Y ++ E + +P
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 2201 VVHVQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT 2257
V+ V A+ + V YSI G+ QF ++ TG ++V++PLD+E Y L +RA
Sbjct: 418 VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQ 477
Query: 2258 DSLTGAHAEV--FVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPN 2315
D + V V + V DINDN P+F + T+ E+ +G V+ V+A D+D+ N
Sbjct: 478 DGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDN 537
Query: 2316 RGISYQMFGNHSKSHDH-FHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDV 2374
+ Y++ G HD F +++ TG IS+ LD E+ ++ V A D G P L++
Sbjct: 538 ARLEYRLAG---VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 2375 IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND 2434
V+V V D+NDN P F Q Y R++E A G V V A D D+ + + Y I SGN
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV--ITYQITSGNT 652
Query: 2435 HKHFVIDSAT--GIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAF 2492
F I S + G+++L+ + L+ Y L ++ SDG + + Q+ V V N H P F
Sbjct: 653 RNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVF 712
Query: 2493 LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLE 2552
+ Y V + E+ P T V+ + TD D+G +TY + + + R + G + T
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA-DTGAVTTQA 771
Query: 2553 KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKG 2612
+LD E +++ K + +++ D NDNAPQF Y+ ++
Sbjct: 772 ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPF 831
Query: 2613 TSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFF 2672
TSV+++ A+D D G N + Y + + + + + SG++ T L +
Sbjct: 832 TSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI-VESTSGIVRTLRRLDRENVAQYVLR 890
Query: 2673 VRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH--- 2729
AVD G P + + V V +L P F + + V E+ PIG + + A
Sbjct: 891 AYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDE 950
Query: 2730 --SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH 2787
+ ++Y +V+GN P E F +D SG L LD+E Y I A
Sbjct: 951 GTNAQIMYQIVEGNIP-----EVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---- 1001
Query: 2788 EMVASVDVSIQVKDANDNSPVFES-----SPYEAFIVENLPGGSRVIQIRASDADSGTNG 2842
+V+ V +++ D NDN PV + + Y + PGG+ + ++ A D D +
Sbjct: 1002 PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA-IGRVPAHDPD--ISD 1058
Query: 2843 QVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASD--HGEKIQ--L 2898
+ YS ++ + ++ +N TG + + LD+ + + V+ SD H Q L
Sbjct: 1059 SLTYSFERGNELSLV---LLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCAL 1115
Query: 2899 SSTAIVD------VTVTDVNDSPPRFTAEI 2922
T I D +T+ + SP RF + +
Sbjct: 1116 RVTIITDEMLTHSITLRLEDMSPERFLSPL 1145
Score = 315 bits (806), Expect = 9e-85
Identities = 257/873 (29%), Positives = 401/873 (45%), Gaps = 60/873 (6%)
Query: 1134 DNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITS---GNPQGFFSIH 1190
+ APQ P Y + EN P V + A DPD +L Y + + FFS+
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 1191 PKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFY 1250
P TG + TT+ +LDRE + H+ VT D+G P +S +A + + + D ND+ P F Q+ Y
Sbjct: 236 PVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 1251 KIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGK---FFIEPKTG 1307
K L E + E + V ATD D PNA I Y + +G+ F I+P++G
Sbjct: 295 KESLRENLEVGYE-------VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
Query: 1308 VVSSKRFSAAGEYDI--LSIKAVDNGR-PQKSSTTRLHIEWISKPKPSLEPISFEESFFT 1364
V+ ++ E + L+++A D GR P STT ++S + F E +
Sbjct: 348 VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTA--AVFLSVEDDNDNAPQFSEKRYV 405
Query: 1365 FTVME----SDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE 1420
V E PV + + + + I GN F +D TG + V PLD E
Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYE 465
Query: 1421 QKSNYNLTVEATDGTTTILTQ----VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEIL 1476
Y L V A DG L+ V ++V+D ND+ P F ++ ++ + E +L
Sbjct: 466 TTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
Query: 1477 QISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
+ A+D D + +L Y L F ++ TG + + +LD E V ++ V
Sbjct: 526 HVQAIDADAGDNARLEYRLAGVGHDF---PFTINNGTGWISVAAELDREEVDFYSFGVEA 582
Query: 1535 RDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKN 1594
RD P A + V V D ND+ P FT Y R+ E AAVG+ V+ V+A+D+D +
Sbjct: 583 RDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AH 640
Query: 1595 AEVLYSIESGNIGNSFMIDPVLGS--IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITS 1652
+ + Y I SGN N F I G + A LD + +Y L V A+D ++I
Sbjct: 641 SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIV- 699
Query: 1653 VRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTG 1707
+ VT A+ P F S Y+V ++E G+ V +++A + + + Y ++D +
Sbjct: 700 --VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED--SI 755
Query: 1708 DAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLVHLQDENDNAPVF 1765
F I+ +G + TQ LD+E YTL I + + S T + + + D NDNAP F
Sbjct: 756 PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
Query: 1766 MQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIV-EPSVHTYFAIDS 1824
++ Y G + E + VL I A D D N + Y F ++S
Sbjct: 816 LRDSYQGSVYEDVPPFTSVLQ-------ISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
Query: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
++G + T+ LD E + + D G P A VTV V+D+ND PPVF + +
Sbjct: 869 TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP--ARTPMEVTVTVLDVNDNPPVFEQDEF 926
Query: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT--VQNTT 1942
+ + + G+ V V ATD D +Q++Y I EGNI E F +D +G LT V
Sbjct: 927 DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
Query: 1943 QLRSRYELTVRASDGRFAGLTSVKINVKESKES 1975
+ R Y L ++A+ +V + + + ++
Sbjct: 987 EDRPEYVLVIQATSAPLVSRATVHVRLLDRNDN 1019
Score = 303 bits (776), Expect = 3e-81
Identities = 268/984 (27%), Positives = 454/984 (46%), Gaps = 85/984 (8%)
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE---DGNEHGK 1299
PQF Y+ +PE + P+ + A D DEG + Y+++ D +
Sbjct: 179 PQFQPPSYQATVPENQPAGT-------PVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF 231
Query: 1300 FFIEPKTGVVSSKRFSAAGEYD-------ILSIKAVDNGRPQKSSTTRLHIEWISKPKPS 1352
F ++P TG V++ A E D + + A D+G P++S+ L I +
Sbjct: 232 FSLDPVTGAVTT-----AEELDRETKSTHVFRVTAQDHGMPRRSALATLTI--LVTDTND 284
Query: 1353 LEPISFEESFFTFTVMESDPVAHMIGVISVE----PPGIPLWFDI---TGGNYDSHFDVD 1405
+P+ FE+ + ++ E+ V + + + PP + + + +GG+ F++D
Sbjct: 285 HDPV-FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEID 343
Query: 1406 KGTGTIIVAKPLDAEQKSNYNLTVEATD-----GTTTILTQVFIKVIDTNDHRPQFSTSK 1460
+G I P+D E+ +Y LTVEA+D G + VF+ V D ND+ PQFS +
Sbjct: 344 PRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKR 403
Query: 1461 YEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSSRDPLSLKKFRLDPATGSLYTSE 1518
Y V + ED P +L+++A D+D+ + + Y++ S + +F LD TG+L
Sbjct: 404 YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVS 460
Query: 1519 KLDHEAVHQHTLTVMVRDQDVPVKRNFARIV-VNVSDTNDHAPWFTASSYKGRVYESAAV 1577
LD+E ++TL V +D P N + +V V V D ND+AP F ++ ++ V ES +
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
Query: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637
G +VL V A+D D G NA + Y + F I+ G I A ELDR Y V
Sbjct: 521 GYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGV 580
Query: 1638 KATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA---HSQ 1694
+A D G+P ++ SV + V ++ +P FT EY+V L+E ++G+ V V+A +
Sbjct: 581 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH 640
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKA--LDFETLPIYTLIIQGTNMAGLSTNTTVL 1752
S + Y+I GNT + F I SG + A LD++ Y L + ++ T ++
Sbjct: 641 SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT-AQIV 699
Query: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIV 1812
V++ D N + PVF + YT ++E + V ++I A D D NA + Y +
Sbjct: 700 VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTV-------VLISATDEDTGENARITY-FM 751
Query: 1813 EPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
E S+ F ID+ TGA+ T LDYE+ + + D G P+ + + V D+
Sbjct: 752 EDSI-PQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQ--KSDTTYLEILVNDV 808
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGE-KFSMDY 1931
ND P F + Y+ S+ V+ ++ATD DS ++ Y+ G+ G+ F ++
Sbjct: 809 NDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVES 868
Query: 1932 KTGALTVQNTTQLRSRYELTVRA---SDGRFAGLT--SVKINVKESKESHLKFTQDVYSA 1986
+G + + + +RA G T V + V + ++ F QD +
Sbjct: 869 TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
Query: 1987 VVKENSTEAETLAVITAI--GNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDRE 2042
V+ENS +A +TA N + Y I+ N F++ SG L T D E
Sbjct: 929 FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDLDYE 987
Query: 2043 QQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY----YAVVKVDTEVGH 2098
+ + +V++ T V+ V V + D+NDN PV N Y + + G
Sbjct: 988 DRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG 1044
Query: 2099 VIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI---GPLGEISLKKQFELDTLNKEYLVTVV 2155
I V A D D + + Y + +E + GE+ L + + + E +++V+
Sbjct: 1045 AIGRVPAHDPDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALD-NNRPLEAIMSVL 1101
Query: 2156 AKDGGNPAFSAEVIVPITVMNKAM 2179
DG + + +A+ + +T++ M
Sbjct: 1102 VSDGVH-SVTAQCALRVTIITDEM 1124
Score = 253 bits (646), Expect = 3e-66
Identities = 237/880 (26%), Positives = 379/880 (43%), Gaps = 95/880 (10%)
Query: 108 LNREVKDHYTLIVKALEKNT-NVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE K + V A + A + + V DTND P+F Y SL EN +
Sbjct: 247 LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
Query: 167 SIARVSATDADIGTNGEFYY-----SFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEME 221
+ V ATD D N Y S +++F I P SGVI G +D E + Y++
Sbjct: 307 EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---VTLSPSELDRDPAYAIVTV 278
+ A+D+G S+ A + + +E N+ AP + V ++ VT
Sbjct: 367 VEASDQGR---DPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
Query: 279 DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA 338
D D+G+N + SI++G+ QF + ++ + + +D+++ Y L ++A
Sbjct: 424 SDRDKGSNA-VVHYSIMSGNARGQF-----YLDAQTGALDVVSPLDYETTK-EYTLRVRA 476
Query: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA---- 394
+D G PP + ++ V F ++A + E P V+ V+AI A
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
Query: 395 YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKV 449
+ L Y F++N TG IS+ + R++ + V D AS V
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
Query: 450 LVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN---LN 506
V VL N N P FTQ Y +E+ +GT+V+++SAVD D + +TY I + N
Sbjct: 597 SVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRN 654
Query: 507 HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566
G VS + LDY+L R Y L + ASD R+ + + + N +
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKL-ERQYVLAVTASDG----TRQDTAQIVVNVTDANTHR 709
Query: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626
P+F+ + + D G + +SA D D + + + + F ++ ++G ++
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTT 769
Query: 627 KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEK 686
+ L +VS+ +L ITA D
Sbjct: 770 QAEL--DYEDQVSY-TLAITARD------------------------------------- 789
Query: 687 LLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT 746
N + + + + + VN + PQF G V E+ P +SV+ +++TD D+
Sbjct: 790 ----NGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG-SVYEDVPPFTSVLQISATDRDS 844
Query: 747 GFNGKLVYAVSGGNE-DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAW 805
G NG++ Y GG++ D F+++ +G+++ L LDRE +Y L D G+P
Sbjct: 845 GLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTP 904
Query: 806 RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT 865
+ V V+D NDNPP F Q+ + V V E+ + + +V ATD D G N + Y IV
Sbjct: 905 MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN 964
Query: 866 --DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
+ F +D +G + LD E + E+ L I+A L S V V L D NDN
Sbjct: 965 IPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA-----TSAPLVSRATVHVRLLDRNDN 1019
Query: 924 PPTF----IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQS 959
PP I N V R G I + AHDPD+ S
Sbjct: 1020 PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS 1059
Score = 177 bits (449), Expect = 2e-43
Identities = 165/546 (30%), Positives = 250/546 (45%), Gaps = 44/546 (8%)
Query: 106 AILNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAI 164
A L+RE D Y+ V+A + T + A V V VLD ND P F+ Y+V L E+ A+
Sbjct: 566 AELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV 625
Query: 165 RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTS--GVIVLTGRLDYLETKLYEMEI 222
TS+ VSA D D + + + + + F+I S G++ L LDY + Y + +
Sbjct: 626 GTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAV 685
Query: 223 LAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--VTLSPSELDRDPAYAIVTVDD 280
A+D G + A++ V++ AN PV + T++ +E DR +V +
Sbjct: 686 TASD-GTR-------QDTAQIVVNVTDANTHRPVFQSSHYTVNVNE-DRPAGTTVVLISA 736
Query: 281 CDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKD 340
D+ G+ A ++ D + QFR + + G+ V +D++ Y L + A+D
Sbjct: 737 TDED-TGENARITYFMEDSIPQFR-IDADTGA----VTTQAELDYEDQ-VSYTLAITARD 789
Query: 341 KGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLR- 399
G PQ S + + +F +D Y+ + E PP T V+ + A S L
Sbjct: 790 NGI-PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNG 848
Query: 400 ---YVFK-STPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVL 450
Y F+ G F + +G++ L + R+ A + L D+ + +V
Sbjct: 849 RVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT 908
Query: 451 VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP- 509
V VL N NPP F Q + +EN PIG V ++A DPDEG N + Y I N +P
Sbjct: 909 VTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN-IPE 967
Query: 510 -FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPL 568
F +D F+G ++ +LDYE P Y L I+A+ L R V V L + NDN P+
Sbjct: 968 VFQLDIFSGELTALVDLDYEDRPE-YVLVIQATSAPLVSRATVHV----RLLDRNDNPPV 1022
Query: 569 ---FEKI-NCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVL 624
FE + N T G I V A D D + Y E GNEL LN ++G L
Sbjct: 1023 LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGEL 1082
Query: 625 SLKRSL 630
L R+L
Sbjct: 1083 KLSRAL 1088
Score = 153 bits (387), Expect = 3e-36
Identities = 195/769 (25%), Positives = 328/769 (42%), Gaps = 107/769 (13%)
Query: 70 VRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAI-LNREVKDHYTLIVKALEKN-- 126
V Y I+SG++ F +L +T + L+ E YTL V+A +
Sbjct: 434 VHYSIMSGNARGQF-----------YLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
Query: 127 --TNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEF 184
+NV V VQVLD ND P+F T + ++ E+ + + V A DAD G N
Sbjct: 483 PLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
Query: 185 YYSFK--DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAK 242
Y F I+ +G I + LD E Y + A D +G+ +++ A
Sbjct: 541 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD-----HGTPALTASAS 595
Query: 243 LTVHIEQANECAPVITAVTLSPSELDRDPAY--AIVTVDDCDQGANGDIASLSIVAGDLL 300
++V + N+ P T + L+ D A ++VTV D+ A+ + + I +G+
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYT-VRLNEDAAVGTSVVTVSAVDRDAH-SVITYQITSGNTR 653
Query: 301 QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQ-----AKDKGTPPQFSSVKVIHV 355
+F ++ S G GG+ + P Y L Q GT + + V++V
Sbjct: 654 NRF-SITSQSG---------GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQI-VVNV 702
Query: 356 TSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAI--PAYSHLRYVFKSTPGKAKFSL 413
T PV F+ Y ++E P T VV++ A + R + +F +
Sbjct: 703 TDANTHR-PV-FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRI 760
Query: 414 NYNTGLISILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAY 468
+ +TG ++ + + + L +T D +K+ T L + V N N P+F + +Y
Sbjct: 761 DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
Query: 469 KAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI--ANLNHVPFAIDHFTGAVSTSENLD 526
+ + E+VP T+V+ +SA D D G NG V Y+ + F ++ +G V T LD
Sbjct: 821 QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLD 880
Query: 527 YELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGE 586
E + + Y LR A D G+P R + T+T+ ++NDN P+FE+ + + + +G
Sbjct: 881 RENVAQ-YVLRAYAVDKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
Query: 587 QITTVSAIDADE--LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
+ V+A D DE + YQI GN + F L+ SG L+ +L+D
Sbjct: 939 AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVD------------ 983
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFF 704
D E+ P Y+ + A S LV+ A + L + + G E +F
Sbjct: 984 ---LDYED--RPEYVLVIQATSAPLVSR-------ATVHVRLLDRNDNPPVLGNFEILF- 1030
Query: 705 DSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC 764
N ++ S+ P G ++ + + D D + L Y+ GNE S
Sbjct: 1031 -----NNYVTNRSSSFP-----------GGAIGRVPAHDPD--ISDSLTYSFERGNELSL 1072
Query: 765 FMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV 813
+++ TG LK+ LD + +++ V D G+ A L V ++
Sbjct: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
Score = 104 bits (260), Expect = 2e-21
Identities = 126/508 (24%), Positives = 207/508 (40%), Gaps = 43/508 (8%)
Query: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
FT EY V + E++A T V V + + Y+I SG++ N F G
Sbjct: 610 FTQPEYTVRLNEDAAVGTSV---VTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153
L + L+ +++ Y L V A + A+ + V V D N RP+F +
Sbjct: 667 VSLALP--------LDYKLERQYVLAVTASDGTRQDTAQ--IVVNVTDANTHRPVFQSSH 716
Query: 154 YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYL 213
Y+V++ E+ T++ +SATD D G N Y +D F I +G + LDY
Sbjct: 717 YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE 776
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAY 273
+ Y + I A D G+ S L + + N+ AP + S + P +
Sbjct: 777 DQVSYTLAITARDNGIPQK-----SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPF 831
Query: 274 AIV---TVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF 330
V + D D G NG + + GD V S G V+ + +D + +
Sbjct: 832 TSVLQISATDRDSGLNGRV-FYTFQGGDDGDGDFIVESTSGI----VRTLRRLDRE-NVA 885
Query: 331 GYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVK 390
Y L A DKG PP + ++V VT P FE+D + + E +P V V
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVT-VTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVT 944
Query: 391 AI--PAYSHLRYVFKSTPGKAK--FSLNYNTGLISILEPVKRQQAAHFEL--EVTTSDRK 444
A ++ + +++ G F L+ +G ++ L + + + L + T++
Sbjct: 945 ATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLV 1004
Query: 445 ASTKVLVKVLGANSNPP-----EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVT 499
+ V V++L N NPP E Y + P G + + A DPD ++ +T
Sbjct: 1005 SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDS--LT 1061
Query: 500 YSIANLNHVPFA-IDHFTGAVSTSENLD 526
YS N + ++ TG + S LD
Sbjct: 1062 YSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 86.7 bits (213), Expect = 5e-16
Identities = 105/437 (24%), Positives = 158/437 (36%), Gaps = 88/437 (20%)
Query: 3770 VTPRHHRAAVCLCKEGR---CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQC 3826
V RH A + G CP + C+ + C G CV+ W+ +C CP G G+
Sbjct: 1551 VDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQ-WDA-FSCECPLGFGGKS 1608
Query: 3827 PG---SSSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAVVMYA--RGTDYSILEI 3881
++ G+S V + L++ RT V++ A RG L++
Sbjct: 1609 CAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQL 1668
Query: 3882 HHGRLQYKFD-CGSGPGIVSVQSIQVNDGQWH--AVALEVNGNYARLVLDQVH---TASG 3935
G + + G + ++ + NDG WH +AL +G +L + A G
Sbjct: 1669 REGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEG 1728
Query: 3936 TAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRS 3995
L L+L N G G + V GFRGC+ + ++ +NS S
Sbjct: 1729 NLGPRLHGLHLSNITV--------GGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPS 1780
Query: 3996 YAHIEESVDVSPGCFL---------------------------------TATEDCASNPC 4022
+ ES++V GC L T C NPC
Sbjct: 1781 HG---ESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPC 1837
Query: 4023 QNGGVCN--PSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYG-------GTCVVD-NG 4072
++ VC PS GY C+C Y+G +CE ++ +PC G G C D +
Sbjct: 1838 EHQSVCTRKPSAPHGYTCECPPNYLGPYCETRID----QPCPRGWWGHPTCGPCNCDVSK 1893
Query: 4073 GFVCQCRGLYTGQRCQLSPY----------CKDEPCKNGGTCFDSLDGAVCQCDSGFRG- 4121
GF C C+ + Y C P + D DG C C G G
Sbjct: 1894 GFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQ-CPCKPGVIGR 1952
Query: 4122 --ERCQSDIDECSGNPC 4136
+RC + E + N C
Sbjct: 1953 QCDRCDNPFAEVTTNGC 1969
Score = 82.4 bits (202), Expect = 9e-15
Identities = 42/99 (42%), Positives = 52/99 (52%), Gaps = 5/99 (5%)
Query: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSP 4091
P GG C+C + G +CE V+ C S+PC G C GG+ C CR YTG+ C++S
Sbjct: 1268 PVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSA 1327
Query: 4092 ---YCKDEPCKNGGTCFDSLDGAV-CQCDSG-FRGERCQ 4125
C CKNGGTC + L G C C SG F CQ
Sbjct: 1328 RSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ 1366
Score = 59.7 bits (143), Expect = 7e-08
Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 22/96 (22%)
Query: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130
C EPC+N C FDS + G C+C GF G+ C++++D
Sbjct: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
Query: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAA 4166
C PC C + G Y C C Y G HCE +A
Sbjct: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSA 1327
Score = 58.5 bits (140), Expect = 1e-07
Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 4085 QRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCEN 4144
Q C L C PC C + D C CD G+ G+ C + C NPC H ++C
Sbjct: 1789 QGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC---TNVCDLNPCEHQSVCTR 1845
Query: 4145 ----THGSYHCNCSHEYRGRHCE 4163
HG Y C C Y G +CE
Sbjct: 1846 KPSAPHG-YTCECPPNYLGPYCE 1867
Score = 56.2 bits (134), Expect = 7e-07
Identities = 34/83 (40%), Positives = 41/83 (49%), Gaps = 5/83 (6%)
Query: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP--CSSKPCLYGGTCV- 4068
T + C S PC G C S GGY C C Y G HCE+S C+ C GGTCV
Sbjct: 1287 TEVDLCYSRPCGPHGRCR-SREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVN 1345
Query: 4069 VDNGGFVCQC-RGLYTGQRCQLS 4090
+ GGF C C G + CQ++
Sbjct: 1346 LLVGGFKCDCPSGDFEKPYCQVT 1368
Score = 39.7 bits (91), Expect = 0.070
Identities = 61/291 (20%), Positives = 102/291 (35%), Gaps = 68/291 (23%)
Query: 4124 CQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHC--EDAAPNQY----------- 4170
C + + C N C +G C N ++ C C + G+ C E A P +
Sbjct: 1571 CPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGL 1630
Query: 4171 ---VSTPWNIGL------AEGIGIVVFVAGIFLLVVVFVLCRKMIS-----------RKK 4210
+S PW + L A+G+ + G + + M+S R +
Sbjct: 1631 SLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLE 1690
Query: 4211 KHQAEPKDKHL---------GPATAFLQRPYFDSKLNKNIYSDIPP-QVPVRPISYTPSI 4260
+A D H GP A L Y + N+ + + + P
Sbjct: 1691 PGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPG- 1749
Query: 4261 PSDSRNNLDRNSFEGSAIPEHPE-FSTFNPESVHGHRKAVAV---CSVAPNLPPPPPSNS 4316
P+ R +G + + PE ++ +P H +++ V CS+ P P ++
Sbjct: 1750 PAGGVARGFRGCLQGVRVSDTPEGVNSLDP----SHGESINVEQGCSL-----PDPCDSN 1800
Query: 4317 PSDSDSIQKPSWDF-----------DYDTKVVDLDPCLSKKPLEEKPSQPY 4356
P ++S WD D T V DL+PC + KPS P+
Sbjct: 1801 PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPH 1851
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 473 bits (1217), Expect = e-132
Identities = 407/1482 (27%), Positives = 664/1482 (44%), Gaps = 172/1482 (11%)
Query: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLYSLVKGNTPESNRDESFVIDR 2755
P+F + Y V E+ GT + + A+ +G ++YSL S E F ID
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAA--LMNSRSLELFSIDP 380
Query: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDH---EMVASVDVSIQVKDANDNSPVFESS 2812
QSG ++ +LD E+ + + R T DH + A+ V++ V D ND+SPVFE +
Sbjct: 381 QSGLIRTAAALDRESMERHYL----RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQA 436
Query: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL--DQSQSVEVIESFAINMETGWIT 2870
Y + EN+ G ++Q+RA+D D+ N + Y + +F I+ +G I+
Sbjct: 437 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIS 496
Query: 2871 TLKELDHEKRDNYQIKVVASDHGEKI-QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSE 2929
T +D E ++Y++ V ASD G++ S+T V +TV D ND+ P+F+ + Y V E
Sbjct: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
Query: 2930 DDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKR 2989
D V+ ++ TD D ++ N V Y I G+ G FA++++ E + V PLD E
Sbjct: 557 DVRPHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGE--IQVVAPLDFEAE 613
Query: 2990 DNYLLTITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
Y L I A D ++ + ++V+D ND+ P+ T + ++ E+ G ++ I
Sbjct: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Query: 3046 SATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG 3104
A DAD NA + Y+L G + F +N TG + S PLDRE Y V A D G
Sbjct: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
Query: 3105 R--FCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILY 3162
AS+ +T+ DVNDN PEF+ Y + + E+ GT + V A D DA N I Y
Sbjct: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISY 791
Query: 3163 SLID-SADGQFSINELSGI--IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVS 3219
+ + +F+I+ G+ + L PLD + + + L L A D+ L V ++
Sbjct: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY----VHIN 847
Query: 3220 VLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFS 3279
+ D N + PVF+ Y +V+ED +G+ ++ + A+ D+ NA ITY + + +F
Sbjct: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFR 905
Query: 3280 IDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDT 3339
ID+ +GA+ + LDYE Y L + A D G P +D V V V D+NDN P F
Sbjct: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 3340 YTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDPVRGEVKVTKLL 3398
YT ++SEDA SV+ + A D D +N + Y+ +G G FTI+P G V+ + L
Sbjct: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
Query: 3399 DRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFS 3458
DRE +S Y LT A D G PP ++ + V DVNDNAPVF + V ++EN VG
Sbjct: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
Query: 3459 VLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKV 3517
V Q+ D D N + IV GN + F+++ G L + + + Y++ V+
Sbjct: 1086 VAQITAVDPDEGPNAH-IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
Query: 3518 ADNGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSGGVIGKIHATDQD 3573
P +S T + +R+++++ P + +I ++++ + + G+IG+I A D D
Sbjct: 1145 TS--APLVSRAT-VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
Query: 3574 VYDTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIGQYLLN---VSVTDGKFTTVADITV 3629
V D L YS + + L V+ T G+L +KLD + L+ V+VTDG + A +
Sbjct: 1202 VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVL 1261
Query: 3630 HIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEP- 3688
+ +T+E+L +++ +R N+ E F+ F + +L D+ I ++Q+
Sbjct: 1262 RVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDV 1321
Query: 3689 -HPHLDVLLFVEKPGSA-------QISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAG 3740
L+V P A S+++L ++ + + +L +C
Sbjct: 1322 GGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLR 1381
Query: 3741 LDCP-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHG------ 3793
C + C + D S S + L P A + RCPP G
Sbjct: 1382 EPCENYMKCVSVLRFDSSAPFLASASTL--FRPIQPIAGL----RCRCPPGFTGDFCETE 1435
Query: 3794 ---CEDDPCPEGSECVSDPWEEKHTCVC-------------------------------- 3818
C +PC G C E +TCVC
Sbjct: 1436 LDLCYSNPCRNGGACARR--EGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDA 1493
Query: 3819 PSGRFG-QCPGS----------SSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAV 3867
P+G F QCP ++ + +S+V +R + + L++ T +
Sbjct: 1494 PNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFR--GLRQRFHLTLSLSFATVQQSGL 1551
Query: 3868 VMY----ARGTDYSILEIHHGRLQYKFDCGSGPGIVS-VQSIQVNDGQWHAVALEVNGNY 3922
+ Y D+ LE+ G+++ + G +VS ++DGQWH V L Y
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRY---Y 1608
Query: 3923 ARLVLDQVHTASGTAPGTLKTLNLDN-----YVFFGGHIRQQG-------TRHGRS---- 3966
+ D + A G + + L++D+ + FG I T +S
Sbjct: 1609 NKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLT 1668
Query: 3967 ---------------PQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFL 4011
P F GCM ++++G+ + + A + GC
Sbjct: 1669 GPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDM-------AAFVANNGTMAGC-Q 1720
Query: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISV 4053
C S PC+N G C+ G + C C + G C++++
Sbjct: 1721 AKLHFCDSGPCKNSGFCS-ERWGSFSCDCPVGFGGKDCQLTM 1761
Score = 392 bits (1007), Expect = e-108
Identities = 278/858 (32%), Positives = 427/858 (49%), Gaps = 36/858 (4%)
Query: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFA 2861
A + P F Y+ + EN G+ V+++ A D D+G G+++YSL + +E F+
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 2862 INMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAE 2921
I+ ++G I T LD E + + ++V A DHG +LS+T +V VTV D ND P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQA 436
Query: 2922 IYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG---GDPLGQFAVETIQNEWKV 2978
Y+ T+ E+ +G I L TD D+ N + Y G A E +
Sbjct: 437 QYRETLRENVEEGYPILQLRATDGDAPP-NANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 2979 YVKKPLDREKRDNYLLTITATD-----GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIP 3033
+DRE ++Y L + A+D G S+ V + VLD NDN+P + Y +
Sbjct: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
Query: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAV 3092
EDV P ++++++ATD D +N + Y ++ G+ F ++ TGE++ PLD E +
Sbjct: 556 EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
Query: 3093 YHLLVRATDGGGRFCQASIVLT---LEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
Y L +RA D G + L + D+ND+ P F + P+ ++V EN G + +QA
Sbjct: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 3150 TDADAGLNRKILYSLIDSA-DGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208
DAD G N ++ YSL A D F IN +G + + PLDRE Y ++A D G P
Sbjct: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP- 734
Query: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYS 3268
L+A+ +V V+VLD+NDN P F +EY ++ED VGT V+ V A RD AN+ I+Y
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 3269 IISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVT 3326
I GN +F+I ++ G V + LDY+ + L + A+D +L D V++N+T
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINIT 849
Query: 3327 DINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTID 3386
D N + PVF Y+ ++ED + +++ + A D D N+ I Y + D F ID
Sbjct: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL--PQFRID 907
Query: 3387 PVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYS 3446
G + + LD E YTL + A DNG P + +TT V + V+DVNDNAP F +Y+
Sbjct: 908 ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
Query: 3447 VIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND-EKAFEVNP-QGVLLTSSAIK 3504
++ E+ P SVLQ+ TD D+ NG +T G D + F + P G++ T +
Sbjct: 968 GLVSEDAPPFTSVLQISATDRDAHANG-RVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
Query: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
R+ Y L D G P L + I + V + + P E + G V+
Sbjct: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 3565 GKIHATDQDVYDT--LTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI---GQYLLNVSVTD 3618
+I A D D + Y + + + LF + G+L A LD +Y++ V T
Sbjct: 1087 AQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
Query: 3619 GKFTTVADITVHIRQVTQ 3636
V+ TVH+R V Q
Sbjct: 1147 APL--VSRATVHVRLVDQ 1162
Score = 388 bits (997), Expect = e-107
Identities = 273/873 (31%), Positives = 432/873 (49%), Gaps = 60/873 (6%)
Query: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL----DHGEGNFDVDKLS 980
P F NY+ V E+ GT ++ + A DPD G++G++ YSL F +D S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 981 GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
G +R LD E + + L V A+D G P LS+T V V V D N+ H PVF +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRND--HSPVFEQAQYR 439
Query: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI-----RDGSGVGVFKIGEETGVIETSD 1095
T++E+ G ++ + A D DA + +RY + F+I +G+I TS
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
Query: 1096 RLDRESTSHYWLTVFATDQGVV--PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSP 1153
R+DRE Y L V A+DQG P S+ + ++I V D NDNAPQ SE Y ++ E+
Sbjct: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
Query: 1154 KDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHIL 1213
V+++ A D D +N + Y I SGN +G F+I TG I + LD E + E+ L
Sbjct: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA-PLDFEAEREYAL 618
Query: 1214 EVTVTDNGSPPKS-TIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLY 1272
+ D G PP S ++++D ND+ P F+ +++ + E +
Sbjct: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS-------VI 671
Query: 1273 HVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG--VVSSKRFSAAGEYDILSIKAVDN 1330
H+ A D D G NA + YS+ F I TG VS + E+ ++A D+
Sbjct: 672 HIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
Query: 1331 GRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVME-----SDPVAHMIGVISV--- 1382
G P S++ + ++ + ++ FT+ E ++ A V+SV
Sbjct: 732 GSPPLSASASV----------TVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 1383 -EPPGIPLWFDITGGNYDSHFDVDK--GTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL 1439
+ + ITGGN + F + G G + +A PLD +Q+ + L + A+D
Sbjct: 782 DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSR 1497
V I + D N HRP F ++ Y V + ED + I+ ISA D D E ++ Y L+
Sbjct: 842 CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED-- 899
Query: 1498 DPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTND 1557
+L +FR+D +G++ LD+E +TL + RD +P K + + V V+D ND
Sbjct: 900 ---NLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
Query: 1558 HAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMIDPVL 1616
+AP F AS Y G V E A + VLQ++A D+D N V Y+ ++G G+ F I+P
Sbjct: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS 1016
Query: 1617 GSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVEL 1676
G ++T + LDR + Y+L A D+G PP+ S+++ V ++ +P F ++E+ V +
Sbjct: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRV 1076
Query: 1677 SETVSIGSFVGMVTA-----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP 1731
E +GS V +TA + ++Y+I +GN + F ++ SG + LD+E
Sbjct: 1077 KENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQ 1136
Query: 1732 IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPV 1764
Y +++Q T+ A L + TV V L D+NDN+PV
Sbjct: 1137 EYVIVVQATS-APLVSRATVHVRLVDQNDNSPV 1168
Score = 376 bits (965), Expect = e-103
Identities = 283/947 (29%), Positives = 467/947 (49%), Gaps = 61/947 (6%)
Query: 726 VKENQPVGSSVIFMNSTDLDTGFNGKLVY---AVSGGNEDSCFMIDMETGMLKILSPLDR 782
V EN+ G++V+ + + D D G G+LVY A+ F ID ++G+++ + LDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 783 ETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII 842
E+ +++ L +T D G P+ +A ++ V V D ND+ P F Q Y + E+ E I+
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
Query: 843 QVEATDKDLGPNGHVTYSIV-------TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKI 895
Q+ ATD D PN ++ Y V F ID +G+++ + +DRE + L +
Sbjct: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVV 513
Query: 896 EARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPD 955
EA DQ +E +TV V +++ D NDN P F Y +VRED+ TV++ + A D D
Sbjct: 514 EASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD 573
Query: 956 LGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014
+G V Y+++ + G+F +D L+G +++V LDFE ++ Y L +RA+D G+P ++
Sbjct: 574 KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNN 633
Query: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
T ++VVD+N+ H P+F S + +V E+AP+G V+ + A D D + + YS+
Sbjct: 634 TGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 1075 DGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVND 1134
+ F I TG + S LDRES HY+ V A D G PLS+ + + V DVND
Sbjct: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
Query: 1135 NAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG 1194
N P+ + Y+ + E++ SVV + A D D +N + Y+IT GN + F+I + G
Sbjct: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
Query: 1195 L-ITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIR 1253
+ + T + LD +Q+ L +T +D V + I D N ++P F Y +
Sbjct: 810 VGLVTLALPLDYKQERYFKLVLTASDRALHDH---CYVHINITDANTHRPVFQSAHYSVS 866
Query: 1254 LPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR 1313
+ E DR + + + A+D D G NA I+Y +ED +F I+ +G ++
Sbjct: 867 VNE----DRPMGS---TIVVISASDDDVGENARITYLLEDNLP--QFRIDADSGAIT--- 914
Query: 1314 FSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVM 1368
A +Y+ L+I A DNG PQK+ TT ++E + P F S +T V
Sbjct: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAP-QFVASHYTGLVS 971
Query: 1369 ESDPVAHMIGVIS-----VEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
E P + IS G + G + D F ++ +G + + LD E S
Sbjct: 972 EDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVS 1031
Query: 1424 NYNLTVEATD-GTTTILTQVFIKVI--DTNDHRPQFSTSKYEVVIPEDTAPETEILQISA 1480
Y LT A D G + T V I+V+ D ND+ P F ++EV + E++ + + QI+A
Sbjct: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
Query: 1481 VDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD 1538
VD DE ++Y + P + F++D +G L LD+EA ++ + V
Sbjct: 1092 VDPDEGPNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAP 1148
Query: 1539 VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYES----AAVGSVVLQVTALDKDKGKN 1594
+ + A + V + D ND++P Y S ++ ++ A D D +
Sbjct: 1149 LVSR---ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH 1205
Query: 1595 AEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATD 1641
+ YS E GN +++ G ++ +++LD + ++V TD
Sbjct: 1206 --LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
Score = 375 bits (964), Expect = e-103
Identities = 298/948 (31%), Positives = 440/948 (46%), Gaps = 101/948 (10%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQ 465
FS++ +GLI + R+ L VT D A+T V V V N + P F Q
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 466 TAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN------LNHVPFAIDHFTGAV 519
Y+ ENV G ++ L A D D N + Y F ID +G +
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 520 STSENLDYELMPRVYTLRIRASDWGL-PYRREVEVLATITLNNLNDNTPLFEKINCEGTI 578
STS +D E M Y L + ASD G P R V IT+ + NDN P F + +
Sbjct: 496 STSGRVDREHMES-YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
Query: 579 PRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGA 636
D+ + V+A D D+ LV Y I +GN F+++ +G + + L
Sbjct: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
Query: 637 KVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQ 696
+ ++LRI A D P N T AS ++V+
Sbjct: 615 E---YALRIRAQDA---GRPPLSNNTGLASIQVVD------------------------- 643
Query: 697 GEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAV 756
+N HIP F ST P + V EN P+G SVI + + D D G N +L Y++
Sbjct: 644 ------------INDHIPIFVST-PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
Query: 757 SGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+G D+ F+I+ TG + + PLDRE+ + Y + D G P +A + V V+D N
Sbjct: 691 TGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVT 874
DN PEF + Y + ++ED V + ++ V A D+D N ++Y I + F+I +
Sbjct: 751 DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQG 808
Query: 875 GV--VNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNY 932
GV V +A PLD + + L + A D+A L V +++ D N + P F +Y
Sbjct: 809 GVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPVFQSAHY 863
Query: 933 RVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFE 992
V V ED P G+ I+ + A D D+G++ ++ Y LL+ F +D SGA+ + LD+E
Sbjct: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYE 922
Query: 993 KKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSL 1052
+ Y L + A+D G P + T YVEV V DVN+N P F + G V EDAP +
Sbjct: 923 DQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDN--APQFVASHYTGLVSEDAPPFTS 979
Query: 1053 VMTVSAHDEDARRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFA 1111
V+ +SA D DA +G ++Y+ ++G G G F I +G++ T RLDRE+ S Y LT +A
Sbjct: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
Query: 1112 TDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSN 1171
D+GV PL + + I + V+DVNDNAP + + ENS V QI A DPD N
Sbjct: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
Query: 1172 DKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARV 1231
+MY+I GN F + +G +T LD E + E+++ V T S P + A V
Sbjct: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALI-DLDYEARQEYVIVVQAT---SAPLVSRATV 1155
Query: 1232 IVKILDENDNKPQF--LQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISY 1289
V+++D+NDN P Q + + R R P Y D + + Y
Sbjct: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAY-------DPDVSDHLFY 1208
Query: 1290 SIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSS 1337
S E GNE + +G + R +DN RP +S
Sbjct: 1209 SFERGNELQLLVVNQTSGELRLSR-------------KLDNNRPLVAS 1243
Score = 353 bits (905), Expect = 3e-96
Identities = 292/1029 (28%), Positives = 472/1029 (45%), Gaps = 93/1029 (9%)
Query: 443 RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
RK ++ + A + P+F Q Y+ EN GT V+ + A DPD GE G + YS+
Sbjct: 305 RKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL 364
Query: 503 ANLNHVP----FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT 558
A L + F+ID +G + T+ LD E M R Y LR+ A D G P R + +T
Sbjct: 365 AALMNSRSLELFSIDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVT 422
Query: 559 LNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD-------ELQLVQYQIEAGNE 611
+ + ND++P+FE+ T+ ++ G I + A D D + V
Sbjct: 423 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 482
Query: 612 LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVN 671
F ++P SG++S S R+ E++ + V AS
Sbjct: 483 AAAFEIDPRSGLIST---------------SGRVDREHMESY------ELVVEASD---- 517
Query: 672 LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP 731
Q +E G + N + PQF QV+E+
Sbjct: 518 -QGQEPGPRSATVR----------------VHITVLDENDNAPQFSEKRYVA-QVREDVR 559
Query: 732 VGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLN 791
+ V+ + +TD D NG + Y + GN F ID TG +++++PLD E +Y L
Sbjct: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALR 619
Query: 792 ITVYDLGIPQKA-AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD 850
I D G P + L + VVD ND+ P F+ + V V E+ + +I ++A D D
Sbjct: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 851 LGPNGHVTYSI--VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLF 908
G N + YS+ V F I+S TG V+++ PLDRE + +EARD P L
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG--SPPLS 737
Query: 909 STVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLD 968
++ V V++ DVNDN P F Y +++ ED GT ++ + A D D + + Y +
Sbjct: 738 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA--ISYQITG 795
Query: 969 HGEGNFDVDKLSGAVRIVQ---QLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
N G V +V LD+++++ + L + A D+ +L CYV + + D
Sbjct: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDA 851
Query: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIG 1085
N H PVF S +V ED P+GS ++ +SA D+D + I Y + D + F+I
Sbjct: 852 --NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRID 907
Query: 1086 EETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYY 1145
++G I LD E Y L + A D G+ + + + V DVNDNAPQ Y
Sbjct: 908 ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
Query: 1146 PEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG-NPQGFFSIHPKTGLITTTSRKLD 1204
+ E++P SV+QI A D D+ +N ++ Y +G + G F+I P +G++ T R+LD
Sbjct: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV-RRLD 1026
Query: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRER 1264
RE + L D G PP T + V + D NDN P F + +++R+ +E
Sbjct: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRV-------KEN 1079
Query: 1265 NARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSS---KRFSAAGEYD 1321
+ + + A D DEGPNA I Y I +GN F ++ +G +++ + A EY
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY- 1138
Query: 1322 ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVI 1380
++ ++A P S T +H+ + + S +F+ F + SD + +IG I
Sbjct: 1139 VIVVQA--TSAPLVSRAT-VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRI 1195
Query: 1381 SVEPPGIP--LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI 1438
P + L++ GN V++ +G + +++ LD + ++ V TDG ++
Sbjct: 1196 PAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSV 1255
Query: 1439 LTQVFIKVI 1447
Q ++V+
Sbjct: 1256 TAQCVLRVV 1264
Score = 345 bits (885), Expect = 6e-94
Identities = 283/971 (29%), Positives = 459/971 (47%), Gaps = 64/971 (6%)
Query: 2079 PVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL-----KEHHEHFQIGPL- 2132
P F Y +V + G + V A D D+G G + Y L E F I P
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 2133 GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAE 2190
G I + +++ + YL V A+D G+P SA +V +TV N PVFE+ Y
Sbjct: 383 GLIRTAAALDRESMERHYL-RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
Query: 2191 IAESIQVHSPVVHVQA---NSPEGLKVFYSITDGDPFSQ------FTINFNTGVINVIAP 2241
+ E+++ P++ ++A ++P + Y G P ++ F I+ +G+I+
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFV-GPPAARAAAAAAFEIDPRSGLISTSGR 500
Query: 2242 LDFEAHPAYKLSIRATDSLTGA---HAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298
+D E +Y+L + A+D A V V I V D NDN P F+++ Y + E
Sbjct: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560
Query: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTI 2358
T V++V ATD D + N + Y + +S+ H F +DS TG I ++ LD+E R++ +
Sbjct: 561 HTVVLRVTATDRDKDANGLVHYNIISGNSRGH--FAIDSLTGEIQVVAPLDFEAEREYAL 618
Query: 2359 FVRAVDGGMPTLSSDV-IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDA 2417
+RA D G P LS++ + ++ V D+ND+ P+F ++ + E+AP GH V ++A DA
Sbjct: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
Query: 2418 DSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN-LHRHALKPFYSLNLSVSDGV--FRS 2474
D + +L+YS+ FVI+SATG +++S L R +++ ++ + G +
Sbjct: 679 DHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSA 738
Query: 2475 STQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVND 2534
S V VTV+ N + P F EY + L E+A + T V+ V D D+ ++Y I
Sbjct: 739 SASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQITGG 796
Query: 2535 FAKDRFYINERGQIFTLE-KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNA 2593
++RF I+ +G + + L + E+ + L A D C V++ +TD N +
Sbjct: 797 NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH-DHCYVHINITDANTHR 855
Query: 2594 PQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSG 2653
P F++ Y V++ G+++V + ASD D G NA ITY +E + + I+ SG
Sbjct: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFR----IDADSG 911
Query: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713
IT + L + +T + A DNG P K V V + P+F YT VS
Sbjct: 912 AITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVS 971
Query: 2714 EDVPIGTEIDLIR-----AEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDH 2768
ED P T + I A +G V Y+ G + D F I+ SG ++ + LD
Sbjct: 972 EDAPPFTSVLQISATDRDAHANGRVQYTFQNG----EDGDGDFTIEPTSGIVRTVRRLDR 1027
Query: 2769 ETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRV 2828
E Y+ + A + + V + + V+D NDN+PVF + +E + EN GS V
Sbjct: 1028 EAVSVYELTAYA-VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 2829 IQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVV 2888
QI A D D G N +MY + + + E F +++ +G +T L +LD+E R Y I V
Sbjct: 1087 AQITAVDPDEGPNAHIMYQIVEG---NIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
Query: 2889 ASDHGEKIQLSSTAIVDVTVTDVNDSPP-----RFTAEIYKGTVSEDDPQGGVIAILSTT 2943
A+ L S A V V + D ND+ P + Y S+ P G I+
Sbjct: 1144 AT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG----IIGRI 1195
Query: 2944 DADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTF 3003
A +++ + Y G+ L V Q ++ + + LD + + +T TDG
Sbjct: 1196 PAYDPDVSDHLFYSFERGNELQLLVVN--QTSGELRLSRKLDNNRPLVASMLVTVTDGLH 1253
Query: 3004 SSKAIVEVKVL 3014
S A ++V+
Sbjct: 1254 SVTAQCVLRVV 1264
Score = 338 bits (868), Expect = 6e-92
Identities = 279/969 (28%), Positives = 447/969 (46%), Gaps = 57/969 (5%)
Query: 1451 DHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLD 1508
+ PQF Y+ ++PE+ A T +L++ A D D E +L+Y+L + + SL+ F +D
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 1509 PATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK 1568
P +G + T+ LD E++ +H L V +D P + V V+D NDH+P F + Y+
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
Query: 1569 GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI-----ESGNIGNSFMIDPVLGSIKTAK 1623
+ E+ G +LQ+ A D D NA + Y +F IDP G I T+
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
Query: 1624 ELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD--NASPKFTSKEYSVELSETVS 1681
+DR + Y+L+V+A+D+G P +VR+ +T+ D + +P+F+ K Y ++ E V
Sbjct: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
Query: 1682 IGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLI 1736
+ V VTA + V Y I GN+ F I+ +G I LDFE Y L
Sbjct: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALR 619
Query: 1737 I--QGTNMAGLSTNTTVL-VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLV 1793
I Q LS NT + + + D ND+ P+F+ + + E+A + V+
Sbjct: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH------- 672
Query: 1794 IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMG 1853
I+A DAD NA L Y + + T F I+S+TG + LD E + F V+ D G
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
Query: 1854 TPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQ 1913
+P L A +A+VTV V+D+ND P F Y L G V++V A D D++ S
Sbjct: 733 SPPLSA--SASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SA 788
Query: 1914 LIYSITEGNIGEKFSMDYKTGALTVQNTTQL---RSRY-ELTVRASDGRFAGLTSVKINV 1969
+ Y IT GN +F++ + G V L + RY +L + ASD V IN+
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI 848
Query: 1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDR--RFKISR 2027
++ F YS V E+ T+ VI+A + + E L D +F+I
Sbjct: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
Query: 2028 TSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYY 2087
SG + T P D E Q + + + + P V+V+V D NDNAP FV Y
Sbjct: 909 DSGAI-TLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
Query: 2088 AVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE---HFQIGPL-GEISLKKQFEL 2143
+V D + ++A DRD+ NG V Y + + F I P G + ++ +
Sbjct: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDR 1027
Query: 2144 DTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPV 2201
+ ++ Y +T A D G P V + + V +N PVF + + E+ V S V
Sbjct: 1028 EAVS-VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 2202 VHVQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATD 2258
+ A P+ + Y I +G+ F ++ +G + + LD+EA Y + ++AT
Sbjct: 1087 AQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
Query: 2259 SLTGAHAEVFVDIIVDDINDNPPVFAQ-----QSYAVTLSEASVIGTSVVQVRATDSDSE 2313
+ + A V V ++ D NDN PV +Y S+ G + ++ A D D
Sbjct: 1147 APLVSRATVHVRLV--DQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDPDVS 1203
Query: 2314 PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSD 2373
+ S++ GN + V+ ++G + L R LD + ++ V DG +
Sbjct: 1204 DHLFYSFER-GNELQL---LVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQC 1259
Query: 2374 VIVTVDVTD 2382
V+ V +T+
Sbjct: 1260 VLRVVIITE 1268
Score = 326 bits (835), Expect = 4e-88
Identities = 289/1025 (28%), Positives = 465/1025 (45%), Gaps = 103/1025 (10%)
Query: 544 GLPYRREVEVLATIT---LNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--E 598
GLP R E + + + P F + N + +P + G + V A D D E
Sbjct: 297 GLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGE 356
Query: 599 LQLVQYQIEA---GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
+ Y + A L+ FS++P SG++ +L + H LR+TA D
Sbjct: 357 AGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALD---RESMERHYLRVTAQD------ 407
Query: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
H L T VA +A++ + HS Q
Sbjct: 408 -----------HGSPRLSA-TTMVAVTVADR------------------NDHSPVFEQAQ 437
Query: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSG-----GNEDSCFMIDME 770
+R TL +EN G ++ + +TD D N L Y G + F ID
Sbjct: 438 YRETL------RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPR 491
Query: 771 TGMLKILSPLDRETTDKYTLNITVYDLGI---PQKAAWRLLHVVVVDANDNPPEFLQESY 827
+G++ +DRE + Y L + D G P+ A R +H+ V+D NDN P+F ++ Y
Sbjct: 492 SGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVR-VHITVLDENDNAPQFSEKRY 550
Query: 828 FVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSVTGVVNIARPLDR 885
+V ED H+ +++V ATD+D NG V Y+I++ F+IDS+TG + + PLD
Sbjct: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
Query: 886 ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTV 945
E + E++L+I A+D R P +T + + + D+ND+ P F+ ++V V E+ P G
Sbjct: 611 EAEREYALRIRAQDAGR-PPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
Query: 946 IMWLEAHDPDLGQSGQVRYSLLDHG-EGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
++ ++A D D G++ ++ YSL + F ++ +G V + LD E + Y V A+
Sbjct: 670 VIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR 729
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
D G P LS++ V V V+DVN+N P F+ + EDA VG+ V++V+A D DA
Sbjct: 730 DHGSP-PLSASASVTVTVLDVNDN--RPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA- 785
Query: 1065 RDGEIRYSIRDGSGVGVFKIGEETGV--IETSDRLDRESTSHYWLTVFATDQGVVPLSSF 1122
+ I Y I G+ F I + GV + + LD + ++ L + A+D+ L
Sbjct: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDH 841
Query: 1123 IEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGN 1182
++I + D N + P Y + E+ P ++V I A D D N ++ Y +
Sbjct: 842 CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL 901
Query: 1183 PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
PQ F I +G IT + LD E Q + L +T DNG P K+ V V + D NDN
Sbjct: 902 PQ--FRIDADSGAITLQA-PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 958
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNE-HGKFF 1301
PQF+ Y + E P + + ATD+D N + Y+ ++G + G F
Sbjct: 959 PQFVASHYTGLVSEDAPPFTS-------VLQISATDRDAHANGRVQYTFQNGEDGDGDFT 1011
Query: 1302 IEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPI 1356
IEP +G+V + R A Y+ L+ AVD G P + + ++ ++ ++ P
Sbjct: 1012 IEPTSGIVRTVRRLDREAVSVYE-LTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
Query: 1357 SFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416
FE +++ S VA + V E P + + I GN F +D +G +
Sbjct: 1071 EFEVRVKENSIVGS-VVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALID 1129
Query: 1417 LDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRP-----QFSTSKYEVVIPEDTAP 1471
LD E + Y + V+AT V ++++D ND+ P Q + Y V DT P
Sbjct: 1130 LDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNY-VSNRSDTFP 1188
Query: 1472 ETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLT 1531
I +I A D D + L Y+ + + L+ ++ +G L S KLD+ ++
Sbjct: 1189 SGIIGRIPAYDPDVSDHLFYSFERGNE---LQLLVVNQTSGELRLSRKLDNNRPLVASML 1245
Query: 1532 VMVRD 1536
V V D
Sbjct: 1246 VTVTD 1250
Score = 324 bits (830), Expect = 1e-87
Identities = 270/999 (27%), Positives = 444/999 (44%), Gaps = 103/999 (10%)
Query: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-----KDRTDMFAIHPTS 201
P F +Y +PEN A T++ RV A D D G G YS ++F+I P S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 202 GVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261
G+I LD + + + + A D +GS +S+ + V + N+ +PV
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQD-----HGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 262 LSPSELDR-DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFP-GSKEYKVKA 319
+ + + Y I+ + D A + G + +F + +
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 320 IGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISE 378
G +D + H Y L ++A D+G P S V +H+T +F + Y A++ E
Sbjct: 498 SGRVDRE-HMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
Query: 379 FAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHF 434
P+T V+ V A A + Y S + F+++ TG I ++ P+ + +
Sbjct: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
Query: 435 ELEVTTSD------RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAV 488
L + D + ++V+ N + P F T ++ + EN P+G +V+ + AV
Sbjct: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
Query: 489 DPDEGENGYVTYSIANL-NHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY 547
D D GEN + YS+ + PF I+ TG VS S LD E + Y + A D G P
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH-YFFGVEARDHGSP- 734
Query: 548 RREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIE 607
T+T+ ++NDN P F + D VG + +V+A+D D + YQI
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQIT 794
Query: 608 AGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASH 667
GN + F+++ GV GL +T ++ Y + + AS
Sbjct: 795 GGNTRNRFAISTQGGV---------GL----------VTLALPLDYKQERYFKLVLTASD 835
Query: 668 KLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVK 727
+ ++ C + + N H P F+S + V
Sbjct: 836 RALHDHCY--------------------------VHINITDANTHRPVFQSA-HYSVSVN 868
Query: 728 ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC--FMIDMETGMLKILSPLDRETT 785
E++P+GS+++ ++++D D G N ++ Y + ED+ F ID ++G + + +PLD E
Sbjct: 869 EDRPMGSTIVVISASDDDVGENARITYLL----EDNLPQFRIDADSGAITLQAPLDYEDQ 924
Query: 786 DKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
YTL IT D GIPQKA + V+V D NDN P+F+ Y VSED + ++Q+
Sbjct: 925 VTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQIS 984
Query: 846 ATDKDLGPNGHVTYSIVTDTD---TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
ATD+D NG V Y+ D F+I+ +G+V R LDRE + L A D R
Sbjct: 985 ATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD--R 1042
Query: 903 EEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQV 962
P L + V ++V ++DVNDN P F + V+V+E+ G+V+ + A DPD G + +
Sbjct: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
Query: 963 RYSLLDHGEGN----FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
Y ++ EGN F +D SG + + LD+E +Q Y + V+A L S V
Sbjct: 1103 MYQIV---EGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS----APLVSRATV 1155
Query: 1019 EVEVVDVNENLHPPVFSSFV----EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
V +VD N+N PV ++F + + D ++ + A+D D + YS
Sbjct: 1156 HVRLVDQNDN--SPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDV--SDHLFYSFE 1211
Query: 1075 DGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD 1113
G+ + + + + +G + S +LD + V TD
Sbjct: 1212 RGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
Score = 306 bits (785), Expect = 2e-82
Identities = 270/978 (27%), Positives = 452/978 (46%), Gaps = 71/978 (7%)
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE---DGNEHGK 1299
PQF Q Y+ +PE E A + V+A D D G + YS+ +
Sbjct: 323 PQFPQYNYQTLVPENE-------AAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
Query: 1300 FFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKP--KPSLEP 1355
F I+P++G++ + + E L + A D+G P+ S+TT + + + P E
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG-----GNYDSHFDVDKGTGT 1410
+ E+ V E P+ + PP L + G + F++D +G
Sbjct: 436 AQYRETLRE-NVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 1411 IIVAKPLDAEQKSNYNLTVEATD-----GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
I + +D E +Y L VEA+D G + +V I V+D ND+ PQFS +Y +
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
Query: 1466 PEDTAPETEILQISAVDQD-EKNKLI-YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523
ED P T +L+++A D+D + N L+ Y + S S F +D TG + LD E
Sbjct: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGN---SRGHFAIDSLTGEIQVVAPLDFE 611
Query: 1524 AVHQHTLTVMVRDQD-VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
A ++ L + +D P+ N + V D NDH P F ++ ++ V E+A +G V+
Sbjct: 612 AEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVI 671
Query: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642
+ A+D D G+NA + YS+ F+I+ G + + LDR + Y V+A D
Sbjct: 672 HIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
Query: 1643 GSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA---HSQSSVVY 1699
GSPP+S SV + V ++ P+FT KEY + L+E ++G+ V VTA + S++ Y
Sbjct: 732 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISY 791
Query: 1700 EIKDGNTGDAFDINPHSGTIITQKA--LDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQD 1757
+I GNT + F I+ G + A LD++ + L++ ++ A L + V +++ D
Sbjct: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITD 850
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVH 1817
N + PVF A Y+ ++E + S + +VI A+D D NA + Y ++E ++
Sbjct: 851 ANTHRPVFQSAHYSVSVNEDRPMGSTI-------VVISASDDDVGENARITY-LLEDNL- 901
Query: 1818 TYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPP 1877
F ID+ +GAI LDYE+ + + D G P+ V V V D+ND P
Sbjct: 902 PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ--KADTTYVEVMVNDVNDNAP 959
Query: 1878 VFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGE-KFSMDYKTGAL 1936
F Y + V+ ++ATD D+ A ++ Y+ G G+ F+++ +G +
Sbjct: 960 QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
Query: 1937 -TVQN-TTQLRSRYELTVRASDGRFAGL---TSVKINVKESKESHLKFTQDVYSAVVKEN 1991
TV+ + S YELT A D L S+++ V++ ++ F + + VKEN
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
Query: 1992 STEAETLAVITAI--GNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047
S +A ITA+ N + Y I+ N F++ SG L T D E ++ +
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYEARQEY 1138
Query: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY----YAVVKVDTEVGHVIRYV 2103
+VV+ T V+ V V + DQNDN+PV N Y + DT +I +
Sbjct: 1139 VIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRI 1195
Query: 2104 TAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEIS--LKKQFELDTLNKEYLVTVVAKDGGN 2161
A D D + +Y E Q+ + + S L+ +LD +V G
Sbjct: 1196 PAYDPDV---SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGL 1252
Query: 2162 PAFSAEVIVPITVMNKAM 2179
+ +A+ ++ + ++ + +
Sbjct: 1253 HSVTAQCVLRVVIITEEL 1270
Score = 302 bits (773), Expect = 6e-81
Identities = 276/982 (28%), Positives = 425/982 (43%), Gaps = 58/982 (5%)
Query: 1645 PPMSEITSV-RIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VV 1698
P ++TS R A N P+F Y + E + G+ V V A + +V
Sbjct: 302 PEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLV 361
Query: 1699 YEIK---DGNTGDAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLV 1753
Y + + + + F I+P SG I T ALD E++ + L + Q LS T V V
Sbjct: 362 YSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAV 421
Query: 1754 HLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVE 1813
+ D ND++PVF QA+Y + E+ +L +RA D D NA L Y V
Sbjct: 422 TVADRNDHSPVFEQAQYRETLRENVEEGYPILQ-------LRATDGDAPPNANLRYRFVG 474
Query: 1814 P-----SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868
P + F ID +G I T +D E + V+ D G V +
Sbjct: 475 PPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHIT 534
Query: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
V+D ND P F++ Y A + V+ V ATD D A + Y+I GN F+
Sbjct: 535 VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFA 594
Query: 1929 MDYKTGALTVQNTTQLRSR--YELTVRASDGRFAGLTS----VKINVKESKESHLKFTQD 1982
+D TG + V + Y L +RA D L++ I V + + F
Sbjct: 595 IDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVST 654
Query: 1983 VYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILN--PDRRFKISRTSGVLSTTGTP 2038
+ V EN+ ++ I A+ + N L Y + PD F I+ +G +S +G P
Sbjct: 655 PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-P 713
Query: 2039 FDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098
DRE E + VE + P A V V V D NDN P F Y+ + D VG
Sbjct: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
Query: 2099 VIRYVTAVDRDSGRNGEVHYYLK--EHHEHFQIGPLGEISLKK-QFELDTLNKEYLVTVV 2155
+ VTAVDRD+ N + Y + F I G + L LD + Y V+
Sbjct: 774 SVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVL 831
Query: 2156 AKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP---EGL 2212
V + IT N PVF+ YS + E + S +V + A+ E
Sbjct: 832 TASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENA 891
Query: 2213 KVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEV-FVDI 2271
++ Y + D P QF I+ ++G I + APLD+E Y L+I A D+ A+ +V++
Sbjct: 892 RITYLLEDNLP--QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEV 949
Query: 2272 IVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHD 2331
+V+D+NDN P F Y +SE + TSV+Q+ ATD D+ N + Y F N
Sbjct: 950 MVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT-FQNGEDGDG 1008
Query: 2332 HFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
F ++ ++G++ +R LD E + + AVD G+P L + V + V V D+NDN P+F
Sbjct: 1009 DFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFP 1068
Query: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN 2451
+ +E R+ E++ G V + A D D + Y I+ GN + F +D +G +T
Sbjct: 1069 AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
Query: 2452 LHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPA-----FLQNEYEVELAENAP 2506
+ + Y + + + S VHV ++ N +SP L N Y ++ P
Sbjct: 1129 DLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP 1188
Query: 2507 LHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
++ + D D + H+ Y +N+ G++ KLD P V S
Sbjct: 1189 -SGIIGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPL--VAS 1243
Query: 2566 VRLMAKDAGGKV-AFCTVNVIL 2586
+ + D V A C + V++
Sbjct: 1244 MLVTVTDGLHSVTAQCVLRVVI 1265
Score = 261 bits (668), Expect = 9e-69
Identities = 279/1034 (26%), Positives = 447/1034 (43%), Gaps = 134/1034 (12%)
Query: 33 QFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHP-AWEVRYKIVSGDSENLFKAEEYILG 91
QF Y V EN AA T V + V P A E + S + ++ E
Sbjct: 324 QFPQYNYQTLVPENEAAGTAV-----LRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 92 DFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNT-NVEARTKVRVQVLDTNDLRPLFS 150
D IRT A L+RE + + L V A + + + A T V V V D ND P+F
Sbjct: 379 DPQSGLIRT----AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFE 434
Query: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-------KDRTDMFAIHPTSGV 203
Y +L EN I ++ ATD D N Y F F I P SG+
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 204 IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---V 260
I +GR+D + YE+ + A+D+G + S+ ++ + + N+ AP + V
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQE---PGPRSATVRVHITVLDENDNAPQFSEKRYV 551
Query: 261 TLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAI 320
++ VT D D+ ANG + +I++G+ F + S G +++ +
Sbjct: 552 AQVREDVRPHTVVLRVTATDRDKDANG-LVHYNIISGNSRGHF-AIDSLTG----EIQVV 605
Query: 321 GGIDWDSHPFGYNLTLQAKDKGTPP-----QFSSVKVIHVTS--PQFKAGPVKFEKDVYR 373
+D+++ Y L ++A+D G PP +S++V+ + P F + P ++
Sbjct: 606 APLDFEAER-EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTP-------FQ 657
Query: 374 AEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ 429
+ E AP V+ ++A+ A + L Y F +N TG +S+ P+ R+
Sbjct: 658 VSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE 717
Query: 430 QAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS 484
H+ V D AS V V VL N N PEFT Y +E+ +GT+V+S
Sbjct: 718 SVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS 777
Query: 485 LSAVDPDEGENGYVTYSIA---NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
++AVD D N ++Y I N + G V+ + LDY+ R + L + AS
Sbjct: 778 VTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK-QERYFKLVLTAS 834
Query: 542 DWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--EL 599
D L V I + + N + P+F+ + ++ D +G I +SA D D E
Sbjct: 835 DRALHDHCYVH----INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGEN 890
Query: 600 QLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPL 657
+ Y +E + L F ++ +SG ++L+ L +V++ +L ITA D A
Sbjct: 891 ARITYLLE--DNLPQFRIDADSGAITLQAPL--DYEDQVTY-TLAITARDNGIPQKADTT 945
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
Y+ + V + VN + PQF
Sbjct: 946 YVEVMV-------------------------------------------NDVNDNAPQFV 962
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKI 776
++ TG+ V E+ P +SV+ +++TD D NG++ Y G + D F I+ +G+++
Sbjct: 963 ASHYTGL-VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRT 1021
Query: 777 LSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKE 836
+ LDRE Y L D G+P + V+V D NDN P F E + V V E+
Sbjct: 1022 VRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
Query: 837 VHSEIIQVEATDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLK 894
V S + Q+ A D D GPN H+ Y IV + F +D +G + LD E + E+ +
Sbjct: 1082 VGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIV 1141
Query: 895 IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF----IPPNYRVKVREDLPEGTVIMWLE 950
++A L S V V L D NDN P I N V R D +I +
Sbjct: 1142 VQA-----TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
Query: 951 AHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKP 1009
A+DPD+ S + YS E V++ SG +R+ ++LD + V ++ V D
Sbjct: 1197 AYDPDV--SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLH- 1253
Query: 1010 VSLSSTCYVEVEVV 1023
S+++ C + V ++
Sbjct: 1254 -SVTAQCVLRVVII 1266
Score = 217 bits (553), Expect = 2e-55
Identities = 232/906 (25%), Positives = 387/906 (42%), Gaps = 109/906 (12%)
Query: 24 SQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITH----PAWEVRYKIVSGDS 79
+ R + +P+ F +Y T++EN G+P+ + + T P +RY+ V +
Sbjct: 424 ADRNDHSPV-FEQAQYRETLRENVEE----GYPI-LQLRATDGDAPPNANLRYRFVGPPA 477
Query: 80 ENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEART---KVR 136
A + + L I T G ++RE + Y L+V+A ++ R+ +V
Sbjct: 478 ARAAAAAAFEIDPRSGL-ISTSGR----VDREHMESYELVVEASDQGQEPGPRSATVRVH 532
Query: 137 VQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF--KDRTDM 194
+ VLD ND P FS Y + E+ T + RV+ATD D NG +Y+ +
Sbjct: 533 ITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGH 592
Query: 195 FAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGM-KLYGSSGISSMAKLTVHIEQANEC 253
FAI +G I + LD+ + Y + I A D G L ++G++S + + N+
Sbjct: 593 FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS-----IQVVDINDH 647
Query: 254 APVITAVTLSPSELDRDP-AYAIVTVD--DCDQGANGDIA-SLSIVAGDLLQQFRTVRSF 309
P+ + S L+ P ++++ + D D G N + SL+ VA D + +
Sbjct: 648 IPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGW 707
Query: 310 PGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEK 369
V G +D +S Y ++A+D G+PP +S V VT +F
Sbjct: 708 -------VSVSGPLDRESVEH-YFFGVEARDHGSPPLSASASVT-VTVLDVNDNRPEFTM 758
Query: 370 DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAK----FSLNYNTGLISILEP 425
Y ++E A T VV V A+ ++ ++ T G + S GL+++ P
Sbjct: 759 KEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALP 818
Query: 426 VKRQQAAHFELEVTTSDRKASTK--VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
+ +Q +F+L +T SDR V + + AN++ P F Y + +E+ P+G+T++
Sbjct: 819 LDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV 878
Query: 484 SLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDW 543
+SA D D GEN +TY + + N F ID +GA++ LDYE YTL I A D
Sbjct: 879 VISASDDDVGENARITYLLED-NLPQFRIDADSGAITLQAPLDYEDQV-TYTLAITARDN 936
Query: 544 GLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--L 601
G+P + + + +N++NDN P F + G + D + +SA D D
Sbjct: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995
Query: 602 VQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLY 658
VQY + G + D F++ P SG++ R L VS + L A D TP+
Sbjct: 996 VQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD---REAVSVYELTAYAVDRGVPPLRTPVS 1052
Query: 659 INITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRS 718
I + V VN + P F +
Sbjct: 1053 IQVMV-------------------------------------------QDVNDNAPVFPA 1069
Query: 719 TLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILS 778
++VKEN VGS V + + D D G N ++Y + GN F +D+ +G L L
Sbjct: 1070 E-EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
Query: 779 PLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPP-----EFLQESYFVEVSE 833
LD E +Y + + + +A +HV +VD NDN P + L +Y V
Sbjct: 1129 DLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQNDNSPVLNNFQILFNNY-VSNRS 1184
Query: 834 DKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSL 893
D I ++ A D D+ + ++ + ++ +G + ++R LD S+
Sbjct: 1185 DTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASM 1244
Query: 894 KIEARD 899
+ D
Sbjct: 1245 LVTVTD 1250
Score = 172 bits (435), Expect = 9e-42
Identities = 155/587 (26%), Positives = 257/587 (43%), Gaps = 53/587 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE +HY V+A + + + A V V VLD ND RP F+ Y + L E+ A+ T
Sbjct: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGV--IVLTGRLDYLETKLYEMEILA 224
S+ V+A D D + + + + + FAI GV + L LDY + + +++ + A
Sbjct: 774 SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA 833
Query: 225 ADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQG 284
+DR + + ++I AN PV + S S + P + + V
Sbjct: 834 SDR--------ALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
Query: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTP 344
G+ A ++ + D L QFR + + +D++ Y L + A+D G
Sbjct: 886 DVGENARITYLLEDNLPQFRI-----DADSGAITLQAPLDYEDQ-VTYTLAITARDNGI- 938
Query: 345 PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSH----LRY 400
PQ + + V +F Y +SE APP T V+ + A +H ++Y
Sbjct: 939 PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY 998
Query: 401 VFKS-TPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVL 454
F++ G F++ +G++ + + R+ + +EL DR + + V V
Sbjct: 999 TFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQ 1058
Query: 455 GANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--FAI 512
N N P F ++ EN +G+ V ++AVDPDEG N ++ Y I N +P F +
Sbjct: 1059 DVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGN-IPELFQM 1117
Query: 513 DHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKI 572
D F+G ++ +LDYE + Y + ++A+ L R V V L + NDN+P+
Sbjct: 1118 DIFSGELTALIDLDYEAR-QEYVIVVQATSAPLVSRATVHV----RLVDQNDNSPVLNNF 1172
Query: 573 ---------NCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGV 623
N T P + I + A D D + Y E GNEL +N SG
Sbjct: 1173 QILFNNYVSNRSDTFPSGI-----IGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGE 1227
Query: 624 LSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLV 670
L L R L + + S+ +T TDG + T + V + +L+
Sbjct: 1228 LRLSRKLDNN---RPLVASMLVTVTDGLHSVTAQCVLRVVIITEELL 1271
Score = 84.7 bits (208), Expect = 2e-15
Identities = 40/100 (40%), Positives = 54/100 (54%), Gaps = 6/100 (6%)
Query: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQL-- 4089
P G C+C + G CE ++ C S PC GG C GG+ C CR +TG+ C+L
Sbjct: 1415 PIAGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDT 1474
Query: 4090 -SPYCKDEPCKNGGTCFDSLDGAV-CQCDSG--FRGERCQ 4125
+ C C+NGGTC D+ +G CQC +G F G RC+
Sbjct: 1475 EAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCE 1514
Score = 83.6 bits (205), Expect = 4e-15
Identities = 99/403 (24%), Positives = 144/403 (35%), Gaps = 67/403 (16%)
Query: 3787 CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG---QCPGSSSMTLTGNSYVKYR 3843
C H C+ PC C S+ W +C CP G G Q + GN + +
Sbjct: 1719 CQAKLHFCDSGPCKNSGFC-SERWGS-FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWN 1776
Query: 3844 L-TENENKLEMKLTMRLRTYSTHAVVMYARGTDYSIL--EIHHGRLQYKFDCGSGPGI-V 3899
++ + L + RT +T V+M + +S L ++ G L GSG +
Sbjct: 1777 FGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHL 1836
Query: 3900 SVQSIQVNDGQWHAVALEV-------NGNYARLV-----LDQVHTASGTAPGTLKTLNLD 3947
+ + V+DG+WH + LE+ G++ +V L Q A G+ LK L
Sbjct: 1837 LLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQL- 1895
Query: 3948 NYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSP 4007
H+ G G + + G GC+ ++L S + V+ P
Sbjct: 1896 -------HV--GGLPPGSAEEAPQGLVGCIQGVWLGSTP----SGSPALLPPSHRVNAEP 1942
Query: 4008 GCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTC 4067
GC T CAS PC C + C C Y G C V+ C PC G+C
Sbjct: 1943 GC--VVTNACASGPCPPHADCR-DLWQTFSCTCQPGYYGPGC---VDACLLNPCQNQGSC 1996
Query: 4068 VVDNG---GFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERC 4124
G G+ C C G Y G C+ + D+ C G + C GF
Sbjct: 1997 RHLPGAPHGYTCDCVGGYFGHHCE---HRMDQQCPRGWWGSPTCGPCNCDVHKGFDPN-- 2051
Query: 4125 QSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAP 4167
C T+G HC H YR R + P
Sbjct: 2052 -----------------CNKTNGQCHCKEFH-YRPRGSDSCLP 2076
Score = 66.6 bits (161), Expect = 5e-10
Identities = 35/84 (41%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP--CSSKPCLYGGTCV- 4068
T + C SNPC+NGG C GGY C C + G CE+ C C GGTC
Sbjct: 1434 TELDLCYSNPCRNGGAC-ARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTD 1492
Query: 4069 VDNGGFVCQC--RGLYTGQRCQLS 4090
NGGF CQC G + G RC+++
Sbjct: 1493 APNGGFRCQCPAGGAFEGPRCEVA 1516
Score = 61.2 bits (147), Expect = 2e-08
Identities = 33/100 (33%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 4073 GFVCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDID-- 4129
G C+C +TG C+ C PC+NGG C G C C F GE C+ D +
Sbjct: 1418 GLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAG 1477
Query: 4130 ECSGNPCLHGALCENT-HGSYHCNC--SHEYRGRHCEDAA 4166
C C +G C + +G + C C + G CE AA
Sbjct: 1478 RCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAA 1517
Score = 60.5 bits (145), Expect = 4e-08
Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 22/93 (23%)
Query: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130
C EPC+N C FDS + G C+C GF G+ C++++D
Sbjct: 1379 CLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDL 1438
Query: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
C NPC +G C G Y C C + G CE
Sbjct: 1439 CYSNPCRNGGACARREGGYTCVCRPRFTGEDCE 1471
Score = 52.0 bits (123), Expect = 1e-05
Identities = 27/86 (31%), Positives = 35/86 (40%), Gaps = 6/86 (6%)
Query: 4087 CQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCENTH 4146
C ++ C PC C D C C G+ G C +D C NPC + C +
Sbjct: 1944 CVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLP 2000
Query: 4147 GS---YHCNCSHEYRGRHCEDAAPNQ 4169
G+ Y C+C Y G HCE Q
Sbjct: 2001 GAPHGYTCDCVGGYFGHHCEHRMDQQ 2026
Score = 42.0 bits (97), Expect = 0.014
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 17/74 (22%)
Query: 4124 CQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE--DAAPNQY----------- 4170
CQ+ + C PC + C GS+ C+C + G+ C+ A P+ +
Sbjct: 1719 CQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFG 1778
Query: 4171 ----VSTPWNIGLA 4180
VS PW +GLA
Sbjct: 1779 SDMAVSVPWYLGLA 1792
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 453 bits (1165), Expect = e-126
Identities = 418/1508 (27%), Positives = 658/1508 (43%), Gaps = 191/1508 (12%)
Query: 2702 KFSEPFYTFTVSEDVPIGTEIDLIRAEHS-----GTVLYSLVKGNTPESNRDESFVIDRQ 2756
KF P Y + E+ P GT I + A ++ V Y + +G E +R F ID
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGY-FRIDSA 301
Query: 2757 SGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEA 2816
+G + + LD ET + + + A A+ +++ VKD ND+SPVFE S Y
Sbjct: 302 TGAVSTDSVLDRETKETHVLRVKA-VDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360
Query: 2817 FIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELD 2876
+ ENL G V+ IRASD DS N + Y + + F +N +G ++T LD
Sbjct: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNESSGVVSTRAVLD 416
Query: 2877 HEKRDNYQIKVVASDHGEKI-QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGG 2935
E+ YQ+ V A+D G LS+TA V + V D ND+ P+F+ + Y V ED
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 2936 VIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLT 2995
+ + TD D + N + Y I G+ GQF + ++ V PLD E Y L+
Sbjct: 477 AVLRVQATDRDQGQ-NAAIHYSILSGNVAGQFYLHSLSGILDVI--NPLDFEDVQKYSLS 533
Query: 2996 ITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD 3051
I A DG +S +V V+VLD NDN P+ + + T+ E+V G ++ I A DAD
Sbjct: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
Query: 3052 IRSNAEITY-------TLLGSGAE-----------KFKLNPDTGELKTSTPLDREEQAVY 3093
NA + Y T LG G+ F+++ +G + LDREE Y
Sbjct: 594 SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHY 653
Query: 3094 HLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATD 3151
V A D G S+ +T+ DVNDN P F+ Y + + E+ G+ + +QA D
Sbjct: 654 SFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARD 713
Query: 3152 ADAGLNRKILYSLID-SADGQFSINEL--SGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208
DA N I Y L + +F+++ G+I L PLD + + Y L++ A D
Sbjct: 714 RDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---- 767
Query: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYS 3268
+ T V+++V D N + PVF+ Y +VSED VGT + + A D NA ITY
Sbjct: 768 TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
Query: 3269 IISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDI 3328
I + +F ID +G ++ + LDYE+ Y LT+ A D G P SD T+ + + D
Sbjct: 828 I--QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDA 885
Query: 3329 NDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDP 3387
NDN P F D Y I EDA S++ V A D D N + Y+ G+ G F I+P
Sbjct: 886 NDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEP 945
Query: 3388 VRGEVKVTKLLDRETISGYTLTVQASDNGSP-PRVNTTTVNIDVSDVNDNAPVFSRGNYS 3446
G ++ + LDRE ++ Y L A D GSP P + + + + D+NDNAP+F +
Sbjct: 946 TSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELE 1005
Query: 3447 VIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKR 3505
+ ++EN PVG V ++ D D N + IV G+ F+++ G L +
Sbjct: 1006 LFVEENNPVGSVVAKIRANDPDEGPNAQ-IMYQIVEGDMRHFFQLDLLNGDLRAMVELDF 1064
Query: 3506 KEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSG 3561
+ + Y+L V+ P +S T + I +++++ PP + +I ++T+ +
Sbjct: 1065 EVRREYVLVVQATS--APLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 3562 GVIGKIHATDQDVYDTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIG---QYLLNVSVT 3617
GVIG I A D DV D+L Y+ + L + G+L + LD + L+ VSV+
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVS 1181
Query: 3618 DGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRND 3677
DG + A T+ + +T +ML ++I +R N++ E+F+ F + +L ++D
Sbjct: 1182 DGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDD 1241
Query: 3678 IQIVSLQSSEPHPH--LDVLLFVEKPGSAQ---ISTKQLLHKINSSVTDIEEIIGVRILN 3732
+ + ++Q+ L+V PG + ++ L +I + T + I R+L
Sbjct: 1242 VFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLP 1301
Query: 3733 VFQKLCAGLDCP-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVH 3791
+C C + C + D S ST L P H + RCPP
Sbjct: 1302 FDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVL--FRPIHPINGL----RCRCPPGF 1355
Query: 3792 HG---------CEDDPCPEGSECVSDPWEEKHTCVC----------PSGRFGQC------ 3826
G C DPC C S E +TC C R G+C
Sbjct: 1356 TGDYCETEIDLCYSDPCGANGRCRSR--EGGYTCECFEDFTGEHCEVDARSGRCANGVCK 1413
Query: 3827 ------------------PGS--------SSMTLTGNSYVKYRLTENENKLEMKLTMRLR 3860
PG ++ + S+V +R + +++
Sbjct: 1414 NGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFR--GLRQRFHFTISLTFA 1471
Query: 3861 TYSTHAVVMY----ARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQ-SIQVNDGQWHAVA 3915
T + +++Y D+ LEI ++Q F G V+ + V+DG+WH+V
Sbjct: 1472 TQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQ 1531
Query: 3916 LEV----------------NGNYARLVLDQVHT----------------ASGTAPGTLKT 3943
++ A + +D T A GT G+ K+
Sbjct: 1532 VQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKS 1591
Query: 3944 LNLDNYVFFGG--HIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEE 4001
L+L + GG ++ + H R F GCM ++ ++G+ + + A
Sbjct: 1592 LDLTGPLLLGGVPNLPEDFPVHNRQ------FVGCMRNLSVDGKNVDM-------AGFIA 1638
Query: 4002 SVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPC 4061
+ GC C CQNGG C + Y C+C + G +CE ++ P
Sbjct: 1639 NNGTREGC-AARRNFCDGRRCQNGGTC-VNRWNMYLCECPLRFGGKNCEQAM----PHPQ 1692
Query: 4062 LYGGTCVV 4069
L+ G VV
Sbjct: 1693 LFSGESVV 1700
Score = 449 bits (1156), Expect = e-125
Identities = 314/956 (32%), Positives = 484/956 (50%), Gaps = 51/956 (5%)
Query: 2492 FLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDF-AKDRFYI---NERGQ 2547
F Y+V L EN P TL++++ G V+Y++ F + R Y + G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 2548 IFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607
+ T LDRET V+ V+ + + A + V++ D ND++P F ++Y +
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667
+ G V+ + ASD D NA++ Y + + V ++N+ SGV++T+ L E
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV---FQLNESSGVVSTRAVLDREEAA 421
Query: 2668 FFTFFVRAVDNG-SPSKESVVL-VYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI 2725
+ V A D G +P S VY+++ P+FSE Y V EDV + T + +
Sbjct: 422 EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
Query: 2726 RAE-----HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILA 2780
+A + + YS++ GN F + SG L + LD E + Y SI A
Sbjct: 482 QATDRDQGQNAAIHYSILSGNVAGQ-----FYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
Query: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
+ + +S VS+QV D NDN P+F SSP++A ++EN+P G V+ I+A DADSG
Sbjct: 537 QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 2841 NGQVMYSLDQSQSVEVIES--------------FAINMETGWITTLKELDHEKRDNYQIK 2886
N ++ Y L + S + F I+ +GWIT ELD E+ ++Y
Sbjct: 597 NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
Query: 2887 VVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDAD 2946
V A DHG SST+ V +TV DVND+ P FT Y+ ++ED G + L D D
Sbjct: 657 VEAVDHGSPPMSSSTS-VSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 2947 SEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSK 3006
+ + +TY +TGG+ +FA+ + + + + PLD ++ Y+L +TA+DGT S
Sbjct: 716 ANSV---ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHT 772
Query: 3007 AIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSG 3066
A V + V DAN + PV + + Y+ ++ ED G I +SA D D NA ITY ++
Sbjct: 773 AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDP 831
Query: 3067 AEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE----DVNDNA 3122
+F+++PD+G + T LD E Q Y L + A D G Q S TLE D NDNA
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG--IPQKSDTTTLEILILDANDNA 889
Query: 3123 PEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLI--DSADGQFSINELSGI 3180
P+F D Y ++FE+ P T + +V ATD D+G N ++LY+ D DG F I SG+
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 3181 IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS 3240
I+ ++ LDRE AVY L AVD+G P L+A+ + V++LDINDN P+FE E V
Sbjct: 950 IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
Query: 3241 EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE 3300
E+ VG+ V ++ A D NA+I Y I+ G+ F +D G + + LD+E E
Sbjct: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
Query: 3301 YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS--QDTYTTVISEDAVLEQSVITVM 3358
Y L V+AT + L ATV++ + D NDN PV Q + ++ + + +
Sbjct: 1070 YVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
Query: 3359 ADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
D + ++Y+ + GN+ +DP GE+++++ LD + V SD
Sbjct: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 421 bits (1082), Expect = e-117
Identities = 328/1059 (30%), Positives = 512/1059 (48%), Gaps = 87/1059 (8%)
Query: 927 FIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL----DHGEGNFDVDKLSGA 982
F PNY+V + E+ P GT+I+ L AH G+ +V Y + + G F +D +GA
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 983 VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
V LD E K+ + L V+A D P S+T Y+ V V D N+ H PVF +
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPR-SATTYITVLVKDTND--HSPVFEQSEYRER 361
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
V+E+ VG V+T+ A D D+ + +RY + G+ VF++ E +GV+ T LDRE
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEA 420
Query: 1103 SHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ 1160
+ Y L V A DQG PLS+ +YIEVED NDN PQ SE Y ++ E+ + +V++
Sbjct: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
Query: 1161 IEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN 1220
++A D D N + Y I SGN G F +H +G++ + LD E ++ L + D
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYSLSIKAQDG 539
Query: 1221 GSPPKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
G PP + V+ V++LD NDN+P F+ ++ + E P+ H+ A D
Sbjct: 540 GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY-------PVVHIQAVDA 592
Query: 1280 DEGPNAEISYSIED-------GNEHGK----------FFIEPKTG--VVSSKRFSAAGEY 1320
D G NA + Y + D G G F I +G V ++ E+
Sbjct: 593 DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH 652
Query: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
++AVD+G P SS+T + I + +P+ F + + + E V + +
Sbjct: 653 YSFGVEAVDHGSPPMSSSTSVSITVLDVNDN--DPV-FTQPTYELRLNEDAAVGSSVLTL 709
Query: 1381 SVEP--PGIPLWFDITGGNYDSHFDVD--KGTGTIIVAKPLDAEQKSNYNLTVEATDGTT 1436
+ + +TGGN + F + +G G I +A PLD +Q+ Y L V A+DGT
Sbjct: 710 QARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
Query: 1437 TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQ 1494
+ V I V D N HRP F +S Y V + ED T I +SA D+D E ++ Y +Q
Sbjct: 770 SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
DP+ +FR+DP +G++YT +LD+E +TLT+M +D +P K + + + + D
Sbjct: 830 ---DPVP--QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILD 884
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMID 1613
ND+AP F Y+G ++E A + +LQV+A D+D G N +LY+ + G+ G+ F I+
Sbjct: 885 ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIE 944
Query: 1614 PVLGSIKTAKELDRSNQAEYDLMVKATDKGSP-PMSEITSVRIFVTIADNASPKFTSKEY 1672
P G I+T + LDR N A Y+L A D+GSP P+S +++ + ++ +P F E
Sbjct: 945 PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDEL 1004
Query: 1673 SVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDF 1727
+ + E +GS V + A+ + ++Y+I +G+ F ++ +G + LDF
Sbjct: 1005 ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDF 1064
Query: 1728 ETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTD 1787
E Y L++Q T+ A L + TV + L D+NDN PV ++ L + N V
Sbjct: 1065 EVRREYVLVVQATS-APLVSRATVHILLVDQNDNPPVL--PDFQILFN-----NYVTNKS 1116
Query: 1788 RNVPL-VIRAADA-DKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHF 1845
+ P VI A D D + L Y V+ + +D +TG + LD
Sbjct: 1117 NSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALM 1176
Query: 1846 TVQVHDMGTPRLFAEYAANVTVHVIDI----------NDCPPVFAKPLYE------ASLL 1889
V V D G + A VT+ D+ N F PL A++L
Sbjct: 1177 EVSVSD-GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVL 1235
Query: 1890 LPTYKGVKVITV-NATDADSSAFSQLIYSITEGNIGEKF 1927
T V V V N TD S+ + ++ G + +F
Sbjct: 1236 STTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQF 1274
Score = 366 bits (939), Expect = e-100
Identities = 297/1038 (28%), Positives = 496/1038 (47%), Gaps = 73/1038 (7%)
Query: 728 ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC---FMIDMETGMLKILSPLDRET 784
EN+P G+ ++ +++ G ++ Y + G ++ F ID TG + S LDRET
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 785 TDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQV 844
+ + L + D P ++A + V+V D ND+ P F Q Y V E+ EV E++ +
Sbjct: 316 KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
Query: 845 EATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903
A+D+D N ++ Y ++ D F ++ +GVV+ LDRE E+ L +EA DQ R
Sbjct: 376 RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435
Query: 904 EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR 963
L +T V + +ED NDN P F NY V+V ED+ T ++ ++A D D GQ+ +
Sbjct: 436 PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
Query: 964 YSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEV 1022
YS+L + G F + LSG + ++ LDFE Q Y+L+++A+D G+P ++S+ V V+V
Sbjct: 496 YSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQV 555
Query: 1023 VDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD------- 1075
+DVN+N P+F S + TV E+ P+G V+ + A D D+ + + Y + D
Sbjct: 556 LDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
Query: 1076 GSGVG----------VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEI 1125
G G F+I +G I LDRE HY V A D G P+SS +
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSV 673
Query: 1126 YIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQG 1185
I V DVNDN P ++P Y + E++ SV+ ++A D D +N + Y++T GN +
Sbjct: 674 SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRN 731
Query: 1186 FFSI-HPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQ 1244
F++ + G + T + LD +Q+ +++L VT +D +S A V++ + D N ++P
Sbjct: 732 RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPV 788
Query: 1245 FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP 1304
F Y + + E DR + + A D+D G NA I+Y I+D +F I+P
Sbjct: 789 FQSSHYTVSVSE----DRPVGT---SIATLSANDEDTGENARITYVIQD--PVPQFRIDP 839
Query: 1305 KTGVVSSKR---FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEES 1361
+G + + + Y L+I A DNG PQKS TT L I + + + F
Sbjct: 840 DSGTMYTMMELDYENQVAY-TLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ---FLWD 895
Query: 1362 FFTFTVMESDPVAHMIGVISVE-----PPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416
F+ ++ E P + I +S P G L+ G + D F ++ +G I +
Sbjct: 896 FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
Query: 1417 LDAEQKSNYNLTVEATD-GTTTILT---QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPE 1472
LD E + YNL A D G+ T L+ ++ + ++D ND+ P F + E+ + E+
Sbjct: 956 LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
Query: 1473 TEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTV 1532
+ + +I A D DE Q + F+LD G L +LD E ++ L V
Sbjct: 1016 SVVAKIRANDPDEGPNAQIMYQIVEGDMR-HFFQLDLLNGDLRAMVELDFEVRREYVLVV 1074
Query: 1533 MVRDQDVPVKRNFARIVVNVSDTNDHAPWFTA--SSYKGRVYESAAVGSVVLQVTALDKD 1590
+ + ++V+ +D P F ++Y S G V+ + A D D
Sbjct: 1075 QATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPD 1133
Query: 1591 KGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEI 1650
+ Y+ GN ++DP G ++ +++LD + E + V +D G ++
Sbjct: 1134 VSDSLN--YTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTAF 1190
Query: 1651 TSVRIFVTIADNASPKFTSKEYSVELSETVS--IGSFVGMVTAHSQSSVVYEIKDGNTGD 1708
++R+ + D + T + ++ + +S + FV V A V+ KD D
Sbjct: 1191 CTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAA-----VLSTTKD----D 1241
Query: 1709 AFDINPHSGTIITQKALD 1726
F N + T ++ L+
Sbjct: 1242 VFVFNVQNDTDVSSNILN 1259
Score = 357 bits (917), Expect = 1e-97
Identities = 287/1018 (28%), Positives = 471/1018 (46%), Gaps = 55/1018 (5%)
Query: 2595 QFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA-DSESVKENLEINKLSG 2653
+F Y+V + + GT ++++ A EG ++Y +E E + I+ +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713
++T L E V+AVD +P + + + V + P F + Y V
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 2714 EDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKW 2773
E++ +G E+ IRA + + + ++ D F ++ SG + LD E
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAE 422
Query: 2774 YQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIR 2832
YQ + A ++ + A+ V I+V+D NDN P F Y + E++ + V++++
Sbjct: 423 YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
Query: 2833 ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH 2892
A+D D G N + YS+ S V F ++ +G + + LD E Y + + A D
Sbjct: 483 ATDRDQGQNAAIHYSI---LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDG 539
Query: 2893 GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINR 2952
G ++S+ +V V V DVND+ P F + ++ TV E+ P G + + DADS E N
Sbjct: 540 GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE-NA 598
Query: 2953 QVTY--------FITGGD-------PLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTIT 2997
++ Y F+ GG P F + + + V LDRE+ ++Y +
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
Query: 2998 ATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRS 3054
A D SS V + VLD NDN PV + Y + ED G ++ + A D D +
Sbjct: 659 AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--A 716
Query: 3055 NAEITYTLLGSGAE-KFKLNPDTGE--LKTSTPLDREEQAVYHLLVRATDGGGRFCQASI 3111
N+ ITY L G +F L+ G + + PLD +++ Y L V A+DG R A +
Sbjct: 717 NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-RSHTAHV 775
Query: 3112 VLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ 3171
++ + D N + P F + Y ++V E+ GT + + A D D G N +I Y + D Q
Sbjct: 776 LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-Q 834
Query: 3172 FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFE 3231
F I+ SG + LD E Q YTL++ A D G+P++ T T+ + +LD NDN P F
Sbjct: 835 FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTT-TLEILILDANDNAPQFL 893
Query: 3232 YREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE-HGKFSIDSKTGAVFII 3290
+ Y ++ ED T +LQV A RD N + Y+ G++ G F I+ +G +
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
Query: 3291 ENLDYESSHEYYLTVEATDGGTPS-LSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAV 3349
LD E+ Y L A D G+P+ LS + V + DINDN P+F +D + E+
Sbjct: 954 RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
Query: 3350 LEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLT 3409
+ V + A+D D N+ I Y I++G+ F +D + G+++ LD E Y L
Sbjct: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
Query: 3410 VQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR-----GNYSVIIQENKPVGFSVLQLVV 3464
VQA+ S P V+ TV+I + D NDN PV NY + P G + +
Sbjct: 1074 VQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IGCIPA 1129
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
D D S + +T V GN+ + ++P G L S + L++V V+D G
Sbjct: 1130 HDPDVSDS---LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIH 1185
Query: 3524 QLSSLTYIDIRVIEESIYPPAI------LPLEIFITSSGEEYSGGVIGKIHATDQDVY 3575
+++ + + +I + + +I + E F++ + GV + T DV+
Sbjct: 1186 SVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVF 1243
Score = 353 bits (905), Expect = 3e-96
Identities = 323/1127 (28%), Positives = 502/1127 (44%), Gaps = 120/1127 (10%)
Query: 462 EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANL----NHVPFAIDHFTG 517
+F Y+ A EN P GT ++ L A EGE V+Y + L + F ID TG
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 518 AVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGT 577
AVST LD E + LR++A D+ P R + T+ + + ND++P+FE+
Sbjct: 304 AVSTDSVLDRETK-ETHVLRVKAVDYSTPPRSATTYI-TVLVKDTNDHSPVFEQSEYRER 361
Query: 578 IPRDLGVGEQITTVSAIDADEL--QLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLG 635
+ +L VG ++ T+ A D D ++Y++ G D F LN +SGV+S R+++D
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRV-LGGAWDVFQLNESSGVVST-RAVLDR-- 417
Query: 636 AKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHN 695
+ + + L + A D PL TV
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYI------------------------------ 447
Query: 696 QGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA 755
EVED N + PQF S +QV E+ + ++V+ + +TD D G N + Y+
Sbjct: 448 --EVED-------ENDNYPQF-SEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYS 497
Query: 756 VSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA-AWRLLHVVVVD 814
+ GN F + +G+L +++PLD E KY+L+I D G P + ++ V V+D
Sbjct: 498 ILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLD 557
Query: 815 ANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT------- 867
NDN P F+ + V E+ + ++ ++A D D G N + Y +V T
Sbjct: 558 VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
Query: 868 ------------FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKV 915
F I + +G + + LDRE +S +EA D P + S+ V +
Sbjct: 618 GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG--SPPMSSSTSVSI 675
Query: 916 SLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-- 973
++ DVNDN P F P Y +++ ED G+ ++ L+A D D + + Y L N
Sbjct: 676 TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
Query: 974 -FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPP 1032
+ G + + LD++++Q Y L V A D + S T +V + V D N H P
Sbjct: 734 ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR----SHTAHVLINVTDA--NTHRP 787
Query: 1033 VFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIE 1092
VF S +V ED PVG+ + T+SA+DED + I Y I+D V F+I ++G +
Sbjct: 788 VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD--PVPQFRIDPDSGTMY 845
Query: 1093 TSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENS 1152
T LD E+ Y LT+ A D G+ S + I + D NDNAPQ Y I E++
Sbjct: 846 TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
Query: 1153 PKDVSVVQIEAFDPDSSSNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEH 1211
P S++Q+ A D DS N +L+Y G+ G F I P +G+I T R+LDRE +
Sbjct: 906 PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVI-RTQRRLDRENVAVY 964
Query: 1212 ILEVTVTDNGSP-PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREP 1270
L D GSP P S + V ILD NDN P F E E E N
Sbjct: 965 NLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF-------EKDELELFVEENNPVGSV 1017
Query: 1271 LYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG---VVSSKRFSAAGEYDILSIKA 1327
+ + A D DEGPNA+I Y I +G+ F ++ G + F EY +L ++A
Sbjct: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREY-VLVVQA 1076
Query: 1328 VDNGRPQKSSTTRLHIEWISK-PKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPP 1385
P S T +HI + + P + P F+ F + +S+ +IG I P
Sbjct: 1077 --TSAPLVSRAT-VHILLVDQNDNPPVLP-DFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132
Query: 1386 GI--PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVF 1443
+ L + GN +D TG + +++ LD + + V +DG ++
Sbjct: 1133 DVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCT 1192
Query: 1444 IKV-IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAV----DQDEKNKLIYTLQSSRD 1498
++V I T+D T + E + E L + V + + ++ +Q+ D
Sbjct: 1193 LRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTD 1252
Query: 1499 P----LSLKKFRLDP--ATGSLYTSEKLDHEAVHQHTLTVMVRDQDV 1539
L++ L P G + SE L + TL + Q V
Sbjct: 1253 VSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRV 1299
Score = 341 bits (875), Expect = 9e-93
Identities = 278/980 (28%), Positives = 472/980 (48%), Gaps = 67/980 (6%)
Query: 2283 FAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHS-KSHDHFHVDSSTGL 2341
F +Y V L E GT ++Q+ A + +SY M G +S +F +DS+TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
+S LD E H + V+AVD P S+ +TV V D ND+ P+FEQ Y R+ E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFY 2461
+ G+ V ++A D DS L+Y +L G F ++ ++G+++ + Y
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
Query: 2462 SLNLSVSD-----GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKT 2516
L + +D G ++ V++ V N + P F + Y V++ E+ L+T V+ V+
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
Query: 2517 TDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGG 2575
TD D G + Y I++ +FY++ G + + LD E + +S++ A+D G
Sbjct: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK--AQDGGR 541
Query: 2576 KVAFCT---VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ V+V + D NDN P F ++ ++ + + G VV + A DAD G NA +
Sbjct: 542 PPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
Query: 2633 YAIEADSESVKEN---------------LEINKLSGVITTKESLIGLENEFFTFFVRAVD 2677
Y + + + +I+ SG IT L E E ++F V AVD
Sbjct: 602 YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
Query: 2678 NGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVL 2734
+GSP S V + +L P F++P Y ++ED +G+ + ++A + + +
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVIT 721
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVD 2794
Y L GNT NR + R G + L LD++ + Y ++ T D +
Sbjct: 722 YQLTGGNT--RNR-FALSSQRGGGLITLALPLDYKQEQQYVLAV----TASDGTRSHTAH 774
Query: 2795 VSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV 2854
V I V DAN + PVF+SS Y + E+ P G+ + + A+D D+G N ++ Y +
Sbjct: 775 VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ----- 829
Query: 2855 EVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDS 2914
+ + F I+ ++G + T+ ELD+E + Y + ++A D+G Q S T +++ + D ND+
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDN 888
Query: 2915 PPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQN 2974
P+F + Y+G++ ED P I +S TD DS R + F G D G F +E
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
Query: 2975 EWKVYVKKPLDREKRDNYLLTITATD----GTFSSKAIVEVKVLDANDNSPVCEKTLYSD 3030
+ ++ LDRE Y L A D S+ ++V +LD NDN+P+ EK
Sbjct: 949 --VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 3031 TIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREE 3089
+ E+ G ++ +I A D D NA+I Y ++ G F+L+ G+L+ LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV 1066
Query: 3090 QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAP-----EFSADPYAITVFENTEPGTLL 3144
+ Y L+V+AT +A++ + L D NDN P + + Y +T N+ P ++
Sbjct: 1067 RREYVLVVQAT-SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNY-VTNKSNSFPTGVI 1124
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQ-FSINELSGIIQLEKPLD--RELQAVYTLSLKA 3201
+ A D D ++ + Y+ + + + ++ +G +QL + LD R L+A+ +S
Sbjct: 1125 GCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS--- 1179
Query: 3202 VDQGLPRRLTATGTVIVSVL 3221
V G+ +TA T+ V+++
Sbjct: 1180 VSDGI-HSVTAFCTLRVTII 1198
Score = 331 bits (849), Expect = 9e-90
Identities = 292/1032 (28%), Positives = 466/1032 (45%), Gaps = 117/1032 (11%)
Query: 334 LTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEIS-EFAPPNTPVVMVKA 391
L L+A GTP S + P+ +AGP + + S +F PN V + +
Sbjct: 198 LALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFEN 257
Query: 392 IPAYS-----HLRYVFKSTPGKAK--------------FSLNYNTGLISILEPVKRQQAA 432
PA + H Y + + F ++ TG +S + R+
Sbjct: 258 EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKE 317
Query: 433 HFELEV-----TTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487
L V +T R A+T + V V N + P F Q+ Y+ EN+ +G V+++ A
Sbjct: 318 THVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRA 377
Query: 488 VDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGL-P 546
D D N + Y + F ++ +G VST LD E Y L + A+D G P
Sbjct: 378 SDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE-YQLLVEANDQGRNP 436
Query: 547 YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQY 604
I + + NDN P F + N +P D+G+ + V A D D+ Q + Y
Sbjct: 437 GPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY 496
Query: 605 QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664
I +GN F L+ SG+L + L V +SL I A DG P IN +
Sbjct: 497 SILSGNVAGQFYLHSLSGILDVINPLD---FEDVQKYSLSIKAQDG---GRPPLINSSGV 550
Query: 665 ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724
S ++++ VN + P F S+ P
Sbjct: 551 VSVQVLD-------------------------------------VNDNEPIFVSS-PFQA 572
Query: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYA--------VSGGN---------EDSCFMI 767
V EN P+G V+ + + D D+G N +L Y + GG+ D F I
Sbjct: 573 TVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI 632
Query: 768 DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESY 827
+G + + + LDRE + Y+ + D G P ++ + + V+D NDN P F Q +Y
Sbjct: 633 HNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTY 692
Query: 828 FVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVT--GVVNIARPL 883
+ ++ED V S ++ ++A D+D N +TY + + F++ S G++ +A PL
Sbjct: 693 ELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
Query: 884 DRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEG 943
D + + ++ L + A D R T V +++ D N + P F +Y V V ED P G
Sbjct: 751 DYKQEQQYVLAVTASDGTRSH-----TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
Query: 944 TVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA 1003
T I L A+D D G++ ++ Y + D F +D SG + + +LD+E + Y LT+ A
Sbjct: 806 TSIATLSANDEDTGENARITYVIQD-PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 1004 KDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDA 1063
+D G P S T +E+ ++D N+N P F +G++ EDAP + ++ VSA D D+
Sbjct: 865 QDNGIP-QKSDTTTLEILILDANDN--APQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
Query: 1064 RRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG-VVPLSS 1121
+G + Y+ + G G G F I +GVI T RLDRE+ + Y L A D+G PLS+
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181
+EI + + D+NDNAP + + EN+P V +I A DPD N ++MY+I G
Sbjct: 982 SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
Query: 1182 NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDN 1241
+ + FF + G + +LD E + E++L V T S P + A V + ++D+NDN
Sbjct: 1042 DMRHFFQLDLLNGDLRAMV-ELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDN 1097
Query: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF 1301
P L F L ++ + + + A D D + ++Y+ GNE
Sbjct: 1098 -PPVLPDFQ--ILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDS--LNYTFVQGNELRLLL 1152
Query: 1302 IEPKTGVVSSKR 1313
++P TG + R
Sbjct: 1153 LDPATGELQLSR 1164
Score = 291 bits (744), Expect = 1e-77
Identities = 241/863 (27%), Positives = 398/863 (46%), Gaps = 63/863 (7%)
Query: 1819 YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPV 1878
YF IDS+TGA+ T LD E V+ D TP A +TV V D ND PV
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSA--TTYITVLVKDTNDHSPV 352
Query: 1879 FAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTV 1938
F + Y + G +V+T+ A+D DS + L Y + G + F ++ +G ++
Sbjct: 353 FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVST 411
Query: 1939 QNTTQLR--SRYELTVRASD-----GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKEN 1991
+ + Y+L V A+D G + +V I V++ +++ +F++ Y V E+
Sbjct: 412 RAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
Query: 1992 STEAETLAVITAIGNPI--NEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047
+ + A N + Y IL N +F + SG+L P D E + +
Sbjct: 472 VGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKY 530
Query: 2048 DVVVEVTEEHKPSAV-AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAV 2106
+ ++ + +P + + VV V V D NDN P+FV+ P+ A V + +G+ + ++ AV
Sbjct: 531 SLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
Query: 2107 DRDSGRNGEVHYYLKEHHEHF----QIGP----------------LGEISLKKQFELDTL 2146
D DSG N +HY L + F GP G I++ + + + +
Sbjct: 591 DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
Query: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHV 2204
+ Y V A D G+P S+ V ITV+ N PVF +P Y + E V S V+ +
Sbjct: 651 -EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTL 709
Query: 2205 QANSPEGLKVF-YSITDGDPFSQFTINFNT--GVINVIAPLDFEAHPAYKLSIRATDSLT 2261
QA + V Y +T G+ ++F ++ G+I + PLD++ Y L++ A+D
Sbjct: 710 QARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
Query: 2262 GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQ 2321
A V ++ V D N + PVF Y V++SE +GTS+ + A D D+ N I+Y
Sbjct: 770 SHTAHVLIN--VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
Query: 2322 MFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVT 2381
+ F +D +G + + LDYE +T+ + A D G+P S + + +
Sbjct: 828 I----QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILIL 883
Query: 2382 DLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND-HKHFVI 2440
D NDN P F Y+ I E AP + V A D DS +L Y+ G+D F I
Sbjct: 884 DANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYI 943
Query: 2441 DSATGII-TLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLHSPAFLQNE 2496
+ +G+I T L R + + L+V G +S ++ VT++ N ++P F ++E
Sbjct: 944 EPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDE 1003
Query: 2497 YEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
E+ + EN P+ ++V +++ D D G + Y IV + F ++ G + + +LD
Sbjct: 1004 LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELD 1063
Query: 2556 RETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAP-----QFRATKYEVNIGSSAA 2610
E E V+ V+ + V+ TV+++L D NDN P Q Y N +S
Sbjct: 1064 FEVRREYVLVVQATSAPL---VSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
Query: 2611 KGTSVVKVLASDADEGSNADITY 2633
G + + A D D + + T+
Sbjct: 1121 TGV-IGCIPAHDPDVSDSLNYTF 1142
Score = 258 bits (659), Expect = 1e-67
Identities = 255/998 (25%), Positives = 429/998 (42%), Gaps = 127/998 (12%)
Query: 32 LQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILG 91
L+F Y V + EN A T + +++ + T E R VS E LF +E G
Sbjct: 243 LKFPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEER---VSYYMEGLF--DERSRG 294
Query: 92 DFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVE-ARTKVRVQVLDTNDLRPLFS 150
F ++L+RE K+ + L VKA++ +T A T + V V DTND P+F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYS-FKDRTDMFAIHPTSGVIVLTGR 209
+ Y + EN + + + A+D D N Y D+F ++ +SGV+
Sbjct: 355 QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
Query: 210 LDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---VTLSPSE 266
LD E Y++ + A D+G +S+ A + + +E N+ P + V P +
Sbjct: 415 LDREEAAEYQLLVEANDQGR---NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
Query: 267 LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWD 326
+ + A V D DQG N I SI++G++ QF + S G + I +D++
Sbjct: 472 VGLNTAVLRVQATDRDQGQNAAI-HYSILSGNVAGQF-YLHSLSGI----LDVINPLDFE 525
Query: 327 SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Y+L+++A+D G PP +S V+ V F ++A + E P PV
Sbjct: 526 DVQ-KYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV 584
Query: 387 VMVKAIPAYS------HLRYVFKSTP----GKA-----------KFSLNYNTGLISILEP 425
V ++A+ A S H R V ++ G A F ++ ++G I++
Sbjct: 585 VHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE 644
Query: 426 VKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480
+ R++ H+ V D +ST V + VL N N P FTQ Y+ +E+ +G+
Sbjct: 645 LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS 704
Query: 481 TVMSLSAVDPDEGENGYVTYSIA---NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLR 537
+V++L A D D N +TY + N + G ++ + LDY+ + Y L
Sbjct: 705 SVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK-QEQQYVLA 761
Query: 538 IRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD 597
+ ASD + V I + + N + P+F+ + ++ D VG I T+SA D D
Sbjct: 762 VTASDGTRSHTAHV----LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDED 817
Query: 598 ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657
+ + + + F ++P+SG + L ++ +
Sbjct: 818 TGENARITYVIQDPVPQFRIDPDSGTMYTMMEL---------------------DYENQV 856
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+T+ A + + + T + ++ + N + PQF
Sbjct: 857 AYTLTIMAQDNGIPQKSDTTTLEILILD-----------------------ANDNAPQFL 893
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKI 776
G + E+ P +S++ +++TD D+G NG+L+Y GG++ D F I+ +G+++
Sbjct: 894 WDFYQG-SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
Query: 777 LSPLDRETTDKYTLNITVYDLGIPQKAAWRL-LHVVVVDANDNPPEFLQESYFVEVSEDK 835
LDRE Y L D G P + + + V ++D NDN P F ++ + V E+
Sbjct: 953 QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
Query: 836 EVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDRELQHEHSL 893
V S + ++ A D D GPN + Y IV F +D + G + LD E++ E+ L
Sbjct: 1013 PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL 1072
Query: 894 KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT-----FIPPNYRVKVREDLPEGTVIMW 948
++A L S V + L D NDNPP + NY P G VI
Sbjct: 1073 VVQA-----TSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGC 1126
Query: 949 LEAHDPDLG--------QSGQVRYSLLDHGEGNFDVDK 978
+ AHDPD+ Q ++R LLD G + +
Sbjct: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR 1164
Score = 167 bits (424), Expect = 2e-40
Identities = 171/638 (26%), Positives = 284/638 (44%), Gaps = 73/638 (11%)
Query: 92 DFCFLRIRTKGGNT--AILNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPL 148
DF F + G T A L+RE +HY+ V+A++ + + + T V + VLD ND P+
Sbjct: 627 DFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
Query: 149 FSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPT--SGVIVL 206
F+ +Y + L E+ A+ +S+ + A D D + + + + + FA+ G+I L
Sbjct: 687 FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL 746
Query: 207 TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--VTLSP 264
LDY + + Y + + A+D G + S A + +++ AN PV + T+S
Sbjct: 747 ALPLDYKQEQQYVLAVTASD-GTR-------SHTAHVLINVTDANTHRPVFQSSHYTVSV 798
Query: 265 SELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGID 324
SE DR +I T+ D+ G+ A ++ V D + QFR + G+ ++ +D
Sbjct: 799 SE-DRPVGTSIATLSANDEDT-GENARITYVIQDPVPQFR-IDPDSGTMYTMME----LD 851
Query: 325 WDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
+++ Y LT+ A+D G P Q S + + +F D Y+ I E APP+T
Sbjct: 852 YENQ-VAYTLTIMAQDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 385 PVVMVKAIPAYS----HLRYVFKS-TPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVT 439
++ V A S L Y F+ G F + +G+I + R+ A + L
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 440 TSDR------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEG 493
DR AS ++ V +L N N P F + + +EN P+G+ V + A DPDEG
Sbjct: 970 AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 494 ENGYVTYSIA--NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREV 551
N + Y I ++ H F +D G + LD+E+ R Y L ++A+ L R V
Sbjct: 1030 PNAQIMYQIVEGDMRHF-FQLDLLNGDLRAMVELDFEVR-REYVLVVQATSAPLVSRATV 1087
Query: 552 EVLATITLNNLNDNTPLFEKI---------NCEGTIPRDLGVGEQITTVSAIDADELQLV 602
+L L + NDN P+ N + P + I + A D D +
Sbjct: 1088 HIL----LVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-----IGCIPAHDPDVSDSL 1138
Query: 603 QYQIEAGNELDFFSLNPNSGVLSLKR--------------SLMDGLGAKVSFHSLRITAT 648
Y GNEL L+P +G L L R S+ DG+ + +F +LR+T
Sbjct: 1139 NYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTII 1198
Query: 649 DGENFATPLYINITVAASHKLVN--LQCEETGVAKMLA 684
+ + + + + K ++ L GVA +L+
Sbjct: 1199 TDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLS 1236
Score = 96.7 bits (239), Expect = 5e-19
Identities = 115/477 (24%), Positives = 182/477 (38%), Gaps = 49/477 (10%)
Query: 70 VRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNV 129
+ Y++ G++ N F G L + L+ + + Y L V A + +
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGGGLITLALP--------LDYKQEQQYVLAVTASDGTRSH 771
Query: 130 EARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFK 189
A V + V D N RP+F + Y+VS+ E+ + TSIA +SA D D G N Y +
Sbjct: 772 TAH--VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 190 DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQ 249
D F I P SG + LDY Y + I+A D G+ S L + I
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-----SDTTTLEILILD 884
Query: 250 ANECAPVITAVTLSPSEL-DRDPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTV 306
AN+ AP S D P+ +I V+ D D G NG + + GD
Sbjct: 885 ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLL-YTFQGGD-------- 935
Query: 307 RSFPGSKEYKVKAIGGIDWDSHPFG------YNLTLQAKDKGTPPQFSSVKVIHVTSPQF 360
G ++ ++ G+ YNL A D+G+P S+ I VT
Sbjct: 936 ---DGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDI 992
Query: 361 KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYN 416
FEKD + E P + V ++A + + Y + F L+
Sbjct: 993 NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLL 1052
Query: 417 TGLISILEPVKRQQAAHFELEVTTSDRKASTKVLVKVL--GANSNPP-----EFTQTAYK 469
G + + + + + L V + ++ V +L N NPP + Y
Sbjct: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLD 526
+ P G + + A DPD ++ T+ N + +D TG + S +LD
Sbjct: 1113 TNKSNSFPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRL-LLLDPATGELQLSRDLD 1167
Score = 86.7 bits (213), Expect = 5e-16
Identities = 108/419 (25%), Positives = 159/419 (37%), Gaps = 54/419 (12%)
Query: 3783 KEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMT----LTGNS 3838
+EG C + C+ C G CV+ W + C CP RFG +M +G S
Sbjct: 1643 REG-CAARRNFCDGRRCQNGGTCVNR-WN-MYLCECPL-RFGGKNCEQAMPHPQLFSGES 1698
Query: 3839 YVKYRLTENENKLEMKLTMRLRTYSTHAVVMYAR--GTDYSILEIHHGRLQYKFDCG-SG 3895
V + + L + RT +V+M A G L+I + LQ++ G S
Sbjct: 1699 VVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSD 1758
Query: 3896 PGIVSVQSIQVNDGQWHAVALEVNG--------NYARLVLDQ-VHTASGTAPGTLKTLNL 3946
V + ++V DG+WH + +E+ + + LD + G L L +
Sbjct: 1759 VESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTV 1818
Query: 3947 DNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVS 4006
+ V G + R GFRGCM + + G + + + A V V
Sbjct: 1819 RSVVVGGASEDKVSVR--------RGFRGCMQGVRMGGTPTNVATLNMNNA---LKVRVK 1867
Query: 4007 PGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGT 4066
GC + C S+PC C+ + Y C C Y+G +C V+ C PC G
Sbjct: 1868 DGC--DVDDPCTSSPCPPNSRCHDA-WEDYSCVCDKGYLGINC---VDACHLNPCENMGA 1921
Query: 4067 CVVDNG---GFVCQCRGLYTGQRCQLSPYCK---DEPCKNGGTCFDSLDGAVCQCDSGFR 4120
CV G G+VC+C + G PYC+ D PC G C GF
Sbjct: 1922 CVRSPGSPQGYVCECGPSHYG------PYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFD 1975
Query: 4121 GERCQSDIDECSGNPCLHGALCENTHGSYHCNC-SHEYRGRHCEDAAPNQYVSTPWNIG 4178
+ C +C + L ++T C+C H R C D A Q P IG
Sbjct: 1976 PD-CNKTNGQCQCKENYYKLLAQDT--CLPCDCFPHGSHSRTC-DMATGQCACKPGVIG 2030
Score = 72.4 bits (176), Expect = 1e-11
Identities = 34/91 (37%), Positives = 47/91 (51%), Gaps = 4/91 (4%)
Query: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQL-- 4089
P G C+C + G +CE ++ C S PC G C GG+ C+C +TG+ C++
Sbjct: 1343 PINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDA 1402
Query: 4090 -SPYCKDEPCKNGGTCFDSLDGAV-CQCDSG 4118
S C + CKNGGTC + L G C C G
Sbjct: 1403 RSGRCANGVCKNGGTCVNLLIGGFHCVCPPG 1433
Score = 62.8 bits (151), Expect = 8e-09
Identities = 30/93 (32%), Positives = 42/93 (45%), Gaps = 22/93 (23%)
Query: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130
C EPC+N C FDS ++G C+C GF G+ C+++ID
Sbjct: 1307 CLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDL 1366
Query: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
C +PC C + G Y C C ++ G HCE
Sbjct: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCE 1399
Score = 60.5 bits (145), Expect = 4e-08
Identities = 43/152 (28%), Positives = 60/152 (39%), Gaps = 22/152 (14%)
Query: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVC 4076
C PC+N Y KC ++ + S SS L+ ++ G C
Sbjct: 1307 CLREPCEN------------YMKCVSVL---RFDSSAPFLSSTTVLFRPIHPIN--GLRC 1349
Query: 4077 QCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDI--DECSG 4133
+C +TG C+ C +PC G C G C+C F GE C+ D C+
Sbjct: 1350 RCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCAN 1409
Query: 4134 NPCLHGALCEN-THGSYHCNC-SHEYRGRHCE 4163
C +G C N G +HC C EY +CE
Sbjct: 1410 GVCKNGGTCVNLLIGGFHCVCPPGEYERPYCE 1441
Score = 43.9 bits (102), Expect = 0.004
Identities = 22/74 (29%), Positives = 30/74 (40%), Gaps = 16/74 (21%)
Query: 4122 ERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAP-------------- 4167
E C + + C G C +G C N Y C C + G++CE A P
Sbjct: 1644 EGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWS 1703
Query: 4168 --NQYVSTPWNIGL 4179
N +S PW +GL
Sbjct: 1704 DLNIIISVPWYLGL 1717
Score = 37.0 bits (84), Expect = 0.45
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 4069 VDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQ 4125
VD GF+ G G + + +C C+NGGTC + + +C+C F G+ C+
Sbjct: 1631 VDMAGFIAN-NGTREGCAARRN-FCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCE 1685
Score = 36.2 bits (82), Expect = 0.77
Identities = 45/198 (22%), Positives = 84/198 (42%), Gaps = 27/198 (13%)
Query: 38 EYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLR 97
E + V+EN+ + V ++ P ++ Y+IV GD + F+ + + GD LR
Sbjct: 1003 ELELFVEENNPVGSVVAK-IRANDPDEGPNAQIMYQIVEGDMRHFFQL-DLLNGD---LR 1057
Query: 98 IRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSP------ 151
+ L+ EV+ Y L+V+A + + +R V + ++D ND P+
Sbjct: 1058 AMVE------LDFEVRREYVLVVQA--TSAPLVSRATVHILLVDQNDNPPVLPDFQILFN 1109
Query: 152 ---TSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTG 208
T+ S S P I + A D D+ + + + + + + P +G + L+
Sbjct: 1110 NYVTNKSNSFPTGV-----IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR 1164
Query: 209 RLDYLETKLYEMEILAAD 226
LD ME+ +D
Sbjct: 1165 DLDNNRPLEALMEVSVSD 1182
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 357 bits (916), Expect = 2e-97
Identities = 362/1288 (28%), Positives = 554/1288 (43%), Gaps = 123/1288 (9%)
Query: 2286 QSYAVTLS--EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSH--DHFHVDSSTGL 2341
Q + +TLS E T V +RA ++ G + + + S D FHV TG+
Sbjct: 65 QLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
Query: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
I R LD E+ R H FV A L + V V + V D+ND+ P F + +SE
Sbjct: 125 IRTARRLDRER-RDHYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
Query: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGND------HKHFVIDSATGIITLSNLHRH 2455
+P G A+D D+ Y+++ +D F + T S L
Sbjct: 179 LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
Query: 2456 ALKPFYSLNLSVSDGVFRSSTQVH---------------------VTVIGGNLHSPAFLQ 2494
+ P L+L + + R H + V+ N + P F Q
Sbjct: 239 SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQ 298
Query: 2495 NEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI--------------VNDFAKDRF 2540
+EY + E+A V V+ TD D G G V Y + + D A F
Sbjct: 299 DEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY--F 356
Query: 2541 YINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQ---- 2595
+ E G + LDRE A + V A +VA V++ + D NDN P
Sbjct: 357 AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
Query: 2596 FRATKYEVNIGSSAAKGTSVVKVLASDAD----EGSNADITYAIEADSESVKENLEINK- 2650
F + A G V +V SDAD + A + S+ +LE +
Sbjct: 417 FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
Query: 2651 ----LSG------VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL 2700
L G + + L + + + A D GSP + + +++ Q
Sbjct: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
Query: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGT----VLYSLVKGNTP---------- 2743
P FS+ Y +VSE GT + + A + +G+ + Y++V+ + P
Sbjct: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
Query: 2744 --ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKD 2801
+ SF ID +SG + ++LD E + + ++A+ + + A+ VSI V D
Sbjct: 597 VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ-DLGEPPLSATCLVSITVDD 655
Query: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL-DQSQSVEVIESF 2860
NDN P+F Y A I E+ P G +Q+ ASDADSG G + YSL D S E ++F
Sbjct: 656 VNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
Query: 2861 AINMETGWITTLKELDHEKRD-NYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
I+ G I +++D E+ Y + V A D G LS+ A V V + DVND+ P F
Sbjct: 716 RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFN 772
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
Y ++S++ G I + TD DS I V Y + G+ F +++ +Y
Sbjct: 773 PSTYVTSISDETQPGTEIINVLATDQDSG-IYGTVAYELIPGNVSSLFTIDSTTGI--IY 829
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDV 3036
+ PL + L ++A DG T A V + + E+ Y+ + EDV
Sbjct: 830 LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
Query: 3037 LPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAVYHL 3095
I + A + + S+ I Y + G KF ++P G ++T PLD E Q V L
Sbjct: 890 PEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVL 948
Query: 3096 LVRATDGGGRFCQASIV-LTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA 3154
V+A G C ++ V +T+ DVNDN P F I + + T PGT L +A D D+
Sbjct: 949 TVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 1008
Query: 3155 GLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATG 3214
G N I YS+ G F+I+ G++ L L Q TL+L+A DQG+ + A
Sbjct: 1009 GRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ--AAL 1066
Query: 3215 TVIVSVLDINDNPP--VFEYREYGATVSEDILVGTEVLQVYAASRDIE-ANAEITYSIIS 3271
V+ V++ ++ P FE+ Y VSE + T++LQ A + A + + YS+
Sbjct: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
Query: 3272 GNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEA---TDGGTPSLSDVATVNVNVTDI 3328
+ F I TG +++ DYES+ Y V A DG ++S TV V V D
Sbjct: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS--TTVIVRVWDE 1184
Query: 3329 NDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPV 3388
NDN+P F D + E V + + + A D D N + Y ++ + G F ++P
Sbjct: 1185 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPN 1242
Query: 3389 RGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR----GN 3444
GE+ LDRE + +TV +D GSPPR T V + V+D+NDN P F +
Sbjct: 1243 TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 1302
Query: 3445 YSVIIQENKPVGFSVLQLVVTDEDSSHN 3472
V + E +PV V + D D +N
Sbjct: 1303 LHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
Score = 354 bits (909), Expect = 1e-96
Identities = 358/1266 (28%), Positives = 546/1266 (43%), Gaps = 154/1266 (12%)
Query: 765 FMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ 824
F + +TG+++ LDRE D Y+ + Q + + V D ND+ P F
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPRFPL 169
Query: 825 ESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--------FSIDSVTG- 875
+S ++VSE + A D D G Y++V +D F + T
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 876 -----------------VVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
+ + R LDRE H L+IEA D R P+ + V++ +
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR--PRRTGLLSVELRVL 287
Query: 919 DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDH---GEGN-- 973
D NDNPP F YR VRED G + + A D DLG +G VRYS+ G G+
Sbjct: 288 DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
Query: 974 --------FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
F V++LSG VR+ + LD E + + L V A+D G + +T V + V+DV
Sbjct: 348 GALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV-ATVRVSIAVLDV 406
Query: 1026 NENLHPPVFSSFVEKG---TVKEDAPVGSLVMTVSAHDED---------------ARRDG 1067
N+N P + F+ +G V E A G V VS D D DG
Sbjct: 407 NDN-RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
Query: 1068 EIRYSIRDGSGVGVFKIGEETGV--IETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEI 1125
I S+ G G G GV + LDRES Y L + ATD G PLS+ +
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 1126 YIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKIT------ 1179
+ V D+ND P S+ Y + E + V+ + A D D + +D + T
Sbjct: 526 LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
Query: 1180 ---SGNPQG----------FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKS 1226
G+ Q F+I ++G I+T R LDRE Q+ L+V D G PP S
Sbjct: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTI-RTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 1227 TIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYH----VIATDKDEG 1282
V + + D NDN+P F ++ Y + A P+ H V A+D D G
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATI-----------AEHAPVGHCFLQVTASDADSG 693
Query: 1283 PNAEISYSIEDG----NEHGKFFIEPKTGVV----SSKRFSAAGEYDILSIKAVDNGRPQ 1334
I YS+ DG F I+P G + R YD+L ++A D G
Sbjct: 694 LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAKDGGGLS 752
Query: 1335 KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-EPPGI--PLWF 1391
+ R+ +E ++ P P ++ T E+ P +I V++ + GI + +
Sbjct: 753 AQAFVRVDLEDVNDNHPVFNP----STYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808
Query: 1392 DITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVID 1448
++ GN S F +D TG I + PL + + +L V A DG T I V I +
Sbjct: 809 ELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 868
Query: 1449 TNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLD 1508
T +F KY ++ ED ++ I + A + ++ I+ SS D KF +
Sbjct: 869 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG--KFSIH 926
Query: 1509 PATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK 1568
P G++ T + LDHE LTV + P + + + V D ND+ P F +S +
Sbjct: 927 PRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDE 985
Query: 1569 GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRS 1628
R+ ++ G+ + A D+D G+N + YSI S G F ID LG + L
Sbjct: 986 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 1044
Query: 1629 NQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE--YSVELSETVSIGSFV 1686
Q E L ++A D+G P + + + + + ++ SP +T + Y VE+SE++S + +
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREH-SPSWTFEHLVYQVEVSESLSPMTQM 1103
Query: 1687 GMVTAH------SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTL-IIQG 1739
AH + S + Y ++ F I P++G I ++ D+E+ Y +
Sbjct: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
Query: 1740 TNMAGLSTN--TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAA 1797
G N TTV+V + DENDN+P F+ + ES V+ I A
Sbjct: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK-------ITAI 1216
Query: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL 1857
D D N L+Y ++ S +F ++ +TG + ++LD E TV V D G+P
Sbjct: 1217 DMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR 1274
Query: 1858 FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKG----VKVITVNATDADSSAFSQ 1913
A A V V V DIND P F + L L + +G + V TV A D D ++
Sbjct: 1275 NATMA--VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAE 1332
Query: 1914 LIYSIT 1919
+ YS++
Sbjct: 1333 VTYSVS 1338
Score = 352 bits (903), Expect = 5e-96
Identities = 356/1321 (26%), Positives = 574/1321 (43%), Gaps = 147/1321 (11%)
Query: 376 ISEFAPPNTPVVMVKA-IPAYSH-------LRYVFKSTPGKAKFSLNYNTGLISILEPVK 427
+ E PP+T V ++A +PA L +P F ++ +TG+I +
Sbjct: 73 VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
Query: 428 RQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487
R++ H+ T A +V ++V N + P F + + E P GT A
Sbjct: 133 RERRDHYSFVAATL-LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191
Query: 488 VDPDEGENGYVTYSIANLNHVP-------FAIDHFT----------GAVSTSENLDYELM 530
DPD G Y++ + +P F + + T G+ S E LD L+
Sbjct: 192 HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLL 251
Query: 531 PRV-------YTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLG 583
R+ + L+I A D G P RR + + + + NDN P+FE+ + D
Sbjct: 252 RRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQ 310
Query: 584 VGEQITTVSAIDAD--ELQLVQYQIEAGN------------ELDFFSLNPNSGVLSLKRS 629
G ++ V A D D V+Y + A + +F++ SGV+ + R
Sbjct: 311 PGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP 370
Query: 630 LMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
L A +H L + A DG A P + V+ + VN V + + +
Sbjct: 371 LDREAQA---WHQLVVEARDGG--AEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425
Query: 690 ANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGF- 748
++ G+ ++ + + G KE++ G +L G
Sbjct: 426 VSEGARPGD-------------YVARVSVSDADGDWEKEDEATG---------ELGVGLG 463
Query: 749 NGKLVYAVSGGNEDSCFMIDMETGM--LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+G + ++ GG D + G+ L + PLDRE+ D Y L + D G P +
Sbjct: 464 DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE 523
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGH--VTYSIVTD 864
L + V D ND PP F Q+ Y VSE + ++ V A+D D + H + Y++V
Sbjct: 524 TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
Query: 865 T-------------------DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEP 905
+ +F+IDS +G ++ R LDRE+Q LK+ A+D EP
Sbjct: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG--EP 641
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
L +T +V ++++DVNDN P F Y + E P G + + A D D G G + YS
Sbjct: 642 PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
Query: 966 LLD-----HGEGNFDVDKLSGAVRIVQQLDFEKKQV-YNLTVRAKDKGKPVSLSSTCYVE 1019
L D F +D G + + Q +D E+ Y+L V AKD G LS+ +V
Sbjct: 702 LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVR 758
Query: 1020 VEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGV 1079
V++ DVN+N PVF+ ++ ++ G+ ++ V A D+D+ G + Y + G+
Sbjct: 759 VDLEDVNDN--HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
Query: 1080 GVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQT 1139
+F I TG+I + L ++ L V A D G + ++ I + +
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 1140 SEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTT 1199
P Y + E+ P+D + ++A +P +SS + + Y+I+SG+ G FSIHP+ G I T
Sbjct: 877 ERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTIRTR 935
Query: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREK 1259
+ LD E Q +L V GS P + V + ++D NDN P FL+ +IR+ +
Sbjct: 936 -KPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
Query: 1260 PDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGE 1319
P LY A D+D G N I YSI + G F I+ GV+ AGE
Sbjct: 994 PGTA-------LYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGE 1045
Query: 1320 YD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMES-DPVAHM 1376
L+++A D G +++ L + + + + +FE + V ES P+ M
Sbjct: 1046 QRELTLTLRAEDQGVHPQAALLVLTV--VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
Query: 1377 IGV----ISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA- 1431
+ + + PL + + + F + TG I + + D E YN V A
Sbjct: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
Query: 1432 --TDG-TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EK 1486
DG + T V ++V D ND+ P F + + E P+ I +I+A+D D +
Sbjct: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
Query: 1487 NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFA 1546
+L+Y L S K F+++P TG L LD E H +TV+V D+ P +
Sbjct: 1224 GQLLYFLLSDG-----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
Query: 1547 RIVVNVSDTNDHAPWFT----ASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIE 1602
+ V+V+D ND+ P+F +V E V +V V A D D+G NAEV YS+
Sbjct: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
Query: 1603 S 1603
S
Sbjct: 1339 S 1339
Score = 309 bits (792), Expect = 4e-83
Identities = 324/1241 (26%), Positives = 533/1241 (42%), Gaps = 115/1241 (9%)
Query: 2438 FVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEY 2497
F + TGII + + YS V+ + + QV + V N HSP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSF---VAATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
Query: 2498 EVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV--NDFAKDR----FYINERG----- 2546
+++++E +P T D D+G++ Y +V +D KD F + R
Sbjct: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
Query: 2547 --------------QIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDN 2592
+ L +LDRE A + + + +V + + D+NDN
Sbjct: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 2593 APQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKEN------- 2645
P F +Y + A G V +V A+D D G N + Y++ A +
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
Query: 2646 ---LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPK 2702
+ +LSGV+ L + V A D G+ + + V V + +L P
Sbjct: 353 AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
Query: 2703 FSEPFYT----FTVSEDVPIGTEIDLIRA-----------EHSGTVLYSLVKGNTPES-- 2745
F T VSE G + + E +G + L G+ S
Sbjct: 413 IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
Query: 2746 --NRDESFVIDRQSGR--LKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKD 2801
D + + G L +E LD E+ Y+ ++A + + ++V D
Sbjct: 473 GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT-DAGSPPLSTEETLLLRVAD 531
Query: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLD------------ 2849
ND P+F Y+A + E G+ V+ + ASDAD +
Sbjct: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
Query: 2850 -QSQSVEVIE---SFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVD 2905
QS+ V E SFAI+ E+G I+T++ LD E ++ ++KVVA D GE LS+T +V
Sbjct: 592 LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVS 650
Query: 2906 VTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLG 2965
+TV DVND+ P F ++Y T++E P G ++ +DADS + + Y + G L
Sbjct: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG-LYGFIEYSLYDGF-LS 708
Query: 2966 QFAVETIQ---NEWKVYVKKPLDREKRD-NYLLTITATDGT-FSSKAIVEVKVLDANDNS 3020
A + + ++ ++ V + +DRE+ Y L + A DG S++A V V + D NDN
Sbjct: 709 YEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH 768
Query: 3021 PVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGEL 3079
PV + Y +I ++ PG I+ + ATD D + Y L+ G+ + F ++ TG +
Sbjct: 769 PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGII 828
Query: 3080 KTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFSADPYAITVFEN 3137
+ PL E L+V A DGGG A + + + EF Y V+E+
Sbjct: 829 YLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 888
Query: 3138 TEPGTLLTRVQATDADAGLNRKILYSLIDSAD--GQFSINELSGIIQLEKPLDRELQAVY 3195
+ + V+A + + I Y I S D G+FSI+ G I+ KPLD E Q V
Sbjct: 889 VPEDSPIGTVKAREP-LNSSEPIFYR-ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
Query: 3196 TLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAA 3255
L+++A P ++ V ++V+D+NDN P F +S+ GT + A
Sbjct: 947 VLTVQAQLGSAPA--CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
Query: 3256 SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSL 3315
RD N I YSI S + G F+ID G +F+ +L E LT+ A D G
Sbjct: 1005 DRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
Query: 3316 SDVATVNVNVTDINDNTP--VFSQDTYTTVISEDAVLEQSVITVMADDADGPSN--SHIH 3371
+ + + V V + +++P F Y +SE ++ A GP S +
Sbjct: 1064 AALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GPQRAASPLR 1121
Query: 3372 YSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA--SDNGSPPRVNTTTVNID 3429
YS+ + F I P G + + + D E+ Y V A ++G V+TT + +
Sbjct: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VR 1180
Query: 3430 VSDVNDNAPVFSRGNYSVIIQENKPVGFSVL-QLVVTDEDSSHNGPPFFFTIVTGNDEKA 3488
V D NDN+P F + ++E+ PV V+ ++ D DS NG +F + +D K
Sbjct: 1181 VWDENDNSPTFLHDVLFLKVEES-PVPQGVIGKITAIDMDSGKNGQLLYFLL---SDGKF 1236
Query: 3489 FEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYIDIRVIEES--IYPP 3543
F++NP G L+ A+ R+ + H+ + V V D G P + Y+ + I ++ +P
Sbjct: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
Query: 3544 AILPLEIFITSSGEEYSGGVIGKIHATDQDVYDT--LTYSL 3582
+ E+ + + ++ + A D D + +TYS+
Sbjct: 1297 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 309 bits (791), Expect = 5e-83
Identities = 307/1080 (28%), Positives = 482/1080 (44%), Gaps = 115/1080 (10%)
Query: 2620 ASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNG 2679
A+ EGS ++ ++D + ++ ++ +G+I T L + ++F +
Sbjct: 92 AAQQQEGSGFFLSE--DSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG- 148
Query: 2680 SPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL----- 2734
+VV V +++ P+F VSE P GT L A L
Sbjct: 149 -----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQG 203
Query: 2735 YSLVK-GNTPESNRDESFVID-RQSGRLK-----------------LEKSLDHETTKWYQ 2775
Y+LV+ + P+ F + R G L L + LD E ++
Sbjct: 204 YTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHR 263
Query: 2776 FSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASD 2835
I A + V ++V D NDN PVFE Y A + E+ G+ V ++RA+D
Sbjct: 264 LQIEA-WDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATD 322
Query: 2836 ADSGTNGQVMYSLDQSQ---------SVEVIESFAINMETGWITTLKELDHEKRDNYQIK 2886
D G NG V YS+ Q ++ FA+ +G + + LD E + +Q+
Sbjct: 323 RDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLV 382
Query: 2887 VVASDHGEKIQLSSTAIVDVTVTDVNDSPPR----FTAEIYKGTVSEDDPQGGVIAILST 2942
V A D G + +++ T V + V DVND+ P F E VSE G +A +S
Sbjct: 383 VEARDGGAEPEVA-TVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSV 441
Query: 2943 TDADSE---------EI-----NRQVTYFITGGDPLGQFAVET--IQNEWKVYVKKPLDR 2986
+DAD + E+ + ++ + GG+ G FA+ + + V+ PLDR
Sbjct: 442 SDADGDWEKEDEATGELGVGLGDGSISLSLEGGE--GDFALLPGGPPGVFFLCVEGPLDR 499
Query: 2987 EKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM 3043
E RD Y L + ATD S++ + ++V D ND P+ + Y ++ E PG ++M
Sbjct: 500 ESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVM 559
Query: 3044 QISATDADIRSN--AEITYTL--------LGSGAEK----------FKLNPDTGELKTST 3083
+SA+DAD + A + YT+ LGS K F ++ ++G + T
Sbjct: 560 WVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR 619
Query: 3084 PLDREEQAVYHLLVRATDGGGRFCQAS--IVLTLEDVNDNAPEFSADPYAITVFENTEPG 3141
LDRE Q L V A D G A+ + +T++DVNDN P F Y T+ E+ G
Sbjct: 620 TLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
Query: 3142 TLLTRVQATDADAGLNRKILYSLIDS-----ADGQFSINELSGIIQLEKPLDRELQ-AVY 3195
+V A+DAD+GL I YSL D A F I+ G I + + +DRE A Y
Sbjct: 680 HCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATY 739
Query: 3196 TLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAA 3255
L ++A D G L+A V V + D+NDN PVF Y ++S++ GTE++ V A
Sbjct: 740 DLLVEAKDGG---GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT 796
Query: 3256 SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSL 3315
+D + Y +I GN F+IDS TG +++ L + S L V A DGG +
Sbjct: 797 DQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTA 856
Query: 3316 SDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH--IHYS 3373
A V +++ F + YT ++ ED + + TV A + P NS I Y
Sbjct: 857 VINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE---PLNSSEPIFYR 913
Query: 3374 IIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDV 3433
I G+ G F+I P G ++ K LD ET LTVQA GS P ++T VNI V DV
Sbjct: 914 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDV 972
Query: 3434 NDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVN- 3492
NDN P F R + + I + P G ++ D DS NG + F ++
Sbjct: 973 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG--LIRYSIASPQPGVFAIDR 1030
Query: 3493 PQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA----ILPL 3548
GVL + ++ E+ L ++ D G ++L + + VIE+ + P+ L
Sbjct: 1031 ALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVY 1089
Query: 3549 EIFITSSGEEYSGGVIGKIHAT-DQDVYDTLTYSLDPQMDN-LFSVSSTGGKLIAHKKLD 3606
++ ++ S + + + H Q L YSL+P +D+ +F + G + ++ D
Sbjct: 1090 QVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149
Score = 284 bits (727), Expect = 1e-75
Identities = 332/1201 (27%), Positives = 508/1201 (42%), Gaps = 156/1201 (12%)
Query: 866 DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
D F + TG++ AR LDRE + +S L + V V++ + DVND+ P
Sbjct: 114 DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSP 165
Query: 926 TFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGE-------------- 971
F + ++ V E P GT AHDPD G Y+L+ +
Sbjct: 166 RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
Query: 972 ---GNFDVDKLSGA--------VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV 1020
G L G+ + ++++LD E+ + L + A D G+P + VE+
Sbjct: 226 RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVEL 284
Query: 1021 EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR------ 1074
V+D N+N PPVF + V+EDA G+ V V A D D +G +RYS+R
Sbjct: 285 RVLDENDN--PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPG 342
Query: 1075 DGSGVGV------FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128
GSG G F + E +GV+ LDRE+ + + L V A D G P + + + I
Sbjct: 343 AGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIA 402
Query: 1129 VEDVNDNAPQTSEPVYYPE-----IMENS-PKD-VSVVQIEAFDPDSSSNDKLMYKITSG 1181
V DVNDN P ++ E + E + P D V+ V + D D D+ ++ G
Sbjct: 403 VLDVNDNRP-AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVG 461
Query: 1182 NPQGFFSIHPKTG--------------LITTTSRKLDREQQDEHILEVTVTDNGSPPKST 1227
G S+ + G LDRE +D + L + TD GSPP ST
Sbjct: 462 LGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLST 521
Query: 1228 IARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDE--GPNA 1285
+++++ D ND P F Q+ YK + E P + V A+D DE +A
Sbjct: 522 EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPG-------TVVMWVSASDADEAGSDHA 574
Query: 1286 EISYSIED-------GNEHGK----------FFIEPKTGVVSSKRFSAAGEYDILSIKAV 1328
+ Y++ G+ K F I+ ++G +S+ R + + +K V
Sbjct: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
Query: 1329 --DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPG 1386
D G P S+T + I EPI F + T+ E PV H ++
Sbjct: 635 AQDLGEPPLSATCLVSI--TVDDVNDNEPI-FWRQVYNATIAEHAPVGHCFLQVTASDAD 691
Query: 1387 IPLWFDITGGNYDSH--------FDVDKGTGTIIVAKPLDAEQ-KSNYNLTVEATDGTTT 1437
L+ I YD F +D G I V++ +D E+ + Y+L VEA DG
Sbjct: 692 SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG-GG 750
Query: 1438 ILTQVFIKV--IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQS 1495
+ Q F++V D ND+ P F+ S Y I ++T P TEI+ + A DQD + + T+
Sbjct: 751 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD--SGIYGTVAY 808
Query: 1496 SRDPLSLKK-FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD---VPVKRNFARIVVN 1551
P ++ F +D TG +Y + L H + TL++MV QD + N A + ++
Sbjct: 809 ELIPGNVSSLFTIDSTTGIIYLTLPLSH--LESTTLSLMVSAQDGGGLTAVIN-ADVTIH 865
Query: 1552 VSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFM 1611
+ T F Y VYE S + V A + + + Y I SG++G F
Sbjct: 866 IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFS 924
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
I P LG+I+T K LD Q L V+A GS P T V I V ++ P F
Sbjct: 925 IHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTS 983
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKALD 1726
+ +S+T G+ + + A + S + Y I G F I+ G + +L
Sbjct: 984 DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLG 1042
Query: 1727 FETLPIYTLII----QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINS 1782
TL + QG + TV++ + E+ + F Y +SES S +
Sbjct: 1043 AGEQRELTLTLRAEDQGVHPQAALLVLTVVIE-KREHSPSWTFEHLVYQVEVSESLSPMT 1101
Query: 1783 VVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT-YFAIDSSTGAIHTVLSLDYEETS 1841
+L + PL + A A + + +EPSV + F I TG I+ DYE T
Sbjct: 1102 QMLQTQAHPLGPQRA-------ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQ 1154
Query: 1842 IFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLL----LPTYKGVK 1897
++F V + + V V V D ND P F L++ L P +GV
Sbjct: 1155 TYNFRVFAW-IPEDGFLQNVSTTVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGV- 1209
Query: 1898 VITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT--VQNTTQLRSRYELTVRAS 1955
+ + A D DS QL+Y + G+ F M+ TG L V + R +E+TV +
Sbjct: 1210 IGKITAIDMDSGKNGQLLYFLLSD--GKFFKMNPNTGELINWVALDREHRGHHEMTVLVT 1267
Query: 1956 D 1956
D
Sbjct: 1268 D 1268
Score = 283 bits (724), Expect = 3e-75
Identities = 329/1286 (25%), Positives = 526/1286 (40%), Gaps = 181/1286 (14%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
L+RE +DHY+ + L + A +V ++V D ND P F S + + E + T+
Sbjct: 131 LDRERRDHYSFVAATL-----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
Query: 168 IARVSATDADIGTNGEFYYSFKDRTDM--------FAI-HPTSGV--------------- 203
A D D G Y+ +D+ F + + T G
Sbjct: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
Query: 204 --IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261
+VL RLD E + ++I A D G + + + + + N+ PV
Sbjct: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRR-----TGLLSVELRVLDENDNPPVFEQDE 300
Query: 262 LSPS-ELDRDPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318
+ D P + V D D G NG S+ A + + + + V+
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNG-FVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
Query: 319 AIGGIDWDSHPFG------YNLTLQAKDKGTPPQFSSVKV---IHVTSPQFKAGPVKFEK 369
+ G+ P + L ++A+D G P+ ++V+V + + A V F
Sbjct: 360 ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLT 419
Query: 370 DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKST--------PGKAKFSLNYNTGLIS 421
+ A +SE A P V V A ++T G SL G +
Sbjct: 420 EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
Query: 422 ILE-------------PVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEF 463
+L P+ R+ +EL + +D +L++V N PP F
Sbjct: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
Query: 464 TQTAYKAAFDENVPIGTTVMSLSAVDPDE--GENGYVTYSIANLN-------------HV 508
+Q YKA+ E GT VM +SA D DE ++ ++ Y++ L+ H
Sbjct: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
Query: 509 -----PFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLN 563
FAID +GA+ST LD E+ V L++ A D G P L +IT++++N
Sbjct: 600 AECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQDLGEP-PLSATCLVSITVDDVN 657
Query: 564 DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAG----NELDFFSL 617
DN P+F + TI VG V+A DAD ++Y + G F +
Sbjct: 658 DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
Query: 618 NPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEET 677
+P+ G + + + + + + L + A DG + ++ +
Sbjct: 718 DPHDGQICVSQDI--DRERDPATYDLLVEAKDGGGLSAQAFVRV---------------- 759
Query: 678 GVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR-STLPTGIQVKENQPVGSSV 736
D VN + P F ST T I E QP G+ +
Sbjct: 760 ---------------------------DLEDVNDNHPVFNPSTYVTSIS-DETQP-GTEI 790
Query: 737 IFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYD 796
I + +TD D+G G + Y + GN S F ID TG++ + PL + +L ++ D
Sbjct: 791 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQD 850
Query: 797 LGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGH 856
G + + + P EF + Y V ED S I V+A + L +
Sbjct: 851 GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEP 909
Query: 857 VTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVK 914
+ Y I + FSI G + +PLD E Q L ++A Q P ST V
Sbjct: 910 IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSST-EVN 966
Query: 915 VSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNF 974
+++ DVNDN P F+ + +++ + P GT + A D D G++G +RYS+ G F
Sbjct: 967 ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVF 1026
Query: 975 DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVF 1034
+D+ G + + L +++ LT+RA+D+G V + V V++ E+ F
Sbjct: 1027 AIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTF 1084
Query: 1035 SSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGE-IRYSIRDGSGVGVFKIGEETGVIET 1093
V + V E + ++ AH +R +RYS+ +F I TG I
Sbjct: 1085 EHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL 1144
Query: 1094 SDRLDRESTSHYWLTVFATDQGVVPLSSFIE-----IYIEVEDVNDNAPQTSEPVYYPEI 1148
+ D EST Y VFA +P F++ + + V D NDN+P V + ++
Sbjct: 1145 RRQFDYESTQTYNFRVFAW----IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV 1200
Query: 1149 MENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG-LITTTSRKLDREQ 1207
E+ + +I A D DS N +L+Y + S FF ++P TG LI + LDRE
Sbjct: 1201 EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGELINWVA--LDREH 1256
Query: 1208 QDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDR--ERN 1265
+ H + V VTD GSPP++ V V + D NDN+P F+ LP +E + E
Sbjct: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP-----FFPQCLPGKELHVKVLEGQ 1311
Query: 1266 ARREPLYHVIATDKDEGPNAEISYSI 1291
+ V A D DEG NAE++YS+
Sbjct: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 282 bits (721), Expect = 6e-75
Identities = 279/996 (28%), Positives = 427/996 (42%), Gaps = 115/996 (11%)
Query: 2709 TFTVSEDVPIGTEIDLIRA--------EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL 2760
T +V E +P T + IRA E SG L ++ +S + F + +G +
Sbjct: 70 TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSE----DSDDSPLLDDFHVHPDTGII 125
Query: 2761 KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE 2820
+ + LD E Y F + A V V I+V D ND+SP F + + E
Sbjct: 126 RTARRLDRERRDHYSFVAATL-------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
Query: 2821 NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---------------------EVIES 2859
P G+ A D D+G Y+L Q + ++
Sbjct: 179 LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
+ +E + L+ LD E+ +++++ A D G + + + V++ V D ND+PP F
Sbjct: 239 SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD-GGRPRRTGLLSVELRVLDENDNPPVFE 297
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEIN--------RQVTYFITGGDPLGQ---FA 2968
+ Y+ V ED G + + TD D RQV +GG LG FA
Sbjct: 298 QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAI---VEVKVLDANDNSPVCEK 3025
VE + +V+ +PLDRE + + L + A DG + V + VLD NDN P
Sbjct: 358 VEELSGVVRVW--RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
Query: 3026 TLYSD----TIPEDVLPGKLIMQISATDA--DIRSNAEITYTL---LGSGAEKFKLNPDT 3076
++ + E PG + ++S +DA D E T L LG G+ L
Sbjct: 416 LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGE 475
Query: 3077 GE-------------LKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDN 3121
G+ L PLDRE + +Y LL+ ATD G + +++L + D+ND
Sbjct: 476 GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQ 535
Query: 3122 APEFSADPYAITVFENTEPGTLLTRVQATDAD-AGLNRKIL-YSLID------------- 3166
P FS Y +V E PGT++ V A+DAD AG + L Y+++
Sbjct: 536 PPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSK 595
Query: 3167 -----SADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL 3221
F+I+ SG I + LDRE+Q L + A D G P L+AT V ++V
Sbjct: 596 MVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVSITVD 654
Query: 3222 DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISG----NEHGK 3277
D+NDN P+F + Y AT++E VG LQV A+ D I YS+ G
Sbjct: 655 DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
Query: 3278 FSIDSKTGAVFIIENLDYESSHEYY-LTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
F ID G + + +++D E Y L VEA DGG LS A V V++ D+NDN PVF+
Sbjct: 715 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772
Query: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK 3396
TY T IS++ +I V+A D D + Y +I GN S FTID G + +T
Sbjct: 773 PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTL 832
Query: 3397 LLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVG 3456
L + +L V A D G V V I + F R Y+ ++ E+ P
Sbjct: 833 PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED 892
Query: 3457 FSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQV 3515
+ V + ++ P F+ I +G+ F ++P+ G + T + + + +L V
Sbjct: 893 SPI--GTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTV 950
Query: 3516 KVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV- 3574
+ P SS T ++I V++ + PA L I S G + A D+D
Sbjct: 951 QAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
Query: 3575 -YDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQ 3609
+ YS+ +F++ G L + L G+
Sbjct: 1010 RNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE 1045
Score = 280 bits (716), Expect = 2e-74
Identities = 311/1117 (27%), Positives = 484/1117 (43%), Gaps = 118/1117 (10%)
Query: 2242 LDFEAHPAYKLSIRATDSLTGAHAEVF-VDIIVDDINDNPPVFAQQSYAVTLSEASVIGT 2300
LD E A++L I A D + V++ V D NDNPPVF Q Y + E + G
Sbjct: 254 LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGA 313
Query: 2301 SVVQVRATDSDSEPNRGISYQMF----------GNHSKSHDHFHVDSSTGLISLLRTLDY 2350
V +VRATD D PN + Y + G +F V+ +G++ + R LD
Sbjct: 314 EVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDR 373
Query: 2351 EQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPP----LFEQQIYEARISEHAPHG 2406
E H + V A DGG + V V++ V D+NDN P LF + AR+SE A G
Sbjct: 374 EAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPG 433
Query: 2407 HFVTCVKAYDADSSDIDK----------------LQYSILSGNDHKHFVIDSATGIITL- 2449
+V V DAD D +K + S+ G + G+ L
Sbjct: 434 DYVARVSVSDADG-DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLC 492
Query: 2450 --SNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHS--PAFLQNEYEVELAENA 2505
L R + + L ++ G ST+ + + +L+ P F Q Y+ ++E A
Sbjct: 493 VEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAA 552
Query: 2506 PLHTLVMEVKTTDGDSGIYGH--VTYHIVN----------------------DFAKDRFY 2541
T+VM V +D D H + Y +V FA D
Sbjct: 553 APGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAID--- 609
Query: 2542 INERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV--AFCTVNVILTDDNDNAPQFRAT 2599
+E G I T+ LDRE ++ + ++++A+D G A C V++ + D NDN P F
Sbjct: 610 -SESGAISTIRTLDREV--QEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
Query: 2600 KYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD--SESVKENLEINKLSGVITT 2657
Y I A G ++V ASDAD G I Y++ S + I+ G I
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
Query: 2658 KESLIGLENEFFTF--FVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSED 2715
+ I E + T+ V A D G S ++ V V ++ + P F+ Y ++S++
Sbjct: 727 SQD-IDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH--PVFNPSTYVTSISDE 783
Query: 2716 VPIGTEIDLIRAEHS-----GTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHET 2770
GTEI + A GTV Y L+ GN F ID +G + L L H
Sbjct: 784 TQPGTEIINVLATDQDSGIYGTVAYELIPGNV-----SSLFTIDSTTGIIYLTLPLSHLE 838
Query: 2771 TKWYQFSILARCTQDDHEMVASV--DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRV 2828
+ + A QD + A + DV+I + FE Y + E++P S +
Sbjct: 839 STTLSLMVSA---QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI 895
Query: 2829 IQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVV 2888
++A + + + + Y + S ++ F+I+ G I T K LDHE + + V
Sbjct: 896 GTVKAREPLNSSE-PIFYRIS---SGDLGGKFSIHPRLGTIRTRKPLDHETQP-VVVLTV 950
Query: 2889 ASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSE 2948
+ G SST V++TV DVND+ P F + +S+ P G + + D DS
Sbjct: 951 QAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
Query: 2949 EINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKA- 3007
N + Y I P G FA++ +++ L ++ LT+ A D +A
Sbjct: 1010 R-NGLIRYSIASPQP-GVFAIDRALGV--LFLNGSLGAGEQRELTLTLRAEDQGVHPQAA 1065
Query: 3008 -IVEVKVLDANDNSP--VCEKTLYSDTIPEDVLPGKLIMQISATD-ADIRSNAEITYTLL 3063
+V V++ ++SP E +Y + E + P ++Q A R+ + + Y+L
Sbjct: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 1125
Query: 3064 GS-GAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRA---TDGGGRFCQASIVLTLEDVN 3119
S + F + P TG + D E Y+ V A DG + ++++ + D N
Sbjct: 1126 PSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEN 1185
Query: 3120 DNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQF-SINELS 3178
DN+P F D + V E+ P ++ ++ A D D+G N ++LY L+ +DG+F +N +
Sbjct: 1186 DNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNT 1243
Query: 3179 GIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEY----RE 3234
G + LDRE + + +++ D+G P R AT V VSV DINDN P F +E
Sbjct: 1244 GELINWVALDREHRGHHEMTVLVTDRGSPPR-NATMAVYVSVTDINDNRPFFPQCLPGKE 1302
Query: 3235 YGATVSEDILVGTEVLQVYAASRDIEANAEITYSIIS 3271
V E V V V+A D NAE+TYS+ S
Sbjct: 1303 LHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 279 bits (714), Expect = 4e-74
Identities = 319/1134 (28%), Positives = 488/1134 (43%), Gaps = 108/1134 (9%)
Query: 2040 DREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHV 2099
DRE+ A + +E + +P + V++ V D+NDN PVF Y A V+ D + G
Sbjct: 255 DREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAE 314
Query: 2100 IRYVTAVDRDSGRNGEVHYYLKEHH---EHFQIGPLGEISLKKQFELD-------TLNKE 2149
+ V A DRD G NG V Y ++ G LG+ + EL L++E
Sbjct: 315 VCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDRE 374
Query: 2150 ----YLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYS----AEIAESIQVHS 2199
+ + V A+DGG A V V I V+ N P F + A ++E +
Sbjct: 375 AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGD 434
Query: 2200 PVVHVQANSPEGL------------------KVFYSITDGDPFSQFTINFNTGV--INVI 2239
V V + +G + S+ G+ GV + V
Sbjct: 435 YVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVE 494
Query: 2240 APLDFEAHPAYKLSIRATDSLTGA-HAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298
PLD E+ Y+L + ATD+ + E + + V D+ND PP+F+QQ Y ++SEA+
Sbjct: 495 GPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAP 554
Query: 2299 GTSVVQVRATDSD----------------SEP-NRGISYQMFGNHSKSHDHFHVDSSTGL 2341
GT V+ V A+D+D S P N G + ++ F +DS +G
Sbjct: 555 GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA 614
Query: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
IS +RTLD E + V A D G P LS+ +V++ V D+NDN P+F +Q+Y A I+E
Sbjct: 615 ISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAE 674
Query: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSI----LSGNDHKHFVIDSATGIITLS-NLHRHA 2456
HAP GH V A DADS ++YS+ LS + F ID G I +S ++ R
Sbjct: 675 HAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER 734
Query: 2457 LKPFYSLNLSVSDGVFRSSTQ-VHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVK 2515
Y L + DG S+ V V + N + P F + Y +++ T ++ V
Sbjct: 735 DPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL 794
Query: 2516 TTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGG 2575
TD DSGIYG V Y ++ F I+ I L L +S+ + A+D GG
Sbjct: 795 ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL-TLPLSHLESTTLSLMVSAQDGGG 853
Query: 2576 KVAFCTVNV-ILTDDNDNAP-QFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITY 2633
A +V I AP +F KY + + + + V A + S+ I Y
Sbjct: 854 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFY 912
Query: 2634 AIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKI 2693
I S + I+ G I T++ L V+A +P+ S V + +
Sbjct: 913 RI--SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITV 969
Query: 2694 LPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLYSLVKGNTPESNRD 2748
+ P F +S+ P GT + L RAE +G + YS+ S +
Sbjct: 970 MDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA------SPQP 1023
Query: 2749 ESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSP- 2807
F IDR G L L SL + ++ A Q H A + +++ V + ++SP
Sbjct: 1024 GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE-DQGVHPQAALLVLTV-VIEKREHSPS 1081
Query: 2808 -VFESSPYEAFIVENLPGGSRVIQIRASD-ADSGTNGQVMYSLDQSQSVEVIESFAINME 2865
FE Y+ + E+L ++++Q +A + YSL+ S + F I
Sbjct: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM---FGIRPY 1138
Query: 2866 TGWITTLKELDHEKRDNYQIKVVA--SDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIY 2923
TGWI ++ D+E Y +V A + G +S+T I V V D ND+ P F ++
Sbjct: 1139 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI--VRVWDENDNSPTFLHDVL 1196
Query: 2924 KGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKP 2983
V E GVI ++ D DS + N Q+ YF+ G+F + N ++
Sbjct: 1197 FLKVEESPVPQGVIGKITAIDMDSGK-NGQLLYFLLSD---GKF-FKMNPNTGELINWVA 1251
Query: 2984 LDREKRDNYLLTITATD---GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGK 3040
LDRE R ++ +T+ TD ++ V V V D NDN P + L + VL G+
Sbjct: 1252 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311
Query: 3041 ----LIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQ 3090
L+ + A D D +NAE+TY++ S A L T K S +Q
Sbjct: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV--SSARPMPLKGKTAFGKQSCKKQTNKQ 1363
Score = 277 bits (708), Expect = 2e-73
Identities = 302/1132 (26%), Positives = 489/1132 (43%), Gaps = 154/1132 (13%)
Query: 135 VRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDR--- 191
V ++VLD ND P+F Y ++ E+ + RV ATD D+G NG YS + R
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
Query: 192 -----------TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM 240
FA+ SGV+ + LD +++ + A D G + ++ S+
Sbjct: 342 GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSI 401
Query: 241 AKLTVHIEQANECAPVITAVTLSP------SELDRDPAY-AIVTVDDCD------QGANG 287
A L V N+ P I + L+ SE R Y A V+V D D A G
Sbjct: 402 AVLDV-----NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
Query: 288 DIA--------SLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAK 339
++ SLS+ G+ F + P + + G +D +S Y L L A
Sbjct: 457 ELGVGLGDGSISLSLEGGE--GDFALLPGGPPG-VFFLCVEGPLDRESRDL-YELLLVAT 512
Query: 340 DKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----- 394
D G+PP S+ + + + P F + Y+A +SE A P T V+ V A A
Sbjct: 513 DAGSPP-LSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGS 571
Query: 395 -YSHLRY--VFKSTPGK---------------AKFSLNYNTGLISILEPVKRQQAAHFEL 436
++ LRY V S P F+++ +G IS + + R+ EL
Sbjct: 572 DHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVEL 631
Query: 437 EVTTSD-----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD 491
+V D A+ V + V N N P F + Y A E+ P+G + ++A D D
Sbjct: 632 KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
Query: 492 EGENGYVTYSIAN--LNH---VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
G G++ YS+ + L++ F ID G + S+++D E P Y L + A D G
Sbjct: 692 SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-- 749
Query: 547 YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQY 604
+ + L ++NDN P+F +I + G +I V A D D V Y
Sbjct: 750 -GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808
Query: 605 QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664
++ GN F+++ +G++ L L + + SL ++A DG + ++T+
Sbjct: 809 ELIPGNVSSLFTIDSTTGIIYLTLPLSH---LESTTLSLMVSAQDGGGLTAVINADVTI- 864
Query: 665 ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724
+T +A E+ ++ ED+ DS P G
Sbjct: 865 --------HIFQTTLAPAEFERPKYTFLVY-----EDVPEDS--------------PIG- 896
Query: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET 784
VK +P+ SS + Y +S G+ F I G ++ PLD ET
Sbjct: 897 TVKAREPLNSS--------------EPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
Query: 785 TDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQV 844
L + LG + +++ V+D NDN P FL+ S + +S+ + +
Sbjct: 943 QPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
Query: 845 EATDKDLGPNGHVTYSIVT-DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903
A D+D G NG + YSI + F+ID GV+ + L Q E +L + A DQ
Sbjct: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-V 1060
Query: 904 EPQLFSTVVVKVSLEDVNDNPP-TFIPPNYRVKVREDLPEGTVIMWLEAHDPDLG---QS 959
PQ + +V+ V +E +P TF Y+V+V E L T ++ +AH LG +
Sbjct: 1061 HPQA-ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--PLGPQRAA 1117
Query: 960 GQVRYSLLDH-GEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA--KDKGKPVSLSSTC 1016
+RYSL F + +G + + +Q D+E Q YN V A + G ++S+T
Sbjct: 1118 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 1176
Query: 1017 YVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRY-SIRD 1075
V V V D N+N P F V V+E ++ ++A D D+ ++G++ Y + D
Sbjct: 1177 -VIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
G FK+ TG + LDRE H+ +TV TD+G P ++ + +Y+ V D+NDN
Sbjct: 1234 GK---FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
Query: 1136 APQTSEPV----YYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNP 1183
P + + + +++E P ++ V + A DPD +N ++ Y ++S P
Sbjct: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
Score = 275 bits (704), Expect = 6e-73
Identities = 326/1299 (25%), Positives = 535/1299 (41%), Gaps = 162/1299 (12%)
Query: 1465 IPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEA 1524
+P DT + A Q E + + S PL L F + P TG + T+ +LD E
Sbjct: 77 LPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPL-LDDFHVHPDTGIIRTARRLDRER 135
Query: 1525 VHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQV 1584
++ V ++ + V+D NDH+P F S + V E + G+
Sbjct: 136 RDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLP 189
Query: 1585 TALDKDKGKNAEVLYSIESGNI--------------------------GNSFMIDPVLGS 1618
A D D G + Y++ + G+S ++P+
Sbjct: 190 VAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL--D 247
Query: 1619 IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSE 1678
+ + LDR A + L ++A D G P + + SV + V ++ P F EY + E
Sbjct: 248 LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
Query: 1679 TVSIGSFVGMVTAHSQSS-----VVYEIK----------DGNTGDA--FDINPHSGTIIT 1721
G+ V V A + V Y ++ G GDA F + SG +
Sbjct: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
Query: 1722 QKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQ--DENDNAP----VFMQAEYTGLIS 1775
+ LD E + L+++ + TV V + D NDN P +F+ +S
Sbjct: 368 WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
Query: 1776 ESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS- 1834
E A V + +DAD D E + G+I L
Sbjct: 428 EGARPGDYVAR-------VSVSDADGDWEK-------EDEATGELGVGLGDGSISLSLEG 473
Query: 1835 -----------------------LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVID 1871
LD E ++ + D G+P L E + + V D
Sbjct: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE--ETLLLRVAD 531
Query: 1872 INDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADS--SAFSQLIYSITE--------- 1920
+ND PP+F++ Y+AS+ G V+ V+A+DAD S + L Y++ +
Sbjct: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
Query: 1921 --------GNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASDGRFAGLTS---VKI 1967
G F++D ++GA++ T +++ EL V A D L++ V I
Sbjct: 592 LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
Query: 1968 NVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA------IGNPINEPLFYHILNPD- 2020
V + ++ F + VY+A + E++ +TA + I L+ L+ +
Sbjct: 652 TVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
Query: 2021 -RRFKISRTSGVLSTTGTPFDREQQEA-FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNA 2078
+ F+I G + + DRE+ A +D++VE + SA A V +V +ED NDN
Sbjct: 712 PQAFRIDPHDGQICVS-QDIDRERDPATYDLLVEAKDGGGLSAQAFV--RVDLEDVNDNH 768
Query: 2079 PVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLK 2138
PVF Y + +T+ G I V A D+DSG G V Y L + + L I
Sbjct: 769 PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN----VSSLFTIDST 824
Query: 2139 KQFELDTLNKEYL------VTVVAKDGGN--PAFSAEVIVPITVMNKAMPVFEKPFYSAE 2190
TL +L + V A+DGG +A+V + I A FE+P Y+
Sbjct: 825 TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
Query: 2191 IAESIQVHSPVVHVQANSP--EGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHP 2248
+ E + SP+ V+A P +FY I+ GD +F+I+ G I PLD E P
Sbjct: 885 VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
Query: 2249 AYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRAT 2308
L+++A A + V+I V D+NDN P F + S + +S+ + GT++ RA
Sbjct: 945 VVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
Query: 2309 DSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP 2368
D DS N I Y + S F +D + G++ L +L + R+ T+ +RA D G+
Sbjct: 1005 DRDSGRNGLIRYSI---ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
Query: 2369 TLSSDVIVTVDVTDLNDNPP-LFEQQIYEARISEH-APHGHFVTCVKAYDADSSDIDKLQ 2426
++ +++TV + +P FE +Y+ +SE +P + L+
Sbjct: 1062 PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 1121
Query: 2427 YSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSV---SDGVFRS-STQVHVTV 2482
YS+ D F I TG I L + Y+ + DG ++ ST V V V
Sbjct: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV 1181
Query: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542
N +SP FL + +++ E+ ++ ++ D DSG G + Y +++D +
Sbjct: 1182 WDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP 1241
Query: 2543 NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQF----RA 2598
N G++ LDRE ++V + + + + A V V +TD NDN P F
Sbjct: 1242 N-TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 2599 TKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA 2637
+ V + V V A D DEG+NA++TY++ +
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 267 bits (683), Expect = 2e-70
Identities = 329/1256 (26%), Positives = 538/1256 (42%), Gaps = 160/1256 (12%)
Query: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKY 1461
F V TG I A+ LD E++ +Y+ G + QV I+V D NDH P+F
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA---VVQVEIRVNDVNDHSPRFPLDSL 172
Query: 1462 EVVIPEDTAPETEILQISAVDQDEK--NKLIYTLQSSRD-------PLSLKKFR------ 1506
++ + E + P T A D D + YTL D P ++R
Sbjct: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
Query: 1507 --LDPATGS------LYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDH 1558
L P + S L +LD E H L + D P + + + V D ND+
Sbjct: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES----------GNIGN 1608
P F Y+ V E A G+ V +V A D+D G N V YS+ + G +G+
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
Query: 1609 S--FMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
+ F ++ + G ++ + LDR QA + L+V+A D G+ P E+ +VR+ + + D +
Sbjct: 353 AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP--EVATVRVSIAVLDVNDNR 410
Query: 1667 ------FTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGD--------AFDI 1712
F ++ +SE G +V V+ S + +E +D TG+ + +
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSV-SDADGDWEKEDEATGELGVGLGDGSISL 469
Query: 1713 NPHSGT---------------IITQKALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHL 1755
+ G + + LD E+ +Y L++ T+ LST T+L+ +
Sbjct: 470 SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRV 529
Query: 1756 QDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK--DSNALLVYHIVE 1813
D ND P+F Q Y +SE+A+ +VV+ + A+DAD+ +A L Y +V+
Sbjct: 530 ADLNDQPPLFSQQHYKASVSEAAAPGTVVMW-------VSASDADEAGSDHAWLRYTVVQ 582
Query: 1814 PS------------VHTY-----FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
S VHT FAIDS +GAI T+ +LD E V D+G P
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIY 1916
L A ++TV D+ND P+F + +Y A++ G + V A+DADS + + Y
Sbjct: 643 LSATCLVSITVD--DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
Query: 1917 SITEGNIG----EKFSMDYKTGALTVQNTTQLR---SRYELTVRASDGRFAGLTS---VK 1966
S+ +G + + F +D G + V + Y+L V A DG GL++ V+
Sbjct: 701 SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFVR 758
Query: 1967 INVKESKESHLKFTQDVY-SAVVKENSTEAETLAVI-TAIGNPINEPLFYHIL--NPDRR 2022
+++++ ++H F Y +++ E E + V+ T + I + Y ++ N
Sbjct: 759 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
Query: 2023 FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFV 2082
F I T+G++ T P + ++V + +AV + V + + Q AP
Sbjct: 819 FTIDSTTGIIYLT-LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI-FQTTLAPAEF 876
Query: 2083 NLPYYAV-----VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE---HFQIGP-LG 2133
P Y V D+ +G T R+ + E +Y + F I P LG
Sbjct: 877 ERPKYTFLVYEDVPEDSPIG------TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
Query: 2134 EISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA-EVIVPITVMNKAMPVFEKPFYSAEIA 2192
I +K + +T ++TV A+ G PA S+ EV + + +N P F + I+
Sbjct: 931 TIRTRKPLDHET-QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 989
Query: 2193 ESIQVHSPVVHVQANSPEGLK---VFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPA 2249
++ + + +A + + + YSI P F I+ GV+ + L
Sbjct: 990 QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRE 1048
Query: 2250 YKLSIRATDSLTGAHAEVFVDIIVDDINDNPP--VFAQQSYAVTLSEASVIGTSVVQVRA 2307
L++RA D A + V +V + ++ P F Y V +SE+ T ++Q +A
Sbjct: 1049 LTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
Query: 2308 TDSDSEPNRGISYQMFG-NHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRA---V 2363
P R S + S F + TG I L R DYE ++ + V A
Sbjct: 1109 --HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
Query: 2364 DGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDID 2423
DG + +S+ VIV V D NDN P F + ++ E + + A D DS
Sbjct: 1167 DGFLQNVSTTVIVR--VWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
Query: 2424 KLQYSILSGNDHKHFVIDSATG-IITLSNLHRHALKPFYSLNLSVSD--GVFRSSTQ-VH 2479
+L Y +LS D K F ++ TG +I L R + + + + V+D R++T V+
Sbjct: 1225 QLLYFLLS--DGKFFKMNPNTGELINWVALDREH-RGHHEMTVLVTDRGSPPRNATMAVY 1281
Query: 2480 VTVIGGNLHSPAFLQ----NEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI 2531
V+V N + P F Q E V++ E P++ LV V D D G VTY +
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 265 bits (678), Expect = 6e-70
Identities = 326/1231 (26%), Positives = 495/1231 (40%), Gaps = 143/1231 (11%)
Query: 366 KFEKDVYRAEISEFAPPNT----PVVMVKAIPAYSHLRYVF------KSTPGKAKFSLNY 415
+F D + ++SE +PP T PV +S Y P F L Y
Sbjct: 166 RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
Query: 416 NT----------GLISILEPVK--------RQQAAHFELEVTTSD-----RKASTKVLVK 452
T G S LEP+ R++AA L++ D R V ++
Sbjct: 226 RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
Query: 453 VLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--- 509
VL N NPP F Q Y+AA E+ G V + A D D G NG+V YS+ VP
Sbjct: 286 VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV-RARQVPGAG 344
Query: 510 -----------FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT 558
FA++ +G V LD E + L + A D G V +I
Sbjct: 345 SGGGALGDAAYFAVEELSGVVRVWRPLDREAQAW-HQLVVEARDGGAE-PEVATVRVSIA 402
Query: 559 LNNLNDNTPLFEKINC-EGTIPR---DLGVGEQITTVSAIDADELQLVQYQIEAGNELDF 614
+ ++NDN P + EG + R G+ + VS DAD + + EA EL
Sbjct: 403 VLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDW--EKEDEATGELGV 460
Query: 615 FSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLYINITVAASHKLVNL 672
L S LSL+ D + +G + + LY + VA L
Sbjct: 461 -GLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRS--TLPTGIQVKENQ 730
EET LL+ L++Q + F A + + + T+ + +
Sbjct: 520 STEET--------LLLRVADLNDQPPL----FSQQHYKASVSEAAAPGTVVMWVSASDAD 567
Query: 731 PVGSSVIFMNSTDLDTG-------FNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRE 783
GS ++ T + K+V+ G F ID E+G + + LDRE
Sbjct: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDRE 624
Query: 784 TTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQ 843
+ L + DLG P +A L+ + V D NDN P F ++ Y ++E V +Q
Sbjct: 625 VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQ 684
Query: 844 VEATDKDLGPNGHVTYSIVTD------TDTFSIDSVTGVVNIARPLDRELQ-HEHSLKIE 896
V A+D D G G + YS+ F ID G + +++ +DRE + L +E
Sbjct: 685 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 744
Query: 897 ARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL 956
A+D Q F V+V LEDVNDN P F P Y + ++ GT I+ + A D D
Sbjct: 745 AKDGGGLSAQAF----VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDS 800
Query: 957 GQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSST 1015
G G V Y L+ + F +D +G + + L + +L V A+D G L++
Sbjct: 801 GIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAV 857
Query: 1016 CYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD 1075
+V + L P F V ED P S + TV A E I Y I
Sbjct: 858 INADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISS 916
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
G G F I G I T LD E+ LTV A G P S E+ I V DVNDN
Sbjct: 917 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 975
Query: 1136 AP---QTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPK 1192
P +TS+ + I + +P ++ A D DS N + Y I S P G F+I
Sbjct: 976 HPAFLRTSDEI---RISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 1031
Query: 1193 TGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQ--FLQKFY 1250
G++ L +Q E L + D G P++ + V+ ++++ ++ P F Y
Sbjct: 1032 LGVLFLNG-SLGAGEQRELTLTLRAEDQGVHPQAALL-VLTVVIEKREHSPSWTFEHLVY 1089
Query: 1251 KIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS 1310
++ + E P + H + + P + YS+E + F I P TG +
Sbjct: 1090 QVEVSESLSP---MTQMLQTQAHPLGPQRAASP---LRYSLEPSVDSAMFGIRPYTGWIY 1143
Query: 1311 SKR---FSAAGEYDILSIKAV-DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFT 1366
+R + + Y+ + ++G Q STT + W +F
Sbjct: 1144 LRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSP----TFLHDVLFLK 1199
Query: 1367 VMESDPVAHMIGVISV-----EPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQ 1421
V ES +IG I+ G L+F ++ G + F ++ TG +I LD E
Sbjct: 1200 VEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGELINWVALDREH 1256
Query: 1422 KSNYNLTVEATDGTT---TILTQVFIKVIDTNDHRPQFST----SKYEVVIPEDTAPETE 1474
+ ++ +TV TD + V++ V D ND+RP F + V + E
Sbjct: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
Query: 1475 ILQISAVDQDEKN--KLIYTLQSSRDPLSLK 1503
+ + A D DE N ++ Y++ S+R P+ LK
Sbjct: 1317 VTTVFAKDPDEGNNAEVTYSVSSAR-PMPLK 1346
Score = 239 bits (610), Expect = 5e-62
Identities = 318/1264 (25%), Positives = 524/1264 (41%), Gaps = 155/1264 (12%)
Query: 1708 DAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVF-- 1765
D F ++P +G I T + LD E Y+ + L V + + D ND++P F
Sbjct: 114 DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL----LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 1766 --MQAEYTGLISESASINSVVLTDRNVPL-------VIRAADADKDSNA---LLVYHIVE 1813
+Q + + L + V D + L +++ +D KD L Y
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 1814 PSVHTYFAIDSST-GAIHTVL--SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
P SS + VL LD EE + ++ D G PR +V + V+
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG--LLSVELRVL 287
Query: 1871 DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE---------- 1920
D ND PPVF + Y A++ G +V V ATD D + YS+
Sbjct: 288 DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
Query: 1921 GNIGEK--FSMDYKTGALTVQNTTQLRSR--YELTVRASDGRF---AGLTSVKINVKESK 1973
G +G+ F+++ +G + V ++ ++L V A DG V I V +
Sbjct: 348 GALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
Query: 1974 ES----HLKFTQDVYSAVVKENSTEAETLAVIT---AIGNPINEPLFYHILNP---DRRF 2023
++ H+ F + A V E + + +A ++ A G+ E L D
Sbjct: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
Query: 2024 KISRTSG---------------VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVK 2068
+S G L G P DRE ++ +++++ T+ P +
Sbjct: 468 SLSLEGGEGDFALLPGGPPGVFFLCVEG-PLDRESRDLYELLLVATDAGSPPLSTEETLL 526
Query: 2069 VIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQ 2128
+ V D ND P+F Y A V G V+ +V+A D D G H +L+ + Q
Sbjct: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEA--GSDHAWLR--YTVVQ 582
Query: 2129 IGP---LGEISLK--------KQFELD----------TLNKEYL----VTVVAKDGGNPA 2163
+ LG + K F +D TL++E + VVA+D G P
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
Query: 2164 FSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPVVH-----VQANSPEGLKVF- 2215
SA +V ITV +N P+F + Y+A IAE H+PV H +++ GL F
Sbjct: 643 LSATCLVSITVDDVNDNEPIFWRQVYNATIAE----HAPVGHCFLQVTASDADSGLYGFI 698
Query: 2216 -YSITDG----DPFSQFTINFNTGVINVIAPLDFEAHPA-YKLSIRATDSLTGAHAEVFV 2269
YS+ DG + F I+ + G I V +D E PA Y L + A D G A+ FV
Sbjct: 699 EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG-GGLSAQAFV 757
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
+ ++D+NDN PVF +Y ++S+ + GT ++ V ATD DS ++Y++ + S
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +DS+TG+I L L + +S ++ V A DGG T + VT+ + P
Sbjct: 818 --LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
FE+ Y + E P + VKA + +S + + Y I SG+ F I G I
Sbjct: 876 FERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTIRT 934
Query: 2450 SNLHRHALKPFYSLNLSVSDGVFR--SSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPL 2507
H +P L + G SST+V++TV+ N + PAFL+ E+ +++ P
Sbjct: 935 RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
Query: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVND----FAKDRFYINERGQIFTLEKLDRETPAEKV 2563
T + + D DSG G + Y I + FA DR G +F L E
Sbjct: 995 GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDR----ALGVLFLNGSLGAGEQRELT 1050
Query: 2564 ISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQ--FRATKYEVNIGSSAAKGTSVVKVLAS 2621
+++R + + A + V++ + +++P F Y+V + S + T +++ A
Sbjct: 1051 LTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
Query: 2622 D-ADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF--FVRAVDN 2678
+ + + + Y++E +S I +G I + + + F F ++
Sbjct: 1110 PLGPQRAASPLRYSLEPSVDSAM--FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSED-VPIG-----TEIDLIRAEHSGT 2732
G S ++ V++ P F V E VP G T ID+ + +G
Sbjct: 1168 GFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGK-NGQ 1225
Query: 2733 VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVAS 2792
+LY L+ + F ++ +G L +LD E ++ ++L + A+
Sbjct: 1226 LLYFLLSDG-------KFFKMNPNTGELINWVALDREHRGHHEMTVLV-TDRGSPPRNAT 1277
Query: 2793 VDVSIQVKDANDNSPVF----ESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL 2848
+ V + V D NDN P F ++E P V + A D D G N +V YS+
Sbjct: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Query: 2849 DQSQ 2852
++
Sbjct: 1338 SSAR 1341
Score = 187 bits (475), Expect = 2e-46
Identities = 267/1057 (25%), Positives = 429/1057 (40%), Gaps = 142/1057 (13%)
Query: 90 LGDFCFLRIRTKGGNTAI---LNREVKDHYTLIVKALEKNTNVEART-KVRVQVLDTNDL 145
LGD + + G + L+RE + + L+V+A + E T +V + VLD ND
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
Query: 146 RP----LFSPTSYSVSLPENTAIRTSIARVSATDAD------------IGT---NGEFYY 186
RP LF + E +ARVS +DAD +G +G
Sbjct: 410 RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
Query: 187 SFKDRTDMFAIHP--TSGVIVL--TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAK 242
S + FA+ P GV L G LD LYE+ ++A D GS +S+
Sbjct: 470 SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA-----GSPPLSTEET 524
Query: 243 LTVHIEQANE-----------------CAPVITAVTLSPSELDR---DPAYAIVTVDDCD 282
L + + N+ AP + +S S+ D D A+ TV
Sbjct: 525 LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 283 QGAN-GDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK 341
N G + S + + F S+ + I +D + L + A+D
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAI-----DSESGAISTIRTLDREVQE-AVELKVVAQDL 638
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSH 397
G PP S+ ++ +T F + VY A I+E AP + V A A Y
Sbjct: 639 GEPP-LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGF 697
Query: 398 LRYV----FKSTPGKAKFSLNYNTGLISILEPVKRQQ-AAHFELEVTTSD---RKASTKV 449
+ Y F S F ++ + G I + + + R++ A ++L V D A V
Sbjct: 698 IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFV 757
Query: 450 LVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI--ANLNH 507
V + N N P F + Y + + GT ++++ A D D G G V Y + N++
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
Query: 508 VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTP 567
+ F ID TG + + L + L +L + A D G + TI +
Sbjct: 818 L-FTIDSTTGIIYLTLPLSH-LESTTLSLMVSAQDGG-GLTAVINADVTIHIFQTTLAPA 874
Query: 568 LFEKINCEGTIPRDLGVGEQITTVSAID-ADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626
FE+ + D+ I TV A + + + + Y+I +G+ FS++P G +
Sbjct: 875 EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
Query: 627 KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEK 686
++ L + T + +TV A
Sbjct: 935 RKPL---------------------DHETQPVVVLTVQAQ-------------------- 953
Query: 687 LLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT 746
L + + EV D VN + P F T I++ + P G+++ + D D+
Sbjct: 954 -LGSAPACSSTEVNITVMD---VNDNHPAFLRT-SDEIRISQTTPPGTALYLARAEDRDS 1008
Query: 747 GFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
G NG + Y+++ + F ID G+L + L + TL + D G+ +AA
Sbjct: 1009 GRNGLIRYSIA-SPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 1067
Query: 807 LLHVVVVDANDNPPEFLQES--YFVEVSEDKEVHSEIIQVEATDKDLGPN---GHVTYSI 861
+L VV++ ++ P + E Y VEVSE ++++Q +A LGP + YS+
Sbjct: 1068 VL-TVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSL 1124
Query: 862 VTDTDT--FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLED 919
D+ F I TG + + R D E ++ ++ A Q ST V+ V + D
Sbjct: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWD 1183
Query: 920 VNDNPPTFIPPNYRVKVRED-LPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978
NDN PTF+ +KV E +P+G VI + A D D G++GQ+ Y LL G+ F ++
Sbjct: 1184 ENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGK-FFKMNP 1241
Query: 979 LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNEN--LHPPVFSS 1036
+G + LD E + + +TV D+G P ++T V V V D+N+N P
Sbjct: 1242 NTGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 1037 FVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI 1073
V E PV LV TV A D D + E+ YS+
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 81.6 bits (200), Expect = 2e-14
Identities = 133/578 (23%), Positives = 222/578 (38%), Gaps = 90/578 (15%)
Query: 60 GVYITHPAWEVRYKIVSGDSENLFKAEE-----YILGDFCFLRIRTK---------GGNT 105
G+Y T V Y+++ G+ +LF + Y+ L T GG T
Sbjct: 801 GIYGT-----VAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLT 855
Query: 106 AILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
A++N +V H + + T A + RP ++ Y +PE++ I
Sbjct: 856 AVINADVTIH-------IFQTTLAPAEFE-----------RPKYTFLVYE-DVPEDSPIG 896
Query: 166 TSIARVSATDADIGTNGEFYY--SFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEIL 223
T AR + ++ +Y S D F+IHP G I LD+ + + +
Sbjct: 897 TVKAR-----EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 224 AADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDD 280
A GS+ S ++ + + N+ P + P A + +D
Sbjct: 952 AQ------LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAED 1005
Query: 281 CDQGANGDIASLSIVAGDLLQQFRTVRSFPG----SKEYKVKAIGGIDWDSHPFGYNLTL 336
D G NG L ++ PG + V + G LTL
Sbjct: 1006 RDSGRNG------------LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
Query: 337 QAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIP--- 393
+A+D+G PQ + + + V + + FE VY+ E+SE P T ++ +A P
Sbjct: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
Query: 394 --AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTT---SD---RKA 445
A S LRY + + A F + TG I + + + V D +
Sbjct: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
Query: 446 STKVLVKVLGANSNPPEFTQTAYKAAFDEN-VPIGTTVMSLSAVDPDEGENGYVTYSIAN 504
ST V+V+V N N P F +E+ VP G + ++A+D D G+NG + Y + +
Sbjct: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLS 1232
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLND 564
F ++ TG + LD E + + + +D G P R + +++ ++ND
Sbjct: 1233 DGKF-FKMNPNTGELINWVALDREHRGH-HEMTVLVTDRGSP-PRNATMAVYVSVTDIND 1289
Query: 565 NTPLFEKI----NCEGTIPRDLGVGEQITTVSAIDADE 598
N P F + + V +TTV A D DE
Sbjct: 1290 NRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 1327
Score = 53.5 bits (127), Expect = 5e-06
Identities = 60/263 (22%), Positives = 100/263 (38%), Gaps = 20/263 (7%)
Query: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
F HL Y V V E+ + T + + A +RY + +F Y +
Sbjct: 1084 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT--GW 1141
Query: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153
+LR + +T N + + E T V V+V D ND P F
Sbjct: 1142 IYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 1195
Query: 154 YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYL 213
+ + E+ + I +++A D D G NG+ Y F ++P +G ++ LD
Sbjct: 1196 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDRE 1255
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAP----VITAVTLSPSELDR 269
+EM +L DR GS ++ + V + N+ P + L L+
Sbjct: 1256 HRGHHEMTVLVTDR-----GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
Query: 270 DPAYAIVT---VDDCDQGANGDI 289
P +VT D D+G N ++
Sbjct: 1311 QPVNMLVTTVFAKDPDEGNNAEV 1333
Score = 39.7 bits (91), Expect = 0.070
Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 8/115 (6%)
Query: 88 YILGDFCFLRIRTKGG---NTAILNREVKDHYTLIVKALEKNTNVEARTK-VRVQVLDTN 143
++L D F ++ G N L+RE + H+ + V ++ + T V V V D N
Sbjct: 1229 FLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
Query: 144 DLRPLFSPT----SYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDM 194
D RP F V + E + + V A D D G N E YS M
Sbjct: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1247 DMQVIVSNV-PPTLVEKKI 1264
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTA 1207
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1238 VLVSVVNQLD 1247
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 337 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 451
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 512 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 569
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 570 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 630 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 685
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 744
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 745 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 918
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 971
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1029
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1085
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1206 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1264
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1265 EDLTEILDRYV 1275
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 772 YTAVKLNREVRDYYELVVVATDG 794
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 868 HPFTGELSLLRSL 880
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 351 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 525 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 632
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 693 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 807 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 984 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1042
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1155
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1156 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1216 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1263
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1264 ---VESIGARRHGDAFSLEDYTKCDLTV 1288
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 350 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 469 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 526 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 582 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 636
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 637 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 752
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1225 DMQVIVSNV-PPTLVEKKI 1242
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 74 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 133
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 192
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 193 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 253 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 364
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 365 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 422
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 423 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 480
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 539
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 600 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 654
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 655 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 714 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 829 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 886
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 887 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 946
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 947 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1005
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1006 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1059
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1060 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1117
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1118 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1208
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 212
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 271
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 272 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 331
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 332 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 366
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 367 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 417 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 471
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 472 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 531
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 532 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 590
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 591 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 646
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 647 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 702
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 759
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 876
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 877 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 928
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 989 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1045
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1104
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTA 1185
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 96 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 156 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 215
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 216 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 331
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 332 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 387
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 388 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 445
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 446 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 564
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 565 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 622
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 679
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 680 TVNIVVT-------------------------------------------DVNDNAPVFD 696
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 697 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 752
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 989 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1039 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1158 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1216 VLVSVVNQLD 1225
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 435
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 436 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 491
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 550
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 551 MIVGRT---YALTVQAADN---------------------------------------AP 568
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 626 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 684
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 685 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 741
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 742 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 798
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 855
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 856 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 910
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1085
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1137
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1138 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1184
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 469 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 519
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 520 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 579 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 636
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 696
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 750
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 989 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1038
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1039 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1094
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1095 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1154
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1155 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1211
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 168
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 349 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 406 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 465
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 466 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 520
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 521 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 573
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 694 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 746
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 747 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 805
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 806 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 981
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1039
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1040 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1092
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1093 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1152
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1153 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1209
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1210 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1265
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 347
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 348 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 407 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 523 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 635
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 636 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 694
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 695 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 748
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 749 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 809 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 860 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 916
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 917 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 976
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1035
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1036 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1092
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1093 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1151 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1209
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1210 LSGKADVLVSVVNQ 1223
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 75 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 194
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 195 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 254
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 255 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 315 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 373
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 374 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 429
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 430 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 489
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 490 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 547
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 548 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 607
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 608 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 663
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 664 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 722
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 723 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 896
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 897 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 949
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1007
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1008 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1063
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1064 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1123
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1124 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1183
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1184 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1242
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1243 EDLTEILDRYV 1253
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 371
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 486
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 487 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 545
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 546 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 605
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 606 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 661
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 662 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 713
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 714 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 770
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 771 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 828 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 887
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 888 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 947
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 948 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1007
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1008 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1062
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1063 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1122
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1123 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1180
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1181 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 388 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 444
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 445 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 503
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 504 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 564 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 618
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 619 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 670
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 671 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 720
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 838
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 839 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 894
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 895 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 954
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 955 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 987
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 988 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1029
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1030 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1146 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1206 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1247
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 169
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 170 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 281
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 342 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 398
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 459 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 516
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 517 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 631
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 632 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 690
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 691 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 749
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 750 YTAVKLNREVRDYYELVVVATDG 772
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 404 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 463
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 464 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 520
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 521 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 580
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 637
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 683
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 502 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 556
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 557 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 609
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 670 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 729
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 730 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 785
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 845
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 846 HPFTGELSLLRSL 858
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 589 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 643
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 644 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 694 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 802
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 854
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 911
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 912 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1031 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1085
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1199
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1200 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1243
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1247 DMQVIVSNV-PPTLVEKKI 1264
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTA 1207
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1238 VLVSVVNQLD 1247
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 337 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 451
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 512 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 569
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 570 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 630 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 685
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 744
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 745 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 918
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 971
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1029
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1085
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1206 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1264
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1265 EDLTEILDRYV 1275
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 772 YTAVKLNREVRDYYELVVVATDG 794
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 868 HPFTGELSLLRSL 880
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 378 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 491
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 492 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 551
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 552 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 610 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 659
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 720 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 774
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 834 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1011 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1069
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1070 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1129
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1130 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1182
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1183 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1242
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1243 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1290
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1291 ---VESIGARRHGDAFSLEDYTKCDLTV 1315
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 377 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 495
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 496 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 553 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 608
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 609 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 663
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 664 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 721
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 722 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 779
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 840 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 898 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1071
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1072 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1131
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1252 DMQVIVSNV-PPTLVEKKI 1269
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 101 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 160
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 219
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 220 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 280 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 391
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 392 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 449
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 450 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 507
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 508 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 566
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 567 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 626
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 627 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 681
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 682 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 741 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 795
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 855
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 856 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 913
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 914 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 973
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 974 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1032
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1033 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1086
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1087 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1144
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1145 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1204
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1205 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1235
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 239
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 298
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 299 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 358
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 359 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 393
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 394 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 443
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 444 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 498
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 499 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 558
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 559 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 617
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 618 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 673
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 674 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 729
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 786
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 847 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 903
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 904 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 955
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1016 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1072
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1073 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1131
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTA 1212
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 123 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 182
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 242
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 243 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 358
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 359 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 415 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 472
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 473 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 532
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 533 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 591
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 592 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 649
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 650 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 706
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 707 TVNIVVT-------------------------------------------DVNDNAPVFD 723
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 724 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 779
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 840 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 898 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1016 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1066 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1124
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1125 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1184
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1185 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1242
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1243 VLVSVVNQLD 1252
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 462
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 463 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 518
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 519 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 577
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 578 MIVGRT---YALTVQAADN---------------------------------------AP 595
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 596 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 652
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 653 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 711
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 712 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 768
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 769 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 825
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 826 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 882
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 883 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 937
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1058 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1112
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1164
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1165 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1211
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 437 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 495
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 496 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 546
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 547 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 606 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 663
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 664 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 723
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 777
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 778 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 837
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 838 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 896 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1065
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1066 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1121
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1122 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1181
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1182 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1238
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 195
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 376 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 433 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 492
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 493 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 547
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 548 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 721 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 773
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 774 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 832
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 833 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1008
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1066
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1067 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1119
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1120 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1179
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1180 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1236
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1237 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1292
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 374
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 375 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 434 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 489
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 490 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 549
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 550 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 662
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 663 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 721
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 722 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 775
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 776 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 835
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 836 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 886
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 887 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 943
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 944 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1003
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 1004 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1062
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1063 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1119
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1120 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1177
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1178 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1236
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1237 LSGKADVLVSVVNQ 1250
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 102 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 161
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 221
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 342 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 400
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 401 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 456
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 457 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 516
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 517 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 574
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 575 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 634
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 635 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 690
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 691 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 749
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 750 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 806
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 807 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 866
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 867 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 923
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 924 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 976
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 977 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1034
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1035 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1090
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1091 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1150
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1151 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1210
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1211 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1269
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1270 EDLTEILDRYV 1280
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 398
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 458
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 459 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 513
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 514 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 572
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 573 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 632
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 633 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 688
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 689 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 740
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 741 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 797
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 798 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 854
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 855 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 914
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 915 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 974
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 975 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1035 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1089
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1090 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1149
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1150 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1207
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1208 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 415 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 471
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 472 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 530
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 531 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 590
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 591 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 645
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 646 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 697
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 698 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 747
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 748 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 807
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 808 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 865
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 866 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 921
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 922 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 981
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 982 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1014
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1015 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1056
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1057 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1172
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1173 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1232
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1233 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1274
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 196
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 197 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 308
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 309 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 369 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 425
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 426 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 485
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 486 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 543
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 544 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 658
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 659 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 717
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 718 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 776
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 777 YTAVKLNREVRDYYELVVVATDG 799
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 431 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 490
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 491 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 547
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 548 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 607
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 664
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 665 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 710
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 478 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 528
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 529 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 583
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 584 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 636
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 637 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 696
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 697 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 756
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 757 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 812
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 813 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 872
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 873 HPFTGELSLLRSL 885
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 616 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 670
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 671 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 721 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 774
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 829
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 830 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 881
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 882 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 938
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 939 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1058 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1112
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1172 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1226
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1227 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1270
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1247 DMQVIVSNV-PPTLVEKKI 1264
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTA 1207
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1238 VLVSVVNQLD 1247
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 337 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 451
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 512 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 569
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 570 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 630 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 685
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 744
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 745 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 918
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 971
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1029
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1085
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1206 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1264
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1265 EDLTEILDRYV 1275
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 772 YTAVKLNREVRDYYELVVVATDG 794
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 868 HPFTGELSLLRSL 880
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 351 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 525 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 632
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 693 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 807 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 984 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1042
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1155
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1156 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1216 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1263
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1264 ---VESIGARRHGDAFSLEDYTKCDLTV 1288
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 350 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 469 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 526 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 582 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 636
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 637 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 752
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1225 DMQVIVSNV-PPTLVEKKI 1242
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 74 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 133
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 192
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 193 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 253 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 364
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 365 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 422
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 423 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 480
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 539
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 600 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 654
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 655 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 714 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 829 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 886
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 887 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 946
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 947 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1005
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1006 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1059
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1060 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1117
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1118 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1208
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 212
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 271
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 272 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 331
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 332 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 366
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 367 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 417 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 471
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 472 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 531
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 532 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 590
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 591 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 646
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 647 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 702
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 759
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 876
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 877 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 928
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 989 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1045
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1104
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTA 1185
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 96 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 156 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 215
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 216 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 331
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 332 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 387
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 388 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 445
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 446 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 564
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 565 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 622
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 679
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 680 TVNIVVT-------------------------------------------DVNDNAPVFD 696
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 697 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 752
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 989 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1039 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1158 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1216 VLVSVVNQLD 1225
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 435
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 436 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 491
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 550
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 551 MIVGRT---YALTVQAADN---------------------------------------AP 568
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 626 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 684
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 685 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 741
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 742 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 798
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 855
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 856 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 910
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1085
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1137
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1138 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1184
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 469 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 519
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 520 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 579 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 636
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 696
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 750
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 989 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1038
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1039 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1094
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1095 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1154
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1155 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1211
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 168
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 349 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 406 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 465
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 466 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 520
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 521 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 573
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 694 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 746
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 747 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 805
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 806 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 981
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1039
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1040 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1092
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1093 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1152
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1153 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1209
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1210 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1265
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 347
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 348 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 407 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 523 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 635
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 636 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 694
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 695 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 748
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 749 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 809 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 860 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 916
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 917 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 976
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1035
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1036 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1092
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1093 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1151 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1209
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1210 LSGKADVLVSVVNQ 1223
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 75 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 194
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 195 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 254
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 255 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 315 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 373
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 374 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 429
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 430 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 489
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 490 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 547
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 548 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 607
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 608 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 663
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 664 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 722
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 723 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 896
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 897 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 949
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1007
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1008 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1063
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1064 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1123
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1124 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1183
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1184 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1242
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1243 EDLTEILDRYV 1253
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 371
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 486
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 487 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 545
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 546 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 605
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 606 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 661
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 662 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 713
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 714 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 770
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 771 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 828 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 887
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 888 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 947
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 948 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1007
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1008 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1062
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1063 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1122
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1123 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1180
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1181 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 388 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 444
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 445 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 503
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 504 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 564 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 618
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 619 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 670
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 671 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 720
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 838
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 839 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 894
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 895 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 954
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 955 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 987
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 988 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1029
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1030 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1146 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1206 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1247
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 169
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 170 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 281
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 342 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 398
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 459 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 516
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 517 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 631
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 632 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 690
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 691 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 749
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 750 YTAVKLNREVRDYYELVVVATDG 772
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 404 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 463
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 464 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 520
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 521 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 580
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 637
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 683
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 502 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 556
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 557 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 609
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 670 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 729
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 730 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 785
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 845
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 846 HPFTGELSLLRSL 858
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 589 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 643
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 644 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 694 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 802
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 854
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 911
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 912 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1031 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1085
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1086 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1199
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1200 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1243
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1247 DMQVIVSNV-PPTLVEKKI 1264
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTA 1207
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1238 VLVSVVNQLD 1247
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 337 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 451
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 512 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 569
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 570 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 630 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 685
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 744
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 745 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 918
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 971
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1029
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1085
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1206 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1264
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1265 EDLTEILDRYV 1275
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 772 YTAVKLNREVRDYYELVVVATDG 794
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 868 HPFTGELSLLRSL 880
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1247 DMQVIVSNV-PPTLVEKKI 1264
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTA 1207
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1238 VLVSVVNQLD 1247
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1232 LSGKADVLVSVVNQ 1245
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 337 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 451
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 512 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 569
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 570 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 630 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 685
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 744
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 745 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 918
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 919 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 971
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1029
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1085
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1206 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1264
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1265 EDLTEILDRYV 1275
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 772 YTAVKLNREVRDYYELVVVATDG 794
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 868 HPFTGELSLLRSL 880
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 314 bits (805), Expect = 1e-84
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 378 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 491
Query: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 492 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 551
Query: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 552 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609
Query: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 610 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 659
Query: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 720 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 774
Query: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 834 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1011 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1069
Query: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1070 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1129
Query: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1130 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1182
Query: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1183 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1242
Query: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1243 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1290
Query: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1291 ---VESIGARRHGDAFSLEDYTKCDLTV 1315
Score = 301 bits (771), Expect = 1e-80
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 377 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 495
Query: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 496 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 553 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 608
Query: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 609 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 663
Query: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 664 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 721
Query: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 722 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 779
Query: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 840 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 898 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1071
Query: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 1072 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1131
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Query: 3532 DIRVIEESIYPPAILPLEI 3550
D++VI ++ PP ++ +I
Sbjct: 1252 DMQVIVSNV-PPTLVEKKI 1269
Score = 291 bits (746), Expect = 8e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 101 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 160
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 219
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 220 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 280 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 391
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 392 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 449
Query: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 450 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 507
Query: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 508 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 566
Query: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 567 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 626
Query: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 627 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 681
Query: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 682 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 741 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 795
Query: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 855
Query: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 856 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 913
Query: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 914 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 973
Query: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 974 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1032
Query: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 1033 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1086
Query: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 1087 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1144
Query: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 1145 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1204
Query: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
TG +KT+ ++ + V ATD G+
Sbjct: 1205 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1235
Score = 288 bits (738), Expect = 7e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 239
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 298
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 299 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 358
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L
Sbjct: 359 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 393
Query: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 394 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 443
Query: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 444 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 498
Query: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 499 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 558
Query: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 559 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 617
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 618 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 673
Query: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 674 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 729
Query: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 786
Query: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 847 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 903
Query: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 904 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 955
Query: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1016 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1072
Query: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1073 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1131
Query: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 1499 PLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTA 1212
Score = 258 bits (659), Expect = 1e-67
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 123 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 182
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 242
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 243 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 358
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 359 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
+ ++ S LR V P F +Y T +++L+
Sbjct: 415 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 472
Query: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 473 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 532
Query: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 533 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 591
Query: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 592 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 649
Query: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 650 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 706
Query: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
+NI V VN + P F
Sbjct: 707 TVNIVVT-------------------------------------------DVNDNAPVFD 723
Query: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 724 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 779
Query: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 840 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 898 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1016 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1066 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1124
Query: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1125 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1184
Query: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1185 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1242
Query: 1231 VIVKILDEND 1240
V+V ++++ D
Sbjct: 1243 VLVSVVNQLD 1252
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 462
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 463 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 518
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 519 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 577
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 578 MIVGRT---YALTVQAADN---------------------------------------AP 595
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 596 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 652
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 653 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 711
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 712 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 768
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 769 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 825
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 826 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 882
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 883 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 937
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1058 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1112
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1164
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1165 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1211
Score = 249 bits (637), Expect = 3e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 437 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 495
Query: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 496 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 546
Query: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 547 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 606 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 663
Query: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 664 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 723
Query: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 777
Query: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 778 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 837
Query: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 838 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 896 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1016 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1065
Query: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1066 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1121
Query: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1122 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1181
Query: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1182 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1238
Score = 243 bits (620), Expect = 3e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 195
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 376 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
Query: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 433 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 492
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 493 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 547
Query: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 548 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 721 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 773
Query: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 774 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 832
Query: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 833 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 891 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1008
Query: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1066
Query: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 1067 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1119
Query: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 1120 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1179
Query: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 1180 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1236
Query: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 1237 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1292
Score = 240 bits (613), Expect = 2e-62
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 374
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 375 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 434 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 489
Query: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 490 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 549
Query: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 550 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 662
Query: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 663 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 721
Query: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 722 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 775
Query: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 776 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 835
Query: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 836 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 886
Query: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 887 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 943
Query: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 944 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1003
Query: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 1004 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1062
Query: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 1063 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1119
Query: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 1120 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1177
Query: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1178 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1236
Query: 2164 FSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1237 LSGKADVLVSVVNQ 1250
Score = 219 bits (557), Expect = 6e-56
Identities = 284/1211 (23%), Positives = 500/1211 (41%), Gaps = 137/1211 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 102 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 161
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 221
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 342 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 400
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKF 1300
Y+ + E + PL ++A DKD + + E+ + N++
Sbjct: 401 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSV 456
Query: 1301 FIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
F +TG+ + + SI A D + + + + + P+
Sbjct: 457 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 516
Query: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAK 1415
IS++ +T + D V + V + E + ++I G F ++K TG I +A
Sbjct: 517 ISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAP 574
Query: 1416 PLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDT 1469
++ Y LTV+A D + V+I+V+ N+ P+F Y + I E
Sbjct: 575 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 634
Query: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
+L + A D+ E + + Y +++ DP + F L TG L + LD E+ ++
Sbjct: 635 RVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYI 690
Query: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
L + D P + A + + V+D ND+AP F + + V QV A D
Sbjct: 691 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 749
Query: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD P
Sbjct: 750 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 806
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNT 1706
++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 807 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 866
Query: 1707 GDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQD 1757
F ++P +G + ++LD+E P + I GT G++T T + ++D
Sbjct: 867 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKD 923
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE--- 1813
ND PVF + Y G+++ A + + T + A DAD A V + V+
Sbjct: 924 MNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQ 976
Query: 1814 -PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDI 1872
P + F ++ +G + T ++L+ E T+IF V D G P + + +A V + V+
Sbjct: 977 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHP 1034
Query: 1873 NDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYK 1932
+ P + + KG V ++A + S ++YSI GN + F ++
Sbjct: 1035 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNI 1090
Query: 1933 TGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFT 1980
TG + V + R+ Y L V+A + V I +++ F
Sbjct: 1091 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1150
Query: 1981 QDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLS 2033
+ Y V E++ ++ + A + Y ++ P + F + +G++
Sbjct: 1151 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1210
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T F ++ F V T+++ V V V +Q D + N+P V K
Sbjct: 1211 -TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1269
Query: 2094 TEVGHVI-RYV 2103
++ ++ RYV
Sbjct: 1270 EDLTEILDRYV 1280
Score = 216 bits (549), Expect = 5e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
Query: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
Query: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 398
Query: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 458
Query: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 459 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 513
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 514 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 572
Query: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 573 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 632
Query: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 633 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 688
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 689 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 740
Query: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 741 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 797
Query: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 798 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 854
Query: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 855 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 914
Query: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 915 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 974
Query: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 975 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1035 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1089
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1090 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1149
Query: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1150 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1207
Query: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1208 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 415 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 471
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 472 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 530
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 531 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 590
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 591 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 645
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 646 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 697
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 698 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 747
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 748 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 807
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 808 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 865
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 866 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 921
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 922 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 981
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 982 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1014
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 1015 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1056
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1057 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1172
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1173 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1232
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1233 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1274
Score = 170 bits (431), Expect = 3e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 196
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 197 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 308
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 309 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 369 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 425
Query: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 426 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 485
Query: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 486 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 543
Query: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 544 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 658
Query: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 659 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 717
Query: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 718 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 776
Query: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
A K ++ Y L V TDG
Sbjct: 777 YTAVKLNREVRDYYELVVVATDG 799
Score = 142 bits (359), Expect = 6e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 431 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 490
Query: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 491 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 547
Query: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 548 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 607
Query: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 664
Query: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 665 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 710
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 478 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 528
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 529 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 583
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 584 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 636
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 637 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 696
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 697 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 756
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 757 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 812
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 813 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 872
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 873 HPFTGELSLLRSL 885
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 616 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 670
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 671 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 721 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 774
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 829
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 830 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 881
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 882 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 938
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 939 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 998 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1057
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1058 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1112
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1113 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1172 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1226
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1227 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1270
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 311 bits (798), Expect = 7e-84
Identities = 332/1235 (26%), Positives = 544/1235 (44%), Gaps = 154/1235 (12%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 378 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1059 HDEDAR---------RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109
D+D +D E+ + D + V T + +DRE Y ++
Sbjct: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
A D V S + + I+V D NDN P E Y + + SV+Q+ A D D
Sbjct: 494 TAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551
Query: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KST 1227
SN ++ Y+I G QG F I+ TGLI T + ++ + L V DN P +++
Sbjct: 552 SNGEITYEILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
Query: 1228 IARVIVKIL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAE 1286
I V +++L N + P+F Q Y + + E + L ++ ATD++
Sbjct: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDS 659
Query: 1287 ISYSIEDGNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI-- 1343
I+Y+IE+G+ F + TG+++ K + I +GRP +ST ++I
Sbjct: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
Query: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHF 1402
++ P +P +V+E + A + V + +P GI + GN+++ F
Sbjct: 720 TDVNDNAPVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 775
Query: 1403 DVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFST 1458
+ G+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+
Sbjct: 776 RI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTN 833
Query: 1459 SKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSE 1518
S Y V++ E+ T ILQI A D D + Y + R P F L P TG L
Sbjct: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLR 890
Query: 1519 KLDHEAV--HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYES 1574
LD+EA + ++T +V D+ + A + V V D ND+ P F+ YKG V
Sbjct: 891 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 950
Query: 1575 AAVGSVVLQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSN 1629
A G+ + V A D D + V Y ++ + F ++ G + T L+
Sbjct: 951 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
Query: 1630 QAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGM 1688
+ L+V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+
Sbjct: 1011 TTIFKLVVVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1069
Query: 1689 VTAHS-QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM----- 1742
++A + S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1070 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
Query: 1743 ----AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAAD 1798
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D
Sbjct: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATD 1182
Query: 1799 ADKDSNALLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD---- 1851
D + +++ Y ++ P + F +++ TG I T + S F F V D
Sbjct: 1183 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
Query: 1852 --MGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNAT 1904
G + + + VI N P + K + + + +L Y G KV+
Sbjct: 1243 GLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV----- 1297
Query: 1905 DADSSAFSQLIYSITEGNIGEKFSM-DYKTGALTV 1938
+ SI G+ FS+ DY LTV
Sbjct: 1298 ----------VESIGARRHGDAFSLEDYTKCDLTV 1322
Score = 299 bits (766), Expect = 4e-80
Identities = 318/1166 (27%), Positives = 514/1166 (44%), Gaps = 118/1166 (10%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
V + D +D P F R Y+ I T ++ + D
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 377 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 2739 KG--NTPES-------------NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILA 2780
K + P S N S Q+G L L + +D E + Y FSI A
Sbjct: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
Query: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
+ E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+
Sbjct: 496 FDGVQESEPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 552
Query: 2841 NGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQ 2897
NG++ Y + V F IN TG IT ++ Y + V A+D+ E+
Sbjct: 553 NGEITYEI----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 608
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYF 2957
T ++V + N SPPRF +Y +SE G V+ L TD + + I TY
Sbjct: 609 SICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYA 663
Query: 2958 ITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLD 3015
I GDP F + + + + K LDRE D Y+L ITA+DG +S A V + V D
Sbjct: 664 IENGDPQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTD 721
Query: 3016 ANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPD 3075
NDN+PV + L + + + Q+ ATD D N ++ Y+ LG+ F++
Sbjct: 722 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-S 779
Query: 3076 TGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAIT 3133
G + T+ L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y +
Sbjct: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
Query: 3134 VFENTEPGTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL- 3191
V EN GT + +++A D D G N + Y + F+++ +G + L + LD E
Sbjct: 840 VEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 897
Query: 3192 ---QAVYTLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGT 3247
+A T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT
Sbjct: 898 PDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGT 955
Query: 3248 EVLQVYAASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYY 3302
+ VYA D + + Y + F ++ +G V NL+ E + +
Sbjct: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1015
Query: 3303 LTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDA 3362
L V A D G P +S ATV + V + P F+Q+ Y + + +++ V++ A
Sbjct: 1016 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1074
Query: 3363 DGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDN 3415
N I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++
Sbjct: 1075 ---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1131
Query: 3416 GSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPP 3475
P + NT V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ +
Sbjct: 1132 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1191
Query: 3476 FFFTIVTGNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ-- 3524
+ I+ E + F V G++ T+ + ++ QV D +GK
Sbjct: 1192 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1251
Query: 3525 LSSLTYIDIRVIEESIYPPAILPLEI 3550
+S + +D++VI ++ PP ++ +I
Sbjct: 1252 VSVVNQLDMQVIVSNV-PPTLVEKKI 1276
Score = 288 bits (736), Expect = 1e-76
Identities = 310/1178 (26%), Positives = 507/1178 (43%), Gaps = 140/1178 (11%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 101 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 160
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 219
Query: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 220 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
Query: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
A+P P E I V P+ + + + + YSI G
Sbjct: 280 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
Query: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 391
Query: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSE-------PNR 2316
D N+ P F SY + E++ +G TS +++ A D D E P +
Sbjct: 392 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTK 449
Query: 2317 GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
+F N S T ++LL+ +D E+ + +T + A DG S VIV
Sbjct: 450 DPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIV 507
Query: 2377 TVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHK 2436
+ V D NDN P F + Y+ + G V + A DAD ++ Y IL G
Sbjct: 508 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQG 566
Query: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-P 2490
F+I+ TG+IT++ + Y+L + +D S V++ V+ N S P
Sbjct: 567 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
Query: 2491 AFLQNEYEVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQI 2548
F Q Y +E++E + +++ ++ TD GDS +TY I N + F ++E I
Sbjct: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGI 681
Query: 2549 FTLEK-LDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607
TL K LDRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 682 LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
Query: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667
V +V A+D D G N + Y++ NL +G I T L +
Sbjct: 741 EEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRD 795
Query: 2668 FFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA 2727
++ V A D + S + + +K+L + P F+ YT V E++P GT I I A
Sbjct: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 855
Query: 2728 EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQD 2785
+ + +PE F + +G L L +SLD+E + SI L
Sbjct: 856 KDVDLGANVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 913
Query: 2786 DHEMVASV-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNG 2842
M + V++ VKD ND PVF Y+ + + G+ + + A DAD
Sbjct: 914 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 973
Query: 2843 QVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTA 2902
+V Y +D Q F + ++G + T L+ E +++ VVA D GE + +SS+A
Sbjct: 974 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSA 1032
Query: 2903 IVDVTVTDVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGG 2961
V + V + PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G
Sbjct: 1033 TVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSG 1086
Query: 2962 DPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEV 3011
+ F + I +YV PLD E R +Y+L + A + S+ A V +
Sbjct: 1087 NEEDTFGINNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1144
Query: 3012 KVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGA 3067
++ D N++ PV +K Y + ED ++++ ATD D + + + Y L + G
Sbjct: 1145 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1204
Query: 3068 EKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
E F + TG +KT+ ++ + V ATD G+
Sbjct: 1205 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
Score = 286 bits (731), Expect = 4e-76
Identities = 315/1163 (27%), Positives = 512/1163 (44%), Gaps = 145/1163 (12%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 239
Query: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 298
Query: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 299 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 358
Query: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
K L I A P + + + ++L E
Sbjct: 359 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI-----------------EILDEN--NQ 396
Query: 691 NKLHNQGEVEDIFFDSHSVNAHI-PQFRSTLPTGIQV--KENQPVGSSVIFMNSTDLDTG 747
+ + +S V A I T P I K+ + V S + +L
Sbjct: 397 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLF 456
Query: 748 FNGKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAA 804
N + S F + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 457 LN----------DYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESE 503
Query: 805 WRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD 864
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 504 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 563
Query: 865 TD-TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVN 921
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N
Sbjct: 564 AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNN 622
Query: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKL 979
+PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ +
Sbjct: 623 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSET 678
Query: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
+G + + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++
Sbjct: 679 TGILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLP 734
Query: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDR 1099
+ + + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+R
Sbjct: 735 RNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 791
Query: 1100 ESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV 1159
E +Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++
Sbjct: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
Query: 1160 QIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD 1219
QIEA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 852 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLV 908
Query: 1220 N-----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV 1274
G+ P IA V V + D ND P F ++ YK + PD + P+ V
Sbjct: 909 EAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTV 960
Query: 1275 IATDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKA 1327
A D D P + + Y ++D F +E +G V ++ I L + A
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 1328 VDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI 1387
D+G P SS+ + I + P P +E + V E M+GVIS
Sbjct: 1021 FDDGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
Query: 1388 PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL-------- 1439
+ + I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1078 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSK 1136
Query: 1440 ---TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSS 1496
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1137 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1196
Query: 1497 RDPLSLKK--FRLDPATGSLYTS 1517
P+ K F ++ TG + T+
Sbjct: 1197 IPPIKEGKEGFVVETYTGLIKTA 1219
Score = 281 bits (719), Expect = 1e-74
Identities = 274/1034 (26%), Positives = 455/1034 (44%), Gaps = 116/1034 (11%)
Query: 765 FMIDMETGMLKILSPLDRETTDKYTLNITV-YDLGIPQKAAWRLLHVVVVDANDNPPEFL 823
F + T L +L P++R+ K+ L I D G P A + LH+ ++D N+ P F
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFT 401
Query: 824 QESYFVEVSEDKEVHSEI---------IQVEATDKDL-----------GPNGHVTYSIVT 863
SY + E V + I +++ A DKD+ P H+ + T
Sbjct: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
Query: 864 DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
T + +T + + +P+DRE Q ++ I A D +E V+V + + D NDN
Sbjct: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES----EPVIVNIQVMDANDN 517
Query: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAV 983
PTF +Y V V D+ G ++ L A D D G +G++ Y +L +G+F ++K +G +
Sbjct: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 577
Query: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVS-LSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
I ++ + Y LTV+A D P +S C V +EV+ N N PP F +
Sbjct: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLE 636
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E VG++++ + A D R I Y+I +G VF + E TG++ LDREST
Sbjct: 637 ISEAMRVGAVLLNLQATD---REGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 693
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV--- 1159
Y L + A+D G +S + I V DVNDNA PV+ P + P+++SVV
Sbjct: 694 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNA-----PVFDPYL----PRNLSVVEEE 743
Query: 1160 ------QIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHIL 1213
Q++A DPD+ N ++ Y + GN F I + T KL+RE +D + L
Sbjct: 744 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYEL 799
Query: 1214 EVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYH 1273
V TD P+ + + +K+LD +DN P F Y + L E P +
Sbjct: 800 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV-LVEENLP------AGTTILQ 852
Query: 1274 VIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYD---ILSIKA 1327
+ A D D G N +SY I F + P TG +S R + A + + ++A
Sbjct: 853 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 910
Query: 1328 VD--NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP 1385
D P +T + ++ ++ P + + ++ P+ + +PP
Sbjct: 911 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY-KGMVAPDAVKGTPIT-TVYAEDADPP 968
Query: 1386 GIPL------WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-TDGTTTI 1438
G+P D+ S F+V++ +G +I L+ E + + L V A DG +
Sbjct: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
Query: 1439 LTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPE---TEILQISAVDQDEKNKLIYTLQ 1494
+ +K++ + P+F+ +Y + A + ++ +A++Q ++Y++
Sbjct: 1029 SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ----SIVYSIV 1084
Query: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEA-------VHQHTLTVMVRDQDVPVKRNFAR 1547
S + F ++ TG +Y + LD+E V +L V++ + VP K N A+
Sbjct: 1085 SGNEE---DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
Query: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLY-----SIE 1602
+ + + D N+H P F Y G V E A + + VL+V A DKD G + + Y I+
Sbjct: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
Query: 1603 SGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV----- 1657
G G F+++ G IKTA ++ + V ATD +S V + V
Sbjct: 1202 EGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
Query: 1658 --TIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPH 1715
I N P K ++ + I VV I GDAF + +
Sbjct: 1260 MQVIVSNVPPTLVEK----KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDY 1315
Query: 1716 SGTIITQKALDFET 1729
+ +T A+D +T
Sbjct: 1316 TKCDLTVYAIDPQT 1329
Score = 255 bits (652), Expect = 6e-67
Identities = 318/1217 (26%), Positives = 514/1217 (42%), Gaps = 176/1217 (14%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 123 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 182
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 242
Query: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
L + ++ LTV + ++ P+ L P+ D
Sbjct: 243 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
+P + DQ N S SI+ G R P + E + + +
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 358
Query: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 359 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 414
Query: 382 PNTPVVMVKAIPAYSHLRYVF--------------KSTPGKAKFSLNYN----------T 417
+ ++ S LR V P F +Y T
Sbjct: 415 VGATI--SDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGIT 472
Query: 418 GLISILEPVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDE 474
+++L+PV R++ + +T D ++ V ++V+ AN N P F + +Y
Sbjct: 473 RYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 532
Query: 475 NVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVY 534
++ G +V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y
Sbjct: 533 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTY 591
Query: 535 TLRIRASDWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTV 591
L ++A+D P R + T+ + L N + P F ++ I + VG + +
Sbjct: 592 ALTVQAADNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650
Query: 592 SAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGE 651
A D E + Y IE G+ F+L+ +G+L+L ++L + L ITA+DG
Sbjct: 651 QATDR-EGDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGR 706
Query: 652 NFAT-PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVN 710
T +NI V VN
Sbjct: 707 PDGTSTATVNIVVT-------------------------------------------DVN 723
Query: 711 AHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDME 770
+ P F LP + V E + + V + +TD D G NG++ Y++ GN ++ F I
Sbjct: 724 DNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TS 779
Query: 771 TGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVE 830
G + L+RE D Y L + D + + + L + V+D +DN P F +Y V
Sbjct: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
Query: 831 VSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL- 887
V E+ + I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E
Sbjct: 840 VEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 897
Query: 888 -QHEHSLK--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGT 944
E S+ +EA D P +TV V V +D+ND PP F Y+ V D +GT
Sbjct: 898 PDQEASITFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGT 955
Query: 945 VI--MWLEAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYN 998
I ++ E DP + +VRY + D + F+V++ SG V L+ E ++
Sbjct: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1015
Query: 999 LTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVM 1054
L V A D G+PV +SS+ V++ V LHP F ++ V E A G++V
Sbjct: 1016 LVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
Query: 1055 TVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQ 1114
+SA A + I YSI G+ F I TGVI + LD E+ + Y L V A
Sbjct: 1069 VISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1124
Query: 1115 GVV-------PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPD 1167
VV S+ ++YIE++D N++ P + Y + E++ SV++++A D D
Sbjct: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
Query: 1168 SSSNDKLMYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP 1223
+ + + Y++ +GF + TGLI T+ ++ +V TD+
Sbjct: 1185 TGNYSVMAYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGK 1242
Query: 1224 PKSTIARVIVKILDEND 1240
S A V+V ++++ D
Sbjct: 1243 GLSGKADVLVSVVNQLD 1259
Score = 255 bits (651), Expect = 8e-67
Identities = 261/956 (27%), Positives = 432/956 (45%), Gaps = 135/956 (14%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 466 TAYKAAFDENVPIGTTVM-SLSAVDP-----------DEGENGYVT-----YSIANLNHV 508
+Y+ E+ P+G T+ SL+ P D +G T + N
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS 462
Query: 509 PFAIDH--FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566
F + T ++ + +D E + YT I A D + V+ I + + NDNT
Sbjct: 463 VFTVTQTGITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNT 518
Query: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVL 624
P F +I+ + + D+ G+ + ++A+DADE + Y+I G + DF +N +G++
Sbjct: 519 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLI 577
Query: 625 SLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLA 684
++ + +G ++L + A D
Sbjct: 578 TIAPGVEMIVGRT---YALTVQAADN---------------------------------- 600
Query: 685 EKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDL 744
A + + ++ + N P L +++ E VG+ ++ + +TD
Sbjct: 601 -----APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 655
Query: 745 DTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAA 804
+ + YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P +
Sbjct: 656 E---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTS 711
Query: 805 WRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI 861
+++VV D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+
Sbjct: 712 TATVNIVVTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL 768
Query: 862 VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN 921
+ F I S G + A L+RE++ + L + A D A P+ ST+ + + + D++
Sbjct: 769 GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDID 825
Query: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKL 979
DN P F Y V V E+LP GT I+ +EA D DLG S ++R + H F +
Sbjct: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPF 882
Query: 980 SGAVRIVQQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
+G + +++ LD+E ++ V A D P +++ V V V D+N+ +PPV
Sbjct: 883 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPV 937
Query: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEET 1088
FS + KG V DA G+ + TV A D D +RY + D +F++ E++
Sbjct: 938 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997
Query: 1089 GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEI 1148
G + T L+ E T+ + L V A D G +SS + I V + T E P +
Sbjct: 998 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV 1057
Query: 1149 MENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQ 1208
E + K V I A ++ N ++Y I SGN + F I+ TG+I LD E +
Sbjct: 1058 SELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETR 1112
Query: 1209 DEHI-------LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD 1261
++ LEV + + P KS A+V ++I DEN++ P F +KFY + E
Sbjct: 1113 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE----- 1167
Query: 1262 RERNARR-EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+AR + V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1168 ---DARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1218
Score = 249 bits (635), Expect = 6e-65
Identities = 282/1148 (24%), Positives = 489/1148 (42%), Gaps = 137/1148 (11%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS----------RKLDREQQDEHILEVT 1216
D D + + +P+ ++ T + T T + +DRE+Q + +T
Sbjct: 437 DIE--DVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
Query: 1217 VTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
D + I V ++++D NDN P F + Y + + +P + + + A
Sbjct: 495 AFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTA 545
Query: 1277 TDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP- 1333
D DEG N EI+Y I G + G F I TG+++ G L+++A DN P
Sbjct: 546 VDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 604
Query: 1334 -QKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWF 1391
+++S ++IE + P + P F + ++ + E+ V A ++ + + + G + +
Sbjct: 605 ERRNSICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 662
Query: 1392 DITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDT 1449
I G+ F++ + TG + + K LD E Y L + A+DG T V I V D
Sbjct: 663 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDV 722
Query: 1450 NDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRL 1507
ND+ P F + + + Q+ A D D ++ Y+L + + FR+
Sbjct: 723 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRI 777
Query: 1508 DPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSY 1567
+ GS+YT+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y
Sbjct: 778 T-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
Query: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD- 1626
V E+ G+ +LQ+ A D D G N V Y I S + + F + P G + + LD
Sbjct: 837 TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
Query: 1627 ---RSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIG 1683
+A +V+A D I +V + V ++ P F+ + Y ++ G
Sbjct: 895 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
Query: 1684 SFVGMVTAHS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIY 1733
+ + V A S V Y + D F++ SG +IT+ L+ E I+
Sbjct: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 1014
Query: 1734 TLII----QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDR 1788
L++ G + S +LV E P F Q EY +SE A+ ++V
Sbjct: 1015 KLVVVAFDDGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV---- 1067
Query: 1789 NVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQ 1848
VI AA N +VY IV + F I++ TG I+ LDYE + + VQ
Sbjct: 1068 ---GVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
Query: 1849 VHDMGTPRL-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNA 1903
+ A V + + D N+ PPVF K Y + V+ V A
Sbjct: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
Query: 1904 TDADSSAFSQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRAS 1955
TD D+ +S + Y + EG + E ++ KT L RS ++ V A+
Sbjct: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIAT 1237
Query: 1956 DGRFAGLT 1963
D GL+
Sbjct: 1238 DDYGKGLS 1245
Score = 242 bits (617), Expect = 7e-63
Identities = 294/1157 (25%), Positives = 499/1157 (43%), Gaps = 139/1157 (12%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 374
Query: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 375 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 1382 -------VEPPGIPL---WFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTV 1429
V P G+P + +Y S F V + T + + +P+D E++ Y ++
Sbjct: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 1430 EATDGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--K 1486
A DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE
Sbjct: 494 TAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
Query: 1487 NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFA 1546
++ Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 554 GEITYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
Query: 1547 RIVVNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES 1603
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+
Sbjct: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 666
Query: 1604 GNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNA 1663
G+ F + G + K LDR + Y L++ A+D G P + +V I VT ++
Sbjct: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
Query: 1664 SPKF---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPH 1715
+P F + SV E +FVG V A V Y + GN + F I
Sbjct: 726 APVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-S 779
Query: 1716 SGTIITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGL 1773
+G+I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L
Sbjct: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
Query: 1774 ISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVL 1833
+ E+ + +L I A D D +N + Y I P V +FA+ TG + +
Sbjct: 840 VEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 890
Query: 1834 SLDYE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888
SLDYE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 891 SLDYEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 947
Query: 1889 LLPTYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNT 1941
KG + TV A DAD S++ Y + + F ++ +G + V
Sbjct: 948 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1007
Query: 1942 TQLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAET 1997
+ + ++L V A D + +VKI V E +FTQ+ Y V E +T+
Sbjct: 1008 EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTM 1066
Query: 1998 LAVITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEA 2046
+ VI+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++
Sbjct: 1067 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1123
Query: 2047 FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAV 2106
+VV+ S A V ++ ++D+N++ PVF Y V D + + V A
Sbjct: 1124 LEVVLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
Query: 2107 DRDSGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGG 2160
D+D+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDY 1240
Query: 2161 NPAFSAEVIVPITVMNK 2177
S + V ++V+N+
Sbjct: 1241 GKGLSGKADVLVSVVNQ 1257
Score = 242 bits (617), Expect = 7e-63
Identities = 290/1203 (24%), Positives = 498/1203 (41%), Gaps = 164/1203 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 195
Query: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
Query: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 376 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
Query: 2010 ---------EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVV 2050
P +P+ ++ + V + T T P DRE+Q+ +
Sbjct: 433 ALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 492
Query: 2051 VEV---TEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107
+ +E +P V+V + V D NDN P F + Y V D G + +TAVD
Sbjct: 493 ITAFDGVQESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 547
Query: 2108 RDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDG 2159
D G NGE+ Y + +G G+ + K L T+ + Y +TV A D
Sbjct: 548 ADEGSNGEITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 2160 GNPAFSAEVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV 2214
PA I + + N++ P F + YS EI+E+++V + ++++QA EG +
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 2215 FYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVD 2274
Y+I +GDP F ++ TG++ + LD E+ Y L I A+D + V+I+V
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 2275 DINDNPPVF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHD 2331
D+NDN PVF ++ +V EA+ V QV+ATD D+ N + Y + GN ++
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NN 773
Query: 2332 HFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
F + S+ + + ++ L+ E + + V A DG + S + + + V D++DN P+F
Sbjct: 774 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 832
Query: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN 2451
Y + E+ P G + ++A D D + Y I S F + TG ++L
Sbjct: 833 NSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLR 890
Query: 2452 LHRHALKPFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAEN 2504
+ P +++ F V V V N + P F + Y+ +A +
Sbjct: 891 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 950
Query: 2505 APLHTLVMEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRET 2558
A T + V D D G+ + V+D + F + E G++ T L+ E
Sbjct: 951 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
Query: 2559 PAEKVISVRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVV 2616
+ + ++A D G V + V IL P+F +Y + A KGT V
Sbjct: 1011 TT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
Query: 2617 KVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV 2676
+ A+ N I Y+I + +E ++ IN ++GVI L+ E T +V V
Sbjct: 1069 VISAA----AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRV 1119
Query: 2677 DNGS----------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR 2726
S PSK + VY++I P F + FY VSED + T + ++
Sbjct: 1120 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1179
Query: 2727 AEHSGTVLYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCT 2783
A T YS++ P E FV++ +G +K + +++F ++A
Sbjct: 1180 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA--- 1236
Query: 2784 QDDH--EMVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSR 2827
DD+ + DV + V + D + + P + ++ E +PG
Sbjct: 1237 TDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKV 1296
Query: 2828 VIQ 2830
V++
Sbjct: 1297 VVE 1299
Score = 217 bits (552), Expect = 2e-55
Identities = 284/1215 (23%), Positives = 497/1215 (40%), Gaps = 138/1215 (11%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 102 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 161
Query: 1044 KEDAPVGSLVMT-----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIET 1093
E PVG+ + T A D D +G+I Y I+ D + F+I TG I
Sbjct: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 221
Query: 1094 SDRLDRESTSHYWLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME 1150
RL+ E + Y++ + A D+ ++ + ++V D +D P V P +
Sbjct: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
Query: 1151 -------------NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG--- 1185
+P++++ + I+A D D S ++Y I G P+
Sbjct: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
Query: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
FF +HP+T ++ ++R+ + L + + P A + ++ILDEN+ P F
Sbjct: 342 FFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 400
Query: 1246 LQKFYKIRLPEREKPD---RERNARREPLYHVIATDKDEGPNAEISYSIEDG------NE 1296
Y+ + E + PL ++A DKD +D N+
Sbjct: 401 TMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDVPPSGVPTKDPELHLFLND 459
Query: 1297 HGKFFIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKP 1351
+ F +TG+ + + SI A D + + + + + P
Sbjct: 460 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 519
Query: 1352 SLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTI 1411
+ IS++ +T + D V + V + E + ++I G F ++K TG I
Sbjct: 520 TFPEISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 577
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVI 1465
+A ++ Y LTV+A D + V+I+V+ N+ P+F Y + I
Sbjct: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 637
Query: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
E +L + A D+ E + + Y +++ DP + F L TG L + LD E+
Sbjct: 638 SEAMRVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDREST 693
Query: 1526 HQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVT 1585
++ L + D P + A + + V+D ND+AP F + + V QV
Sbjct: 694 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVK 752
Query: 1586 ALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSP 1645
A D D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V ATD
Sbjct: 753 ATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVH 809
Query: 1646 PMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIK 1702
P ++ I V D+ SP FT+ Y+V + E + G+ + + A ++V Y I+
Sbjct: 810 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR 869
Query: 1703 DGNTGDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLV 1753
F ++P +G + ++LD+E P + I GT G++T T +
Sbjct: 870 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 927
Query: 1754 HLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIV 1812
++D ND PVF + Y G+++ A + + T + A DAD A V + V
Sbjct: 928 -VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRV 979
Query: 1813 E----PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868
+ P + F ++ +G + T ++L+ E T+IF V D G P + + +A V +
Sbjct: 980 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKIL 1037
Query: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
V+ + P + + KG V ++A + S ++YSI GN + F
Sbjct: 1038 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFG 1093
Query: 1929 MDYKTGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESH 1976
++ TG + V + R+ Y L V+A + V I +++
Sbjct: 1094 INNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1153
Query: 1977 LKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTS 2029
F + Y V E++ ++ + A + Y ++ P + F + +
Sbjct: 1154 PVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYT 1213
Query: 2030 GVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
G++ T F ++ F V T+++ V V V +Q D + N+P V
Sbjct: 1214 GLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1272
Query: 2090 VKVDTEVGHVI-RYV 2103
K ++ ++ RYV
Sbjct: 1273 EKKIEDLTEILDRYV 1287
Score = 177 bits (449), Expect = 2e-43
Identities = 220/884 (24%), Positives = 369/884 (41%), Gaps = 132/884 (14%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
++RE + YT + A + E V +QV+D ND P F SY V + + S
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 539
Query: 168 IARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAAD 226
+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + AAD
Sbjct: 540 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
Query: 227 RGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQG 284
+ I TV+IE N +P + E+ V ++
Sbjct: 600 NAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 654
Query: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDKGT 343
GD + +I GD R F S+ + +G +D +S Y L + A D G
Sbjct: 655 REGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD-GR 706
Query: 344 PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFK 403
P S+ V V + PV + P N VV +A ++
Sbjct: 707 PDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKATDP 756
Query: 404 STP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKASTK 448
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 757 DAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT 816
Query: 449 VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN--LN 506
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I + +
Sbjct: 817 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 874
Query: 507 HVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL--NN 561
H FA+ FTG +S +LDYE P T + A D Y +AT+T+ +
Sbjct: 875 HF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIVKD 930
Query: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---ELDF 614
+ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 931 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 990
Query: 615 FSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQC 674
F + +SG + IT + T ++ + VA
Sbjct: 991 FEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF--------- 1021
Query: 675 EETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGS 734
+ G M + ++ LH GE IP+F V E G+
Sbjct: 1022 -DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATKGT 1065
Query: 735 SVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY------ 788
V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1066 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
Query: 789 -TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEAT 847
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+AT
Sbjct: 1122 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
Query: 848 DKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
DKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYG 1241
Query: 903 E----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1242 KGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1281
Score = 164 bits (415), Expect = 2e-39
Identities = 187/693 (26%), Positives = 297/693 (42%), Gaps = 106/693 (15%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 196
Query: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 197 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
Query: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
R ++ + + D +D P F +A P T E P +
Sbjct: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 308
Query: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 309 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 369 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 425
Query: 3247 TEVLQVYAASRDIE---------ANAEITYSIISGNEHGKFSIDSKTGA---VFIIENLD 3294
T L++ A +DIE + E+ + N++ ++TG + +++ +D
Sbjct: 426 TSPLRIVALDKDIEDVPPSGVPTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVD 482
Query: 3295 YESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV 3354
E Y ++ A DG S + VN+ V D NDNTP F + +Y + D SV
Sbjct: 483 REEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
I + A DAD SN I Y I+ G QG F I+ G + + ++ Y LTVQA+D
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
Query: 3415 NGSPP--RVNTTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSH 3471
N P R + TV I+V N+ +P F + YS+ I E VG +L L TD +
Sbjct: 600 NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE--- 656
Query: 3472 NGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTY 3530
G + I G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S
Sbjct: 657 -GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT 714
Query: 3531 IDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDN 3588
++I V + + P P S EE + +G++ ATD D + + YSL +N
Sbjct: 715 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNN 773
Query: 3589 LFSVSSTGGKLIAHK-KLDIGQYL-LNVSVTDG 3619
LF ++S G A K ++ Y L V TDG
Sbjct: 774 LFRITSNGSIYTAVKLNREVRDYYELVVVATDG 806
Score = 138 bits (347), Expect = 1e-31
Identities = 152/593 (25%), Positives = 257/593 (43%), Gaps = 71/593 (11%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV---------IT 3356
+A L A +++ + D N+ +P F+ +Y I E A + ++ +
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3357 VMADDAD----GPS-----NSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYT 3407
++A D D PS + +H + D + T + + + + +DRE YT
Sbjct: 431 IVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
Query: 3408 LTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDE 3467
++ A D VNI V D NDN P F +Y V + + G SV+QL D
Sbjct: 491 FSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
Query: 3468 DSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QL 3525
D NG + I+ G G++ + ++ Y L V+ ADN P +
Sbjct: 549 DEGSNG-EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
Query: 3526 SSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL-- 3582
+S+ + I V+ + P P ++ E G V+ + ATD++ D++TY++
Sbjct: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIEN 666
Query: 3583 -DPQMDNLFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
DPQ +F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 667 GDPQ--RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 717
Score = 126 bits (317), Expect = 4e-28
Identities = 141/560 (25%), Positives = 246/560 (43%), Gaps = 62/560 (11%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 167 SIA---------RVSATDADIGT---------NGEFYYSFKDRTDMFAIHPT--SGVIVL 206
+I+ R+ A D DI + E + D T +F + T + + L
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
Query: 207 TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSP 264
+D E + Y I A D G+ + V+I+ AN+ P ++
Sbjct: 478 LQPVDREEQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDV 528
Query: 265 SEL-DRDPAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKV 317
D P +++ T D D+G+NG+I +V GD + T + PG V
Sbjct: 529 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----V 583
Query: 318 KAIGGIDWDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAE 375
+ I G Y LT+QA D P + +S+ +++ P P +F + +Y E
Sbjct: 584 EMIVGRT-------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 636
Query: 376 ISEFAPPNTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHF 434
ISE ++ ++A + Y ++ + F+L+ TG++++ + + R+ +
Sbjct: 637 ISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 696
Query: 435 ELEVTTSDRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP 490
L +T SD + ++ V + V N N P F + V + A DP
Sbjct: 697 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 756
Query: 491 DEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
D G NG V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R
Sbjct: 757 DAGINGQVHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHS 813
Query: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGN 610
LA I + +++DN+P+F + +L G I + A D D V Y+I +
Sbjct: 814 TLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 872
Query: 611 ELDFFSLNPNSGVLSLKRSL 630
FF+L+P +G LSL RSL
Sbjct: 873 VKHFFALHPFTGELSLLRSL 892
Score = 118 bits (295), Expect = 2e-25
Identities = 132/499 (26%), Positives = 222/499 (44%), Gaps = 39/499 (7%)
Query: 88 YILGDFCFLRIRTKGGN--TAI-LNREVKDHYTLIVKALEKNTNVEART-KVRVQVLDTN 143
Y LG+F L T G+ TA+ LNREV+D+Y L+V A + + T + ++VLD +
Sbjct: 766 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
Query: 144 DLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGV 203
D P+F+ ++Y+V + EN T+I ++ A D D+G N + + FA+HP +G
Sbjct: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
Query: 204 IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPV----ITA 259
+ L LDY E I +YG+ +A +TV ++ N+ PV I
Sbjct: 886 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYK 944
Query: 260 VTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
++P + P I TV D G AS D + QF S +E +
Sbjct: 945 GMVAPDAVKGTP---ITTVYAEDADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRV 1000
Query: 320 IGGIDWDSHPFG-YNLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPV-KFEKDVYR-AE 375
I ++ + P + L + A D G P SS V I V P G + +F ++ YR
Sbjct: 1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP----GEIPRFTQEEYRPPP 1056
Query: 376 ISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEP---------V 426
+SE A T V ++ A + Y S + F +N TG+I + P V
Sbjct: 1057 VSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1116
Query: 427 KRQQAAHFEL---EVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
R QA E+ + + + KV +++ N++PP F + Y E+ + T+V+
Sbjct: 1117 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
Query: 484 SLSAVDPDEGENGYVTYSI----ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539
+ A D D G + Y + F ++ +TG + T+ L + + + ++
Sbjct: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA-MLFHNMRRSYFKFQVI 1235
Query: 540 AS-DWGLPYRREVEVLATI 557
A+ D+G + +VL ++
Sbjct: 1236 ATDDYGKGLSGKADVLVSV 1254
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 623 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 677
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 678 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 727
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 728 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 781
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 782 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 836
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 888
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 889 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 945
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 946 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 1004
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 1005 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1064
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1065 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1119
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1120 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1233
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1234 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1277
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 303 bits (776), Expect = 3e-81
Identities = 320/1136 (28%), Positives = 505/1136 (44%), Gaps = 102/1136 (8%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2532 -VNDFAKDRFY-INERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDD 2589
N DR +NER R T + V L D G C V++ +
Sbjct: 192 QYNPDDPDRAQNLNER----------RTTTTTLTVDV-LDGDDLGPMFLPC---VLVPNT 237
Query: 2590 NDNAP-QFRATKYEVNIGSSAAKGTSVVKVLASDADEG-----SNADITYAIEADS-ESV 2642
D P ++A E+ + A D D I Y+I + E
Sbjct: 238 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
Query: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DNGSPSKESVVLVYVKILPPEMQLP 2701
++ + ++ E + ++ F ++A DNG P L +++IL Q P
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSP 356
Query: 2702 KFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKG----NTPES----NRDESFVI 2753
F+ P Y + E P+G I S + +L K PE N S
Sbjct: 357 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 416
Query: 2754 DRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFE 2810
Q+G L L + +D E + Y FSI A + E V V+IQV DANDN+P F
Sbjct: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI---VNIQVMDANDNTPTFP 473
Query: 2811 SSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWIT 2870
Y+ ++ ++ G VIQ+ A DAD G+NG++ Y + V F IN TG IT
Sbjct: 474 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI----LVGAQGDFIINKTTGLIT 529
Query: 2871 TLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTV 2927
++ Y + V A+D+ E+ T ++V + N SPPRF +Y +
Sbjct: 530 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEI 588
Query: 2928 SEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDRE 2987
SE G V+ L TD + + I TY I GDP F + + + + K LDRE
Sbjct: 589 SEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQRVFNLS--ETTGILTLGKALDRE 642
Query: 2988 KRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
D Y+L ITA+DG +S A V + V D NDN+PV + L + + + Q+
Sbjct: 643 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 702
Query: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG-- 3103
ATD D N ++ Y+ LG+ F++ G + T+ L+RE + Y L+V ATDG
Sbjct: 703 KATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVH 760
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS 3163
R ++ + + D++DN+P F+ Y + V EN GT + +++A D D G N + Y
Sbjct: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 818
Query: 3164 L-IDSADGQFSINELSGIIQLEKPLDREL----QAVYTLSLKAVD-QGLPRRLTATGTVI 3217
+ F+++ +G + L + LD E +A T ++A D G AT TVI
Sbjct: 819 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
Query: 3218 VSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA--NAEITYSIISGN-- 3273
V D+ND PPVF R Y V+ D + GT + VYA D + + Y +
Sbjct: 879 VK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
Query: 3274 -EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNT 3332
F ++ +G V NL+ E + + L V A D G P +S ATV + V +
Sbjct: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-I 995
Query: 3333 PVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEV 3392
P F+Q+ Y + + +++ V++ A N I YSI+ GN+ +F I+ + G +
Sbjct: 996 PRFTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTFGINNITGVI 1052
Query: 3393 KVTKLLDRETISGYTLTVQA-------SDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNY 3445
V LD ET + Y L VQA ++ P + NT V I++ D N++ PVF + Y
Sbjct: 1053 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1112
Query: 3446 SVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDE--KAFEVNP-QGVLLTSSA 3502
+ E+ + SVL++ TD+D+ + + I+ E + F V G++ T+
Sbjct: 1113 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1172
Query: 3503 IKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYIDIRVIEESIYPPAILPLEI 3550
+ ++ QV D +GK +S + +D++VI ++ PP ++ +I
Sbjct: 1173 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV-PPTLVEKKI 1227
Score = 296 bits (758), Expect = 3e-79
Identities = 319/1203 (26%), Positives = 525/1203 (43%), Gaps = 134/1203 (11%)
Query: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSIV 862
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 863 TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVND 922
+ D + A+ L+ +L ++ D P V+V + +
Sbjct: 193 YNPDD---------PDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD---C 240
Query: 923 NPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL-----GQSGQVRYSLL----DHGEGN 973
P T+ ++ E+L V ++A D D + YS+L +
Sbjct: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Query: 974 FDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKGKPVSLSSTCYVEVEVVDVNENLHPP 1032
F + + + +++ ++ + Q ++L ++A +D G P+ + ++E+ ++EN P
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEI----LDENNQSP 356
Query: 1033 VFSSFVEKGTVKEDAPVGSLV---------MTVSAHDEDAR--RDGEIRYSIRDGSGVGV 1081
F+ +G + E APVG+ + + + A D+D +D E+ + D + V
Sbjct: 357 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 416
Query: 1082 FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSE 1141
T + +DRE Y ++ A D V S + + I+V D NDN P E
Sbjct: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 474
Query: 1142 PVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSR 1201
Y + + SV+Q+ A D D SN ++ Y+I G QG F I+ TGLI T +
Sbjct: 475 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI-TIAP 532
Query: 1202 KLDREQQDEHILEVTVTDNGSPP--KSTIARVIVKIL-DENDNKPQFLQKFYKIRLPERE 1258
++ + L V DN P +++I V +++L N + P+F Q Y + + E
Sbjct: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
Query: 1259 KPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS-SKRFSAA 1317
+ L ++ ATD++ I+Y+IE+G+ F + TG+++ K
Sbjct: 593 RVG-------AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 642
Query: 1318 GEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPKPSLEPISFEESFFTFTVMESDPVAH 1375
+ I +GRP +ST ++I ++ P +P +V+E + A
Sbjct: 643 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR----NLSVVEEEANAF 698
Query: 1376 MIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG 1434
+ V + +P GI + GN+++ F + G+I A L+ E + Y L V ATDG
Sbjct: 699 VGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDG 757
Query: 1435 TT----TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI 1490
+ LT + IKV+D +D+ P F+ S Y V++ E+ T ILQI A D D +
Sbjct: 758 AVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS 816
Query: 1491 YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV--HQHTLTVMVRDQDV--PVKRNFA 1546
Y + R P F L P TG L LD+EA + ++T +V D+ + A
Sbjct: 817 YRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 873
Query: 1547 RIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKG--KNAEVLYSIESG 1604
+ V V D ND+ P F+ YKG V A G+ + V A D D + V Y ++
Sbjct: 874 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 933
Query: 1605 NI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661
+ F ++ G + T L+ + L+V A D G P MS +V+I V +
Sbjct: 934 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV-LHP 992
Query: 1662 NASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-QSSVVYEIKDGNTGDAFDINPHSGTI 1719
P+FT +EY +SE + G+ VG+++A + S+VY I GN D F IN +G I
Sbjct: 993 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1052
Query: 1720 ITQKALDFETLPIYTLIIQGTNM---------AGLSTNTTVLVHLQDENDNAPVFMQAEY 1770
LD+ET Y L +Q ++ S V + +QDEN++ PVF + Y
Sbjct: 1053 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1112
Query: 1771 TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV---HTYFAIDSSTG 1827
G +SE A + + VL ++A D D + +++ Y ++ P + F +++ TG
Sbjct: 1113 IGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1165
Query: 1828 AIHTVLSLDYEETSIFHFTVQVHD------MGTPRLFAEYAANVTVHVIDINDCPPVFAK 1881
I T + S F F V D G + + + VI N P + K
Sbjct: 1166 LIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEK 1225
Query: 1882 PLYEASLLLPTY-----KGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM-DYKTGA 1935
+ + + +L Y G KV+ + SI G+ FS+ DY
Sbjct: 1226 KIEDLTEILDRYVQEQIPGAKVV---------------VESIGARRHGDAFSLEDYTKCD 1270
Query: 1936 LTV 1938
LTV
Sbjct: 1271 LTV 1273
Score = 294 bits (752), Expect = 2e-78
Identities = 304/1140 (26%), Positives = 490/1140 (42%), Gaps = 108/1140 (9%)
Query: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
Query: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELD 2144
V T VG I A D D G NG++ Y + Q P + E
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI-------QYNPDDPDRAQNLNERR 208
Query: 2145 TLNKEYLVTVVAKDGGNPAFSAEVIVPIT------VMNKAMPVFEKPFYSAEIAESIQVH 2198
T V V+ D P F V+VP T A+P P E I V
Sbjct: 209 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP----EELNPIIVT 264
Query: 2199 SPVVHVQAN-----SPEGLKVFYSITDGDPFSQ---FTINFNTGVINVIAPLDFEAHPAY 2250
P+ + + + + YSI G P F ++ T ++++ P++ + H +
Sbjct: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
Query: 2251 KLSIRATD-------SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG---- 2299
L I+A + G H E+ D N+ P F SY + E++ +G
Sbjct: 325 DLVIKAEQDNGHPLPAFAGLHIEIL------DENNQSPYFTMPSYQGYILESAPVGATIS 378
Query: 2300 -----TSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR 2354
TS +++ A D D E + +F N S T ++LL+ +D E+ +
Sbjct: 379 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 438
Query: 2355 QHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKA 2414
+T + A DG S VIV + V D NDN P F + Y+ + G V + A
Sbjct: 439 TYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 496
Query: 2415 YDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV--- 2471
DAD ++ Y IL G F+I+ TG+IT++ + Y+L + +D
Sbjct: 497 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
Query: 2472 --FRSSTQVHVTVIGGNLHS-PAFLQNEYEVELAENAPLHTLVMEVKTTD--GDSGIYGH 2526
S V++ V+ N S P F Q Y +E++E + +++ ++ TD GDS
Sbjct: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS----- 610
Query: 2527 VTYHIVNDFAKDRFYINERGQIFTLEK-LDRETPAEKVISVRLMAKDAGGKVAFCTVNVI 2585
+TY I N + F ++E I TL K LDRE+ ++ I + + + TVN++
Sbjct: 611 ITYAIENGDPQRVFNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIV 669
Query: 2586 LTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKEN 2645
+TD NDNAP F V +V A+D D G N + Y++ N
Sbjct: 670 VTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNN 724
Query: 2646 LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSE 2705
L +G I T L +++ V A D + S + + +K+L + P F+
Sbjct: 725 LFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 784
Query: 2706 PFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS 2765
YT V E++P GT I I A+ + +PE F + +G L L +S
Sbjct: 785 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK--HFFALHPFTGELSLLRS 842
Query: 2766 LDHETTKWYQFSI--LARCTQDDHEMVASV-DVSIQVKDANDNSPVFESSPYEAFIVENL 2822
LD+E + SI L M + V++ VKD ND PVF Y+ + +
Sbjct: 843 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 902
Query: 2823 PGGSRVIQIRASDADSG--TNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR 2880
G+ + + A DAD +V Y +D Q F + ++G + T L+ E
Sbjct: 903 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 962
Query: 2881 DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYK-GTVSEDDPQGGVIAI 2939
+++ VVA D GE + +SS+A V + V + PRFT E Y+ VSE +G ++ +
Sbjct: 963 TIFKLVVVAFDDGEPV-MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGV 1020
Query: 2940 LSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITAT 2999
+S + IN+ + Y I G+ F + I +YV PLD E R +Y+L + A
Sbjct: 1021 IS-----AAAINQSIVYSIVSGNEEDTFGINNITG--VIYVNGPLDYETRTSYVLRVQAD 1073
Query: 3000 D----------GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATD 3049
+ S+ A V +++ D N++ PV +K Y + ED ++++ ATD
Sbjct: 1074 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1133
Query: 3050 ADIRSNAEITYTL----LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
D + + + Y L + G E F + TG +KT+ ++ + V ATD G+
Sbjct: 1134 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1193
Score = 284 bits (726), Expect = 2e-75
Identities = 274/1027 (26%), Positives = 455/1027 (44%), Gaps = 109/1027 (10%)
Query: 765 FMIDMETGMLKILSPLDRETTDKYTLNITV-YDLGIPQKAAWRLLHVVVVDANDNPPEFL 823
F + T L +L P++R+ K+ L I D G P A + LH+ ++D N+ P F
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFT 359
Query: 824 QESYFVEVSEDKEVHSEI---------IQVEATDKDL----GPNGHVTYSIVTDTDTFSI 870
SY + E V + I +++ A DKD+ P H+ + T T +
Sbjct: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419
Query: 871 DSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPP 930
+T + + +P+DRE Q ++ I A D +E V+V + + D NDN PTF
Sbjct: 420 TGITRYLTLLQPVDREEQQTYTFSITAFDGVQES----EPVIVNIQVMDANDNTPTFPEI 475
Query: 931 NYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD 990
+Y V V D+ G ++ L A D D G +G++ Y +L +G+F ++K +G + I ++
Sbjct: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 535
Query: 991 FEKKQVYNLTVRAKDKGKPVS-LSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV 1049
+ Y LTV+A D P +S C V +EV+ N N PP F + + E V
Sbjct: 536 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRV 594
Query: 1050 GSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109
G++++ + A D R I Y+I +G VF + E TG++ LDREST Y L +
Sbjct: 595 GAVLLNLQATD---REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 651
Query: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV---------Q 1160
A+D G +S + I V DVNDNA PV+ P + P+++SVV Q
Sbjct: 652 TASD-GRPDGTSTATVNIVVTDVNDNA-----PVFDPYL----PRNLSVVEEEANAFVGQ 701
Query: 1161 IEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN 1220
++A DPD+ N ++ Y + GN F I + T KL+RE +D + L V TD
Sbjct: 702 VKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYELVVVATDG 757
Query: 1221 GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKD 1280
P+ + + +K+LD +DN P F Y + L E P + + A D D
Sbjct: 758 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV-LVEENLP------AGTTILQIEAKDVD 810
Query: 1281 EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYD---ILSIKAVD--NGR 1332
G N +SY I F + P TG +S R + A + + ++A D
Sbjct: 811 LGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 868
Query: 1333 PQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL--- 1389
P +T + ++ ++ P + + ++ P+ + +PPG+P
Sbjct: 869 PPGIATVTVIVKDMNDYPPVFSKRIY-KGMVAPDAVKGTPIT-TVYAEDADPPGLPASRV 926
Query: 1390 ---WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-TDGTTTILTQVFIK 1445
D+ S F+V++ +G +I L+ E + + L V A DG + + +K
Sbjct: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
Query: 1446 VIDTNDHR-PQFSTSKYEVVIPEDTAPE---TEILQISAVDQDEKNKLIYTLQSSRDPLS 1501
++ + P+F+ +Y + A + ++ +A++Q ++Y++ S +
Sbjct: 987 ILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ----SIVYSIVSGNEE-- 1040
Query: 1502 LKKFRLDPATGSLYTSEKLDHEA-------VHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
F ++ TG +Y + LD+E V +L V++ + VP K N A++ + + D
Sbjct: 1041 -DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1099
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLY-----SIESGNIGNS 1609
N+H P F Y G V E A + + VL+V A DKD G + + Y I+ G G
Sbjct: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1157
Query: 1610 FMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV-------TIADN 1662
F+++ G IKTA ++ + V ATD +S V + V I N
Sbjct: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
Query: 1663 ASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQ 1722
P K ++ + I VV I GDAF + ++ +T
Sbjct: 1218 VPPTLVEK----KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTV 1273
Query: 1723 KALDFET 1729
A+D +T
Sbjct: 1274 YAIDPQT 1280
Score = 279 bits (714), Expect = 4e-74
Identities = 301/1136 (26%), Positives = 500/1136 (44%), Gaps = 135/1136 (11%)
Query: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
A D D+G NG + Y I P + +T+ L +++ D G
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLD--------GDDLGPM 227
Query: 547 YRREVEVLATITLNNLNDNTPL-FEKINCEGTIPRDLGVGEQITTVSAIDAD-------E 598
+ L + + N D PL ++ E P +L + AID D +
Sbjct: 228 F------LPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSD 281
Query: 599 LQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
+ Y I G D FF ++P + LSL + K L I A
Sbjct: 282 RPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK---FDLVIKAEQDNGHPL 338
Query: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
P + + + ++L N + +F S +I +
Sbjct: 339 PAFAGLHI----------------------EILDENN-------QSPYFTMPSYQGYILE 369
Query: 716 FRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGM- 773
+ P G + ++ + S + I D++ + +L + N+ + +TG+
Sbjct: 370 ---SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGIT 423
Query: 774 --LKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEV 831
L +L P+DRE YT +IT +D G+ Q++ ++++ V+DANDN P F + SY V V
Sbjct: 424 RYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPVIVNIQVMDANDNTPTFPEISYDVYV 481
Query: 832 SEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD-TFSIDSVTGVVNIARPLDRELQHE 890
D +IQ+ A D D G NG +TY I+ F I+ TG++ IA ++ +
Sbjct: 482 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 541
Query: 891 HSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW 948
++L ++A D A E TV ++V L N +PP F Y +++ E + G V++
Sbjct: 542 YALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 600
Query: 949 LEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDK 1006
L+A D + + Y+ +++G+ F++ + +G + + + LD E Y L + A D
Sbjct: 601 LQATD---REGDSITYA-IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD- 655
Query: 1007 GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRD 1066
G+P +ST V + V DVN+N PVF ++ + + + V V A D DA +
Sbjct: 656 GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
Query: 1067 GEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126
G++ YS+ G+ +F+I G I T+ +L+RE +Y L V ATD V P S + +
Sbjct: 713 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 769
Query: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGF 1186
I+V D++DN+P + Y + EN P +++QIEA D D +N + Y+I S + F
Sbjct: 770 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 827
Query: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN-----GSPPKSTIARVIVKILDENDN 1241
F++HP TG ++ R LD E + +T G+ P IA V V + D ND
Sbjct: 828 FALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDY 885
Query: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEG--PNAEISYSIEDGN---E 1296
P F ++ YK + PD + P+ V A D D P + + Y ++D
Sbjct: 886 PPVFSKRIYKGMV----APDAVKGT---PITTVYAEDADPPGLPASRVRYRVDDVQFPYP 938
Query: 1297 HGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLE 1354
F +E +G V ++ I L + A D+G P SS+ + I + P
Sbjct: 939 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---HPGEI 995
Query: 1355 PISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVA 1414
P +E + V E M+GVIS + + I GN + F ++ TG I V
Sbjct: 996 PRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1055
Query: 1415 KPLDAEQKSNYNLTVEATDGTTTIL-----------TQVFIKVIDTNDHRPQFSTSKYEV 1463
PLD E +++Y L V+A D +L +V+I++ D N+H P F Y
Sbjct: 1056 GPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1114
Query: 1464 VIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKK--FRLDPATGSLYTS 1517
+ ED T +L++ A D+D N + + P+ K F ++ TG + T+
Sbjct: 1115 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1170
Score = 258 bits (658), Expect = 1e-67
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
Query: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
Query: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 421 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 476
Query: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 535
Query: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
+G ++L + A D A
Sbjct: 536 MIVGRT---YALTVQAADN---------------------------------------AP 553
Query: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 554 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 610
Query: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 611 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 669
Query: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 670 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 726
Query: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 727 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 783
Query: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 840
Query: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 895
Query: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
Query: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1015
Query: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1016 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1070
Query: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1122
Query: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1123 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1169
Score = 243 bits (621), Expect = 2e-63
Identities = 308/1189 (25%), Positives = 499/1189 (41%), Gaps = 164/1189 (13%)
Query: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
Query: 175 DADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGS 234
D D G NG+ Y + D R L + L D +
Sbjct: 178 DIDDGPNGQIEYVIQYNPDD------------PDRAQNLNERRTTTTTLTVD----VLDG 221
Query: 235 SGISSMAKLTVHIEQANECAPVITAVTL----SPSELDRDPAYAIVTVDDCDQGANGDIA 290
+ M V + +C P+ + +P EL +P + DQ N
Sbjct: 222 DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL--NPIIVTPPIQAIDQDRNIQPP 279
Query: 291 S------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA-KDKGT 343
S SI+ G R P + E + + ++ D H ++L ++A +D G
Sbjct: 280 SDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPVNRDFHQ-KFDLVIKAEQDNGH 336
Query: 344 P-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVF 402
P P F+ +H+ F Y+ I E AP + ++ S LR V
Sbjct: 337 PLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAPVGATI--SDSLNLTSPLRIVA 391
Query: 403 -------KSTPGKAKFSLNYN----------TGLISILEPVKRQQAAHFELEVTTSDRKA 445
P F +Y T +++L+PV R++ + +T D
Sbjct: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 451
Query: 446 STK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V ++V+ AN N P F + +Y ++ G +V+ L+AVD DEG NG +TY I
Sbjct: 452 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 511
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
F I+ TG ++ + ++ ++ R Y L ++A+D P R + T+ + L
Sbjct: 512 LVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAADNAPPAERR-NSICTVYIEVL 569
Query: 563 ---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNP 619
N + P F ++ I + VG + + A D E + Y IE G+ F+L+
Sbjct: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSE 628
Query: 620 NSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PLYINITVAASHKLVNLQCEETG 678
+G+L+L ++L + L ITA+DG T +NI V
Sbjct: 629 TTGILTLGKALD---RESTDRYILIITASDGRPDGTSTATVNIVVT-------------- 671
Query: 679 VAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIF 738
VN + P F LP + V E + + V
Sbjct: 672 -----------------------------DVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQ 701
Query: 739 MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLG 798
+ +TD D G NG++ Y++ GN ++ F I G + L+RE D Y L + D
Sbjct: 702 VKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGA 758
Query: 799 IPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVT 858
+ + + L + V+D +DN P F +Y V V E+ + I+Q+EA D DLG N V+
Sbjct: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
Query: 859 YSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSLK--IEARDQAREEPQLFSTVV 912
Y I + F++ TG +++ R LD E E S+ +EA D P +TV
Sbjct: 817 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 876
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWLEAHDPDLGQSGQVRYSLLD-- 968
V V +D+ND PP F Y+ V D +GT I ++ E DP + +VRY + D
Sbjct: 877 VIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
Query: 969 --HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVN 1026
+ F+V++ SG V L+ E ++ L V A D G+PV +SS+ V++ V
Sbjct: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV---- 989
Query: 1027 ENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVF 1082
LHP F ++ V E A G++V +SA A + I YSI G+ F
Sbjct: 990 --LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1043
Query: 1083 KIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV-------PLSSFIEIYIEVEDVNDN 1135
I TGVI + LD E+ + Y L V A VV S+ ++YIE++D N++
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 1136 APQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKI----TSGNPQGFFSIHP 1191
P + Y + E++ SV++++A D D+ + + Y++ +GF +
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV-VET 1162
Query: 1192 KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
TGLI T+ ++ +V TD+ S A V+V ++++ D
Sbjct: 1163 YTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 240 bits (613), Expect = 2e-62
Identities = 278/1117 (24%), Positives = 468/1117 (41%), Gaps = 119/1117 (10%)
Query: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 968 DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNE 1027
+ + D D+ Q L+ + LTV D + C + V
Sbjct: 193 YNPD---DPDR-------AQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL----VPNTR 238
Query: 1028 NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR------RDGEIRYSIRDGSGVGV 1081
+ P + + + + E+ + + A D+D R G I YSI G+
Sbjct: 239 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDY 297
Query: 1082 ---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQ 1138
F + T + + ++R+ + L + A PL +F ++IE+ D N+ +P
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
Query: 1139 TSEPVYYPEIMENSPKDVSV---------VQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
+ P Y I+E++P ++ ++I A D D + + F++
Sbjct: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
Query: 1190 HPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
+TG+ T + +DRE+Q + +T D + I V ++++D NDN P F +
Sbjct: 418 -TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPE 474
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
Y + + +P + + + A D DEG N EI+Y I G + G F I TG
Sbjct: 475 ISYDVYVYTDMRPG-------DSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTG 526
Query: 1308 VVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPISFEESFF 1363
+++ G L+++A DN P +++S ++IE + P + P F + +
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL--PPNNQSPPRFPQLMY 584
Query: 1364 TFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422
+ + E+ V A ++ + + + G + + I G+ F++ + TG + + K LD E
Sbjct: 585 SLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 644
Query: 1423 SNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISA 1480
Y L + A+DG T V I V D ND+ P F + + + Q+ A
Sbjct: 645 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 704
Query: 1481 VDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD 1538
D D ++ Y+L + + FR+ + GS+YT+ KL+ E + L V+ D
Sbjct: 705 TDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGA 758
Query: 1539 VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVL 1598
V + + + + V D +D++P FT S+Y V E+ G+ +LQ+ A D D G N V
Sbjct: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
Query: 1599 YSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQAEYDLMVKATDKGSPPMSEITSVR 1654
Y I S + + F + P G + + LD +A +V+A D I +V
Sbjct: 817 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 876
Query: 1655 IFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS-------QSSVVYEIKDGN-- 1705
+ V ++ P F+ + Y ++ G+ + V A S V Y + D
Sbjct: 877 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
Query: 1706 -TGDAFDINPHSGTIITQKALDFETLPIYTLII----QGTNMAGLSTNTTVLVHLQDEND 1760
F++ SG +IT+ L+ E I+ L++ G + S +LV E
Sbjct: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-- 994
Query: 1761 NAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTY 1819
P F Q EY +SE A+ ++V VI AA N +VY IV +
Sbjct: 995 -IPRFTQEEYRPPPVSELATKGTMV-------GVISAAAI----NQSIVYSIVSGNEEDT 1042
Query: 1820 FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL-----FAEYAANVTVHVIDIND 1874
F I++ TG I+ LDYE + + VQ + A V + + D N+
Sbjct: 1043 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
Query: 1875 CPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSI--------TEGNIGEK 1926
PPVF K Y + V+ V ATD D+ +S + Y + EG + E
Sbjct: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
Query: 1927 FSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
++ KT L RS ++ V A+D GL+
Sbjct: 1163 YTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1196
Score = 235 bits (600), Expect = 7e-61
Identities = 290/1147 (25%), Positives = 489/1147 (42%), Gaps = 163/1147 (14%)
Query: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNP 1183
E+ I V D NDN+P YY + E +P V F D+ + D P
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATD------IDDGP 183
Query: 1184 QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD-----NGSPPKSTIARVIVKILDE 1238
G Q E++++ D N + ++T + V +LD
Sbjct: 184 NG----------------------QIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG 221
Query: 1239 NDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAE 1286
+D P FL Y+ +PE P+ P I D++ P ++
Sbjct: 222 DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSD 281
Query: 1287 ---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAVDNGRPQK 1335
I YSI G ++ +FF + P+T +S ++ F ++D++ DNG P
Sbjct: 282 RPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQDNGHP-L 338
Query: 1336 SSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVISVE----- 1383
+ LHIE + + PS + E + T+ +S + + +++++
Sbjct: 339 PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 398
Query: 1384 --PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEATDGT-TTI 1438
P + L+ + +Y S F V + T + + +P+D E++ Y ++ A DG +
Sbjct: 399 TKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 454
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSS 1496
V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++ Y +
Sbjct: 455 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 514
Query: 1497 RDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVS--- 1553
+ F ++ TG + + ++ + LTV D P +R + V +
Sbjct: 515 ----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 570
Query: 1554 DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMID 1613
N P F Y + E+ VG+V+L + A D++ + Y+IE+G+ F +
Sbjct: 571 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 627
Query: 1614 PVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKF---TSK 1670
G + K LDR + Y L++ A+D G P + +V I VT ++ +P F +
Sbjct: 628 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPR 686
Query: 1671 EYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKAL 1725
SV E +FVG V A V Y + GN + F I +G+I T L
Sbjct: 687 NLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKL 740
Query: 1726 DFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSV 1783
+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E+ +
Sbjct: 741 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
Query: 1784 VLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE----E 1839
+L I A D D +N + Y I P V +FA+ TG + + SLDYE +
Sbjct: 801 ILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
Query: 1840 TSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKV 1898
+ F V+ D+ GT A VTV V D+ND PPVF+K +Y+ + KG +
Sbjct: 852 EASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 908
Query: 1899 ITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQLRSRYELT 1951
TV A DAD S++ Y + + F ++ +G + V + + ++L
Sbjct: 909 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 968
Query: 1952 VRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAVITAIGNP 2007
V A D + +VKI V E +FTQ+ Y V E +T+ + VI+A
Sbjct: 969 VVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAA-- 1025
Query: 2008 INEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDVVVEVTEE 2056
IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +VV+
Sbjct: 1026 INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRV 1084
Query: 2057 HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEV 2116
S A V ++ ++D+N++ PVF Y V D + + V A D+D+G +
Sbjct: 1085 PSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1142
Query: 2117 HYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPAFSAEVIV 2170
Y L KE E F + + +K + + Y V+A D S + V
Sbjct: 1143 AYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1201
Query: 2171 PITVMNK 2177
++V+N+
Sbjct: 1202 LVSVVNQ 1208
Score = 230 bits (586), Expect = 3e-59
Identities = 284/1181 (24%), Positives = 485/1181 (41%), Gaps = 164/1181 (13%)
Query: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
Query: 1811 IVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQV---HDMGTPRLFAEYAANVTV 1867
I Y D +L+ T+ TV V D+G L V
Sbjct: 191 I------QYNPDDPDRAQ-----NLNERRTTTTTLTVDVLDGDDLGPMFL-------PCV 232
Query: 1868 HVIDINDCPPVFAKPLYEAS---LLLPTYKGVKVIT--VNATDADS-----SAFSQLIYS 1917
V + DC P+ Y+A+ L P ++T + A D D S ++YS
Sbjct: 233 LVPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYS 288
Query: 1918 ITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDGR------FAGLTSVK 1966
I G + F M +T L++ +++L ++A FAGL
Sbjct: 289 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---H 345
Query: 1967 INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN----EPLFYHILNPDRR 2022
I + + FT Y + E++ T++ + +P+ + +P+
Sbjct: 346 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 405
Query: 2023 FKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---TEEHKPSAVAHVVVKV 2069
++ + V + T T P DRE+Q+ + + +E +P V+V +
Sbjct: 406 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP-----VIVNI 460
Query: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129
V D NDN P F + Y V D G + +TAVD D G NGE+ Y + +
Sbjct: 461 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-------V 513
Query: 2130 GPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSAEVIVPITVM-----N 2176
G G+ + K L T+ + Y +TV A D PA I + + N
Sbjct: 514 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
Query: 2177 KAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVI 2236
++ P F + YS EI+E+++V + ++++QA EG + Y+I +GDP F ++ TG++
Sbjct: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGIL 633
Query: 2237 NVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVF---AQQSYAVTLS 2293
+ LD E+ Y L I A+D + V+I+V D+NDN PVF ++ +V
Sbjct: 634 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
Query: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
EA+ V QV+ATD D+ N + Y + GN ++ F + S+ + + ++ L+ E
Sbjct: 694 EANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSNGSIYTAVK-LNREVR 745
Query: 2354 RQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK 2413
+ + V A DG + S + + + V D++DN P+F Y + E+ P G + ++
Sbjct: 746 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 805
Query: 2414 AYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF- 2472
A D D + Y I S F + TG ++L + P +++ F
Sbjct: 806 AKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 2473 ------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD-SGIYG 2525
V V V N + P F + Y+ +A +A T + V D D G+
Sbjct: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
Query: 2526 HVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC 2580
+ V+D + F + E G++ T L+ E + + ++A D G V
Sbjct: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFDDGEPVMSS 981
Query: 2581 TVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD 2638
+ V IL P+F +Y + A KGT V + A+ N I Y+I +
Sbjct: 982 SATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSG 1037
Query: 2639 SESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS----------PSKESVVL 2688
+E ++ IN ++GVI L+ E T +V V S PSK +
Sbjct: 1038 NE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1092
Query: 2689 VYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGN---TPES 2745
VY++I P F + FY VSED + T + ++A T YS++ P
Sbjct: 1093 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1152
Query: 2746 NRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--EMVASVDVSIQVKDAN 2803
E FV++ +G +K + +++F ++A DD+ + DV + V +
Sbjct: 1153 EGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKGLSGKADVLVSVVNQL 1209
Query: 2804 DNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
D + + P + ++ E +PG V++
Sbjct: 1210 DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1250
Score = 211 bits (538), Expect = 1e-53
Identities = 279/1186 (23%), Positives = 488/1186 (41%), Gaps = 124/1186 (10%)
Query: 998 NLTVRAKDKGKPVSLSSTC--------------YVEVEVVDVNENLHPPVFSSFVEKGTV 1043
N T R D+ P+++ S Y EV +V + N + P F TV
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 1044 KEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDREST 1102
E PVG+ + T + D A I DG +G + I + + L+ T
Sbjct: 157 NELTPVGTTIFTGFSGDNGAT-------DIDDGPNGQIEYVIQYNPDDPDRAQNLNERRT 209
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV--- 1159
+ LTV D L + V + D P T + PE+ +P++++ +
Sbjct: 210 TTTTLTVDVLDGD--DLGPMFLPCVLVPNTRDCRPLTYQAA-IPEL--RTPEELNPIIVT 264
Query: 1160 -QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLITTTSRKLDREQQDE 1210
I+A D D S ++Y I G P+ FF +HP+T ++ ++R+ +
Sbjct: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL-EPVNRDFHQK 323
Query: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD---RERNAR 1267
L + + P A + ++ILDEN+ P F Y+ + E +
Sbjct: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
Query: 1268 REPLYHVIATDKD--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD---- 1321
PL ++A DKD + + E+ + N++ F +TG+ + +
Sbjct: 384 TSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQT 439
Query: 1322 -ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
SI A D + + + + + P+ IS++ +T + D V + V
Sbjct: 440 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DMRPGDSVIQLTAVD 498
Query: 1381 SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT----- 1435
+ E + ++I G F ++K TG I +A ++ Y LTV+A D
Sbjct: 499 ADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER 557
Query: 1436 TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQ 1494
+ V+I+V+ N+ P+F Y + I E +L + A D+ E + + Y ++
Sbjct: 558 RNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIE 616
Query: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
+ DP + F L TG L + LD E+ ++ L + D P + A + + V+D
Sbjct: 617 NG-DP--QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTD 672
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
ND+AP F + + V QV A D D G N +V YS+ GN N F I
Sbjct: 673 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 730
Query: 1615 VLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSV 1674
GSI TA +L+R + Y+L+V ATD P ++ I V D+ SP FT+ Y+V
Sbjct: 731 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 789
Query: 1675 ELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP 1731
+ E + G+ + + A ++V Y I+ F ++P +G + ++LD+E P
Sbjct: 790 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 849
Query: 1732 ---------IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINS 1782
+ I GT G++T T + ++D ND PVF + Y G+++ A +
Sbjct: 850 DQEASITFLVEAFDIYGTMPPGIATVTVI---VKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
Query: 1783 VVLTDRNVPLVIRAADADKDS-NALLVYHIVE----PSVHTYFAIDSSTGAIHTVLSLDY 1837
+ T + A DAD A V + V+ P + F ++ +G + T ++L+
Sbjct: 907 PITT-------VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 959
Query: 1838 EETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVK 1897
E T+IF V D G P + + +A V + V+ + P + + KG
Sbjct: 960 EPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1017
Query: 1898 VITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRAS 1955
V ++A + S ++YSI GN + F ++ TG + V + R+ Y L V+A
Sbjct: 1018 VGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1073
Query: 1956 DGRF----------AGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIG 2005
+ V I +++ F + Y V E++ ++ + A
Sbjct: 1074 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1133
Query: 2006 NPIN--EPLFYHILNPDRR-----FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHK 2058
+ Y ++ P + F + +G++ T F ++ F V T+++
Sbjct: 1134 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYG 1192
Query: 2059 PSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI-RYV 2103
V V V +Q D + N+P V K ++ ++ RYV
Sbjct: 1193 KGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYV 1238
Score = 210 bits (535), Expect = 2e-53
Identities = 282/1104 (25%), Positives = 471/1104 (42%), Gaps = 118/1104 (10%)
Query: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL 780
V E PVG+++ +TD+D G NG++ Y + +D ++
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLN---------- 205
Query: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
+R TT T +TV L L V+V + D P ++ E+ +E++
Sbjct: 206 ERRTT---TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP-LTYQAAIPELRTPEELNPI 261
Query: 841 II--QVEATDKDLG---PNGH--VTYSIVTDTDT-----FSIDSVTGVVNIARPLDRELQ 888
I+ ++A D+D P+ + YSI+ T F + T +++ P++R+
Sbjct: 262 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 321
Query: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI-- 946
+ L I+A F+ + +++ D N+ P F P+Y+ + E P G I
Sbjct: 322 QKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISD 379
Query: 947 -------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFDVDK--LSGAVRIVQQLDFEKKQV 996
+ + A D D+ + L L+ F V + ++ + ++Q +D E++Q
Sbjct: 380 SLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 439
Query: 997 YNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTV 1056
Y ++ A D V S V ++V+D N+N P F V D G V+ +
Sbjct: 440 YTFSITAFD---GVQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQL 494
Query: 1057 SAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG- 1115
+A D D +GEI Y I G+ G F I + TG+I + ++ Y LTV A D
Sbjct: 495 TAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 553
Query: 1116 -VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDK 1173
+S +YIEV N+ + P+ + +Y EI E ++ ++A D + D
Sbjct: 554 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 610
Query: 1174 LMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIV 1233
+ Y I +G+PQ F++ TG++ T + LDRE D +IL +T +D G P ++ A V +
Sbjct: 611 ITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 668
Query: 1234 KILDENDNKPQFLQKFYKIRLPER-EKPDRERNARREPLYHVIATDKDEGPNAEISYSIE 1292
+ D NDN P F LP + E NA + V ATD D G N ++ YS+
Sbjct: 669 VVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL- 719
Query: 1293 DGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKP 1351
GN + F I + ++ + + +Y L + A D + ST L I+ +
Sbjct: 720 -GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 778
Query: 1352 SLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--GIPLWFDITGGNYDSHFDVDKGTG 1409
S P+ F S +T V E+ P I I + G + + I F + TG
Sbjct: 779 S--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTG 835
Query: 1410 TIIVAKPLDAE----QKSNYNLTVEATDGTTTI---LTQVFIKVIDTNDHRPQFSTSKYE 1462
+ + + LD E Q+++ VEA D T+ + V + V D ND+ P FS Y+
Sbjct: 836 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
Query: 1463 VVIPEDTAPETEILQISAVDQD----EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSE 1518
++ D T I + A D D +++ Y + + P F ++ +G + T
Sbjct: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
Query: 1519 KLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK-GRVYESAAV 1577
L+ E L V+ D PV + A + + V + P FT Y+ V E A
Sbjct: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATK 1014
Query: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637
G++V ++A N ++YSI SGN ++F I+ + G I LD + Y L V
Sbjct: 1015 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
Query: 1638 KA-------TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVT 1690
+A + P S V I + +N P F K Y +SE + + V V
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
Query: 1691 AHSQSS----------VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP----IYTLI 1736
A + + ++ IK+G G F + ++G I T A+ F + + +I
Sbjct: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKT--AMLFHNMRRSYFKFQVI 1186
Query: 1737 IQGTNMAGLSTNTTVLVHLQDEND 1760
GLS VLV + ++ D
Sbjct: 1187 ATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 179 bits (453), Expect = 7e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 373 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 429
Query: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 430 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 488
Query: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 489 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
Query: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
AD + I TV+IE N +P + E+ V ++
Sbjct: 549 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 603
Query: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 604 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 655
Query: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
G P S+ V V + PV + P N VV +A ++
Sbjct: 656 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 705
Query: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 706 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
Query: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 766 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 823
Query: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 824 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 879
Query: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 880 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 939
Query: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
F + +SG + IT + T ++ + VA
Sbjct: 940 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 972
Query: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
+ G M + ++ LH GE IP+F V E
Sbjct: 973 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1014
Query: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 1015 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
Query: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
Query: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1190
Query: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 1191 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1232
Score = 169 bits (429), Expect = 4e-41
Identities = 180/649 (27%), Positives = 280/649 (43%), Gaps = 62/649 (9%)
Query: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 3064 GSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDG---GGRFCQASIVLTLEDVND 3120
+ NPD + + L+ L V DG G F +V D
Sbjct: 192 -------QYNPDDPDRAQN--LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 242
Query: 3121 NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRK-----ILYSLIDSADGQ---- 3171
+ A + E P + +QA D D + ILYS++
Sbjct: 243 LT--YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Query: 3172 FSINELSGIIQLEKPLDRELQAVYTLSLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVF 3230
F ++ + + L +P++R+ + L +KA D G P L A + + +LD N+ P F
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILDENNQSPYF 358
Query: 3231 EYREY----------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSI 3280
Y GAT+S+ + + T L++ A +DIE + + + F++
Sbjct: 359 TMPSYQGYILESAPVGATISDSLNL-TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
Query: 3281 DSK--TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQD 3338
T + +++ +D E Y ++ A DG S + VN+ V D NDNTP F +
Sbjct: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEI 475
Query: 3339 TYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLL 3398
+Y + D SVI + A DAD SN I Y I+ G QG F I+ G + + +
Sbjct: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGV 534
Query: 3399 DRETISGYTLTVQASDNGSPP--RVNTTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPV 3455
+ Y LTVQA+DN P R + TV I+V N+ +P F + YS+ I E V
Sbjct: 535 EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 594
Query: 3456 GFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQ 3514
G +L L TD + G + I G+ ++ F ++ G+L A+ R+ D Y+L
Sbjct: 595 GAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
Query: 3515 VKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD- 3573
+ +D G+P +S ++I V + + P P S EE + +G++ ATD D
Sbjct: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 709
Query: 3574 -VYDTLTYSLDPQMDNLFSVSSTGGKLIAHK-KLDIGQYL-LNVSVTDG 3619
+ + YSL +NLF ++S G A K ++ Y L V TDG
Sbjct: 710 GINGQVHYSLG-NFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG 757
Score = 129 bits (324), Expect = 7e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 316 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 375
Query: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 376 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 435
Query: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 436 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 486
Query: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 487 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 541
Query: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 542 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 594
Query: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 654
Query: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 655 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 714
Query: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 715 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 770
Query: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 771 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 830
Query: 618 NPNSGVLSLKRSL 630
+P +G LSL RSL
Sbjct: 831 HPFTGELSLLRSL 843
Score = 126 bits (316), Expect = 6e-28
Identities = 140/578 (24%), Positives = 237/578 (41%), Gaps = 85/578 (14%)
Query: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3159 KILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIV 3218
+I Y + + D DR Q L R T T T+ V
Sbjct: 186 QIEYVIQYNPDDP----------------DRA-------------QNLNERRTTTTTLTV 216
Query: 3219 SVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQVYAASRDI 3259
VLD +D P+F Y A + E + ++ T +Q R+I
Sbjct: 217 DVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 276
Query: 3260 EANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP 3313
+ ++ I YSI+ G F + +T + ++E ++ + ++ L ++A
Sbjct: 277 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 336
Query: 3314 SLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV-----------ITVMADDA 3362
L A +++ + D N+ +P F+ +Y I E A + ++ I + D
Sbjct: 337 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 396
Query: 3363 DGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVN 3422
+ + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 397 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESE 454
Query: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
VNI V D NDN P F +Y V + + G SV+QL D D NG + I+
Sbjct: 455 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG-EITYEILV 513
Query: 3483 GNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYIDIRVIEESI 3540
G G++ + ++ Y L V+ ADN P + +S+ + I V+ +
Sbjct: 514 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
Query: 3541 YPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDNLFSVSSTG 3596
P P ++ E G V+ + ATD++ D++TY++ DPQ +F++S T
Sbjct: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--RVFNLSETT 630
Query: 3597 GKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 631 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 668
Score = 103 bits (256), Expect = 5e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 574 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 628
Query: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 629 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 678
Query: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 679 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 732
Query: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 733 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 787
Query: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 839
Query: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 840 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 896
Query: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 897 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
Query: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1015
Query: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 1016 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1070
Query: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
Query: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 1130 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1184
Query: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 1185 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1228
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 288 bits (738), Expect = 7e-77
Identities = 229/723 (31%), Positives = 349/723 (48%), Gaps = 42/723 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 110 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 165
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 224
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 283
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 284 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 344 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+ + LD
Sbjct: 404 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLD 457
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 517
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
+V ATDAD+G N +I Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 518 MKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN 577
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 578 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 636
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 637 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 3325 VTDINDNTPVFSQDTYTTVISEDAVLEQS-----VITVMADDADGPSNSHIHYSIIDGNQ 3379
V D+NDN PVF Y S + VL + V V+A D D N+ + YSI+ GN
Sbjct: 695 VVDVNDNKPVFIVPPYN--YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 752
Query: 3380 GSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAP 3438
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA
Sbjct: 753 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNAT 812
Query: 3439 VFS 3441
+ +
Sbjct: 813 LIN 815
Score = 256 bits (653), Expect = 5e-67
Identities = 225/814 (27%), Positives = 358/814 (43%), Gaps = 91/814 (11%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 157 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 216 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 275
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 276 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 336 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRI 985
P N V + E++P T I + D D +G+V DH E F + + +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 449
Query: 986 VQQ---LDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
++ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 506
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G +M VSA D D+ + EI Y + F + TG++ +LDRE
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE 565
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 566 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 625
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 626 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 682
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 683 VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP--------GTVVFQVIAVD 734
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRPQK 1335
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 735 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQPD- 792
Query: 1336 SSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG 1395
SL + F +V + + ++ S+E P P
Sbjct: 793 ----------------SLFSVVIVNLFVNESVTNATLINELVRK-SIEAPVTP------- 828
Query: 1396 GNYDSHFDVDKGTGTIIVAKPLDAEQKSNY-NLTVEATDGTTTILTQVFIKVIDTNDHRP 1454
T V+ P S+Y + V A GT T++ +FI + P
Sbjct: 829 -----------NTEIADVSSP-----TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAP 872
Query: 1455 QFSTSKYEVVIPEDTAPETEILQISAVDQDEKNK 1488
++ + E P E Q+ + + +K K
Sbjct: 873 HLKAAQKNMQNSEWATPNPENRQMIMMKKKKKKK 906
Score = 248 bits (634), Expect = 8e-65
Identities = 192/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 390
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 447
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++EN LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 448 FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 507
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ ++ V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 508 PENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKED 566
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y + EN P +V + V
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 627 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 683
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP E+ + S+ G V+ ++ A D D +
Sbjct: 684 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTGMN 740
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 741 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 773
Score = 244 bits (624), Expect = 1e-63
Identities = 205/689 (29%), Positives = 336/689 (48%), Gaps = 47/689 (6%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 139 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 197
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 198 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 257
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 258 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 317
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 318 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 377
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 378 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 429
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 488
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G +++++ A+DADSG N ++ Y L E
Sbjct: 489 KDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE---- 544
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 545 FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 603
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
YK V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 660
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYS---DTIP 3033
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y+ + +
Sbjct: 661 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL 718
Query: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQAV 3092
PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D + +
Sbjct: 719 PSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGL 778
Query: 3093 YHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
+ +LV+A D G S+V+ VN++
Sbjct: 779 HRVLVKANDLGQPDSLFSVVIVNLFVNES 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 318/678 (46%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 210 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 267
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 268 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 383
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 384 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 440
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + + LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 500
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V ATD D GPNAEI+Y + + +F ++ +TG
Sbjct: 501 SFVTVSIPENNSPGIQ-------LMKVSATDADSGPNAEINYLL-GPDAPPEFSLDRRTG 552
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 553 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYKF 609
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 610 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 669
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTS----KYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F YE+V+P T P T +
Sbjct: 670 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVF 728
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 729 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 785
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 786 NDLGQP-DSLFSVVIVNL 802
Score = 214 bits (545), Expect = 2e-54
Identities = 215/707 (30%), Positives = 324/707 (45%), Gaps = 55/707 (7%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 108 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 167
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 168 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 227
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 228 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKE 463
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G + V A
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSAT 523
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS ++ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 524 DADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY+ + EN P H V + TD D G VT I+
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 642
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 643 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 696
Query: 2587 TDDNDNAPQFRATKYEVN---IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVK 2643
D NDN P F Y + + S GT V +V+A D D G NA++ Y+I + +
Sbjct: 697 -DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NTR 753
Query: 2644 ENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
+ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 754 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 800
Score = 196 bits (498), Expect = 4e-49
Identities = 209/763 (27%), Positives = 330/763 (43%), Gaps = 75/763 (9%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 104 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 160
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 221 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 279 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 390
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P +++++SA D D ++ Y L P +F LD TG L +KLD E
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPP----EFSLDRRTGMLTVVKKLDREKED 566
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + YK V E+ V +T
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 627 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 684
Query: 1647 MSEITSVRIFVTIADNASPKF--TSKEYSVEL-SETVSIGSFVGMVTA-----HSQSSVV 1698
S V I V ++ P F YS EL + + G+ V V A + V
Sbjct: 685 RSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 744
Query: 1699 YEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS------------ 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 745 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 1747 ----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILV 847
Score = 191 bits (485), Expect = 1e-47
Identities = 171/654 (26%), Positives = 291/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 200 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 371
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 372 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G +++V ATD+DS PN I+Y + + +
Sbjct: 485 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---A 541
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 542 PPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 601
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y+ + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 602 FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 659
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 660 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 720 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 772
Score = 176 bits (447), Expect = 4e-43
Identities = 155/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 359 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 410
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 411 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLENAAYLDYESTK-E 463
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P ++ V A
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLMKVSA 522
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 523 TDADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 581
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT YK EN+P TV ++ DPD G+N VT SI
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 642 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 698
Query: 563 NDNTPLF----EKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F + E +P G + V A+D D V+Y I GN D F+
Sbjct: 699 NDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 757
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 758 IDQETGNITL 767
Score = 172 bits (437), Expect = 5e-42
Identities = 185/712 (25%), Positives = 319/712 (44%), Gaps = 54/712 (7%)
Query: 1755 LQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEP 1814
++D NDNAP+F I E+++INS A D D N + Y +++
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPA-------AVDPDVGINGVQNYELIKS 213
Query: 1815 -SVHTYFAIDSSTGAIHTVL----SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHV 1869
++ I++ G L LD EE + V+V D G P+ + A + V V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSS--TAILQVSV 271
Query: 1870 IDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE--GNIGEK- 1926
D ND PVF + E S+ G V ++ATDAD +++ +S + NI +
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1927 FSMDYKTGALTVQNTTQLRS--RYELTVRASDGRFAGLTS-VKINVKESKES----HLKF 1979
F ++ TG +T++ ++L V ASDG + V +NV + ++ +++
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 1980 TQDVYS--AVVKENSTEAETLAVITAIGNPINE----PLFYHILNPDRRFKISRTSGVLS 2033
+ + V+ EN +A+IT + F P R + +L
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 451
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
D E + + + + + KP ++ + V+D+NDNAPVF + +
Sbjct: 452 NAAY-LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYL-KEHHEHFQIGP-LGEISLKKQFELDTLNKEYL 2151
G + V+A D DSG N E++Y L + F + G +++ K+ + + +K YL
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDK-YL 569
Query: 2152 VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP 2209
T++AKD G P ++ V V ++++ N PVF Y + E++ H V + P
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 2210 E-GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS---LTGAHA 2265
+ G +++ D FTI+ TGVI D E +Y ++A D + A
Sbjct: 630 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 2266 EVFVDIIVDDINDNPPVFA----QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQ 2321
+V ++++ D+NDN PVF SY + L + GT V QV A D+D+ N + Y
Sbjct: 690 KVTINVV--DVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 746
Query: 2322 MFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP-TLSSDVIVTVDV 2380
+ G +++ D F +D TG I+L+ D H + V+A D G P +L S VIV + V
Sbjct: 747 IVGGNTR--DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432
+ N L + + ++ + P+ T + + +SD K+ + ++G
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPN----TEIADVSSPTSDYVKILVAAVAG 852
Score = 161 bits (407), Expect = 2e-38
Identities = 187/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 391
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP-HSGTIITQ 1722
+++TV + + + T + +V + D N F + P S + +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 451
Query: 1723 KA--LDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
A LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S ++ + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 512 SPGIQLMK-------VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y+ + LP +
Sbjct: 564 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 619
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 620 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 675
Query: 1953 RASDGRFAGLTS---VKINVKESKESHLKFTQDVYS---AVVKENSTEAETLAVITAIGN 2006
+A DG +S V INV + ++ F Y+ +V ++ + + A+ N
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 794
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 795 FSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADV 835
Score = 128 bits (322), Expect = 1e-28
Identities = 164/705 (23%), Positives = 275/705 (39%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 156 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 216 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 270
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 331 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 384
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G +M +SA D D G N + Y + F++D TG ++ + LD E
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREK 564
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F + +P +L +
Sbjct: 565 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 622
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 623 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 679
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ V + K + +N +S
Sbjct: 680 GGRVSRSSSAKVTI--------------NVVDVNDNKPVFIVPPYN-----------YSY 714
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
+P ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 715 ELVLP---STNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 760
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 761 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 801
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 288 bits (738), Expect = 7e-77
Identities = 229/723 (31%), Positives = 349/723 (48%), Gaps = 42/723 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 110 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 165
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 224
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 283
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 284 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 344 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+ + LD
Sbjct: 404 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLD 457
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 517
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
+V ATDAD+G N +I Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 518 MKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN 577
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 578 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 636
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 637 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 3325 VTDINDNTPVFSQDTYTTVISEDAVLEQS-----VITVMADDADGPSNSHIHYSIIDGNQ 3379
V D+NDN PVF Y S + VL + V V+A D D N+ + YSI+ GN
Sbjct: 695 VVDVNDNKPVFIVPPYN--YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 752
Query: 3380 GSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAP 3438
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA
Sbjct: 753 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNAT 812
Query: 3439 VFS 3441
+ +
Sbjct: 813 LIN 815
Score = 256 bits (653), Expect = 5e-67
Identities = 225/814 (27%), Positives = 358/814 (43%), Gaps = 91/814 (11%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 157 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 216 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 275
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 276 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 336 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRI 985
P N V + E++P T I + D D +G+V DH E F + + +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 449
Query: 986 VQQ---LDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
++ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 506
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G +M VSA D D+ + EI Y + F + TG++ +LDRE
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE 565
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 566 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 625
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 626 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 682
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 683 VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP--------GTVVFQVIAVD 734
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRPQK 1335
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 735 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQPD- 792
Query: 1336 SSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG 1395
SL + F +V + + ++ S+E P P
Sbjct: 793 ----------------SLFSVVIVNLFVNESVTNATLINELVRK-SIEAPVTP------- 828
Query: 1396 GNYDSHFDVDKGTGTIIVAKPLDAEQKSNY-NLTVEATDGTTTILTQVFIKVIDTNDHRP 1454
T V+ P S+Y + V A GT T++ +FI + P
Sbjct: 829 -----------NTEIADVSSP-----TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAP 872
Query: 1455 QFSTSKYEVVIPEDTAPETEILQISAVDQDEKNK 1488
++ + E P E Q+ + + +K K
Sbjct: 873 HLKAAQKNMQNSEWATPNPENRQMIMMKKKKKKK 906
Score = 248 bits (634), Expect = 8e-65
Identities = 192/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 390
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 447
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++EN LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 448 FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 507
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ ++ V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 508 PENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKED 566
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y + EN P +V + V
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 627 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 683
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP E+ + S+ G V+ ++ A D D +
Sbjct: 684 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTGMN 740
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 741 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 773
Score = 244 bits (624), Expect = 1e-63
Identities = 205/689 (29%), Positives = 336/689 (48%), Gaps = 47/689 (6%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 139 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 197
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 198 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 257
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 258 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 317
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 318 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 377
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 378 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 429
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 488
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G +++++ A+DADSG N ++ Y L E
Sbjct: 489 KDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE---- 544
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 545 FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 603
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
YK V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 660
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYS---DTIP 3033
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y+ + +
Sbjct: 661 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL 718
Query: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQAV 3092
PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D + +
Sbjct: 719 PSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGL 778
Query: 3093 YHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
+ +LV+A D G S+V+ VN++
Sbjct: 779 HRVLVKANDLGQPDSLFSVVIVNLFVNES 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 318/678 (46%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 210 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 267
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 268 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 383
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 384 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 440
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + + LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 500
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V ATD D GPNAEI+Y + + +F ++ +TG
Sbjct: 501 SFVTVSIPENNSPGIQ-------LMKVSATDADSGPNAEINYLL-GPDAPPEFSLDRRTG 552
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 553 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYKF 609
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 610 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 669
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTS----KYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F YE+V+P T P T +
Sbjct: 670 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVF 728
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 729 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 785
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 786 NDLGQP-DSLFSVVIVNL 802
Score = 214 bits (545), Expect = 2e-54
Identities = 215/707 (30%), Positives = 324/707 (45%), Gaps = 55/707 (7%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 108 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 167
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 168 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 227
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 228 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKE 463
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G + V A
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSAT 523
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS ++ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 524 DADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY+ + EN P H V + TD D G VT I+
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 642
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 643 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 696
Query: 2587 TDDNDNAPQFRATKYEVN---IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVK 2643
D NDN P F Y + + S GT V +V+A D D G NA++ Y+I + +
Sbjct: 697 -DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NTR 753
Query: 2644 ENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
+ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 754 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 800
Score = 196 bits (498), Expect = 4e-49
Identities = 209/763 (27%), Positives = 330/763 (43%), Gaps = 75/763 (9%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 104 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 160
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 221 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 279 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 390
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P +++++SA D D ++ Y L P +F LD TG L +KLD E
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPP----EFSLDRRTGMLTVVKKLDREKED 566
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + YK V E+ V +T
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 627 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 684
Query: 1647 MSEITSVRIFVTIADNASPKF--TSKEYSVEL-SETVSIGSFVGMVTA-----HSQSSVV 1698
S V I V ++ P F YS EL + + G+ V V A + V
Sbjct: 685 RSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 744
Query: 1699 YEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS------------ 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 745 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 1747 ----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILV 847
Score = 191 bits (485), Expect = 1e-47
Identities = 171/654 (26%), Positives = 291/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 200 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 371
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 372 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G +++V ATD+DS PN I+Y + + +
Sbjct: 485 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---A 541
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 542 PPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 601
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y+ + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 602 FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 659
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 660 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 720 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 772
Score = 176 bits (447), Expect = 4e-43
Identities = 155/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 359 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 410
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 411 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLENAAYLDYESTK-E 463
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P ++ V A
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLMKVSA 522
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 523 TDADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 581
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT YK EN+P TV ++ DPD G+N VT SI
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 642 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 698
Query: 563 NDNTPLF----EKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F + E +P G + V A+D D V+Y I GN D F+
Sbjct: 699 NDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 757
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 758 IDQETGNITL 767
Score = 172 bits (437), Expect = 5e-42
Identities = 185/712 (25%), Positives = 319/712 (44%), Gaps = 54/712 (7%)
Query: 1755 LQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEP 1814
++D NDNAP+F I E+++INS A D D N + Y +++
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPA-------AVDPDVGINGVQNYELIKS 213
Query: 1815 -SVHTYFAIDSSTGAIHTVL----SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHV 1869
++ I++ G L LD EE + V+V D G P+ + A + V V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSS--TAILQVSV 271
Query: 1870 IDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE--GNIGEK- 1926
D ND PVF + E S+ G V ++ATDAD +++ +S + NI +
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 1927 FSMDYKTGALTVQNTTQLRS--RYELTVRASDGRFAGLTS-VKINVKESKES----HLKF 1979
F ++ TG +T++ ++L V ASDG + V +NV + ++ +++
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 1980 TQDVYS--AVVKENSTEAETLAVITAIGNPINE----PLFYHILNPDRRFKISRTSGVLS 2033
+ + V+ EN +A+IT + F P R + +L
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 451
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
D E + + + + + KP ++ + V+D+NDNAPVF + +
Sbjct: 452 NAAY-LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYL-KEHHEHFQIGP-LGEISLKKQFELDTLNKEYL 2151
G + V+A D DSG N E++Y L + F + G +++ K+ + + +K YL
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDK-YL 569
Query: 2152 VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP 2209
T++AKD G P ++ V V ++++ N PVF Y + E++ H V + P
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 2210 E-GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS---LTGAHA 2265
+ G +++ D FTI+ TGVI D E +Y ++A D + A
Sbjct: 630 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 2266 EVFVDIIVDDINDNPPVFA----QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQ 2321
+V ++++ D+NDN PVF SY + L + GT V QV A D+D+ N + Y
Sbjct: 690 KVTINVV--DVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 746
Query: 2322 MFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP-TLSSDVIVTVDV 2380
+ G +++ D F +D TG I+L+ D H + V+A D G P +L S VIV + V
Sbjct: 747 IVGGNTR--DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432
+ N L + + ++ + P+ T + + +SD K+ + ++G
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPN----TEIADVSSPTSDYVKILVAAVAG 852
Score = 161 bits (407), Expect = 2e-38
Identities = 187/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 391
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP-HSGTIITQ 1722
+++TV + + + T + +V + D N F + P S + +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 451
Query: 1723 KA--LDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
A LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S ++ + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 512 SPGIQLMK-------VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y+ + LP +
Sbjct: 564 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 619
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 620 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 675
Query: 1953 RASDGRFAGLTS---VKINVKESKESHLKFTQDVYS---AVVKENSTEAETLAVITAIGN 2006
+A DG +S V INV + ++ F Y+ +V ++ + + A+ N
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 794
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 795 FSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADV 835
Score = 128 bits (322), Expect = 1e-28
Identities = 164/705 (23%), Positives = 275/705 (39%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 156 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 216 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 270
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 331 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 384
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G +M +SA D D G N + Y + F++D TG ++ + LD E
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREK 564
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F + +P +L +
Sbjct: 565 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 622
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 623 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 679
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ V + K + +N +S
Sbjct: 680 GGRVSRSSSAKVTI--------------NVVDVNDNKPVFIVPPYN-----------YSY 714
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
+P ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 715 ELVLP---STNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 760
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 761 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 801
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 288 bits (738), Expect = 7e-77
Identities = 229/723 (31%), Positives = 349/723 (48%), Gaps = 42/723 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 99 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 154
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 155 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 213
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 214 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 272
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 273 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 332
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 333 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 392
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+ + LD
Sbjct: 393 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLD 446
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 447 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 506
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
+V ATDAD+G N +I Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 507 MKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN 566
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 567 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 625
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 626 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 683
Query: 3325 VTDINDNTPVFSQDTYTTVISEDAVLEQS-----VITVMADDADGPSNSHIHYSIIDGNQ 3379
V D+NDN PVF Y S + VL + V V+A D D N+ + YSI+ GN
Sbjct: 684 VVDVNDNKPVFIVPPYN--YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 741
Query: 3380 GSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAP 3438
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA
Sbjct: 742 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNAT 801
Query: 3439 VFS 3441
+ +
Sbjct: 802 LIN 804
Score = 256 bits (653), Expect = 5e-67
Identities = 225/814 (27%), Positives = 358/814 (43%), Gaps = 91/814 (11%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 146 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 204
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 205 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 264
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 265 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 324
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 325 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 380
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRI 985
P N V + E++P T I + D D +G+V DH E F + + +
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 438
Query: 986 VQQ---LDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
++ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 439 LENAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 495
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G +M VSA D D+ + EI Y + F + TG++ +LDRE
Sbjct: 496 IPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE 554
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 555 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLIT 614
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 615 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 671
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 672 VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP--------GTVVFQVIAVD 723
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRPQK 1335
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 724 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQPD- 781
Query: 1336 SSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG 1395
SL + F +V + + ++ S+E P P
Sbjct: 782 ----------------SLFSVVIVNLFVNESVTNATLINELVRK-SIEAPVTP------- 817
Query: 1396 GNYDSHFDVDKGTGTIIVAKPLDAEQKSNY-NLTVEATDGTTTILTQVFIKVIDTNDHRP 1454
T V+ P S+Y + V A GT T++ +FI + P
Sbjct: 818 -----------NTEIADVSSP-----TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAP 861
Query: 1455 QFSTSKYEVVIPEDTAPETEILQISAVDQDEKNK 1488
++ + E P E Q+ + + +K K
Sbjct: 862 HLKAAQKNMQNSEWATPNPENRQMIMMKKKKKKK 895
Score = 248 bits (634), Expect = 8e-65
Identities = 192/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 202
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 262
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 263 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 322
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 323 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 379
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 380 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 436
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++EN LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 437 FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 496
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ ++ V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 497 PENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKED 555
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y + EN P +V + V
Sbjct: 556 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 615
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 616 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 672
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP E+ + S+ G V+ ++ A D D +
Sbjct: 673 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTGMN 729
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 730 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 762
Score = 244 bits (624), Expect = 1e-63
Identities = 205/689 (29%), Positives = 336/689 (48%), Gaps = 47/689 (6%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 128 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 186
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 187 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 246
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 247 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 306
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 307 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 366
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 367 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 418
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 419 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 477
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G +++++ A+DADSG N ++ Y L E
Sbjct: 478 KDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE---- 533
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 534 FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 592
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
YK V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 593 HNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 649
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYS---DTIP 3033
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y+ + +
Sbjct: 650 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL 707
Query: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQAV 3092
PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D + +
Sbjct: 708 PSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGL 767
Query: 3093 YHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
+ +LV+A D G S+V+ VN++
Sbjct: 768 HRVLVKANDLGQPDSLFSVVIVNLFVNES 796
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 318/678 (46%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 139 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 198
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 199 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 256
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 257 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 314
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 315 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 372
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 373 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 429
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + + LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 430 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 489
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V ATD D GPNAEI+Y + + +F ++ +TG
Sbjct: 490 SFVTVSIPENNSPGIQ-------LMKVSATDADSGPNAEINYLL-GPDAPPEFSLDRRTG 541
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 542 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYKF 598
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 599 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 658
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTS----KYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F YE+V+P T P T +
Sbjct: 659 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-STNPGTVVF 717
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 718 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 774
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 775 NDLGQP-DSLFSVVIVNL 791
Score = 214 bits (545), Expect = 2e-54
Identities = 215/707 (30%), Positives = 324/707 (45%), Gaps = 55/707 (7%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 97 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 156
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 157 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 216
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 217 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 276
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 277 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 336
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 337 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 394
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 395 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKE 452
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G + V A
Sbjct: 453 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSAT 512
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS ++ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 513 DADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 571
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY+ + EN P H V + TD D G VT I+
Sbjct: 572 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 631
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 632 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 685
Query: 2587 TDDNDNAPQFRATKYEVN---IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVK 2643
D NDN P F Y + + S GT V +V+A D D G NA++ Y+I + +
Sbjct: 686 -DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NTR 742
Query: 2644 ENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
+ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 743 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 789
Score = 196 bits (498), Expect = 4e-49
Identities = 209/763 (27%), Positives = 330/763 (43%), Gaps = 75/763 (9%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 93 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 149
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 210 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 267
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 268 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 320
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 321 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 379
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 380 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 439
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 440 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P +++++SA D D ++ Y L P +F LD TG L +KLD E
Sbjct: 500 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPP----EFSLDRRTGMLTVVKKLDREKED 555
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + YK V E+ V +T
Sbjct: 556 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 615
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 616 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 673
Query: 1647 MSEITSVRIFVTIADNASPKF--TSKEYSVEL-SETVSIGSFVGMVTA-----HSQSSVV 1698
S V I V ++ P F YS EL + + G+ V V A + V
Sbjct: 674 RSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 733
Query: 1699 YEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS------------ 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 734 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 793
Query: 1747 ----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 794 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILV 836
Score = 191 bits (485), Expect = 1e-47
Identities = 171/654 (26%), Positives = 291/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 129 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 188
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 189 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 241
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 242 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 301
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 302 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 360
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 361 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 414 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 473
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G +++V ATD+DS PN I+Y + + +
Sbjct: 474 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---A 530
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 531 PPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 590
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y+ + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 591 FTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 648
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 649 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 708
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 709 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 761
Score = 176 bits (447), Expect = 4e-43
Identities = 155/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 228 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 287
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 288 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 347
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 348 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 399
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 400 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLENAAYLDYESTK-E 452
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P ++ V A
Sbjct: 453 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLMKVSA 511
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 512 TDADSGPNAEINYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 570
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT YK EN+P TV ++ DPD G+N VT SI
Sbjct: 571 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 631 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 687
Query: 563 NDNTPLF----EKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F + E +P G + V A+D D V+Y I GN D F+
Sbjct: 688 NDNKPVFIVPPYNYSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 746
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 747 IDQETGNITL 756
Score = 172 bits (437), Expect = 5e-42
Identities = 185/712 (25%), Positives = 319/712 (44%), Gaps = 54/712 (7%)
Query: 1755 LQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEP 1814
++D NDNAP+F I E+++INS A D D N + Y +++
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPA-------AVDPDVGINGVQNYELIKS 202
Query: 1815 -SVHTYFAIDSSTGAIHTVL----SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHV 1869
++ I++ G L LD EE + V+V D G P+ + A + V V
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSS--TAILQVSV 260
Query: 1870 IDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE--GNIGEK- 1926
D ND PVF + E S+ G V ++ATDAD +++ +S + NI +
Sbjct: 261 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 320
Query: 1927 FSMDYKTGALTVQNTTQLRS--RYELTVRASDGRFAGLTS-VKINVKESKES----HLKF 1979
F ++ TG +T++ ++L V ASDG + V +NV + ++ +++
Sbjct: 321 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 380
Query: 1980 TQDVYS--AVVKENSTEAETLAVITAIGNPINE----PLFYHILNPDRRFKISRTSGVLS 2033
+ + V+ EN +A+IT + F P R + +L
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 440
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
D E + + + + + KP ++ + V+D+NDNAPVF + +
Sbjct: 441 NAAY-LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYL-KEHHEHFQIGP-LGEISLKKQFELDTLNKEYL 2151
G + V+A D DSG N E++Y L + F + G +++ K+ + + +K YL
Sbjct: 500 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDK-YL 558
Query: 2152 VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP 2209
T++AKD G P ++ V V ++++ N PVF Y + E++ H V + P
Sbjct: 559 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 618
Query: 2210 E-GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS---LTGAHA 2265
+ G +++ D FTI+ TGVI D E +Y ++A D + A
Sbjct: 619 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 678
Query: 2266 EVFVDIIVDDINDNPPVFA----QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQ 2321
+V ++++ D+NDN PVF SY + L + GT V QV A D+D+ N + Y
Sbjct: 679 KVTINVV--DVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYS 735
Query: 2322 MFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP-TLSSDVIVTVDV 2380
+ G +++ D F +D TG I+L+ D H + V+A D G P +L S VIV + V
Sbjct: 736 IVGGNTR--DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 793
Query: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432
+ N L + + ++ + P+ T + + +SD K+ + ++G
Sbjct: 794 NESVTNATLINELVRKSIEAPVTPN----TEIADVSSPTSDYVKILVAAVAG 841
Score = 161 bits (407), Expect = 2e-38
Identities = 187/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 202
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 262
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 263 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 322
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 323 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 380
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP-HSGTIITQ 1722
+++TV + + + T + +V + D N F + P S + +
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 440
Query: 1723 KA--LDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
A LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 441 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 500
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S ++ + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 501 SPGIQLMK-------VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y+ + LP +
Sbjct: 553 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHG 608
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 609 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 664
Query: 1953 RASDGRFAGLTS---VKINVKESKESHLKFTQDVYS---AVVKENSTEAETLAVITAIGN 2006
+A DG +S V INV + ++ F Y+ +V ++ + + A+ N
Sbjct: 665 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 724
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 725 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 783
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 784 FSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADV 824
Score = 128 bits (322), Expect = 1e-28
Identities = 164/705 (23%), Positives = 275/705 (39%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 145 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 204
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 205 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 259
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 260 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 320 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 373
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 433
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 434 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 493
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G +M +SA D D G N + Y + F++D TG ++ + LD E
Sbjct: 494 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREK 553
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F + +P +L +
Sbjct: 554 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 611
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 612 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 668
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ V + K + +N +S
Sbjct: 669 GGRVSRSSSAKVTI--------------NVVDVNDNKPVFIVPPYN-----------YSY 703
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
+P ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 704 ELVLP---STNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 749
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 750 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 790
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 288 bits (738), Expect = 7e-77
Identities = 230/722 (31%), Positives = 349/722 (48%), Gaps = 40/722 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 78 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 133
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 192
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 251
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 252 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 312 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+T+ LD
Sbjct: 372 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
T+V A DAD+G N KI Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 546 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSA 604
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 605 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 662
Query: 3325 VTDINDNTPVF----SQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG 3380
V D+NDN PVF S +Y V+ V V+A D D N+ + YSI+ GN
Sbjct: 663 VVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 3381 SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAPV 3439
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA +
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATL 781
Query: 3440 FS 3441
+
Sbjct: 782 IN 783
Score = 249 bits (635), Expect = 6e-65
Identities = 196/658 (29%), Positives = 307/658 (46%), Gaps = 49/658 (7%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 125 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG---A 982
P N V + E++P T I + D D +G+V DH E F + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 417
Query: 983 VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
+ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 474
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G + VSA D D+ + +I Y + F + TG++ +LDRE
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 650
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP--------GTVVFQVIAVD 702
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP 1333
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 703 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQP 759
Score = 245 bits (626), Expect = 6e-64
Identities = 191/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 358
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++E LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ + V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y+ + EN P +V + V
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 595 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP+ E+ + S+ G V+ ++ A D D +
Sbjct: 652 SRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTN---PGTVVFQVIAVDNDTGMN 708
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 709 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 239 bits (610), Expect = 5e-62
Identities = 205/690 (29%), Positives = 332/690 (48%), Gaps = 49/690 (7%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 107 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 165
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 166 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 225
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 226 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 285
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 286 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 346 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 397
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 398 CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 456
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G ++ ++ A DADSG N ++ Y L E
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE---- 512
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 571
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
Y V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 628
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVC----EKTLYSDTI 3032
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y +
Sbjct: 629 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQA 3091
P PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D +
Sbjct: 687 P-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Query: 3092 VYHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
++ +LV+A D G S+V+ VN++
Sbjct: 746 LHRVLVKANDLGQPDSLFSVVIVNLFVNES 775
Score = 235 bits (600), Expect = 7e-61
Identities = 209/706 (29%), Positives = 333/706 (47%), Gaps = 50/706 (7%)
Query: 2267 VFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
V + +++DINDN P+F +++ E S I + A D D N +Y++
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--- 179
Query: 2327 SKSHDHFHVD-------SSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
KS + F +D + + + LD E+ + + V+ DGG P SS I+ V
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYS---ILSGNDHK 2436
VTD NDN P+F++ E I E+AP G VT + A DAD + K+ +S ++S +
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF---RSSTQVHVTVIGGNLHSP--A 2491
F +++ TG+IT+ P + L + SDG R+ V+VT + N+ S
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2492 FLQNEYE--VELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA-KDRFYINERGQI 2548
++ N V L+EN PL+T + + TD D+ G VT ++ + R + + +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2549 FTLEKLDRETPAEKVISVRLMAKDAG----GKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604
T LD E+ E +++L+A DAG + A + V D+NDNAP F + V+
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2605 IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGL 2664
I + + G + KV A DAD G NA I Y + D+ ++ +G++T + L
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP---EFSLDCRTGMLTVVKKLDRE 531
Query: 2665 ENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDL 2724
+ + + F + A DNG P S V V+V I+ P F+ Y F V E++P + L
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 2725 IRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
I S V + + N D F ID Q+G ++ S D E + Y F + A
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKA---- 645
Query: 2785 DDHEMVA---SVDVSIQVKDANDNSPVFESSP----YEAFIVENLPGGSRVIQIRASDAD 2837
+D V+ S V+I V D NDN PVF P YE + PG + V Q+ A D D
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG-TVVFQVIAVDND 704
Query: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
+G N +V YS+ + ++ FAI+ ETG IT +++ D +++ V A+D G+
Sbjct: 705 TGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTT 2943
L S IV++ V + + + K T + P + + S T
Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPT 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 319/678 (47%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 178 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 235
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 236 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 351
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 408
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + T+ LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 468
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V A D D GPNA+I+Y + + +F ++ +TG
Sbjct: 469 SFVTVSIPENNSPGIQ-------LTKVSAMDADSGPNAKINYLL-GPDAPPEFSLDCRTG 520
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 521 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYNF 577
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 637
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQF----STSKYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F S YE+V+P T P T +
Sbjct: 638 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVF 696
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 697 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 753
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 754 NDLGQP-DSLFSVVIVNL 770
Score = 216 bits (551), Expect = 3e-55
Identities = 218/708 (30%), Positives = 325/708 (45%), Gaps = 57/708 (8%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 76 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKE 431
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G +T V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS K+ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 492 DADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY + EN P H V + TD D G VT I+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 611 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 664
Query: 2587 TDDNDNAPQF----RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
D NDN P F YE+ + S GT V +V+A D D G NA++ Y+I +
Sbjct: 665 -DVNDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NT 720
Query: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
++ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 721 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 768
Score = 209 bits (532), Expect = 5e-53
Identities = 188/646 (29%), Positives = 300/646 (46%), Gaps = 72/646 (11%)
Query: 422 ILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAYKAAFDENV 476
+ + + R++ + ++V D +++ST +L V V N N P F +T + + EN
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 477 PIGTTVMSLSAVDPDEGENGYVTYSIANL-NHVPFAIDHF---TGAVSTSENLDYELMPR 532
P+GT+V L A D D GEN + +S +NL +++ + H TG ++ E LD E P
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 533 VYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVS 592
+ L + ASD GL R + VL +T ++NDN P +
Sbjct: 323 -HKLLVLASDGGLMPARAM-VLVNVT--DVNDNVPSID---------------------- 356
Query: 593 AIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA-TDGE 651
++Y + N+ S N L+ K +L+ + K + H+ R+T TD E
Sbjct: 357 ---------IRYIVNPVNDTVVLSENIP---LNTKIALIT-VTDKDADHNGRVTCFTDHE 403
Query: 652 NFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLH---NQGEVEDIFFDSHS 708
P + + L + K A KLL A+ NQ + +F
Sbjct: 404 ---IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKD 458
Query: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
N + P F + T + + EN G + +++ D D+G N K+ Y + G + F +D
Sbjct: 459 ENDNAPVFTQSFVT-VSIPENNSPGIQLTKVSAMDADSGPNAKINYLL-GPDAPPEFSLD 516
Query: 769 METGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYF 828
TGML ++ LDRE DKY I D G+P + + V ++D NDN P F Y
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 829 VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888
V E+ H + + TD D G N VT SI+ + D F+IDS TGV+ DRE Q
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQ 636
Query: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE---GTV 945
++ ++A D R S+ V +++ DVNDN P FI P LP GTV
Sbjct: 637 ESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTV 694
Query: 946 IMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
+ + A D D G + +VRYS++ + F +D+ +G + ++++ D ++ + V+A
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAN 754
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENL-HPPVFSSFVEKGTVKEDAPV 1049
D G+P SL S V + VNE++ + + + V K T +APV
Sbjct: 755 DLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKST---EAPV 794
Score = 196 bits (497), Expect = 6e-49
Identities = 208/764 (27%), Positives = 330/764 (43%), Gaps = 77/764 (10%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 72 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 128
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 189 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 247 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 358
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P ++ ++SA+D D K+ Y L P +F LD TG L +KLD E
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP----EFSLDCRTGMLTVVKKLDREKED 534
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + Y V E+ V +T
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 595 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1647 MSEITSVRIFVTIADNASPKF----TSKEYSVELSETVSIGSFVGMVTA-----HSQSSV 1697
S V I V ++ P F ++ Y + L T + G+ V V A + V
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEV 711
Query: 1698 VYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS----------- 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 712 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLF 771
Query: 1747 -----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 772 VNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILV 815
Score = 189 bits (479), Expect = 7e-47
Identities = 170/654 (25%), Positives = 288/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 108 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 167
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 168 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 220
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 221 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 339
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 340 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 392
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 393 NGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 452
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G + +V A D+DS PN I+Y + + +
Sbjct: 453 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD---A 509
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 510 PPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 569
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 570 FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 627
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 628 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP 687
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 688 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 740
Score = 177 bits (448), Expect = 3e-43
Identities = 156/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 327 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 378
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 379 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLETAAYLDYESTK-E 431
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P + V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
+ A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 491 MDADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 549
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT Y EN+P TV ++ DPD G+N VT SI
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 610 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 666
Query: 563 NDNTPLF--EKINC--EGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F NC E +P G + V A+D D V+Y I GN D F+
Sbjct: 667 NDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 726 IDQETGNITL 735
Score = 159 bits (401), Expect = 8e-38
Identities = 186/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 359
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP---HSGTII 1720
+++TV + + + T + +V + D N F + P + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 419
Query: 1721 TQKALDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
T LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S + LT + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 480 S-PGIQLTK------VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y + LP +
Sbjct: 532 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 588 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1953 RASD-GRFAGLTSVK-----INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGN 2006
+A D GR + +S K ++V ++K + + +V ++ + + A+ N
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 762
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 763 FSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADV 803
Score = 127 bits (318), Expect = 3e-28
Identities = 160/705 (22%), Positives = 273/705 (38%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 238
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 299 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 352
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G + +SA+D D G N + Y + F++D TG ++ + LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREK 532
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F +P +L +
Sbjct: 533 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 647
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ + + + + +F S
Sbjct: 648 GGRVSRSSSAKVTI----------------------------NVVDVNDNKPVFIVPPSN 679
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
++ ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 680 CSYELVLPSTNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 728
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 729 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 769
Score = 122 bits (305), Expect = 1e-26
Identities = 163/670 (24%), Positives = 281/670 (41%), Gaps = 67/670 (10%)
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVV-----YE-IKD 1703
+ +R + ++ +P F + ++ + E +I S + A + YE IK
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1704 GNTGDAFDINPHSGT----IITQKALDFETLPIYTLIIQGTNMAGLSTNTTVL--VHLQD 1757
N I G +I QK LD E Y + ++ + ++T + V + D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY---HIVEP 1814
NDN PVF + E I E+A + + V + A DAD NA + + ++V
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSN 294
Query: 1815 SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDIND 1874
F ++++TG I LD EET V D G A V V+V D+ND
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVND 350
Query: 1875 CPP-----VFAKPLYEASLL---LPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEK 1926
P P+ + +L +P + +ITV DAD + + T+ I +
Sbjct: 351 NVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG---RVTCFTDHEIPFR 407
Query: 1927 ----FSMDY--KTGALTVQNTTQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHL 1977
FS + +T A +T+ Y + + A+D L + I VK+ ++
Sbjct: 408 LRPVFSNQFLLETAAYLDYESTK---EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAP 464
Query: 1978 KFTQDVYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILNPDR--RFKISRTSGVLS 2033
FTQ + + EN++ L ++A+ + N + Y +L PD F + +G+L
Sbjct: 465 VFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGML- 522
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T DRE+++ + + + P ++V V V + DQNDN+PVF + Y V +
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI-GPLGEISLKKQFELDTLNKEYLV 2152
+ +T D D G N V + + ++ F I G I F+ + + Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK-QESYTF 641
Query: 2153 TVVAKDGG--NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP------VVHV 2204
V A+DGG + + SA+V + + +N PVF P + + +P V+ V
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Query: 2205 QANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH 2264
++ +V YSI G+ F I+ TG I ++ D +++ ++A D G
Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQP 759
Query: 2265 AEVFVDIIVD 2274
+F +IV+
Sbjct: 760 DSLFSVVIVN 769
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 288 bits (738), Expect = 7e-77
Identities = 230/722 (31%), Positives = 349/722 (48%), Gaps = 40/722 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 78 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 133
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 192
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 251
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 252 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 312 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+T+ LD
Sbjct: 372 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
T+V A DAD+G N KI Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 546 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSA 604
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 605 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 662
Query: 3325 VTDINDNTPVF----SQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG 3380
V D+NDN PVF S +Y V+ V V+A D D N+ + YSI+ GN
Sbjct: 663 VVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 3381 SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAPV 3439
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA +
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATL 781
Query: 3440 FS 3441
+
Sbjct: 782 IN 783
Score = 249 bits (635), Expect = 6e-65
Identities = 196/658 (29%), Positives = 307/658 (46%), Gaps = 49/658 (7%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 125 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG---A 982
P N V + E++P T I + D D +G+V DH E F + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 417
Query: 983 VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
+ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 474
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G + VSA D D+ + +I Y + F + TG++ +LDRE
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 650
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP--------GTVVFQVIAVD 702
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP 1333
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 703 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQP 759
Score = 245 bits (626), Expect = 6e-64
Identities = 191/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 358
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++E LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ + V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y+ + EN P +V + V
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 595 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP+ E+ + S+ G V+ ++ A D D +
Sbjct: 652 SRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTN---PGTVVFQVIAVDNDTGMN 708
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 709 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 239 bits (610), Expect = 5e-62
Identities = 205/690 (29%), Positives = 332/690 (48%), Gaps = 49/690 (7%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 107 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 165
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 166 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 225
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 226 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 285
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 286 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 346 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 397
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 398 CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 456
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G ++ ++ A DADSG N ++ Y L E
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE---- 512
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 571
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
Y V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 628
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVC----EKTLYSDTI 3032
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y +
Sbjct: 629 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQA 3091
P PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D +
Sbjct: 687 P-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Query: 3092 VYHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
++ +LV+A D G S+V+ VN++
Sbjct: 746 LHRVLVKANDLGQPDSLFSVVIVNLFVNES 775
Score = 235 bits (600), Expect = 7e-61
Identities = 209/706 (29%), Positives = 333/706 (47%), Gaps = 50/706 (7%)
Query: 2267 VFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
V + +++DINDN P+F +++ E S I + A D D N +Y++
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--- 179
Query: 2327 SKSHDHFHVD-------SSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
KS + F +D + + + LD E+ + + V+ DGG P SS I+ V
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYS---ILSGNDHK 2436
VTD NDN P+F++ E I E+AP G VT + A DAD + K+ +S ++S +
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF---RSSTQVHVTVIGGNLHSP--A 2491
F +++ TG+IT+ P + L + SDG R+ V+VT + N+ S
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2492 FLQNEYE--VELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA-KDRFYINERGQI 2548
++ N V L+EN PL+T + + TD D+ G VT ++ + R + + +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2549 FTLEKLDRETPAEKVISVRLMAKDAG----GKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604
T LD E+ E +++L+A DAG + A + V D+NDNAP F + V+
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2605 IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGL 2664
I + + G + KV A DAD G NA I Y + D+ ++ +G++T + L
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP---EFSLDCRTGMLTVVKKLDRE 531
Query: 2665 ENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDL 2724
+ + + F + A DNG P S V V+V I+ P F+ Y F V E++P + L
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 2725 IRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
I S V + + N D F ID Q+G ++ S D E + Y F + A
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKA---- 645
Query: 2785 DDHEMVA---SVDVSIQVKDANDNSPVFESSP----YEAFIVENLPGGSRVIQIRASDAD 2837
+D V+ S V+I V D NDN PVF P YE + PG + V Q+ A D D
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG-TVVFQVIAVDND 704
Query: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
+G N +V YS+ + ++ FAI+ ETG IT +++ D +++ V A+D G+
Sbjct: 705 TGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTT 2943
L S IV++ V + + + K T + P + + S T
Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPT 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 319/678 (47%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 178 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 235
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 236 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 351
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 408
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + T+ LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 468
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V A D D GPNA+I+Y + + +F ++ +TG
Sbjct: 469 SFVTVSIPENNSPGIQ-------LTKVSAMDADSGPNAKINYLL-GPDAPPEFSLDCRTG 520
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 521 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYNF 577
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 637
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQF----STSKYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F S YE+V+P T P T +
Sbjct: 638 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVF 696
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 697 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 753
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 754 NDLGQP-DSLFSVVIVNL 770
Score = 216 bits (551), Expect = 3e-55
Identities = 218/708 (30%), Positives = 325/708 (45%), Gaps = 57/708 (8%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 76 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKE 431
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G +T V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS K+ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 492 DADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY + EN P H V + TD D G VT I+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 611 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 664
Query: 2587 TDDNDNAPQF----RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
D NDN P F YE+ + S GT V +V+A D D G NA++ Y+I +
Sbjct: 665 -DVNDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NT 720
Query: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
++ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 721 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 768
Score = 209 bits (532), Expect = 5e-53
Identities = 188/646 (29%), Positives = 300/646 (46%), Gaps = 72/646 (11%)
Query: 422 ILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAYKAAFDENV 476
+ + + R++ + ++V D +++ST +L V V N N P F +T + + EN
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 477 PIGTTVMSLSAVDPDEGENGYVTYSIANL-NHVPFAIDHF---TGAVSTSENLDYELMPR 532
P+GT+V L A D D GEN + +S +NL +++ + H TG ++ E LD E P
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 533 VYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVS 592
+ L + ASD GL R + VL +T ++NDN P +
Sbjct: 323 -HKLLVLASDGGLMPARAM-VLVNVT--DVNDNVPSID---------------------- 356
Query: 593 AIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA-TDGE 651
++Y + N+ S N L+ K +L+ + K + H+ R+T TD E
Sbjct: 357 ---------IRYIVNPVNDTVVLSENIP---LNTKIALIT-VTDKDADHNGRVTCFTDHE 403
Query: 652 NFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLH---NQGEVEDIFFDSHS 708
P + + L + K A KLL A+ NQ + +F
Sbjct: 404 ---IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKD 458
Query: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
N + P F + T + + EN G + +++ D D+G N K+ Y + G + F +D
Sbjct: 459 ENDNAPVFTQSFVT-VSIPENNSPGIQLTKVSAMDADSGPNAKINYLL-GPDAPPEFSLD 516
Query: 769 METGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYF 828
TGML ++ LDRE DKY I D G+P + + V ++D NDN P F Y
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 829 VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888
V E+ H + + TD D G N VT SI+ + D F+IDS TGV+ DRE Q
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQ 636
Query: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE---GTV 945
++ ++A D R S+ V +++ DVNDN P FI P LP GTV
Sbjct: 637 ESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTV 694
Query: 946 IMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
+ + A D D G + +VRYS++ + F +D+ +G + ++++ D ++ + V+A
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAN 754
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENL-HPPVFSSFVEKGTVKEDAPV 1049
D G+P SL S V + VNE++ + + + V K T +APV
Sbjct: 755 DLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKST---EAPV 794
Score = 196 bits (497), Expect = 6e-49
Identities = 208/764 (27%), Positives = 330/764 (43%), Gaps = 77/764 (10%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 72 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 128
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 189 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 247 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 358
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P ++ ++SA+D D K+ Y L P +F LD TG L +KLD E
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP----EFSLDCRTGMLTVVKKLDREKED 534
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + Y V E+ V +T
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 595 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1647 MSEITSVRIFVTIADNASPKF----TSKEYSVELSETVSIGSFVGMVTA-----HSQSSV 1697
S V I V ++ P F ++ Y + L T + G+ V V A + V
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEV 711
Query: 1698 VYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS----------- 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 712 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLF 771
Query: 1747 -----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 772 VNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILV 815
Score = 189 bits (479), Expect = 7e-47
Identities = 170/654 (25%), Positives = 288/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 108 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 167
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 168 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 220
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 221 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 339
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 340 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 392
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 393 NGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 452
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G + +V A D+DS PN I+Y + + +
Sbjct: 453 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD---A 509
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 510 PPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 569
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 570 FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 627
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 628 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP 687
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 688 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 740
Score = 177 bits (448), Expect = 3e-43
Identities = 156/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 327 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 378
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 379 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLETAAYLDYESTK-E 431
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P + V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
+ A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 491 MDADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 549
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT Y EN+P TV ++ DPD G+N VT SI
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 610 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 666
Query: 563 NDNTPLF--EKINC--EGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F NC E +P G + V A+D D V+Y I GN D F+
Sbjct: 667 NDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 726 IDQETGNITL 735
Score = 159 bits (401), Expect = 8e-38
Identities = 186/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 359
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP---HSGTII 1720
+++TV + + + T + +V + D N F + P + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 419
Query: 1721 TQKALDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
T LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S + LT + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 480 S-PGIQLTK------VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y + LP +
Sbjct: 532 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 588 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1953 RASD-GRFAGLTSVK-----INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGN 2006
+A D GR + +S K ++V ++K + + +V ++ + + A+ N
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 762
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 763 FSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADV 803
Score = 127 bits (318), Expect = 3e-28
Identities = 160/705 (22%), Positives = 273/705 (38%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 238
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 299 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 352
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G + +SA+D D G N + Y + F++D TG ++ + LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREK 532
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F +P +L +
Sbjct: 533 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 647
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ + + + + +F S
Sbjct: 648 GGRVSRSSSAKVTI----------------------------NVVDVNDNKPVFIVPPSN 679
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
++ ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 680 CSYELVLPSTNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 728
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 729 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 769
Score = 122 bits (305), Expect = 1e-26
Identities = 163/670 (24%), Positives = 281/670 (41%), Gaps = 67/670 (10%)
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVV-----YE-IKD 1703
+ +R + ++ +P F + ++ + E +I S + A + YE IK
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1704 GNTGDAFDINPHSGT----IITQKALDFETLPIYTLIIQGTNMAGLSTNTTVL--VHLQD 1757
N I G +I QK LD E Y + ++ + ++T + V + D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY---HIVEP 1814
NDN PVF + E I E+A + + V + A DAD NA + + ++V
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSN 294
Query: 1815 SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDIND 1874
F ++++TG I LD EET V D G A V V+V D+ND
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVND 350
Query: 1875 CPP-----VFAKPLYEASLL---LPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEK 1926
P P+ + +L +P + +ITV DAD + + T+ I +
Sbjct: 351 NVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG---RVTCFTDHEIPFR 407
Query: 1927 ----FSMDY--KTGALTVQNTTQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHL 1977
FS + +T A +T+ Y + + A+D L + I VK+ ++
Sbjct: 408 LRPVFSNQFLLETAAYLDYESTK---EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAP 464
Query: 1978 KFTQDVYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILNPDR--RFKISRTSGVLS 2033
FTQ + + EN++ L ++A+ + N + Y +L PD F + +G+L
Sbjct: 465 VFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGML- 522
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T DRE+++ + + + P ++V V V + DQNDN+PVF + Y V +
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI-GPLGEISLKKQFELDTLNKEYLV 2152
+ +T D D G N V + + ++ F I G I F+ + + Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK-QESYTF 641
Query: 2153 TVVAKDGG--NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP------VVHV 2204
V A+DGG + + SA+V + + +N PVF P + + +P V+ V
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Query: 2205 QANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH 2264
++ +V YSI G+ F I+ TG I ++ D +++ ++A D G
Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQP 759
Query: 2265 AEVFVDIIVD 2274
+F +IV+
Sbjct: 760 DSLFSVVIVN 769
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 288 bits (738), Expect = 7e-77
Identities = 230/722 (31%), Positives = 349/722 (48%), Gaps = 40/722 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 78 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 133
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 192
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 251
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 252 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 312 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+T+ LD
Sbjct: 372 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
T+V A DAD+G N KI Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 546 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSA 604
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 605 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 662
Query: 3325 VTDINDNTPVF----SQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG 3380
V D+NDN PVF S +Y V+ V V+A D D N+ + YSI+ GN
Sbjct: 663 VVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 3381 SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAPV 3439
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA +
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATL 781
Query: 3440 FS 3441
+
Sbjct: 782 IN 783
Score = 249 bits (635), Expect = 6e-65
Identities = 196/658 (29%), Positives = 307/658 (46%), Gaps = 49/658 (7%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 125 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG---A 982
P N V + E++P T I + D D +G+V DH E F + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 417
Query: 983 VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
+ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 474
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G + VSA D D+ + +I Y + F + TG++ +LDRE
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 650
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP--------GTVVFQVIAVD 702
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP 1333
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 703 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQP 759
Score = 245 bits (626), Expect = 6e-64
Identities = 191/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 358
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++E LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ + V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y+ + EN P +V + V
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 595 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP+ E+ + S+ G V+ ++ A D D +
Sbjct: 652 SRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTN---PGTVVFQVIAVDNDTGMN 708
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 709 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 239 bits (610), Expect = 5e-62
Identities = 205/690 (29%), Positives = 332/690 (48%), Gaps = 49/690 (7%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 107 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 165
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 166 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 225
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 226 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 285
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 286 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 346 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 397
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 398 CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 456
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G ++ ++ A DADSG N ++ Y L E
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE---- 512
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 571
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
Y V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 628
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVC----EKTLYSDTI 3032
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y +
Sbjct: 629 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQA 3091
P PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D +
Sbjct: 687 P-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Query: 3092 VYHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
++ +LV+A D G S+V+ VN++
Sbjct: 746 LHRVLVKANDLGQPDSLFSVVIVNLFVNES 775
Score = 235 bits (600), Expect = 7e-61
Identities = 209/706 (29%), Positives = 333/706 (47%), Gaps = 50/706 (7%)
Query: 2267 VFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
V + +++DINDN P+F +++ E S I + A D D N +Y++
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--- 179
Query: 2327 SKSHDHFHVD-------SSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
KS + F +D + + + LD E+ + + V+ DGG P SS I+ V
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYS---ILSGNDHK 2436
VTD NDN P+F++ E I E+AP G VT + A DAD + K+ +S ++S +
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF---RSSTQVHVTVIGGNLHSP--A 2491
F +++ TG+IT+ P + L + SDG R+ V+VT + N+ S
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2492 FLQNEYE--VELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA-KDRFYINERGQI 2548
++ N V L+EN PL+T + + TD D+ G VT ++ + R + + +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2549 FTLEKLDRETPAEKVISVRLMAKDAG----GKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604
T LD E+ E +++L+A DAG + A + V D+NDNAP F + V+
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2605 IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGL 2664
I + + G + KV A DAD G NA I Y + D+ ++ +G++T + L
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP---EFSLDCRTGMLTVVKKLDRE 531
Query: 2665 ENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDL 2724
+ + + F + A DNG P S V V+V I+ P F+ Y F V E++P + L
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 2725 IRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
I S V + + N D F ID Q+G ++ S D E + Y F + A
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKA---- 645
Query: 2785 DDHEMVA---SVDVSIQVKDANDNSPVFESSP----YEAFIVENLPGGSRVIQIRASDAD 2837
+D V+ S V+I V D NDN PVF P YE + PG + V Q+ A D D
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG-TVVFQVIAVDND 704
Query: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
+G N +V YS+ + ++ FAI+ ETG IT +++ D +++ V A+D G+
Sbjct: 705 TGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTT 2943
L S IV++ V + + + K T + P + + S T
Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPT 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 319/678 (47%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 178 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 235
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 236 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 351
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 408
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + T+ LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 468
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V A D D GPNA+I+Y + + +F ++ +TG
Sbjct: 469 SFVTVSIPENNSPGIQ-------LTKVSAMDADSGPNAKINYLL-GPDAPPEFSLDCRTG 520
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 521 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYNF 577
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 637
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQF----STSKYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F S YE+V+P T P T +
Sbjct: 638 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVF 696
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 697 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 753
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 754 NDLGQP-DSLFSVVIVNL 770
Score = 216 bits (551), Expect = 3e-55
Identities = 218/708 (30%), Positives = 325/708 (45%), Gaps = 57/708 (8%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 76 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKE 431
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G +T V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS K+ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 492 DADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY + EN P H V + TD D G VT I+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 611 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 664
Query: 2587 TDDNDNAPQF----RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
D NDN P F YE+ + S GT V +V+A D D G NA++ Y+I +
Sbjct: 665 -DVNDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NT 720
Query: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
++ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 721 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 768
Score = 209 bits (532), Expect = 5e-53
Identities = 188/646 (29%), Positives = 300/646 (46%), Gaps = 72/646 (11%)
Query: 422 ILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAYKAAFDENV 476
+ + + R++ + ++V D +++ST +L V V N N P F +T + + EN
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 477 PIGTTVMSLSAVDPDEGENGYVTYSIANL-NHVPFAIDHF---TGAVSTSENLDYELMPR 532
P+GT+V L A D D GEN + +S +NL +++ + H TG ++ E LD E P
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 533 VYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVS 592
+ L + ASD GL R + VL +T ++NDN P +
Sbjct: 323 -HKLLVLASDGGLMPARAM-VLVNVT--DVNDNVPSID---------------------- 356
Query: 593 AIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA-TDGE 651
++Y + N+ S N L+ K +L+ + K + H+ R+T TD E
Sbjct: 357 ---------IRYIVNPVNDTVVLSENIP---LNTKIALIT-VTDKDADHNGRVTCFTDHE 403
Query: 652 NFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLH---NQGEVEDIFFDSHS 708
P + + L + K A KLL A+ NQ + +F
Sbjct: 404 ---IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKD 458
Query: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
N + P F + T + + EN G + +++ D D+G N K+ Y + G + F +D
Sbjct: 459 ENDNAPVFTQSFVT-VSIPENNSPGIQLTKVSAMDADSGPNAKINYLL-GPDAPPEFSLD 516
Query: 769 METGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYF 828
TGML ++ LDRE DKY I D G+P + + V ++D NDN P F Y
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 829 VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888
V E+ H + + TD D G N VT SI+ + D F+IDS TGV+ DRE Q
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQ 636
Query: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE---GTV 945
++ ++A D R S+ V +++ DVNDN P FI P LP GTV
Sbjct: 637 ESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTV 694
Query: 946 IMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
+ + A D D G + +VRYS++ + F +D+ +G + ++++ D ++ + V+A
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAN 754
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENL-HPPVFSSFVEKGTVKEDAPV 1049
D G+P SL S V + VNE++ + + + V K T +APV
Sbjct: 755 DLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKST---EAPV 794
Score = 196 bits (497), Expect = 6e-49
Identities = 208/764 (27%), Positives = 330/764 (43%), Gaps = 77/764 (10%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 72 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 128
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 189 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 247 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 358
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P ++ ++SA+D D K+ Y L P +F LD TG L +KLD E
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP----EFSLDCRTGMLTVVKKLDREKED 534
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + Y V E+ V +T
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 595 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1647 MSEITSVRIFVTIADNASPKF----TSKEYSVELSETVSIGSFVGMVTA-----HSQSSV 1697
S V I V ++ P F ++ Y + L T + G+ V V A + V
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEV 711
Query: 1698 VYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS----------- 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 712 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLF 771
Query: 1747 -----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 772 VNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILV 815
Score = 189 bits (479), Expect = 7e-47
Identities = 170/654 (25%), Positives = 288/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 108 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 167
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 168 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 220
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 221 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 339
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 340 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 392
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 393 NGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 452
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G + +V A D+DS PN I+Y + + +
Sbjct: 453 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD---A 509
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 510 PPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 569
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 570 FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 627
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 628 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP 687
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 688 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 740
Score = 177 bits (448), Expect = 3e-43
Identities = 156/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 327 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 378
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 379 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLETAAYLDYESTK-E 431
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P + V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
+ A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 491 MDADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 549
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT Y EN+P TV ++ DPD G+N VT SI
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 610 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 666
Query: 563 NDNTPLF--EKINC--EGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F NC E +P G + V A+D D V+Y I GN D F+
Sbjct: 667 NDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 726 IDQETGNITL 735
Score = 159 bits (401), Expect = 8e-38
Identities = 186/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 359
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP---HSGTII 1720
+++TV + + + T + +V + D N F + P + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 419
Query: 1721 TQKALDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
T LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S + LT + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 480 S-PGIQLTK------VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y + LP +
Sbjct: 532 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 588 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1953 RASD-GRFAGLTSVK-----INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGN 2006
+A D GR + +S K ++V ++K + + +V ++ + + A+ N
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 762
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 763 FSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADV 803
Score = 127 bits (318), Expect = 3e-28
Identities = 160/705 (22%), Positives = 273/705 (38%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 238
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 299 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 352
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G + +SA+D D G N + Y + F++D TG ++ + LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREK 532
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F +P +L +
Sbjct: 533 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 647
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ + + + + +F S
Sbjct: 648 GGRVSRSSSAKVTI----------------------------NVVDVNDNKPVFIVPPSN 679
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
++ ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 680 CSYELVLPSTNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 728
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 729 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 769
Score = 122 bits (305), Expect = 1e-26
Identities = 163/670 (24%), Positives = 281/670 (41%), Gaps = 67/670 (10%)
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVV-----YE-IKD 1703
+ +R + ++ +P F + ++ + E +I S + A + YE IK
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1704 GNTGDAFDINPHSGT----IITQKALDFETLPIYTLIIQGTNMAGLSTNTTVL--VHLQD 1757
N I G +I QK LD E Y + ++ + ++T + V + D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY---HIVEP 1814
NDN PVF + E I E+A + + V + A DAD NA + + ++V
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSN 294
Query: 1815 SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDIND 1874
F ++++TG I LD EET V D G A V V+V D+ND
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVND 350
Query: 1875 CPP-----VFAKPLYEASLL---LPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEK 1926
P P+ + +L +P + +ITV DAD + + T+ I +
Sbjct: 351 NVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG---RVTCFTDHEIPFR 407
Query: 1927 ----FSMDY--KTGALTVQNTTQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHL 1977
FS + +T A +T+ Y + + A+D L + I VK+ ++
Sbjct: 408 LRPVFSNQFLLETAAYLDYESTK---EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAP 464
Query: 1978 KFTQDVYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILNPDR--RFKISRTSGVLS 2033
FTQ + + EN++ L ++A+ + N + Y +L PD F + +G+L
Sbjct: 465 VFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGML- 522
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T DRE+++ + + + P ++V V V + DQNDN+PVF + Y V +
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI-GPLGEISLKKQFELDTLNKEYLV 2152
+ +T D D G N V + + ++ F I G I F+ + + Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK-QESYTF 641
Query: 2153 TVVAKDGG--NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP------VVHV 2204
V A+DGG + + SA+V + + +N PVF P + + +P V+ V
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Query: 2205 QANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH 2264
++ +V YSI G+ F I+ TG I ++ D +++ ++A D G
Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQP 759
Query: 2265 AEVFVDIIVD 2274
+F +IV+
Sbjct: 760 DSLFSVVIVN 769
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 288 bits (738), Expect = 7e-77
Identities = 230/722 (31%), Positives = 349/722 (48%), Gaps = 40/722 (5%)
Query: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAN 2803
E + E F + R KL + + +Y+ + E+ V + ++D N
Sbjct: 78 EEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----PDEIFRLVKIRFLIEDIN 133
Query: 2804 DNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---EVIESF 2860
DN+P+F ++ I EN S+ A D D G NG Y L +SQ++ +VIE+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET- 192
Query: 2861 AINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTA 2920
+ + KELD E++D Y +KV D G Q SSTAI+ V+VTD ND+ P F
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFKE 251
Query: 2921 EIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
+ ++ E+ P G + L TDAD E + F + + + +
Sbjct: 252 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 2981 KKPLDREKRDNYLLTITATDG-TFSSKAIVEVKVLDANDN----------SPVCEKTLYS 3029
K+PLDRE+ N+ L + A+DG ++A+V V V D NDN +PV + + S
Sbjct: 312 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 3030 DTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGE---LKTSTPLD 3086
+ IP + I I+ TD D N +T F+L P L+T+ LD
Sbjct: 372 ENIPLNTK----IALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLD 425
Query: 3087 REEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITVFENTEPGTLL 3144
E Y + + A D G S +L ++ D NDNAP F+ +++ EN PG L
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 3145 TRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ 3204
T+V A DAD+G N KI Y L A +FS++ +G++ + K LDRE + Y ++ A D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 3205 GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE 3264
G+P LT+ TV VS++D NDN PVF + EY V E++ V + D N+
Sbjct: 546 GVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSA 604
Query: 3265 ITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
+T SI+ +E+ F+IDS+TG + + D E Y V+A DGG S S A V +N
Sbjct: 605 VTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 662
Query: 3325 VTDINDNTPVF----SQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQG 3380
V D+NDN PVF S +Y V+ V V+A D D N+ + YSI+ GN
Sbjct: 663 VVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 3381 SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-NTTTVNIDVSDVNDNAPV 3439
F ID G + + + D + + + V+A+D G P + + VN+ V++ NA +
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATL 781
Query: 3440 FS 3441
+
Sbjct: 782 IN 783
Score = 249 bits (635), Expect = 6e-65
Identities = 196/658 (29%), Positives = 307/658 (46%), Gaps = 49/658 (7%)
Query: 702 IFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGN 760
I F +N + P F +T+ I + EN + S + D D G NG Y + N
Sbjct: 125 IRFLIEDINDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 761 EDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
+I+ G L + LDRE D Y + + V D G PQ+++ +L V V D N
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243
Query: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-----FSID 871
DN P F + V + E+ V + + Q+ ATD D+G N + +S F ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF---- 927
+ TG++ I PLDRE H L + A D + + +V V++ DVNDN P+
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 928 --IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG---A 982
P N V + E++P T I + D D +G+V DH E F + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVT-CFTDH-EIPFRLRPVFSNQFL 417
Query: 983 VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
+ LD+E + Y + + A D GKP L+ + + ++V D N+N PVF+ +
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAGKP-PLNQSAMLFIKVKDENDN--APVFTQSFVTVS 474
Query: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
+ E+ G + VSA D D+ + +I Y + F + TG++ +LDRE
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIE 1162
Y T+ A D GV PL+S + +++ + D NDN+P + Y + EN P+ +V I
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1163 AFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
DPD N + I N F+I +TG+I + DRE+Q+ + V D G
Sbjct: 594 VTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGGR 650
Query: 1223 PPKSTIARVIVKILDENDNKPQFL----QKFYKIRLPEREKPDRERNARREPLYHVIATD 1278
+S+ A+V + ++D NDNKP F+ Y++ LP ++ VIA D
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP--------GTVVFQVIAVD 702
Query: 1279 KDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP 1333
D G NAE+ YSI GN F I+ +TG ++ + G + +L +KA D G+P
Sbjct: 703 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-VKANDLGQP 759
Score = 245 bits (626), Expect = 6e-64
Identities = 191/633 (30%), Positives = 309/633 (48%), Gaps = 46/633 (7%)
Query: 3008 IVEVKVL--DANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS 3065
+V+++ L D NDN+P+ T+ + +IPE+ +A D D+ N Y L+ S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 3066 ----GAEKFKL--NPDTGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLED 3117
G + + +L LDREE+ Y + V+ DGG R A + +++ D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS----LIDSADGQFS 3173
NDN P F +++ EN GT +T++ ATDAD G N KI +S + + A F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYR 3233
+N +G+I +++PLDRE + L + A D GL + A V+V+V D+NDN P + R
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGL---MPARAMVLVNVTDVNDNVPSIDIR 358
Query: 3234 EY------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV 3287
+SE+I + T++ + +D + N +T + F +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 3288 FIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3344
F++E LDYES+ EY + + A D G P L+ A + + V D NDN PVF+Q T I
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 3345 SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETIS 3404
E+ + V A DAD N+ I+Y ++ + F++D G + V K LDRE
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 3405 GYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Y T+ A DNG PP + TV + + D NDN+PVF+ Y+ + EN P +V + V
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523
TD D N +I+ ND+ F ++ Q GV+ + + R++++ Y VK D G+
Sbjct: 595 TDPDYGDNS-AVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Query: 3524 QLSSLTYIDIRVIEES------IYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VY 3575
SS + I V++ + I PP+ E+ + S+ G V+ ++ A D D +
Sbjct: 652 SRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTN---PGTVVFQVIAVDNDTGMN 708
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI 3607
+ YS+ +LF++ G + +K D+
Sbjct: 709 AEVRYSIVGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 239 bits (610), Expect = 5e-62
Identities = 205/690 (29%), Positives = 332/690 (48%), Gaps = 49/690 (7%)
Query: 2460 FYSLNLSV-SDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTD 2518
FY + +++ D +FR ++ + N ++P F + + EN+ +++ D
Sbjct: 107 FYEVEVAILPDEIFRL-VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVD 165
Query: 2519 GDSGIYGHVTYHIV---NDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKD 2572
D GI G Y ++ N F D E Q+ ++LDRE V+ V++
Sbjct: 166 PDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGG 225
Query: 2573 AGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632
+ + + V +TD NDN P F+ T+ EV+I +A GTSV ++ A+DAD G NA I
Sbjct: 226 FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIH 285
Query: 2633 YAIEADSESVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYV 2691
++ ++ L +N +G+IT KE L E V A D G ++VLV V
Sbjct: 286 FSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 2692 KIL---PPEMQLPKFSEPFY-TFTVSEDVPIGTEIDLIR-----AEHSGTVLYSLVKGNT 2742
+ P + + P T +SE++P+ T+I LI A+H+G V T
Sbjct: 346 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--------T 397
Query: 2743 PESNRDESFVIDRQ-SGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASVDVSIQV 2799
++ + F + S + LE + LD+E+TK Y +LA + S + I+V
Sbjct: 398 CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLA-ADAGKPPLNQSAMLFIKV 456
Query: 2800 KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2859
KD NDN+PVF S I EN G ++ ++ A DADSG N ++ Y L E
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE---- 512
Query: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
F+++ TG +T +K+LD EK D Y ++A D+G L+S V V++ D ND+ P FT
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFT 571
Query: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979
Y V E+ P+ G + +++ TD D + N VT I D F +++ +
Sbjct: 572 HNEYNFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSIL--DENDDFTIDSQTGVIRPN 628
Query: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVC----EKTLYSDTI 3032
+ DREK+++Y + A DG + SS A V + V+D NDN PV Y +
Sbjct: 629 IS--FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL 686
Query: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQA 3091
P PG ++ Q+ A D D NAE+ Y+++G + F ++ +TG + D +
Sbjct: 687 P-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Query: 3092 VYHLLVRATDGGGRFCQASIVLTLEDVNDN 3121
++ +LV+A D G S+V+ VN++
Sbjct: 746 LHRVLVKANDLGQPDSLFSVVIVNLFVNES 775
Score = 235 bits (600), Expect = 7e-61
Identities = 209/706 (29%), Positives = 333/706 (47%), Gaps = 50/706 (7%)
Query: 2267 VFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
V + +++DINDN P+F +++ E S I + A D D N +Y++
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--- 179
Query: 2327 SKSHDHFHVD-------SSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVD 2379
KS + F +D + + + LD E+ + + V+ DGG P SS I+ V
Sbjct: 180 -KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYS---ILSGNDHK 2436
VTD NDN P+F++ E I E+AP G VT + A DAD + K+ +S ++S +
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF---RSSTQVHVTVIGGNLHSP--A 2491
F +++ TG+IT+ P + L + SDG R+ V+VT + N+ S
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358
Query: 2492 FLQNEYE--VELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFA-KDRFYINERGQI 2548
++ N V L+EN PL+T + + TD D+ G VT ++ + R + + +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 2549 FTLEKLDRETPAEKVISVRLMAKDAG----GKVAFCTVNVILTDDNDNAPQFRATKYEVN 2604
T LD E+ E +++L+A DAG + A + V D+NDNAP F + V+
Sbjct: 419 ETAAYLDYESTKE--YAIKLLAADAGKPPLNQSAMLFIKV--KDENDNAPVFTQSFVTVS 474
Query: 2605 IGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGL 2664
I + + G + KV A DAD G NA I Y + D+ ++ +G++T + L
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP---EFSLDCRTGMLTVVKKLDRE 531
Query: 2665 ENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDL 2724
+ + + F + A DNG P S V V+V I+ P F+ Y F V E++P + L
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 2725 IRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
I S V + + N D F ID Q+G ++ S D E + Y F + A
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKA---- 645
Query: 2785 DDHEMVA---SVDVSIQVKDANDNSPVFESSP----YEAFIVENLPGGSRVIQIRASDAD 2837
+D V+ S V+I V D NDN PVF P YE + PG + V Q+ A D D
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG-TVVFQVIAVDND 704
Query: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
+G N +V YS+ + ++ FAI+ ETG IT +++ D +++ V A+D G+
Sbjct: 705 TGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761
Query: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTT 2943
L S IV++ V + + + K T + P + + S T
Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPT 807
Score = 228 bits (581), Expect = 1e-58
Identities = 192/678 (28%), Positives = 319/678 (47%), Gaps = 56/678 (8%)
Query: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
++F V ++ +ED+NDN P F + + E+ + A DPD+G +G Y
Sbjct: 118 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 177
Query: 966 LLDHGEGNFDVDKLS-------GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
L+ + F +D + + + ++LD E+K Y + V+ +D G P SST +
Sbjct: 178 LI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAIL 235
Query: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD--- 1075
+V V D N+N PVF + ++ E+APVG+ V + A D D + +I +S +
Sbjct: 236 QVSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293
Query: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135
+F + TG+I + LDRE T ++ L V A+D G++P + + + V DVNDN
Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDN 351
Query: 1136 APQTS-----EPVYYPEIM-ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
P PV ++ EN P + + I D D+ N ++ P F +
Sbjct: 352 VPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRL 408
Query: 1190 HP--KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
P + T+ LD E E+ +++ D G PP + A + +K+ DENDN P F Q
Sbjct: 409 RPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 468
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
F + +PE P + L V A D D GPNA+I+Y + + +F ++ +TG
Sbjct: 469 SFVTVSIPENNSPGIQ-------LTKVSAMDADSGPNAKINYLL-GPDAPPEFSLDCRTG 520
Query: 1308 VVSSKRFSAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTF 1365
+++ + + D + +I A DNG P +S + + I + S P+ F + + F
Sbjct: 521 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS--PV-FTHNEYNF 577
Query: 1366 TVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSH--FDVDKGTGTIIVAKPLDAEQKS 1423
V E+ P +G+I+V P +T D + F +D TG I D E++
Sbjct: 578 YVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQE 637
Query: 1424 NYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQF----STSKYEVVIPEDTAPETEIL 1476
+Y V+A DG + + +V I V+D ND++P F S YE+V+P T P T +
Sbjct: 638 SYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTVVF 696
Query: 1477 QISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Q+ AVD D ++ Y++ + F +D TG++ EK D + H + V
Sbjct: 697 QVIAVDNDTGMNAEVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKA 753
Query: 1535 RDQDVPVKRNFARIVVNV 1552
D P F+ ++VN+
Sbjct: 754 NDLGQP-DSLFSVVIVNL 770
Score = 216 bits (551), Expect = 3e-55
Identities = 218/708 (30%), Positives = 325/708 (45%), Gaps = 57/708 (8%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----FDVVVEVTEEHKPSAVAHVV-VKVIVEDQNDN 2077
+I +G + TTG DRE+ A EV P + +V ++ ++ED NDN
Sbjct: 76 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135
Query: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIG----PLG 2133
AP+F + ++ + AVD D G NG +Y L + F + P G
Sbjct: 136 APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195
Query: 2134 E--ISLKKQFELDTLNKE-YLVTVVAKDGGNPAFSAEVI--VPITVMNKAMPVFEKPFYS 2188
+ L Q ELD K+ Y++ V +DGG P S+ I V +T N PVF++
Sbjct: 196 DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 2189 AEIAESIQVHSPVVHVQANSP---EGLKVFYS---ITDGDPFSQFTINFNTGVINVIAPL 2242
I E+ V + V + A E K+ +S + F +N TG+I + PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 2243 DFEAHPAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPP------VFAQQSYAVTLSEA 2295
D E P +KL + A+D L A A V V+ V D+NDN P + + V LSE
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQ 2355
+ T + + TD D++ N ++ F +H V S+ L+ LDYE +++
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKE 431
Query: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415
+ I + A D G P L+ ++ + V D NDN P+F Q I E+ G +T V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHALKPFYSLNLSVSDGV--F 2472
DADS K+ Y +L + F +D TG++T + L R + L+ +GV
Sbjct: 492 DADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 2473 RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV 2532
S+ V V++I N +SP F NEY + EN P H V + TD D G VT I+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 2533 NDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV-----AFCTVNVIL 2586
++ D F I ++ G I DRE V+ A+D GG+V A T+NV+
Sbjct: 611 DE--NDDFTIDSQTGVIRPNISFDREKQESYTFYVK--AED-GGRVSRSSSAKVTINVV- 664
Query: 2587 TDDNDNAPQF----RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
D NDN P F YE+ + S GT V +V+A D D G NA++ Y+I +
Sbjct: 665 -DVNDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG--NT 720
Query: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP-SKESVVLV 2689
++ I++ +G IT E + V+A D G P S SVV+V
Sbjct: 721 RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIV 768
Score = 209 bits (532), Expect = 5e-53
Identities = 188/646 (29%), Positives = 300/646 (46%), Gaps = 72/646 (11%)
Query: 422 ILEPVKRQQAAHFELEVTTSD----RKASTKVL-VKVLGANSNPPEFTQTAYKAAFDENV 476
+ + + R++ + ++V D +++ST +L V V N N P F +T + + EN
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 477 PIGTTVMSLSAVDPDEGENGYVTYSIANL-NHVPFAIDHF---TGAVSTSENLDYELMPR 532
P+GT+V L A D D GEN + +S +NL +++ + H TG ++ E LD E P
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 533 VYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVS 592
+ L + ASD GL R + VL +T ++NDN P +
Sbjct: 323 -HKLLVLASDGGLMPARAM-VLVNVT--DVNDNVPSID---------------------- 356
Query: 593 AIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA-TDGE 651
++Y + N+ S N L+ K +L+ + K + H+ R+T TD E
Sbjct: 357 ---------IRYIVNPVNDTVVLSENIP---LNTKIALIT-VTDKDADHNGRVTCFTDHE 403
Query: 652 NFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLH---NQGEVEDIFFDSHS 708
P + + L + K A KLL A+ NQ + +F
Sbjct: 404 ---IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKD 458
Query: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
N + P F + T + + EN G + +++ D D+G N K+ Y + G + F +D
Sbjct: 459 ENDNAPVFTQSFVT-VSIPENNSPGIQLTKVSAMDADSGPNAKINYLL-GPDAPPEFSLD 516
Query: 769 METGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYF 828
TGML ++ LDRE DKY I D G+P + + V ++D NDN P F Y
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 829 VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888
V E+ H + + TD D G N VT SI+ + D F+IDS TGV+ DRE Q
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQ 636
Query: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE---GTV 945
++ ++A D R S+ V +++ DVNDN P FI P LP GTV
Sbjct: 637 ESYTFYVKAEDGGRVSRS--SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTV 694
Query: 946 IMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
+ + A D D G + +VRYS++ + F +D+ +G + ++++ D ++ + V+A
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAN 754
Query: 1005 DKGKPVSLSSTCYVEVEVVDVNENL-HPPVFSSFVEKGTVKEDAPV 1049
D G+P SL S V + VNE++ + + + V K T +APV
Sbjct: 755 DLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKST---EAPV 794
Score = 196 bits (497), Expect = 6e-49
Identities = 208/764 (27%), Positives = 330/764 (43%), Gaps = 77/764 (10%)
Query: 1079 VGVFKIGEETG-VIETSDRLDREST-------SHYWLTVFATDQGVVPLSSF--IEIYIE 1128
V + +I E+TG + T R+DRE H + V + ++P F ++I
Sbjct: 72 VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEV---EVAILPDEIFRLVKIRFL 128
Query: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYK-ITSGNPQGFF 1187
+ED+NDNAP V I ENS + A DPD N Y+ I S N G
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1188 SIHPKTG-----LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
I G LI ++LDRE++D ++++V V D G P +S+ A + V + D NDN
Sbjct: 189 VIETPEGDKMPQLIV--QKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED---GNEHGK 1299
P F + ++ +PE + + ATD D G NA+I +S +
Sbjct: 247 PVFKETEIEVSIPENAPVGTS-------VTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 1300 FFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS 1357
F + TG+++ K E L + A D G + +++ ++ PS++ I
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID-IR 358
Query: 1358 FEESFFTFTVMESD--PVAHMIGVISVEPPGIPLWFDITG-GNYDSHF---DVDKGTGTI 1411
+ + TV+ S+ P+ I +I+V +T +++ F V +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 418
Query: 1412 IVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPED 1468
A LD E Y + + A D L Q +FIKV D ND+ P F+ S V IPE+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
+P ++ ++SA+D D K+ Y L P +F LD TG L +KLD E
Sbjct: 479 NSPGIQLTKVSAMDADSGPNAKINYLLGPDAPP----EFSLDCRTGMLTVVKKLDREKED 534
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTA 1586
++ T++ +D VP + + V++ D ND++P FT + Y V E+ V +T
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1587 LDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1646
D D G N+ V SI N + F ID G I+ DR Q Y VKA D G
Sbjct: 595 TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1647 MSEITSVRIFVTIADNASPKF----TSKEYSVELSETVSIGSFVGMVTA-----HSQSSV 1697
S V I V ++ P F ++ Y + L T + G+ V V A + V
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEV 711
Query: 1698 VYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS----------- 1746
Y I GNT D F I+ +G I + D L ++ ++++ ++
Sbjct: 712 RYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLF 771
Query: 1747 -----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785
TN T++ L ++ APV E + S ++ +++
Sbjct: 772 VNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILV 815
Score = 189 bits (479), Expect = 7e-47
Identities = 170/654 (25%), Positives = 288/654 (44%), Gaps = 67/654 (10%)
Query: 1948 YELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP 2007
YE+ V L ++ +++ ++ F V + + ENS + A+
Sbjct: 108 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 167
Query: 2008 INEPLFYHILNPDRRFKISRTSGV--LSTTGTP-------------FDREQQEAFDVVVE 2052
+ +N + +++ ++ + L TP DRE+++ + + V+
Sbjct: 168 VG-------INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 220
Query: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
V + P + +++V V D NDN PVF + + VG + + A D D G
Sbjct: 221 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 280
Query: 2113 NGEVHYYLKEHHEH-----FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
N ++H+ + F + G I++K+ + + L+ V+A DGG A
Sbjct: 281 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL-VLASDGGLMPARA 339
Query: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV-FYSITDGD--- 2222
V+V +T +N +P S +I + + V + N P K+ ++TD D
Sbjct: 340 MVLVNVTDVNDNVP-------SIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 392
Query: 2223 ------------PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFV 2269
PF + N ++ A LD+E+ Y + + A D+ + +
Sbjct: 393 NGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 452
Query: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
I V D NDN PVF Q V++ E + G + +V A D+DS PN I+Y + + +
Sbjct: 453 FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPD---A 509
Query: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389
F +D TG++++++ LD E+ ++ + A D G+P L+S+V V V + D NDN P+
Sbjct: 510 PPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV 569
Query: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
F Y + E+ P V + D D D + SIL ND F IDS TG+I
Sbjct: 570 FTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRP 627
Query: 2450 SNLHRHALKPFYSLNLSVSDG--VFRSST-QVHVTVIGGNLHSPAFL----QNEYEVELA 2502
+ + Y+ + DG V RSS+ +V + V+ N + P F+ YE+ L
Sbjct: 628 NISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP 687
Query: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555
P T+V +V D D+G+ V Y IV +D F I+ E G I +EK D
Sbjct: 688 STNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD 740
Score = 177 bits (448), Expect = 3e-43
Identities = 156/550 (28%), Positives = 252/550 (45%), Gaps = 52/550 (9%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE KD Y + VK + + T + +V V DTND P+F T VS+PEN + T
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD-----MFAIHPTSGVIVLTGRLDYLETKLYEME 221
S+ ++ ATDADIG N + ++SF + +F ++ T+G+I + LD ET +++
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI----------TAVTLSPSELDRDP 271
+LA+D G+ + + A + V++ N+ P I V LS + +
Sbjct: 327 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS-ENIPLNT 378
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFG 331
A++TV D D NG + + D FR F S ++ ++ +D++S
Sbjct: 379 KIALITVTDKDADHNGRVTCFT----DHEIPFRLRPVF--SNQFLLETAAYLDYESTK-E 431
Query: 332 YNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Y + L A D G PP S + + PV F + I E P + V A
Sbjct: 432 YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 392 IPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR---- 443
+ A S + Y+ +FSL+ TG++++++ + R++ + + D
Sbjct: 491 MDADSGPNAKINYLL-GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 549
Query: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
++ V V ++ N N P FT Y EN+P TV ++ DPD G+N VT SI
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
+ N F ID TG + + + D E YT ++A D G R TI + ++
Sbjct: 610 LDEND-DFTIDSQTGVIRPNISFDRE-KQESYTFYVKAEDGG-RVSRSSSAKVTINVVDV 666
Query: 563 NDNTPLF--EKINC--EGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFFS 616
NDN P+F NC E +P G + V A+D D V+Y I GN D F+
Sbjct: 667 NDNKPVFIVPPSNCSYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 617 LNPNSGVLSL 626
++ +G ++L
Sbjct: 726 IDQETGNITL 735
Score = 159 bits (401), Expect = 8e-38
Identities = 186/701 (26%), Positives = 313/701 (44%), Gaps = 59/701 (8%)
Query: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI--YTLQSS 1496
L ++ + D ND+ P F + + IPE++A ++ +AVD D + Y L S
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1497 RDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
++ L L ++LD E + + V V D P + + A + V+V+D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES--GNIGNS-FM 1611
TND+ P F + + + E+A VG+ V Q+ A D D G+NA++ +S + NI F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671
++ G I + LDR + L+V A+D G P + V + VT ++ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VLVNVTDVNDNVPSIDIRY 359
Query: 1672 YSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDA--------FDINP---HSGTII 1720
+++TV + + + T + +V + D N F + P + +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE 419
Query: 1721 TQKALDFETLPIYT--LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
T LD+E+ Y L+ L+ + + + ++DENDNAPVF Q+ T I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE 1838
S + LT + A DAD NA + Y ++ P F++D TG + V LD E
Sbjct: 480 S-PGIQLTK------VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1839 ETSIFHFTVQVHDMGTPRLFAEYAANVTVHV--IDINDCPPVFAKPLYEASL--LLPTYK 1894
+ + FT+ D G P L +NVTV V ID ND PVF Y + LP +
Sbjct: 532 KEDKYLFTILAKDNGVPPL----TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587
Query: 1895 GVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQLRSRYELTV 1952
V +ITV TD D S + SI + N + F++D +TG + + + + Y V
Sbjct: 588 TVGLITV--TDPDYGDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1953 RASD-GRFAGLTSVK-----INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGN 2006
+A D GR + +S K ++V ++K + + +V ++ + + A+ N
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 2007 P--INEPLFYHILNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP-SA 2061
+N + Y I+ + R F I + +G + T D V+V+ + +P S
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEKCDVTDLGLHRVLVKANDLGQPDSL 762
Query: 2062 VAHVVVKVIVEDQNDNAPV---FVNLPYYAVVKVDTEVGHV 2099
+ V+V + V + NA + V A V +TE+ V
Sbjct: 763 FSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADV 803
Score = 127 bits (318), Expect = 3e-28
Identities = 160/705 (22%), Positives = 273/705 (38%), Gaps = 83/705 (11%)
Query: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
K+R + D ND PLF T ++S+PEN+AI + +A D D+G NG Y +
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 194 MF---AIHPTSG----VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
+F I G +++ LD E Y M++ D G S+ I L V
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-----LQVS 238
Query: 247 IEQANECAPVITAVTLSPSELDRDPAYAIVT---VDDCDQGANGDI-ASLSIVAGDLLQQ 302
+ N+ PV + S + P VT D D G N I S S + ++ ++
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362
+ + G K +D + P + L + A D G P + V +++VT
Sbjct: 299 LFHLNATTGLITIKEP----LDREETP-NHKLLVLASDGGLMPARAMV-LVNVTDVNDNV 352
Query: 363 GPVKFEKDVYRAE----ISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLN--- 414
+ V +SE P NT + ++ H V T + F L
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 412
Query: 415 YNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYK 469
N L+ + + + +++ +D S + +KV N N P FTQ+
Sbjct: 413 SNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYEL 529
+ EN G + +SA+D D G N + Y + F++D TG ++ + LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREK 532
Query: 530 MPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQIT 589
+ Y I A D G+P V +++ + NDN+P+F +P +L +
Sbjct: 533 EDK-YLFTILAKDNGVPPLTS-NVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 590 TVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
++ D D + +E D F+++ +GV+ R + K ++ + A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVI---RPNISFDREKQESYTFYVKAED 647
Query: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
G + +T+ + + + + +F S
Sbjct: 648 GGRVSRSSSAKVTI----------------------------NVVDVNDNKPVFIVPPSN 679
Query: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDM 769
++ ST P G+ V + + D DTG N ++ Y++ GGN F ID
Sbjct: 680 CSYELVLPSTNP-----------GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 728
Query: 770 ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
ETG + ++ D + + + DLG P L VV+V+
Sbjct: 729 ETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS----LFSVVIVN 769
Score = 122 bits (305), Expect = 1e-26
Identities = 163/670 (24%), Positives = 281/670 (41%), Gaps = 67/670 (10%)
Query: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVV-----YE-IKD 1703
+ +R + ++ +P F + ++ + E +I S + A + YE IK
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181
Query: 1704 GNTGDAFDINPHSGT----IITQKALDFETLPIYTLIIQGTNMAGLSTNTTVL--VHLQD 1757
N I G +I QK LD E Y + ++ + ++T + V + D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY---HIVEP 1814
NDN PVF + E I E+A + + V + A DAD NA + + ++V
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQ-------LHATDADIGENAKIHFSFSNLVSN 294
Query: 1815 SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDIND 1874
F ++++TG I LD EET V D G A V V+V D+ND
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG----LMPARAMVLVNVTDVND 350
Query: 1875 CPP-----VFAKPLYEASLL---LPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEK 1926
P P+ + +L +P + +ITV DAD + + T+ I +
Sbjct: 351 NVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG---RVTCFTDHEIPFR 407
Query: 1927 ----FSMDY--KTGALTVQNTTQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHL 1977
FS + +T A +T+ Y + + A+D L + I VK+ ++
Sbjct: 408 LRPVFSNQFLLETAAYLDYESTK---EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAP 464
Query: 1978 KFTQDVYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILNPDR--RFKISRTSGVLS 2033
FTQ + + EN++ L ++A+ + N + Y +L PD F + +G+L
Sbjct: 465 VFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGML- 522
Query: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVD 2093
T DRE+++ + + + P ++V V V + DQNDN+PVF + Y V +
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2094 TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI-GPLGEISLKKQFELDTLNKEYLV 2152
+ +T D D G N V + + ++ F I G I F+ + + Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK-QESYTF 641
Query: 2153 TVVAKDGG--NPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP------VVHV 2204
V A+DGG + + SA+V + + +N PVF P + + +P V+ V
Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Query: 2205 QANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH 2264
++ +V YSI G+ F I+ TG I ++ D +++ ++A D G
Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQP 759
Query: 2265 AEVFVDIIVD 2274
+F +IV+
Sbjct: 760 DSLFSVVIVN 769
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 280 bits (715), Expect = 3e-74
Identities = 212/684 (30%), Positives = 318/684 (46%), Gaps = 58/684 (8%)
Query: 693 LHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKL 752
L Q EV+DI N + P F S + T + + EN +GS ++D D G NG
Sbjct: 152 LEGQIEVQDI-------NDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVA 203
Query: 753 VYAVSGGNE-DSCFMIDM------ETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAW 805
Y + G E F + + + L ++ LDRE D Y L I V D G P +A+
Sbjct: 204 SYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASS 263
Query: 806 RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT 865
LL V V+D NDN P+F + SY E+SE+ + +IQV+A D D G N + Y+
Sbjct: 264 ALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP 323
Query: 866 DT----FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN 921
+ +D TG++ + P+DRE + A+D+ + VVV V +D+N
Sbjct: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTV--KDMN 381
Query: 922 DNPPTF--------IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--------SGQVRYS 965
DN PT + + ED+ E T + ++ D D G+ +G V +
Sbjct: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441
Query: 966 LLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
L E D K ++ LD+EK + Y + + A D G P LSST ++V+VVDV
Sbjct: 442 LRQASETGSD-SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDV 499
Query: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR-DGSGVGVFKI 1084
N+N PVF+ V + E+ G ++ ++A D D+ + E+ YS+ + + G+F I
Sbjct: 500 NDN--APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557
Query: 1085 GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVY 1144
ETG I+ LDRE Y L V A D+G L + + V D NDN P+ Y
Sbjct: 558 SPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGY 617
Query: 1145 YPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLD 1204
+MEN P V + D D N ++ + N G F I TG I +S D
Sbjct: 618 NFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTI-LSSLSFD 674
Query: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL---QKFYKIRLPEREKPD 1261
REQQ + ++ D G PP+S V + +LDENDN P +K+ P+
Sbjct: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQ----- 729
Query: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD 1321
E + V A D D G NAE+ YSI GN +G F I +G ++ ++ +
Sbjct: 730 ---TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHG 786
Query: 1322 I--LSIKAVDNGRPQKSSTTRLHI 1343
+ L +K D G+P + T +H+
Sbjct: 787 LHRLVVKVSDRGKPPRYGTALVHL 810
Score = 246 bits (629), Expect = 3e-64
Identities = 202/673 (30%), Positives = 310/673 (46%), Gaps = 45/673 (6%)
Query: 3010 EVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGS--GA 3067
+++V D NDN+P + + IPE+ G L A+D D N +Y L
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 3068 EKFKLN------PDTGELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVN 3119
E F L +L LDRE Y L ++ DGG R A + +T+ D N
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 3120 DNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSAD---GQFSINE 3176
DNAP+F Y + EN+ G + +V+A D+D G N +I Y+ + + ++
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 3177 LSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYG 3236
+G+I ++ P+DRE + S+ A D+G + +A V+V+V D+NDN P E R G
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK-SARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 3237 --------ATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGA-- 3286
A +SED+ T V V + RD NA +T +++G+ + S+TG+
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGSDS 452
Query: 3287 --VFIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYT 3341
+ ++ LDYE +Y + + A D G P LS ++ V V D+NDN PVF+Q
Sbjct: 453 KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 3342 TVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDPVRGEVKVTKLLDR 3400
E+ + + + A DAD SN+ + YS+ FTI P GE++V LDR
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDR 572
Query: 3401 ETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVL 3460
E Y L V A+D GSP T TV ++V D NDN P F Y+ + EN P V
Sbjct: 573 EQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632
Query: 3461 QLVVTDEDSSHNGPPFFFTIVTGNDEKAFEV-NPQGVLLTSSAIKRKEKDHYLLQVKVAD 3519
+ V D D N + D F + N G +L+S + R+++ Y Q+K D
Sbjct: 633 MVTVIDGDKGENAQ---VQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 3520 NGKPQLSSLTYIDIRVIEESIYPPAILPLE--IFITSSGEEYSGGVIGKIHATDQD--VY 3575
G P S+ + I V++E+ P I + + G + ++ A D D V
Sbjct: 690 GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVN 749
Query: 3576 DTLTYSL-DPQMDNLFSVSSTGGKLIAHKKLD---IGQYLLNVSVTD-GKFTTVADITVH 3630
L YS+ LF + S G + K+++ G + L V V+D GK VH
Sbjct: 750 AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVH 809
Query: 3631 IRQVTQEMLNHTI 3643
+ V + + N T+
Sbjct: 810 L-YVNETLANRTL 821
Score = 225 bits (574), Expect = 7e-58
Identities = 181/657 (27%), Positives = 309/657 (47%), Gaps = 43/657 (6%)
Query: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI-VNDF 2535
Q+ V I N +P F + + EN + +L +D D+G G +Y +
Sbjct: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 2536 AKDRFYIN-------ERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTD 2588
A++ F + ++ Q+ + LDRE +++++ + + + + V + D
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 2589 DNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEI 2648
NDNAP+F YE + ++ G SV++V A+D+D+G+NA+I Y E V+ L +
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 2649 NKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKF----- 2703
++ +G+IT + + + F V A D G+ K + V V + P
Sbjct: 333 DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392
Query: 2704 ---SEPFYTFTVSEDVPIGTEIDLI----RAEHSGTVLYSLVKGNTPESNR--DESFVID 2754
+ +SEDV T + L+ R E + +V G+ P R E+
Sbjct: 393 GLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDS 452
Query: 2755 RQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPY 2814
++ L+ LD+E K Y I+A + + ++ + +QV D NDN+PVF S
Sbjct: 453 KKKYFLQTTTPLDYEKVKDYTIEIVA-VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511
Query: 2815 EAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKE 2874
E EN G + +I ASDADSG+N +++YSL+ + + + F I+ ETG I
Sbjct: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL--FTISPETGEIQVKTS 569
Query: 2875 LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG 2934
LD E+R++Y++KVVA+D G L TA V V V D ND+ P+F Y +V E+ P
Sbjct: 570 LDREQRESYELKVVAADRGSP-SLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
Query: 2935 GVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLL 2994
+ +++ D D E N QV + + G F ++ + DRE++ Y
Sbjct: 629 SPVGMVTVIDGDKGE-NAQVQLSVEQDN--GDFVIQ--NGTGTILSSLSFDREQQSTYTF 683
Query: 2995 TITATDGTFSSKAI---VEVKVLDANDNSPVCEKTLYSDTIPEDVLP----GKLIMQISA 3047
+ A DG ++ V + VLD NDN+P T S+T + + P G+ + Q++A
Sbjct: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAPYI--TAPSNTSHKLLTPQTRLGETVSQVAA 741
Query: 3048 TDADIRSNAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG 3103
D D NAE+ Y++ G F++ +G + ++R ++ L+V+ +D G
Sbjct: 742 EDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Score = 221 bits (563), Expect = 1e-56
Identities = 185/689 (26%), Positives = 318/689 (46%), Gaps = 75/689 (10%)
Query: 914 KVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN 973
++ ++D+NDN P F P + + E+ G++ A D D G +G Y L E
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 974 F--------DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
D ++ + ++ LD E+ Y+LT++ +D G P SS + V V+D
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL-LRVTVLDT 273
Query: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGV--GVFK 1083
N+N P F + + E++P+G V+ V A+D D + EI Y+ V + +
Sbjct: 274 NDNA--PKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLR 331
Query: 1084 IGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEP- 1142
+ TG+I +DRE S +V A D+G P S+ ++ + V+D+NDNAP
Sbjct: 332 LDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 1143 ---VYYPEIMENSPKDVS----VVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHP---- 1191
V + + M N +DV+ V ++ D D N + + P F +
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVP---FQLRQASET 448
Query: 1192 ----KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
K T+ LD E+ ++ +E+ D+G+PP S+ + V+++D NDN P F Q
Sbjct: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
Query: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE-DGNEHGKFFIEPKT 1306
++ PE KP E + + A+D D G NAE+ YS+E + G F I P+T
Sbjct: 509 SVTEVAFPENNKPG-------EVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPET 561
Query: 1307 GVVSSKRFSAAGEYDILSIKAV--DNGRPQKSSTTRLHIEWI----SKPKPSLEPISFEE 1360
G + K + + +K V D G P T + + + + PK F
Sbjct: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPK-------FML 614
Query: 1361 SFFTFTVMESDPVAHMIGVISV------EPPGIPLWFDITGGNYDSHFDVDKGTGTIIVA 1414
S + F+VME+ P +G+++V E + L + G+ F + GTGTI+ +
Sbjct: 615 SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNGTGTILSS 670
Query: 1415 KPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQF---STSKYEVVIPED 1468
D EQ+S Y ++A DG + V I V+D ND+ P S + ++++ P+
Sbjct: 671 LSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT 730
Query: 1469 TAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVH 1526
ET + Q++A D D +LIY++ + +P L F++ +G++ ++++
Sbjct: 731 RLGET-VSQVAAEDFDSGVNAELIYSI-AGGNPYGL--FQIGSHSGAITLEKEIERRHHG 786
Query: 1527 QHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
H L V V D+ P + A + + V++T
Sbjct: 787 LHRLVVKVSDRGKPPRYGTALVHLYVNET 815
Score = 218 bits (554), Expect = 1e-55
Identities = 185/672 (27%), Positives = 303/672 (45%), Gaps = 52/672 (7%)
Query: 1123 IEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG- 1181
+E IEV+D+NDN P + PV I EN+ A D D+ N Y++ +G
Sbjct: 152 LEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP 211
Query: 1182 NPQGFFSIH-------PKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVK 1234
Q F + + LI + LDRE+ D + L + V D GSPP+++ A + V
Sbjct: 212 EAQELFGLQVAEDQEEKQPQLIVMGN--LDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
Query: 1235 ILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDG 1294
+LD NDN P+F + Y+ L E + V A D D+G NAEI Y+
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHS-------VIQVKANDSDQGANAEIEYTFHQA 322
Query: 1295 NEHGKFFI--EPKTGVVSSKRFSAAGEYDIL--SIKAVDNGRPQKSSTTRL--HIEWISK 1348
E + + + TG+++ + + L S+ A D G KS+ ++ ++ ++
Sbjct: 323 PEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
Query: 1349 PKPSLEP-----ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFD-ITGGNYDSHF 1402
P++E ++ ++ + ++ A + +S G + G+
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442
Query: 1403 DVDKGTGT-------IIVAKPLDAEQKSNYNLTVEATDGTTTILTQ---VFIKVIDTNDH 1452
TG+ + PLD E+ +Y + + A D L+ + ++V+D ND+
Sbjct: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
Query: 1453 RPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN--KLIYTLQSSRDPLSLKKFRLDPA 1510
P F+ S EV PE+ P I +I+A D D + +L+Y+L+ +P + F + P
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP--EPAAKGLFTISPE 560
Query: 1511 TGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGR 1570
TG + LD E + L V+ D+ P + A ++VNV D ND+ P F S Y
Sbjct: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQ 1630
V E+ S V VT +D DKG+NA+V S+E N F+I G+I ++ DR Q
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQ 678
Query: 1631 AEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVE--LSETVSIGSFVGM 1688
+ Y +KA D G PP S V I V ++ +P T+ + L+ +G V
Sbjct: 679 STYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQ 738
Query: 1689 VTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA 1743
V A + ++Y I GN F I HSG I +K ++ ++ L+++ ++
Sbjct: 739 VAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Query: 1744 GLSTNTTVLVHL 1755
T LVHL
Sbjct: 799 KPPRYGTALVHL 810
Score = 216 bits (551), Expect = 3e-55
Identities = 209/747 (27%), Positives = 320/747 (42%), Gaps = 101/747 (13%)
Query: 1175 MYKITSGNPQGFFSIHPKTGLITTTSRKLDRE---------QQDEHIL--EVTVTD---N 1220
+YK+ G P + + KTG I TT +DRE D IL EV++TD N
Sbjct: 89 LYKLEVGAP--YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
Query: 1221 GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV-IATDK 1279
GSP + +++ D NDN P F + +PE N L+ + +A+D+
Sbjct: 147 GSP---RLLEGQIEVQDINDNTPNFASPVITLAIPE--------NTNIGSLFPIPLASDR 195
Query: 1280 DEGPNAEISYSIEDGNEHGKFF----------IEPKTGVVSSKRFSAAGEYDILSIKAVD 1329
D GPN SY ++ G E + F +P+ V+ + YD L+IK D
Sbjct: 196 DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD-LTIKVQD 254
Query: 1330 NGRPQKSSTTRLHIEWI----SKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP 1385
G P ++S+ L + + + PK FE + + E+ P+ H + +
Sbjct: 255 GGSPPRASSALLRVTVLDTNDNAPK-------FERPSYEAELSENSPIGHSVIQVKANDS 307
Query: 1386 GIPLWFDITGGNYDSH---------FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT 1436
+I Y H +D+ TG I V P+D E S +V A D T
Sbjct: 308 DQGANAEI---EYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
Query: 1437 ---TILTQVFIKVIDTNDHRPQFSTSKYEVV--------IPEDTAPETEILQISAVDQDE 1485
+ QV + V D ND+ P +V I ED A ET + + D+DE
Sbjct: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDE 424
Query: 1486 -KNKLIYTLQSSRDPLSLKKFRLDPATGS-------LYTSEKLDHEAVHQHTLTVMVRDQ 1537
+N + + + P L R TGS L T+ LD+E V +T+ ++ D
Sbjct: 425 GENAAVTCVVAGDVPFQL---RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDS 481
Query: 1538 DVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEV 1597
P + + V V D ND+AP FT S + E+ G V+ ++TA D D G NAE+
Sbjct: 482 GNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAEL 541
Query: 1598 LYSIESGNIGNS-FMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIF 1656
+YS+E F I P G I+ LDR + Y+L V A D+GSP + +V +
Sbjct: 542 VYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVN 601
Query: 1657 VTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA----HSQSSVVYEIKDGNTGDAFDI 1712
V ++ PKF Y+ + E + S VGMVT +++ V + + GD F I
Sbjct: 602 VLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVI 660
Query: 1713 NPHSGTIITQKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQAEY 1770
+GTI++ + D E YT ++ + + S V +++ DENDNAP
Sbjct: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720
Query: 1771 TG--LISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGA 1828
T L++ + V + A D D NA L+Y I + + F I S +GA
Sbjct: 721 TSHKLLTPQTRLGETVSQ-------VAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGA 773
Query: 1829 IHTVLSLDYEETSIFHFTVQVHDMGTP 1855
I ++ + V+V D G P
Sbjct: 774 ITLEKEIERRHHGLHRLVVKVSDRGKP 800
Score = 207 bits (527), Expect = 2e-52
Identities = 190/670 (28%), Positives = 298/670 (44%), Gaps = 41/670 (6%)
Query: 2271 IIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSH 2330
I V DINDN P FA + + E + IG+ A+D D+ PN SY++ ++
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG-PEAQ 214
Query: 2331 DHFHV------DSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLN 2384
+ F + + + ++ LD E+ + + ++ DGG P +S ++ V V D N
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 2385 DNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND--HKHFVIDS 2442
DN P FE+ YEA +SE++P GH V VKA D+D +++Y+ + + +D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 2443 ATGIITLSN-LHRHALKPFYSLNLSVSDGVFRSS--TQVHVTVIGGNLHSPAF------- 2492
TG+IT+ + R L L+ G S QV VTV N ++P
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGL 394
Query: 2493 -LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQ---- 2547
+ ++E+ T V V+ +D D G VT + D +E G
Sbjct: 395 VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKK 454
Query: 2548 ---IFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQFRATKYE 2602
+ T LD E K ++ ++A D+G T + V + D NDNAP F + E
Sbjct: 455 KYFLQTTTPLDYE--KVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 2603 VNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLI 2662
V + G + ++ ASDAD GSNA++ Y++E + + K I+ +G I K SL
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE-PAAKGLFTISPETGEIQVKTSLD 571
Query: 2663 GLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEI 2722
+ E + V A D GSPS + V V +L PKF Y F+V E++P + +
Sbjct: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPV 631
Query: 2723 DLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARC 2782
++ + V+ + + N D FVI +G + S D E Y F + A
Sbjct: 632 GMVTVIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSFDREQQSTYTFQLKA-V 688
Query: 2783 TQDDHEMVASVDVSIQVKDANDNSPVF--ESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
A V V+I V D NDN+P S+ + G V Q+ A D DSG
Sbjct: 689 DGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGV 748
Query: 2841 NGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSS 2900
N +++YS+ + F I +G IT KE++ +++ V SD G K
Sbjct: 749 NAELIYSIAGGNPYGL---FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG-KPPRYG 804
Query: 2901 TAIVDVTVTD 2910
TA+V + V +
Sbjct: 805 TALVHLYVNE 814
Score = 206 bits (525), Expect = 3e-52
Identities = 195/765 (25%), Positives = 327/765 (42%), Gaps = 52/765 (6%)
Query: 2024 KISRTSGVLSTTGTPFDREQQEA-----------FDVVVEVTEEHKPSAVAHVVVKVIVE 2072
++ +G + TT T DRE + V +T+ + + + ++ V+
Sbjct: 100 RVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159
Query: 2073 DQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLK---EHHEHF-- 2127
D NDN P F + + +T +G + A DRD+G NG Y L+ E E F
Sbjct: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGL 219
Query: 2128 QIGPLGEISLKKQFELDTLNKE----YLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPV 2181
Q+ E + + L++E Y +T+ +DGG+P ++ ++ +TV+ N P
Sbjct: 220 QVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPK 279
Query: 2182 FEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSITDGDPFSQ--FTINFNTGVI 2236
FE+P Y AE++E+ + V+ V+AN + ++ Y+ + ++ NTG+I
Sbjct: 280 FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLI 339
Query: 2237 NVIAPLDFEAHPAYKLSIRATDSLTG-AHAEVFVDIIVDDINDNPP--------VFAQQS 2287
V P+D E + S+ A D T A V + V D+NDN P + Q
Sbjct: 340 TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQD 399
Query: 2288 YAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGN---HSKSHDHFHVDSSTG-LIS 2343
+SE T+V V+ +D D N ++ + G+ + DS +
Sbjct: 400 GMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQ 459
Query: 2344 LLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHA 2403
LDYE+ + +TI + AVD G P LSS + V V D+NDN P+F Q + E E+
Sbjct: 460 TTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENN 519
Query: 2404 PHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKH-FVIDSATGIITLSNLHRHALKPFYS 2462
G + + A DADS +L YS+ K F I TG I + + Y
Sbjct: 520 KPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYE 579
Query: 2463 LNLSVSD---GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDG 2519
L + +D + + V V V+ N + P F+ + Y + EN P + V V DG
Sbjct: 580 LKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDG 639
Query: 2520 DSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAF 2579
D G V + D D N G I + DRE + ++ + + A+
Sbjct: 640 DKGENAQVQLSVEQDNG-DFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAY 698
Query: 2580 CTVNVILTDDNDNAPQFRA---TKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIE 2636
V + + D+NDNAP A T +++ + G +V +V A D D G NA++ Y+I
Sbjct: 699 VGVTINVLDENDNAPYITAPSNTSHKL-LTPQTRLGETVSQVAAEDFDSGVNAELIYSIA 757
Query: 2637 ADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPP 2696
+ +I SG IT ++ + + V+ D G P + LV++ +
Sbjct: 758 GGNP--YGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNET 815
Query: 2697 EMQLPKFSEPF-YTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKG 2740
++ D+ I + + R++ G +L+ +V G
Sbjct: 816 LANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAG 860
Score = 202 bits (514), Expect = 6e-51
Identities = 200/799 (25%), Positives = 332/799 (41%), Gaps = 95/799 (11%)
Query: 375 EISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH- 433
++ E PPNT + + A + + +++K G ++ TG I E ++
Sbjct: 63 KVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRE 122
Query: 434 -------------FELEVTTSDRKASTKVL---VKVLGANSNPPEFTQTAYKAAFDENVP 477
FE+ +T + S ++L ++V N N P F A EN
Sbjct: 123 CQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTN 182
Query: 478 IGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSE-----------NLD 526
IG+ A D D G NG +Y L P A + F V+ + NLD
Sbjct: 183 IGSLFPIPLASDRDAGPNGVASYE---LQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLD 239
Query: 527 YELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGE 586
E Y L I+ D G P R L +T+ + NDN P FE+ + E + + +G
Sbjct: 240 RERWDS-YDLTIKVQDGGSPPRAS-SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 587 QITTVSAIDADE--LQLVQYQIEAGNEL--DFFSLNPNSGVLSLKRSLMDGLGAKVSFHS 642
+ V A D+D+ ++Y E+ L+ N+G+++++ +
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPV------------ 345
Query: 643 LRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDI 702
D E+ +T + +V A + N + V + + A + E+ I
Sbjct: 346 ------DREDLST---LRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI----EIRGI 392
Query: 703 FFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNED 762
+H + E+ ++V + +D D G N + V+G D
Sbjct: 393 GLVTHQDGM------------ANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG---D 437
Query: 763 SCFMIDM--ETG-------MLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV 813
F + ETG L+ +PLD E YT+ I D G P ++ L V VV
Sbjct: 438 VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV 497
Query: 814 DANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT---FSI 870
D NDN P F Q V E+ + I ++ A+D D G N + YS+ + F+I
Sbjct: 498 DVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557
Query: 871 DSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPP 930
TG + + LDRE + + LK+ A D R P L T V V++ D NDN P F+
Sbjct: 558 SPETGEIQVKTSLDREQRESYELKVVAAD--RGSPSLQGTATVLVNVLDCNDNDPKFMLS 615
Query: 931 NYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD 990
Y V E++P + + + D D G++ QV+ S+ + G+F + +G + D
Sbjct: 616 GYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV-EQDNGDFVIQNGTGTILSSLSFD 674
Query: 991 FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
E++ Y ++A D G P S+ V + V+D N+N S + +G
Sbjct: 675 REQQSTYTFQLKAVDGGVPPR-SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVF 1110
V V+A D D+ + E+ YSI G+ G+F+IG +G I ++R + L V
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVK 793
Query: 1111 ATDQGVVPL--SSFIEIYI 1127
+D+G P ++ + +Y+
Sbjct: 794 VSDRGKPPRYGTALVHLYV 812
Score = 181 bits (460), Expect = 1e-44
Identities = 174/616 (28%), Positives = 273/616 (44%), Gaps = 62/616 (10%)
Query: 108 LNREVKDHYTLIVKALEKNTNVEARTKV-RVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
L+RE D Y L +K + + A + + RV VLDTND P F SY L EN+ I
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 167 SIARVSATDADIGTNGEFYYSFKDRTD----MFAIHPTSGVIVLTGRLDYLETKLYEMEI 222
S+ +V A D+D G N E Y+F + + + +G+I + G +D + +
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 223 LAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI-----------TAVTLSPSELDRDP 271
LA DR G++ S+ A++ V ++ N+ AP I + ++ +
Sbjct: 358 LAKDR-----GTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 272 AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGS---KEYKVKAIGGIDWDSH 328
A A+V V D D+G N A +VAGD+ Q R S GS K+Y ++ +D++
Sbjct: 413 AVALVQVSDRDEGENA--AVTCVVAGDVPFQLRQA-SETGSDSKKKYFLQTTTPLDYEKV 469
Query: 329 PFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVM 388
Y + + A D G PP SS + V F + V E P +
Sbjct: 470 K-DYTIEIVAVDSGNPP-LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527
Query: 389 VKAIPAYS----HLRYVFKSTP-GKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR 443
+ A A S L Y + P K F+++ TG I + + R+Q +EL+V +DR
Sbjct: 528 ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADR 587
Query: 444 -----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYV 498
+ + VLV VL N N P+F + Y + EN+P + V ++ +D D+GEN V
Sbjct: 588 GSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQV 647
Query: 499 TYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT 558
S+ N F I + TG + +S + D E YT +++A D G+P R V TI
Sbjct: 648 QLSVEQDNG-DFVIQNGTGTILSSLSFDRE-QQSTYTFQLKAVDGGVP-PRSAYVGVTIN 704
Query: 559 LNNLNDNTPLF--EKINCEGTIPRDLGVGEQITTVSAIDAD---ELQLVQYQIEAGNELD 613
+ + NDN P + +GE ++ V+A D D +L+ Y I GN
Sbjct: 705 VLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI-YSIAGGNPYG 763
Query: 614 FFSLNPNSGVLSLKRSLMDGLGAKVSFHSL-RITATDGENFATPLYINITVAASHKLVNL 672
F + +SG ++L++ + + H L R+ + P Y LV+L
Sbjct: 764 LFQIGSHSGAITLEKEI------ERRHHGLHRLVVKVSDRGKPPRY-------GTALVHL 810
Query: 673 QCEETGVAKMLAEKLL 688
ET + L E LL
Sbjct: 811 YVNETLANRTLLETLL 826
Score = 177 bits (449), Expect = 2e-43
Identities = 183/690 (26%), Positives = 298/690 (43%), Gaps = 69/690 (10%)
Query: 1444 IKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLK 1503
I+V D ND+ P F++ + IPE+T + A D+D + + + P + +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 1504 KFRLDPATGS------LYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTND 1557
F L A L LD E + LT+ V+D P + + A + V V DTND
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
Query: 1558 HAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGN--IGNSFMIDPV 1615
+AP F SY+ + E++ +G V+QV A D D+G NAE+ Y+ + +D
Sbjct: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
Query: 1616 LGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKF-------- 1667
G I +DR + + V A D+G+ P S V + V ++ +P
Sbjct: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
Query: 1668 TSKEYSVELSETVSIGSFVGMVTA----HSQSSVVYEIKDGNTGDAFDINPHSGT----- 1718
T ++ +SE V+ + V +V +++ V + G+ F + S T
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV--PFQLRQASETGSDSK 453
Query: 1719 ----IITQKALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDENDNAPVFMQAEYTG 1772
+ T LD+E + YT+ I + LS+ ++ V + D NDNAPVF Q
Sbjct: 454 KKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ----- 508
Query: 1773 LISESASINSVVLTDRNVP----LVIRAADADKDSNALLVYHI-VEPSVHTYFAIDSSTG 1827
S+ V + N P I A+DAD SNA LVY + EP+ F I TG
Sbjct: 509 ------SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 1828 AIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEAS 1887
I SLD E+ + V D G+P L + A V V+V+D ND P F Y S
Sbjct: 563 EIQVKTSLDREQRESYELKVVAADRGSPSL--QGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1888 LL--LPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGAL--TVQNTTQ 1943
++ +P V ++TV D D +Q+ S+ + N F + TG + ++ +
Sbjct: 621 VMENMPALSPVGMVTV--IDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDRE 676
Query: 1944 LRSRYELTVRASDGRF---AGLTSVKINVKESKES--HLKFTQDVYSAVVKENSTEAETL 1998
+S Y ++A DG + V INV + ++ ++ + ++ + ET+
Sbjct: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
Query: 1999 AVITA--IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVT 2054
+ + A + +N L Y I NP F+I SG + T +R +VV+V+
Sbjct: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795
Query: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNL 2084
+ KP +V + V + N + L
Sbjct: 796 DRGKPPRYGTALVHLYVNETLANRTLLETL 825
Score = 167 bits (422), Expect = 3e-40
Identities = 178/687 (25%), Positives = 281/687 (40%), Gaps = 67/687 (9%)
Query: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHI- 1811
+ +QD NDN P F T I E+ +I S+ +PL A+D D N + Y +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLF----PIPL---ASDRDAGPNGVASYELQ 208
Query: 1812 VEPSVHTYFAI------DSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANV 1865
P F + + + + +LD E + T++V D G+P + V
Sbjct: 209 AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
Query: 1866 TVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGN--I 1923
TV +D ND P F +P YEA L + G VI V A D+D A +++ Y+ + +
Sbjct: 269 TV--LDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326
Query: 1924 GEKFSMDYKTGALTVQ----------------------NTTQLRSRYELTVRASDGRFAG 1961
+D TG +TVQ N R++ +TV+ +
Sbjct: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386
Query: 1962 LTSVKINVKESKESHLKFTQDV-----YSAVVKENSTEAETLAVITAIGNPINEPLFYHI 2016
+ I + ++ ++DV + V + E E AV + + + +
Sbjct: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVP----FQL 442
Query: 2017 LNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQND 2076
S+ L TT TP D E+ + + + + + P + +KV V D ND
Sbjct: 443 RQASETGSDSKKKYFLQTT-TPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
Query: 2077 NAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEH---FQIGP-L 2132
NAPVF + + G VI +TA D DSG N E+ Y L+ F I P
Sbjct: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPET 561
Query: 2133 GEISLKKQFELDTLNKEYLVTVVAKDGGNPAF--SAEVIVPITVMNKAMPVFEKPFYSAE 2190
GEI +K + + + Y + VVA D G+P+ +A V+V + N P F Y+
Sbjct: 562 GEIQVKTSLDREQ-RESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 2191 IAESIQVHSP---VVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAH 2247
+ E++ SP V + + E +V S+ + F I TG I D E
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQ 678
Query: 2248 PAYKLSIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYA--VTLSEASVIGTSVVQ 2304
Y ++A D + A V V I V D NDN P S L+ + +G +V Q
Sbjct: 679 STYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQ 738
Query: 2305 VRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVD 2364
V A D DS N + Y + G + + F + S +G I+L + ++ H + V+ D
Sbjct: 739 VAAEDFDSGVNAELIYSIAGGN--PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Query: 2365 GGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
G P +V + V + N L E
Sbjct: 797 RGKPPRYGTALVHLYVNETLANRTLLE 823
Score = 160 bits (405), Expect = 3e-38
Identities = 171/649 (26%), Positives = 267/649 (41%), Gaps = 58/649 (8%)
Query: 2040 DREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHV 2099
DRE+ +++D+ ++V + P + +++V V D NDNAP F Y A + ++ +GH
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 2100 IRYVTAVDRDSGRNGEVHYYLKEHHEHFQ-----IGPLGEISLKKQFELDTLNKEYLVTV 2154
+ V A D D G N E+ Y + E + G I+++ + + L+ +V
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLS-TLRFSV 357
Query: 2155 VAKD-GGNP-AFSAEVIVPITVMNKAMPVFE--------KPFYSAEIAESIQVHSPVVHV 2204
+AKD G NP + A+V+V + MN P E A I+E + + V V
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 2205 Q-ANSPEGLKVFYS-ITDGDPFSQFTINFNTG-------VINVIAPLDFEAHPAYKLSIR 2255
Q ++ EG + + GD Q TG + PLD+E Y + I
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIV 477
Query: 2256 ATDS----LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSD 2311
A DS L+ ++ + + V D+NDN PVF Q V E + G + ++ A+D+D
Sbjct: 478 AVDSGNPPLSSTNS---LKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 2312 SEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLS 2371
S N + Y + + F + TG I + +LD EQ + + V A D G P+L
Sbjct: 535 SGSNAELVYSL-EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
Query: 2372 SDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILS 2431
V V+V D NDN P F Y + E+ P V V D D + ++Q S+
Sbjct: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV-- 651
Query: 2432 GNDHKHFVIDSATGIITLSNLHRHALKPFYSLNL-SVSDGVFRSSTQVHVT--VIGGNLH 2488
D+ FVI + TG I S + Y+ L +V GV S V VT V+ N +
Sbjct: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
Query: 2489 SPAFL--QNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERG 2546
+P N L L V +V D DSG+ + Y I F I
Sbjct: 712 APYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHS 771
Query: 2547 QIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIG 2606
TLEK E RL+ K D P++ + +
Sbjct: 772 GAITLEK---EIERRHHGLHRLVVK---------------VSDRGKPPRYGTALVHLYVN 813
Query: 2607 SSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVI 2655
+ A T + +L D + DI E + + N+ ++GV+
Sbjct: 814 ETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVV 862
Score = 129 bits (324), Expect = 7e-29
Identities = 158/715 (22%), Positives = 283/715 (39%), Gaps = 95/715 (13%)
Query: 136 RVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFK---DRT 192
+++V D ND P F+ ++++PENT I + A+D D G NG Y + +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 193 DMFAIHPTSG------VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH 246
++F + +++ G LD Y++ I D GS +S A L V
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-----GSPPRASSALLRVT 269
Query: 247 IEQANECAPVITAVTLSPSELDRDP-AYAIVTV--DDCDQGANGDIASLSIVAGDLLQQF 303
+ N+ AP + + P ++++ V +D DQGAN +I A +++++
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 304 RTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAG 363
+ G + G +D + ++ AKD+GT P+ + +V+
Sbjct: 330 LRLDRNTG----LITVQGPVDREDLS-TLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNA 384
Query: 364 PVKFEKDV-------YRAEISEFAPPNTPVVMVKAIPA-YSHLRYVFKSTPGKAKFSLNY 415
P + + A ISE T V +V+ V G F L
Sbjct: 385 PTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQ 444
Query: 416 --NTG-------LISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPP 461
TG + P+ ++ + +E+ D ++ + V+V+ N N P
Sbjct: 445 ASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504
Query: 462 EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--FAIDHFTGAV 519
FTQ+ + AF EN G + ++A D D G N + YS+ F I TG +
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 520 STSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL--NDNTPLFEKINCEGT 577
+LD E Y L++ A+D G P ++ AT+ +N L NDN P F +
Sbjct: 565 QVKTSLDRE-QRESYELKVVAADRGSP---SLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
+ ++ + V+ ID D+ + Q Q+ + F + +G + S + +
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTI---LSSLSFDREQ 677
Query: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
S ++ ++ A DG Y+ +T+ +E A + ++KL
Sbjct: 678 QSTYTFQLKAVDGGVPPRSAYVGVTINV--------LDENDNAPYITAPSNTSHKLLT-- 727
Query: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
PQ R +G +V + + D D+G N +L+Y+++
Sbjct: 728 ----------------PQTR--------------LGETVSQVAAEDFDSGVNAELIYSIA 757
Query: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVV 812
GGN F I +G + + ++R + L + V D G P + L+H+ V
Sbjct: 758 GGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 97.4 bits (241), Expect = 3e-19
Identities = 67/215 (31%), Positives = 95/215 (44%), Gaps = 25/215 (11%)
Query: 3280 IDSKTGAVFIIE-NLDYESSHEYY-----------LTVEATD---GGTPSLSDVATVNVN 3324
+D KTG +F E ++D E E V TD G+P L + +
Sbjct: 101 VDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIE 157
Query: 3325 VTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSF- 3383
V DINDNTP F+ T I E+ + +A D D N Y + G +
Sbjct: 158 VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF 217
Query: 3384 ------TIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNA 3437
+ + ++ V LDRE Y LT++ D GSPPR ++ + + V D NDNA
Sbjct: 218 GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNA 277
Query: 3438 PVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHN 3472
P F R +Y + EN P+G SV+Q+ D D N
Sbjct: 278 PKFERPSYEAELSENSPIGHSVIQVKANDSDQGAN 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 176,382,835
Number of Sequences: 37866
Number of extensions: 8460345
Number of successful extensions: 68671
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 311
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 23270
Number of HSP's gapped (non-prelim): 7062
length of query: 4588
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4465
effective length of database: 13,590,000
effective search space: 60679350000
effective search space used: 60679350000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.