Guide to the Human Genome
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Search of human proteins with 134244285

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134244285 Notch homolog 3 [Homo sapiens]
         (2321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134244285 Notch homolog 3 [Homo sapiens]                          5103   0.0  
gi|148833508 notch1 preproprotein [Homo sapiens]                     2486   0.0  
gi|24041035 notch 2 preproprotein [Homo sapiens]                     2469   0.0  
gi|55770876 notch4 preproprotein [Homo sapiens]                      1173   0.0  
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               530   e-150
gi|4557679 jagged 1 precursor [Homo sapiens]                          517   e-146
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               477   e-134
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               462   e-129
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      461   e-129
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               453   e-126
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      446   e-125
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      446   e-124
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     443   e-123
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 351   5e-96
gi|112420992 crumbs homolog 2 [Homo sapiens]                          336   1e-91
gi|110347437 latent transforming growth factor beta binding prot...   305   3e-82
gi|110347412 latent transforming growth factor beta binding prot...   305   3e-82
gi|110347431 latent transforming growth factor beta binding prot...   305   3e-82
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               279   2e-74
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              279   3e-74
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   269   2e-71
gi|110735443 delta-like 1 [Homo sapiens]                              268   5e-71
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           266   2e-70
gi|148886654 polydom [Homo sapiens]                                   265   3e-70
gi|4557733 latent transforming growth factor beta binding protei...   256   2e-67
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   240   1e-62
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              238   4e-62
gi|46249414 latent transforming growth factor beta binding prote...   227   1e-58
gi|46249412 latent transforming growth factor beta binding prote...   227   1e-58
gi|194328809 latent transforming growth factor beta binding prot...   219   2e-56

>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 5103 bits (13236), Expect = 0.0
 Identities = 2321/2321 (100%), Positives = 2321/2321 (100%)

Query: 1    MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPS 60
            MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPS
Sbjct: 1    MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPS 60

Query: 61   REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP 120
            REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP
Sbjct: 61   REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP 120

Query: 121  DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180
            DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS
Sbjct: 121  DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180

Query: 181  FRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC 240
            FRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC
Sbjct: 181  FRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC 240

Query: 241  PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSC 300
            PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSC
Sbjct: 241  PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSC 300

Query: 301  VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360
            VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC
Sbjct: 301  VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360

Query: 361  HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG 420
            HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG
Sbjct: 361  HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG 420

Query: 421  RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVN 480
            RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVN
Sbjct: 421  RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVN 480

Query: 481  GGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT 540
            GGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT
Sbjct: 481  GGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT 540

Query: 541  LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
            LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL
Sbjct: 541  LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600

Query: 601  VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE 660
            VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE
Sbjct: 601  VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE 660

Query: 661  CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVC 720
            CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVC
Sbjct: 661  CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVC 720

Query: 721  EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPC 780
            EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPC
Sbjct: 721  EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPC 780

Query: 781  EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG 840
            EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG
Sbjct: 781  EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG 840

Query: 841  YTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT 900
            YTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT
Sbjct: 841  YTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT 900

Query: 901  CTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
            CTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ
Sbjct: 901  CTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960

Query: 961  HEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA 1020
            HEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA
Sbjct: 961  HEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA 1020

Query: 1021 YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH 1080
            YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH
Sbjct: 1021 YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH 1080

Query: 1081 CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDL 1140
            CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDL
Sbjct: 1081 CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDL 1140

Query: 1141 VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL 1200
            VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL
Sbjct: 1141 VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL 1200

Query: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQ 1260
            RCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQ
Sbjct: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQ 1260

Query: 1261 CRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLS 1320
            CRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLS
Sbjct: 1261 CRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLS 1320

Query: 1321 GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPE 1380
            GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPE
Sbjct: 1321 GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPE 1380

Query: 1381 VSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS 1440
            VSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS
Sbjct: 1381 VSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS 1440

Query: 1441 RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC 1500
            RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC
Sbjct: 1441 RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC 1500

Query: 1501 ASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560
            ASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR
Sbjct: 1501 ASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560

Query: 1561 PSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERL 1620
            PSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERL
Sbjct: 1561 PSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERL 1620

Query: 1621 DFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGF 1680
            DFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGF
Sbjct: 1621 DFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGF 1680

Query: 1681 SLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMG 1740
            SLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMG
Sbjct: 1681 SLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMG 1740

Query: 1741 AEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCG 1800
            AEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCG
Sbjct: 1741 AEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCG 1800

Query: 1801 GALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLD 1860
            GALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLD
Sbjct: 1801 GALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLD 1860

Query: 1861 AGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEG 1920
            AGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEG
Sbjct: 1861 AGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEG 1920

Query: 1921 MVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAA 1980
            MVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAA
Sbjct: 1921 MVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAA 1980

Query: 1981 REGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLG 2040
            REGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLG
Sbjct: 1981 REGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLG 2040

Query: 2041 PLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLS 2100
            PLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLS
Sbjct: 2041 PLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLS 2100

Query: 2101 PVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSL 2160
            PVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSL
Sbjct: 2101 PVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSL 2160

Query: 2161 GLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEE 2220
            GLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEE
Sbjct: 2161 GLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEE 2220

Query: 2221 YPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAM 2280
            YPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAM
Sbjct: 2221 YPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAM 2280

Query: 2281 ATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA 2321
            ATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA
Sbjct: 2281 ATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA 2321


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score = 2486 bits (6443), Expect = 0.0
 Identities = 1194/2300 (51%), Positives = 1484/2300 (64%), Gaps = 197/2300 (8%)

Query: 21   PPPVRALPLLLLLAGPGAAAPPCLD-GSPCANGGRCTQLPSREAACLCPPGWVGERCQLE 79
            PP +  L  L LL    A  P C   G  C NGG+C      EA C+C   +VG RCQ  
Sbjct: 2    PPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEA-CVCGGAFVGPRCQDP 60

Query: 80   DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP------------------- 120
            +PC S PC   G C      G A ++C C  GF GP C  P                   
Sbjct: 61   NPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLL 120

Query: 121  ---------------------DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDV 159
                                 DPC S+PCA+G +C +  +  ++C CPP + G +CR DV
Sbjct: 121  TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQC-LPFEASYICHCPPSFHGPTCRQDV 179

Query: 160  DECRVGEP---CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216
            +EC  G+    CRHGGTC N  GS+RC C A +TGP CE P VPC+PSPC+NGGTCR +G
Sbjct: 180  NEC--GQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG 237

Query: 217  DLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVD 276
            D+T++CACLPGF GQNCE N+DDCPG+ C NGG CVDGVNTYNC+CPPEWTGQ+CTEDVD
Sbjct: 238  DVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVD 297

Query: 277  ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASF 336
            ECQL PNAC NGGTC NT GG++CVCVNGWTGE CS+NIDDCA+A CFHGATCHDRVASF
Sbjct: 298  ECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASF 357

Query: 337  YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
            YC CP G+TGLLCHL+DAC+SNPC+E + CDTNPVNG+AICTCP G+TG AC QDVDECS
Sbjct: 358  YCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECS 417

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCI 456
            +GANPCEH G+C+NT GSF CQC +GYTGPRCE DVNEC+S PC+N ATCLD+IG+F CI
Sbjct: 418  LGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCI 477

Query: 457  CMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC 516
            CM G+ G +CEV+ DEC SSPC++ G C D++N F C CP+GF+G  CQ DVDECASTPC
Sbjct: 478  CMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPC 537

Query: 517  RNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTG 576
            +NGAKC+D P+ Y C C EG+ GT C+ ++D+C PDPCH+G C DG+A+F+C C PGYTG
Sbjct: 538  KNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTG 597

Query: 577  TRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRD 636
              CE+ ++EC SQPCRHGG C D  + YLC C  GTTG NCE+N+DDCAS+PC  G C D
Sbjct: 598  HHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLD 657

Query: 637  GINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPS 696
             I+ Y+C C+PG+TG +CN+ I+ECA +PC  GG+C DG NGF C CP G   P CL   
Sbjct: 658  KIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEV 717

Query: 697  HPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGF 756
            + C   PC HG C D+  G++C C+PGWSG  C   +  + CES PC  GGTC     G+
Sbjct: 718  NECNSNPCVHGACRDSLNGYKCDCDPGWSGTNC--DINNNECESNPCVNGGTCKDMTSGY 775

Query: 757  HCTCPPGVQGRQCE---------------------------------------LLSPCTP 777
             CTC  G  G  C+                                       +L+PC P
Sbjct: 776  VCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAP 835

Query: 778  NPCEHGGRC-ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCT 836
            +PC +GG C +S   +   C CP GWQG  C+ D++EC   +PC     C N  G + C 
Sbjct: 836  SPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECV-LSPCRHGASCQNTHGGYRCH 894

Query: 837  CHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC 896
            C  GY+G +C+ DI+DC PNPC NGGSC DG+ +  C CLPGF G  C  D++EC S+PC
Sbjct: 895  CQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPC 954

Query: 897  GPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYT 955
              G  CTD V S+TCTCP G+ G HCE + PDC+ SSCFNGGTCVDG+NSF+CLC PG+T
Sbjct: 955  RNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFT 1014

Query: 956  GAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC 1015
            G++CQH+ + C S+PCLHGG C      +RCTC + +TGP CQ LV WC   PC+NGG+C
Sbjct: 1015 GSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKC 1074

Query: 1016 VQTGAY--CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCP 1073
             QT     C CP GW+G  CD+ S+ C  AA + GV + +LCQ GG CVD  ++H+C C 
Sbjct: 1075 WQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQ 1134

Query: 1074 EGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQH 1133
             G TGS+CE  VD C   PCQ+G TC  Y+GGY C+C+ GY+G NC +++DEC S PCQ+
Sbjct: 1135 AGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQN 1194

Query: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG-PPLDSGPRCLHNGTCVDLVGGFRCT 1192
            GG+C+DL   Y CSCP GT GV CEIN DDC P   P+   P+C +NGTCVD VGG+ CT
Sbjct: 1195 GGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCT 1254

Query: 1193 CPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            CPPG+ G RCE D+NEC S  C A  T++C+Q     F C C AG +G RC++V++ C+ 
Sbjct: 1255 CPPGFVGERCEGDVNECLSNPCDARGTQNCVQRV-NDFHCECRAGHTGRRCESVINGCKG 1313

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
            +PC++GG C  +     G  F C C   F G  CE  AR+C  L+C  G  C   PR P 
Sbjct: 1314 KPCKNGGTCAVASNTARG--FICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPT 1371

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372
            C C    +GP C+ FP S P          PC + G+C P   +PF+RC C   + G  C
Sbjct: 1372 CLCLGPFTGPECQ-FPASSP-----CLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLC 1425

Query: 1373 E---------APAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGD 1423
                      A    P    E  C    CQ   G++ C  +CN+  CGWDGGDCSL+  D
Sbjct: 1426 HILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFND 1485

Query: 1424 PWRQC-EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADG 1482
            PW+ C ++LQCW+ F++  CD  C+S  CL+D FDC     E  CNP+Y++YC DHF+DG
Sbjct: 1486 PWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRA--EGQCNPLYDQYCKDHFSDG 1543

Query: 1483 RCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTS 1542
             CDQGCN+ EC WDGLDCA  VP  LA G LV+ VL+PPE+L  SS  FL+ LS +L T+
Sbjct: 1544 HCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTN 1603

Query: 1543 LRFRLDAHGQAMVFPYH------RPSP-------------------------GSE-PRAR 1570
            + F+ DAHGQ M+FPY+      R  P                         GSE  R R
Sbjct: 1604 VVFKRDAHGQQMIFPYYGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRR 1663

Query: 1571 RELAP-EVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDV 1629
            REL P +V GS+V LEIDNR C+Q+  +  CF  A   A +LGAL+++  L+ PY +  V
Sbjct: 1664 RELDPMDVRGSIVYLEIDNRQCVQA--SSQCFQSATDVAAFLGALASLGSLNIPYKIEAV 1721

Query: 1630 RGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVAR-RKREHSTLWFPEGFSLHKDVAS 1688
            + E +EPP P+      + A A +LL  +  GV+++R R+R+H  LWFPEGF + +   +
Sbjct: 1722 QSETVEPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSE---A 1778

Query: 1689 GHKGRREPVGQDALGMKNM--AKGESLMGEVATDWMDTECPEAKRLKVEEPGM--GAEEA 1744
              K RREP+G+D++G+K +  A   +LM +   +W D +  E K+ + EEP +    ++ 
Sbjct: 1779 SKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDL-ETKKFRFEEPVVLPDLDDQ 1837

Query: 1745 VDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALE 1804
             D RQWTQ HL AAD+R++ AMA TPPQG+ DAD MDVNVRGPDGFTPLM+AS  GG LE
Sbjct: 1838 TDHRQWTQQHLDAADLRMS-AMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLE 1896

Query: 1805 PMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGAD 1864
               +EE+E    + ++ISD I QGA L  +TDRTGETALHLAARY+R+DAAKRLL+A AD
Sbjct: 1897 TGNSEEEE---DAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASAD 1953

Query: 1865 TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEE 1924
             N QD+ GRTPLH AV+ADAQGVFQILIRNR+TDLDARM DG+T LILAARLAVEGM+E+
Sbjct: 1954 ANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLED 2013

Query: 1925 LIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGS 1984
            LI SHADVNAVD+LGKSALHWAAAVNNV+A + LLKNGANKDMQ+++EETPLFLAAREGS
Sbjct: 2014 LINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGS 2073

Query: 1985 YEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPP-------GPH 2037
            YE AK+LLDHFANR+ITDH+DRLPRD+AQER+H DIVRLLD+ +  RSP        G  
Sbjct: 2074 YETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTP 2133

Query: 2038 GLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRG----KKLTLACPGPLA 2093
             L P LC P  +L  LK    G KK R+P  K GL       +     +K +    G L 
Sbjct: 2134 TLSPPLCSPNGYLGSLKPGVQG-KKVRKPSSK-GLACGSKEAKDLKARRKKSQDGKGCLL 2191

Query: 2094 DSSVTLSPVDSLDSPRPF----GGPPASPGGF------PLE----------GPYAAATAT 2133
            DSS  LSPVDSL+SP  +      PP  P  F      PL           G      A 
Sbjct: 2192 DSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGHLNVAA 2251

Query: 2134 AVSLAQLGGPGRAGLGRQPP 2153
               +A LGG GR      PP
Sbjct: 2252 KPEMAALGGGGRLAFETGPP 2271



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 161/616 (26%), Positives = 232/616 (37%), Gaps = 120/616 (19%)

Query: 1757 AADIRVAPAMALTPPQG--DADADGM----------DVNVRGPDGFTPLMLASFCGGALE 1804
            +AD  +   M  TP      ADA G+          D++ R  DG TPL+LA+    A+E
Sbjct: 1951 SADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARL--AVE 2008

Query: 1805 PMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGAD 1864
             M              + DLI   A + A  D  G++ALH AA     DAA  LL  GA+
Sbjct: 2009 GM--------------LEDLINSHADVNA-VDDLGKSALHWAAAVNNVDAAVVLLKNGAN 2053

Query: 1865 TNAQDHSGRTPLHTAVTADAQGVFQILIRN-RSTDLDARMADGSTALILAARLAVEGMVE 1923
             + Q++   TPL  A    +    ++L+ +  + D+   M        L   +A E M  
Sbjct: 2054 KDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDR------LPRDIAQERMHH 2107

Query: 1924 ELIASHADVNAV--DELGKSALHWAAAVN----NVEATLALLKNG---------ANKDMQ 1968
            +++    + N V   +L  + L     ++    +    L  LK G         ++K + 
Sbjct: 2108 DIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLA 2167

Query: 1969 DSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDR---LPRDVAQERL------HQD 2019
               +E     A R+ S +    LLD        D L+       DVA   L         
Sbjct: 2168 CGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSP 2227

Query: 2020 IVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPG--LKAAQSGSKKSRRPPGKAGLGPQGP 2077
             V L   P  P +  G   L     P  A L G    A ++G  +    P  +G      
Sbjct: 2228 SVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLG 2287

Query: 2078 RGRGKKLTLACPGP--LADSSVTLSPVDSLDSPRPFGGPPAS--PGGFPLEGP------- 2126
               G  L     G   L      LS + S   P  +     S  PG    + P       
Sbjct: 2288 SSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAPSLQHGMV 2347

Query: 2127 ---YAAATATAVS-LAQLGGPGRAGLGRQP---------PGGCVLSLGLLNPVAVPLDWA 2173
               +++  A+A+S +    G     L  QP         P    +    L P  +    +
Sbjct: 2348 GPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQS 2407

Query: 2174 RLPPPAPPGP--------------SFLL--PLAPGPQLLNPGT----PVSPQERP----- 2208
              PPP PP P              SFL   P     Q L P +     + PQE P     
Sbjct: 2408 LQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQESPALPTS 2467

Query: 2209 -PPYLAVPGHGEEY---PAAGAHSSP---PKARFLRVPSEHPYLTPSPESPEHWASPSPP 2261
             P  L  P    ++   P+  ++SSP     +  L+VP EHP+LTPSPESP+ W+S SP 
Sbjct: 2468 LPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVP-EHPFLTPSPESPDQWSSSSPH 2526

Query: 2262 S-LSDWSESTPSPATA 2276
            S +SDWSE   SP T+
Sbjct: 2527 SNVSDWSEGVSSPPTS 2542


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score = 2469 bits (6398), Expect = 0.0
 Identities = 1214/2488 (48%), Positives = 1526/2488 (61%), Gaps = 277/2488 (11%)

Query: 17   PPPPPPPVRALPLLLLLAGPGAAAPPCLDG-SPCANGGRCTQLPSREAACLCPPGWVGER 75
            P   P  + AL  L L     A A  C DG  PC N G C    +    C CP G++GE 
Sbjct: 2    PALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEY 61

Query: 76   CQLEDPCHSGPCAGRGVCQSSVVAGTAR-------------------------------- 103
            CQ  DPC    C   G C +  + G A                                 
Sbjct: 62   CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC 121

Query: 104  -------FSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
                   + C C  GF G +C   D CLS PCA+G+ C+   + +F C C  G+ G+ C 
Sbjct: 122  HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVAN-QFSCKCLTGFTGQKCE 180

Query: 157  SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216
            +DV+EC +   C+HGGTCLN PGS++CQCP G+TG  C++  VPCAPSPC NGGTCRQ+G
Sbjct: 181  TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTG 240

Query: 217  DLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVD 276
            D T++C CLPGFEG  CE N+DDCP HRC NGG CVDGVNTYNC+CPP+WTGQFCTEDVD
Sbjct: 241  DFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD 300

Query: 277  ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASF 336
            EC LQPNAC NGGTC N  GG+ CVCVNGW+G+ CS+NIDDCA A C  G+TC DRVASF
Sbjct: 301  ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF 360

Query: 337  YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
             C CP GK GLLCHLDDAC+SNPCH+ A+CDTNP+NG+ ICTCP G+ G  C +DVDEC+
Sbjct: 361  SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA 420

Query: 397  IG-ANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
            +  +NPCEH G+CVNT G+F C+C +GY GPRCE D+NEC S PC+N ATCLD+IG FTC
Sbjct: 421  MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC 480

Query: 456  ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTP 515
            +CM GF G +CE++I+ECQS+PCVN G C D+VN F C CP GF+G  CQ+D+D+C+STP
Sbjct: 481  LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP 540

Query: 516  CRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYT 575
            C NGAKC+D P+GYEC+CA GF G LC+ N+D+C PDPCHHG+C DGI S++C C PGY 
Sbjct: 541  CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM 600

Query: 576  GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCR 635
            G  C  Q+DEC S PC + G+C+DLV+ Y C C  GT+GVNCE+N DDCASNPC  G+C 
Sbjct: 601  GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICM 660

Query: 636  DGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPP 695
            DGINRY CVC PGFTG  CN++I+ECAS+PC +G +C++G NGFRC+CP G   P C   
Sbjct: 661  DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ 720

Query: 696  SHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMG 755
             + C   PC HG C     G++C+C+ GW G  C   + ++ C S PC+ GGTC +   G
Sbjct: 721  VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCE--VDKNECLSNPCQNGGTCDNLVNG 778

Query: 756  FHCTCPPGVQGRQCEL---------------------------------------LSPCT 776
            + CTC  G +G  C++                                       L+PC+
Sbjct: 779  YRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCS 838

Query: 777  PNPCEHGGRCESAPG-QLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
            PNPCE+   C+ +P  +   C C  GWQG RC  D+DEC    PC  HG+C N  GS+ C
Sbjct: 839  PNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISK-PCMNHGLCHNTQGSYMC 897

Query: 836  TCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895
             C  G++G  C++DI+DC  NPC NGGSC DGV +FSC CLPGF G +C  D++ECLS P
Sbjct: 898  ECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEP 957

Query: 896  C-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY 954
            C   GTC+D+V S+TC C  G+ G HCE ++ +C+ SSCFNGGTCVDG+NSFSCLC  G+
Sbjct: 958  CKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGF 1017

Query: 955  TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGR 1014
            TG+ C HE + C S PCL+ G C      +RC+C   +TG  CQTLV+ CSR PC+N G 
Sbjct: 1018 TGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGT 1077

Query: 1015 CVQTGA--YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVC 1072
            CVQ  A   CLCP GW+G  CD+ ++ C  AA++ GV +E LCQ  G C++  ++HYC C
Sbjct: 1078 CVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC 1137

Query: 1073 PEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQ 1132
            P G TGS+CE+++D C + PCQHG TC  ++GGY CEC+PGY G NCE +VDEC +QPCQ
Sbjct: 1138 PLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQ 1197

Query: 1133 HGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT 1192
            +GG+CIDLV  + CSCPPGT G+LCE N DDC        GP CL+ G C+D +GG+ C 
Sbjct: 1198 NGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCA------RGPHCLNGGQCMDRIGGYSCR 1251

Query: 1193 CPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            C PG+ G RCE DINEC S  C +  + DC+Q     + C+C + F+G  C+T +  C  
Sbjct: 1252 CLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCPQ 1310

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
             PC +GG C  +     G  F C C   F G RC+    SC +++C  G  C  T  GPR
Sbjct: 1311 MPCLNGGTCAVASNMPDG--FICRCPPGFSGARCQS---SCGQVKCRKGEQCVHTASGPR 1365

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372
            C CP               P    + CA++PC HGGSC P    P++ C CA  ++G RC
Sbjct: 1366 CFCPS--------------PRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRC 1411

Query: 1373 EAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA-L 1431
            E   A P  +    C    C  K  D  CD  CNS  C WDGGDCSL++ +PW  C + L
Sbjct: 1412 ELYTAPPS-TPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPL 1470

Query: 1432 QCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTE 1491
             CW   NN +CD  C++  CL+DNF+C   G  +TC   Y+KYCADHF D  CDQGCN+E
Sbjct: 1471 PCWDYINN-QCDELCNTVECLFDNFECQ--GNSKTCK--YDKYCADHFKDNHCDQGCNSE 1525

Query: 1492 ECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHG 1551
            ECGWDGLDCA++ P  LA G LV+ VL+PPE+LL+ +  FL+ L  +L T+LR + D+ G
Sbjct: 1526 ECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQG 1585

Query: 1552 QAMVFPYHRPSPGSEPRARR-------ELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDA 1604
            + MV+PY+     +  + R        E   EV GS V LEIDNR C+Q  ++DHCF + 
Sbjct: 1586 ELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQ--DSDHCFKNT 1643

Query: 1605 QSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMV 1664
             +AA  L + +    L   YPL  V  E L P      LL LL    V++L I++LGV++
Sbjct: 1644 DAAAALLASHAIQGTLS--YPLVSVVSESLTPERTQ--LLYLLAVAVVIILFIILLGVIM 1699

Query: 1665 ARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATD---- 1720
            A+RKR+H +LW PEGF+L +D AS HK RREPVGQDA+G+KN++   S    + T     
Sbjct: 1700 AKRKRKHGSLWLPEGFTLRRD-ASNHK-RREPVGQDAVGLKNLSVQVSEANLIGTGTSEH 1757

Query: 1721 WMDTECPEAKRLKVEEPGMGAEE--AVDCRQWTQHHLVAADIRVAPAMALTPPQGDADAD 1778
            W+D E P+ K++K E+  + +EE   +D R WTQ HL AADIR  P++ALTPPQ + + D
Sbjct: 1758 WVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVD 1817

Query: 1779 GMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRT 1838
             +DVNVRGPDG TPLMLAS  GG+ + +  E+++A+D+SA+II+DL+ QGA L A+TDRT
Sbjct: 1818 VLDVNVRGPDGCTPLMLASLRGGSSD-LSDEDEDAEDSSANIITDLVYQGASLQAQTDRT 1876

Query: 1839 GETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTD 1898
            GE ALHLAARY+RADAAKRLLDAGAD NAQD+ GR PLH AV ADAQGVFQILIRNR TD
Sbjct: 1877 GEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTD 1936

Query: 1899 LDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLAL 1958
            LDARM DG+T LILAARLAVEGMV ELI   ADVNAVD+ GKSALHWAAAVNNVEATL L
Sbjct: 1937 LDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLL 1996

Query: 1959 LKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQ 2018
            LKNGAN+DMQD+KEETPLFLAAREGSYEAAK+LLDHFANR+ITDH+DRLPRDVA++R+H 
Sbjct: 1997 LKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHH 2056

Query: 2019 DIVRLLDQPSGPRSPPGP---HGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQ 2075
            DIVRLLD+ +   SPPG      L P++C P      LK    G KKSRRP  K+ +   
Sbjct: 2057 DIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMG-KKSRRPSAKSTMPTS 2115

Query: 2076 GP---------RGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPF-------------GG 2113
             P         +G  +K +L+    L++SSVTLSPVDSL+SP  +             G 
Sbjct: 2116 LPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGI 2175

Query: 2114 PPASPGGF--------PLEGPYAAATATAVSLAQLGGPGRAGLGR-----------QPPG 2154
              ASP           P+   +A + +    +  L       L              P  
Sbjct: 2176 LQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGS 2235

Query: 2155 GCVLSLGLLNPVAVPLDW--------------------------------ARLP------ 2176
            G   SL  L+PV VP DW                                +R P      
Sbjct: 2236 GSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHIT 2295

Query: 2177 -PPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVP-------------------- 2215
             P  P  P     L P   +  P     PQ   PP +A P                    
Sbjct: 2296 TPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPT 2355

Query: 2216 -------GHGEEYPAAGAHSSPPK-ARFLRVPSEHPYL-------TPS------------ 2248
                   G   +      H  P    ++   PS+H Y        TPS            
Sbjct: 2356 AMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYL 2415

Query: 2249 ---PESPEHWASPSPPSLSDWSESTPSP 2273
               PESP+ W+S SP S SDWS+ T SP
Sbjct: 2416 TPSPESPDQWSSSSPHSASDWSDVTTSP 2443


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 1173 bits (3034), Expect = 0.0
 Identities = 726/1981 (36%), Positives = 958/1981 (48%), Gaps = 241/1981 (12%)

Query: 278  CQLQPNACHNGGTCFN-TLGGHSCVCVNGWTGESCSQNIDDCATA-VCFHGATCHDRVAS 335
            C   P  C NGGTC + +LG  +C C  G+ GE+C Q  D C  A +C +G +C   + +
Sbjct: 28   CGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETC-QFPDPCQNAQLCQNGGSCQALLPA 86

Query: 336  FYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDEC 395
                 P+G             S+P         +P+    +CTC PGFTG  C   +++ 
Sbjct: 87   -----PLGLP-----------SSP---------SPLTPSFLCTCLPGFTGERCQAKLED- 120

Query: 396  SIGANPCEHLGRC-VNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFT 454
                + C   GRC +   G   C C  G+TG +C+   + C + PC N   CL    Q  
Sbjct: 121  PCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQ 179

Query: 455  CICMAGFTGTYCEVDIDEC--QSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECA 512
            C C  GF G  CE D++EC     PC  G  C + +  F C CP G  G  C+L    C 
Sbjct: 180  CHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCP 239

Query: 513  STPCRNGAKCVDQPDG----YECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFS 567
               C NG  C   P+     + C C  GF G  C+ N D+C    C +G  C DG+ +++
Sbjct: 240  PRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYT 299

Query: 568  CACAPGYTGTRCESQVDECRSQP---CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDC 624
            C C   +TG  C   VDEC +Q    CR+GG C +    + C C SG  G +CE N+DDC
Sbjct: 300  CLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC 359

Query: 625  ASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGE--NGFRC 681
             +  C  G  C D +  + C+C PG TG LC++E + C S PC     C          C
Sbjct: 360  IAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLC 418

Query: 682  LCPPGSLPPLCLPPSHPC-----AHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLAR 735
            LC PG   P C      C        PC HG  C + PG F C+C PG++G RC      
Sbjct: 419  LCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEAD--H 476

Query: 736  DACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLP 794
            + C SQPC  G TC      FHC CPPG++G+ CE+  + C   PC +   C        
Sbjct: 477  NECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQ 536

Query: 795  VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
             C C  G+ G RC++D+DEC   +PC   G C +  G+F C C  G+ GP C  ++++C 
Sbjct: 537  -CICLPGFSGTRCEEDIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECL 594

Query: 855  PNPCLNGGSCQDGVGSFSCSCLPGFAG-----PRCA-------------RDVDECLSNPC 896
             +PC  G SC D  G+F C C  GF G     P CA             +D   CL    
Sbjct: 595  SDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDG 654

Query: 897  GPG------TCT---DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFS 947
             PG       CT    H    +C C  G+ G  CE +L  C  + C +GGTC    + ++
Sbjct: 655  SPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYN 714

Query: 948  CLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ 1007
            C C  GYTG  C  E   C S PCL+GG C+ +  G+ CTC  S TGPQCQT  D+C   
Sbjct: 715  CTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSA 774

Query: 1008 PCQNGGRCV-QTGAY-CLCPPGWSGRLCDIR------SLPCREAAA-------------- 1045
            PC NGG CV + G + CLC  G+ G  C+ +        PCR  A               
Sbjct: 775  PCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPT 834

Query: 1046 ---------QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC-------- 1088
                      + +  ++ C     C+    S +C+C +G TG  C   +  C        
Sbjct: 835  GYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQG 894

Query: 1089 --LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLC 1146
              ++  C +GG C      Y C C PG+ G  C+D V+ C S+PCQ+G +C+   + YLC
Sbjct: 895  IDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLC 954

Query: 1147 SCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADI 1206
             C PG  G  C    D C   P       C ++GTC    GGF C CPPG+ GLRCE D+
Sbjct: 955  QCAPGYDGQNCSKELDACQSQP-------CHNHGTCTPKPGGFHCACPPGFVGLRCEGDV 1007

Query: 1207 NECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPG 1266
            +EC    CH   T  C       F C C  G +G  C+  + PC SQPC HGG C  + G
Sbjct: 1008 DECLDQPCHPTGTAAC-HSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAG 1066

Query: 1267 PGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRG---PRCACPPGLSGPS 1323
                L F CHC + F GP C   A SC    C  G  C  +P+    PRCAC  G  GP 
Sbjct: 1067 --SPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPD 1124

Query: 1324 CRSFPGSPPGASNASCAAAPCLHGGSCRPAPL--APFFRCACAQGWTGPRCEAPAAAPEV 1381
            C + P +P G    S    PCL+ GSC        P FRC+C     GPRC+ P A    
Sbjct: 1125 CLT-PPAPKGCGPPS----PCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAK--- 1176

Query: 1382 SEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA-LQCWRLFNNS 1440
                      C+ + GD  CD  C+ PG  WDGGDCSL V DPW+ C +  +CW LF + 
Sbjct: 1177 ---------GCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDG 1227

Query: 1441 RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC 1500
            +C P C S  CL+D +DC        C P Y++YC DHF +G C++GCNT ECGWDG DC
Sbjct: 1228 QCHPQCDSEECLFDGYDCET---PPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1284

Query: 1501 ASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560
              E         L L V+L P  L +      + LS  LR  L  R D  G+ MV+PY  
Sbjct: 1285 RPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPY-- 1342

Query: 1561 PSPGS----------EPRARRELAPEV-----------IGSVVMLEIDNRLCLQSPENDH 1599
              PG+          +P  +   AP+             G VV++ +D   C        
Sbjct: 1343 --PGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASR 1400

Query: 1600 CFPDAQSAADYLGALSAVERLD--FPYPLRDVRGEP-LEPPEPSVPLLPLL---VAGAVL 1653
            C  D      +L A++AV  L+   P PL  V       PP   +P  P+L   VAG +L
Sbjct: 1401 CPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPW-PVLCSPVAGVIL 1459

Query: 1654 L-LVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGES 1712
            L L  L++  ++ RR+REH  LW P GF+      S    RR P+G+D++G+K +     
Sbjct: 1460 LALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKP--- 1516

Query: 1713 LMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVD--CRQWTQHHLVAADIRVAPAMALTP 1770
               EV  D +   C   +  + EE G   E      C+ W+      A   +  A  LTP
Sbjct: 1517 -KAEVDEDGV-VMCSGPE--EGEEVGQAEETGPPSTCQLWSLSGGCGA---LPQAAMLTP 1569

Query: 1771 PQGDADADGMDVNVRGPDGFTPLMLASFCG----GALE------PMPTEEDEADDTSASI 1820
            PQ +++ +  D++ RGPDG TPLM A  CG    G  +      P P E           
Sbjct: 1570 PQ-ESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEP---------- 1618

Query: 1821 ISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAV 1880
               L+  GA   A T  TGET LHLAAR++R  AA+RLL+AGA+ N  D +GRTPLH AV
Sbjct: 1619 ---LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAV 1675

Query: 1881 TADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGK 1940
             ADA+ V Q+L+R+R T +DAR  DG+T L+LAARLAVE +VEELIA+ ADV A D+ GK
Sbjct: 1676 AADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGK 1735

Query: 1941 SALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREI 2000
            +ALHWAAAVNN  A  +LL+ GA+KD QD++E+TPLFLAAREG+ E A+LLL   A RE+
Sbjct: 1736 TALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAREL 1795

Query: 2001 TDHLDRLPRDVAQERLHQDIVRLLDQPSGP----RSPPGPHGLGPLLCPPGAFLPGLKAA 2056
             D     P DVA +R H D++ LL+    P    ++ PG    GP   P    +      
Sbjct: 1796 RDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREA-GPF--PRARTVSVSVPP 1852

Query: 2057 QSGSKKSRRPPGKAGLGPQGP----RGRGKKLTLACPGPLADSSV-TLSPVDSLDSPRPF 2111
              G    R     AG GP+G     + R   + LA  G  A S   +LS V +   P P 
Sbjct: 1853 HGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPR 1912

Query: 2112 G 2112
            G
Sbjct: 1913 G 1913



 Score =  968 bits (2502), Expect = 0.0
 Identities = 523/1301 (40%), Positives = 650/1301 (49%), Gaps = 130/1301 (9%)

Query: 42   PCLDGSPCANGGRCTQL-------PSREAA------CLCPPGWVGERCQ--LEDPCHSGP 86
            PC +   C NGG C  L       PS  +       C C PG+ GERCQ  LEDPC    
Sbjct: 67   PCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSF 126

Query: 87   CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSC 146
            C+ RG C    +  + R  C C  G+ G  C L D C ++PC +G  C +    +  C C
Sbjct: 127  CSKRGRCH---IQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVC-LATYPQIQCHC 182

Query: 147  PPGYQGRSCRSDVDEC-RVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSP 205
            PPG++G +C  DV+EC +   PC  G +C NT GSF+C CP G  GP CE  A PC P  
Sbjct: 183  PPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG 242

Query: 206  CRNGGTCR--QSGDLTYD-CACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262
            C NGGTC+     D T+  C C PGF G +CEVN D+C  H+C NGGTC DG++TY C C
Sbjct: 243  CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLC 302

Query: 263  PPEWTGQFCTEDVDECQLQ-PNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATA 321
            P  WTG  C+EDVDEC+ Q P  C NGGTC N+ G   CVCV+GW G SC +N+DDC  A
Sbjct: 303  PETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAA 362

Query: 322  VCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPP 381
             C  G+TC DRV SF C CP G+TGLLCHL+D C+S PCH DA C TNP+ G  +C C P
Sbjct: 363  TCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQP 422

Query: 382  GFTGGACDQDVDECSI---GANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG 438
            G++G  C QD+DEC +   G +PCEH G C+NT GSF C C  GYTG RCE D NECLS 
Sbjct: 423  GYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQ 482

Query: 439  PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498
            PC   +TCLD +  F C+C  G  G  CEV+ +EC S+PC+N   C D +NGF C C  G
Sbjct: 483  PCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPG 542

Query: 499  FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHG- 557
            FSG+ C+ D+DEC S+PC NG +C DQP  + C+C  GFEG  C   VD+C  DPC  G 
Sbjct: 543  FSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGA 602

Query: 558  RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNC 617
             C+D   +F C C  G+TG  CE  V  C    C+    C D  DK  C CP G+ G  C
Sbjct: 603  SCLDLPGAFFCLCPSGFTGQLCE--VPLCAPNLCQPKQICKDQKDKANCLCPDGSPG--C 658

Query: 618  EVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGEN 677
                D+C    C  G C+    R  CVC  G+TGP C  E+  C S+PC  GG+C    +
Sbjct: 659  APPEDNCT---CHHGHCQ----RSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPS 711

Query: 678  GFRCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLARD 736
            G+ C CP G   P C      C   PC + G C  +PGG+ C C P  +GP+C  S   D
Sbjct: 712  GYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTS--TD 769

Query: 737  ACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE--LLSPCTPNPCEHGGRCESAPGQLP 794
             C S PC  GGTC +    F C C  G QG +CE  L   C  +PC +   C+ +P Q P
Sbjct: 770  YCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSP-QGP 828

Query: 795  VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
             C CP G+ G  CQ  +D CA   PC  +  C     SF C C  G+TGP C+  ++ C 
Sbjct: 829  RCLCPTGYTGGSCQTLMDLCA-QKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQ 887

Query: 855  ----------PNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTD 903
                       + C NGG C D   S+ C C PGF G  C   V+ C S PC  G TC  
Sbjct: 888  KAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMA 947

Query: 904  HVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEA 963
              + + C C PGY G +C ++L  C    C N GTC      F C C PG+ G  C+ + 
Sbjct: 948  QPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDV 1007

Query: 964  DPCLSRPCLHGG--VCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--- 1018
            D CL +PC   G   C +    F C CL   TG  C+  +D C  QPC +GG C  T   
Sbjct: 1008 DECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGS 1067

Query: 1019 --GAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY---CVCP 1073
              G  C CP G+ G  C  R+  C              C  GG C+      +   C C 
Sbjct: 1068 PLGFICHCPKGFEGPTCSHRAPSCG----------FHHCHHGGLCLPSPKPGFPPRCACL 1117

Query: 1074 EGRTGSHCEQEVDP--C-LAQPCQHGGTCRGYMG----GYMCECLPGYNGDNCEDDVDEC 1126
             G  G  C     P  C    PC + G+C    G    G+ C C     G  C+    + 
Sbjct: 1118 SGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ----KP 1173

Query: 1127 ASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV 1186
             ++ C+  G   D      CS P G        +  DC  G P D    C  +  C  L 
Sbjct: 1174 GAKGCE--GRSGDGACDAGCSGPGGNW------DGGDCSLGVP-DPWKGCPSHSRCWLL- 1223

Query: 1187 GGFR-CTCPPGYTGLRCEADINECRS-GACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244
              FR   C P      C  D  +C +  AC  A+ +             CH  F    C+
Sbjct: 1224 --FRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQ------------YCHDHFHNGHCE 1269

Query: 1245 TVLSPCESQPC-QHGGQCRPSPGPGGGLTFTCHCAQPFWGP 1284
                 C +  C   GG CRP  G             P WGP
Sbjct: 1270 ---KGCNTAECGWDGGDCRPEDG------------DPEWGP 1295


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  530 bits (1366), Expect = e-150
 Identities = 321/1060 (30%), Positives = 462/1060 (43%), Gaps = 169/1060 (15%)

Query: 49   CANGGRC-TQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTAR-FSC 106
            C+  G+C ++  S+  +C C P + G+ CQ  D C   PC   G C +       + + C
Sbjct: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242

Query: 107  RCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDEC--- 162
             C   F G +CS +   C    C HG  CS      F+C C   + G  C      C   
Sbjct: 243  VCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301

Query: 163  -------------------------RVGE---------PCRHGGTCLNTPGSFRCQCPAG 188
                                     + GE         PC++G  C+       C C   
Sbjct: 302  LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361

Query: 189  YTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP--GHRCL 246
            +T  LC++    C   P RN  TC++  +  Y C+C+ GF  +NCE  +D C      CL
Sbjct: 362  FTDLLCKSIQTSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420

Query: 247  NGG-----------TCVDG--------------VNTYNCQC------------PPE---- 265
            N              C+ G              ++ + C C            P +    
Sbjct: 421  NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480

Query: 266  WTGQFCTEDVDECQ--------LQPNACH----------NGGTCFNTLGGHSCVCVNG-- 305
            W   F   + ++CQ        L  N             N  +C+    G   +C NG  
Sbjct: 481  WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540

Query: 306  -----------------WTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLL 348
                             W G    +N  D     C H A C D +    C+C +   G L
Sbjct: 541  CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRL 600

Query: 349  CHLD-DACVSN---PCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEH 404
            C ++ D C+ N     H   +  ++  N    C+    +    C+ D ++C   +  C++
Sbjct: 601  CVVNVDYCLGNHSISVHGLCLALSHNCN----CSGLQRYERNICEIDTEDCKSAS--CKN 654

Query: 405  LGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQ------------ 452
                 + +G F  +C  G+ G +CE D++EC S PC+N ATC+D+ G             
Sbjct: 655  GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVV 714

Query: 453  --FTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE 510
              F+C+C  G+ G  CE DID+C  + C +   CKD    + C C S + G+ C+ + +E
Sbjct: 715  DGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNE 774

Query: 511  CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR-CVDGI--ASFS 567
            C   PC+N + C D    Y C C  G+ G  C   +++C  DPC +G  C +      F 
Sbjct: 775  CKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFV 834

Query: 568  CACAPGYTGTRCESQVDECR--SQPCRHGGKCLDLVD-KYLCRCPSGTTGVNCEVNIDDC 624
            C C P YTG  C  + + C     PCR+   CL LVD    C C     G NCE+++ DC
Sbjct: 835  CLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDC 894

Query: 625  ASNPCT-FGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLC 683
                C  +G C D +N + C+C+PGF+G LC +EINEC+S PC   G+CVD  N F C C
Sbjct: 895  LFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNC 954

Query: 684  PPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQP 742
             P    P C    + C   PC     C     G+ C+C PG++G  C  +L  D C S+P
Sbjct: 955  EPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINL--DECLSEP 1012

Query: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQG 801
            C   G C      + C C  G  G  CE   + C  NPC HG RC     + P CSC   
Sbjct: 1013 CLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEYP-CSCDAD 1070

Query: 802  WQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC-DPNP--- 857
                +C+  +++C    PC   G C   A  F+C C  GYTG  C++ I++C +P     
Sbjct: 1071 GTSTQCKIKINDCTS-IPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSV 1129

Query: 858  -CLNGGSCQDGVG-SFSCSCLPGFAGPRCARDVDECLSNPCGPGT-CTDHVASFTCTCPP 914
             CLNGG C DG G +F C CLPGF+G  C  +++EC S+PC  G  C DH+  + C C P
Sbjct: 1130 ICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQP 1189

Query: 915  GYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY 954
            G+ G HCE +L +C P+SC +   C++     +CLC PG+
Sbjct: 1190 GWSGHHCENEL-ECIPNSCVHE-LCMENEPGSTCLCTPGF 1227



 Score =  517 bits (1332), Expect = e-146
 Identities = 342/1097 (31%), Positives = 465/1097 (42%), Gaps = 169/1097 (15%)

Query: 240  CPGHRCLNGGTCVDGV--NTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGG 297
            C GH     G C+      TY+C C P ++G++C E +D C  +P  C N G+C N    
Sbjct: 183  CSGH-----GKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKP--CKNNGSCINKREN 234

Query: 298  -----HSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD 352
                 + CVC   +TG++CS+ I  C   VCFHG   +    SF C C    +G  C + 
Sbjct: 235  WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294

Query: 353  -DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT 411
               CVS    +  IC  +  +      CP G +    + DV E S+   PC++   C+  
Sbjct: 295  AKPCVSLLFWKRGICPNS--SSAYTYECPKGSSSQNGETDVSEFSLV--PCQNGTDCIKI 350

Query: 412  QGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDID 471
                +C C   +T   C++    C S P RN ATC      + C C++GFT   CE  ID
Sbjct: 351  SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410

Query: 472  E----------------------------CQSSPC------------------VNGGVCK 485
                                         C  +PC                     G+C+
Sbjct: 411  HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470

Query: 486  DRVNG-FSCTCPSGFSGST---CQLDVD------------------------------EC 511
            D+    F      GF+GS    CQ  +D                              E 
Sbjct: 471  DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG 530

Query: 512  ASTPCRNGAKCVDQPDGYECR--CAEGFEGTLCDRNVDDCSPDPCHHGR-CVDGIASFSC 568
                C NG  C+ + D  E R  C   + G +   N  D   + C H   C D I    C
Sbjct: 531  TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRC 590

Query: 569  ACAPGYTGTRCESQVDECR-SQPCRHGGKCLDLVDKYLCRCPSGTTGVN---CEVNIDDC 624
            +C+  Y G  C   VD C  +      G CL L   + C C SG        CE++ +DC
Sbjct: 591  SCSLSYIGRLCVVNVDYCLGNHSISVHGLCLAL--SHNCNC-SGLQRYERNICEIDTEDC 647

Query: 625  ASNPCTFGVCRDGINRYDC-VCQPGFTGPLCNVEINECASSPCGEGGSCVDGE------- 676
             S  C  G     +  Y    C PGF G  C ++I+ECAS PC  G +C+D         
Sbjct: 648  KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQC 707

Query: 677  -------NGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPR 728
                   +GF CLC PG +   C      C    C H   C D    ++CVC   W G  
Sbjct: 708  VPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNF 767

Query: 729  CSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC-ELLSPCTPNPCEHGGRCE 787
            C Q    + C+  PC+   TC+     + C C  G  G+ C E ++ C  +PC +GG C 
Sbjct: 768  CEQE--SNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCH 825

Query: 788  SA--PGQLPVCSCPQGWQGPRCQQDVDEC-AGPAPCGPHGICTNLAGSFS-CTCHGGYTG 843
             +  PGQ  VC CP  + G  C Q  + C     PC  +  C  L  +   C C   + G
Sbjct: 826  ESTIPGQF-VCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG 884

Query: 844  PSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCT 902
             +C+ D+ DC    C + G C+D V +F C C PGF+G  C  +++EC S PC   GTC 
Sbjct: 885  KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCV 944

Query: 903  DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962
            D    F C C P Y G  CE D+  C  S C +   CV   + ++CLC PGYTG +C+  
Sbjct: 945  DLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEIN 1004

Query: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT-GAY 1021
             D CLS PCLH GVC      + C C   F G  C+T  + C   PC +G RC +    Y
Sbjct: 1005 LDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEY 1063

Query: 1022 -CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH 1080
             C C    +   C I+   C              C   G C        C+CP G TG++
Sbjct: 1064 PCSCDADGTSTQCKIKINDCTSIP----------CMNEGFCQKSAHGFTCICPRGYTGAY 1113

Query: 1081 CEQEVDPCLAQP------CQHGGTCRGYMGG-YMCECLPGYNGDNCEDDVDECASQPCQH 1133
            CE+ +D C A+P      C +GG C    G  + C CLPG++G  CE +++EC+S PC H
Sbjct: 1114 CEKSIDNC-AEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLH 1172

Query: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
            G  C D +  Y+C C PG  G  CE NE +C P         C+H   C++   G  C C
Sbjct: 1173 GADCEDHINGYVCKCQPGWSGHHCE-NELECIPNS-------CVHE-LCMENEPGSTCLC 1223

Query: 1194 PPGY----TGLRCEADI 1206
             PG+     GL C  +I
Sbjct: 1224 TPGFMTCSIGLLCGDEI 1240



 Score =  471 bits (1213), Expect = e-132
 Identities = 308/1057 (29%), Positives = 428/1057 (40%), Gaps = 189/1057 (17%)

Query: 471  DECQSSPCVNGGVCKDRV--NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG 528
            +   S  C   G C        +SC C   FSG  CQ ++D C+  PC+N   C+++ + 
Sbjct: 176  ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKREN 234

Query: 529  -----YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIA-SFSCACAPGYTGTRCESQ 582
                 YEC C   F G  C   +  C P  C HG C +  + SF C C   ++G  CE  
Sbjct: 235  WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294

Query: 583  VDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRY 641
               C S      G C +    Y   CP G++  N E ++ + +  PC  G  C    N  
Sbjct: 295  AKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDV 354

Query: 642  DCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPP----------- 690
             C+C P FT  LC      C S P     +C   E  + C C  G               
Sbjct: 355  MCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKL 414

Query: 691  --------------------LCLPPSHPCAHEPC-------------------SHGICYD 711
                                +C+P    C   PC                    HGIC D
Sbjct: 415  LSINCLNEEWCFNIIGRFKYVCIPG---CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQD 471

Query: 712  -APGGFRCVCEPGWSGPRCSQS---------LARDACES--------------------- 740
              P  F  V + G++G    +          LA +  E                      
Sbjct: 472  KGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGT 531

Query: 741  -QPCRAGGTCSS--DGMGFHCTCPPGVQGRQ-CELLSPCTPNPCEHGGRCESAPGQLPVC 796
             + C  G +C S  D   +   C     G    E  +    N C+H   C+    + P C
Sbjct: 532  KEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINR-PRC 590

Query: 797  SCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHG--GYTGPSCDQDINDCD 854
            SC   + G  C  +VD C G      HG+C  LA S +C C G   Y    C+ D  DC 
Sbjct: 591  SCSLSYIGRLCVVNVDYCLGNHSISVHGLC--LALSHNCNCSGLQRYERNICEIDTEDCK 648

Query: 855  PNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDH--------- 904
               C NG +     G F   C+PGF G +C  D+DEC S+PC  G TC D          
Sbjct: 649  SASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCV 708

Query: 905  -----VASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHC 959
                 V  F+C C PGY G  CEQD+ DC  ++C +  TC D   S+ C+C   + G  C
Sbjct: 709  PPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFC 768

Query: 960  QHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT- 1018
            + E++ C   PC +   C+  +  +RC C   +TG  C   ++ C   PC NGG C ++ 
Sbjct: 769  EQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHEST 828

Query: 1019 --GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD-EDSSHYCVCPE 1074
              G + CLCPP ++G+ C  R   C          L   C+    C+   D++ +C+C E
Sbjct: 829  IPGQFVCLCPPLYTGQFCHQRYNLCD--------LLHNPCRNNSTCLALVDANQHCICRE 880

Query: 1075 GRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHG 1134
               G +CE +V  CL   CQ  G C   +  + C C PG++G  CE +++EC+S+PC++ 
Sbjct: 881  EFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNN 940

Query: 1135 GSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCP 1194
            G+C+DL  R+ C+C P   G  CE++ + C   P       CL    CV    G+ C C 
Sbjct: 941  GTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP-------CLDEENCVYRTDGYNCLCA 993

Query: 1195 PGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQP 1254
            PGYTG+ CE +++EC S  C   H   C+ D    + C C +GF G  C+T  + C S P
Sbjct: 994  PGYTGINCEINLDECLSEPC--LHDGVCI-DGINHYTCDCKSGFFGTHCETNANDCLSNP 1050

Query: 1255 CQHG--------------------------GQCRPSPGPGGGLT------FTCHCAQPFW 1282
            C HG                            C   P    G        FTC C + + 
Sbjct: 1051 CLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYT 1110

Query: 1283 GPRCERVARSCRELQ-----CPVGVPCQQTPRGP-RCACPPGLSGPSCRSFPGSPPGASN 1336
            G  CE+   +C E +     C  G  C   P     C C PG SG  C          + 
Sbjct: 1111 GAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE--------INI 1162

Query: 1337 ASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
              C+++PCLHG  C        + C C  GW+G  CE
Sbjct: 1163 NECSSSPCLHGADCEDHING--YVCKCQPGWSGHHCE 1197



 Score =  471 bits (1211), Expect = e-132
 Identities = 248/725 (34%), Positives = 361/725 (49%), Gaps = 49/725 (6%)

Query: 49   CANGGRC-TQLPSREAACLCPPGWVGERCQLEDPC--HSGPCAGRGVCQSSVVAGTARFS 105
            CANG  C ++  S+E   LC   W G    LE+        C    VC+  +     R  
Sbjct: 535  CANGCSCLSEEDSQEYRYLCFLRWAGNM-YLENTTDDQENECQHEAVCKDEI----NRPR 589

Query: 106  CRCPRGFRGPDCSLP-DPCLS--SPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDEC 162
            C C   + G  C +  D CL   S   HG   ++  +    CS    Y+   C  D ++C
Sbjct: 590  CSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCN--CSGLQRYERNICEIDTEDC 647

Query: 163  RVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC-RQSGDLT-- 219
            +    C++G T  +  G F  +C  G+ G  CE     CA  PC+NG TC  Q G+    
Sbjct: 648  KSAS-CKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQ 706

Query: 220  ----------YDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQ 269
                      + C C PG+ G  CE ++DDC  + C +  TC D   +Y C C  +W G 
Sbjct: 707  CVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGN 766

Query: 270  FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATC 329
            FC ++ +EC++ P  C N  TC +    + C C +GWTG++CS+ I++C +  C +G  C
Sbjct: 767  FCEQESNECKMNP--CKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLC 824

Query: 330  HDRV--ASFYCACPMGKTGLLCHLD-DAC--VSNPCHEDAICDTNPVNGRAICTCPPGFT 384
            H+      F C CP   TG  CH   + C  + NPC  ++ C    V+    C C   F 
Sbjct: 825  HESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTC-LALVDANQHCICREEFE 883

Query: 385  GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQA 444
            G  C+ DV +C   +  C+  G C +   +F C C  G++G  CE ++NEC S PC+N  
Sbjct: 884  GKNCEIDVKDCLFLS--CQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNG 941

Query: 445  TCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTC 504
            TC+D   +F C C   + G +CE+D+++C+ SPC++   C  R +G++C C  G++G  C
Sbjct: 942  TCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINC 1001

Query: 505  QLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIA 564
            ++++DEC S PC +   C+D  + Y C C  GF GT C+ N +DC  +PC HGRC + I 
Sbjct: 1002 EINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELIN 1061

Query: 565  SFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDC 624
             + C+C    T T+C+ ++++C S PC + G C      + C CP G TG  CE +ID+C
Sbjct: 1062 EYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNC 1121

Query: 625  ASNPCTF------GVCRDGI-NRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGEN 677
            A            G+C DG  + +DC C PGF+G  C + INEC+SSPC  G  C D  N
Sbjct: 1122 AEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHIN 1181

Query: 678  GFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWS----GPRCSQSL 733
            G+ C C PG     C      C    C H +C +   G  C+C PG+     G  C   +
Sbjct: 1182 GYVCKCQPGWSGHHC-ENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEI 1240

Query: 734  ARDAC 738
             R  C
Sbjct: 1241 RRITC 1245



 Score =  368 bits (945), Expect = e-101
 Identities = 194/588 (32%), Positives = 280/588 (47%), Gaps = 54/588 (9%)

Query: 48   PCANGGRCTQLPSR-------------EAACLCPPGWVGERCQLE-DPCHSGPCAGRGVC 93
            PC NG  C   P                 +CLC PG+VG RC+ + D C    C     C
Sbjct: 689  PCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTC 748

Query: 94   QSSVVAGTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQG 152
            +   ++    + C C   + G  C    + C  +PC + + C+      + C C  G+ G
Sbjct: 749  KDLHLS----YQCVCLSDWEGNFCEQESNECKMNPCKNNSTCT-DLYKSYRCECTSGWTG 803

Query: 153  RSCRSDVDECRVGEPCRHGGTCLNT--PGSFRCQCPAGYTGPLCENPAVPC--APSPCRN 208
            ++C  +++EC   +PC +GG C  +  PG F C CP  YTG  C      C    +PCRN
Sbjct: 804  QNCSEEINECD-SDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRN 862

Query: 209  GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
              TC    D    C C   FEG+NCE++V DC    C + G C D VN + C C P ++G
Sbjct: 863  NSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSG 922

Query: 269  QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT 328
              C  +++EC  +P  C N GTC +      C C   + G  C  +++ C  + C     
Sbjct: 923  SLCEIEINECSSEP--CKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEEN 980

Query: 329  CHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGA 387
            C  R   + C C  G TG+ C ++ D C+S PC  D +C  + +N    C C  GF G  
Sbjct: 981  CVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVC-IDGIN-HYTCDCKSGFFGTH 1038

Query: 388  CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447
            C+ + ++C   +NPC H GRC      + C C    T  +C+  +N+C S PC N+  C 
Sbjct: 1039 CETNANDCL--SNPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQ 1095

Query: 448  DRIGQFTCICMAGFTGTYCEVDIDEC-----QSSPCVNGGVCKDRV-NGFSCTCPSGFSG 501
                 FTCIC  G+TG YCE  ID C      S  C+NGG+C D   + F C C  GFSG
Sbjct: 1096 KSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSG 1155

Query: 502  STCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVD 561
              C+++++EC+S+PC +GA C D  +GY C+C  G+ G  C+  + +C P+ C H  C++
Sbjct: 1156 QFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-ECIPNSCVHELCME 1214

Query: 562  GIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCP 609
                 +C C PG+                C  G  C D + +  C  P
Sbjct: 1215 NEPGSTCLCTPGF--------------MTCSIGLLCGDEIRRITCLTP 1248



 Score =  267 bits (682), Expect = 1e-70
 Identities = 233/943 (24%), Positives = 325/943 (34%), Gaps = 226/943 (23%)

Query: 702  EPCS-HGICYDAPGG--FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSS-----DG 753
            E CS HG C        + C C+P +SG  C +    DAC  +PC+  G+C +     D 
Sbjct: 181  EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL---DACSFKPCKNNGSCINKRENWDE 237

Query: 754  MGFHCTCPPGVQGRQC-ELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD 812
              + C C P   G+ C E++  C P+ C HG  C +      +C C + + GP C+    
Sbjct: 238  QAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN-CSNITSNSFICECDEQFSGPFCEVSAK 296

Query: 813  ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-------- 864
             C         GIC N + +++  C  G +  + + D+++    PC NG  C        
Sbjct: 297  PCVSLL-FWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVM 355

Query: 865  ---------------QDGVGSFS---------------CSCLPGFAGPRCARDVDE---- 890
                           Q    SF                CSC+ GF    C + +D     
Sbjct: 356  CICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLL 415

Query: 891  ------------------------CLSNPCG-------------------PGTCTDH-VA 906
                                    C  NPC                     G C D   A
Sbjct: 416  SINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPA 475

Query: 907  SFTCTCPPGYGGF-----------------HCEQDL-----PDCSPSSCF---------- 934
             F      G+ G                  +C +D      P+ + SSC+          
Sbjct: 476  QFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEIC 535

Query: 935  -NGGTCVDGVNS--FSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLES 991
             NG +C+   +S  +  LC   + G              C H  VC       RC+C  S
Sbjct: 536  ANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLS 595

Query: 992  FTGPQCQTLVDWC-SRQPCQNGGRCVQTGAYCLCP--PGWSGRLCDIRSLPCREAAAQIG 1048
            + G  C   VD+C         G C+     C C     +   +C+I +  C+ A+    
Sbjct: 596  YIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSAS---- 651

Query: 1049 VRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMC 1108
                  C+ G          +  C  G  G+ CE ++D C + PC++G TC    G Y C
Sbjct: 652  ------CKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFC 705

Query: 1109 ECLP--------------GYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLG 1154
            +C+P              GY G  CE D+D+C    C+H  +C DL   Y C C     G
Sbjct: 706  QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEG 765

Query: 1155 VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRS--- 1211
              CE   ++C   P       C +N TC DL   +RC C  G+TG  C  +INEC S   
Sbjct: 766  NFCEQESNECKMNP-------CKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPC 818

Query: 1212 ---GACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCE--SQPCQHGGQCRPSPG 1266
               G CH +          G F CLC   ++G  C    + C+    PC++   C     
Sbjct: 819  MNGGLCHESTIP-------GQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVD 871

Query: 1267 PGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR- 1325
                    C C + F G  CE   + C  L C     C+      RC C PG SG  C  
Sbjct: 872  ANQH----CICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEI 927

Query: 1326 --SFPGSPPGASNASCAAAPCLHGGSCRPAPLAPF------------------------- 1358
              +   S P  +N +C         +C P    PF                         
Sbjct: 928  EINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDG 987

Query: 1359 FRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCS 1418
            + C CA G+TG  CE      E   EP      C        CD  C S   G+ G  C 
Sbjct: 988  YNCLCAPGYTGINCE--INLDECLSEPCLHDGVCIDGINHYTCD--CKS---GFFGTHCE 1040

Query: 1419 LSVGDPW-RQCEALQCWRLFNN--SRCDPACSSPACLYDNFDC 1458
             +  D     C   +C  L N     CD   +S  C     DC
Sbjct: 1041 TNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDC 1083



 Score =  260 bits (664), Expect = 1e-68
 Identities = 150/466 (32%), Positives = 209/466 (44%), Gaps = 45/466 (9%)

Query: 45   DGSPCANGGRC--TQLPSREAACLCPPGWVGERC----QLEDPCHSGPCAGRGVCQSSVV 98
            D  PC NGG C  + +P  +  CLCPP + G+ C     L D  H+ PC     C + V 
Sbjct: 814  DSDPCMNGGLCHESTIPG-QFVCLCPPLYTGQFCHQRYNLCDLLHN-PCRNNSTCLALV- 870

Query: 99   AGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS 157
               A   C C   F G +C +    CL   C     C       F C C PG+ G  C  
Sbjct: 871  --DANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCE-DMVNNFRCICRPGFSGSLCEI 927

Query: 158  DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD 217
            +++EC   EPC++ GTC++    F C C   Y GP CE     C  SPC +   C    D
Sbjct: 928  EINECS-SEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD 986

Query: 218  LTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDE 277
              Y+C C PG+ G NCE+N+D+C    CL+ G C+DG+N Y C C   + G  C  + ++
Sbjct: 987  -GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNAND 1045

Query: 278  CQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFY 337
            C   P   H  G C   +  + C C    T   C   I+DC +  C +   C      F 
Sbjct: 1046 CLSNP-CLH--GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFT 1102

Query: 338  CACPMGKTGLLCHLD-DACV-----SNPCHEDAICDTNPVNGRAI-CTCPPGFTGGACDQ 390
            C CP G TG  C    D C      S  C    IC   P  G    C C PGF+G  C+ 
Sbjct: 1103 CICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGP--GHTFDCRCLPGFSGQFCEI 1160

Query: 391  DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450
            +++ECS  ++PC H   C +    ++C+C  G++G  CE ++ EC+   C ++  C++  
Sbjct: 1161 NINECS--SSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-ECIPNSCVHE-LCMENE 1216

Query: 451  GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCP 496
               TC+C  GF                C  G +C D +   +C  P
Sbjct: 1217 PGSTCLCTPGF--------------MTCSIGLLCGDEIRRITCLTP 1248



 Score =  210 bits (535), Expect = 1e-53
 Identities = 189/785 (24%), Positives = 269/785 (34%), Gaps = 157/785 (20%)

Query: 808  QQDVDECAGPAPCGPHGICTNLAGS--FSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQ 865
            QQ   E      C  HG C + A S  +SC C   ++G  C Q+++ C   PC N GSC 
Sbjct: 171  QQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCI 229

Query: 866  D-----GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVA-SFTCTCPPGYGGF 919
            +        ++ C C P F G  C+  + +C  + C  G C++  + SF C C   + G 
Sbjct: 230  NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289

Query: 920  HCEQDLPDC----------SPSS----------------------------CFNGGTCVD 941
             CE     C           P+S                            C NG  C+ 
Sbjct: 290  FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349

Query: 942  GVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLV 1001
              N   C+C P +T   C+     C S P  +   C      + C+C+  FT   C+  +
Sbjct: 350  ISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409

Query: 1002 DWCSRQP--CQNGGRCVQ-TGAY-CLCPPGWSGRLCDI--RSLPCREAAAQIGVRLEQLC 1055
            D C      C N   C    G +  +C PG +   C          +     GV    +C
Sbjct: 410  DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGIC 469

Query: 1056 QAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDP--CLAQPC-------------------Q 1094
            Q  G    E    + +   G  G  C+  +D    LA  C                    
Sbjct: 470  QDKGPAQFE--YVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP 527

Query: 1095 HGGTCRGYMGGYMC-----------ECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR 1143
            H GT      G  C            C   + G+   ++  +     CQH   C D + R
Sbjct: 528  HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINR 587

Query: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCL---HNGTC------------------ 1182
              CSC    +G LC +N D C     +     CL   HN  C                  
Sbjct: 588  PRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDC 647

Query: 1183 -----------VDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG--- 1228
                         L G F   C PG+ G +CE DI+EC S  C    T  C+  PG    
Sbjct: 648  KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGAT--CIDQPGNYFC 705

Query: 1229 ----------GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCA 1278
                      GF CLC+ G+ G RC+  +  C    C+H   C+        L++ C C 
Sbjct: 706  QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDL-----HLSYQCVCL 760

Query: 1279 QPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNAS 1338
              + G  CE+ +  C+   C     C    +  RC C  G +G +C              
Sbjct: 761  SDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC--------SEEINE 812

Query: 1339 CAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGD 1398
            C + PC++GG C  + +   F C C   +TG  C       ++   P    + C A    
Sbjct: 813  CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDA 872

Query: 1399 QR---CDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSR--CDPACSSPACLY 1453
             +   C  E     C  D  DC       +  CE      + NN R  C P  S   C  
Sbjct: 873  NQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCE-----DMVNNFRCICRPGFSGSLCEI 927

Query: 1454 DNFDC 1458
            +  +C
Sbjct: 928  EINEC 932



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 30/83 (36%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 234  EVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQ---PNACHNGGT 290
            + +   C   +C NGGTC++   +  C C   W G FCTE V  C  +   P+ C  G T
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667

Query: 291  CFNTLGGHSCVCVNGWTGESCSQ 313
            C +   G++C C  G TG  C Q
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 32/81 (39%), Positives = 40/81 (49%), Gaps = 6/81 (7%)

Query: 198  AVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC-----PGHRCLNGGTCV 252
            A PC+   C NGGTC +SG   Y C C  G++G  C   V  C     P H C  G TC+
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669

Query: 253  DGVNTYNCQCPPEWTGQFCTE 273
               + Y C CP   TG +C +
Sbjct: 2670 SLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 31/89 (34%), Positives = 38/89 (42%), Gaps = 7/89 (7%)

Query: 1075 GRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQ----- 1129
            GR+   C     PC    C +GGTC        C C  G+ G  C + V  C  +     
Sbjct: 2603 GRSVGQCH--ASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH 2660

Query: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
             C  G +CI L   Y C CP GT G+ CE
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 29/75 (38%), Positives = 34/75 (45%), Gaps = 1/75 (1%)

Query: 738  CESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCS 797
            C    CR  GTC SD     C CP    G+ C+  S C  NPC +G  C    G   VC 
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS-CENNPCGNGATCVPKSGTDIVCL 2397

Query: 798  CPQGWQGPRCQQDVD 812
            CP G  GP C   ++
Sbjct: 2398 CPYGRSGPLCTDAIN 2412



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 7/112 (6%)

Query: 40   APPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVV 98
            A P L+   C NGG C   P     C C PG+ G+ C++  + C S PC     C+  + 
Sbjct: 1122 AEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHIN 1181

Query: 99   AGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGY 150
                 + C+C  G+ G  C     C+ + C H   C     G   C C PG+
Sbjct: 1182 G----YVCKCQPGWSGHHCENELECIPNSCVH-ELCMENEPGS-TCLCTPGF 1227



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 2/98 (2%)

Query: 371  VNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCET 430
            +N + +     G  GG+   D D  + G N C + G C     +F C+C   + G  C  
Sbjct: 2853 INNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQ 2912

Query: 431  DVNECLSGPCRNQATCL-DRIGQFTCICMAGFTGTYCE 467
             V+ CL+  C +Q+ C+ D+   ++C+C  G+ G YCE
Sbjct: 2913 SVS-CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 5/79 (6%)

Query: 194  CENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCV- 252
            C+  A  C  + CRNGG C  +G  T+ C CLP + G  C  +V  C  + CL+   C+ 
Sbjct: 2874 CDGTA--CGYNTCRNGGECTVNGT-TFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIP 2929

Query: 253  DGVNTYNCQCPPEWTGQFC 271
            D   +Y+C C   W G++C
Sbjct: 2930 DQSFSYSCLCTLGWVGRYC 2948



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 11/86 (12%)

Query: 544  RNVDDCSPDPC------HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQP-----CR 592
            R+V  C   PC      + G C++   S  C C  G+ G+ C   V  C  +      C 
Sbjct: 2604 RSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCS 2663

Query: 593  HGGKCLDLVDKYLCRCPSGTTGVNCE 618
             G  C+ L   Y C CP GTTG+ CE
Sbjct: 2664 RGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 28/83 (33%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 275  VDECQLQPNA---CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDC-----ATAVCFHG 326
            V +C   P +   C NGGTC  +     C C  GW G  C++ +  C         C  G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 327  ATCHDRVASFYCACPMGKTGLLC 349
            ATC      + C CP+G TG+ C
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 30/91 (32%), Positives = 39/91 (42%), Gaps = 7/91 (7%)

Query: 1118 NCEDDVDECASQPCQ-----HGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDS 1172
            N    V +C + PC      +GG+CI+      C+C  G  G  C      C P    D 
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEH--DP 2658

Query: 1173 GPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
               C    TC+ L  G+ C CP G TG+ CE
Sbjct: 2659 PHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 29/92 (31%), Positives = 39/92 (42%), Gaps = 10/92 (10%)

Query: 470  IDECQSSPCV-----NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC-----ASTPCRNG 519
            + +C +SPC      NGG C +      C C +G+ GS C   V  C         C  G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 520  AKCVDQPDGYECRCAEGFEGTLCDRNVDDCSP 551
            A C+  P GY C C  G  G  C++ +    P
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQALSISDP 2697



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 28/82 (34%), Positives = 34/82 (41%), Gaps = 7/82 (8%)

Query: 1004 CSRQPCQNGGRCVQTGA--YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061
            CS   C NGG C+++G   YC C  GW G  C      C              C  G  C
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDP-----PHHCSRGATC 2668

Query: 1062 VDEDSSHYCVCPEGRTGSHCEQ 1083
            +     + C CP G TG +CEQ
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 28/82 (34%), Positives = 38/82 (46%), Gaps = 9/82 (10%)

Query: 236  NVDDCPG-----HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGT 290
            NV DC G     + C NGG C     T++C+C P+W G  C + V       N C +   
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV---SCLNNLCLHQSL 2926

Query: 291  CF-NTLGGHSCVCVNGWTGESC 311
            C  +    +SC+C  GW G  C
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYC 2948



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 6/93 (6%)

Query: 768  QCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAG----PAPCGPH 823
            QC   SPC+   C +GG C  + G    C+C  GW+G  C + V  C      P  C   
Sbjct: 2608 QCHA-SPCSLMKCGNGGTCIES-GTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 824  GICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN 856
              C +L   ++C C  G TG  C+Q ++  DP+
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQALSISDPS 2698



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 32/78 (41%), Positives = 40/78 (51%), Gaps = 3/78 (3%)

Query: 847  DQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTC-TDH 904
            D D   C  N C NGG C     +FSC CLP +AG  C + V  CL+N C     C  D 
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQ 2931

Query: 905  VASFTCTCPPGYGGFHCE 922
              S++C C  G+ G +CE
Sbjct: 2932 SFSYSCLCTLGWVGRYCE 2949



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 11/99 (11%)

Query: 844  PSCDQDINDCDPNPCL-----NGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC-----LS 893
            P+  + +  C  +PC      NGG+C +   S  C+C  G+ G  C   V  C       
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP 2659

Query: 894  NPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPS 931
            + C  G TC      +TC CP G  G +CEQ L    PS
Sbjct: 2660 HHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPS 2698



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 2/77 (2%)

Query: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATC-HDR 332
            D D      N C NGG C       SC C+  W G +C+Q++  C   +C H + C  D+
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQ 2931

Query: 333  VASFYCACPMGKTGLLC 349
              S+ C C +G  G  C
Sbjct: 2932 SFSYSCLCTLGWVGRYC 2948



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 31/105 (29%), Positives = 44/105 (41%), Gaps = 17/105 (16%)

Query: 1001 VDWCSRQPCQNGGRCV--QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAG 1058
            V WC+   C+N G C+      +C CP  +SG+LC   S                 C  G
Sbjct: 2336 VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCE------------NNPCGNG 2383

Query: 1059 GQCVDEDSSH-YCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGY 1102
              CV +  +   C+CP GR+G  C   ++  + QP   G    GY
Sbjct: 2384 ATCVPKSGTDIVCLCPYGRSGPLCTDAIN--ITQPRFSGTDAFGY 2426



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 2/66 (3%)

Query: 168  CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPG 227
            CR+ GTC++   +  C+CP  Y+G LC+     C  +PC NG TC         C C  G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVCLCPYG 2401

Query: 228  FEGQNC 233
              G  C
Sbjct: 2402 RSGPLC 2407



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 27/87 (31%), Positives = 35/87 (40%), Gaps = 5/87 (5%)

Query: 122  PCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP----CRHGGTCLNT 177
            PC    C +G  C +       C+C  G++G  C   V  C         C  G TC++ 
Sbjct: 2613 PCSLMKCGNGGTC-IESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL 2671

Query: 178  PGSFRCQCPAGYTGPLCENPAVPCAPS 204
            P  + C CP G TG  CE       PS
Sbjct: 2672 PHGYTCFCPLGTTGIYCEQALSISDPS 2698



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 26/78 (33%), Positives = 38/78 (48%), Gaps = 3/78 (3%)

Query: 507  DVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCV-DGIA 564
            D   C    CRNG +C      + CRC   + G  C+++V  C  + C H   C+ D   
Sbjct: 2875 DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSF 2933

Query: 565  SFSCACAPGYTGTRCESQ 582
            S+SC C  G+ G  CE++
Sbjct: 2934 SYSCLCTLGWVGRYCENK 2951



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 881  GPRCARDVDECLSNPCG------PGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCF 934
            G +   +V +C    CG       G CT +  +F+C C P + G  C Q +  C  + C 
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCL 2922

Query: 935  NGGTCV-DGVNSFSCLCRPGYTGAHCQHE 962
            +   C+ D   S+SCLC  G+ G +C+++
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYCENK 2951



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 93/368 (25%), Positives = 124/368 (33%), Gaps = 78/368 (21%)

Query: 308  GESCSQ-NIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP------- 359
            G S  Q +   C+   C +G TC +   S YC C  G  G  C  +     +P       
Sbjct: 2603 GRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFC-TETVSTCDPEHDPPHH 2661

Query: 360  CHEDAICDTNPVNGRAICTCPPGFTGGACDQ--DVDECSIGANPCE-------HLGRCVN 410
            C   A C + P      C CP G TG  C+Q   + + S  +N          H+ +  +
Sbjct: 2662 CSRGATCISLPHG--YTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTH 2719

Query: 411  TQGSFLCQCGRG---YTGPRCETDVNECLSGPCRNQATCL-----DRI------------ 450
             Q  F      G   Y     +    + L     N +  L     DR             
Sbjct: 2720 IQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTIN 2779

Query: 451  GQFTCICMAGFTGTYCEVDIDEC---------QSSPCVN-----GGVCK-DRVNGFSC-T 494
            G    I  AG  G    +D+D            SS   N     GGV   + VN  +   
Sbjct: 2780 GSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIEN 2839

Query: 495  CPSGFSGSTCQLDVDECASTPCRNGAK---CVDQPDGYECRCAEGFEGTLCDRNVDDCSP 551
             P GF G   Q+ ++         GAK    V   DG  C       G    RN  +C+ 
Sbjct: 2840 EPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTAC-------GYNTCRNGGECT- 2891

Query: 552  DPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCL-DLVDKYLCRCPS 610
                    V+G  +FSC C P + G  C   V  C +  C H   C+ D    Y C C  
Sbjct: 2892 --------VNG-TTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLCTL 2941

Query: 611  GTTGVNCE 618
            G  G  CE
Sbjct: 2942 GWVGRYCE 2949



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 5/71 (7%)

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQ-----PCQHGGTCRGYMGGYMCE 1109
            C  GG C++  +S YC C  G  GS C + V  C  +      C  G TC     GY C 
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678

Query: 1110 CLPGYNGDNCE 1120
            C  G  G  CE
Sbjct: 2679 CPLGTTGIYCE 2689



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 25/72 (34%), Positives = 28/72 (38%)

Query: 737  ACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVC 796
            AC    CR GG C+ +G  F C C P   G  C     C  N C H   C         C
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 797  SCPQGWQGPRCQ 808
             C  GW G  C+
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 231  QNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGT 290
            +NC  +V  C  H C N GTC+       C+CP  ++G+ C         + N C NG T
Sbjct: 2332 ENC--HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC----QFASCENNPCGNGAT 2385

Query: 291  CFNTLGGH-SCVCVNGWTGESCSQNID 316
            C    G    C+C  G +G  C+  I+
Sbjct: 2386 CVPKSGTDIVCLCPYGRSGPLCTDAIN 2412



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 652  PLCNVEINECASSPC-----GEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC--AHEP- 703
            P     + +C +SPC     G GG+C++      C C  G     C      C   H+P 
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP 2659

Query: 704  --CSHGI-CYDAPGGFRCVCEPGWSGPRCSQSLA 734
              CS G  C   P G+ C C  G +G  C Q+L+
Sbjct: 2660 HHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS 2693



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 4/77 (5%)

Query: 698  PCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQP---CRAGGTCSSDG 753
            PC+   C +G  C ++     C C  GW G  C+++++    E  P   C  G TC S  
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP 2672

Query: 754  MGFHCTCPPGVQGRQCE 770
             G+ C CP G  G  CE
Sbjct: 2673 HGYTCFCPLGTTGIYCE 2689



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 28/87 (32%), Positives = 39/87 (44%), Gaps = 2/87 (2%)

Query: 149  GYQGRSCRSDVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCR 207
            G +G S   D D    G   CR+GG C     +F C+C   + G  C N +V C  + C 
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC-NQSVSCLNNLCL 2922

Query: 208  NGGTCRQSGDLTYDCACLPGFEGQNCE 234
            +   C      +Y C C  G+ G+ CE
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 34/114 (29%), Positives = 42/114 (36%), Gaps = 16/114 (14%)

Query: 473  CQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQP-DGYEC 531
            C    C N G C        C CP  +SG  CQ     C + PC NGA CV +      C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPKSGTDIVC 2396

Query: 532  RCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDE 585
             C  G  G LC   ++   P              FS   A GYT     S++ +
Sbjct: 2397 LCPYGRSGPLCTDAINITQP-------------RFSGTDAFGYTSFLAYSRISD 2437



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 24/90 (26%), Positives = 37/90 (41%), Gaps = 10/90 (11%)

Query: 426  PRCETDVNECLSGPCR-----NQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSS---- 476
            P     V +C + PC      N  TC++      C C  G+ G++C   +  C       
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP 2659

Query: 477  -PCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
              C  G  C    +G++C CP G +G  C+
Sbjct: 2660 HHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 28/78 (35%), Positives = 33/78 (42%), Gaps = 7/78 (8%)

Query: 738  CESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC-ELLSPC-----TPNPCEHGGRCESAPG 791
            C    C  GGTC   G   +C C  G +G  C E +S C      P+ C  G  C S P 
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673

Query: 792  QLPVCSCPQGWQGPRCQQ 809
                C CP G  G  C+Q
Sbjct: 2674 GY-TCFCPLGTTGIYCEQ 2690



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 24/76 (31%), Positives = 31/76 (40%), Gaps = 5/76 (6%)

Query: 928  CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC-----LSRPCLHGGVCSAAHP 982
            CS   C NGGTC++   S  C C  G+ G+ C      C         C  G  C +   
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673

Query: 983  GFRCTCLESFTGPQCQ 998
            G+ C C    TG  C+
Sbjct: 2674 GYTCFCPLGTTGIYCE 2689



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 3/66 (4%)

Query: 402  CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIG-QFTCICMAG 460
            C + G C++   +  C+C R Y+G  C+     C + PC N ATC+ + G    C+C  G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVCLCPYG 2401

Query: 461  FTGTYC 466
             +G  C
Sbjct: 2402 RSGPLC 2407



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 14/84 (16%)

Query: 1004 CSRQPCQNGGRCVQTGAY--CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061
            C    C+NGG C   G    C C P W+G  C+ +S+ C          L  LC     C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN-QSVSC----------LNNLCLHQSLC 2927

Query: 1062 V-DEDSSHYCVCPEGRTGSHCEQE 1084
            + D+  S+ C+C  G  G +CE +
Sbjct: 2928 IPDQSFSYSCLCTLGWVGRYCENK 2951



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 2/72 (2%)

Query: 928  CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHP-GFRC 986
            C  ++C NGG C     +FSC C P + G  C +++  CL+  CLH  +C       + C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC-NQSVSCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 987  TCLESFTGPQCQ 998
             C   + G  C+
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 4/95 (4%)

Query: 1065 DSSHYCVCPEGRTGSHCEQ-EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV 1123
            ++  + +  E R G + E   V  C    C++ GTC        CEC   Y+G  C+   
Sbjct: 2315 NNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--F 2372

Query: 1124 DECASQPCQHGGSCIDLVAR-YLCSCPPGTLGVLC 1157
              C + PC +G +C+       +C CP G  G LC
Sbjct: 2373 ASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 32/91 (35%), Positives = 42/91 (46%), Gaps = 5/91 (5%)

Query: 191  GPLCENPAVP-CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGG 249
            G   EN  VP CA   CRN GTC    +  + C C   + G+ C+     C  + C NG 
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQ--FASCENNPCGNGA 2384

Query: 250  TCVDGVNT-YNCQCPPEWTGQFCTEDVDECQ 279
            TCV    T   C CP   +G  CT+ ++  Q
Sbjct: 2385 TCVPKSGTDIVCLCPYGRSGPLCTDAINITQ 2415



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 25/72 (34%), Positives = 32/72 (44%), Gaps = 2/72 (2%)

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCI-DLVARYLC 1146
            C    C++GG C      + C CLP + G+ C   V  C +  C H   CI D    Y C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 1147 SCPPGTLGVLCE 1158
             C  G +G  CE
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 3/71 (4%)

Query: 435  CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRV-NGFSC 493
            C    CRN  TC+       C C   ++G  C+     C+++PC NG  C  +      C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396

Query: 494  TCPSGFSGSTC 504
             CP G SG  C
Sbjct: 2397 LCPYGRSGPLC 2407



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 6/86 (6%)

Query: 309  ESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDT 368
            E+C  ++  CA  +C +  TC     + +C CP   +G LC    +C +NPC   A C  
Sbjct: 2332 ENC--HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF-ASCENNPCGNGATC-- 2386

Query: 369  NPVNGR-AICTCPPGFTGGACDQDVD 393
             P +G   +C CP G +G  C   ++
Sbjct: 2387 VPKSGTDIVCLCPYGRSGPLCTDAIN 2412



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 23/72 (31%), Positives = 31/72 (43%), Gaps = 4/72 (5%)

Query: 966  CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY---C 1022
            C    C +GG C+     F C CL  + G  C   V  C    C +   C+   ++   C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937

Query: 1023 LCPPGWSGRLCD 1034
            LC  GW GR C+
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 35/130 (26%), Positives = 51/130 (39%), Gaps = 27/130 (20%)

Query: 536  GFEGTLCDRNVDDCS---PDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCR 592
            GF G + D  V++      D   HG+ ++                     V  C    CR
Sbjct: 2304 GFRGCILDLQVNNKEFFIIDEARHGKNIENC------------------HVPWCAHHLCR 2345

Query: 593  HGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG---VCRDGINRYDCVCQPGF 649
            + G C+   +   C CP   +G  C+     C +NPC  G   V + G +   C+C  G 
Sbjct: 2346 NNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTD-IVCLCPYGR 2402

Query: 650  TGPLCNVEIN 659
            +GPLC   IN
Sbjct: 2403 SGPLCTDAIN 2412



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 29/86 (33%), Positives = 41/86 (47%), Gaps = 6/86 (6%)

Query: 804  GPRCQQDVDECAGPA----PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCL 859
            G +   +V +C G A     C   G CT    +FSC C   + G +C+Q ++ C  N CL
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCL 2922

Query: 860  NGGSC-QDGVGSFSCSCLPGFAGPRC 884
            +   C  D   S+SC C  G+ G  C
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYC 2948



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 32/100 (32%), Positives = 40/100 (40%), Gaps = 12/100 (12%)

Query: 1109 ECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGP 1168
            E   G N +NC   V  CA   C++ G+CI       C CP    G LC+    +  P  
Sbjct: 2324 EARHGKNIENCH--VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNP-- 2379

Query: 1169 PLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRCEADIN 1207
                   C +  TCV   G    C CP G +G  C   IN
Sbjct: 2380 -------CGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN 2412



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 29/95 (30%), Positives = 37/95 (38%), Gaps = 12/95 (12%)

Query: 1235 HAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCR 1294
            +AG S  +C    SPC    C +GG C  S     G +  C+C   + G  C     +C 
Sbjct: 2601 NAGRSVGQCHA--SPCSLMKCGNGGTCIES-----GTSVYCNCTTGWKGSFCTETVSTCD 2653

Query: 1295 ELQ-----CPVGVPCQQTPRGPRCACPPGLSGPSC 1324
                    C  G  C   P G  C CP G +G  C
Sbjct: 2654 PEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 24/73 (32%), Positives = 32/73 (43%), Gaps = 4/73 (5%)

Query: 1176 CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
            C +NGTC+       C CP  Y+G  C+     C +  C    T  C+   G    CLC 
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGAT--CVPKSGTDIVCLCP 2399

Query: 1236 AGFSGPRCQTVLS 1248
             G SGP C   ++
Sbjct: 2400 YGRSGPLCTDAIN 2412



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 24/82 (29%), Positives = 31/82 (37%), Gaps = 7/82 (8%)

Query: 960  QHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ-----PCQNGGR 1014
            Q  A PC    C +GG C  +     C C   + G  C   V  C  +      C  G  
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667

Query: 1015 CVQT--GAYCLCPPGWSGRLCD 1034
            C+    G  C CP G +G  C+
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCE 2689



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 4/76 (5%)

Query: 82   CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGR 141
            C    C   G C    V GT  FSCRC   + G  C+    CL++ C H + C       
Sbjct: 2879 CGYNTCRNGGEC---TVNGTT-FSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFS 2934

Query: 142  FLCSCPPGYQGRSCRS 157
            + C C  G+ GR C +
Sbjct: 2935 YSCLCTLGWVGRYCEN 2950



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 27/92 (29%), Positives = 36/92 (39%), Gaps = 9/92 (9%)

Query: 82   CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGR 141
            C    C   G C    ++      C CPR + G  C     C ++PC +GA C       
Sbjct: 2339 CAHHLCRNNGTC----ISDNENLFCECPRLYSGKLCQFAS-CENNPCGNGATCVPKSGTD 2393

Query: 142  FLCSCPPGYQGRSCRSDVDECRVGEPCRHGGT 173
             +C CP G  G  C    D   + +P R  GT
Sbjct: 2394 IVCLCPYGRSGPLC---TDAINITQP-RFSGT 2421



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 1054 LCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMG-GYMCECLP 1112
            LC+  G C+ ++ + +C CP   +G  C  +   C   PC +G TC    G   +C C  
Sbjct: 2343 LCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVCLCPY 2400

Query: 1113 GYNGDNCEDDVD 1124
            G +G  C D ++
Sbjct: 2401 GRSGPLCTDAIN 2412



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 925  LPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVC-SAAHPG 983
            +P C+   C N GTC+    +  C C   Y+G  CQ  +  C + PC +G  C   +   
Sbjct: 2336 VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKSGTD 2393

Query: 984  FRCTCLESFTGPQCQTLVD 1002
              C C    +GP C   ++
Sbjct: 2394 IVCLCPYGRSGPLCTDAIN 2412



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 25/73 (34%), Positives = 31/73 (42%), Gaps = 6/73 (8%)

Query: 699  CAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTC-SSDGMGF 756
            CAH  C ++G C        C C   +SG  C  +    +CE+ PC  G TC    G   
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA----SCENNPCGNGATCVPKSGTDI 2394

Query: 757  HCTCPPGVQGRQC 769
             C CP G  G  C
Sbjct: 2395 VCLCPYGRSGPLC 2407



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 21/88 (23%), Positives = 35/88 (39%), Gaps = 11/88 (12%)

Query: 616  NCEVNIDDCASNPCTF------GVCRDGINRYDCVCQPGFTGPLCNVEINEC-----ASS 664
            N   ++  C ++PC+       G C +      C C  G+ G  C   ++ C        
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH 2660

Query: 665  PCGEGGSCVDGENGFRCLCPPGSLPPLC 692
             C  G +C+   +G+ C CP G+    C
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 24/75 (32%), Positives = 33/75 (44%), Gaps = 4/75 (5%)

Query: 123  CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPG-SF 181
            C  + C +G  C+V     F C C P + G +C   V  C +   C H   C+     S+
Sbjct: 2879 CGYNTCRNGGECTVNGT-TFSCRCLPDWAGNTCNQSVS-C-LNNLCLHQSLCIPDQSFSY 2935

Query: 182  RCQCPAGYTGPLCEN 196
             C C  G+ G  CEN
Sbjct: 2936 SCLCTLGWVGRYCEN 2950



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 4/81 (4%)

Query: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAP 713
            N  +  CA   C   G+C+       C CP      LC   S  C + PC +G  C    
Sbjct: 2333 NCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKS 2390

Query: 714  G-GFRCVCEPGWSGPRCSQSL 733
            G    C+C  G SGP C+ ++
Sbjct: 2391 GTDIVCLCPYGRSGPLCTDAI 2411



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 8/80 (10%)

Query: 620  NIDDCASNPCTFGVCRDG----IN--RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCV 673
            N+ DC    C +  CR+G    +N   + C C P + G  CN  ++ C ++ C     C+
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCI 2928

Query: 674  -DGENGFRCLCPPGSLPPLC 692
             D    + CLC  G +   C
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYC 2948



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 4/69 (5%)

Query: 49   CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108
            C NGG CT +     +C C P W G  C     C +  C  + +C   +   +  +SC C
Sbjct: 2884 CRNGGECT-VNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLC---IPDQSFSYSCLC 2939

Query: 109  PRGFRGPDC 117
              G+ G  C
Sbjct: 2940 TLGWVGRYC 2948



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 30/104 (28%), Positives = 42/104 (40%), Gaps = 5/104 (4%)

Query: 820  CGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS-FSCSCLPG 878
            C  +G C +   +  C C   Y+G  C      C+ NPC NG +C    G+   C C  G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVCLCPYG 2401

Query: 879  FAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCE 922
             +GP C   ++  ++ P   GT      SF          FH E
Sbjct: 2402 RSGPLCTDAIN--ITQPRFSGTDAFGYTSFLAYSRISDISFHYE 2443



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 4/77 (5%)

Query: 1175 RCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC---RSGACHAAHTRDCLQDPGGGFR 1231
            +C + GTC++      C C  G+ G  C   ++ C        H +    C+  P  G+ 
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP-HGYT 2676

Query: 1232 CLCHAGFSGPRCQTVLS 1248
            C C  G +G  C+  LS
Sbjct: 2677 CFCPLGTTGIYCEQALS 2693



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 5/74 (6%)

Query: 699  CAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD-GMGF 756
            C +  C +G  C      F C C P W+G  C+QS+   +C +  C     C  D    +
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV---SCLNNLCLHQSLCIPDQSFSY 2935

Query: 757  HCTCPPGVQGRQCE 770
             C C  G  GR CE
Sbjct: 2936 SCLCTLGWVGRYCE 2949



 Score = 41.6 bits (96), Expect = 0.009
 Identities = 27/79 (34%), Positives = 33/79 (41%), Gaps = 9/79 (11%)

Query: 882  PRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCV- 940
            P CA  +  C +N    GTC     +  C CP  Y G  C+     C  + C NG TCV 
Sbjct: 2337 PWCAHHL--CRNN----GTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVP 2388

Query: 941  DGVNSFSCLCRPGYTGAHC 959
                   CLC  G +G  C
Sbjct: 2389 KSGTDIVCLCPYGRSGPLC 2407



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 27/92 (29%), Positives = 39/92 (42%), Gaps = 8/92 (8%)

Query: 343  GKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPC 402
            GK    CH+   C  + C  +  C ++  N    C CP  ++G  C       S   NPC
Sbjct: 2328 GKNIENCHVP-WCAHHLCRNNGTCISD--NENLFCECPRLYSGKLCQF----ASCENNPC 2380

Query: 403  EHLGRCVNTQGS-FLCQCGRGYTGPRCETDVN 433
             +   CV   G+  +C C  G +GP C   +N
Sbjct: 2381 GNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN 2412



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 7/101 (6%)

Query: 853  CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVAS-FTC 910
            C  + C N G+C     +  C C   ++G  C      C +NPCG G TC     +   C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVC 2396

Query: 911  TCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCR 951
             CP G  G  C   +    P      GT   G  SF    R
Sbjct: 2397 LCPYGRSGPLCTDAINITQPRF---SGTDAFGYTSFLAYSR 2434



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 21/73 (28%), Positives = 30/73 (41%), Gaps = 3/73 (4%)

Query: 1176 CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
            C + G C      F C C P + G  C   ++ C +  C   H   C+ D    + CLC 
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLC--LHQSLCIPDQSFSYSCLCT 2940

Query: 1236 AGFSGPRCQTVLS 1248
             G+ G  C+   S
Sbjct: 2941 LGWVGRYCENKTS 2953



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 22/68 (32%), Positives = 29/68 (42%), Gaps = 2/68 (2%)

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC-RGYMGGYMCECLPG 1113
            C+ GG+C    ++  C C     G+ C Q V  CL   C H   C       Y C C  G
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSCLCTLG 2942

Query: 1114 YNGDNCED 1121
            + G  CE+
Sbjct: 2943 WVGRYCEN 2950



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 4/74 (5%)

Query: 775  CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC-TNLAGSF 833
            C  N C +GG C +  G    C C   W G  C Q V  C     C    +C  + + S+
Sbjct: 2879 CGYNTCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSV-SCLNNL-CLHQSLCIPDQSFSY 2935

Query: 834  SCTCHGGYTGPSCD 847
            SC C  G+ G  C+
Sbjct: 2936 SCLCTLGWVGRYCE 2949



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 3/71 (4%)

Query: 586  CRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF-GVC-RDGINRYDC 643
            C    CR+GG+C      + CRC     G  C  ++  C +N C    +C  D    Y C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 644  VCQPGFTGPLC 654
            +C  G+ G  C
Sbjct: 2938 LCTLGWVGRYC 2948



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 11/83 (13%)

Query: 583  VDECRSQPCR-----HGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDC-----ASNPCTFG 632
            V +C + PC      +GG C++      C C +G  G  C   +  C       + C+ G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 633  -VCRDGINRYDCVCQPGFTGPLC 654
              C    + Y C C  G TG  C
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 5/40 (12%)

Query: 240  CPGHRCLNGGTC-----VDGVNTYNCQCPPEWTGQFCTED 274
            C    C NGGTC       G+ ++ C CP  +TG+FC +D
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 26/90 (28%), Positives = 32/90 (35%), Gaps = 10/90 (11%)

Query: 1116 GDNCED-DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGP 1174
            G N  D D   C    C++GG C      + C C P   G  C      C          
Sbjct: 2868 GSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN-QSVSC-------LNN 2919

Query: 1175 RCLHNGTCV-DLVGGFRCTCPPGYTGLRCE 1203
             CLH   C+ D    + C C  G+ G  CE
Sbjct: 2920 LCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 22/71 (30%), Positives = 27/71 (38%), Gaps = 3/71 (4%)

Query: 661  CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSH-GICY-DAPGGFRC 718
            C  + C  GG C      F C C P      C   S  C +  C H  +C  D    + C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC-NQSVSCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 719  VCEPGWSGPRC 729
            +C  GW G  C
Sbjct: 2938 LCTLGWVGRYC 2948



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 22/65 (33%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 1222 CLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF 1281
            C+ D    F C C   +SG  CQ   + CE+ PC +G  C P      G    C C    
Sbjct: 2350 CISDNENLF-CECPRLYSGKLCQ--FASCENNPCGNGATCVPK----SGTDIVCLCPYGR 2402

Query: 1282 WGPRC 1286
             GP C
Sbjct: 2403 SGPLC 2407



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 20/53 (37%), Positives = 23/53 (43%), Gaps = 6/53 (11%)

Query: 306  WTGESCSQNIDD-CATAVCFHGATCH-----DRVASFYCACPMGKTGLLCHLD 352
            WT  S S      C   VC +G TCH       + SF C CP+  TG  C  D
Sbjct: 2090 WTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 23/82 (28%), Positives = 28/82 (34%), Gaps = 10/82 (12%)

Query: 1292 SCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCR 1351
            +C    C  G  C        C C P  +G +C           + SC    CLH   C 
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQ---------SVSCLNNLCLHQSLCI 2928

Query: 1352 PAPLAPFFRCACAQGWTGPRCE 1373
            P     +  C C  GW G  CE
Sbjct: 2929 PDQSFSY-SCLCTLGWVGRYCE 2949



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 1318 GLSGPSCRSFPGSPPGASNAS-CAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPA 1376
            GL  P      G   G  +AS C+   C +GG+C  +  + +  C C  GW G  C    
Sbjct: 2592 GLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVY--CNCTTGWKGSFCTETV 2649

Query: 1377 AAPEVSEEP--RCPRAA 1391
            +  +   +P   C R A
Sbjct: 2650 STCDPEHDPPHHCSRGA 2666



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 16/41 (39%), Positives = 20/41 (48%), Gaps = 5/41 (12%)

Query: 928  CSPSSCFNGGTC-----VDGVNSFSCLCRPGYTGAHCQHEA 963
            C    C NGGTC       G+ SF C C   +TG  C+ +A
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 15/40 (37%), Positives = 18/40 (45%), Gaps = 5/40 (12%)

Query: 473  CQSSPCVNGGVC-----KDRVNGFSCTCPSGFSGSTCQLD 507
            CQ   C NGG C        +  F C CP  F+G  C+ D
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 17/42 (40%), Positives = 19/42 (45%), Gaps = 5/42 (11%)

Query: 734  ARDACESQPCRAGGTC-----SSDGMGFHCTCPPGVQGRQCE 770
            A   C+   C  GGTC     SS  + F C CP    GR CE
Sbjct: 2099 APSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 21/55 (38%), Positives = 26/55 (47%), Gaps = 13/55 (23%)

Query: 155  CRSDVDECRVGEPCRHGGTC---LNTPG--SFRCQCPAGYTGPLCENPAVPCAPS 204
            C+ DV        C +GGTC     + G  SF+C CP  +TG  CE  A    PS
Sbjct: 2103 CQQDV--------CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPS 2149



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 5/47 (10%)

Query: 192  PLCENPAVPCAPSPCRNGGTCR----QSGDLTYDCACLPGFEGQNCE 234
            P    P+V C    C NGGTC      SG +++ C C   F G+ CE
Sbjct: 2095 PSVAAPSV-CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 20/60 (33%), Positives = 24/60 (40%), Gaps = 11/60 (18%)

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372
            C CP   SG  C+           ASC   PC +G +C P        C C  G +GP C
Sbjct: 2359 CECPRLYSGKLCQF----------ASCENNPCGNGATCVPKSGTDIV-CLCPYGRSGPLC 2407



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 14/81 (17%)

Query: 867  GVGSFSCSCLPGFAGPR-CARDVDECLSNPCGPGTC-----TDHVASFTCTCPPGYGGFH 920
            GV +   S  P  A P  C +DV  C +     GTC     +  + SF C CP  + G  
Sbjct: 2085 GVDTMWTSVSPSVAAPSVCQQDV--CHNG----GTCHAIFLSSGIVSFQCDCPLHFTGRF 2138

Query: 921  CEQDLPDCSPSSCFNGGTCVD 941
            CE+D     PS  FNG + ++
Sbjct: 2139 CEKDAGLFFPS--FNGNSYLE 2157



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 15/40 (37%), Positives = 19/40 (47%), Gaps = 5/40 (12%)

Query: 853  CDPNPCLNGGSC-----QDGVGSFSCSCLPGFAGPRCARD 887
            C  + C NGG+C       G+ SF C C   F G  C +D
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 12/32 (37%), Positives = 15/32 (46%)

Query: 45   DGSPCANGGRCTQLPSREAACLCPPGWVGERC 76
            + +PC NG  C      +  CLCP G  G  C
Sbjct: 2376 ENNPCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 15/43 (34%), Positives = 20/43 (46%)

Query: 1248 SPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVA 1290
            S C+   C +GG C       G ++F C C   F G  CE+ A
Sbjct: 2101 SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 22/78 (28%), Positives = 28/78 (35%), Gaps = 12/78 (15%)

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
            C    C++ G C             C C + + G  C+    SC    C  G  C   P+
Sbjct: 2339 CAHHLCRNNGTCISD-----NENLFCECPRLYSGKLCQFA--SCENNPCGNGATC--VPK 2389

Query: 1310 GPR---CACPPGLSGPSC 1324
                  C CP G SGP C
Sbjct: 2390 SGTDIVCLCPYGRSGPLC 2407


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  517 bits (1332), Expect = e-146
 Identities = 267/750 (35%), Positives = 363/750 (48%), Gaps = 90/750 (12%)

Query: 67  CPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSS 126
           C  GW+G  C     C  G     G C+   + G     CRC  G++G  C   D C+  
Sbjct: 220 CMEGWMGPECN-RAICRQGCSPKHGSCK---LPG----DCRCQYGWQGLYC---DKCIPH 268

Query: 127 P-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-PGSFRCQ 184
           P C HG  C+      + C C   + G+ C  D++ C   +PC +GGTC NT P  ++C 
Sbjct: 269 PGCVHGI-CNEP----WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323

Query: 185 CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHR 244
           CP GY+GP CE     C   PC N G+C+++  L ++C C PG+ G  C  N+DDC  + 
Sbjct: 324 CPEGYSGPNCEIAEHACLSDPCHNRGSCKETS-LGFECECSPGWTGPTCSTNIDDCSPNN 382

Query: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVN 304
           C +GGTC D VN + C CPP+WTG+ C  D +EC+ +P  C N  +C N +  + C C+ 
Sbjct: 383 CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP--CVNAKSCKNLIASYYCDCLP 440

Query: 305 GWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHED 363
           GW G++C  NI+DC    C + A+C D V  + C CP G  G  C  D D C SNPC   
Sbjct: 441 GWMGQNCDININDC-LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNG 499

Query: 364 AICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
             C  N +N R  C CP GF+G  C  D+D C    NPC++  +C N    + C+C   Y
Sbjct: 500 GHCQ-NEIN-RFQCLCPTGFSGNLCQLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDY 555

Query: 424 TGPRCETDVNECLSGPCRNQATCLDRI----------------------------GQFTC 455
            G  C    + C + PC    +C   +                            G+FTC
Sbjct: 556 EGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTC 615

Query: 456 ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTP 515
            C  GFTGTYC  +I++C+S+PC NGG C D VN + C C  G+ G+ C+ ++++C+  P
Sbjct: 616 DCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNP 675

Query: 516 CRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH-GRCVDGIASFSCACAPGY 574
           C NG  C D  + + C C  G++G  C      C    C++ G C D   +F C C  G+
Sbjct: 676 CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW 735

Query: 575 TGTRCE-SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFG 632
            GT C  ++   C   PC +GG C+   + + C C  G  G  C  N +DC+ +PC   G
Sbjct: 736 EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSG 795

Query: 633 VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC 692
            C DG N Y C C PGF GP C + INEC SSPC  G +CVD  NG+RC+CPPG     C
Sbjct: 796 TCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC 855

Query: 693 LPPS-HPCA------------HEPCSHGICYDAPGGFRCVCEPGWSGPR----------C 729
              S  PC              + C+   C +     R  C   W GPR          C
Sbjct: 856 QEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNG----RIACSKVWCGPRPCLLHKGHSEC 911

Query: 730 SQS-----LARDACESQPCRAGGTCSSDGM 754
                   +  D C   PC   G C S  +
Sbjct: 912 PSGQSCIPILDDQCFVHPCTGVGECRSSSL 941



 Score =  474 bits (1220), Expect = e-133
 Identities = 258/759 (33%), Positives = 348/759 (45%), Gaps = 87/759 (11%)

Query: 302  CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFY----CACPMGKTGLLCHLDDACVS 357
            C+ GW G  C++       A+C  G  C  +  S      C C  G  GL C   D C+ 
Sbjct: 220  CMEGWMGPECNR-------AICRQG--CSPKHGSCKLPGDCRCQYGWQGLYC---DKCIP 267

Query: 358  NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT-QGSFL 416
            +P     IC     N    C C   + G  CD+D++ C     PC + G C NT    + 
Sbjct: 268  HPGCVHGIC-----NEPWQCLCETNWGGQLCDKDLNYCGTH-QPCLNGGTCSNTGPDKYQ 321

Query: 417  CQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSS 476
            C C  GY+GP CE   + CLS PC N+ +C +    F C C  G+TG  C  +ID+C  +
Sbjct: 322  CSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPN 381

Query: 477  PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEG 536
             C +GG C+D VNGF C CP  ++G TCQLD +EC + PC N   C +    Y C C  G
Sbjct: 382  NCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPG 441

Query: 537  FEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGK 596
            + G  CD N++DC     +   C D +  + C C PGY G  CE  +DEC S PC +GG 
Sbjct: 442  WMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGH 501

Query: 597  CLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCN 655
            C + ++++ C CP+G +G  C+++ID C  NPC  G  C +  + Y C C   + G  C+
Sbjct: 502  CQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCS 561

Query: 656  VEINECASSP---------------------------CGEGGSCVDGENG-FRCLCPPGS 687
               + C ++P                           CG  G C     G F C C  G 
Sbjct: 562  HLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGF 621

Query: 688  LPPLCLPPSHPCAHEPCSH-GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
                C    + C   PC + G C D    ++C+C  GW G  C  ++  + C   PC  G
Sbjct: 622  TGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI--NDCSQNPCHNG 679

Query: 747  GTCSSDGMGFHCTCPPGVQGRQCELL-SPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGP 805
            GTC      F+C C  G +G+ C    S C    C +GG C    G    C CP GW+G 
Sbjct: 680  GTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYD-EGDAFKCMCPGGWEGT 738

Query: 806  RCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQ 865
             C    +    P PC   G C     SF+C C  G+ GP C Q+ NDC P+PC N G+C 
Sbjct: 739  TCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCV 798

Query: 866  DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQD 924
            DG   + C C PGFAGP C  +++EC S+PC  G TC D +  + C CPPG+ G  C+  
Sbjct: 799  DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ-- 856

Query: 925  LPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGV-CSAAHPG 983
              + S   C   G+ +               GA    + + C    CL+G + CS    G
Sbjct: 857  --EVSGRPCITMGSVIP-------------DGAKWDDDCNTC---QCLNGRIACSKVWCG 898

Query: 984  FRCTCL------ESFTGPQC-QTLVDWCSRQPCQNGGRC 1015
             R  CL      E  +G  C   L D C   PC   G C
Sbjct: 899  PR-PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGEC 936



 Score =  462 bits (1188), Expect = e-129
 Identities = 247/746 (33%), Positives = 344/746 (46%), Gaps = 84/746 (11%)

Query: 645  CQPGFTGPLCNVEINECASSPCGEGGSC-VDGENGFRCLCP---PGSLPPLCLPPSHPCA 700
            C  G+ GP CN  I     SP  + GSC + G+    C C     G     C+P      
Sbjct: 220  CMEGWMGPECNRAICRQGCSP--KHGSCKLPGD----CRCQYGWQGLYCDKCIP------ 267

Query: 701  HEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACES-QPCRAGGTCSSDGMG-FHC 758
            H  C HGIC +    ++C+CE  W G  C + L  + C + QPC  GGTCS+ G   + C
Sbjct: 268  HPGCVHGICNEP---WQCLCETNWGGQLCDKDL--NYCGTHQPCLNGGTCSNTGPDKYQC 322

Query: 759  TCPPGVQGRQCELLS-PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGP 817
            +CP G  G  CE+    C  +PC + G C+        C C  GW GP C  ++D+C+ P
Sbjct: 323  SCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFE-CECSPGWTGPTCSTNIDDCS-P 380

Query: 818  APCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLP 877
              C   G C +L   F C C   +TG +C  D N+C+  PC+N  SC++ + S+ C CLP
Sbjct: 381  NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLP 440

Query: 878  GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG 937
            G+ G  C  ++++CL       +C D V  + C CPPGY G HCE+D+ +C+ + C NGG
Sbjct: 441  GWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG 500

Query: 938  TCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQC 997
             C + +N F CLC  G++G  CQ + D C   PC +G  C      + C C E + G  C
Sbjct: 501  HCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560

Query: 998  QTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
              L D C   PC+    C    A    P G       +R +               +C  
Sbjct: 561  SHLKDHCRTTPCEVIDSCTVAMASNDTPEG-------VRYIS------------SNVCGP 601

Query: 1058 GGQCVDEDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNG 1116
             G+C  +    + C C +G TG++C + ++ C + PC++GGTC   +  Y C C  G+ G
Sbjct: 602  HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661

Query: 1117 DNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRC 1176
              CE ++++C+  PC +GG+C DLV  + C C  G  G  C   +  C           C
Sbjct: 662  AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEA-------TC 714

Query: 1177 LHNGTCVDLVGGFRCTCPPGYTGLRCE-ADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
             + GTC D    F+C CP G+ G  C  A  + C    CH   T  C+ + G  F C+C 
Sbjct: 715  NNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGT--CVVN-GESFTCVCK 771

Query: 1236 AGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRE 1295
             G+ GP C    + C   PC + G C       G   + C CA  F GP C      C+ 
Sbjct: 772  EGWEGPICAQNTNDCSPHPCYNSGTC-----VDGDNWYRCECAPGFAGPDCRININECQS 826

Query: 1296 LQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGS---------PPGAS-NASCAAAPCL 1345
              C  G  C     G RC CPPG SG  C+   G          P GA  +  C    CL
Sbjct: 827  SPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCL 886

Query: 1346 HGGSCRPAPLAPFFRCACAQGWTGPR 1371
            +G            R AC++ W GPR
Sbjct: 887  NG------------RIACSKVWCGPR 900



 Score =  362 bits (930), Expect = 2e-99
 Identities = 235/751 (31%), Positives = 321/751 (42%), Gaps = 98/751 (13%)

Query: 797  SCPQGWQGPRCQQDVDECAGPAPCGP-HGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP 855
            +C +GW GP C + +        C P HG C  L G   C C  G+ G  CD+    C P
Sbjct: 219  TCMEGWMGPECNRAICRQG----CSPKHGSC-KLPGD--CRCQYGWQGLYCDK----CIP 267

Query: 856  NPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSN-PC-GPGTCTDHVAS-FTCTC 912
            +P    G C +    + C C   + G  C +D++ C ++ PC   GTC++     + C+C
Sbjct: 268  HPGCVHGICNE---PWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSC 324

Query: 913  PPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL 972
            P GY G +CE     C    C N G+C +    F C C PG+TG  C    D C    C 
Sbjct: 325  PEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCS 384

Query: 973  HGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA--YCLCPPGWSG 1030
            HGG C     GF+C C   +TG  CQ   + C  +PC N   C    A  YC C PGW G
Sbjct: 385  HGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMG 444

Query: 1031 RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA 1090
            + CDI    C          L Q CQ    C D  + + C+CP G  G HCE+++D C +
Sbjct: 445  QNCDININDC----------LGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS 493

Query: 1091 QPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPP 1150
             PC +GG C+  +  + C C  G++G+ C+ D+D C   PCQ+G  C +  + Y C CP 
Sbjct: 494  NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPE 553

Query: 1151 GTLGVLCEINEDDCGPGP--PLDS------------GPR------CLHNGTCVDLVGG-F 1189
               G  C   +D C   P   +DS            G R      C  +G C    GG F
Sbjct: 554  DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKF 613

Query: 1190 RCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP 1249
             C C  G+TG  C  +IN+C S  C    T  C+ D    ++C+C  G+ G  C+T ++ 
Sbjct: 614  TCDCNKGFTGTYCHENINDCESNPCRNGGT--CI-DGVNSYKCICSDGWEGAYCETNIND 670

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
            C   PC +GG CR          F C C   + G  C      C E  C  G  C     
Sbjct: 671  CSQNPCHNGGTCRDLVND-----FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD 725

Query: 1310 GPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTG 1369
              +C CP G  G +C         A N+SC   PC +GG+C        F C C +GW G
Sbjct: 726  AFKCMCPGGWEGTTCNI-------ARNSSCLPNPCHNGGTC--VVNGESFTCVCKEGWEG 776

Query: 1370 PRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCE 1429
            P C       + S  P      C       RC  EC     G+ G DC +++     +C+
Sbjct: 777  PIC--AQNTNDCSPHPCYNSGTCVDGDNWYRC--EC---APGFAGPDCRINI----NECQ 825

Query: 1430 ALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYC---ADHFADG-RCD 1485
            +  C      + C    +   C+     C  G     C  V  + C        DG + D
Sbjct: 826  SSPC---AFGATCVDEINGYRCV-----CPPGHSGAKCQEVSGRPCITMGSVIPDGAKWD 877

Query: 1486 QGCNTEECGWDGLDCASEV-----PALLARG 1511
              CNT +C  +G    S+V     P LL +G
Sbjct: 878  DDCNTCQC-LNGRIACSKVWCGPRPCLLHKG 907



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 85/320 (26%), Positives = 115/320 (35%), Gaps = 78/320 (24%)

Query: 1184 DLVGGFRC------TCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
            D  G + C      TC  G+ G  C   I  CR G C   H    L  PG    C C  G
Sbjct: 205  DFFGHYACDQNGNKTCMEGWMGPECNRAI--CRQG-CSPKHGSCKL--PGD---CRCQYG 256

Query: 1238 FSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLT---FTCHCAQPFWGPRCERVARSCR 1294
            + G  C                +C P PG   G+    + C C   + G  C++    C 
Sbjct: 257  WQGLYCD---------------KCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCG 301

Query: 1295 ELQ-CPVGVPCQQT-PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
              Q C  G  C  T P   +C+CP G SGP+C          +  +C + PC + GSC+ 
Sbjct: 302  THQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE--------IAEHACLSDPCHNRGSCKE 353

Query: 1353 APLAPFFRCACAQGWTGPRCEA---PAAAPEVSEEPRCP------RAACQAKRGDQRCD- 1402
              L   F C C+ GWTGP C       +    S    C       +  C  +   + C  
Sbjct: 354  TSLG--FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL 411

Query: 1403 --RECNSPGC-------------------GWDGGDCSLSVGDPWRQCE-ALQCWRLFNNS 1440
               EC +  C                   GW G +C +++ D   QC+    C  L N  
Sbjct: 412  DANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGY 471

Query: 1441 R--CDPACSSPACLYDNFDC 1458
            R  C P  +   C  D  +C
Sbjct: 472  RCICPPGYAGDHCERDIDEC 491


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  477 bits (1228), Expect = e-134
 Identities = 264/750 (35%), Positives = 341/750 (45%), Gaps = 67/750 (8%)

Query: 302  CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCH 361
            C++GW G+ C + +      +   G T         C C  G  G  C   D CV  P  
Sbjct: 231  CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC---DECVPYPGC 282

Query: 362  EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQ-GSFLCQCG 420
                C   P      C C   + G  CD+D++ C    +PC + G C+N +   + C C 
Sbjct: 283  VHGSC-VEPWQ----CNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAEPDQYRCTCP 336

Query: 421  RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVN 480
             GY+G  CE   + C S PC N  +C +    F C C +G++G  C +DIDEC S+PC  
Sbjct: 337  DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396

Query: 481  GGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT 540
            GG C D+V+GF C CP  + G+TCQLD +EC   PC N   C +   GY C C  G++G 
Sbjct: 397  GGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGI 456

Query: 541  LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
             C  NV+DC     H G C D +  + C C  G+ G  CE + DEC S PC  GG C DL
Sbjct: 457  NCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDL 516

Query: 601  VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEIN 659
             D + C CP G +G  CEV++D C  +PC  G  C +    Y C C   F G  C+V   
Sbjct: 517  ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE 576

Query: 660  EC-----------------------ASSPCGEGGSCVDGENG-FRCLCPPGSLPPLCLPP 695
             C                       AS  CG  G CV    G F C+C  G     C   
Sbjct: 577  PCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 636

Query: 696  SHPCAHEPCSH-GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM 754
               C  +PC + G C D    FRC C  GW G  C  +   + C   PC + G C     
Sbjct: 637  IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN--PNDCLPDPCHSRGRCYDLVN 694

Query: 755  GFHCTCPPGVQGRQCELLS-PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDE 813
             F+C C  G +G+ C      C    C +GG C  + G    C+CP GW+G  C    + 
Sbjct: 695  DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS-GDTFRCACPPGWKGSTCAVAKNS 753

Query: 814  CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSC 873
               P PC   G C     SFSC C  G+ G +C  + NDC+P PC NGG C DGV  F C
Sbjct: 754  SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813

Query: 874  SCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS 932
             C PGFAGP C  ++DEC S+PC  G TC D +  + C+CPPG  G  C++ +      S
Sbjct: 814  ECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRS 871

Query: 933  CFNGGTCVDGVNSF-----SCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSA--AHPGFR 985
            C++ GT     +S+     SC C  G            C  +PCL  G   A  A     
Sbjct: 872  CWSRGTPFPHGSSWVEDCNSCRCLDGRRDC----SKVWCGWKPCLLAGQPEALSAQCPLG 927

Query: 986  CTCLESFTGPQCQTLVDWCSRQPCQNGGRC 1015
              CLE   G         C R PC+  G C
Sbjct: 928  QRCLEKAPGQ--------CLRPPCEAWGEC 949



 Score =  447 bits (1150), Expect = e-125
 Identities = 253/765 (33%), Positives = 338/765 (44%), Gaps = 111/765 (14%)

Query: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
           C  G+ G +C            HG  C+V  +    C C  G+QGR C    DEC     
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGG-CTVPGE----CRCSYGWQGRFC----DECVPYPG 281

Query: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPS-PCRNGGTCRQSGDLTYDCACLP 226
           C HG +C+     ++C C   + G LC+     C    PC NGGTC  +    Y C C  
Sbjct: 282 CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337

Query: 227 GFEGQNCE--------------------------------------VNVDDCPGHRCLNG 248
           G+ G+NCE                                      +++D+C  + C  G
Sbjct: 338 GYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAG 397

Query: 249 GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTG 308
           GTCVD V+ + C CP +W G  C  D +EC+ +P  C N  +C N +GG+ C C+ GW G
Sbjct: 398 GTCVDQVDGFECICPEQWVGATCQLDANECEGKP--CLNAFSCKNLIGGYYCDCIPGWKG 455

Query: 309 ESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICD 367
            +C  N++DC    C HG TC D V  + C CP G  G  C L+ D C S+PCH   +C+
Sbjct: 456 INCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCE 514

Query: 368 TNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPR 427
              +     C CP GF+G  C+ DVD C    +PC +  RC N +G + C C   + G  
Sbjct: 515 --DLADGFHCHCPQGFSGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKN 570

Query: 428 CETDVNECLSGPCR-----------------------NQATCLDRI-GQFTCICMAGFTG 463
           C      C  G CR                           C+ +  G F+CIC +GFTG
Sbjct: 571 CSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG 630

Query: 464 TYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCV 523
           TYC  +ID+C   PC NGG C D V+ F C CPSG+ G  C  + ++C   PC +  +C 
Sbjct: 631 TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY 690

Query: 524 DQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH-GRCVDGIASFSCACAPGYTGTRCE-S 581
           D  + + C C +G++G  C      C    C + G C D   +F CAC PG+ G+ C  +
Sbjct: 691 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVA 750

Query: 582 QVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINR 640
           +   C   PC +GG C+     + C C  G  G  C  N +DC   PC   G+C DG+N 
Sbjct: 751 KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 810

Query: 641 YDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPP---------- 690
           + C C PGF GP C + I+EC SSPC  G +CVD  NG+RC CPPG   P          
Sbjct: 811 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGR 870

Query: 691 LCLPPSHPCAH-----EPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRA 745
            C     P  H     E C+   C D     R  C   W G +      +    S  C  
Sbjct: 871 SCWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSKVWCGWKPCLLAGQPEALSAQCPL 926

Query: 746 GGTCSSDGMGFHCTCPP----GVQGRQCELLSPCTPNPCEHGGRC 786
           G  C     G  C  PP    G  G +    +PC P        C
Sbjct: 927 GQRCLEKAPG-QCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970



 Score =  402 bits (1032), Expect = e-111
 Identities = 240/696 (34%), Positives = 316/696 (45%), Gaps = 86/696 (12%)

Query: 43  CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQ-LEDPCHSGPCAGRGVCQSSVVAGT 101
           C    PC NGG C      +  C CP G+ G  C+  E  C S PCA  G C   V +G 
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH-EVPSG- 368

Query: 102 ARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
             F C CP G+ GP C+L  D C S+PCA G  C    DG F C CP  + G +C+ D +
Sbjct: 369 --FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQWVGATCQLDAN 425

Query: 161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT- 219
           EC  G+PC +  +C N  G + C C  G+ G  C      C    C++GGTC+   DL  
Sbjct: 426 ECE-GKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR-GQCQHGGTCK---DLVN 480

Query: 220 -YDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278
            Y C C  GF G++CE+  D+C    C +GG C D  + ++C CP  ++G  C  DVD C
Sbjct: 481 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC 540

Query: 279 QLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCS-----------QNIDDC--------- 318
             +P+ C NG  C+N  G + C C + + G++CS           + ID C         
Sbjct: 541 --EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMP 598

Query: 319 ---ATAVCF-HGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNG 373
              A+ VC  HG        +F C C  G TG  CH + D C+  PC     C       
Sbjct: 599 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAF 658

Query: 374 RAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN 433
           R  C CP G+ G  CD + ++C    +PC   GRC +    F C C  G+ G  C +   
Sbjct: 659 R--CFCPSGWEGELCDTNPNDCL--PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 714

Query: 434 ECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEV-DIDECQSSPCVNGGVCKDRVNGFS 492
           +C +  C N  TC D    F C C  G+ G+ C V     C  +PCVNGG C      FS
Sbjct: 715 QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 774

Query: 493 CTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPD 552
           C C  G+ G TC  + ++C   PC NG  CVD  + + C CA GF G  C  N+D+C   
Sbjct: 775 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 834

Query: 553 PCHHG-RCVDGIASFSCACAPGYTGTRCESQVD---EC--RSQPCRHGGKCLDLVDKYLC 606
           PC +G  CVD I  + C+C PG  G RC+  +     C  R  P  HG   ++  D   C
Sbjct: 835 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE--DCNSC 892

Query: 607 RCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPC 666
           RC  G           DC+   C +  C           QP            E  S+ C
Sbjct: 893 RCLDGRR---------DCSKVWCGWKPCL-------LAGQP------------EALSAQC 924

Query: 667 GEGGSCVDGENGFRCLCPPGSLPPLC---LPPSHPC 699
             G  C++   G +CL PP      C    PPS PC
Sbjct: 925 PLGQRCLEKAPG-QCLRPPCEAWGECGAEEPPSTPC 959



 Score =  359 bits (922), Expect = 2e-98
 Identities = 240/749 (32%), Positives = 319/749 (42%), Gaps = 90/749 (12%)

Query: 797  SCPQGWQGPRCQQDVDECAGPAPCGP-HGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP 855
            +C  GW G  C++ V +      C   HG CT + G   C C  G+ G  CD+    C P
Sbjct: 230  ACMDGWMGKECKEAVCKQG----CNLLHGGCT-VPGE--CRCSYGWQGRFCDE----CVP 278

Query: 856  NPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSN-PC-GPGTCTD-HVASFTCTC 912
             P    GSC   V  + C+C   + G  C +D++ C S+ PC   GTC +     + CTC
Sbjct: 279  YPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTC 335

Query: 913  PPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL 972
            P GY G +CE+    C+ + C NGG+C +  + F C C  G++G  C  + D C S PC 
Sbjct: 336  PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395

Query: 973  HGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLCPPGWSG 1030
             GG C     GF C C E + G  CQ   + C  +PC N   C     G YC C PGW G
Sbjct: 396  AGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKG 455

Query: 1031 RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA 1090
              C I    CR             CQ GG C D  + + CVCP G  G HCE E D C +
Sbjct: 456  INCHINVNDCRGQ-----------CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 504

Query: 1091 QPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPP 1150
             PC  GG C     G+ C C  G++G  CE DVD C   PC++G  C +L   Y C+CP 
Sbjct: 505  SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564

Query: 1151 GTLGVLCEINEDDC---------------GPG-PPLDSGPRCLHNGTCVDLVGG-FRCTC 1193
               G  C +  + C               GPG P   +   C  +G CV   GG F C C
Sbjct: 565  DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624

Query: 1194 PPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQ 1253
              G+TG  C  +I++C    C    T  C+ D    FRC C +G+ G  C T  + C   
Sbjct: 625  DSGFTGTYCHENIDDCLGQPCRNGGT--CI-DEVDAFRCFCPSGWEGELCDTNPNDCLPD 681

Query: 1254 PCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRC 1313
            PC   G+C           F C C   + G  C      C    C  G  C  +    RC
Sbjct: 682  PCHSRGRCYDLVN-----DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736

Query: 1314 ACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
            ACPPG  G +C         A N+SC   PC++GG+C  +  +  F C C  GW G  C 
Sbjct: 737  ACPPGWKGSTCAV-------AKNSSCLPNPCVNGGTCVGSGAS--FSCICRDGWEGRTC- 786

Query: 1374 APAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA--- 1430
                  + +  P      C       RC  EC     G+ G DC +++     +C++   
Sbjct: 787  -THNTNDCNPLPCYNGGICVDGVNWFRC--EC---APGFAGPDCRINID----ECQSSPC 836

Query: 1431 ---LQCWRLFNNSRCD--PACSSPAC---LYDNFDCHAGGRERTCNPVYEKYC-ADHFAD 1481
                 C    N  RC   P  + P C   +     C + G        + + C +    D
Sbjct: 837  AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 896

Query: 1482 GRCDQGCNTEECGWDGLDCASEVPALLAR 1510
            GR D  C+   CGW     A +  AL A+
Sbjct: 897  GRRD--CSKVWCGWKPCLLAGQPEALSAQ 923



 Score =  207 bits (527), Expect = 1e-52
 Identities = 110/287 (38%), Positives = 143/287 (49%), Gaps = 18/287 (6%)

Query: 34  AGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGV 92
           AGPG   P       C   GRC   P    +C+C  G+ G  C    D C   PC   G 
Sbjct: 593 AGPGM--PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 650

Query: 93  CQSSVVAGTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ 151
           C   V A    F C CP G+ G  C   P+ CL  PC    RC       F C+C  G++
Sbjct: 651 CIDEVDA----FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC-YDLVNDFYCACDDGWK 705

Query: 152 GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC---ENPAVPCAPSPCRN 208
           G++C S   +C     C +GGTC ++  +FRC CP G+ G  C   +N +  C P+PC N
Sbjct: 706 GKTCHSREFQCD-AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS--CLPNPCVN 762

Query: 209 GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
           GGTC  SG  ++ C C  G+EG+ C  N +DC    C NGG CVDGVN + C+C P + G
Sbjct: 763 GGTCVGSG-ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAG 821

Query: 269 QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI 315
             C  ++DECQ  P  C  G TC + + G+ C C  G  G  C + I
Sbjct: 822 PDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  462 bits (1190), Expect = e-129
 Identities = 489/1637 (29%), Positives = 603/1637 (36%), Gaps = 318/1637 (19%)

Query: 24   VRALPLLLLLAGP-GAAAPP-----CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQ 77
            V AL LLLL A P GA+ PP        G P     +   L  R   C+       +   
Sbjct: 15   VLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCV-------QALS 67

Query: 78   LEDPCHSGPCAGRGVCQS------------SVVAGTARFSCRCPRGF-RGPDCS--LPDP 122
               P     C  +  C               V    AR   RC RG+ + PD    L   
Sbjct: 68   HTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSAE 127

Query: 123  CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP-CRHGGTCLNTPGSF 181
            C +S C HG RC   P     C CPPG+QG  C+ DVDECR     C+H   C+NTPGS+
Sbjct: 128  CSASLCFHGGRCV--PGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQH--RCVNTPGSY 183

Query: 182  RCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT---YDCACLPGFE----GQNCE 234
             C+C  G+         +        NGG       LT   + C C PGF+    G++C 
Sbjct: 184  LCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC- 242

Query: 235  VNVDDCPGHR--CLNGGTCVDGVNTYNCQCPPEWT--GQFCTEDVDECQLQPNACHNGGT 290
            V    C      C++    V G+    C    +    G+ C EDVDEC      C +G  
Sbjct: 243  VRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC-EDVDECAAGLAQCAHG-- 299

Query: 291  CFNTLGGHSCVCVNGWT----GESCSQ------NIDDCATAVCFHGATCHDRVASFYCAC 340
            C NT G   CVC  G+     G  C +      N  +     C HG  C    A   C C
Sbjct: 300  CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG--CSHTSAGPLCTC 357

Query: 341  PMG----KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF---TGGACDQDVD 393
            P G         C   D C  +PC +  +C  NP  G   C C  G+     G   +DVD
Sbjct: 358  PRGYELDTDQRTCIDVDDCADSPCCQQ-VCTNNP--GGYECGCYAGYRLSADGCGCEDVD 414

Query: 394  ECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQF 453
            EC+     CEH   C N  GSF C C  GY   R   D   C   P       LD    F
Sbjct: 415  ECASSRGGCEH--HCTNLAGSFQCSCEAGY---RLHEDRRGC--SPLEEPMVDLDGELPF 467

Query: 454  T------CICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLD 507
                    +        + + D+   +    + G    +        C     G  C L 
Sbjct: 468  VRPLPHIAVLQDELPQLFQDDDVGADEEEAELRG----EHTLTEKFVCLDDSFGHDCSLT 523

Query: 508  VDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFS 567
             D+C     RNG  C+   DG  C C EG+ G +C+   + C PD            SFS
Sbjct: 524  CDDC-----RNGGTCLLGLDG--CDCPEGWTGLICN---ETCPPDTFGKN------CSFS 567

Query: 568  CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
            C+C  G T   C+S    CR  P   G  C D        CP G  G +C    + CA+ 
Sbjct: 568  CSCQNGGT---CDSVTGACRCPPGVSGTNCED-------GCPKGYYGKHCRKKCN-CANR 616

Query: 628  PCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSP-CGEGGSCV-------DGENGF 679
                G C        C+C PG  G  C++     A  P C E   CV       D  +G 
Sbjct: 617  ----GRCHRLYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDG- 669

Query: 680  RCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACE 739
             C C  G     C          P     C   P G  C    G  G RC      + C 
Sbjct: 670  SCSCKAGFRGERCQAECELGYFGPGCWQAC-TCPVGVACDSVSGECGKRCPAGFQGEDC- 727

Query: 740  SQPCRAG-------GTCSSDGMGFH-----CTCPPGVQGRQCELLSP-------CTP--N 778
             Q C  G        +CS  G   H     C CPPG  G  CE   P       C     
Sbjct: 728  GQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICP 787

Query: 779  PCEHGGRCESAPGQ---LPV-----CS--CPQGWQGPRCQQDVDECAGPAPCGPH-GICT 827
             C+H  RC+   G    LP      C   CP GW GP CQ     CA    C P  G C+
Sbjct: 788  ACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS-CANDGHCHPATGHCS 846

Query: 828  NLAG--SFSC--TCHGGYTGPSCDQDINDCDPNPCLNG-GSCQDGVGSFSCSCLPGFAGP 882
               G   FSC   C  G+ GP C    N      C  G GSC D +    C C  G+ GP
Sbjct: 847  CAPGWTGFSCQRACDTGHWGPDCSHPCN------CSAGHGSC-DAISGL-CLCEAGYVGP 898

Query: 883  RCARDVDECLSNP-------CGPGTCTDHVASFTCTCPPGYGGFHCEQDLP------DC- 928
            RC +   +    P       C  G   DHV+   CTCP G+ G  CE   P      DC 
Sbjct: 899  RCEQQCPQGHFGPGCEQRCQCQHGAACDHVSG-ACTCPAGWRGTFCEHACPAGFFGLDCR 957

Query: 929  SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRP----------CLHGGVCS 978
            S  +C  G  C D VN  SCLC  G  G  C   A+ C +            C +G  C 
Sbjct: 958  SACNCTAGAAC-DAVNG-SCLCPAGRRGPRC---AETCPAHTYGHNCSQACACFNGASCD 1012

Query: 979  AAHPGFRCTCLESFTGPQCQTLV------DWCSRQP-CQNGGRCVQTGAYCLCPPGWSGR 1031
              H   +C C   + GP C          D C     CQNGG C     +C CP GW+G 
Sbjct: 1013 PVHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGL 1070

Query: 1032 LCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCL-- 1089
             C+   LP R+  A  G R    C  GG C  +  +  C+CP G TG  C+    PCL  
Sbjct: 1071 ACEKECLP-RDVRA--GCRHSGGCLNGGLC--DPHTGRCLCPAGWTGDKCQ---SPCLRG 1122

Query: 1090 ------AQ--PCQHGGTCRGYMGGYMCECLPGYNGDNCED-----DVDECASQPCQHGG- 1135
                  AQ   C  G  C    G   C C PG+ G  CE         E  +Q CQ  G 
Sbjct: 1123 WFGEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGE 1180

Query: 1136 --SCIDLVARYLCSCPPGTLGVLCEINEDDCGP---GPPLDSGPRCLHNGTCVDLVGGFR 1190
              +C    A   CSC  G  G  C   +  C P   GP  +    CL+ G+C    G   
Sbjct: 1181 NPACHP--ATGTCSCAAGYHGPSC---QQRCPPGRYGPGCEQLCGCLNGGSCDAATGA-- 1233

Query: 1191 CTCPPGYTGLRCEADINECRSGACHAAHTRDCLQ----DPGGGFRCLCHAGFSGPRCQTV 1246
            C CP G+ G  C     + R G  +  H   C Q    DP  G  CLC  G +G RC+  
Sbjct: 1234 CRCPTGFLGTDCNLTCPQGRFGP-NCTHVCGCGQGAACDPVTG-TCLCPPGRAGVRCERG 1291

Query: 1247 LSP------CE-SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE------RVARSC 1293
                     CE +  C++GG C  S G       +C C   + G  CE      R   +C
Sbjct: 1292 CPQNRFGVGCEHTCSCRNGGLCHASNG-------SCSCGLGWTGRHCELACPPGRYGAAC 1344

Query: 1294 R-ELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASC-AAAPCLHGGSCR 1351
              E  C     C+  P    C C PG  G +C      PPG   A C     C HG  C 
Sbjct: 1345 HLECSCHNNSTCE--PATGTCRCGPGFYGQACEH--PCPPGFHGAGCQGLCWCQHGAPCD 1400

Query: 1352 PAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCG 1411
            P       RC C  G+ G  CE          EP      C      QRCD +  +P C 
Sbjct: 1401 PIS----GRCLCPAGFHGHFCERGC-------EPGSFGEGCH-----QRCDCDGGAP-CD 1443

Query: 1412 WDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVY 1471
               G C    G     C  L C R     +  P+C+          C  GG    C+PV 
Sbjct: 1444 PVTGLCLCPPGRSGATCN-LDCRR----GQFGPSCT--------LHCDCGG-GADCDPVS 1489

Query: 1472 -EKYCADHFADGRCDQG 1487
             + +C D +    C +G
Sbjct: 1490 GQCHCVDGYMGPTCREG 1506



 Score =  171 bits (433), Expect = 8e-42
 Identities = 208/758 (27%), Positives = 269/758 (35%), Gaps = 167/758 (22%)

Query: 852  DCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCG-PGTCTDHVASFTC 910
            +C  + C +GG C  G     C C PGF GPRC  DVDEC ++  G    C +   S+ C
Sbjct: 127  ECSASLCFHGGRCVPGSAQ-PCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLC 185

Query: 911  TCPPGYGGFHCEQDLPDC-SPSSCF--NGGT---CVD-GVNSFSCLCRPGY----TGAHC 959
             C P   GF    D   C + +SC   NGG    CV   +    C CRPG+     G HC
Sbjct: 186  ECKP---GFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 242

Query: 960  QHEADPCLSR--PCLHGGVCSAAHPGFRCTCLESF----TGPQCQTLVDWCSRQPCQNGG 1013
               + PC +R   C+H   C       RC C   +     G  C+  VD C+    Q   
Sbjct: 243  VRRS-PCANRNGSCMHR--CQVVRGLARCECHVGYQLAADGKACED-VDECAAGLAQCAH 298

Query: 1014 RCVQT-GAY-CLCPPGW----SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSS 1067
             C+ T G++ C+C  G+     GR C            +I + +   C+A         S
Sbjct: 299  GCLNTQGSFKCVCHAGYELGADGRQC-----------YRIEMEIVNSCEANNGGCSHGCS 347

Query: 1068 H-----YCVCPEG---RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY--NGD 1117
            H      C CP G    T      +VD C   PC     C    GGY C C  GY  + D
Sbjct: 348  HTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQ-QVCTNNPGGYECGCYAGYRLSAD 406

Query: 1118 NCE-DDVDECASQ--PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGP------ 1168
             C  +DVDECAS    C+H   C +L   + CSC  G       ++ED  G  P      
Sbjct: 407  GCGCEDVDECASSRGGCEH--HCTNLAGSFQCSCEAG-----YRLHEDRRGCSPLEEPMV 459

Query: 1169 ----------PL-------DSGPRCLHNGTC------VDLVGGFRCT----CPPGYTGLR 1201
                      PL       D  P+   +          +L G    T    C     G  
Sbjct: 460  DLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHD 519

Query: 1202 CEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP------CE-SQP 1254
            C    ++CR+G         CL    G   C C  G++G  C     P      C  S  
Sbjct: 520  CSLTCDDCRNGG-------TCLLGLDG---CDCPEGWTGLICNETCPPDTFGKNCSFSCS 569

Query: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE-RVARSCRELQCPVGVPCQQTPRGPR- 1312
            CQ+GG C         +T  C C     G  CE    +      C     C    R  R 
Sbjct: 570  CQNGGTC-------DSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRL 622

Query: 1313 ---CACPPGLSGPSCRSFPGSPPGASNASCA-AAPCL--HGGSCRPAPLAPFFRCACAQG 1366
               C C PGL G  C      PP A    C+    C+  H  SC     +    C+C  G
Sbjct: 623  YGACLCDPGLYGRFCHL--TCPPWAFGPGCSEECQCVQPHTQSCDKRDGS----CSCKAG 676

Query: 1367 WTGPRCEAPAA----APEVSEEPRCP-RAACQAKRGD--QRCDRECNSPGCGWD------ 1413
            + G RC+A        P   +   CP   AC +  G+  +RC        CG +      
Sbjct: 677  FRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTF 736

Query: 1414 GGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFD----------CHAGGR 1463
            G +CS S       C    C  +    RC P  +   C  D  +          C A   
Sbjct: 737  GVNCSSSC-----SCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQH 791

Query: 1464 ERTCNP-VYEKYCADHFADGRCDQGCNTEECGWDGLDC 1500
               C+P      C   F   RC   C     GW G  C
Sbjct: 792  AARCDPETGACLCLPGFVGSRCQDVC---PAGWYGPSC 826


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  461 bits (1186), Expect = e-129
 Identities = 487/1734 (28%), Positives = 677/1734 (39%), Gaps = 432/1734 (24%)

Query: 91   GVCQSSVVAGTARFSCRCPRGF----RGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSC 146
            G C++++      F CRC  GF       +C+  D C  SP   G+   V   G F C C
Sbjct: 1087 GKCRNTI----GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECEC 1142

Query: 147  PPGYQG-----RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP- 200
              GY+      ++C  D+DEC        GGTC+NT GSF+C CP G+         V  
Sbjct: 1143 FEGYESGFMMMKNCM-DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDI 1201

Query: 201  --CAPSP--CRNGGTCRQSGDLTYDCACLPGFEG----QNCEVNVDDCPGHRCLNGGT-- 250
              C+ S   CRNG      G  TY C+C PG++     Q C  ++D+C     +NGG   
Sbjct: 1202 NECSLSDNLCRNGKCVNMIG--TYQCSCNPGYQATPDRQGC-TDIDEC---MIMNGGCDT 1255

Query: 251  -CVDGVNTYNCQCPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305
             C +   +Y C C   +     G+ C  D+DEC+  P+ C +GG C N  G + C+C +G
Sbjct: 1256 QCTNSEGSYECSCSEGYALMPDGRSCA-DIDECENNPDIC-DGGQCTNIPGEYRCLCYDG 1313

Query: 306  WTG----ESCSQ-NIDDCATAVCFHGATCHDRVASFYCACPMG---KTGLL-CHLDDACV 356
            +      ++C   N  D  + +C  G  C +   SF C C +G   K G   C   D C 
Sbjct: 1314 FMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECE 1372

Query: 357  --SNPCHEDAICDTNPVNGRAICTCPPGFTG-GACDQDVDECSIGANPCEHLGRCVNTQG 413
              ++ C   A C   P  G   C+C  G+ G G    D+DECS G + C    +CVNT G
Sbjct: 1373 IGAHNCDMHASCLNIP--GSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPG 1430

Query: 414  SFLCQCGRGYTGP--RCETDVNECLS--GPCRNQATCLDRIGQFTCICMAGFT----GTY 465
            S+ C C  G+TG    C +DV+EC      C N   CL+  G + C C  GFT       
Sbjct: 1431 SYRCACSEGFTGDGFTC-SDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRS 1488

Query: 466  CEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECAS-TPCRNGA 520
            C+ DIDEC        G C +    F C C  G+    +G  C  D+DECA    C NG 
Sbjct: 1489 CQ-DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVNGL 1546

Query: 521  KCVDQPDGYECRCAEGFE----GTLC-DRNVDDC----SPDPCHHGRCVD----GIASFS 567
             CV+ P  YEC C   F+    G  C D  V +C     P       C      G++  S
Sbjct: 1547 -CVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSS 1605

Query: 568  CACAPGYT-GTRCES-----------------------------QVDECRSQP--CRHGG 595
            C C+ G   G  CE+                              +DEC+  P  C+ GG
Sbjct: 1606 CCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQ-GG 1664

Query: 596  KCLDLVDKYLCRCPSG-----TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPG 648
             C++    + C CP G      T + CE +ID+C ++P  C  G C + +  Y C+C P 
Sbjct: 1665 NCINTFGSFQCECPQGYYLSEDTRI-CE-DIDECFAHPGVCGPGTCYNTLGNYTCICPPE 1722

Query: 649  FTGPLCNVEINECASSPCGEGGSCVDGENGFRC--LCPPGSLPPLCLPP-------SHPC 699
            +      +++N   +        C    NG  C    P      +C          + PC
Sbjct: 1723 Y------MQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPC 1776

Query: 700  AHEPCSHGICYDAPG--GFRCVCE--PGWS-GPRCSQSLARDACESQP-CRAGGTCSSDG 753
              EPC        PG   F+ +C   PG++      +++  D C+  P   A G C +  
Sbjct: 1777 --EPC------PTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQI 1828

Query: 754  MGFHCTCPPGVQGRQ----CELLSPCT--PNPCEHGGRCESAPGQLPVCSCPQGWQ-GPR 806
              F C CP G         CE +  C+   N C+    C ++PG    C C  G++  P 
Sbjct: 1829 GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYR-CECAAGFKLSPN 1887

Query: 807  -CQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ----DINDCDPNPCLNG 861
                D +EC        HG+C +L GS+ C CH G+   S DQ    D+++C+ +PC N 
Sbjct: 1888 GACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKA-SQDQTMCMDVDECERHPCGN- 1945

Query: 862  GSCQDGVGSFSCSCLPGF--AGPRCARDVDECLS---NPCGPGTCTDHVASFTCTCPPGY 916
            G+C++ VGS++C C PGF         D+DEC S     C  G C + + SF C C  GY
Sbjct: 1946 GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY 2005

Query: 917  ----GGFHCEQDLPDC--SPSSCFNGGTCVDGVNSFSCLCRPGY--TGAHC----QHEAD 964
                 G +C  D  +C   P SC + GTC +   SF C+C PGY     +C    + + D
Sbjct: 2006 ELTPDGKNC-IDTNECVALPGSC-SPGTCQNLEGSFRCICPPGYEVKSENCIDINECDED 2063

Query: 965  PCLSRPCLHGGVCSAAHPGFRCTCLESF----TGPQC-QTLVDWCSRQPCQNGGRCV--- 1016
            P +   CL G  C+    GF+C C   F     G +C  T   +C        G+C    
Sbjct: 2064 PNI---CLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN--FENGKCSVPK 2117

Query: 1017 ---QTGAYCLCP----PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAG----------- 1058
                T A C C      GW          PC        V  + LC  G           
Sbjct: 2118 AFNTTKAKCCCSKMPGEGWGD--------PCELCPKDDEVAFQDLCPYGHGTVPSLHDTR 2169

Query: 1059 ---------------GQCVDEDSSHYCVCPEG----RTGSHCEQEVDPCLAQPCQHGGTC 1099
                           GQC++ D S  C CP G     TG  C    +  +  PC + GTC
Sbjct: 2170 EDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGN-GTC 2228

Query: 1100 RGYMGGYMCECLPGYNGD---NCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVL 1156
               +G + C C  G+      NCE D++ECA  P      C++    Y C+CP   +G  
Sbjct: 2229 TNVIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCP---IGYA 2284

Query: 1157 CEINEDDCGPGPPLDSGPRCLHN-----GTCVDLVGGFRCTCPPGYT----GLRCEADIN 1207
               ++  C     LD     LH+       C +L+G F C CPPG      G  C  D N
Sbjct: 2285 LREDQKMC---KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDEN 2340

Query: 1208 ECRS--GACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRC-------------QTVLS 1248
            ECR+  G C      + +    G +RC C+ GF    SG  C             QT+  
Sbjct: 2341 ECRTKPGICENGRCVNII----GSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQ 2396

Query: 1249 PC--------ESQPCQHGG-----QCRPSPGPGGGL------------------------ 1271
                      +S+ C  GG     QC   P PG                           
Sbjct: 2397 MASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVM 2456

Query: 1272 --------------TFTCHCAQPFW----GPRCERVARSCRELQCPVGVPCQQTPRGPRC 1313
                          +F C C   +     G  C  +   C +   P    C+ T    +C
Sbjct: 2457 PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL-DECSQSPKPCNYICKNTEGSYQC 2515

Query: 1314 ACPPGL----SGPSCRSFP----------------------GSPPG--------ASNASC 1339
            +CP G      G +C+                           PPG          N  C
Sbjct: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNEC 2575

Query: 1340 AAAPCLHG--GSCRPAPLAPFFRCACAQGW----TGPRCEAPAAAPEVSEEPRCPRAACQ 1393
             + P L G  G C+  P +  F C C +G+    TG  CE      E     RC +  CQ
Sbjct: 2576 GSQPSLCGAKGICQNTPGS--FSCECQRGFSLDATGLNCE---DVDECDGNHRC-QHGCQ 2629

Query: 1394 AKRGDQRCDRECNSPGC--------GW----DGGDCSLSVGDPWRQCEALQCWRLFNNSR 1441
               G  RC       GC         W    D  +CS    +P   C +  C+    + +
Sbjct: 2630 NILGGYRC-------GCPQGYIQHYQWNQCVDENECS----NP-NACGSASCYNTLGSYK 2677

Query: 1442 CDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGW 1495
            C  AC S    +D F          C+ V E  C+   +   C+ GC+  E G+
Sbjct: 2678 C--ACPS-GFSFDQF-------SSACHDVNE--CSS--SKNPCNYGCSNTEGGY 2717



 Score =  451 bits (1161), Expect = e-126
 Identities = 448/1522 (29%), Positives = 619/1522 (40%), Gaps = 274/1522 (18%)

Query: 43   CLDGSPCAN------GGRCTQLPSREAACLCPPGWVG----ERCQLEDPC--HSGPCAGR 90
            C D   C N      GG+CT +P  E  CLC  G++     + C   + C  +S  C   
Sbjct: 1281 CADIDECENNPDICDGGQCTNIPG-EYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF- 1338

Query: 91   GVCQSSVVAGTARFSCRCPRGFR----GPDCSLPDPCL--SSPCAHGARCSVGPDGRFLC 144
            G C+++       F C C  G+        C+  D C   +  C   A C   P G F C
Sbjct: 1339 GECENT----KGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIP-GSFKC 1393

Query: 145  SCPPGYQGRSCRS-DVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGP--LCENPAVP 200
            SC  G+ G   +  D+DEC  G   C     C+NTPGS+RC C  G+TG    C +    
Sbjct: 1394 SCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSD-VDE 1452

Query: 201  CAPSP--CRNGGTCRQSGDLTYDCACLPGF----EGQNCEVNVDDCPGHRCLNGGTCVDG 254
            CA +   C NG      G   Y C C  GF    + ++C+ ++D+C        GTC + 
Sbjct: 1453 CAENINLCENGQCLNVPG--AYRCECEMGFTPASDSRSCQ-DIDECSFQNICVFGTCNNL 1509

Query: 255  VNTYNCQCPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW---- 306
               ++C C   +    TG  CT D+DEC   P  C NG  C NT G + C C   +    
Sbjct: 1510 PGMFHCICDDGYELDRTGGNCT-DIDECA-DPINCVNG-LCVNTPGRYECNCPPDFQLNP 1566

Query: 307  TGESCSQN-IDDCATAVCFHG---ATCHDR----VASFYCACPMGKTG------------ 346
            TG  C  N + +C       G    +C+      V+   C C +GK              
Sbjct: 1567 TGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNS 1626

Query: 347  ----LLCHLDDACVSNP----------CHE-DAICDT-NPVN--GRAICTCPPGF---TG 385
                 LC   +    NP          C E   +C   N +N  G   C CP G+     
Sbjct: 1627 TEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSED 1686

Query: 386  GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG---------------------RGYT 424
                +D+DEC      C   G C NT G++ C C                      R Y 
Sbjct: 1687 TRICEDIDECFAHPGVCGP-GTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745

Query: 425  GPRCETDVNECLSGPCRNQATCLDRIGQ----------------FTCIC--MAGFT---G 463
            G  CE   NE      +    C   +G+                F  IC  + GFT    
Sbjct: 1746 GTTCE---NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIH 1802

Query: 464  TYCEVDIDECQSSP--CVNGGVCKDRVNGFSCTCPSGFSGSTCQL---DVDECASTP--C 516
            T   VDIDEC+  P  C NG VC +++  F C CP+GFS +   L   D+DEC++    C
Sbjct: 1803 TGKAVDIDECKEIPGICANG-VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLC 1861

Query: 517  RNGAKCVDQPDGYECRCAEGFE----GTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAP 572
            +  A C++ P  Y C CA GF+    G   DRN     P+ C HG CVD   S+ C C  
Sbjct: 1862 QRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHN 1921

Query: 573  GYTGTRCESQ---VDECRSQPCRHGGKCLDLVDKYLCRCPSG--TTGVNCEVNIDDCAS- 626
            G+  ++ ++    VDEC   PC +G  C + V  Y C C  G   T  N  ++ID+C+S 
Sbjct: 1922 GFKASQDQTMCMDVDECERHPCGNG-TCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSF 1980

Query: 627  --NPCTFGVCRDGINRYDCVCQPGFT----GPLCNVEINECASSPCG-EGGSCVDGENGF 679
                C  G C + I  + C+C  G+     G  C ++ NEC + P     G+C + E  F
Sbjct: 1981 FGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALPGSCSPGTCQNLEGSF 2039

Query: 680  RCLCPPGS--LPPLCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGW----SGPRC-- 729
            RC+CPPG       C+  +  C  +P  C  G C + PGGF+C+C PG+    +G RC  
Sbjct: 2040 RCICPPGYEVKSENCIDINE-CDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFD 2098

Query: 730  -SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQ-GRQCELLSPCTPNPCEHGGRCE 787
              QS      E+  C      ++      C+  PG   G  CEL      +       C 
Sbjct: 2099 TRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPK--DDEVAFQDLCP 2156

Query: 788  SAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TG 843
               G +P             ++DV+EC        +G C N  GSF C C  GY    TG
Sbjct: 2157 YGHGTVPSLH--------DTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTG 2208

Query: 844  PSCDQDINDCD-PNPCLNGGSCQDGVGSFSCSCLPGFA-GPRC-ARDVDECLSNP--CGP 898
              C  D ++C   NPC NG +C + +GSF C+C  GF  GP     D++EC  NP  C  
Sbjct: 2209 VRC-VDTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCA- 2265

Query: 899  GTCTDHVASFTCTCPPGYGGFHCEQ---DLPDCSPS--SCFNGGT-CVDGVNSFSCLCRP 952
              C +   S+ CTCP GY     ++   DL +C+     C + G  C + + +F C+C P
Sbjct: 2266 FRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPP 2325

Query: 953  GYT----GAHCQHEADPCLSRPCL-HGGVCSAAHPGFRCTCLESF----TGPQCQTLVDW 1003
            G      G  C  E + C ++P +   G C      +RC C E F    +G +C      
Sbjct: 2326 GMARRPDGEGCVDENE-CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLD---- 2380

Query: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
             +RQ     G C       +C    S R    +S  C +     G + E LC   G    
Sbjct: 2381 -NRQ-----GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCE-LCPLPGT--- 2430

Query: 1064 EDSSHYCVCPEGRTGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY----NGD 1117
              + +  +CP G   +   +++D C   P  C +G  C   MG + C C  GY    +G 
Sbjct: 2431 --AQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGT 2487

Query: 1118 NCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCL 1177
            +C D +DEC+  P      C +    Y CSCP G       + ++D      LD      
Sbjct: 2488 SCID-LDECSQSPKPCNYICKNTEGSYQCSCPRGY------VLQEDGKTCKDLDECQTKQ 2540

Query: 1178 HNGT--CVDLVGGFRCTCPPGYTGLRCEA-DINECRSGACHAAHTRDCLQDPGGGFRCLC 1234
            HN    CV+ +GGF C CPPG+T       D NEC S          C   P G F C C
Sbjct: 2541 HNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTP-GSFSCEC 2599

Query: 1235 HAGFS----GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF-----WGPR 1285
              GFS    G  C+ V     +  CQHG  C+   G      + C C Q +     W   
Sbjct: 2600 QRGFSLDATGLNCEDVDECDGNHRCQHG--CQNILG-----GYRCGCPQGYIQHYQWNQC 2652

Query: 1286 CERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCL 1345
             +     C          C  T    +CACP   SG S   F  +    +  S +  PC 
Sbjct: 2653 VDE--NECSNPNACGSASCYNTLGSYKCACP---SGFSFDQFSSACHDVNECSSSKNPCN 2707

Query: 1346 HGGSCRPAPLAPFFRCACAQGW 1367
            +G S         + C C  G+
Sbjct: 2708 YGCSNTEGG----YLCGCPPGY 2725



 Score =  439 bits (1129), Expect = e-122
 Identities = 472/1702 (27%), Positives = 664/1702 (39%), Gaps = 381/1702 (22%)

Query: 43   CLD-----GSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHS-GPCAGRGV-CQS 95
            C+D      +PC NG  C   P     C C  G+  +R   +  C     C   GV C++
Sbjct: 533  CIDVDECTSNPCTNGD-CVNTPG-SYYCKCHAGF--QRTPTKQACIDIDECIQNGVLCKN 588

Query: 96   SVVAGT-ARFSCRCPRGFR----GPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGY 150
                 T   F C C  GF     G +C   D C ++       C +  DG F C C PG+
Sbjct: 589  GRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMC-INEDGSFKCICKPGF 647

Query: 151  ----QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAG------------------ 188
                 GR C +DVDEC+    C +G  C+N+ GSFRC CP G                  
Sbjct: 648  VLAPNGRYC-TDVDECQTPGICMNGH-CINSEGSFRCDCPPGLAVGMDGRVCVDTHMRST 705

Query: 189  -------------YTGPL------CENP----AVPCAPSPCRNG----GTCRQSGDLTYD 221
                         + G +      C NP      PC P P +N     G C     +T D
Sbjct: 706  CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVD 765

Query: 222  CACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC----PPEWTGQFCTEDVDE 277
                 G +   C ++ D C        G C +   +Y C C     P+ +G+ C  D+DE
Sbjct: 766  -----GRDINECALDPDICAN------GICENLRGSYRCNCNSGYEPDASGRNCI-DIDE 813

Query: 278  CQLQPNACHNGGTCFNTLGGHSCVCVNGWT----GESCSQNIDDCATAVCFHGATCHDRV 333
            C +    C NG  C NT G +SC C  G+      E+C ++I++C +  C +GA C + +
Sbjct: 814  CLVNRLLCDNG-LCRNTPGSYSCTCPPGYVFRTETETC-EDINECESNPCVNGA-CRNNL 870

Query: 334  ASFYCACPMGK----TGLLC--HLDDACVSNPCHEDAICDTNPVNGRAI----------- 376
             SF C C  G     TGL+C   L   C  N   +D+ C+ N +NG  +           
Sbjct: 871  GSFNCECSPGSKLSSTGLICIDSLKGTCWLNI--QDSRCEVN-INGATLKSECCATLGAA 927

Query: 377  -----------CTCPPGFTG--GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
                         CP G     G   +DV+EC +    C + GRCVN++GSF C+C  G 
Sbjct: 928  WGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGL 986

Query: 424  T----GPRC-ETDVNECLSGPCRNQATCLDRI-GQF---TCICMAGFT-GTYCEVDIDEC 473
            T    G  C +  + +C      ++  C+  + G+F    C C  G   GT CE    EC
Sbjct: 987  TLDGTGRVCLDIRMEQCYLK--WDEDECIHPVPGKFRMDACCCAVGAAWGTECE----EC 1040

Query: 474  QSSPCVNGGVCKDRVNGFSCTCPSG---------FSGSTCQLDVDECASTP--CRNGAKC 522
                       K     +   CP G          +G     D++EC + P  C  G KC
Sbjct: 1041 P----------KPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG-KC 1089

Query: 523  VDQPDGYECRCAEGFEGTLCDRN---VDDC--SPDPCHHGRCVDGIASFSCACAPGYTG- 576
             +    ++CRC  GF   + +RN   +D+C  SPD C  G CV+   SF C C  GY   
Sbjct: 1090 RNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESG 1149

Query: 577  ----TRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCA- 625
                  C   +DEC   P  CR GG C++    + C CP G     +  +C V+I++C+ 
Sbjct: 1150 FMMMKNC-MDIDECERNPLLCR-GGTCVNTEGSFQCDCPLGHELSPSREDC-VDINECSL 1206

Query: 626  -SNPCTFGVCRDGINRYDCVCQPGFTGPLCN---VEINECASSPCGEGGSCVDGENGFRC 681
              N C  G C + I  Y C C PG+          +I+EC     G    C + E  + C
Sbjct: 1207 SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC 1266

Query: 682  LCPPGSLPPLCLPPSHPCAH--------EPCSHGICYDAPGGFRCVCEPGWSGPRCSQS- 732
             C  G      +P    CA         + C  G C + PG +RC+C  G+      ++ 
Sbjct: 1267 SCSEGYA---LMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323

Query: 733  LARDACE--SQPCRAGGTCSSDGMGFHCTCPPGVQGRQ----CELLSPCT--PNPCEHGG 784
            +  + C+  S  C  G  C +    F C C  G   ++    C  +  C    + C+   
Sbjct: 1324 IDVNECDLNSNICMFG-ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHA 1382

Query: 785  RCESAPGQLPVCSCPQGW--QGPRCQQDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGY 841
             C + PG    CSC +GW   G +C  D+DEC+ G   C  +  C N  GS+ C C  G+
Sbjct: 1383 SCLNIPGSFK-CSCREGWIGNGIKCI-DLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440

Query: 842  TGPSCD-QDINDCDPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDEC-LSNP 895
            TG      D+++C  N  L   G C +  G++ C C  GF   +  R  +D+DEC   N 
Sbjct: 1441 TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI 1500

Query: 896  CGPGTCTDHVASFTCTCPPGYG----GFHCEQDLPDCS-PSSCFNGGTCVDGVNSFSCLC 950
            C  GTC +    F C C  GY     G +C  D+ +C+ P +C NG  CV+    + C C
Sbjct: 1501 CVFGTCNNLPGMFHCICDDGYELDRTGGNCT-DIDECADPINCVNG-LCVNTPGRYECNC 1558

Query: 951  RPGY----TGAHC-QHEADPCLSR--PCLHGGVCSAAHPGF---RCTCLESFTGPQCQTL 1000
             P +    TG  C  +    C  +  P   G +      G    R +C        C   
Sbjct: 1559 PPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC-------CSLG 1611

Query: 1001 VDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL-----PCREAAAQIGVRLEQLC 1055
              W +  PC+       T  Y LCP G   R   I  +      C+E        L  LC
Sbjct: 1612 KAWGN--PCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQE--------LPGLC 1661

Query: 1056 QAGGQCVDEDSSHYCVCPEGRTGSH----CEQEVDPCLAQPCQHG-GTCRGYMGGYMCEC 1110
            Q GG C++   S  C CP+G   S     CE ++D C A P   G GTC   +G Y C C
Sbjct: 1662 Q-GGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGTCYNTLGNYTCIC 1719

Query: 1111 LP---------------------GYNGDNCEDD---------------VDECASQPCQHG 1134
             P                      YNG  CE++               V +  ++PC+  
Sbjct: 1720 PPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPC 1779

Query: 1135 GSCIDLVARYLCSCPPG---TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRC 1191
             +      + +C   PG    +     ++ D+C   P + +      NG C++ +G FRC
Sbjct: 1780 PTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICA------NGVCINQIGSFRC 1833

Query: 1192 TCPPGYTG----LRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS-GPRCQTV 1246
             CP G++     L CE DI+EC +G        DC+  PG  +RC C AGF   P    V
Sbjct: 1834 ECPTGFSYNDLLLVCE-DIDECSNGDNLCQRNADCINSPGS-YRCECAAGFKLSPNGACV 1891

Query: 1247 -LSPCESQP--CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARS---CRELQCPV 1300
              + C   P  C HG  C    G     ++ C C   F   + + +      C    C  
Sbjct: 1892 DRNECLEIPNVCSHG-LCVDLQG-----SYQCICHNGFKASQDQTMCMDVDECERHPCGN 1945

Query: 1301 GVPCQQTPRGPRCACPPG---------LSGPSCRSFPGSPPGASNASCAAAPCLHG-GSC 1350
            G  C+ T     C C PG         L    C SF G         C    C +  GS 
Sbjct: 1946 GT-CKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQV-------CRNGRCFNEIGS- 1996

Query: 1351 RPAPLAPFFRCACAQGWT----GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRC----D 1402
                    F+C C +G+     G  C        V+    C    CQ   G  RC     
Sbjct: 1997 --------FKCLCNEGYELTPDGKNCIDTNEC--VALPGSCSPGTCQNLEGSFRCICPPG 2046

Query: 1403 RECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGG 1462
             E  S  C  D  +C     DP   C    C       +C   C     L DN       
Sbjct: 2047 YEVKSENC-IDINECD---EDP-NICLFGSCTNTPGGFQC--LCPPGFVLSDN------- 2092

Query: 1463 RERTCNPVYEKYCADHFADGRC 1484
              R C    + +C  +F +G+C
Sbjct: 2093 -GRRCFDTRQSFCFTNFENGKC 2113



 Score =  422 bits (1085), Expect = e-117
 Identities = 453/1713 (26%), Positives = 643/1713 (37%), Gaps = 339/1713 (19%)

Query: 36   PGAAAPP----CLDGSPCANGGRCTQ----LPSREAACLCPPGWV----GERC---QLED 80
            PG    P    C D   C   G C             C CPPG      G  C    +  
Sbjct: 645  PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704

Query: 81   PCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGAR------- 133
             C+ G    +GVC         +  C C      PD    +PC   P  + A        
Sbjct: 705  TCYGG--IKKGVCVRPFPGAVTKSECCCAN----PDYGFGEPCQPCPAKNSAEFHGLCSS 758

Query: 134  -------------CSVGPD-----------GRFLCSCPPGYQ----GRSCRSDVDECRVG 165
                         C++ PD           G + C+C  GY+    GR+C  D+DEC V 
Sbjct: 759  GVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNC-IDIDECLVN 817

Query: 166  EPCRHGGTCLNTPGSFRCQCPAGYT----GPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221
                  G C NTPGS+ C CP GY        CE+    C  +PC NG      G    +
Sbjct: 818  RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCED-INECESNPCVNGACRNNLGSFNCE 876

Query: 222  CA-----------CLPGFEGQNCEVNVDDCPGHRCLNGGTCVD----------GVNTYNC 260
            C+           C+   +G  C +N+ D      +NG T             G     C
Sbjct: 877  CSPGSKLSSTGLICIDSLKG-TCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERC 935

Query: 261  Q----CP---PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313
            +    CP       G  C EDV+EC++ P  C N G C N+ G   C C  G T +   +
Sbjct: 936  ELDTACPRGLARIKGVTC-EDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTGR 993

Query: 314  NIDDCATAVCF----HGATCHDRVASF---YCACPMGKT-GLLCHLDDACVSNPCHE-DA 364
               D     C+         H     F    C C +G   G  C   + C      E + 
Sbjct: 994  VCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC---EECPKPGTKEYET 1050

Query: 365  ICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424
            +C      G          TG    +D++EC      C + G+C NT GSF C+C  G+ 
Sbjct: 1051 LCP----RGAGFANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFKCRCNSGFA 1105

Query: 425  ---GPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGFTGTYCE----VDIDECQSS 476
                 R  TD++EC +S        C++  G F C C  G+   +      +DIDEC+ +
Sbjct: 1106 LDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERN 1165

Query: 477  PCV-NGGVCKDRVNGFSCTCPSGFSGSTCQ---LDVDECASTP--CRNGAKCVDQPDGYE 530
            P +  GG C +    F C CP G   S  +   +D++EC+ +   CRNG KCV+    Y+
Sbjct: 1166 PLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG-KCVNMIGTYQ 1224

Query: 531  CRCAEGFEGTLCDRNVDDCSPDPCHHG----RCVDGIASFSCACAPGYT----GTRCESQ 582
            C C  G++ T   +   D       +G    +C +   S+ C+C+ GY     G  C + 
Sbjct: 1225 CSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-AD 1283

Query: 583  VDECRSQP-CRHGGKCLDLVDKYLCRCPSGTTG-----VNCEVNIDDCASNPCTFGVCRD 636
            +DEC + P    GG+C ++  +Y C C  G           +VN  D  SN C FG C +
Sbjct: 1284 IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECEN 1343

Query: 637  GINRYDCVCQPGFT---GPLCNVEINEC--ASSPCGEGGSCVDGENGFRCLCPPG----S 687
                + C CQ G++   G     +++EC   +  C    SC++    F+C C  G     
Sbjct: 1344 TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNG 1403

Query: 688  LPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG 747
            +  + L       H+   +  C + PG +RC C  G++G   + S   +  E+      G
Sbjct: 1404 IKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENG 1463

Query: 748  TCSSDGMGFHCTC----PPGVQGRQCELLSPCT-PNPCEHGGRCESAPGQLPVCSCPQGW 802
             C +    + C C     P    R C+ +  C+  N C   G C + PG    C C  G+
Sbjct: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVF-GTCNNLPGMFH-CICDDGY 1521

Query: 803  Q----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSC-DQDINDC 853
            +    G  C  D+DECA P  C  +G+C N  G + C C   +    TG  C D  + +C
Sbjct: 1522 ELDRTGGNC-TDIDECADPINC-VNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNC 1579

Query: 854  --DPNPCLNGG-SCQD----GVGSFSCSC------------------------LPGFAGP 882
                 P  +G  SC      GV   SC C                         PG  G 
Sbjct: 1580 YLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639

Query: 883  R------CARDVDECLSNP--CGPGTCTDHVASFTCTCPPGY---GGFHCEQDLPDC--S 929
            R         D+DEC   P  C  G C +   SF C CP GY         +D+ +C   
Sbjct: 1640 RPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699

Query: 930  PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCL 989
            P  C   GTC + + +++C+C P Y   +  H    C+    +    C  ++ G  C   
Sbjct: 1700 PGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHN---CMD---MRKSFCYRSYNGTTCENE 1752

Query: 990  ESFTGPQ----CQTLVDWCSRQPCQNGGRCVQTG-----AYCLCPPGW-----SGRLCDI 1035
              F   +    C   V     +PC+    C   G       C   PG+     +G+  DI
Sbjct: 1753 LPFNVTKRMCCCTYNVGKAWNKPCE---PCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809

Query: 1036 RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH----CEQEVDPCL-- 1089
                C+E        +  +C A G C+++  S  C CP G + +     CE ++D C   
Sbjct: 1810 DE--CKE--------IPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCE-DIDECSNG 1857

Query: 1090 AQPCQHGGTCRGYMGGYMCECLPGY--NGDNCEDDVDECASQP--CQHGGSCIDLVARYL 1145
               CQ    C    G Y CEC  G+  + +    D +EC   P  C H G C+DL   Y 
Sbjct: 1858 DNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH-GLCVDLQGSYQ 1916

Query: 1146 CSCPPGTLG----VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY--TG 1199
            C C  G        +C ++ D+C   P          NGTC + VG + C C PG+  T 
Sbjct: 1917 CICHNGFKASQDQTMC-MDVDECERHP--------CGNGTCKNTVGSYNCLCYPGFELTH 1967

Query: 1200 LRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRCQTVLSPCESQPC 1255
                 DI+EC S          C  +  G F+CLC+ G+     G  C    + C + P 
Sbjct: 1968 NNDCLDIDECSSFFGQVCRNGRCFNEI-GSFKCLCNEGYELTPDGKNCIDT-NECVALP- 2024

Query: 1256 QHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQ--------CPVGVPCQQT 1307
               G C P        +F C C      P  E  + +C ++         C  G  C  T
Sbjct: 2025 ---GSCSPGTCQNLEGSFRCICP-----PGYEVKSENCIDINECDEDPNICLFG-SCTNT 2075

Query: 1308 PRGPRCACPPG--LSGPSCRSFPGSP----PGASNASCAAAPCLHGGSCRPAPLAPFFRC 1361
            P G +C CPPG  LS    R F            N  C+     +             +C
Sbjct: 2076 PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKA---------KC 2126

Query: 1362 ACA----QGWTGPRCEAPAAAPEVSEEPRCPRA-ACQAKRGDQRCD-REC-NSPGCGWDG 1414
             C+    +GW  P CE      EV+ +  CP          D R D  EC  SPG     
Sbjct: 2127 CCSKMPGEGWGDP-CELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGI-CSN 2184

Query: 1415 GDCSLSVGDPWRQCEALQCWRL-FNNSRCDPACSSPACLYDNFDCHAGG--RERTCNPV- 1470
            G C  + G    +CE    + L +   RC           D  +C  G      TC  V 
Sbjct: 2185 GQCINTDGS--FRCECPMGYNLDYTGVRC----------VDTDECSIGNPCGNGTCTNVI 2232

Query: 1471 --YEKYCADHFADGRCDQGCNTEECGWDGLDCA 1501
              +E  C + F  G      +  EC  + L CA
Sbjct: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCA 2265



 Score =  397 bits (1019), Expect = e-110
 Identities = 421/1534 (27%), Positives = 586/1534 (38%), Gaps = 339/1534 (22%)

Query: 60   SREAACLCPPGWVGERCQLED--PCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
            SR   C C  G +   C  +    C S  C   G C            C+C +G+ G  C
Sbjct: 125  SRPNMCTCSSGQISSTCGSKSIQQC-SVRCMNGGTCADD--------HCQCQKGYIGTYC 175

Query: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG--------EPCR 169
                P   + C +G RC +GP+    C+C  G+ G  C  D    R G        + C+
Sbjct: 176  G--QPVCENGCQNGGRC-IGPNR---CACVYGFTGPQCERDY---RTGPCFTQVNNQMCQ 226

Query: 170  HGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE 229
               T +    +  C       G  CE    P  P PCR G               +P   
Sbjct: 227  GQLTGIVCTKTLCCATIGRAWGHPCE--MCPAQPQPCRRG--------------FIPNIR 270

Query: 230  GQNCEVNVDDC---PGHRCLNGGTCVDGVNTYNCQCPP----EWTGQFCTEDVDECQLQP 282
               C+ +VD+C   PG     GG C++ V ++ C+CP       T Q C ED+DEC + P
Sbjct: 271  TGACQ-DVDECQAIPG--ICQGGNCINTVGSFECRCPAGHKQSETTQKC-EDIDECSIIP 326

Query: 283  NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT-------CHDRVAS 335
              C  G  C NT+G + CVC  G+   +      D  T +CF G            R+  
Sbjct: 327  GICETG-ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTK 385

Query: 336  FYCACPMGKTGLLCHLDDACVSNPCHE-DAIC-DTNPVNG-RAICTCPPGFTGG------ 386
              C C  G+   +  + +AC      E   +C D  P+ G        PG TGG      
Sbjct: 386  MQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPS 445

Query: 387  --------------------------------------------ACDQDVDECSIGANPC 402
                                                          +Q +D C   AN C
Sbjct: 446  GNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLC 505

Query: 403  EHLGRCVNTQGSFLCQCGRGY---TGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459
             + GRC+ T  S+ C+C  GY       C  DV+EC S PC N   C++  G + C C A
Sbjct: 506  LN-GRCIPTVSSYRCECNMGYKQDANGDC-IDVDECTSNPCTN-GDCVNTPGSYYCKCHA 562

Query: 460  GFTGTYCE---VDIDEC-QSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDEC 511
            GF  T  +   +DIDEC Q+      G C +    F C C +GF     G  C +D DEC
Sbjct: 563  GFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNC-VDHDEC 621

Query: 512  AST-PCRNGAKCVDQPDGYECRCAEGF----EGTLCDRNVDDC-SPDPCHHGRCVDGIAS 565
             +T  C NG  C+++   ++C C  GF     G  C  +VD+C +P  C +G C++   S
Sbjct: 622  TTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMNGHCINSEGS 679

Query: 566  FSCACAPGY-TGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCP---SGTTGVNCEVNI 621
            F C C PG   G      VD      C +GG     + K +C  P   + T    C  N 
Sbjct: 680  FRCDCPPGLAVGMDGRVCVDTHMRSTC-YGG-----IKKGVCVRPFPGAVTKSECCCANP 733

Query: 622  DDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSP--CGEGGSCVDGENGF 679
            D     PC     ++    +  +C  G    +   +INECA  P  C   G C +    +
Sbjct: 734  DYGFGEPCQPCPAKNSA-EFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSY 791

Query: 680  RCLCPPGSLPPL----CLPPSHPCAHE-PCSHGICYDAPGGFRCVCEPGWSGPRCSQSLA 734
            RC C  G  P      C+       +   C +G+C + PG + C C PG+   R      
Sbjct: 792  RCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVF-RTETETC 850

Query: 735  RD--ACESQPCRAGGTCSSDGMGFHCTCPPG---------------------VQGRQCE- 770
             D   CES PC   G C ++   F+C C PG                     +Q  +CE 
Sbjct: 851  EDINECESNPC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEV 909

Query: 771  ------LLSPCTP-------NPCEHGGRCESAPGQLPVCSCPQGW---QGPRCQQDVDEC 814
                  L S C         +PCE   RCE         +CP+G    +G  C +DV+EC
Sbjct: 910  NINGATLKSECCATLGAAWGSPCE---RCELD------TACPRGLARIKGVTC-EDVNEC 959

Query: 815  -AGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSC-DQDINDC----DPNPCLN---- 860
               P  C P+G C N  GSF C C  G     TG  C D  +  C    D + C++    
Sbjct: 960  EVFPGVC-PNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPG 1018

Query: 861  ---------------GGSCQD----GVGSFSCSCLPG---------FAGPRCARDVDECL 892
                           G  C++    G   +   C  G           G    +D++EC 
Sbjct: 1019 KFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECK 1078

Query: 893  SNP--CGPGTCTDHVASFTCTCPPGYGGFHCEQ---DLPDC--SPSSCFNGGTCVDGVNS 945
            + P  C  G C + + SF C C  G+     E+   D+ +C  SP  C   G CV+   S
Sbjct: 1079 AFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLC-GSGICVNTPGS 1137

Query: 946  FSCLCRPGYTGA-----HCQHEADPCLSRPCL-HGGVCSAAHPGFRCTC-LESFTGPQCQ 998
            F C C  GY        +C  + D C   P L  GG C      F+C C L     P  +
Sbjct: 1138 FECECFEGYESGFMMMKNCM-DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRE 1196

Query: 999  TLVD--WCSRQP--CQNGGRCVQTGAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQ 1053
              VD   CS     C+NG      G Y C C PG+       ++ P R+    I    E 
Sbjct: 1197 DCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGY-------QATPDRQGCTDID---EC 1246

Query: 1054 LCQAGG---QCVDEDSSHYCVCPEGRT----GSHCEQEVDPCLAQP--CQHGGTCRGYMG 1104
            +   GG   QC + + S+ C C EG      G  C  ++D C   P  C  GG C    G
Sbjct: 1247 MIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENNPDICD-GGQCTNIPG 1304

Query: 1105 GYMCECLPGYNGD----NCEDDVDEC--ASQPCQHGGSCIDLVARYLCSCPPG---TLGV 1155
             Y C C  G+        C  DV+EC   S  C   G C +    ++C C  G     G 
Sbjct: 1305 EYRCLCYDGFMASMDMKTC-IDVNECDLNSNICMF-GECENTKGSFICHCQLGYSVKKGT 1362

Query: 1156 LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY--TGLRCEADINECRSGA 1213
                + D+C  G        C  + +C+++ G F+C+C  G+   G++C  D++EC +G 
Sbjct: 1363 TGCTDVDECEIG-----AHNCDMHASCLNIPGSFKCSCREGWIGNGIKC-IDLDECSNGT 1416

Query: 1214 CHAAHTRDCLQDPGGGFRCLCHAGFSGP--RCQTVLSPCESQPCQHGGQCRPSPGPGGGL 1271
               +    C+  P G +RC C  GF+G    C  V    E+      GQC   PG     
Sbjct: 1417 HQCSINAQCVNTP-GSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPG----- 1470

Query: 1272 TFTCHCAQPFWGPRCERVARSCRELQ-------CPVGVPCQQTPRGPRCACPPGL----S 1320
             + C C   F  P  +  +RSC+++        C  G  C   P    C C  G     +
Sbjct: 1471 AYRCECEMGF-TPASD--SRSCQDIDECSFQNICVFGT-CNNLPGMFHCICDDGYELDRT 1526

Query: 1321 GPSCRSFP--GSPPGASNASCAAAPCLHGGSCRP 1352
            G +C        P    N  C   P  +  +C P
Sbjct: 1527 GGNCTDIDECADPINCVNGLCVNTPGRYECNCPP 1560



 Score =  373 bits (957), Expect = e-102
 Identities = 459/1782 (25%), Positives = 657/1782 (36%), Gaps = 499/1782 (28%)

Query: 51   NGGRCTQLPSREAACLCPPGWVGERCQLEDP---------CHSGPCAGRG-VCQSSVVAG 100
            +G RC      +   +C  G V  RC  E P         C  G C G G + ++  V G
Sbjct: 354  DGSRCID----QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRG 409

Query: 101  TARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARC--------SVGPDGRFLCSCP----- 147
            +  +   C  G   P   +P    S P   G             GP G      P     
Sbjct: 410  SEEYRRLCMDGL--PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF 467

Query: 148  -PGYQGRSC---------------RSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTG 191
             PG  G                     +D C+        G C+ T  S+RC+C  GY  
Sbjct: 468  SPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQ 527

Query: 192  PLCEN--PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE----GQNCEVNVDDC--PGH 243
                +      C  +PC NG      G  +Y C C  GF+     Q C +++D+C   G 
Sbjct: 528  DANGDCIDVDECTSNPCTNGDCVNTPG--SYYCKCHAGFQRTPTKQAC-IDIDECIQNGV 584

Query: 244  RCLNGGTCVDGVNTYNCQCPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
             C N G CV+   ++ C C   +     G+ C  D DEC    N C N G C N  G   
Sbjct: 585  LCKN-GRCVNTDGSFQCICNAGFELTTDGKNCV-DHDEC-TTTNMCLN-GMCINEDGSFK 640

Query: 300  CVCVNGW----TGESCSQNIDDCAT-AVCFHGATCHDRVASFYCACP----MGKTGLLC- 349
            C+C  G+     G  C+ ++D+C T  +C +G  C +   SF C CP    +G  G +C 
Sbjct: 641  CICKPGFVLAPNGRYCT-DVDECQTPGICMNG-HCINSEGSFRCDCPPGLAVGMDGRVCV 698

Query: 350  --HLDDACVS------------NPCHEDAICDTNPVNG----------------RAICTC 379
              H+   C                  +   C  NP  G                  +C+ 
Sbjct: 699  DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758

Query: 380  PPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNEC 435
              G T     +D++EC++  + C + G C N +GS+ C C  GY    +G  C  D++EC
Sbjct: 759  GVGIT--VDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNC-IDIDEC 814

Query: 436  LSGP--CRNQATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNG 490
            L     C N   C +  G ++C C  G+   T T    DI+EC+S+PCVN G C++ +  
Sbjct: 815  LVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVN-GACRNNLGS 872

Query: 491  FSCTCPSGFSGS------------TCQLDVDE----------------CASTPCRNGAKC 522
            F+C C  G   S            TC L++ +                CA+     G+ C
Sbjct: 873  FNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC 932

Query: 523  VDQPDGYECRCAEG---FEGTLCDRNVDDCS--PDPCHHGRCVDGIASFSCACAPGYT-- 575
              +    +  C  G    +G  C+ +V++C   P  C +GRCV+   SF C C  G T  
Sbjct: 933  --ERCELDTACPRGLARIKGVTCE-DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLD 989

Query: 576  GT----------RCESQVDE----------------CRSQPCRHGGKCLDL----VDKYL 605
            GT          +C  + DE                C +     G +C +       +Y 
Sbjct: 990  GTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYE 1049

Query: 606  CRCPSGT---------TGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFTGPL- 653
              CP G          TG     +I++C + P  CT+G CR+ I  + C C  GF   + 
Sbjct: 1050 TLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDME 1109

Query: 654  ---CNVEINECASSP--CG----------------------------------------- 667
               C  +I+EC  SP  CG                                         
Sbjct: 1110 ERNC-TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLL 1168

Query: 668  -EGGSCVDGENGFRCLCPPG-SLPPL---CLPPSH-PCAHEPCSHGICYDAPGGFRCVCE 721
              GG+CV+ E  F+C CP G  L P    C+  +    +   C +G C +  G ++C C 
Sbjct: 1169 CRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCN 1228

Query: 722  PGWSGPRCSQSLAR-DACESQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPCT 776
            PG+      Q     D C          C++    + C+C  G      GR C  +  C 
Sbjct: 1229 PGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECE 1288

Query: 777  PNP--CEHGGRCESAPGQLPVCSCPQGWQGPRCQQ---DVDECAGPAPCGPHGICTNLAG 831
             NP  C+ GG+C + PG+   C C  G+      +   DV+EC   +     G C N  G
Sbjct: 1289 NNPDICD-GGQCTNIPGEYR-CLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKG 1346

Query: 832  SFSCTCHGGYT---GPSCDQDINDCD--PNPCLNGGSCQDGVGSFSCSCLPGFAGP--RC 884
            SF C C  GY+   G +   D+++C+   + C    SC +  GSF CSC  G+ G   +C
Sbjct: 1347 SFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1406

Query: 885  ARDVDECL--SNPCG-PGTCTDHVASFTCTCPPGY--GGFHCEQDLPDCSPS-SCFNGGT 938
              D+DEC   ++ C     C +   S+ C C  G+   GF C  D+ +C+ + +    G 
Sbjct: 1407 I-DLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC-SDVDECAENINLCENGQ 1464

Query: 939  CVDGVNSFSCLCRPGYTGA----HCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF-- 992
            C++   ++ C C  G+T A     CQ + D C  +     G C+     F C C + +  
Sbjct: 1465 CLNVPGAYRCECEMGFTPASDSRSCQ-DIDECSFQNICVFGTCNNLPGMFHCICDDGYEL 1523

Query: 993  --TGPQCQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGW----SGRLC-DIR------- 1036
              TG  C  + +      C N G CV T G Y C CPP +    +G  C D R       
Sbjct: 1524 DRTGGNCTDIDECADPINCVN-GLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLK 1582

Query: 1037 -------SLPCREAAAQIGVRLEQLCQAGGQ--------CVDEDSS-HYCVCPEG----- 1075
                   SL C      +GV     C + G+        C   +S+ +Y +CP G     
Sbjct: 1583 FGPRGDGSLSCNTEIG-VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRP 1641

Query: 1076 RTGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQP 1130
               +   +++D C   P  CQ GG C    G + CEC  GY         +D+DEC + P
Sbjct: 1642 NPITIILEDIDECQELPGLCQ-GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHP 1700

Query: 1131 CQHG-GSCIDLVARYLCSCPPGTL---------------------GVLCEINE------- 1161
               G G+C + +  Y C CPP  +                     G  CE NE       
Sbjct: 1701 GVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCE-NELPFNVTK 1759

Query: 1162 --------------DDCGPGP---PLDSGPRC---------LHNGTCVDL---------- 1185
                            C P P     D    C         +H G  VD+          
Sbjct: 1760 RMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC 1819

Query: 1186 --------VGGFRCTCPPGYTG----LRCEADINECRSGACHAAHTRDCLQDPG------ 1227
                    +G FRC CP G++     L CE DI+EC +G        DC+  PG      
Sbjct: 1820 ANGVCINQIGSFRCECPTGFSYNDLLLVCE-DIDECSNGDNLCQRNADCINSPGSYRCEC 1878

Query: 1228 ----------------------------------GGFRCLCHAGFSGPRCQTV---LSPC 1250
                                              G ++C+CH GF   + QT+   +  C
Sbjct: 1879 AAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC 1938

Query: 1251 ESQPCQHGGQCRPSPG-------PGGGLTFTCHC-----AQPFWGPRCE--RVARSCREL 1296
            E  PC + G C+ + G       PG  LT    C        F+G  C   R        
Sbjct: 1939 ERHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSF 1997

Query: 1297 QCPVGVPCQQTPRGPRC-------ACPPGLSGPSCRSFPGS-----PPGASNAS------ 1338
            +C      + TP G  C       A P   S  +C++  GS     PPG    S      
Sbjct: 1998 KCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDI 2057

Query: 1339 --CAAAP--CLHGGSCRPAPLAPFFRCACAQGW----TGPRC 1372
              C   P  CL  GSC   P    F+C C  G+     G RC
Sbjct: 2058 NECDEDPNICLF-GSCTNTPGG--FQCLCPPGFVLSDNGRRC 2096



 Score =  365 bits (937), Expect = e-100
 Identities = 412/1541 (26%), Positives = 583/1541 (37%), Gaps = 317/1541 (20%)

Query: 185  CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNC-EVNVDDCPGH 243
            CP   T P      VP   + C +G   R +      C C  G     C   ++  C   
Sbjct: 98   CPGWKTLPGGNQCIVPICRNSCGDGFCSRPNM-----CTCSSGQISSTCGSKSIQQC-SV 151

Query: 244  RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCV 303
            RC+NGGTC D     +CQC   + G +C + V E     N C NGG C   +G + C CV
Sbjct: 152  RCMNGGTCADD----HCQCQKGYIGTYCGQPVCE-----NGCQNGGRC---IGPNRCACV 199

Query: 304  NGWTGESCSQNIDDCATAVCF---HGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360
             G+TG  C +   D  T  CF   +   C  ++    C     KT L C        +PC
Sbjct: 200  YGFTGPQCER---DYRTGPCFTQVNNQMCQGQLTGIVCT----KT-LCCATIGRAWGHPC 251

Query: 361  HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG 420
                +C   P   R      P    GAC QDVDEC      C+  G C+NT GSF C+C 
Sbjct: 252  E---MCPAQPQPCRRGFI--PNIRTGAC-QDVDECQAIPGICQG-GNCINTVGSFECRCP 304

Query: 421  RGY----TGPRCETDVNEC--LSGPCRNQATCLDRIGQFTCICMAGFT----GTYCEVDI 470
             G+    T  +CE D++EC  + G C     C + +G + C+C  G+     G+ C    
Sbjct: 305  AGHKQSETTQKCE-DIDECSIIPGICET-GECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362

Query: 471  DECQSSPCVNGGVCKD---RVNGFSCTCPSGFSGS------TCQLDVDECASTPCRNGAK 521
                 S  VNG   ++   R+    C C  G           C +   E     C +G  
Sbjct: 363  TGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLP 422

Query: 522  CVDQPDGYECRCA-EGFEGTLCDRNVDDCSPD-------PCHHGRC--VDGIASFSCACA 571
                P     R    G  G     N +   P        P  +G    V G    +    
Sbjct: 423  MGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQG 482

Query: 572  PGYTGTRCESQ-VDECRSQP--CRHGGKCLDLVDKYLCRCPSG---TTGVNCEVNIDDCA 625
            P  TG    +Q +D C+     C +G +C+  V  Y C C  G       +C +++D+C 
Sbjct: 483  PIITGLTILNQTIDICKHHANLCLNG-RCIPTVSSYRCECNMGYKQDANGDC-IDVDECT 540

Query: 626  SNPCTFGVCRDGINRYDCVCQPGF----TGPLCNVEINEC-ASSPCGEGGSCVDGENGFR 680
            SNPCT G C +    Y C C  GF    T   C ++I+EC  +    + G CV+ +  F+
Sbjct: 541  SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQAC-IDIDECIQNGVLCKNGRCVNTDGSFQ 599

Query: 681  CLCPPG----SLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGW----SGPRCSQS 732
            C+C  G    +    C+          C +G+C +  G F+C+C+PG+    +G  C+  
Sbjct: 600  CICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDV 659

Query: 733  LARDACESQPCRAGGTCSSDGMGFHCTCPP----GVQGRQC---ELLSPCTPNPCEHGGR 785
               D C++      G C +    F C CPP    G+ GR C    + S C     + G  
Sbjct: 660  ---DECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCY-GGIKKGVC 715

Query: 786  CESAPGQLP----VCSCPQGWQGPRCQ------------------------QDVDECAGP 817
                PG +      C+ P    G  CQ                        +D++ECA  
Sbjct: 716  VRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALD 775

Query: 818  APCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNPCL-NGGSCQDGVGSFS 872
                 +GIC NL GS+ C C+ GY    +G +C  DI++C  N  L + G C++  GS+S
Sbjct: 776  PDICANGICENLRGSYRCNCNSGYEPDASGRNC-IDIDECLVNRLLCDNGLCRNTPGSYS 834

Query: 873  CSCLPGF---AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPG----YGGFHCEQDL 925
            C+C PG+          D++EC SNPC  G C +++ SF C C PG      G  C   L
Sbjct: 835  CTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSL 894

Query: 926  PDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFR 985
                       GTC   +N     C     GA  + E   C +     G  C        
Sbjct: 895  K----------GTC--WLNIQDSRCEVNINGATLKSEC--CATLGAAWGSPCERCELDTA 940

Query: 986  C-TCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQT--GAYCLCPPG----WSGRLC-DI 1035
            C   L    G  C+  V+ C   P  C N GRCV +    +C CP G     +GR+C DI
Sbjct: 941  CPRGLARIKGVTCED-VNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTGRVCLDI 998

Query: 1036 RSLPC------REAAAQI--GVRLEQLCQAGG--------QCVDEDSSHY-CVCPEGR-- 1076
            R   C       E    +    R++  C A G        +C    +  Y  +CP G   
Sbjct: 999  RMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058

Query: 1077 -------TGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGYNGD----NCED-- 1121
                   TG    ++++ C A P  C + G CR  +G + C C  G+  D    NC D  
Sbjct: 1059 ANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFKCRCNSGFALDMEERNCTDID 1117

Query: 1122 ----------------------------------------DVDECASQPCQ-HGGSCIDL 1140
                                                    D+DEC   P    GG+C++ 
Sbjct: 1118 ECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNT 1177

Query: 1141 VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL 1200
               + C CP   LG     + +DC              NG CV+++G ++C+C PGY   
Sbjct: 1178 EGSFQCDCP---LGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQAT 1234

Query: 1201 RCE---ADINEC--RSGACHAAHTRDCLQDPGGGFRCLCHAGFS----GPRCQTVLSPCE 1251
                   DI+EC   +G C    T     +  G + C C  G++    G  C  +   CE
Sbjct: 1235 PDRQGCTDIDECMIMNGGCDTQCT-----NSEGSYECSCSEGYALMPDGRSCADI-DECE 1288

Query: 1252 SQP--CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQ-----CPVGVPC 1304
            + P  C  GGQC   PG      + C C   F      +      E       C  G  C
Sbjct: 1289 NNPDICD-GGQCTNIPG-----EYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFG-EC 1341

Query: 1305 QQTPRGPRCACPPGLS----GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR 1360
            + T     C C  G S       C        GA N    A+ CL+        +   F+
Sbjct: 1342 ENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHAS-CLN--------IPGSFK 1392

Query: 1361 CACAQGWTGPRCEAPAAAPEVSEEPRCP-RAACQAKRGDQRCDRECNSPGCGWDGGDCS- 1418
            C+C +GW G   +        +   +C   A C    G  RC     S G   DG  CS 
Sbjct: 1393 CSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRC---ACSEGFTGDGFTCSD 1449

Query: 1419 -LSVGDPWRQCEALQCWRLFNNSRCD------PACSSPA------CLYDNFDCHAGGRER 1465
                 +    CE  QC  +    RC+      PA  S +      C + N  C  G    
Sbjct: 1450 VDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI-CVFG---- 1504

Query: 1466 TCN---PVYEKYCADHFADGRCDQGC-NTEECGWDGLDCAS 1502
            TCN    ++   C D +   R    C + +EC  D ++C +
Sbjct: 1505 TCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPINCVN 1544



 Score =  166 bits (420), Expect = 2e-40
 Identities = 140/491 (28%), Positives = 206/491 (41%), Gaps = 103/491 (20%)

Query: 65   CLCPPGWV----GERCQLEDPCHSGPCAGRGVCQSS-VVAGTARFSCRCPRGFR----GP 115
            C+CPPG      GE C  E+ C + P    G+C++   V     + C C  GF+    G 
Sbjct: 2321 CICPPGMARRPDGEGCVDENECRTKP----GICENGRCVNIIGSYRCECNEGFQSSSSGT 2376

Query: 116  DCS-----------LPDPCL-----------SSPCAHGAR--------CSVGPDGRFLCS 145
            +C            L   C            S  C  G R        C +    ++   
Sbjct: 2377 ECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI 2436

Query: 146  CPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP---CA 202
            CP G    +   D+DEC+V       G C+NT GSFRC C  GYT  +     +    C+
Sbjct: 2437 CPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECS 2496

Query: 203  PSPCRNGGTCRQSGDLTYDCACLPGF----EGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258
             SP      C+ + + +Y C+C  G+    +G+ C+ ++D+C   +      CV+ +  +
Sbjct: 2497 QSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGF 2554

Query: 259  NCQCPPEWTGQFCTEDVD--ECQLQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCS 312
             C+CPP +T Q  T  +D  EC  QP+ C   G C NT G  SC C  G+    TG +C 
Sbjct: 2555 TCKCPPGFT-QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC- 2612

Query: 313  QNIDDC-ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACV-SNPCHEDAICDTN 369
            +++D+C     C HG  C + +  + C CP    G + H   + CV  N C     C + 
Sbjct: 2613 EDVDECDGNHRCQHG--CQNILGGYRCGCPQ---GYIQHYQWNQCVDENECSNPNACGSA 2667

Query: 370  P---VNGRAICTCPPGFT----GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 422
                  G   C CP GF+      AC  DV+ECS   NPC +   C NT+G +LC C  G
Sbjct: 2668 SCYNTLGSYKCACPSGFSFDQFSSAC-HDVNECSSSKNPCNY--GCSNTEGGYLCGCPPG 2724

Query: 423  YTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT-GTYCEVDIDECQSSPCVNG 481
            Y                         R+GQ  C+   GF  G Y  +D +  + +     
Sbjct: 2725 YY------------------------RVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE 2760

Query: 482  GVCKDRVNGFS 492
               + ++NG+S
Sbjct: 2761 ACYECKINGYS 2771



 Score =  132 bits (333), Expect = 3e-30
 Identities = 203/780 (26%), Positives = 266/780 (34%), Gaps = 197/780 (25%)

Query: 753  GMGFHCTCPPGVQ----GRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRC- 807
            G  FH  C PG +    G QC  + P   N C  G  C S P    +C+C  G     C 
Sbjct: 90   GSRFHSYCCPGWKTLPGGNQC--IVPICRNSCGDGF-C-SRPN---MCTCSSGQISSTCG 142

Query: 808  QQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDG 867
             + + +C+    C   G C +      C C  GY G  C Q +  C+ N C NGG C   
Sbjct: 143  SKSIQQCS--VRCMNGGTCAD----DHCQCQKGYIGTYCGQPV--CE-NGCQNGGRC--- 190

Query: 868  VGSFSCSCLPGFAGPRCARDVDECLSNPC----GPGTCTDHVASFTCT---CPPGYG--- 917
            +G   C+C+ GF GP+C RD     + PC        C   +    CT   C    G   
Sbjct: 191  IGPNRCACVYGFTGPQCERDYR---TGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW 247

Query: 918  GFHCE----------------------QDLPDCS--PSSCFNGGTCVDGVNSFSCLCRPG 953
            G  CE                      QD+ +C   P  C  GG C++ V SF C C  G
Sbjct: 248  GHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGIC-QGGNCINTVGSFECRCPAG 306

Query: 954  Y----TGAHCQHEADPCLSRPCL-HGGVCSAAHPGFRCTCLESF-TGPQCQTLVDWCSRQ 1007
            +    T   C+ + D C   P +   G CS     + C C   + T       +D  +  
Sbjct: 307  HKQSETTQKCE-DIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGM 365

Query: 1008 PCQNG---GRCVQ------TGAYCLCPPGWSGRLCDIRSLPCREAAAQIG-VRLEQLCQA 1057
             C +G   GRC Q      T   C C P   GR   I ++P  EA    G     +LC  
Sbjct: 366  -CFSGLVNGRCAQELPGRMTKMQCCCEP---GRCWGIGTIP--EACPVRGSEEYRRLCMD 419

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGY-MGGYMCECLPGYNG 1116
            G              P G                     G   GY  GG     +PG NG
Sbjct: 420  G-------------LPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNG 466

Query: 1117 -----------------------------DNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
                                         D C+   + C +      G CI  V+ Y C 
Sbjct: 467  FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLN------GRCIPTVSSYRCE 520

Query: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLRCE 1203
            C    +G   + N  DC       S P    NG CV+  G + C C  G+    T   C 
Sbjct: 521  C---NMGYKQDAN-GDCIDVDECTSNP--CTNGDCVNTPGSYYCKCHAGFQRTPTKQAC- 573

Query: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRCQTVLSPCESQPCQHGG 1259
             DI+EC        + R C+ +  G F+C+C+AGF     G  C      C +      G
Sbjct: 574  IDIDECIQNGVLCKNGR-CV-NTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNG 630

Query: 1260 QCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCP---VGVPCQQTPRGPRCACP 1316
             C    G     +F C C   F      R      E Q P   +   C  +    RC CP
Sbjct: 631  MCINEDG-----SFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCP 685

Query: 1317 PGLS-----------------------GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPA 1353
            PGL+                       G   R FPG+    S   CA      G  C+P 
Sbjct: 686  PGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVT-KSECCCANPDYGFGEPCQPC 744

Query: 1354 PL--APFFRCACAQG----WTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNS 1407
            P   +  F   C+ G      G      A  P++     C    C+  RG  RC+  CNS
Sbjct: 745  PAKNSAEFHGLCSSGVGITVDGRDINECALDPDI-----CANGICENLRGSYRCN--CNS 797



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 111/414 (26%), Positives = 151/414 (36%), Gaps = 85/414 (20%)

Query: 976  VCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDI 1035
            VC +    + C   ++  G   Q +V  C R  C +G  C +    C C  G     C  
Sbjct: 88   VCGSRFHSYCCPGWKTLPGGN-QCIVPIC-RNSCGDGF-CSRPNM-CTCSSGQISSTCGS 143

Query: 1036 RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQH 1095
            +S+       Q  VR    C  GG C D+    +C C +G  G++C Q   P     CQ+
Sbjct: 144  KSIQ------QCSVR----CMNGGTCADD----HCQCQKGYIGTYCGQ---PVCENGCQN 186

Query: 1096 GGTCRGYMGGYMCECLPGYNGDNCEDDV------DECASQPCQHGGSCIDLVARYLCS-- 1147
            GG C   +G   C C+ G+ G  CE D        +  +Q CQ   + I       C+  
Sbjct: 187  GGRC---IGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATI 243

Query: 1148 ----------CP----PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
                      CP    P   G +  I    C       + P     G C++ VG F C C
Sbjct: 244  GRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRC 303

Query: 1194 PPGY----TGLRCEADINECR--SGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRC 1243
            P G+    T  +CE DI+EC    G C    T +C    G  F C+C  G+     G RC
Sbjct: 304  PAGHKQSETTQKCE-DIDECSIIPGIC---ETGECSNTVGSYF-CVCPRGYVTSTDGSRC 358

Query: 1244 QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQC-PVGV 1302
                        Q  G C      G        CAQ   G R  ++   C   +C  +G 
Sbjct: 359  ID----------QRTGMCFSGLVNG-------RCAQELPG-RMTKMQCCCEPGRCWGIGT 400

Query: 1303 PCQQTP-RGP---RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
              +  P RG    R  C  GL         GS PG +  +   AP  +G    P
Sbjct: 401  IPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGN-GFAPSGNGNGYGP 453



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 41/158 (25%), Positives = 54/158 (34%), Gaps = 33/158 (20%)

Query: 1220 RDCLQDP---GGGFRCLCHAGFSG-PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275
            +D L+ P   G  F   C  G+   P     + P     C  G   RP+          C
Sbjct: 80   QDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPN---------MC 130

Query: 1276 HCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGAS 1335
             C+       C   +     ++C  G  C        C C  G  G  C       P   
Sbjct: 131  TCSSGQISSTCGSKSIQQCSVRCMNGGTCADD----HCQCQKGYIGTYC-----GQPVCE 181

Query: 1336 NASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
            N       C +GG C    + P  RCAC  G+TGP+CE
Sbjct: 182  NG------CQNGGRC----IGPN-RCACVYGFTGPQCE 208


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  453 bits (1165), Expect = e-126
 Identities = 248/727 (34%), Positives = 329/727 (45%), Gaps = 73/727 (10%)

Query: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
           C  G+ G +C            HG  C+V  +    C C  G+QGR C    DEC     
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGG-CTVPGE----CRCSYGWQGRFC----DECVPYPG 281

Query: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPS-PCRNGGTCRQSGDLTYDCACLP 226
           C HG +C+     ++C C   + G LC+     C    PC NGGTC  +    Y C C  
Sbjct: 282 CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337

Query: 227 GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH 286
           G+ G+NCE     C  + C NGG+C +  + + C CP  W+G  C  D+DEC   P  C 
Sbjct: 338 GYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP--CA 395

Query: 287 NGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTG 346
            GGTC + + G  C+C   W G +C  +++DC    C HG TC D V  + C CP G  G
Sbjct: 396 AGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGG 454

Query: 347 LLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHL 405
             C L+ D C S+PCH   +C+   +     C CP GF+G  C+ DVD C    +PC + 
Sbjct: 455 RHCELERDECASSPCHSGGLCE--DLADGFHCHCPQGFSGPLCEVDVDLCE--PSPCRNG 510

Query: 406 GRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCR-----------------------N 442
            RC N +G + C C   + G  C      C  G CR                        
Sbjct: 511 ARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGP 570

Query: 443 QATCLDRI-GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSG 501
              C+ +  G F+CIC +GFTGTYC  +ID+C   PC NGG C D V+ F C CPSG+ G
Sbjct: 571 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEG 630

Query: 502 STCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH-GRCV 560
             C  + ++C   PC +  +C D  + + C C +G++G  C      C    C + G C 
Sbjct: 631 ELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY 690

Query: 561 DGIASFSCACAPGYTGTRCE-SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619
           D   +F CAC PG+ G+ C  ++   C   PC +GG C+     + C C  G  G  C  
Sbjct: 691 DSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTH 750

Query: 620 NIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENG 678
           N +DC   PC   G+C DG+N + C C PGF GP C + I+EC SSPC  G +CVD  NG
Sbjct: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 810

Query: 679 FRCLCPPGSLPP----------LCLPPSHPCAH-----EPCSHGICYDAPGGFRCVCEPG 723
           +RC CPPG   P           C     P  H     E C+   C D     R  C   
Sbjct: 811 YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSKV 866

Query: 724 WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP----GVQGRQCELLSPCTPNP 779
           W G +      +    S  C  G  C     G  C  PP    G  G +    +PC P  
Sbjct: 867 WCGWKPCLLAGQPEALSAQCPLGQRCLEKAPG-QCLRPPCEAWGECGAEEPPSTPCLPRS 925

Query: 780 CEHGGRC 786
                 C
Sbjct: 926 GHLDNNC 932



 Score =  449 bits (1156), Expect = e-125
 Identities = 251/676 (37%), Positives = 315/676 (46%), Gaps = 63/676 (9%)

Query: 377  CTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECL 436
            C C  G+ G  CD    EC +    C H G CV     + C C   + G  C+ D+N C 
Sbjct: 262  CRCSYGWQGRFCD----EC-VPYPGCVH-GSCVEP---WQCNCETNWGGLLCDKDLNYCG 312

Query: 437  SG-PCRNQATCLD-RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT 494
            S  PC N  TC++    Q+ C C  G++G  CE     C S+PC NGG C +  +GF C 
Sbjct: 313  SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECH 372

Query: 495  CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC 554
            CPSG+SG TC LD+DECAS PC  G  CVDQ DG+EC C E + G  C  +V+DC     
Sbjct: 373  CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQ 432

Query: 555  HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG 614
            H G C D +  + C C  G+ G  CE + DEC S PC  GG C DL D + C CP G +G
Sbjct: 433  HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG 492

Query: 615  VNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINEC------------ 661
              CEV++D C  +PC  G  C +    Y C C   F G  C+V    C            
Sbjct: 493  PLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 552

Query: 662  -----------ASSPCGEGGSCVDGENG-FRCLCPPGSLPPLCLPPSHPCAHEPCSH-GI 708
                       AS  CG  G CV    G F C+C  G     C      C  +PC + G 
Sbjct: 553  SDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 612

Query: 709  CYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQ 768
            C D    FRC C  GW G  C  +   + C   PC + G C      F+C C  G +G+ 
Sbjct: 613  CIDEVDAFRCFCPSGWEGELCDTN--PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKT 670

Query: 769  CELLS-PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827
            C      C    C +GG C  + G    C+CP GW+G  C    +    P PC   G C 
Sbjct: 671  CHSREFQCDAYTCSNGGTCYDS-GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV 729

Query: 828  NLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARD 887
                SFSC C  G+ G +C  + NDC+P PC NGG C DGV  F C C PGFAGP C  +
Sbjct: 730  GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 789

Query: 888  VDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSF 946
            +DEC S+PC  G TC D +  + C+CPPG  G  C++ +      SC++ GT     +S+
Sbjct: 790  IDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSW 847

Query: 947  -----SCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSA--AHPGFRCTCLESFTGPQCQT 999
                 SC C  G            C  +PCL  G   A  A       CLE   G     
Sbjct: 848  VEDCNSCRCLDGRRDC----SKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ---- 899

Query: 1000 LVDWCSRQPCQNGGRC 1015
                C R PC+  G C
Sbjct: 900  ----CLRPPCEAWGEC 911



 Score =  403 bits (1036), Expect = e-112
 Identities = 232/718 (32%), Positives = 311/718 (43%), Gaps = 133/718 (18%)

Query: 797  SCPQGWQGPRCQQDV-----------------------------DECAGPAP-------- 819
            +C  GW G  C++ V                             DEC  P P        
Sbjct: 230  ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECV-PYPGCVHGSCV 288

Query: 820  ----------------------CGPHGICTN-------LAGSFSCTCHGGYTGPSCDQDI 850
                                  CG H  CTN           + CTC  GY+G +C++  
Sbjct: 289  EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348

Query: 851  NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP-GTCTDHVASFT 909
            + C  NPC NGGSC +    F C C  G++GP CA D+DEC SNPC   GTC D V  F 
Sbjct: 349  HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408

Query: 910  CTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSR 969
            C CP  + G  C+ D+ DC    C +GGTC D VN + C+C  G+ G HC+ E D C S 
Sbjct: 409  CICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS 467

Query: 970  PCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCLCPPG 1027
            PC  GG+C     GF C C + F+GP C+  VD C   PC+NG RC  ++   YC CP  
Sbjct: 468  PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527

Query: 1028 WSGRLCDIRSLPCREAAAQI-------------GVRLEQLCQAGGQCVDEDSSHY-CVCP 1073
            + G+ C +   PC   A ++             G     +C   G+CV +   ++ C+C 
Sbjct: 528  FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 587

Query: 1074 EGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQH 1133
             G TG++C + +D CL QPC++GGTC   +  + C C  G+ G+ C+ + ++C   PC  
Sbjct: 588  SGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 647

Query: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
             G C DLV  + C+C  G  G  C   E  C           C + GTC D    FRC C
Sbjct: 648  RGRCYDLVNDFYCACDDGWKGKTCHSREFQC-------DAYTCSNGGTCYDSGDTFRCAC 700

Query: 1194 PPGYTGLRCE-ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            PPG+ G  C  A  + C    C    T  C+   G  F C+C  G+ G  C    + C  
Sbjct: 701  PPGWKGSTCAVAKNSSCLPNPCVNGGT--CV-GSGASFSCICRDGWEGRTCTHNTNDCNP 757

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
             PC +GG C       G   F C CA  F GP C      C+   C  G  C     G R
Sbjct: 758  LPCYNGGIC-----VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812

Query: 1313 CACPPGLSGPSCRSFPG-----------SPPGAS-NASCAAAPCLHGGSCRPAPLAPFFR 1360
            C+CPPG +GP C+   G            P G+S    C +  CL G            R
Sbjct: 813  CSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG------------R 860

Query: 1361 CACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGC-GWDGGDC 1417
              C++ W G +    A  PE +   +CP      +R  ++   +C  P C  W  G+C
Sbjct: 861  RDCSKVWCGWKPCLLAGQPE-ALSAQCP----LGQRCLEKAPGQCLRPPCEAW--GEC 911



 Score =  391 bits (1004), Expect = e-108
 Identities = 224/631 (35%), Positives = 294/631 (46%), Gaps = 64/631 (10%)

Query: 43  CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQ-LEDPCHSGPCAGRGVCQSSVVAGT 101
           C    PC NGG C      +  C CP G+ G  C+  E  C S PCA  G C   V +G 
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH-EVPSG- 368

Query: 102 ARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
             F C CP G+ GP C+L  D C S+PCA G  C    DG F C CP  + G +C+ DV+
Sbjct: 369 --FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQWVGATCQLDVN 425

Query: 161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTY 220
           +CR    C+HGGTC +    ++C CP G+ G  CE     CA SPC +GG C    D  +
Sbjct: 426 DCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD-GF 482

Query: 221 DCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC-- 278
            C C  GF G  CEV+VD C    C NG  C +    Y C CP ++ G+ C+   + C  
Sbjct: 483 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPG 542

Query: 279 -------------------QLQPNACHNGGTCFNTLGGH-SCVCVNGWTGESCSQNIDDC 318
                                    C   G C +  GG+ SC+C +G+TG  C +NIDDC
Sbjct: 543 GACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 602

Query: 319 ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAIC 377
               C +G TC D V +F C CP G  G LC  + + C+ +PCH    C  + VN    C
Sbjct: 603 LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC-YDLVND-FYC 660

Query: 378 TCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN-ECL 436
            C  G+ G  C     +C   A  C + G C ++  +F C C  G+ G  C    N  CL
Sbjct: 661 ACDDGWKGKTCHSREFQCD--AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCL 718

Query: 437 SGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCP 496
             PC N  TC+     F+CIC  G+ G  C  + ++C   PC NGG+C D VN F C C 
Sbjct: 719 PNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECA 778

Query: 497 SGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVD---DC---- 549
            GF+G  C++++DEC S+PC  GA CVD+ +GY C C  G  G  C   +     C    
Sbjct: 779 PGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRG 838

Query: 550 SPDP--------CHHGRCVDGIASFS---CACAPGYTGTRCESQVDECRSQPCRHGGKCL 598
           +P P        C+  RC+DG    S   C   P     +      E  S  C  G +CL
Sbjct: 839 TPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQ-----PEALSAQCPLGQRCL 893

Query: 599 DLVDKYLCRCPSGTTGVNCEVNIDDCASNPC 629
           +       R P    G   E   ++  S PC
Sbjct: 894 EKAPGQCLRPPCEAWG---ECGAEEPPSTPC 921



 Score =  338 bits (868), Expect = 3e-92
 Identities = 229/745 (30%), Positives = 309/745 (41%), Gaps = 96/745 (12%)

Query: 806  RCQQDVDECAGPAPCGPHGICTNLAGSFSC------TCHGGYTGPSCDQDINDCDPNPCL 859
            RC ++         C P     +  G ++C       C  G+ G  C + +     N  L
Sbjct: 197  RCDENYYSATCNKFCRPRN---DFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCN-LL 252

Query: 860  NGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP-CGPGTCTDHVASFTCTCPPGYGG 918
            +GG    G     C C  G+ G  C    DEC+  P C  G+C   V  + C C   +GG
Sbjct: 253  HGGCTVPG----ECRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGG 301

Query: 919  FHCEQDLPDC-SPSSCFNGGTCVDGV-NSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGV 976
              C++DL  C S   C NGGTC++   + + C C  GY+G +C+     C S PC +GG 
Sbjct: 302  LLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGS 361

Query: 977  CSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLCPPGWSGRLCD 1034
            C     GF C C   ++GP C   +D C+  PC  GG CV    G  C+CP  W G  C 
Sbjct: 362  CHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQ 421

Query: 1035 IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQ 1094
            +    CR             CQ GG C D  + + CVCP G  G HCE E D C + PC 
Sbjct: 422  LDVNDCRGQ-----------CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCH 470

Query: 1095 HGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLG 1154
             GG C     G+ C C  G++G  CE DVD C   PC++G  C +L   Y C+CP    G
Sbjct: 471  SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530

Query: 1155 VLCEINEDDC---------------GPG-PPLDSGPRCLHNGTCVDLVGG-FRCTCPPGY 1197
              C +  + C               GPG P   +   C  +G CV   GG F C C  G+
Sbjct: 531  KNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF 590

Query: 1198 TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257
            TG  C  +I++C    C    T  C+ D    FRC C +G+ G  C T  + C   PC  
Sbjct: 591  TGTYCHENIDDCLGQPCRNGGT--CI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 647

Query: 1258 GGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPP 1317
             G+C           F C C   + G  C      C    C  G  C  +    RCACPP
Sbjct: 648  RGRCYDLVN-----DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702

Query: 1318 GLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAA 1377
            G  G +C         A N+SC   PC++GG+C  +  +  F C C  GW G  C     
Sbjct: 703  GWKGSTCAV-------AKNSSCLPNPCVNGGTCVGSGAS--FSCICRDGWEGRTC--THN 751

Query: 1378 APEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA------L 1431
              + +  P      C       RC  EC     G+ G DC +++     +C++       
Sbjct: 752  TNDCNPLPCYNGGICVDGVNWFRC--EC---APGFAGPDCRINID----ECQSSPCAYGA 802

Query: 1432 QCWRLFNNSRCD--PACSSPAC---LYDNFDCHAGGRERTCNPVYEKYC-ADHFADGRCD 1485
             C    N  RC   P  + P C   +     C + G        + + C +    DGR D
Sbjct: 803  TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 862

Query: 1486 QGCNTEECGWDGLDCASEVPALLAR 1510
              C+   CGW     A +  AL A+
Sbjct: 863  --CSKVWCGWKPCLLAGQPEALSAQ 885



 Score =  207 bits (527), Expect = 1e-52
 Identities = 110/287 (38%), Positives = 143/287 (49%), Gaps = 18/287 (6%)

Query: 34  AGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGV 92
           AGPG   P       C   GRC   P    +C+C  G+ G  C    D C   PC   G 
Sbjct: 555 AGPGM--PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 612

Query: 93  CQSSVVAGTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ 151
           C   V A    F C CP G+ G  C   P+ CL  PC    RC       F C+C  G++
Sbjct: 613 CIDEVDA----FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC-YDLVNDFYCACDDGWK 667

Query: 152 GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC---ENPAVPCAPSPCRN 208
           G++C S   +C     C +GGTC ++  +FRC CP G+ G  C   +N +  C P+PC N
Sbjct: 668 GKTCHSREFQCD-AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS--CLPNPCVN 724

Query: 209 GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
           GGTC  SG  ++ C C  G+EG+ C  N +DC    C NGG CVDGVN + C+C P + G
Sbjct: 725 GGTCVGSG-ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAG 783

Query: 269 QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI 315
             C  ++DECQ  P  C  G TC + + G+ C C  G  G  C + I
Sbjct: 784 PDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  446 bits (1148), Expect = e-125
 Identities = 493/1765 (27%), Positives = 665/1765 (37%), Gaps = 424/1765 (24%)

Query: 55   CTQLPSREAACLCPPG-------WVGERCQLED----PCHSGPCAGRGVCQSSVVAGTAR 103
            C    S E A LCP G       ++  R   +D        G C   G C+++V      
Sbjct: 954  CPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCT-HGTCRNTV----GS 1008

Query: 104  FSCRCPRGF----RGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQG-----RS 154
            F C C  GF    +  +C+  D C  SP   G    V   G F C C PGY+      ++
Sbjct: 1009 FHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN 1068

Query: 155  CRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT----GPLCENPAVPCAPSP--CRN 208
            C  DVDEC        GGTC NT GS++CQCP G+     G  CE+    C+ S   C +
Sbjct: 1069 CM-DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACED-IDECSLSDGLCPH 1126

Query: 209  GGTCRQSGDLTYDCACLPGFEG----QNCEVNVDDCPGHRCLNGGTCVDGVNT---YNCQ 261
            G      G   + C+C  GF+     Q C V++++C   R  NGG  V  +NT   Y C 
Sbjct: 1127 GQCVNVIG--AFQCSCHAGFQSTPDRQGC-VDINEC---RVQNGGCDVHCINTEGSYRCS 1180

Query: 262  CPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ---N 314
            C   ++    G+ C  DVDEC+  P  C  G  C N  GGH C+C +G+      +   +
Sbjct: 1181 CGQGYSLMPDGRACA-DVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVD 1238

Query: 315  IDDCATA--VCFHGATCHDRVASFYCACPMG----KTGLLCHLDDACV--SNPCHEDAIC 366
            +D+C     +C HG  C +   SF C C +G    K    C   D C    + C   A C
Sbjct: 1239 VDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASC 1297

Query: 367  DTNPVNGRAICTCPPGFTGGACD-QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTG 425
               P  G   C C PG+ G   +  D+DEC    + C   G C+N  GS+ C C +G+ G
Sbjct: 1298 LNIP--GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAG 1355

Query: 426  P-----------------------------RCET--------------DVNECLSGPCRN 442
                                          RCE               DV+EC  G    
Sbjct: 1356 DGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCA 1415

Query: 443  QATCLDRIGQFTCICMAGFT----GTYCEVDIDECQSSP-CVNGGVCKDRVNGFSCTCPS 497
              +C +  G F CIC  G+     G  C  DI+EC     C+NG VC +    + C+CP 
Sbjct: 1416 FGSCENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCING-VCINTPGSYLCSCPQ 1473

Query: 498  GF--------------------------SGSTCQLDVDE-------CASTPCRNGAKCVD 524
             F                          SG +C  ++         C S     G  C  
Sbjct: 1474 DFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL 1533

Query: 525  QPDG----YECRC--AEGFEG---TLCDRNVDDCS--PDPCHHGRCVDGIASFSCACAPG 573
             P      Y   C   EGF+    T+   ++D+C   P  C  G CV+   SF C C PG
Sbjct: 1534 CPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPG 1593

Query: 574  Y---TGTRCESQVDECRSQPCRHG-GKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC 629
            Y     TR    +DEC +     G G C + +  Y C CP+    VN   N  D   + C
Sbjct: 1594 YHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVC 1653

Query: 630  TFGVCRDGINRYDCVCQPGFTGPL------CNVEINECASSPCGEGGSCVDGENGFRCLC 683
                       Y+  CQ      +      C+  I +  + PC    + +  +  ++ LC
Sbjct: 1654 --------FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPD--YQILC 1703

Query: 684  PPGSLPPLCLPPSHP--------CAHEP--CSHGICYDAPGGFRCVCEPGWSGPRCSQSL 733
              G+  P  L   H         C   P  C++GIC +  G FRC C  G++      + 
Sbjct: 1704 --GNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLAC 1761

Query: 734  AR-DACESQ--PCRAGGTCSSDGMGFHCTCPPGVQ---GRQCELLSPCT--PNPCEHGGR 785
               D C S+  PC+    C +    + C C  G +   G  C   + C   PN C HG  
Sbjct: 1762 EDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD- 1820

Query: 786  CESAPGQLPVCSCPQGWQGPRCQ---QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT 842
            C    G   +C C +G+Q    Q    D+DEC    PCG +G C N+ GS++C C  G+ 
Sbjct: 1821 CMDTEGSY-MCLCHRGFQASADQTLCMDIDEC-DRQPCG-NGTCKNIIGSYNCLCFPGFV 1877

Query: 843  GPSCDQDINDCDPNPCLNG-----GSCQDGVGSFSCSCLPGFA----GPRCARDVDECLS 893
              + + D  D D    L G     G C +  GSF C C  GF     G  C  D +ECLS
Sbjct: 1878 -VTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV-DTNECLS 1935

Query: 894  --NPCGPGTCTDHVASFTCTCPPGYG--GFHCEQDLPDCS--PSSCFNGGTCVDGVNSFS 947
                C PGTC +   SF C CPPG+     HC  D+ +CS  P+ C  G TC +   SF 
Sbjct: 1936 LAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCI-DIDECSEEPNLCLFG-TCTNSPGSFQ 1993

Query: 948  CLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ 1007
            CLC PG+  +   H    C          C       +C+  ++F   + +     CS++
Sbjct: 1994 CLCPPGFVLSDNGHR---CFDT---RQSFCFTRFEAGKCSVPKAFNTTKTRCC---CSKR 2044

Query: 1008 PCQNGGR----CVQTGAYC---LCP------PGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054
            P +  G     C Q G+     LCP      PG      D+      E A   GV     
Sbjct: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVN-----ECAENPGV----- 2094

Query: 1055 CQAGGQCVDEDSSHYCVCPEGR----TGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCEC 1110
            C   G CV+ D S  C CP G     TG +C    +  +  PC  G TC   +GG+ C C
Sbjct: 2095 C-TNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQG-TCTNVIGGFECAC 2152

Query: 1111 LPGYNGD---NCEDDVDECASQPCQHGGSCIDLVARYLCSCPPG-TL---GVLCEINEDD 1163
              G+       CED +DEC+  P      C +    YLC+CP G TL   G +C  + D+
Sbjct: 2153 ADGFEPGLMMTCED-IDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDE 2210

Query: 1164 CGPG---------------------------PPLDSGPRCLH------------NGTCVD 1184
            C  G                           P   SG  C              NG CV+
Sbjct: 2211 CADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVN 2270

Query: 1185 LVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGG------FRCLCHAGF 1238
              G FRC C  G+       + ++ R G C A   +   +             C C  G 
Sbjct: 2271 TAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGR 2330

Query: 1239 S-GPRCQTVLSPCES---QPCQHG----------------------GQCRPSPGPGGGLT 1272
              GPRC+    P  S   + C HG                      G+C  S G     +
Sbjct: 2331 GWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLG-----S 2385

Query: 1273 FTCHCAQPFWGPRCERVA----RSCRELQCPVGVPCQQTPRGPRCACPPGL----SGPSC 1324
            F CHC Q  + P            C ++  P    C+ T     C+CP G      G +C
Sbjct: 2386 FRCHC-QAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444

Query: 1325 RSFP----------------------GSPPGAS--------NASCAA--APCLHGGSCRP 1352
            +                           PPG +        N  C+A   PC   G C  
Sbjct: 2445 KDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHN 2504

Query: 1353 APLAPFFRCACAQGWT----GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCD-RECNS 1407
             P +  FRC C QG+T    G  CE      E     RC +  CQ + G  RC   +  +
Sbjct: 2505 TPGS--FRCECHQGFTLVSSGHGCE---DVNECDGPHRC-QHGCQNQLGGYRCSCPQGFT 2558

Query: 1408 PGCGW----DGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGR 1463
                W    D  +C+LS       C +  C       RC   C S      +FD   GG 
Sbjct: 2559 QHSQWAQCVDENECALSP----PTCGSASCRNTLGGFRC--VCPSGF----DFDQALGG- 2607

Query: 1464 ERTCNPVYEKYCADHFADGRCDQGC 1488
               C  V E  CA     G C   C
Sbjct: 2608 ---CQEVDE--CAGR--RGPCSYSC 2625



 Score =  444 bits (1143), Expect = e-124
 Identities = 442/1508 (29%), Positives = 593/1508 (39%), Gaps = 300/1508 (19%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVG----ERCQLEDPCHSGP--CAGRGVCQSS 96
            C +     + G CT +P     CLC  G++       C   D C   P  C   G C+++
Sbjct: 1200 CEENPRVCDQGHCTNMPGGHR-CLCYDGFMATPDMRTCVDVDECDLNPHICL-HGDCENT 1257

Query: 97   VVAGTARFSCRCPRGFR----GPDCSLPDPCL--SSPCAHGARCSVGPDGRFLCSCPPGY 150
                   F C C  G+        CS  D C      C   A C   P G F C C PG+
Sbjct: 1258 ----KGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP-GSFSCRCLPGW 1312

Query: 151  QGRSCRS-DVDECRVGEP-CRHGGTCLNTPGSFRCQCPAGYTGP--LCENPAVPCAPSP- 205
             G      D+DEC   E  C   G CLN PGS+RC C  G+ G    CE+    CA +  
Sbjct: 1313 VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRD-ECAENVD 1371

Query: 206  -CRNGGTCRQSGDLTYDCACLPGF---EGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQ 261
             C NG      G   Y C C  GF   E      +VD+C        G+C +    + C 
Sbjct: 1372 LCDNGQCLNAPGG--YRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCI 1429

Query: 262  CPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDD 317
            C   +     G  CT D++EC   P  C NG  C NT G + C C   +          D
Sbjct: 1430 CNGGYELDRGGGNCT-DINECA-DPVNCING-VCINTPGSYLCSCPQDFELNPSGVGCVD 1486

Query: 318  CATAVCF--------HGATCHDRV------ASFYCA-----------CPMGKTG---LLC 349
                 CF         G +C   +      AS  C+           CPM  T     LC
Sbjct: 1487 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLC 1546

Query: 350  HLDDACVSN----------PCHE-DAIC---DTNPVNGRAICTCPPGF---TGGACDQDV 392
               +    N           C E   +C   D     G   C CPPG+         +D+
Sbjct: 1547 PGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI 1606

Query: 393  DECSIGANPCEHLGRCVNTQGSFLCQCGRGYT----GPRCE-------------TDVNEC 435
            DECS  +  C   G C NT G++ C C   Y     G  C              T  NE 
Sbjct: 1607 DECSTHSGICGP-GTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL 1665

Query: 436  LSGPCRNQATCLDRIGQ----------------FTCICMAGFTGTYCEV------DIDEC 473
                 R    C   IGQ                +  +C     G   ++      DIDEC
Sbjct: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725

Query: 474  QSSP--CVNGGVCKDRVNGFSCTCPSGFSGSTCQL---DVDECAS--TPCRNGAKCVDQP 526
               P  C NG +C +++  F C CP+GF+ ++  L   DVDEC S  +PC+  A C++ P
Sbjct: 1726 GEIPAICANG-ICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIP 1784

Query: 527  DGYECRCAEGFE----GTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCES- 581
              Y C+C  G++    G    RN     P+ C HG C+D   S+ C C  G+  +  ++ 
Sbjct: 1785 GSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTL 1844

Query: 582  --QVDECRSQPCRHGGKCLDLVDKYLCRCPSG---TTGVNCEVNIDDCAS---NPCTFGV 633
               +DEC  QPC +G  C +++  Y C C  G   T   +C V+ D+C +     C FG 
Sbjct: 1845 CMDIDECDRQPCGNG-TCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFGH 1902

Query: 634  CRDGINRYDCVCQPGFT----GPLCNVEINECASSPCGEGGSCVDG-----ENGFRCLCP 684
            C +    + C+CQ GF     G  C V+ NEC S      G+C+ G     E  FRC+CP
Sbjct: 1903 CLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSL----AGTCLPGTCQNLEGSFRCICP 1957

Query: 685  PGSLPPL--CLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGW----SGPRC------- 729
            PG       C+     C+ EP  C  G C ++PG F+C+C PG+    +G RC       
Sbjct: 1958 PGFQVQSDHCIDIDE-CSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSF 2016

Query: 730  ----------------SQSLARDACESQPCRAGGT----CSSDGMG-FHCTCP------P 762
                            + +  R  C  +P    G     C  +G   F   CP      P
Sbjct: 2017 CFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVP 2076

Query: 763  GVQGRQCELLSPCTPNP--CEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECAG 816
            G    + E ++ C  NP  C +G  C +  G    C CP G+     G  C  D DEC+ 
Sbjct: 2077 GPDDSR-EDVNECAENPGVCTNGV-CVNTDGSFR-CECPFGYSLDFTGINCV-DTDECSV 2132

Query: 817  PAPCGPHGICTNLAGSFSCTCHGGYTGP---SCDQDINDCDPNPCLNGGSCQDGVGSFSC 873
              PCG  G CTN+ G F C C  G+      +C+ DI++C  NP L    C +  GS+ C
Sbjct: 2133 GHPCG-QGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTEGSYLC 2190

Query: 874  SCLPGFA----GPRCARDVDECLSNP----CGPGTCTDHVASFTCTCPPGY-----GGFH 920
            +C  G+     G  C RDVDEC             C + + +F C CPPG       G  
Sbjct: 2191 TCPAGYTLREDGAMC-RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249

Query: 921  CEQDLPDC--SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCS 978
            C  D  +C   P  C NG  CV+   SF C C  G+  +    E       PC    +  
Sbjct: 2250 CTDD-NECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL-- 2305

Query: 979  AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ-----TGAYC-LCPPGWSGRL 1032
                  +  C    +  +  T  + C       G RC       T AY  LCP G SG  
Sbjct: 2306 ------QTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG-SGYT 2358

Query: 1033 CDIRSLP-CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG----RTGSHCEQEVDP 1087
             + R +  CR         L  LC A G+C++   S  C C  G     T + C  ++D 
Sbjct: 2359 AEGRDVDECR--------MLAHLC-AHGECINSLGSFRCHCQAGYTPDATATTC-LDMDE 2408

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQPCQHGGSCIDLVAR 1143
            C   P      C+   G ++C C  GY    +G  C+D +DEC S+       C++ V  
Sbjct: 2409 CSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD-LDECTSRQHNCQFLCVNTVGA 2467

Query: 1144 YLCSCPPG-TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT---- 1198
            + C CPPG T       + D+C   P    GP C  +G C +  G FRC C  G+T    
Sbjct: 2468 FTCRCPPGFTQHHQACFDNDECSAQP----GP-CGAHGHCHNTPGSFRCECHQGFTLVSS 2522

Query: 1199 GLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSG----PRCQTVLSPCESQP 1254
            G  CE D+NEC  G     H     Q+  GG+RC C  GF+      +C        S P
Sbjct: 2523 GHGCE-DVNEC-DGPHRCQHG---CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPP 2577

Query: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPR----CERVARSCRELQCPVGVPCQQTPRG 1310
                  CR + G      F C C   F   +    C+ V   C   + P    C  TP G
Sbjct: 2578 TCGSASCRNTLGG-----FRCVCPSGFDFDQALGGCQEVDE-CAGRRGPCSYSCANTPGG 2631

Query: 1311 PRCACPPG 1318
              C CP G
Sbjct: 2632 FLCGCPQG 2639



 Score =  425 bits (1093), Expect = e-118
 Identities = 470/1624 (28%), Positives = 622/1624 (38%), Gaps = 335/1624 (20%)

Query: 31   LLLAGPGAAAPPC--LDGSPCA----NGGRCTQLPSREAACLCPPGWVGERCQLEDPCHS 84
            L     G  AP C    GS C+    NGG C     R A+CLC  G+ G  C        
Sbjct: 100  LCTCADGTLAPSCGVSRGSGCSVSCMNGGTC-----RGASCLCQKGYTGTVC-------G 147

Query: 85   GPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP---DPCLSSP----CAH---GARC 134
             P   RG        G  R  C C  GF GP C       PC        C H   G  C
Sbjct: 148  QPICDRGCHNGGRCIGPNR--CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVC 205

Query: 135  S-------VGPDGRFLCSCPPGYQGRSCR------------SDVDECRVGEPCRHGGTCL 175
            +       VG      C   P  Q   CR             DVDEC+       GG+C+
Sbjct: 206  TKALCCATVGRAWGLPCELCPA-QPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264

Query: 176  NTPGSFRCQCPAGY----TGPLCENPAVPCAPSP-------------------CRNGGTC 212
            N  GSF C+CP G+    +   CE+       S                    C + G C
Sbjct: 265  NMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRC 324

Query: 213  RQSGDLTYDCACLPGFEGQN-CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
              +G +   C      E Q  C   +   PGH  L  G    G N      PP       
Sbjct: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG---PP------- 374

Query: 272  TEDVDECQLQPNACHNGGTCFNTLG-GHSCVCVNGWTGESCSQNIDDCA--TAVCFHGAT 328
               +   +L P+     G    +LG G+S +        + +Q ID C   T +C +G  
Sbjct: 375  ---LGPARLNPHGSDARG--IPSLGPGNSNIGT-----ATLNQTIDICRHFTNLCLNG-R 423

Query: 329  CHDRVASFYCACPMGKTGLL---CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF-- 383
            C    +S+ C C +G T  +   C   D C S+PCH     D   + G   C C PGF  
Sbjct: 424  CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQA 480

Query: 384  --TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECLS 437
              T  AC  DVDEC +    C HLGRCVNT+GSF C C  G+     G  C  D NEC +
Sbjct: 481  TPTRQAC-VDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECAT 537

Query: 438  GPCRNQATCLDRIGQFTCICMAGFT----GTYCEVDIDECQS-SPCVNGGVCKDRVNGFS 492
                    CL+  G F+C+C  GF     G YC +DIDECQ+   CVNG  C +    F 
Sbjct: 538  STMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC-MDIDECQTPGICVNGH-CTNTEGSFR 595

Query: 493  CTCPSGFS-GSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTL-----CDRNV 546
            C C  G + G+  ++ VD    + C    +        +  CA  F GT+     C  N 
Sbjct: 596  CQCLGGLAVGTDGRVCVDTHVRSTCYGAIE--------KGSCARPFPGTVTKSECCCANP 647

Query: 547  DDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQP--CRHGGKCLDLVDKY 604
            D    +PC      D  A F   C+ G   T     ++EC   P  C + G C +L   Y
Sbjct: 648  DHGFGEPCQLCPAKDS-AEFQALCSSGLGITTDGRDINECALDPEVCAN-GVCENLRGSY 705

Query: 605  LCRC----PSGTTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGF----TGPLC 654
             C C     +G +G +C  ++D+CA N   C  G C++    Y C C PGF       +C
Sbjct: 706  RCVCNLGYEAGASGKDC-TDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEIC 764

Query: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGS-LPP---LCLPPSH-----PCAHEPCS 705
              +++EC SSPC   G C +    + C C PGS L P    CL  +            C 
Sbjct: 765  K-DVDECLSSPC-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822

Query: 706  HGI---------CYDAPGGFRCVCEPGWSGPRCSQSLAR---------DACESQP-CRAG 746
              +         C      +   CE     P C++  AR         + CES P     
Sbjct: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPN 882

Query: 747  GTCSSDGMGFHCTCPPGV----QGRQC--ELLSPC----TPNPC---------------- 780
            G C +    F C CP G+     GR C    L PC      + C                
Sbjct: 883  GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCS 942

Query: 781  ---EHGGRCESAPG--QLPVCS-CPQG--------WQGPRCQQDVDEC-AGPAPCGPHGI 825
                 G  CE+ P    L   S CP+G          G    +DV+EC   P  C  HG 
Sbjct: 943  IGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC-THGT 1001

Query: 826  CTNLAGSFSCTCHGGYTGPSCDQ---DINDCDPNPCLNG-GSCQDGVGSFSCSCLPGFAG 881
            C N  GSF C C GG+   + ++   DI++C  +P L G G+C +  GSF C C PG+  
Sbjct: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061

Query: 882  ----PRCARDVDECLSNP--CGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDCSPS 931
                 +   DVDEC  +P  C  GTCT+   S+ C CPPG+     G  CE D+ +CS S
Sbjct: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLS 1120

Query: 932  -SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGV---CSAAHPGFRCT 987
                  G CV+ + +F C C  G+     +            +GG    C      +RC+
Sbjct: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCS 1180

Query: 988  CLESFT----GPQCQTLVDWCSRQP--CQNGGRCVQTGAY-CLCPPGWSGRLCDIRSLPC 1040
            C + ++    G  C   VD C   P  C  G      G + CLC  G+         +  
Sbjct: 1181 CGQGYSLMPDGRACAD-VDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDV 1239

Query: 1041 REAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG---RTGSHCEQEVDPCL--AQPCQH 1095
             E      + L       G C +   S  C C  G   R G+    +VD C      C  
Sbjct: 1240 DECDLNPHICLH------GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDS 1293

Query: 1096 GGTCRGYMGGYMCECLPGYNGDNCE-DDVDECASQP--CQHGGSCIDLVARYLCSCPPGT 1152
              +C    G + C CLPG+ GD  E  D+DEC SQ   C   G C+++   Y C+C  G 
Sbjct: 1294 HASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF 1353

Query: 1153 L--GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL---RCEADIN 1207
               G  CE + D+C     L        NG C++  GG+RC C  G+      R   D++
Sbjct: 1354 AGDGFFCE-DRDECAENVDL------CDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD 1406

Query: 1208 ECRSGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRCQTVLSPCESQPCQHGGQCRP 1263
            EC  G   A  + + L    G FRC+C+ G+     G  C T ++ C        G C  
Sbjct: 1407 ECAQGNLCAFGSCENLP---GMFRCICNGGYELDRGGGNC-TDINECADPVNCINGVCIN 1462

Query: 1264 SPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPP---GLS 1320
            +PG     ++ C C Q F             EL  P GV C  T R   C       G S
Sbjct: 1463 TPG-----SYLCSCPQDF-------------ELN-PSGVGCVDT-RAGNCFLETHDRGDS 1502

Query: 1321 GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPE 1380
            G SC +  G   G + ASC                     C+  + W  P CE    A  
Sbjct: 1503 GISCSAEIG--VGVTRASCC--------------------CSLGRAWGNP-CELCPMANT 1539

Query: 1381 VSEEPRCPRA-ACQAKRGDQRCD--RECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLF 1437
                  CP     Q  R     +   EC        GGDC  + G    QCE    + L 
Sbjct: 1540 TEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS--FQCECPPGYHLS 1597

Query: 1438 NNSR 1441
             ++R
Sbjct: 1598 EHTR 1601



 Score =  413 bits (1062), Expect = e-115
 Identities = 454/1593 (28%), Positives = 609/1593 (38%), Gaps = 325/1593 (20%)

Query: 49   CANGGRCTQLPSREAACLCPPGWVGERC--------------QLEDPCHSGPCAGRGVCQ 94
            C +   CT  P     C+  PG    RC               +++   SG     G C 
Sbjct: 447  CIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRC- 505

Query: 95   SSVVAGTARFSCRCPRGFR----GPDCSLPDPCLSSP-CAHGARCSVGPDGRFLCSCPPG 149
               V     F C C  GF     G +C   + C +S  C +G    +  DG F C C PG
Sbjct: 506  ---VNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGV--CLNEDGSFSCLCKPG 560

Query: 150  Y----QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQC----PAGYTGPLCENPAVPC 201
            +     G  C  D+DEC+    C + G C NT GSFRCQC      G  G +C +  V  
Sbjct: 561  FLLAPGGHYC-MDIDECQTPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 618

Query: 202  APSPCRNGGTCRQ--SGDLT-YDCACL---PGFEGQNCEVNVDDCPGH-------RCLNG 248
                    G+C +   G +T  +C C     GF G+ C++    CP          C +G
Sbjct: 619  TCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-GEPCQL----CPAKDSAEFQALCSSG 673

Query: 249  -GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW- 306
             G   DG                   D++EC L P  C N G C N  G + CVC  G+ 
Sbjct: 674  LGITTDG------------------RDINECALDPEVCAN-GVCENLRGSYRCVCNLGYE 714

Query: 307  ---TGESCSQNIDDCA--TAVCFHGATCHDRVASFYCACPMG----KTGLLCHLDDACVS 357
               +G+ C+ ++D+CA  + +C +G  C +   S+ C+CP G    +   +C   D C+S
Sbjct: 715  AGASGKDCT-DVDECALNSLLCDNG-WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLS 772

Query: 358  NPCHEDAICDTNPVNGRAICTCPPG------------FTGGACDQDVDE--CSIGANPCE 403
            +PC    +C    + G   C C PG             T G C   + E  C +      
Sbjct: 773  SPC-VSGVC--RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS 829

Query: 404  HLGRCVNTQGSFL---CQ-------CGRGY---TGPRCETDVNECLS--GPCRNQATCLD 448
                C  T G+     C+       C RG+   TG  C+ DVNEC S  G C N   C++
Sbjct: 830  LRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPN-GRCVN 887

Query: 449  RIGQFTCICMAGF----TGTYC----------EVDIDEC----------QSSPCVNGGV- 483
              G F C C  G     +G  C            D DEC              C  G V 
Sbjct: 888  TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW 947

Query: 484  ------CKDRVN-GFSCTCPSG--------FSGSTCQLDVDECASTP--CRNGAKCVDQP 526
                  C D  +  F+  CP G         SG     DV+EC   P  C +G  C +  
Sbjct: 948  GVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTV 1006

Query: 527  DGYECRCAEGFEGTLCDRN---VDDC--SPDPCHHGRCVDGIASFSCACAPGYTG----- 576
              + C CA GF     +RN   +D+C  SPD C  G CV+   SF C C PGY       
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM 1066

Query: 577  TRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCASNP-- 628
              C   VDEC   P  CR GG C +    Y C+CP G      G  CE +ID+C+ +   
Sbjct: 1067 KNC-MDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLSDGL 1123

Query: 629  CTFGVCRDGINRYDCVCQPGFTGPLCN---VEINECASSPCGEGGSCVDGENGFRCLCPP 685
            C  G C + I  + C C  GF         V+INEC     G    C++ E  +RC C  
Sbjct: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQ 1183

Query: 686  G-SLPP--LCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGW-SGPRCSQSLARDACE 739
            G SL P          C   P  C  G C + PGG RC+C  G+ + P     +  D C+
Sbjct: 1184 GYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECD 1243

Query: 740  SQP-CRAGGTCSSDGMGFHCTCPPGVQGRQ----CELLSPCT--PNPCEHGGRCESAPGQ 792
              P     G C +    F C C  G   R+    C  +  C    + C+    C + PG 
Sbjct: 1244 LNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303

Query: 793  LPVCSCPQGWQGPRCQ-QDVDECAGPA-PCGPHGICTNLAGSFSCTCHGGYTGPS--CDQ 848
               C C  GW G   +  D+DEC      C P G C N+ GS+ CTC  G+ G    C +
Sbjct: 1304 FS-CRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC-E 1361

Query: 849  DINDCDPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECL-SNPCGPGTCTD 903
            D ++C  N  L + G C +  G + C C  GF      R  +DVDEC   N C  G+C +
Sbjct: 1362 DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCEN 1421

Query: 904  HVASFTCTCPPGY----GGFHCEQDLPDCS-PSSCFNGGTCVDGVNSFSCLCRPGY---- 954
                F C C  GY    GG +C  D+ +C+ P +C N G C++   S+ C C   +    
Sbjct: 1422 LPGMFRCICNGGYELDRGGGNC-TDINECADPVNCIN-GVCINTPGSYLCSCPQDFELNP 1479

Query: 955  TGAHC-QHEADPCLSRPCLHG--GVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQN 1011
            +G  C    A  C       G  G+  +A  G         T   C   +      PC+ 
Sbjct: 1480 SGVGCVDTRAGNCFLETHDRGDSGISCSAEIGV------GVTRASCCCSLGRAWGNPCEL 1533

Query: 1012 GGRCVQTGAYCLCPPGWSGRLCDIRSL-----PCREAAAQIGVRLEQLCQAGGQCVDEDS 1066
                  T    LCP G   +   I  +      C+E        L  LCQ GG CV+   
Sbjct: 1534 CPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQE--------LPGLCQ-GGDCVNTFG 1584

Query: 1067 SHYCVCPEG-RTGSHCE--QEVDPCLAQPCQHG-GTCRGYMGGYMCECLPGY----NGDN 1118
            S  C CP G     H    +++D C       G GTC   +G Y C C   Y     G+N
Sbjct: 1585 SFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644

Query: 1119 CEDDVDECASQPCQHGGSCIDLVA----RYLCSCP--------------PGTLG----VL 1156
            C D       +   + G+C + +A    R +C C               P  +     +L
Sbjct: 1645 CMDMRKSVCFR--HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQIL 1702

Query: 1157 CEINE----DDCGPGPPLDSG-----PRCLHNGTCVDLVGGFRCTCPPGYTG----LRCE 1203
            C         D   G PLD       P    NG C++ +G FRC CP G+      L CE
Sbjct: 1703 CGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACE 1762

Query: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS---GPRCQTVLSPCESQP--CQHG 1258
             D++EC S         DC+  P G +RC C  G+    G  C    + C   P  C H 
Sbjct: 1763 -DVDECGSRESPCQQNADCINIP-GSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSH- 1818

Query: 1259 GQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPG 1318
            G C  + G     ++ C C + F     + +     E        C + P G    C   
Sbjct: 1819 GDCMDTEG-----SYMCLCHRGFQASADQTLCMDIDE--------CDRQPCG-NGTCKNI 1864

Query: 1319 LSGPSCRSFPGSPPGASNASCA---AAPCLHGGSCR---PAPLAPFFRCACAQGW----T 1368
            +   +C  FPG      N  C        L G  CR       A  F C C  G+     
Sbjct: 1865 IGSYNCLCFPGFVV-THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1923

Query: 1369 GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRC 1401
            G  C        +S    C    CQ   G  RC
Sbjct: 1924 GKNCVDTNEC--LSLAGTCLPGTCQNLEGSFRC 1954



 Score =  410 bits (1054), Expect = e-114
 Identities = 423/1438 (29%), Positives = 574/1438 (39%), Gaps = 352/1438 (24%)

Query: 40   APPCLDGSPCANGGR-------CTQLPSREAACLCPPGWVGE--RCQLEDPCHSGP--CA 88
            A  C D   C  GG        C  +P    +C C PGWVG+   C   D C S    C+
Sbjct: 1275 ATGCSDVDECEVGGHNCDSHASCLNIPG-SFSCRCLPGWVGDGFECHDLDECVSQEHRCS 1333

Query: 89   GRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPD--------------PCLSSP------- 127
             RG C +  V G+ R  C C +GF G      D               CL++P       
Sbjct: 1334 PRGDCLN--VPGSYR--CTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389

Query: 128  ------------------CAHGARCSVGP----DGRFLCSCPPGYQ----GRSCRSDVDE 161
                              CA G  C+ G      G F C C  GY+    G +C +D++E
Sbjct: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINE 1448

Query: 162  CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPA-VPCAPSPCRN-----------G 209
            C     C +G  C+NTPGS+ C CP  +      NP+ V C  +   N           G
Sbjct: 1449 CADPVNCING-VCINTPGSYLCSCPQDFE----LNPSGVGCVDTRAGNCFLETHDRGDSG 1503

Query: 210  GTCRQS---GDLTYDCACLPGFE-GQNCEV-----------------------------N 236
             +C      G     C C  G   G  CE+                             +
Sbjct: 1504 ISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILED 1563

Query: 237  VDDC---PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT---EDVDECQLQPNACHNGGT 290
            +D+C   PG     GG CV+   ++ C+CPP +     T   ED+DEC      C   GT
Sbjct: 1564 IDECQELPG--LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGIC-GPGT 1620

Query: 291  CFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCF--HGATCHDRVA----SFYCACPMGK 344
            C+NTLG ++CVC   +   +   N  D   +VCF  +  TC + +A       C C    
Sbjct: 1621 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSY-- 1678

Query: 345  TGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTC---PPGF-----TGGACDQDVDECS 396
                 ++  A  + PC     C T P++      C    PGF     TG   D  +DEC 
Sbjct: 1679 -----NIGQAW-NRPCEA---CPT-PISPDYQILCGNQAPGFLTDIHTGKPLD--IDECG 1726

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGYTGPR----CETDVNECLS--GPCRNQATCLDRI 450
                 C + G C+N  GSF C+C  G+        CE DV+EC S   PC+  A C++  
Sbjct: 1727 EIPAICAN-GICINQIGSFRCECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIP 1784

Query: 451  GQFTCICMAGFT---GTYCEVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFSGSTCQ- 505
            G + C C  G+    G  C V  +EC+  P V + G C D    + C C  GF  S  Q 
Sbjct: 1785 GSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQT 1843

Query: 506  --LDVDECASTPCRNGAKCVDQPDGYECRCAEGF----EGTLCDRNVDDCSP---DPCHH 556
              +D+DEC   PC NG  C +    Y C C  GF     G   D   D+C+      C  
Sbjct: 1844 LCMDIDECDRQPCGNGT-CKNIIGSYNCLCFPGFVVTHNGDCVD--FDECTTLVGQVCRF 1900

Query: 557  GRCVDGIASFSCACAPGYT----GTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPS 610
            G C++   SF C C  G+     G  C    +EC S    C  G  C +L   + C CP 
Sbjct: 1901 GHCLNTAGSFHCLCQDGFELTADGKNCVD-TNECLSLAGTCLPG-TCQNLEGSFRCICPP 1958

Query: 611  G--TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFT----GPLC-------- 654
            G      +C ++ID+C+  P  C FG C +    + C+C PGF     G  C        
Sbjct: 1959 GFQVQSDHC-IDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFC 2017

Query: 655  ----------------NVEINECASSPCGEGGS-----CV-DGENGFRCLCP------PG 686
                              +   C S   GEG       C  +G   F+ LCP      PG
Sbjct: 2018 FTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPG 2077

Query: 687  SLPPLCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGWS----GPRCSQSLARDACE- 739
              P       + CA  P  C++G+C +  G FRC C  G+S    G  C  +   D C  
Sbjct: 2078 --PDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDT---DECSV 2132

Query: 740  SQPCRAGGTCSSDGMGFHCTCPPGVQG---RQCELLSPCTPNPCEHGGRCESAPGQLPVC 796
              PC   GTC++   GF C C  G +      CE +  C+ NP     RC +  G   +C
Sbjct: 2133 GHPC-GQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSY-LC 2190

Query: 797  SCPQGW----QGPRCQQDVDECA-GPAPCGPHGI-CTNLAGSFSCTCHGGY-----TGPS 845
            +CP G+     G  C+ DVDECA G   C   G+ C NL G+F+C C  G      +G  
Sbjct: 2191 TCPAGYTLREDGAMCR-DVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249

Query: 846  CDQDINDCDPNP--CLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC------- 896
            C  D N+C   P  C+NG  C +  GSF C C  GF       +  +    PC       
Sbjct: 2250 CTDD-NECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQT 2307

Query: 897  ---GPGTCTDHVASFTCTCPPGYG-GFHCE------------------------QDLPDC 928
                  + ++ V    C C  G G G  CE                        +D+ +C
Sbjct: 2308 MCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDEC 2367

Query: 929  SPSS--CFNGGTCVDGVNSFSCLCRPGYTG---AHCQHEADPC--LSRPCLHGGVCSAAH 981
               +  C +G  C++ + SF C C+ GYT    A    + D C  + +PC    +C    
Sbjct: 2368 RMLAHLCAHG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF--LCKNTK 2424

Query: 982  PGFRCTCLESFT----GPQCQTLVDWCSRQP-CQNGGRCVQT-GAY-CLCPPGWSGRLCD 1034
              F C+C   +     G  C+ L +  SRQ  CQ    CV T GA+ C CPPG++     
Sbjct: 2425 GSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQH--H 2480

Query: 1035 IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRT----GSHCEQEVDPCLA 1090
                   E +AQ G      C A G C +   S  C C +G T    G  CE +V+ C  
Sbjct: 2481 QACFDNDECSAQPGP-----CGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNECDG 2534

Query: 1091 -QPCQHGGTCRGYMGGYMCECLPGYNGDN----CEDDVDECASQPCQHGG-SCIDLVARY 1144
               CQHG  C+  +GGY C C  G+   +    C D+ +ECA  P   G  SC + +  +
Sbjct: 2535 PHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQCVDE-NECALSPPTCGSASCRNTLGGF 2591

Query: 1145 LCSCPPG-----TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY 1197
             C CP G      LG   E++E     GP       C ++  C +  GGF C CP GY
Sbjct: 2592 RCVCPSGFDFDQALGGCQEVDECAGRRGP-------CSYS--CANTPGGFLCGCPQGY 2640



 Score =  404 bits (1038), Expect = e-112
 Identities = 481/1744 (27%), Positives = 647/1744 (37%), Gaps = 379/1744 (21%)

Query: 43   CLDGSPCANGGRCTQ----LPSREAACLCPPGWVG----------ERCQLEDPCHSGPCA 88
            C+D + CA    C            +CLC PG++           + CQ    C +G C 
Sbjct: 529  CVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCT 588

Query: 89   G-----RGVCQSSVVAGT---------ARFSC-------RCPRGFRGPD------CSLPD 121
                  R  C   +  GT          R +C        C R F G        C+ PD
Sbjct: 589  NTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPD 648

Query: 122  PCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSF 181
                 PC     C       F   C  G    +   D++EC +       G C N  GS+
Sbjct: 649  HGFGEPCQ---LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSY 705

Query: 182  RCQCPAGY----TGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE-GQNCEV- 235
            RC C  GY    +G  C +       S   + G C+ S   +Y C+C PGF   Q+ E+ 
Sbjct: 706  RCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPG-SYSCSCPPGFHFWQDTEIC 764

Query: 236  -NVDDCPGHRCLNGGTCVDGVNTYNCQCPP----EWTGQFCTEDV----------DECQL 280
             +VD+C    C++G  C +   +Y C+C P    + +G FC +              C++
Sbjct: 765  KDVDECLSSPCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEV 823

Query: 281  QPNACHNGGTCFNTLG---GHSC-------VCVNGW---TGESCSQNIDDCAT--AVCFH 325
                      C  TLG   G  C        C  G+   TG +C  ++++C +   VC +
Sbjct: 824  NLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPN 882

Query: 326  GATCHDRVASFYCACPMGKTGLLCHLDDACVS---NPCH----EDAICDTNPVNGRA-IC 377
            G  C +   SF C CP G   +L      CV     PC     ED    T P   R  +C
Sbjct: 883  GR-CVNTAGSFRCECPEGL--MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVC 939

Query: 378  TCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY------TGPRCETD 431
             C  G   G       EC    +P        + + + LC  G G+      +G     D
Sbjct: 940  CCSIGAVWGV------ECEACPDP-------ESLEFASLCPRGLGFASRDFLSGRPFYKD 986

Query: 432  VNEC--LSGPCRNQATCLDRIGQFTCICMAGFTGTYCE---VDIDECQSSPCVNG-GVCK 485
            VNEC    G C +  TC + +G F C C  GF     E    DIDEC+ SP + G G C 
Sbjct: 987  VNECKVFPGLCTH-GTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCV 1045

Query: 486  DRVNGFSCTC----PSGFSGSTCQLDVDECASTP--CRNGAKCVDQPDGYECRCAEGFE- 538
            +    F C C     SGF      +DVDECA  P  CR G  C +    Y+C+C  G E 
Sbjct: 1046 NTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT-CTNTDGSYKCQCPPGHEL 1104

Query: 539  ---GTLCDRNVDDCSPDP--CHHGRCVDGIASFSCACAPGYTGTRCES---QVDECRSQP 590
               GT C+ ++D+CS     C HG+CV+ I +F C+C  G+  T        ++ECR Q 
Sbjct: 1105 TAKGTACE-DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQN 1163

Query: 591  CRHGGKCLDLVDKYLCRCPSGTT----GVNCEVNIDDCASNP--CTFGVCRDGINRYDCV 644
                  C++    Y C C  G +    G  C  ++D+C  NP  C  G C +    + C+
Sbjct: 1164 GGCDVHCINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCL 1222

Query: 645  CQPGFTGP----LCNVEINECASSP--CGEGGSCVDGENGFRCLCPPGSLPPL------- 691
            C  GF        C V+++EC  +P  C  G  C + +  F C C  G +          
Sbjct: 1223 CYDGFMATPDMRTC-VDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGATGCSD 1280

Query: 692  ---CLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGP--RCSQSLARDACESQP--CR 744
               C    H C     SH  C + PG F C C PGW G    C      D C SQ   C 
Sbjct: 1281 VDECEVGGHNCD----SHASCLNIPGSFSCRCLPGWVGDGFECHDL---DECVSQEHRCS 1333

Query: 745  AGGTCSSDGMGFHCTCPPGVQGRQ--CELLSPCTPNP--CEHGGRCESAPGQLPVCSCPQ 800
              G C +    + CTC  G  G    CE    C  N   C++G +C +APG    C C  
Sbjct: 1334 PRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNG-QCLNAPGGYR-CECEM 1391

Query: 801  GW---QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT----GPSCDQDIND- 852
            G+   +  R  QDVDECA    C   G C NL G F C C+GGY     G +C  DIN+ 
Sbjct: 1392 GFDPTEDHRACQDVDECAQGNLCA-FGSCENLPGMFRCICNGGYELDRGGGNCT-DINEC 1449

Query: 853  -----CDPNPCLN------------------GGSCQD----------------------- 866
                 C    C+N                  G  C D                       
Sbjct: 1450 ADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAE 1509

Query: 867  ---GVGSFSCSCLPGFA-GPRCA-----------------------------RDVDECLS 893
               GV   SC C  G A G  C                               D+DEC  
Sbjct: 1510 IGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQE 1569

Query: 894  NP--CGPGTCTDHVASFTCTCPPGYGGFH----CEQDLPDCSPSSCFNG-GTCVDGVNSF 946
             P  C  G C +   SF C CPPGY        CE D+ +CS  S   G GTC + + ++
Sbjct: 1570 LPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE-DIDECSTHSGICGPGTCYNTLGNY 1628

Query: 947  SCLCRPGYTGAHCQHEADPCLSRPCL--HGGVCS--AAHPGFRCTCLESFTGPQCQTLVD 1002
            +C+C   Y   +  +         C   + G C    A    R  C  S+   Q      
Sbjct: 1629 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQA----- 1683

Query: 1003 WCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRS---LPCREAAAQIGVRLEQLCQAGG 1059
            W   +PC+     +      LC     G L DI +   L   E        +  +C A G
Sbjct: 1684 W--NRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG-----EIPAIC-ANG 1735

Query: 1060 QCVDEDSSHYCVCPEGRTGSH----CEQEVDPCLAQ--PCQHGGTCRGYMGGYMCECLPG 1113
             C+++  S  C CP G   +     CE +VD C ++  PCQ    C    G Y C+C  G
Sbjct: 1736 ICINQIGSFRCECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRG 1794

Query: 1114 YN---GDNCEDDVDECASQP--CQHGGSCIDLVARYLCSCPPGTLG----VLCEINEDDC 1164
            Y    G  C    +EC   P  C HG  C+D    Y+C C  G        LC ++ D+C
Sbjct: 1795 YKLSPGGACVGR-NECREIPNVCSHG-DCMDTEGSYMCLCHRGFQASADQTLC-MDIDEC 1851

Query: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR---CEADINECRSGACHAAHTRD 1221
               P          NGTC +++G + C C PG+       C  D +EC +          
Sbjct: 1852 DRQP--------CGNGTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFGH 1902

Query: 1222 CLQDPGGGFRCLCHAGFS----GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHC 1277
            CL +  G F CLC  GF     G  C    + C S      G C P        +F C C
Sbjct: 1903 CL-NTAGSFHCLCQDGFELTADGKNCVDT-NECLSL----AGTCLPGTCQNLEGSFRCIC 1956

Query: 1278 AQPFW--GPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPG--LSGPSCRSFPGSPPG 1333
               F      C  +     E    +   C  +P   +C CPPG  LS    R F      
Sbjct: 1957 PPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD----- 2011

Query: 1334 ASNASCAAAPCLHGGSCRPAPLA---PFFRCACA----QGWTGPRCEAPAAAPEVSEEPR 1386
               + C        G C   P A      RC C+    +GW  P CE        + +  
Sbjct: 2012 TRQSFCFTR--FEAGKCS-VPKAFNTTKTRCCCSKRPGEGWGDP-CELCPQEGSAAFQEL 2067

Query: 1387 CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSV---GDPWRQCEALQCWRL-FNNSRC 1442
            CP     A  G      + N   C  + G C+  V    D   +CE    + L F    C
Sbjct: 2068 CPFGH-GAVPGPDDSREDVNE--CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC 2124

Query: 1443 DPACSSPACLYDNFDCHAGGR--ERTCNPV---YEKYCADHFADGRCDQGCNTEECGWDG 1497
                       D  +C  G    + TC  V   +E  CAD F  G      + +EC  + 
Sbjct: 2125 ----------VDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNP 2174

Query: 1498 LDCA 1501
            L CA
Sbjct: 2175 LLCA 2178



 Score =  375 bits (963), Expect = e-103
 Identities = 419/1520 (27%), Positives = 595/1520 (39%), Gaps = 330/1520 (21%)

Query: 104  FSCRCPRGF----RGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS-- 157
            + C C  G+    RG +C   D C SSPC HG   ++   G + C C PG+Q    R   
Sbjct: 431  YRCECNVGYTQDVRG-ECIDVDECTSSPCHHGDCVNI--PGTYHCRCYPGFQATPTRQAC 487

Query: 158  -DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY----TGPLCENPAVPCAPSPCRNGGTC 212
             DVDEC V     H G C+NT GSF+C C AG+     G  C +       + C NG   
Sbjct: 488  VDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCL 547

Query: 213  RQSGDLTYDCACLPGF---EGQNCEVNVDDC--PGHRCLNGGTCVDGVNTYNCQC----P 263
             + G  ++ C C PGF    G +  +++D+C  PG  C+N G C +   ++ CQC     
Sbjct: 548  NEDG--SFSCLCKPGFLLAPGGHYCMDIDECQTPG-ICVN-GHCTNTEGSFRCQCLGGLA 603

Query: 264  PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWT---GESCSQNIDDCAT 320
                G+ C +            H   TC+  +   SC      T    E C  N D    
Sbjct: 604  VGTDGRVCVD-----------THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFG 652

Query: 321  AVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCP 380
              C              C+  +G T     +++  +      + +C+   + G   C C 
Sbjct: 653  EPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCEN--LRGSYRCVCN 710

Query: 381  PGFTGGACDQ---DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY---TGPRCETDVNE 434
             G+  GA  +   DVDEC++ +  C++ G C N+ GS+ C C  G+          DV+E
Sbjct: 711  LGYEAGASGKDCTDVDECALNSLLCDN-GWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769

Query: 435  CLSGPCRNQATCLDRIGQFTCICMAGF----TGTY-----------------CEVDI--- 470
            CLS PC +   C +  G +TC C  G     +GT+                 CEV++   
Sbjct: 770  CLSSPCVS-GVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828

Query: 471  ---DECQSSPCVNGGVCKDRVNGFSCTCPSGF---SGSTCQLDVDECASTP--CRNGAKC 522
                EC ++     G   +R       C  GF   +G TC  DV+EC S P  C NG +C
Sbjct: 829  SLRSECCATLGAAWGSPCERCE-IDPACARGFARMTGVTCD-DVNECESFPGVCPNG-RC 885

Query: 523  VDQPDGYECRCAEGF----EGTLC-DRNVDDC----SPDPCHHGRCVDGIASFS-CACAP 572
            V+    + C C EG      G LC D  ++ C      D C  G  + G      C C+ 
Sbjct: 886  VNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC--GVTLPGKYRMDVCCCSI 943

Query: 573  GYT-GTRCES--------------------------------QVDECRSQP--CRHGGKC 597
            G   G  CE+                                 V+EC+  P  C H G C
Sbjct: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH-GTC 1002

Query: 598  LDLVDKYLCRCPSG----TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFTG 651
             + V  + C C  G        NC  +ID+C  +P  C  G C +    ++C C PG+  
Sbjct: 1003 RNTVGSFHCACAGGFALDAQERNC-TDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061

Query: 652  PLC----NVEINECASSP-CGEGGSCVDGENGFRCLCPPG---SLPPLCLPPSHPCAHEP 703
                    ++++ECA  P    GG+C + +  ++C CPPG   +           C+   
Sbjct: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSD 1121

Query: 704  --CSHGICYDAPGGFRCVCEPGW-SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC 760
              C HG C +  G F+C C  G+ S P     +  + C  Q       C +    + C+C
Sbjct: 1122 GLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSC 1181

Query: 761  PPGV----QGRQCELLSPCTPNP--CEHGGRCESAPGQLPVCSCPQGWQGP---RCQQDV 811
              G      GR C  +  C  NP  C+  G C + PG    C C  G+      R   DV
Sbjct: 1182 GQGYSLMPDGRACADVDECEENPRVCDQ-GHCTNMPGG-HRCLCYDGFMATPDMRTCVDV 1239

Query: 812  DEC-AGPAPCGPHGICTNLAGSFSCTCHGGY---TGPSCDQDINDCD--PNPCLNGGSCQ 865
            DEC   P  C  HG C N  GSF C C  GY    G +   D+++C+   + C +  SC 
Sbjct: 1240 DECDLNPHIC-LHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCL 1298

Query: 866  DGVGSFSCSCLPGFAGPRC-ARDVDECLS--NPCGP-GTCTDHVASFTCTCPPGYG--GF 919
            +  GSFSC CLPG+ G      D+DEC+S  + C P G C +   S+ CTC  G+   GF
Sbjct: 1299 NIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF 1358

Query: 920  HCEQDLPDCSPS-SCFNGGTCVDGVNSFSCLCRPGY--TGAH--CQHEADPCLSRPCLHG 974
             CE D  +C+ +    + G C++    + C C  G+  T  H  CQ + D C        
Sbjct: 1359 FCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ-DVDECAQGNLCAF 1416

Query: 975  GVCSAAHPGFRCTCLESFT----GPQCQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGW 1028
            G C      FRC C   +     G  C  + +      C N G C+ T G+Y C CP  +
Sbjct: 1417 GSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCIN-GVCINTPGSYLCSCPQDF 1475

Query: 1029 ----SGRLC-DIRSLPC-----------REAAAQIGV---RLEQLCQAGGQ-------CV 1062
                SG  C D R+  C              +A+IGV   R    C  G         C 
Sbjct: 1476 ELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCP 1535

Query: 1063 DEDSSHY-CVCPEGRTGSHCE-----QEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY 1114
              +++ Y  +CP G            +++D C   P  CQ GG C    G + CEC PGY
Sbjct: 1536 MANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGY 1594

Query: 1115 NGDN----CEDDVDECASQPCQHG-GSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPP 1169
            +       CE D+DEC++     G G+C + +  Y C CP   L V              
Sbjct: 1595 HLSEHTRICE-DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQV-------------- 1639

Query: 1170 LDSGPRCL----------HNGTCVDLVGGFRCT--------------------CP----- 1194
             + G  C+          +NGTC + +  F  T                    CP     
Sbjct: 1640 -NGGNNCMDMRKSVCFRHYNGTCQNEL-AFNVTRKMCCCSYNIGQAWNRPCEACPTPISP 1697

Query: 1195 ----------PGY-----TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS 1239
                      PG+     TG     DI+EC  G   A        +  G FRC C AGF+
Sbjct: 1698 DYQILCGNQAPGFLTDIHTGK--PLDIDEC--GEIPAICANGICINQIGSFRCECPAGFN 1753

Query: 1240 GPRCQTVLSPCE--------SQPCQHGGQCRPSPGPGGGLTFTCHCAQPF-WGPRCERVA 1290
                 ++L  CE          PCQ    C   PG     ++ C C + +   P    V 
Sbjct: 1754 ---YNSILLACEDVDECGSRESPCQQNADCINIPG-----SYRCKCTRGYKLSPGGACVG 1805

Query: 1291 RS-CRELQ--CPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHG 1347
            R+ CRE+   C  G  C  T     C C  G    + ++            C   PC   
Sbjct: 1806 RNECREIPNVCSHG-DCMDTEGSYMCLCHRGFQASADQTL-----CMDIDECDRQPC-GN 1858

Query: 1348 GSCRPAPLAPFFRCACAQGW 1367
            G+C+   +   + C C  G+
Sbjct: 1859 GTCK--NIIGSYNCLCFPGF 1876



 Score =  366 bits (940), Expect = e-100
 Identities = 423/1469 (28%), Positives = 551/1469 (37%), Gaps = 318/1469 (21%)

Query: 185  CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHR 244
            CP   T P      VP     C  G  C Q       C C  G    +C V+        
Sbjct: 69   CPGWRTFPGRSQCVVPICRRACGEG-FCSQPNL----CTCADGTLAPSCGVSRGSGCSVS 123

Query: 245  CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVN 304
            C+NGGTC       +C C   +TG  C + + +       CHNGG C   +G + C CV 
Sbjct: 124  CMNGGTCRGA----SCLCQKGYTGTVCGQPICD-----RGCHNGGRC---IGPNRCACVY 171

Query: 305  GWTGESCSQNIDDCATAVCFHGAT---CHDRVASFYCA-----CPMGKT-GLLCHLDDAC 355
            G+ G  C +   D  T  CF       C  ++    C        +G+  GL C L  A 
Sbjct: 172  GFMGPQCER---DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPA- 227

Query: 356  VSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSF 415
              +PC    I               P    GAC QDVDEC      C+  G CVN  GSF
Sbjct: 228  QPHPCRRGFI---------------PNIHTGAC-QDVDECQAVPGLCQG-GSCVNMVGSF 270

Query: 416  LCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTY----CEVDID 471
             C+C  G+          +  +G C +          F   C     G Y    C  D  
Sbjct: 271  HCRCPVGHRLSDSSAACEDYRAGACFSVL--------FGGRCAGDLAGHYTRRQCCCDRG 322

Query: 472  ECQSSPCVNGGVCKDR-VNGFSCTC----------PSGFSGSTCQLDVDECASTPCRNGA 520
             C ++  V   +C  R  N F   C          P  F G    L        P    A
Sbjct: 323  RCWAAGPVPE-LCPPRGSNEFQQLCAQRLPLLPGHPGLFPGL---LGFGSNGMGPPLGPA 378

Query: 521  KCVDQPDGYECRCAEGFE------GTLC-DRNVDDCS--PDPCHHGRCVDGIASFSCACA 571
            +    P G + R            GT   ++ +D C    + C +GRC+   +S+ C C 
Sbjct: 379  RL--NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECN 436

Query: 572  PGYT-GTRCES-QVDECRSQPCRHGGKCLDLVDKYLCRCPSG---TTGVNCEVNIDDC-- 624
             GYT   R E   VDEC S PC HG  C+++   Y CRC  G   T      V++D+C  
Sbjct: 437  VGYTQDVRGECIDVDECTSSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIV 495

Query: 625  ASNPCTFGVCRDGINRYDCVCQPGFT----GPLCNVEINECASSPCGEGGSCVDGENGFR 680
            +   C  G C +    + CVC  GF     G  C V+ NECA+S     G C++ +  F 
Sbjct: 496  SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGVCLNEDGSFS 554

Query: 681  CLCPPGSLPPLCLPPSHPC-----AHEP--CSHGICYDAPGGFRCVC----EPGWSGPRC 729
            CLC PG L     P  H C        P  C +G C +  G FRC C      G  G  C
Sbjct: 555  CLCKPGFL---LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611

Query: 730  SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG--GRCE 787
              +  R  C     +  G+C+          P  V   +C     C  NP +HG    C+
Sbjct: 612  VDTHVRSTCYGAIEK--GSCARP-------FPGTVTKSEC-----CCANP-DHGFGEPCQ 656

Query: 788  SAPGQLPV---CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY--- 841
              P +        C  G       +D++ECA       +G+C NL GS+ C C+ GY   
Sbjct: 657  LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAG 716

Query: 842  -TGPSCDQDINDCDPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECLSNPC 896
             +G  C  D+++C  N  L + G CQ+  GS+SCSC PGF         +DVDECLS+PC
Sbjct: 717  ASGKDCT-DVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPC 775

Query: 897  GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNG--GTCVDGVNSFSCLCRPGY 954
              G C +   S+TC C PG           D S + C +   GTC   +      C    
Sbjct: 776  VSGVCRNLAGSYTCKCGPG--------SRLDPSGTFCLDSTKGTC--WLKIQESRCEVNL 825

Query: 955  TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCT-CLESFTGPQCQTLVDWCSRQP--CQN 1011
             GA  + E   C +     G  C        C       TG  C   V+ C   P  C N
Sbjct: 826  QGASLRSEC--CATLGAAWGSPCERCEIDPACARGFARMTGVTCDD-VNECESFPGVCPN 882

Query: 1012 GGRCVQT-GAY-CLCPPGW----SGRLC-DIRSLPC--REAAAQIGV------RLEQLCQ 1056
             GRCV T G++ C CP G     SGRLC D+R  PC  R    + GV      R++  C 
Sbjct: 883  -GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCC 941

Query: 1057 AGG--------QCVDEDSSHYC-VCPEG--------RTGSHCEQEVDPCLAQP--CQHG- 1096
            + G         C D +S  +  +CP G         +G    ++V+ C   P  C HG 
Sbjct: 942  SIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT 1001

Query: 1097 ----------------------------------------GTCRGYMGGYMCECLPGYNG 1116
                                                    GTC    G + CEC PGY  
Sbjct: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061

Query: 1117 -----DNCEDDVDECASQPCQ-HGGSCIDLVARYLCSCPPG----TLGVLCEINEDDCGP 1166
                  NC  DVDECA  P    GG+C +    Y C CPPG      G  CE + D+C  
Sbjct: 1062 GFMLMKNCM-DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSL 1119

Query: 1167 GPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE---ADINECR--SGAC--HAAHT 1219
               L     C H G CV+++G F+C+C  G+          DINECR  +G C  H  +T
Sbjct: 1120 SDGL-----CPH-GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINT 1173

Query: 1220 RDCLQDPGGGFRCLCHAGFS----GPRCQTVLSPCESQP--CQHGGQCRPSPGPGGGLTF 1273
                    G +RC C  G+S    G  C  V   CE  P  C   G C   PG    L +
Sbjct: 1174 E-------GSYRCSCGQGYSLMPDGRACADV-DECEENPRVCDQ-GHCTNMPGGHRCLCY 1224

Query: 1274 TCHCAQPFWGPRCERVARSCREL-QCPVGV------PCQQTPRGPRCACPPGL----SGP 1322
                A P          R+C ++ +C +         C+ T     C C  G        
Sbjct: 1225 DGFMATP--------DMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGAT 1276

Query: 1323 SCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVS 1382
             C        G  N       C    SC   P +  F C C  GW G   E       VS
Sbjct: 1277 GCSDVDECEVGGHN-------CDSHASCLNIPGS--FSCRCLPGWVGDGFECHDLDECVS 1327

Query: 1383 EEPRC-PRAACQAKRGDQRCDRECNSPGCGW---DGGDCSLSVGDPWRQCEALQCWRLFN 1438
            +E RC PR  C    G  RC       G G+   D  +C+ +V      C+  QC     
Sbjct: 1328 QEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD----LCDNGQCLNAPG 1383

Query: 1439 NSRC------DPACSSPACLYDNFDCHAG 1461
              RC      DP     AC  D  +C  G
Sbjct: 1384 GYRCECEMGFDPTEDHRAC-QDVDECAQG 1411



 Score =  351 bits (900), Expect = 5e-96
 Identities = 295/969 (30%), Positives = 402/969 (41%), Gaps = 173/969 (17%)

Query: 121  DPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGRSCR---SDVDECRVGE-PCRHGGTC 174
            D C   P  CA+G    +   G F C CP G+   S      DVDEC   E PC+    C
Sbjct: 1723 DECGEIPAICANGI--CINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADC 1780

Query: 175  LNTPGSFRCQCPAGYTGPLCENPAVPCA--------PSPCRNGGTCRQSGDLTYDCACLP 226
            +N PGS+RC+C  GY      +P   C         P+ C +G      G  +Y C C  
Sbjct: 1781 INIPGSYRCKCTRGYK----LSPGGACVGRNECREIPNVCSHGDCMDTEG--SYMCLCHR 1834

Query: 227  GFEG---QNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEW--TGQFCTEDVDECQLQ 281
            GF+    Q   +++D+C    C NG TC + + +YNC C P +  T      D DEC   
Sbjct: 1835 GFQASADQTLCMDIDECDRQPCGNG-TCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTL 1893

Query: 282  PNACHNGGTCFNTLGGHSCVCVNGWT----GESCSQNIDDCATAVCFHGATCHDRVASFY 337
                   G C NT G   C+C +G+     G++C    +  + A      TC +   SF 
Sbjct: 1894 VGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953

Query: 338  CACPMGKTGLLCHLDDACVSNPCHED------AICDTNPVNGRAICTCPPGFT----GGA 387
            C CP G      H  D    + C E+        C  +P  G   C CPPGF     G  
Sbjct: 1954 CICPPGFQVQSDHCIDI---DECSEEPNLCLFGTCTNSP--GSFQCLCPPGFVLSDNGHR 2008

Query: 388  CDQ----------DVDECSIG--------------------ANPCEHLGRCVNTQGSFLC 417
            C            +  +CS+                      +PCE   +  +     LC
Sbjct: 2009 CFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELC 2068

Query: 418  QCGRGYT-GPR-CETDVNECLSGP--CRNQATCLDRIGQFTCICMAG----FTGTYCEVD 469
              G G   GP     DVNEC   P  C N   C++  G F C C  G    FTG  C VD
Sbjct: 2069 PFGHGAVPGPDDSREDVNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTGINC-VD 2126

Query: 470  IDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGS---TCQLDVDECASTPCRNGAKCVDQP 526
             DEC        G C + + GF C C  GF      TC+ D+DEC+  P     +C +  
Sbjct: 2127 TDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTE 2185

Query: 527  DGYECRCAEGF----EGTLCDRNVDDCSP--DPCHHG--RCVDGIASFSCACAPGY---- 574
              Y C C  G+    +G +C R+VD+C+     CH     C + I +F+C C PG     
Sbjct: 2186 GSYLCTCPAGYTLREDGAMC-RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLP 2244

Query: 575  -TGTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF 631
             +G  C    +EC +QP  C +G +C++    + C C  G           D    PC  
Sbjct: 2245 GSGEGCTDD-NECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFA 2302

Query: 632  GV----CR------DGINRYDCVCQPGFT-GPLCNVEINECASSPCGEGGSCVDGENGFR 680
             V    CR      + + R +C C  G   GP C +    C           + G + +R
Sbjct: 2303 EVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL----CP----------LPGTSAYR 2348

Query: 681  CLCPPGS---LPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS-LARD 736
             LCP GS        +      AH  C+HG C ++ G FRC C+ G++    + + L  D
Sbjct: 2349 KLCPHGSGYTAEGRDVDECRMLAHL-CAHGECINSLGSFRCHCQAGYTPDATATTCLDMD 2407

Query: 737  ACESQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPCTPNPCEHGGRCESAPGQ 792
             C   P      C +    F C+CP G      GR C+ L  CT         C +  G 
Sbjct: 2408 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA 2467

Query: 793  LPVCSCPQGW-QGPRCQQDVDEC-AGPAPCGPHGICTNLAGSFSCTCHGGYT----GPSC 846
               C CP G+ Q  +   D DEC A P PCG HG C N  GSF C CH G+T    G  C
Sbjct: 2468 F-TCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC 2526

Query: 847  DQDINDCD-PNPCLNGGSCQDGVGSFSCSCLPGFA----GPRCARDVDECLSNP--CGPG 899
             +D+N+CD P+ C +G  CQ+ +G + CSC  GF       +C  D +EC  +P  CG  
Sbjct: 2527 -EDVNECDGPHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQCV-DENECALSPPTCGSA 2582

Query: 900  TCTDHVASFTCTCPPGY------GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPG 953
            +C + +  F C CP G+      GG    Q++ +C+        +C +    F C C  G
Sbjct: 2583 SCRNTLGGFRCVCPSGFDFDQALGGC---QEVDECAGRRGPCSYSCANTPGGFLCGCPQG 2639

Query: 954  YTGA---HC 959
            Y  A   HC
Sbjct: 2640 YFRAGQGHC 2648



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 149/601 (24%), Positives = 190/601 (31%), Gaps = 133/601 (22%)

Query: 946  FSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCS 1005
            F   C PG+     + +    + R     G CS  +    CTC +    P C        
Sbjct: 64   FHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPN---LCTCADGTLAPSCGVSRGSGC 120

Query: 1006 RQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDED 1065
               C NGG C   GA CLC  G++G +       C +     G      C  GG+C+  +
Sbjct: 121  SVSCMNGGTC--RGASCLCQKGYTGTV-------CGQPICDRG------CHNGGRCIGPN 165

Query: 1066 SSHYCVCPEGRTGSHCEQE--VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV 1123
                C C  G  G  CE++    PC  Q    G  C+  + G +C          C   V
Sbjct: 166  R---CACVYGFMGPQCERDYRTGPCFGQVGPEG--CQHQLTGLVC------TKALCCATV 214

Query: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTL--GVLCEINEDDCGPGPPLDSGPRCLHNGT 1181
                  PC+            LC   P     G +  I+   C       + P     G+
Sbjct: 215  GRAWGLPCE------------LCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS 262

Query: 1182 CVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAA-HTRDCLQDPGGGF---RCLCHAG 1237
            CV++VG F C CP G+      A   + R+GAC +      C  D  G +   +C C  G
Sbjct: 263  CVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322

Query: 1238 FSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQ 1297
                RC       E  P            P G   F   CAQ    P           L 
Sbjct: 323  ----RCWAAGPVPELCP------------PRGSNEFQQLCAQRL--PLLPGHPGLFPGL- 363

Query: 1298 CPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP-----CLH------ 1346
               G      P GP    P    G   R  P   PG SN   A        C H      
Sbjct: 364  LGFGSNGMGPPLGPARLNP---HGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 420

Query: 1347 GGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECN 1406
             G C P P +  +RC C  G+T                        Q  RG+     EC 
Sbjct: 421  NGRCLPTPSS--YRCECNVGYT------------------------QDVRGECIDVDECT 454

Query: 1407 SPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPAC-SSPACLYDNFDCHAGGRER 1465
            S  C    GDC    G     C   +C+  F  +    AC     C+     CH G    
Sbjct: 455  SSPC--HHGDCVNIPGT--YHC---RCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVN 507

Query: 1466 T-------CNPVYE-----KYCADH---FADGRCDQGCNTEECGWDGLDCASEVPALLAR 1510
            T       CN  +E     K C DH        C  G    E G     C  +   LLA 
Sbjct: 508  TEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDG--SFSCLCKPGFLLAP 565

Query: 1511 G 1511
            G
Sbjct: 566  G 566



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 44/163 (26%), Positives = 55/163 (33%), Gaps = 47/163 (28%)

Query: 1270 GLTFTCHCAQPFWGP---RCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326
            G  F  +C  P W     R + V   CR   C  G   Q       C C  G   PSC  
Sbjct: 61   GSRFHAYCC-PGWRTFPGRSQCVVPICRRA-CGEGFCSQPN----LCTCADGTLAPSC-- 112

Query: 1327 FPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPR 1386
                  G S  S  +  C++GG+CR A       C C +G+TG  C  P           
Sbjct: 113  ------GVSRGSGCSVSCMNGGTCRGAS------CLCQKGYTGTVCGQPI---------- 150

Query: 1387 CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCE 1429
                          CDR C++ G       C+   G    QCE
Sbjct: 151  --------------CDRGCHNGGRCIGPNRCACVYGFMGPQCE 179


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  446 bits (1147), Expect = e-124
 Identities = 443/1524 (29%), Positives = 603/1524 (39%), Gaps = 286/1524 (18%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVGER----CQLEDPCHSGPCAGRGVCQSSVV 98
            C D     +GG+CT +P  E  CLC  G++       C   + C   P     +C S   
Sbjct: 1242 CEDNPNICDGGQCTNIPG-EYRCLCYDGFMASEDMKTCVDVNECDLNP----NICLSGTC 1296

Query: 99   AGT-ARFSCRCPRGFRGPD----CSLPDPCL--SSPCAHGARCSVGPDGRFLCSCPPGYQ 151
              T   F C C  G+ G      C+  + C   +  C   A C+    G F CSC PG+ 
Sbjct: 1297 ENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCT-NTAGSFKCSCSPGWI 1355

Query: 152  GRSCR-SDVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGP--LCENPAVPCAPSP-- 205
            G   + +D+DEC  G   C     C NT GS+RC C  GYTG    C +    C+ +   
Sbjct: 1356 GDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTD-LDECSENLNL 1414

Query: 206  CRNGGTCRQSGDLTYDCACLPGF----EGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQ 261
            C NG      G   Y C C  GF    +G+ CE ++D+C        GTC +    + C+
Sbjct: 1415 CGNGQCLNAPGG--YRCECDMGFVPSADGKACE-DIDECSLPNICVFGTCHNLPGLFRCE 1471

Query: 262  CPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDD 317
            C   +    +G  CT DV+EC L P  C +G  C NT G + C C   +          D
Sbjct: 1472 CEIGYELDRSGGNCT-DVNEC-LDPTTCISGN-CVNTPGSYICDCPPDFELNPTRVGCVD 1528

Query: 318  CATAVCF--------HGAT-CHDR----VASFYCACPMGKTG----------------LL 348
              +  C+        +G T C +     V+   C C +GK                  +L
Sbjct: 1529 TRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKIL 1588

Query: 349  CHLDDACVSNP----------CHE-DAICDTNP-VN--GRAICTCPPGF----TGGACDQ 390
            C   +    NP          C E   +C     +N  G   C CP G+        CD 
Sbjct: 1589 CPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCD- 1647

Query: 391  DVDECSIGA--NPCEHLGRCVNTQGSFLCQCGRGYT----GPRC---------------- 428
            DV+EC       P    G C NT G++ C C   Y     G  C                
Sbjct: 1648 DVNECETPGICGP----GTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADN 1703

Query: 429  ETDVNECLSGPCRNQATCLDRIG----------------QFTCICMAGFTG------TYC 466
            +T   E L    +    C   IG                +F  +C +   G      T  
Sbjct: 1704 QTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGL 1763

Query: 467  EVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFSGSTCQL---DVDECASTP-CRNGAK 521
             VDIDEC+  P V   GVC + V  F C CP GF  +   L   D+DEC + P C+  A+
Sbjct: 1764 PVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE 1823

Query: 522  CVDQPDGYECRCAEGFE----GTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGT 577
            C++    Y C C  G+     G   DRN     P+ C HG+C+D + SF C C  G+   
Sbjct: 1824 CINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTN 1883

Query: 578  RCESQ---VDECRSQPCRHGGKCLDLVDKYLCRCPSG--TTGVNCEVNIDDCAS---NPC 629
              ++    ++EC    C +G  C + +  + CRC  G   +  N  +++D+CAS   N C
Sbjct: 1884 DDQTMCLDINECERDACGNG-TCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLC 1942

Query: 630  TFGVCRDGINRYDCVCQPGFT----GPLCNVEINECASSP--CGEGGSCVDGENGFRCLC 683
              G C + +  + C C  G+     G  C V+INEC   P  C  G +C + +  +RC+C
Sbjct: 1943 RNGQCINTVGSFQCQCNEGYEVAPDGRTC-VDINECLLEPRKCAPG-TCQNLDGSYRCIC 2000

Query: 684  PPG-SLPPLCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGWS----GPRCSQSLARD 736
            PPG SL          C  EP  C+ G C +  G F+C+C  G+S    G RC Q L   
Sbjct: 2001 PPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRC-QDLRMS 2059

Query: 737  ACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVC 796
             C ++    GG CSS     H       Q   C L      +PCE    C + P +    
Sbjct: 2060 YCYAK--FEGGKCSSPKSRNHSK-----QECCCALKGEGWGDPCE---LCPTEPDEAFRQ 2109

Query: 797  SCPQGWQ---GPRCQQ-DVDECAGPAPCGPHGICTNLAGSFSCTCHGGY--TGPSCDQDI 850
             CP G     GP     D+DEC  P  C  HG C N  GS+ C C  GY   G  C  D 
Sbjct: 2110 ICPYGSGIIVGPDDSAVDMDECKEPDVC-KHGQCINTDGSYRCECPFGYILAGNEC-VDT 2167

Query: 851  NDCDP-NPCLNGGSCQDGVGSFSCSCLPGFA-GPRCA-RDVDECLSNP--CGPGTCTDHV 905
            ++C   NPC NG +C++ +G F C+C  GF  GP     D++EC  NP  C    C +  
Sbjct: 2168 DECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA-FRCVNTY 2225

Query: 906  ASFTCTCPPGY----------GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYT 955
             S+ C CP GY              CE+   DC+         C + + ++ C+C PGY 
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQM----ECKNLIGTYMCICGPGYQ 2281

Query: 956  ----GAHCQHEADPCLSRPCL-HGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQ 1010
                G  C  E + C ++P +   G C      + C C + FT    Q   D C      
Sbjct: 2282 RRPDGEGCVDENE-CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQ---DECLDN--- 2334

Query: 1011 NGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC 1070
              G C       +C  G S R    +S  C +     G   E +C   G    +      
Sbjct: 2335 REGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCE-ICPFQGTVAFKK----- 2388

Query: 1071 VCPEGRTGSHCEQEVDPC--LAQPCQHGGTCRGYMGGYMCECLPGYN----GDNCEDDVD 1124
            +CP GR       ++D C  +   C++G  C    G Y C C  GY     G +C D ++
Sbjct: 2389 LCPHGRGFMTNGADIDECKVIHDVCRNG-ECVNDRGSYHCICKTGYTPDITGTSCVD-LN 2446

Query: 1125 ECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGT--C 1182
            EC   P      C +    Y CSCP G       I ++D      LD      HN    C
Sbjct: 2447 ECNQAPKPCNFICKNTEGSYQCSCPKGY------ILQEDGRSCKDLDECATKQHNCQFLC 2500

Query: 1183 VDLVGGFRCTCPPGYT--------GLRCEADINECRS-GACHAAHTRDCLQDPGGGFRCL 1233
            V+ +GGF C CPPG+T           C +DIN C S G C         Q+  G F C 
Sbjct: 2501 VNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGIC---------QNTPGSFTCE 2551

Query: 1234 CHAGFS----GPRCQTVLSPCE-SQPCQHGGQCRPSPGPGGGLTFTCHCAQPF-----WG 1283
            C  GFS    G  C+ V   CE +  CQHG  C+   G      + C C Q +     W 
Sbjct: 2552 CQRGFSLDQTGSSCEDV-DECEGNHRCQHG--CQNIIG-----GYRCSCPQGYLQHYQWN 2603

Query: 1284 PRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP 1343
               +     C       G  C  T    +C CP G        F G     +    A AP
Sbjct: 2604 QCVDE--NECLSAHICGGASCHNTLGSYKCMCPAGF---QYEQFSGGCQDINECGSAQAP 2658

Query: 1344 CLHGGSCRPAPLAPFFRCACAQGW 1367
            C +G S         + C C  G+
Sbjct: 2659 CSYGCSNTEGG----YLCGCPPGY 2678



 Score =  413 bits (1061), Expect = e-114
 Identities = 433/1671 (25%), Positives = 626/1671 (37%), Gaps = 381/1671 (22%)

Query: 49   CANGGRCTQLPSREAACLCPPGWV----GERC---QLEDPCHSGPCAGRGVCQSSVVAGT 101
            C NG RC         C C PG      G  C    +   C+ G    RG C   +    
Sbjct: 623  CMNG-RCVNTDG-SYRCECFPGLAVGLDGRVCVDTHMRSTCYGG--YKRGQCIKPLFGAV 678

Query: 102  ARFSCRCPRGFRGPDCSLPDPCLSSPCAHGAR--------------------CSVGPD-- 139
             +  C C       + +  +PC   P  + A                     C++ PD  
Sbjct: 679  TKSECCCA----STEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDIC 734

Query: 140  ---------GRFLCSCPPGYQ----GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCP 186
                     G + C C  GY+    G++C  D++EC +       G C NTPGSF C CP
Sbjct: 735  PNGICENLRGTYKCICNSGYEVDSTGKNC-VDINECVLNSLLCDNGQCRNTPGSFVCTCP 793

Query: 187  AGYTG----PLCENPAVPCAPSPCRNGGTCRQSGDLTYDCA-----------CLPGFEGQ 231
             G+        CE+    C  SPC NG      G    +C+           C+   +G 
Sbjct: 794  KGFIYKPDLKTCED-IDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGT 852

Query: 232  --------NCEVNVDDCP-GHRCLNGGTCVDGVNTYNCQCPP-------EWTGQFCTEDV 275
                     CE+N++      +C +      G     CQ  P          G  C ED+
Sbjct: 853  CWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQC-EDI 911

Query: 276  DECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVAS 335
            DEC++ P  C N G C NT G   C C +G T ++  +   D     CF      D   +
Sbjct: 912  DECEVFPGVCKN-GLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCF--LRYEDEECT 968

Query: 336  FYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF------TGGACD 389
               A         C +  A  +  C E  +   N      +C   PGF       G    
Sbjct: 969  LPIAGRHRMDACCCSVGAAWGTEECEECPM--RNTPEYEELCPRGPGFATKEITNGKPFF 1026

Query: 390  QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY---TGPRCETDVNEC-LSGPCRNQAT 445
            +D++EC +  + C H G+C NT GSF C+C  G+   +  R  TD++EC +S     +  
Sbjct: 1027 KDINECKMIPSLCTH-GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ 1085

Query: 446  CLDRIGQFTCICMAGFTGTYCE----VDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFS 500
            C++  G F C C  G+   +      +DIDECQ  P +  GGVC +    + C CP G  
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQ 1145

Query: 501  GS---TCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFEGT---LCDRNVDDCS-P 551
             S   +  +D++EC  ++  C NG +CV+    Y+C C  G+  T   L   ++D+CS  
Sbjct: 1146 LSPNISACIDINECELSAHLCPNG-RCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIM 1204

Query: 552  DPCHHGRCVDGIASFSCACAPGYT---GTRCESQVDECRSQP-CRHGGKCLDLVDKYLCR 607
            +      C +   S+ C+C PG+      R  + +DEC   P    GG+C ++  +Y C 
Sbjct: 1205 NGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCL 1264

Query: 608  CPSG---TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFTGPLCN---VEIN 659
            C  G   +  +   V++++C  NP  C  G C +    + C C  G++G        +IN
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDIN 1324

Query: 660  EC--ASSPCGEGGSCVDGENGFRCLCPPGSLP--------PLCLPPSHPCAHEPCSHGIC 709
            EC   +  CG+   C +    F+C C PG +           C   +H C+     H  C
Sbjct: 1325 ECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCS----QHADC 1380

Query: 710  YDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCP----PGVQ 765
             +  G +RC+C+ G++G   + +   +  E+      G C +   G+ C C     P   
Sbjct: 1381 KNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSAD 1440

Query: 766  GRQCELLSPCT-PNPCEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECAGPAPC 820
            G+ CE +  C+ PN C   G C + PG L  C C  G++    G  C  DV+EC  P  C
Sbjct: 1441 GKACEDIDECSLPNICVF-GTCHNLPG-LFRCECEIGYELDRSGGNC-TDVNECLDPTTC 1497

Query: 821  GPHGICTNLAGSFSCTCHGGY----TGPSC-DQDINDC--DPNPCLNGG--SCQD----G 867
               G C N  GS+ C C   +    T   C D    +C  D  P  + G  +C +    G
Sbjct: 1498 -ISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVG 1556

Query: 868  VGSFSCSC------------------------LPGFAGPR------CARDVDECLSNP-- 895
            V   SC C                         PG  G R         D+DEC   P  
Sbjct: 1557 VSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGL 1616

Query: 896  CGPGTCTDHVASFTCTCPPGY---GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRP 952
            C  G C +   SF C CP GY          D+ +C        GTC + V +++C+C P
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPP 1676

Query: 953  GYTGAH--------------------------------------CQHEADPCLSRPCLH- 973
             Y   +                                      C +      ++PC   
Sbjct: 1677 DYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQC 1736

Query: 974  --------GGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQTGAY-C 1022
                      +C +  PGF    ++ +TG      +D C   P  C+NG      G++ C
Sbjct: 1737 PIPSTDEFATLCGSQRPGF---VIDIYTGLPVD--IDECREIPGVCENGVCINMVGSFRC 1791

Query: 1023 LCPPGW----------------SGRLCDIRSLPCREAAAQI------GVRLEQL------ 1054
             CP G+                +G +C  R+  C   A         G R          
Sbjct: 1792 ECPVGFFYNDKLLVCEDIDECQNGPVCQ-RNAECINTAGSYRCDCKPGYRFTSTGQCNDR 1850

Query: 1055 --CQ------AGGQCVDEDSSHYCVCPEGRTGSHCEQ---EVDPCLAQPCQHGGTCRGYM 1103
              CQ      + GQC+D   S YC+C  G   +  +    +++ C    C + GTCR  +
Sbjct: 1851 NECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGN-GTCRNTI 1909

Query: 1104 GGYMCECLPGYNGDNCED--DVDECAS---QPCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
            G + C C  G+   +  D  DVDECAS     C++ G CI+ V  + C C  G      E
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRN-GQCINTVGSFQCQCNEG-----YE 1963

Query: 1159 INED--DCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT--GLRCEADINE------ 1208
            +  D   C         PR    GTC +L G +RC CPPGY+    +CE DI+E      
Sbjct: 1964 VAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCE-DIDECVEEPE 2022

Query: 1209 -CRSGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRCQTV-LSPCESQPCQHGGQCR 1262
             C  G C          +  G F+CLC  GF    SG RCQ + +S C ++    GG+C 
Sbjct: 2023 ICALGTC---------SNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAK--FEGGKC- 2070

Query: 1263 PSPGPGGGLTFTCHCA--QPFWGPRCERVARSCREL---QCPVGV--------------- 1302
             SP         C CA     WG  CE       E     CP G                
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 1303 ----------PCQQTPRGPRCACPPG--LSGPSCRSFPGSPPGASNASCAAAPCLHGGSC 1350
                       C  T    RC CP G  L+G  C              C+       G+C
Sbjct: 2131 CKEPDVCKHGQCINTDGSYRCECPFGYILAGNEC---------VDTDECSVGNPCGNGTC 2181

Query: 1351 RPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRC 1401
            +   +   F C C +G+            E ++ P      C    G   C
Sbjct: 2182 K--NVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYEC 2230



 Score =  396 bits (1017), Expect = e-109
 Identities = 473/1761 (26%), Positives = 665/1761 (37%), Gaps = 376/1761 (21%)

Query: 14   PMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVG 73
            P  P  PPPP+  +P +L +  PG    P +   P          PSRE   + P   V 
Sbjct: 396  PGRPEYPPPPLGPIPPVLPVP-PGFPPGPQI---PVPRPPVEYLYPSREPPRVLPVN-VT 450

Query: 74   ERCQL-EDPCHSGPCAGR-GVCQSSVVAGTARFSCRCPRGF----RGPDCSLPDPCLSSP 127
            + CQL    C +G C    G C+           C C +GF    RG +C   D C  +P
Sbjct: 451  DYCQLVRYLCQNGRCIPTPGSCR-----------CECNKGFQLDLRG-ECIDVDECEKNP 498

Query: 128  CAHGARCSVGPDGRFLCSCPPGYQGRSCRS---DVDECRVGEPCRHGGTCLNTPGSFRCQ 184
            CA G  C +   G + C C  GYQ    R+   D+DEC       + G C+NT GSF C 
Sbjct: 499  CA-GGEC-INNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCV 556

Query: 185  CPAGY----TGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGF----EGQNC-EV 235
            C AG+     G  CE+       + C NG    + G  ++ C C PGF    +G+ C ++
Sbjct: 557  CNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDG--SFKCICKPGFQLASDGRYCKDI 614

Query: 236  NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT----GQFCTEDVDECQLQPNACHNG--- 288
            N  + PG  C+N G CV+   +Y C+C P       G+ C +         + C+ G   
Sbjct: 615  NECETPG-ICMN-GRCVNTDGSYRCECFPGLAVGLDGRVCVD-----THMRSTCYGGYKR 667

Query: 289  GTCFNTLGG------------------------------HSCVCVNGWTGESCSQNIDDC 318
            G C   L G                              +  +C +G    S   +I++C
Sbjct: 668  GQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINEC 727

Query: 319  A--TAVCFHGATCHDRVASFYCACPMG----KTGLLCHLDDACVSNPCHEDAICDTNPVN 372
            A    +C +G  C +   ++ C C  G     TG  C   + CV N      +CD     
Sbjct: 728  ALDPDICPNG-ICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN----SLLCDNGQCR 782

Query: 373  ---GRAICTCPPGFTG----GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTG 425
               G  +CTCP GF        C +D+DEC   ++PC + G C N+ GSF+C+C    T 
Sbjct: 783  NTPGSFVCTCPKGFIYKPDLKTC-EDIDECE--SSPCIN-GVCKNSPGSFICECSSESTL 838

Query: 426  PRCETDVNECLSGPC------------RNQAT----CLDRIG----------QFTCICMA 459
               +T   E + G C             N AT    C   +G          Q   IC  
Sbjct: 839  DPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGK 898

Query: 460  GFT---GTYCEVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSG----------------- 498
            G++   GT CE DIDEC+  P V   G+C +    F C CPSG                 
Sbjct: 899  GYSRIKGTQCE-DIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLET 957

Query: 499  ----FSGSTCQLDV-------------------DECASTPCRNGAKCVDQ-PDGYECRCA 534
                +    C L +                   +EC   P RN  +  +  P G      
Sbjct: 958  CFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATK 1017

Query: 535  EGFEGTLCDRNVDDCS--PDPCHHGRCVDGIASFSCACAPGY---TGTRCESQVDECRSQ 589
            E   G    +++++C   P  C HG+C + I SF C C  G+   +  R  + +DECR  
Sbjct: 1018 EITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRIS 1077

Query: 590  PCRHG-GKCLDLVDKYLCRCPSGTTG-----VNCEVNIDDCASNP--CTFGVCRDGINRY 641
            P   G G+C++    + C+C  G         NC ++ID+C  +P  C  GVC +    Y
Sbjct: 1078 PDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNC-MDIDECQRDPLLCRGGVCHNTEGSY 1136

Query: 642  DCVCQPGF-TGPLCN--VEINEC-ASSPCGEGGSCVDGENGFRCLCPPG--SLPP--LCL 693
             C C PG    P  +  ++INEC  S+     G CV+    ++C C PG  S P    C+
Sbjct: 1137 RCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCV 1196

Query: 694  PPSHPCAHEPCSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARDACESQP-CRAGGTCSS 751
                           C ++ G + C C+PG++  P        D CE  P    GG C++
Sbjct: 1197 DIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTN 1256

Query: 752  DGMGFHCTCPPGVQG----RQCELLSPC--TPNPCEHGGRCESAPGQLPVCSCPQGWQGP 805
                + C C  G       + C  ++ C   PN C   G CE+  G   +C C  G+ G 
Sbjct: 1257 IPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNIC-LSGTCENTKGSF-ICHCDMGYSGK 1314

Query: 806  RCQ---QDVDEC-AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD-QDINDCD--PNPC 858
            + +    D++EC  G   CG H +CTN AGSF C+C  G+ G      D+++C    + C
Sbjct: 1315 KGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMC 1374

Query: 859  LNGGSCQDGVGSFSCSCLPGFAGPR-CARDVDECLS--NPCGPGTCTDHVASFTCTCPPG 915
                 C++ +GS+ C C  G+ G      D+DEC    N CG G C +    + C C  G
Sbjct: 1375 SQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMG 1434

Query: 916  Y----GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHCQHEADPCL 967
            +     G  CE D+ +CS  +    GTC +    F C C  GY    +G +C  + + CL
Sbjct: 1435 FVPSADGKACE-DIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCT-DVNECL 1492

Query: 968  SRPCLHGGVCSAAHPGFRCTCLESF-TGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPP 1026
                   G C      + C C   F   P     VD          G C       + P 
Sbjct: 1493 DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVD-------TRSGNCYLD----IRPR 1541

Query: 1027 GWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQ--------CVDEDSSHYCVCPEGRTG 1078
            G +G         C      +GV     C + G+        C   ++S Y +   G  G
Sbjct: 1542 GDNG------DTACSNEIG-VGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEG 1594

Query: 1079 SHCE------QEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY--NGDN--CEDDVDEC 1126
                      +++D C   P  CQ GG C    G + C C  GY  N D   C DDV+EC
Sbjct: 1595 FRPNPITVILEDIDECQELPGLCQ-GGKCINTFGSFQCRCPTGYYLNEDTRVC-DDVNEC 1652

Query: 1127 ASQPCQHGGSCIDLVARYLCSCPPGTLGV------------LCEIN---EDDCGPGPPLD 1171
             +      G+C + V  Y C CPP  + V            LC  N   ++    G  L 
Sbjct: 1653 ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLF 1712

Query: 1172 SGPR----CLH------NGTC----VDLVGGFRCTC---PPG-----YTGLRCEADINEC 1209
            +  +    C +      N  C    +     F   C    PG     YTGL    DI+EC
Sbjct: 1713 NMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGL--PVDIDEC 1770

Query: 1210 RS--GACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV---LSPCESQP-CQHGGQCRP 1263
            R   G C      + +    G FRC C  GF       V   +  C++ P CQ   +C  
Sbjct: 1771 REIPGVCENGVCINMV----GSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECIN 1826

Query: 1264 SPG-------PGGGLTFTCHCAQPFWGPRCERVARSCRELQC--PVG------------- 1301
            + G       PG   T T  C        C+ +   C   QC   VG             
Sbjct: 1827 TAGSYRCDCKPGYRFTSTGQCND---RNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTN 1883

Query: 1302 ---VPCQQTPRGPRCACPPG-----LSGPSCRSFPGSPPGASNASCAAAPCL--HGGSCR 1351
                 C       R AC  G     +   +CR   G     +N       C   +G  CR
Sbjct: 1884 DDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCR 1943

Query: 1352 PAP---LAPFFRCACAQGW-TGPRCEAPAAAPEVSEEPR-CPRAACQAKRGDQRCDRECN 1406
                      F+C C +G+   P         E   EPR C    CQ   G  RC     
Sbjct: 1944 NGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC---IC 2000

Query: 1407 SPGCGWDGGDC---SLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGR 1463
             PG       C      V +P   C    C    +N+     C  P    + F   + GR
Sbjct: 2001 PPGYSLQNEKCEDIDECVEEP-EICALGTC----SNTEGSFKCLCP----EGFSLSSSGR 2051

Query: 1464 ERTCNPVYEKYCADHFADGRC 1484
               C  +   YC   F  G+C
Sbjct: 2052 R--CQDLRMSYCYAKFEGGKC 2070



 Score =  378 bits (970), Expect = e-104
 Identities = 465/1728 (26%), Positives = 653/1728 (37%), Gaps = 387/1728 (22%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVGE----RCQLEDPCHSGPCAGRGVCQSS-- 96
            C+  S   + G+C   P     C CP G++ +     C+  D C S PC   GVC++S  
Sbjct: 769  CVLNSLLCDNGQCRNTPG-SFVCTCPKGFIYKPDLKTCEDIDECESSPCIN-GVCKNSPG 826

Query: 97   -----------------VVAGTARFSC-------RCPRGFRGPD-----CSLPDPCLSSP 127
                             +   T + +C       RC     G       CS       SP
Sbjct: 827  SFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSP 886

Query: 128  CAHGARCSVGPDGRFLCSCPPGY---QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ 184
            C     C V P       C  GY   +G  C  D+DEC V       G C+NT GSF+CQ
Sbjct: 887  CT---LCQVDP------ICGKGYSRIKGTQCE-DIDECEVFPGVCKNGLCVNTRGSFKCQ 936

Query: 185  CPAGY----TGPLC--------------ENPAVP---------CAPSPCRNGGT-----C 212
            CP+G     TG +C              E   +P         C  S     GT     C
Sbjct: 937  CPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEEC 996

Query: 213  RQSGDLTYD--CACLPGF------EGQNCEVNVDDCPGHRCL-NGGTCVDGVNTYNCQCP 263
                   Y+  C   PGF       G+    ++++C     L   G C + + ++ C+C 
Sbjct: 997  PMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCD 1056

Query: 264  PEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTG-----ESCSQN 314
              +      + CT D+DEC++ P+ C   G C NT G   C C  G+       ++C  +
Sbjct: 1057 SGFALDSEERNCT-DIDECRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMMKNC-MD 1113

Query: 315  IDDC-ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS-NPCHEDA-ICDTNPV 371
            ID+C    +   G  CH+   S+ C CP G    L     AC+  N C   A +C     
Sbjct: 1114 IDECQRDPLLCRGGVCHNTEGSYRCECPPGHQ--LSPNISACIDINECELSAHLCP---- 1167

Query: 372  NGRAI-------CTCPPGFTGGA----CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG 420
            NGR +       C C PG+        C  D+DECSI    CE    C N++GS+ C C 
Sbjct: 1168 NGRCVNLIGKYQCACNPGYHSTPDRLFC-VDIDECSIMNGGCETF--CTNSEGSYECSCQ 1224

Query: 421  RGYT---GPRCETDVNECLSGP-CRNQATCLDRIGQFTCICMAGFTGT----YCEVDIDE 472
             G+      R  TD++EC   P   +   C +  G++ C+C  GF  +     C VD++E
Sbjct: 1225 PGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTC-VDVNE 1283

Query: 473  CQSSP--CVNGGVCKDRVNGFSCTCPSGFS---GSTCQLDVDEC--ASTPCRNGAKCVDQ 525
            C  +P  C++ G C++    F C C  G+S   G T   D++EC   +  C   A C + 
Sbjct: 1284 CDLNPNICLS-GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNT 1342

Query: 526  PDGYECRCAEGF--EGTLCDRNVDDCSPDP---CHHGRCVDGIASFSCACAPGYTGT--R 578
               ++C C+ G+  +G  C  ++D+CS        H  C + + S+ C C  GYTG    
Sbjct: 1343 AGSFKCSCSPGWIGDGIKC-TDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFT 1401

Query: 579  CESQVDECRSQPCRHG-GKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCA-SNPCTFG 632
            C + +DEC       G G+CL+    Y C C  G      G  CE +ID+C+  N C FG
Sbjct: 1402 C-TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACE-DIDECSLPNICVFG 1459

Query: 633  VCRDGINRYDCVCQPGF----TGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSL 688
             C +    + C C+ G+    +G  C  ++NEC        G+CV+    + C CP    
Sbjct: 1460 TCHNLPGLFRCECEIGYELDRSGGNC-TDVNECLDPTTCISGNCVNTPGSYICDCP---- 1514

Query: 689  PPLCLPPSHPCAHEPCSHGICY------DAPGGFRCVCEPGWSGPRCSQSLARDACESQP 742
            P   L P+     +  S G CY         G   C  E G    + S   +       P
Sbjct: 1515 PDFELNPTRVGCVDTRS-GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTP 1573

Query: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQ-------CELLSPC--TPNPCEHGGRCESAPGQL 793
            C      ++      C   PG +G +        E +  C   P  C+ GG+C +  G  
Sbjct: 1574 CEMCPAVNTSEYKILC---PGGEGFRPNPITVILEDIDECQELPGLCQ-GGKCINTFGSF 1629

Query: 794  PVCSCPQGW---QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT----GPSC 846
              C CP G+   +  R   DV+EC  P  CGP G C N  G+++C C   Y     G +C
Sbjct: 1630 Q-CRCPTGYYLNEDTRVCDDVNECETPGICGP-GTCYNTVGNYTCICPPDYMQVNGGNNC 1687

Query: 847  -DQDINDCDPNPCLNGGSCQDGVGSFS-----CSC------------------------- 875
             D   + C  N   +  +C DG   F+     C C                         
Sbjct: 1688 MDMRRSLCYRNYYADNQTC-DGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFAT 1746

Query: 876  -----LPGFA---GPRCARDVDECLSNP--CGPGTCTDHVASFTCTCPPGYGGFHCE--- 922
                  PGF          D+DEC   P  C  G C + V SF C CP G+  F+ +   
Sbjct: 1747 LCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGF--FYNDKLL 1804

Query: 923  --QDLPDCSPSS-CFNGGTCVDGVNSFSCLCRPGY--TGAHCQHEADPCLSRP--CLHGG 975
              +D+ +C     C     C++   S+ C C+PGY  T     ++ + C   P  C H G
Sbjct: 1805 VCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSH-G 1863

Query: 976  VCSAAHPGFRCTCLESFTGPQCQTL---VDWCSRQPCQNGGRCVQTGAY-CLCPPGW--- 1028
             C      F C C   F     QT+   ++ C R  C NG      G++ C C  G+   
Sbjct: 1864 QCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILS 1923

Query: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG----RTGSHCEQE 1084
                C    +   E A+  G     LC+  GQC++   S  C C EG      G  C  +
Sbjct: 1924 HNNDC----IDVDECASGNG----NLCR-NGQCINTVGSFQCQCNEGYEVAPDGRTC-VD 1973

Query: 1085 VDPCLAQPCQHG-GTCRGYMGGYMCECLPGYN--GDNCEDDVDECASQP--CQHGGSCID 1139
            ++ CL +P +   GTC+   G Y C C PGY+   + CE D+DEC  +P  C   G+C +
Sbjct: 1974 INECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCE-DIDECVEEPEICAL-GTCSN 2031

Query: 1140 LVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRC--LHNGTCVDLVGGFRCTCPPGY 1197
                + C CP G                    SG RC  L    C     G +C+ P   
Sbjct: 2032 TEGSFKCLCPEGF---------------SLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSR 2076

Query: 1198 TGLR---CEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAG---FSGPRCQTV-LSPC 1250
               +   C A   E     C       C  +P   FR +C  G     GP    V +  C
Sbjct: 2077 NHSKQECCCALKGEGWGDPCEL-----CPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC 2131

Query: 1251 -ESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW----GPRCERVARSCRELQCPVGVPCQ 1305
             E   C+H GQC  + G     ++ C C  PF     G  C          +C VG PC 
Sbjct: 2132 KEPDVCKH-GQCINTDG-----SYRCEC--PFGYILAGNECVDTD------ECSVGNPCG 2177

Query: 1306 QTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQ 1365
                     C   + G  C    G  PG          C     C   PL   FRC    
Sbjct: 2178 NG------TCKNVIGGFECTCEEGFEPG------PMMTCEDINECAQNPLLCAFRCVNTY 2225

Query: 1366 GWTGPRCEAPAAAPE----VSEEPRC---------PRAACQAKRGDQRC------DRECN 1406
            G    +C       E      +E  C          +  C+   G   C       R  +
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPD 2285

Query: 1407 SPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRC---DPACSSP---ACLYDNFD--- 1457
              GC  D  +C    G     CE  +C     +  C   D   +SP    CL DN +   
Sbjct: 2286 GEGC-VDENECQTKPG----ICENGRCLNTRGSYTCECNDGFTASPNQDECL-DNREGYC 2339

Query: 1458 --------CHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDG 1497
                    C  G   R  NPV +  C     DG    G + E C + G
Sbjct: 2340 FTEVLQNMCQIGSSNR--NPVTKSECC---CDGGRGWGPHCEICPFQG 2382



 Score =  375 bits (964), Expect = e-103
 Identities = 427/1600 (26%), Positives = 587/1600 (36%), Gaps = 358/1600 (22%)

Query: 60   SREAACLCPPGWVGERCQLEDPCHSG-PCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS 118
            SR   C CP G +   C      H    C   G C            C C +G+ G  C 
Sbjct: 95   SRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD--------HCLCQKGYIGTHCG 146

Query: 119  LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPC---------- 168
               P   S C +G RC V P+    C+C  G+ G  C  D    R G PC          
Sbjct: 147  --QPVCESGCLNGGRC-VAPN---RCACTYGFTGPQCERDY---RTG-PCFTVISNQMCQ 196

Query: 169  --RHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP 226
                G  C  T     C       G  CE    P  P PCR G               +P
Sbjct: 197  GQLSGIVCTKT---LCCATVGRAWGHPCE--MCPAQPHPCRRG--------------FIP 237

Query: 227  GFEGQNCEVNVDDC---PGHRCLNGGTCVDGVNTYNCQCPP----EWTGQFCTEDVDECQ 279
                  C+ +VD+C   PG     GG C++ V ++ C+CP         Q C ED+DEC 
Sbjct: 238  NIRTGACQ-DVDECQAIPG--LCQGGNCINTVGSFECKCPAGHKLNEVSQKC-EDIDECS 293

Query: 280  LQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT---CHDR---- 332
              P  C  GG C NT+  + C C  G+          D     C+   T   C ++    
Sbjct: 294  TIPGIC-EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQS 352

Query: 333  VASFYCACPMGKTGLLCHLDDACVS-NPCHEDAICDTNP-------VNGR---------- 374
            +    C C  G+    C      V+   C   A  D N        + GR          
Sbjct: 353  ITKMQCCCDAGR----CWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPEYPPPPLGP 408

Query: 375  --AICTCPPGFTGG----------------------ACDQDVDECSIGANPCEHLGRCVN 410
               +   PPGF  G                            D C +    C++ GRC+ 
Sbjct: 409  IPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQN-GRCIP 467

Query: 411  TQGSFLCQCGRGY---TGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGF----TG 463
            T GS  C+C +G+       C  DV+EC   PC     C++  G +TC C AG+    T 
Sbjct: 468  TPGSCRCECNKGFQLDLRGEC-IDVDECEKNPCAG-GECINNQGSYTCQCRAGYQSTLTR 525

Query: 464  TYCEVDIDEC-QSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECA-STPCR 517
            T C  DIDEC Q+    N G C +    F C C +GF     G  C+ D+DEC+    C 
Sbjct: 526  TECR-DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCE-DMDECSIRNMCL 583

Query: 518  NGAKCVDQPDGYECRCAEGF----EGTLCDRNVDDC-SPDPCHHGRCVDGIASFSCACAP 572
            NG  C+++   ++C C  GF    +G  C +++++C +P  C +GRCV+   S+ C C P
Sbjct: 584  NG-MCINEDGSFKCICKPGFQLASDGRYC-KDINECETPGICMNGRCVNTDGSYRCECFP 641

Query: 573  GY-TGTRCESQVDECRSQPCRHG---GKCLDLV--------------------------- 601
            G   G      VD      C  G   G+C+  +                           
Sbjct: 642  GLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPA 701

Query: 602  ---DKYLCRCPSGTTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGF----TGP 652
                +Y   C SG    +   +I++CA +P  C  G+C +    Y C+C  G+    TG 
Sbjct: 702  QNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGK 761

Query: 653  LCNVEINECA-SSPCGEGGSCVDGENGFRCLCPPGSL--PPL-CLPPSHPCAHEPCSHGI 708
             C V+INEC  +S   + G C +    F C CP G +  P L        C   PC +G+
Sbjct: 762  NC-VDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGV 820

Query: 709  CYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRA-GGTCSSDGMGFHCTC---PPGV 764
            C ++PG F C          CS     D  ++       GTC    +   C        +
Sbjct: 821  CKNSPGSFIC---------ECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATL 871

Query: 765  QGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGW---QGPRCQQDVDEC-AGPAPC 820
            + + C  L     +PC     C+  P       C +G+   +G +C +D+DEC   P  C
Sbjct: 872  KSQCCSSLGAAWGSPCT---LCQVDP------ICGKGYSRIKGTQC-EDIDECEVFPGVC 921

Query: 821  GPHGICTNLAGSFSCTCHGGY----TGPSC-DQDINDC----DPNPC---------LNGG 862
              +G+C N  GSF C C  G     TG  C D  +  C    +   C         ++  
Sbjct: 922  -KNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDAC 980

Query: 863  SCQDGVGSFSCSCL-----------------PGFA------GPRCARDVDECLSNP--CG 897
             C  G    +  C                  PGFA      G    +D++EC   P  C 
Sbjct: 981  CCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCT 1040

Query: 898  PGTCTDHVASFTCTCPPGYGGFHCEQ---DLPDC--SPSSCFNGGTCVDGVNSFSCLCRP 952
             G C + + SF C C  G+     E+   D+ +C  SP  C   G CV+    F C C  
Sbjct: 1041 HGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPGDFECKCDE 1099

Query: 953  GYTGA-----HCQHEADPCLSRPCL-HGGVCSAAHPGFRCTCLESF-TGPQCQTLVD--- 1002
            GY        +C  + D C   P L  GGVC      +RC C       P     +D   
Sbjct: 1100 GYESGFMMMKNCM-DIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINE 1158

Query: 1003 -WCSRQPCQNGGRCVQ-TGAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGG 1059
               S   C N GRCV   G Y C C PG+        S P R     I    E     GG
Sbjct: 1159 CELSAHLCPN-GRCVNLIGKYQCACNPGY-------HSTPDRLFCVDID---ECSIMNGG 1207

Query: 1060 ---QCVDEDSSHYCVCPEG---RTGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECL 1111
                C + + S+ C C  G           ++D C   P  C  GG C    G Y C C 
Sbjct: 1208 CETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICD-GGQCTNIPGEYRCLCY 1266

Query: 1112 PGYNGDNCED-----DVDECASQP--CQHGGSCIDLVARYLCSCPPGTLGV-----LCEI 1159
             G+     ED     DV+EC   P  C   G+C +    ++C C  G  G        +I
Sbjct: 1267 DGFMAS--EDMKTCVDVNECDLNPNICL-SGTCENTKGSFICHCDMGYSGKKGKTGCTDI 1323

Query: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY--TGLRCEADINECRSGACHAA 1217
            NE + G          C  +  C +  G F+C+C PG+   G++C  D++EC +G    +
Sbjct: 1324 NECEIG-------AHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKC-TDLDECSNGTHMCS 1375

Query: 1218 HTRDCLQDPGGGFRCLCHAGFSGP--RCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275
               DC ++  G +RCLC  G++G    C  +    E+      GQC  +PG      + C
Sbjct: 1376 QHADC-KNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPG-----GYRC 1429

Query: 1276 HCAQPFW----GPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGL----SGPSCRSF 1327
             C   F     G  CE +        C  G  C   P   RC C  G     SG +C   
Sbjct: 1430 ECDMGFVPSADGKACEDIDECSLPNICVFGT-CHNLPGLFRCECEIGYELDRSGGNCTDV 1488

Query: 1328 PG--SPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEP 1385
                 P    + +C   P  +   C P       R  C    +G  C        +   P
Sbjct: 1489 NECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSG-NC-------YLDIRP 1540

Query: 1386 RCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPW 1425
            R          GD  C  E    G G     C  S+G  W
Sbjct: 1541 R-------GDNGDTACSNEI---GVGVSKASCCCSLGKAW 1570



 Score =  249 bits (637), Expect = 2e-65
 Identities = 346/1448 (23%), Positives = 487/1448 (33%), Gaps = 402/1448 (27%)

Query: 337  YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGAC-DQDVDEC 395
            YC CP  KT       + C+   C     C     +   +CTCP G    +C  + +  C
Sbjct: 66   YC-CPGWKT---LPGGNQCIVPICRHS--CGDGFCSRPNMCTCPSGQIAPSCGSRSIQHC 119

Query: 396  SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
            +I    C + G C +      C C +GY G  C   V  C SG C N   C   +    C
Sbjct: 120  NIR---CMNGGSCSDDH----CLCQKGYIGTHCGQPV--CESG-CLNGGRC---VAPNRC 166

Query: 456  ICMAGFTGTYCEVDIDECQSSPC---VNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECA 512
             C  GFTG  CE D    ++ PC   ++  +C+ +++G  CT       + C   V    
Sbjct: 167  ACTYGFTGPQCERDY---RTGPCFTVISNQMCQGQLSGIVCT------KTLCCATVGRAW 217

Query: 513  STPCRNGAKCVDQPDGYECRCAEGFEGTL---CDRNVDDCSPDP--CHHGRCVDGIASFS 567
              PC     C  QP      C  GF   +     ++VD+C   P  C  G C++ + SF 
Sbjct: 218  GHPCE---MCPAQPHP----CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFE 270

Query: 568  CACAPGY----TGTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSG----TTGVNC 617
            C C  G+       +CE  +DEC + P  C  GG+C + V  Y C+CP G      G  C
Sbjct: 271  CKCPAGHKLNEVSQKCED-IDECSTIPGICE-GGECTNTVSSYFCKCPPGFYTSPDGTRC 328

Query: 618  -EVNIDDCASNPCTFGVCRD----GINRYDCVC------QPGFT--------------GP 652
             +V    C +   T G C +     I +  C C       PG T                
Sbjct: 329  IDVRPGYCYT-ALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNK 387

Query: 653  LCNVEI-----NECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPP---SHPCAHEP- 703
            LC+V +      E    P G     +    GF    PPG   P+  PP    +P    P 
Sbjct: 388  LCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGF----PPGPQIPVPRPPVEYLYPSREPPR 443

Query: 704  ----------------CSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG 747
                            C +G C   PG  RC C  G+      + +  D CE  PC AGG
Sbjct: 444  VLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPC-AGG 502

Query: 748  TCSSDGMGFHCTCPPGVQG----RQCELLSPCTPNP--CEHGGRCESAPGQLPVCSCPQG 801
             C ++   + C C  G Q      +C  +  C  N   C + GRC +  G    C C  G
Sbjct: 503  ECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRIC-NNGRCINTDGSFH-CVCNAG 560

Query: 802  W----QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDC 853
            +     G  C +D+DEC+    C  +G+C N  GSF C C  G+     G  C +DIN+C
Sbjct: 561  FHVTRDGKNC-EDMDECSIRNMC-LNGMCINEDGSFKCICKPGFQLASDGRYC-KDINEC 617

Query: 854  D-PNPCLNGGSCQDGVGSFSCSCLPGFA-------------------------------- 880
            + P  C+N G C +  GS+ C C PG A                                
Sbjct: 618  ETPGICMN-GRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676

Query: 881  ----GPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCS--PSSCF 934
                   C    +     PC P     + A +   C  G G      D+ +C+  P  C 
Sbjct: 677  AVTKSECCCASTEYAFGEPCQP-CPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICP 735

Query: 935  NGGTCVDGVNSFSCLCRPGY----TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLE 990
            N G C +   ++ C+C  GY    TG +C    +  L+      G C      F CTC +
Sbjct: 736  N-GICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPK 794

Query: 991  SFT-GPQCQTL--VDWCSRQPCQNG-------------------------------GRCV 1016
             F   P  +T   +D C   PC NG                               G C 
Sbjct: 795  GFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCW 854

Query: 1017 QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIG-----VRLEQLCQAG------------- 1058
            QT     C    +G    ++S  C    A  G      +++ +C  G             
Sbjct: 855  QTVIDGRCEINING--ATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDID 912

Query: 1059 -----------GQCVDEDSSHYCVCPEG----RTGSHC-EQEVDPCLA----QPCQHGGT 1098
                       G CV+   S  C CP G     TG  C +  ++ C      + C     
Sbjct: 913  ECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIA 972

Query: 1099 CRGYMGGYMCECLPGYNGDNCED--------------------------------DVDEC 1126
             R  M    C     +  + CE+                                D++EC
Sbjct: 973  GRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINEC 1032

Query: 1127 ASQP--CQHGGSCIDLVARYLCSCPPG----------TLGVLCEINEDDCGPG----PPL 1170
               P  C H G C + +  + C C  G          T    C I+ D CG G     P 
Sbjct: 1033 KMIPSLCTH-GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPG 1091

Query: 1171 DSGPRC--------LHNGTCVDL------------------VGGFRCTCPPGY---TGLR 1201
            D   +C        +    C+D+                   G +RC CPPG+     + 
Sbjct: 1092 DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNIS 1151

Query: 1202 CEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGP-----------------RCQ 1244
               DINEC   A H      C+ +  G ++C C+ G+                     C+
Sbjct: 1152 ACIDINECELSA-HLCPNGRCV-NLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCE 1209

Query: 1245 TVLS------PCESQP----------CQHGGQCRPSPG--PGGGLT-----FTCHCAQPF 1281
            T  +       C  QP          C    +C  +P    GG  T     + C C   F
Sbjct: 1210 TFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGF 1269

Query: 1282 WGPRCERVARSCRELQCPVGV----PCQQTPRGPRCACPPGLSG----PSCRSFPGSPPG 1333
                  +      E      +     C+ T     C C  G SG      C        G
Sbjct: 1270 MASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIG 1329

Query: 1334 ASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPR-AAC 1392
            A N    A      GS         F+C+C+ GW G   +        +    C + A C
Sbjct: 1330 AHNCGKHAVCTNTAGS---------FKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADC 1380

Query: 1393 QAKRGDQRCDRECNSPGCGW---DGGDCSLSVGDPWRQCEALQCWRLFNNSRCD------ 1443
            +   G  RC  +    G G+   D  +CS ++      C   QC       RC+      
Sbjct: 1381 KNTMGSYRCLCKEGYTGDGFTCTDLDECSENL----NLCGNGQCLNAPGGYRCECDMGFV 1436

Query: 1444 PACSSPAC 1451
            P+    AC
Sbjct: 1437 PSADGKAC 1444



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 142/568 (25%), Positives = 191/568 (33%), Gaps = 147/568 (25%)

Query: 976  VCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDI 1035
            VC + +  + C   ++  G   Q +V  C R  C +G  C +    C CP G     C  
Sbjct: 58   VCGSRYNAYCCPGWKTLPGGN-QCIVPIC-RHSCGDGF-CSRPNM-CTCPSGQIAPSCGS 113

Query: 1036 RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQH 1095
            RS+          +R    C  GG C D+    +C+C +G  G+HC Q   P     C +
Sbjct: 114  RSIQ------HCNIR----CMNGGSCSDD----HCLCQKGYIGTHCGQ---PVCESGCLN 156

Query: 1096 GGTCRGYMGGYMCECLPGYNGDNCEDD--VDEC----ASQPCQHGGSCIDLVARYLCS-- 1147
            GG C   +    C C  G+ G  CE D     C    ++Q CQ   S I       C+  
Sbjct: 157  GGRC---VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATV 213

Query: 1148 ----------CP----PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
                      CP    P   G +  I    C       + P     G C++ VG F C C
Sbjct: 214  GRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKC 273

Query: 1194 PPGY----TGLRCEADINECRS--GACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRC 1243
            P G+       +CE DI+EC +  G C      + +      + C C  GF     G RC
Sbjct: 274  PAGHKLNEVSQKCE-DIDECSTIPGICEGGECTNTV----SSYFCKCPPGFYTSPDGTRC 328

Query: 1244 QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHC-AQPFWGPRCERVARSC--------- 1293
              V  P         G+C  +  P       C C A   W P        C         
Sbjct: 329  IDV-RPGYCYTALTNGRC-SNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFN 386

Query: 1294 RELQCPVGVPCQ-QTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP 1352
            +    P+ +P + + P  P    PP L  P     PG PPG                  P
Sbjct: 387  KLCSVPMVIPGRPEYPPPPLGPIPPVLPVP-----PGFPPGPQ---------------IP 426

Query: 1353 APLAPFFRCACAQGWTGPRCEAPAAAP-EVSEEPRCPRAACQAKR-----GDQRCD---- 1402
             P  P         +  P  E P   P  V++  +  R  CQ  R     G  RC+    
Sbjct: 427  VPRPPV-------EYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKG 479

Query: 1403 ------------RECNSPGCGWDGGDCSLSVGDPWRQC-----------------EALQC 1433
                         EC    C   GG+C  + G    QC                 E LQ 
Sbjct: 480  FQLDLRGECIDVDECEKNPCA--GGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQN 537

Query: 1434 WRLFNNSRCDPACSSPACLYDNFDCHAG 1461
             R+ NN RC     S  C+     C+AG
Sbjct: 538  GRICNNGRCINTDGSFHCV-----CNAG 560



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 100/364 (27%), Positives = 129/364 (35%), Gaps = 106/364 (29%)

Query: 141 RFLCSCPPGYQ----GRSCRSDVDECRVGEPCRHG---GTCLNTPGSFRCQCPAGYTGPL 193
           R+   C PG++    G  C   +        CRH    G C + P    C CP+G   P 
Sbjct: 62  RYNAYCCPGWKTLPGGNQCIVPI--------CRHSCGDGFC-SRPNM--CTCPSGQIAPS 110

Query: 194 CENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVD 253
           C + ++      C NGG+C         C C  G+ G +C   V +     CLNGG C  
Sbjct: 111 CGSRSIQHCNIRCMNGGSCSDD-----HCLCQKGYIGTHCGQPVCE---SGCLNGGRC-- 160

Query: 254 GVNTYNCQCPPEWTGQFCTEDV-----------DECQLQPNACHNGGT-CFNTLG---GH 298
            V    C C   +TG  C  D              CQ Q +      T C  T+G   GH
Sbjct: 161 -VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGH 219

Query: 299 SC--------VCVNGWTGE---SCSQNIDDC-ATAVCFHGATCHDRVASFYCACPMGKTG 346
            C         C  G+         Q++D+C A      G  C + V SF C CP G   
Sbjct: 220 PCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGH-- 277

Query: 347 LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLG 406
               L++  VS  C +   C T P               G C+                G
Sbjct: 278 ---KLNE--VSQKCEDIDECSTIP---------------GICEG---------------G 302

Query: 407 RCVNTQGSFLCQCGRG-YTGP---RCETDV------NECLSGPCRNQATCLDRIGQFTCI 456
            C NT  S+ C+C  G YT P   RC  DV          +G C NQ      I +  C 
Sbjct: 303 ECTNTVSSYFCKCPPGFYTSPDGTRC-IDVRPGYCYTALTNGRCSNQLP--QSITKMQCC 359

Query: 457 CMAG 460
           C AG
Sbjct: 360 CDAG 363


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  443 bits (1139), Expect = e-123
 Identities = 240/655 (36%), Positives = 318/655 (48%), Gaps = 64/655 (9%)

Query: 123 CLS-SPCAHGARC---SVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTP 178
           CL+  PC +G +C    V  +  + CSC  G+ GR C  DV+EC   +PC++GGTC +  
Sbjct: 272 CLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNEC-ASQPCQNGGTCTHGI 330

Query: 179 GSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCR-QSGDLTYDCACLPGFEGQNCEVNV 237
            SFRCQCPAG+ GP CE    PC    C++GG C+ ++G     C C  G+ G  CE++V
Sbjct: 331 NSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAV--CVCQAGYTGAACEMDV 388

Query: 238 DDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC-TED---VDECQLQPNACHNGGTCFN 293
           DDC    CLNGG+CVD V  Y C C   + G  C T D    D C   P  CHNGGTC +
Sbjct: 389 DDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAP--CHNGGTCVD 446

Query: 294 TLGGHSCVCVNGWTGESCSQNI-DDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD 352
              G+ C C  G+ G  C + + DDC    C +G  C     +  C CP+G  GLLC  +
Sbjct: 447 ADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLGANTTL-CQCPLGFFGLLCEFE 502

Query: 353 DACVSNPCHEDAICDTNPV----NGRAICTCPPGFTG-----GACDQDVDECSIGANPCE 403
               + PC+ +  C          G  +C C             CD D         PC 
Sbjct: 503 --ITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSD---------PCF 551

Query: 404 HLGRCVNTQGSFLCQCGRGYTGPRCE-TDVNECLSGPCRNQATCLDRIGQFTCICMAGFT 462
           + G C     S+ C+C RG+ G  CE    + C SGPCRN  TC +  G++ C C   FT
Sbjct: 552 NGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFT 611

Query: 463 GTYCEV-DIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAK 521
           G +CE+   D C S PC NGG C   +  + C CP GFSG  C++    C  +PC NG  
Sbjct: 612 GRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGT 671

Query: 522 CVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH------GRCVDGIASFSC------- 568
           C D+   + C C  G+ G  C   VD   P+   H      G  +  +A ++C       
Sbjct: 672 CEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLS 731

Query: 569 ------ACAPGYTGTRCES--QVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVN 620
                  C P    +      ++DECRSQPC HGG C D V  YLC C +G  G +CE+ 
Sbjct: 732 APSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELE 791

Query: 621 IDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 679
            D+C ++PC   G CR+    Y C C  GF G  C  E++ C SSPC  GG C  G   +
Sbjct: 792 RDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAY 851

Query: 680 RCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSL 733
            C+CP       C   S PC   PC   G C  + G   C C+ G++G  C++ L
Sbjct: 852 LCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906



 Score =  438 bits (1127), Expect = e-122
 Identities = 234/653 (35%), Positives = 316/653 (48%), Gaps = 54/653 (8%)

Query: 386 GACDQDVDECSIGANPCEHLGRCVNT----QGSFLCQCGRGYTGPRCETDVNECLSGPCR 441
           G C      C +   PC + G+C++       S+ C C  G+TG RC  DVNEC S PC+
Sbjct: 263 GGCGHTTSVC-LALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQ 321

Query: 442 NQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSG 501
           N  TC   I  F C C AGF G  CE     C +  C +GG C+       C C +G++G
Sbjct: 322 NGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTG 381

Query: 502 STCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRN----VDDCSPDPCHH- 556
           + C++DVD+C+  PC NG  CVD    Y C CAE F+G  C+       D C   PCH+ 
Sbjct: 382 AACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNG 441

Query: 557 GRCVDGIASFSCACAPGYTGTRCESQV-DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGV 615
           G CVD    + C C  G+ G  C  +V D+C    CR+GG+CL   +  LC+CP G  G+
Sbjct: 442 GTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLG-ANTTLCQCPLGFFGL 497

Query: 616 NCEVNIDDCASNPCTF-------GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE 668
            CE  I    + PC         G C +    Y CVC         +   + C S PC  
Sbjct: 498 LCEFEI---TAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNA--SHSLPSPCDSDPCFN 552

Query: 669 GGSCVDGENGFRCLCPPGSLPPLC-LPPSHPCAHEPCSH-GICYDAPGGFRCVCEPGWSG 726
           GGSC   ++ + C CP G     C     H C+  PC + G C +A G + C C   ++G
Sbjct: 553 GGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTG 612

Query: 727 PRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL-SPCTPNPCEHGGR 785
             C      D+C S PC  GGTC      + C CPPG  GR CE+  SPC  +PC +GG 
Sbjct: 613 RHCEIG-KPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGT 671

Query: 786 CESAPGQLPVCSCPQGWQGPRCQQDVDECAGP-----APCGPHGICTNLAGSFSC----- 835
           CE        C C  G+ G RCQ +VD C  P     A    +G        ++C     
Sbjct: 672 CEDRDTDF-FCHCQAGYMGRRCQAEVD-CGPPEEVKHATLRFNGTRLGAVALYACDRGYS 729

Query: 836 --------TC--HGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCA 885
                    C  HG ++ P    +I++C   PCL+GGSCQD V  + C C  G+ G  C 
Sbjct: 730 LSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCE 789

Query: 886 RDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVN 944
            + DEC ++PC   G+C +   ++ C CP G+ G HCE ++  C  S C +GG C  G  
Sbjct: 790 LERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGG 849

Query: 945 SFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQC 997
           ++ C+C   + G HC+  +DPC S PC   G C A++    CTC   +TG  C
Sbjct: 850 AYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902



 Score =  422 bits (1086), Expect = e-117
 Identities = 230/645 (35%), Positives = 296/645 (45%), Gaps = 41/645 (6%)

Query: 589  QPCRHGGKCLDLV----DKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDC 643
            +PC +GGKC+D        Y C C SG TG  C +++++CAS PC   G C  GIN + C
Sbjct: 276  RPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRC 335

Query: 644  VCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEP 703
             C  GF GP C    + C +  C  GG C        C+C  G     C      C+ +P
Sbjct: 336  QCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDP 395

Query: 704  CSHG-ICYDAPGGFRCVCEPGWSGPRCSQS--LARDACESQPCRAGGTCSSDGMGFHCTC 760
            C +G  C D  G + C+C   + G RC        DAC S PC  GGTC     G+ C C
Sbjct: 396  CLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCEC 455

Query: 761  PPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDE--CAGPA 818
            P G  G  C    P     C +GGRC  A   L  C CP G+ G  C+ ++    C    
Sbjct: 456  PEGFMGLDCRERVP-DDCECRNGGRCLGANTTL--CQCPLGFFGLLCEFEITAMPCNMNT 512

Query: 819  PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI-NDCDPNPCLNGGSCQDGVGSFSCSCLP 877
             C   G C    GS+ C CH   T  +    + + CD +PC NGGSC     S++C C  
Sbjct: 513  QCPDGGYCMEHGGSYLCVCH---TDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPR 569

Query: 878  GFAGPRCARDVDE-CLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPD-CSPSSCF 934
            GF G  C +     C S PC   GTC +    + C+CP  + G HCE   PD C+   C 
Sbjct: 570  GFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCH 629

Query: 935  NGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTG 994
            NGGTC   +  + C C PG++G HC+    PC   PC++GG C      F C C   + G
Sbjct: 630  NGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMG 689

Query: 995  PQCQTLVDWCSRQPCQ------NGGRCVQTGAYCLCPPGWSG------RLCDIRSLPCRE 1042
             +CQ  VD    +  +      NG R      Y  C  G+S       R+C    +    
Sbjct: 690  RRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYA-CDRGYSLSAPSRIRVCQPHGVWSEP 748

Query: 1043 AAA-QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRG 1101
                +I     Q C  GG C D  + + C+C  G  G+HCE E D C A PC++GG+CR 
Sbjct: 749  PQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRN 808

Query: 1102 YMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINE 1161
              G Y+C C  G+ G +CE +VD C S PCQHGG C      YLC CP    G  CE   
Sbjct: 809  LPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVS 868

Query: 1162 DDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADI 1206
            D C   P       C   G C+   G   CTC  GYTG  C  ++
Sbjct: 869  DPCFSSP-------CGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906



 Score =  404 bits (1037), Expect = e-112
 Identities = 227/679 (33%), Positives = 316/679 (46%), Gaps = 55/679 (8%)

Query: 173 TCLNTPG--SFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQ---SGDLTYDCACLPG 227
           T +  PG  +FR        G      +V  A  PC NGG C     +G+ +Y C+CL G
Sbjct: 243 TNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSG 302

Query: 228 FEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHN 287
           F G+ C ++V++C    C NGGTC  G+N++ CQCP  + G  C      C  +   C +
Sbjct: 303 FTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTK--ECQH 360

Query: 288 GGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGL 347
           GG C    G   CVC  G+TG +C  ++DDC+   C +G +C D V ++ C C     GL
Sbjct: 361 GGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGL 420

Query: 348 LCH-----LDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDV-DECSIGANP 401
            C      + DAC+S PCH    C     +   +C CP GF G  C + V D+C      
Sbjct: 421 RCETGDHPVPDACLSAPCHNGGTC--VDADQGYVCECPEGFMGLDCRERVPDDCE----- 473

Query: 402 CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNEC---LSGPCRNQATCLDRIGQFTCICM 458
           C + GRC+    + LCQC  G+ G  CE ++      ++  C +   C++  G + C+C 
Sbjct: 474 CRNGGRCLGA-NTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCH 532

Query: 459 AGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE-CASTPCR 517
                ++       C S PC NGG C    + ++C CP GF G  C+      C+S PCR
Sbjct: 533 TDHNASHSLP--SPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCR 590

Query: 518 NGAKCVDQPDGYECRCAEGFEGTLCD-RNVDDCSPDPCHH-GRCVDGIASFSCACAPGYT 575
           NG  C +    Y C C   F G  C+    D C+  PCH+ G C   I  + C C PG++
Sbjct: 591 NGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFS 650

Query: 576 GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNID-----DCASNPCT 630
           G  CE     C   PC +GG C D    + C C +G  G  C+  +D     +       
Sbjct: 651 GRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLR 710

Query: 631 FGVCRDG-INRYDC-------------VCQPG--FTGPLCNVEINECASSPCGEGGSCVD 674
           F   R G +  Y C             VCQP   ++ P   +EI+EC S PC  GGSC D
Sbjct: 711 FNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQD 770

Query: 675 GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSH-GICYDAPGGFRCVCEPGWSGPRCSQSL 733
              G+ CLC  G     C      C   PC + G C + PG + C C  G+ G  C   +
Sbjct: 771 RVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEV 830

Query: 734 ARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLS-PCTPNPCEHGGRCESAPGQ 792
             DAC+S PC+ GG C S G  + C CP    G  CE +S PC  +PC   G C ++ G 
Sbjct: 831 --DACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGS 888

Query: 793 LPVCSCPQGWQGPRCQQDV 811
              C+C  G+ G  C +++
Sbjct: 889 -HSCTCKVGYTGEDCAKEL 906



 Score =  392 bits (1008), Expect = e-108
 Identities = 219/650 (33%), Positives = 289/650 (44%), Gaps = 118/650 (18%)

Query: 428 CETDVNECLS-GPCRNQATCLDRI----GQFTCICMAGFTGTYCEVDIDECQSSPCVNGG 482
           C    + CL+  PC N   C+D        +TC C++GFTG  C +D++EC S PC NGG
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324

Query: 483 VCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC 542
            C   +N F C CP+GF G TC+     C +  C++G +C  +     C C  G+ G  C
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAAC 384

Query: 543 DRNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQ----VDECRSQPCRHGGKC 597
           + +VDDCSPDPC + G CVD + +++C CA  + G RCE+      D C S PC +GG C
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444

Query: 598 LDLVDKYLCRCPSGTTGVNCEVNI-DDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNV 656
           +D    Y+C CP G  G++C   + DDC    C  G    G N   C C  GF G LC  
Sbjct: 445 VDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLGANTTLCQCPLGFFGLLCEF 501

Query: 657 EI---------------------------------------NECASSPCGEGGSCVDGEN 677
           EI                                       + C S PC  GGSC   ++
Sbjct: 502 EITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDD 561

Query: 678 GFRCLCPPGSLPPLCLPPS-HPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLAR 735
            + C CP G     C     H C+  PC +G  C +A G + C C   ++G  C      
Sbjct: 562 SYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKP- 620

Query: 736 DACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL-SPCTPNPCEHGGRCESAPGQLP 794
           D+C S PC  GGTC      + C CPPG  GR CE+  SPC  +PC +GG CE       
Sbjct: 621 DSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDF- 679

Query: 795 VCSCPQGWQGPRCQQDVDECAGP------------------------------AP----- 819
            C C  G+ G RCQ +VD C  P                              AP     
Sbjct: 680 FCHCQAGYMGRRCQAEVD-CGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRV 738

Query: 820 CGPHGI-----------------------CTNLAGSFSCTCHGGYTGPSCDQDINDCDPN 856
           C PHG+                       C +    + C C  GY G  C+ + ++C  +
Sbjct: 739 CQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAH 798

Query: 857 PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPG 915
           PC NGGSC++  G++ C C  GF G  C  +VD C S+PC  G  C     ++ C CP  
Sbjct: 799 PCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPES 858

Query: 916 YGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
           + G+HCE     C  S C   G C+    S SC C+ GYTG  C  E  P
Sbjct: 859 FFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFP 908



 Score =  384 bits (985), Expect = e-106
 Identities = 220/651 (33%), Positives = 290/651 (44%), Gaps = 91/651 (13%)

Query: 741  QPCRAGGTCSSDGM----GFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPV 795
            +PC  GG C  D +     + C+C  G  GR+C L ++ C   PC++GG C         
Sbjct: 276  RPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFR- 334

Query: 796  CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP 855
            C CP G+ GP C+     C     C   G C    GS  C C  GYTG +C+ D++DC P
Sbjct: 335  CQCPAGFGGPTCETAQSPC-DTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSP 393

Query: 856  NPCLNGGSCQDGVGSFSCSCLPGFAGPRCARD----VDECLSNPC-GPGTCTDHVASFTC 910
            +PCLNGGSC D VG+++C C   F G RC        D CLS PC   GTC D    + C
Sbjct: 394  DPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVC 453

Query: 911  TCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE--ADPC-L 967
             CP G+ G  C + +PD     C NGG C+ G N+  C C  G+ G  C+ E  A PC +
Sbjct: 454  ECPEGFMGLDCRERVPD--DCECRNGGRCL-GANTTLCQCPLGFFGLLCEFEITAMPCNM 510

Query: 968  SRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC-VQTGAY-CLCP 1025
            +  C  GG C      + C C          +L   C   PC NGG C     +Y C CP
Sbjct: 511  NTQCPDGGYCMEHGGSYLCVCHTDHNASH--SLPSPCDSDPCFNGGSCDAHDDSYTCECP 568

Query: 1026 PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE-QE 1084
             G+ G+ C+      R      G      C+ GG C +    ++C CP   TG HCE  +
Sbjct: 569  RGFHGKHCE----KARPHLCSSGP-----CRNGGTCKEAGGEYHCSCPYRFTGRHCEIGK 619

Query: 1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARY 1144
             D C + PC +GGTC  Y+G Y C+C PG++G +CE     C   PC +GG+C D    +
Sbjct: 620  PDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDF 679

Query: 1145 LCSCPPGTLGVLCEINED-------------------------DCGPGPPLDSGPR---- 1175
             C C  G +G  C+   D                          C  G  L +  R    
Sbjct: 680  FCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVC 739

Query: 1176 ----------------------CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGA 1213
                                  CLH G+C D V G+ C C  GY G  CE + +ECR+  
Sbjct: 740  QPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHP 799

Query: 1214 CHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTF 1273
            C   +   C   P G + C C AGF G  C+T +  C+S PCQHGG+C       GG  +
Sbjct: 800  CR--NGGSCRNLP-GAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCE-----SGGGAY 851

Query: 1274 TCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324
             C C + F+G  CE V+  C    C     C  +     C C  G +G  C
Sbjct: 852  LCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902



 Score =  369 bits (947), Expect = e-101
 Identities = 226/677 (33%), Positives = 291/677 (42%), Gaps = 91/677 (13%)

Query: 807  CQQDVDECAGPAPCGPHGICTN--LAG--SFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862
            C      C    PC   G C +  + G  S++C+C  G+TG  C  D+N+C   PC NGG
Sbjct: 265  CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324

Query: 863  SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHC 921
            +C  G+ SF C C  GF GP C      C +  C  G  C     S  C C  GY G  C
Sbjct: 325  TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAAC 384

Query: 922  EQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ---HEA-DPCLSRPCLHGGVC 977
            E D+ DCSP  C NGG+CVD V +++CLC   + G  C+   H   D CLS PC +GG C
Sbjct: 385  EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444

Query: 978  SAAHPGFRCTCLESFTGPQCQTLV-DWCSRQPCQNGGRCVQTGA-YCLCPPGWSGRLCD- 1034
              A  G+ C C E F G  C+  V D C    C+NGGRC+      C CP G+ G LC+ 
Sbjct: 445  VDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLGANTTLCQCPLGFFGLLCEF 501

Query: 1035 -IRSLPCR--EAAAQIGVRLEQ-------------------------LCQAGGQCVDEDS 1066
             I ++PC         G  +E                           C  GG C   D 
Sbjct: 502  EITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDD 561

Query: 1067 SHYCVCPEGRTGSHCEQ-EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE-DDVD 1124
            S+ C CP G  G HCE+     C + PC++GGTC+   G Y C C   + G +CE    D
Sbjct: 562  SYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPD 621

Query: 1125 ECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVD 1184
             CAS PC +GG+C   + +Y C CPPG  G  CEI    C   P       C++ GTC D
Sbjct: 622  SCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSP-------CVNGGTCED 674

Query: 1185 LVGGFRCTCPPGYTGLRCEADI---------------NECRSGAC--HAAHTRDCLQDPG 1227
                F C C  GY G RC+A++               N  R GA   +A      L  P 
Sbjct: 675  RDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPS 734

Query: 1228 GGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE 1287
                C  H  +S P     +  C SQPC HGG C+          + C C+  + G  CE
Sbjct: 735  RIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAG-----YLCLCSTGYEGAHCE 789

Query: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHG 1347
                 CR   C  G  C+  P    C CP G  G  C +           +C ++PC HG
Sbjct: 790  LERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCET--------EVDACDSSPCQHG 841

Query: 1348 GSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNS 1407
            G C     A  + C C + + G  CE    +      P   R  C A  G   C  +   
Sbjct: 842  GRCESGGGA--YLCVCPESFFGYHCE--TVSDPCFSSPCGGRGYCLASNGSHSCTCK--- 894

Query: 1408 PGCGWDGGDCSLSVGDP 1424
               G+ G DC+  +  P
Sbjct: 895  --VGYTGEDCAKELFPP 909



 Score =  365 bits (938), Expect = e-100
 Identities = 214/662 (32%), Positives = 291/662 (43%), Gaps = 128/662 (19%)

Query: 33  LAGPGAAAPPCLDGSPCANGGRC-----TQLPSREAACLCPPGWVGERCQLE-DPCHSGP 86
           + G G     CL   PC NGG+C     T  PS    C C  G+ G RC L+ + C S P
Sbjct: 262 VGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPS--YTCSCLSGFTGRRCHLDVNECASQP 319

Query: 87  CAGRGVCQSSVVAGTARFSCRCPRGFRGPDC-SLPDPCLSSPCAHGARCSVGPDGRFLCS 145
           C   G C      G   F C+CP GF GP C +   PC +  C HG +C V  +G  +C 
Sbjct: 320 CQNGGTC----THGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQV-ENGSAVCV 374

Query: 146 CPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP----C 201
           C  GY G +C  DVD+C   +PC +GG+C++  G++ C C   + G  CE    P    C
Sbjct: 375 CQAGYTGAACEMDVDDCS-PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDAC 433

Query: 202 APSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNV-DDCPGHRCLNGGTCVDGVNTYNC 260
             +PC NGGTC    D  Y C C  GF G +C   V DDC    C NGG C+ G NT  C
Sbjct: 434 LSAPCHNGGTC-VDADQGYVCECPEGFMGLDCRERVPDDC---ECRNGGRCL-GANTTLC 488

Query: 261 QCPPEWTGQFCTEDVDE-------------------------CQLQPNA----------- 284
           QCP  + G  C  ++                           C    NA           
Sbjct: 489 QCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSD 548

Query: 285 -CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDD-CATAVCFHGATCHDRVASFYCACPM 342
            C NGG+C      ++C C  G+ G+ C +     C++  C +G TC +    ++C+CP 
Sbjct: 549 PCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPY 608

Query: 343 GKTGLLCHL--DDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400
             TG  C +   D+C S PCH    C      G+  C CPPGF+G  C+     C    +
Sbjct: 609 RFTGRHCEIGKPDSCASGPCHNGGTC--FHYIGKYKCDCPPGFSGRHCEIAPSPCF--RS 664

Query: 401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN--------------------------- 433
           PC + G C +    F C C  GY G RC+ +V+                           
Sbjct: 665 PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC 724

Query: 434 -------------------------ECLS-GPCRNQ-----ATCLDRIGQFTCICMAGFT 462
                                    +CL    CR+Q      +C DR+  + C+C  G+ 
Sbjct: 725 DRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYE 784

Query: 463 GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKC 522
           G +CE++ DEC++ PC NGG C++    + C CP+GF G  C+ +VD C S+PC++G +C
Sbjct: 785 GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC 844

Query: 523 VDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCES 581
                 Y C C E F G  C+   D C   PC   G C+    S SC C  GYTG  C  
Sbjct: 845 ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK 904

Query: 582 QV 583
           ++
Sbjct: 905 EL 906



 Score =  257 bits (656), Expect = 1e-67
 Identities = 196/664 (29%), Positives = 249/664 (37%), Gaps = 163/664 (24%)

Query: 959  CQHEADPCLS-RPCLHGGVCS----AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGG 1013
            C H    CL+ RPCL+GG C       +P + C+CL  FTG +C   V+ C+ QPCQNGG
Sbjct: 265  CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324

Query: 1014 RCVQ--TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV 1071
             C        C CP G+ G  C+    PC              CQ GGQC  E+ S  CV
Sbjct: 325  TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKE----------CQHGGQCQVENGSAVCV 374

Query: 1072 CPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDD----VDECA 1127
            C  G TG+ CE +VD C   PC +GG+C   +G Y C C   + G  CE       D C 
Sbjct: 375  CQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACL 434

Query: 1128 SQPCQHGGSCIDLVARYLCSCPPGTLGVLC-EINEDDCGPGPPLDSGPRCLHNGTCVDLV 1186
            S PC +GG+C+D    Y+C CP G +G+ C E   DDC       +G RCL   T +   
Sbjct: 435  SAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDC----ECRNGGRCLGANTTL--- 487

Query: 1187 GGFRCTCPPGYTGLRCEADIN--------ECRSGA------------CHAAHTRD----- 1221
                C CP G+ GL CE +I         +C  G             CH  H        
Sbjct: 488  ----CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPS 543

Query: 1222 -CLQDP---GGG-------FRCLCHAGFSGPRCQTVLSP-CESQPCQHGGQCRPSPGPGG 1269
             C  DP   GG        + C C  GF G  C+      C S PC++GG C+ + G   
Sbjct: 544  PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE-- 601

Query: 1270 GLTFTCHCAQPFWGPRCE-RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFP 1328
               + C C   F G  CE     SC    C  G  C       +C CPPG SG  C   P
Sbjct: 602  ---YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAP 658

Query: 1329 GSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCP 1388
                    + C  +PC++GG+C        F C C  G+ G RC+A        E     
Sbjct: 659  --------SPCFRSPCVNGGTCEDRDTD--FFCHCQAGYMGRRCQAEVDCGPPEEVKHAT 708

Query: 1389 RAACQAKRGD---QRCDR-----------------------------ECNSPGC------ 1410
                  + G      CDR                             EC S  C      
Sbjct: 709  LRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSC 768

Query: 1411 -------------GWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCD----------PA-- 1445
                         G++G  C L   +    C A  C    N   C           PA  
Sbjct: 769  QDRVAGYLCLCSTGYEGAHCELERDE----CRAHPCR---NGGSCRNLPGAYVCRCPAGF 821

Query: 1446 ----CSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCD---QGCNTEECGWDGL 1498
                C +     D+  C  GGR  +    Y   C + F    C+     C +  CG  G 
Sbjct: 822  VGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGY 881

Query: 1499 DCAS 1502
              AS
Sbjct: 882  CLAS 885



 Score =  117 bits (294), Expect = 1e-25
 Identities = 67/173 (38%), Positives = 81/173 (46%), Gaps = 14/173 (8%)

Query: 35  GPGAAAPPCLD-----GSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCA 88
           G  +  P CL+       PC +GG C    +    CLC  G+ G  C+LE D C + PC 
Sbjct: 743 GVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYL-CLCSTGYEGAHCELERDECRAHPCR 801

Query: 89  GRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCP 147
             G C++   A    + CRCP GF G  C    D C SSPC HG RC  G  G +LC CP
Sbjct: 802 NGGSCRNLPGA----YVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESG-GGAYLCVCP 856

Query: 148 PGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200
             + G  C +  D C    PC   G CL + GS  C C  GYTG  C     P
Sbjct: 857 ESFFGYHCETVSDPC-FSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFP 908



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 26/63 (41%), Positives = 33/63 (52%), Gaps = 13/63 (20%)

Query: 927  DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL------------HG 974
            +CS + C NGGTCV G ++ SC C PG+ G  C+  A   +SRPC              G
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE-LACIKVSRPCTRLFSETKAFPVWEG 1368

Query: 975  GVC 977
            GVC
Sbjct: 1369 GVC 1371



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 58/206 (28%), Positives = 78/206 (37%), Gaps = 35/206 (16%)

Query: 1333 GASNASCAAA-PCLHGGSCRPAPLA--PFFRCACAQGWTGPRCEA---PAAAPEVSEEPR 1386
            G + + C A  PCL+GG C    +   P + C+C  G+TG RC       A+        
Sbjct: 266  GHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGT 325

Query: 1387 CP------RAACQAKRGDQRCD---RECNSPGCGWDGGDCSLSVGDPWRQCEA----LQC 1433
            C       R  C A  G   C+     C++  C   GG C +  G     C+A      C
Sbjct: 326  CTHGINSFRCQCPAGFGGPTCETAQSPCDTKEC-QHGGQCQVENGSAVCVCQAGYTGAAC 384

Query: 1434 WRLFNNSRCDPACSSPAC--LYDNFDC-----HAGGRERTCNPVYEKYC--ADHFADGRC 1484
                ++   DP  +  +C  L  N+ C       G R  T +      C  A     G C
Sbjct: 385  EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444

Query: 1485 ---DQG--CNTEECGWDGLDCASEVP 1505
               DQG  C   E G+ GLDC   VP
Sbjct: 445  VDADQGYVCECPE-GFMGLDCRERVP 469



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 21/45 (46%), Positives = 26/45 (57%), Gaps = 1/45 (2%)

Query: 852  DCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC 896
            +C  NPC NGG+C  G  + SC C PGF G RC     + +S PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/70 (35%), Positives = 29/70 (41%), Gaps = 9/70 (12%)

Query: 738  CESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCS 797
            C   PC+ GGTC        C C PG +GR+CEL       PC    R  S     PV  
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCT---RLFSETKAFPV-- 1365

Query: 798  CPQGWQGPRC 807
                W+G  C
Sbjct: 1366 ----WEGGVC 1371



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 17/35 (48%), Positives = 24/35 (68%), Gaps = 1/35 (2%)

Query: 201  CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV 235
            C+ +PC+NGGTC    D  + C C PGF+G+ CE+
Sbjct: 1311 CSENPCQNGGTCVPGAD-AHSCDCGPGFKGRRCEL 1344



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 2/45 (4%)

Query: 548  DCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQVDECRSQPC 591
            +CS +PC +G  CV G  + SC C PG+ G RCE    +  S+PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 18/44 (40%), Positives = 22/44 (50%), Gaps = 1/44 (2%)

Query: 473  CQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC 516
            C  +PC NGG C    +  SC C  GF G  C+L   +  S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 14/33 (42%), Positives = 19/33 (57%)

Query: 511  CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCD 543
            C+  PC+NG  CV   D + C C  GF+G  C+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 22/44 (50%), Positives = 25/44 (56%), Gaps = 8/44 (18%)

Query: 1004 CSRQPCQNGGRCVQTGA---YCLCPPGWSGRLCDIR----SLPC 1040
            CS  PCQNGG CV  GA    C C PG+ GR C++     S PC
Sbjct: 1311 CSENPCQNGGTCVP-GADAHSCDCGPGFKGRRCELACIKVSRPC 1353



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 15/33 (45%), Positives = 19/33 (57%)

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
            C   PCQ+GGTC      + C+C PG+ G  CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 16/49 (32%), Positives = 25/49 (51%)

Query: 1111 LPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
            LP +   +  +    C+  PCQ+GG+C+     + C C PG  G  CE+
Sbjct: 1296 LPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 3/51 (5%)

Query: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPC 168
            ++P  C  +PC +G  C  G D    C C PG++GR C  ++   +V  PC
Sbjct: 1306 NVPGNCSENPCQNGGTCVPGADAHS-CDCGPGFKGRRC--ELACIKVSRPC 1353



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 14/33 (42%), Positives = 21/33 (63%)

Query: 239  DCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
            +C  + C NGGTCV G + ++C C P + G+ C
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRC 1342



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 20/51 (39%), Positives = 24/51 (47%), Gaps = 9/51 (17%)

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE----RVARSCREL 1296
            C   PCQ+GG C P     G    +C C   F G RCE    +V+R C  L
Sbjct: 1311 CSENPCQNGGTCVP-----GADAHSCDCGPGFKGRRCELACIKVSRPCTRL 1356



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 12/62 (19%)

Query: 623  DCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVE-----------INECASSPCGEGG 670
            +C+ NPC   G C  G + + C C PGF G  C +             +E  + P  EGG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369

Query: 671  SC 672
             C
Sbjct: 1370 VC 1371



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 1/45 (2%)

Query: 586  CRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCT 630
            C   PC++GG C+   D + C C  G  G  CE+      S PCT
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPCT 1354



 Score = 37.7 bits (86), Expect = 0.13
 Identities = 19/42 (45%), Positives = 25/42 (59%), Gaps = 3/42 (7%)

Query: 47   SPCANGGRCTQLPSREA-ACLCPPGWVGERCQLEDPCHSGPC 87
            +PC NGG C  +P  +A +C C PG+ G RC+L     S PC
Sbjct: 1314 NPCQNGGTC--VPGADAHSCDCGPGFKGRRCELACIKVSRPC 1353



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 19/61 (31%), Positives = 25/61 (40%), Gaps = 11/61 (18%)

Query: 435  CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVD-----------IDECQSSPCVNGGV 483
            C   PC+N  TC+      +C C  GF G  CE+              E ++ P   GGV
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370

Query: 484  C 484
            C
Sbjct: 1371 C 1371



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 4/43 (9%)

Query: 661  CASSPCGEGGSCVDGENGFRCLCPPG----SLPPLCLPPSHPC 699
            C+ +PC  GG+CV G +   C C PG         C+  S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPC 1353



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)

Query: 400  NPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPC 440
            NPC++ G CV    +  C CG G+ G RCE    + +S PC
Sbjct: 1314 NPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 25/94 (26%), Positives = 34/94 (36%), Gaps = 16/94 (17%)

Query: 283  NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPM 342
            N C NGGTC      HSC C  G+ G  C           C   +    R+ S   A P+
Sbjct: 1314 NPCQNGGTCVPGADAHSCDCGPGFKGRRCE--------LACIKVSRPCTRLFSETKAFPV 1365

Query: 343  GKTGLLCHL--------DDACVSNPCHEDAICDT 368
             + G+  H+         D C    C   ++  T
Sbjct: 1366 WEGGVCHHVYKRVYRVHQDICFKESCESTSLKKT 1399



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 19/48 (39%), Positives = 21/48 (43%)

Query: 1156 LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
            L E    D G  P   S   C + GTCV       C C PG+ G RCE
Sbjct: 1296 LPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 6/45 (13%)

Query: 1329 GSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
            G+ PG    +C+  PC +GG+C P   A    C C  G+ G RCE
Sbjct: 1305 GNVPG----NCSENPCQNGGTCVPG--ADAHSCDCGPGFKGRRCE 1343



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 18/47 (38%), Positives = 20/47 (42%), Gaps = 4/47 (8%)

Query: 82   CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPC 128
            C   PC   G C    V G    SC C  GF+G  C L    +S PC
Sbjct: 1311 CSENPCQNGGTC----VPGADAHSCDCGPGFKGRRCELACIKVSRPC 1353



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 15/35 (42%), Positives = 21/35 (60%), Gaps = 3/35 (8%)

Query: 775  CTPNPCEHGGRCESAPG-QLPVCSCPQGWQGPRCQ 808
            C+ NPC++GG C   PG     C C  G++G RC+
Sbjct: 1311 CSENPCQNGGTC--VPGADAHSCDCGPGFKGRRCE 1343



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 18/57 (31%), Positives = 24/57 (42%), Gaps = 11/57 (19%)

Query: 167  PCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAV----PCA-------PSPCRNGGTC 212
            PC++GGTC+    +  C C  G+ G  CE   +    PC          P   GG C
Sbjct: 1315 PCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVC 1371



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 21/68 (30%), Positives = 27/68 (39%), Gaps = 7/68 (10%)

Query: 966  CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCP 1025
            C   PC +GG C        C C   F G +C+      SR PC       +T A+    
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSR-PCTR--LFSETKAF---- 1363

Query: 1026 PGWSGRLC 1033
            P W G +C
Sbjct: 1364 PVWEGGVC 1371



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 14/33 (42%), Positives = 17/33 (51%), Gaps = 1/33 (3%)

Query: 891  CLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCE 922
            C  NPC   GTC     + +C C PG+ G  CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 21/59 (35%), Positives = 23/59 (38%), Gaps = 11/59 (18%)

Query: 1052 EQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE----QEVDPCL-------AQPCQHGGTC 1099
            E  CQ GG CV    +H C C  G  G  CE    +   PC        A P   GG C
Sbjct: 1313 ENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVC 1371



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 4/46 (8%)

Query: 699  CAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPC 743
            C+  PC +G  C        C C PG+ G RC  +  +    S+PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK---VSRPC 1353


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  351 bits (900), Expect = 5e-96
 Identities = 170/456 (37%), Positives = 236/456 (51%), Gaps = 39/456 (8%)

Query: 311 CSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGL---LCHLDDACVSNPCHEDAICD 367
           C++N   C +  C + +TC D      C+C      L     ++ D C SNPC   A C 
Sbjct: 27  CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86

Query: 368 TNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPR 427
             P     +C CPPG++G  C+  +  C  G N C+H G C       +C C  GY G  
Sbjct: 87  NTPGERSFLCKCPPGYSGTICETTIGSC--GKNSCQHGGICHQDPIYPVCICPAGYAGRF 144

Query: 428 CETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR 487
           CE D +EC S PC+N A C D I  ++C C+ G+ G +C++++DEC S PC N   C + 
Sbjct: 145 CEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNE 204

Query: 488 VNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVD 547
           +  ++C CP  +SG  C+L++DEC S PC NGA C D    Y C CA GF G  C+ N D
Sbjct: 205 IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTD 264

Query: 548 DCSPDPC-HHGRCVDGIASFSCAC-APGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
           +C+  PC H G CVDG   +SC C   G+TGT CE+ +  C S+PC +   C D VD Y 
Sbjct: 265 ECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYT 324

Query: 606 CRCPSGTTGVNCEVNIDDCASNPC-TFGVCRD--------------------GINRYDCV 644
           C C  G TG  CE+++++C SNPC + G C +                      + Y C+
Sbjct: 325 CHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCI 384

Query: 645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPL------CLPPSHP 698
           CQPGFTG  C  ++NEC+S+PC  GG+C +    + C CP  +L         C      
Sbjct: 385 CQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLG 444

Query: 699 CAHEPC-SHGIC----YDAPGGFRCVCEPGWSGPRC 729
           C H+ C ++G C     D   GF C+C  G++G  C
Sbjct: 445 CTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC 480



 Score =  329 bits (843), Expect = 2e-89
 Identities = 172/459 (37%), Positives = 228/459 (49%), Gaps = 44/459 (9%)

Query: 82  CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC-SLPDPCLSSPCAHGARCSVGPDG 140
           C S  C     C+          SC         DC ++ DPC S+PC   A C   P  
Sbjct: 34  CLSNSCQNNSTCKDFSKDNDC--SCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGE 91

Query: 141 R-FLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAV 199
           R FLC CPPGY G  C + +  C     C+HGG C   P    C CPAGY G  CE    
Sbjct: 92  RSFLCKCPPGYSGTICETTIGSCGKNS-CQHGGICHQDPIYPVCICPAGYAGRFCEIDHD 150

Query: 200 PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYN 259
            CA SPC+NG  C Q G   Y C C+PG++G++C++ VD+C    C N  TC++ +  Y 
Sbjct: 151 ECASSPCQNGAVC-QDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYT 209

Query: 260 CQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCA 319
           C CP  ++G  C  ++DEC  QP  C NG TC + LG + C C  G+ G+ C  N D+CA
Sbjct: 210 CICPHNYSGVNCELEIDECWSQP--CLNGATCQDALGAYFCDCAPGFLGDHCELNTDECA 267

Query: 320 TAVCFHGATCHDRVASFYCACP-MGKTGLLCH-LDDACVSNPCHEDAICDTNPVNGRAIC 377
           +  C HG  C D    + C C   G TG  C  L   C S PCH +A C+ +  N    C
Sbjct: 268 SQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDN--YTC 325

Query: 378 TCPPGFTGGACDQDVDECSIGANPCEHLGRCV--------------------NTQGSFLC 417
            C PG+TG  C+ D++EC+  +NPC+  G CV                    +    ++C
Sbjct: 326 HCWPGYTGAQCEIDLNECN--SNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVC 383

Query: 418 QCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCIC------MAGFTGTYCEVDID 471
            C  G+TG  CE DVNEC S PC+N  TC +  G +TC C         + G  C   + 
Sbjct: 384 ICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILL 443

Query: 472 ECQSSPCVNGGVC----KDRVNGFSCTCPSGFSGSTCQL 506
            C    C+N G C    +D  +GFSC CPSG++GS C++
Sbjct: 444 GCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  320 bits (820), Expect = 1e-86
 Identities = 162/462 (35%), Positives = 227/462 (49%), Gaps = 43/462 (9%)

Query: 155 CRSDVDECRVGEPCRHGGTCLNTPGSFRCQCP--AGYTGPLCENPAVPCAPSPCRNGGTC 212
           C  +   C +   C++  TC +      C C   A      C+N   PC  +PC+   TC
Sbjct: 27  CNKNNTRC-LSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATC 85

Query: 213 RQS-GDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
             + G+ ++ C C PG+ G  CE  +  C  + C +GG C        C CP  + G+FC
Sbjct: 86  VNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFC 145

Query: 272 TEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHD 331
             D DEC   P  C NG  C + + G+SC CV G+ G  C   +D+CA+  C + ATC +
Sbjct: 146 EIDHDECASSP--CQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLN 203

Query: 332 RVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390
            +  + C CP   +G+ C L+ D C S PC   A C      G   C C PGF G  C+ 
Sbjct: 204 EIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQD--ALGAYFCDCAPGFLGDHCEL 261

Query: 391 DVDECSIGANPCEHLGRCVNTQGSFLCQC-GRGYTGPRCETDVNECLSGPCRNQATCLDR 449
           + DEC+  + PC H G CV+ +  + C C G G+TG  CET +  C S PC N ATC D 
Sbjct: 262 NTDECA--SQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDS 319

Query: 450 IGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKD--------------------RVN 489
           +  +TC C  G+TG  CE+D++EC S+PC + G C +                      +
Sbjct: 320 VDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEAS 379

Query: 490 GFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEG------FEGTLCD 543
           G+ C C  GF+G  C+ DV+EC+S PC+NG  C + P  Y C C         + G  C 
Sbjct: 380 GYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCS 439

Query: 544 RNVDDCSPDPC-HHGRCV----DGIASFSCACAPGYTGTRCE 580
             +  C+   C ++G C+    DG   FSC C  GYTG+ CE
Sbjct: 440 DILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481



 Score =  299 bits (766), Expect = 2e-80
 Identities = 158/462 (34%), Positives = 213/462 (46%), Gaps = 81/462 (17%)

Query: 233 CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG--QFCTEDVDECQLQPNACHNGGT 290
           C  N   C  + C N  TC D     +C C        + C    D C   P  C    T
Sbjct: 27  CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNP--CQGSAT 84

Query: 291 CFNTLGGHS--CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLL 348
           C NT G  S  C C  G++G  C   I  C    C HG  CH       C CP G  G  
Sbjct: 85  CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144

Query: 349 CHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGR 407
           C +D D C S+PC   A+C    ++G + C C PG+ G  CD +VDEC+  ++PC++   
Sbjct: 145 CEIDHDECASSPCQNGAVCQDG-IDGYS-CFCVPGYQGRHCDLEVDECA--SDPCKNEAT 200

Query: 408 CVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCE 467
           C+N  G + C C   Y+G  CE +++EC S PC N ATC D +G + C C  GF G +CE
Sbjct: 201 CLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260

Query: 468 VDIDECQSSPCVNGGVCKDRVNGFSCTCP-SGFSGSTCQLDVDECASTPCRNGAKCVDQP 526
           ++ DEC S PC++GG+C D  N +SC C  SGF+G+ C+  +  C S PC N A C D  
Sbjct: 261 LNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSV 320

Query: 527 DGYECRCAEGFEGTLCDRNVDDCSPDPCH-HGRCVD-----------GIAS--------- 565
           D Y C C  G+ G  C+ ++++C+ +PC  +G CV+           G+ S         
Sbjct: 321 DNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASG 380

Query: 566 FSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCP---------------- 609
           + C C PG+TG  CE  V+EC S PC++GG C +L   Y C CP                
Sbjct: 381 YVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSD 440

Query: 610 --------------------------------SGTTGVNCEV 619
                                           SG TG  CE+
Sbjct: 441 ILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  298 bits (762), Expect = 5e-80
 Identities = 158/486 (32%), Positives = 224/486 (46%), Gaps = 45/486 (9%)

Query: 617  CEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTG--PLCNVEINECASSPCGEGGSCV 673
            C  N   C SN C     C+D     DC C          C+   + C S+PC    +CV
Sbjct: 27   CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86

Query: 674  D--GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCS 730
            +  GE  F C CPPG    +C      C    C HG IC+  P    C+C  G++G  C 
Sbjct: 87   NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146

Query: 731  QSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESA 789
              +  D C S PC+ G  C     G+ C C PG QGR C+L +  C  +PC++   C + 
Sbjct: 147  --IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNE 204

Query: 790  PGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQD 849
             G+   C CP  + G  C+ ++DEC    PC     C +  G++ C C  G+ G  C+ +
Sbjct: 205  IGRY-TCICPHNYSGVNCELEIDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCELN 262

Query: 850  INDCDPNPCLNGGSCQDGVGSFSCSCL-PGFAGPRCARDVDECLSNPC-GPGTCTDHVAS 907
             ++C   PCL+GG C DG   +SC+C   GF G  C   +  C S PC    TC D V +
Sbjct: 263  TDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDN 322

Query: 908  FTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVD--------------------GVNSFS 947
            +TC C PGY G  CE DL +C+ + C + G CV+                      + + 
Sbjct: 323  YTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYV 382

Query: 948  CLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTC------LESFTGPQCQTLV 1001
            C+C+PG+TG HC+ + + C S PC +GG C      + C C         + G  C  ++
Sbjct: 383  CICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDIL 442

Query: 1002 DWCSRQPCQNGGRCV------QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLC 1055
              C+ Q C N G C+      Q G  CLCP G++G LC+I +    E    + V+   + 
Sbjct: 443  LGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVT 502

Query: 1056 QAGGQC 1061
              G  C
Sbjct: 503  TKGSVC 508



 Score =  284 bits (727), Expect = 6e-76
 Identities = 158/477 (33%), Positives = 206/477 (43%), Gaps = 46/477 (9%)

Query: 921  CEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAH--CQHEADPCLSRPCLHGGVC- 977
            C ++   C  +SC N  TC D      C C          C +  DPC S PC     C 
Sbjct: 27   CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86

Query: 978  -SAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--CLCPPGWSGRLCD 1034
             +     F C C   ++G  C+T +  C +  CQ+GG C Q   Y  C+CP G++GR C+
Sbjct: 87   NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146

Query: 1035 IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQ 1094
            I    C  +           CQ G  C D    + C C  G  G HC+ EVD C + PC+
Sbjct: 147  IDHDECASSP----------CQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCK 196

Query: 1095 HGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLG 1154
            +  TC   +G Y C C   Y+G NCE ++DEC SQPC +G +C D +  Y C C PG LG
Sbjct: 197  NEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLG 256

Query: 1155 VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCP-PGYTGLRCEADINECRSGA 1213
              CE+N D+C   P       CLH G CVD    + C C   G+TG  CE  +  C S  
Sbjct: 257  DHCELNTDECASQP-------CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKP 309

Query: 1214 CHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC--RPSPGPGGGL 1271
            CH   T    +D    + C C  G++G +C+  L+ C S PCQ  G+C    S    G +
Sbjct: 310  CHNNAT---CEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRI 366

Query: 1272 T-------------FTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPG 1318
            T             + C C   F G  CE     C    C  G  C+  P    C CP  
Sbjct: 367  TGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCP-- 424

Query: 1319 LSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRP--APLAPFFRCACAQGWTGPRCE 1373
                S   + G         C    CL+ G+C P        F C C  G+TG  CE
Sbjct: 425  FDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481



 Score =  283 bits (723), Expect = 2e-75
 Identities = 151/462 (32%), Positives = 208/462 (45%), Gaps = 83/462 (17%)

Query: 464 TYCEVDIDECQSSPCVNGGVCKD------------------------------------- 486
           ++C  +   C S+ C N   CKD                                     
Sbjct: 25  SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84

Query: 487 -----RVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTL 541
                    F C CP G+SG+ C+  +  C    C++G  C   P    C C  G+ G  
Sbjct: 85  CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144

Query: 542 CDRNVDDCSPDPCHHGR-CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
           C+ + D+C+  PC +G  C DGI  +SC C PGY G  C+ +VDEC S PC++   CL+ 
Sbjct: 145 CEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNE 204

Query: 601 VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEIN 659
           + +Y C CP   +GVNCE+ ID+C S PC  G  C+D +  Y C C PGF G  C +  +
Sbjct: 205 IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTD 264

Query: 660 ECASSPCGEGGSCVDGENGFRCLCP-PGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFR 717
           ECAS PC  GG CVDGEN + C C   G     C      C  +PC ++  C D+   + 
Sbjct: 265 ECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYT 324

Query: 718 CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSS--------------------DGMGFH 757
           C C PG++G +C   L  + C S PC++ G C                      +  G+ 
Sbjct: 325 CHCWPGYTGAQCEIDL--NECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYV 382

Query: 758 CTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCP-----QGWQGPRCQQDV 811
           C C PG  G  CE  ++ C+ NPC++GG CE+ PG    C CP     + + G R   D+
Sbjct: 383 CICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNY-TCHCPFDNLSRTFYGGRDCSDI 441

Query: 812 ------DECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD 847
                  +C     C PH    +    FSC C  GYTG  C+
Sbjct: 442 LLGCTHQQCLNNGTCIPH--FQDGQHGFSCLCPSGYTGSLCE 481



 Score =  261 bits (666), Expect = 7e-69
 Identities = 149/462 (32%), Positives = 194/462 (41%), Gaps = 90/462 (19%)

Query: 775  CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPA---PCGPHGICTNLAG 831
            C  N C++   C+        CSC          +D D    P    PC     C N  G
Sbjct: 34   CLSNSCQNNSTCKDFSKDND-CSCSD--TANNLDKDCDNMKDPCFSNPCQGSATCVNTPG 90

Query: 832  --SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVD 889
              SF C C  GY+G  C+  I  C  N C +GG C        C C  G+AG  C  D D
Sbjct: 91   ERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHD 150

Query: 890  ECLSNPCGPGT-CTDHVASFTCTCPPGYGGFH---------------------------- 920
            EC S+PC  G  C D +  ++C C PGY G H                            
Sbjct: 151  ECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTC 210

Query: 921  ----------CEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRP 970
                      CE ++ +C    C NG TC D + ++ C C PG+ G HC+   D C S+P
Sbjct: 211  ICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQP 270

Query: 971  CLHGGVCSAAHPGFRCTCLES-FTGPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLCPPG 1027
            CLHGG+C      + C C  S FTG  C+TL+  C  +PC N   C  +     C C PG
Sbjct: 271  CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPG 330

Query: 1028 WSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD--------------------EDSS 1067
            ++G  C+I    C              CQ+ G+CV+                    E S 
Sbjct: 331  YTGAQCEIDLNECN----------SNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASG 380

Query: 1068 HYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCEC------LPGYNGDNCED 1121
            + C+C  G TG HCE++V+ C + PCQ+GGTC    G Y C C         Y G +C D
Sbjct: 381  YVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSD 440

Query: 1122 DVDECASQPCQHGGSCI----DLVARYLCSCPPGTLGVLCEI 1159
             +  C  Q C + G+CI    D    + C CP G  G LCEI
Sbjct: 441  ILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  249 bits (635), Expect = 3e-65
 Identities = 154/462 (33%), Positives = 203/462 (43%), Gaps = 89/462 (19%)

Query: 43  CLDGSPCANGGRCTQLPSREAACLCPP--GWVGERCQ-LEDPCHSGPCAGRGVCQSSVVA 99
           CL  S C N   C    S++  C C      + + C  ++DPC S PC G   C ++   
Sbjct: 34  CLSNS-CQNNSTCKDF-SKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNT--P 89

Query: 100 GTARFSCRCPRGFRG---------------------------PDCSLP------------ 120
           G   F C+CP G+ G                           P C  P            
Sbjct: 90  GERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDH 149

Query: 121 DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180
           D C SSPC +GA C  G DG + C C PGYQGR C  +VDEC   +PC++  TCLN  G 
Sbjct: 150 DECASSPCQNGAVCQDGIDG-YSCFCVPGYQGRHCDLEVDEC-ASDPCKNEATCLNEIGR 207

Query: 181 FRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC 240
           + C CP  Y+G  CE     C   PC NG TC Q     Y C C PGF G +CE+N D+C
Sbjct: 208 YTCICPHNYSGVNCELEIDECWSQPCLNGATC-QDALGAYFCDCAPGFLGDHCELNTDEC 266

Query: 241 PGHRCLNGGTCVDGVNTYNCQCPPE-WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
               CL+GG CVDG N Y+C C    +TG  C   +  C  +P  CHN  TC +++  ++
Sbjct: 267 ASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKP--CHNNATCEDSVDNYT 324

Query: 300 CVCVNGWTGESCSQNIDDCATAVCFHGATC--------------------HDRVASFYCA 339
           C C  G+TG  C  ++++C +  C     C                    +   + + C 
Sbjct: 325 CHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCI 384

Query: 340 CPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCP-----PGFTGGACDQDVD 393
           C  G TG+ C  D + C SNPC     C+  P  G   C CP       F GG   +D  
Sbjct: 385 CQPGFTGIHCEEDVNECSSNPCQNGGTCENLP--GNYTCHCPFDNLSRTFYGG---RDCS 439

Query: 394 ECSIGA--NPCEHLGRCV----NTQGSFLCQCGRGYTGPRCE 429
           +  +G     C + G C+    + Q  F C C  GYTG  CE
Sbjct: 440 DILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481



 Score =  179 bits (454), Expect = 3e-44
 Identities = 77/195 (39%), Positives = 109/195 (55%), Gaps = 9/195 (4%)

Query: 850  INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFT 909
            +N C+ NPCL+GG+C+D   S+ CSC  G++G  C  ++DEC SNPC  G C+D VA++ 
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYH 1199

Query: 910  CTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC--- 966
            CTC PGY G +CE D+ +C    C NG TC+   N +SCLC   +TG  C+    P    
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVC 1259

Query: 967  ----LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGA 1020
                 +  C +GG C+      +C C   FTG  C+  +D C+  PC NGG C  +    
Sbjct: 1260 GNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKF 1319

Query: 1021 YCLCPPGWSGRLCDI 1035
             CLC   ++G  C++
Sbjct: 1320 QCLCDVAFAGERCEV 1334



 Score =  176 bits (447), Expect = 2e-43
 Identities = 77/200 (38%), Positives = 112/200 (56%), Gaps = 9/200 (4%)

Query: 432  VNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGF 491
            +N C S PC +   C D    + C C  G++G +CE++IDEC S+PC++G  C DRV  +
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAY 1198

Query: 492  SCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNV----- 546
             CTC  G++G  C++D+D C S  C NGA C+   +GY C C   F G  C ++      
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258

Query: 547  --DDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603
              ++ +   C++G  C +      C C PG+TG  CE  +DEC S PC +GG C DL++K
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318

Query: 604  YLCRCPSGTTGVNCEVNIDD 623
            + C C     G  CEV++ D
Sbjct: 1319 FQCLCDVAFAGERCEVDLAD 1338



 Score =  167 bits (423), Expect = 1e-40
 Identities = 129/474 (27%), Positives = 166/474 (35%), Gaps = 93/474 (19%)

Query: 1079 SHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNG--DNCEDDVDECASQPCQHGGS 1136
            S C +    CL+  CQ+  TC+ +     C C    N    +C++  D C S PCQ   +
Sbjct: 25   SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84

Query: 1137 CIDLVAR--YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCP 1194
            C++      +LC CPPG  G +CE     CG          C H G C        C CP
Sbjct: 85   CVNTPGERSFLCKCPPGYSGTICETTIGSCGKN-------SCQHGGICHQDPIYPVCICP 137

Query: 1195 PGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQP 1254
             GY G  CE D +EC S  C         QD   G+ C C  G+ G  C   +  C S P
Sbjct: 138  AGYAGRFCEIDHDECASSPCQNGAV---CQDGIDGYSCFCVPGYQGRHCDLEVDECASDP 194

Query: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCA 1314
            C++   C    G      +TC C   + G  CE     C    C  G  CQ       C 
Sbjct: 195  CKNEATCLNEIG-----RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCD 249

Query: 1315 CPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCAC-AQGWTGPRCE 1373
            C PG  G  C          +   CA+ PCLHGG C        + C C   G+TG  CE
Sbjct: 250  CAPGFLGDHCE--------LNTDECASQPCLHGGLCVDGENR--YSCNCTGSGFTGTHCE 299

Query: 1374 APAAAPEVSEEPRCPRAACQAKRGDQRCD--------------RECNSPGCGWDGGDCSL 1419
                 P    +P    A C+    +  C                ECNS  C  +G    L
Sbjct: 300  --TLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVEL 357

Query: 1420 SVGDPWRQCEALQ--------------CWRLFNNSRCDP---ACSSPAC--------LYD 1454
            S    + +   L               C   F    C+     CSS  C        L  
Sbjct: 358  SSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPG 417

Query: 1455 NFDCHA----------GGRERTCNPVY----------EKYCADHFADGRCDQGC 1488
            N+ CH           GGR+  C+ +              C  HF DG+    C
Sbjct: 418  NYTCHCPFDNLSRTFYGGRD--CSDILLGCTHQQCLNNGTCIPHFQDGQHGFSC 469



 Score =  166 bits (420), Expect = 2e-40
 Identities = 76/198 (38%), Positives = 102/198 (51%), Gaps = 10/198 (5%)

Query: 582  QVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRY 641
            Q++ C S PC HGG C D+   Y C CP G +G +CE+NID+C SNPC  G C D +  Y
Sbjct: 1139 QLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAY 1198

Query: 642  DCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP---PSHP 698
             C C+PG+TG  C V+I+ C S  C  G +C+   NG+ CLC        C     PS  
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258

Query: 699  CAHEPC-----SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDG 753
            C +E       + G C +     +C+C PG++G  C + +  D C S PC  GG C    
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI--DECASDPCVNGGLCQDLL 1316

Query: 754  MGFHCTCPPGVQGRQCEL 771
              F C C     G +CE+
Sbjct: 1317 NKFQCLCDVAFAGERCEV 1334



 Score =  165 bits (417), Expect = 5e-40
 Identities = 79/211 (37%), Positives = 106/211 (50%), Gaps = 16/211 (7%)

Query: 769  CELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTN 828
            C  L+ C  NPC HGG CE        CSCP GW G  C+ ++DEC    PC  HG C++
Sbjct: 1137 CLQLNVCNSNPCLHGGNCEDIYSSYH-CSCPLGWSGKHCELNIDECFS-NPC-IHGNCSD 1193

Query: 829  LAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDV 888
               ++ CTC  GYTG +C+ DI++C  + C NG +C      +SC C   F G  C +  
Sbjct: 1194 RVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ-- 1251

Query: 889  DECLSNPCG----------PGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT 938
                S  CG           G CT+      C C PG+ G  CE+D+ +C+   C NGG 
Sbjct: 1252 SRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGL 1311

Query: 939  CVDGVNSFSCLCRPGYTGAHCQHE-ADPCLS 968
            C D +N F CLC   + G  C+ + AD  +S
Sbjct: 1312 CQDLLNKFQCLCDVAFAGERCEVDLADDLIS 1342



 Score =  162 bits (409), Expect = 5e-39
 Identities = 74/186 (39%), Positives = 97/186 (52%), Gaps = 8/186 (4%)

Query: 506  LDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIAS 565
            L ++ C S PC +G  C D    Y C C  G+ G  C+ N+D+C  +PC HG C D +A+
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAA 1197

Query: 566  FSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVN--IDD 623
            + C C PGYTG  CE  +D C+S  C +G  C+   + Y C C    TG  C  +     
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPST 1257

Query: 624  CASNPCTFGVCRDGIN------RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGEN 677
               N  T   C +G N         C+C+PGFTG  C  +I+ECAS PC  GG C D  N
Sbjct: 1258 VCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLN 1317

Query: 678  GFRCLC 683
             F+CLC
Sbjct: 1318 KFQCLC 1323



 Score =  161 bits (407), Expect = 8e-39
 Identities = 71/200 (35%), Positives = 112/200 (56%), Gaps = 10/200 (5%)

Query: 468  VDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPD 527
            + ++ C S+PC++GG C+D  + + C+CP G+SG  C+L++DEC S PC +G  C D+  
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVA 1196

Query: 528  GYECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQ---- 582
             Y C C  G+ G  C+ ++D+C    C +G  C+     +SC C   +TG  C       
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256

Query: 583  ---VDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGI 638
                +E  +  C +GG C +   +  C C  G TG  CE +ID+CAS+PC   G+C+D +
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316

Query: 639  NRYDCVCQPGFTGPLCNVEI 658
            N++ C+C   F G  C V++
Sbjct: 1317 NKFQCLCDVAFAGERCEVDL 1336



 Score =  158 bits (400), Expect = 5e-38
 Identities = 71/191 (37%), Positives = 100/191 (52%), Gaps = 7/191 (3%)

Query: 167  PCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP 226
            PC HGG C +   S+ C CP G++G  CE     C  +PC +G    +     Y C C P
Sbjct: 1147 PCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVA--AYHCTCEP 1204

Query: 227  GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPN--- 283
            G+ G NCEV++D+C  H+C NG TC+   N Y+C C   +TG+FC +      +  N   
Sbjct: 1205 GYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKT 1264

Query: 284  --ACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACP 341
               C+NGG C        C+C  G+TGE C ++ID+CA+  C +G  C D +  F C C 
Sbjct: 1265 NLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCD 1324

Query: 342  MGKTGLLCHLD 352
            +   G  C +D
Sbjct: 1325 VAFAGERCEVD 1335



 Score =  157 bits (397), Expect = 1e-37
 Identities = 74/199 (37%), Positives = 104/199 (52%), Gaps = 13/199 (6%)

Query: 318  CATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAI 376
            C +  C HG  C D  +S++C+CP+G +G  C L+ D C SNPC      D         
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYH--- 1199

Query: 377  CTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDV---- 432
            CTC PG+TG  C+ D+D C   ++ C +   C++    + C C   +TG  C        
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQ--SHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPST 1257

Query: 433  ---NECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVN 489
               NE  +  C N   C +   +  C+C  GFTG +CE DIDEC S PCVNGG+C+D +N
Sbjct: 1258 VCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLN 1317

Query: 490  GFSCTCPSGFSGSTCQLDV 508
             F C C   F+G  C++D+
Sbjct: 1318 KFQCLCDVAFAGERCEVDL 1336



 Score =  150 bits (378), Expect = 2e-35
 Identities = 77/206 (37%), Positives = 98/206 (47%), Gaps = 10/206 (4%)

Query: 1046 QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGG 1105
            Q+ V     C  GG C D  SS++C CP G +G HCE  +D C + PC H G C   +  
Sbjct: 1139 QLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAA 1197

Query: 1106 YMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLC---EINED 1162
            Y C C PGY G NCE D+D C S  C +G +CI     Y C C     G  C    +   
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPST 1257

Query: 1163 DCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDC 1222
             CG      +   C + G C +     +C C PG+TG  CE DI+EC S  C        
Sbjct: 1258 VCGNE---KTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPC---VNGGL 1311

Query: 1223 LQDPGGGFRCLCHAGFSGPRCQTVLS 1248
             QD    F+CLC   F+G RC+  L+
Sbjct: 1312 CQDLLNKFQCLCDVAFAGERCEVDLA 1337



 Score =  148 bits (374), Expect = 5e-35
 Identities = 75/211 (35%), Positives = 96/211 (45%), Gaps = 12/211 (5%)

Query: 733  LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPG 791
            L  + C S PC  GG C      +HC+CP G  G+ CEL +  C  NPC HG   +    
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAA 1197

Query: 792  QLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI- 850
                C+C  G+ G  C+ D+D C     C     C +    +SC C G +TG  C Q   
Sbjct: 1198 YH--CTCEPGYTGVNCEVDIDNCQSHQ-CANGATCISHTNGYSCLCFGNFTGKFCRQSRL 1254

Query: 851  ------NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTD 903
                  N+     C NGG+C +      C C PGF G  C +D+DEC S+PC   G C D
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQD 1314

Query: 904  HVASFTCTCPPGYGGFHCEQDLPDCSPSSCF 934
             +  F C C   + G  CE DL D   S  F
Sbjct: 1315 LLNKFQCLCDVAFAGERCEVDLADDLISDIF 1345



 Score =  140 bits (352), Expect = 2e-32
 Identities = 70/208 (33%), Positives = 99/208 (47%), Gaps = 16/208 (7%)

Query: 76   CQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARC 134
            C   + C+S PC   G C+       + + C CP G+ G  C L  D C S+PC HG  C
Sbjct: 1137 CLQLNVCNSNPCLHGGNCEDIY----SSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NC 1191

Query: 135  SVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC 194
            S      + C+C PGY G +C  D+D C+    C +G TC++    + C C   +TG  C
Sbjct: 1192 S-DRVAAYHCTCEPGYTGVNCEVDIDNCQ-SHQCANGATCISHTNGYSCLCFGNFTGKFC 1249

Query: 195  ENPAVPCAPS-------PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLN 247
                +P            C NGG C +       C C PGF G+ CE ++D+C    C+N
Sbjct: 1250 RQSRLPSTVCGNEKTNLTCYNGGNCTEF-QTELKCMCRPGFTGEWCEKDIDECASDPCVN 1308

Query: 248  GGTCVDGVNTYNCQCPPEWTGQFCTEDV 275
            GG C D +N + C C   + G+ C  D+
Sbjct: 1309 GGLCQDLLNKFQCLCDVAFAGERCEVDL 1336



 Score =  138 bits (348), Expect = 6e-32
 Identities = 67/206 (32%), Positives = 96/206 (46%), Gaps = 18/206 (8%)

Query: 966  CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY-CLC 1024
            C S PCLHGG C   +  + C+C   ++G  C+  +D C   PC +G    +  AY C C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTC 1202

Query: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084
             PG++G  C++    C+             C  G  C+   + + C+C    TG  C Q 
Sbjct: 1203 EPGYTGVNCEVDIDNCQS----------HQCANGATCISHTNGYSCLCFGNFTGKFCRQS 1252

Query: 1085 VDPCLA-------QPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSC 1137
              P            C +GG C  +     C C PG+ G+ CE D+DECAS PC +GG C
Sbjct: 1253 RLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLC 1312

Query: 1138 IDLVARYLCSCPPGTLGVLCEINEDD 1163
             DL+ ++ C C     G  CE++  D
Sbjct: 1313 QDLLNKFQCLCDVAFAGERCEVDLAD 1338



 Score =  137 bits (346), Expect = 9e-32
 Identities = 72/205 (35%), Positives = 96/205 (46%), Gaps = 12/205 (5%)

Query: 656  VEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG 715
            +++N C S+PC  GG+C D  + + C CP G     C      C   PC HG C D    
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAA 1197

Query: 716  FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQG---RQCELL 772
            + C CEPG++G  C   +  D C+S  C  G TC S   G+ C C     G   RQ  L 
Sbjct: 1198 YHCTCEPGYTGVNCEVDI--DNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255

Query: 773  SPCTPN-----PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827
            S    N      C +GG C     +L  C C  G+ G  C++D+DECA   PC   G+C 
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELK-CMCRPGFTGEWCEKDIDECASD-PCVNGGLCQ 1313

Query: 828  NLAGSFSCTCHGGYTGPSCDQDIND 852
            +L   F C C   + G  C+ D+ D
Sbjct: 1314 DLLNKFQCLCDVAFAGERCEVDLAD 1338



 Score =  137 bits (345), Expect = 1e-31
 Identities = 71/210 (33%), Positives = 99/210 (47%), Gaps = 21/210 (10%)

Query: 1084 EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR 1143
            +++ C + PC HGG C      Y C C  G++G +CE ++DEC S PC H G+C D VA 
Sbjct: 1139 QLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAA 1197

Query: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
            Y C+C PG  GV CE++ D+C          +C +  TC+    G+ C C   +TG  C 
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNC-------QSHQCANGATCISHTNGYSCLCFGNFTGKFCR 1250

Query: 1204 ADINECRSGACHAAHTRDCLQDPGG------GFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257
               +   S  C    T     + G         +C+C  GF+G  C+  +  C S PC +
Sbjct: 1251 Q--SRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVN 1308

Query: 1258 GGQCRPSPGPGGGLTFTCHCAQPFWGPRCE 1287
            GG C+          F C C   F G RCE
Sbjct: 1309 GGLCQDLLN-----KFQCLCDVAFAGERCE 1333



 Score =  134 bits (338), Expect = 8e-31
 Identities = 69/205 (33%), Positives = 100/205 (48%), Gaps = 15/205 (7%)

Query: 240  CPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
            C  + CL+GG C D  ++Y+C CP  W+G+ C  ++DEC   P   H  G C + +  + 
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIH--GNCSDRVAAYH 1199

Query: 300  CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLC---HLDDACV 356
            C C  G+TG +C  +ID+C +  C +GATC      + C C    TG  C    L     
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVC 1259

Query: 357  SN-----PCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT 411
             N      C+    C          C C PGFTG  C++D+DEC+  ++PC + G C + 
Sbjct: 1260 GNEKTNLTCYNGGNC--TEFQTELKCMCRPGFTGEWCEKDIDECA--SDPCVNGGLCQDL 1315

Query: 412  QGSFLCQCGRGYTGPRCETDVNECL 436
               F C C   + G RCE D+ + L
Sbjct: 1316 LNKFQCLCDVAFAGERCEVDLADDL 1340



 Score =  134 bits (336), Expect = 1e-30
 Identities = 74/205 (36%), Positives = 96/205 (46%), Gaps = 13/205 (6%)

Query: 699  CAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFH 757
            C   PC HG  C D    + C C  GWSG  C  ++  D C S PC   G CS     +H
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNI--DECFSNPC-IHGNCSDRVAAYH 1199

Query: 758  CTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD---VDE 813
            CTC PG  G  CE+ +  C  + C +G  C S       C C   + G  C+Q       
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYS-CLCFGNFTGKFCRQSRLPSTV 1258

Query: 814  CAGPAP---CGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870
            C        C   G CT       C C  G+TG  C++DI++C  +PC+NGG CQD +  
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318

Query: 871  FSCSCLPGFAGPRCARDV-DECLSN 894
            F C C   FAG RC  D+ D+ +S+
Sbjct: 1319 FQCLCDVAFAGERCEVDLADDLISD 1343



 Score =  131 bits (330), Expect = 7e-30
 Identities = 73/206 (35%), Positives = 94/206 (45%), Gaps = 23/206 (11%)

Query: 1126 CASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDL 1185
            C S PC HGG+C D+ + Y CSCP G  G  CE+N D+C   P       C+H G C D 
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-------CIH-GNCSDR 1194

Query: 1186 VGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQT 1245
            V  + CTC PGYTG+ CE DI+ C+S  C  A+   C+    G + CLC   F+G  C+ 
Sbjct: 1195 VAAYHCTCEPGYTGVNCEVDIDNCQSHQC--ANGATCISHTNG-YSCLCFGNFTGKFCRQ 1251

Query: 1246 VLSP---CESQP----CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQC 1298
               P   C ++     C +GG C             C C   F G  CE+    C    C
Sbjct: 1252 SRLPSTVCGNEKTNLTCYNGGNCTEFQ-----TELKCMCRPGFTGEWCEKDIDECASDPC 1306

Query: 1299 PVGVPCQQTPRGPRCACPPGLSGPSC 1324
              G  CQ      +C C    +G  C
Sbjct: 1307 VNGGLCQDLLNKFQCLCDVAFAGERC 1332



 Score =  124 bits (311), Expect = 1e-27
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 16/203 (7%)

Query: 45   DGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTAR 103
            + +PC +GG C  + S    C CP GW G+ C+L  D C S PC   G C   V A    
Sbjct: 1144 NSNPCLHGGNCEDIYS-SYHCSCPLGWSGKHCELNIDECFSNPCI-HGNCSDRVAA---- 1197

Query: 104  FSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD---- 158
            + C C  G+ G +C +  D C S  CA+GA C    +G + C C   + G+ CR      
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNG-YSCLCFGNFTGKFCRQSRLPS 1256

Query: 159  --VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216
                  +    C +GG C       +C C  G+TG  CE     CA  PC NGG C+   
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316

Query: 217  DLTYDCACLPGFEGQNCEVNVDD 239
            +  + C C   F G+ CEV++ D
Sbjct: 1317 N-KFQCLCDVAFAGERCEVDLAD 1338



 Score =  110 bits (275), Expect = 2e-23
 Identities = 61/215 (28%), Positives = 91/215 (42%), Gaps = 26/215 (12%)

Query: 1176 CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
            CLH G C D+   + C+CP G++G  CE +I+EC S  C   +  D +      + C C 
Sbjct: 1148 CLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRV----AAYHCTCE 1203

Query: 1236 AGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER------- 1288
             G++G  C+  +  C+S  C +G  C           ++C C   F G  C +       
Sbjct: 1204 PGYTGVNCEVDIDNCQSHQCANGATCISHTNG-----YSCLCFGNFTGKFCRQSRLPSTV 1258

Query: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG 1348
                   L C  G  C +     +C C PG +G  C              CA+ PC++GG
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEK--------DIDECASDPCVNGG 1310

Query: 1349 SCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSE 1383
             C+   L   F+C C   + G RCE   A   +S+
Sbjct: 1311 LCQD--LLNKFQCLCDVAFAGERCEVDLADDLISD 1343



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 53/190 (27%), Positives = 73/190 (38%), Gaps = 18/190 (9%)

Query: 1206 INECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSP 1265
            +N C S  C   H  +C +D    + C C  G+SG  C+  +  C S PC HG  C    
Sbjct: 1140 LNVCNSNPC--LHGGNC-EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRV 1195

Query: 1266 GPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR 1325
                   + C C   + G  CE    +C+  QC  G  C     G  C C    +G  CR
Sbjct: 1196 A-----AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCR 1250

Query: 1326 S--FPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSE 1383
                P +  G    +     C +GG+C         +C C  G+TG  CE      E + 
Sbjct: 1251 QSRLPSTVCGNEKTNLT---CYNGGNC--TEFQTELKCMCRPGFTGEWCEKD--IDECAS 1303

Query: 1384 EPRCPRAACQ 1393
            +P      CQ
Sbjct: 1304 DPCVNGGLCQ 1313



 Score = 68.2 bits (165), Expect = 9e-11
 Identities = 30/69 (43%), Positives = 42/69 (60%), Gaps = 1/69 (1%)

Query: 471 DECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYE 530
           + C+S+PC NGGVC  R + FSC+CP+  SG  C+ +V  C  +PC +GA+C     G+E
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 531 CRCAEGFEG 539
           C     F G
Sbjct: 948 CIANAVFNG 956



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 1/74 (1%)

Query: 433 NECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFS 492
           N C S PC N   C  R   F+C C A  +G  CE ++  C  SPC +G  C+  + GF 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 493 CTCPSGFSGSTCQL 506
           C   + F+G + Q+
Sbjct: 948 CIANAVFNGQSGQI 961



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 21/52 (40%), Positives = 30/52 (57%)

Query: 736 DACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCE 787
           ++C+S PC  GG C S    F C+CP    G+ CE +  C  +PC HG +C+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQ 940



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query: 584 DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYD 642
           + C+S PC +GG C    D + C CP+ T+G  CE  +  C  +PC  G  C+  +  ++
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 643 CVCQPGFTG 651
           C+    F G
Sbjct: 948 CIANAVFNG 956



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 3/68 (4%)

Query: 966  CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCL 1023
            C S PC +GGVC +    F C+C    +G  C+  V WC   PC +G +C  V  G  C+
Sbjct: 891  CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECI 949

Query: 1024 CPPGWSGR 1031
                ++G+
Sbjct: 950  ANAVFNGQ 957



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 26/73 (35%), Positives = 28/73 (38%), Gaps = 1/73 (1%)

Query: 928  CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCT 987
            C  + C NGG C    + FSC C P  T      E   C   PC HG  C     GF C 
Sbjct: 891  CKSNPCHNGGVCHSRWDDFSCSC-PALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECI 949

Query: 988  CLESFTGPQCQTL 1000
                F G   Q L
Sbjct: 950  ANAVFNGQSGQIL 962



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 30/83 (36%), Positives = 36/83 (43%), Gaps = 5/83 (6%)

Query: 72  VGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHG 131
           V + C  ++ C S PC   GVC S        FSC CP    G  C     C  SPC HG
Sbjct: 881 VTQGCAGDNSCKSNPCHNGGVCHSR----WDDFSCSCPALTSGKACEEVQWCGFSPCPHG 936

Query: 132 ARCSVGPDGRFLCSCPPGYQGRS 154
           A+C     G F C     + G+S
Sbjct: 937 AQCQPVLQG-FECIANAVFNGQS 958



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 15/108 (13%)

Query: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262
           P+P  N        ++T  CA      G N       C  + C NGG C    + ++C C
Sbjct: 866 PNPTNNASLNPVLVNVTQGCA------GDN------SCKSNPCHNGGVCHSRWDDFSCSC 913

Query: 263 PPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGES 310
           P   +G+ C E+V  C   P  C +G  C   L G  C+    + G+S
Sbjct: 914 PALTSGKAC-EEVQWCGFSP--CPHGAQCQPVLQGFECIANAVFNGQS 958



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 24/69 (34%), Positives = 29/69 (42%), Gaps = 2/69 (2%)

Query: 851 NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT-CTDHVASFT 909
           N C  NPC NGG C      FSCSC P     +   +V  C  +PC  G  C   +  F 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSC-PALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 910 CTCPPGYGG 918
           C     + G
Sbjct: 948 CIANAVFNG 956



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 1/59 (1%)

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLC 1146
            C + PC +GG C      + C C    +G  CE +V  C   PC HG  C  ++  + C
Sbjct: 891  CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFEC 948



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 29/87 (33%), Positives = 34/87 (39%), Gaps = 14/87 (16%)

Query: 1113 GYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDS 1172
            G  GDN       C S PC +GG C      + CSCP  T G  CE     CG  P    
Sbjct: 884  GCAGDN------SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSP---- 932

Query: 1173 GPRCLHNGTCVDLVGGFRCTCPPGYTG 1199
               C H   C  ++ GF C     + G
Sbjct: 933  ---CPHGAQCQPVLQGFECIANAVFNG 956



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 4/83 (4%)

Query: 153 RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC 212
           + C  D + C+   PC +GG C +    F C CPA  +G  CE     C  SPC +G  C
Sbjct: 883 QGCAGD-NSCK-SNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQC 939

Query: 213 RQSGDLTYDCACLPGFEGQNCEV 235
            Q     ++C     F GQ+ ++
Sbjct: 940 -QPVLQGFECIANAVFNGQSGQI 961



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 4/70 (5%)

Query: 269 QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT 328
           Q C  D + C+  P  CHNGG C +     SC C    +G++C + +  C  + C HGA 
Sbjct: 883 QGCAGD-NSCKSNP--CHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQ 938

Query: 329 CHDRVASFYC 338
           C   +  F C
Sbjct: 939 CQPVLQGFEC 948



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 5/77 (6%)

Query: 349 CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRC 408
           C  D++C SNPCH   +C +   +    C+CP   +G AC ++V  C  G +PC H  +C
Sbjct: 885 CAGDNSCKSNPCHNGGVCHSRWDD--FSCSCPALTSGKAC-EEVQWC--GFSPCPHGAQC 939

Query: 409 VNTQGSFLCQCGRGYTG 425
                 F C     + G
Sbjct: 940 QPVLQGFECIANAVFNG 956



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 547 DDCSPDPCHHGR-CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
           + C  +PCH+G  C      FSC+C    +G  CE +V  C   PC HG +C  ++  + 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 606 C 606
           C
Sbjct: 948 C 948



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 25/74 (33%), Positives = 34/74 (45%), Gaps = 3/74 (4%)

Query: 884 CARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDG 942
           CA D + C SNPC   G C      F+C+CP    G  CE ++  C  S C +G  C   
Sbjct: 885 CAGD-NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPV 942

Query: 943 VNSFSCLCRPGYTG 956
           +  F C+    + G
Sbjct: 943 LQGFECIANAVFNG 956



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 2/69 (2%)

Query: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFS 567
           + C S PC NG  C  + D + C C     G  C+  V  C   PC HG +C   +  F 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 568 CACAPGYTG 576
           C     + G
Sbjct: 948 CIANAVFNG 956



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 23/69 (33%), Positives = 29/69 (42%), Gaps = 2/69 (2%)

Query: 659 NECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFR 717
           N C S+PC  GG C    + F C CP  +    C      C   PC HG  C     GF 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 718 CVCEPGWSG 726
           C+    ++G
Sbjct: 948 CIANAVFNG 956



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 2/62 (3%)

Query: 622 DDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFR 680
           + C SNPC   GVC    + + C C    +G  C  E+  C  SPC  G  C     GF 
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 681 CL 682
           C+
Sbjct: 948 CI 949



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 1/64 (1%)

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
            C  GG C        C CP   +G  CE EV  C   PC HG  C+  + G+ C     +
Sbjct: 896  CHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECIANAVF 954

Query: 1115 NGDN 1118
            NG +
Sbjct: 955  NGQS 958



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 117 CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLN 176
           C+  + C S+PC +G  C    D  F CSCP    G++C  +V  C    PC HG  C  
Sbjct: 885 CAGDNSCKSNPCHNGGVCHSRWDD-FSCSCPALTSGKAC-EEVQWCGF-SPCPHGAQCQP 941

Query: 177 TPGSFRCQCPAGYTG 191
               F C   A + G
Sbjct: 942 VLQGFECIANAVFNG 956



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 5/95 (5%)

Query: 369 NPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRC 428
           NP N  ++       T G    +    S  +NPC + G C +    F C C    +G  C
Sbjct: 867 NPTNNASLNPVLVNVTQGCAGDN----SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC 922

Query: 429 ETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTG 463
           E +V  C   PC + A C   +  F CI  A F G
Sbjct: 923 E-EVQWCGFSPCPHGAQCQPVLQGFECIANAVFNG 956



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 5/72 (6%)

Query: 775 CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI-CTNLAGSF 833
           C  NPC +GG C S       CSCP    G  C ++V  C G +PC PHG  C  +   F
Sbjct: 891 CKSNPCHNGGVCHSRWDDFS-CSCPALTSGKAC-EEVQWC-GFSPC-PHGAQCQPVLQGF 946

Query: 834 SCTCHGGYTGPS 845
            C  +  + G S
Sbjct: 947 ECIANAVFNGQS 958



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 1/63 (1%)

Query: 819 PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPG 878
           PC   G+C +    FSC+C    +G +C +++  C  +PC +G  CQ  +  F C     
Sbjct: 895 PCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQPVLQGFECIANAV 953

Query: 879 FAG 881
           F G
Sbjct: 954 FNG 956



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 11/65 (16%)

Query: 1202 CEADINECRSGACH---AAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHG 1258
            C  D N C+S  CH     H+R         F C C A  SG  C+ V   C   PC HG
Sbjct: 885  CAGD-NSCKSNPCHNGGVCHSR------WDDFSCSCPALTSGKACEEV-QWCGFSPCPHG 936

Query: 1259 GQCRP 1263
             QC+P
Sbjct: 937  AQCQP 941



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 17/51 (33%), Positives = 23/51 (45%)

Query: 316 DDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAIC 366
           + C +  C +G  CH R   F C+CP   +G  C     C  +PC   A C
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQC 939



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 24/74 (32%), Positives = 30/74 (40%), Gaps = 6/74 (8%)

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
            C+S PC +GG C           F+C C     G  CE V + C    CP G  CQ   +
Sbjct: 891  CKSNPCHNGGVCHSRWDD-----FSCSCPALTSGKACEEV-QWCGFSPCPHGAQCQPVLQ 944

Query: 1310 GPRCACPPGLSGPS 1323
            G  C      +G S
Sbjct: 945  GFECIANAVFNGQS 958



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 14/30 (46%), Positives = 18/30 (60%)

Query: 399 ANPCEHLGRCVNTQGSFLCQCGRGYTGPRC 428
           + PC+  GRC+N   S+ C C R Y GP C
Sbjct: 678 SQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 6/66 (9%)

Query: 1176 CLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGAC-HAAHTRDCLQDPGGGFRCLC 1234
            C + G C      F C+CP   +G  CE ++  C    C H A  +  LQ    GF C+ 
Sbjct: 896  CHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQ----GFECIA 950

Query: 1235 HAGFSG 1240
            +A F+G
Sbjct: 951  NAVFNG 956



 Score = 37.7 bits (86), Expect = 0.13
 Identities = 17/39 (43%), Positives = 22/39 (56%), Gaps = 5/39 (12%)

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288
            CESQPCQ  G+C         L++ C C +P+ GP C R
Sbjct: 676  CESQPCQSRGRC-----INLWLSYQCDCHRPYEGPNCLR 709



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 21/75 (28%), Positives = 28/75 (37%), Gaps = 4/75 (5%)

Query: 699 CAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFH 757
           C   PC +G +C+     F C C    SG  C +      C   PC  G  C     GF 
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEV---QWCGFSPCPHGAQCQPVLQGFE 947

Query: 758 CTCPPGVQGRQCELL 772
           C       G+  ++L
Sbjct: 948 CIANAVFNGQSGQIL 962



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 15/34 (44%), Positives = 19/34 (55%)

Query: 584 DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNC 617
           D C SQPC+  G+C++L   Y C C     G NC
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 15/34 (44%), Positives = 17/34 (50%)

Query: 1086 DPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNC 1119
            D C +QPCQ  G C      Y C+C   Y G NC
Sbjct: 674  DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 14/28 (50%), Positives = 16/28 (57%)

Query: 819 PCGPHGICTNLAGSFSCTCHGGYTGPSC 846
           PC   G C NL  S+ C CH  Y GP+C
Sbjct: 680 PCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 13/35 (37%), Positives = 20/35 (57%)

Query: 735 RDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC 769
           +D CESQPC++ G C +  + + C C    +G  C
Sbjct: 673 KDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 28/96 (29%), Positives = 37/96 (38%), Gaps = 5/96 (5%)

Query: 19  PPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQL 78
           P P    +L  +L+    G A       +PC NGG C      + +C CP    G+ C+ 
Sbjct: 866 PNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWD-DFSCSCPALTSGKACEE 924

Query: 79  EDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRG 114
              C   PC     CQ  V+ G   F C     F G
Sbjct: 925 VQWCGFSPCPHGAQCQ-PVLQG---FECIANAVFNG 956



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 14/25 (56%), Positives = 15/25 (60%)

Query: 1124 DECASQPCQHGGSCIDLVARYLCSC 1148
            D C SQPCQ  G CI+L   Y C C
Sbjct: 674  DWCESQPCQSRGRCINLWLSYQCDC 698



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 18/61 (29%), Positives = 23/61 (37%), Gaps = 9/61 (14%)

Query: 1292 SCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCR 1351
            SC+   C  G  C        C+CP   SG +C              C  +PC HG  C+
Sbjct: 890  SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQW---------CGFSPCPHGAQCQ 940

Query: 1352 P 1352
            P
Sbjct: 941  P 941



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

Query: 76  CQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
           C  +D C S PC  RG C +  ++    + C C R + GP+C
Sbjct: 670 CVRKDWCESQPCQSRGRCINLWLS----YQCDCHRPYEGPNC 707



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 13/36 (36%), Positives = 20/36 (55%)

Query: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544
           D C S PC++  +C++    Y+C C   +EG  C R
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLR 709



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 14/34 (41%), Positives = 17/34 (50%), Gaps = 2/34 (5%)

Query: 1002 DWCSRQPCQNGGRCVQ--TGAYCLCPPGWSGRLC 1033
            DWC  QPCQ+ GRC+       C C   + G  C
Sbjct: 674  DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 12/29 (41%), Positives = 17/29 (58%)

Query: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLC 194
           +PC+  G C+N   S++C C   Y GP C
Sbjct: 679 QPCQSRGRCINLWLSYQCDCHRPYEGPNC 707



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 12/35 (34%), Positives = 18/35 (51%)

Query: 853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARD 887
           C+  PC + G C +   S+ C C   + GP C R+
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLRE 710


>gi|112420992 crumbs homolog 2 [Homo sapiens]
          Length = 1285

 Score =  336 bits (862), Expect = 1e-91
 Identities = 201/618 (32%), Positives = 260/618 (42%), Gaps = 97/618 (15%)

Query: 354 ACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQG 413
           AC S+PC     C      G    TC P    G   Q          PC H   CV  QG
Sbjct: 41  ACASDPCAPGTECQATESGGY---TCGPMEPRGCATQ----------PCHHGALCV-PQG 86

Query: 414 ----SFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVD 469
                F C C  G+ GPRCE D++EC S PC + ATC +   ++ C C  G+ G  CE++
Sbjct: 87  PDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146

Query: 470 IDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGY 529
           +DEC S+PC++GG C D V  F C C  G+ G+ CQLD+DEC S PC +G  C D  +G+
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGF 206

Query: 530 ECRCA-EGFEGTLCDRNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECR 587
            C CA  G+EGT C+R V +C+  PC H+  C++G+ SF C C PGY+G  CE   DEC 
Sbjct: 207 RCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECA 266

Query: 588 SQPCRHGGKCLDLVDK---------------------YLCRCPSGTTGVNCEVNIDDCAS 626
           S PC+HGG+CL   D                      +LC CP G  G +C V +D+CAS
Sbjct: 267 SSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECAS 326

Query: 627 NPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPP 685
            PC   G C+D  N + C C  G+ GP C  +++EC S PC  GG+C D   G+ C CP 
Sbjct: 327 RPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPE 386

Query: 686 -----GSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACES 740
                     L     H C        I       + C C PG  GP C Q+        
Sbjct: 387 TWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAG 446

Query: 741 QPCRA---GGTCSSDGMGFHCTCPPGVQGR-----------------QCELLSPCT---- 776
            P +A    G      + F  T P G                     Q  L S  T    
Sbjct: 447 SPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLV 506

Query: 777 ---PNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSF 833
              P+   + G        L + +         C   +   +GP         T L    
Sbjct: 507 LRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGI 566

Query: 834 SCTCHGGYTGPSCDQDI-----------------------NDCDPNPCLNGGSCQDGVGS 870
           S    G  T   C QD+                         C P PC++GGSC D    
Sbjct: 567 SSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERREQCRPLPCVHGGSCVDLWTH 626

Query: 871 FSCSCLPGFAGPRCARDV 888
           F C C     GP CA ++
Sbjct: 627 FRCDCARPHRGPTCADEI 644



 Score =  300 bits (769), Expect = 8e-81
 Identities = 168/495 (33%), Positives = 212/495 (42%), Gaps = 88/495 (17%)

Query: 737  ACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVC 796
            AC S PC  G  C +   G +   P   +G        C   PC HG  C          
Sbjct: 41   ACASDPCAPGTECQATESGGYTCGPMEPRG--------CATQPCHHGALC---------- 82

Query: 797  SCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN 856
              PQG               P P G           F C C  G+ GP C+ DI++C   
Sbjct: 83   -VPQG---------------PDPTG-----------FRCYCVPGFQGPRCELDIDECASR 115

Query: 857  PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPG 915
            PC +G +C++    + C C  G+AG  C  +VDEC S PC   G+C D V SF C C PG
Sbjct: 116  PCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPG 175

Query: 916  YGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCR-PGYTGAHCQHEADPCLSRPCLHG 974
            YGG  C+ DL +C    C +GGTC D VN F C C   GY G HC+ E   C S PC H 
Sbjct: 176  YGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHN 235

Query: 975  GVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ----------------- 1017
              C      FRC C   ++G  C+   D C+  PCQ+GGRC+Q                 
Sbjct: 236  ASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGA 295

Query: 1018 ------TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV 1071
                   G  C CPPG+ G  C +    C              C  GG C D  +   C 
Sbjct: 296  FSFRHAAGFLCHCPPGFEGADCGVEVDECASRP----------CLNGGHCQDLPNGFQCH 345

Query: 1072 CPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
            CP+G  G  CE++VD CL+ PC HGGTC   + GY+C C   + G +C   +  C    C
Sbjct: 346  CPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTC 405

Query: 1132 QHGGSCIDL----VARYLCSCPPGTLGVLCEINED-DCGPGPPLDSGPRCLHNGTCVDLV 1186
                +CI +    V  Y+C CPPGT G  C  N       G P+ +    +  G  + L 
Sbjct: 406  PLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQAS---VPAGGPLGLA 462

Query: 1187 GGFRCTCPPGYTGLR 1201
              FR T P G    R
Sbjct: 463  LRFRTTLPAGTLATR 477



 Score =  300 bits (768), Expect = 1e-80
 Identities = 156/408 (38%), Positives = 197/408 (48%), Gaps = 49/408 (12%)

Query: 661  CASSPCGEGGSCVDGENG-FRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDA---PGG 715
            CAS PC  G  C   E+G + C    G + P        CA +PC HG +C      P G
Sbjct: 42   CASDPCAPGTECQATESGGYTC----GPMEP------RGCATQPCHHGALCVPQGPDPTG 91

Query: 716  FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSP 774
            FRC C PG+ GPRC   +  D C S+PC  G TC +    + C CP G  G  CE+ +  
Sbjct: 92   FRCYCVPGFQGPRCELDI--DECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDE 149

Query: 775  CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFS 834
            C   PC HGG C    G    C C  G+ G RCQ D+DEC    PC   G C +L   F 
Sbjct: 150  CASAPCLHGGSCLDGVGSFR-CVCAPGYGGTRCQLDLDECQSQ-PCAHGGTCHDLVNGFR 207

Query: 835  CTCHG-GYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLS 893
            C C G GY G  C++++ +C   PC +  SC +G+GSF C C PG++G  C  D DEC S
Sbjct: 208  CDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECAS 267

Query: 894  NPCGPG-TCTD---------------------HVASFTCTCPPGYGGFHCEQDLPDCSPS 931
            +PC  G  C                       H A F C CPPG+ G  C  ++ +C+  
Sbjct: 268  SPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASR 327

Query: 932  SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLES 991
             C NGG C D  N F C C  GY G  C+ + D CLS PCLHGG CS    G+ C C E+
Sbjct: 328  PCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPET 387

Query: 992  FTGPQCQTLVDWCSRQPCQNGGRCV---QTGAY---CLCPPGWSGRLC 1033
            + G  C   +  C    C     C+   ++G +   C CPPG  G  C
Sbjct: 388  WGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435



 Score =  298 bits (764), Expect = 3e-80
 Identities = 152/413 (36%), Positives = 201/413 (48%), Gaps = 44/413 (10%)

Query: 120 PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-- 177
           P  C S PCA G  C     G + C      + R C +        +PC HG  C+    
Sbjct: 39  PSACASDPCAPGTECQATESGGYTCG---PMEPRGCAT--------QPCHHGALCVPQGP 87

Query: 178 -PGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVN 236
            P  FRC C  G+ GP CE     CA  PC +G TCR   D  Y+C C  G+ G  CE+ 
Sbjct: 88  DPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLAD-RYECHCPLGYAGVTCEME 146

Query: 237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLG 296
           VD+C    CL+GG+C+DGV ++ C C P + G  C  D+DECQ QP  C +GGTC + + 
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQP--CAHGGTCHDLVN 204

Query: 297 GHSCVCV-NGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DA 354
           G  C C   G+ G  C + + +CA+A C H A+C + + SF C C  G +G LC +D D 
Sbjct: 205 GFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDE 264

Query: 355 CVSNPCHEDAIC--DTNPV-----------------NGRAICTCPPGFTGGACDQDVDEC 395
           C S+PC     C   ++P                      +C CPPGF G  C  +VDEC
Sbjct: 265 CASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDEC 324

Query: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
           +  + PC + G C +    F C C  GY GP CE DV+ECLS PC +  TC D +  + C
Sbjct: 325 A--SRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYIC 382

Query: 456 ICMAGFTGTYCEVDIDECQSSPCVNGGVC----KDRVNGFSCTCPSGFSGSTC 504
            C   + G  C V +  CQ   C     C    +  V+ + C CP G  G  C
Sbjct: 383 RCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435



 Score =  283 bits (723), Expect = 2e-75
 Identities = 149/411 (36%), Positives = 191/411 (46%), Gaps = 66/411 (16%)

Query: 539 GTLCDRNVDDCSPD-----------------------------PCHHGR-CV---DGIAS 565
           GT+       C+ D                             PCHHG  CV        
Sbjct: 32  GTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTG 91

Query: 566 FSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCA 625
           F C C PG+ G RCE  +DEC S+PC HG  C +L D+Y C CP G  GV CE+ +D+CA
Sbjct: 92  FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151

Query: 626 SNPCTF-GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCP 684
           S PC   G C DG+  + CVC PG+ G  C ++++EC S PC  GG+C D  NGFRC C 
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCA 211

Query: 685 -PGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRCSQSLARDACESQP 742
             G     C      CA  PC H   C +  G FRC+C PG+SG  C   +  D C S P
Sbjct: 212 GTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELC--EVDEDECASSP 269

Query: 743 CRAGGTC--SSD-------------------GMGFHCTCPPGVQGRQCEL-LSPCTPNPC 780
           C+ GG C   SD                     GF C CPPG +G  C + +  C   PC
Sbjct: 270 CQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPC 329

Query: 781 EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG 840
            +GG C+  P     C CP G+ GP C++DVDEC    PC   G C++    + C C   
Sbjct: 330 LNGGHCQDLPNGFQ-CHCPDGYAGPTCEEDVDECLSD-PCLHGGTCSDTVAGYICRCPET 387

Query: 841 YTGPSCDQDINDCDPNPCLNGGSC----QDGVGSFSCSCLPGFAGPRCARD 887
           + G  C   +  C  + C    +C    + GV S+ C C PG  GP C ++
Sbjct: 388 WGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQN 438



 Score =  270 bits (691), Expect = 9e-72
 Identities = 143/434 (32%), Positives = 202/434 (46%), Gaps = 66/434 (15%)

Query: 925  LPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP--CLSRPCLHGGVCSAAHP 982
            +P   PS+C +   C  G       C+   +G +     +P  C ++PC HG +C    P
Sbjct: 34   VPSEPPSACASD-PCAPGTE-----CQATESGGYTCGPMEPRGCATQPCHHGALCVPQGP 87

Query: 983  ---GFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCLCPPGWSGRLCDIRS 1037
               GFRC C+  F GP+C+  +D C+ +PC +G  C  +     C CP G++G  C++  
Sbjct: 88   DPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEV 147

Query: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGG 1097
              C  A           C  GG C+D   S  CVC  G  G+ C+ ++D C +QPC HGG
Sbjct: 148  DECASAP----------CLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGG 197

Query: 1098 TCRGYMGGYMCECL-PGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVL 1156
            TC   + G+ C+C   GY G +CE +V ECAS PC+H  SC++ +  + C C PG  G L
Sbjct: 198  TCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGEL 257

Query: 1157 CEINEDDCGPGPPLDSGPRCLHNGTCVDL---------------------VGGFRCTCPP 1195
            CE++ED+C   P       C H G C+                         GF C CPP
Sbjct: 258  CEVDEDECASSP-------CQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPP 310

Query: 1196 GYTGLRCEADINECRSGAC-HAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQP 1254
            G+ G  C  +++EC S  C +  H     QD   GF+C C  G++GP C+  +  C S P
Sbjct: 311  GFEGADCGVEVDECASRPCLNGGHC----QDLPNGFQCHCPDGYAGPTCEEDVDECLSDP 366

Query: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPC----QQTPRG 1310
            C HGG C  +        + C C + + G  C      C+   CP+   C    +     
Sbjct: 367  CLHGGTCSDTVAG-----YICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHS 421

Query: 1311 PRCACPPGLSGPSC 1324
              C CPPG  GP C
Sbjct: 422  YVCHCPPGTHGPFC 435



 Score =  263 bits (672), Expect = 1e-69
 Identities = 152/449 (33%), Positives = 198/449 (44%), Gaps = 62/449 (13%)

Query: 853  CDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT-CTDH---VAS 907
            C  +PC  G  CQ    G ++C       GP   R    C + PC  G  C         
Sbjct: 42   CASDPCAPGTECQATESGGYTC-------GPMEPRG---CATQPCHHGALCVPQGPDPTG 91

Query: 908  FTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCL 967
            F C C PG+ G  CE D+ +C+   C +G TC +  + + C C  GY G  C+ E D C 
Sbjct: 92   FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151

Query: 968  SRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC--VQTGAYCLCP 1025
            S PCLHGG C      FRC C   + G +CQ  +D C  QPC +GG C  +  G  C C 
Sbjct: 152  SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCA 211

Query: 1026 -PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084
              G+ G  C+   L C  A           C+    C++   S  C+C  G +G  CE +
Sbjct: 212  GTGYEGTHCEREVLECASAP----------CEHNASCLEGLGSFRCLCWPGYSGELCEVD 261

Query: 1085 VDPCLAQPCQHGGTCRG---------------------YMGGYMCECLPGYNGDNCEDDV 1123
             D C + PCQHGG C                       +  G++C C PG+ G +C  +V
Sbjct: 262  EDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEV 321

Query: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183
            DECAS+PC +GG C DL   + C CP G  G  CE + D+C   P       CLH GTC 
Sbjct: 322  DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDP-------CLHGGTCS 374

Query: 1184 DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPG-GGFRCLCHAGFSGPR 1242
            D V G+ C CP  + G  C   +  C+   C  A T   + + G   + C C  G  GP 
Sbjct: 375  DTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPF 434

Query: 1243 C--QTVLSPCESQPCQHGGQCRPSPGPGG 1269
            C   T  S     P Q      P+ GP G
Sbjct: 435  CGQNTTFSVMAGSPIQ---ASVPAGGPLG 460



 Score =  261 bits (666), Expect = 7e-69
 Identities = 148/407 (36%), Positives = 181/407 (44%), Gaps = 58/407 (14%)

Query: 1004 CSRQPCQNGGRC--VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061
            C+  PC  G  C   ++G Y   P    G      + PC   A         LC   G  
Sbjct: 42   CASDPCAPGTECQATESGGYTCGPMEPRG----CATQPCHHGA---------LCVPQGP- 87

Query: 1062 VDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCED 1121
              + +   C C  G  G  CE ++D C ++PC HG TCR     Y C C  GY G  CE 
Sbjct: 88   --DPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEM 145

Query: 1122 DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGT 1181
            +VDECAS PC HGGSC+D V  + C C PG  G  C+++ D+C   P       C H GT
Sbjct: 146  EVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQP-------CAHGGT 198

Query: 1182 CVDLVGGFRCTCP-PGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSG 1240
            C DLV GFRC C   GY G  CE ++ EC S  C   H   CL+   G FRCLC  G+SG
Sbjct: 199  CHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCE--HNASCLEGL-GSFRCLCWPGYSG 255

Query: 1241 PRCQTVLSPCESQPCQHGGQC--RPSPGPGGGLT--------------FTCHCAQPFWGP 1284
              C+     C S PCQHGG+C  R  P   GG+               F CHC   F G 
Sbjct: 256  ELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGA 315

Query: 1285 RCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPC 1344
             C      C    C  G  CQ  P G +C CP G +GP+C              C + PC
Sbjct: 316  DCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEE--------DVDECLSDPC 367

Query: 1345 LHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAA 1391
            LHGG+C  +     + C C + W G  C          +   CP AA
Sbjct: 368  LHGGTC--SDTVAGYICRCPETWGGRDCSVQLTG---CQGHTCPLAA 409



 Score =  249 bits (635), Expect = 3e-65
 Identities = 153/433 (35%), Positives = 196/433 (45%), Gaps = 54/433 (12%)

Query: 28  PLLLLLAGPGAAAPPCLDGS-PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP 86
           P L LLAG   + PP    S PCA G  C    S    C    G +  R     PCH G 
Sbjct: 25  PALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTC----GPMEPRGCATQPCHHGA 80

Query: 87  -CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLC 144
            C  +G   +        F C C  GF+GP C L  D C S PC HGA C    D R+ C
Sbjct: 81  LCVPQGPDPTG-------FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLAD-RYEC 132

Query: 145 SCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPS 204
            CP GY G +C  +VDEC    PC HGG+CL+  GSFRC C  GY G  C+     C   
Sbjct: 133 HCPLGYAGVTCEMEVDEC-ASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQ 191

Query: 205 PCRNGGTCRQSGDLT--YDCACL-PGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQ 261
           PC +GGTC    DL   + C C   G+EG +CE  V +C    C +  +C++G+ ++ C 
Sbjct: 192 PCAHGGTCH---DLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCL 248

Query: 262 CPPEWTGQFCTEDVDECQLQPNACHNGGTC---------------------FNTLGGHSC 300
           C P ++G+ C  D DEC   P  C +GG C                     F    G  C
Sbjct: 249 CWPGYSGELCEVDEDECASSP--CQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLC 306

Query: 301 VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNP 359
            C  G+ G  C   +D+CA+  C +G  C D    F C CP G  G  C  D D C+S+P
Sbjct: 307 HCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDP 366

Query: 360 CHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV----NTQGSF 415
           C     C ++ V G  IC CP  + G  C   +  C    + C     C+    +   S+
Sbjct: 367 CLHGGTC-SDTVAG-YICRCPETWGGRDCSVQLTGCQ--GHTCPLAATCIPIFESGVHSY 422

Query: 416 LCQCGRGYTGPRC 428
           +C C  G  GP C
Sbjct: 423 VCHCPPGTHGPFC 435



 Score =  181 bits (458), Expect = 1e-44
 Identities = 101/297 (34%), Positives = 128/297 (43%), Gaps = 70/297 (23%)

Query: 39  AAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQ--- 94
           A+ PCL G  C +G    +       C+C PG+ G RCQL+ D C S PCA  G C    
Sbjct: 151 ASAPCLHGGSCLDGVGSFR-------CVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLV 203

Query: 95  --------------------------------SSVVAGTARFSCRCPRGFRGPDCSLP-D 121
                                           +S + G   F C C  G+ G  C +  D
Sbjct: 204 NGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDED 263

Query: 122 PCLSSPCAHGARCSVGPD--------------------GRFLCSCPPGYQGRSCRSDVDE 161
            C SSPC HG RC    D                      FLC CPPG++G  C  +VDE
Sbjct: 264 ECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE 323

Query: 162 CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221
           C    PC +GG C + P  F+C CP GY GP CE     C   PC +GGTC  +    Y 
Sbjct: 324 C-ASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTV-AGYI 381

Query: 222 CACLPGFEGQNCEVNVDDCPGHRCLNGGTCV----DGVNTYNCQCPPEWTGQFCTED 274
           C C   + G++C V +  C GH C    TC+     GV++Y C CPP   G FC ++
Sbjct: 382 CRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQN 438



 Score =  116 bits (291), Expect = 2e-25
 Identities = 70/172 (40%), Positives = 80/172 (46%), Gaps = 19/172 (11%)

Query: 36   PGAAAP-------PCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPC 87
            PG  AP       P    SPC + G C  L     AC C PGW G RC+   DPCHS PC
Sbjct: 1045 PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHVDPCHSAPC 1103

Query: 88   AGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDP----CLSSPCAHGARCSVGPDGRFL 143
            A RG C +       RF CRCP GF GP C LP P     L+  C  G+ C  G      
Sbjct: 1104 A-RGRCHTHP---DGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAA-N 1158

Query: 144  CSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
            CSC  G  G+ C+     C    PC +GGTC    G   C C A ++G  CE
Sbjct: 1159 CSCLEGLAGQRCQVPTLPCE-ANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score =  112 bits (281), Expect = 3e-24
 Identities = 59/153 (38%), Positives = 76/153 (49%), Gaps = 8/153 (5%)

Query: 123  CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR 182
            C  SPC H   C    D  F C+C PG++G  C + VD C    PC  G    +  G F 
Sbjct: 1060 CAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHVDPCH-SAPCARGRCHTHPDGRFE 1117

Query: 183  CQCPAGYTGPLCENPAVP---CAPS-PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVD 238
            C+CP G+ GP C  P VP   C+ +  C +G  C + G    +C+CL G  GQ C+V   
Sbjct: 1118 CRCPPGFGGPRCRLP-VPSKECSLNVTCLDGSPC-EGGSPAANCSCLEGLAGQRCQVPTL 1175

Query: 239  DCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
             C  + CLNGGTC        C C   ++GQFC
Sbjct: 1176 PCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score =  110 bits (274), Expect = 2e-23
 Identities = 57/151 (37%), Positives = 71/151 (47%), Gaps = 9/151 (5%)

Query: 586  CRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCR---DGINRYD 642
            C   PC H G C DL D + C C  G  G  CE ++D C S PC  G C    DG  R++
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDG--RFE 1117

Query: 643  CVCQPGFTGPLCNVEI--NECA-SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC 699
            C C PGF GP C + +   EC+ +  C +G  C  G     C C  G     C  P+ PC
Sbjct: 1118 CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177

Query: 700  AHEPC-SHGICYDAPGGFRCVCEPGWSGPRC 729
               PC + G C  A G   C+C   +SG  C
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score =  108 bits (270), Expect = 6e-23
 Identities = 57/152 (37%), Positives = 76/152 (50%), Gaps = 6/152 (3%)

Query: 473  CQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG-YEC 531
            C  SPC++ G C+D  + F+C C  G+ G  C+  VD C S PC  G +C   PDG +EC
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118

Query: 532  RCAEGFEGTLCDRNV--DDCSPD-PCHHGR-CVDGIASFSCACAPGYTGTRCESQVDECR 587
            RC  GF G  C   V   +CS +  C  G  C  G  + +C+C  G  G RC+     C 
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178

Query: 588  SQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619
            + PC +GG C        C C +  +G  CEV
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210



 Score =  106 bits (264), Expect = 3e-22
 Identities = 64/185 (34%), Positives = 75/185 (40%), Gaps = 12/185 (6%)

Query: 1167 GPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDP 1226
            G P+ +   CLH+G C DL   F C C PG+ G RCEA ++ C S  C       C   P
Sbjct: 1056 GAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGR---CHTHP 1112

Query: 1227 GGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRP-SPGPGGGLTFTCHCAQPFWGPR 1285
             G F C C  GF GPRC+    P  S+ C     C   SP  GG     C C +   G R
Sbjct: 1113 DGRFECRCPPGFGGPRCRL---PVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQR 1169

Query: 1286 CERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSP-----PGASNASCA 1340
            C+     C    C  G  C+       C C    SG  C    G P     P    A  A
Sbjct: 1170 CQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPA 1229

Query: 1341 AAPCL 1345
            A  CL
Sbjct: 1230 ACACL 1234



 Score =  104 bits (260), Expect = 9e-22
 Identities = 51/147 (34%), Positives = 69/147 (46%), Gaps = 3/147 (2%)

Query: 400  NPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459
            +PC H G C +   +F C CG G+ GPRCE  V+ C S PC          G+F C C  
Sbjct: 1063 SPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPP 1122

Query: 460  GFTGTYCEVDI--DECQ-SSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC 516
            GF G  C + +   EC  +  C++G  C+      +C+C  G +G  CQ+    C + PC
Sbjct: 1123 GFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPC 1182

Query: 517  RNGAKCVDQPDGYECRCAEGFEGTLCD 543
             NG  C       EC C   F G  C+
Sbjct: 1183 LNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score =  104 bits (259), Expect = 1e-21
 Identities = 57/161 (35%), Positives = 72/161 (44%), Gaps = 11/161 (6%)

Query: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ--TGA 1020
            A  C   PCLH G C      F C C   + GP+C+  VD C   PC  G RC     G 
Sbjct: 1057 APVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGR 1115

Query: 1021 Y-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGS 1079
            + C CPPG+ G  C +  +P +E +  +       C  G  C     +  C C EG  G 
Sbjct: 1116 FECRCPPGFGGPRCRL-PVPSKECSLNV------TCLDGSPCEGGSPAANCSCLEGLAGQ 1168

Query: 1080 HCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
             C+    PC A PC +GGTCR   G   C C   ++G  CE
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score =  103 bits (258), Expect = 2e-21
 Identities = 53/151 (35%), Positives = 71/151 (47%), Gaps = 5/151 (3%)

Query: 814  CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSC 873
            CA P+PC   G C +L  +F+C C  G+ GP C+  ++ C   PC  G       G F C
Sbjct: 1060 CA-PSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFEC 1118

Query: 874  SCLPGFAGPRCARDV--DEC-LSNPCGPGT-CTDHVASFTCTCPPGYGGFHCEQDLPDCS 929
             C PGF GPRC   V   EC L+  C  G+ C     +  C+C  G  G  C+     C 
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178

Query: 930  PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
             + C NGGTC        C+C   ++G  C+
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score =  103 bits (257), Expect = 2e-21
 Identities = 65/170 (38%), Positives = 76/170 (44%), Gaps = 12/170 (7%)

Query: 685  PGSLPPLCLPPSHP-CAHEPCSH-GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQP 742
            PG+  P+      P CA  PC H G C D    F C C PGW GPRC   +  D C S P
Sbjct: 1045 PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHV--DPCHSAP 1102

Query: 743  CRAGGTCSSDGMG-FHCTCPPGVQGRQCELLSP---CTPN-PCEHGGRCESAPGQLPVCS 797
            C A G C +   G F C CPPG  G +C L  P   C+ N  C  G  CE        CS
Sbjct: 1103 C-ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGG-SPAANCS 1160

Query: 798  CPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD 847
            C +G  G RCQ     C    PC   G C    G   C C+  ++G  C+
Sbjct: 1161 CLEGLAGQRCQVPTLPCEA-NPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score =  103 bits (257), Expect = 2e-21
 Identities = 54/150 (36%), Positives = 69/150 (46%), Gaps = 4/150 (2%)

Query: 738  CESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVC 796
            C   PC   G C      F C C PG +G +CE  + PC   PC  G RC + P     C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118

Query: 797  SCPQGWQGPRCQQDVD--ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
             CP G+ GPRC+  V   EC+    C     C   + + +C+C  G  G  C      C+
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178

Query: 855  PNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
             NPCLNGG+C+   G   C C   F+G  C
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score =  103 bits (256), Expect = 3e-21
 Identities = 56/171 (32%), Positives = 73/171 (42%), Gaps = 8/171 (4%)

Query: 877  PGFAGPRCA-RDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCF 934
            PG   P    R    C  +PC   G C D   +F C C PG+ G  CE  +  C  + C 
Sbjct: 1045 PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCA 1104

Query: 935  NGGTCVDGVNSFSCLCRPGYTGAHCQ---HEADPCLSRPCLHGGVCSAAHPGFRCTCLES 991
             G         F C C PG+ G  C+      +  L+  CL G  C    P   C+CLE 
Sbjct: 1105 RGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEG 1164

Query: 992  FTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--CLCPPGWSGRLCDI-RSLP 1039
              G +CQ     C   PC NGG C   G    C+C   +SG+ C++ + LP
Sbjct: 1165 LAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLP 1215



 Score =  100 bits (250), Expect = 1e-20
 Identities = 56/153 (36%), Positives = 72/153 (47%), Gaps = 7/153 (4%)

Query: 624  CASNPCTF-GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCL 682
            CA +PC   G CRD  + + C C PG+ GP C   ++ C S+PC  G      +  F C 
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119

Query: 683  CPPGSLPPLC-LP-PSHPCA-HEPCSHGI-CYDAPGGFRCVCEPGWSGPRCSQSLARDAC 738
            CPPG   P C LP PS  C+ +  C  G  C        C C  G +G RC   +    C
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRC--QVPTLPC 1177

Query: 739  ESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL 771
            E+ PC  GGTC + G    C C     G+ CE+
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 9/162 (5%)

Query: 349  CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRC 408
            C     C  +PC  D  C    +     C C PG+ G  C+  VD C   + PC   GRC
Sbjct: 1054 CRGAPVCAPSPCLHDGAC--RDLFDAFACACGPGWEGPRCEAHVDPCH--SAPCAR-GRC 1108

Query: 409  -VNTQGSFLCQCGRGYTGPRCETDV--NEC-LSGPCRNQATCLDRIGQFTCICMAGFTGT 464
              +  G F C+C  G+ GPRC   V   EC L+  C + + C        C C+ G  G 
Sbjct: 1109 HTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168

Query: 465  YCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL 506
             C+V    C+++PC+NGG C+       C C + FSG  C++
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 52/153 (33%), Positives = 68/153 (44%), Gaps = 10/153 (6%)

Query: 435  CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNG-FSC 493
            C   PC +   C D    F C C  G+ G  CE  +D C S+PC  G  C    +G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGR-CHTHPDGRFEC 1118

Query: 494  TCPSGFSGSTCQLDV--DECA-STPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS 550
             CP GF G  C+L V   EC+ +  C +G+ C        C C EG  G  C      C 
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178

Query: 551  PDPCHHG---RCVDGIASFSCACAPGYTGTRCE 580
             +PC +G   R   G++   C C   ++G  CE
Sbjct: 1179 ANPCLNGGTCRAAGGVS--ECICNARFSGQFCE 1209



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 60/185 (32%), Positives = 80/185 (43%), Gaps = 19/185 (10%)

Query: 903  DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962
            +H AS+  T  P  G   C +  P C+PS C + G C D  ++F+C C PG+ G  C+  
Sbjct: 1039 EHFASWPGTPAPILG---C-RGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAH 1094

Query: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLV--DWCS-RQPCQNGGRCV--Q 1017
             DPC S PC  G   +     F C C   F GP+C+  V    CS    C +G  C    
Sbjct: 1095 VDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGS 1154

Query: 1018 TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRT 1077
              A C C  G +G+ C + +LPC              C  GG C        C+C    +
Sbjct: 1155 PAANCSCLEGLAGQRCQVPTLPCE----------ANPCLNGGTCRAAGGVSECICNARFS 1204

Query: 1078 GSHCE 1082
            G  CE
Sbjct: 1205 GQFCE 1209



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 51/157 (32%), Positives = 62/157 (39%), Gaps = 7/157 (4%)

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
            C   PC H G CR     + C C PG+ G  CE  VD C S PC  G        R+ C 
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119

Query: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADIN 1207
            CPPG  G  C +      P         CL    C        C+C  G  G RC+    
Sbjct: 1120 CPPGFGGPRCRLPV----PSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTL 1175

Query: 1208 ECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244
             C +  C    T    +  GG   C+C+A FSG  C+
Sbjct: 1176 PCEANPCLNGGT---CRAAGGVSECICNARFSGQFCE 1209



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 51/153 (33%), Positives = 65/153 (42%), Gaps = 4/153 (2%)

Query: 201  CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNC 260
            CAPSPC + G CR   D  + CAC PG+EG  CE +VD C    C  G         + C
Sbjct: 1060 CAPSPCLHDGACRDLFD-AFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFEC 1118

Query: 261  QCPPEWTGQFCTEDVD--ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDC 318
            +CPP + G  C   V   EC L    C +G  C       +C C+ G  G+ C      C
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVT-CLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177

Query: 319  ATAVCFHGATCHDRVASFYCACPMGKTGLLCHL 351
                C +G TC        C C    +G  C +
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 160/658 (24%), Positives = 204/658 (31%), Gaps = 157/658 (23%)

Query: 928  CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAH------ 981
            C P  C +GG+CVD    F C C   + G  C   AD   +     GG  S+A       
Sbjct: 609  CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC---ADEIPAATFGLGGAPSSASFLLQEL 665

Query: 982  PGFRCTC------------LESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPG-W 1028
            PG   T             L  F       L  + S    +   R    G+  +  PG W
Sbjct: 666  PGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLS----EGRIRAEVPGSPAVVLPGRW 721

Query: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV--D 1086
               L  +  L       Q    L Q    GG+ +  DS      P G     C Q++  D
Sbjct: 722  DDGLRHLVMLSFGPDQLQ---DLGQHVHVGGRLLAADSQ-----PWGGPFRGCLQDLRLD 773

Query: 1087 PC-----------LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGG 1135
             C            +QP + GG     +               C  + D C+  PC +GG
Sbjct: 774  GCHLPFFPLPLDNSSQPSELGGRQSWNLTA------------GCVSE-DMCSPDPCFNGG 820

Query: 1136 SCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC-- 1193
            +C+     + C+CP    G  C   +    PG P      CL   TC ++  GF C    
Sbjct: 821  TCLVTWNDFHCTCPANFTGPTCA--QQLWCPGQP------CLPPATCEEVPDGFVCVAEA 872

Query: 1194 ------PPGYTGLRCEADINECRSGACHAAHTRDC----LQDPGGGFRCLCHAGFSGPRC 1243
                  P  ++G    A       G   A  TRD     L+   G    +  A  +G   
Sbjct: 873  TFREGPPAAFSGHN--ASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLA 930

Query: 1244 QTVLSPCESQPCQHG--GQCRPSPGP--GGGLTFTCHCAQPFWGPRCER----------- 1288
              V          HG  G   P PGP    G       A         R           
Sbjct: 931  GGVRGG-------HGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATP 983

Query: 1289 -----VARSCRELQCPVGVPCQQTPRGPRCACPPGLSG---PSCRSFPGSPPGASN---- 1336
                 +A     LQ P  V          C     L G   P  R  PG+ PGA      
Sbjct: 984  VALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRPGAAPGAREHFAS 1043

Query: 1337 --------------ASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVS 1382
                            CA +PCLH G+CR   L   F CAC  GW GPRCEA     +  
Sbjct: 1044 WPGTPAPILGCRGAPVCAPSPCLHDGACRD--LFDAFACACGPGWEGPRCEAHV---DPC 1098

Query: 1383 EEPRCPRAACQAK---RGDQRCDRECNSPGCGW--DGGDCSLSV----------GDPWRQ 1427
                C R  C      R + RC      P C       +CSL+V          G P   
Sbjct: 1099 HSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAAN 1158

Query: 1428 CEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCD 1485
            C  L+             C  P    +   C  GG  R    V E  C   F+   C+
Sbjct: 1159 CSCLE-------GLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 50/153 (32%), Positives = 63/153 (41%), Gaps = 10/153 (6%)

Query: 282  PNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV-ASFYCAC 340
            P+ C + G C +     +C C  GW G  C  ++D C +A C  G  CH      F C C
Sbjct: 1062 PSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFECRC 1120

Query: 341  PMGKTGLLCHLDDACVSNPCHEDAIC-DTNPVNG---RAICTCPPGFTGGACDQDVDECS 396
            P G  G  C L     S  C  +  C D +P  G    A C+C  G  G  C      C 
Sbjct: 1121 PPGFGGPRCRL--PVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
              ANPC + G C    G   C C   ++G  CE
Sbjct: 1179 --ANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 45/154 (29%), Positives = 61/154 (39%), Gaps = 8/154 (5%)

Query: 240  CPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
            C    CL+ G C D  + + C C P W G  C   VD C   P  C  G    +  G   
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP--CARGRCHTHPDGRFE 1117

Query: 300  CVCVNGWTGESCSQNI--DDCATAV-CFHGATCHDRVASFYCACPMGKTGLLCHLDD-AC 355
            C C  G+ G  C   +   +C+  V C  G+ C     +  C+C  G  G  C +    C
Sbjct: 1118 CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177

Query: 356  VSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD 389
             +NPC     C      G + C C   F+G  C+
Sbjct: 1178 EANPCLNGGTC--RAAGGVSECICNARFSGQFCE 1209



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 46/146 (31%), Positives = 62/146 (42%), Gaps = 19/146 (13%)

Query: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGP--RCETDVNECLSG--------PCRNQAT 445
           S G +  + LG+ V+  G  L    + + GP   C  D+   L G        P  N + 
Sbjct: 732 SFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLR--LDGCHLPFFPLPLDNSSQ 789

Query: 446 CLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
             +  G+ +    AG       V  D C   PC NGG C    N F CTCP+ F+G TC 
Sbjct: 790 PSELGGRQSWNLTAGC------VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCA 843

Query: 506 LDVDECASTPCRNGAKCVDQPDGYEC 531
             +  C   PC   A C + PDG+ C
Sbjct: 844 QQL-WCPGQPCLPPATCEEVPDGFVC 868



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/276 (26%), Positives = 97/276 (35%), Gaps = 40/276 (14%)

Query: 660 ECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCV 719
           +C   PC  GGSCVD    FRC C      P C          P +      AP     +
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI------PAATFGLGGAPSSASFL 661

Query: 720 CEPGWSGPRCSQSLARDACES--------QPCRAG-------GTCSSDGMGFHCTCPPGV 764
            +    GP  + S      ES            AG       G   ++  G      PG 
Sbjct: 662 LQE-LPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGR 720

Query: 765 --QGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGP--RCQQDV--DECA--- 815
              G +  ++    P+  +  G+     G+L + +  Q W GP   C QD+  D C    
Sbjct: 721 WDDGLRHLVMLSFGPDQLQDLGQHVHVGGRL-LAADSQPWGGPFRGCLQDLRLDGCHLPF 779

Query: 816 GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSC 875
            P P       + L G  S     G            C P+PC NGG+C      F C+C
Sbjct: 780 FPLPLDNSSQPSELGGRQSWNLTAGCVSEDM------CSPDPCFNGGTCLVTWNDFHCTC 833

Query: 876 LPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTC 910
              F GP CA+ +  C   PC  P TC +    F C
Sbjct: 834 PANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 59/203 (29%), Positives = 68/203 (33%), Gaps = 32/203 (15%)

Query: 1262 RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSG 1321
            RP   PG    F      P     C R A  C    C     C+       CAC PG  G
Sbjct: 1030 RPGAAPGAREHFASWPGTPAPILGC-RGAPVCAPSPCLHDGACRDLFDAFACACGPGWEG 1088

Query: 1322 PSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEV 1381
            P C         A    C +APC   G C   P    F C C  G+ GPRC  P  + E 
Sbjct: 1089 PRCE--------AHVDPCHSAPCAR-GRCHTHPDGR-FECRCPPGFGGPRCRLPVPSKEC 1138

Query: 1382 SEEPRC----------PRAACQAKRG--DQRCD---RECNSPGCGWDGGDCSLSVGDPWR 1426
            S    C          P A C    G   QRC      C +  C  +GG C  + G    
Sbjct: 1139 SLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPC-LNGGTCRAAGGVSEC 1197

Query: 1427 QCEALQCWRLFNNSRCDPACSSP 1449
             C A      F+   C+ A   P
Sbjct: 1198 ICNA-----RFSGQFCEVAKGLP 1215



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 23/52 (44%), Positives = 28/52 (53%), Gaps = 1/52 (1%)

Query: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD 217
           +PC +GGTCL T   F C CPA +TGP C    + C   PC    TC +  D
Sbjct: 814 DPCFNGGTCLVTWNDFHCTCPANFTGPTCAQ-QLWCPGQPCLPPATCEEVPD 864



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 75/289 (25%), Positives = 93/289 (32%), Gaps = 85/289 (29%)

Query: 76  CQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS----------------- 118
           C+  + C   PC   G C    V     F C C R  RGP C+                 
Sbjct: 603 CERREQCRPLPCVHGGSC----VDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSA 658

Query: 119 ------LPDPCLSSPCAHGARCSVG-----------------PDGRFLCSCP-------P 148
                 LP P L+       R S G                  +GR     P       P
Sbjct: 659 SFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLP 718

Query: 149 GYQGRSCRSDV------DECR-VGEPCRHGGTCLNTP-----GSFRCQCPAGYTGPLCEN 196
           G      R  V      D+ + +G+    GG  L        G FR  C        C  
Sbjct: 719 GRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFR-GCLQDLRLDGCHL 777

Query: 197 PAVPC----APSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCV 252
           P  P     +  P   GG  RQS +LT  C            V+ D C    C NGGTC+
Sbjct: 778 PFFPLPLDNSSQPSELGG--RQSWNLTAGC------------VSEDMCSPDPCFNGGTCL 823

Query: 253 DGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCV 301
              N ++C CP  +TG  C + +  C  QP  C    TC     G  CV
Sbjct: 824 VTWNDFHCTCPANFTGPTCAQQL-WCPGQP--CLPPATCEEVPDGFVCV 869



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 9/75 (12%)

Query: 435 CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT 494
           C   PC N  TCL     F C C A FTG  C   +  C   PC+    C++  +GF C 
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869

Query: 495 C--------PSGFSG 501
                    P+ FSG
Sbjct: 870 AEATFREGPPAAFSG 884



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 547 DDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
           D CSPDPC +G  C+     F C C   +TG  C  Q+  C  QPC     C ++ D ++
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867

Query: 606 C 606
           C
Sbjct: 868 C 868



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 38/131 (29%), Positives = 48/131 (36%), Gaps = 28/131 (21%)

Query: 724 WSGP--RCSQSLARDACE-----------SQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE 770
           W GP   C Q L  D C            SQP   GG  S     ++ T         C 
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQS-----WNLTAG-------CV 806

Query: 771 LLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLA 830
               C+P+PC +GG C         C+CP  + GP C Q +  C G  PC P   C  + 
Sbjct: 807 SEDMCSPDPCFNGGTCLVTWNDFH-CTCPANFTGPTCAQQL-WCPG-QPCLPPATCEEVP 863

Query: 831 GSFSCTCHGGY 841
             F C     +
Sbjct: 864 DGFVCVAEATF 874



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 70/288 (24%), Positives = 89/288 (30%), Gaps = 61/288 (21%)

Query: 117 CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG---EPCRHGGT 173
           C   + C   PC HG  C V     F C C   ++G +C  ++     G    P      
Sbjct: 603 CERREQCRPLPCVHGGSC-VDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFL 661

Query: 174 CLNTPG-------------------SFRCQCPAGYTGPLCEN------PAVPCAPSPCRN 208
               PG                    F     AG T  L E       P  P    P R 
Sbjct: 662 LQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRW 721

Query: 209 GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
               R    L++    L    GQ+  V      G R L   +               W G
Sbjct: 722 DDGLRHLVMLSFGPDQLQDL-GQHVHV------GGRLLAADS-------------QPWGG 761

Query: 269 QF--CTEDV--DECQLQ--PNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV 322
            F  C +D+  D C L   P    N     + LGG        W   +   + D C+   
Sbjct: 762 PFRGCLQDLRLDGCHLPFFPLPLDNSSQP-SELGGRQ-----SWNLTAGCVSEDMCSPDP 815

Query: 323 CFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNP 370
           CF+G TC      F+C CP   TG  C     C   PC   A C+  P
Sbjct: 816 CFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVP 863



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 2/62 (3%)

Query: 661 CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCV 719
           C+  PC  GG+C+   N F C CP     P C      C  +PC     C + P GF CV
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW-CPGQPCLPPATCEEVPDGFVCV 869

Query: 720 CE 721
            E
Sbjct: 870 AE 871



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 27/78 (34%), Positives = 36/78 (46%), Gaps = 5/78 (6%)

Query: 384 TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ 443
           T G   +D+  CS   +PC + G C+ T   F C C   +TGP C   +  C   PC   
Sbjct: 802 TAGCVSEDM--CS--PDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPP 856

Query: 444 ATCLDRIGQFTCICMAGF 461
           ATC +    F C+  A F
Sbjct: 857 ATCEEVPDGFVCVAEATF 874



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 2/65 (3%)

Query: 619 VNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGEN 677
           V+ D C+ +PC   G C    N + C C   FTGP C  ++  C   PC    +C +  +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPD 864

Query: 678 GFRCL 682
           GF C+
Sbjct: 865 GFVCV 869



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 75/292 (25%), Positives = 96/292 (32%), Gaps = 40/292 (13%)

Query: 699 CAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM--- 754
           C   PC HG  C D    FRC C     GP C+     D   +     GG  SS      
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA-----DEIPAATFGLGGAPSSASFLLQ 663

Query: 755 ---GFHCTCPPGVQGRQCELLSPCTPNPCEHG-------GRCESAPGQLPVCSCPQGWQG 804
              G + T    ++ R+   L     N    G       GR  +     P    P  W  
Sbjct: 664 ELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDD 723

Query: 805 PRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGP--SCDQDI--NDCD----PN 856
              +  V    GP      G   ++ G         + GP   C QD+  + C     P 
Sbjct: 724 G-LRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPL 782

Query: 857 PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPG 915
           P  N     +  G  S +   G     C  + D C  +PC   GTC      F CTCP  
Sbjct: 783 PLDNSSQPSELGGRQSWNLTAG-----CVSE-DMCSPDPCFNGGTCLVTWNDFHCTCPAN 836

Query: 916 YGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLC----RPGYTGAHCQHEA 963
           + G  C Q L  C    C    TC +  + F C+     R G   A   H A
Sbjct: 837 FTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNA 887



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 23/73 (31%), Positives = 31/73 (42%), Gaps = 3/73 (4%)

Query: 117 CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLN 176
           C   D C   PC +G  C V  +  F C+CP  + G +C   +     G+PC    TC  
Sbjct: 805 CVSEDMCSPDPCFNGGTCLVTWND-FHCTCPANFTGPTCAQQL--WCPGQPCLPPATCEE 861

Query: 177 TPGSFRCQCPAGY 189
            P  F C   A +
Sbjct: 862 VPDGFVCVAEATF 874



 Score = 41.6 bits (96), Expect = 0.009
 Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 579 CESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDG 637
           C S+ D C   PC +GG CL   + + C CP+  TG  C   +  C   PC     C + 
Sbjct: 805 CVSE-DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEV 862

Query: 638 INRYDCVCQPGF 649
            + + CV +  F
Sbjct: 863 PDGFVCVAEATF 874



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 14/34 (41%), Positives = 18/34 (52%)

Query: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLC 1157
            ++C   PC HGGSC+DL   + C C     G  C
Sbjct: 607  EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)

Query: 1081 CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV 1123
            CE+  + C   PC HGG+C      + C+C   + G  C D++
Sbjct: 603  CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 14/34 (41%), Positives = 16/34 (47%)

Query: 964 DPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQC 997
           + C   PC+HGG C      FRC C     GP C
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 20/66 (30%), Positives = 25/66 (37%), Gaps = 4/66 (6%)

Query: 769 CELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECA---GPAPCGPHGI 825
           CE    C P PC HGG C         C C +  +GP C  ++       G AP     +
Sbjct: 603 CERREQCRPLPCVHGGSCVDLWTHFR-CDCARPHRGPTCADEIPAATFGLGGAPSSASFL 661

Query: 826 CTNLAG 831
              L G
Sbjct: 662 LQELPG 667



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 8/50 (16%)

Query: 1157 CEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADI 1206
            CE  E  C P P       C+H G+CVDL   FRC C   + G  C  +I
Sbjct: 603  CERREQ-CRPLP-------CVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 23/86 (26%), Positives = 30/86 (34%), Gaps = 5/86 (5%)

Query: 37  GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQ-- 94
           G  +       PC NGG C  +   +  C CP  + G  C  +  C   PC     C+  
Sbjct: 804 GCVSEDMCSPDPCFNGGTCL-VTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEV 862

Query: 95  --SSVVAGTARFSCRCPRGFRGPDCS 118
               V    A F    P  F G + S
Sbjct: 863 PDGFVCVAEATFREGPPAAFSGHNAS 888



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 1/46 (2%)

Query: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC 554
           D C+  PC NG  C+   + + C C   F G  C + +  C   PC
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPC 853



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 20/69 (28%), Positives = 25/69 (36%), Gaps = 5/69 (7%)

Query: 349 CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRC 408
           C  +D C  +PC     C     +    CTCP  FTG  C Q   +      PC     C
Sbjct: 805 CVSEDMCSPDPCFNGGTCLVTWNDFH--CTCPANFTGPTCAQ---QLWCPGQPCLPPATC 859

Query: 409 VNTQGSFLC 417
                 F+C
Sbjct: 860 EEVPDGFVC 868



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 30/109 (27%), Positives = 43/109 (39%), Gaps = 22/109 (20%)

Query: 185 CPAGY---TGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL-----------PGFEG 230
           CPA     +GP+         P P   G +  Q GD T+   CL           P   G
Sbjct: 540 CPARLCVASGPVALASTASATPLPA--GISSAQLGDATF-AGCLQDVRVDGHLLLPEDLG 596

Query: 231 QN----CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV 275
           +N    CE   + C    C++GG+CVD    + C C     G  C +++
Sbjct: 597 ENVLLGCERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 16/38 (42%), Positives = 18/38 (47%), Gaps = 6/38 (15%)

Query: 1255 CQHGGQCRPSPGPGGGLT------FTCHCAQPFWGPRC 1286
            C+   QCRP P   GG        F C CA+P  GP C
Sbjct: 603  CERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  305 bits (782), Expect = 3e-82
 Identities = 307/1021 (30%), Positives = 395/1021 (38%), Gaps = 227/1021 (22%)

Query: 2    GPG----ARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQ 57
            GPG    A   R   RP+   PP   +     L   + P A   P     P     R   
Sbjct: 395  GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP-RPDP 453

Query: 58   LPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
             P  E      P W G          SGP +G  +CQ                  R P  
Sbjct: 454  RPGPELPLPSIPAWTGPEIP-----ESGPSSG--MCQ------------------RNPQV 488

Query: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGT 173
              P  C+S P              + C+C  G+    QG  C  DVDECR   P    G 
Sbjct: 489  CGPGRCISRPSG------------YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR 535

Query: 174  CLNTPGSFRCQCPAGY-TGPLCENPAVPC--------APSPCRNGGTCRQSGDLTYDCAC 224
            C N+PGSFRC C  G+  GP     A  C         P PC  G      G  ++ C C
Sbjct: 536  CENSPGSFRCVCGPGFRAGP----RAAECLDVDECHRVPPPCDLGRCENTPG--SFLCVC 589

Query: 225  LPGFE----GQNCEVNVDDCPGHRCLNG-GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQ 279
              G++    G +C+ +VD+C     L G G C +   ++ C CP  + G  C EDVDEC 
Sbjct: 590  PAGYQAAPHGASCQ-DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECA 648

Query: 280  LQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCSQNIDDCATA--VCFHGATCHDRV 333
             +P  C   G C NT G   C C  G+     G  C Q++D+CA +   C +G  C +  
Sbjct: 649  QEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYG-RCENTE 705

Query: 334  ASFYCACPMG----KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC-TCPPG--FTGG 386
             SF C CPMG      G  C   D C ++       C  +P  G   C TCP G     G
Sbjct: 706  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP--GSFQCRTCPSGHHLHRG 763

Query: 387  ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE----TDVNECLSGP-CR 441
             C  DVDECS GA PC   G C NT+GSF C C  GY  P        DVNECL G  C 
Sbjct: 764  RC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 822

Query: 442  NQATCLDRIGQFTCICMAGF----TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497
                CL+  G F C C  G+     G  C +D+DEC        G+C +    F C CP 
Sbjct: 823  PHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPP 881

Query: 498  GFSG----STCQLDVDECAST-PCRNGA-KCVDQPDGYEC--RCAEGF----EGTLCDRN 545
            G       ++C LDVDEC    P   G+ +C + P  Y C   C  G+    EGT CD +
Sbjct: 882  GHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CD-D 938

Query: 546  VDDC---SPDPCHHGRCVDGIASFSC--ACAPGY---TGTRCESQVDECRSQP-CRHGGK 596
            VD+C    P+ C   RC +   S+ C  AC PGY    G  C+  VDECR++  C     
Sbjct: 939  VDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECRNRSFCGAHAV 997

Query: 597  CLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNV 656
            C +L   + C C  G  G                    RDG +   C            V
Sbjct: 998  CQNLPGSFQCLCDQGYEG-------------------ARDGRH---C------------V 1023

Query: 657  EINECAS--SPCGEGGSCVDGENGFRCLCP--PGSLPPL---CLPPSHPCAHEPCSHGIC 709
            ++NEC +    CG    C + E  F C+CP  P    P+   C+PP       P S    
Sbjct: 1024 DVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQA 1082

Query: 710  YDAP-----------------------GGFRCVCEPGWSGP-RCSQSLARDACESQPCRA 745
              +P                       G  R  C    + P  C   LAR+    + C  
Sbjct: 1083 PASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCT 1142

Query: 746  GGTCSSDGMGFHCTCP--PGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803
             G    +G G  C     PG +  + + L       C HG    +  G L +        
Sbjct: 1143 VG----EGWGSGCRIQQCPGTETAEYQSL-------CPHGRGYLAPSGDLSL-------- 1183

Query: 804  GPRCQQDVDECA--GPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNP 857
                ++DVDEC       C   G+C N A  +SC C  GY        C  +    D  P
Sbjct: 1184 ----RRDVDECQLFRDQVC-KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEP 1238

Query: 858  CLNGGSCQDGVGSFSCSCLPGF----AGPRCARDVDECLSNPCGPGTCTDHV-ASFTCTC 912
               GG C + VGS+ C+C P      +  RC  +  + L +    G C   V A   C+ 
Sbjct: 1239 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD--NLGVCWQEVGADLVCSH 1296

Query: 913  P 913
            P
Sbjct: 1297 P 1297



 Score =  300 bits (769), Expect = 8e-81
 Identities = 388/1371 (28%), Positives = 501/1371 (36%), Gaps = 341/1371 (24%)

Query: 249  GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-- 306
            G C  G    N  C          EDVDEC       H  G C NT GG++CVC +G+  
Sbjct: 275  GPCPTGFERVNGSC----------EDVDECATGGRCQH--GECANTRGGYTCVCPDGFLL 322

Query: 307  --TGESC-SQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHED 363
              +  SC SQ++   A   CF      D   S      + K    C          C   
Sbjct: 323  DSSRSSCISQHVISEAKGPCFR--VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ-- 378

Query: 364  AICDTNPVNG-RAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR- 421
             +C      G R IC   PG+   A D   +   +G  P     R   +Q   L    R 
Sbjct: 379  -LCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEP----PRVSLSQPRTLPATSRP 433

Query: 422  --------------------------------GYTGPRCETDVNECLSGPCRNQ------ 443
                                             +TGP  E   +   SG C+        
Sbjct: 434  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGP--EIPESGPSSGMCQRNPQVCGP 491

Query: 444  ATCLDRIGQFTCICMAGF----TGTYCEVDIDECQ--SSPCVNGGVCKDRVNGFSCTCPS 497
              C+ R   +TC C +GF     GT C +D+DEC+    PC  G  C++    F C C  
Sbjct: 492  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR-CENSPGSFRCVCGP 549

Query: 498  GF----SGSTCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFE----GTLCDRNVD 547
            GF      + C LDVDEC     PC  G +C + P  + C C  G++    G  C ++VD
Sbjct: 550  GFRAGPRAAEC-LDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASC-QDVD 606

Query: 548  DC--SPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHG-GKCLDLVDKY 604
            +C  SP  C  G C +   SF C C  G+ G+ CE  VDEC  +P   G G+C +    +
Sbjct: 607  ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF 666

Query: 605  LCRCPSG----TTGVNCEVNIDDCASN--PCTFGVCRDGINRYDCVC----QPGFTGPLC 654
             C CP+G      G  C+ ++D+CA +  PCT+G C +    + CVC    QP   G  C
Sbjct: 667  HCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 725

Query: 655  N---------------------------------------VEINECASS--PCGEGGSCV 673
                                                     +++EC+S   PCG  G C 
Sbjct: 726  EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT 785

Query: 674  DGENGFRCLCPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGW- 724
            + E  FRC C PG   P   P   PCA    C        HG C +  G F C C PG+ 
Sbjct: 786  NTEGSFRCSCAPGYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR 843

Query: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGG 784
             GPR +  L  D C  +     G C++    F C CPPG +    +L S    + C   G
Sbjct: 844  PGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP-DLASCLDVDECRERG 902

Query: 785  -------RCESAPGQLP-VCSCPQGWQ-GPR-CQQDVDECA--GPAPCGPHGICTNLAGS 832
                   RCE++PG    V  C  G+  GP     DVDEC   GP  CG    C N  GS
Sbjct: 903  PALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-CENTPGS 961

Query: 833  FSCT--CHGGY---TGPSCDQDINDC-DPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
            + CT  C  GY    G  C QD+++C + + C     CQ+  GSF C C  G+ G R  R
Sbjct: 962  YRCTPACDPGYQPTPGGGC-QDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGR 1020

Query: 887  ---DVDEC--LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVD 941
               DV+EC  L   CG   C +   SF C CP     F          P +    G CV 
Sbjct: 1021 HCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEF---------DPMT----GRCVP 1067

Query: 942  GVNSFSCLCRPGYTGAHCQHEADPCL-SRPCLHGGVCSAAHPGFRCTCLESFTGP-QCQT 999
               S        + G+  Q  A P L +RP           P    T  +   G  + + 
Sbjct: 1068 PRTSAGT-----FPGSQPQAPASPVLPARP------PPPPLPRRPSTPRQGPVGSGRREC 1116

Query: 1000 LVDWCSRQPCQNGGRCVQTGAYCLCP--PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
              D  +   C N      T   C C    GW G  C I+  P  E A       + LC  
Sbjct: 1117 YFDTAAPDACDNILARNVTWQECCCTVGEGW-GSGCRIQQCPGTETA-----EYQSLCPH 1170

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA---QPCQHGGTCRGYMGGYMCECLPGY 1114
            G            + P G       ++VD C     Q C+  G C     GY C C  GY
Sbjct: 1171 G---------RGYLAPSGDLS--LRRDVDECQLFRDQVCK-SGVCVNTAPGYSCYCSNGY 1218

Query: 1115 ----NGDNCEDDVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPP 1169
                    C D+ DECA  +P   GG C++ V  Y C+C P  +                
Sbjct: 1219 YYHTQRLECIDN-DECADEEPACEGGRCVNTVGSYHCTCEPPLV---------------- 1261

Query: 1170 LD-SGPRCLHN---------GTCVDLVGG-FRCTCPPGYTGLRCEADINECRSGACHAAH 1218
            LD S  RC+ N         G C   VG    C+ P     L  +A   EC    C    
Sbjct: 1262 LDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHP----RLDRQATYTEC----C---- 1309

Query: 1219 TRDCLQDPGGGFRC-LCHAGFSG---PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFT 1274
               CL     G  C LC A  S      C  +  P  S P       RP    G GL + 
Sbjct: 1310 ---CLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPP-------RPG---GFGLPYE 1356

Query: 1275 CHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGA 1334
                   +GP               +G P Q  P GP    PP L        P  PP  
Sbjct: 1357 -------YGP--------------DLGPPYQGLPYGPELYPPPALPYD-----PYPPPPG 1390

Query: 1335 SNASCAAAPCLHGGSCRPAPL-APFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQ 1393
              A             R AP  AP F     +   GP  E+ A AP      R P     
Sbjct: 1391 PFAR------------REAPYGAPRFDMPDFEDDGGPYGESEAPAPP-GPGTRWP----Y 1433

Query: 1394 AKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL--FNNSRC 1442
              R  +R   E   P    +GG  + S+ +P+ + EA +C  L    N RC
Sbjct: 1434 RSRDTRRSFPEPEEPP---EGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1481



 Score =  268 bits (685), Expect = 5e-71
 Identities = 292/1031 (28%), Positives = 390/1031 (37%), Gaps = 181/1031 (17%)

Query: 43   CLDGSPCANGGRCTQLPSREA----ACLCPPGWVGERCQLEDPCHS--------GPC--- 87
            C D   CA GGRC             C+CP G++ +  +    C S        GPC   
Sbjct: 288  CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSR--SSCISQHVISEAKGPCFRV 345

Query: 88   AGRGVCQSSVVAGTARFSCRCPRGFR--GPDCSLPDPCLSSPCAHGAR--CSVGPDGRFL 143
               G C   ++    +  C C R  +  G  C L  P  S     G R  C  GP   + 
Sbjct: 346  LRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSE----GFREICPAGPGYHYS 401

Query: 144  CSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE-------N 196
             S    Y  R    +     + +P     T   + G      P     P  E        
Sbjct: 402  AS-DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFL----PTHRLEPRPEPRPDPRPG 456

Query: 197  PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 256
            P +P    P   G    +SG                C+ N   C        G C+   +
Sbjct: 457  PELPLPSIPAWTGPEIPESGP-----------SSGMCQRNPQVC------GPGRCISRPS 499

Query: 257  TYNCQCPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-TGESC 311
             Y C C   +     G  C  DVDEC+  P  C  G  C N+ G   CVC  G+  G   
Sbjct: 500  GYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRA 557

Query: 312  SQ--NIDDC--ATAVCFHGATCHDRVASFYCACPMGKT----GLLCHLDDACVSNP--CH 361
            ++  ++D+C      C  G  C +   SF C CP G      G  C   D C  +P  C 
Sbjct: 558  AECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 616

Query: 362  EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR 421
              A C   P + R  C CP GF G AC++DVDEC+    PC   GRC NT GSF C C  
Sbjct: 617  RGA-CKNLPGSFR--CVCPAGFRGSACEEDVDECAQEPPPCGP-GRCDNTAGSFHCACPA 672

Query: 422  GYT----GPRCETDVNECL-SGPCRNQATCLDRIGQFTCICMAGF----TGTYCEVDIDE 472
            G+     G  C+ DV+EC  S P      C +  G F C+C  GF     G+ CE D+DE
Sbjct: 673  GFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDE 730

Query: 473  CQSSPCVNGGVCKDRVNGFSC-TCPSG--FSGSTCQLDVDECAS--TPCRNGAKCVDQPD 527
            C++     G  C +    F C TCPSG       C  DVDEC+S   PC     C +   
Sbjct: 731  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEG 789

Query: 528  GYECRCAEGFE------GTLCDRNV----DDCSPDPCHHGRCVDGIASFSCACAPGYT-- 575
             + C CA G+       G   D N     D C P    HG C++   SF+C CAPGY   
Sbjct: 790  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFP----HGECLNTDGSFACTCAPGYRPG 845

Query: 576  --GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG----VNCEVNIDDCASNP- 628
              G  C   VDEC  +     G C +    + C CP G        +C +++D+C     
Sbjct: 846  PRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGP 903

Query: 629  --CTFGVCRDGINRYDCV--CQPGF-TGP--LCNVEINECAS---SPCGEGGSCVDGENG 678
              C    C +    Y CV  C PG+  GP   C+ +++EC       CG    C +    
Sbjct: 904  ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICG-AQRCENTPGS 961

Query: 679  FRCL--CPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGWSGPR 728
            +RC   C PG  P     P   C   + C       +H +C + PG F+C+C+ G+ G R
Sbjct: 962  YRCTPACDPGYQPT----PGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR 1017

Query: 729  CSQSLAR-DACES-QPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG--- 783
              +     + CE+ Q       C +    F C CP   +     +   C P     G   
Sbjct: 1018 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD-PMTGRCVPPRTSAGTFP 1076

Query: 784  GRCESAPGQ--LPVCSCP-----------QGWQGPRCQQDVDECAGPAPCGPHGICTNLA 830
            G    AP    LP    P           QG  G   ++   + A P  C  + +  N+ 
Sbjct: 1077 GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACD-NILARNVT 1135

Query: 831  GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGS-CQDGVGSFSCSCLPGFAGPRCARDVD 889
                C   G   G  C   I  C         S C  G G  + S           RDVD
Sbjct: 1136 WQECCCTVGEGWGSGCR--IQQCPGTETAEYQSLCPHGRGYLAPS-----GDLSLRRDVD 1188

Query: 890  ECL---SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ----DLPDCSPSS-CFNGGTCVD 941
            EC       C  G C +    ++C C  GY  +H ++    D  +C+       GG CV+
Sbjct: 1189 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEGGRCVN 1247

Query: 942  GVNSFSCLCRP 952
             V S+ C C P
Sbjct: 1248 TVGSYHCTCEP 1258



 Score =  263 bits (673), Expect = 1e-69
 Identities = 268/901 (29%), Positives = 367/901 (40%), Gaps = 194/901 (21%)

Query: 474  QSSPCVNG-------GVCKDRVNGFSCTCPSG--------FSGSTCQLDVDECASTPCRN 518
            QS+P  +G       G C   + G  C  P            G+     V +C     R 
Sbjct: 205  QSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERL 264

Query: 519  G-AKCVDQPDGYECRCAEGFEGT--LCDRNVDDCSPDP-CHHGRCVDGIASFSCACAPGY 574
            G ++ V  PDG    C  GFE     C+ +VD+C+    C HG C +    ++C C  G+
Sbjct: 265  GNSERVSAPDG---PCPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGF 320

Query: 575  ----TGTRCESQ--VDECRSQPC----RHGGKCLDL---VDKYLCRCP--SGTTGVNCEV 619
                + + C SQ  + E +  PC    R GG  L +   + K +C C       G  C++
Sbjct: 321  LLDSSRSSCISQHVISEAKG-PCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQL 379

Query: 620  NIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 679
                C      FG   +G  R  C   PG+     ++  N   + P G+    V      
Sbjct: 380  ----CP----PFG--SEGF-REICPAGPGYHYSASDLRYN---TRPLGQEPPRVS----- 420

Query: 680  RCLCPPGSLPPLCLP----------------------------PSHP------------- 698
              L  P +LP    P                            PS P             
Sbjct: 421  --LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPS 478

Query: 699  ---CAHEP--CSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARDACE--SQPCRAGGTCS 750
               C   P  C  G C   P G+ C C+ G+   P+ ++ +  D C     PC A G C 
Sbjct: 479  SGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCE 537

Query: 751  SDGMGFHCTCPPGV----QGRQCELLSPC--TPNPCEHGGRCESAPGQLPVCSCPQGWQ- 803
            +    F C C PG     +  +C  +  C   P PC+  GRCE+ PG   +C CP G+Q 
Sbjct: 538  NSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPGSF-LCVCPAGYQA 595

Query: 804  ---GPRCQQDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC--DPNP 857
               G  C QDVDEC   P  CG  G C NL GSF C C  G+ G +C++D+++C  +P P
Sbjct: 596  APHGASC-QDVDECTQSPGLCG-RGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPP 653

Query: 858  CLNGGSCQDGVGSFSCSCLPGF--AGPRC-ARDVDECLSN--PCGPGTCTDHVASFTCTC 912
            C   G C +  GSF C+C  GF   GP    +DVDEC  +  PC  G C +   SF C C
Sbjct: 654  C-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVC 712

Query: 913  PPGY----GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQH----EAD 964
            P G+     G  CE D+ +C       G  CV+   SF C   P  +G H       + D
Sbjct: 713  PMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCP--SGHHLHRGRCTDVD 769

Query: 965  PCLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQ-----CQTLVDWCSRQPCQNGGRCVQ 1017
             C S   PC   G C+     FRC+C   +  P      C  + +      C   G C+ 
Sbjct: 770  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLN 829

Query: 1018 T-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG 1075
            T G++ C C PG+         L   E +       E LCQ+ G C + D S  C+CP G
Sbjct: 830  TDGSFACTCAPGYRPGPRGASCLDVDECSE------EDLCQS-GICTNTDGSFECICPPG 882

Query: 1076 -RTGSHCEQ--EVDPCLAQ-PCQHGG-TCRGYMGGYMC--ECLPGYNG--DNCEDDVDEC 1126
             R G       +VD C  + P   G   C    G Y C  +C PGY+   +   DDVDEC
Sbjct: 883  HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDEC 942

Query: 1127 ASQPCQHGGS--CIDLVARYLC--SCPPG---TLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
                 +  G+  C +    Y C  +C PG   T G  C+ + D+C       +   C  +
Sbjct: 943  QEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDEC------RNRSFCGAH 995

Query: 1180 GTCVDLVGGFRCTCPPGYTGLR----CEADINECRS--GACHAAHTRDCLQDPGGGFRCL 1233
              C +L G F+C C  GY G R    C  D+NEC +  G C AA      ++  G F C+
Sbjct: 996  AVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCGAA----LCENVEGSFLCV 1050

Query: 1234 C 1234
            C
Sbjct: 1051 C 1051



 Score =  263 bits (671), Expect = 2e-69
 Identities = 325/1112 (29%), Positives = 436/1112 (39%), Gaps = 223/1112 (20%)

Query: 486  DRVNGFSCTCPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGFEGTLC 542
            +RV+     CP+GF     +C+ DVDECA+   C++G +C +   GY C C +GF   L 
Sbjct: 268  ERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF---LL 322

Query: 543  DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPC----RHGGKCL 598
            D +   C             I+    + A G                PC    R GG  L
Sbjct: 323  DSSRSSC-------------ISQHVISEAKG----------------PCFRVLRDGGCSL 353

Query: 599  DL---VDKYLCRCP--SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPL 653
             +   + K +C C       G  C++    C      FG   +G  R  C   PG+    
Sbjct: 354  PILRNITKQICCCSRVGKAWGRGCQL----CP----PFG--SEGF-REICPAGPGYHYSA 402

Query: 654  CNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP-----PSHPCAHEPCSHGI 708
             ++  N   + P G+    V        L  P +LP    P     P+H     P     
Sbjct: 403  SDLRYN---TRPLGQEPPRVS-------LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 452

Query: 709  CYDAPGGFRCVCEPGWSGPRCSQS-LARDACESQPCRAG-GTCSSDGMGFHCTCPPGV-- 764
                P        P W+GP   +S  +   C+  P   G G C S   G+ C C  G   
Sbjct: 453  PRPGP-ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 511

Query: 765  --QGRQCELLSPC--TPNPCEHGGRCESAPGQLPVCSCPQGWQ-GPRCQQ--DVDECAGP 817
              QG +C  +  C   P PC   GRCE++PG    C C  G++ GPR  +  DVDEC   
Sbjct: 512  SPQGTRCIDVDECRRVPPPCA-PGRCENSPGSFR-CVCGPGFRAGPRAAECLDVDECHRV 569

Query: 818  APCGPHGICTNLAGSFSCTCHGGYT----GPSCDQDINDCDPNPCLNG-GSCQDGVGSFS 872
             P    G C N  GSF C C  GY     G SC QD+++C  +P L G G+C++  GSF 
Sbjct: 570  PPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQSPGLCGRGACKNLPGSFR 628

Query: 873  CSCLPGFAGPRCARDVDECLSN--PCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLP 926
            C C  GF G  C  DVDEC     PCGPG C +   SF C CP G+     G  C QD+ 
Sbjct: 629  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVD 687

Query: 927  DC--SPSSCFNGGTCVDGVNSFSCLC----RPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
            +C  SP  C   G C +   SF C+C    +P   G+ C+ + D C +     G  C  +
Sbjct: 688  ECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNS 745

Query: 981  HPGFRCTCLES---FTGPQCQTLVDWCS--RQPCQNGGRCVQT-GAY-CLCPPGWSGRLC 1033
               F+C    S       +C T VD CS    PC   G C  T G++ C C PG+  R  
Sbjct: 746  PGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--RAP 802

Query: 1034 DIRSLPCREAAAQIGVRLE-QLCQAGGQCVDEDSSHYCVCP----EGRTGSHCEQEVDPC 1088
              R  PC    A +   LE   C   G+C++ D S  C C      G  G+ C  +VD C
Sbjct: 803  SGRPGPC----ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDEC 857

Query: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGD----NCEDDVDECASQPCQHGGS--CIDLVA 1142
              +     G C    G + C C PG+       +C  DVDEC  +     GS  C +   
Sbjct: 858  SEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCL-DVDECRERGPALCGSQRCENSPG 916

Query: 1143 RYLC--SCPPGTLG---VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT--CPP 1195
             Y C   C PG        C+ + D+C      + GP       C +  G +RCT  C P
Sbjct: 917  SYRCVRDCDPGYHAGPEGTCD-DVDEC-----QEYGPEICGAQRCENTPGSYRCTPACDP 970

Query: 1196 GY---TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            GY    G  C+ D++ECR+ +   AH     Q+  G F+CLC  G+ G R        + 
Sbjct: 971  GYQPTPGGGCQ-DVDECRNRSFCGAHA--VCQNLPGSFQCLCDQGYEGAR--------DG 1019

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
            + C    +C    G  G                CE V  S     CP   P +  P   R
Sbjct: 1020 RHCVDVNECETLQGVCGAAL-------------CENVEGSFL-CVCP-NSPEEFDPMTGR 1064

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGP-- 1370
            C  P   +G    +FPGS P A      A+P L      P P  P       QG  G   
Sbjct: 1065 CVPPRTSAG----TFPGSQPQA-----PASPVLPARP--PPPPLPRRPSTPRQGPVGSGR 1113

Query: 1371 -RCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQC- 1428
              C    AAP+  +               Q C   C + G GW G  C +      +QC 
Sbjct: 1114 RECYFDTAAPDACDNILARNVTW------QEC---CCTVGEGW-GSGCRI------QQCP 1157

Query: 1429 --EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN--------PVYEKYCAD- 1477
              E  +   L  + R   A S    L  + D     R++ C         P Y  YC++ 
Sbjct: 1158 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1217

Query: 1478 ---HFADGRC--DQGCNTEECGWDGLDCASEV 1504
               H     C  +  C  EE   +G  C + V
Sbjct: 1218 YYYHTQRLECIDNDECADEEPACEGGRCVNTV 1249



 Score =  250 bits (639), Expect = 1e-65
 Identities = 310/1099 (28%), Positives = 401/1099 (36%), Gaps = 249/1099 (22%)

Query: 48   PCANGGRCTQLPSREAACLCPPGW-VGER---CQLEDPCHS-GPCAGRGVCQSSVVAGTA 102
            PCA G RC   P     C+C PG+  G R   C   D CH   P    G C+++      
Sbjct: 530  PCAPG-RCENSPG-SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT----PG 583

Query: 103  RFSCRCPRGFR----GPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
             F C CP G++    G  C   D C  SP  C  GA C   P G F C CP G++G +C 
Sbjct: 584  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLP-GSFRCVCPAGFRGSACE 641

Query: 157  SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC--------APSPCRN 208
             DVDEC    P    G C NT GSF C CPAG+       P  PC        +P PC  
Sbjct: 642  EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRS---RGPGAPCQDVDECARSPPPCTY 698

Query: 209  GGTCRQSGDLTYDCACLPGFE----GQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP 264
            G      G  ++ C C  GF+    G  CE +VD+C  H    G  CV+   ++ C+  P
Sbjct: 699  GRCENTEG--SFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCP 755

Query: 265  E----WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGES-----CSQNI 315
                   G+ CT DVDEC      C   G C NT G   C C  G+   S     C+ ++
Sbjct: 756  SGHHLHRGR-CT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA-DV 812

Query: 316  DDCATA-VCFHGATCHDRVASFYCACP----MGKTGLLCHLDDACVSNPCHEDAICDTNP 370
            ++C     CF    C +   SF C C      G  G  C   D C      +  IC TN 
Sbjct: 813  NECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC-TN- 870

Query: 371  VNGRAICTCPPGFTGG---ACDQDVDECSIGANPCEHLGRCVNTQGSFLC--QCGRGY-T 424
             +G   C CPPG   G   A   DVDEC           RC N+ GS+ C   C  GY  
Sbjct: 871  TDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA 930

Query: 425  GPR--CETDVNECLS-GP--CRNQATCLDRIGQFTC--ICMAGF---TGTYCEVDIDECQ 474
            GP   C+ DV+EC   GP  C  Q  C +  G + C   C  G+    G  C+ D+DEC+
Sbjct: 931  GPEGTCD-DVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECR 987

Query: 475  S-SPCVNGGVCKDRVNGFSCTCPSGFSGST----CQLDVDECASTPCRNGAKCVDQPDG- 528
            + S C    VC++    F C C  G+ G+     C +DV+EC +     GA   +  +G 
Sbjct: 988  NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCGAALCENVEGS 1046

Query: 529  YECRC--------------------AEGFEGTLCDRNVDDCSP----------------- 551
            + C C                    A  F G+          P                 
Sbjct: 1047 FLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQ 1106

Query: 552  DPCHHGR---CVDGIASFSC--ACAPGYTGTRCESQVDE-----CRSQPCRHGGKCLDLV 601
             P   GR     D  A  +C    A   T   C   V E     CR Q C          
Sbjct: 1107 GPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETA---- 1162

Query: 602  DKYLCRCPSG------TTGVNCEVNIDDC---ASNPCTFGVCRDGINRYDCVCQPGF--- 649
             +Y   CP G      +  ++   ++D+C       C  GVC +    Y C C  G+   
Sbjct: 1163 -EYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYH 1221

Query: 650  TGPLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPS-HPCAHEPCSH- 706
            T  L  ++ +ECA   P  EGG CV+    + C C     PPL L  S   C        
Sbjct: 1222 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCE----PPLVLDGSQRRCVSNESQSL 1277

Query: 707  ----GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP 762
                G+C+   G    VC    S PR    L R A  ++ C   G    +  G  C   P
Sbjct: 1278 DDNLGVCWQEVGA-DLVC----SHPR----LDRQATYTECCCLYG----EAWGMDCALCP 1324

Query: 763  GVQGRQ----CELLSPCTPNPCEHGG---------------------------------R 785
                      C +L P   +P   GG                                  
Sbjct: 1325 AQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDP 1384

Query: 786  CESAPGQLPVCSCPQG---WQGPRCQQD---VDECAGPAPCGPHGICTNLAGSFSCTCHG 839
                PG       P G   +  P  + D     E   PAP GP                 
Sbjct: 1385 YPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGP----------------- 1427

Query: 840  GYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC-LSNPCGP 898
            G   P   +D     P P        +G GS++ S     A P    + +EC + + C  
Sbjct: 1428 GTRWPYRSRDTRRSFPEP----EEPPEG-GSYAGS----LAEPYEELEAEECGILDGCTN 1478

Query: 899  GTCTDHVASFTCTCPPGY----GGFHC----EQDLPDCSPSSCFNGGTCVDGVNSFSCLC 950
            G C      FTC C  GY        C    E D  + +   C N   C++   SF C+C
Sbjct: 1479 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCIC 1537

Query: 951  RPGYTGAHCQHEADPCLSR 969
            RPG+   H  H   P   R
Sbjct: 1538 RPGFAPTHQPHHCAPARPR 1556



 Score =  240 bits (612), Expect = 1e-62
 Identities = 279/990 (28%), Positives = 370/990 (37%), Gaps = 203/990 (20%)

Query: 570  CAPGYTGTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
            C     G  C S +   R+Q   CR  G    + D  LC   S   G +  V+  D    
Sbjct: 222  CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLC---SERLGNSERVSAPD---- 274

Query: 628  PCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGS 687
                G C  G  R +  C+          +++ECA+    + G C +   G+ C+CP G 
Sbjct: 275  ----GPCPTGFERVNGSCE----------DVDECATGGRCQHGECANTRGGYTCVCPDGF 320

Query: 688  LPPLCLPPSHPCAHEPCSHGICYDAPGG-FRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
            L    L  S        S  +  +A G  FR + + G S P       +  C S+  +A 
Sbjct: 321  L----LDSSRSSC---ISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAW 373

Query: 747  G----TCSSDGM-GFHCTCP--PGVQGRQCEL--------------------LSPCTPNP 779
            G     C   G  GF   CP  PG      +L                      P T  P
Sbjct: 374  GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRP 433

Query: 780  C-----------EHGGRCESAPG-QLPVCSCPQGWQGPRCQQDVDECA----GPAPCGPH 823
                            R +  PG +LP+ S P  W GP   +           P  CGP 
Sbjct: 434  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIP-AWTGPEIPESGPSSGMCQRNPQVCGP- 491

Query: 824  GICTNLAGSFSCTCHGGY----TGPSCDQDINDCD--PNPCLNGGSCQDGVGSFSCSCLP 877
            G C +    ++C C  G+     G  C  D+++C   P PC   G C++  GSF C C P
Sbjct: 492  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCA-PGRCENSPGSFRCVCGP 549

Query: 878  GF-AGPRCAR--DVDEC--LSNPCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDC 928
            GF AGPR A   DVDEC  +  PC  G C +   SF C CP GY     G  C QD+ +C
Sbjct: 550  GFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDEC 608

Query: 929  --SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHG-GVCSAAHPGFR 985
              SP  C   G C +   SF C+C  G+ G+ C+ + D C   P   G G C      F 
Sbjct: 609  TQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFH 667

Query: 986  CTCLESF----TGPQCQTLVDWCSRQ--PCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRS 1037
            C C   F     G  CQ  VD C+R   PC   GRC  T G++ C+CP G+         
Sbjct: 668  CACPAGFRSRGPGAPCQD-VDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSEC 725

Query: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC-VCPEGR--TGSHCEQEVDPCL--AQP 1092
                E           L   G +CV+   S  C  CP G       C  +VD C   A P
Sbjct: 726  EDVDECE-------NHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPP 777

Query: 1093 CQHGGTCRGYMGGYMCECLPGYNGDNCED----DVDECASQP-CQHGGSCIDLVARYLCS 1147
            C   G C    G + C C PGY   +       DV+EC     C   G C++    + C+
Sbjct: 778  CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACT 837

Query: 1148 CP----PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG---L 1200
            C     PG  G  C ++ D+C       S      +G C +  G F C CPPG+     L
Sbjct: 838  CAPGYRPGPRGASC-LDVDEC-------SEEDLCQSGICTNTDGSFECICPPGHRAGPDL 889

Query: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCL--CHAGF-SGPR--CQTV-----LSP- 1249
                D++ECR        ++ C   P G +RC+  C  G+ +GP   C  V       P 
Sbjct: 890  ASCLDVDECRERGPALCGSQRCENSP-GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 948

Query: 1250 -CESQPCQH---GGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQ 1305
             C +Q C++     +C P+  PG          QP  G  C+ V        C     CQ
Sbjct: 949  ICGAQRCENTPGSYRCTPACDPG---------YQPTPGGGCQDVDECRNRSFCGAHAVCQ 999

Query: 1306 QTPRGPRCACPPGLSGP----------SCRSFPGSPPGASNASCAAAPC--LHGGSCRPA 1353
              P   +C C  G  G            C +  G         C AA C  + G      
Sbjct: 1000 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG--------VCGAALCENVEGSFLCVC 1051

Query: 1354 PLAP------FFRC----ACAQGWTGPRCEAPA-----AAPEVSEEPRCPRAACQAKRGD 1398
            P +P        RC      A  + G + +APA     A P     PR P    Q   G 
Sbjct: 1052 PNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1111

Query: 1399 QRCDRECNSPGCGWDGGDCSLSVGDPWRQC 1428
             R  REC       D  D  L+    W++C
Sbjct: 1112 GR--RECYFDTAAPDACDNILARNVTWQEC 1139



 Score =  166 bits (419), Expect = 3e-40
 Identities = 262/990 (26%), Positives = 341/990 (34%), Gaps = 215/990 (21%)

Query: 607  RCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPC 666
            RC  G TG  C      CA    T      G         PGF   LC +         C
Sbjct: 44   RCVHGPTGSRCTPT---CAPRNATS--VDSGAPGGAAPGGPGFRAFLCPLI--------C 90

Query: 667  GEGGSCVDGENGFRCLCPP------------GSLPPLCLPP-------SHPCA-HEPCSH 706
              GG CV  +   RCLCPP            G+ PP    P       + P A H    H
Sbjct: 91   HNGGVCVKPD---RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEH 147

Query: 707  GIC------YDAPGGFRCVCEP--GWSGP----------RCSQSLARDAC-------ESQ 741
            G+        + P     V       SGP          R   +   +A        +S 
Sbjct: 148  GVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSA 207

Query: 742  PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC--TPNPCEHGGRCESAPGQLPVCS-- 797
            P R  G   + G G+   C   ++G +C    P   T   C  G           +CS  
Sbjct: 208  P-REDGYSDASGFGY---CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSER 263

Query: 798  -------------CPQGWQGPRCQ-QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY-- 841
                         CP G++      +DVDECA    C  HG C N  G ++C C  G+  
Sbjct: 264  LGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRC-QHGECANTRGGYTCVCPDGFLL 322

Query: 842  --TGPSC-DQDINDCDPNPCL----NGGS-------------CQDGVGSF---SCSCLPG 878
              +  SC  Q +      PC     +GG              C   VG      C   P 
Sbjct: 323  DSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPP 382

Query: 879  F----------AGPRCARDVDECLSN--PCG---PGTCTDHVASFTCTCPPGYGGFHCEQ 923
            F          AGP       +   N  P G   P        +   T  P  G     +
Sbjct: 383  FGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHR 442

Query: 924  DLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP----CLSRPCLHG-GVCS 978
              P   P      G              P +TG     E+ P    C   P + G G C 
Sbjct: 443  LEPRPEPRPDPRPGP------ELPLPSIPAWTGPEIP-ESGPSSGMCQRNPQVCGPGRCI 495

Query: 979  AAHPGFRCTCLESFT----GPQCQTLVDWCSR--QPCQNGGRCVQT-GAY-CLCPPGWSG 1030
            +   G+ C C   F     G +C   VD C R   PC  G RC  + G++ C+C PG+  
Sbjct: 496  SRPSGYTCACDSGFRLSPQGTRCID-VDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRA 553

Query: 1031 RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRT----GSHCEQEVD 1086
                   L   E       R+   C  G +C +   S  CVCP G      G+ C Q+VD
Sbjct: 554  GPRAAECLDVDECH-----RVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASC-QDVD 606

Query: 1087 PCLAQPCQHG-GTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHG-GSCIDLVARY 1144
             C   P   G G C+   G + C C  G+ G  CE+DVDECA +P   G G C +    +
Sbjct: 607  ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF 666

Query: 1145 LCSCPPGTL----GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY--- 1197
             C+CP G      G  C+ + D+C   P     P C + G C +  G F+C CP G+   
Sbjct: 667  HCACPAGFRSRGPGAPCQ-DVDECARSP-----PPCTY-GRCENTEGSFQCVCPMGFQPN 719

Query: 1198 -TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRC-LCHAG--FSGPRCQTVLSPCES- 1252
              G  CE D++EC +    A   ++C+  PG  F+C  C +G      RC T +  C S 
Sbjct: 720  TAGSECE-DVDECENHL--ACPGQECVNSPGS-FQCRTCPSGHHLHRGRC-TDVDECSSG 774

Query: 1253 -QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPR-----CERVARSCRELQCPVGVPCQQ 1306
              PC   G C  + G     +F C CA  +  P      C  V        C     C  
Sbjct: 775  APPCGPHGHCTNTEG-----SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLN 829

Query: 1307 TPRGPRCACPPGLSGPSCRSFPGSPPGASNAS---CAAAPCLHGGSCRPAPLAPFFRCAC 1363
            T     C C PG         PG P GAS      C+       G C     +  F C C
Sbjct: 830  TDGSFACTCAPGYR-------PG-PRGASCLDVDECSEEDLCQSGICTNTDGS--FECIC 879

Query: 1364 AQGW-TGPRCEAPAAAPEVSEE--PRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS 1420
              G   GP   +     E  E     C    C+   G  RC R+C+        G C   
Sbjct: 880  PPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-D 938

Query: 1421 VGDPWRQ----CEALQCWRLFNNSRCDPAC 1446
            V +        C A +C     + RC PAC
Sbjct: 939  VDECQEYGPEICGAQRCENTPGSYRCTPAC 968



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 37/101 (36%), Positives = 46/101 (45%), Gaps = 21/101 (20%)

Query: 108 CPRGFRGPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCS---------------CPPGY 150
           C R  RG +C+ P P L +   C  GA  + G     LCS               CP G+
Sbjct: 222 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGF 281

Query: 151 Q--GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY 189
           +    SC  DVDEC  G  C+HG  C NT G + C CP G+
Sbjct: 282 ERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 1179 NGTCVDLVGGFRCTCPPGY----TGLRCEADINEC--RSGACHAAHTRDCLQDPGGGFRC 1232
            NG CV +  GF C C  GY    T + C  DINEC     A        CL +  G FRC
Sbjct: 1478 NGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCL-NTDGSFRC 1535

Query: 1233 LCHAGFS 1239
            +C  GF+
Sbjct: 1536 ICRPGFA 1542



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 13/95 (13%)

Query: 618  EVNIDDCAS-NPCTFGVCRDGINRYDCVCQPGF----TGPLCNVEINEC----ASSPCGE 668
            E+  ++C   + CT G C      + C C  G+    T   C V+INEC    A+SP   
Sbjct: 1464 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCV 1522

Query: 669  GGSCVDGENGFRCLCPPGSLP---PLCLPPSHPCA 700
               C++ +  FRC+C PG  P   P    P+ P A
Sbjct: 1523 NARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1557



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 13/71 (18%)

Query: 446 CLDRIGQFTCI------CMAGF--TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497
           C +R+G    +      C  GF      CE D+DEC +      G C +   G++C CP 
Sbjct: 260 CSERLGNSERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPD 318

Query: 498 GF----SGSTC 504
           GF    S S+C
Sbjct: 319 GFLLDSSRSSC 329



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 10/83 (12%)

Query: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPG-----TLGVLCEINEDDCGPGPPLDSGP 1174
            E + +EC        G C+ +   + C C  G     T     +INE D        + P
Sbjct: 1464 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEA----ASP 1519

Query: 1175 RCLHNGTCVDLVGGFRCTCPPGY 1197
             C+ N  C++  G FRC C PG+
Sbjct: 1520 LCV-NARCLNTDGSFRCICRPGF 1541



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 30/95 (31%), Positives = 35/95 (36%), Gaps = 18/95 (18%)

Query: 177 TPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVN 236
           TP     +C  G TG  C      CAP       T   SG         PGF    C + 
Sbjct: 37  TPVVCGLRCVHGPTGSRC---TPTCAP----RNATSVDSGAPGGAAPGGPGFRAFLCPLI 89

Query: 237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
                   C NGG CV       C CPP++ G+FC
Sbjct: 90  --------CHNGGVCV---KPDRCLCPPDFAGKFC 113



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 23/53 (43%), Positives = 26/53 (49%), Gaps = 18/53 (33%)

Query: 36  PGAAAPPCLDGSP----------CANGGRCTQLPSREAACLCPPGWVGERCQL 78
           PG AAP    G P          C NGG C + P R   CLCPP + G+ CQL
Sbjct: 71  PGGAAP----GGPGFRAFLCPLICHNGGVCVK-PDR---CLCPPDFAGKFCQL 115



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 31/108 (28%), Positives = 39/108 (36%), Gaps = 21/108 (19%)

Query: 715 GFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSP 774
           G RCV  P  +G RC+ + A     S    A G  +  G        PG +   C L+  
Sbjct: 42  GLRCVHGP--TGSRCTPTCAPRNATSVDSGAPGGAAPGG--------PGFRAFLCPLI-- 89

Query: 775 CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGP 822
                C +GG C         C CP  + G  CQ        PAP  P
Sbjct: 90  -----CHNGGVCVKPDR----CLCPPDFAGKFCQLHSSGARPPAPAVP 128



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 7/77 (9%)

Query: 1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE---DDVDEC----ASQPCQHG 1134
            E E + C        G C     G+ C C  GY  D       D++EC    A+ P    
Sbjct: 1464 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 1135 GSCIDLVARYLCSCPPG 1151
              C++    + C C PG
Sbjct: 1524 ARCLNTDGSFRCICRPG 1540



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 28/104 (26%), Positives = 35/104 (33%), Gaps = 28/104 (26%)

Query: 126 SPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP---------------CRH 170
           +P   G RC  GP G     C P    R+  S VD    G                 C +
Sbjct: 37  TPVVCGLRCVHGPTGS---RCTPTCAPRNATS-VDSGAPGGAAPGGPGFRAFLCPLICHN 92

Query: 171 GGTCLNTPGSFRCQCPAGYTGPLCE------NPAVPCAPSPCRN 208
           GG C+      RC CP  + G  C+       P  P  P   R+
Sbjct: 93  GGVCVKPD---RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRS 133



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 15/29 (51%), Positives = 16/29 (55%), Gaps = 3/29 (10%)

Query: 478 CVNGGVCKDRVNGFSCTCPSGFSGSTCQL 506
           C NGGVC   V    C CP  F+G  CQL
Sbjct: 90  CHNGGVC---VKPDRCLCPPDFAGKFCQL 115


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  305 bits (782), Expect = 3e-82
 Identities = 307/1021 (30%), Positives = 395/1021 (38%), Gaps = 227/1021 (22%)

Query: 2    GPG----ARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQ 57
            GPG    A   R   RP+   PP   +     L   + P A   P     P     R   
Sbjct: 425  GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP-RPDP 483

Query: 58   LPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
             P  E      P W G          SGP +G  +CQ                  R P  
Sbjct: 484  RPGPELPLPSIPAWTGPEIP-----ESGPSSG--MCQ------------------RNPQV 518

Query: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGT 173
              P  C+S P              + C+C  G+    QG  C  DVDECR   P    G 
Sbjct: 519  CGPGRCISRPSG------------YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR 565

Query: 174  CLNTPGSFRCQCPAGY-TGPLCENPAVPC--------APSPCRNGGTCRQSGDLTYDCAC 224
            C N+PGSFRC C  G+  GP     A  C         P PC  G      G  ++ C C
Sbjct: 566  CENSPGSFRCVCGPGFRAGP----RAAECLDVDECHRVPPPCDLGRCENTPG--SFLCVC 619

Query: 225  LPGFE----GQNCEVNVDDCPGHRCLNG-GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQ 279
              G++    G +C+ +VD+C     L G G C +   ++ C CP  + G  C EDVDEC 
Sbjct: 620  PAGYQAAPHGASCQ-DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECA 678

Query: 280  LQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCSQNIDDCATA--VCFHGATCHDRV 333
             +P  C   G C NT G   C C  G+     G  C Q++D+CA +   C +G  C +  
Sbjct: 679  QEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYG-RCENTE 735

Query: 334  ASFYCACPMG----KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC-TCPPG--FTGG 386
             SF C CPMG      G  C   D C ++       C  +P  G   C TCP G     G
Sbjct: 736  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP--GSFQCRTCPSGHHLHRG 793

Query: 387  ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE----TDVNECLSGP-CR 441
             C  DVDECS GA PC   G C NT+GSF C C  GY  P        DVNECL G  C 
Sbjct: 794  RC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 852

Query: 442  NQATCLDRIGQFTCICMAGF----TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497
                CL+  G F C C  G+     G  C +D+DEC        G+C +    F C CP 
Sbjct: 853  PHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPP 911

Query: 498  GFSG----STCQLDVDECAST-PCRNGA-KCVDQPDGYEC--RCAEGF----EGTLCDRN 545
            G       ++C LDVDEC    P   G+ +C + P  Y C   C  G+    EGT CD +
Sbjct: 912  GHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CD-D 968

Query: 546  VDDC---SPDPCHHGRCVDGIASFSC--ACAPGY---TGTRCESQVDECRSQP-CRHGGK 596
            VD+C    P+ C   RC +   S+ C  AC PGY    G  C+  VDECR++  C     
Sbjct: 969  VDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECRNRSFCGAHAV 1027

Query: 597  CLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNV 656
            C +L   + C C  G  G                    RDG +   C            V
Sbjct: 1028 CQNLPGSFQCLCDQGYEG-------------------ARDGRH---C------------V 1053

Query: 657  EINECAS--SPCGEGGSCVDGENGFRCLCP--PGSLPPL---CLPPSHPCAHEPCSHGIC 709
            ++NEC +    CG    C + E  F C+CP  P    P+   C+PP       P S    
Sbjct: 1054 DVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQA 1112

Query: 710  YDAP-----------------------GGFRCVCEPGWSGP-RCSQSLARDACESQPCRA 745
              +P                       G  R  C    + P  C   LAR+    + C  
Sbjct: 1113 PASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCT 1172

Query: 746  GGTCSSDGMGFHCTCP--PGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803
             G    +G G  C     PG +  + + L       C HG    +  G L +        
Sbjct: 1173 VG----EGWGSGCRIQQCPGTETAEYQSL-------CPHGRGYLAPSGDLSL-------- 1213

Query: 804  GPRCQQDVDECA--GPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNP 857
                ++DVDEC       C   G+C N A  +SC C  GY        C  +    D  P
Sbjct: 1214 ----RRDVDECQLFRDQVC-KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEP 1268

Query: 858  CLNGGSCQDGVGSFSCSCLPGF----AGPRCARDVDECLSNPCGPGTCTDHV-ASFTCTC 912
               GG C + VGS+ C+C P      +  RC  +  + L +    G C   V A   C+ 
Sbjct: 1269 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD--NLGVCWQEVGADLVCSH 1326

Query: 913  P 913
            P
Sbjct: 1327 P 1327



 Score =  300 bits (769), Expect = 8e-81
 Identities = 388/1371 (28%), Positives = 501/1371 (36%), Gaps = 341/1371 (24%)

Query: 249  GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-- 306
            G C  G    N  C          EDVDEC       H  G C NT GG++CVC +G+  
Sbjct: 305  GPCPTGFERVNGSC----------EDVDECATGGRCQH--GECANTRGGYTCVCPDGFLL 352

Query: 307  --TGESC-SQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHED 363
              +  SC SQ++   A   CF      D   S      + K    C          C   
Sbjct: 353  DSSRSSCISQHVISEAKGPCFR--VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ-- 408

Query: 364  AICDTNPVNG-RAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR- 421
             +C      G R IC   PG+   A D   +   +G  P     R   +Q   L    R 
Sbjct: 409  -LCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEP----PRVSLSQPRTLPATSRP 463

Query: 422  --------------------------------GYTGPRCETDVNECLSGPCRNQ------ 443
                                             +TGP  E   +   SG C+        
Sbjct: 464  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGP--EIPESGPSSGMCQRNPQVCGP 521

Query: 444  ATCLDRIGQFTCICMAGF----TGTYCEVDIDECQ--SSPCVNGGVCKDRVNGFSCTCPS 497
              C+ R   +TC C +GF     GT C +D+DEC+    PC  G  C++    F C C  
Sbjct: 522  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR-CENSPGSFRCVCGP 579

Query: 498  GF----SGSTCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFE----GTLCDRNVD 547
            GF      + C LDVDEC     PC  G +C + P  + C C  G++    G  C ++VD
Sbjct: 580  GFRAGPRAAEC-LDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASC-QDVD 636

Query: 548  DC--SPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHG-GKCLDLVDKY 604
            +C  SP  C  G C +   SF C C  G+ G+ CE  VDEC  +P   G G+C +    +
Sbjct: 637  ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF 696

Query: 605  LCRCPSG----TTGVNCEVNIDDCASN--PCTFGVCRDGINRYDCVC----QPGFTGPLC 654
             C CP+G      G  C+ ++D+CA +  PCT+G C +    + CVC    QP   G  C
Sbjct: 697  HCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 755

Query: 655  N---------------------------------------VEINECASS--PCGEGGSCV 673
                                                     +++EC+S   PCG  G C 
Sbjct: 756  EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT 815

Query: 674  DGENGFRCLCPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGW- 724
            + E  FRC C PG   P   P   PCA    C        HG C +  G F C C PG+ 
Sbjct: 816  NTEGSFRCSCAPGYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR 873

Query: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGG 784
             GPR +  L  D C  +     G C++    F C CPPG +    +L S    + C   G
Sbjct: 874  PGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP-DLASCLDVDECRERG 932

Query: 785  -------RCESAPGQLP-VCSCPQGWQ-GPR-CQQDVDECA--GPAPCGPHGICTNLAGS 832
                   RCE++PG    V  C  G+  GP     DVDEC   GP  CG    C N  GS
Sbjct: 933  PALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-CENTPGS 991

Query: 833  FSCT--CHGGY---TGPSCDQDINDC-DPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
            + CT  C  GY    G  C QD+++C + + C     CQ+  GSF C C  G+ G R  R
Sbjct: 992  YRCTPACDPGYQPTPGGGC-QDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGR 1050

Query: 887  ---DVDEC--LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVD 941
               DV+EC  L   CG   C +   SF C CP     F          P +    G CV 
Sbjct: 1051 HCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEF---------DPMT----GRCVP 1097

Query: 942  GVNSFSCLCRPGYTGAHCQHEADPCL-SRPCLHGGVCSAAHPGFRCTCLESFTGP-QCQT 999
               S        + G+  Q  A P L +RP           P    T  +   G  + + 
Sbjct: 1098 PRTSAGT-----FPGSQPQAPASPVLPARP------PPPPLPRRPSTPRQGPVGSGRREC 1146

Query: 1000 LVDWCSRQPCQNGGRCVQTGAYCLCP--PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
              D  +   C N      T   C C    GW G  C I+  P  E A       + LC  
Sbjct: 1147 YFDTAAPDACDNILARNVTWQECCCTVGEGW-GSGCRIQQCPGTETA-----EYQSLCPH 1200

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA---QPCQHGGTCRGYMGGYMCECLPGY 1114
            G            + P G       ++VD C     Q C+  G C     GY C C  GY
Sbjct: 1201 G---------RGYLAPSGDLS--LRRDVDECQLFRDQVCK-SGVCVNTAPGYSCYCSNGY 1248

Query: 1115 ----NGDNCEDDVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPP 1169
                    C D+ DECA  +P   GG C++ V  Y C+C P  +                
Sbjct: 1249 YYHTQRLECIDN-DECADEEPACEGGRCVNTVGSYHCTCEPPLV---------------- 1291

Query: 1170 LD-SGPRCLHN---------GTCVDLVGG-FRCTCPPGYTGLRCEADINECRSGACHAAH 1218
            LD S  RC+ N         G C   VG    C+ P     L  +A   EC    C    
Sbjct: 1292 LDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHP----RLDRQATYTEC----C---- 1339

Query: 1219 TRDCLQDPGGGFRC-LCHAGFSG---PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFT 1274
               CL     G  C LC A  S      C  +  P  S P       RP    G GL + 
Sbjct: 1340 ---CLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPP-------RPG---GFGLPYE 1386

Query: 1275 CHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGA 1334
                   +GP               +G P Q  P GP    PP L        P  PP  
Sbjct: 1387 -------YGP--------------DLGPPYQGLPYGPELYPPPALPYD-----PYPPPPG 1420

Query: 1335 SNASCAAAPCLHGGSCRPAPL-APFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQ 1393
              A             R AP  AP F     +   GP  E+ A AP      R P     
Sbjct: 1421 PFAR------------REAPYGAPRFDMPDFEDDGGPYGESEAPAPP-GPGTRWP----Y 1463

Query: 1394 AKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL--FNNSRC 1442
              R  +R   E   P    +GG  + S+ +P+ + EA +C  L    N RC
Sbjct: 1464 RSRDTRRSFPEPEEPP---EGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1511



 Score =  268 bits (685), Expect = 5e-71
 Identities = 292/1031 (28%), Positives = 390/1031 (37%), Gaps = 181/1031 (17%)

Query: 43   CLDGSPCANGGRCTQLPSREA----ACLCPPGWVGERCQLEDPCHS--------GPC--- 87
            C D   CA GGRC             C+CP G++ +  +    C S        GPC   
Sbjct: 318  CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSR--SSCISQHVISEAKGPCFRV 375

Query: 88   AGRGVCQSSVVAGTARFSCRCPRGFR--GPDCSLPDPCLSSPCAHGAR--CSVGPDGRFL 143
               G C   ++    +  C C R  +  G  C L  P  S     G R  C  GP   + 
Sbjct: 376  LRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSE----GFREICPAGPGYHYS 431

Query: 144  CSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE-------N 196
             S    Y  R    +     + +P     T   + G      P     P  E        
Sbjct: 432  AS-DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFL----PTHRLEPRPEPRPDPRPG 486

Query: 197  PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 256
            P +P    P   G    +SG                C+ N   C        G C+   +
Sbjct: 487  PELPLPSIPAWTGPEIPESGP-----------SSGMCQRNPQVC------GPGRCISRPS 529

Query: 257  TYNCQCPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-TGESC 311
             Y C C   +     G  C  DVDEC+  P  C  G  C N+ G   CVC  G+  G   
Sbjct: 530  GYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRA 587

Query: 312  SQ--NIDDC--ATAVCFHGATCHDRVASFYCACPMGKT----GLLCHLDDACVSNP--CH 361
            ++  ++D+C      C  G  C +   SF C CP G      G  C   D C  +P  C 
Sbjct: 588  AECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 646

Query: 362  EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR 421
              A C   P + R  C CP GF G AC++DVDEC+    PC   GRC NT GSF C C  
Sbjct: 647  RGA-CKNLPGSFR--CVCPAGFRGSACEEDVDECAQEPPPCGP-GRCDNTAGSFHCACPA 702

Query: 422  GYT----GPRCETDVNECL-SGPCRNQATCLDRIGQFTCICMAGF----TGTYCEVDIDE 472
            G+     G  C+ DV+EC  S P      C +  G F C+C  GF     G+ CE D+DE
Sbjct: 703  GFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDE 760

Query: 473  CQSSPCVNGGVCKDRVNGFSC-TCPSG--FSGSTCQLDVDECAS--TPCRNGAKCVDQPD 527
            C++     G  C +    F C TCPSG       C  DVDEC+S   PC     C +   
Sbjct: 761  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEG 819

Query: 528  GYECRCAEGFE------GTLCDRNV----DDCSPDPCHHGRCVDGIASFSCACAPGYT-- 575
             + C CA G+       G   D N     D C P    HG C++   SF+C CAPGY   
Sbjct: 820  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFP----HGECLNTDGSFACTCAPGYRPG 875

Query: 576  --GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG----VNCEVNIDDCASNP- 628
              G  C   VDEC  +     G C +    + C CP G        +C +++D+C     
Sbjct: 876  PRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGP 933

Query: 629  --CTFGVCRDGINRYDCV--CQPGF-TGP--LCNVEINECAS---SPCGEGGSCVDGENG 678
              C    C +    Y CV  C PG+  GP   C+ +++EC       CG    C +    
Sbjct: 934  ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICG-AQRCENTPGS 991

Query: 679  FRCL--CPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGWSGPR 728
            +RC   C PG  P     P   C   + C       +H +C + PG F+C+C+ G+ G R
Sbjct: 992  YRCTPACDPGYQPT----PGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR 1047

Query: 729  CSQSLAR-DACES-QPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG--- 783
              +     + CE+ Q       C +    F C CP   +     +   C P     G   
Sbjct: 1048 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD-PMTGRCVPPRTSAGTFP 1106

Query: 784  GRCESAPGQ--LPVCSCP-----------QGWQGPRCQQDVDECAGPAPCGPHGICTNLA 830
            G    AP    LP    P           QG  G   ++   + A P  C  + +  N+ 
Sbjct: 1107 GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACD-NILARNVT 1165

Query: 831  GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGS-CQDGVGSFSCSCLPGFAGPRCARDVD 889
                C   G   G  C   I  C         S C  G G  + S           RDVD
Sbjct: 1166 WQECCCTVGEGWGSGCR--IQQCPGTETAEYQSLCPHGRGYLAPS-----GDLSLRRDVD 1218

Query: 890  ECL---SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ----DLPDCSPSS-CFNGGTCVD 941
            EC       C  G C +    ++C C  GY  +H ++    D  +C+       GG CV+
Sbjct: 1219 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEGGRCVN 1277

Query: 942  GVNSFSCLCRP 952
             V S+ C C P
Sbjct: 1278 TVGSYHCTCEP 1288



 Score =  266 bits (680), Expect = 2e-70
 Identities = 297/1046 (28%), Positives = 404/1046 (38%), Gaps = 224/1046 (21%)

Query: 341  PMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400
            P GK  +LC L        CH   +C   P      C CPP F G  C          A 
Sbjct: 108  PAGKAPVLCPLI-------CHNGGVC-VKPDR----CLCPPDFAGKFCQLHSSGARPPAP 155

Query: 401  PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN------------ECLSGPCRNQATCLD 448
                L R V T      +             V             E +SGP        +
Sbjct: 156  AVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADA--E 213

Query: 449  RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNG-------GVCKDRVNGFSCTCPSG--- 498
             + +      A     Y  +     QS+P  +G       G C   + G  C  P     
Sbjct: 214  AVARAEAAARAEAAAPYTVL----AQSAPREDGYSDASGFGYCFRELRGGECASPLPGLR 269

Query: 499  -----FSGSTCQLDVDECASTPCRNG-AKCVDQPDGYECRCAEGFEGT--LCDRNVDDCS 550
                   G+     V +C     R G ++ V  PDG    C  GFE     C+ +VD+C+
Sbjct: 270  TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDG---PCPTGFERVNGSCE-DVDECA 325

Query: 551  PDP-CHHGRCVDGIASFSCACAPGY----TGTRCESQ--VDECRSQPC----RHGGKCLD 599
                C HG C +    ++C C  G+    + + C SQ  + E +  PC    R GG  L 
Sbjct: 326  TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKG-PCFRVLRDGGCSLP 384

Query: 600  L---VDKYLCRCP--SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLC 654
            +   + K +C C       G  C++    C      FG   +G  R  C   PG+     
Sbjct: 385  ILRNITKQICCCSRVGKAWGRGCQL----CP----PFG--SEGF-REICPAGPGYHYSAS 433

Query: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP-------------------- 694
            ++  N   + P G+    V        L  P +LP    P                    
Sbjct: 434  DLRYN---TRPLGQEPPRVS-------LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDP 483

Query: 695  --------PSHP----------------CAHEP--CSHGICYDAPGGFRCVCEPGWS-GP 727
                    PS P                C   P  C  G C   P G+ C C+ G+   P
Sbjct: 484  RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSP 543

Query: 728  RCSQSLARDACE--SQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPC--TPNP 779
            + ++ +  D C     PC A G C +    F C C PG     +  +C  +  C   P P
Sbjct: 544  QGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPP 602

Query: 780  CEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECA-GPAPCGPHGICTNLAGSFS 834
            C+  GRCE+ PG   +C CP G+Q    G  C QDVDEC   P  CG  G C NL GSF 
Sbjct: 603  CDL-GRCENTPGSF-LCVCPAGYQAAPHGASC-QDVDECTQSPGLCG-RGACKNLPGSFR 658

Query: 835  CTCHGGYTGPSCDQDINDC--DPNPCLNGGSCQDGVGSFSCSCLPGF--AGPRC-ARDVD 889
            C C  G+ G +C++D+++C  +P PC   G C +  GSF C+C  GF   GP    +DVD
Sbjct: 659  CVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVD 717

Query: 890  ECLSN--PCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDCSPSSCFNGGTCVDGV 943
            EC  +  PC  G C +   SF C CP G+     G  CE D+ +C       G  CV+  
Sbjct: 718  ECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSP 776

Query: 944  NSFSCLCRPGYTGAHCQH----EADPCLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQ- 996
             SF C   P  +G H       + D C S   PC   G C+     FRC+C   +  P  
Sbjct: 777  GSFQCRTCP--SGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 834

Query: 997  ----CQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVR 1050
                C  + +      C   G C+ T G++ C C PG+         L   E +      
Sbjct: 835  RPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSE----- 889

Query: 1051 LEQLCQAGGQCVDEDSSHYCVCPEG-RTGSHCEQ--EVDPCLAQ-PCQHGG-TCRGYMGG 1105
             E LCQ+ G C + D S  C+CP G R G       +VD C  + P   G   C    G 
Sbjct: 890  -EDLCQS-GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGS 947

Query: 1106 YMC--ECLPGYNG--DNCEDDVDECASQPCQHGGS--CIDLVARYLC--SCPPG---TLG 1154
            Y C  +C PGY+   +   DDVDEC     +  G+  C +    Y C  +C PG   T G
Sbjct: 948  YRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPG 1007

Query: 1155 VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR----CEADINECR 1210
              C+ + D+C       +   C  +  C +L G F+C C  GY G R    C  D+NEC 
Sbjct: 1008 GGCQ-DVDEC------RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECE 1059

Query: 1211 S--GACHAAHTRDCLQDPGGGFRCLC 1234
            +  G C AA      ++  G F C+C
Sbjct: 1060 TLQGVCGAA----LCENVEGSFLCVC 1081



 Score =  263 bits (671), Expect = 2e-69
 Identities = 325/1112 (29%), Positives = 436/1112 (39%), Gaps = 223/1112 (20%)

Query: 486  DRVNGFSCTCPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGFEGTLC 542
            +RV+     CP+GF     +C+ DVDECA+   C++G +C +   GY C C +GF   L 
Sbjct: 298  ERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF---LL 352

Query: 543  DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPC----RHGGKCL 598
            D +   C             I+    + A G                PC    R GG  L
Sbjct: 353  DSSRSSC-------------ISQHVISEAKG----------------PCFRVLRDGGCSL 383

Query: 599  DL---VDKYLCRCP--SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPL 653
             +   + K +C C       G  C++    C      FG   +G  R  C   PG+    
Sbjct: 384  PILRNITKQICCCSRVGKAWGRGCQL----CP----PFG--SEGF-REICPAGPGYHYSA 432

Query: 654  CNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP-----PSHPCAHEPCSHGI 708
             ++  N   + P G+    V        L  P +LP    P     P+H     P     
Sbjct: 433  SDLRYN---TRPLGQEPPRVS-------LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 482

Query: 709  CYDAPGGFRCVCEPGWSGPRCSQS-LARDACESQPCRAG-GTCSSDGMGFHCTCPPGV-- 764
                P        P W+GP   +S  +   C+  P   G G C S   G+ C C  G   
Sbjct: 483  PRPGP-ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 541

Query: 765  --QGRQCELLSPC--TPNPCEHGGRCESAPGQLPVCSCPQGWQ-GPRCQQ--DVDECAGP 817
              QG +C  +  C   P PC   GRCE++PG    C C  G++ GPR  +  DVDEC   
Sbjct: 542  SPQGTRCIDVDECRRVPPPCA-PGRCENSPGSFR-CVCGPGFRAGPRAAECLDVDECHRV 599

Query: 818  APCGPHGICTNLAGSFSCTCHGGYT----GPSCDQDINDCDPNPCLNG-GSCQDGVGSFS 872
             P    G C N  GSF C C  GY     G SC QD+++C  +P L G G+C++  GSF 
Sbjct: 600  PPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQSPGLCGRGACKNLPGSFR 658

Query: 873  CSCLPGFAGPRCARDVDECLSN--PCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLP 926
            C C  GF G  C  DVDEC     PCGPG C +   SF C CP G+     G  C QD+ 
Sbjct: 659  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVD 717

Query: 927  DC--SPSSCFNGGTCVDGVNSFSCLC----RPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
            +C  SP  C   G C +   SF C+C    +P   G+ C+ + D C +     G  C  +
Sbjct: 718  ECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNS 775

Query: 981  HPGFRCTCLES---FTGPQCQTLVDWCS--RQPCQNGGRCVQT-GAY-CLCPPGWSGRLC 1033
               F+C    S       +C T VD CS    PC   G C  T G++ C C PG+  R  
Sbjct: 776  PGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--RAP 832

Query: 1034 DIRSLPCREAAAQIGVRLE-QLCQAGGQCVDEDSSHYCVCP----EGRTGSHCEQEVDPC 1088
              R  PC    A +   LE   C   G+C++ D S  C C      G  G+ C  +VD C
Sbjct: 833  SGRPGPC----ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDEC 887

Query: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGD----NCEDDVDECASQPCQHGGS--CIDLVA 1142
              +     G C    G + C C PG+       +C  DVDEC  +     GS  C +   
Sbjct: 888  SEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCL-DVDECRERGPALCGSQRCENSPG 946

Query: 1143 RYLC--SCPPGTLG---VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT--CPP 1195
             Y C   C PG        C+ + D+C      + GP       C +  G +RCT  C P
Sbjct: 947  SYRCVRDCDPGYHAGPEGTCD-DVDEC-----QEYGPEICGAQRCENTPGSYRCTPACDP 1000

Query: 1196 GY---TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            GY    G  C+ D++ECR+ +   AH     Q+  G F+CLC  G+ G R        + 
Sbjct: 1001 GYQPTPGGGCQ-DVDECRNRSFCGAHA--VCQNLPGSFQCLCDQGYEGAR--------DG 1049

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
            + C    +C    G  G                CE V  S     CP   P +  P   R
Sbjct: 1050 RHCVDVNECETLQGVCGAAL-------------CENVEGSFL-CVCP-NSPEEFDPMTGR 1094

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGP-- 1370
            C  P   +G    +FPGS P A      A+P L      P P  P       QG  G   
Sbjct: 1095 CVPPRTSAG----TFPGSQPQA-----PASPVLPARP--PPPPLPRRPSTPRQGPVGSGR 1143

Query: 1371 -RCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQC- 1428
              C    AAP+  +               Q C   C + G GW G  C +      +QC 
Sbjct: 1144 RECYFDTAAPDACDNILARNVTW------QEC---CCTVGEGW-GSGCRI------QQCP 1187

Query: 1429 --EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN--------PVYEKYCAD- 1477
              E  +   L  + R   A S    L  + D     R++ C         P Y  YC++ 
Sbjct: 1188 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1247

Query: 1478 ---HFADGRC--DQGCNTEECGWDGLDCASEV 1504
               H     C  +  C  EE   +G  C + V
Sbjct: 1248 YYYHTQRLECIDNDECADEEPACEGGRCVNTV 1279



 Score =  250 bits (639), Expect = 1e-65
 Identities = 310/1099 (28%), Positives = 401/1099 (36%), Gaps = 249/1099 (22%)

Query: 48   PCANGGRCTQLPSREAACLCPPGW-VGER---CQLEDPCHS-GPCAGRGVCQSSVVAGTA 102
            PCA G RC   P     C+C PG+  G R   C   D CH   P    G C+++      
Sbjct: 560  PCAPG-RCENSPG-SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT----PG 613

Query: 103  RFSCRCPRGFR----GPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
             F C CP G++    G  C   D C  SP  C  GA C   P G F C CP G++G +C 
Sbjct: 614  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLP-GSFRCVCPAGFRGSACE 671

Query: 157  SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC--------APSPCRN 208
             DVDEC    P    G C NT GSF C CPAG+       P  PC        +P PC  
Sbjct: 672  EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRS---RGPGAPCQDVDECARSPPPCTY 728

Query: 209  GGTCRQSGDLTYDCACLPGFE----GQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP 264
            G      G  ++ C C  GF+    G  CE +VD+C  H    G  CV+   ++ C+  P
Sbjct: 729  GRCENTEG--SFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCP 785

Query: 265  E----WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGES-----CSQNI 315
                   G+ CT DVDEC      C   G C NT G   C C  G+   S     C+ ++
Sbjct: 786  SGHHLHRGR-CT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA-DV 842

Query: 316  DDCATA-VCFHGATCHDRVASFYCACP----MGKTGLLCHLDDACVSNPCHEDAICDTNP 370
            ++C     CF    C +   SF C C      G  G  C   D C      +  IC TN 
Sbjct: 843  NECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC-TN- 900

Query: 371  VNGRAICTCPPGFTGG---ACDQDVDECSIGANPCEHLGRCVNTQGSFLC--QCGRGY-T 424
             +G   C CPPG   G   A   DVDEC           RC N+ GS+ C   C  GY  
Sbjct: 901  TDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA 960

Query: 425  GPR--CETDVNECLS-GP--CRNQATCLDRIGQFTC--ICMAGF---TGTYCEVDIDECQ 474
            GP   C+ DV+EC   GP  C  Q  C +  G + C   C  G+    G  C+ D+DEC+
Sbjct: 961  GPEGTCD-DVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECR 1017

Query: 475  S-SPCVNGGVCKDRVNGFSCTCPSGFSGST----CQLDVDECASTPCRNGAKCVDQPDG- 528
            + S C    VC++    F C C  G+ G+     C +DV+EC +     GA   +  +G 
Sbjct: 1018 NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCGAALCENVEGS 1076

Query: 529  YECRC--------------------AEGFEGTLCDRNVDDCSP----------------- 551
            + C C                    A  F G+          P                 
Sbjct: 1077 FLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQ 1136

Query: 552  DPCHHGR---CVDGIASFSC--ACAPGYTGTRCESQVDE-----CRSQPCRHGGKCLDLV 601
             P   GR     D  A  +C    A   T   C   V E     CR Q C          
Sbjct: 1137 GPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETA---- 1192

Query: 602  DKYLCRCPSG------TTGVNCEVNIDDC---ASNPCTFGVCRDGINRYDCVCQPGF--- 649
             +Y   CP G      +  ++   ++D+C       C  GVC +    Y C C  G+   
Sbjct: 1193 -EYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYH 1251

Query: 650  TGPLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPS-HPCAHEPCSH- 706
            T  L  ++ +ECA   P  EGG CV+    + C C     PPL L  S   C        
Sbjct: 1252 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCE----PPLVLDGSQRRCVSNESQSL 1307

Query: 707  ----GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP 762
                G+C+   G    VC    S PR    L R A  ++ C   G    +  G  C   P
Sbjct: 1308 DDNLGVCWQEVGA-DLVC----SHPR----LDRQATYTECCCLYG----EAWGMDCALCP 1354

Query: 763  GVQGRQ----CELLSPCTPNPCEHGG---------------------------------R 785
                      C +L P   +P   GG                                  
Sbjct: 1355 AQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDP 1414

Query: 786  CESAPGQLPVCSCPQG---WQGPRCQQD---VDECAGPAPCGPHGICTNLAGSFSCTCHG 839
                PG       P G   +  P  + D     E   PAP GP                 
Sbjct: 1415 YPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGP----------------- 1457

Query: 840  GYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC-LSNPCGP 898
            G   P   +D     P P        +G GS++ S     A P    + +EC + + C  
Sbjct: 1458 GTRWPYRSRDTRRSFPEP----EEPPEG-GSYAGS----LAEPYEELEAEECGILDGCTN 1508

Query: 899  GTCTDHVASFTCTCPPGY----GGFHC----EQDLPDCSPSSCFNGGTCVDGVNSFSCLC 950
            G C      FTC C  GY        C    E D  + +   C N   C++   SF C+C
Sbjct: 1509 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCIC 1567

Query: 951  RPGYTGAHCQHEADPCLSR 969
            RPG+   H  H   P   R
Sbjct: 1568 RPGFAPTHQPHHCAPARPR 1586



 Score =  240 bits (612), Expect = 1e-62
 Identities = 279/990 (28%), Positives = 370/990 (37%), Gaps = 203/990 (20%)

Query: 570  CAPGYTGTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
            C     G  C S +   R+Q   CR  G    + D  LC   S   G +  V+  D    
Sbjct: 252  CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLC---SERLGNSERVSAPD---- 304

Query: 628  PCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGS 687
                G C  G  R +  C+          +++ECA+    + G C +   G+ C+CP G 
Sbjct: 305  ----GPCPTGFERVNGSCE----------DVDECATGGRCQHGECANTRGGYTCVCPDGF 350

Query: 688  LPPLCLPPSHPCAHEPCSHGICYDAPGG-FRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
            L    L  S        S  +  +A G  FR + + G S P       +  C S+  +A 
Sbjct: 351  L----LDSSRSSC---ISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAW 403

Query: 747  G----TCSSDGM-GFHCTCP--PGVQGRQCEL--------------------LSPCTPNP 779
            G     C   G  GF   CP  PG      +L                      P T  P
Sbjct: 404  GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRP 463

Query: 780  C-----------EHGGRCESAPG-QLPVCSCPQGWQGPRCQQDVDECA----GPAPCGPH 823
                            R +  PG +LP+ S P  W GP   +           P  CGP 
Sbjct: 464  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIP-AWTGPEIPESGPSSGMCQRNPQVCGP- 521

Query: 824  GICTNLAGSFSCTCHGGY----TGPSCDQDINDCD--PNPCLNGGSCQDGVGSFSCSCLP 877
            G C +    ++C C  G+     G  C  D+++C   P PC   G C++  GSF C C P
Sbjct: 522  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCA-PGRCENSPGSFRCVCGP 579

Query: 878  GF-AGPRCAR--DVDEC--LSNPCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDC 928
            GF AGPR A   DVDEC  +  PC  G C +   SF C CP GY     G  C QD+ +C
Sbjct: 580  GFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDEC 638

Query: 929  --SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHG-GVCSAAHPGFR 985
              SP  C   G C +   SF C+C  G+ G+ C+ + D C   P   G G C      F 
Sbjct: 639  TQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFH 697

Query: 986  CTCLESF----TGPQCQTLVDWCSRQ--PCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRS 1037
            C C   F     G  CQ  VD C+R   PC   GRC  T G++ C+CP G+         
Sbjct: 698  CACPAGFRSRGPGAPCQD-VDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSEC 755

Query: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC-VCPEGR--TGSHCEQEVDPCL--AQP 1092
                E           L   G +CV+   S  C  CP G       C  +VD C   A P
Sbjct: 756  EDVDECE-------NHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPP 807

Query: 1093 CQHGGTCRGYMGGYMCECLPGYNGDNCED----DVDECASQP-CQHGGSCIDLVARYLCS 1147
            C   G C    G + C C PGY   +       DV+EC     C   G C++    + C+
Sbjct: 808  CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACT 867

Query: 1148 CP----PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG---L 1200
            C     PG  G  C ++ D+C       S      +G C +  G F C CPPG+     L
Sbjct: 868  CAPGYRPGPRGASC-LDVDEC-------SEEDLCQSGICTNTDGSFECICPPGHRAGPDL 919

Query: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCL--CHAGF-SGPR--CQTV-----LSP- 1249
                D++ECR        ++ C   P G +RC+  C  G+ +GP   C  V       P 
Sbjct: 920  ASCLDVDECRERGPALCGSQRCENSP-GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 978

Query: 1250 -CESQPCQH---GGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQ 1305
             C +Q C++     +C P+  PG          QP  G  C+ V        C     CQ
Sbjct: 979  ICGAQRCENTPGSYRCTPACDPG---------YQPTPGGGCQDVDECRNRSFCGAHAVCQ 1029

Query: 1306 QTPRGPRCACPPGLSGP----------SCRSFPGSPPGASNASCAAAPC--LHGGSCRPA 1353
              P   +C C  G  G            C +  G         C AA C  + G      
Sbjct: 1030 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG--------VCGAALCENVEGSFLCVC 1081

Query: 1354 PLAP------FFRC----ACAQGWTGPRCEAPA-----AAPEVSEEPRCPRAACQAKRGD 1398
            P +P        RC      A  + G + +APA     A P     PR P    Q   G 
Sbjct: 1082 PNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1141

Query: 1399 QRCDRECNSPGCGWDGGDCSLSVGDPWRQC 1428
             R  REC       D  D  L+    W++C
Sbjct: 1142 GR--RECYFDTAAPDACDNILARNVTWQEC 1169



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 37/101 (36%), Positives = 46/101 (45%), Gaps = 21/101 (20%)

Query: 108 CPRGFRGPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCS---------------CPPGY 150
           C R  RG +C+ P P L +   C  GA  + G     LCS               CP G+
Sbjct: 252 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGF 311

Query: 151 Q--GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY 189
           +    SC  DVDEC  G  C+HG  C NT G + C CP G+
Sbjct: 312 ERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 350



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/77 (38%), Positives = 34/77 (44%), Gaps = 23/77 (29%)

Query: 2   GPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSR 61
           GPG RG  RRR P   P    PV   PL+                  C NGG C + P R
Sbjct: 92  GPGGRGLLRRRPPQRAPAGKAPVLC-PLI------------------CHNGGVCVK-PDR 131

Query: 62  EAACLCPPGWVGERCQL 78
              CLCPP + G+ CQL
Sbjct: 132 ---CLCPPDFAGKFCQL 145



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 1179 NGTCVDLVGGFRCTCPPGY----TGLRCEADINEC--RSGACHAAHTRDCLQDPGGGFRC 1232
            NG CV +  GF C C  GY    T + C  DINEC     A        CL +  G FRC
Sbjct: 1508 NGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCL-NTDGSFRC 1565

Query: 1233 LCHAGFS 1239
            +C  GF+
Sbjct: 1566 ICRPGFA 1572



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 13/95 (13%)

Query: 618  EVNIDDCAS-NPCTFGVCRDGINRYDCVCQPGF----TGPLCNVEINEC----ASSPCGE 668
            E+  ++C   + CT G C      + C C  G+    T   C V+INEC    A+SP   
Sbjct: 1494 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCV 1552

Query: 669  GGSCVDGENGFRCLCPPGSLP---PLCLPPSHPCA 700
               C++ +  FRC+C PG  P   P    P+ P A
Sbjct: 1553 NARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1587



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 10/83 (12%)

Query: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPG-----TLGVLCEINEDDCGPGPPLDSGP 1174
            E + +EC        G C+ +   + C C  G     T     +INE D        + P
Sbjct: 1494 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEA----ASP 1549

Query: 1175 RCLHNGTCVDLVGGFRCTCPPGY 1197
             C+ N  C++  G FRC C PG+
Sbjct: 1550 LCV-NARCLNTDGSFRCICRPGF 1571



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 3/27 (11%)

Query: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFC 271
           C NGG CV       C CPP++ G+FC
Sbjct: 120 CHNGGVCV---KPDRCLCPPDFAGKFC 143



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 7/77 (9%)

Query: 1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE---DDVDEC----ASQPCQHG 1134
            E E + C        G C     G+ C C  GY  D       D++EC    A+ P    
Sbjct: 1494 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 1135 GSCIDLVARYLCSCPPG 1151
              C++    + C C PG
Sbjct: 1554 ARCLNTDGSFRCICRPG 1570



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 3/58 (5%)

Query: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE 1082
            P G  GR    R  P R  A +  V    +C  GG CV  D    C+CP    G  C+
Sbjct: 90   PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDR---CLCPPDFAGKFCQ 144


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  305 bits (782), Expect = 3e-82
 Identities = 307/1021 (30%), Positives = 395/1021 (38%), Gaps = 227/1021 (22%)

Query: 2    GPG----ARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQ 57
            GPG    A   R   RP+   PP   +     L   + P A   P     P     R   
Sbjct: 462  GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP-RPDP 520

Query: 58   LPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
             P  E      P W G          SGP +G  +CQ                  R P  
Sbjct: 521  RPGPELPLPSIPAWTGPEIP-----ESGPSSG--MCQ------------------RNPQV 555

Query: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGT 173
              P  C+S P              + C+C  G+    QG  C  DVDECR   P    G 
Sbjct: 556  CGPGRCISRPSG------------YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR 602

Query: 174  CLNTPGSFRCQCPAGY-TGPLCENPAVPC--------APSPCRNGGTCRQSGDLTYDCAC 224
            C N+PGSFRC C  G+  GP     A  C         P PC  G      G  ++ C C
Sbjct: 603  CENSPGSFRCVCGPGFRAGP----RAAECLDVDECHRVPPPCDLGRCENTPG--SFLCVC 656

Query: 225  LPGFE----GQNCEVNVDDCPGHRCLNG-GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQ 279
              G++    G +C+ +VD+C     L G G C +   ++ C CP  + G  C EDVDEC 
Sbjct: 657  PAGYQAAPHGASCQ-DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECA 715

Query: 280  LQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCSQNIDDCATA--VCFHGATCHDRV 333
             +P  C   G C NT G   C C  G+     G  C Q++D+CA +   C +G  C +  
Sbjct: 716  QEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYG-RCENTE 772

Query: 334  ASFYCACPMG----KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC-TCPPG--FTGG 386
             SF C CPMG      G  C   D C ++       C  +P  G   C TCP G     G
Sbjct: 773  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP--GSFQCRTCPSGHHLHRG 830

Query: 387  ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE----TDVNECLSGP-CR 441
             C  DVDECS GA PC   G C NT+GSF C C  GY  P        DVNECL G  C 
Sbjct: 831  RC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 889

Query: 442  NQATCLDRIGQFTCICMAGF----TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497
                CL+  G F C C  G+     G  C +D+DEC        G+C +    F C CP 
Sbjct: 890  PHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPP 948

Query: 498  GFSG----STCQLDVDECAST-PCRNGA-KCVDQPDGYEC--RCAEGF----EGTLCDRN 545
            G       ++C LDVDEC    P   G+ +C + P  Y C   C  G+    EGT CD +
Sbjct: 949  GHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CD-D 1005

Query: 546  VDDC---SPDPCHHGRCVDGIASFSC--ACAPGY---TGTRCESQVDECRSQP-CRHGGK 596
            VD+C    P+ C   RC +   S+ C  AC PGY    G  C+  VDECR++  C     
Sbjct: 1006 VDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECRNRSFCGAHAV 1064

Query: 597  CLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNV 656
            C +L   + C C  G  G                    RDG +   C            V
Sbjct: 1065 CQNLPGSFQCLCDQGYEG-------------------ARDGRH---C------------V 1090

Query: 657  EINECAS--SPCGEGGSCVDGENGFRCLCP--PGSLPPL---CLPPSHPCAHEPCSHGIC 709
            ++NEC +    CG    C + E  F C+CP  P    P+   C+PP       P S    
Sbjct: 1091 DVNECETLQGVCG-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQA 1149

Query: 710  YDAP-----------------------GGFRCVCEPGWSGP-RCSQSLARDACESQPCRA 745
              +P                       G  R  C    + P  C   LAR+    + C  
Sbjct: 1150 PASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCT 1209

Query: 746  GGTCSSDGMGFHCTCP--PGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803
             G    +G G  C     PG +  + + L       C HG    +  G L +        
Sbjct: 1210 VG----EGWGSGCRIQQCPGTETAEYQSL-------CPHGRGYLAPSGDLSL-------- 1250

Query: 804  GPRCQQDVDECA--GPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNP 857
                ++DVDEC       C   G+C N A  +SC C  GY        C  +    D  P
Sbjct: 1251 ----RRDVDECQLFRDQVC-KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEP 1305

Query: 858  CLNGGSCQDGVGSFSCSCLPGF----AGPRCARDVDECLSNPCGPGTCTDHV-ASFTCTC 912
               GG C + VGS+ C+C P      +  RC  +  + L +    G C   V A   C+ 
Sbjct: 1306 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDD--NLGVCWQEVGADLVCSH 1363

Query: 913  P 913
            P
Sbjct: 1364 P 1364



 Score =  300 bits (769), Expect = 8e-81
 Identities = 388/1371 (28%), Positives = 501/1371 (36%), Gaps = 341/1371 (24%)

Query: 249  GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-- 306
            G C  G    N  C          EDVDEC       H  G C NT GG++CVC +G+  
Sbjct: 342  GPCPTGFERVNGSC----------EDVDECATGGRCQH--GECANTRGGYTCVCPDGFLL 389

Query: 307  --TGESC-SQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHED 363
              +  SC SQ++   A   CF      D   S      + K    C          C   
Sbjct: 390  DSSRSSCISQHVISEAKGPCFR--VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ-- 445

Query: 364  AICDTNPVNG-RAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR- 421
             +C      G R IC   PG+   A D   +   +G  P     R   +Q   L    R 
Sbjct: 446  -LCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEP----PRVSLSQPRTLPATSRP 500

Query: 422  --------------------------------GYTGPRCETDVNECLSGPCRNQ------ 443
                                             +TGP  E   +   SG C+        
Sbjct: 501  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGP--EIPESGPSSGMCQRNPQVCGP 558

Query: 444  ATCLDRIGQFTCICMAGF----TGTYCEVDIDECQ--SSPCVNGGVCKDRVNGFSCTCPS 497
              C+ R   +TC C +GF     GT C +D+DEC+    PC  G  C++    F C C  
Sbjct: 559  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPGR-CENSPGSFRCVCGP 616

Query: 498  GF----SGSTCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFE----GTLCDRNVD 547
            GF      + C LDVDEC     PC  G +C + P  + C C  G++    G  C ++VD
Sbjct: 617  GFRAGPRAAEC-LDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASC-QDVD 673

Query: 548  DC--SPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHG-GKCLDLVDKY 604
            +C  SP  C  G C +   SF C C  G+ G+ CE  VDEC  +P   G G+C +    +
Sbjct: 674  ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF 733

Query: 605  LCRCPSG----TTGVNCEVNIDDCASN--PCTFGVCRDGINRYDCVC----QPGFTGPLC 654
             C CP+G      G  C+ ++D+CA +  PCT+G C +    + CVC    QP   G  C
Sbjct: 734  HCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 792

Query: 655  N---------------------------------------VEINECASS--PCGEGGSCV 673
                                                     +++EC+S   PCG  G C 
Sbjct: 793  EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT 852

Query: 674  DGENGFRCLCPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGW- 724
            + E  FRC C PG   P   P   PCA    C        HG C +  G F C C PG+ 
Sbjct: 853  NTEGSFRCSCAPGYRAPSGRP--GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR 910

Query: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGG 784
             GPR +  L  D C  +     G C++    F C CPPG +    +L S    + C   G
Sbjct: 911  PGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP-DLASCLDVDECRERG 969

Query: 785  -------RCESAPGQLP-VCSCPQGWQ-GPR-CQQDVDECA--GPAPCGPHGICTNLAGS 832
                   RCE++PG    V  C  G+  GP     DVDEC   GP  CG    C N  GS
Sbjct: 970  PALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-CENTPGS 1028

Query: 833  FSCT--CHGGY---TGPSCDQDINDC-DPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
            + CT  C  GY    G  C QD+++C + + C     CQ+  GSF C C  G+ G R  R
Sbjct: 1029 YRCTPACDPGYQPTPGGGC-QDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGR 1087

Query: 887  ---DVDEC--LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVD 941
               DV+EC  L   CG   C +   SF C CP     F          P +    G CV 
Sbjct: 1088 HCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEF---------DPMT----GRCVP 1134

Query: 942  GVNSFSCLCRPGYTGAHCQHEADPCL-SRPCLHGGVCSAAHPGFRCTCLESFTGP-QCQT 999
               S        + G+  Q  A P L +RP           P    T  +   G  + + 
Sbjct: 1135 PRTSAGT-----FPGSQPQAPASPVLPARP------PPPPLPRRPSTPRQGPVGSGRREC 1183

Query: 1000 LVDWCSRQPCQNGGRCVQTGAYCLCP--PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
              D  +   C N      T   C C    GW G  C I+  P  E A       + LC  
Sbjct: 1184 YFDTAAPDACDNILARNVTWQECCCTVGEGW-GSGCRIQQCPGTETA-----EYQSLCPH 1237

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA---QPCQHGGTCRGYMGGYMCECLPGY 1114
            G            + P G       ++VD C     Q C+  G C     GY C C  GY
Sbjct: 1238 G---------RGYLAPSGDLS--LRRDVDECQLFRDQVCK-SGVCVNTAPGYSCYCSNGY 1285

Query: 1115 ----NGDNCEDDVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPP 1169
                    C D+ DECA  +P   GG C++ V  Y C+C P  +                
Sbjct: 1286 YYHTQRLECIDN-DECADEEPACEGGRCVNTVGSYHCTCEPPLV---------------- 1328

Query: 1170 LD-SGPRCLHN---------GTCVDLVGG-FRCTCPPGYTGLRCEADINECRSGACHAAH 1218
            LD S  RC+ N         G C   VG    C+ P     L  +A   EC    C    
Sbjct: 1329 LDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHP----RLDRQATYTEC----C---- 1376

Query: 1219 TRDCLQDPGGGFRC-LCHAGFSG---PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFT 1274
               CL     G  C LC A  S      C  +  P  S P       RP    G GL + 
Sbjct: 1377 ---CLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPP-------RPG---GFGLPYE 1423

Query: 1275 CHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGA 1334
                   +GP               +G P Q  P GP    PP L        P  PP  
Sbjct: 1424 -------YGP--------------DLGPPYQGLPYGPELYPPPALPYD-----PYPPPPG 1457

Query: 1335 SNASCAAAPCLHGGSCRPAPL-APFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQ 1393
              A             R AP  AP F     +   GP  E+ A AP      R P     
Sbjct: 1458 PFAR------------REAPYGAPRFDMPDFEDDGGPYGESEAPAPP-GPGTRWP----Y 1500

Query: 1394 AKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL--FNNSRC 1442
              R  +R   E   P    +GG  + S+ +P+ + EA +C  L    N RC
Sbjct: 1501 RSRDTRRSFPEPEEPP---EGGSYAGSLAEPYEELEAEECGILDGCTNGRC 1548



 Score =  268 bits (685), Expect = 5e-71
 Identities = 292/1031 (28%), Positives = 390/1031 (37%), Gaps = 181/1031 (17%)

Query: 43   CLDGSPCANGGRCTQLPSREA----ACLCPPGWVGERCQLEDPCHS--------GPC--- 87
            C D   CA GGRC             C+CP G++ +  +    C S        GPC   
Sbjct: 355  CEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSR--SSCISQHVISEAKGPCFRV 412

Query: 88   AGRGVCQSSVVAGTARFSCRCPRGFR--GPDCSLPDPCLSSPCAHGAR--CSVGPDGRFL 143
               G C   ++    +  C C R  +  G  C L  P  S     G R  C  GP   + 
Sbjct: 413  LRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSE----GFREICPAGPGYHYS 468

Query: 144  CSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE-------N 196
             S    Y  R    +     + +P     T   + G      P     P  E        
Sbjct: 469  AS-DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFL----PTHRLEPRPEPRPDPRPG 523

Query: 197  PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN 256
            P +P    P   G    +SG                C+ N   C        G C+   +
Sbjct: 524  PELPLPSIPAWTGPEIPESGP-----------SSGMCQRNPQVC------GPGRCISRPS 566

Query: 257  TYNCQCPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW-TGESC 311
             Y C C   +     G  C  DVDEC+  P  C  G  C N+ G   CVC  G+  G   
Sbjct: 567  GYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRA 624

Query: 312  SQ--NIDDC--ATAVCFHGATCHDRVASFYCACPMGKT----GLLCHLDDACVSNP--CH 361
            ++  ++D+C      C  G  C +   SF C CP G      G  C   D C  +P  C 
Sbjct: 625  AECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCG 683

Query: 362  EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGR 421
              A C   P + R  C CP GF G AC++DVDEC+    PC   GRC NT GSF C C  
Sbjct: 684  RGA-CKNLPGSFR--CVCPAGFRGSACEEDVDECAQEPPPCGP-GRCDNTAGSFHCACPA 739

Query: 422  GYT----GPRCETDVNECL-SGPCRNQATCLDRIGQFTCICMAGF----TGTYCEVDIDE 472
            G+     G  C+ DV+EC  S P      C +  G F C+C  GF     G+ CE D+DE
Sbjct: 740  GFRSRGPGAPCQ-DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDE 797

Query: 473  CQSSPCVNGGVCKDRVNGFSC-TCPSG--FSGSTCQLDVDECAS--TPCRNGAKCVDQPD 527
            C++     G  C +    F C TCPSG       C  DVDEC+S   PC     C +   
Sbjct: 798  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEG 856

Query: 528  GYECRCAEGFE------GTLCDRNV----DDCSPDPCHHGRCVDGIASFSCACAPGYT-- 575
             + C CA G+       G   D N     D C P    HG C++   SF+C CAPGY   
Sbjct: 857  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFP----HGECLNTDGSFACTCAPGYRPG 912

Query: 576  --GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG----VNCEVNIDDCASNP- 628
              G  C   VDEC  +     G C +    + C CP G        +C +++D+C     
Sbjct: 913  PRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGP 970

Query: 629  --CTFGVCRDGINRYDCV--CQPGF-TGP--LCNVEINECAS---SPCGEGGSCVDGENG 678
              C    C +    Y CV  C PG+  GP   C+ +++EC       CG    C +    
Sbjct: 971  ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICG-AQRCENTPGS 1028

Query: 679  FRCL--CPPGSLPPLCLPPSHPCAH-EPC-------SHGICYDAPGGFRCVCEPGWSGPR 728
            +RC   C PG  P     P   C   + C       +H +C + PG F+C+C+ G+ G R
Sbjct: 1029 YRCTPACDPGYQPT----PGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR 1084

Query: 729  CSQSLAR-DACES-QPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG--- 783
              +     + CE+ Q       C +    F C CP   +     +   C P     G   
Sbjct: 1085 DGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD-PMTGRCVPPRTSAGTFP 1143

Query: 784  GRCESAPGQ--LPVCSCP-----------QGWQGPRCQQDVDECAGPAPCGPHGICTNLA 830
            G    AP    LP    P           QG  G   ++   + A P  C  + +  N+ 
Sbjct: 1144 GSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACD-NILARNVT 1202

Query: 831  GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGS-CQDGVGSFSCSCLPGFAGPRCARDVD 889
                C   G   G  C   I  C         S C  G G  + S           RDVD
Sbjct: 1203 WQECCCTVGEGWGSGCR--IQQCPGTETAEYQSLCPHGRGYLAPS-----GDLSLRRDVD 1255

Query: 890  ECL---SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ----DLPDCSPSS-CFNGGTCVD 941
            EC       C  G C +    ++C C  GY  +H ++    D  +C+       GG CV+
Sbjct: 1256 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEGGRCVN 1314

Query: 942  GVNSFSCLCRP 952
             V S+ C C P
Sbjct: 1315 TVGSYHCTCEP 1325



 Score =  266 bits (680), Expect = 2e-70
 Identities = 297/1046 (28%), Positives = 404/1046 (38%), Gaps = 224/1046 (21%)

Query: 341  PMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400
            P GK  +LC L        CH   +C   P      C CPP F G  C          A 
Sbjct: 145  PAGKAPVLCPLI-------CHNGGVC-VKPDR----CLCPPDFAGKFCQLHSSGARPPAP 192

Query: 401  PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN------------ECLSGPCRNQATCLD 448
                L R V T      +             V             E +SGP        +
Sbjct: 193  AVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADA--E 250

Query: 449  RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNG-------GVCKDRVNGFSCTCPSG--- 498
             + +      A     Y  +     QS+P  +G       G C   + G  C  P     
Sbjct: 251  AVARAEAAARAEAAAPYTVL----AQSAPREDGYSDASGFGYCFRELRGGECASPLPGLR 306

Query: 499  -----FSGSTCQLDVDECASTPCRNG-AKCVDQPDGYECRCAEGFEGT--LCDRNVDDCS 550
                   G+     V +C     R G ++ V  PDG    C  GFE     C+ +VD+C+
Sbjct: 307  TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDG---PCPTGFERVNGSCE-DVDECA 362

Query: 551  PDP-CHHGRCVDGIASFSCACAPGY----TGTRCESQ--VDECRSQPC----RHGGKCLD 599
                C HG C +    ++C C  G+    + + C SQ  + E +  PC    R GG  L 
Sbjct: 363  TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKG-PCFRVLRDGGCSLP 421

Query: 600  L---VDKYLCRCP--SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLC 654
            +   + K +C C       G  C++    C      FG   +G  R  C   PG+     
Sbjct: 422  ILRNITKQICCCSRVGKAWGRGCQL----CP----PFG--SEGF-REICPAGPGYHYSAS 470

Query: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP-------------------- 694
            ++  N   + P G+    V        L  P +LP    P                    
Sbjct: 471  DLRYN---TRPLGQEPPRVS-------LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDP 520

Query: 695  --------PSHP----------------CAHEP--CSHGICYDAPGGFRCVCEPGWS-GP 727
                    PS P                C   P  C  G C   P G+ C C+ G+   P
Sbjct: 521  RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSP 580

Query: 728  RCSQSLARDACE--SQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPC--TPNP 779
            + ++ +  D C     PC A G C +    F C C PG     +  +C  +  C   P P
Sbjct: 581  QGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPP 639

Query: 780  CEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECA-GPAPCGPHGICTNLAGSFS 834
            C+  GRCE+ PG   +C CP G+Q    G  C QDVDEC   P  CG  G C NL GSF 
Sbjct: 640  CDL-GRCENTPGSF-LCVCPAGYQAAPHGASC-QDVDECTQSPGLCG-RGACKNLPGSFR 695

Query: 835  CTCHGGYTGPSCDQDINDC--DPNPCLNGGSCQDGVGSFSCSCLPGF--AGPRC-ARDVD 889
            C C  G+ G +C++D+++C  +P PC   G C +  GSF C+C  GF   GP    +DVD
Sbjct: 696  CVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVD 754

Query: 890  ECLSN--PCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDCSPSSCFNGGTCVDGV 943
            EC  +  PC  G C +   SF C CP G+     G  CE D+ +C       G  CV+  
Sbjct: 755  ECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSP 813

Query: 944  NSFSCLCRPGYTGAHCQH----EADPCLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQ- 996
             SF C   P  +G H       + D C S   PC   G C+     FRC+C   +  P  
Sbjct: 814  GSFQCRTCP--SGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 871

Query: 997  ----CQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVR 1050
                C  + +      C   G C+ T G++ C C PG+         L   E +      
Sbjct: 872  RPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSE----- 926

Query: 1051 LEQLCQAGGQCVDEDSSHYCVCPEG-RTGSHCEQ--EVDPCLAQ-PCQHGG-TCRGYMGG 1105
             E LCQ+ G C + D S  C+CP G R G       +VD C  + P   G   C    G 
Sbjct: 927  -EDLCQS-GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGS 984

Query: 1106 YMC--ECLPGYNG--DNCEDDVDECASQPCQHGGS--CIDLVARYLC--SCPPG---TLG 1154
            Y C  +C PGY+   +   DDVDEC     +  G+  C +    Y C  +C PG   T G
Sbjct: 985  YRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPG 1044

Query: 1155 VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR----CEADINECR 1210
              C+ + D+C       +   C  +  C +L G F+C C  GY G R    C  D+NEC 
Sbjct: 1045 GGCQ-DVDEC------RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECE 1096

Query: 1211 S--GACHAAHTRDCLQDPGGGFRCLC 1234
            +  G C AA      ++  G F C+C
Sbjct: 1097 TLQGVCGAA----LCENVEGSFLCVC 1118



 Score =  263 bits (671), Expect = 2e-69
 Identities = 325/1112 (29%), Positives = 436/1112 (39%), Gaps = 223/1112 (20%)

Query: 486  DRVNGFSCTCPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGFEGTLC 542
            +RV+     CP+GF     +C+ DVDECA+   C++G +C +   GY C C +GF   L 
Sbjct: 335  ERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF---LL 389

Query: 543  DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPC----RHGGKCL 598
            D +   C             I+    + A G                PC    R GG  L
Sbjct: 390  DSSRSSC-------------ISQHVISEAKG----------------PCFRVLRDGGCSL 420

Query: 599  DL---VDKYLCRCP--SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPL 653
             +   + K +C C       G  C++    C      FG   +G  R  C   PG+    
Sbjct: 421  PILRNITKQICCCSRVGKAWGRGCQL----CP----PFG--SEGF-REICPAGPGYHYSA 469

Query: 654  CNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP-----PSHPCAHEPCSHGI 708
             ++  N   + P G+    V        L  P +LP    P     P+H     P     
Sbjct: 470  SDLRYN---TRPLGQEPPRVS-------LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 519

Query: 709  CYDAPGGFRCVCEPGWSGPRCSQS-LARDACESQPCRAG-GTCSSDGMGFHCTCPPGV-- 764
                P        P W+GP   +S  +   C+  P   G G C S   G+ C C  G   
Sbjct: 520  PRPGP-ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 578

Query: 765  --QGRQCELLSPC--TPNPCEHGGRCESAPGQLPVCSCPQGWQ-GPRCQQ--DVDECAGP 817
              QG +C  +  C   P PC   GRCE++PG    C C  G++ GPR  +  DVDEC   
Sbjct: 579  SPQGTRCIDVDECRRVPPPCA-PGRCENSPGSFR-CVCGPGFRAGPRAAECLDVDECHRV 636

Query: 818  APCGPHGICTNLAGSFSCTCHGGYT----GPSCDQDINDCDPNPCLNG-GSCQDGVGSFS 872
             P    G C N  GSF C C  GY     G SC QD+++C  +P L G G+C++  GSF 
Sbjct: 637  PPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQSPGLCGRGACKNLPGSFR 695

Query: 873  CSCLPGFAGPRCARDVDECLSN--PCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLP 926
            C C  GF G  C  DVDEC     PCGPG C +   SF C CP G+     G  C QD+ 
Sbjct: 696  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC-QDVD 754

Query: 927  DC--SPSSCFNGGTCVDGVNSFSCLC----RPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
            +C  SP  C   G C +   SF C+C    +P   G+ C+ + D C +     G  C  +
Sbjct: 755  ECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNS 812

Query: 981  HPGFRCTCLES---FTGPQCQTLVDWCS--RQPCQNGGRCVQT-GAY-CLCPPGWSGRLC 1033
               F+C    S       +C T VD CS    PC   G C  T G++ C C PG+  R  
Sbjct: 813  PGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--RAP 869

Query: 1034 DIRSLPCREAAAQIGVRLE-QLCQAGGQCVDEDSSHYCVCP----EGRTGSHCEQEVDPC 1088
              R  PC    A +   LE   C   G+C++ D S  C C      G  G+ C  +VD C
Sbjct: 870  SGRPGPC----ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDEC 924

Query: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGD----NCEDDVDECASQPCQHGGS--CIDLVA 1142
              +     G C    G + C C PG+       +C  DVDEC  +     GS  C +   
Sbjct: 925  SEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCL-DVDECRERGPALCGSQRCENSPG 983

Query: 1143 RYLC--SCPPGTLG---VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT--CPP 1195
             Y C   C PG        C+ + D+C      + GP       C +  G +RCT  C P
Sbjct: 984  SYRCVRDCDPGYHAGPEGTCD-DVDEC-----QEYGPEICGAQRCENTPGSYRCTPACDP 1037

Query: 1196 GY---TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES 1252
            GY    G  C+ D++ECR+ +   AH     Q+  G F+CLC  G+ G R        + 
Sbjct: 1038 GYQPTPGGGCQ-DVDECRNRSFCGAHA--VCQNLPGSFQCLCDQGYEGAR--------DG 1086

Query: 1253 QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPR 1312
            + C    +C    G  G                CE V  S     CP   P +  P   R
Sbjct: 1087 RHCVDVNECETLQGVCGAAL-------------CENVEGSFL-CVCP-NSPEEFDPMTGR 1131

Query: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGP-- 1370
            C  P   +G    +FPGS P A      A+P L      P P  P       QG  G   
Sbjct: 1132 CVPPRTSAG----TFPGSQPQA-----PASPVLPARP--PPPPLPRRPSTPRQGPVGSGR 1180

Query: 1371 -RCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQC- 1428
              C    AAP+  +               Q C   C + G GW G  C +      +QC 
Sbjct: 1181 RECYFDTAAPDACDNILARNVTW------QEC---CCTVGEGW-GSGCRI------QQCP 1224

Query: 1429 --EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN--------PVYEKYCAD- 1477
              E  +   L  + R   A S    L  + D     R++ C         P Y  YC++ 
Sbjct: 1225 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1284

Query: 1478 ---HFADGRC--DQGCNTEECGWDGLDCASEV 1504
               H     C  +  C  EE   +G  C + V
Sbjct: 1285 YYYHTQRLECIDNDECADEEPACEGGRCVNTV 1316



 Score =  250 bits (639), Expect = 1e-65
 Identities = 310/1099 (28%), Positives = 401/1099 (36%), Gaps = 249/1099 (22%)

Query: 48   PCANGGRCTQLPSREAACLCPPGW-VGER---CQLEDPCHS-GPCAGRGVCQSSVVAGTA 102
            PCA G RC   P     C+C PG+  G R   C   D CH   P    G C+++      
Sbjct: 597  PCAPG-RCENSPG-SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT----PG 650

Query: 103  RFSCRCPRGFR----GPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
             F C CP G++    G  C   D C  SP  C  GA C   P G F C CP G++G +C 
Sbjct: 651  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLP-GSFRCVCPAGFRGSACE 708

Query: 157  SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC--------APSPCRN 208
             DVDEC    P    G C NT GSF C CPAG+       P  PC        +P PC  
Sbjct: 709  EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRS---RGPGAPCQDVDECARSPPPCTY 765

Query: 209  GGTCRQSGDLTYDCACLPGFE----GQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP 264
            G      G  ++ C C  GF+    G  CE +VD+C  H    G  CV+   ++ C+  P
Sbjct: 766  GRCENTEG--SFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCP 822

Query: 265  E----WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGES-----CSQNI 315
                   G+ CT DVDEC      C   G C NT G   C C  G+   S     C+ ++
Sbjct: 823  SGHHLHRGR-CT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA-DV 879

Query: 316  DDCATA-VCFHGATCHDRVASFYCACP----MGKTGLLCHLDDACVSNPCHEDAICDTNP 370
            ++C     CF    C +   SF C C      G  G  C   D C      +  IC TN 
Sbjct: 880  NECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC-TN- 937

Query: 371  VNGRAICTCPPGFTGG---ACDQDVDECSIGANPCEHLGRCVNTQGSFLC--QCGRGY-T 424
             +G   C CPPG   G   A   DVDEC           RC N+ GS+ C   C  GY  
Sbjct: 938  TDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA 997

Query: 425  GPR--CETDVNECLS-GP--CRNQATCLDRIGQFTC--ICMAGF---TGTYCEVDIDECQ 474
            GP   C+ DV+EC   GP  C  Q  C +  G + C   C  G+    G  C+ D+DEC+
Sbjct: 998  GPEGTCD-DVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQPTPGGGCQ-DVDECR 1054

Query: 475  S-SPCVNGGVCKDRVNGFSCTCPSGFSGST----CQLDVDECASTPCRNGAKCVDQPDG- 528
            + S C    VC++    F C C  G+ G+     C +DV+EC +     GA   +  +G 
Sbjct: 1055 NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCGAALCENVEGS 1113

Query: 529  YECRC--------------------AEGFEGTLCDRNVDDCSP----------------- 551
            + C C                    A  F G+          P                 
Sbjct: 1114 FLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQ 1173

Query: 552  DPCHHGR---CVDGIASFSC--ACAPGYTGTRCESQVDE-----CRSQPCRHGGKCLDLV 601
             P   GR     D  A  +C    A   T   C   V E     CR Q C          
Sbjct: 1174 GPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETA---- 1229

Query: 602  DKYLCRCPSG------TTGVNCEVNIDDC---ASNPCTFGVCRDGINRYDCVCQPGF--- 649
             +Y   CP G      +  ++   ++D+C       C  GVC +    Y C C  G+   
Sbjct: 1230 -EYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYH 1288

Query: 650  TGPLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPS-HPCAHEPCSH- 706
            T  L  ++ +ECA   P  EGG CV+    + C C     PPL L  S   C        
Sbjct: 1289 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCE----PPLVLDGSQRRCVSNESQSL 1344

Query: 707  ----GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPP 762
                G+C+   G    VC    S PR    L R A  ++ C   G    +  G  C   P
Sbjct: 1345 DDNLGVCWQEVGA-DLVC----SHPR----LDRQATYTECCCLYG----EAWGMDCALCP 1391

Query: 763  GVQGRQ----CELLSPCTPNPCEHGG---------------------------------R 785
                      C +L P   +P   GG                                  
Sbjct: 1392 AQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDP 1451

Query: 786  CESAPGQLPVCSCPQG---WQGPRCQQD---VDECAGPAPCGPHGICTNLAGSFSCTCHG 839
                PG       P G   +  P  + D     E   PAP GP                 
Sbjct: 1452 YPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGP----------------- 1494

Query: 840  GYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC-LSNPCGP 898
            G   P   +D     P P        +G GS++ S     A P    + +EC + + C  
Sbjct: 1495 GTRWPYRSRDTRRSFPEP----EEPPEG-GSYAGS----LAEPYEELEAEECGILDGCTN 1545

Query: 899  GTCTDHVASFTCTCPPGY----GGFHC----EQDLPDCSPSSCFNGGTCVDGVNSFSCLC 950
            G C      FTC C  GY        C    E D  + +   C N   C++   SF C+C
Sbjct: 1546 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCIC 1604

Query: 951  RPGYTGAHCQHEADPCLSR 969
            RPG+   H  H   P   R
Sbjct: 1605 RPGFAPTHQPHHCAPARPR 1623



 Score =  240 bits (612), Expect = 1e-62
 Identities = 279/990 (28%), Positives = 370/990 (37%), Gaps = 203/990 (20%)

Query: 570  CAPGYTGTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
            C     G  C S +   R+Q   CR  G    + D  LC   S   G +  V+  D    
Sbjct: 289  CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLC---SERLGNSERVSAPD---- 341

Query: 628  PCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGS 687
                G C  G  R +  C+          +++ECA+    + G C +   G+ C+CP G 
Sbjct: 342  ----GPCPTGFERVNGSCE----------DVDECATGGRCQHGECANTRGGYTCVCPDGF 387

Query: 688  LPPLCLPPSHPCAHEPCSHGICYDAPGG-FRCVCEPGWSGPRCSQSLARDACESQPCRAG 746
            L    L  S        S  +  +A G  FR + + G S P       +  C S+  +A 
Sbjct: 388  L----LDSSRSSC---ISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAW 440

Query: 747  G----TCSSDGM-GFHCTCP--PGVQGRQCEL--------------------LSPCTPNP 779
            G     C   G  GF   CP  PG      +L                      P T  P
Sbjct: 441  GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRP 500

Query: 780  C-----------EHGGRCESAPG-QLPVCSCPQGWQGPRCQQDVDECA----GPAPCGPH 823
                            R +  PG +LP+ S P  W GP   +           P  CGP 
Sbjct: 501  SAGFLPTHRLEPRPEPRPDPRPGPELPLPSIP-AWTGPEIPESGPSSGMCQRNPQVCGP- 558

Query: 824  GICTNLAGSFSCTCHGGY----TGPSCDQDINDCD--PNPCLNGGSCQDGVGSFSCSCLP 877
            G C +    ++C C  G+     G  C  D+++C   P PC   G C++  GSF C C P
Sbjct: 559  GRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCA-PGRCENSPGSFRCVCGP 616

Query: 878  GF-AGPRCAR--DVDEC--LSNPCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPDC 928
            GF AGPR A   DVDEC  +  PC  G C +   SF C CP GY     G  C QD+ +C
Sbjct: 617  GFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDEC 675

Query: 929  --SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHG-GVCSAAHPGFR 985
              SP  C   G C +   SF C+C  G+ G+ C+ + D C   P   G G C      F 
Sbjct: 676  TQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFH 734

Query: 986  CTCLESF----TGPQCQTLVDWCSRQ--PCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRS 1037
            C C   F     G  CQ  VD C+R   PC   GRC  T G++ C+CP G+         
Sbjct: 735  CACPAGFRSRGPGAPCQD-VDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSEC 792

Query: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC-VCPEGR--TGSHCEQEVDPCL--AQP 1092
                E           L   G +CV+   S  C  CP G       C  +VD C   A P
Sbjct: 793  EDVDECE-------NHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC-TDVDECSSGAPP 844

Query: 1093 CQHGGTCRGYMGGYMCECLPGYNGDNCED----DVDECASQP-CQHGGSCIDLVARYLCS 1147
            C   G C    G + C C PGY   +       DV+EC     C   G C++    + C+
Sbjct: 845  CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACT 904

Query: 1148 CP----PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG---L 1200
            C     PG  G  C ++ D+C       S      +G C +  G F C CPPG+     L
Sbjct: 905  CAPGYRPGPRGASC-LDVDEC-------SEEDLCQSGICTNTDGSFECICPPGHRAGPDL 956

Query: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCL--CHAGF-SGPR--CQTV-----LSP- 1249
                D++ECR        ++ C   P G +RC+  C  G+ +GP   C  V       P 
Sbjct: 957  ASCLDVDECRERGPALCGSQRCENSP-GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 1015

Query: 1250 -CESQPCQH---GGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQ 1305
             C +Q C++     +C P+  PG          QP  G  C+ V        C     CQ
Sbjct: 1016 ICGAQRCENTPGSYRCTPACDPG---------YQPTPGGGCQDVDECRNRSFCGAHAVCQ 1066

Query: 1306 QTPRGPRCACPPGLSGP----------SCRSFPGSPPGASNASCAAAPC--LHGGSCRPA 1353
              P   +C C  G  G            C +  G         C AA C  + G      
Sbjct: 1067 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQG--------VCGAALCENVEGSFLCVC 1118

Query: 1354 PLAP------FFRC----ACAQGWTGPRCEAPA-----AAPEVSEEPRCPRAACQAKRGD 1398
            P +P        RC      A  + G + +APA     A P     PR P    Q   G 
Sbjct: 1119 PNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1178

Query: 1399 QRCDRECNSPGCGWDGGDCSLSVGDPWRQC 1428
             R  REC       D  D  L+    W++C
Sbjct: 1179 GR--RECYFDTAAPDACDNILARNVTWQEC 1206



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 37/101 (36%), Positives = 46/101 (45%), Gaps = 21/101 (20%)

Query: 108 CPRGFRGPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCS---------------CPPGY 150
           C R  RG +C+ P P L +   C  GA  + G     LCS               CP G+
Sbjct: 289 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGF 348

Query: 151 Q--GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY 189
           +    SC  DVDEC  G  C+HG  C NT G + C CP G+
Sbjct: 349 ERVNGSCE-DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/77 (38%), Positives = 34/77 (44%), Gaps = 23/77 (29%)

Query: 2   GPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSR 61
           GPG RG  RRR P   P    PV   PL+                  C NGG C + P R
Sbjct: 129 GPGGRGLLRRRPPQRAPAGKAPVLC-PLI------------------CHNGGVCVK-PDR 168

Query: 62  EAACLCPPGWVGERCQL 78
              CLCPP + G+ CQL
Sbjct: 169 ---CLCPPDFAGKFCQL 182



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 1179 NGTCVDLVGGFRCTCPPGY----TGLRCEADINEC--RSGACHAAHTRDCLQDPGGGFRC 1232
            NG CV +  GF C C  GY    T + C  DINEC     A        CL +  G FRC
Sbjct: 1545 NGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCL-NTDGSFRC 1602

Query: 1233 LCHAGFS 1239
            +C  GF+
Sbjct: 1603 ICRPGFA 1609



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 13/95 (13%)

Query: 618  EVNIDDCAS-NPCTFGVCRDGINRYDCVCQPGF----TGPLCNVEINEC----ASSPCGE 668
            E+  ++C   + CT G C      + C C  G+    T   C V+INEC    A+SP   
Sbjct: 1531 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCV 1589

Query: 669  GGSCVDGENGFRCLCPPGSLP---PLCLPPSHPCA 700
               C++ +  FRC+C PG  P   P    P+ P A
Sbjct: 1590 NARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1624



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 57/234 (24%), Positives = 74/234 (31%), Gaps = 65/234 (27%)

Query: 3   PGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSRE 62
           PG  GRR             P+  + LL L A   +AA P    S           P+  
Sbjct: 4   PGTSGRR-------------PLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASV 50

Query: 63  AACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDP 122
           A C C PG    R +    C    C  R  CQ    AG  R             C  P P
Sbjct: 51  AVCRCCPGQTSRRSR----CIRAFCRVRS-CQPKKCAGPQR-------------CLNPVP 92

Query: 123 CLSSPCAHGARCSV----------------------GPDGRFLCSCPPGYQGRSCRSDVD 160
            + SP     +  V                      GP GR L    P  +  + ++ V 
Sbjct: 93  AVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPV- 151

Query: 161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE------NPAVPCAPSPCRN 208
            C +   C +GG C+      RC CP  + G  C+       P  P  P   R+
Sbjct: 152 LCPL--ICHNGGVCVKPD---RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRS 200



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 10/83 (12%)

Query: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPG-----TLGVLCEINEDDCGPGPPLDSGP 1174
            E + +EC        G C+ +   + C C  G     T     +INE D        + P
Sbjct: 1531 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEA----ASP 1586

Query: 1175 RCLHNGTCVDLVGGFRCTCPPGY 1197
             C+ N  C++  G FRC C PG+
Sbjct: 1587 LCV-NARCLNTDGSFRCICRPGF 1608



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 3/27 (11%)

Query: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFC 271
           C NGG CV       C CPP++ G+FC
Sbjct: 157 CHNGGVCV---KPDRCLCPPDFAGKFC 180



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 7/77 (9%)

Query: 1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE---DDVDEC----ASQPCQHG 1134
            E E + C        G C     G+ C C  GY  D       D++EC    A+ P    
Sbjct: 1531 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 1135 GSCIDLVARYLCSCPPG 1151
              C++    + C C PG
Sbjct: 1591 ARCLNTDGSFRCICRPG 1607



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 3/58 (5%)

Query: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE 1082
            P G  GR    R  P R  A +  V    +C  GG CV  D    C+CP    G  C+
Sbjct: 127  PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDR---CLCPPDFAGKFCQ 181


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  279 bits (714), Expect = 2e-74
 Identities = 251/868 (28%), Positives = 324/868 (37%), Gaps = 243/868 (27%)

Query: 41  PPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGP-CAGRGVCQSSVV 98
           P C D   C +G RC         C C PGW G  C    D  H GP C  R  C++  +
Sbjct: 107 PHCAD--KCVHG-RCIA----PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGAL 159

Query: 99  AGTARFSCRCPRGFRGPDCSLPDPC----LSSPCAHGARCSVGPDGRFL---CSCPPGYQ 151
                 +C C  GFRG  C   D C      + C    +C  G     +   C CPPGY 
Sbjct: 160 CNPITGACHCAAGFRGWRCE--DRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYT 217

Query: 152 GRSCR------SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP----- 200
           G  C           +C    PC++GG C +  G   C CP+G+ G +C  P        
Sbjct: 218 GAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEGRFGK 275

Query: 201 -CAPS-PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258
            C+    C NGGTC  +   T  C C PG+ G+ C+   D+CP             V TY
Sbjct: 276 NCSQECQCHNGGTCDAA---TGQCHCSPGYTGERCQ---DECP-------------VGTY 316

Query: 259 NCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDC 318
              C             + CQ     C NGG C++  G  +C+C  G+ GE C   +   
Sbjct: 317 GVLC------------AETCQ-----CVNGGKCYHVSG--ACLCEAGFAGERCEARL--- 354

Query: 319 ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC- 377
                                CP G  G+ C  D  C   PCH +     +P++G   C 
Sbjct: 355 ---------------------CPEGLYGIKC--DKRC---PCHLENTHSCHPMSGECACK 388

Query: 378 ----------TCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPR 427
                     TC PGF G AC Q +  C  GA+       C +  G   C C  G+ G  
Sbjct: 389 PGWSGLYCNETCSPGFYGEAC-QQICSCQNGAD-------CDSVTGK--CTCAPGFKGID 438

Query: 428 CET-------DVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSS---- 476
           C T        +N      C+N A C    G  +C C AG+ G  C +    C S     
Sbjct: 439 CSTPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCSI---RCPSGTWGF 493

Query: 477 ------PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE------CAS-TPCRNGAKCV 523
                  C+NGG C + ++G +CTC  G+ G  C+L   +      CA    C +   C 
Sbjct: 494 GCNLTCQCLNGGAC-NTLDG-TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGC- 550

Query: 524 DQPDGYECRCAEGFEGTLCD------------------RNVDDCSPDP--CHHGRCVDGI 563
             P    CRC  G+ G  CD                  +N   CSPD   C    C  G 
Sbjct: 551 -HPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC---ECAPGF 606

Query: 564 ASFSC--ACAPGYTGTRCESQVDEC--RSQPCRHGGKCLDLVDKY---LCR--CPSGTTG 614
              +C   C+PG+ G RC     +C   S PC H     D +  +   LC   CPSG  G
Sbjct: 607 RGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFG 666

Query: 615 VNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVD 674
            NC   I  C +N    G C + I+R  C C PG+ G  C        S P         
Sbjct: 667 KNC-AGICTCTNN----GTC-NPIDR-SCQCYPGWIGSDC--------SQP--------- 702

Query: 675 GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS-- 732
                   CPP    P C+   H C    C +G    A  G  C C PGW+G  C+Q   
Sbjct: 703 --------CPPAHWGPNCI---HTC---NCHNGAFCSAYDG-ECKCTPGWTGLYCTQRCP 747

Query: 733 ---LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPN--------PCE 781
                +D      C+ G  C  D +   CTC  G  GR CE   P             C 
Sbjct: 748 LGFYGKDCALICQCQNGADC--DHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCL 805

Query: 782 HGGRCESAPGQLPVCSCPQGWQGPRCQQ 809
           +   C+   G    C C  GW+G RC Q
Sbjct: 806 NNSTCDHITG---TCYCSPGWKGARCDQ 830



 Score =  254 bits (648), Expect = 9e-67
 Identities = 245/845 (28%), Positives = 308/845 (36%), Gaps = 207/845 (24%)

Query: 618  EVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE--GGSCVDG 675
            E+ +  CA   C  G C   I    C C+PG+ G         C+S+  G+  G  C   
Sbjct: 103  EMCVPHCADK-CVHGRC---IAPNTCQCEPGWGG-------TNCSSACDGDHWGPHCTS- 150

Query: 676  ENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPG--GFRCV--CEPGWSGPRCSQ 731
                RC C  G+L   C P +          G C+ A G  G+RC   CE G  G  C Q
Sbjct: 151  ----RCQCKNGAL---CNPIT----------GACHCAAGFRGWRCEDRCEQGTYGNDCHQ 193

Query: 732  SLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSP-------CTPN-PCEHG 783
                  C+   C+ G TC  D +   C CPPG  G  CE L P       C    PC++G
Sbjct: 194  R-----CQ---CQNGATC--DHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNG 243

Query: 784  GRCESAPGQLPVCSCPQGWQGPRCQQDVDE------CAGPAPCGPHGICTNLAGSFSCTC 837
            G C    G+   CSCP GW G  C Q   E      C+    C   G C    G   C C
Sbjct: 244  GVCHHVTGE---CSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQ--CHC 298

Query: 838  HGGYTGPSCDQD-------INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC-ARDVD 889
              GYTG  C  +       +   +   C+NGG C    G+  C C  GFAG RC AR   
Sbjct: 299  SPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCP 356

Query: 890  ECLSN-------PCG-PGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPS---------- 931
            E L         PC    T + H  S  C C PG+ G +C +    CSP           
Sbjct: 357  EGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET---CSPGFYGEACQQIC 413

Query: 932  SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLES 991
            SC NG  C D V    C C PG+ G  C        S PC  G        G  C+    
Sbjct: 414  SCQNGADC-DSVTG-KCTCAPGFKGIDC--------STPCPLGTY------GINCS---- 453

Query: 992  FTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRL 1051
                         SR  C+N   C      C C  GW G  C IR   C       G  L
Sbjct: 454  -------------SRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIR---CPSGTWGFGCNL 497

Query: 1052 EQLCQAGGQCVDEDSSHYCV-----------CPEGRTGSHCEQEVDPCLAQPCQHGGTCR 1100
               C  GG C   D +  C            C +G  G +C +  D      C H   C 
Sbjct: 498  TCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCD------CSHADGCH 551

Query: 1101 GYMGGYMCECLPGYNGDNCEDDVDECASQP-------CQHGGSCIDLVARYLCSCPPGTL 1153
               G   C CLPG++G +C+    E    P       C++G SC       +C C PG  
Sbjct: 552  PTTGH--CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDG--ICECAPGFR 607

Query: 1154 GVLCEINEDDCGPG----PPLDSGPRCLHN-GTCVDLVGGFRCTCPPGYTGLRCEADINE 1208
            G  C+     C PG        + P+C+H+ G C  + G   C C PG+TG  C      
Sbjct: 608  GTTCQ---RICSPGFYGHRCSQTCPQCVHSSGPCHHITG--LCDCLPGFTGALCNEVCPS 662

Query: 1209 CR-----SGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQP-------CQ 1256
             R     +G C   +   C         C C+ G+ G  C     P    P       C 
Sbjct: 663  GRFGKNCAGICTCTNNGTCNPIDRS---CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCH 719

Query: 1257 HG-------GQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
            +G       G+C+ +PG   GL  T  C   F+G  C  +       QC  G  C     
Sbjct: 720  NGAFCSAYDGECKCTPG-WTGLYCTQRCPLGFYGKDCALIC------QCQNGADCDHI-- 770

Query: 1310 GPRCACPPGLSGPSCRSFPGSPPGASNASCAA-APCLHGGSCRPAPLAPFFRCACAQGWT 1368
              +C C  G  G  C      P G     C     CL+  +C          C C+ GW 
Sbjct: 771  SGQCTCRTGFMGRHCEQ--KCPSGTYGYGCRQICDCLNNSTCDHITGT----CYCSPGWK 824

Query: 1369 GPRCE 1373
            G RC+
Sbjct: 825  GARCD 829



 Score =  248 bits (633), Expect = 5e-65
 Identities = 240/800 (30%), Positives = 293/800 (36%), Gaps = 208/800 (26%)

Query: 379  CPPGF--TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECL 436
            C PGF  +G  C   V  C   A+ C H GRC+       CQC  G+ G  C +  +   
Sbjct: 94   CCPGFYESGEMC---VPHC---ADKCVH-GRCIAPN---TCQCEPGWGGTNCSSACDGDH 143

Query: 437  SGP-------CRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC----------QSSPCV 479
             GP       C+N A C    G   C C AGF G  CE   D C          Q   C 
Sbjct: 144  WGPHCTSRCQCKNGALCNPITG--ACHCAAGFRGWRCE---DRCEQGTYGNDCHQRCQCQ 198

Query: 480  NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAS----------TPCRNGAKCVDQPDGY 529
            NG  C D V G  C CP G++G+ C+   D C             PC+NG  C       
Sbjct: 199  NGATC-DHVTG-ECRCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG-- 251

Query: 530  ECRCAEGFEGTLCDRNVDD------CSPD-PCHHGRCVDGIASFSCACAPGYTGTRCESQ 582
            EC C  G+ GT+C +   +      CS +  CH+G   D  A+  C C+PGYTG RC+  
Sbjct: 252  ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDA-ATGQCHCSPGYTGERCQ-- 308

Query: 583  VDEC----------RSQPCRHGGKCLDLVDKYLCR------------CPSGTTGVNCEV- 619
             DEC           +  C +GGKC  +    LC             CP G  G+ C+  
Sbjct: 309  -DECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKR 367

Query: 620  ------NIDDC--ASNPCTFGVCRDGINRYDC--VCQPGFTGPLCNVEINECASSPCGEG 669
                  N   C   S  C    C+ G +   C   C PGF G  C      C+   C  G
Sbjct: 368  CPCHLENTHSCHPMSGECA---CKPGWSGLYCNETCSPGFYGEACQ---QICS---CQNG 418

Query: 670  GSCVDGENGFRCLCPPGSLPPLCLPP----------SHPCAHEPCSHGICYDAPGGFRCV 719
              C D   G +C C PG     C  P          S  C  +  +  +C    G   C 
Sbjct: 419  ADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCK--NDAVCSPVDGS--CT 472

Query: 720  CEPGWSGP----RCSQSLARDACE-SQPCRAGGTCSS-DGMGFHCTCPPGVQGRQCELLS 773
            C+ GW G     RC        C  +  C  GG C++ DG    CTC PG +G +CEL  
Sbjct: 473  CKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT---CTCAPGWRGEKCEL-- 527

Query: 774  PCTPNP----------CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDE---------- 813
            PC              C H   C    G    C C  GW G  C     E          
Sbjct: 528  PCQDGTYGLNCAERCDCSHADGCHPTTGH---CRCLPGWSGVHCDSVCAEGRWGPNCSLP 584

Query: 814  --CAGPAPCGPH-GICTNLAGSFSCTCHG----GYTGPSCDQDINDCDPNPCLNGGSCQD 866
              C   A C P  GIC    G    TC      G+ G  C Q    C      + G C  
Sbjct: 585  CYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQC----VHSSGPCHH 640

Query: 867  GVGSFSCSCLPGFAGPRCARDVDECLS-----NPCGPGTCTDHVA----SFTCTCPPGYG 917
              G   C CLPGF G  C    + C S     N  G  TCT++        +C C PG+ 
Sbjct: 641  ITGL--CDCLPGFTGALCN---EVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWI 695

Query: 918  GFHCEQDLPDCS-------PSSCFNGGTC--VDGVNSFSCLCRPGYTGAHCQHEA----- 963
            G  C Q  P            +C NG  C   DG     C C PG+TG +C         
Sbjct: 696  GSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG----ECKCTPGWTGLYCTQRCPLGFY 751

Query: 964  --DPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQT-----LVDWCSRQPCQ--NGGR 1014
              D  L   C +G  C   H   +CTC   F G  C+         +  RQ C   N   
Sbjct: 752  GKDCALICQCQNGADCD--HISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNST 809

Query: 1015 CVQTGAYCLCPPGWSGRLCD 1034
            C      C C PGW G  CD
Sbjct: 810  CDHITGTCYCSPGWKGARCD 829



 Score =  243 bits (619), Expect = 2e-63
 Identities = 232/816 (28%), Positives = 302/816 (37%), Gaps = 216/816 (26%)

Query: 457  CMAGF--TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVD----- 509
            C  GF  +G  C   +  C +  CV+G          +C C  G+ G+ C    D     
Sbjct: 94   CCPGFYESGEMC---VPHC-ADKCVHGRCIAPN----TCQCEPGWGGTNCSSACDGDHWG 145

Query: 510  -ECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVD------DCSPD-PCHHGRCV 560
              C S   C+NGA C   P    C CA GF G  C+   +      DC     C +G   
Sbjct: 146  PHCTSRCQCKNGALC--NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203

Query: 561  DGIASFSCACAPGYTGTRCESQVD------ECRSQ-PCRHGGKCLDLVDKYLCRCPSGTT 613
            D +    C C PGYTG  CE          +C  + PC++GG C  +  +  C CPSG  
Sbjct: 204  DHVTG-ECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWM 260

Query: 614  GVNCEVNIDDCASNPCTFGVCRDGIN-RYDCVCQPGFTGPLCNVEINECASSPCGEGGSC 672
            G  C          PC  G  R G N   +C C  G T   C+    +C  SP   G  C
Sbjct: 261  GTVC--------GQPCPEG--RFGKNCSQECQCHNGGT---CDAATGQCHCSPGYTGERC 307

Query: 673  VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS 732
             D        CP G+   LC   +  C  +  + G CY   G   C+CE G++G RC   
Sbjct: 308  QDE-------CPVGTYGVLC---AETC--QCVNGGKCYHVSGA--CLCEAGFAGERCEAR 353

Query: 733  LARDA-----CESQ-PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPN-------- 778
            L  +      C+ + PC    T S   M   C C PG  G  C     C+P         
Sbjct: 354  LCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCN--ETCSPGFYGEACQQ 411

Query: 779  --PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI-CTNLAG---- 831
               C++G  C+S  G+   C+C  G++G        +C+ P P G +GI C++  G    
Sbjct: 412  ICSCQNGADCDSVTGK---CTCAPGFKGI-------DCSTPCPLGTYGINCSSRCGCKND 461

Query: 832  ------SFSCTCHGGYTGPSCDQDIND------CDPN-PCLNGGSCQDGVGSFSCSCLPG 878
                    SCTC  G+ G  C            C+    CLNGG+C    G+  C+C PG
Sbjct: 462  AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPG 519

Query: 879  FAGPRCARDVDECLSNPCGPGT----CTD----------HVASFTCTCPPGYGGFHCEQD 924
            + G +C          PC  GT    C +          H  +  C C PG+ G HC+  
Sbjct: 520  WRGEKCEL--------PCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSV 571

Query: 925  L------PDCS-PSSCFNGGTC---------VDGVNSFSC--LCRPGYTGAHCQHEADPC 966
                   P+CS P  C NG +C           G    +C  +C PG+ G  C      C
Sbjct: 572  CAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQC 631

Query: 967  L--SRPCLH------------GGVCSAAHPGFR--------CTCLESFT----GPQCQTL 1000
            +  S PC H            G +C+   P  R        CTC  + T       CQ  
Sbjct: 632  VHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCY 691

Query: 1001 VDW----CSRQPC---------------QNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCR 1041
              W    CS QPC                NG  C      C C PGW+G  C  R   C 
Sbjct: 692  PGWIGSDCS-QPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQR---CP 747

Query: 1042 EAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRG 1101
                     L   CQ G  C  +  S  C C  G  G HCEQ+        C  G    G
Sbjct: 748  LGFYGKDCALICQCQNGADC--DHISGQCTCRTGFMGRHCEQK--------CPSG--TYG 795

Query: 1102 YMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSC 1137
            Y    +C+CL   N   C+     C   P   G  C
Sbjct: 796  YGCRQICDCL---NNSTCDHITGTCYCSPGWKGARC 828



 Score =  207 bits (527), Expect = 1e-52
 Identities = 197/704 (27%), Positives = 240/704 (34%), Gaps = 219/704 (31%)

Query: 37  GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPC----HSGPCAGRGV 92
           G     C     C NG  C  +      C CPPG+ G  C  ED C    H   C  R  
Sbjct: 185 GTYGNDCHQRCQCQNGATCDHVTGE---CRCPPGYTGAFC--EDLCPPGKHGPQCEQRCP 239

Query: 93  CQSSVVAGTARFSCRCPRGFRGPDCSLPDP--------CLSSPCAHGARCSVGPDGRFLC 144
           CQ+  V       C CP G+ G  C  P P             C +G  C         C
Sbjct: 240 CQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATG---QC 296

Query: 145 SCPPGYQGRSCRSDVDECRVGE---------PCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
            C PGY G  C+   DEC VG           C +GG C +  G+  C C AG+ G  CE
Sbjct: 297 HCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCE 351

Query: 196 NPAVP----------------------------CAPSP---------------------- 205
               P                            CA  P                      
Sbjct: 352 ARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQ 411

Query: 206 ---CRNGGTCRQSGDLTYDCACLPGFEGQNCE---------VNVDDCPGHRCLNGGTC-- 251
              C+NG  C     +T  C C PGF+G +C          +N     G  C N   C  
Sbjct: 412 ICSCQNGADC---DSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCG--CKNDAVCSP 466

Query: 252 VDGVNTYNCQCPPEWTGQFCTEDVDE------CQLQPNACHNGGTCFNTLGGHSCVCVNG 305
           VDG    +C C   W G  C+           C L    C NGG C NTL G +C C  G
Sbjct: 467 VDG----SCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQ-CLNGGAC-NTLDG-TCTCAPG 519

Query: 306 WTGESCSQNIDD------CATAV-CFHGATCHDRVASFYCACPMGKTGLLCHLDDACV-- 356
           W GE C     D      CA    C H   CH      +C C  G +G+  H D  C   
Sbjct: 520 WRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG--HCRCLPGWSGV--HCDSVCAEG 575

Query: 357 ------SNPCH---------EDAICDTNPVNGRAIC--TCPPGFTGGACDQDVDECSIGA 399
                 S PC+         +D IC+  P      C   C PGF G  C Q   +C   +
Sbjct: 576 RWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSS 635

Query: 400 NPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG----------PCRNQATC--L 447
            PC H+        + LC C  G+TG  C      C SG           C N  TC  +
Sbjct: 636 GPCHHI--------TGLCDCLPGFTGALCN---EVCPSGRFGKNCAGICTCTNNGTCNPI 684

Query: 448 DRIGQFTCICMAGFTGTYCEVDIDECQSSP-------CVNGGVCKDRVNGFSCT------ 494
           DR    +C C  G+ G+ C          P       C NG  C        CT      
Sbjct: 685 DR----SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGL 740

Query: 495 -----CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCD------ 543
                CP GF G  C L         C+NGA C D   G +C C  GF G  C+      
Sbjct: 741 YCTQRCPLGFYGKDCAL------ICQCQNGADC-DHISG-QCTCRTGFMGRHCEQKCPSG 792

Query: 544 ------RNVDDC-SPDPCHHGRCVDGIASFSCACAPGYTGTRCE 580
                 R + DC +   C H        + +C C+PG+ G RC+
Sbjct: 793 TYGYGCRQICDCLNNSTCDH-------ITGTCYCSPGWKGARCD 829



 Score =  199 bits (507), Expect = 2e-50
 Identities = 199/734 (27%), Positives = 252/734 (34%), Gaps = 226/734 (30%)

Query: 875  CLPGF--AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL------P 926
            C PGF  +G  C   V  C ++ C  G C   +A  TC C PG+GG +C          P
Sbjct: 94   CCPGFYESGEMC---VPHC-ADKCVHGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGP 146

Query: 927  DC-SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP------CLSR-PCLHGGVCS 978
             C S   C NG  C     + +C C  G+ G  C+   +       C  R  C +G  C 
Sbjct: 147  HCTSRCQCKNGALC--NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCD 204

Query: 979  AAHPGFRCTCLESFTGPQCQTLVD------WCSRQ-PCQNGGRCVQTGAYCLCPPGWSGR 1031
              H    C C   +TG  C+ L         C ++ PCQNGG C      C CP GW G 
Sbjct: 205  --HVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGT 262

Query: 1032 LCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQ 1091
            +C     PC                                PEGR G +C QE       
Sbjct: 263  VC---GQPC--------------------------------PEGRFGKNCSQECQ----- 282

Query: 1092 PCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPG 1151
             C +GGTC    G   C C PGY G+ C+D+                         CP G
Sbjct: 283  -CHNGGTCDAATG--QCHCSPGYTGERCQDE-------------------------CPVG 314

Query: 1152 TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRS 1211
            T GVLC    + C          +C++ G C  + G   C C  G+ G RCEA +  C  
Sbjct: 315  TYGVLC---AETC----------QCVNGGKCYHVSGA--CLCEAGFAGERCEARL--CPE 357

Query: 1212 G----------ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP------CES-QP 1254
            G           CH  +T  C    G    C C  G+SG  C    SP      C+    
Sbjct: 358  GLYGIKCDKRCPCHLENTHSCHPMSG---ECACKPGWSGLYCNETCSPGFYGEACQQICS 414

Query: 1255 CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPV---GVPCQQ----- 1306
            CQ+G  C         +T  C CA  F G  C           CP+   G+ C       
Sbjct: 415  CQNGADC-------DSVTGKCTCAPGFKGIDC--------STPCPLGTYGINCSSRCGCK 459

Query: 1307 -----TPRGPRCACPPGLSGPSCRSFPGSPPGASNASC-AAAPCLHGGSCRPAPLAPFFR 1360
                 +P    C C  G  G  C      P G     C     CL+GG+C          
Sbjct: 460  NDAVCSPVDGSCTCKAGWHGVDCSI--RCPSGTWGFGCNLTCQCLNGGACNTLD----GT 513

Query: 1361 CACAQGWTGPRCEAPAA----APEVSEEPRCPRA-ACQAKRGDQR---------CDREC- 1405
            C CA GW G +CE P          +E   C  A  C    G  R         CD  C 
Sbjct: 514  CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCA 573

Query: 1406 ---------------NSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPA 1450
                           N   C  D G C  + G     C+ + C   F   RC   C  P 
Sbjct: 574  EGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRI-CSPGFYGHRCSQTC--PQ 630

Query: 1451 CLYDNFDCH---------AGGRERTCNPV-----YEKYCADHFA---DGRCDQGCNTEEC 1493
            C++ +  CH          G     CN V     + K CA       +G C+    + +C
Sbjct: 631  CVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQC 690

Query: 1494 --GWDGLDCASEVP 1505
              GW G DC+   P
Sbjct: 691  YPGWIGSDCSQPCP 704



 Score =  120 bits (302), Expect = 1e-26
 Identities = 123/450 (27%), Positives = 167/450 (37%), Gaps = 106/450 (23%)

Query: 1109 ECLPGY--NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGP 1166
            +C PG+  +G+ C   V  CA + C HG  CI   A   C C PG  G  C    D    
Sbjct: 93   QCCPGFYESGEMC---VPHCADK-CVHG-RCI---APNTCQCEPGWGGTNCSSACDGDHW 144

Query: 1167 GPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGA--------CHAAH 1218
            GP   S  +C +   C  + G   C C  G+ G RCE   + C  G         C   +
Sbjct: 145  GPHCTSRCQCKNGALCNPITGA--CHCAAGFRGWRCE---DRCEQGTYGNDCHQRCQCQN 199

Query: 1219 TRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP------CESQ-PCQHGGQCRPSPGPGGGL 1271
               C    G    C C  G++G  C+ +  P      CE + PCQ+GG C    G     
Sbjct: 200  GATCDHVTG---ECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGE---- 252

Query: 1272 TFTCHCAQPFWGPRCE------RVARSC-RELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324
               C C   + G  C       R  ++C +E QC  G  C       +C C PG +G  C
Sbjct: 253  ---CSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATG--QCHCSPGYTGERC 307

Query: 1325 RSFPGSPPGASNASCA-AAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEA---PAAAPE 1380
            +     P G     CA    C++GG C     A    C C  G+ G RCEA   P     
Sbjct: 308  QD--ECPVGTYGVLCAETCQCVNGGKCYHVSGA----CLCEAGFAGERCEARLCPEGLYG 361

Query: 1381 VSEEPRCP-----RAACQAKRGDQRCDRECNSPGCGWDGGDCS--LSVGDPWRQCEAL-- 1431
            +  + RCP       +C    G+  C         GW G  C+   S G     C+ +  
Sbjct: 362  IKCDKRCPCHLENTHSCHPMSGECACKP-------GWSGLYCNETCSPGFYGEACQQICS 414

Query: 1432 -----QCWRLFNNSRCDPA-----CSSPACLYDNFDCHAGGR-----ERTCNPVYEKYCA 1476
                  C  +     C P      CS+P C    +  +   R     +  C+PV      
Sbjct: 415  CQNGADCDSVTGKCTCAPGFKGIDCSTP-CPLGTYGINCSSRCGCKNDAVCSPV------ 467

Query: 1477 DHFADGRCDQGCNTEECGWDGLDCASEVPA 1506
                DG C     T + GW G+DC+   P+
Sbjct: 468  ----DGSC-----TCKAGWHGVDCSIRCPS 488


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  279 bits (713), Expect = 3e-74
 Identities = 255/876 (29%), Positives = 311/876 (35%), Gaps = 241/876 (27%)

Query: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
           CP  +   D  +P    +  C HG RC V PD    C C PG+ G  C S  D    G  
Sbjct: 89  CPGYYESGDFCIP--LCTEECVHG-RC-VSPD---TCHCEPGWGGPDCSSGCDSDHWGPH 141

Query: 168 CRHGGTCLN----TPGSFRCQCPAGYTGPLCENPAVP------C-APSPCRNGGTCRQSG 216
           C +   C N     P +  C C AG+ G  CE    P      C  P  CR+G +C    
Sbjct: 142 CSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRA 201

Query: 217 DLTYDCACLPGFEGQNCEVNVDDCP--GH--------RCLNGGTCVDGVNTYNCQCPPEW 266
               +C C PG+ G  CE   + CP   H         C NGGTC     T  C CPP W
Sbjct: 202 G---ECLCAPGYTGVYCE---ELCPPGSHGAHCELRCPCQNGGTCHH--ITGECACPPGW 253

Query: 267 TGQFCTEDVDECQLQPNA-----CHNGGTCFNTLGGHSCVCVNGWTGESCSQNID----- 316
           TG  C +         N      CH+GG C +  G   C C  G+ G+ C +        
Sbjct: 254 TGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTG--QCHCTAGYMGDRCQEECPFGSFG 311

Query: 317 -DCAT-AVCFHGATCHDRVASFYCACPMGKTGLLC---------HLDDACVSNPCHEDAI 365
             C+    C +G  C     +  C C  G  G  C         H     +  PC  D  
Sbjct: 312 FQCSQHCDCHNGGQCSPTTGA--CECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNT 369

Query: 366 CDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTG 425
              +PV G   CTC PG++G  C++                            C  GY G
Sbjct: 370 ISCHPVTG--ACTCQPGWSGHHCNE---------------------------SCPVGYYG 400

Query: 426 PRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDI------DECQS-SPC 478
             C+      L   C+N A C    G   C C  GF G  C V          C S   C
Sbjct: 401 DGCQ------LPCTCQNGADCHSITG--GCTCAPGFMGEVCAVSCAAGTYGPNCSSICSC 452

Query: 479 VNGGVCKDRVNGFSCTCPSGFSGSTCQLDVD------EC-ASTPCRNGAKCVDQPDGYEC 531
            NGG C   V+G SCTC  G+ G  C L          C  S  C NGA C   P    C
Sbjct: 453 NNGGTCSP-VDG-SCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAAC--SPIDGSC 508

Query: 532 RCAEGFEGTLCDRNVDD------CSPD-PCHHGRCVDGIASFSCACAPGYTGTRCESQVD 584
            C  G+ G  C+    D      CS    C H    D +    C C  G+TG RC+S   
Sbjct: 509 SCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTG-HCCCLAGWTGIRCDS--- 564

Query: 585 ECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCV 644
                                  CP G  G NC V+        C+     DG     C 
Sbjct: 565 ----------------------TCPPGRWGPNCSVSCSCENGGSCS---PEDG----SCE 595

Query: 645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAH--E 702
           C PGF GPLC                         + +CPPG     C  P   C H   
Sbjct: 596 CAPGFRGPLC-------------------------QRICPPGFYGHGCAQPCPLCVHSSR 630

Query: 703 PCSH--GICYDAPGGFRCVCEPGWSGPRCSQSLA-----RDACESQPCRAGGTCSS-DGM 754
           PC H  GI         C C PG+SG  C+Q  A     +D  +   C   GTCS  DG 
Sbjct: 631 PCHHISGI---------CECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDG- 680

Query: 755 GFHCTCPPGVQGRQCELLSPCTPN----------PCEHGGRCESAPGQLPVCSCPQGWQG 804
              C C PG  G+ C     C P            C +G  C +  G    C C  GW G
Sbjct: 681 --SCQCFPGWIGKDCS--QACPPGFWGPACFHACSCHNGASCSAEDG---ACHCTPGWTG 733

Query: 805 PRCQQDV------DECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN-- 856
             C Q         +C     C     C +++G   CTC  G+TG  C+Q    C P   
Sbjct: 734 LFCTQRCPAAFFGKDCGRVCQCQNGASCDHISG--KCTCRTGFTGQHCEQ---RCAPGTF 788

Query: 857 --------PCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
                    C+N  +C    G  +C C PGF G RC
Sbjct: 789 GYGCQQLCECMNNSTCDHVTG--TCYCSPGFKGIRC 822



 Score =  267 bits (683), Expect = 8e-71
 Identities = 252/831 (30%), Positives = 326/831 (39%), Gaps = 190/831 (22%)

Query: 570  CAPGY--TGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
            C PGY  +G  C   +  C ++ C HG +C   V    C C  G  G +C    D     
Sbjct: 88   CCPGYYESGDFC---IPLC-TEECVHG-RC---VSPDTCHCEPGWGGPDCSSGCDSDHWG 139

Query: 628  P-CTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC--LCP 684
            P C+        NR  C CQ    G LCN     C          C  G  G+RC  LC 
Sbjct: 140  PHCS--------NR--CQCQ---NGALCNPITGACV---------CAAGFRGWRCEELCA 177

Query: 685  PGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDA----CES 740
            PG+    C  P        C HG   D   G  C+C PG++G  C +     +    CE 
Sbjct: 178  PGTHGKGCQLPCQ------CRHGASCDPRAG-ECLCAPGYTGVYCEELCPPGSHGAHCEL 230

Query: 741  Q-PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPN----------PCEHGGRCESA 789
            + PC+ GGTC    +   C CPPG  G  C    PC P           PC HGG+C+  
Sbjct: 231  RCPCQNGGTCHH--ITGECACPPGWTGAVCA--QPCPPGTFGQNCSQDCPCHHGGQCDHV 286

Query: 790  PGQLPVCSCPQGWQGPRCQQDVD------ECAGPAPCGPHGICTNLAGSFSCTCHGGYTG 843
             GQ   C C  G+ G RCQ++        +C+    C   G C+   G+  C C  GY G
Sbjct: 287  TGQ---CHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGA--CECEPGYKG 341

Query: 844  PSCDQDI-------NDCD-PNPCL--NGGSCQDGVGSFSCSCLPGFAGPRCARDV----- 888
            P C + +         C  P PC   N  SC    G+  C+C PG++G  C         
Sbjct: 342  PRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGA--CTCQPGWSGHHCNESCPVGYY 399

Query: 889  -DECLSNPCGPGTCTD----HVASFTCTCPPGYGGFHCEQDL------PDCSP-SSCFNG 936
             D C   PC   TC +    H  +  CTC PG+ G  C          P+CS   SC NG
Sbjct: 400  GDGC-QLPC---TCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNG 455

Query: 937  GTC--VDGVNSFSCLCRPGYTGAHCQHEADPCLSRP----------CLHGGVCSAAHPGF 984
            GTC  VDG    SC C+ G+ G  C     PC S            C +G  CS      
Sbjct: 456  GTCSPVDG----SCTCKEGWQGLDCTL---PCPSGTWGLNCNESCTCANGAACSPIDGS- 507

Query: 985  RCTCLESFTGPQCQ------TLVDWCSRQ-PCQNGGRCVQTGAYCLCPPGWSGRLCDIRS 1037
             C+C   + G  C+      T    CS    C +   C     +C C  GW+G  CD   
Sbjct: 508  -CSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTC 566

Query: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC-----------VCPEGRTGSHCEQEVD 1086
             P R         +   C+ GG C  ED S  C           +CP G  G  C Q   
Sbjct: 567  PPGRWGP---NCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCP 623

Query: 1087 PCL--AQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV------DECASQ-PCQHGGSC 1137
             C+  ++PC H       + G +CECLPG++G  C           +CA    C + G+C
Sbjct: 624  LCVHSSRPCHH-------ISG-ICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTC 675

Query: 1138 IDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLH-----NGTCVDLVGGFRCT 1192
              +     C C PG +G  C      C PG     GP C H     NG       G  C 
Sbjct: 676  SPIDGS--CQCFPGWIGKDCS---QACPPG---FWGPACFHACSCHNGASCSAEDG-ACH 726

Query: 1193 CPPGYTGL----RCEADI--NECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV 1246
            C PG+TGL    RC A     +C    C   +   C    G   +C C  GF+G  C+  
Sbjct: 727  CTPGWTGLFCTQRCPAAFFGKDC-GRVCQCQNGASCDHISG---KCTCRTGFTGQHCEQR 782

Query: 1247 LSPCE-SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCREL 1296
             +P      CQ   +C  +      +T TC+C+  F G RC++ A    EL
Sbjct: 783  CAPGTFGYGCQQLCECMNN-STCDHVTGTCYCSPGFKGIRCDQAALMMEEL 832



 Score =  266 bits (680), Expect = 2e-70
 Identities = 249/856 (29%), Positives = 312/856 (36%), Gaps = 229/856 (26%)

Query: 457  CMAGF--TGTYC-EVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE--- 510
            C  G+  +G +C  +  +EC    CV+   C          C  G+ G  C    D    
Sbjct: 88   CCPGYYESGDFCIPLCTEECVHGRCVSPDTCH---------CEPGWGGPDCSSGCDSDHW 138

Query: 511  ---CAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCDR------NVDDCS-PDPCHHGRC 559
               C++   C+NGA C   P    C CA GF G  C+       +   C  P  C HG  
Sbjct: 139  GPHCSNRCQCQNGALC--NPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGAS 196

Query: 560  VDGIASFSCACAPGYTGTRCE------SQVDECRSQ-PCRHGGKCLDLVDKYLCRCPSGT 612
             D  A   C CAPGYTG  CE      S    C  + PC++GG C  +  +  C CP G 
Sbjct: 197  CDPRAG-ECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGE--CACPPGW 253

Query: 613  TGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSC 672
            TG  C        + PC  G      ++ DC C  G     C+    +C          C
Sbjct: 254  TGAVC--------AQPCPPGTFGQNCSQ-DCPCHHGGQ---CDHVTGQC---------HC 292

Query: 673  VDGENGFRCL--CPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRC 729
              G  G RC   CP GS    C        H  C +G  C    G   C CEPG+ GPRC
Sbjct: 293  TAGYMGDRCQEECPFGSFGFQC------SQHCDCHNGGQCSPTTGA--CECEPGYKGPRC 344

Query: 730  SQSLARDACESQ------PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC-------- 775
             + L  +           PC A  T S   +   CTC PG  G  C    P         
Sbjct: 345  QERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQ 404

Query: 776  TPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDV------DECAGPAPCGPHGICTNL 829
             P  C++G  C S  G    C+C  G+ G  C            C+    C   G C+ +
Sbjct: 405  LPCTCQNGADCHSITGG---CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPV 461

Query: 830  AGSFSCTCHGGYTG-------PSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGP 882
             G  SCTC  G+ G       PS    +N  +   C NG +C    G  SCSC PG+ G 
Sbjct: 462  DG--SCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDG--SCSCTPGWLGD 517

Query: 883  RCARDVDECLSNPCGPGT----CTDHV----------ASFTCTCPPGYGGFHCEQDL--- 925
             C          PC  GT    C++H            +  C C  G+ G  C+      
Sbjct: 518  TC--------ELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPG 569

Query: 926  ---PDCSPS-SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE----------ADPC----- 966
               P+CS S SC NGG+C       SC C PG+ G  CQ            A PC     
Sbjct: 570  RWGPNCSVSCSCENGGSC--SPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVH 627

Query: 967  LSRPCLH-GGVCSAAHPGF-----RCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA 1020
             SRPC H  G+C    PGF        C   + G  C  L   CS   C N G C     
Sbjct: 628  SSRPCHHISGICECL-PGFSGALCNQVCAGGYFGQDCAQL---CS---CANNGTCSPIDG 680

Query: 1021 YCLCPPGWSGRLCDIRSLP------CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPE 1074
             C C PGW G+ C     P      C  A +         C  G  C  ED +  C C  
Sbjct: 681  SCQCFPGWIGKDCSQACPPGFWGPACFHACS---------CHNGASCSAEDGA--CHCTP 729

Query: 1075 GRTGSHCEQEV-------DPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECA 1127
            G TG  C Q         D      CQ+G +C    G   C C  G+ G +CE       
Sbjct: 730  GWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISG--KCTCRTGFTGQHCEQ------ 781

Query: 1128 SQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVG 1187
                                C PGT G  C   +  C           C++N TC  + G
Sbjct: 782  -------------------RCAPGTFGYGC---QQLC----------ECMNNSTCDHVTG 809

Query: 1188 GFRCTCPPGYTGLRCE 1203
               C C PG+ G+RC+
Sbjct: 810  --TCYCSPGFKGIRCD 823



 Score =  261 bits (666), Expect = 7e-69
 Identities = 242/850 (28%), Positives = 308/850 (36%), Gaps = 228/850 (26%)

Query: 53  GRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGP-CAGRGVCQSSVVAGTARFSCRCPR 110
           GRC    +    C C PGW G  C    D  H GP C+ R  CQ+  +      +C C  
Sbjct: 110 GRCVSPDT----CHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAA 165

Query: 111 GFRGPDCSLPDPC----------LSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR---- 156
           GFRG  C   + C          L   C HGA C         C C PGY G  C     
Sbjct: 166 GFRGWRCE--ELCAPGTHGKGCQLPCQCRHGASCDPRAGE---CLCAPGYTGVYCEELCP 220

Query: 157 --SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP------CAPS-PCR 207
             S    C +  PC++GGTC +  G   C CP G+TG +C  P  P      C+   PC 
Sbjct: 221 PGSHGAHCELRCPCQNGGTCHHITG--ECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCH 278

Query: 208 NGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP----GHRCL------NGGTCVDGVNT 257
           +GG C     +T  C C  G+ G  C+   ++CP    G +C       NGG C     T
Sbjct: 279 HGGQC---DHVTGQCHCTAGYMGDRCQ---EECPFGSFGFQCSQHCDCHNGGQC--SPTT 330

Query: 258 YNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCF-------NTLGGH----SCVCVNGW 306
             C+C P + G  C E     +L P   H  G          NT+  H    +C C  GW
Sbjct: 331 GACECEPGYKGPRCQE-----RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGW 385

Query: 307 TGESCSQNI------DDC-ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP 359
           +G  C+++       D C     C +GA CH       C C  G  G +C +  A  +  
Sbjct: 386 SGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYG 443

Query: 360 CHEDAICDTN------PVNGRAICTCPPGFTGGACDQDVDECSIGAN-----PCEHLGRC 408
            +  +IC  N      PV+G   CTC  G+ G  C       + G N      C +   C
Sbjct: 444 PNCSSICSCNNGGTCSPVDGS--CTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAAC 501

Query: 409 VNTQGSFLCQCGRGYTGPRCETDVNECLSG-PCRNQATCLDRIG----QFTCICMAGFTG 463
               GS  C C  G+ G  CE    +   G  C     C    G       C C+AG+TG
Sbjct: 502 SPIDGS--CSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTG 559

Query: 464 TYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCV 523
             C+                          TCP G  G  C +      S  C NG  C 
Sbjct: 560 IRCD-------------------------STCPPGRWGPNCSV------SCSCENGGSC- 587

Query: 524 DQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQV 583
             P+   C CA GF G LC R                         C PG+ G  C    
Sbjct: 588 -SPEDGSCECAPGFRGPLCQR------------------------ICPPGFYGHGCAQPC 622

Query: 584 DEC--RSQPCRHGG---KCLDLVDKYLCR--CPSGTTGVNCEVNIDDCASNPCTFGVCR- 635
             C   S+PC H     +CL      LC   C  G  G +C   +  CA+N    G C  
Sbjct: 623 PLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDC-AQLCSCANN----GTCSP 677

Query: 636 -DGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP 694
            DG     C C PG+ G  C        S  C                 PPG   P C  
Sbjct: 678 IDG----SCQCFPGWIGKDC--------SQAC-----------------PPGFWGPACF- 707

Query: 695 PSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS-----LARDACESQPCRAGGTC 749
             H C+   C +G    A  G  C C PGW+G  C+Q        +D      C+ G +C
Sbjct: 708 --HACS---CHNGASCSAEDG-ACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASC 761

Query: 750 SSDGMGFHCTCPPGVQGRQCELLSPCTPN----------PCEHGGRCESAPGQLPVCSCP 799
             D +   CTC  G  G+ CE    C P            C +   C+   G    C C 
Sbjct: 762 --DHISGKCTCRTGFTGQHCE--QRCAPGTFGYGCQQLCECMNNSTCDHVTG---TCYCS 814

Query: 800 QGWQGPRCQQ 809
            G++G RC Q
Sbjct: 815 PGFKGIRCDQ 824



 Score =  240 bits (612), Expect = 1e-62
 Identities = 236/817 (28%), Positives = 296/817 (36%), Gaps = 226/817 (27%)

Query: 379  CPPGF--TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECL 436
            C PG+  +G  C   +  C+     C H GRCV+      C C  G+ GP C +  +   
Sbjct: 88   CCPGYYESGDFC---IPLCT---EECVH-GRCVSPD---TCHCEPGWGGPDCSSGCDSDH 137

Query: 437  SGP-------CRNQATCLDRIGQFTCICMAGFTGTYCE------VDIDECQ-SSPCVNGG 482
             GP       C+N A C    G   C+C AGF G  CE           CQ    C +G 
Sbjct: 138  WGPHCSNRCQCQNGALCNPITG--ACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGA 195

Query: 483  VCKDRVNGFSCT-----------CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYEC 531
             C  R     C            CP G  G+ C+L        PC+NG  C       EC
Sbjct: 196  SCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCEL------RCPCQNGGTCHHITG--EC 247

Query: 532  RCAEGFEGTLCDRNV------DDCSPD-PCHHGRCVDGIASFSCACAPGYTGTRCESQVD 584
             C  G+ G +C +         +CS D PCHHG   D +    C C  GY G RC+ +  
Sbjct: 248  ACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTG-QCHCTAGYMGDRCQEECP 306

Query: 585  ------ECRSQ-PCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDG 637
                  +C     C +GG+C        C C  G  G  C+  +            C +G
Sbjct: 307  FGSFGFQCSQHCDCHNGGQCSPTTGA--CECEPGYKGPRCQERL------------CPEG 352

Query: 638  INRYDCVCQPGFTGPL-CNVEINECASSPCGEGGSCVDGENGFRC--LCPPGSLPPLCLP 694
            ++       PG T P  C+ + N  +  P     +C  G +G  C   CP G     C  
Sbjct: 353  LHG------PGCTLPCPCDAD-NTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGC-- 403

Query: 695  PSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRCSQSLARDA----CESQ-PCRAGGT 748
               PC    C +G  C+   GG  C C PG+ G  C+ S A       C S   C  GGT
Sbjct: 404  -QLPCT---CQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGT 457

Query: 749  CSS-DGMGFHCTCPPGVQGRQCELLSP-----------CTPNPCEHGGRCESAPGQLPVC 796
            CS  DG    CTC  G QG  C L  P           CT   C +G  C    G    C
Sbjct: 458  CSPVDGS---CTCKEGWQGLDCTLPCPSGTWGLNCNESCT---CANGAACSPIDGS---C 508

Query: 797  SCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAG----SFSCTCHGGYTGPSCDQDIND 852
            SC  GW G  C+    +      C  H  C++  G    +  C C  G+TG  CD   + 
Sbjct: 509  SCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCD---ST 565

Query: 853  CDPN----------PCLNGGSCQDGVGSFSCS-----------CLPGFAGPRCARDVDEC 891
            C P            C NGGSC    GS  C+           C PGF G  CA+    C
Sbjct: 566  CPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLC 625

Query: 892  L--SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP------DCSP-SSCFNGGTC--V 940
            +  S PC       H  S  C C PG+ G  C Q         DC+   SC N GTC  +
Sbjct: 626  VHSSRPC-------HHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPI 678

Query: 941  DGVNSFSCLCRPGYTGAHCQHEADPCLSRP-------CLHGGVCSAAH------PGF--- 984
            DG    SC C PG+ G  C     P    P       C +G  CSA        PG+   
Sbjct: 679  DG----SCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGL 734

Query: 985  --------------------------------RCTCLESFTGPQCQ------TLVDWCSR 1006
                                            +CTC   FTG  C+      T    C +
Sbjct: 735  FCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQ 794

Query: 1007 Q-PCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCRE 1042
               C N   C      C C PG+ G  CD  +L   E
Sbjct: 795  LCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEE 831



 Score =  229 bits (585), Expect = 2e-59
 Identities = 229/826 (27%), Positives = 286/826 (34%), Gaps = 212/826 (25%)

Query: 760  CPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDE------ 813
            C PG        +  CT   C HG RC S       C C  GW GP C    D       
Sbjct: 88   CCPGYYESGDFCIPLCTEE-CVHG-RCVSPD----TCHCEPGWGGPDCSSGCDSDHWGPH 141

Query: 814  CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI------NDCD-PNPCLNGGSCQD 866
            C+    C    +C  + G+  C C  G+ G  C++          C  P  C +G SC  
Sbjct: 142  CSNRCQCQNGALCNPITGA--CVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDP 199

Query: 867  GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP 926
              G   C C PG+ G  C                           CPPG  G HCE   P
Sbjct: 200  RAGE--CLCAPGYTGVYCEE------------------------LCPPGSHGAHCELRCP 233

Query: 927  DCSPSSCFNGGTC--VDGVNSFSCLCRPGYTGAHCQHEADP-------CLSRPCLHGGVC 977
                  C NGGTC  + G     C C PG+TGA C     P           PC HGG C
Sbjct: 234  ------CQNGGTCHHITG----ECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC 283

Query: 978  SAAHPGFRCTCLESFTGPQCQTLVDW------CSRQ-PCQNGGRCVQTGAYCLCPPGWSG 1030
               H   +C C   + G +CQ    +      CS+   C NGG+C  T   C C PG+ G
Sbjct: 284  D--HVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKG 341

Query: 1031 RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV----- 1085
              C  R   C E     G  L   C A         +  C C  G +G HC +       
Sbjct: 342  PRCQERL--CPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYY 399

Query: 1086 -DPC-LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV------DECASQ-PCQHGGS 1136
             D C L   CQ+G  C    GG  C C PG+ G+ C            C+S   C +GG+
Sbjct: 400  GDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGT 457

Query: 1137 CIDLVARYLC-----------------------------------------SCPPGTLGV 1155
            C  +     C                                         SC PG LG 
Sbjct: 458  CSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGD 517

Query: 1156 LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSG--- 1212
             CE+   D   G        C H   C  + G   C C  G+TG+RC++     R G   
Sbjct: 518  TCELPCPDGTFGLNCSEHCDCSHADGCDPVTG--HCCCLAGWTGIRCDSTCPPGRWGPNC 575

Query: 1213 --ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVL----------SPC-----ESQPC 1255
              +C   +   C  + G    C C  GF GP CQ +            PC      S+PC
Sbjct: 576  SVSCSCENGGSCSPEDGS---CECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPC 632

Query: 1256 QH-GGQCRPSPGPGGGLTFTCH--CAQPFWGPRCERVARSCRELQC-PVGVPCQQTPR-- 1309
             H  G C   PG  G L   C+  CA  ++G  C ++        C P+   CQ  P   
Sbjct: 633  HHISGICECLPGFSGAL---CNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWI 689

Query: 1310 GPRC--ACPPGLSGPSC----RSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFF---- 1359
            G  C  ACPPG  GP+C        G+   A + +C   P   G  C     A FF    
Sbjct: 690  GKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDC 749

Query: 1360 -----------------RCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCD 1402
                             +C C  G+TG  CE   A       P      CQ     Q C 
Sbjct: 750  GRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCA-------PGTFGYGCQ-----QLC- 796

Query: 1403 REC-NSPGCGWDGGDCSLSVGDPWRQCE--ALQCWRLFNNSRCDPA 1445
             EC N+  C    G C  S G    +C+  AL    L   ++  PA
Sbjct: 797  -ECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPA 841



 Score =  213 bits (542), Expect = 2e-54
 Identities = 205/706 (29%), Positives = 251/706 (35%), Gaps = 183/706 (25%)

Query: 33  LAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVG-------------ERCQLE 79
           L  PG+    C    PC NGG C  +      C CPPGW G             + C  +
Sbjct: 218 LCPPGSHGAHCELRCPCQNGGTCHHITGE---CACPPGWTGAVCAQPCPPGTFGQNCSQD 274

Query: 80  DPCHSGPCAGRGVCQSSVVAGTARFSCR--CPRGFRGPDCSLPDPCLSSPCAHGARCSVG 137
            PCH G        Q    AG     C+  CP G  G  CS         C +G +CS  
Sbjct: 275 CPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQ-----HCDCHNGGQCSPT 329

Query: 138 PDGRFLCSCPPGYQGRSCRSDV-------DECRVGEPCRHGGT--CLNTPGSFRCQ---- 184
                 C C PGY+G  C+  +         C +  PC    T  C    G+  CQ    
Sbjct: 330 TGA---CECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWS 386

Query: 185 -------CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNV 237
                  CP GY G  C+   +PC    C+NG  C     +T  C C PGF G+ C V+ 
Sbjct: 387 GHHCNESCPVGYYGDGCQ---LPCT---CQNGADCHS---ITGGCTCAPGFMGEVCAVSC 437

Query: 238 ------DDCPGH-RCLNGGTC--VDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA---- 284
                  +C     C NGGTC  VDG    +C C   W G  CT          N     
Sbjct: 438 AAGTYGPNCSSICSCNNGGTCSPVDG----SCTCKEGWQGLDCTLPCPSGTWGLNCNESC 493

Query: 285 -CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV-------CFHGATCHDRVASF 336
            C NG  C    G  SC C  GW G++C     D    +       C H   C D V   
Sbjct: 494 TCANGAACSPIDG--SCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGC-DPVTG- 549

Query: 337 YCACPMGKTGLLCHLDDAC----------VSNPCH-------EDAICDTNPVNGRAICT- 378
           +C C  G TG+ C  D  C          VS  C        ED  C+  P     +C  
Sbjct: 550 HCCCLAGWTGIRC--DSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQR 607

Query: 379 -CPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLS 437
            CPPGF G  C Q    C   + PC H+        S +C+C  G++G  C         
Sbjct: 608 ICPPGFYGHGCAQPCPLCVHSSRPCHHI--------SGICECLPGFSGALC--------- 650

Query: 438 GPCRNQATCLDRIGQFTC-ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCP 496
               NQ       GQ    +C     GT   +D   CQ   C  G + KD     S  CP
Sbjct: 651 ----NQVCAGGYFGQDCAQLCSCANNGTCSPID-GSCQ---CFPGWIGKD----CSQACP 698

Query: 497 SGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNV------DDCS 550
            GF G  C      C+   C NGA C    DG  C C  G+ G  C +         DC 
Sbjct: 699 PGFWGPAC---FHACS---CHNGASC-SAEDG-ACHCTPGWTGLFCTQRCPAAFFGKDCG 750

Query: 551 -PDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCP 609
               C +G   D I S  C C  G+TG  CE                          RC 
Sbjct: 751 RVCQCQNGASCDHI-SGKCTCRTGFTGQHCEQ-------------------------RCA 784

Query: 610 SGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCN 655
            GT G  C+  + +C +N     V         C C PGF G  C+
Sbjct: 785 PGTFGYGCQ-QLCECMNNSTCDHVTG------TCYCSPGFKGIRCD 823



 Score =  204 bits (518), Expect = 1e-51
 Identities = 195/715 (27%), Positives = 238/715 (33%), Gaps = 188/715 (26%)

Query: 875  CLPG------FAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL--- 925
            C PG      F  P C    +EC+   C        V+  TC C PG+GG  C       
Sbjct: 88   CCPGYYESGDFCIPLCT---EECVHGRC--------VSPDTCHCEPGWGGPDCSSGCDSD 136

Query: 926  ---PDCSPS-SCFNGG---------TCVDGVNSFSC--LCRPGYTGAHCQHEADPCLSRP 970
               P CS    C NG           C  G   + C  LC PG  G  CQ    PC    
Sbjct: 137  HWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQL---PC---Q 190

Query: 971  CLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCS-------RQPCQNGGRCVQTGAYCL 1023
            C HG  C        C C   +TG  C+ L    S       R PCQNGG C      C 
Sbjct: 191  CRHGASCDPR--AGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECA 248

Query: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV-----------C 1072
            CPPGW+G +C   + PC           +  C  GGQC       +C            C
Sbjct: 249  CPPGWTGAVC---AQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEEC 305

Query: 1073 PEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV-------DE 1125
            P G  G  C Q  D      C +GG C    G   CEC PGY G  C++ +         
Sbjct: 306  PFGSFGFQCSQHCD------CHNGGQCSPTTGA--CECEPGYKGPRCQERLCPEGLHGPG 357

Query: 1126 CASQ-PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDC-----GPGPPLDSGPRCLHN 1179
            C    PC    +         C+C PG  G  C    + C     G G  L     C + 
Sbjct: 358  CTLPCPCDADNTISCHPVTGACTCQPGWSGHHC---NESCPVGYYGDGCQLPC--TCQNG 412

Query: 1180 GTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS 1239
              C  + GG  CTC PG+ G  C                               C AG  
Sbjct: 413  ADCHSITGG--CTCAPGFMGEVCAVS----------------------------CAAGTY 442

Query: 1240 GPRCQTVLSPCESQPCQHGGQCRPSPGP------GGGLTFTCHCAQPFWGPRCERVARSC 1293
            GP C ++ S      C +GG C P  G         GL  T  C    WG  C     SC
Sbjct: 443  GPNCSSICS------CNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCN---ESC 493

Query: 1294 RELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAA-APCLHGGSCRP 1352
                C  G  C  +P    C+C PG  G +C      P G    +C+    C H   C P
Sbjct: 494  ---TCANGAAC--SPIDGSCSCTPGWLGDTCEL--PCPDGTFGLNCSEHCDCSHADGCDP 546

Query: 1353 APLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDREC---NSPG 1409
                    C C  GWTG RC+                + C   R    C   C   N   
Sbjct: 547  VT----GHCCCLAGWTGIRCD----------------STCPPGRWGPNCSVSCSCENGGS 586

Query: 1410 CGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNP 1469
            C  + G C  + G     C+ + C   F    C   C  P C++ +  CH       C P
Sbjct: 587  CSPEDGSCECAPGFRGPLCQRI-CPPGFYGHGCAQPC--PLCVHSSRPCHHISGICECLP 643

Query: 1470 VY-----EKYCADHFADGRCDQGC---NTEEC-----------GWDGLDCASEVP 1505
             +      + CA  +    C Q C   N   C           GW G DC+   P
Sbjct: 644  GFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACP 698


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  269 bits (688), Expect = 2e-71
 Identities = 128/326 (39%), Positives = 172/326 (52%), Gaps = 22/326 (6%)

Query: 376 ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVN--TQGSFLCQCGRGYTGPRCETDVN 433
           + TC PG           E       C   G+C    ++ +F C C   Y G  CE + +
Sbjct: 304 VSTCVPG-----------ESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYD 351

Query: 434 ECLSGPCRNQATCLDRI-----GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRV 488
            C   PC+N A+C+D         FTC+C+ G+TG  C+  ID C   PC NG  C   +
Sbjct: 352 ACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSL 411

Query: 489 NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDD 548
           +GF+C CP G+ GS C+  VD CAS+PC+N   C      + C C+ GF G  C + +D 
Sbjct: 412 SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDF 471

Query: 549 CSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC 608
           C+  PC HG C     S+ C C PGY G  CE + +EC S PC +   C DLV+ Y C C
Sbjct: 472 CALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531

Query: 609 PSGTTGVNCEVNIDDCASNPCTFGVC--RDGINRYDCVCQPGFTGPLCNVEINECASSPC 666
            +   G +CE+  D CA+  C  G     DG+N   C+C PGFTG  C+++INEC S+PC
Sbjct: 532 LAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPC 590

Query: 667 GEGGSCVDGENGFRCLCPPGSLPPLC 692
             GGSC+D  NG+ C CP G +   C
Sbjct: 591 HHGGSCLDQPNGYNCHCPHGWVGANC 616



 Score =  257 bits (657), Expect = 8e-68
 Identities = 128/329 (38%), Positives = 177/329 (53%), Gaps = 27/329 (8%)

Query: 224 CLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN--TYNCQCPPEWTGQFCTEDVDECQLQ 281
           C+PG      E + +D     C   G C    +  T++C C  ++ G FC E+ D CQ +
Sbjct: 307 CVPG------ESHANDL---ECSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRK 356

Query: 282 PNACHNGGTCFNTL-----GGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASF 336
           P  C N  +C +          +CVC+ G+TGE C   ID C    C +GATC   ++ F
Sbjct: 357 P--CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF 414

Query: 337 YCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDEC 395
            C CP G  G  C    D C S+PC  +  C  + V+    C C PGFTG  C Q +D C
Sbjct: 415 TCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH--FTCNCSPGFTGPTCAQLIDFC 472

Query: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
           ++  +PC H G C +   S+ C C  GY G  CE + NECLS PC N ATC D +  + C
Sbjct: 473 AL--SPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529

Query: 456 ICMAGFTGTYCEVDIDECQSSPCVNGGVC-KDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
           +C+A + GT+CE+  D C +  C+NG  C  D +NG +C C  GF+G  C +D++EC S 
Sbjct: 530 VCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSN 588

Query: 515 PCRNGAKCVDQPDGYECRCAEGFEGTLCD 543
           PC +G  C+DQP+GY C C  G+ G  C+
Sbjct: 589 PCHHGGSCLDQPNGYNCHCPHGWVGANCE 617



 Score =  249 bits (636), Expect = 2e-65
 Identities = 121/318 (38%), Positives = 161/318 (50%), Gaps = 11/318 (3%)

Query: 308 GESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAIC- 366
           GES + +++      C    T     A+F C C     G  C   DAC   PC  +A C 
Sbjct: 310 GESHANDLECSGKGKC----TTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCI 365

Query: 367 DTNPVNGRA--ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424
           D N     +   C C PG+TG  C   +D C +  +PC +   C+++   F CQC  GY 
Sbjct: 366 DANEKQDGSNFTCVCLPGYTGELCQSKIDYCIL--DPCRNGATCISSLSGFTCQCPEGYF 423

Query: 425 GPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC 484
           G  CE  V+ C S PC+N  TC      FTC C  GFTG  C   ID C  SPC +G  C
Sbjct: 424 GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TC 482

Query: 485 KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544
           +     + C C  G+ G  C+ + +EC S PC N A C D  +GYEC C   ++GT C+ 
Sbjct: 483 RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCEL 542

Query: 545 NVDDCSPDPCHHGRCVDGIA-SFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603
             D C+   C +G   D    + +C CAPG+TG  C+  ++EC S PC HGG CLD  + 
Sbjct: 543 YKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602

Query: 604 YLCRCPSGTTGVNCEVNI 621
           Y C CP G  G NCE+++
Sbjct: 603 YNCHCPHGWVGANCEIHL 620



 Score =  240 bits (613), Expect = 1e-62
 Identities = 115/323 (35%), Positives = 155/323 (47%), Gaps = 18/323 (5%)

Query: 720  CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
            C PG S     +   +  C ++P  A          F CTC     G  CE    C   P
Sbjct: 307  CVPGESHANDLECSGKGKCTTKPSEAT---------FSCTCEEQYVGTFCEEYDACQRKP 357

Query: 780  CEHGGRC----ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
            C++   C    E   G    C C  G+ G  CQ  +D C    PC     C +    F+C
Sbjct: 358  CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD-PCRNGATCISSLSGFTC 416

Query: 836  TCHGGYTGPSCDQDINDCDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCARDVDECLSN 894
             C  GY G +C++ ++ C  +PC N G+C  DGV  F+C+C PGF GP CA+ +D C  +
Sbjct: 417  QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV-HFTCNCSPGFTGPTCAQLIDFCALS 475

Query: 895  PCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY 954
            PC  GTC     S+ C C PGY G +CE++  +C  + C N  TC D VN + C+C   Y
Sbjct: 476  PCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEY 535

Query: 955  TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGR 1014
             G HC+   DPC +  CL+G  C +      C C   FTG +C   ++ C   PC +GG 
Sbjct: 536  KGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595

Query: 1015 CVQ--TGAYCLCPPGWSGRLCDI 1035
            C+    G  C CP GW G  C+I
Sbjct: 596  CLDQPNGYNCHCPHGWVGANCEI 618



 Score =  233 bits (593), Expect = 2e-60
 Identities = 121/308 (39%), Positives = 156/308 (50%), Gaps = 14/308 (4%)

Query: 87  CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARC---SVGPDG-RF 142
           C+G+G C +      A FSC C   + G  C   D C   PC + A C   +   DG  F
Sbjct: 319 CSGKGKCTTK--PSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNF 376

Query: 143 LCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCA 202
            C C PGY G  C+S +D C + +PCR+G TC+++   F CQCP GY G  CE    PCA
Sbjct: 377 TCVCLPGYTGELCQSKIDYC-ILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435

Query: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262
            SPC+N GTC   G + + C C PGF G  C   +D C    C + GTC     +Y C C
Sbjct: 436 SSPCQNNGTCYVDG-VHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLC 493

Query: 263 PPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV 322
            P + G +C E+ +EC   P  C N  TC + + G+ CVC+  + G  C    D CA   
Sbjct: 494 DPGYHGLYCEEEYNECLSAP--CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVS 551

Query: 323 CFHGATCHDRVASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPP 381
           C +GATC     +  C C  G TG  C +D + C SNPCH    C   P NG   C CP 
Sbjct: 552 CLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP-NGYN-CHCPH 609

Query: 382 GFTGGACD 389
           G+ G  C+
Sbjct: 610 GWVGANCE 617



 Score =  232 bits (591), Expect = 4e-60
 Identities = 115/312 (36%), Positives = 151/312 (48%), Gaps = 20/312 (6%)

Query: 858  CLNGGSC--QDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTD-----HVASFT 909
            C   G C  +    +FSC+C   + G  C  + D C   PC    +C D       ++FT
Sbjct: 319  CSGKGKCTTKPSEATFSCTCEEQYVGTFC-EEYDACQRKPCQNNASCIDANEKQDGSNFT 377

Query: 910  CTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSR 969
            C C PGY G  C+  +  C    C NG TC+  ++ F+C C  GY G+ C+ + DPC S 
Sbjct: 378  CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437

Query: 970  PCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGG-RCVQTGAYCLCPPGW 1028
            PC + G C      F C C   FTGP C  L+D+C+  PC +G  R V T   CLC PG+
Sbjct: 438  PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497

Query: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC 1088
             G  C+     C  A           C     C D  + + CVC     G+HCE   DPC
Sbjct: 498  HGLYCEEEYNECLSAP----------CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC 547

Query: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSC 1148
                C +G TC        C C PG+ G+ C+ D++EC S PC HGGSC+D    Y C C
Sbjct: 548  ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHC 607

Query: 1149 PPGTLGVLCEIN 1160
            P G +G  CEI+
Sbjct: 608  PHGWVGANCEIH 619



 Score =  226 bits (575), Expect = 3e-58
 Identities = 125/344 (36%), Positives = 171/344 (49%), Gaps = 46/344 (13%)

Query: 874  SCLPGFAGPRCARDVDECLSNPCGPGTCTDHV--ASFTCTCPPGYGGFHCEQDLPDCSPS 931
            +C+PG +    A D+ EC     G G CT     A+F+CTC   Y G  CE+    C   
Sbjct: 306  TCVPGESH---ANDL-EC----SGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRK 356

Query: 932  SCFNGGTCVDGV-----NSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986
             C N  +C+D       ++F+C+C PGYTG  CQ + D C+  PC +G  C ++  GF C
Sbjct: 357  PCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTC 416

Query: 987  TCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--CLCPPGWSGRLC----DIRSL-P 1039
             C E + G  C+  VD C+  PCQN G C   G +  C C PG++G  C    D  +L P
Sbjct: 417  QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP 476

Query: 1040 CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099
            C                A G C    +S+ C+C  G  G +CE+E + CL+ PC +  TC
Sbjct: 477  C----------------AHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATC 520

Query: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
            R  + GY C CL  Y G +CE   D CA+  C +G +C        C C PG  G  C+I
Sbjct: 521  RDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDI 580

Query: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
            + ++C      DS P C H G+C+D   G+ C CP G+ G  CE
Sbjct: 581  DINEC------DSNP-CHHGGSCLDQPNGYNCHCPHGWVGANCE 617



 Score =  225 bits (573), Expect = 4e-58
 Identities = 120/325 (36%), Positives = 162/325 (49%), Gaps = 18/325 (5%)

Query: 692  CLP-PSHPCAHEPCSHGICYDAPGG--FRCVCEPGWSGPRCSQSLARDACESQPCRAGGT 748
            C+P  SH    E    G C   P    F C CE  + G  C +    DAC+ +PC+   +
Sbjct: 307  CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY---DACQRKPCQNNAS 363

Query: 749  C-----SSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGW 802
            C       DG  F C C PG  G  C+  +  C  +PC +G  C S+      C CP+G+
Sbjct: 364  CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF-TCQCPEGY 422

Query: 803  QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862
             G  C++ VD CA  +PC  +G C      F+C C  G+TGP+C Q I+ C  +PC +G 
Sbjct: 423  FGSACEEKVDPCAS-SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG- 480

Query: 863  SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHC 921
            +C+    S+ C C PG+ G  C  + +ECLS PC    TC D V  + C C   Y G HC
Sbjct: 481  TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540

Query: 922  EQDLPDCSPSSCFNGGTC-VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
            E     C+  SC NG TC  DG+N  +C+C PG+TG  C  + + C S PC HGG C   
Sbjct: 541  ELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQ 599

Query: 981  HPGFRCTCLESFTGPQCQTLVDWCS 1005
              G+ C C   + G  C+  + W S
Sbjct: 600  PNGYNCHCPHGWVGANCEIHLQWKS 624



 Score =  219 bits (557), Expect = 3e-56
 Identities = 115/306 (37%), Positives = 150/306 (49%), Gaps = 9/306 (2%)

Query: 49  CANGGRCTQLPSREA-ACLCPPGWVGERCQLEDPCHSGPCAGRGVC-QSSVVAGTARFSC 106
           C+  G+CT  PS    +C C   +VG  C+  D C   PC     C  ++     + F+C
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378

Query: 107 RCPRGFRGPDC-SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165
            C  G+ G  C S  D C+  PC +GA C     G F C CP GY G +C   VD C   
Sbjct: 379 VCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPC-AS 436

Query: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225
            PC++ GTC      F C C  G+TGP C      CA SPC +G TCR  G  +Y C C 
Sbjct: 437 SPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGT-SYKCLCD 494

Query: 226 PGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNAC 285
           PG+ G  CE   ++C    CLN  TC D VN Y C C  E+ G  C    D C     +C
Sbjct: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV--SC 552

Query: 286 HNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKT 345
            NG TC +     +C+C  G+TGE C  +I++C +  C HG +C D+   + C CP G  
Sbjct: 553 LNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612

Query: 346 GLLCHL 351
           G  C +
Sbjct: 613 GANCEI 618



 Score =  202 bits (515), Expect = 2e-51
 Identities = 109/320 (34%), Positives = 151/320 (47%), Gaps = 24/320 (7%)

Query: 546 VDDCSPDPCH--------HGRCVD--GIASFSCACAPGYTGTRCESQVDECRSQPCRHGG 595
           V  C P   H         G+C      A+FSC C   Y GT CE + D C+ +PC++  
Sbjct: 304 VSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNA 362

Query: 596 KCLDLVDK-----YLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGF 649
            C+D  +K     + C C  G TG  C+  ID C  +PC  G  C   ++ + C C  G+
Sbjct: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY 422

Query: 650 TGPLCNVEINECASSPCGEGGSC-VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI 708
            G  C  +++ CASSPC   G+C VDG + F C C PG   P C      CA  PC+HG 
Sbjct: 423 FGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHGT 481

Query: 709 CYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQ 768
           C      ++C+C+PG+ G  C +    + C S PC    TC     G+ C C    +G  
Sbjct: 482 CRSVGTSYKCLCDPGYHGLYCEEEY--NECLSAPCLNAATCRDLVNGYECVCLAEYKGTH 539

Query: 769 CELL-SPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827
           CEL   PC    C +G  C+S  G    C C  G+ G  C  D++EC    PC   G C 
Sbjct: 540 CELYKDPCANVSCLNGATCDS-DGLNGTCICAPGFTGEECDIDINEC-DSNPCHHGGSCL 597

Query: 828 NLAGSFSCTCHGGYTGPSCD 847
           +    ++C C  G+ G +C+
Sbjct: 598 DQPNGYNCHCPHGWVGANCE 617



 Score =  202 bits (514), Expect = 3e-51
 Identities = 110/326 (33%), Positives = 147/326 (45%), Gaps = 38/326 (11%)

Query: 1009 CQNGGRCV----QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD- 1063
            C   G+C     +    C C   + G  C+      R+            CQ    C+D 
Sbjct: 319  CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKP-----------CQNNASCIDA 367

Query: 1064 ---EDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNC 1119
               +D S++ CVC  G TG  C+ ++D C+  PC++G TC   + G+ C+C  GY G  C
Sbjct: 368  NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSAC 427

Query: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
            E+ VD CAS PCQ+ G+C      + C+C PG  G  C    D C   P       C H 
Sbjct: 428  EEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-------CAH- 479

Query: 1180 GTCVDLVGGFRCTCPPGYTGLRCEADINECRSGAC-HAAHTRDCLQDPGGGFRCLCHAGF 1238
            GTC  +   ++C C PGY GL CE + NEC S  C +AA  RD +     G+ C+C A +
Sbjct: 480  GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLV----NGYECVCLAEY 535

Query: 1239 SGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQC 1298
             G  C+    PC +  C +G  C        GL  TC CA  F G  C+     C    C
Sbjct: 536  KGTHCELYKDPCANVSCLNGATC-----DSDGLNGTCICAPGFTGEECDIDINECDSNPC 590

Query: 1299 PVGVPCQQTPRGPRCACPPGLSGPSC 1324
              G  C   P G  C CP G  G +C
Sbjct: 591  HHGGSCLDQPNGYNCHCPHGWVGANC 616



 Score =  152 bits (383), Expect = 5e-36
 Identities = 99/319 (31%), Positives = 127/319 (39%), Gaps = 39/319 (12%)

Query: 1106 YMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR-----YLCSCPPGTLGVLCEIN 1160
            + C C   Y G  CE+  D C  +PCQ+  SCID   +     + C C PG  G LC+  
Sbjct: 334  FSCTCEEQYVGTFCEE-YDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392

Query: 1161 EDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTR 1220
             D C   P       C +  TC+  + GF C CP GY G  CE  ++ C S  C    T 
Sbjct: 393  IDYCILDP-------CRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGT- 444

Query: 1221 DCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQP 1280
             C  D G  F C C  GF+GP C  ++  C   PC HG  CR       G ++ C C   
Sbjct: 445  -CYVD-GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSV-----GTSYKCLCDPG 496

Query: 1281 FWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCA 1340
            + G  CE     C    C     C+    G  C C     G  C  +           CA
Sbjct: 497  YHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELY--------KDPCA 548

Query: 1341 AAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQR 1400
               CL+G +C    L     C CA G+TG  C+      E    P     +C     DQ 
Sbjct: 549  NVSCLNGATCDSDGLNG--TCICAPGFTGEECDID--INECDSNPCHHGGSCL----DQP 600

Query: 1401 CDRECNSPGCGWDGGDCSL 1419
                C+ P  GW G +C +
Sbjct: 601  NGYNCHCPH-GWVGANCEI 618



 Score =  135 bits (339), Expect = 6e-31
 Identities = 82/236 (34%), Positives = 98/236 (41%), Gaps = 49/236 (20%)

Query: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFSC 106
           PC NG  C    S    C CP G+ G  C+ + DPC S PC   G C    V     F+C
Sbjct: 400 PCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV----HFTC 454

Query: 107 RCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165
            C  GF GP C+ L D C  SPCAHG   SVG    + C C PGY G  C  + +EC + 
Sbjct: 455 NCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTS--YKCLCDPGYHGLYCEEEYNEC-LS 511

Query: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225
            PC +  TC +    + C C A Y G  CE    PCA   C NG TC   G L   C C 
Sbjct: 512 APCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDG-LNGTCICA 570

Query: 226 PGFEGQ--------------------------------------NCEVNVDDCPGH 243
           PGF G+                                      NCE+++    GH
Sbjct: 571 PGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGH 626



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 38/87 (43%), Positives = 47/87 (54%), Gaps = 15/87 (17%)

Query: 473 CQSSPCVNGGVCKDRVN------------GFSCTCPSGFSGSTCQLDVDECASTPCRNG- 519
           C + PC NGGVC  R              G+SCTCP+G SG+ CQL  D CAS PC +G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 520 --AKCVDQPDGYECRCAEGFEGTLCDR 544
             +      DGY C C EG+EG  C++
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 58/161 (36%), Positives = 66/161 (40%), Gaps = 49/161 (30%)

Query: 12  RRPMSPPPPPPPVRALPLLLLLAGPGA--------AAP-----PCLDGSPCANGGRCTQL 58
           RR  +P     P  AL LLLL AGP          AAP     PC    PC NGG CT  
Sbjct: 4   RRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCA-AQPCRNGGVCTSR 62

Query: 59  PSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS 118
           P                    DP H  P            AG   +SC CP G  G +C 
Sbjct: 63  PE------------------PDPQHPAP------------AGEPGYSCTCPAGISGANCQ 92

Query: 119 L-PDPCLSSPCAHG---ARCSVGPDGRFLCSCPPGYQGRSC 155
           L  DPC S+PC HG   +  S   DG +LC C  GY+G +C
Sbjct: 93  LVADPCASNPCHHGNCSSSSSSSSDG-YLCICNEGYEGPNC 132



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 34/88 (38%), Positives = 47/88 (53%), Gaps = 17/88 (19%)

Query: 738 CESQPCRAGGTCSS------------DGMGFHCTCPPGVQGRQCELLS-PCTPNPCEHGG 784
           C +QPCR GG C+S               G+ CTCP G+ G  C+L++ PC  NPC H G
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-G 106

Query: 785 RCESAPGQLP---VCSCPQGWQGPRCQQ 809
            C S+        +C C +G++GP C+Q
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 33/86 (38%), Positives = 39/86 (45%), Gaps = 16/86 (18%)

Query: 511 CASTPCRNGAKCVDQPD------------GYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558
           CA+ PCRNG  C  +P+            GY C C  G  G  C    D C+ +PCHHG 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 559 CVDGIASFS----CACAPGYTGTRCE 580
           C    +S S    C C  GY G  CE
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/85 (37%), Positives = 42/85 (49%), Gaps = 16/85 (18%)

Query: 586 CRSQPCRHGGKCLDLVDK------------YLCRCPSGTTGVNCEVNIDDCASNPCTFGV 633
           C +QPCR+GG C    +             Y C CP+G +G NC++  D CASNPC  G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 634 CRDGINR----YDCVCQPGFTGPLC 654
           C    +     Y C+C  G+ GP C
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 16/89 (17%)

Query: 661 CASSPCGEGGSCVD------------GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI 708
           CA+ PC  GG C              GE G+ C CP G     C   + PCA  PC HG 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 709 CYDAPG----GFRCVCEPGWSGPRCSQSL 733
           C  +      G+ C+C  G+ GP C Q+L
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 32/86 (37%), Positives = 41/86 (47%), Gaps = 15/86 (17%)

Query: 928 CSPSSCFNGGTCVD------------GVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGG 975
           C+   C NGG C              G   +SC C  G +GA+CQ  ADPC S PC HG 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 976 V---CSAAHPGFRCTCLESFTGPQCQ 998
                S++  G+ C C E + GP C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 166 EPCRHGGTCLNTPG------------SFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCR 213
           +PCR+GG C + P              + C CPAG +G  C+  A PCA +PC +G    
Sbjct: 51  QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSS 110

Query: 214 QSGDLT--YDCACLPGFEGQNCEVNVDDCP 241
            S   +  Y C C  G+EG NCE  +   P
Sbjct: 111 SSSSSSDGYLCICNEGYEGPNCEQALPSLP 140



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 16/90 (17%)

Query: 853 CDPNPCLNGGSCQD------------GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT 900
           C   PC NGG C              G   +SC+C  G +G  C    D C SNPC  G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 901 CTDHVAS----FTCTCPPGYGGFHCEQDLP 926
           C+   +S    + C C  GY G +CEQ LP
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP 137



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 35/90 (38%), Positives = 43/90 (47%), Gaps = 17/90 (18%)

Query: 774 PCTPNPCEHGGRCESAPGQLPV-----------CSCPQGWQGPRCQQDVDECAGPAPCGP 822
           PC   PC +GG C S P   P            C+CP G  G  CQ   D CA   PC  
Sbjct: 47  PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN-PCH- 104

Query: 823 HGICTNLAGSFS----CTCHGGYTGPSCDQ 848
           HG C++ + S S    C C+ GY GP+C+Q
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 37/120 (30%)

Query: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
            C+ QPC+NGG                  +C  R  P  +  A  G               
Sbjct: 48   CAAQPCRNGG------------------VCTSRPEPDPQHPAPAG--------------- 74

Query: 1064 EDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHG---GTCRGYMGGYMCECLPGYNGDNCE 1120
             +  + C CP G +G++C+   DPC + PC HG    +      GY+C C  GY G NCE
Sbjct: 75   -EPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 33/101 (32%), Positives = 46/101 (45%), Gaps = 16/101 (15%)

Query: 118 SLPDPCLSSPCAHGARCSVGP-----------DGRFLCSCPPGYQGRSCRSDVDECRVGE 166
           S P PC + PC +G  C+  P           +  + C+CP G  G +C+   D C    
Sbjct: 43  SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC-ASN 101

Query: 167 PCRHGGTCLNTPGS---FRCQCPAGYTGPLCENPAVPCAPS 204
           PC HG    ++  S   + C C  GY GP CE  A+P  P+
Sbjct: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ-ALPSLPA 141



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 34/87 (39%), Positives = 38/87 (43%), Gaps = 15/87 (17%)

Query: 1087 PCLAQPCQHGGTCRGYMG------------GYMCECLPGYNGDNCEDDVDECASQPCQHG 1134
            PC AQPC++GG C                 GY C C  G +G NC+   D CAS PC HG
Sbjct: 47   PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106

Query: 1135 ---GSCIDLVARYLCSCPPGTLGVLCE 1158
                S       YLC C  G  G  CE
Sbjct: 107  NCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 19/94 (20%)

Query: 965  PCLSRPCLHGGVCS------------AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNG 1012
            PC ++PC +GGVC+            A  PG+ CTC    +G  CQ + D C+  PC +G
Sbjct: 47   PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106

Query: 1013 -----GRCVQTGAYCLCPPGWSGRLCD--IRSLP 1039
                       G  C+C  G+ G  C+  + SLP
Sbjct: 107  NCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 33/122 (27%)

Query: 1126 CASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDL 1185
            CA+QPC++GG C                      +  +  P  P  +G            
Sbjct: 48   CAAQPCRNGGVCT---------------------SRPEPDPQHPAPAGEP---------- 76

Query: 1186 VGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQT 1245
              G+ CTCP G +G  C+   + C S  CH  +          G+ C+C+ G+ GP C+ 
Sbjct: 77   --GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134

Query: 1246 VL 1247
             L
Sbjct: 135  AL 136



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 31/88 (35%), Positives = 38/88 (43%), Gaps = 6/88 (6%)

Query: 1209 CRSGACHAAHTRDCLQDPGG----GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPS 1264
            CR+G    +      Q P      G+ C C AG SG  CQ V  PC S PC HG     S
Sbjct: 53   CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSS 112

Query: 1265 PGPGGGLTFTCHCAQPFWGPRCERVARS 1292
                 G  + C C + + GP CE+   S
Sbjct: 113  SSSSDG--YLCICNEGYEGPNCEQALPS 138



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 38/112 (33%), Positives = 44/112 (39%), Gaps = 20/112 (17%)

Query: 682 LCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPG------------GFRCVCEPGWSGPR 728
           L  P    PL  P   PCA +PC +G +C   P             G+ C C  G SG  
Sbjct: 33  LANPVPAAPLSAPG--PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN 90

Query: 729 CSQSLARDACESQPCRAGGTCSSDGM---GFHCTCPPGVQGRQCELLSPCTP 777
           C   L  D C S PC  G   SS      G+ C C  G +G  CE   P  P
Sbjct: 91  CQ--LVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 37/128 (28%), Positives = 50/128 (39%), Gaps = 44/128 (34%)

Query: 1249 PCESQPCQHGGQC--RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQ 1306
            PC +QPC++GG C  RP P P                           +   P G P   
Sbjct: 47   PCAAQPCRNGGVCTSRPEPDP---------------------------QHPAPAGEP--- 76

Query: 1307 TPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG-SCRPAPLAPFFRCACAQ 1365
               G  C CP G+SG +C+             CA+ PC HG  S   +  +  + C C +
Sbjct: 77   ---GYSCTCPAGISGANCQLVADP--------CASNPCHHGNCSSSSSSSSDGYLCICNE 125

Query: 1366 GWTGPRCE 1373
            G+ GP CE
Sbjct: 126  GYEGPNCE 133



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 34/109 (31%), Positives = 42/109 (38%), Gaps = 26/109 (23%)

Query: 200 PCAPSPCRNGGTCRQ-----------SGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNG 248
           PCA  PCRNGG C             +G+  Y C C  G  G NC++  D C  + C +G
Sbjct: 47  PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106

Query: 249 G--------------TCVDGVNTYNC-QCPPEWTGQFCTEDVDECQLQP 282
                           C +G    NC Q  P       TE +   QLQP
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQP 155



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 15/86 (17%)

Query: 435 CLSGPCRNQATCLDR----------IGQ--FTCICMAGFTGTYCEVDIDECQSSPCVNGG 482
           C + PCRN   C  R           G+  ++C C AG +G  C++  D C S+PC +G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 483 V---CKDRVNGFSCTCPSGFSGSTCQ 505
                    +G+ C C  G+ G  C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 25/86 (29%), Positives = 38/86 (44%), Gaps = 16/86 (18%)

Query: 891 CLSNPC-GPGTCTD-------HVA-----SFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG 937
           C + PC   G CT        H A      ++CTCP G  G +C+     C+ + C +G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 938 TCVDGVNS---FSCLCRPGYTGAHCQ 960
                 +S   + C+C  GY G +C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)

Query: 318 CATAVCFHGATCHDRVA------------SFYCACPMGKTGLLCHL-DDACVSNPCHE-D 363
           CA   C +G  C  R               + C CP G +G  C L  D C SNPCH  +
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 364 AICDTNPVNGRAICTCPPGFTGGACDQ 390
               ++  +   +C C  G+ G  C+Q
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 19/88 (21%)

Query: 278 CQLQPNACHNGGTCFNTLG------------GHSCVCVNGWTGESCSQNIDDCATAVCFH 325
           C  QP  C NGG C +               G+SC C  G +G +C    D CA+  C H
Sbjct: 48  CAAQP--CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105

Query: 326 GATCHDRVAS----FYCACPMGKTGLLC 349
           G  C    +S    + C C  G  G  C
Sbjct: 106 G-NCSSSSSSSSDGYLCICNEGYEGPNC 132



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 24/101 (23%), Positives = 36/101 (35%), Gaps = 11/101 (10%)

Query: 370 PVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
           P++    C   P   GG C    +       P    G        + C C  G +G  C+
Sbjct: 41  PLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPG--------YSCTCPAGISGANCQ 92

Query: 430 TDVNECLSGPCRN---QATCLDRIGQFTCICMAGFTGTYCE 467
              + C S PC +    ++       + CIC  G+ G  CE
Sbjct: 93  LVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 7/62 (11%)

Query: 33  LAGPGAAAPPC------LDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP 86
           +  PG     C       D +PC +GG C   P+    C CP GWVG  C++     SG 
Sbjct: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYN-CHCPHGWVGANCEIHLQWKSGH 626

Query: 87  CA 88
            A
Sbjct: 627 MA 628



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 47/178 (26%), Positives = 61/178 (34%), Gaps = 42/178 (23%)

Query: 1332 PGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAA 1391
            PG S+A+     C   G C   P    F C C + + G  CE         E   C R  
Sbjct: 309  PGESHAN--DLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE---------EYDACQRKP 357

Query: 1392 CQ--AKRGDQRCDRECNSPGC----GWDGGDCSLSVG----DPWRQCE---------ALQ 1432
            CQ  A   D    ++ ++  C    G+ G  C   +     DP R              Q
Sbjct: 358  CQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQ 417

Query: 1433 CWRLFNNSRC----DPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQ 1486
            C   +  S C    DP  SSP    +N  C+  G   TCN      C+  F    C Q
Sbjct: 418  CPEGYFGSACEEKVDPCASSPC--QNNGTCYVDGVHFTCN------CSPGFTGPTCAQ 467



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 32/113 (28%), Positives = 45/113 (39%), Gaps = 21/113 (18%)

Query: 1320 SGPSCRSFPGSPPGASNAS---CAAAPCLHGGSC---------RPAPLA-PFFRCACAQG 1366
            +GP   S     P A  ++   CAA PC +GG C          PAP   P + C C  G
Sbjct: 26   AGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAG 85

Query: 1367 WTGPRCE--APAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
             +G  C+  A   A        C  ++  +  G   C   CN    G++G +C
Sbjct: 86   ISGANCQLVADPCASNPCHHGNCSSSSSSSSDG-YLC--ICNE---GYEGPNC 132


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  268 bits (685), Expect = 5e-71
 Identities = 140/356 (39%), Positives = 179/356 (50%), Gaps = 29/356 (8%)

Query: 711  DAPGGFRC------VCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGV 764
            DA G F C      VC PGW GP C++ +    C+ Q     G C   G    C C  G 
Sbjct: 197  DAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQH----GFCDKPG---ECKCRVGW 249

Query: 765  QGRQCELLSPCTPNP-CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPH 823
            QGR C+    C   P C HG  C+  P Q   C+C +GW G  C QD++ C    PC   
Sbjct: 250  QGRYCD---ECIRYPGCLHG-TCQQ-PWQ---CNCQEGWGGLFCNQDLNYCTHHKPCKNG 301

Query: 824  GICTNLA-GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGP 882
              CTN   GS++C+C  GYTG +C+  I++CDP+PC NGGSC D   S+SC+C PGF G 
Sbjct: 302  ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361

Query: 883  RCARDVDECLSNPC-GPGTCTDHV-ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCV 940
             C      C   PC   G C+D     ++C CP GY GF+CE+ +  CS S C NG  CV
Sbjct: 362  ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421

Query: 941  DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL 1000
            D  +++ C C+ G++G HC    D C S PC +GG C      F CTC   +TG  C   
Sbjct: 422  DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481

Query: 1001 VDWCSRQPCQNGGRCVQTG--AYCLCPPGWSGRLCD--IRSLPCREAAAQIGVRLE 1052
            V  C   PC NG  C + G    C C  G+ G  C   +  LP   A   +  +LE
Sbjct: 482  VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLE 537



 Score =  265 bits (676), Expect = 5e-70
 Identities = 132/331 (39%), Positives = 170/331 (51%), Gaps = 17/331 (5%)

Query: 301 VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360
           VC  GW G  C++ I  C          C D+     C C +G  G  C   D C+  P 
Sbjct: 211 VCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYC---DECIRYPG 262

Query: 361 HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT-QGSFLCQC 419
                C   P      C C  G+ G  C+QD++ C+    PC++   C NT QGS+ C C
Sbjct: 263 CLHGTCQ-QPWQ----CNCQEGWGGLFCNQDLNYCT-HHKPCKNGATCTNTGQGSYTCSC 316

Query: 420 GRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCV 479
             GYTG  CE  ++EC   PC+N  +C D    ++C C  GF G  CE+    C   PC 
Sbjct: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376

Query: 480 NGGVCKDRVNG-FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE 538
           NGG C D  +G +SC CP G+SG  C+  +D C+S+PC NGAKCVD  D Y CRC  GF 
Sbjct: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS 436

Query: 539 GTLCDRNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKC 597
           G  CD NVDDC+  PC +G  C DG+  FSC C PGYTG  C + V  C   PC +G  C
Sbjct: 437 GRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATC 496

Query: 598 LDLVDKYLCRCPSGTTGVNCEVNIDDCASNP 628
            +   +Y+C C  G  G NC+  + +    P
Sbjct: 497 HERGHRYVCECARGYGGPNCQFLLPELPPGP 527



 Score =  259 bits (661), Expect = 3e-68
 Identities = 145/373 (38%), Positives = 183/373 (49%), Gaps = 31/373 (8%)

Query: 301 VCVNGWTGESCS---QNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS 357
           VC   + GE CS   +  DD      F   TC +R       C  G  G  C  +  C+ 
Sbjct: 178 VCDEHYYGEGCSVFCRPRDDA-----FGHFTCGERGEK---VCNPGWKGPYC-TEPICLP 228

Query: 358 NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLC 417
               +   CD         C C  G+ G  CD    EC I    C H G C   Q  + C
Sbjct: 229 GCDEQHGFCDKP-----GECKCRVGWQGRYCD----EC-IRYPGCLH-GTC---QQPWQC 274

Query: 418 QCGRGYTGPRCETDVNECLSG-PCRNQATCLDR-IGQFTCICMAGFTGTYCEVDIDECQS 475
            C  G+ G  C  D+N C    PC+N ATC +   G +TC C  G+TG  CE+ IDEC  
Sbjct: 275 NCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDP 334

Query: 476 SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG-YECRCA 534
           SPC NGG C D  N +SCTCP GF G  C+L    CA  PC NG +C D PDG Y CRC 
Sbjct: 335 SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCP 394

Query: 535 EGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRH 593
            G+ G  C++ +D CS  PC +G +CVD   ++ C C  G++G  C+  VD+C S PC +
Sbjct: 395 VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN 454

Query: 594 GGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGP 652
           GG C D V+ + C CP G TG NC   +  C   PC  G  C +  +RY C C  G+ GP
Sbjct: 455 GGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514

Query: 653 LCNVEINECASSP 665
            C   + E    P
Sbjct: 515 NCQFLLPELPPGP 527



 Score =  254 bits (650), Expect = 5e-67
 Identities = 125/328 (38%), Positives = 179/328 (54%), Gaps = 25/328 (7%)

Query: 379 CPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG 438
           C PG+ G  C + +  C  G +  E  G C +  G   C+C  G+ G  C+    EC+  
Sbjct: 212 CNPGWKGPYCTEPI--CLPGCD--EQHGFC-DKPGE--CKCRVGWQGRYCD----ECIRY 260

Query: 439 PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC-QSSPCVNGGVCKDRVNG-FSCTCP 496
           P     TC      + C C  G+ G +C  D++ C    PC NG  C +   G ++C+C 
Sbjct: 261 PGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317

Query: 497 SGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH 556
            G++G+TC+L +DEC  +PC+NG  C D  + Y C C  GF G +C+ +   C+  PC +
Sbjct: 318 PGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFN 377

Query: 557 G-RCVDGI-ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG 614
           G RC D     +SC C  GY+G  CE ++D C S PC +G KC+DL D YLCRC +G +G
Sbjct: 378 GGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437

Query: 615 VNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCV 673
            +C+ N+DDCAS+PC   G CRDG+N + C C PG+TG  C+  ++ C  +PC  G +C 
Sbjct: 438 RHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCH 497

Query: 674 DGENGFRCLCPPGSLPPLC------LPP 695
           +  + + C C  G   P C      LPP
Sbjct: 498 ERGHRYVCECARGYGGPNCQFLLPELPP 525



 Score =  251 bits (641), Expect = 6e-66
 Identities = 136/356 (38%), Positives = 178/356 (50%), Gaps = 32/356 (8%)

Query: 388 CDQDV--DECSIGANPCEHLGRCVNTQGSFLCQ------CGRGYTGPRCETDVNECLSGP 439
           CD+    + CS+   P +      +  G F C       C  G+ GP C   +  CL G 
Sbjct: 179 CDEHYYGEGCSVFCRPRD------DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPG- 229

Query: 440 CRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF 499
           C  Q    D+ G+  C C  G+ G YC    DEC   P    G C+     + C C  G+
Sbjct: 230 CDEQHGFCDKPGE--CKCRVGWQGRYC----DECIRYPGCLHGTCQQP---WQCNCQEGW 280

Query: 500 SGSTCQLDVDECAS-TPCRNGAKCVDQPDG-YECRCAEGFEGTLCDRNVDDCSPDPCHHG 557
            G  C  D++ C    PC+NGA C +   G Y C C  G+ G  C+  +D+C P PC +G
Sbjct: 281 GGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNG 340

Query: 558 -RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK-YLCRCPSGTTGV 615
             C D   S+SC C PG+ G  CE     C   PC +GG+C D  D  Y CRCP G +G 
Sbjct: 341 GSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGF 400

Query: 616 NCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVD 674
           NCE  ID C+S+PC+ G  C D  + Y C CQ GF+G  C+  +++CASSPC  GG+C D
Sbjct: 401 NCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRD 460

Query: 675 GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRC 729
           G N F C CPPG     C  P   C H PC +G  C++    + C C  G+ GP C
Sbjct: 461 GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNC 516



 Score =  244 bits (624), Expect = 5e-64
 Identities = 139/381 (36%), Positives = 185/381 (48%), Gaps = 34/381 (8%)

Query: 180 SFRCQCPAGYTGPLCENPAVPCAPSPCRNGG-TCRQSGDLTYDCACLPGFEGQNCEVNVD 238
           S+R  C   Y G  C   +V C P     G  TC + G+      C PG++G  C   + 
Sbjct: 174 SYRFVCDEHYYGEGC---SVFCRPRDDAFGHFTCGERGEKV----CNPGWKGPYCTEPI- 225

Query: 239 DCPGHRCLNGGTCVDGV--NTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLG 296
                 CL G     G       C+C   W G++C    DEC   P   H  GTC     
Sbjct: 226 ------CLPGCDEQHGFCDKPGECKCRVGWQGRYC----DECIRYPGCLH--GTCQQPW- 272

Query: 297 GHSCVCVNGWTGESCSQNIDDCAT-AVCFHGATCHDR-VASFYCACPMGKTGLLCHLD-D 353
              C C  GW G  C+Q+++ C     C +GATC +    S+ C+C  G TG  C L  D
Sbjct: 273 --QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330

Query: 354 ACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT-Q 412
            C  +PC     C    +     CTCPPGF G  C+     C+ G  PC + GRC ++  
Sbjct: 331 ECDPSPCKNGGSC--TDLENSYSCTCPPGFYGKICELSAMTCADG--PCFNGGRCSDSPD 386

Query: 413 GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDE 472
           G + C+C  GY+G  CE  ++ C S PC N A C+D    + C C AGF+G +C+ ++D+
Sbjct: 387 GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDD 446

Query: 473 CQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECR 532
           C SSPC NGG C+D VN FSCTCP G++G  C   V  C   PC NGA C ++   Y C 
Sbjct: 447 CASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCE 506

Query: 533 CAEGFEGTLCDRNVDDCSPDP 553
           CA G+ G  C   + +  P P
Sbjct: 507 CARGYGGPNCQFLLPELPPGP 527



 Score =  238 bits (608), Expect = 4e-62
 Identities = 135/380 (35%), Positives = 176/380 (46%), Gaps = 40/380 (10%)

Query: 798  CPQGWQGPRCQ---QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
            C + + G  C    +  D+  G   CG  G            C+ G+ GP C + I  C 
Sbjct: 179  CDEHYYGEGCSVFCRPRDDAFGHFTCGERG---------EKVCNPGWKGPYCTEPI--CL 227

Query: 855  PNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP-CGPGTCTDHVASFTCTCP 913
            P      G C D  G   C C  G+ G  C    DEC+  P C  GTC      + C C 
Sbjct: 228  PGCDEQHGFC-DKPGE--CKCRVGWQGRYC----DECIRYPGCLHGTCQQ---PWQCNCQ 277

Query: 914  PGYGGFHCEQDLPDCSPSS-CFNGGTCVD-GVNSFSCLCRPGYTGAHCQHEADPCLSRPC 971
             G+GG  C QDL  C+    C NG TC + G  S++C CRPGYTGA C+   D C   PC
Sbjct: 278  EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC 337

Query: 972  LHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT---GAYCLCPPGW 1028
             +GG C+     + CTC   F G  C+     C+  PC NGGRC  +   G  C CP G+
Sbjct: 338  KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY 397

Query: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC 1088
            SG  C+ +   C  +           C  G +CVD   ++ C C  G +G HC+  VD C
Sbjct: 398  SGFNCEKKIDYCSSSP----------CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC 447

Query: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSC 1148
             + PC +GGTCR  +  + C C PGY G NC   V  C   PC +G +C +   RY+C C
Sbjct: 448  ASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCEC 507

Query: 1149 PPGTLGVLCEINEDDCGPGP 1168
              G  G  C+    +  PGP
Sbjct: 508  ARGYGGPNCQFLLPELPPGP 527



 Score =  235 bits (600), Expect = 3e-61
 Identities = 119/317 (37%), Positives = 156/317 (49%), Gaps = 20/317 (6%)

Query: 35  GPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQ 94
           GP    P CL G    +G        +   C C  GW G  C   D C   P    G CQ
Sbjct: 218 GPYCTEPICLPGCDEQHG-----FCDKPGECKCRVGWQGRYC---DECIRYPGCLHGTCQ 269

Query: 95  SSVVAGTARFSCRCPRGFRGPDCSLP-DPCLS-SPCAHGARCSVGPDGRFLCSCPPGYQG 152
                    + C C  G+ G  C+   + C    PC +GA C+    G + CSC PGY G
Sbjct: 270 QP-------WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322

Query: 153 RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC 212
            +C   +DEC    PC++GG+C +   S+ C CP G+ G +CE  A+ CA  PC NGG C
Sbjct: 323 ATCELGIDECDPS-PCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRC 381

Query: 213 RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
             S D  Y C C  G+ G NCE  +D C    C NG  CVD  + Y C+C   ++G+ C 
Sbjct: 382 SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441

Query: 273 EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR 332
           ++VD+C   P  C NGGTC + +   SC C  G+TG +CS  +  C  A C +GATCH+R
Sbjct: 442 DNVDDCASSP--CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499

Query: 333 VASFYCACPMGKTGLLC 349
              + C C  G  G  C
Sbjct: 500 GHRYVCECARGYGGPNC 516



 Score =  233 bits (593), Expect = 2e-60
 Identities = 139/396 (35%), Positives = 180/396 (45%), Gaps = 45/396 (11%)

Query: 219 TYDCACLPGFEGQNCEVNV---DDCPGH-RCLNGGTCVDGVNTYNCQCPPEWTGQFCTED 274
           +Y   C   + G+ C V     DD  GH  C   G  V         C P W G +CTE 
Sbjct: 174 SYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKV---------CNPGWKGPYCTEP 224

Query: 275 V--DECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV-CFHGATCHD 331
           +    C  Q   C   G          C C  GW G  C    D+C     C HG TC  
Sbjct: 225 ICLPGCDEQHGFCDKPG---------ECKCRVGWQGRYC----DECIRYPGCLHG-TCQQ 270

Query: 332 RVASFYCACPMGKTGLLCHLD-DACVSN-PCHEDAICDTNPVNGRAICTCPPGFTGGACD 389
               + C C  G  GL C+ D + C  + PC   A C TN   G   C+C PG+TG  C+
Sbjct: 271 ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC-TNTGQGSYTCSCRPGYTGATCE 326

Query: 390 QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDR 449
             +DEC    +PC++ G C + + S+ C C  G+ G  CE     C  GPC N   C D 
Sbjct: 327 LGIDECD--PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDS 384

Query: 450 I-GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV 508
             G ++C C  G++G  CE  ID C SSPC NG  C D  + + C C +GFSG  C  +V
Sbjct: 385 PDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV 444

Query: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFS 567
           D+CAS+PC NG  C D  + + C C  G+ G  C   V  C   PCH+G  C +    + 
Sbjct: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYV 504

Query: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603
           C CA GY G  C+  + E    P       +DL +K
Sbjct: 505 CECARGYGGPNCQFLLPELPPGPA-----VVDLTEK 535



 Score =  224 bits (570), Expect = 1e-57
 Identities = 129/348 (37%), Positives = 171/348 (49%), Gaps = 38/348 (10%)

Query: 448 DRIGQFTC------ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGF-----SCTCP 496
           D  G FTC      +C  G+ G YC   I       C+ G  C D  +GF      C C 
Sbjct: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI-------CLPG--C-DEQHGFCDKPGECKCR 246

Query: 497 SGFSGSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPD-PC 554
            G+ G  C    DEC   P C +G     QP  ++C C EG+ G  C+++++ C+   PC
Sbjct: 247 VGWQGRYC----DECIRYPGCLHGT--CQQP--WQCNCQEGWGGLFCNQDLNYCTHHKPC 298

Query: 555 HHGR-CVD-GIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGT 612
            +G  C + G  S++C+C PGYTG  CE  +DEC   PC++GG C DL + Y C CP G 
Sbjct: 299 KNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGF 358

Query: 613 TGVNCEVNIDDCASNPC-TFGVCRDGINR-YDCVCQPGFTGPLCNVEINECASSPCGEGG 670
            G  CE++   CA  PC   G C D  +  Y C C  G++G  C  +I+ C+SSPC  G 
Sbjct: 359 YGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGA 418

Query: 671 SCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRC 729
            CVD  + + C C  G     C      CA  PC++G  C D    F C C PG++G  C
Sbjct: 419 KCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478

Query: 730 SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTP 777
           S  ++R  CE  PC  G TC   G  + C C  G  G  C+ L P  P
Sbjct: 479 SAPVSR--CEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP 524



 Score =  217 bits (553), Expect = 9e-56
 Identities = 126/352 (35%), Positives = 158/352 (44%), Gaps = 43/352 (12%)

Query: 988  CLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD--IRSLPCREAAA 1045
            C   + GP C   +  C     +  G C + G  C C  GW GR CD  IR   C     
Sbjct: 212  CNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE-CKCRVGWQGRYCDECIRYPGC----- 263

Query: 1046 QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA-QPCQHGGTCRGY-M 1103
                 L   CQ   QC          C EG  G  C Q+++ C   +PC++G TC     
Sbjct: 264  -----LHGTCQQPWQCN---------CQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ 309

Query: 1104 GGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDD 1163
            G Y C C PGY G  CE  +DEC   PC++GGSC DL   Y C+CPPG  G +CE++   
Sbjct: 310  GSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369

Query: 1164 CGPGPPLDSGPRCLHNGTCVDLV-GGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDC 1222
            C  GP       C + G C D   GG+ C CP GY+G  CE  I+ C S  C  ++   C
Sbjct: 370  CADGP-------CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC--SNGAKC 420

Query: 1223 LQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW 1282
            + D G  + C C AGFSG  C   +  C S PC +GG CR      G   F+C C   + 
Sbjct: 421  V-DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCR-----DGVNDFSCTCPPGYT 474

Query: 1283 GPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR-SFPGSPPG 1333
            G  C      C    C  G  C +      C C  G  GP+C+   P  PPG
Sbjct: 475  GRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526



 Score =  194 bits (494), Expect = 6e-49
 Identities = 120/397 (30%), Positives = 163/397 (41%), Gaps = 61/397 (15%)

Query: 984  FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREA 1043
            +R  C E + G  C        R        C + G   +C PGW G  C          
Sbjct: 175  YRFVCDEHYYGEGCSVFCR--PRDDAFGHFTCGERGEK-VCNPGWKGPYCT--------- 222

Query: 1044 AAQIGVRLEQLCQAGGQCVDE----DSSHYCVCPEGRTGSHCEQEVDPCLAQP-CQHGGT 1098
                    E +C  G  C ++    D    C C  G  G +C    D C+  P C HG T
Sbjct: 223  --------EPICLPG--CDEQHGFCDKPGECKCRVGWQGRYC----DECIRYPGCLHG-T 267

Query: 1099 CRGYMGGYMCECLPGYNGDNCEDDVDECAS-QPCQHGGSCIDL-VARYLCSCPPGTLGVL 1156
            C+     + C C  G+ G  C  D++ C   +PC++G +C +     Y CSC PG  G  
Sbjct: 268  CQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGAT 324

Query: 1157 CEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHA 1216
            CE+  D+C P P       C + G+C DL   + CTCPPG+ G  CE     C  G C  
Sbjct: 325  CELGIDECDPSP-------CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFN 377

Query: 1217 AHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCH 1276
                 C   P GG+ C C  G+SG  C+  +  C S PC +G +C        G  + C 
Sbjct: 378  GGR--CSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL-----GDAYLCR 430

Query: 1277 CAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASN 1336
            C   F G  C+     C    C  G  C+       C CPPG +G +C         A  
Sbjct: 431  CQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC--------SAPV 482

Query: 1337 ASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
            + C  APC +G +C        + C CA+G+ GP C+
Sbjct: 483  SRCEHAPCHNGATCHER--GHRYVCECARGYGGPNCQ 517



 Score =  152 bits (384), Expect = 4e-36
 Identities = 103/344 (29%), Positives = 140/344 (40%), Gaps = 42/344 (12%)

Query: 1071 VCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQP 1130
            VC  G  G +C + +  CL    +  G C        C+C  G+ G  C    DEC   P
Sbjct: 211  VCNPGWKGPYCTEPI--CLPGCDEQHGFCDK---PGECKCRVGWQGRYC----DECIRYP 261

Query: 1131 -CQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGF 1189
             C HG +C      + C+C  G  G+ C  + + C    P  +G  C + G      G +
Sbjct: 262  GCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ-----GSY 312

Query: 1190 RCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP 1249
             C+C PGYTG  CE  I+EC    C    +   L++    + C C  GF G  C+     
Sbjct: 313  TCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN---SYSCTCPPGFYGKICELSAMT 369

Query: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
            C   PC +GG+C  SP  G    ++C C   + G  CE+    C    C  G  C     
Sbjct: 370  CADGPCFNGGRCSDSPDGG----YSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425

Query: 1310 GPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTG 1369
               C C  G SG  C          +   CA++PC +GG+CR       F C C  G+TG
Sbjct: 426  AYLCRCQAGFSGRHCDD--------NVDDCASSPCANGGTCRDG--VNDFSCTCPPGYTG 475

Query: 1370 PRCEAPAAAPEVSEEPRCPRAACQAKRGDQ---RCDRECNSPGC 1410
              C AP +     E   C   A   +RG +    C R    P C
Sbjct: 476  RNCSAPVSR---CEHAPCHNGATCHERGHRYVCECARGYGGPNC 516



 Score =  129 bits (325), Expect = 3e-29
 Identities = 71/170 (41%), Positives = 90/170 (52%), Gaps = 11/170 (6%)

Query: 39  AAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSV 97
           +A  C DG PC NGGRC+  P    +C CP G+ G  C+ + D C S PC+    C   V
Sbjct: 366 SAMTCADG-PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC---V 421

Query: 98  VAGTARFSCRCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
             G A + CRC  GF G  C    D C SSPCA+G  C  G +  F C+CPPGY GR+C 
Sbjct: 422 DLGDA-YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND-FSCTCPPGYTGRNCS 479

Query: 157 SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE--NPAVPCAPS 204
           + V  C    PC +G TC      + C+C  GY GP C+   P +P  P+
Sbjct: 480 APVSRCEHA-PCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528



 Score =  120 bits (301), Expect = 2e-26
 Identities = 116/443 (26%), Positives = 162/443 (36%), Gaps = 86/443 (19%)

Query: 1047 IGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGY 1106
            +G    Q   + G+  D   S+  VC E   G  C      C  +    G    G  G  
Sbjct: 155  VGEEWSQDLHSSGR-TDLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERGEK 210

Query: 1107 MCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGP 1166
            +C   PG+ G  C + +  C     +  G C D      C C  G  G  C    D+C  
Sbjct: 211  VCN--PGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYC----DEC-- 257

Query: 1167 GPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC-RSGACHAAHTRDCLQD 1225
                   P CLH GTC      ++C C  G+ GL C  D+N C     C    T  C   
Sbjct: 258  ----IRYPGCLH-GTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGAT--CTNT 307

Query: 1226 PGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPR 1285
              G + C C  G++G  C+  +  C+  PC++GG C          +++C C   F+G  
Sbjct: 308  GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN-----SYSCTCPPGFYGKI 362

Query: 1286 CERVARSCRELQCPVGVPCQQTPRGP-RCACPPGLSGPSCRSFPGSPPGASNASCAAAPC 1344
            CE  A +C +  C  G  C  +P G   C CP G SG +C              C+++PC
Sbjct: 363  CELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK--------KIDYCSSSPC 414

Query: 1345 LHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRE 1404
             +G  C    L   + C C  G++G  C                         D   D +
Sbjct: 415  SNGAKC--VDLGDAYLCRCQAGFSGRHC-------------------------DDNVD-D 446

Query: 1405 CNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRE 1464
            C S  C  +GG C   V D    C      R          CS+P    ++  CH G   
Sbjct: 447  CASSPCA-NGGTCRDGVNDFSCTCPPGYTGR---------NCSAPVSRCEHAPCHNGA-- 494

Query: 1465 RTCNPVYEKY---CADHFADGRC 1484
             TC+    +Y   CA  +    C
Sbjct: 495  -TCHERGHRYVCECARGYGGPNC 516


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  266 bits (680), Expect = 2e-70
 Identities = 239/795 (30%), Positives = 302/795 (37%), Gaps = 180/795 (22%)

Query: 144 CSCPPGYQGRSCRSDVDECRV------------GEPCRHGGTC----------------L 175
           C CPPG +     S+V   RV             E C  GG C                 
Sbjct: 85  CGCPPGTEPPVLASEVQALRVRLEILEELVKGLKEQCT-GGCCPASAQAGTGQTDVRTLC 143

Query: 176 NTPGSF-----RCQCPAGYTGPLCENPA---VPCAPSPCRNGG---TCRQSGDLTYD-CA 223
           +  G F      C C  G+ GP C +P    +P +  P  +G     C   G      C 
Sbjct: 144 SLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCV 203

Query: 224 CLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPN 283
           C PG+ G +C      CPG  C   G CV GV    C C   ++G  C++     +  P 
Sbjct: 204 CFPGYTGPSC--GWPSCPGD-CQGRGRCVQGV----CVCRAGFSGPDCSQ-----RSCPR 251

Query: 284 ACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMG 343
            C   G C     G  CVC  G+TG       DDC    C  G +   R  +  C C  G
Sbjct: 252 GCSQRGRC----EGGRCVCDPGYTG-------DDCGMRSCPRGCSQRGRCENGRCVCNPG 300

Query: 344 KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANP-- 401
            TG  C +        C +   C     +GR  C C PG+TG       ++C   + P  
Sbjct: 301 YTGEDCGVRSC--PRGCSQRGRCK----DGR--CVCDPGYTG-------EDCGTRSCPWD 345

Query: 402 CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGF 461
           C   GRCV+ +    C C  GYTG  C T         CR +  C D      CIC  G+
Sbjct: 346 CGEGGRCVDGR----CVCWPGYTGEDCST---RTCPRDCRGRGRCEDG----ECICDTGY 394

Query: 462 TGTYCEVDIDECQSSP--CVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNG 519
           +G  C V     +S P  C   G C+D      C C  G++G+ C           CR  
Sbjct: 395 SGDDCGV-----RSCPGDCNQRGRCEDG----RCVCWPGYTGTDCG---SRACPRDCRGR 442

Query: 520 AKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRC 579
            +C    +   C C  G+ G  C   V  C  D    GRC  G     C C PGYTG  C
Sbjct: 443 GRC----ENGVCVCNAGYSGEDC--GVRSCPGDCRGRGRCESG----RCMCWPGYTGRDC 492

Query: 580 ESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCT-----FGVC 634
            ++   C    CR  G+C+D      C C  G TG       +DC S  C       G+C
Sbjct: 493 GTRA--CPGD-CRGRGRCVD----GRCVCNPGFTG-------EDCGSRRCPGDCRGHGLC 538

Query: 635 RDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP 694
            DG+    CVC  G++G  C+     C    C   G C+DG    RC+C  G     C  
Sbjct: 539 EDGV----CVCDAGYSGEDCST--RSCPGG-CRGRGQCLDG----RCVCEDGYSGEDC-- 585

Query: 695 PSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM 754
               C ++   HG+C D      C+C  G+    CS       C S  C   G C     
Sbjct: 586 GVRQCPNDCSQHGVCQDGV----CICWEGYVSEDCSIR----TCPSN-CHGRGRCEEG-- 634

Query: 755 GFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRC-QQDVDE 813
              C C PG  G  C   +   P  C   GRC        VC C  G+ G  C Q++   
Sbjct: 635 --RCLCDPGYTGPTC--ATRMCPADCRGRGRCVQG-----VCLCHVGYGGEDCGQEEPPA 685

Query: 814 CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSC 873
            A P  CGP  +C   AG   C C  G+ GP C   I  C P  C   G C DG    SC
Sbjct: 686 SACPGGCGPRELCR--AG--QCVCVEGFRGPDC--AIQTC-PGDCRGRGECHDG----SC 734

Query: 874 SCLPGFAGPRCARDV 888
            C  G+AG  C  +V
Sbjct: 735 VCKDGYAGEDCGEEV 749



 Score =  261 bits (668), Expect = 4e-69
 Identities = 247/836 (29%), Positives = 310/836 (37%), Gaps = 212/836 (25%)

Query: 175 LNTPGSFRCQCPAGYTGPLCENPA-------------VPCAPSPCRNGGTC---RQSGDL 218
           +N P S  C CP G   P+  +               V      C  GG C    Q+G  
Sbjct: 77  INLPPSTGCGCPPGTEPPVLASEVQALRVRLEILEELVKGLKEQC-TGGCCPASAQAGTG 135

Query: 219 TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278
             D   L              C  H   +   C        C C P W G  C++  D  
Sbjct: 136 QTDVRTL--------------CSLHGVFDLSRC-------TCSCEPGWGGPTCSDPTD-A 173

Query: 279 QLQPNA-----------CHNGGTCFNTLGGHSCVCVNGWTGESCS--------QNIDDCA 319
           ++ P++           C++ G C        CVC  G+TG SC         Q    C 
Sbjct: 174 EIPPSSPPSASGSCPDDCNDQGRCVR----GRCVCFPGYTGPSCGWPSCPGDCQGRGRCV 229

Query: 320 TAVC-----FHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGR 374
             VC     F G  C  R      +CP G                C +   C+     GR
Sbjct: 230 QGVCVCRAGFSGPDCSQR------SCPRG----------------CSQRGRCE----GGR 263

Query: 375 AICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNE 434
             C C PG+TG  C   +  C  G   C   GRC N +    C C  GYTG  C   V  
Sbjct: 264 --CVCDPGYTGDDC--GMRSCPRG---CSQRGRCENGR----CVCNPGYTGEDC--GVRS 310

Query: 435 CLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSP--CVNGGVCKDRVNGFS 492
           C  G C  +  C D      C+C  G+TG  C       +S P  C  GG C D      
Sbjct: 311 CPRG-CSQRGRCKDG----RCVCDPGYTGEDCGT-----RSCPWDCGEGGRCVDG----R 356

Query: 493 CTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPD 552
           C C  G++G  C           CR   +C D     EC C  G+ G  C   V  C  D
Sbjct: 357 CVCWPGYTGEDCS---TRTCPRDCRGRGRCEDG----ECICDTGYSGDDC--GVRSCPGD 407

Query: 553 PCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGT 612
               GRC DG     C C PGYTGT C S+   C  + CR  G+C    +  +C C +G 
Sbjct: 408 CNQRGRCEDG----RCVCWPGYTGTDCGSRA--C-PRDCRGRGRC----ENGVCVCNAGY 456

Query: 613 TGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSC 672
           +G +C V    C  +    G C  G     C+C PG+TG  C           C   G C
Sbjct: 457 SGEDCGVR--SCPGDCRGRGRCESG----RCMCWPGYTGRDCG---TRACPGDCRGRGRC 507

Query: 673 VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS 732
           VDG    RC+C PG     C   S  C  +   HG+C D      CVC+ G+SG  CS  
Sbjct: 508 VDG----RCVCNPGFTGEDC--GSRRCPGDCRGHGLCEDGV----CVCDAGYSGEDCSTR 557

Query: 733 LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQ 792
               +C    CR  G C  DG    C C  G  G  C +     PN C   G C+     
Sbjct: 558 ----SCPG-GCRGRGQC-LDG---RCVCEDGYSGEDCGVRQ--CPNDCSQHGVCQDG--- 603

Query: 793 LPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDIND 852
             VC C +G+    C   +  C  P+ C   G C        C C  GYTGP+C   +  
Sbjct: 604 --VCICWEGYVSEDC--SIRTC--PSNCHGRGRCE----EGRCLCDPGYTGPTCATRM-- 651

Query: 853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP--CGPGTCTDHVASFTC 910
           C P  C   G C  GV    C C  G+ G  C ++     + P  CGP    +   +  C
Sbjct: 652 C-PADCRGRGRCVQGV----CLCHVGYGGEDCGQEEPPASACPGGCGP---RELCRAGQC 703

Query: 911 TCPPGYGGFHCEQDLPDCS----PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962
            C  G+ G       PDC+    P  C   G C DG    SC+C+ GY G  C  E
Sbjct: 704 VCVEGFRG-------PDCAIQTCPGDCRGRGECHDG----SCVCKDGYAGEDCGEE 748



 Score =  236 bits (603), Expect = 1e-61
 Identities = 213/737 (28%), Positives = 259/737 (35%), Gaps = 176/737 (23%)

Query: 718  CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDG------MGFHCTCPPGVQGRQCEL 771
            C CEPGW GP CS     +   S P  A G+C  D       +   C C PG  G  C  
Sbjct: 156  CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGW 215

Query: 772  LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAG 831
              P  P  C+  GRC        VC C  G+ GP C Q     + P  C   G C     
Sbjct: 216  --PSCPGDCQGRGRCVQG-----VCVCRAGFSGPDCSQR----SCPRGCSQRGRCEG--- 261

Query: 832  SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC 891
               C C  GYTG  C   +  C P  C   G C++G     C C PG+ G  C   V  C
Sbjct: 262  -GRCVCDPGYTGDDCG--MRSC-PRGCSQRGRCENG----RCVCNPGYTGEDCG--VRSC 311

Query: 892  LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCR 951
                   G C D      C C PGY G  C      C P  C  GG CVDG     C+C 
Sbjct: 312  PRGCSQRGRCKDG----RCVCDPGYTGEDC--GTRSC-PWDCGEGGRCVDG----RCVCW 360

Query: 952  PGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQN 1011
            PGYTG  C     P   R C   G C        C C   ++G  C   V  C    C  
Sbjct: 361  PGYTGEDCSTRTCP---RDCRGRGRCEDGE----CICDTGYSGDDCG--VRSCPGD-CNQ 410

Query: 1012 GGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV 1071
             GRC      C+C PG++G  C  R+ P             + C+  G+C     +  CV
Sbjct: 411  RGRCED--GRCVCWPGYTGTDCGSRACP-------------RDCRGRGRC----ENGVCV 451

Query: 1072 CPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
            C  G +G  C     P     C+  G C        C C PGY G +C           C
Sbjct: 452  CNAGYSGEDCGVRSCP---GDCRGRGRCESGR----CMCWPGYTGRDCGT---RACPGDC 501

Query: 1132 QHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCG----PGPPLDSGPRCLHNGTCVDLVG 1187
            +  G C+D      C C PG  G       +DCG    PG        C  +G C D V 
Sbjct: 502  RGRGRCVD----GRCVCNPGFTG-------EDCGSRRCPGD-------CRGHGLCEDGV- 542

Query: 1188 GFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVL 1247
               C C  GY+G  C      C  G C       CL       RC+C  G+SG  C    
Sbjct: 543  ---CVCDAGYSGEDCST--RSC-PGGCRGRG--QCLDG-----RCVCEDGYSGEDCGVRQ 589

Query: 1248 SPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQT 1307
             P +   C   G C+            C C + +       V+  C    CP     +  
Sbjct: 590  CPND---CSQHGVCQDG---------VCICWEGY-------VSEDCSIRTCPSNCHGRGR 630

Query: 1308 PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCL----HGGS-------------- 1349
                RC C PG +GP+C +            C    CL    +GG               
Sbjct: 631  CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPG 690

Query: 1350 -CRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSP 1408
             C P  L    +C C +G+ GP C                  A Q   GD R   EC+  
Sbjct: 691  GCGPRELCRAGQCVCVEGFRGPDC------------------AIQTCPGDCRGRGECHDG 732

Query: 1409 GC----GWDGGDCSLSV 1421
             C    G+ G DC   V
Sbjct: 733  SCVCKDGYAGEDCGEEV 749



 Score =  236 bits (602), Expect = 2e-61
 Identities = 205/717 (28%), Positives = 262/717 (36%), Gaps = 171/717 (23%)

Query: 65  CLCPPGWVGERC------------------QLEDPCHS---------------------- 84
           C C PGW G  C                     D C+                       
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGW 215

Query: 85  ----GPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDG 140
               G C GRG C   V        C C  GF GPDCS         C+   RC  G   
Sbjct: 216 PSCPGDCQGRGRCVQGV--------CVCRAGFSGPDCS--QRSCPRGCSQRGRCEGG--- 262

Query: 141 RFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200
              C C PGY G  C   +  C  G  C   G C N     RC C  GYTG  C    V 
Sbjct: 263 --RCVCDPGYTGDDC--GMRSCPRG--CSQRGRCENG----RCVCNPGYTGEDC---GVR 309

Query: 201 CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNC 260
             P  C   G C+        C C PG+ G++C      CP   C  GG CVDG     C
Sbjct: 310 SCPRGCSQRGRCKDG-----RCVCDPGYTGEDC--GTRSCPWD-CGEGGRCVDG----RC 357

Query: 261 QCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCAT 320
            C P +TG+ C+      +  P  C   G C +      C+C  G++G       DDC  
Sbjct: 358 VCWPGYTGEDCS-----TRTCPRDCRGRGRCED----GECICDTGYSG-------DDCGV 401

Query: 321 AVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCP 380
             C        R     C C  G TG        C S  C  D        NG  +C C 
Sbjct: 402 RSCPGDCNQRGRCEDGRCVCWPGYTG------TDCGSRACPRDCRGRGRCENG--VCVCN 453

Query: 381 PGFTGGACDQDVDECSIGANP--CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG 438
            G++G       ++C + + P  C   GRC + +    C C  GYTG  C T       G
Sbjct: 454 AGYSG-------EDCGVRSCPGDCRGRGRCESGR----CMCWPGYTGRDCGT---RACPG 499

Query: 439 PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498
            CR +  C+D      C+C  GFTG  C      C    C   G+C+D V    C C +G
Sbjct: 500 DCRGRGRCVDG----RCVCNPGFTGEDC--GSRRCPGD-CRGHGLCEDGV----CVCDAG 548

Query: 499 FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558
           +SG  C           CR   +C+D      C C +G+ G  C   V  C  D   HG 
Sbjct: 549 YSGEDCS---TRSCPGGCRGRGQCLDG----RCVCEDGYSGEDC--GVRQCPNDCSQHGV 599

Query: 559 CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
           C DG+    C C  GY    C   +  C S  C   G+C    ++  C C  G TG  C 
Sbjct: 600 CQDGV----CICWEGYVSEDC--SIRTCPSN-CHGRGRC----EEGRCLCDPGYTGPTCA 648

Query: 619 VNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSP--CGEGGSCVDGE 676
             +  C ++    G C  G+    C+C  G+ G  C  E    ++ P  CG    C  G+
Sbjct: 649 TRM--CPADCRGRGRCVQGV----CLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQ 702

Query: 677 NGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSL 733
               C+C  G   P C      C  +    G C+D      CVC+ G++G  C + +
Sbjct: 703 ----CVCVEGFRGPDC--AIQTCPGDCRGRGECHDG----SCVCKDGYAGEDCGEEV 749



 Score =  191 bits (486), Expect = 5e-48
 Identities = 214/766 (27%), Positives = 255/766 (33%), Gaps = 195/766 (25%)

Query: 798  CPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP-- 855
            CP   Q    Q DV        C  HG+        +C+C  G+ GP+C    +   P  
Sbjct: 126  CPASAQAGTGQTDVRTL-----CSLHGVFD--LSRCTCSCEPGWGGPTCSDPTDAEIPPS 178

Query: 856  NPCLNGGSCQDGVGSFS------CSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFT 909
            +P    GSC D            C C PG+ GP C      C  +  G G C   V    
Sbjct: 179  SPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWP--SCPGDCQGRGRCVQGV---- 232

Query: 910  CTCPPGYGGFHCEQDLPDCSPSSCFNG----GTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
            C C  G+ G       PDCS  SC  G    G C  G     C+C PGYTG  C   + P
Sbjct: 233  CVCRAGFSG-------PDCSQRSCPRGCSQRGRCEGG----RCVCDPGYTGDDCGMRSCP 281

Query: 966  CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCP 1025
               R C   G C       RC C   +TG  C   V  C R  C   GRC      C+C 
Sbjct: 282  ---RGCSQRGRCENG----RCVCNPGYTGEDCG--VRSCPRG-CSQRGRCKD--GRCVCD 329

Query: 1026 PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV 1085
            PG++G  C  RS P               C  GG+CVD      CVC  G TG  C    
Sbjct: 330  PGYTGEDCGTRSCPWD-------------CGEGGRCVDGR----CVCWPGYTGEDCSTRT 372

Query: 1086 DPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYL 1145
             P   + C+  G C        C C  GY+GD+C   V  C    C   G C D      
Sbjct: 373  CP---RDCRGRGRCEDGE----CICDTGYSGDDC--GVRSCPGD-CNQRGRCED----GR 418

Query: 1146 CSCPPGTLGVLCEINEDDCGPGP-PLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG----- 1199
            C C PG  G        DCG    P D    C   G C + V    C C  GY+G     
Sbjct: 419  CVCWPGYTGT-------DCGSRACPRD----CRGRGRCENGV----CVCNAGYSGEDCGV 463

Query: 1200 LRCEADIN---ECRSGACHA--------AHTRDCLQDPGG-----GFRCLCHAGFSGPRC 1243
              C  D      C SG C            TR C  D  G       RC+C+ GF+G  C
Sbjct: 464  RSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDC 523

Query: 1244 QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVP 1303
             +   P +   C+  G C             C C   + G         C    CP G  
Sbjct: 524  GSRRCPGD---CRGHGLCEDG---------VCVCDAGYSG-------EDCSTRSCPGGCR 564

Query: 1304 CQQTPRGPRCACPPGLSGPSC--RSFPGSPP--------------GASNASCAAAPC--- 1344
             +      RC C  G SG  C  R  P                  G  +  C+   C   
Sbjct: 565  GRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSN 624

Query: 1345 LHG-GSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAAC--QAKRGDQRC 1401
             HG G C         RC C  G+TGP C       +     RC +  C      G + C
Sbjct: 625  CHGRGRCEEG------RCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDC 678

Query: 1402 DRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAG 1461
             +E   P     GG C      P   C A QC        C      P C          
Sbjct: 679  GQE-EPPASACPGG-CG-----PRELCRAGQCV-------CVEGFRGPDCAIQTCPGDCR 724

Query: 1462 GRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPAL 1507
            GR                  G C  G    + G+ G DC  EVP +
Sbjct: 725  GR------------------GECHDGSCVCKDGYAGEDCGEEVPTI 752



 Score =  180 bits (457), Expect = 1e-44
 Identities = 151/529 (28%), Positives = 197/529 (37%), Gaps = 125/529 (23%)

Query: 49  CANGGRCTQLPSREAACLCPPGWVGERCQLED-------------------PCHSG---- 85
           C+  GRC     ++  C+C PG+ GE C                       P ++G    
Sbjct: 315 CSQRGRC-----KDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCS 369

Query: 86  ------PCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPD 139
                  C GRG C+           C C  G+ G DC +        C    RC    D
Sbjct: 370 TRTCPRDCRGRGRCEDG--------ECICDTGYSGDDCGVRS--CPGDCNQRGRCE---D 416

Query: 140 GRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAV 199
           GR  C C PGY G  C S          CR  G C N      C C AGY+G  C    V
Sbjct: 417 GR--CVCWPGYTGTDCGSRA----CPRDCRGRGRCENGV----CVCNAGYSGEDC---GV 463

Query: 200 PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYN 259
              P  CR  G C +SG     C C PG+ G++C      CPG  C   G CVDG     
Sbjct: 464 RSCPGDCRGRGRC-ESG----RCMCWPGYTGRDCGTRA--CPGD-CRGRGRCVDG----R 511

Query: 260 CQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCA 319
           C C P +TG+ C       +  P  C   G C + +    CVC  G++GE       DC+
Sbjct: 512 CVCNPGFTGEDCGS-----RRCPGDCRGHGLCEDGV----CVCDAGYSGE-------DCS 555

Query: 320 TAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTC 379
           T  C  G     +     C C  G +G  C +      N C +  +C         +C C
Sbjct: 556 TRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQC--PNDCSQHGVCQD------GVCIC 607

Query: 380 PPGFTGGACDQDVDECSIGANP--CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLS 437
             G+         ++CSI   P  C   GRC   +    C C  GYTGP C T       
Sbjct: 608 WEGYVS-------EDCSIRTCPSNCHGRGRCEEGR----CLCDPGYTGPTCAT---RMCP 653

Query: 438 GPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497
             CR +  C+    Q  C+C  G+ G  C    +E  +S C  G   ++      C C  
Sbjct: 654 ADCRGRGRCV----QGVCLCHVGYGGEDC--GQEEPPASACPGGCGPRELCRAGQCVCVE 707

Query: 498 GFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNV 546
           GF G  C +   +     CR   +C D      C C +G+ G  C   V
Sbjct: 708 GFRGPDCAI---QTCPGDCRGRGECHDG----SCVCKDGYAGEDCGEEV 749



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 57/203 (28%), Positives = 75/203 (36%), Gaps = 47/203 (23%)

Query: 49  CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108
           C+  G C     ++  C+C  G+V E C +   C S  C GRG C+           C C
Sbjct: 594 CSQHGVC-----QDGVCICWEGYVSEDCSIRT-CPSN-CHGRGRCEEG--------RCLC 638

Query: 109 PRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDE------- 161
             G+ GP C+       + C    RC  G     +C C  GY G  C  +          
Sbjct: 639 DPGYTGPTCATR--MCPADCRGRGRCVQG-----VCLCHVGYGGEDCGQEEPPASACPGG 691

Query: 162 CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221
           C   E CR G          +C C  G+ GP C   A+   P  CR  G C         
Sbjct: 692 CGPRELCRAG----------QCVCVEGFRGPDC---AIQTCPGDCRGRGECHDGS----- 733

Query: 222 CACLPGFEGQNCEVNVDDCPGHR 244
           C C  G+ G++C   V    G R
Sbjct: 734 CVCKDGYAGEDCGEEVPTIEGMR 756



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 43/133 (32%), Positives = 53/133 (39%), Gaps = 26/133 (19%)

Query: 33  LAGPGAAAPPC---LDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHS---GP 86
           L  PG   P C   +  + C   GRC Q       CLC  G+ GE C  E+P  S   G 
Sbjct: 637 LCDPGYTGPTCATRMCPADCRGRGRCVQ-----GVCLCHVGYGGEDCGQEEPPASACPGG 691

Query: 87  CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSC 146
           C  R +C++          C C  GFRGPDC++        C     C  G      C C
Sbjct: 692 CGPRELCRAG--------QCVCVEGFRGPDCAI--QTCPGDCRGRGECHDGS-----CVC 736

Query: 147 PPGYQGRSCRSDV 159
             GY G  C  +V
Sbjct: 737 KDGYAGEDCGEEV 749


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  265 bits (678), Expect = 3e-70
 Identities = 153/452 (33%), Positives = 223/452 (49%), Gaps = 35/452 (7%)

Query: 140  GRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ-CPAGYTGPLCENPA 198
            GR   +CP G          + CR+G       +  +  G   C+ CP+G       +  
Sbjct: 996  GRMCVNCPLGTYYNLEHFTCESCRIG-------SYQDEEGQLECKLCPSGMYTEYIHSRN 1048

Query: 199  VPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDG-VNT 257
            +    + C+ G T   SG  T +   L  ++ +    +   CP     N  T   G VN 
Sbjct: 1049 ISDCKAQCKQG-TYSYSGLETCESCPLGTYQPKFGSRSCLSCPE----NTSTVKRGAVNI 1103

Query: 258  YNCQCP-PEWTGQFCTEDVDECQLQPNACH--NGGTCFNTLGGHSCVCVN--GWTGESCS 312
              C  P PE  G+F    +  C   P   +  N G  F       C+     G T  + S
Sbjct: 1104 SACGVPCPE--GKFSRSGLMPCHPCPRDYYQPNAGKAF-------CLACPFYGTTPFAGS 1154

Query: 313  QNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVN 372
            ++I +C++      A     V          +  +   +   C  NPCH    C      
Sbjct: 1155 RSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQL--- 1211

Query: 373  GRA-ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETD 431
            GR  +C CP G+TG  C+ D+DECS    PC + G C +  G F+C+C  GYTG RCE +
Sbjct: 1212 GRGYVCLCPLGYTGLKCETDIDECS--PLPCLNNGVCKDLVGEFICECPSGYTGQRCEEN 1269

Query: 432  VNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGF 491
            +NEC S PC N+  C+D +  + C C+ GF G +CE +++ECQS+PC+N  VC+D+V GF
Sbjct: 1270 INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGF 1329

Query: 492  SCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSP 551
             C CP GF G+ C  +VDEC S PC+NGA C D  + + C CA GF G+ C+ N+++C  
Sbjct: 1330 LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389

Query: 552  DPC-HHGRCVDGIASFSCACAPGYTGTRCESQ 582
            +PC +   CVD + S+SC C PG++G RCE++
Sbjct: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421



 Score =  264 bits (674), Expect = 9e-70
 Identities = 175/515 (33%), Positives = 230/515 (44%), Gaps = 100/515 (19%)

Query: 162  CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPL----CENPAVPCAPSPCRNGGTCRQSGD 217
            CR G   R G  C+N        CP G    L    CE+         CR G    + G 
Sbjct: 988  CRPGSVLR-GRMCVN--------CPLGTYYNLEHFTCES---------CRIGSYQDEEGQ 1029

Query: 218  LTYDCACLPGFEGQNCEV----NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTE 273
            L  +C   P   G   E     N+ DC          C  G  +Y+             E
Sbjct: 1030 L--ECKLCPS--GMYTEYIHSRNISDCKAQ-------CKQGTYSYSG-----------LE 1067

Query: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV 333
              + C L        GT     G  SC+        SC +N     T+    GA     +
Sbjct: 1068 TCESCPL--------GTYQPKFGSRSCL--------SCPEN-----TSTVKRGAV---NI 1103

Query: 334  ASFYCACPMGK---TGLL-CHLDDACVSNPCHEDAICDTNPVNGRAICTCPP--GFTGGA 387
            ++    CP GK   +GL+ CH        PC  D      P  G+A C   P  G T  A
Sbjct: 1104 SACGVPCPEGKFSRSGLMPCH--------PCPRDYY---QPNAGKAFCLACPFYGTTPFA 1152

Query: 388  CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETD---VNECLSGPCRNQA 444
              + + ECS  ++        V    S       G+   R E      +EC   PC N  
Sbjct: 1153 GSRSITECSSFSSTFSAAEESVVPPASL------GHIKKRHEISSQVFHECFFNPCHNSG 1206

Query: 445  TCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTC 504
            TC      + C+C  G+TG  CE DIDEC   PC+N GVCKD V  F C CPSG++G  C
Sbjct: 1207 TCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266

Query: 505  QLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGI 563
            + +++EC+S+PC N   CVD   GY C C +GF G  C+  V++C  +PC ++  C D +
Sbjct: 1267 EENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV 1326

Query: 564  ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDD 623
              F C C PG+ GTRC   VDEC SQPC++G  C D  + + C C +G TG +CE+NI++
Sbjct: 1327 GGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386

Query: 624  CASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVE 657
            C SNPC     C D +N Y C CQPGF+G  C  E
Sbjct: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421



 Score =  214 bits (544), Expect = 1e-54
 Identities = 95/226 (42%), Positives = 127/226 (56%), Gaps = 5/226 (2%)

Query: 548  DCSPDPCHH-GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLC 606
            +C  +PCH+ G C      + C C  GYTG +CE+ +DEC   PC + G C DLV +++C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255

Query: 607  RCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSP 665
             CPSG TG  CE NI++C+S+PC   G+C DG+  Y C C  GF G  C  E+NEC S+P
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315

Query: 666  CGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGW 724
            C     C D   GF C CPPG L   C      C  +PC +G  C D    FRC+C  G+
Sbjct: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375

Query: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE 770
            +G  C  ++  + C+S PCR   TC  +   + C C PG  G++CE
Sbjct: 1376 TGSHCELNI--NECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419



 Score =  203 bits (516), Expect = 2e-51
 Identities = 90/233 (38%), Positives = 127/233 (54%), Gaps = 15/233 (6%)

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
            C   G C      + C+CP G TG  CE ++D C   PC + G C+  +G ++CEC  GY
Sbjct: 1202 CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGY 1261

Query: 1115 NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGP 1174
             G  CE++++EC+S PC + G C+D VA Y C+C  G +G+ CE   ++C   P      
Sbjct: 1262 TGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP------ 1315

Query: 1175 RCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLC 1234
             CL+N  C D VGGF C CPPG+ G RC  +++EC S  C    T    +D    FRCLC
Sbjct: 1316 -CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGAT---CKDGANSFRCLC 1371

Query: 1235 HAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE 1287
             AGF+G  C+  ++ C+S PC++   C          +++C C   F G RCE
Sbjct: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELN-----SYSCKCQPGFSGKRCE 1419



 Score =  200 bits (509), Expect = 1e-50
 Identities = 134/421 (31%), Positives = 177/421 (42%), Gaps = 53/421 (12%)

Query: 702  EPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG-------TCSSDGM 754
            E C  G   D  G   C   P         S     C++Q C+ G        TC S  +
Sbjct: 1016 ESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCESCPL 1074

Query: 755  GFH---------CTCPPGVQG--RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803
            G +          +CP       R    +S C   PC  G    S  G +P   CP+ + 
Sbjct: 1075 GTYQPKFGSRSCLSCPENTSTVKRGAVNISACGV-PCPEGKFSRS--GLMPCHPCPRDYY 1131

Query: 804  GPRCQQDVDECA---GPAP-CGPHGI--CTNLAGSFSCTCHGGYTGPSC----------D 847
             P   +         G  P  G   I  C++ + +FS          S            
Sbjct: 1132 QPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISS 1191

Query: 848  QDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVA 906
            Q  ++C  NPC N G+CQ     + C C  G+ G +C  D+DEC   PC   G C D V 
Sbjct: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVG 1251

Query: 907  SFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966
             F C CP GY G  CE+++ +CS S C N G CVDGV  + C C  G+ G HC+ E + C
Sbjct: 1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311

Query: 967  LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA---YCL 1023
             S PCL+  VC     GF C C   F G +C   VD C  QPC+NG  C + GA    CL
Sbjct: 1312 QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC-KDGANSFRCL 1370

Query: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQ 1083
            C  G++G  C++    C+             C+    CVDE +S+ C C  G +G  CE 
Sbjct: 1371 CAAGFTGSHCELNINECQ----------SNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420

Query: 1084 E 1084
            E
Sbjct: 1421 E 1421



 Score =  200 bits (508), Expect = 2e-50
 Identities = 96/239 (40%), Positives = 121/239 (50%), Gaps = 15/239 (6%)

Query: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
            C   PC + GTC+    GY+C C  GY G  CE D+DEC+  PC + G C DLV  ++C 
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256

Query: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADIN 1207
            CP G  G  CE N ++C   P       CL+ G CVD V G+RCTC  G+ GL CE ++N
Sbjct: 1257 CPSGYTGQRCEENINECSSSP-------CLNKGICVDGVAGYRCTCVKGFVGLHCETEVN 1309

Query: 1208 ECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGP 1267
            EC+S  C   +   C +D  GGF C C  GF G RC   +  C SQPC++G  C+     
Sbjct: 1310 ECQSNPC--LNNAVC-EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK----- 1361

Query: 1268 GGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326
             G  +F C CA  F G  CE     C+   C     C        C C PG SG  C +
Sbjct: 1362 DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420



 Score =  198 bits (504), Expect = 4e-50
 Identities = 92/232 (39%), Positives = 125/232 (53%), Gaps = 5/232 (2%)

Query: 123  CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR 182
            C  +PC +   C     G ++C CP GY G  C +D+DEC    PC + G C +  G F 
Sbjct: 1197 CFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSP-LPCLNNGVCKDLVGEFI 1254

Query: 183  CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG 242
            C+CP+GYTG  CE     C+ SPC N G C   G   Y C C+ GF G +CE  V++C  
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCETEVNECQS 1313

Query: 243  HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC 302
            + CLN   C D V  + C+CPP + G  C ++VDEC  QP  C NG TC +      C+C
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP--CKNGATCKDGANSFRCLC 1371

Query: 303  VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDA 354
              G+TG  C  NI++C +  C + ATC D + S+ C C  G +G  C  + +
Sbjct: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423



 Score =  197 bits (502), Expect = 8e-50
 Identities = 128/434 (29%), Positives = 189/434 (43%), Gaps = 18/434 (4%)

Query: 456  ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT-CPSG-FSGSTCQLDVDECAS 513
            +C+    GTY  ++   C+S      G  +D      C  CPSG ++      ++ +C +
Sbjct: 998  MCVNCPLGTYYNLEHFTCESCRI---GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKA 1054

Query: 514  TPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPG 573
              C+ G       +  E      ++     R+   C   P +      G  + S    P 
Sbjct: 1055 Q-CKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC---PENTSTVKRGAVNISACGVPC 1110

Query: 574  YTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPS-GTTGVNCEVNIDDCASNPCTFG 632
              G    S +  C   PC       +    +   CP  GTT      +I +C+S   TF 
Sbjct: 1111 PEGKFSRSGLMPCH--PCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFS 1168

Query: 633  VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC 692
               + +     +        + +   +EC  +PC   G+C     G+ CLCP G     C
Sbjct: 1169 AAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKC 1228

Query: 693  LPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSS 751
                  C+  PC ++G+C D  G F C C  G++G RC +++  + C S PC   G C  
Sbjct: 1229 ETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENI--NECSSSPCLNKGICVD 1286

Query: 752  DGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD 810
               G+ CTC  G  G  CE  ++ C  NPC +   CE   G   +C CP G+ G RC ++
Sbjct: 1287 GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGF-LCKCPPGFLGTRCGKN 1345

Query: 811  VDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870
            VDEC    PC     C + A SF C C  G+TG  C+ +IN+C  NPC N  +C D + S
Sbjct: 1346 VDECLS-QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS 1404

Query: 871  FSCSCLPGFAGPRC 884
            +SC C PGF+G RC
Sbjct: 1405 YSCKCQPGFSGKRC 1418



 Score =  191 bits (486), Expect = 5e-48
 Identities = 135/463 (29%), Positives = 195/463 (42%), Gaps = 46/463 (9%)

Query: 760  CPPG--VQGRQCELLSPCTPNPCEHGGRCESA--------PGQLPVCSCPQGWQGPRCQ- 808
            C PG  ++GR C      T    EH   CES          GQL    CP G        
Sbjct: 988  CRPGSVLRGRMCVNCPLGTYYNLEHF-TCESCRIGSYQDEEGQLECKLCPSGMYTEYIHS 1046

Query: 809  QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGV 868
            +++ +C      G +   + L    SC   G Y      +    C  N      + + G 
Sbjct: 1047 RNISDCKAQCKQGTYSY-SGLETCESCPL-GTYQPKFGSRSCLSCPENT----STVKRGA 1100

Query: 869  GSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGG--FHCEQDLP 926
             + S   +P   G      +  C  +PC       +     C   P YG   F   + + 
Sbjct: 1101 VNISACGVPCPEGKFSRSGLMPC--HPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSIT 1158

Query: 927  DCSP-SSCFNGGT-CVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGF 984
            +CS  SS F+     V    S   + +     +   HE   C   PC + G C     G+
Sbjct: 1159 ECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHE---CFFNPCHNSGTCQQLGRGY 1215

Query: 985  RCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ-TGAY-CLCPPGWSGRLCDIRSLPCRE 1042
             C C   +TG +C+T +D CS  PC N G C    G + C CP G++G+ C+     C  
Sbjct: 1216 VCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSS 1275

Query: 1043 AAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGY 1102
            +           C   G CVD  + + C C +G  G HCE EV+ C + PC +   C   
Sbjct: 1276 SP----------CLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQ 1325

Query: 1103 MGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINED 1162
            +GG++C+C PG+ G  C  +VDEC SQPC++G +C D    + C C  G  G  CE+N +
Sbjct: 1326 VGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNIN 1385

Query: 1163 DCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEAD 1205
            +C   P       C +  TCVD +  + C C PG++G RCE +
Sbjct: 1386 ECQSNP-------CRNQATCVDELNSYSCKCQPGFSGKRCETE 1421



 Score =  186 bits (471), Expect = 3e-46
 Identities = 131/460 (28%), Positives = 180/460 (39%), Gaps = 76/460 (16%)

Query: 732  SLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL--LSPCTPNPCEHGG----- 784
            +L    CES  CR G     +G      CP G+         +S C    C+ G      
Sbjct: 1009 NLEHFTCES--CRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSG 1065

Query: 785  --RCESAP--------GQLPVCSCPQGWQG-PRCQQDVDECAGPAPCGPHGICTNLAGSF 833
               CES P        G     SCP+      R   ++  C  P P G        + S 
Sbjct: 1066 LETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEG------KFSRSG 1119

Query: 834  SCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLP-----GFAGPRCARDV 888
               CH       C +D               Q   G   C   P      FAG   +R +
Sbjct: 1120 LMPCH------PCPRDYY-------------QPNAGKAFCLACPFYGTTPFAG---SRSI 1157

Query: 889  DECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP-----DCSPSSCFNGGTCVDGV 943
             EC S      + T   A  +   P   G      ++      +C  + C N GTC    
Sbjct: 1158 TECSSF-----SSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLG 1212

Query: 944  NSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDW 1003
              + CLC  GYTG  C+ + D C   PCL+ GVC      F C C   +TG +C+  ++ 
Sbjct: 1213 RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINE 1272

Query: 1004 CSRQPCQNGGRCVQ--TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061
            CS  PC N G CV    G  C C  G+ G  C+     C+             C     C
Sbjct: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP----------CLNNAVC 1322

Query: 1062 VDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCED 1121
             D+     C CP G  G+ C + VD CL+QPC++G TC+     + C C  G+ G +CE 
Sbjct: 1323 EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCEL 1382

Query: 1122 DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINE 1161
            +++EC S PC++  +C+D +  Y C C PG  G  CE  +
Sbjct: 1383 NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQ 1422



 Score =  185 bits (469), Expect = 5e-46
 Identities = 87/227 (38%), Positives = 124/227 (54%), Gaps = 10/227 (4%)

Query: 47   SPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFS 105
            +PC N G C QL  R   CLCP G+ G +C+ + D C   PC   GVC+  V      F 
Sbjct: 1200 NPCHNSGTCQQL-GRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV----GEFI 1254

Query: 106  CRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV 164
            C CP G+ G  C    + C SSPC +   C  G  G + C+C  G+ G  C ++V+EC+ 
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAG-YRCTCVKGFVGLHCETEVNECQ- 1312

Query: 165  GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCAC 224
              PC +   C +  G F C+CP G+ G  C      C   PC+NG TC+  G  ++ C C
Sbjct: 1313 SNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK-DGANSFRCLC 1371

Query: 225  LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271
              GF G +CE+N+++C  + C N  TCVD +N+Y+C+C P ++G+ C
Sbjct: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418



 Score =  170 bits (431), Expect = 1e-41
 Identities = 89/249 (35%), Positives = 114/249 (45%), Gaps = 25/249 (10%)

Query: 1125 ECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVD 1184
            EC   PC + G+C  L   Y+C CP G  G+ CE + D+C P P       CL+NG C D
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP-------CLNNGVCKD 1248

Query: 1185 LVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244
            LVG F C CP GYTG RCE +INEC S  C     +    D   G+RC C  GF G  C+
Sbjct: 1249 LVGEFICECPSGYTGQRCEENINECSSSPC---LNKGICVDGVAGYRCTCVKGFVGLHCE 1305

Query: 1245 TVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPC 1304
            T ++ C+S PC +   C    G      F C C   F G RC +    C    C  G  C
Sbjct: 1306 TEVNECQSNPCLNNAVCEDQVG-----GFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC 1360

Query: 1305 QQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACA 1364
            +      RC C  G +G  C          +   C + PC +  +C        + C C 
Sbjct: 1361 KDGANSFRCLCAAGFTGSHCE--------LNINECQSNPCRNQATC--VDELNSYSCKCQ 1410

Query: 1365 QGWTGPRCE 1373
             G++G RCE
Sbjct: 1411 PGFSGKRCE 1419



 Score =  162 bits (411), Expect = 3e-39
 Identities = 81/189 (42%), Positives = 104/189 (55%), Gaps = 10/189 (5%)

Query: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFSC 106
            PC N G C  L   E  C CP G+ G+RC+   + C S PC  +G+C    V G A + C
Sbjct: 1239 PCLNNGVCKDLVG-EFICECPSGYTGQRCEENINECSSSPCLNKGIC----VDGVAGYRC 1293

Query: 107  RCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165
             C +GF G  C    + C S+PC + A C     G FLC CPPG+ G  C  +VDEC + 
Sbjct: 1294 TCVKGFVGLHCETEVNECQSNPCLNNAVCE-DQVGGFLCKCPPGFLGTRCGKNVDEC-LS 1351

Query: 166  EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225
            +PC++G TC +   SFRC C AG+TG  CE     C  +PCRN  TC    + +Y C C 
Sbjct: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN-SYSCKCQ 1410

Query: 226  PGFEGQNCE 234
            PGF G+ CE
Sbjct: 1411 PGFSGKRCE 1419



 Score =  113 bits (283), Expect = 2e-24
 Identities = 58/151 (38%), Positives = 78/151 (51%), Gaps = 9/151 (5%)

Query: 47   SPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFS 105
            SPC N G C    +    C C  G+VG  C+ E + C S PC    VC+  V      F 
Sbjct: 1276 SPCLNKGICVDGVAGYR-CTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV----GGFL 1330

Query: 106  CRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV 164
            C+CP GF G  C    D CLS PC +GA C  G +  F C C  G+ G  C  +++EC+ 
Sbjct: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS-FRCLCAAGFTGSHCELNINECQ- 1388

Query: 165  GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
              PCR+  TC++   S+ C+C  G++G  CE
Sbjct: 1389 SNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 44/109 (40%), Positives = 57/109 (52%), Gaps = 18/109 (16%)

Query: 205  PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP 264
            PC+NGG C++       C+C  G+ G+ CE  +   P   CLNGG CV     Y C CPP
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPICILP---CLNGGRCVA---PYQCDCPP 3524

Query: 265  EWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313
             WTG  C   V  CQ   + C NGG C      + C C++ WTG +CS+
Sbjct: 3525 GWTGSRCHTAV--CQ---SPCLNGGKCVRP---NRCHCLSSWTGHNCSR 3565



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 53/140 (37%), Positives = 64/140 (45%), Gaps = 34/140 (24%)

Query: 985  RCTCLESFTG---PQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD--IRSLP 1039
            R  CLE+ T    P C+ +     R PCQNGG C +  A C CP GW GRLC+  I  LP
Sbjct: 3453 RSVCLENGTWTSPPICRAVC----RFPCQNGGICQRPNA-CSCPEGWMGRLCEEPICILP 3507

Query: 1040 CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099
            C                 GG+CV   + + C CP G TGS C   V      PC +GG C
Sbjct: 3508 CLN---------------GGRCV---APYQCDCPPGWTGSRCHTAV---CQSPCLNGGKC 3546

Query: 1100 RGYMGGYMCECLPGYNGDNC 1119
               +    C CL  + G NC
Sbjct: 3547 ---VRPNRCHCLSSWTGHNC 3563



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 109/437 (24%), Positives = 160/437 (36%), Gaps = 83/437 (18%)

Query: 244  RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHN--GGTCFNTLGGHSCV 301
            RCL G T     +T+ CQ    W  +  +    +C L  N  H    G  F+     S  
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVS 3206

Query: 302  CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMG-KTGLLC---HLDDACVS 357
            C  G+T E    NI  C     +      +  +   C  P   + G +    +  ++ + 
Sbjct: 3207 CAEGYTFEGV--NISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTII 3264

Query: 358  NPC--------HEDAICDTNPV--NGRAICT-----CPPGFTGGACDQDVDECSIGANPC 402
              C        + + +C  N     G AIC       P  F  G  D  ++  + G N  
Sbjct: 3265 YQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKAD--IENRTTGPNVV 3322

Query: 403  EHLGRCVNTQGSFLCQCGRGYTG----PRCETD--------------------VNECLSG 438
                R  + +G     C    T     P C+ +                    V++ +S 
Sbjct: 3323 YSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSI 3382

Query: 439  PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK-------DRVNGF 491
             CR +   L   G  TC     +T T  + +   C     V   + +       D +  +
Sbjct: 3383 KCR-EGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMIT-Y 3440

Query: 492  SCTCP---SGFSGSTCQ-----LDVDECAST---PCRNGAKCVDQPDGYECRCAEGFEGT 540
            SC       GF  S C           C +    PC+NG  C  +P+   C C EG+ G 
Sbjct: 3441 SCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGIC-QRPNA--CSCPEGWMGR 3497

Query: 541  LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
            LC+  +  C     + GRCV   A + C C PG+TG+RC + V  C+S PC +GGKC   
Sbjct: 3498 LCEEPI--CILPCLNGGRCV---APYQCDCPPGWTGSRCHTAV--CQS-PCLNGGKC--- 3546

Query: 601  VDKYLCRCPSGTTGVNC 617
            V    C C S  TG NC
Sbjct: 3547 VRPNRCHCLSSWTGHNC 3563



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 43/106 (40%), Positives = 49/106 (46%), Gaps = 16/106 (15%)

Query: 167  PCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP 226
            PC++GG C   P +  C CP G+ G LCE    P    PC NGG C       Y C C P
Sbjct: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCEE---PICILPCLNGGRC----VAPYQCDCPP 3524

Query: 227  GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
            G+ G  C   V   P   CLNGG C   V    C C   WTG  C+
Sbjct: 3525 GWTGSRCHTAVCQSP---CLNGGKC---VRPNRCHCLSSWTGHNCS 3564



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 51/141 (36%), Positives = 63/141 (44%), Gaps = 23/141 (16%)

Query: 710  YDAPGGFRCVC-EPG-WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGR 767
            Y   G  R VC E G W+ P   +++ R      PC+ GG C        C+CP G  GR
Sbjct: 3446 YMLEGFLRSVCLENGTWTSPPICRAVCRF-----PCQNGGICQRPNA---CSCPEGWMGR 3497

Query: 768  QCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827
             CE   P    PC +GGRC  AP Q   C CP GW G RC   V +    +PC   G C 
Sbjct: 3498 LCE--EPICILPCLNGGRC-VAPYQ---CDCPPGWTGSRCHTAVCQ----SPCLNGGKCV 3547

Query: 828  NLAGSFSCTCHGGYTGPSCDQ 848
                   C C   +TG +C +
Sbjct: 3548 R---PNRCHCLSSWTGHNCSR 3565



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 39/108 (36%), Positives = 52/108 (48%), Gaps = 17/108 (15%)

Query: 779  PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCH 838
            PC++GG C+        CSCP+GW G  C++ +  C    PC   G C      + C C 
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPI--CI--LPCLNGGRC---VAPYQCDCP 3523

Query: 839  GGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
             G+TG  C   +  C  +PCLNGG C   V    C CL  + G  C+R
Sbjct: 3524 PGWTGSRCHTAV--CQ-SPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 39/107 (36%), Positives = 51/107 (47%), Gaps = 18/107 (16%)

Query: 127  PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCP 186
            PC +G  C   P+    CSCP G+ GR C   +  C +  PC +GG C+     ++C CP
Sbjct: 3475 PCQNGGICQ-RPNA---CSCPEGWMGRLCEEPI--CIL--PCLNGGRCV---APYQCDCP 3523

Query: 187  AGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNC 233
             G+TG  C         SPC NGG C +       C CL  + G NC
Sbjct: 3524 PGWTGSRCHTAV---CQSPCLNGGKCVRPN----RCHCLSSWTGHNC 3563



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 37/101 (36%), Positives = 50/101 (49%), Gaps = 13/101 (12%)

Query: 933  CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF 992
            C NGG C       +C C  G+ G  C+   +P    PCL+GG C A    ++C C   +
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRCVAP---YQCDCPPGW 3526

Query: 993  TGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLC 1033
            TG +C T V    + PC NGG+CV+    C C   W+G  C
Sbjct: 3527 TGSRCHTAV---CQSPCLNGGKCVRPNR-CHCLSSWTGHNC 3563



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 39/108 (36%), Positives = 48/108 (44%), Gaps = 19/108 (17%)

Query: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCR 107
            PC NGG C     R  AC CP GW+G  C  E+P    PC   G C        A + C 
Sbjct: 3475 PCQNGGIC----QRPNACSCPEGWMGRLC--EEPICILPCLNGGRC-------VAPYQCD 3521

Query: 108  CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSC 155
            CP G+ G  C        SPC +G +C V P+    C C   + G +C
Sbjct: 3522 CPPGWTGSRCH--TAVCQSPCLNGGKC-VRPN---RCHCLSSWTGHNC 3563



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 40/106 (37%), Positives = 50/106 (47%), Gaps = 15/106 (14%)

Query: 439  PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498
            PC+N   C        C C  G+ G  CE  I  C   PC+NGG C   V  + C CP G
Sbjct: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPI--C-ILPCLNGGRC---VAPYQCDCPPG 3525

Query: 499  FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544
            ++GS C   V     +PC NG KCV +P+   C C   + G  C R
Sbjct: 3526 WTGSRCHTAV---CQSPCLNGGKCV-RPN--RCHCLSSWTGHNCSR 3565



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 34/84 (40%), Positives = 43/84 (51%), Gaps = 12/84 (14%)

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
            CQ GG C   ++   C CPEG  G  CE+   P    PC +GG C   +  Y C+C PG+
Sbjct: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEE---PICILPCLNGGRC---VAPYQCDCPPGW 3526

Query: 1115 NGDNCEDDVDECASQPCQHGGSCI 1138
             G  C   V  C S PC +GG C+
Sbjct: 3527 TGSRCHTAV--CQS-PCLNGGKCV 3547



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 37/106 (34%), Positives = 47/106 (44%), Gaps = 14/106 (13%)

Query: 857  PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY 916
            PC NGG CQ      +CSC  G+ G  C   +  C+      G C   VA + C CPPG+
Sbjct: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPI--CILPCLNGGRC---VAPYQCDCPPGW 3526

Query: 917  GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962
             G  C   +     S C NGG C   V    C C   +TG +C  +
Sbjct: 3527 TGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSRK 3566



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 58/218 (26%), Positives = 78/218 (35%), Gaps = 34/218 (15%)

Query: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHG 1347
            +V   C    C     CQQ  RG  C CP G +G  C +            C+  PCL+ 
Sbjct: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCET--------DIDECSPLPCLNN 1243

Query: 1348 GSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNS 1407
            G C+   L   F C C  G+TG RCE      E S  P   +  C       RC   C  
Sbjct: 1244 GVCK--DLVGEFICECPSGYTGQRCE--ENINECSSSPCLNKGICVDGVAGYRC--TCVK 1297

Query: 1408 PGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTC 1467
               G+ G  C   V     +C++  C    NN+ C+       C      C  G     C
Sbjct: 1298 ---GFVGLHCETEV----NECQSNPC---LNNAVCEDQVGGFLC-----KCPPGFLGTRC 1342

Query: 1468 NPVYEKYCADHFADG-RCDQGCNTEEC----GWDGLDC 1500
                ++  +    +G  C  G N+  C    G+ G  C
Sbjct: 1343 GKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC 1380



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/164 (29%), Positives = 61/164 (37%), Gaps = 70/164 (42%)

Query: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGF 1189
            PCQ+GG C    A   CSCP G +G LCE          P+   P CL+ G CV     +
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---------EPICILP-CLNGGRCV---APY 3518

Query: 1190 RCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP 1249
            +C CPPG+TG RC               HT  C                           
Sbjct: 3519 QCDCPPGWTGSRC---------------HTAVC--------------------------- 3536

Query: 1250 CESQPCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCERVARS 1292
                PC +GG+C RP+          CHC   + G  C R  R+
Sbjct: 3537 --QSPCLNGGKCVRPN---------RCHCLSSWTGHNCSRKRRT 3569



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 58/217 (26%), Positives = 83/217 (38%), Gaps = 38/217 (17%)

Query: 554  CHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTT 613
            C  G  + G    +C   P  T T+  ++ ++    P  H       V+  + R      
Sbjct: 3384 CREGFLLQGHGIITCN--PDETWTQTSAKCEKISCGPPAH-------VENAIAR------ 3428

Query: 614  GVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGP-LCNVEINECASSPCGEGGSC 672
            GV+ +    D  +  C  G   +G  R  C+    +T P +C          PC  GG C
Sbjct: 3429 GVHYQYG--DMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRA----VCRFPCQNGGIC 3482

Query: 673  VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS 732
               +    C CP G +  LC     P    PC +G    AP  ++C C PGW+G RC  +
Sbjct: 3483 ---QRPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP--YQCDCPPGWTGSRCHTA 3534

Query: 733  LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC 769
            +    C+S PC  GG C        C C     G  C
Sbjct: 3535 V----CQS-PCLNGGKCVRPN---RCHCLSSWTGHNC 3563



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 35/106 (33%), Positives = 43/106 (40%), Gaps = 16/106 (15%)

Query: 285  CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGK 344
            C NGG C      ++C C  GW G  C + I       C +G  C   VA + C CP G 
Sbjct: 3476 CQNGGICQRP---NACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPGW 3526

Query: 345  TGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390
            TG  CH   A   +PC     C   P      C C   +TG  C +
Sbjct: 3527 TGSRCH--TAVCQSPCLNGGKC-VRPNR----CHCLSSWTGHNCSR 3565



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 46/139 (33%), Positives = 58/139 (41%), Gaps = 44/139 (31%)

Query: 1239 SGPRCQTVLSPCESQPCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQ 1297
            S P C+ V   C   PCQ+GG C RP+          C C + + G       R C E  
Sbjct: 3464 SPPICRAV---CRF-PCQNGGICQRPN---------ACSCPEGWMG-------RLCEEPI 3503

Query: 1298 CPVGVPCQQTPR--GP-RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSC-RPA 1353
            C   +PC    R   P +C CPPG +G  C           + +   +PCL+GG C RP 
Sbjct: 3504 CI--LPCLNGGRCVAPYQCDCPPGWTGSRC-----------HTAVCQSPCLNGGKCVRPN 3550

Query: 1354 PLAPFFRCACAQGWTGPRC 1372
                  RC C   WTG  C
Sbjct: 3551 ------RCHCLSSWTGHNC 3563



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 40/131 (30%), Positives = 52/131 (39%), Gaps = 13/131 (9%)

Query: 103  RFSCRCP----RGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS- 157
            R SC  P     GF   D       ++  C +G       D R  C+    + G S    
Sbjct: 1687 RISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLL--GDSRMFCTDNGSWNGVSPSCL 1744

Query: 158  DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT--GPLCENPAVPCAPSPCRNGGTCRQ- 214
            DVDEC VG  C    +CLN  GS+ C C   YT  G  C  P    AP    NG +  + 
Sbjct: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804

Query: 215  ---SGDLTYDC 222
                 ++T+ C
Sbjct: 1805 YTVGAEVTFSC 1815



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 41/135 (30%), Positives = 48/135 (35%), Gaps = 36/135 (26%)

Query: 1284 PRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP 1343
            P C  V R      C  G  CQ   R   C+CP G  G  C                  P
Sbjct: 3466 PICRAVCR----FPCQNGGICQ---RPNACSCPEGWMGRLCEE-----------PICILP 3507

Query: 1344 CLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDR 1403
            CL+GG C    +AP+ +C C  GWTG RC             +C R          RC  
Sbjct: 3508 CLNGGRC----VAPY-QCDCPPGWTGSRCHTAVCQSPCLNGGKCVR--------PNRC-- 3552

Query: 1404 ECNSPGCGWDGGDCS 1418
             C S    W G +CS
Sbjct: 3553 HCLS---SWTGHNCS 3564



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 796  CSCPQGWQG--PRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC 853
            C+    W G  P C  DVDECA  + C  H  C N+ GS+ C+C   YTG       N  
Sbjct: 1730 CTDNGSWNGVSPSCL-DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG----DGKNCA 1784

Query: 854  DPNPCLNGGSCQDGVGS 870
            +P  C   G+ ++G  S
Sbjct: 1785 EPIKCKAPGNPENGHSS 1801



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 27/71 (38%), Positives = 29/71 (40%), Gaps = 13/71 (18%)

Query: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCR 107
            PC NGGRC         C CPPGW G RC     C S PC   G C            C 
Sbjct: 3507 PCLNGGRCVA----PYQCDCPPGWTGSRCHTA-VCQS-PCLNGGKC-------VRPNRCH 3553

Query: 108  CPRGFRGPDCS 118
            C   + G +CS
Sbjct: 3554 CLSSWTGHNCS 3564



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 17/35 (48%), Positives = 24/35 (68%), Gaps = 1/35 (2%)

Query: 391  DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTG 425
            DVDEC++G++  EH   C+N  GS++C C   YTG
Sbjct: 1745 DVDECAVGSDCSEHAS-CLNVDGSYICSCVPPYTG 1778



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 68/294 (23%), Positives = 97/294 (32%), Gaps = 71/294 (24%)

Query: 395 CSIGANPCEHLG--RCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQ 452
           C  G + C+ +G  +C    G F C C +GY G   + +   C SG  + +         
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPE--------- 331

Query: 453 FTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF--SGSTCQLDVDE 510
                  G  G      I  C   P  N        +   C C  G+  SG TC+L V  
Sbjct: 332 -------GSPG-----GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL-VHC 378

Query: 511 CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCAC 570
            A  P  NG                 F    C+ + +      CH G   D + S    C
Sbjct: 379 PALKPPENGY----------------FIQNTCNNHFNAACGVRCHPG--FDLVGSSIILC 420

Query: 571 APGYTGTRCESQVDECRSQPC------RHGG-KCLDLVDKYLCRC---------PSGTTG 614
            P    +  ES    CR + C      +HG   C      Y   C           G+  
Sbjct: 421 LPNGLWSGSESY---CRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 615 VNCEVNID------DCASNPC-TFGVCRDG-INRYDCVCQPGFTGPLCNVEINE 660
           + C+ N         C    C TF + +D  I+ ++C  QP   G +C V   +
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQ 531



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 68/295 (23%), Positives = 93/295 (31%), Gaps = 67/295 (22%)

Query: 807  CQQDVDEC--AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQD--------------- 849
            C +  D C   G   CG H       G F C C  GY G     +               
Sbjct: 281  CDEGKDCCDRMGSCKCGTH------TGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334

Query: 850  --INDCDPNPCLNGGSCQDGVGSFSCSCLPGF--AGPRCARDVDECLSNPCG----PGTC 901
              I+ C P P  N  S         C C  G+  +G  C       L  P        TC
Sbjct: 335  GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTC 394

Query: 902  TDHV-ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
             +H  A+    C PG+        L  C P+  ++G      V +   L +P       +
Sbjct: 395  NNHFNAACGVRCHPGFDLVGSSIIL--CLPNGLWSGSESYCRVRTCPHLRQP-------K 445

Query: 961  HEADPCLSRPCLHGGVC-SAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ-- 1017
            H    C +R  L+   C  A   G+R   LE      CQ    W   +P     RCV+  
Sbjct: 446  HGHISCSTREMLYKTTCLVACDEGYR---LEGSDKLTCQGNSQWDGPEP-----RCVERH 497

Query: 1018 ------------TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQ 1060
                        +   C   P   G +C +    CR+     GV+    C   G+
Sbjct: 498  CSTFQMPKDVIISPHNCGKQPAKFGTICYV---SCRQGFILSGVKEMLRCTTSGK 549



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 67/270 (24%), Positives = 95/270 (35%), Gaps = 46/270 (17%)

Query: 920  HCEQDLPDCSPSSCFNGGTCVDGVNS--FSCLCRPGYTGAHCQHEADPCLSRPCLHGGVC 977
            HC   L D     C   G+C  G ++  F C+C  GY G   Q+E   C S     G   
Sbjct: 276  HCSY-LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPS-----GTYK 329

Query: 978  SAAHPGFRCTCL----ESFTGPQCQTLVDWCSRQPCQNGGRCV-QTGAYCLCP---PGWS 1029
                PG   +C+    E+ T P   T  + C    C+ G R   QT     CP   P  +
Sbjct: 330  PEGSPGGISSCIPCPDENHTSPPGSTSPEDC---VCREGYRASGQTCELVHCPALKPPEN 386

Query: 1030 GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG---RTGSHCEQEVD 1086
            G    I++       A  GVR    C  G   V   SS     P G    + S+C     
Sbjct: 387  GYF--IQNTCNNHFNAACGVR----CHPGFDLV--GSSIILCLPNGLWSGSESYCRVRTC 438

Query: 1087 PCLAQPCQHGGTCRGYMGGYMCECL----PGYNGDNCEDDVDECASQPCQHGGSCID--- 1139
            P L QP     +C      Y   CL     GY  +  +    +  SQ       C++   
Sbjct: 439  PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHC 498

Query: 1140 ---------LVARYLCSCPPGTLGVLCEIN 1160
                     +++ + C   P   G +C ++
Sbjct: 499  STFQMPKDVIISPHNCGKQPAKFGTICYVS 528



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 12/92 (13%)

Query: 835  CTCHGGYTG--PSCDQDINDCDP-NPCLNGGSCQDGVGSFSCSCLPGFA--GPRCARDVD 889
            CT +G + G  PSC  D+++C   + C    SC +  GS+ CSC+P +   G  CA  + 
Sbjct: 1730 CTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI- 1787

Query: 890  ECLS-----NPCGPGTCTDHVASFTCTCPPGY 916
            +C +     N    G      A  T +C  GY
Sbjct: 1788 KCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 6/74 (8%)

Query: 1084 EVDPC-LAQPCQHGGTCRGYMGGYMCECLPGYNGD--NCEDDVDECASQPCQHG---GSC 1137
            +VD C +   C    +C    G Y+C C+P Y GD  NC + +   A    ++G   G  
Sbjct: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804

Query: 1138 IDLVARYLCSCPPG 1151
              + A    SC  G
Sbjct: 1805 YTVGAEVTFSCQEG 1818



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 35/125 (28%), Positives = 44/125 (35%), Gaps = 24/125 (19%)

Query: 128 CAHGARCSVGPD-GRFLCSCPPGYQGRSCRSDVDECRVGEPCRHG-----GTCL------ 175
           C     C  G   G F C C  GY G+  + +   C  G     G      +C+      
Sbjct: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347

Query: 176 --NTPGSFR---CQCPAGY--TGPLCENPAVPCAPSPCRNG----GTCRQSGDLTYDCAC 224
             + PGS     C C  GY  +G  CE    P A  P  NG     TC    +      C
Sbjct: 348 HTSPPGSTSPEDCVCREGYRASGQTCELVHCP-ALKPPENGYFIQNTCNNHFNAACGVRC 406

Query: 225 LPGFE 229
            PGF+
Sbjct: 407 HPGFD 411



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 41/156 (26%), Positives = 56/156 (35%), Gaps = 15/156 (9%)

Query: 318  CATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC----HEDAICDTNPVNG 373
            C+      G+  H R AS     P  K  L C      V NP     ++       P   
Sbjct: 1628 CSDCPRLGGSVPHLRTASEDLK-PGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCE 1686

Query: 374  RAICTCPPGFTGGACDQDVDECSIGAN---PCEHLGRCVNTQGSFLCQCGRGYTG--PRC 428
            R  C  PP    G      D+   G+     C + G  +       C     + G  P C
Sbjct: 1687 RISCGVPPPLENGF--HSADDFYAGSTVTYQCNN-GYYLLGDSRMFCTDNGSWNGVSPSC 1743

Query: 429  ETDVNECLSGP-CRNQATCLDRIGQFTCICMAGFTG 463
              DV+EC  G  C   A+CL+  G + C C+  +TG
Sbjct: 1744 -LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 64/296 (21%), Positives = 83/296 (28%), Gaps = 75/296 (25%)

Query: 541 LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
           LCD   D C  D     +C      F C C  GY G   + +   C S   +        
Sbjct: 280 LCDEGKDCC--DRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYK-------- 329

Query: 601 VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDG-INRYDCVCQPGFTGPLCNVEIN 659
                   P G+ G      I  C   P        G  +  DCVC+ G+       E+ 
Sbjct: 330 --------PEGSPG-----GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELV 376

Query: 660 ECASSPCGEGGSCVDG--ENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFR 717
            C +    E G  +     N F   C     P                    +D  G   
Sbjct: 377 HCPALKPPENGYFIQNTCNNHFNAACGVRCHPG-------------------FDLVGSSI 417

Query: 718 CVCEPG--WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC 775
            +C P   WSG      +       QP     +CS+  M +  TC               
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------------ 465

Query: 776 TPNPCEHGGRCESAPGQLPVCSCPQGWQG--PRC--------QQDVDECAGPAPCG 821
               C+ G R E +      C     W G  PRC        Q   D    P  CG
Sbjct: 466 ----CDEGYRLEGS--DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCG 515



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 48/200 (24%), Positives = 67/200 (33%), Gaps = 58/200 (29%)

Query: 125  SSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ 184
            S P    A   + P  +    C PG+Q            VG P ++   CLN        
Sbjct: 1637 SVPHLRTASEDLKPGSKVNLFCDPGFQ-----------LVGNPVQY---CLNQ------- 1675

Query: 185  CPAGYTGPLCENPAVPCA-PSPCRNGGTCRQS----GDLTYDCACLPGFEGQNCEVNVDD 239
                +T PL     + C  P P  NG            +TY C                 
Sbjct: 1676 --GQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQC----------------- 1716

Query: 240  CPGHRCLNGGTCVDGVNTYNCQCPPEWTG--QFCTEDVDECQLQPNACHNGGTCFNTLGG 297
                   N G  + G +   C     W G    C  DVDEC +  + C    +C N  G 
Sbjct: 1717 -------NNGYYLLGDSRMFCTDNGSWNGVSPSCL-DVDECAVGSD-CSEHASCLNVDGS 1767

Query: 298  HSCVCVNGWTGE--SCSQNI 315
            + C CV  +TG+  +C++ I
Sbjct: 1768 YICSCVPPYTGDGKNCAEPI 1787



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)

Query: 1122 DVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLG 1154
            DVDECA    C    SC+++   Y+CSC P   G
Sbjct: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 8/90 (8%)

Query: 493  CTCPSGFSG-STCQLDVDECA-STPCRNGAKCVDQPDGYECRCAEGF--EGTLCDRNVDD 548
            CT    ++G S   LDVDECA  + C   A C++    Y C C   +  +G  C   +  
Sbjct: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789

Query: 549  CSPDPCHHGRCVDGI----ASFSCACAPGY 574
             +P    +G     I    A  + +C  GY
Sbjct: 1790 KAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 14/30 (46%), Positives = 17/30 (56%), Gaps = 4/30 (13%)

Query: 47   SPCANGGRCTQLPSREAACLCPPGWVGERC 76
            SPC NGG+C + P+R   C C   W G  C
Sbjct: 3538 SPCLNGGKCVR-PNR---CHCLSSWTGHNC 3563



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 14/107 (13%)

Query: 629  CTFGVCRDGINRYDCVCQPGFTG--PLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPP 685
            C  G    G +R  C     + G  P C ++++ECA  S C E  SC++ +  + C C P
Sbjct: 1716 CNNGYYLLGDSRMFCTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774

Query: 686  G--------SLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGW 724
                     + P  C  P +P      S G  Y         C+ G+
Sbjct: 1775 PYTGDGKNCAEPIKCKAPGNP--ENGHSSGEIYTVGAEVTFSCQEGY 1819



 Score = 31.6 bits (70), Expect = 9.5
 Identities = 13/34 (38%), Positives = 20/34 (58%), Gaps = 2/34 (5%)

Query: 545  NVDDCS--PDPCHHGRCVDGIASFSCACAPGYTG 576
            +VD+C+   D   H  C++   S+ C+C P YTG
Sbjct: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  256 bits (654), Expect = 2e-67
 Identities = 265/998 (26%), Positives = 367/998 (36%), Gaps = 226/998 (22%)

Query: 392  VDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE---TDVNECLSGPCRNQATCLD 448
            +D C+ GA      G CVN    + C C  GY     +   TD NECL  PC+ +  C++
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 449  RIGQFTCICMAGFT-----GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF---S 500
            R+G ++C C  G+T      T    DI+EC+     +GG C +    + C C  G+    
Sbjct: 905  RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964

Query: 501  GSTCQLDVDECASTPCRNGAKCVDQPDGYEC-RCAEGFEGTLCDR-NVDDC-SPDPCHHG 557
               CQ D++EC         +CV+ P  Y C  C EG+ G      +V++C +P  C HG
Sbjct: 965  KGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG 1023

Query: 558  RCVDGIASFSCACAPGYTGTRCES---QVDECRSQPCRHGGKCLDLVDKYLCR------- 607
            +C +   SF C+C  GY  T  E     VDEC S+     G CL+    + C        
Sbjct: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083

Query: 608  -------------------CPSGTT---------------------GVNCEVNIDDCAS- 626
                               CPSG                       G +CE ++D+C   
Sbjct: 1084 VNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDP 1142

Query: 627  -NPCTFGVCRDGINRYDCVCQPGF---TGPLCNVEINECASSP-CGEGGSCVDGENGFRC 681
             + C  G C++ +  Y C+C  GF    G +C  ++NEC     C   G C++    F C
Sbjct: 1143 QSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFFC 1201

Query: 682  LCPPGSLPP----LCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWS-GPRCSQSLARD 736
            LC PG +       C         +PC  G C +  G F C+CE G+   P   + +  D
Sbjct: 1202 LCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDID 1261

Query: 737  ACESQPCRAGGT--CSSDGMGFHCT--CPPGVQ---GRQCELLSPCTPNP-CEHGGRCES 788
             CE       GT  C +    + C   C PG        C  +  C  +  C   G C++
Sbjct: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDN 1321

Query: 789  APGQLPVCSCPQGWQ----GPRCQQDVDECAGP-APCGPHGICTNLAGSFSCTCHG---- 839
              G    C C QG++    G  C  DV+EC    A CG   +C N+ GSF C C      
Sbjct: 1322 TDGSFR-CLCDQGFEISPSGWDCV-DVNECELMLAVCGA-ALCENVEGSFLCLCASDLEE 1378

Query: 840  -----------GYTGPSCDQ-DINDCDPNP----CLNG----GSCQDGVG----SFSCSC 875
                       G  G S  +    D  P P    C +G      C   +G       C C
Sbjct: 1379 YDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCC 1438

Query: 876  LPGFA-----------------------------------GPRCARDVDECL---SNPCG 897
              G +                                   G     D DEC+      C 
Sbjct: 1439 TQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCP 1498

Query: 898  PGTCTDHVASFTCTCPPG--YGGFH--CEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPG 953
             G C + V  + C C PG  Y   H  CE D  +C   +C NG  CV+   SF C C P 
Sbjct: 1499 NGRCLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACENG-ECVNTEGSFHCFCSPP 1556

Query: 954  YT----GAHCQHEADPCLSRPC--LHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ 1007
             T       C +        P   +H  +C        C+  E   G +  T  + C   
Sbjct: 1557 LTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCS--EPLRGHRT-TYTECC--- 1610

Query: 1008 PCQNGGRCVQTGAYCLCPPGWS---GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDE 1064
             CQ+G    Q  A  LCPP  S    +LC++  +   EA  + GV      + G      
Sbjct: 1611 -CQDGEAWSQQCA--LCPPRSSEVYAQLCNVARI---EAEREAGVHFRPGYEYGP---GP 1661

Query: 1065 DSSHYCVC-PEG-------------------RTGSHCEQEVDPCLAQPCQHGGTCRGYMG 1104
            D  HY +  P+G                    T  H      P L  P Q       Y+ 
Sbjct: 1662 DDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRT-PILESPLQPSELQPHYVA 1720

Query: 1105 GYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPG----TLGVLC-EI 1159
             +  E   G+ G   E    EC        G C+ +   Y C C  G       + C ++
Sbjct: 1721 SHP-EPPAGFEGLQAE----ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDV 1775

Query: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY 1197
            NE D   GP +     C+H G C +  G +RC C PGY
Sbjct: 1776 NECDDLNGPAV----LCVH-GYCENTEGSYRCHCSPGY 1808



 Score =  244 bits (622), Expect = 9e-64
 Identities = 282/1020 (27%), Positives = 405/1020 (39%), Gaps = 207/1020 (20%)

Query: 29   LLLLLAGPGAAAPPCLDGSPCANG-GRCTQLPSREAACLCPPGWV----GERCQLEDPCH 83
            +L+ L+ PG     C  G+    G G C  LP     C+C PG+        C  ++ C 
Sbjct: 836  VLVTLSTPGIDR--CAAGATNVCGPGTCVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL 892

Query: 84   SGPCAGRGVCQSSVVAGTARFSCRCPRGF------RGPDCSLPDPCLSSPCAHGARCSVG 137
              PC G+G C + V      +SC C  G+         +C   + C       G +C+  
Sbjct: 893  RDPCKGKGRCINRV----GSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCT-N 947

Query: 138  PDGRFLCSCPPGY---QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRC-QCPAGYTGP- 192
             +G + C C  GY   +   C+ D++ECR    C   G C+N+PGS+ C  C  GY G  
Sbjct: 948  TEGSYHCECDQGYIMVRKGHCQ-DINECRHPGTC-PDGRCVNSPGSYTCLACEEGYRGQS 1005

Query: 193  -LCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE---VNVDDCPGHRCLNG 248
              C +      P  C +G      G  ++ C+C  G+E  + E    +VD+C        
Sbjct: 1006 GSCVDVNECLTPGVCAHGKCTNLEG--SFRCSCEQGYEVTSDEKGCQDVDECASRASCPT 1063

Query: 249  GTCVDGVNTYNCQCPPE--WTGQFCT--EDVDECQLQPNACHNGGTCFNTLGGHSCV-CV 303
            G C++   ++ C       W  +  T  ED+DEC   P  C + G C NT G  SC  C 
Sbjct: 1064 GLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPS-GVCTNTAGSFSCKDCD 1121

Query: 304  NGW----TGESCSQNIDDC--ATAVCFHGATCHDRVASFYCACPMG---KTGLLCHLDDA 354
             G+     G+SC +++D+C    + C  G  C + V S+ C CP G     G +C   + 
Sbjct: 1122 GGYRPSPLGDSC-EDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLANGTVCEDVNE 1179

Query: 355  CVSNP-CHEDAICDTNPVNGRAICTCPPGFT---GGACDQDVDECSIGANPCEHLGRCVN 410
            C+    C     C  +  +G   C C PGF    GG   QDVDEC+   +PC   G CVN
Sbjct: 1180 CMGEEHCAPHGECLNS--HGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPCVG-GHCVN 1235

Query: 411  TQGSFLCQCGRGYTGPRCET----DVNEC--LSGPCRNQATCLDRIGQFTCI--CMAGF- 461
            T+GSF C C  G+  P  E+    D++EC     P      C +  G + C+  C  GF 
Sbjct: 1236 TEGSFNCLCETGFQ-PSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294

Query: 462  --TGTYCEVDIDEC-QSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECAST 514
                  C +DIDEC   + C + G C +    F C C  GF    SG  C +DV+EC   
Sbjct: 1295 MAPNGDC-IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELM 1352

Query: 515  PCRNGAKCVDQPDG-YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPG 573
                GA   +  +G + C CA   E    D     C P     G+ +    +   A AP 
Sbjct: 1353 LAVCGAALCENVEGSFLCLCASDLEE--YDAQEGHCRPRGA-GGQSMSEAPTGDHAPAPT 1409

Query: 574  ----YTGTR----CES-------QVDECRSQPCRHGGKCLDLVD-----KYLCRCPSG-- 611
                Y+G +    C S       Q + C +Q    G  C DL       ++   CPSG  
Sbjct: 1410 RMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDAC-DLCPSEDSAEFSEICPSGKG 1468

Query: 612  --------TTGVNCEVNIDDC---ASNPCTFGVCRDGINRYDCVCQPGF----TGPLCNV 656
                    T G     + D+C       C  G C + +  Y C+C PGF    +   C  
Sbjct: 1469 YIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCE- 1527

Query: 657  EINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP----------------PSHPCA 700
            + +EC    C E G CV+ E  F C C     PPL L                 P H   
Sbjct: 1528 DHDECQDLAC-ENGECVNTEGSFHCFCS----PPLTLDLSQQRCMNSTSSTEDLPDHDIH 1582

Query: 701  HEPC----SHGICYDAPGGFR-----CVCEPG--WS------GPRCSQSLAR--DACESQ 741
             + C    ++ +C +   G R     C C+ G  WS       PR S+  A+  +    +
Sbjct: 1583 MDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIE 1642

Query: 742  PCRAGGT---------CSSDGMGFHCTCPPGVQ-----GRQCELLSPCTPNPCEHGG--- 784
              R  G             D + +    P G       G +  +  P  PN   H     
Sbjct: 1643 AEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRT 1702

Query: 785  ---RCESAPGQLP---VCSCPQ---GWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
                    P +L    V S P+   G++G       +EC     C  +G C  +   ++C
Sbjct: 1703 PILESPLQPSELQPHYVASHPEPPAGFEG----LQAEECGILNGC-ENGRCVRVREGYTC 1757

Query: 836  TCHGGYTGPSCDQ---DINDCDPNPCLNG-------GSCQDGVGSFSCSCLPGF---AGP 882
             C  G+   +      D+N+CD    LNG       G C++  GS+ C C PG+   AGP
Sbjct: 1758 DCFEGFQLDAAHMACVDVNECDD---LNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGP 1814



 Score =  239 bits (610), Expect = 2e-62
 Identities = 269/1017 (26%), Positives = 381/1017 (37%), Gaps = 168/1017 (16%)

Query: 369  NPVNGRAICTCPPGFTGGACD--QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY--- 423
            +PV       CP G+        QD++EC +    C+    CVNT+GS+LC C  G    
Sbjct: 598  SPVIENGQLECPQGYKRLNLTHCQDINEC-LTLGLCKD-AECVNTRGSYLCTCRPGLMLD 655

Query: 424  -TGPRCETD-VNECLSGPCRNQ---ATCLDRIGQFTC--ICMAGFTGTYCEVDIDECQSS 476
             +  RC +D     L G C       TC   + Q     IC     G        EC+  
Sbjct: 656  PSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWG---SECEKC 712

Query: 477  PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV---------DECASTPCRNGAKCVDQPD 527
            P             F   CP+G   +    D+         +E A  P   G +      
Sbjct: 713  PLPG-------TEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALP 765

Query: 528  GYECRCAEGF-------EGTLCDRN---VDDCSPDPCHHGRCVDGIASFSCACAPGYTGT 577
            G   R             GT+ D+        +    H    V G A+       G    
Sbjct: 766  GPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEI 825

Query: 578  RCESQ--------------VDECRSQPCR--HGGKCLDLVDKYLCRCPSG----TTGVNC 617
            + E                +D C +        G C++L D Y C C  G     +   C
Sbjct: 826  QEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYC 885

Query: 618  EVNIDDCASNPCTF-GVCRDGINRYDCVCQPGFTGPLCNV-----EINECASSPCGEGGS 671
              + ++C  +PC   G C + +  Y C C PG+T           +INEC       GG 
Sbjct: 886  -TDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQ 944

Query: 672  CVDGENGFRCLCPPGSLPPLCLPPSH-----PCAHE-PCSHGICYDAPGGFRCV-CEPGW 724
            C + E  + C C  G +    +   H      C H   C  G C ++PG + C+ CE G+
Sbjct: 945  CTNTEGSYHCECDQGYI---MVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY 1001

Query: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQ----GRQCELLSPCTPNPC 780
             G +    +  + C +    A G C++    F C+C  G +     + C+ +  C     
Sbjct: 1002 RG-QSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS 1060

Query: 781  EHGGRCESAPGQLPVCSCPQGW----QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCT 836
               G C +  G     +C  G+     G  C+ D+DECA P  C P G+CTN AGSFSC 
Sbjct: 1061 CPTGLCLNTEGSFACSACENGYWVNEDGTACE-DLDECAFPGVC-PSGVCTNTAGSFSCK 1118

Query: 837  -CHGGYT----GPSCDQDINDC-DPNPCLNGGSCQDGVGSFSCSCLPGF--AGPRCARDV 888
             C GGY     G SC+ D+++C DP     GG C++ VGS+ C C  GF  A      DV
Sbjct: 1119 DCDGGYRPSPLGDSCE-DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDV 1177

Query: 889  DECLSNP-CGP-GTCTDHVASFTCTCPPGY----GGFHCEQDLPDCSPSSCFNGGTCVDG 942
            +EC+    C P G C +   SF C C PG+    GG  C QD+ +C+ +    GG CV+ 
Sbjct: 1178 NECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSC-QDVDECATTDPCVGGHCVNT 1236

Query: 943  VNSFSCLCRPGYTGAHCQHEA---DPC--LSRPCLHGGVCSAAHPGFRCT--CLESF--- 992
              SF+CLC  G+  +    E    D C     P      C  +   +RC   C   F   
Sbjct: 1237 EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA 1296

Query: 993  TGPQCQTLVDWCSRQPCQNGGRCVQT-GAY-CLC-------PPGWSG---RLCDIRSLPC 1040
                C  + +  +   C + G C  T G++ CLC       P GW       C++    C
Sbjct: 1297 PNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVC 1356

Query: 1041 REAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCR 1100
              A  +  V    LC       + D+      P G  G    +      A          
Sbjct: 1357 GAALCE-NVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYS 1415

Query: 1101 GYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLV-----ARYLCSCPPG---- 1151
            G  G   C  + G N    E     C +Q    G +C DL      A +   CP G    
Sbjct: 1416 GQKGHAPCSSVLGRNTTQAEC----CCTQGASWGDAC-DLCPSEDSAEFSEICPSGKGYI 1470

Query: 1152 ------TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLR 1201
                  T G     + D+C     +  GP    NG C++ V G+ C C PG+    +  +
Sbjct: 1471 PVEGAWTFGQTMYTDADEC-----VIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKK 1525

Query: 1202 CEADINECRSGACHAAHTRDCLQDPGGGFRCLCH----AGFSGPRCQTVLSPCESQP 1254
            CE D +EC+  AC      +C+ +  G F C C        S  RC    S  E  P
Sbjct: 1526 CE-DHDECQDLAC---ENGECV-NTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLP 1577



 Score =  186 bits (472), Expect = 2e-46
 Identities = 238/893 (26%), Positives = 322/893 (36%), Gaps = 134/893 (15%)

Query: 549  CSPDPCHHGRCVDGIASFSCACAPGYTG---TRCESQVDECRSQPCRHGGKCLDLVDKYL 605
            C+P P      V  I +    C  GY     T C+  ++EC +       +C++    YL
Sbjct: 589  CAPCPPRPASPV--IENGQLECPQGYKRLNLTHCQD-INECLTLGLCKDAECVNTRGSYL 645

Query: 606  CRCPSGTTGVNCEVNIDDCASNPCTF---GVCRDGINRYDCVCQPGFTGPLCN-VEINEC 661
            C C     G+  + +   C S+       G+C   +    C      T PL   +    C
Sbjct: 646  CTC---RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTC------TLPLAQRITKQIC 696

Query: 662  ASSPCGE--GGSC----VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG 715
              S  G+  G  C    + G   FR +CP G          H   +      +       
Sbjct: 697  CCSRVGKAWGSECEKCPLPGTEAFREICPAG----------HGYTYASSDIRLSMRKAEE 746

Query: 716  FRCVCEPGWSGPRCSQSLARDACESQPCRA-------GGTCSSDGMGFHCTCPPGVQGRQ 768
                  P   G R S +L   A E QP R         GT    G          V    
Sbjct: 747  EELARPPREQGQRSSGALPGPA-ERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAP 805

Query: 769  CELLSPCTPNPCEHGGRCESAPGQL-PVCSCPQGWQGPRCQQDVDECAGPAP--CGPHGI 825
              +    T  P    G  E    Q+ P          P     +D CA  A   CGP G 
Sbjct: 806  AWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP----GIDRCAAGATNVCGP-GT 860

Query: 826  CTNLAGSFSCTCHGGYT-GPS---CDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGF-- 879
            C NL   + C C  GY   PS   C  D N+C  +PC   G C + VGS+SC C PG+  
Sbjct: 861  CVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919

Query: 880  ----AGPRCARDVDEC-LSNPCGPGTCTDHVASFTCTCPPGY---GGFHCEQDLPDCSPS 931
                A   C +D++EC     C  G CT+   S+ C C  GY      HC QD+ +C   
Sbjct: 920  ATSGATQEC-QDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHC-QDINECRHP 977

Query: 932  SCFNGGTCVDGVNSFSCL-CRPGYTG--AHCQHEADPCLSRPCLHGGVCSAAHPGFRCTC 988
                 G CV+   S++CL C  GY G    C  + + CL+      G C+     FRC+C
Sbjct: 978  GTCPDGRCVNSPGSYTCLACEEGYRGQSGSCV-DVNECLTPGVCAHGKCTNLEGSFRCSC 1036

Query: 989  LESFTGPQ----CQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAA 1044
             + +        CQ + +  SR  C   G C+ T     C    +G   +     C +  
Sbjct: 1037 EQGYEVTSDEKGCQDVDECASRASCPT-GLCLNTEGSFACSACENGYWVNEDGTACEDLD 1095

Query: 1045 AQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG-----RTGSHCEQEVDPCL-AQPCQHGGT 1098
                     +C + G C +   S  C   +G       G  CE +VD C   Q    GG 
Sbjct: 1096 E---CAFPGVCPS-GVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDPQSSCLGGE 1150

Query: 1099 CRGYMGGYMCECLPGY---NGDNCEDDVDEC-ASQPCQHGGSCIDLVARYLCSCPPGTL- 1153
            C+  +G Y C C  G+   NG  CE DV+EC   + C   G C++    + C C PG + 
Sbjct: 1151 CKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVS 1209

Query: 1154 ---GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLRCEADI 1206
               G  C+ + D+C    P      C+  G CV+  G F C C  G+        C  DI
Sbjct: 1210 AEGGTSCQ-DVDECATTDP------CV-GGHCVNTEGSFNCLCETGFQPSPESGEC-VDI 1260

Query: 1207 NECRSGACHAAHTRDCLQDPGGGFRCL--CHAGF---SGPRCQTVLSPCESQPCQHGGQC 1261
            +EC         T  C   P G +RC+  C  GF       C  +        C   G C
Sbjct: 1261 DECEDYGDPVCGTWKCENSP-GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFC 1319

Query: 1262 RPSPGPGGGLTFTCHCAQPF----WGPRCERVARSCRELQCPVGVP-CQQTPRGPRCACP 1316
              + G     +F C C Q F     G  C  V   C  +    G   C+       C C 
Sbjct: 1320 DNTDG-----SFRCLCDQGFEISPSGWDCVDV-NECELMLAVCGAALCENVEGSFLCLCA 1373

Query: 1317 PGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTG 1369
              L     +     P GA   S + AP    G   PAP     R  C  G  G
Sbjct: 1374 SDLEEYDAQEGHCRPRGAGGQSMSEAPT---GDHAPAPT----RMDCYSGQKG 1419



 Score =  123 bits (309), Expect = 2e-27
 Identities = 147/569 (25%), Positives = 204/569 (35%), Gaps = 107/569 (18%)

Query: 975  GVCSAAHPGFRCTCLESFTGPQCQTLV---DWCSRQPCQNGGRCV-QTGAY-CLCPPGWS 1029
            G C     G+RC C   +     Q      + C R PC+  GRC+ + G+Y C C PG++
Sbjct: 859  GTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYT 918

Query: 1030 GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG----RTGSHCEQEV 1085
                 + +    +    I    +    +GGQC + + S++C C +G    R G HC Q++
Sbjct: 919  -----LATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HC-QDI 971

Query: 1086 DPCLAQPCQHGGTCRGYMGGYMC-ECLPGYNGDNCED-DVDECASQPCQHGGSCIDLVAR 1143
            + C        G C    G Y C  C  GY G +    DV+EC +      G C +L   
Sbjct: 972  NECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGS 1031

Query: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRC-LHNGTCVDLVGGFRCT-CPPGY---- 1197
            + CSC  G      E+  D+ G     +   R     G C++  G F C+ C  GY    
Sbjct: 1032 FRCSCEQGY-----EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNE 1086

Query: 1198 TGLRCEADINECR-SGACHAAHTRDCLQDPGGGFRCL-CHAGFS----GPRCQTVLSPCE 1251
             G  CE D++EC   G C +        +  G F C  C  G+     G  C+ V    +
Sbjct: 1087 DGTACE-DLDECAFPGVCPSG----VCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECED 1141

Query: 1252 SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW---GPRCERVARSCRELQCPVGVPCQQTP 1308
             Q    GG+C+ + G     ++ C C Q F    G  CE V     E  C     C  + 
Sbjct: 1142 PQSSCLGGECKNTVG-----SYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSH 1196

Query: 1309 RGPRCACPPGL----SGPSCRSFPGSPPGASNASCAAA-PCLHGGSCRPAPLAPFFRCAC 1363
                C C PG      G SC+             CA   PC+ GG C        F C C
Sbjct: 1197 GSFFCLCAPGFVSAEGGTSCQDVD---------ECATTDPCV-GGHC--VNTEGSFNCLC 1244

Query: 1364 AQGWT-GPRCEAPAAAPEVSE--EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS 1420
              G+   P         E  +  +P C    C+   G  RC   C         GDC   
Sbjct: 1245 ETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCI-- 1302

Query: 1421 VGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFA 1480
              D         C    ++  CD    S  CL                            
Sbjct: 1303 --DIDECANDTMCG---SHGFCDNTDGSFRCL---------------------------- 1329

Query: 1481 DGRCDQGCNTEECGWDGLDCASEVPALLA 1509
               CDQG      GWD +D  +E   +LA
Sbjct: 1330 ---CDQGFEISPSGWDCVD-VNECELMLA 1354



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 142/570 (24%), Positives = 188/570 (32%), Gaps = 110/570 (19%)

Query: 892  LSNPCGPGTCTDHVASFTCTCPPGYGGF---HCEQDLPDCSPSSCFNGGTCVDGVNSFSC 948
            L  PC P   +  + +    CP GY      HC QD+ +C          CV+   S+ C
Sbjct: 588  LCAPCPPRPASPVIENGQLECPQGYKRLNLTHC-QDINECLTLGLCKDAECVNTRGSYLC 646

Query: 949  LCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQ-TLVDWCSRQ 1007
             CRPG          DP  SR C    V   A    +  C  S     C   L    ++Q
Sbjct: 647  TCRPGLM-------LDPSRSR-C----VSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQ 694

Query: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSS 1067
             C     C + G        W G  C+   LP  EA         ++C AG         
Sbjct: 695  IC----CCSRVG------KAW-GSECEKCPLPGTEA-------FREICPAG--------H 728

Query: 1068 HYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLP-------GYNGDNCE 1120
             Y         S  + E +     P + G    G + G   E  P               
Sbjct: 729  GYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPG-PAERQPLRVVTDTWLEAGTIP 787

Query: 1121 DDVDECASQ---PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG---------P 1168
            D  D  A Q      H  + +   A    + PP     + EI E+   P          P
Sbjct: 788  DKGDSQAGQVTTSVTHAPAWVTGNA----TTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP 843

Query: 1169 PLDSGPRCLHNGT-------CVDLVGGFRCTCPPGYTGLRCEA---DINECRSGACHAAH 1218
             +D   RC    T       CV+L  G+RC C PGY     +A   D NEC    C    
Sbjct: 844  GID---RCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900

Query: 1219 TRDCLQDPGGGFRCLCHAGF------SGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLT 1272
               C+ +  G + C C+ G+      +   CQ + + CE      GGQC  + G     +
Sbjct: 901  R--CI-NRVGSYSCFCYPGYTLATSGATQECQDI-NECEQPGVCSGGQCTNTEG-----S 951

Query: 1273 FTCHCAQPFWGPR---CERVARSCRELQCPVGVPCQQTPRGPRC-ACPPGLSGPSCRSFP 1328
            + C C Q +   R   C+ +        CP G  C  +P    C AC  G  G S     
Sbjct: 952  YHCECDQGYIMVRKGHCQDINECRHPGTCPDG-RCVNSPGSYTCLACEEGYRGQS----- 1005

Query: 1329 GSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAA-APEVSEEPRC 1387
            GS     N       C HG   +   L   FRC+C QG+     E       E +    C
Sbjct: 1006 GSCVDV-NECLTPGVCAHG---KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASC 1061

Query: 1388 PRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
            P   C    G   C    N      DG  C
Sbjct: 1062 PTGLCLNTEGSFACSACENGYWVNEDGTAC 1091



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 112/484 (23%), Positives = 160/484 (33%), Gaps = 103/484 (21%)

Query: 31   LLLAGPGAAAPPCLDGS-PCANGGRCTQLPSREAACLCPPGWVGERCQLEDP-------- 81
            L+LA  GAA    ++GS  C       +  ++E  C   P   G +   E P        
Sbjct: 1351 LMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR--PRGAGGQSMSEAPTGDHAPAP 1408

Query: 82   ----CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCS-V 136
                C+SG   G   C S +   T +  C C +G      S  D C   P    A  S +
Sbjct: 1409 TRMDCYSGQ-KGHAPCSSVLGRNTTQAECCCTQG-----ASWGDACDLCPSEDSAEFSEI 1462

Query: 137  GPDGRFLCSCPPGYQ-GRSCRSDVDECRVGEP--CRHGGTCLNTPGSFRCQCPAGY---- 189
             P G+        +  G++  +D DEC +  P  C +G  CLNT   + C C  G+    
Sbjct: 1463 CPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDA 1521

Query: 190  TGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP----GFEGQNC------------ 233
            +   CE+    C    C NG      G  ++ C C P        Q C            
Sbjct: 1522 SHKKCEDHD-ECQDLACENGECVNTEG--SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPD 1578

Query: 234  -EVNVDDC-------------PGHRCLNGGTCVDGVNTYNCQC---PP---EWTGQFCTE 273
             ++++D C              GHR      C      ++ QC   PP   E   Q C  
Sbjct: 1579 HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNV 1638

Query: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI--DDCATAVCFHGATCHD 331
               E + +       G  +          + G  G      +  +D      F     H 
Sbjct: 1639 ARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHS 1698

Query: 332  RVASFYCACPMGKTGLLCHLDDACVSNPCHEDAI----------CDTNPVNGRAI----- 376
               +     P+  + L  H   +    P   + +          C+    NGR +     
Sbjct: 1699 ADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCE----NGRCVRVREG 1754

Query: 377  --CTCPPGFTGGACDQ---DVDECSIGANP---CEHLGRCVNTQGSFLCQCGRGYTG--- 425
              C C  GF   A      DV+EC     P   C H G C NT+GS+ C C  GY     
Sbjct: 1755 YTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH-GYCENTEGSYRCHCSPGYVAEAG 1813

Query: 426  -PRC 428
             P C
Sbjct: 1814 PPHC 1817



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 145/648 (22%), Positives = 213/648 (32%), Gaps = 166/648 (25%)

Query: 371 VNGRAIC--TCPPGFTGGACDQDVDEC--SIGANPCEHLGRCVNTQGSFLCQCGRGYTGP 426
           + GR +C   C PG+T        + C   +   PC++ G C   Q   LC C  G+ G 
Sbjct: 163 LTGRNVCGGQCCPGWTTA---NSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGFRGA 216

Query: 427 RCETDVNECLSGPCRNQAT---CLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGV 483
           RCE  + +    P  ++       +R         AG  GT         QS P      
Sbjct: 217 RCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAG-EGTLARAQPPAPQSPPAPQSPP 275

Query: 484 CKDRVNGFSCTCPS----GFSGSTCQLDVDECASTPCRNGA----KCVDQPDGYECRCAE 535
               ++G S T PS    G S  T +L     AS+   + A      ++Q DG +     
Sbjct: 276 A-GTLSGLSQTHPSQQHVGLS-RTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPL 333

Query: 536 GFEGTLCDRNVDD------------CSPDPCHHGRCVDGIASFSCACAPGYTGT------ 577
               +    N+ +                 C  G C +       +C  G T T      
Sbjct: 334 EHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCAN-------SCERGDTTTLYSQGG 386

Query: 578 -----RCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG 632
                +   ++  C+  PC +GG+C   + +  C CP+ +TG  C + I      P   G
Sbjct: 387 HGHDPKSGFRIYFCQI-PCLNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREPPGRG 442

Query: 633 VCRDGINRYDCVCQPGFTGPLCN---------------------VEINECASSPCGEGGS 671
             R        + Q  FT PL N                     V+I++ A    G   +
Sbjct: 443 -SRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEA 501

Query: 672 CVDGENGFRCLCPP-------------------GSLPPLCLPPSHPCAHEPCSHGICYDA 712
            V  EN      PP                      PP  LPP+ P              
Sbjct: 502 LV--ENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAP-------------R 546

Query: 713 PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL 772
           P G    C       +C+  L  +    + C     C S G  +  T           L 
Sbjct: 547 PRGLLGRCYLNTVNGQCANPLL-ELTTQEDC-----CGSVGAFWGVT-----------LC 589

Query: 773 SPCTPNPCEHGGRCESAPGQLPVCSCPQGWQG---PRCQQDVDECAGPAPCGPHGICTNL 829
           +PC P P           GQL    CPQG++      C QD++EC     C     C N 
Sbjct: 590 APCPPRPASP----VIENGQL---ECPQGYKRLNLTHC-QDINECLTLGLC-KDAECVNT 640

Query: 830 AGSFSCTCHGG-YTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCS-----------CLP 877
            GS+ CTC  G    PS  + ++  D    +  G C   +G  +C+           C  
Sbjct: 641 RGSYLCTCRPGLMLDPSRSRCVS--DKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCC 698

Query: 878 GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL 925
              G     + ++C      PGT      +F   CP G+G  +   D+
Sbjct: 699 SRVGKAWGSECEKCPL----PGT-----EAFREICPAGHGYTYASSDI 737



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 35/118 (29%), Positives = 38/118 (32%), Gaps = 21/118 (17%)

Query: 10  RRRRPMSPPPPPPPVRALPLLLLLAGP--GAAAPPCLDGSPCANGGRCTQLPSREAACLC 67
           RR  P+    P P  RA P L  L  P    AAPP            C           C
Sbjct: 122 RRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVC--------GGQC 173

Query: 68  PPGWVGERCQLE--DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS--LPD 121
            PGW           P    PC  RG C    +       C C  GFRG  C   +PD
Sbjct: 174 CPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQL-------CVCRSGFRGARCEEVIPD 224



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 34/114 (29%), Positives = 44/114 (38%), Gaps = 14/114 (12%)

Query: 136 VGPDGRFLCSCPPGYQGRSCRSDVDEC--RVGEPCRHGGTCLNTP-----GSFRC--QCP 186
           V P  +   S P G Q  + R+       R+G P R G      P     G   C  QC 
Sbjct: 115 VQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCC 174

Query: 187 AGYTGPLCENPAV-PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDD 239
            G+T     N  + P    PC+N G+C +       C C  GF G  CE  + D
Sbjct: 175 PGWTTANSTNHCIKPVCEPPCQNRGSCSRP----QLCVCRSGFRGARCEEVIPD 224



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 19/68 (27%), Positives = 28/68 (41%), Gaps = 13/68 (19%)

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGD 1117
            GGQC          CP   T +     + P    PCQ+ G+C       +C C  G+ G 
Sbjct: 170  GGQC----------CPGWTTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGA 216

Query: 1118 NCEDDVDE 1125
             CE+ + +
Sbjct: 217  RCEEVIPD 224



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 48/166 (28%), Positives = 57/166 (34%), Gaps = 38/166 (22%)

Query: 721 EPGWSGPRC-SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
           +PGW  PR  +++ AR    +Q  R                 P  Q R+   L    P P
Sbjct: 89  QPGWGSPRRPTEAEARRPSRAQQSRR--------------VQPPAQTRRSTPLGQQQPAP 134

Query: 780 CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHG 839
                R  +AP  LP    PQ              A P P  P G  T         C G
Sbjct: 135 -----RTRAAPA-LPRLGTPQR----------SGAAPPTP--PRGRLTGRNVCGGQCCPG 176

Query: 840 GYTGPSCDQDIND-CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
             T  S +  I   C+P PC N GSC        C C  GF G RC
Sbjct: 177 WTTANSTNHCIKPVCEP-PCQNRGSCS---RPQLCVCRSGFRGARC 218



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 21/64 (32%), Positives = 27/64 (42%), Gaps = 4/64 (6%)

Query: 254 GVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313
           G N    QC P WT    T    +   +P  C N G+C        CVC +G+ G  C +
Sbjct: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRP---QLCVCRSGFRGARCEE 220

Query: 314 NIDD 317
            I D
Sbjct: 221 VIPD 224



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 5/67 (7%)

Query: 124 LSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR--SDVDECRVGEPCRHGGTCLNTPGSF 181
           L +PC       V  +G+    CP GY+  +     D++EC     C+    C+NT GS+
Sbjct: 588 LCAPCPPRPASPVIENGQL--ECPQGYKRLNLTHCQDINECLTLGLCKDA-ECVNTRGSY 644

Query: 182 RCQCPAG 188
            C C  G
Sbjct: 645 LCTCRPG 651



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 4/53 (7%)

Query: 950  CRPGYTGAHC-QHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLV 1001
            C PG+T A+   H   P    PC + G CS       C C   F G +C+ ++
Sbjct: 173  CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGFRGARCEEVI 222



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 167 PCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197
           PC +GG C+   G   C CPA  TG  C  P
Sbjct: 403 PCLNGGRCI---GRDECWCPANSTGKFCHLP 430



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 14/38 (36%), Positives = 19/38 (50%), Gaps = 3/38 (7%)

Query: 245 CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQP 282
           CLNGG C+       C CP   TG+FC   + +   +P
Sbjct: 404 CLNGGRCI---GRDECWCPANSTGKFCHLPIPQPDREP 438



 Score = 31.6 bits (70), Expect = 9.5
 Identities = 12/28 (42%), Positives = 16/28 (57%), Gaps = 1/28 (3%)

Query: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCDI 1035
            PC NGGRC+     C CP   +G+ C +
Sbjct: 403  PCLNGGRCIGRDE-CWCPANSTGKFCHL 429


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
            sapiens]
          Length = 1037

 Score =  240 bits (613), Expect = 1e-62
 Identities = 205/701 (29%), Positives = 251/701 (35%), Gaps = 144/701 (20%)

Query: 699  CAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQ---PCRAGGTCSSDGMG 755
            CA E C HG C  AP   +C C PGW G  CS   A      Q   PC  G   S D   
Sbjct: 105  CAQE-CVHGRCV-APN--QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS 160

Query: 756  FHCTCPPGVQGRQCELLSPCTPN----PCEHGGRCESAP--GQLPVCSCPQGWQGPRCQQ 809
              C+CP G+Q   C  L PCTP      C+   +C  AP   Q   C CP    GP C  
Sbjct: 161  GVCSCPSGLQPPNC--LQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDV 218

Query: 810  DVDE------CAGPAPCGPHGICTNLAGSFSCT-----------CHGGYTGPSCDQDIND 852
               +      C     C   G+     GS SC            C  G+ GP+C Q+   
Sbjct: 219  SCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECR- 277

Query: 853  CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDV------DECLSN-PCGPGTCTDHV 905
                 C NGG C    G   C C PG+ G RC  +        +C     C P       
Sbjct: 278  -----CHNGGLCDRFTGQ--CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARC-FP 329

Query: 906  ASFTCTCPPGYGGFHCEQDL-PDCSPS-SCFNGGTCVDGVNSFSC-------LCRPGYTG 956
            A+  C C  G+ G  C   L PD     SC    TC D  +S SC        C PG+ G
Sbjct: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC-DREHSLSCHPMNGECSCLPGWAG 388

Query: 957  AHCQHEADPCLSRP-------CLHGGVCSAAHPGFRCTCLESFTGPQCQTL-------VD 1002
             HC          P       CLHGGVC A      C C   +TGP C +L       V+
Sbjct: 389  LHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG--LCQCAPGYTGPHCASLCPPDTYGVN 446

Query: 1003 WCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCV 1062
              +R  C+N   C      C+C  GW    C   S+PC              C A  QC 
Sbjct: 447  CSARCSCENAIACSPIDGECVCKEGWQRGNC---SVPCPPGTWGFS------CNASCQCA 497

Query: 1063 DEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDD 1122
             E              + C  +   C   P  HG  C+         C  G  G+ C   
Sbjct: 498  HE--------------AVCSPQTGACTCTPGWHGAHCQ-------LPCPKGQFGEGCASR 536

Query: 1123 VDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTC 1182
             D      C H   C  +  R  C C  G +G  C ++  +   G    +   C + GTC
Sbjct: 537  CD------CDHSDGCDPVHGR--CQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTC 588

Query: 1183 VDLVGGFRCTCPPGYTGLRCEADINECRSGA----CHAAHTRDCLQDPGGGFRCLCHAGF 1238
            +   G   C C PG+ G  C+      R G     C  A+   C   P  G  C C AG+
Sbjct: 589  LPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNG-TCYCLAGW 643

Query: 1239 SGPRCQTVLSP-------CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV-- 1289
            +GP C     P        ++  C HGG C P  G       +C C   + G  C     
Sbjct: 644  TGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG-------SCICPLGWTGHHCLEGCP 696

Query: 1290 -----ARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR 1325
                 A   +  QC  G  C   P    C CPPG SG  CR
Sbjct: 697  LGTFGANCSQPCQCGPGEKCH--PETGACVCPPGHSGAPCR 735



 Score =  227 bits (579), Expect = 9e-59
 Identities = 213/717 (29%), Positives = 267/717 (37%), Gaps = 178/717 (24%)

Query: 588  SQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQP 647
            +Q C HG +C   V    C+C  G  G       DDC+S                  C P
Sbjct: 106  AQECVHG-RC---VAPNQCQCVPGWRG-------DDCSSE-----------------CAP 137

Query: 648  GFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCS-- 705
            G  GP C+     C+   CG   SC D ++G  C CP G  PP CL P  P  + P    
Sbjct: 138  GMWGPQCD---KPCS---CGNNSSC-DPKSGV-CSCPSGLQPPNCLQPCTPGYYGPACQF 189

Query: 706  ----HGICYDAPGGFRCVCEPGWSGPRCSQSLARDA----CES-QPCRAGGTCSSDGMGF 756
                HG   D   G  C C    +GP C  S ++      C S   C+ GG   +     
Sbjct: 190  RCQCHGAPCDPQTG-ACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS- 247

Query: 757  HCTCPPGVQGRQCELLSPCT-----PN-----PCEHGGRCESAPGQLPVCSCPQGWQGPR 806
             C+CPPG  G  C L  PC      PN      C +GG C+   GQ   C C  G+ G R
Sbjct: 248  -CSCPPGWMGTICSL--PCPEGFHGPNCSQECRCHNGGLCDRFTGQ---CRCAPGYTGDR 301

Query: 807  CQQDV------DECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLN 860
            C+++        +CA    C P   C    G+  C C  G+TG  C   +  C       
Sbjct: 302  CREECPVGRFGQDCAETCDCAPDARCFPANGA--CLCEHGFTGDRCTDRL--CPDG--FY 355

Query: 861  GGSCQ-----DGVGSFSC-------SCLPGFAGPRCARDVDECLSNPCGPGTCTDH---- 904
            G SCQ     D   S SC       SCLPG+AG  C    + C  +  GPG C +H    
Sbjct: 356  GLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN---ESCPQDTHGPG-CQEHCLCL 411

Query: 905  ------VASFTCTCPPGYGGFHCEQDLP------DCSPS-SCFNGGTC--VDGVNSFSCL 949
                    S  C C PGY G HC    P      +CS   SC N   C  +DG     C+
Sbjct: 412  HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG----ECV 467

Query: 950  CRPGYTGAHCQHEADP------C-LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQT--- 999
            C+ G+   +C     P      C  S  C H  VCS       CTC   + G  CQ    
Sbjct: 468  CKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGA--CTCTPGWHGAHCQLPCP 525

Query: 1000 ---LVDWC-SRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLC 1055
                 + C SR  C +   C      C C  GW G  C    L C E    +       C
Sbjct: 526  KGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCH---LSCPEGLWGVNCSNTCTC 582

Query: 1056 QAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDP------CLAQPCQHGGTCRGYMGGYMCE 1109
            + GG C+ E+ +  CVC  G  G  C++   P      C+   C +   C    G   C 
Sbjct: 583  KNGGTCLPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG--TCY 638

Query: 1110 CLPGYNGDNCEDDV------DECASQ-PCQHGGSCIDLVARYLC-----------SCPPG 1151
            CL G+ G +C          + CA    C HGG+C       +C            CP G
Sbjct: 639  CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLG 698

Query: 1152 TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINE 1208
            T G  C      CGPG              C    G   C CPPG++G  C   I E
Sbjct: 699  TFGANCS-QPCQCGPGEK------------CHPETGA--CVCPPGHSGAPCRIGIQE 740



 Score =  214 bits (546), Expect = 6e-55
 Identities = 218/795 (27%), Positives = 275/795 (34%), Gaps = 233/795 (29%)

Query: 298  HSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS 357
            + C CV GW G+ CS                           C  G  G  C  D  C  
Sbjct: 118  NQCQCVPGWRGDDCSSE-------------------------CAPGMWGPQC--DKPC-- 148

Query: 358  NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLC 417
              C  ++ CD  P +G  +C+CP G     C Q                           
Sbjct: 149  -SCGNNSSCD--PKSG--VCSCPSGLQPPNCLQP-------------------------- 177

Query: 418  QCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDE----- 472
             C  GY GP C+    +C   PC  Q           C C A  TG  C+V   +     
Sbjct: 178  -CTPGYYGPACQFRC-QCHGAPCDPQTGA--------CFCPAERTGPSCDVSCSQGTSGF 227

Query: 473  -CQSS-PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYE 530
             C S+  C NGGV +      SC+CP G+ G+ C L                        
Sbjct: 228  FCPSTHSCQNGGVFQTPQG--SCSCPPGWMGTICSLP----------------------- 262

Query: 531  CRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECR-SQ 589
              C EGF G  C +   +C    CH+G   D      C CAPGYTG RC  +    R  Q
Sbjct: 263  --CPEGFHGPNCSQ---ECR---CHNGGLCDRFTG-QCRCAPGYTGDRCREECPVGRFGQ 313

Query: 590  PCRHGGKCLDLVDKY----LCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVC 645
             C     C      +     C C  G TG            + CT  +C DG   Y   C
Sbjct: 314  DCAETCDCAPDARCFPANGACLCEHGFTG------------DRCTDRLCPDGF--YGLSC 359

Query: 646  QPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC--LCPPGSLPPLCLPPSHPCAHEP 703
            Q   T   C+ E +  +  P     SC+ G  G  C   CP  +  P C        H  
Sbjct: 360  QAPCT---CDRE-HSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQE------HCL 409

Query: 704  CSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDA----CESQPCRAGGTCSSDGMGFHCT 759
            C HG    A  G  C C PG++GP C+     D     C ++ C      +   +   C 
Sbjct: 410  CLHGGVCQATSGL-CQCAPGYTGPHCASLCPPDTYGVNCSAR-CSCENAIACSPIDGECV 467

Query: 760  CPPGVQGRQCELLSPCTPNP----------CEHGGRCESAPGQLPVCSCPQGWQGPRCQ- 808
            C  G Q   C +  PC P            C H   C    G    C+C  GW G  CQ 
Sbjct: 468  CKEGWQRGNCSV--PCPPGTWGFSCNASCQCAHEAVCSPQTG---ACTCTPGWHGAHCQL 522

Query: 809  -----QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQD-------INDCDPN 856
                 Q  + CA    C     C  + G   C C  G+ G  C          +N  +  
Sbjct: 523  PCPKGQFGEGCASRCDCDHSDGCDPVHGR--CQCQAGWMGARCHLSCPEGLWGVNCSNTC 580

Query: 857  PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDEC-LSNPCGPGTCTDHV----ASFTCT 911
             C NGG+C    G+  C C PGF GP C R          C P  C +H     ++ TC 
Sbjct: 581  TCKNGGTCLPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCY 638

Query: 912  CPPGYGGFHCEQDLP------DCSPS-SCFNGGTC--VDGVNSFSCLCRPGYTGAHCQHE 962
            C  G+ G  C Q  P      +C+ +  C +GGTC   DG    SC+C  G+TG H    
Sbjct: 639  CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHH---- 690

Query: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQ--NGGRCVQTGA 1020
                    CL G  C     G  C+                   QPCQ   G +C     
Sbjct: 691  --------CLEG--CPLGTFGANCS-------------------QPCQCGPGEKCHPETG 721

Query: 1021 YCLCPPGWSGRLCDI 1035
             C+CPPG SG  C I
Sbjct: 722  ACVCPPGHSGAPCRI 736



 Score =  212 bits (539), Expect = 4e-54
 Identities = 216/779 (27%), Positives = 276/779 (35%), Gaps = 210/779 (26%)

Query: 122 PCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG-------EPCRHGGTC 174
           P  +  C HG RC V P+    C C PG++G  C S   EC  G       +PC  G   
Sbjct: 103 PLCAQECVHG-RC-VAPNQ---CQCVPGWRGDDCSS---ECAPGMWGPQCDKPCSCGNNS 154

Query: 175 LNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE 234
              P S  C CP+G   P C  P                          C PG+ G  C+
Sbjct: 155 SCDPKSGVCSCPSGLQPPNCLQP--------------------------CTPGYYGPACQ 188

Query: 235 VNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDE------CQLQPNACHNG 288
                C G  C           T  C CP E TG  C     +      C    ++C NG
Sbjct: 189 FRCQ-CHGAPC--------DPQTGACFCPAERTGPSCDVSCSQGTSGFFCP-STHSCQNG 238

Query: 289 GTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLL 348
           G  F T  G SC C  GW G  CS    +      FHG  C                   
Sbjct: 239 GV-FQTPQG-SCSCPPGWMGTICSLPCPEG-----FHGPNCSQECR-------------- 277

Query: 349 CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIG------ANPC 402
                      CH   +CD     G+  C C PG+TG  C +   EC +G      A  C
Sbjct: 278 -----------CHNGGLCDR--FTGQ--CRCAPGYTGDRCRE---ECPVGRFGQDCAETC 319

Query: 403 EHL--GRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG----PCRNQATCLDRIGQFTC- 455
           +     RC    G+  C C  G+TG RC   +  C  G     C+   TC DR    +C 
Sbjct: 320 DCAPDARCFPANGA--CLCEHGFTGDRCTDRL--CPDGFYGLSCQAPCTC-DREHSLSCH 374

Query: 456 ------ICMAGFTGTYCEVDIDECQSSP-------CVNGGVCKDRVNGFSCTCPSGFSGS 502
                  C+ G+ G +C     +    P       C++GGVC+       C C  G++G 
Sbjct: 375 PMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQ--ATSGLCQCAPGYTGP 432

Query: 503 TCQ-------LDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH 555
            C          V+  A   C N   C   P   EC C EG++   C             
Sbjct: 433 HCASLCPPDTYGVNCSARCSCENAIAC--SPIDGECVCKEGWQRGNCSVP---------- 480

Query: 556 HGRCVDGIASFSC--ACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTT 613
              C  G   FSC  +C   +    C  Q   C   P  HG  C          CP G  
Sbjct: 481 ---CPPGTWGFSCNASCQCAHEAV-CSPQTGACTCTPGWHGAHCQ-------LPCPKGQF 529

Query: 614 GVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE------CASS-PC 666
           G  C    D   S+ C      D ++   C CQ G+ G  C++   E      C+++  C
Sbjct: 530 GEGCASRCDCDHSDGC------DPVHGR-CQCQAGWMGARCHLSCPEGLWGVNCSNTCTC 582

Query: 667 GEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHE----PC---SHGICYDAPGGFRCV 719
             GG+C+  ENG  C+C PG   P C     P  +     PC   +H  C+ + G   C 
Sbjct: 583 KNGGTCLP-ENG-NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG--TCY 638

Query: 720 CEPGWSGPRCSQSL-----ARDACESQPCRAGGTCS-SDGM--------GFHCT--CPPG 763
           C  GW+GP CSQ         +  ++  C  GGTC   DG         G HC   CP G
Sbjct: 639 CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLG 698

Query: 764 VQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGP 822
             G  C    PC    C  G +C    G    C CP G  G  C+  + E     P  P
Sbjct: 699 TFGANCS--QPCQ---CGPGEKCHPETG---ACVCPPGHSGAPCRIGIQEPFTVMPTTP 749



 Score =  206 bits (524), Expect = 2e-52
 Identities = 191/687 (27%), Positives = 253/687 (36%), Gaps = 142/687 (20%)

Query: 495  CPSGF---SGSTCQLDVDECASTPC--RNGAKCVDQPDGYEC--RCAEGFEGTLCDR--- 544
            C  GF    G    L   EC    C   N  +CV    G +C   CA G  G  CD+   
Sbjct: 90   CCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCS 149

Query: 545  --NVDDCSPDP--CHHGRCVDGIASFSCA--CAPGYTGTRCESQVDECRSQPCRHGGKCL 598
              N   C P    C    C  G+   +C   C PGY G  C+ +  +C   PC       
Sbjct: 150  CGNNSSCDPKSGVCS---CPSGLQPPNCLQPCTPGYYGPACQFRC-QCHGAPCDP----- 200

Query: 599  DLVDKYLCRCPSGTTGVNCEVNIDDCASN---PCTFGVCRDGINRY---DCVCQPGFTGP 652
                   C CP+  TG +C+V+     S    P T      G+ +     C C PG+ G 
Sbjct: 201  ---QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGT 257

Query: 653  LCNVEINECASSP-------CGEGG---------SCVDGENGFRCL--CPPGSLPPLCLP 694
            +C++   E    P       C  GG          C  G  G RC   CP G     C  
Sbjct: 258  ICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDC-- 315

Query: 695  PSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTC----- 749
             +  C   P +   C+ A G   C+CE G++G RC+  L  D      C+A  TC     
Sbjct: 316  -AETCDCAPDAR--CFPANGA--CLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHS 370

Query: 750  -SSDGMGFHCTCPPGVQGRQCELLSP-CTPNP-------CEHGGRCESAPGQLPVCSCPQ 800
             S   M   C+C PG  G  C    P  T  P       C HGG C++  G   +C C  
Sbjct: 371  LSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG---LCQCAP 427

Query: 801  GWQGPRCQQDVD------ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
            G+ GP C            C+    C     C+ + G   C C  G+   +C      C 
Sbjct: 428  GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--ECVCKEGWQRGNCSV---PCP 482

Query: 855  PN----------PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCT-- 902
            P            C +   C    G  +C+C PG+ G  C      C     G G  +  
Sbjct: 483  PGTWGFSCNASCQCAHEAVCSPQTG--ACTCTPGWHGAHCQL---PCPKGQFGEGCASRC 537

Query: 903  --DH-----VASFTCTCPPGYGGFHCEQDLPD------CSPS-SCFNGGTCVDGVNSFSC 948
              DH          C C  G+ G  C    P+      CS + +C NGGTC+    + +C
Sbjct: 538  DCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLP--ENGNC 595

Query: 949  LCRPGYTGAHCQHEADP------CLSRPCLHGGVCSAAHP-GFRCTCLESFTGPQCQTLV 1001
            +C PG+ G  CQ    P      C+   C +   C   HP    C CL  +TGP C    
Sbjct: 596  VCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC---HPSNGTCYCLAGWTGPDCSQPC 652

Query: 1002 ---DW---CSRQ-PCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054
                W   C++   C +GG C      C+CP GW+G  C +   P        G    Q 
Sbjct: 653  PPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHC-LEGCP----LGTFGANCSQP 707

Query: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHC 1081
            CQ G        +  CVCP G +G+ C
Sbjct: 708  CQCGPGEKCHPETGACVCPPGHSGAPC 734



 Score =  197 bits (502), Expect = 8e-50
 Identities = 188/691 (27%), Positives = 240/691 (34%), Gaps = 190/691 (27%)

Query: 36  PGAAAPPCLDGSPCANGGRCTQLPSREAACLCP-------------PGWVGERCQLEDPC 82
           PG   P C     C N   C     +   C CP             PG+ G  CQ    C
Sbjct: 137 PGMWGPQCDKPCSCGNNSSCDP---KSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC 193

Query: 83  HSGPC---------------------AGRGV----------CQSSVVAGTARFSCRCPRG 111
           H  PC                       +G           CQ+  V  T + SC CP G
Sbjct: 194 HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPG 253

Query: 112 FRGPDCSLPDP--CLSSPCAHGARC-SVGPDGRFL--CSCPPGYQGRSCRSDVDECRVGE 166
           + G  CSLP P       C+   RC + G   RF   C C PGY G  CR +    R G+
Sbjct: 254 WMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQ 313

Query: 167 PCRHGGTCLNT----PGSFRCQCPAGYTGPLCENPAVP------CAPSPCRNGGTCRQSG 216
            C     C       P +  C C  G+TG  C +   P         +PC    TC +  
Sbjct: 314 DCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPC----TCDREH 369

Query: 217 DLTY-----DCACLPGFEGQNC------EVNVDDCPGH-RCLNGGTCVDGVNTYNCQCPP 264
            L+      +C+CLPG+ G +C      + +   C  H  CL+GG C     +  CQC P
Sbjct: 370 SLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC--QATSGLCQCAP 427

Query: 265 EWTGQFCTEDVDECQLQPN-----ACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCA 319
            +TG  C           N     +C N   C    G   CVC  GW   +CS       
Sbjct: 428 GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--ECVCKEGWQRGNCS------- 478

Query: 320 TAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTC 379
                               CP G  G  C+      S  C  +A+C  +P  G   CTC
Sbjct: 479 ------------------VPCPPGTWGFSCN-----ASCQCAHEAVC--SPQTG--ACTC 511

Query: 380 PPGFTGGACDQDVDECSIGAN-----PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNE 434
            PG+ G  C     +   G        C+H   C    G   CQC  G+ G RC     E
Sbjct: 512 TPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGR--CQCQAGWMGARCHLSCPE 569

Query: 435 CLSG-------PCRNQATCLDRIGQFTCICMAGFTGTYCEVDID------ECQSSPCVNG 481
            L G        C+N  TCL   G   C+C  GF G  C+           C    C N 
Sbjct: 570 GLWGVNCSNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANH 627

Query: 482 GVCKDRVNGFSCTCPSGFSGSTCQLDV------DECAST-PCRNGAKCVDQPDGYECRCA 534
             C    NG +C C +G++G  C          + CA T  C +G  C   P    C C 
Sbjct: 628 SFCHPS-NG-TCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTC--HPQDGSCICP 683

Query: 535 EGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCR-- 592
            G+ G               HH  C++G       C  G  G  C        SQPC+  
Sbjct: 684 LGWTG---------------HH--CLEG-------CPLGTFGANC--------SQPCQCG 711

Query: 593 HGGKCLDLVDKYLCRCPSGTTGVNCEVNIDD 623
            G KC    +   C CP G +G  C + I +
Sbjct: 712 PGEKCHP--ETGACVCPPGHSGAPCRIGIQE 740



 Score =  197 bits (501), Expect = 1e-49
 Identities = 194/705 (27%), Positives = 248/705 (35%), Gaps = 144/705 (20%)

Query: 37  GAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGP-CAGRGVCQ 94
           G   P C     C +G RC   P++   C C PGW G+ C  E  P   GP C     C 
Sbjct: 99  GFCVPLC--AQECVHG-RCVA-PNQ---CQCVPGWRGDDCSSECAPGMWGPQCDKPCSCG 151

Query: 95  SSVVAGTARFSCRCPRGFRGPDCSLP------DPCLSSPC-AHGARCSVGPDGRFLCSCP 147
           ++         C CP G + P+C  P       P     C  HGA C         C CP
Sbjct: 152 NNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA---CFCP 208

Query: 148 PGYQGRSCRSDVDE------CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC 201
               G SC     +      C     C++GG      GS  C CP G+ G +C  P    
Sbjct: 209 AERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS--CSCPPGWMGTICSLPCPEG 266

Query: 202 APSP-------CRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP----GHRCLNGGT 250
              P       C NGG C +    T  C C PG+ G  C    ++CP    G  C     
Sbjct: 267 FHGPNCSQECRCHNGGLCDR---FTGQCRCAPGYTGDRCR---EECPVGRFGQDCAETCD 320

Query: 251 CVDGVNTY----NCQCPPEWTGQFCTEDVDECQLQPNACHNGGTC--FNTLGGH----SC 300
           C      +     C C   +TG  CT+ +        +C    TC   ++L  H     C
Sbjct: 321 CAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGEC 380

Query: 301 VCVNGWTG----ESCSQNIDDCAT---AVCFHGATCHDRVASFYCACPMGKTG------- 346
            C+ GW G    ESC Q+          +C HG  C  +  S  C C  G TG       
Sbjct: 381 SCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHCASLC 438

Query: 347 ----------LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
                       C  ++A   +P   + +C      G     CPPG  G +C+       
Sbjct: 439 PPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQ--- 495

Query: 397 IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGP-CRNQATCLDRIG---- 451
                C H   C    G+  C C  G+ G  C+    +   G  C ++  C    G    
Sbjct: 496 -----CAHEAVCSPQTGA--CTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPV 548

Query: 452 QFTCICMAGFTGTYCEVDIDE------CQSS-PCVNGGVCKDRVNGFSCTCPSGFSGSTC 504
              C C AG+ G  C +   E      C ++  C NGG C    NG +C C  GF G +C
Sbjct: 549 HGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPE-NG-NCVCAPGFRGPSC 606

Query: 505 QLDVD------ECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558
           Q           C    C N + C   P    C C  G+ G        DCS  PC  G 
Sbjct: 607 QRSCQPGRYGKRCVPCKCANHSFC--HPSNGTCYCLAGWTG-------PDCS-QPCPPGH 656

Query: 559 CVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
             +  A  +C C  G T   C  Q   C       G  CL+        CP GT G NC 
Sbjct: 657 WGENCAQ-TCQCHHGGT---CHPQDGSCICPLGWTGHHCLE-------GCPLGTFGANC- 704

Query: 619 VNIDDCASNPCTFG---VCRDGINRYDCVCQPGFTGPLCNVEINE 660
                  S PC  G    C        CVC PG +G  C + I E
Sbjct: 705 -------SQPCQCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQE 740



 Score =  192 bits (489), Expect = 2e-48
 Identities = 180/644 (27%), Positives = 212/644 (32%), Gaps = 155/644 (24%)

Query: 878  GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL------PDCS-P 930
            GF  P CA+   EC+   C        VA   C C PG+ G  C  +       P C  P
Sbjct: 99   GFCVPLCAQ---ECVHGRC--------VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKP 147

Query: 931  SSCFNGGTC---------VDGVNSFSCL--CRPGYTGAHCQHEADPCLSRPCLHGGVCSA 979
             SC N  +C           G+   +CL  C PGY G  CQ            HG  C  
Sbjct: 148  CSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQ-------CHGAPCDP 200

Query: 980  AHPGFRCTCLESFTGPQCQTLVD------WC-SRQPCQNGGRCVQTGAYCLCPPGWSGRL 1032
                  C C    TGP C           +C S   CQNGG        C CPPGW G +
Sbjct: 201  QTGA--CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTI 258

Query: 1033 CDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV------D 1086
            C   SLPC E         E  C  GG C  +  +  C C  G TG  C +E        
Sbjct: 259  C---SLPCPEGFHGPNCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGRFGQ 313

Query: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV------DECASQPC----QHGGS 1136
             C A+ C      R +     C C  G+ GD C D +            PC    +H  S
Sbjct: 314  DC-AETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLS 372

Query: 1137 CIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPG 1196
            C  +     CSC PG  G+ C  +      GP       CLH G C    G   C C PG
Sbjct: 373  CHPMNGE--CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG--LCQCAPG 428

Query: 1197 YTGLRCEA-------DIN--------------------ECRSG----------------- 1212
            YTG  C +        +N                     C+ G                 
Sbjct: 429  YTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGF 488

Query: 1213 ----ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVL------SPCESQ-PCQHGGQC 1261
                +C  AH   C    G    C C  G+ G  CQ           C S+  C H   C
Sbjct: 489  SCNASCQCAHEAVCSPQTGA---CTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC 545

Query: 1262 RPSPG----PGGGLTFTCH--CAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCAC 1315
             P  G      G +   CH  C +  WG  C           C  G  C   P    C C
Sbjct: 546  DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTC------TCKNGGTC--LPENGNCVC 597

Query: 1316 PPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAP 1375
             PG  GPSC+      PG     C    C +   C P+       C C  GWTGP C  P
Sbjct: 598  APGFRGPSCQR--SCQPGRYGKRCVPCKCANHSFCHPSN----GTCYCLAGWTGPDCSQP 651

Query: 1376 AAAPEVSEEPRCPRAACQAKRGD--QRCDRECNSPGCGWDGGDC 1417
                   E   C +  CQ   G      D  C  P  GW G  C
Sbjct: 652  CPPGHWGE--NCAQ-TCQCHHGGTCHPQDGSCICP-LGWTGHHC 691



 Score =  165 bits (418), Expect = 4e-40
 Identities = 167/579 (28%), Positives = 199/579 (34%), Gaps = 123/579 (21%)

Query: 1013 GRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVC 1072
            GRCV     C C PGW G  C     P        G + ++ C  G     +  S  C C
Sbjct: 112  GRCVAPNQ-CQCVPGWRGDDCSSECAP-----GMWGPQCDKPCSCGNNSSCDPKSGVCSC 165

Query: 1073 PEGRTGSHCEQEVDPCLAQP-----CQ-HGGTCRGYMGGYMCECLPGYNGDNCEDDVDEC 1126
            P G    +C Q   P    P     CQ HG  C    G   C C     G +C+    + 
Sbjct: 166  PSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA--CFCPAERTGPSCDVSCSQG 223

Query: 1127 AS-------QPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
             S         CQ+GG  +    +  CSCPPG +G +C +   +   GP      RC + 
Sbjct: 224  TSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNG 281

Query: 1180 GTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQD----PGGGFRCLCH 1235
            G C    G  +C C PGYTG RC  +    R G    A T DC  D    P  G  CLC 
Sbjct: 282  GLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQ-DCAETCDCAPDARCFPANG-ACLCE 337

Query: 1236 AGFSGPRCQTVLSP-------CESQPC----QHGGQCRPSPG-----PG-GGLTFTCHCA 1278
             GF+G RC   L P       C++ PC    +H   C P  G     PG  GL     C 
Sbjct: 338  HGFTGDRCTDRLCPDGFYGLSCQA-PCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCP 396

Query: 1279 QPFWGPRCERVARSCRELQCPVGVPCQQTP---------RGPRCA--CPPGLSGPSCR-- 1325
            Q   GP C+          C  G  CQ T           GP CA  CPP   G +C   
Sbjct: 397  QDTHGPGCQ------EHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSAR 450

Query: 1326 ---------------------------SFPGSPPGASNASC-AAAPCLHGGSCRPAPLAP 1357
                                       S P  PPG    SC A+  C H   C P   A 
Sbjct: 451  CSCENAIACSPIDGECVCKEGWQRGNCSVP-CPPGTWGFSCNASCQCAHEAVCSPQTGA- 508

Query: 1358 FFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
               C C  GW G  C+ P    +   E    R  C    G       C     GW G  C
Sbjct: 509  ---CTCTPGWHGAHCQLPCPKGQFG-EGCASRCDCDHSDGCDPVHGRCQCQ-AGWMGARC 563

Query: 1418 SLSVGDP-W-----RQCEALQ---CWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN 1468
             LS  +  W       C       C     N  C P    P+C      C  G   + C 
Sbjct: 564  HLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSC---QRSCQPGRYGKRCV 620

Query: 1469 PVYEKYCADHFADGRCDQGCNTEEC--GWDGLDCASEVP 1505
            P     CA+H     C     T  C  GW G DC+   P
Sbjct: 621  PC---KCANH---SFCHPSNGTCYCLAGWTGPDCSQPCP 653



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 57/183 (31%), Positives = 69/183 (37%), Gaps = 30/183 (16%)

Query: 43  CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGV---CQSSVVA 99
           C +   C NGG C  LP     C+C PG+ G  CQ    C  G    R V   C +    
Sbjct: 576 CSNTCTCKNGGTC--LPEN-GNCVCAPGFRGPSCQRS--CQPGRYGKRCVPCKCANHSFC 630

Query: 100 GTARFSCRCPRGFRGPDCSLPDP--------CLSSPCAHGARCSVGPDGRFLC------- 144
             +  +C C  G+ GPDCS P P          +  C HG  C    DG  +C       
Sbjct: 631 HPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHP-QDGSCICPLGWTGH 689

Query: 145 ----SCPPGYQGRSCRSDVDECRVGEPCR-HGGTCLNTPGSFRCQCPAGYTGPLCENPAV 199
                CP G  G +C S   +C  GE C    G C+  PG     C  G   P    P  
Sbjct: 690 HCLEGCPLGTFGANC-SQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTT 748

Query: 200 PCA 202
           P A
Sbjct: 749 PVA 751


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  238 bits (608), Expect = 4e-62
 Identities = 128/336 (38%), Positives = 172/336 (51%), Gaps = 29/336 (8%)

Query: 378 TCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLS 437
           +C PG+TG  C Q +  C  G +  E  G C        C C  G+ G  C    NEC+ 
Sbjct: 207 SCLPGWTGEYCQQPI--CLSGCH--EQNGYCSKPAE---CLCRPGWQGRLC----NECIP 255

Query: 438 GPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC-QSSPCVNGGVCKDR-VNGFSCTC 495
                  TC      + C C  G+ G +C+ D++ C   SPC NG  C +     ++CTC
Sbjct: 256 HNGCRHGTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTC 312

Query: 496 PSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH 555
             G++G  C+L++ EC S PCRNG  C DQ DGY C C  G+ G  C+ +   C+  PC 
Sbjct: 313 RPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCF 372

Query: 556 HG---RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGT 612
           +G   R  +  A+++C C P +TG+ CE +VD C S PC +GG+CL+     +CRC  G 
Sbjct: 373 NGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGF 432

Query: 613 TGVNCEVNIDDCASNPCTF-GVCRDGINRYDCVCQPGFTGPLCNV--EINECASSPCGEG 669
           TG  CE+++ DCA NPC   G C D  N   C C  GF+G  C V   I+ CASSPC   
Sbjct: 433 TGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNR 492

Query: 670 GSCVD--GENGFRCLCPPGSLPPLC-----LPPSHP 698
            +C      + F C CP G +   C     LPPS P
Sbjct: 493 ATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528



 Score =  225 bits (574), Expect = 3e-58
 Identities = 132/376 (35%), Positives = 178/376 (47%), Gaps = 39/376 (10%)

Query: 180 SFRCQCPAGYTGPLCENPAVPCAPSPCRNGG-TCRQSGDLTYDCACLPGFEGQNCEVNVD 238
           S+R  C   Y G  C      C       G   C+  G+L+    CLPG+ G+ C+  + 
Sbjct: 170 SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLS----CLPGWTGEYCQQPI- 221

Query: 239 DCPGHRCLNGGTCVDGV--NTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLG 296
                 CL+G    +G       C C P W G+ C E +       N C +G TC     
Sbjct: 222 ------CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH-----NGCRHG-TCSTPW- 268

Query: 297 GHSCVCVNGWTGESCSQNIDDCAT-AVCFHGATCHDR-VASFYCACPMGKTGLLCHLD-D 353
              C C  GW G  C Q+++ C   + C +GATC +    S+ C C  G TG+ C L+  
Sbjct: 269 --QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS 326

Query: 354 ACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV--NT 411
            C SNPC     C          C CPPG+ G  C+     C+   +PC + G C   N 
Sbjct: 327 ECDSNPCRNGGSCKDQEDGYH--CLCPPGYYGLHCEHSTLSCA--DSPCFNGGSCRERNQ 382

Query: 412 QGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDID 471
             ++ C+C   +TG  CE  V+ C S PC N   CL+R     C C  GFTGTYCE+ + 
Sbjct: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVS 442

Query: 472 ECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL--DVDECASTPCRNGAKCVD--QPD 527
           +C  +PC +GG C D  NG  CTCP+GFSG  C++   +D CAS+PC N A C      D
Sbjct: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTD 502

Query: 528 GYECRCAEGFEGTLCD 543
            + C C  GF G+ C+
Sbjct: 503 TFVCNCPYGFVGSRCE 518



 Score =  222 bits (566), Expect = 3e-57
 Identities = 120/316 (37%), Positives = 159/316 (50%), Gaps = 25/316 (7%)

Query: 41  PPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG 100
           P CL G    NG       S+ A CLC PGW G  C    P H+G     G C +     
Sbjct: 220 PICLSGCHEQNG-----YCSKPAECLCRPGWQGRLCNECIP-HNG--CRHGTCSTP---- 267

Query: 101 TARFSCRCPRGFRGPDCSLP-DPCLS-SPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158
              + C C  G+ G  C    + C   SPC +GA CS      + C+C PGY G  C  +
Sbjct: 268 ---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324

Query: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD- 217
           + EC    PCR+GG+C +    + C CP GY G  CE+  + CA SPC NGG+CR+    
Sbjct: 325 LSECD-SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQG 383

Query: 218 LTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDE 277
             Y C C P F G NCE  VD C  + C NGG C++   +  C+C P +TG +C   V +
Sbjct: 384 ANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD 443

Query: 278 CQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCS--QNIDDCATAVCFHGATCHDRVA- 334
           C   P  C +GGTC +   G  C C  G++G  C    +ID CA++ CF+ ATC+  ++ 
Sbjct: 444 CARNP--CAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLST 501

Query: 335 -SFYCACPMGKTGLLC 349
            +F C CP G  G  C
Sbjct: 502 DTFVCNCPYGFVGSRC 517



 Score =  220 bits (561), Expect = 1e-56
 Identities = 134/390 (34%), Positives = 181/390 (46%), Gaps = 49/390 (12%)

Query: 827  TNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCA 885
            T L  S+   C   Y G +C +       N       CQ DG    + SCLPG+ G  C 
Sbjct: 165  TRLRYSYRVICSDNYYGDNCSRLCKK--RNDHFGHYVCQPDG----NLSCLPGWTGEYCQ 218

Query: 886  RDVDECLSNPCGP--GTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGV 943
            + +  CLS  C    G C+       C C PG+ G  C +    C P +    GTC    
Sbjct: 219  QPI--CLSG-CHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIPHNGCRHGTCS--- 265

Query: 944  NSFSCLCRPGYTGAHCQHEADPCLSR-PCLHGGVCS-AAHPGFRCTCLESFTGPQCQTLV 1001
              + C C  G+ G  C  + + C    PC +G  CS +    + CTC   +TG  C+  +
Sbjct: 266  TPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL 325

Query: 1002 DWCSRQPCQNGGRCV--QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGG 1059
              C   PC+NGG C   + G +CLCPPG+ G  C+  +L C ++           C  GG
Sbjct: 326  SECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP----------CFNGG 375

Query: 1060 QCVDED--SSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGD 1117
             C + +  +++ C CP   TGS+CE++VD C + PC +GG C       MC C PG+ G 
Sbjct: 376  SCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGT 435

Query: 1118 NCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINE--DDCGPGPPLDSGPR 1175
             CE  V +CA  PC HGG+C DL    +C+CP G  G  CE+    D C   P       
Sbjct: 436  YCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSP------- 488

Query: 1176 CLHNGTC-VDL-VGGFRCTCPPGYTGLRCE 1203
            C +  TC  DL    F C CP G+ G RCE
Sbjct: 489  CFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score =  208 bits (529), Expect = 6e-53
 Identities = 132/389 (33%), Positives = 181/389 (46%), Gaps = 38/389 (9%)

Query: 103 RFSCR--CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
           R+S R  C   + G +CS           H       PDG    SC PG+ G  C+  + 
Sbjct: 168 RYSYRVICSDNYYGDNCSR---LCKKRNDHFGHYVCQPDGNL--SCLPGWTGEYCQQPI- 221

Query: 161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAP-SPCRNGGTCRQSGDLT 219
            C  G  C       + P    C C  G+ G LC      C P + CR+G TC       
Sbjct: 222 -CLSG--CHEQNGYCSKPAE--CLCRPGWQGRLCNE----CIPHNGCRHG-TC----STP 267

Query: 220 YDCACLPGFEGQNCEVNVDDCPGHR-CLNGGTCVD-GVNTYNCQCPPEWTGQFCTEDVDE 277
           + C C  G+ G  C+ +++ C  H  C NG TC + G  +Y C C P +TG  C  ++ E
Sbjct: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327

Query: 278 CQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV--AS 335
           C   P  C NGG+C +   G+ C+C  G+ G  C  +   CA + CF+G +C +R   A+
Sbjct: 328 CDSNP--CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGAN 385

Query: 336 FYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDE 394
           + C CP   TG  C    D C SNPC     C     +   +C C PGFTG  C+  V +
Sbjct: 386 YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPS--RMCRCRPGFTGTYCELHVSD 443

Query: 395 CSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE--TDVNECLSGPCRNQATCLDRIGQ 452
           C+   NPC H G C + +   +C C  G++G RCE  T ++ C S PC N+ATC   +  
Sbjct: 444 CA--RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLST 501

Query: 453 --FTCICMAGFTGTYCEVDIDECQSSPCV 479
             F C C  GF G+ CE  +    S P V
Sbjct: 502 DTFVCNCPYGFVGSRCEFPVGLPPSFPWV 530



 Score =  207 bits (528), Expect = 7e-53
 Identities = 126/379 (33%), Positives = 170/379 (44%), Gaps = 51/379 (13%)

Query: 565 SFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCR------CPSGTTGVNCE 618
           S+   C+  Y G  C        S+ C+   K  D    Y+C+      C  G TG  C+
Sbjct: 170 SYRVICSDNYYGDNC--------SRLCK---KRNDHFGHYVCQPDGNLSCLPGWTGEYCQ 218

Query: 619 VNIDDCASNPCTFGVCRDGINRY-----DCVCQPGFTGPLCNVEINECASSPCGEGGSCV 673
                    P     C +  N Y     +C+C+PG+ G LCN    EC        G+C 
Sbjct: 219 --------QPICLSGCHEQ-NGYCSKPAECLCRPGWQGRLCN----ECIPHNGCRHGTC- 264

Query: 674 DGENGFRCLCPPGSLPPLCLPPSHPCAHE-PCSHGICYDAPG--GFRCVCEPGWSGPRCS 730
                ++C C  G     C    + C H  PC +G      G   + C C PG++G  C 
Sbjct: 265 --STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE 322

Query: 731 QSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLS-PCTPNPCEHGGRC-ES 788
             L+   C+S PCR GG+C     G+HC CPPG  G  CE  +  C  +PC +GG C E 
Sbjct: 323 LELSE--CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRER 380

Query: 789 APGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ 848
             G    C CP  + G  C++ VD C    PC   G C N   S  C C  G+TG  C+ 
Sbjct: 381 NQGANYACECPPNFTGSNCEKKVDRCTSN-PCANGGQCLNRGPSRMCRCRPGFTGTYCEL 439

Query: 849 DINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC--ARDVDECLSNPC-GPGTCTDHV 905
            ++DC  NPC +GG+C D      C+C  GF+G RC     +D C S+PC    TC   +
Sbjct: 440 HVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDL 499

Query: 906 A--SFTCTCPPGYGGFHCE 922
           +  +F C CP G+ G  CE
Sbjct: 500 STDTFVCNCPYGFVGSRCE 518



 Score =  206 bits (523), Expect = 3e-52
 Identities = 121/338 (35%), Positives = 163/338 (48%), Gaps = 31/338 (9%)

Query: 523 VDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH--HGRCVDGIASFSCACAPGYTGTRCE 580
           V QPDG    C  G+ G  C + +       CH  +G C        C C PG+ G  C 
Sbjct: 199 VCQPDG-NLSCLPGWTGEYCQQPI---CLSGCHEQNGYCSKPA---ECLCRPGWQGRLCN 251

Query: 581 SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN-PCTFGVC--RDG 637
             +       CRHG         + C C  G  G+ C+ +++ C  + PC  G      G
Sbjct: 252 ECIPH---NGCRHG----TCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304

Query: 638 INRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSH 697
              Y C C+PG+TG  C +E++EC S+PC  GGSC D E+G+ CLCPPG     C   + 
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364

Query: 698 PCAHEPC-SHGICYDAPGG--FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM 754
            CA  PC + G C +   G  + C C P ++G  C + +  D C S PC  GG C + G 
Sbjct: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV--DRCTSNPCANGGQCLNRGP 422

Query: 755 GFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ--QDV 811
              C C PG  G  CEL +S C  NPC HGG C      L +C+CP G+ G RC+    +
Sbjct: 423 SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGL-MCTCPAGFSGRRCEVRTSI 481

Query: 812 DECAGPAPCGPHGIC-TNLA-GSFSCTCHGGYTGPSCD 847
           D CA  +PC     C T+L+  +F C C  G+ G  C+
Sbjct: 482 DACAS-SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score =  195 bits (495), Expect = 5e-49
 Identities = 133/397 (33%), Positives = 169/397 (42%), Gaps = 50/397 (12%)

Query: 945  SFSCLCRPGYTGAHCQHEADPCLSRPCLHGG-VCSAAHPGFRCTCLESFTGPQCQTLVDW 1003
            S+  +C   Y G +C      C  R    G  VC    P    +CL  +TG  CQ  +  
Sbjct: 170  SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQ---PDGNLSCLPGWTGEYCQQPI-- 221

Query: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
            C     +  G C +  A CLC PGW GRLC+       E     G R        G C  
Sbjct: 222  CLSGCHEQNGYCSKP-AECLCRPGWQGRLCN-------ECIPHNGCR-------HGTC-- 264

Query: 1064 EDSSHYCVCPEGRTGSHCEQEVDPCLAQ-PCQHGGTCRGY-MGGYMCECLPGYNGDNCED 1121
              +   C C EG  G  C+Q+++ C    PC++G TC       Y C C PGY G +CE 
Sbjct: 265  -STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323

Query: 1122 DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGT 1181
            ++ EC S PC++GGSC D    Y C CPPG  G+ CE +   C   P       C + G+
Sbjct: 324  ELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP-------CFNGGS 376

Query: 1182 CVDLVGG--FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS 1239
            C +   G  + C CPP +TG  CE  ++ C S  C  A+   CL + G    C C  GF+
Sbjct: 377  CRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC--ANGGQCL-NRGPSRMCRCRPGFT 433

Query: 1240 GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE--RVARSCRELQ 1297
            G  C+  +S C   PC HGG C        GL   C C   F G RCE      +C    
Sbjct: 434  GTYCELHVSDCARNPCAHGGTCHDLEN---GLM--CTCPAGFSGRRCEVRTSIDACASSP 488

Query: 1298 CPVGVPCQQTPRGPR--CACPPGLSGPSCRSFPGSPP 1332
            C     C          C CP G  G  C    G PP
Sbjct: 489  CFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPP 525



 Score =  191 bits (485), Expect = 7e-48
 Identities = 121/400 (30%), Positives = 165/400 (41%), Gaps = 50/400 (12%)

Query: 984  FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREA 1043
            +R  C +++ G  C  L   C ++    G    Q      C PGW+G  C          
Sbjct: 171  YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLSCLPGWTGEYC---------- 217

Query: 1044 AAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQP-CQHGGTCRGY 1102
              Q  + L    +  G C        C+C  G  G  C +    C+    C+HG TC   
Sbjct: 218  --QQPICLSGCHEQNGYC---SKPAECLCRPGWQGRLCNE----CIPHNGCRHG-TCST- 266

Query: 1103 MGGYMCECLPGYNGDNCEDDVDECASQ-PCQHGGSCIDLVAR-YLCSCPPGTLGVLCEIN 1160
               + C C  G+ G  C+ D++ C    PC++G +C +   R Y C+C PG  GV CE+ 
Sbjct: 267  --PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324

Query: 1161 EDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGAC-HAAHT 1219
              +C      DS P C + G+C D   G+ C CPPGY GL CE     C    C +    
Sbjct: 325  LSEC------DSNP-CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSC 377

Query: 1220 RDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQ 1279
            R+  ++ G  + C C   F+G  C+  +  C S PC +GGQC        G +  C C  
Sbjct: 378  RE--RNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL-----NRGPSRMCRCRP 430

Query: 1280 PFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASC 1339
             F G  CE     C    C  G  C     G  C CP G SG  C          S  +C
Sbjct: 431  GFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE------VRTSIDAC 484

Query: 1340 AAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAP 1379
            A++PC +  +C        F C C  G+ G RCE P   P
Sbjct: 485  ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524



 Score =  166 bits (421), Expect = 2e-40
 Identities = 107/354 (30%), Positives = 147/354 (41%), Gaps = 38/354 (10%)

Query: 1072 CPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
            C  G TG +C+Q +  CL+   +  G C        C C PG+ G  C + +       C
Sbjct: 208  CLPGWTGEYCQQPI--CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNECIPH---NGC 259

Query: 1132 QHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRC 1191
            +HG +C      + C+C  G  G+ C+ + + C    P  +G  C ++G        + C
Sbjct: 260  RHG-TCS---TPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ-----RSYTC 310

Query: 1192 TCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCE 1251
            TC PGYTG+ CE +++EC S  C    +    +D   G+ CLC  G+ G  C+     C 
Sbjct: 311  TCRPGYTGVDCELELSECDSNPCRNGGS---CKDQEDGYHCLCPPGYYGLHCEHSTLSCA 367

Query: 1252 SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGP 1311
              PC +GG CR       G  + C C   F G  CE+    C    C  G  C       
Sbjct: 368  DSPCFNGGSCRER---NQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSR 424

Query: 1312 RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371
             C C PG +G  C            + CA  PC HGG+C    L     C C  G++G R
Sbjct: 425  MCRCRPGFTGTYCELHV--------SDCARNPCAHGGTCHD--LENGLMCTCPAGFSGRR 474

Query: 1372 CEAPAAAPEVSEEPRCPRAACQAKRGDQRCDR-ECNSPGCGWDGGDCSLSVGDP 1424
            CE   +    +  P   RA C     D   D   CN P  G+ G  C   VG P
Sbjct: 475  CEVRTSIDACASSPCFNRATCYT---DLSTDTFVCNCP-YGFVGSRCEFPVGLP 524



 Score =  113 bits (283), Expect = 2e-24
 Identities = 65/162 (40%), Positives = 82/162 (50%), Gaps = 14/162 (8%)

Query: 43  CLDGSPCANGGRCTQL-PSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAG 100
           C D SPC NGG C +       AC CPP + G  C+ + D C S PCA  G C +    G
Sbjct: 366 CAD-SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR---G 421

Query: 101 TARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSC--RS 157
            +R  CRC  GF G  C L    C  +PCAHG  C    +G  +C+CP G+ GR C  R+
Sbjct: 422 PSRM-CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENG-LMCTCPAGFSGRRCEVRT 479

Query: 158 DVDECRVGEPCRHGGTCLN--TPGSFRCQCPAGYTGPLCENP 197
            +D C    PC +  TC    +  +F C CP G+ G  CE P
Sbjct: 480 SIDAC-ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  227 bits (578), Expect = 1e-58
 Identities = 237/870 (27%), Positives = 341/870 (39%), Gaps = 146/870 (16%)

Query: 469  DIDECQSSPCVNG-GVCKDRVNGFSCTCPSGFSGSTCQ---LDVDECASTP--CRNGAKC 522
            +I+EC  +P + G G C +    ++C C  G+  S  Q   +D+DEC      C  G +C
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQG-RC 932

Query: 523  VDQPDGYECRCAEGF----EGTLCDRNVDDC-SPDPCHHGRCVDGIASFSCA-CAPGYTG 576
             +    + C C  GF    EGT C  +VD+C  PD C  G CV+ + +F C  C  GY  
Sbjct: 933  ENTEGSFLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 991

Query: 577  T---RCESQVDECRSQPCRHGGKCLDLVDKYLC-RCPSGTTGVNCE-VNIDDCAS-NPCT 630
            T   RCE  +DEC +       +C++    Y C  C  G  G N + +++D+C   N C 
Sbjct: 992  TQRGRCED-IDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCA 1050

Query: 631  FGVCRDGINRYDCVCQPGFTGPLCNV---EINECASSPCGEGGSCVDGENGFRCLCPPG- 686
             G C +    Y C C  G+T    +    +I+EC        G C + E  FRC C  G 
Sbjct: 1051 NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGY 1110

Query: 687  --SLPPLCLPPSHPCAHEP-CSHGICYDAPGGFRCVCEPGWS----GPRCSQSLARDACE 739
              S           C H   C+HG C +  G F+CVC+ G+     G  C      +  E
Sbjct: 1111 QLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED--INECLE 1168

Query: 740  SQPCRAGGTCSSDGMGFHCTCPPGVQ---GRQCELLSPCT-PNPCEHGGRCESAPGQLPV 795
             +     G C +    + CTCP G Q    + C+ ++ C  P  C   G C +  G    
Sbjct: 1169 DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFH- 1227

Query: 796  CSCPQGWQ----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ--- 848
            C C QG+     G  C+ D+DEC     C  HG C N AGSF C C+ G+  P   Q   
Sbjct: 1228 CVCQQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV 1286

Query: 849  DINDCDPNPCLNGGS-CQDGVGSFSCSC---------LPGFAGPRCARDVD--------- 889
            D+N+C+    + G + C++  GSF C C         + G    R + D+D         
Sbjct: 1287 DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346

Query: 890  --ECLSNPCGPGTCTD----HVASFTCTCPPGYG-GFHCEQDLPDCSPSSCFNGGTCVDG 942
              EC  N      C +    +V    C C  G G G +CE  +  C           V G
Sbjct: 1347 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCE--IFPCP----------VLG 1394

Query: 943  VNSFSCLCRPG-----------YTGAHCQHEADPCL--SRPCLHGGVCSAAHPGFRCTCL 989
               F+ +C  G             G     +AD CL   +     G C    PG+ C C 
Sbjct: 1395 TAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCK 1454

Query: 990  E-SFTGP---QCQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREA 1043
            + ++  P   QC  + D C        G+CV T G+Y C C         + R +   E+
Sbjct: 1455 QGTYYDPVKLQCFDM-DECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1513

Query: 1044 AAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYM 1103
              QI    E+       C +  S  Y VC     G         CL           G  
Sbjct: 1514 NEQI----EETDVYQDLCWEHLSDEY-VCSRPLVGKQTTYTECCCL----------YGEA 1558

Query: 1104 GGYMCECLPGYNGDNCED--DVDECASQPCQHGGSCIDLVARYLCSCPP-----GTLGVL 1156
             G  C   P  + D+     ++     +      + +D   +Y     P       L   
Sbjct: 1559 WGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSF 1618

Query: 1157 CEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY---TGLRCEADINEC---- 1209
             E+  ++CG    + +G     NG CV +  G+ C C  GY   T      D+NEC    
Sbjct: 1619 EELQAEECG----ILNG---CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELN 1671

Query: 1210 -RSGACHAAHTRDCLQDPGGGFRCLCHAGF 1238
             R   C  A    C+ +  G ++CLC  G+
Sbjct: 1672 NRMSLCKNA---KCI-NTDGSYKCLCLPGY 1697



 Score =  207 bits (527), Expect = 1e-52
 Identities = 278/1059 (26%), Positives = 387/1059 (36%), Gaps = 249/1059 (23%)

Query: 16   SPPPPPPPVRALPLLLLLA----GPGAAAP-----------PCLDGSPCA-NGGRCTQLP 59
            S  PPP P +  P+  L      GPG A P           P LD        G+    P
Sbjct: 768  STHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSP 827

Query: 60   SREAACLCP--PGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
                  L P  PG V E+     P    P A      S V+A T              +C
Sbjct: 828  GISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSA-SQVIAPTQVTEIN--------EC 878

Query: 118  SL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGG 172
            ++ PD C +  C       +    R+ C C  GY    Q R C  D+DEC   +     G
Sbjct: 879  TVNPDICGAGHC-------INLPVRYTCICYEGYRFSEQQRKC-VDIDECTQVQHLCSQG 930

Query: 173  TCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN 232
             C NT GSF C CPAG+                                   +   EG N
Sbjct: 931  RCENTEGSFLCICPAGF-----------------------------------MASEEGTN 955

Query: 233  CEVNVDDCPGHRCLNGGTCVDGVNTYNCQ-CPPEW--TGQFCTEDVDECQLQPNACHNGG 289
            C ++VD+C        G CV+ V  + C+ C   +  T +   ED+DEC L P+ C +  
Sbjct: 956  C-IDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPD-E 1012

Query: 290  TCFNTLGGHSCV-CV---NGWTGESCSQNIDDCATA-VCFHGATCHDRVASFYCACPMGK 344
             C N+ G + CV C     GW G+    ++D+C    VC +G  C +   S+ C+C  G 
Sbjct: 1013 QCVNSPGSYQCVPCTEGFRGWNGQCL--DVDECLEPNVCANG-DCSNLEGSYMCSCHKGY 1069

Query: 345  TGLLCH-----LDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD---QDVDECS 396
            T    H     +D+    N C      +T    G   CTC  G+   A     +D+DEC 
Sbjct: 1070 TRTPDHKHCRDIDECQQGNLCVNGQCKNT---EGSFRCTCGQGYQLSAAKDQCEDIDECQ 1126

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECL--SGPCRNQATCLDRI 450
               + C H G+C NT+GSF C C +GY     G  CE D+NECL     C+ +  C++  
Sbjct: 1127 -HRHLCAH-GQCRNTEGSFQCVCDQGYRASGLGDHCE-DINECLEDKSVCQ-RGDCINTA 1182

Query: 451  GQFTCICMAGF---TGTYCEVDIDECQ-SSPCVNGGVCKDRVNGFSCTCPSGFS----GS 502
            G + C C  GF       C+ DI+EC+    C   G C +    F C C  GFS    G 
Sbjct: 1183 GSYDCTCPDGFQLDDNKTCQ-DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGR 1241

Query: 503  TCQLDVDECA-STPCRNGAKCVDQPDGYECRCAEGF----EGTLC-DRNVDDCSPDPCHH 556
            TC+ D+DEC  +T C +   C +    + C C +GF    +G  C D N  +     C  
Sbjct: 1242 TCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE 1300

Query: 557  GRCVDGIASFSCACA---------PGYTGTRCESQVDECRSQPCRHGGKC------LDLV 601
              C +   SF C CA          G   +R  + +D    QP     +C        L 
Sbjct: 1301 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1360

Query: 602  DKYL--------CRCPSGT-TGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGP 652
            D  L        C C SG   G NCE+        PC       G   +  +C  G    
Sbjct: 1361 DNVLAPNVTKQECCCTSGAGWGDNCEI-------FPCPV----LGTAEFTEMCPKG---- 1405

Query: 653  LCNVEINECASSPCGEGGSCVDGEN---GFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
                        P GE  S   GEN      CL                   E C +G C
Sbjct: 1406 --------KGFVPAGESSSEAGGENYKDADECLL---------------FGQEICKNGFC 1442

Query: 710  YDAPGGFRCVCEPG-WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC--PPGVQG 766
             +   G+ C C+ G +  P   Q    D C+       G C +    ++C C  P  +  
Sbjct: 1443 LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDA 1502

Query: 767  RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826
             +   +      P E   + E       +C     W+      D   C+ P       + 
Sbjct: 1503 SEKRCI-----RPAESNEQIEETDVYQDLC-----WEH---LSDEYVCSRPL------VG 1543

Query: 827  TNLAGSFSCTCHGGYTGPSCD----QDIND----CD-PNPCLNGGSCQDGVGSFSCSCLP 877
                 +  C  +G   G  C     +D +D    C+ P         +D +  FS    P
Sbjct: 1544 KQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTP 1603

Query: 878  GFAGPRCARD----------VDEC-LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ--- 923
              A P   +D           +EC + N C  G C      +TC C   + G+H +    
Sbjct: 1604 E-ADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDC---FDGYHLDTAKM 1659

Query: 924  ---DLPDCSP-----SSCFNGGTCVDGVNSFSCLCRPGY 954
               D+ +C       S C N   C++   S+ CLC PGY
Sbjct: 1660 TCVDVNECDELNNRMSLCKN-AKCINTDGSYKCLCLPGY 1697



 Score =  183 bits (464), Expect = 2e-45
 Identities = 187/653 (28%), Positives = 259/653 (39%), Gaps = 116/653 (17%)

Query: 581  SQVDECRSQPCRHG-GKCLDLVDKYLCRCPSGTTGVNCE---VNIDDCAS--NPCTFGVC 634
            ++++EC   P   G G C++L  +Y C C  G      +   V+ID+C    + C+ G C
Sbjct: 873  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932

Query: 635  RDGINRYDCVCQPGFT----GPLCNVEINECASSP-CGEGGSCVDGENGFRC-LCPPGSL 688
             +    + C+C  GF     G  C ++++EC     CGEG  CV+    FRC  C  G  
Sbjct: 933  ENTEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYR 990

Query: 689  PPL---------CLPPSHPCAHEPCSHGICYDAPGGFRCV-CEPGWSGPRCSQSLARDAC 738
                        CL PS       C    C ++PG ++CV C  G+ G    Q L  D C
Sbjct: 991  MTQRGRCEDIDECLNPS------TCPDEQCVNSPGSYQCVPCTEGFRGWN-GQCLDVDEC 1043

Query: 739  ESQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPCTPNPCEHGGRCESAPGQLP 794
                  A G CS+    + C+C  G       + C  +  C        G+C++  G   
Sbjct: 1044 LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFR 1103

Query: 795  VCSCPQGWQGPRCQ---QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT----GPSCD 847
             C+C QG+Q    +   +D+DEC     C  HG C N  GSF C C  GY     G  C+
Sbjct: 1104 -CTCGQGYQLSAAKDQCEDIDECQHRHLCA-HGQCRNTEGSFQCVCDQGYRASGLGDHCE 1161

Query: 848  QDINDC--DPNPCLNGGSCQDGVGSFSCSCLPGFA--GPRCARDVDECLSNP--CGP-GT 900
             DIN+C  D + C  G  C +  GS+ C+C  GF     +  +D++EC  +P  CGP G 
Sbjct: 1162 -DINECLEDKSVCQRG-DCINTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGE 1218

Query: 901  CTDHVASFTCTCPPGYG----GFHCEQDLPDCSPSS-CFNGGTCVDGVNSFSCLCRPGYT 955
            C +   SF C C  G+     G  CE D+ +C  ++ C + G C +   SF CLC   Y 
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLC---YQ 1274

Query: 956  GAHCQHEADPCLS-RPC-LHGGVCSAA-----HPGFRCTCLES------FTGPQCQ---- 998
            G     +   C+    C L  GVC  A        F C C +        TG QC+    
Sbjct: 1275 GFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTG-QCRSRTS 1333

Query: 999  TLVDWCSRQPCQNGGRCVQ----------------TGAYCLCPPG--WSGRLCDIRSLPC 1040
            T +D    QP +    C                  T   C C  G  W G  C+I   P 
Sbjct: 1334 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGW-GDNCEIFPCPV 1392

Query: 1041 REAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCL--AQPCQHGGT 1098
               A        ++C  G   V    S          G    ++ D CL   Q     G 
Sbjct: 1393 LGTA-----EFTEMCPKGKGFVPAGES------SSEAGGENYKDADECLLFGQEICKNGF 1441

Query: 1099 CRGYMGGYMCECLPGYNGDNCE---DDVDECASQPCQHGGSCIDLVARYLCSC 1148
            C     GY C C  G   D  +    D+DEC        G C++    Y C C
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFC 1494



 Score =  169 bits (429), Expect = 2e-41
 Identities = 204/808 (25%), Positives = 299/808 (37%), Gaps = 167/808 (20%)

Query: 549  CSPDPCHHGRCVDGIASFSCACAPGY---TGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
            C   P +HG       +    C PGY     T C+  ++EC+ Q     G+CL+ +  Y 
Sbjct: 597  CPKKPSYHGY------NQMMECLPGYKRVNNTFCQD-INECQLQGVCPNGECLNTMGSYR 649

Query: 606  CRCPSGTTGVNCEVNIDDCASNPCTF----GVCRDGINRYDCVCQP---GFTGPLCNVEI 658
            C C     G   +     C  +P       G C   ++       P     T  LC   +
Sbjct: 650  CTCK---IGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV 706

Query: 659  NECASSPCGEGGSC-VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFR 717
             +     C +   C + G   F+ +CP G    +         H     G  +  P   +
Sbjct: 707  GKAWGPHCEK---CPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQ 763

Query: 718  CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQ----GRQCELLS 773
             V +     P  ++    +A         G    +      T PP  +     ++   L 
Sbjct: 764  PVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEV----ATAPPEKEIPSLDQEKTKLE 819

Query: 774  PCTP-----------NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ-------QDVDECA 815
            P  P           +P   G   E     +PV   P+       Q        +++EC 
Sbjct: 820  PGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECT 879

Query: 816  -GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ---DINDCDPNPCL-NGGSCQDGVGS 870
              P  CG  G C NL   ++C C+ GY      +   DI++C     L + G C++  GS
Sbjct: 880  VNPDICGA-GHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGS 938

Query: 871  FSCSCLPGFA----GPRCARDVDECLS-NPCGPGTCTDHVASFTCT-CPPGYGGFH---C 921
            F C C  GF     G  C  DVDECL  + CG G C + V +F C  C  GY       C
Sbjct: 939  FLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 997

Query: 922  EQDLPDC-SPSSCFNGGTCVDGVNSFSCL-CRPGYTGAHCQH-EADPCLSRPCLHGGVCS 978
            E D+ +C +PS+C +   CV+   S+ C+ C  G+ G + Q  + D CL       G CS
Sbjct: 998  E-DIDECLNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCS 1055

Query: 979  AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL 1038
                 + C+C + +T             + C++   C Q            G LC     
Sbjct: 1056 NLEGSYMCSCHKGYTRTP--------DHKHCRDIDECQQ------------GNLC----- 1090

Query: 1039 PCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE---QEVDPCLAQPCQH 1095
                                GQC + + S  C C +G   S  +   +++D C  +    
Sbjct: 1091 ------------------VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 1132

Query: 1096 GGTCRGYMGGYMCECLPGYN----GDNCEDDVDECASQP--CQHGGSCIDLVARYLCSCP 1149
             G CR   G + C C  GY     GD+CED ++EC      CQ G  CI+    Y C+CP
Sbjct: 1133 HGQCRNTEGSFQCVCDQGYRASGLGDHCED-INECLEDKSVCQRG-DCINTAGSYDCTCP 1190

Query: 1150 PGTL---GVLCE-INEDD----CGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT--- 1198
             G        C+ INE +    CGP             G C++  G F C C  G++   
Sbjct: 1191 DGFQLDDNKTCQDINECEHPGLCGP------------QGECLNTEGSFHCVCQQGFSISA 1238

Query: 1199 -GLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257
             G  CE DI+EC +     +H      +  G FRCLC+ GF  P+        + Q C  
Sbjct: 1239 DGRTCE-DIDECVNNTVCDSH--GFCDNTAGSFRCLCYQGFQAPQ--------DGQGCVD 1287

Query: 1258 GGQCRPSPGPGGGL-------TFTCHCA 1278
              +C    G  G         +F C CA
Sbjct: 1288 VNECELLSGVCGEAFCENVEGSFLCVCA 1315



 Score =  156 bits (395), Expect = 2e-37
 Identities = 197/739 (26%), Positives = 290/739 (39%), Gaps = 134/739 (18%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVG--ERCQLEDPCHSGPCAGRGVCQSSVVAG 100
            CL+ S C +  +C   P       C  G+ G   +C   D C        G C +     
Sbjct: 1003 CLNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL---- 1057

Query: 101  TARFSCRCPRGF-RGPD---CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
               + C C +G+ R PD   C   D C         +C    +G F C+C  GYQ  + +
Sbjct: 1058 EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCK-NTEGSFRCTCGQGYQLSAAK 1116

Query: 157  S---DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT----GPLCENPAVPCAP--SPCR 207
                D+DEC+    C HG  C NT GSF+C C  GY     G  CE+    C    S C+
Sbjct: 1117 DQCEDIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRASGLGDHCED-INECLEDKSVCQ 1174

Query: 208  NGGTCRQSGDLTYDCACLPGFE---GQNCEVNVDDC--PGHRCLNGGTCVDGVNTYNCQC 262
             G     +G  +YDC C  GF+    + C+ ++++C  PG  C   G C++   +++C C
Sbjct: 1175 RGDCINTAG--SYDCTCPDGFQLDDNKTCQ-DINECEHPG-LCGPQGECLNTEGSFHCVC 1230

Query: 263  PPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWT----GESCSQN 314
               ++    G+ C ED+DEC +    C + G C NT G   C+C  G+     G+ C  +
Sbjct: 1231 QQGFSISADGRTC-EDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-D 1287

Query: 315  IDDCA--TAVCFHGATCHDRVASFYCAC--------PM-GKTGLLCHLD-DACVSNPCHE 362
            +++C   + VC   A C +   SF C C        PM G+       D D  V  P  E
Sbjct: 1288 VNECELLSGVCGE-AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346

Query: 363  DAICDTNPVNGRAIC--TCPPGFTGGACDQDVDECSIGAN--------PCEHLGRCVNTQ 412
               C  N +N  ++C     P  T   C      C+ GA         PC  LG    T+
Sbjct: 1347 KKECYYN-LNDASLCDNVLAPNVTKQECC-----CTSGAGWGDNCEIFPCPVLGTAEFTE 1400

Query: 413  GSFLCQCGRGYT---------GPRCETDVNECL---SGPCRNQATCLDRIGQFTCICMAG 460
               +C  G+G+          G     D +ECL      C+N   CL+    + C C  G
Sbjct: 1401 ---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKN-GFCLNTRPGYECYCKQG 1456

Query: 461  FTGTYCE------VDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
               TY +       D+DECQ       G C +    ++C C          LD  E    
Sbjct: 1457 ---TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMV-----LDASEKRCI 1508

Query: 515  PCRNGAKCVDQPDGYECRCAEGFEGT-LCDRNV---DDCSPDPCHHGRCVDGIA-SFSCA 569
                  + +++ D Y+  C E      +C R +        + C    C+ G A    CA
Sbjct: 1509 RPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECC----CLYGEAWGMQCA 1564

Query: 570  CAP----GYTGTRCESQVDECRSQPCRHGGKCL-DLVDKYLCRCPS---GTTGVNC--EV 619
              P          C   V   R QP  +G   L D  ++Y             +N   E+
Sbjct: 1565 LCPLKDSDDYAQLCNIPVTG-RRQP--YGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1621

Query: 620  NIDDCAS-NPCTFGVCRDGINRYDCVCQPGF---TGPLCNVEINECAS-----SPCGEGG 670
              ++C   N C  G C      Y C C  G+   T  +  V++NEC       S C +  
Sbjct: 1622 QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNA 1680

Query: 671  SCVDGENGFRCLCPPGSLP 689
             C++ +  ++CLC PG +P
Sbjct: 1681 KCINTDGSYKCLCLPGYVP 1699



 Score =  128 bits (322), Expect = 6e-29
 Identities = 182/755 (24%), Positives = 244/755 (32%), Gaps = 164/755 (21%)

Query: 645  CQPGF---TGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAH 701
            C PG+       C  +INEC        G C++    +RC C  G  P    P    C  
Sbjct: 612  CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGFGPD---PTFSSCVP 667

Query: 702  EPC----SHGICYDAPGGFR--------------CVCEPGWS-GPRCSQSLARDACESQP 742
            +P       G CY      R              C C  G + GP C +      C    
Sbjct: 668  DPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEK------CPLPG 721

Query: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEH----GGRCESAPGQLPVCSC 798
              A       GMG+  +   GV  R+          P  H    G          PV   
Sbjct: 722  TAAFKEICPGGMGYTVS---GVHRRR----------PIHHHVGKGPVFVKPKNTQPVAKS 768

Query: 799  PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN-P 857
                  P  ++ V+        GP      +A     T       PS DQ+    +P  P
Sbjct: 769  THPPPLPAKEEPVEALTFSREHGP-----GVAEPEVATAPPEKEIPSLDQEKTKLEPGQP 823

Query: 858  CLNGGSCQ---------------------DGVGSFSCSCLPGFAGPRCARDVDECLSNP- 895
             L+ G                        +     S S       P    +++EC  NP 
Sbjct: 824  QLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPD 883

Query: 896  -CGPGTCTDHVASFTCTCPPGYGGFHCEQ---DLPDCSP-SSCFNGGTCVDGVNSFSCLC 950
             CG G C +    +TC C  GY     ++   D+ +C+      + G C +   SF C+C
Sbjct: 884  ICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCIC 943

Query: 951  RPGYTGAHCQHEADPCLS-RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPC 1009
              G+  +    E   C+    CL   VC   H      C+ +    +C+          C
Sbjct: 944  PAGFMASE---EGTNCIDVDECLRPDVCGEGH------CVNTVGAFRCEY---------C 985

Query: 1010 QNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY 1069
             +G R  Q G                    C +    I   L        QCV+   S+ 
Sbjct: 986  DSGYRMTQRGR-------------------CED----IDECLNPSTCPDEQCVNSPGSYQ 1022

Query: 1070 CV-CPEGRTGSHCE-QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDV 1123
            CV C EG  G + +  +VD CL       G C    G YMC C  GY    +  +C  D+
Sbjct: 1023 CVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR-DI 1081

Query: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183
            DEC        G C +    + C+C     G      +D C           C H G C 
Sbjct: 1082 DECQQGNLCVNGQCKNTEGSFRCTCGQ---GYQLSAAKDQCEDIDECQHRHLCAH-GQCR 1137

Query: 1184 DLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGF- 1238
            +  G F+C C  GY     G  CE DINEC           DC+ +  G + C C  GF 
Sbjct: 1138 NTEGSFQCVCDQGYRASGLGDHCE-DINECLEDK-SVCQRGDCI-NTAGSYDCTCPDGFQ 1194

Query: 1239 --SGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGL-----TFTCHCAQPFW----GPRCE 1287
                  CQ +        C+H G C    GP G       +F C C Q F     G  CE
Sbjct: 1195 LDDNKTCQDI------NECEHPGLC----GPQGECLNTEGSFHCVCQQGFSISADGRTCE 1244

Query: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGP 1322
             +        C     C  T    RC C  G   P
Sbjct: 1245 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAP 1279



 Score =  103 bits (256), Expect = 3e-21
 Identities = 177/747 (23%), Positives = 246/747 (32%), Gaps = 137/747 (18%)

Query: 699  CAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDA--CESQPCRAGGTCSSDGMGF 756
            C  +P  HG            C PG+   R + +  +D   C+ Q     G C +    +
Sbjct: 597  CPKKPSYHGY------NQMMECLPGYK--RVNNTFCQDINECQLQGVCPNGECLNTMGSY 648

Query: 757  HCTCPPGVQGRQCELLSPCTPNP---CEHGGRCESAPG---------------QLPVCSC 798
             CTC  G         S C P+P    E  G C                    QL  CS 
Sbjct: 649  RCTCKIGFGPDPT--FSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV 706

Query: 799  PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG------------YTGPSC 846
             + W GP C++    C  P       IC    G      H              +  P  
Sbjct: 707  GKAW-GPHCEK----CPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKN 761

Query: 847  DQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR----------DVDECLSNP- 895
             Q +      P L          +FS    PG A P  A           D ++    P 
Sbjct: 762  TQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 821

Query: 896  ---CGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRP 952
                 PG  T H+        P + G   E+  P           T     +S S +  P
Sbjct: 822  QPQLSPGISTIHLH-------PQFPGIVIEKTSPPVPVEVAPEAST-----SSASQVIAP 869

Query: 953  GYTGAHCQHEADPCLSRPCLHG-GVCSAAHPGFRCTCLESFTGPQCQTL---VDWCSR-Q 1007
                     E + C   P + G G C      + C C E +   + Q     +D C++ Q
Sbjct: 870  TQVT-----EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQ 924

Query: 1008 PCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDED 1065
               + GRC  T G++ C+CP G+         +   E           +C   G CV+  
Sbjct: 925  HLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRP------DVC-GEGHCVNTV 977

Query: 1066 SSHYC-VCPEG---RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMC-ECLPGYNGDNCE 1120
             +  C  C  G        CE ++D CL         C    G Y C  C  G+ G N +
Sbjct: 978  GAFRCEYCDSGYRMTQRGRCE-DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 1036

Query: 1121 D-DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
              DVDEC        G C +L   Y+CSC  G        +   C        G  C+ N
Sbjct: 1037 CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTP---DHKHCRDIDECQQGNLCV-N 1092

Query: 1180 GTCVDLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
            G C +  G FRCTC  GY       +CE DI+EC+    H      C ++  G F+C+C 
Sbjct: 1093 GQCKNTEGSFRCTCGQGYQLSAAKDQCE-DIDECQHR--HLCAHGQC-RNTEGSFQCVCD 1148

Query: 1236 AGFS----GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW---GPRCER 1288
             G+     G  C+ +    E +     G C  + G     ++ C C   F       C+ 
Sbjct: 1149 QGYRASGLGDHCEDINECLEDKSVCQRGDCINTAG-----SYDCTCPDGFQLDDNKTCQD 1203

Query: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLS----GPSCRSFPGSPPGASNASCAAAPC 1344
            +        C     C  T     C C  G S    G +C          +N  C +   
Sbjct: 1204 INECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC---VNNTVCDSH-- 1258

Query: 1345 LHGGSCRPAPLAPFFRCACAQGWTGPR 1371
               G C     A  FRC C QG+  P+
Sbjct: 1259 ---GFCDNT--AGSFRCLCYQGFQAPQ 1280



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 42/151 (27%), Positives = 59/151 (39%), Gaps = 17/151 (11%)

Query: 1091 QPCQHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
            Q C    +  GY    M ECLPGY   N   C+ D++EC  Q     G C++ +  Y C+
Sbjct: 595  QKCPKKPSYHGY--NQMMECLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCT 651

Query: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV-GGFRCTCPPGYTGLRCEADI 1206
            C    +G   +     C P PP+ S  +    G C  LV  G +C  P     +     +
Sbjct: 652  C---KIGFGPDPTFSSCVPDPPVISEEK----GPCYRLVSSGRQCMHP---LSVHLTKQL 701

Query: 1207 NECRSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
              C  G     H   C       F+ +C  G
Sbjct: 702  CCCSVGKAWGPHCEKCPLPGTAAFKEICPGG 732



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 95/370 (25%), Positives = 136/370 (36%), Gaps = 83/370 (22%)

Query: 590 PCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGF 649
           PC +GG+C    DK  C+CP   TG  C++ +   AS P            Y    QPG 
Sbjct: 406 PCMNGGQCSSR-DK--CQCPPNFTGKLCQIPVHG-ASVP----------KLYQHSQQPGK 451

Query: 650 TGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
              L    I+   + P       V  + G +   PP  +    +   HP       H + 
Sbjct: 452 A--LGTHVIHSTHTLPL-----TVTSQQGVKVKFPPNIVN---IHVKHPPEASVQIHQVS 501

Query: 710 -YDAPGGFRCV-CEPGWSGP-------RCSQSLARDACESQ------PCRAG---GTCSS 751
             D P G +    +PG S         + +Q++       Q      P  A    G C  
Sbjct: 502 RIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQ 561

Query: 752 DGMGFHC-TCPPGVQGRQ--CELLSPCTP-NPCEHGGRCESAPGQLPVCSCPQGWQGPRC 807
           + +G  C    PG+  ++  C  +      N C+   +  S  G   +  C  G++    
Sbjct: 562 ETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNN 621

Query: 808 Q--QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCL---NGG 862
              QD++EC     C P+G C N  GS+ CTC  G+ GP  D   + C P+P +     G
Sbjct: 622 TFCQDINECQLQGVC-PNGECLNTMGSYRCTCKIGF-GP--DPTFSSCVPDPPVISEEKG 677

Query: 863 SCQDGVGSFS--------------CSCLPGFA-GPRCARDVDECLSNPCGPGTCTDHVAS 907
            C   V S                C C  G A GP C    ++C      PGT     A+
Sbjct: 678 PCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHC----EKCPL----PGT-----AA 724

Query: 908 FTCTCPPGYG 917
           F   CP G G
Sbjct: 725 FKEICPGGMG 734



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 143 LCSCPPGYQ--GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200
           +  C PGY+    +   D++EC++   C +G  CLNT GS+RC C  G+      +  VP
Sbjct: 609 MMECLPGYKRVNNTFCQDINECQLQGVCPNG-ECLNTMGSYRCTCKIGFGPDPTFSSCVP 667

Query: 201 CAPSPCRNGGTC 212
             P      G C
Sbjct: 668 DPPVISEEKGPC 679



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 46/166 (27%), Positives = 59/166 (35%), Gaps = 33/166 (19%)

Query: 3   PGARGRRRRR---------RPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGG 53
           PG    R RR         + + PPPPPPP  A P     A PG    P   G P     
Sbjct: 77  PGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARP-----AVPGGQLHPNPGGHPA---- 127

Query: 54  RCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFR 113
                    AA     G    R ++     SG  +   V Q   + G      RC  G+ 
Sbjct: 128 ---------AAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWS 178

Query: 114 GPDCS--LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS 157
               S     P    PC +G  C + P    LC C PG +G++C +
Sbjct: 179 KAPGSQRCTKPSCVPPCQNGGMC-LRPQ---LCVCKPGTKGKACET 220



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 21/91 (23%)

Query: 270 FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW----TGESC-------SQNIDDC 318
           FC +D++ECQLQ   C NG  C NT+G + C C  G+    T  SC       S+    C
Sbjct: 623 FC-QDINECQLQ-GVCPNG-ECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679

Query: 319 ATAV-----CFHGATCHDRVASFYCACPMGK 344
              V     C H  + H  +    C C +GK
Sbjct: 680 YRLVSSGRQCMHPLSVH--LTKQLCCCSVGK 708



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 4/70 (5%)

Query: 720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
           C  GWS    SQ   + +C   PC+ GG C    +   C C PG +G+ CE ++    + 
Sbjct: 173 CCHGWSKAPGSQRCTKPSCVP-PCQNGGMCLRPQL---CVCKPGTKGKACETIAAQDTSS 228

Query: 780 CEHGGRCESA 789
              GG+   A
Sbjct: 229 PVFGGQSPGA 238



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 20/70 (28%)

Query: 165 GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCAC 224
           G  C HG +    PGS RC  P+             C P PC+NGG C +       C C
Sbjct: 170 GGRCCHGWS--KAPGSQRCTKPS-------------CVP-PCQNGGMCLR----PQLCVC 209

Query: 225 LPGFEGQNCE 234
            PG +G+ CE
Sbjct: 210 KPGTKGKACE 219



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 22/109 (20%)

Query: 405 LGRCVN-TQGSFLCQCGRGYTGPRCETDV----------NECLSGPCRNQATCLDRIGQF 453
           LGRC   T GS   QCG+   G   + D           N+C   P +      +++ + 
Sbjct: 556 LGRCFQETIGS---QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMME- 611

Query: 454 TCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF 499
              C+ G+     T+C+ DI+ECQ       G C + +  + CTC  GF
Sbjct: 612 ---CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGF 656



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 15/32 (46%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 477 PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV 508
           PC+NGG C  R     C CP  F+G  CQ+ V
Sbjct: 406 PCMNGGQCSSRDK---CQCPPNFTGKLCQIPV 434



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 14/28 (50%), Positives = 18/28 (64%), Gaps = 1/28 (3%)

Query: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCDI 1035
            PC NGG+C      C CPP ++G+LC I
Sbjct: 406  PCMNGGQCSSRDK-CQCPPNFTGKLCQI 432



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 33/103 (32%), Positives = 35/103 (33%), Gaps = 30/103 (29%)

Query: 2113 GPPASPGGFPLEGPYAAATATAV-------SLAQLGGPGRAGLG--------RQPPGGCV 2157
            GP  + G  PL GP  + T           S A  G P RA  G           PGG  
Sbjct: 35   GPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAA 94

Query: 2158 LSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQL-LNPG 2199
            L                L PP PP P    P  PG QL  NPG
Sbjct: 95   LQ--------------GLRPPPPPPPEPARPAVPGGQLHPNPG 123



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 17/64 (26%)

Query: 971  CLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSG 1030
            C HG   S A    RCT       P C          PCQNGG C++    C+C PG  G
Sbjct: 173  CCHGW--SKAPGSQRCT------KPSCVP--------PCQNGGMCLRP-QLCVCKPGTKG 215

Query: 1031 RLCD 1034
            + C+
Sbjct: 216  KACE 219



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 59/268 (22%), Positives = 89/268 (33%), Gaps = 54/268 (20%)

Query: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGS--------CI 1138
            P    PCQ+GG C   +   +C C PG  G  CE    +  S P   G S          
Sbjct: 189  PSCVPPCQNGGMC---LRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPP 245

Query: 1139 DLVARYLCSCPPGTLGVLCEINEDDCGPGP---------------PLDSGPRCLHNGTCV 1183
            +  A++  S    TL  +  + +      P               PL S    +H+G   
Sbjct: 246  EQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQ 305

Query: 1184 DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243
            + V        P Y   +      +   G+    + +D +  P   F+   H G    R 
Sbjct: 306  EYV------LKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAP---FQLSNHTG----RI 352

Query: 1244 QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC---HCAQPFWGPRCERVARSCRELQCPV 1300
            + V +P   +     G C+ S   G   T      H A           A + R + C  
Sbjct: 353  KVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTL-------TATNFRVVIC-- 403

Query: 1301 GVPCQ---QTPRGPRCACPPGLSGPSCR 1325
             +PC    Q     +C CPP  +G  C+
Sbjct: 404  HLPCMNGGQCSSRDKCQCPPNFTGKLCQ 431



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 3/31 (9%)

Query: 167 PCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197
           PC +GG C +     +CQCP  +TG LC+ P
Sbjct: 406 PCMNGGQCSSRD---KCQCPPNFTGKLCQIP 433



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 6/36 (16%)

Query: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCH 83
           PC NGG+C+   SR+  C CPP + G+ CQ+  P H
Sbjct: 406 PCMNGGQCS---SRDK-CQCPPNFTGKLCQI--PVH 435



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 35/113 (30%), Positives = 42/113 (37%), Gaps = 20/113 (17%)

Query: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYN-- 1115
            GGQ       H    P  + G    Q V   + Q  Q GG  R  +  +  + L G N  
Sbjct: 115  GGQLHPNPGGHPAAAPFTKQG---RQVVRSKVPQETQSGGGSR--LQVHQKQQLQGVNVC 169

Query: 1116 -GDNCEDDVDECASQ---------PCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
             G  C        SQ         PCQ+GG C+      LC C PGT G  CE
Sbjct: 170  GGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCL---RPQLCVCKPGTKGKACE 219



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 58/224 (25%), Positives = 75/224 (33%), Gaps = 26/224 (11%)

Query: 725 SGPRCSQS--LARDACESQPCRAGGTCSSDGMGFHC-----TCPPGVQGRQCELLSPCTP 777
           SGP  S++  +A +A  S+   A G  S    G        T  PG  G   + L P  P
Sbjct: 46  SGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPG--GAALQGLRPPPP 103

Query: 778 NPCEH------GGRCESAPGQLPVCS--CPQGWQGPRCQQDVDECAGPAPCGPHGICTNL 829
            P E       GG+    PG  P  +    QG Q  R +   +  +G            L
Sbjct: 104 PPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQL 163

Query: 830 AGSFSC---TCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
            G   C    CHG    P   +        PC NGG C   +    C C PG  G  C  
Sbjct: 164 QGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMC---LRPQLCVCKPGTKGKACET 220

Query: 887 DVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSP 930
              +  S+P   G      +S+    PP     H      D  P
Sbjct: 221 IAAQDTSSPVFGGQSPGAASSWG---PPEQAAKHTSSKKADTLP 261



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 14/86 (16%)

Query: 189 YTGPLCENPAVPCAPSPCRNGGTCRQSGDLTY---DCACLPGFEGQNCEVNVDDCPGHRC 245
           +T  +C+   V C    C+N  +C +    T    +          N  V +   P   C
Sbjct: 356 FTPSICK---VTCTKGSCQN--SCEKGNTTTLISENGHAADTLTATNFRVVICHLP---C 407

Query: 246 LNGGTCVDGVNTYNCQCPPEWTGQFC 271
           +NGG C    +   CQCPP +TG+ C
Sbjct: 408 MNGGQCS---SRDKCQCPPNFTGKLC 430



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 22/63 (34%), Positives = 24/63 (38%), Gaps = 11/63 (17%)

Query: 1229 GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCE 1287
            G RC CH     P  Q    P    PCQ+GG C RP           C C     G  CE
Sbjct: 170  GGRC-CHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQ---------LCVCKPGTKGKACE 219

Query: 1288 RVA 1290
             +A
Sbjct: 220  TIA 222



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%)

Query: 127 PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRH 170
           PC +G +CS     R  C CPP + G+ C+  V    V +  +H
Sbjct: 406 PCMNGGQCS----SRDKCQCPPNFTGKLCQIPVHGASVPKLYQH 445



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 14/30 (46%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
            PC +GG C    +R  C CPP   G LC+I
Sbjct: 406  PCMNGGQCS---SRDKCQCPPNFTGKLCQI 432



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 36/139 (25%), Positives = 52/139 (37%), Gaps = 31/139 (22%)

Query: 862 GSC-QDGVGSFSCSCLPGFAGPR-CARDV------DECLSNPCGPGTCTDHVASFTCTCP 913
           G C Q+ +GS     LPG +    C   V      ++C   P  P     H  +    C 
Sbjct: 557 GRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSY---HGYNQMMECL 613

Query: 914 PGY---GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHC------- 959
           PGY       C QD+ +C        G C++ + S+ C C+ G+    T + C       
Sbjct: 614 PGYKRVNNTFC-QDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVI 672

Query: 960 QHEADPCL-----SRPCLH 973
             E  PC       R C+H
Sbjct: 673 SEEKGPCYRLVSSGRQCMH 691



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 24/97 (24%), Positives = 40/97 (41%), Gaps = 16/97 (16%)

Query: 224 CLPGFEGQN---CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP----PEWTGQFCTEDVD 276
           CLPG++  N   C+ ++++C        G C++ + +Y C C     P+ T   C  D  
Sbjct: 612 CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670

Query: 277 ECQLQPNACH----NGGTCFNTLGGH----SCVCVNG 305
               +   C+    +G  C + L  H     C C  G
Sbjct: 671 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 707



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 26/72 (36%), Positives = 30/72 (41%), Gaps = 13/72 (18%)

Query: 557 GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVN 616
           GRC  G +      APG    RC      C   PC++GG CL      LC C  GT G  
Sbjct: 171 GRCCHGWSK-----APG--SQRCTKP--SC-VPPCQNGGMCLR---PQLCVCKPGTKGKA 217

Query: 617 CEVNIDDCASNP 628
           CE       S+P
Sbjct: 218 CETIAAQDTSSP 229



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 4/55 (7%)

Query: 926 PDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAA 980
           P C P  C NGG C+       C+C+PG  G  C+  A    S P   G    AA
Sbjct: 189 PSCVPP-CQNGGMCL---RPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAA 239



 Score = 31.6 bits (70), Expect = 9.5
 Identities = 24/77 (31%), Positives = 28/77 (36%), Gaps = 18/77 (23%)

Query: 173 TCLNTPGSFRCQCPAGYTGPLCE------------NPAVPCAPSPCRNGGTCRQSGDLTY 220
           TC  T GS +  C  G T  L              N  V     PC NGG C        
Sbjct: 364 TC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--- 418

Query: 221 DCACLPGFEGQNCEVNV 237
            C C P F G+ C++ V
Sbjct: 419 -CQCPPNFTGKLCQIPV 434


>gi|46249412 latent transforming growth factor beta binding protein 1
            isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  227 bits (578), Expect = 1e-58
 Identities = 237/870 (27%), Positives = 341/870 (39%), Gaps = 146/870 (16%)

Query: 469  DIDECQSSPCVNG-GVCKDRVNGFSCTCPSGFSGSTCQ---LDVDECASTP--CRNGAKC 522
            +I+EC  +P + G G C +    ++C C  G+  S  Q   +D+DEC      C  G +C
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQG-RC 606

Query: 523  VDQPDGYECRCAEGF----EGTLCDRNVDDC-SPDPCHHGRCVDGIASFSCA-CAPGYTG 576
             +    + C C  GF    EGT C  +VD+C  PD C  G CV+ + +F C  C  GY  
Sbjct: 607  ENTEGSFLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 665

Query: 577  T---RCESQVDECRSQPCRHGGKCLDLVDKYLC-RCPSGTTGVNCE-VNIDDCAS-NPCT 630
            T   RCE  +DEC +       +C++    Y C  C  G  G N + +++D+C   N C 
Sbjct: 666  TQRGRCED-IDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCA 724

Query: 631  FGVCRDGINRYDCVCQPGFTGPLCNV---EINECASSPCGEGGSCVDGENGFRCLCPPG- 686
             G C +    Y C C  G+T    +    +I+EC        G C + E  FRC C  G 
Sbjct: 725  NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGY 784

Query: 687  --SLPPLCLPPSHPCAHEP-CSHGICYDAPGGFRCVCEPGWS----GPRCSQSLARDACE 739
              S           C H   C+HG C +  G F+CVC+ G+     G  C      +  E
Sbjct: 785  QLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED--INECLE 842

Query: 740  SQPCRAGGTCSSDGMGFHCTCPPGVQ---GRQCELLSPCT-PNPCEHGGRCESAPGQLPV 795
             +     G C +    + CTCP G Q    + C+ ++ C  P  C   G C +  G    
Sbjct: 843  DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFH- 901

Query: 796  CSCPQGWQ----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ--- 848
            C C QG+     G  C+ D+DEC     C  HG C N AGSF C C+ G+  P   Q   
Sbjct: 902  CVCQQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV 960

Query: 849  DINDCDPNPCLNGGS-CQDGVGSFSCSC---------LPGFAGPRCARDVD--------- 889
            D+N+C+    + G + C++  GSF C C         + G    R + D+D         
Sbjct: 961  DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020

Query: 890  --ECLSNPCGPGTCTD----HVASFTCTCPPGYG-GFHCEQDLPDCSPSSCFNGGTCVDG 942
              EC  N      C +    +V    C C  G G G +CE  +  C           V G
Sbjct: 1021 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCE--IFPCP----------VLG 1068

Query: 943  VNSFSCLCRPG-----------YTGAHCQHEADPCL--SRPCLHGGVCSAAHPGFRCTCL 989
               F+ +C  G             G     +AD CL   +     G C    PG+ C C 
Sbjct: 1069 TAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCK 1128

Query: 990  E-SFTGP---QCQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREA 1043
            + ++  P   QC  + D C        G+CV T G+Y C C         + R +   E+
Sbjct: 1129 QGTYYDPVKLQCFDM-DECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1187

Query: 1044 AAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYM 1103
              QI    E+       C +  S  Y VC     G         CL           G  
Sbjct: 1188 NEQI----EETDVYQDLCWEHLSDEY-VCSRPLVGKQTTYTECCCL----------YGEA 1232

Query: 1104 GGYMCECLPGYNGDNCED--DVDECASQPCQHGGSCIDLVARYLCSCPP-----GTLGVL 1156
             G  C   P  + D+     ++     +      + +D   +Y     P       L   
Sbjct: 1233 WGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSF 1292

Query: 1157 CEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY---TGLRCEADINEC---- 1209
             E+  ++CG    + +G     NG CV +  G+ C C  GY   T      D+NEC    
Sbjct: 1293 EELQAEECG----ILNG---CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELN 1345

Query: 1210 -RSGACHAAHTRDCLQDPGGGFRCLCHAGF 1238
             R   C  A    C+ +  G ++CLC  G+
Sbjct: 1346 NRMSLCKNA---KCI-NTDGSYKCLCLPGY 1371



 Score =  207 bits (527), Expect = 1e-52
 Identities = 278/1059 (26%), Positives = 387/1059 (36%), Gaps = 249/1059 (23%)

Query: 16   SPPPPPPPVRALPLLLLLA----GPGAAAP-----------PCLDGSPCA-NGGRCTQLP 59
            S  PPP P +  P+  L      GPG A P           P LD        G+    P
Sbjct: 442  STHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSP 501

Query: 60   SREAACLCP--PGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117
                  L P  PG V E+     P    P A      S V+A T              +C
Sbjct: 502  GISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSA-SQVIAPTQVTEIN--------EC 552

Query: 118  SL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGG 172
            ++ PD C +  C       +    R+ C C  GY    Q R C  D+DEC   +     G
Sbjct: 553  TVNPDICGAGHC-------INLPVRYTCICYEGYRFSEQQRKC-VDIDECTQVQHLCSQG 604

Query: 173  TCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN 232
             C NT GSF C CPAG+                                   +   EG N
Sbjct: 605  RCENTEGSFLCICPAGF-----------------------------------MASEEGTN 629

Query: 233  CEVNVDDCPGHRCLNGGTCVDGVNTYNCQ-CPPEW--TGQFCTEDVDECQLQPNACHNGG 289
            C ++VD+C        G CV+ V  + C+ C   +  T +   ED+DEC L P+ C +  
Sbjct: 630  C-IDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPD-E 686

Query: 290  TCFNTLGGHSCV-CV---NGWTGESCSQNIDDCATA-VCFHGATCHDRVASFYCACPMGK 344
             C N+ G + CV C     GW G+    ++D+C    VC +G  C +   S+ C+C  G 
Sbjct: 687  QCVNSPGSYQCVPCTEGFRGWNGQCL--DVDECLEPNVCANG-DCSNLEGSYMCSCHKGY 743

Query: 345  TGLLCH-----LDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD---QDVDECS 396
            T    H     +D+    N C      +T    G   CTC  G+   A     +D+DEC 
Sbjct: 744  TRTPDHKHCRDIDECQQGNLCVNGQCKNT---EGSFRCTCGQGYQLSAAKDQCEDIDECQ 800

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECL--SGPCRNQATCLDRI 450
               + C H G+C NT+GSF C C +GY     G  CE D+NECL     C+ +  C++  
Sbjct: 801  -HRHLCAH-GQCRNTEGSFQCVCDQGYRASGLGDHCE-DINECLEDKSVCQ-RGDCINTA 856

Query: 451  GQFTCICMAGF---TGTYCEVDIDECQ-SSPCVNGGVCKDRVNGFSCTCPSGFS----GS 502
            G + C C  GF       C+ DI+EC+    C   G C +    F C C  GFS    G 
Sbjct: 857  GSYDCTCPDGFQLDDNKTCQ-DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGR 915

Query: 503  TCQLDVDECA-STPCRNGAKCVDQPDGYECRCAEGF----EGTLC-DRNVDDCSPDPCHH 556
            TC+ D+DEC  +T C +   C +    + C C +GF    +G  C D N  +     C  
Sbjct: 916  TCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE 974

Query: 557  GRCVDGIASFSCACA---------PGYTGTRCESQVDECRSQPCRHGGKC------LDLV 601
              C +   SF C CA          G   +R  + +D    QP     +C        L 
Sbjct: 975  AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1034

Query: 602  DKYL--------CRCPSGT-TGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGP 652
            D  L        C C SG   G NCE+        PC       G   +  +C  G    
Sbjct: 1035 DNVLAPNVTKQECCCTSGAGWGDNCEI-------FPCPV----LGTAEFTEMCPKG---- 1079

Query: 653  LCNVEINECASSPCGEGGSCVDGEN---GFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
                        P GE  S   GEN      CL                   E C +G C
Sbjct: 1080 --------KGFVPAGESSSEAGGENYKDADECLL---------------FGQEICKNGFC 1116

Query: 710  YDAPGGFRCVCEPG-WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC--PPGVQG 766
             +   G+ C C+ G +  P   Q    D C+       G C +    ++C C  P  +  
Sbjct: 1117 LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDA 1176

Query: 767  RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826
             +   +      P E   + E       +C     W+      D   C+ P       + 
Sbjct: 1177 SEKRCI-----RPAESNEQIEETDVYQDLC-----WEH---LSDEYVCSRPL------VG 1217

Query: 827  TNLAGSFSCTCHGGYTGPSCD----QDIND----CD-PNPCLNGGSCQDGVGSFSCSCLP 877
                 +  C  +G   G  C     +D +D    C+ P         +D +  FS    P
Sbjct: 1218 KQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTP 1277

Query: 878  GFAGPRCARD----------VDEC-LSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ--- 923
              A P   +D           +EC + N C  G C      +TC C   + G+H +    
Sbjct: 1278 E-ADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDC---FDGYHLDTAKM 1333

Query: 924  ---DLPDCSP-----SSCFNGGTCVDGVNSFSCLCRPGY 954
               D+ +C       S C N   C++   S+ CLC PGY
Sbjct: 1334 TCVDVNECDELNNRMSLCKN-AKCINTDGSYKCLCLPGY 1371



 Score =  183 bits (464), Expect = 2e-45
 Identities = 187/653 (28%), Positives = 259/653 (39%), Gaps = 116/653 (17%)

Query: 581  SQVDECRSQPCRHG-GKCLDLVDKYLCRCPSGTTGVNCE---VNIDDCAS--NPCTFGVC 634
            ++++EC   P   G G C++L  +Y C C  G      +   V+ID+C    + C+ G C
Sbjct: 547  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606

Query: 635  RDGINRYDCVCQPGFT----GPLCNVEINECASSP-CGEGGSCVDGENGFRC-LCPPGSL 688
             +    + C+C  GF     G  C ++++EC     CGEG  CV+    FRC  C  G  
Sbjct: 607  ENTEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYR 664

Query: 689  PPL---------CLPPSHPCAHEPCSHGICYDAPGGFRCV-CEPGWSGPRCSQSLARDAC 738
                        CL PS       C    C ++PG ++CV C  G+ G    Q L  D C
Sbjct: 665  MTQRGRCEDIDECLNPS------TCPDEQCVNSPGSYQCVPCTEGFRGWN-GQCLDVDEC 717

Query: 739  ESQPCRAGGTCSSDGMGFHCTCPPGV----QGRQCELLSPCTPNPCEHGGRCESAPGQLP 794
                  A G CS+    + C+C  G       + C  +  C        G+C++  G   
Sbjct: 718  LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFR 777

Query: 795  VCSCPQGWQGPRCQ---QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT----GPSCD 847
             C+C QG+Q    +   +D+DEC     C  HG C N  GSF C C  GY     G  C+
Sbjct: 778  -CTCGQGYQLSAAKDQCEDIDECQHRHLCA-HGQCRNTEGSFQCVCDQGYRASGLGDHCE 835

Query: 848  QDINDC--DPNPCLNGGSCQDGVGSFSCSCLPGFA--GPRCARDVDECLSNP--CGP-GT 900
             DIN+C  D + C  G  C +  GS+ C+C  GF     +  +D++EC  +P  CGP G 
Sbjct: 836  -DINECLEDKSVCQRG-DCINTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGE 892

Query: 901  CTDHVASFTCTCPPGYG----GFHCEQDLPDCSPSS-CFNGGTCVDGVNSFSCLCRPGYT 955
            C +   SF C C  G+     G  CE D+ +C  ++ C + G C +   SF CLC   Y 
Sbjct: 893  CLNTEGSFHCVCQQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLC---YQ 948

Query: 956  GAHCQHEADPCLS-RPC-LHGGVCSAA-----HPGFRCTCLES------FTGPQCQ---- 998
            G     +   C+    C L  GVC  A        F C C +        TG QC+    
Sbjct: 949  GFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTG-QCRSRTS 1007

Query: 999  TLVDWCSRQPCQNGGRCVQ----------------TGAYCLCPPG--WSGRLCDIRSLPC 1040
            T +D    QP +    C                  T   C C  G  W G  C+I   P 
Sbjct: 1008 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGW-GDNCEIFPCPV 1066

Query: 1041 REAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCL--AQPCQHGGT 1098
               A        ++C  G   V    S          G    ++ D CL   Q     G 
Sbjct: 1067 LGTA-----EFTEMCPKGKGFVPAGES------SSEAGGENYKDADECLLFGQEICKNGF 1115

Query: 1099 CRGYMGGYMCECLPGYNGDNCE---DDVDECASQPCQHGGSCIDLVARYLCSC 1148
            C     GY C C  G   D  +    D+DEC        G C++    Y C C
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFC 1168



 Score =  169 bits (429), Expect = 2e-41
 Identities = 204/808 (25%), Positives = 299/808 (37%), Gaps = 167/808 (20%)

Query: 549  CSPDPCHHGRCVDGIASFSCACAPGY---TGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
            C   P +HG       +    C PGY     T C+  ++EC+ Q     G+CL+ +  Y 
Sbjct: 271  CPKKPSYHGY------NQMMECLPGYKRVNNTFCQD-INECQLQGVCPNGECLNTMGSYR 323

Query: 606  CRCPSGTTGVNCEVNIDDCASNPCTF----GVCRDGINRYDCVCQP---GFTGPLCNVEI 658
            C C     G   +     C  +P       G C   ++       P     T  LC   +
Sbjct: 324  CTCK---IGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV 380

Query: 659  NECASSPCGEGGSC-VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFR 717
             +     C +   C + G   F+ +CP G    +         H     G  +  P   +
Sbjct: 381  GKAWGPHCEK---CPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQ 437

Query: 718  CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQ----GRQCELLS 773
             V +     P  ++    +A         G    +      T PP  +     ++   L 
Sbjct: 438  PVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEV----ATAPPEKEIPSLDQEKTKLE 493

Query: 774  PCTP-----------NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ-------QDVDECA 815
            P  P           +P   G   E     +PV   P+       Q        +++EC 
Sbjct: 494  PGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECT 553

Query: 816  -GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ---DINDCDPNPCL-NGGSCQDGVGS 870
              P  CG  G C NL   ++C C+ GY      +   DI++C     L + G C++  GS
Sbjct: 554  VNPDICGA-GHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGS 612

Query: 871  FSCSCLPGFA----GPRCARDVDECLS-NPCGPGTCTDHVASFTCT-CPPGYGGFH---C 921
            F C C  GF     G  C  DVDECL  + CG G C + V +F C  C  GY       C
Sbjct: 613  FLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 671

Query: 922  EQDLPDC-SPSSCFNGGTCVDGVNSFSCL-CRPGYTGAHCQH-EADPCLSRPCLHGGVCS 978
            E D+ +C +PS+C +   CV+   S+ C+ C  G+ G + Q  + D CL       G CS
Sbjct: 672  E-DIDECLNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCS 729

Query: 979  AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL 1038
                 + C+C + +T             + C++   C Q            G LC     
Sbjct: 730  NLEGSYMCSCHKGYTRTP--------DHKHCRDIDECQQ------------GNLC----- 764

Query: 1039 PCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE---QEVDPCLAQPCQH 1095
                                GQC + + S  C C +G   S  +   +++D C  +    
Sbjct: 765  ------------------VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA 806

Query: 1096 GGTCRGYMGGYMCECLPGYN----GDNCEDDVDECASQP--CQHGGSCIDLVARYLCSCP 1149
             G CR   G + C C  GY     GD+CED ++EC      CQ G  CI+    Y C+CP
Sbjct: 807  HGQCRNTEGSFQCVCDQGYRASGLGDHCED-INECLEDKSVCQRG-DCINTAGSYDCTCP 864

Query: 1150 PGTL---GVLCE-INEDD----CGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT--- 1198
             G        C+ INE +    CGP             G C++  G F C C  G++   
Sbjct: 865  DGFQLDDNKTCQDINECEHPGLCGP------------QGECLNTEGSFHCVCQQGFSISA 912

Query: 1199 -GLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257
             G  CE DI+EC +     +H      +  G FRCLC+ GF  P+        + Q C  
Sbjct: 913  DGRTCE-DIDECVNNTVCDSH--GFCDNTAGSFRCLCYQGFQAPQ--------DGQGCVD 961

Query: 1258 GGQCRPSPGPGGGL-------TFTCHCA 1278
              +C    G  G         +F C CA
Sbjct: 962  VNECELLSGVCGEAFCENVEGSFLCVCA 989



 Score =  156 bits (395), Expect = 2e-37
 Identities = 197/739 (26%), Positives = 290/739 (39%), Gaps = 134/739 (18%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVG--ERCQLEDPCHSGPCAGRGVCQSSVVAG 100
            CL+ S C +  +C   P       C  G+ G   +C   D C        G C +     
Sbjct: 677  CLNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL---- 731

Query: 101  TARFSCRCPRGF-RGPD---CSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
               + C C +G+ R PD   C   D C         +C    +G F C+C  GYQ  + +
Sbjct: 732  EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCK-NTEGSFRCTCGQGYQLSAAK 790

Query: 157  S---DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT----GPLCENPAVPCAP--SPCR 207
                D+DEC+    C HG  C NT GSF+C C  GY     G  CE+    C    S C+
Sbjct: 791  DQCEDIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRASGLGDHCED-INECLEDKSVCQ 848

Query: 208  NGGTCRQSGDLTYDCACLPGFE---GQNCEVNVDDC--PGHRCLNGGTCVDGVNTYNCQC 262
             G     +G  +YDC C  GF+    + C+ ++++C  PG  C   G C++   +++C C
Sbjct: 849  RGDCINTAG--SYDCTCPDGFQLDDNKTCQ-DINECEHPG-LCGPQGECLNTEGSFHCVC 904

Query: 263  PPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWT----GESCSQN 314
               ++    G+ C ED+DEC +    C + G C NT G   C+C  G+     G+ C  +
Sbjct: 905  QQGFSISADGRTC-EDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-D 961

Query: 315  IDDCA--TAVCFHGATCHDRVASFYCAC--------PM-GKTGLLCHLD-DACVSNPCHE 362
            +++C   + VC   A C +   SF C C        PM G+       D D  V  P  E
Sbjct: 962  VNECELLSGVCGE-AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020

Query: 363  DAICDTNPVNGRAIC--TCPPGFTGGACDQDVDECSIGAN--------PCEHLGRCVNTQ 412
               C  N +N  ++C     P  T   C      C+ GA         PC  LG    T+
Sbjct: 1021 KKECYYN-LNDASLCDNVLAPNVTKQECC-----CTSGAGWGDNCEIFPCPVLGTAEFTE 1074

Query: 413  GSFLCQCGRGYT---------GPRCETDVNECL---SGPCRNQATCLDRIGQFTCICMAG 460
               +C  G+G+          G     D +ECL      C+N   CL+    + C C  G
Sbjct: 1075 ---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKN-GFCLNTRPGYECYCKQG 1130

Query: 461  FTGTYCE------VDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
               TY +       D+DECQ       G C +    ++C C          LD  E    
Sbjct: 1131 ---TYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMV-----LDASEKRCI 1182

Query: 515  PCRNGAKCVDQPDGYECRCAEGFEGT-LCDRNV---DDCSPDPCHHGRCVDGIA-SFSCA 569
                  + +++ D Y+  C E      +C R +        + C    C+ G A    CA
Sbjct: 1183 RPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECC----CLYGEAWGMQCA 1238

Query: 570  CAP----GYTGTRCESQVDECRSQPCRHGGKCL-DLVDKYLCRCPS---GTTGVNC--EV 619
              P          C   V   R QP  +G   L D  ++Y             +N   E+
Sbjct: 1239 LCPLKDSDDYAQLCNIPVTG-RRQP--YGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1295

Query: 620  NIDDCAS-NPCTFGVCRDGINRYDCVCQPGF---TGPLCNVEINECAS-----SPCGEGG 670
              ++C   N C  G C      Y C C  G+   T  +  V++NEC       S C +  
Sbjct: 1296 QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNA 1354

Query: 671  SCVDGENGFRCLCPPGSLP 689
             C++ +  ++CLC PG +P
Sbjct: 1355 KCINTDGSYKCLCLPGYVP 1373



 Score =  128 bits (322), Expect = 6e-29
 Identities = 182/755 (24%), Positives = 244/755 (32%), Gaps = 164/755 (21%)

Query: 645  CQPGF---TGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAH 701
            C PG+       C  +INEC        G C++    +RC C  G  P    P    C  
Sbjct: 286  CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGFGPD---PTFSSCVP 341

Query: 702  EPC----SHGICYDAPGGFR--------------CVCEPGWS-GPRCSQSLARDACESQP 742
            +P       G CY      R              C C  G + GP C +      C    
Sbjct: 342  DPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEK------CPLPG 395

Query: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEH----GGRCESAPGQLPVCSC 798
              A       GMG+  +   GV  R+          P  H    G          PV   
Sbjct: 396  TAAFKEICPGGMGYTVS---GVHRRR----------PIHHHVGKGPVFVKPKNTQPVAKS 442

Query: 799  PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN-P 857
                  P  ++ V+        GP      +A     T       PS DQ+    +P  P
Sbjct: 443  THPPPLPAKEEPVEALTFSREHGP-----GVAEPEVATAPPEKEIPSLDQEKTKLEPGQP 497

Query: 858  CLNGGSCQ---------------------DGVGSFSCSCLPGFAGPRCARDVDECLSNP- 895
             L+ G                        +     S S       P    +++EC  NP 
Sbjct: 498  QLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPD 557

Query: 896  -CGPGTCTDHVASFTCTCPPGYGGFHCEQ---DLPDCSP-SSCFNGGTCVDGVNSFSCLC 950
             CG G C +    +TC C  GY     ++   D+ +C+      + G C +   SF C+C
Sbjct: 558  ICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCIC 617

Query: 951  RPGYTGAHCQHEADPCLS-RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPC 1009
              G+  +    E   C+    CL   VC   H      C+ +    +C+          C
Sbjct: 618  PAGFMASE---EGTNCIDVDECLRPDVCGEGH------CVNTVGAFRCEY---------C 659

Query: 1010 QNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY 1069
             +G R  Q G                    C +    I   L        QCV+   S+ 
Sbjct: 660  DSGYRMTQRGR-------------------CED----IDECLNPSTCPDEQCVNSPGSYQ 696

Query: 1070 CV-CPEGRTGSHCE-QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDV 1123
            CV C EG  G + +  +VD CL       G C    G YMC C  GY    +  +C  D+
Sbjct: 697  CVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR-DI 755

Query: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183
            DEC        G C +    + C+C     G      +D C           C H G C 
Sbjct: 756  DECQQGNLCVNGQCKNTEGSFRCTCGQ---GYQLSAAKDQCEDIDECQHRHLCAH-GQCR 811

Query: 1184 DLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGF- 1238
            +  G F+C C  GY     G  CE DINEC           DC+ +  G + C C  GF 
Sbjct: 812  NTEGSFQCVCDQGYRASGLGDHCE-DINECLEDK-SVCQRGDCI-NTAGSYDCTCPDGFQ 868

Query: 1239 --SGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGL-----TFTCHCAQPFW----GPRCE 1287
                  CQ +        C+H G C    GP G       +F C C Q F     G  CE
Sbjct: 869  LDDNKTCQDI------NECEHPGLC----GPQGECLNTEGSFHCVCQQGFSISADGRTCE 918

Query: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGP 1322
             +        C     C  T    RC C  G   P
Sbjct: 919  DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAP 953



 Score =  103 bits (256), Expect = 3e-21
 Identities = 177/747 (23%), Positives = 246/747 (32%), Gaps = 137/747 (18%)

Query: 699  CAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDA--CESQPCRAGGTCSSDGMGF 756
            C  +P  HG            C PG+   R + +  +D   C+ Q     G C +    +
Sbjct: 271  CPKKPSYHGY------NQMMECLPGYK--RVNNTFCQDINECQLQGVCPNGECLNTMGSY 322

Query: 757  HCTCPPGVQGRQCELLSPCTPNP---CEHGGRCESAPG---------------QLPVCSC 798
             CTC  G         S C P+P    E  G C                    QL  CS 
Sbjct: 323  RCTCKIGFGPDPT--FSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV 380

Query: 799  PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG------------YTGPSC 846
             + W GP C++    C  P       IC    G      H              +  P  
Sbjct: 381  GKAW-GPHCEK----CPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKN 435

Query: 847  DQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR----------DVDECLSNP- 895
             Q +      P L          +FS    PG A P  A           D ++    P 
Sbjct: 436  TQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 495

Query: 896  ---CGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRP 952
                 PG  T H+        P + G   E+  P           T     +S S +  P
Sbjct: 496  QPQLSPGISTIHLH-------PQFPGIVIEKTSPPVPVEVAPEAST-----SSASQVIAP 543

Query: 953  GYTGAHCQHEADPCLSRPCLHG-GVCSAAHPGFRCTCLESFTGPQCQTL---VDWCSR-Q 1007
                     E + C   P + G G C      + C C E +   + Q     +D C++ Q
Sbjct: 544  TQVT-----EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQ 598

Query: 1008 PCQNGGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDED 1065
               + GRC  T G++ C+CP G+         +   E           +C   G CV+  
Sbjct: 599  HLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRP------DVC-GEGHCVNTV 651

Query: 1066 SSHYC-VCPEG---RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMC-ECLPGYNGDNCE 1120
             +  C  C  G        CE ++D CL         C    G Y C  C  G+ G N +
Sbjct: 652  GAFRCEYCDSGYRMTQRGRCE-DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 710

Query: 1121 D-DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
              DVDEC        G C +L   Y+CSC  G        +   C        G  C+ N
Sbjct: 711  CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTP---DHKHCRDIDECQQGNLCV-N 766

Query: 1180 GTCVDLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
            G C +  G FRCTC  GY       +CE DI+EC+    H      C ++  G F+C+C 
Sbjct: 767  GQCKNTEGSFRCTCGQGYQLSAAKDQCE-DIDECQHR--HLCAHGQC-RNTEGSFQCVCD 822

Query: 1236 AGFS----GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW---GPRCER 1288
             G+     G  C+ +    E +     G C  + G     ++ C C   F       C+ 
Sbjct: 823  QGYRASGLGDHCEDINECLEDKSVCQRGDCINTAG-----SYDCTCPDGFQLDDNKTCQD 877

Query: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLS----GPSCRSFPGSPPGASNASCAAAPC 1344
            +        C     C  T     C C  G S    G +C          +N  C +   
Sbjct: 878  INECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC---VNNTVCDSH-- 932

Query: 1345 LHGGSCRPAPLAPFFRCACAQGWTGPR 1371
               G C     A  FRC C QG+  P+
Sbjct: 933  ---GFCDNT--AGSFRCLCYQGFQAPQ 954



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 42/151 (27%), Positives = 59/151 (39%), Gaps = 17/151 (11%)

Query: 1091 QPCQHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
            Q C    +  GY    M ECLPGY   N   C+ D++EC  Q     G C++ +  Y C+
Sbjct: 269  QKCPKKPSYHGY--NQMMECLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCT 325

Query: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV-GGFRCTCPPGYTGLRCEADI 1206
            C    +G   +     C P PP+ S  +    G C  LV  G +C  P     +     +
Sbjct: 326  C---KIGFGPDPTFSSCVPDPPVISEEK----GPCYRLVSSGRQCMHP---LSVHLTKQL 375

Query: 1207 NECRSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
              C  G     H   C       F+ +C  G
Sbjct: 376  CCCSVGKAWGPHCEKCPLPGTAAFKEICPGG 406



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 95/370 (25%), Positives = 136/370 (36%), Gaps = 83/370 (22%)

Query: 590 PCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGF 649
           PC +GG+C    DK  C+CP   TG  C++ +   AS P            Y    QPG 
Sbjct: 80  PCMNGGQCSSR-DK--CQCPPNFTGKLCQIPVHG-ASVP----------KLYQHSQQPGK 125

Query: 650 TGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
              L    I+   + P       V  + G +   PP  +    +   HP       H + 
Sbjct: 126 A--LGTHVIHSTHTLPL-----TVTSQQGVKVKFPPNIVN---IHVKHPPEASVQIHQVS 175

Query: 710 -YDAPGGFRCV-CEPGWSGP-------RCSQSLARDACESQ------PCRAG---GTCSS 751
             D P G +    +PG S         + +Q++       Q      P  A    G C  
Sbjct: 176 RIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQ 235

Query: 752 DGMGFHC-TCPPGVQGRQ--CELLSPCTP-NPCEHGGRCESAPGQLPVCSCPQGWQGPRC 807
           + +G  C    PG+  ++  C  +      N C+   +  S  G   +  C  G++    
Sbjct: 236 ETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNN 295

Query: 808 Q--QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCL---NGG 862
              QD++EC     C P+G C N  GS+ CTC  G+ GP  D   + C P+P +     G
Sbjct: 296 TFCQDINECQLQGVC-PNGECLNTMGSYRCTCKIGF-GP--DPTFSSCVPDPPVISEEKG 351

Query: 863 SCQDGVGSFS--------------CSCLPGFA-GPRCARDVDECLSNPCGPGTCTDHVAS 907
            C   V S                C C  G A GP C    ++C      PGT     A+
Sbjct: 352 PCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHC----EKCPL----PGT-----AA 398

Query: 908 FTCTCPPGYG 917
           F   CP G G
Sbjct: 399 FKEICPGGMG 408



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 143 LCSCPPGYQ--GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200
           +  C PGY+    +   D++EC++   C +G  CLNT GS+RC C  G+      +  VP
Sbjct: 283 MMECLPGYKRVNNTFCQDINECQLQGVCPNG-ECLNTMGSYRCTCKIGFGPDPTFSSCVP 341

Query: 201 CAPSPCRNGGTC 212
             P      G C
Sbjct: 342 DPPVISEEKGPC 353



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 21/91 (23%)

Query: 270 FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW----TGESC-------SQNIDDC 318
           FC +D++ECQLQ   C NG  C NT+G + C C  G+    T  SC       S+    C
Sbjct: 297 FC-QDINECQLQ-GVCPNG-ECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353

Query: 319 ATAV-----CFHGATCHDRVASFYCACPMGK 344
              V     C H  + H  +    C C +GK
Sbjct: 354 YRLVSSGRQCMHPLSVH--LTKQLCCCSVGK 382



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 22/109 (20%)

Query: 405 LGRCVN-TQGSFLCQCGRGYTGPRCETDV----------NECLSGPCRNQATCLDRIGQF 453
           LGRC   T GS   QCG+   G   + D           N+C   P +      +++ + 
Sbjct: 230 LGRCFQETIGS---QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMME- 285

Query: 454 TCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF 499
              C+ G+     T+C+ DI+ECQ       G C + +  + CTC  GF
Sbjct: 286 ---CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGF 330



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 15/32 (46%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 477 PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV 508
           PC+NGG C  R     C CP  F+G  CQ+ V
Sbjct: 80  PCMNGGQCSSRDK---CQCPPNFTGKLCQIPV 108



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 14/28 (50%), Positives = 18/28 (64%), Gaps = 1/28 (3%)

Query: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCDI 1035
            PC NGG+C      C CPP ++G+LC I
Sbjct: 80   PCMNGGQCSSRDK-CQCPPNFTGKLCQI 106



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 3/31 (9%)

Query: 167 PCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197
           PC +GG C +     +CQCP  +TG LC+ P
Sbjct: 80  PCMNGGQCSSRD---KCQCPPNFTGKLCQIP 107



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 6/36 (16%)

Query: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCH 83
           PC NGG+C+   SR+  C CPP + G+ CQ+  P H
Sbjct: 80  PCMNGGQCS---SRDK-CQCPPNFTGKLCQI--PVH 109



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 14/86 (16%)

Query: 189 YTGPLCENPAVPCAPSPCRNGGTCRQSGDLTY---DCACLPGFEGQNCEVNVDDCPGHRC 245
           +T  +C+   V C    C+N  +C +    T    +          N  V +   P   C
Sbjct: 30  FTPSICK---VTCTKGSCQN--SCEKGNTTTLISENGHAADTLTATNFRVVICHLP---C 81

Query: 246 LNGGTCVDGVNTYNCQCPPEWTGQFC 271
           +NGG C    +   CQCPP +TG+ C
Sbjct: 82  MNGGQCS---SRDKCQCPPNFTGKLC 104



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%)

Query: 127 PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRH 170
           PC +G +CS     R  C CPP + G+ C+  V    V +  +H
Sbjct: 80  PCMNGGQCS----SRDKCQCPPNFTGKLCQIPVHGASVPKLYQH 119



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 14/30 (46%), Positives = 17/30 (56%), Gaps = 3/30 (10%)

Query: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
            PC +GG C    +R  C CPP   G LC+I
Sbjct: 80   PCMNGGQCS---SRDKCQCPPNFTGKLCQI 106



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 36/139 (25%), Positives = 52/139 (37%), Gaps = 31/139 (22%)

Query: 862 GSC-QDGVGSFSCSCLPGFAGPR-CARDV------DECLSNPCGPGTCTDHVASFTCTCP 913
           G C Q+ +GS     LPG +    C   V      ++C   P  P     H  +    C 
Sbjct: 231 GRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSY---HGYNQMMECL 287

Query: 914 PGY---GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHC------- 959
           PGY       C QD+ +C        G C++ + S+ C C+ G+    T + C       
Sbjct: 288 PGYKRVNNTFC-QDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVI 346

Query: 960 QHEADPCL-----SRPCLH 973
             E  PC       R C+H
Sbjct: 347 SEEKGPCYRLVSSGRQCMH 365



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 24/97 (24%), Positives = 40/97 (41%), Gaps = 16/97 (16%)

Query: 224 CLPGFEGQN---CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP----PEWTGQFCTEDVD 276
           CLPG++  N   C+ ++++C        G C++ + +Y C C     P+ T   C  D  
Sbjct: 286 CLPGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344

Query: 277 ECQLQPNACH----NGGTCFNTLGGH----SCVCVNG 305
               +   C+    +G  C + L  H     C C  G
Sbjct: 345 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 381



 Score = 31.6 bits (70), Expect = 9.5
 Identities = 24/77 (31%), Positives = 28/77 (36%), Gaps = 18/77 (23%)

Query: 173 TCLNTPGSFRCQCPAGYTGPLCE------------NPAVPCAPSPCRNGGTCRQSGDLTY 220
           TC  T GS +  C  G T  L              N  V     PC NGG C        
Sbjct: 38  TC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--- 92

Query: 221 DCACLPGFEGQNCEVNV 237
            C C P F G+ C++ V
Sbjct: 93  -CQCPPNFTGKLCQIPV 108


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score =  219 bits (558), Expect = 2e-56
 Identities = 259/1003 (25%), Positives = 366/1003 (36%), Gaps = 198/1003 (19%)

Query: 519  GAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS-PDPCHHGRCVDGIASFSCACAPGYTGT 577
            GA C   P GY+         T C +++++C+ P  C HG C++   S+ C C PG++  
Sbjct: 338  GADC---PQGYK-----RLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388

Query: 578  RCESQVDECRSQPCRHGGKCLDLVD-KYLCRCPSGT--TGVNCEVNIDDCASNPCTFGVC 634
               +Q   C +        C  LV  ++ C+ P  T  T   C  ++       C     
Sbjct: 389  PSRTQ---CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQ-RCP 444

Query: 635  RDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLP----- 689
             DG   +  +C  G    +                   + GE+ F     P   P     
Sbjct: 445  TDGTAAFKEICPAGKGYHILT-----------SHQTLTIQGESDFSLFLHPDGPPKPQQL 493

Query: 690  ---PLCLPP------------------------SHPCAH----EPCSHGICYDAPGGFRC 718
               P   PP                        SHP A      P    I   +P   R 
Sbjct: 494  PESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRW 553

Query: 719  VCEPGWSGPRCSQSLA-RDACESQPCRAG------GTCSSDGMGFHCTCPPGV----QGR 767
               P     R +  +A     E+  CR        G C      + C C PG     Q R
Sbjct: 554  FL-PDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHR 612

Query: 768  QCELLSPCTPNPCEHG-GRCESAPGQLPVCSCPQGWQ-----GPRCQQDVDECAGPAPCG 821
             C  ++ C   PC  G G C +  G    C C +G++     G R   D++ECA P  CG
Sbjct: 613  YCVDVNECEAEPCGPGRGICMNTGGSYN-CHCNRGYRLHVGAGGRSCVDLNECAKPHLCG 671

Query: 822  PHGICTNLAGSFSCTCHGGY----TGPSCDQDINDC-DPNPCLNGGSCQDGVGSFSC-SC 875
              G C N  G + C C+ GY    + P   +DI++C DP+ C + G C++  GSF C +C
Sbjct: 672  DGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPD-GKCENKPGSFKCIAC 730

Query: 876  LPGF--AGPRCARDVDECL-SNPCGPGTCTDHVASFTCTCPPGYG----GFHCEQDLPDC 928
             PG+   G    RDV+EC   +PC PG C +   SF CTC  GY     G  C  D+ +C
Sbjct: 731  QPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDVDEC 789

Query: 929  SPSSCFNGGTCVDGVNSFSCLCRPGY----TGAHCQHEADPCLSRPCLHGGVCSAAHPGF 984
                  + G C +   SF C C  GY      +HC+ + D C       GG C   +  +
Sbjct: 790  EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCE-DIDECDFPAACIGGDCINTNGSY 848

Query: 985  RCTCLESFT---GPQCQTLVDWCSRQP--CQNGGRC--VQTGAYCLCPPGWSGR------ 1031
            RC C +      G +CQ  +D CS+ P  C   G C  +Q    C+C  G++        
Sbjct: 849  RCLCPQGHRLVGGRKCQD-IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGC 907

Query: 1032 --------------------LCD---IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSH 1068
                                 CD     ++  +E    +G      C+     V   +  
Sbjct: 908  EEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967

Query: 1069 YCVCPEGR----------TGSHCEQEVDPCL---AQPCQHGGTCRGYMGGYMCECLPG-- 1113
            + +CP+G+           G    +++D C+   ++ C+  G C     GY C C  G  
Sbjct: 968  HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKE-GKCVNTQPGYECYCKQGFY 1026

Query: 1114 YNGDNCE-DDVDECASQPCQHGGSCIDLVARYLCSC-PPGTLGVL---C----EINEDDC 1164
            Y+G+  E  DVDEC  +     G C +    Y C+C PP         C    E++ D+C
Sbjct: 1027 YDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC 1086

Query: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQ 1224
                     P     G CV+L G +RC C P +       D     S A  A   RD   
Sbjct: 1087 -------QDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCW 1139

Query: 1225 DPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHC------A 1278
               G    +C    +GP   T    C  Q    G QCRP P  G G     HC      +
Sbjct: 1140 SQRGE-DGMCAGPLAGP-ALTFDDCCCRQGRGWGAQCRPCPPRGAG----SHCPTSQSES 1193

Query: 1279 QPFWG---------PRCERVA-RSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFP 1328
              FW          PR E  +     E +C  G  C   P G  C CP G    + R+  
Sbjct: 1194 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG-RCVPRPGGAVCECPGGFQLDASRARC 1252

Query: 1329 GSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371
                     +     C    S R    +  FRC C  G+   R
Sbjct: 1253 VDIDECRELNQRGLLC---KSERCVNTSGSFRCVCKAGFARSR 1292



 Score =  203 bits (517), Expect = 1e-51
 Identities = 211/726 (29%), Positives = 281/726 (38%), Gaps = 113/726 (15%)

Query: 128  CAHGARCSVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHG-GTCLNTPGSFR 182
            C HG  C  GP   + C C PGY    Q R C  DV+EC   EPC  G G C+NT GS+ 
Sbjct: 585  CGHG-ECVPGPPD-YSCHCNPGYRSHPQHRYC-VDVNECEA-EPCGPGRGICMNTGGSYN 640

Query: 183  CQCPAGYT------GPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN---- 232
            C C  GY       G  C +      P  C +GG C       Y C C PG+  +     
Sbjct: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPG-HYKCNCYPGYRLKASRPP 699

Query: 233  -CEVNVDDCPGHRCLNGGTCVDGVNTYNC-QCPPEWTGQF--CTEDVDECQLQPNACHNG 288
             CE ++D+C        G C +   ++ C  C P +  Q      DV+EC  + + C + 
Sbjct: 700  VCE-DIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA-EGSPC-SP 756

Query: 289  GTCFNTLGGHSCVCVNGWT----GESCSQNIDDC-ATAVCFHGATCHDRVASFYCACPMG 343
            G C N  G   C C  G+     G SC  ++D+C A  VC +G  C +   SF C C  G
Sbjct: 757  GWCENLPGSFRCTCAQGYAPAPDGRSCL-DVDECEAGDVCDNGI-CSNTPGSFQCQCLSG 814

Query: 344  K--TGLLCHLDDACVSNPCHEDAIC---DTNPVNGRAICTCPPG--FTGGACDQDVDECS 396
               +    H +D    + C   A C   D    NG   C CP G    GG   QD+DECS
Sbjct: 815  YHLSRDRSHCEDI---DECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECS 871

Query: 397  IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC- 455
               + C   G C N QGS++C C  G+T P  +    E +  P   +   L+      C 
Sbjct: 872  QDPSLCLPHGACKNLQGSYVCVCDEGFT-PTQDQHGCEEVEQPHHKKECYLNFDDTVFCD 930

Query: 456  -ICMAGFTGTYCEVDI-----DECQSSPCVNGGVCKDRVNGFSCTCPSGFS--------- 500
             +     T   C   +     D C+  PC      +     F   CP G           
Sbjct: 931  SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE-----FHSLCPDGKGYTQDNNIVN 985

Query: 501  -GSTCQLDVDEC---ASTPCRNGAKCVDQPDGYECRCAEGF--EGTLCD-RNVDDCSPDP 553
             G     D+DEC    S  C+ G KCV+   GYEC C +GF  +G L +  +VD+C  + 
Sbjct: 986  YGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044

Query: 554  -CHHGRCVDGIASFSCACAP----GYTGTRC----ESQVDECRSQPCRHGGKCLDLVDKY 604
             C +G C +    + CAC P         +C    E  VDEC+       G+C++L   Y
Sbjct: 1045 NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSY 1104

Query: 605  LCRC----PSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE 660
             C C      G +G +C++        P    VC       D +C     GP    + + 
Sbjct: 1105 RCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE-DGMCAGPLAGPALTFD-DC 1162

Query: 661  CASSPCGEGGSCVD-GENGFRCLCPPG--------SLPPLCL--PPSHPCAHEP------ 703
            C     G G  C      G    CP             PL L  PP    + E       
Sbjct: 1163 CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR 1222

Query: 704  CSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG------TCSSDGMGFH 757
            C  G C   PGG  C C PG      S++   D  E +     G       C +    F 
Sbjct: 1223 CVSGRCVPRPGGAVCEC-PGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281

Query: 758  CTCPPG 763
            C C  G
Sbjct: 1282 CVCKAG 1287



 Score =  167 bits (422), Expect = 1e-40
 Identities = 191/724 (26%), Positives = 269/724 (37%), Gaps = 217/724 (29%)

Query: 53   GRCTQLPSREAACLCPPGWVGER----CQLEDPCHSGPCA-GRGVCQSSVVAGTARFSCR 107
            G C   P  + +C C PG+        C   + C + PC  GRG+C ++       ++C 
Sbjct: 588  GECVPGPP-DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT----GGSYNCH 642

Query: 108  CPRGFR------GPDCSLPDPCLSSP-CAHGARCSVGPDGRFLCSCPPGYQGRSCR---- 156
            C RG+R      G  C   + C     C  G  C   P G + C+C PGY+ ++ R    
Sbjct: 643  CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFP-GHYKCNCYPGYRLKASRPPVC 701

Query: 157  SDVDECRVGEPCRHGGTCLNTPGSFRC-QCPAGYT---GPLCEN-----PAVPCAPSPCR 207
             D+DECR    C  G  C N PGSF+C  C  GY    G  C +        PC+P  C 
Sbjct: 702  EDIDECRDPSSCPDG-KCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760

Query: 208  N------------------GGTCR-----QSGDL-----------TYDCACLPGF----E 229
            N                  G +C      ++GD+           ++ C CL G+    +
Sbjct: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 820

Query: 230  GQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT---GQFCTEDVDECQLQPNACH 286
              +CE ++D+C       GG C++   +Y C CP       G+ C +D+DEC   P+ C 
Sbjct: 821  RSHCE-DIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCL 878

Query: 287  NGGTCFNTLGGHSCVCVNGWTG----------------ESCSQNIDDC-------ATAV- 322
              G C N  G + CVC  G+T                 + C  N DD        AT V 
Sbjct: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVT 938

Query: 323  -----CFHGATCHDRV----------ASFYCACPMGKT----------GLLCHLD-DACV 356
                 C  GA   D            A F+  CP GK           G+  H D D C+
Sbjct: 939  QQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECM 998

Query: 357  ---SNPCHEDAICDTNPVNGRAICTCPPGF--TGGACD-QDVDECSIGANPCEHLGRCVN 410
               S  C E    +T P      C C  GF   G   +  DVDEC   +N C + G C N
Sbjct: 999  LFGSEICKEGKCVNTQPGYE---CYCKQGFYYDGNLLECVDVDECLDESN-CRN-GVCEN 1053

Query: 411  TQGSFLCQCG---------RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCIC---- 457
            T+G + C C          R    P  E DV+EC          C++  G + C C    
Sbjct: 1054 TRGGYRCACTPPAEYSPAQRQCLSPE-EMDVDECQDPAACRPGRCVNLPGSYRCECRPPW 1112

Query: 458  MAGFTGTYCEVDIDECQSSP-----CVN----GGVCKDRVNGFSCT-------------- 494
            + G +G  C++     + +P     C +     G+C   + G + T              
Sbjct: 1113 VPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGA 1172

Query: 495  ----CPSGFSGSTC----------------------------QLDVDECASTPCRNGAKC 522
                CP   +GS C                            + D DEC    C +G +C
Sbjct: 1173 QCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR---CVSG-RC 1228

Query: 523  VDQPDGYECRCAEGFEGTLCDR---NVDDCSPDP-----CHHGRCVDGIASFSCACAPGY 574
            V +P G  C C  GF+         ++D+C         C   RCV+   SF C C  G+
Sbjct: 1229 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288

Query: 575  TGTR 578
              +R
Sbjct: 1289 ARSR 1292



 Score =  100 bits (249), Expect = 2e-20
 Identities = 120/445 (26%), Positives = 160/445 (35%), Gaps = 87/445 (19%)

Query: 45   DGSPCANGGRCTQLPSREAACLCPPGWVGERCQ-----LEDPCHSGPCA----GRGVCQS 95
            D S C   G C  L      C+C  G+   + Q     +E P H   C         C S
Sbjct: 873  DPSLCLPHGACKNLQG-SYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDS 931

Query: 96   SVVAGTARFSCRCPRGFR-GPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ-- 151
             +     +  C C  G   G  C + P P  SS   H    S+ PDG+       GY   
Sbjct: 932  VLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH----SLCPDGK-------GYTQD 980

Query: 152  ------GRSCRSDVDECRV--GEPCRHGGTCLNTPGSFRCQCPAG--YTGPLCENPAVP- 200
                  G     D+DEC +   E C+ G  C+NT   + C C  G  Y G L E   V  
Sbjct: 981  NNIVNYGIPAHRDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039

Query: 201  -CAPSPCRNGGTCRQSGDLTYDCACLPGFE----GQNC----EVNVDDCPGHRCLNGGTC 251
                S CRNG      G   Y CAC P  E     + C    E++VD+C        G C
Sbjct: 1040 CLDESNCRNGVCENTRGG--YRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRC 1097

Query: 252  VDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNG----GTCFNTLGGHSCVCVNGWT 307
            V+   +Y C+C P W       D   CQL  +           C++  G    +C     
Sbjct: 1098 VNLPGSYRCECRPPWVPGPSGRD---CQLPESPAERAPERRDVCWSQRGEDG-MCAGPLA 1153

Query: 308  GESCSQNIDDCATAVCFHGA-------TCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360
            G + +   DDC    C  G         C  R A  +C     ++          +  P 
Sbjct: 1154 GPALT--FDDCC---CRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPP 1208

Query: 361  HEDAICDTN------------PVNGRAICTCPPGFTGGACDQ---DVDEC---SIGANPC 402
             ++   + +            P  G A+C CP GF   A      D+DEC   +     C
Sbjct: 1209 RDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLC 1268

Query: 403  EHLGRCVNTQGSFLCQCGRGYTGPR 427
            +   RCVNT GSF C C  G+   R
Sbjct: 1269 KS-ERCVNTSGSFRCVCKAGFARSR 1292



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 64/219 (29%), Positives = 75/219 (34%), Gaps = 66/219 (30%)

Query: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWV----GERCQL-------------------- 78
            C D + C   GRC  LP     C C P WV    G  CQL                    
Sbjct: 1086 CQDPAAC-RPGRCVNLPG-SYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG 1143

Query: 79   EDPCHSGPCAGRGVCQSSVVAGTAR---FSCR-CPRGFRGPDCSLPDP-----------C 123
            ED   +GP AG  +          R     CR CP    G  C                 
Sbjct: 1144 EDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1203

Query: 124  LSSP---------------CAHGARCSVGPDGRFLCSCPPGYQGRSCRS---DVDECRV- 164
            L  P               C  G RC   P G  +C CP G+Q  + R+   D+DECR  
Sbjct: 1204 LGKPPRDEDSSEEDSDECRCVSG-RCVPRPGGA-VCECPGGFQLDASRARCVDIDECREL 1261

Query: 165  ---GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP 200
               G  C+    C+NT GSFRC C AG+         VP
Sbjct: 1262 NQRGLLCK-SERCVNTSGSFRCVCKAGFARSRPHGACVP 1299



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 40/121 (33%), Positives = 55/121 (45%), Gaps = 24/121 (19%)

Query: 79  EDPCHSGPCAG---RGVCQSSVVAGTARFSC-RCPRGFRGPDCSLPDPCLSSPCAHGARC 134
           + PC S P  G   +  C  S+     +  C +CP+  +      P P          R 
Sbjct: 286 KQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQ-LQYTGVQKPGP---------VRG 335

Query: 135 SVGPDGRFLCSCPPGYQGRSCR--SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT-G 191
            VG D      CP GY+  +     D++EC +   CRHG  CLN PGS+RC CP G++ G
Sbjct: 336 EVGAD------CPQGYKRLNSTHCQDINECAMPGVCRHGD-CLNNPGSYRCVCPPGHSLG 388

Query: 192 P 192
           P
Sbjct: 389 P 389



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 87/354 (24%), Positives = 111/354 (31%), Gaps = 92/354 (25%)

Query: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVA-GTARFSC 106
           PC NGG+C    S    CLCPP + G  CQ+      G   G G   S   A  T     
Sbjct: 116 PCMNGGQC----SSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPP 171

Query: 107 RCPRGFRGPD----------CSLPDPCLSSPCAHGA-RCSVGPDGRFLCSC--------- 146
             P G                  P P    P  H A    +GP G+              
Sbjct: 172 LAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGP-GQISAEVQAPPPVVNV 230

Query: 147 ----PPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN---PAV 199
               PP    +  R +        P +H    L  P     + P       C     P  
Sbjct: 231 RVHHPPEASVQVHRIESSNAESAAPSQH---LLPHPKPSHPRPPTQKPLGRCFQDTLPKQ 287

Query: 200 PCAPSP----------CRNGGT------CRQSGDLTYDCACLPGFEGQNCEVNVDDCPGH 243
           PC  +P          C + GT      C +   L Y     PG      EV  D   G+
Sbjct: 288 PCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPG--PVRGEVGADCPQGY 345

Query: 244 RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCV 303
           + LN   C                     +D++EC + P  C + G C N  G + CVC 
Sbjct: 346 KRLNSTHC---------------------QDINECAM-PGVCRH-GDCLNNPGSYRCVCP 382

Query: 304 NGWT-GESCSQNIDD-------CATAV-----CFHGATCHDRVASFYCACPMGK 344
            G + G S +Q I D       C   V     C H  T   R+    C C +GK
Sbjct: 383 PGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT--TRLTRQLCCCSVGK 434



 Score = 41.6 bits (96), Expect = 0.009
 Identities = 39/148 (26%), Positives = 53/148 (35%), Gaps = 21/148 (14%)

Query: 1094 QHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPP 1150
            Q  G  RG +G    +C  GY   N  +C+D ++ECA       G C++    Y C CPP
Sbjct: 328  QKPGPVRGEVGA---DCPQGYKRLNSTHCQD-INECAMPGVCRHGDCLNNPGSYRCVCPP 383

Query: 1151 GTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRCEADINEC 1209
            G             GP        +      C  LV    +C  P      R    +  C
Sbjct: 384  G----------HSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHP---LTTRLTRQLCCC 430

Query: 1210 RSGACHAAHTRDCLQDPGGGFRCLCHAG 1237
              G    A  + C  D    F+ +C AG
Sbjct: 431  SVGKAWGARCQRCPTDGTAAFKEICPAG 458



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 11/74 (14%)

Query: 969  RPCLHGGVCSAAHPGFRCTCL-------ESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021
            R CL G    +   G   T +       ++ TG   + +V      PC NGG+C      
Sbjct: 73   RTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVV---CPLPCMNGGQCSSRNQ- 128

Query: 1022 CLCPPGWSGRLCDI 1035
            CLCPP ++GR C +
Sbjct: 129  CLCPPDFTGRFCQV 142



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 18/79 (22%)

Query: 435 CLSGPCRNQA------TCLDRIGQFT-CICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR 487
           CL G CR+        T +   G  T  +  +GF    C +        PC+NGG C  R
Sbjct: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPL--------PCMNGGQCSSR 126

Query: 488 VNGFSCTCPSGFSGSTCQL 506
                C CP  F+G  CQ+
Sbjct: 127 ---NQCLCPPDFTGRFCQV 142



 Score = 38.1 bits (87), Expect = 0.10
 Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 17/77 (22%)

Query: 201 CAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV------NVDDCPGHRCLNGGTCVDG 254
           C    CR+  +C+Q  ++T     L G  G + +        V  CP   C+NGG C   
Sbjct: 75  CLKGQCRD--SCQQGSNMT-----LIGENGHSTDTLTGSGFRVVVCP-LPCMNGGQCS-- 124

Query: 255 VNTYNCQCPPEWTGQFC 271
            +   C CPP++TG+FC
Sbjct: 125 -SRNQCLCPPDFTGRFC 140



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 53/186 (28%), Positives = 66/186 (35%), Gaps = 48/186 (25%)

Query: 27  LPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSRE------AACLCPPGWVGERCQLED 80
           L LLLLL G G        G   A GG      +RE      A  +C    +  +C+  D
Sbjct: 28  LLLLLLLLGLGGRVEGGPAGERGAGGGGAL---ARERFKVVFAPVICKRTCLKGQCR--D 82

Query: 81  PCHSGP---CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVG 137
            C  G      G     +  + G+         GFR   C LP       C +G +CS  
Sbjct: 83  SCQQGSNMTLIGENGHSTDTLTGS---------GFRVVVCPLP-------CMNGGQCS-- 124

Query: 138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENP 197
              R  C CPP + GR        C+V      GGT  + PG  R       TG L    
Sbjct: 125 --SRNQCLCPPDFTGRF-------CQVPAGGAGGGTGGSGPGLSR-------TGALSTGA 168

Query: 198 AVPCAP 203
             P AP
Sbjct: 169 LPPLAP 174



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 75/299 (25%), Positives = 90/299 (30%), Gaps = 70/299 (23%)

Query: 639 NRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHP 698
           +R  C+C P FTG  C V        P G  G    G      L   G+L    LPP  P
Sbjct: 125 SRNQCLCPPDFTGRFCQV--------PAGGAGGGTGGSGPG--LSRTGALSTGALPPLAP 174

Query: 699 CAHEPCSHGICY------DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD 752
                 S    Y      D PG       PG  GP    +            A       
Sbjct: 175 EGDSVASKHAIYAVQVIADPPG-------PG-EGPPAQHAAFLVPLGPGQISAEVQAPPP 226

Query: 753 GMGFHCTCPP--GVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD 810
            +      PP   VQ  + E  +  +  P +H           P    P G    RC QD
Sbjct: 227 VVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLG----RCFQD 282

Query: 811 V---DEC-AGPAP--------CGPHGI---------CTNLA-----------GSFSCTCH 838
                 C + P P        CG  G          C  L            G     C 
Sbjct: 283 TLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCP 342

Query: 839 GGY---TGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA-GP---RCARDVDE 890
            GY       C QDIN+C        G C +  GS+ C C PG + GP   +C  D  E
Sbjct: 343 QGYKRLNSTHC-QDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 33/106 (31%), Positives = 44/106 (41%), Gaps = 25/106 (23%)

Query: 495 CPSGFS--GSTCQLDVDECASTP-CRNGAKCVDQPDGYECRCAEGF-------------- 537
           CP G+    ST   D++ECA    CR+G  C++ P  Y C C  G               
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKP 399

Query: 538 -EGTLCDRNVDDCSPD-PCHHGRCVDGIASFSCACAPGYT-GTRCE 580
            E +LC R V   SP+  C H      +    C C+ G   G RC+
Sbjct: 400 EEKSLCFRLV---SPEHQCQH-PLTTRLTRQLCCCSVGKAWGARCQ 441



 Score = 35.0 bits (79), Expect = 0.86
 Identities = 29/91 (31%), Positives = 34/91 (37%), Gaps = 11/91 (12%)

Query: 704 CSHGICYDA---PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC 760
           C  G C D+         + E G S    + S  R      PC  GG CSS      C C
Sbjct: 75  CLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQ---CLC 131

Query: 761 PPGVQGRQCELLSPCTPNPCEHGGRCESAPG 791
           PP   GR C++     P     GG   S PG
Sbjct: 132 PPDFTGRFCQV-----PAGGAGGGTGGSGPG 157



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 37/130 (28%), Positives = 48/130 (36%), Gaps = 28/130 (21%)

Query: 2141 GGPGRAGLGRQPPGGCVLSLGLLNPVAVPLD--------WARLPPPAPPGP--------- 2183
            GG G +G G    G   LS G L P+A   D        +A      PPGP         
Sbjct: 149  GGTGGSGPGLSRTGA--LSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHA 206

Query: 2184 SFLLPLAPGPQLLNPGTPVSPQ-ERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEH 2242
            +FL+PL PG         +S + + PPP + V  H     +   H           PS+H
Sbjct: 207  AFLVPLGPGQ--------ISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQH 258

Query: 2243 PYLTPSPESP 2252
                P P  P
Sbjct: 259  LLPHPKPSHP 268



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 10/72 (13%)

Query: 412 QGSFLCQCGRGY---TGPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGF----TG 463
           +G     C +GY       C+ D+NEC + G CR+   CL+  G + C+C  G     + 
Sbjct: 334 RGEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRH-GDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 464 TYCEVDIDECQS 475
           T C  D  E +S
Sbjct: 392 TQCIADKPEEKS 403



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 15/37 (40%), Positives = 17/37 (45%), Gaps = 4/37 (10%)

Query: 199 VPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEV 235
           V   P PC NGG C         C C P F G+ C+V
Sbjct: 110 VVVCPLPCMNGGQCSSRN----QCLCPPDFTGRFCQV 142



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 4/51 (7%)

Query: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNG 1180
            PC +GG C    +R  C CPP   G  C++     G G    SGP     G
Sbjct: 116  PCMNGGQCS---SRNQCLCPPDFTGRFCQVPAGGAGGGTG-GSGPGLSRTG 162



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 2196 LNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPES--PE 2253
            L+P  P  PQ+ P      P   +     G  +  P +    V   HP  T +P    PE
Sbjct: 482  LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPE 541

Query: 2254 HWASPSPPSLSDWSESTPSPATA 2276
              + PSPP++  +    P   +A
Sbjct: 542  LISRPSPPTMRWFLPDLPPSRSA 564



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 3/31 (9%)

Query: 930 PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
           P  C NGG C    +   CLC P +TG  CQ
Sbjct: 114 PLPCMNGGQCS---SRNQCLCPPDFTGRFCQ 141



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 49/199 (24%), Positives = 74/199 (37%), Gaps = 28/199 (14%)

Query: 386 GACDQD-VDECSIGANPCEHLGRCVNTQGSFLCQCGRG--YTGPRCE-TDVNECLSGPCR 441
           G C QD + +   G+NP   L +  +  GS     G+   +  P+ + T V +   GP R
Sbjct: 277 GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--PGPVR 334

Query: 442 NQATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498
                    G+    C  G+     T+C+ DI+EC        G C +    + C CP G
Sbjct: 335 ---------GEVGADCPQGYKRLNSTHCQ-DINECAMPGVCRHGDCLNNPGSYRCVCPPG 384

Query: 499 FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR 558
            S    +    +C +      + C  +    E +C      T   R +  CS       R
Sbjct: 385 HSLGPSR---TQCIADKPEEKSLCF-RLVSPEHQCQHPLT-TRLTRQLCCCSVGKAWGAR 439

Query: 559 C----VDGIASFSCACAPG 573
           C     DG A+F   C  G
Sbjct: 440 CQRCPTDGTAAFKEICPAG 458


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.482 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 131,827,554
Number of Sequences: 37866
Number of extensions: 8863796
Number of successful extensions: 93744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 1482
Number of HSP's that attempted gapping in prelim test: 30683
Number of HSP's gapped (non-prelim): 25981
length of query: 2321
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2202
effective length of database: 13,741,464
effective search space: 30258703728
effective search space used: 30258703728
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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