BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens] (392 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens] 796 0.0 gi|19913369 transducin beta-like 3 [Homo sapiens] 92 1e-18 gi|16554629 WD repeat domain 5 [Homo sapiens] 87 3e-17 gi|16554627 WD repeat domain 5 [Homo sapiens] 87 3e-17 gi|32189425 WD repeat domain 69 [Homo sapiens] 85 1e-16 gi|23199987 WD repeat domain 5B [Homo sapiens] 84 3e-16 gi|21071067 TBP-associated factor 5 [Homo sapiens] 80 4e-15 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 78 1e-14 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 77 2e-14 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 77 2e-14 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 77 2e-14 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 76 6e-14 gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 74 2e-13 gi|157266266 WD repeat domain 86 [Homo sapiens] 74 3e-13 gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 73 5e-13 gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 71 2e-12 gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 71 2e-12 gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 71 2e-12 gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 71 2e-12 gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 71 2e-12 gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 70 4e-12 gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 69 6e-12 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 69 7e-12 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 69 7e-12 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 69 7e-12 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 69 7e-12 gi|13376840 WD repeat domain 61 [Homo sapiens] 69 7e-12 gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 69 1e-11 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 68 1e-11 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 68 2e-11 >gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens] Length = 392 Score = 796 bits (2057), Expect = 0.0 Identities = 392/392 (100%), Positives = 392/392 (100%) Query: 1 MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN 60 MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN Sbjct: 1 MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN 60 Query: 61 EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ 120 EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ Sbjct: 61 EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ 120 Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL Sbjct: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180 Query: 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ Sbjct: 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240 Query: 241 MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD 300 MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD Sbjct: 241 MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD 300 Query: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA 360 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA Sbjct: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA 360 Query: 361 DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL 392 DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL Sbjct: 361 DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL 392 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 91.7 bits (226), Expect = 1e-18 Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 17/200 (8%) Query: 86 TFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPS 145 T R H K I + I+ L + S D T K+W +L V GH + C +F P Sbjct: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPM 532 Query: 146 GLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205 V+ + D +K+W+ +D SC+ TF+GH +L A V RG ++S+ DG +LW Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592 Query: 206 GRSACLGVL---------ADCGSSINGVAVGAADNSINL--------GSPEQMPSEREVG 248 + C+ L C + GA+D+ + L + EQ E +V Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652 Query: 249 TEAKMLLLAREDKKLQCLGL 268 + ++ L E + L+ LGL Sbjct: 653 RQQELDNLLHEKRYLRALGL 672 Score = 61.6 bits (148), Expect = 1e-09 Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 21/311 (6%) Query: 90 IHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP--SGL 147 IHT + + L + DG +++W G V+ F P + L Sbjct: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166 Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207 ++ S DA +++WS +D SC+ H + A G ++S+ RD +WD Sbjct: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD--- 223 Query: 208 SACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLG 267 L C ++ + + ++ L PE+ S+ V + L A + L+ Sbjct: 224 ------LQSCQATRTVPVFESVEAAVLL--PEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275 Query: 268 LQSRQLVFLFI-----GSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSG 322 S Q V+ G + +C + ++L T D N+ + RS R Q S Sbjct: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335 Query: 323 APV-LSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEK--QIYTCC 379 + + L D + + C V + ++ D V + + K +C Sbjct: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCA 395 Query: 380 RDGLVRRYQLS 390 +D VR ++++ Sbjct: 396 KDQSVRIWRMN 406 Score = 33.5 bits (75), Expect = 0.34 Identities = 46/208 (22%), Positives = 82/208 (39%), Gaps = 25/208 (12%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIW---SAE 164 V +S +K+++ + +L GH V F G + S D ++IW A Sbjct: 351 VVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAG 409 Query: 165 DASCVVTFKGHKGGILDTAIVDRGRN--VVSASRDGTARLWDCGRSACLGVLADCGSSIN 222 CV GH + T R + +V+ S+D T +LW ++ +L+ + N Sbjct: 410 QVMCVAQGSGHTHSV-GTVCCSRLKESFLVTGSQDCTVKLWPLPKA----LLSKNTAPDN 464 Query: 223 GVAVGAADNSINLGSPEQMPSEREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLF 277 G + A + Q ++++ + A K+L +D+ + L QL+ +F Sbjct: 465 GPILLQAQTT-------QRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVF 517 Query: 278 IGSDAFNCCTFLSGF--LLLAGTQDGNI 303 G C S +L + DG I Sbjct: 518 SGHRRGLWCVQFSPMDQVLATASADGTI 545 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 86.7 bits (213), Expect = 3e-17 Identities = 44/126 (34%), Positives = 63/126 (50%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I+ + SS L VS+S D T+KIW S+G+ + L+GH V CC F P +++ Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D ++IW + C+ T H + G +VS+S DG R+WD C Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 Query: 211 LGVLAD 216 L L D Sbjct: 206 LKTLID 211 Score = 73.9 bits (180), Expect = 2e-13 Identities = 38/134 (28%), Positives = 61/134 (45%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HTK+++ + S G SSS D +KIW A +G+ + + GH ++ + +++ Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S D LKIW C+ T KGH + + +VS S D + R+WD C Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163 Query: 211 LGVLADCGSSINGV 224 L L ++ V Sbjct: 164 LKTLPAHSDPVSAV 177 Score = 64.7 bits (156), Expect = 1e-10 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149 H+ ++ + + G L VSSS DG +IW ++G+ L+ +++ V+ +F P+G + Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204 L+ +D LK+W C+ T+ GHK I V G+ +VS S D +W+ Sbjct: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 Score = 61.6 bits (148), Expect = 1e-09 Identities = 35/92 (38%), Positives = 44/92 (47%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N L+ L GH V+ +F P+G + S D +KIW A D T GHK GI D Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 A +VSAS D T ++WD CL L Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 Score = 45.8 bits (107), Expect = 7e-05 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 7/118 (5%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151 ++ + S G ++++ D T+K+W S G+ + GH + C F G ++S Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW--DC 205 G D + IW+ + V +GH ++ TA + SA+ D T +LW DC Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 86.7 bits (213), Expect = 3e-17 Identities = 44/126 (34%), Positives = 63/126 (50%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I+ + SS L VS+S D T+KIW S+G+ + L+GH V CC F P +++ Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D ++IW + C+ T H + G +VS+S DG R+WD C Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 Query: 211 LGVLAD 216 L L D Sbjct: 206 LKTLID 211 Score = 73.9 bits (180), Expect = 2e-13 Identities = 38/134 (28%), Positives = 61/134 (45%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HTK+++ + S G SSS D +KIW A +G+ + + GH ++ + +++ Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S D LKIW C+ T KGH + + +VS S D + R+WD C Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163 Query: 211 LGVLADCGSSINGV 224 L L ++ V Sbjct: 164 LKTLPAHSDPVSAV 177 Score = 64.7 bits (156), Expect = 1e-10 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149 H+ ++ + + G L VSSS DG +IW ++G+ L+ +++ V+ +F P+G + Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204 L+ +D LK+W C+ T+ GHK I V G+ +VS S D +W+ Sbjct: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 Score = 61.6 bits (148), Expect = 1e-09 Identities = 35/92 (38%), Positives = 44/92 (47%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N L+ L GH V+ +F P+G + S D +KIW A D T GHK GI D Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 A +VSAS D T ++WD CL L Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 Score = 45.8 bits (107), Expect = 7e-05 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 7/118 (5%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151 ++ + S G ++++ D T+K+W S G+ + GH + C F G ++S Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW--DC 205 G D + IW+ + V +GH ++ TA + SA+ D T +LW DC Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 84.7 bits (208), Expect = 1e-16 Identities = 54/214 (25%), Positives = 92/214 (42%), Gaps = 23/214 (10%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 R H+ I L ++ G ++ S D T+ +W A G +L GH +++ F + Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275 Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208 +L+G MD K+W A + CV T GH ILD+ G+ + +AS DGTAR++ Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335 Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGL 268 C+ L I+ ++ N + GS DK + Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGS---------------------SDKTARIWDA 374 Query: 269 QSRQLVFLFIG--SDAFNCCTFLSGFLLLAGTQD 300 Q+ Q + + G + F+C G +++ G++D Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408 Score = 70.1 bits (170), Expect = 3e-12 Identities = 43/150 (28%), Positives = 68/150 (45%), Gaps = 1/150 (0%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFF-PSGL 147 + H +T + ++ G ++ S D T K+W ++GE LEGH V F P G Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148 Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207 + +G D K+WS E C TF+GH I+ + + V + S D TA+LWD Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208 Query: 208 SACLGVLADCGSSINGVAVGAADNSINLGS 237 + L + I ++ + + I GS Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGS 238 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 2/108 (1%) Query: 96 TCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMD 155 +C D + G L ++S DGT +I+ A+ + LEGH +++ F P G +L+G D Sbjct: 309 SCFDYT--GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366 Query: 156 AQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 +IW A+ C+ +GH I A +G V++ S+D T R+W Sbjct: 367 KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 67.8 bits (164), Expect = 2e-11 Identities = 46/195 (23%), Positives = 77/195 (39%), Gaps = 23/195 (11%) Query: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168 + S D T K+W G+ GH ++ C F P +V +G MD K+W ++ Sbjct: 152 TGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE 211 Query: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228 V T +GH I+ + G +++ S D T +WD AD G +N Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----------ADTGRKVN------ 255 Query: 229 ADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSD--AFNCC 286 I +G ++ S + ++L DK + + + V G D + C Sbjct: 256 ----ILIGHCAEI-SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310 Query: 287 TFLSGFLLLAGTQDG 301 +G L+ + DG Sbjct: 311 FDYTGKLIATASADG 325 Score = 51.2 bits (121), Expect = 2e-06 Identities = 23/71 (32%), Positives = 39/71 (54%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I+ + + +G ++ S+D T +IW A G+ +VLEGH ++ C F G +V+ Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVI 403 Query: 151 SGGMDAQLKIW 161 +G D +IW Sbjct: 404 TGSKDNTCRIW 414 Score = 38.9 bits (89), Expect = 0.008 Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 3/97 (3%) Query: 117 KIWQASNGE--LRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKG 174 K+ Q SN L +VL+ H+ + SG ++G D K+W + T +G Sbjct: 73 KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132 Query: 175 HKGGILDTAIVD-RGRNVVSASRDGTARLWDCGRSAC 210 H+ + A + G + + S D T +LW C Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 169 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 83.6 bits (205), Expect = 3e-16 Identities = 42/126 (33%), Positives = 60/126 (47%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I+ + SS VS+S D T+K+W +G+ + L+GH V CC F P +++ Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D +KIW + C+ T H + G +VS S DG R+WD C Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC 201 Query: 211 LGVLAD 216 L L D Sbjct: 202 LKTLVD 207 Score = 68.9 bits (167), Expect = 7e-12 Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 1/122 (0%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H+ + C + + L +S S D T+KIW+ G+ + L H V+ F SG +++ Sbjct: 124 HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIV 183 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILD-TAIVDRGRNVVSASRDGTARLWDCGRSA 209 SG D +IW A C+ T + G+ +++A+ D T +LWD R Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243 Query: 210 CL 211 CL Sbjct: 244 CL 245 Score = 67.8 bits (164), Expect = 2e-11 Identities = 37/147 (25%), Positives = 65/147 (44%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT++++ + S G SSS D + IW A +G+ + L GH +++ + ++ Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S D LK+W C+ T KGH + ++S S D T ++W+ C Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159 Query: 211 LGVLADCGSSINGVAVGAADNSINLGS 237 L L+ ++ V + + I GS Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGS 186 Score = 64.7 bits (156), Expect = 1e-10 Identities = 61/224 (27%), Positives = 91/224 (40%), Gaps = 19/224 (8%) Query: 102 SRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIW 161 ++ L +SSS + + ++ + N L+ L GH V+ +F P+G + S D + IW Sbjct: 9 AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68 Query: 162 SAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI 221 A D T GH I D A +VSAS D T +LWD CL L + + Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128 Query: 222 NGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSD 281 N I GS ++ EV T K L+ L S + + Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKT----------GKCLKTLSAHSDP-----VSAV 173 Query: 282 AFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPV 325 FNC SG L+++G+ DG D S + ++ PV Sbjct: 174 HFNC----SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213 Score = 63.9 bits (154), Expect = 2e-10 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149 H+ ++ + + G L VS S DG +IW A++G+ L+ +++ V+ +F P+G + Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204 L+ +D LK+W C+ T+ GHK I V G+ +VS S D +W+ Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283 Score = 42.7 bits (99), Expect = 6e-04 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 5/114 (4%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151 ++ + S G ++++ D T+K+W S G + GH + C F G ++S Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272 Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW 203 G D + IW+ + V +GH ++ A + SA+ D T +LW Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 79.7 bits (195), Expect = 4e-15 Identities = 44/154 (28%), Positives = 68/154 (44%), Gaps = 9/154 (5%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + S G VS D ++W + + R+ GH+ DVNC RF P+ V Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 +G D +++W + +CV F GHKG I GR + + + DG LWD G Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703 Query: 211 LGVLADCGSSING---------VAVGAADNSINL 235 +G L ++ +A G+ DN++ L Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737 Score = 62.8 bits (151), Expect = 5e-10 Identities = 30/114 (26%), Positives = 46/114 (40%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + C + S D T+++W NG R+ GH ++ F P+G + Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 +G D ++ +W V KGH + G + S S D T RLWD Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 59.3 bits (142), Expect = 6e-09 Identities = 46/183 (25%), Positives = 71/183 (38%), Gaps = 40/183 (21%) Query: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELR------------------------- 127 + +T +D++ L D T+++W + +LR Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDE 530 Query: 128 ------RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181 ++L GH V F P +LS D +++WS + +C+V +KGH + D Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590 Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACL----GVLADCG-----SSINGVAVGAADNS 232 T G VS D ARLW L G LAD + N VA G+AD + Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650 Query: 233 INL 235 + L Sbjct: 651 VRL 653 Score = 44.7 bits (104), Expect = 1e-04 Identities = 23/73 (31%), Positives = 35/73 (47%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I L S G + +TDG + +W +G + L+GH V RF G ++ Sbjct: 668 HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727 Query: 151 SGGMDAQLKIWSA 163 SG MD +++W A Sbjct: 728 SGSMDNTVRLWDA 740 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 78.2 bits (191), Expect = 1e-14 Identities = 36/104 (34%), Positives = 55/104 (52%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDAS 167 VS+S D T+K+W G+ R L+GH V F SG ++ S D +K+W + Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 183 Query: 168 CVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACL 211 C+ T GH + AI+ G ++VSASRD T ++W+ C+ Sbjct: 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV 227 Score = 75.1 bits (183), Expect = 1e-13 Identities = 47/191 (24%), Positives = 79/191 (41%), Gaps = 1/191 (0%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT S+ + G L S S D T+K+W E R + GH +V+ P+G ++ Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV 208 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S D +K+W + CV TF GH+ + G + S S D T R+W C Sbjct: 209 SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC 268 Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270 L + + ++ A ++S + S ++ G LL DK ++ + + Sbjct: 269 KAELREHEHVVECIS-WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST 327 Query: 271 RQLVFLFIGSD 281 + +G D Sbjct: 328 GMCLMTLVGHD 338 Score = 56.6 bits (135), Expect = 4e-08 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 20/144 (13%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPS----- 145 H + + + + G L S S D T+++W + E + L H V C + P Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292 Query: 146 ---------------GLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRN 190 G +LSG D +K+W C++T GH + G+ Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352 Query: 191 VVSASRDGTARLWDCGRSACLGVL 214 ++S + D T R+WD C+ L Sbjct: 353 ILSCADDKTLRVWDYKNKRCMKTL 376 Score = 54.3 bits (129), Expect = 2e-07 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 1/125 (0%) Query: 82 APYTTFSRIHTKSITCLDISSRGG-LGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCC 140 AP +++S I + + S + G +S S D T+K+W S G L GH V Sbjct: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV 344 Query: 141 RFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTA 200 F G +LS D L++W ++ C+ T H+ + VV+ S D T Sbjct: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404 Query: 201 RLWDC 205 ++W+C Sbjct: 405 KVWEC 409 Score = 52.4 bits (124), Expect = 7e-07 Identities = 29/97 (29%), Positives = 44/97 (45%) Query: 130 LEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGR 189 L GH V F P V++S DA +K+W E T KGH + D + G+ Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163 Query: 190 NVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV 226 + S S D T +LWD C+ + +++ VA+ Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI 200 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 77.4 bits (189), Expect = 2e-14 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 ITCL G VS S D T+K+W A G+ R L GH V + + +++SG Sbjct: 266 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 321 Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 D LK+W+AE C+ T GH + + + + VVS SRD T R+WD CL VL Sbjct: 322 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 379 Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239 +++ V GA D + + PE Sbjct: 380 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 411 Score = 76.6 bits (187), Expect = 3e-14 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++ C+ + + VS S D T+++W G+ VL GHV V C ++ G V+ Sbjct: 342 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 397 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D +K+W E +C+ T +GH + G +VVS S D + R+WD C Sbjct: 398 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 455 Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235 + L S +G+ + G AD+++ + Sbjct: 456 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 487 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%) Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162 R + +S STD T+K+W A GE L GH V C V+SG DA L++W Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 369 Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221 E C+ GH + + GR VVS + D ++WD CL L + + Sbjct: 370 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427 Query: 222 ----NGVAV--GAADNSINLGSPE 239 +G+ V G+ D SI + E Sbjct: 428 SLQFDGIHVVSGSLDTSIRVWDVE 451 Score = 62.8 bits (151), Expect = 5e-10 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++ C+ R VS + D +K+W L+GH V +F G+ V+ Sbjct: 382 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 437 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG +D +++W E +C+ T GH+ L + + + +VS + D T ++WD C Sbjct: 438 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 495 Query: 211 LGVL 214 L L Sbjct: 496 LQTL 499 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181 GEL+ +VL+GH V C F G ++SG D LK+WSA C+ T GH GG+ Sbjct: 250 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 308 Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 + + R ++S S D T ++W+ C+ L Sbjct: 309 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 339 Score = 51.2 bits (121), Expect = 2e-06 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162 VS S D ++++W G L GH + SG+ +++SG D+ +KIW Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 489 Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + C+ T +G H+ + T + V+++S DGT +LWD Sbjct: 490 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 532 Score = 33.1 bits (74), Expect = 0.44 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130 H ++TCL + ++SS DGT+K+W GE R L Sbjct: 505 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 77.4 bits (189), Expect = 2e-14 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 ITCL G VS S D T+K+W A G+ R L GH V + + +++SG Sbjct: 384 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 439 Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 D LK+W+AE C+ T GH + + + + VVS SRD T R+WD CL VL Sbjct: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 497 Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239 +++ V GA D + + PE Sbjct: 498 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 529 Score = 76.6 bits (187), Expect = 3e-14 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++ C+ + + VS S D T+++W G+ VL GHV V C ++ G V+ Sbjct: 460 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 515 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D +K+W E +C+ T +GH + G +VVS S D + R+WD C Sbjct: 516 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 573 Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235 + L S +G+ + G AD+++ + Sbjct: 574 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 605 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%) Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162 R + +S STD T+K+W A GE L GH V C V+SG DA L++W Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487 Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221 E C+ GH + + GR VVS + D ++WD CL L + + Sbjct: 488 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545 Query: 222 ----NGVAV--GAADNSINLGSPE 239 +G+ V G+ D SI + E Sbjct: 546 SLQFDGIHVVSGSLDTSIRVWDVE 569 Score = 62.8 bits (151), Expect = 5e-10 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++ C+ R VS + D +K+W L+GH V +F G+ V+ Sbjct: 500 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 555 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG +D +++W E +C+ T GH+ L + + + +VS + D T ++WD C Sbjct: 556 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 613 Query: 211 LGVL 214 L L Sbjct: 614 LQTL 617 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181 GEL+ +VL+GH V C F G ++SG D LK+WSA C+ T GH GG+ Sbjct: 368 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 426 Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 + + R ++S S D T ++W+ C+ L Sbjct: 427 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 457 Score = 51.2 bits (121), Expect = 2e-06 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162 VS S D ++++W G L GH + SG+ +++SG D+ +KIW Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 607 Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + C+ T +G H+ + T + V+++S DGT +LWD Sbjct: 608 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 650 Score = 33.1 bits (74), Expect = 0.44 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130 H ++TCL + ++SS DGT+K+W GE R L Sbjct: 623 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 77.4 bits (189), Expect = 2e-14 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 ITCL G VS S D T+K+W A G+ R L GH V + + +++SG Sbjct: 304 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 359 Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 D LK+W+AE C+ T GH + + + + VVS SRD T R+WD CL VL Sbjct: 360 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 417 Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239 +++ V GA D + + PE Sbjct: 418 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 449 Score = 76.6 bits (187), Expect = 3e-14 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++ C+ + + VS S D T+++W G+ VL GHV V C ++ G V+ Sbjct: 380 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 435 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D +K+W E +C+ T +GH + G +VVS S D + R+WD C Sbjct: 436 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 493 Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235 + L S +G+ + G AD+++ + Sbjct: 494 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 525 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%) Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162 R + +S STD T+K+W A GE L GH V C V+SG DA L++W Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 407 Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221 E C+ GH + + GR VVS + D ++WD CL L + + Sbjct: 408 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465 Query: 222 ----NGVAV--GAADNSINLGSPE 239 +G+ V G+ D SI + E Sbjct: 466 SLQFDGIHVVSGSLDTSIRVWDVE 489 Score = 62.8 bits (151), Expect = 5e-10 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++ C+ R VS + D +K+W L+GH V +F G+ V+ Sbjct: 420 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 475 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG +D +++W E +C+ T GH+ L + + + +VS + D T ++WD C Sbjct: 476 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 533 Query: 211 LGVL 214 L L Sbjct: 534 LQTL 537 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181 GEL+ +VL+GH V C F G ++SG D LK+WSA C+ T GH GG+ Sbjct: 288 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 346 Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214 + + R ++S S D T ++W+ C+ L Sbjct: 347 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 377 Score = 51.2 bits (121), Expect = 2e-06 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162 VS S D ++++W G L GH + SG+ +++SG D+ +KIW Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 527 Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + C+ T +G H+ + T + V+++S DGT +LWD Sbjct: 528 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 570 Score = 33.1 bits (74), Expect = 0.44 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130 H ++TCL + ++SS DGT+K+W GE R L Sbjct: 543 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 75.9 bits (185), Expect = 6e-14 Identities = 37/114 (32%), Positives = 57/114 (50%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + LDIS S S D T ++W R+ GH+ DV+C +F P+ + Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 +G D +++WSA+ + V F GH+G +L A G+ + SA D +LWD Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496 Score = 71.6 bits (174), Expect = 1e-12 Identities = 38/145 (26%), Positives = 59/145 (40%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + C+ + STD T+++W A G R+ GH V F P+G + Sbjct: 425 HLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLA 484 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S G D +LK+W + +GH I + SAS D + R+WD + C Sbjct: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544 Query: 211 LGVLADCGSSINGVAVGAADNSINL 235 S + GV G N +++ Sbjct: 545 SAPADGSSSELVGVYTGQMSNVLSV 569 Score = 54.7 bits (130), Expect = 1e-07 Identities = 55/210 (26%), Positives = 83/210 (39%), Gaps = 23/210 (10%) Query: 124 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTA 183 G ++L GH V RF +LS D ++ W + V ++GH + D Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391 Query: 184 IVDRGRNVVSASRDGTARLWDCGRSACLGVLA------DC---GSSINGVAVGAADNSIN 234 I S S D TARLW R+ L + A DC + N +A G+ D ++ Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451 Query: 235 LGSPEQMPSER------------EVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SD 281 L S +Q S R K L A ED++L+ L S L G +D Sbjct: 452 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511 Query: 282 AFNCCTFL-SGFLLLAGTQDGNIYQLDVRS 310 TF L+ + + D ++ D+R+ Sbjct: 512 NITSLTFSPDSGLIASASMDNSVRVWDIRN 541 Score = 34.3 bits (77), Expect = 0.20 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 11/75 (14%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIW-----------QASNGELRRVLEGHVFDV 137 R HT +IT L S GL S+S D ++++W S+ EL V G + +V Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566 Query: 138 NCCRFFPSGLVVLSG 152 +F L++++G Sbjct: 567 LSVQFMACNLLLVTG 581 >gi|102470001 PQQ repeat and WD repeat domain containing [Homo sapiens] Length = 472 Score = 74.3 bits (181), Expect = 2e-13 Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%) Query: 82 APYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRR------VLEGHVF 135 A T ++ H+ +I+ + G +SS D +KIW GE R +++GH Sbjct: 263 ATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEG 322 Query: 136 DVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS 195 V+ C F ++SGG D + IW + ++ KGH ++D AI + + ++SAS Sbjct: 323 SVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS 382 Query: 196 RDGTARLWD 204 +D T RLW+ Sbjct: 383 KDRTMRLWN 391 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 11/123 (8%) Query: 91 HTKSIT--CLDISSRGGLGVSSSTDGTMKIWQA-SNGELRRVLEGHVFDVNCCRFFPSGL 147 HT+SIT C D S+ VS D +KIW S L + + H ++ C F SG Sbjct: 229 HTRSITSCCFDPDSQRVASVS--LDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH 286 Query: 148 VVLSGGMDAQLKIWSAED------ASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201 + + D LKIW+ +CV +GH+G + ++S D T Sbjct: 287 FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVA 346 Query: 202 LWD 204 +WD Sbjct: 347 IWD 349 Score = 50.4 bits (119), Expect = 3e-06 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 1/78 (1%) Query: 128 RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGH-KGGILDTAIVD 186 ++L GH V+ C F +LSG D +K+W D S V F+ K +++ +I Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155 Query: 187 RGRNVVSASRDGTARLWD 204 V++AS D T R WD Sbjct: 156 DSSRVIAASYDKTVRAWD 173 Score = 43.9 bits (102), Expect = 3e-04 Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 3/106 (2%) Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG-GMDAQLKIWSAEDA 166 +++S D T++ W G+L + F V+ C+F P G V+SG +D + I AE+ Sbjct: 161 IAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIMDAENI 219 Query: 167 SCVVTFKGHKGGILDTAIVD-RGRNVVSASRDGTARLWDCGRSACL 211 + V K H + + D + V S S D ++WD A L Sbjct: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265 Score = 35.8 bits (81), Expect = 0.068 Identities = 21/94 (22%), Positives = 39/94 (41%), Gaps = 5/94 (5%) Query: 129 VLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTF-KGHKGGILDTAIVDR 187 + + H + C F P V S +D +KIW + ++T K H I + Sbjct: 225 IKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFS 284 Query: 188 GRNVVSASRDGTARLWDCGRSACLGVLADCGSSI 221 G + ++S D ++W + G +CG+ + Sbjct: 285 GHFLCTSSWDKNLKIW----NVHTGEFRNCGACV 314 >gi|157266266 WD repeat domain 86 [Homo sapiens] Length = 376 Score = 73.6 bits (179), Expect = 3e-13 Identities = 60/225 (26%), Positives = 90/225 (40%), Gaps = 29/225 (12%) Query: 94 SITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGG 153 S C + ++ GGL V+ STDGT K+WQ ++G + L GH V C G +G Sbjct: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212 Query: 154 MDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGV 213 DA ++ W + F+ H+G ++ +V+ R V S S D T + W Sbjct: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVN--RLVYSGSADRTVKCW---------- 260 Query: 214 LADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQL 273 LAD G + + S + A L D + QS +L Sbjct: 261 LADTGECVRTFTAHRRNVS-------------ALKYHAGTLFTGSGDACARAFDAQSGEL 307 Query: 274 VFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVR----SPRAP 314 +F G C + G +L + DG + DVR +PR P Sbjct: 308 RRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPP 352 Score = 60.8 bits (146), Expect = 2e-09 Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 4/116 (3%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 R HT ++ CL + + G + STD T++ W +GE RV H V C + Sbjct: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRL 247 Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 V SG D +K W A+ CV TF H+ + +A+ + + S D AR +D Sbjct: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNV--SALKYHAGTLFTGSGDACARAFD 301 Score = 53.9 bits (128), Expect = 2e-07 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 12/117 (10%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I L +S G ++ S DGT ++W ++G+ +L+GH V C+ Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDR----GRNVVSASRDGTARLW 203 S D ++ W C+ ++GH T+IV+R + S+S D TAR+W Sbjct: 74 SA--DCTIRRWDVLTGQCLQVYRGH------TSIVNRILVANNQLFSSSYDRTARVW 122 Score = 48.5 bits (114), Expect = 1e-05 Identities = 29/103 (28%), Positives = 41/103 (39%), Gaps = 2/103 (1%) Query: 124 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTA 183 G RV H +N P G +L+G D ++WS D C +GH+ + Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64 Query: 184 IVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV 226 + D + S D T R WD CL V S +N + V Sbjct: 65 LEDEA--AFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV 105 Score = 46.6 bits (109), Expect = 4e-05 Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 16/114 (14%) Query: 111 STDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170 S D T++ W G+ +V GH VN R + + S D ++WS + Sbjct: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSR 131 Query: 171 TFKGHKGGILDTAI--------------VDRGRNVVSASRDGTARLWDCGRSAC 210 F+GH+ +L A G +V+ S DGTA++W C Sbjct: 132 EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185 >gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo sapiens] Length = 340 Score = 72.8 bits (177), Expect = 5e-13 Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 21/225 (9%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N + R L GH ++CCRF ++ S G D +W E V F GH G ++ Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSL 190 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242 ++ GR VS + D + +LWD S C S IN VA + GS + Sbjct: 191 SLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATC 250 Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302 ++ + ++L+ + ++ + I S AF+ SG LLLAG D N Sbjct: 251 RLFDLRADQELLMYSHDN-------------IICGITSVAFS----RSGRLLLAGYDDFN 293 Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346 D ++ RA V H + L + DG + G F+ Sbjct: 294 CNIWDAMKGDRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336 Score = 65.5 bits (158), Expect = 8e-11 Identities = 49/182 (26%), Positives = 75/182 (41%), Gaps = 7/182 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++C + ++SS D T +W G+ GH DV P G + Sbjct: 142 HTGYLSCCRFLDDNQI-ITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG DA +K+W D+ C TF GH+ I A G + S D T RL+D Sbjct: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260 Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266 L + + CG I VA + + G + + + + +LA D ++ CL Sbjct: 261 LLMYSHDNIICG--ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCL 318 Query: 267 GL 268 G+ Sbjct: 319 GV 320 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 2/149 (1%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H+ + L ++ G VS + D ++K+W + R+ GH D+N FFP+G Sbjct: 183 HSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFT 242 Query: 151 SGGMDAQLKIWS--AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208 +G DA +++ A+ + + GI A GR +++ D +WD + Sbjct: 243 TGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKG 302 Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGS 237 GVLA + ++ + V ++ GS Sbjct: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 Score = 43.5 bits (101), Expect = 3e-04 Identities = 24/68 (35%), Positives = 33/68 (48%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 IT + S G L ++ D IW A G+ VL GH V+C G+ V +G Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 Query: 155 DAQLKIWS 162 D+ LKIW+ Sbjct: 333 DSFLKIWN 340 Score = 29.6 bits (65), Expect = 4.9 Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 19/175 (10%) Query: 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAAD 230 T +GH I R +VSAS+DG +WD + + + S + A + Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 Query: 231 NSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLS 290 N + G + + S + T + ++RE L + +CC FL Sbjct: 110 NFVACGGLDNICSIYSLKTREGNVRVSRE----------------LPGHTGYLSCCRFLD 153 Query: 291 GFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDG--FIASQGDGS 343 ++ + D D+ + + V SG V+SL DG F++ D S Sbjct: 154 DNQIITSSGDTTCALWDIETGQQTVGFAGHSG-DVMSLSLAPDGRTFVSGACDAS 207 >gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo sapiens] Length = 504 Score = 70.9 bits (172), Expect = 2e-12 Identities = 40/121 (33%), Positives = 63/121 (52%), Gaps = 8/121 (6%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL-----EGHVFDVNCCRFF 143 R H ++T L + + G +SSS D + W S+ + RVL E + C +F Sbjct: 303 RAHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFH 359 Query: 144 PSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 P GL+ +G MD+Q+KIW ++ + V F GH G I A + G + +A+ D + +LW Sbjct: 360 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419 Query: 204 D 204 D Sbjct: 420 D 420 Score = 52.4 bits (124), Expect = 7e-07 Identities = 47/181 (25%), Positives = 84/181 (46%), Gaps = 11/181 (6%) Query: 28 PPGKPSLYGSLTCQGIG-LDGI-PEVTAS--EGFTVNEINKKSIHISCPKENASSKFLAP 83 P +PS+ G+ +G L G+ PE+ + TV +K + P+E + L+ Sbjct: 147 PSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSK 206 Query: 84 YTTFSR---IHTKSIT---CLDIS-SRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFD 136 Y + +H+ SI LD+ S ++ D + ++ S+ ++ L+GH Sbjct: 207 YRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK 266 Query: 137 VNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASR 196 V F PS +V S DA ++IWS +ASCV + H+ + ++ G ++S+S Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 326 Query: 197 D 197 D Sbjct: 327 D 327 Score = 45.4 bits (106), Expect = 9e-05 Identities = 43/197 (21%), Positives = 78/197 (39%), Gaps = 21/197 (10%) Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208 +L+GG D + ++ + T KGH + V SAS D T R+W + Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296 Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGL 268 +C+ V+ S++ G+++ A + + S +Q + ++ T +L D+ C Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT--GRVLTKVTDETSGC--- 351 Query: 269 QSRQLVFLFIGSDAFNCCTF-LSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLS 327 + C F G + GT D I D++ R V P+ S Sbjct: 352 -------------SLTCAQFHPDGLIFGTGTMDSQIKIWDLKE-RTNVANFPGHSGPITS 397 Query: 328 LLSVRDG-FIASQGDGS 343 + +G ++A+ D S Sbjct: 398 IAFSENGYYLATAADDS 414 Score = 33.1 bits (74), Expect = 0.44 Identities = 25/114 (21%), Positives = 49/114 (42%), Gaps = 3/114 (2%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLE-GHVFDVNCCRFFPSGLVV 149 H+ IT + S G +++ D ++K+W + + L+ + F+V F SG + Sbjct: 391 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL 450 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 GG D Q I+ + + ++ F H G A + + S D + + + Sbjct: 451 ALGGTDVQ--IYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 >gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo sapiens] Length = 542 Score = 70.9 bits (172), Expect = 2e-12 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147 H +++ L S+ GL V+ S D ++ +W A++ LRRVL GH VN F + Sbjct: 319 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 376 Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207 V SG D +K+WS V T GHK GI + R R VVS S D T RLWD Sbjct: 377 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 432 Query: 208 SACLGVL 214 ACL VL Sbjct: 433 GACLRVL 439 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + I CL R L VS S+D T+++W G RVLEGH V C RF ++ Sbjct: 402 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 457 Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201 SG D ++K+W + A C+ T H G + + ++S+S D T Sbjct: 458 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 515 Query: 202 LWD 204 +WD Sbjct: 516 IWD 518 Score = 47.0 bits (110), Expect = 3e-05 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 ++K + CL +S D ++KIW ++ E +VL GH V C ++ V++ Sbjct: 239 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 294 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 +G D+ +++W + T H +L +V+ S+D + +WD + Sbjct: 295 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 352 Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251 + VL +++N V + D +I + S R + Sbjct: 353 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 412 Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310 ++++ D ++ ++ + + G + C +++G DG I D+++ Sbjct: 413 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 472 Query: 311 ---PRAPVQVI 318 PRAP + Sbjct: 473 ALDPRAPASTL 483 >gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] Length = 631 Score = 70.9 bits (172), Expect = 2e-12 Identities = 38/114 (33%), Positives = 49/114 (42%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H++++ S G SSS D T KIW ++ R L GH VN FFP +L Sbjct: 435 HSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL 494 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + D L IW A C + GH I D RG + S G +LWD Sbjct: 495 TSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548 Score = 64.3 bits (155), Expect = 2e-10 Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 1/174 (0%) Query: 68 HISCPKENAS-SKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGEL 126 +++ KE+ S +KF R+H ++C+ + + VS D K+ + Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNV 386 Query: 127 RRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVD 186 GH ++ C F PSG + + D +K+W C++TF+GH + Sbjct: 387 LLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHS 446 Query: 187 RGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240 G V S+S D T+++WD C L S+N + N++ S ++ Sbjct: 447 CGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADK 500 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/132 (27%), Positives = 50/132 (37%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++ G +SS D T+K+W G+ EGH V C + G V Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 S +D KIW C T GH + ++++S D T +WD C Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512 Query: 211 LGVLADCGSSIN 222 L SIN Sbjct: 513 EQSLYGHMHSIN 524 Score = 33.5 bits (75), Expect = 0.34 Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 1/65 (1%) Query: 98 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 157 ++ S G + +S +G + + +GE+ +++ GH + + F G ++ SGG D Sbjct: 568 VNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGT 626 Query: 158 LKIWS 162 ++ WS Sbjct: 627 VRTWS 631 >gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo sapiens] Length = 508 Score = 70.9 bits (172), Expect = 2e-12 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147 H +++ L S+ GL V+ S D ++ +W A++ LRRVL GH VN F + Sbjct: 285 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342 Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207 V SG D +K+WS V T GHK GI + R R VVS S D T RLWD Sbjct: 343 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 398 Query: 208 SACLGVL 214 ACL VL Sbjct: 399 GACLRVL 405 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + I CL R L VS S+D T+++W G RVLEGH V C RF ++ Sbjct: 368 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 423 Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201 SG D ++K+W + A C+ T H G + + ++S+S D T Sbjct: 424 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 481 Query: 202 LWD 204 +WD Sbjct: 482 IWD 484 Score = 47.0 bits (110), Expect = 3e-05 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 ++K + CL +S D ++KIW ++ E +VL GH V C ++ V++ Sbjct: 205 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 260 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 +G D+ +++W + T H +L +V+ S+D + +WD + Sbjct: 261 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 318 Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251 + VL +++N V + D +I + S R + Sbjct: 319 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378 Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310 ++++ D ++ ++ + + G + C +++G DG I D+++ Sbjct: 379 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 438 Query: 311 ---PRAPVQVI 318 PRAP + Sbjct: 439 ALDPRAPASTL 449 >gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo sapiens] Length = 529 Score = 70.9 bits (172), Expect = 2e-12 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147 H +++ L S+ GL V+ S D ++ +W A++ LRRVL GH VN F + Sbjct: 306 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363 Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207 V SG D +K+WS V T GHK GI + R R VVS S D T RLWD Sbjct: 364 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 419 Query: 208 SACLGVL 214 ACL VL Sbjct: 420 GACLRVL 426 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + I CL R L VS S+D T+++W G RVLEGH V C RF ++ Sbjct: 389 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 444 Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201 SG D ++K+W + A C+ T H G + + ++S+S D T Sbjct: 445 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 502 Query: 202 LWD 204 +WD Sbjct: 503 IWD 505 Score = 47.0 bits (110), Expect = 3e-05 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 ++K + CL +S D ++KIW ++ E +VL GH V C ++ V++ Sbjct: 226 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 281 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 +G D+ +++W + T H +L +V+ S+D + +WD + Sbjct: 282 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 339 Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251 + VL +++N V + D +I + S R + Sbjct: 340 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399 Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310 ++++ D ++ ++ + + G + C +++G DG I D+++ Sbjct: 400 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 459 Query: 311 ---PRAPVQVI 318 PRAP + Sbjct: 460 ALDPRAPASTL 470 >gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo sapiens] Length = 340 Score = 69.7 bits (169), Expect = 4e-12 Identities = 62/225 (27%), Positives = 89/225 (39%), Gaps = 21/225 (9%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N + R L GH ++CCRF +V S G D +W E TF GH G ++ Sbjct: 132 NVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSL 190 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242 ++ R VS + D +A+LWD C S IN + N+ GS + Sbjct: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD--- 247 Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302 L R D++L S + I S +F+ SG LLLAG D N Sbjct: 248 -------ATCRLFDLRADQELM---TYSHDNIICGITSVSFS----KSGRLLLAGYDDFN 293 Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346 D +++ RA V H + L + DG + G F+ Sbjct: 294 CNVWDALKADRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/182 (25%), Positives = 71/182 (39%), Gaps = 7/182 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++C + V+SS D T +W G+ GH DV P + + Sbjct: 142 HTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFV 200 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG DA K+W + C TF GH+ I G + S D T RL+D Sbjct: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260 Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266 L + CG I V+ + + G + + + + +LA D ++ CL Sbjct: 261 LMTYSHDNIICG--ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 318 Query: 267 GL 268 G+ Sbjct: 319 GV 320 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/155 (25%), Positives = 70/155 (45%), Gaps = 3/155 (1%) Query: 85 TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144 TTF+ HT + L ++ L VS + D + K+W G R+ GH D+N FFP Sbjct: 178 TTFTG-HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP 236 Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHK--GGILDTAIVDRGRNVVSASRDGTARL 202 +G +G DA +++ ++T+ GI + GR +++ D + Sbjct: 237 NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296 Query: 203 WDCGRSACLGVLADCGSSINGVAVGAADNSINLGS 237 WD ++ GVLA + ++ + V ++ GS Sbjct: 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 Score = 41.6 bits (96), Expect = 0.001 Identities = 22/68 (32%), Positives = 32/68 (47%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 IT + S G L ++ D +W A + VL GH V+C G+ V +G Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 Query: 155 DAQLKIWS 162 D+ LKIW+ Sbjct: 333 DSFLKIWN 340 >gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo sapiens] Length = 340 Score = 69.3 bits (168), Expect = 6e-12 Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 21/225 (9%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N + R L GH ++CCRF +V S G D +W E A TF GH G ++ Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSL 190 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242 ++ R VS + D +++LWD C S IN V+ + GS + Sbjct: 191 SLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250 Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302 ++ + ++LL + ++ + I S AF+ SG LLLAG D N Sbjct: 251 RLFDLRADQELLLYSHDN-------------IICGITSVAFS----KSGRLLLAGYDDFN 293 Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346 D ++ RA V H + L + DG + G F+ Sbjct: 294 CNVWDTLKGDRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336 Score = 59.7 bits (143), Expect = 4e-09 Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 3/155 (1%) Query: 85 TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144 TTF+ H+ + L +S VS + D + K+W +G R+ GHV D+N FFP Sbjct: 178 TTFTG-HSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFP 236 Query: 145 SGLVVLSGGMDAQLKIWS--AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202 +G +G DA +++ A+ + + GI A GR +++ D + Sbjct: 237 NGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNV 296 Query: 203 WDCGRSACLGVLADCGSSINGVAVGAADNSINLGS 237 WD + GVLA + ++ + V ++ GS Sbjct: 297 WDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 Score = 56.6 bits (135), Expect = 4e-08 Identities = 46/182 (25%), Positives = 70/182 (38%), Gaps = 7/182 (3%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++C + V+SS D T +W + GH DV P + Sbjct: 142 HTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFV 200 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG DA K+W D C +F GH I + G + S D T RL+D Sbjct: 201 SGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQE 260 Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266 L + + CG I VA + + G + + + + +LA D ++ CL Sbjct: 261 LLLYSHDNIICG--ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCL 318 Query: 267 GL 268 G+ Sbjct: 319 GV 320 Score = 40.4 bits (93), Expect = 0.003 Identities = 21/68 (30%), Positives = 32/68 (47%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 IT + S G L ++ D +W G+ VL GH V+C G+ V +G Sbjct: 273 ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 Query: 155 DAQLKIWS 162 D+ L+IW+ Sbjct: 333 DSFLRIWN 340 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 68.9 bits (167), Expect = 7e-12 Identities = 38/155 (24%), Positives = 69/155 (44%) Query: 85 TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144 +T R HT ++ + S G V++S D T+K+W + L H+ V C +F P Sbjct: 58 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117 Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 G +++S D +K+W CV ++ H G + G + +A D T ++WD Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177 Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239 L +++NG++ + N + S + Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 212 Score = 61.2 bits (147), Expect = 2e-09 Identities = 50/210 (23%), Positives = 81/210 (38%), Gaps = 21/210 (10%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++TC++ S G L S S D T++IW + V H V F G + Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 + D +K+W+ + + H + GR +VSAS D T +LWD C Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141 Query: 211 LGVLADCGSSI-------NGVAVGAA--DNSINLGSPE--------QMPSEREVG----T 249 + + G + +G + AA DN++ + Q+ S G Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 201 Query: 250 EAKMLLLAREDKKLQCLGLQSRQLVFLFIG 279 L+ A D L+ L L +L++ G Sbjct: 202 SGNYLITASSDSTLKILDLMEGRLLYTLHG 231 Score = 52.0 bits (123), Expect = 9e-07 Identities = 46/204 (22%), Positives = 76/204 (37%), Gaps = 27/204 (13%) Query: 113 DGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTF 172 D + +W GH V C F PSG ++ SG D ++IW F Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61 Query: 173 KGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNS 232 + H + G++ V+AS D T ++W R L L+ IN V Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLS---QHINWVRCA----- 113 Query: 233 INLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFL--- 289 + + ++++ A +DK ++ SR+ V + F T++ Sbjct: 114 -------------KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFH 158 Query: 290 -SGFLLLAGTQDGNIYQLDVRSPR 312 SG + A D + DVR+ R Sbjct: 159 PSGTCIAAAGMDNTVKVWDVRTHR 182 Score = 50.8 bits (120), Expect = 2e-06 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%) Query: 40 CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96 C DG V+AS+ TV +K S +H C H +T Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 153 Query: 97 CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156 +D G ++ D T+K+W L + + H VN F PSG +++ D+ Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213 Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 LKI + + T GH+G A G S D +W Sbjct: 214 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260 Score = 43.1 bits (100), Expect = 4e-04 Identities = 21/75 (28%), Positives = 35/75 (46%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 ++H+ ++ L G +++S+D T+KI G L L GH F +G Sbjct: 188 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247 Query: 149 VLSGGMDAQLKIWSA 163 SGG D Q+ +W + Sbjct: 248 FASGGSDEQVMVWKS 262 Score = 36.2 bits (82), Expect = 0.052 Identities = 17/50 (34%), Positives = 23/50 (46%) Query: 154 MDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 MD+ L +W + S F GHK + G + S SRD T R+W Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 68.9 bits (167), Expect = 7e-12 Identities = 38/155 (24%), Positives = 69/155 (44%) Query: 85 TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144 +T R HT ++ + S G V++S D T+K+W + L H+ V C +F P Sbjct: 96 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155 Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 G +++S D +K+W CV ++ H G + G + +A D T ++WD Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215 Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239 L +++NG++ + N + S + Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 250 Score = 63.5 bits (153), Expect = 3e-10 Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 27/226 (11%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++TC+D S S S D + +W GH V C F PSG ++ Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D ++IW F+ H + G++ V+AS D T ++W R Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137 Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270 L L+ IN V + + ++++ A +DK ++ S Sbjct: 138 LFSLS---QHINWVRCA------------------KFSPDGRLIVSASDDKTVKLWDKSS 176 Query: 271 RQLVFLFIGSDAFNCCTFL----SGFLLLAGTQDGNIYQLDVRSPR 312 R+ V + F T++ SG + A D + DVR+ R Sbjct: 177 RECVHSYCEHGGF--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/114 (28%), Positives = 51/114 (44%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + C S G L VS+S D T+K+W S+ E H V F PSG + Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 203 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + GMD +K+W + ++ H + + G +++AS D T ++ D Sbjct: 204 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257 Score = 50.8 bits (120), Expect = 2e-06 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%) Query: 40 CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96 C DG V+AS+ TV +K S +H C H +T Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 191 Query: 97 CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156 +D G ++ D T+K+W L + + H VN F PSG +++ D+ Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251 Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 LKI + + T GH+G A G S D +W Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 48.5 bits (114), Expect = 1e-05 Identities = 27/83 (32%), Positives = 37/83 (44%) Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180 A + L R +GH V C F + + SG MD+ L +W + S F GHK + Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65 Query: 181 DTAIVDRGRNVVSASRDGTARLW 203 G + S SRD T R+W Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88 Score = 43.1 bits (100), Expect = 4e-04 Identities = 21/75 (28%), Positives = 35/75 (46%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 ++H+ ++ L G +++S+D T+KI G L L GH F +G Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285 Query: 149 VLSGGMDAQLKIWSA 163 SGG D Q+ +W + Sbjct: 286 FASGGSDEQVMVWKS 300 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 68.9 bits (167), Expect = 7e-12 Identities = 38/155 (24%), Positives = 69/155 (44%) Query: 85 TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144 +T R HT ++ + S G V++S D T+K+W + L H+ V C +F P Sbjct: 96 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155 Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 G +++S D +K+W CV ++ H G + G + +A D T ++WD Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215 Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239 L +++NG++ + N + S + Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 250 Score = 63.5 bits (153), Expect = 3e-10 Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 27/226 (11%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++TC+D S S S D + +W GH V C F PSG ++ Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 SG D ++IW F+ H + G++ V+AS D T ++W R Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137 Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270 L L+ IN V + + ++++ A +DK ++ S Sbjct: 138 LFSLS---QHINWVRCA------------------KFSPDGRLIVSASDDKTVKLWDKSS 176 Query: 271 RQLVFLFIGSDAFNCCTFL----SGFLLLAGTQDGNIYQLDVRSPR 312 R+ V + F T++ SG + A D + DVR+ R Sbjct: 177 RECVHSYCEHGGF--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220 Score = 56.6 bits (135), Expect = 4e-08 Identities = 32/114 (28%), Positives = 51/114 (44%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + C S G L VS+S D T+K+W S+ E H V F PSG + Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 203 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + GMD +K+W + ++ H + + G +++AS D T ++ D Sbjct: 204 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257 Score = 50.8 bits (120), Expect = 2e-06 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%) Query: 40 CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96 C DG V+AS+ TV +K S +H C H +T Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 191 Query: 97 CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156 +D G ++ D T+K+W L + + H VN F PSG +++ D+ Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251 Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203 LKI + + T GH+G A G S D +W Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 48.5 bits (114), Expect = 1e-05 Identities = 27/83 (32%), Positives = 37/83 (44%) Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180 A + L R +GH V C F + + SG MD+ L +W + S F GHK + Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65 Query: 181 DTAIVDRGRNVVSASRDGTARLW 203 G + S SRD T R+W Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88 Score = 43.1 bits (100), Expect = 4e-04 Identities = 21/75 (28%), Positives = 35/75 (46%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 ++H+ ++ L G +++S+D T+KI G L L GH F +G Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285 Query: 149 VLSGGMDAQLKIWSA 163 SGG D Q+ +W + Sbjct: 286 FASGGSDEQVMVWKS 300 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 68.9 bits (167), Expect = 7e-12 Identities = 56/236 (23%), Positives = 95/236 (40%), Gaps = 4/236 (1%) Query: 44 GLDGIPEVTASEGFTVNEINKKSIHISCPKENASSK--FLAPYTTFSRI--HTKSITCLD 99 G P+ TA + N K+ + K K + P+ + I H + C+ Sbjct: 152 GASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIA 211 Query: 100 ISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLK 159 + V+ S D T+KIW ++G+L+ L GH+ V + S G D Q+K Sbjct: 212 VEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVK 271 Query: 160 IWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGS 219 W E + + GH + + +V+ SRD TAR+WD A + L+ + Sbjct: 272 CWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 331 Query: 220 SINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVF 275 ++ V AA+ I GS + ++ + L K ++ + L R F Sbjct: 332 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTF 387 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/151 (21%), Positives = 59/151 (39%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H ++ + +S+R S D +K W ++ R GH+ V P+ V++ Sbjct: 245 HISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLV 304 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210 + D+ +IW + V T GH + +++ S D T RLWD Sbjct: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364 Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQM 241 L + S+ V + + GSP+ + Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPDNI 395 Score = 49.7 bits (117), Expect = 5e-06 Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 2/114 (1%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++ + + ++ S D T+++W G+ R L H V P Sbjct: 329 HTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFA 388 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 SG D +K W D S + GH I++T V+ +VS + +GT LWD Sbjct: 389 SGSPD-NIKQWKFPDGSFIQNLSGHNA-IINTLTVNSDGVLVSGADNGTMHLWD 440 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 68.9 bits (167), Expect = 7e-12 Identities = 38/150 (25%), Positives = 68/150 (45%), Gaps = 1/150 (0%) Query: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152 K I + S G S + DG + I+ + G+L LEGH + F P ++++ Sbjct: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208 Query: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLG 212 D +KI+ + A+ T GH +L+ A + VS+S D + ++WD G C+ Sbjct: 209 SDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVH 268 Query: 213 VLADCGSSINGVAV-GAADNSINLGSPEQM 241 D + GV G +++G +++ Sbjct: 269 TFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298 Score = 56.2 bits (134), Expect = 5e-08 Identities = 33/115 (28%), Positives = 47/115 (40%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H I L S L V++S DG +KI+ + L L GH V F P + Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205 S D +K+W +CV TF H+ + G +VS D ++DC Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 40.8 bits (94), Expect = 0.002 Identities = 41/201 (20%), Positives = 70/201 (34%), Gaps = 42/201 (20%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEG------------------ 132 H + +DIS + SSS D +++W NG+ + ++ Sbjct: 63 HQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLA 122 Query: 133 ---HVFDVN---------------------CCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168 HV VN + P G + SG +D + I+ Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL 182 Query: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228 + T +GH I + +V+AS DG +++D + G L+ S + VA Sbjct: 183 LHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCP 242 Query: 229 ADNSINLGSPEQMPSEREVGT 249 D S ++ +VGT Sbjct: 243 DDTHFVSSSSDKSVKVWDVGT 263 Score = 31.2 bits (69), Expect = 1.7 Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 2/58 (3%) Query: 149 VLSGGMDAQLKIWSAEDASCVV--TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 V++G +D +K+W D + + +GH+ G++ I S+S D RLWD Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92 >gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo sapiens] Length = 340 Score = 68.6 bits (166), Expect = 1e-11 Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 17/187 (9%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT ++C + V+SS D T +W G+ + V GH D P + + Sbjct: 142 HTGYLSCCRFLDDNNI-VTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFI 200 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC----- 205 SG DA K+W + +C TF GH+ I G + + S D + RL+D Sbjct: 201 SGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQE 260 Query: 206 ----GRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDK 261 + + + S++G + A + N + M SER VG +L+ D Sbjct: 261 LICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSER-VG------ILSGHDN 313 Query: 262 KLQCLGL 268 ++ CLG+ Sbjct: 314 RVSCLGV 320 Score = 65.9 bits (159), Expect = 6e-11 Identities = 60/225 (26%), Positives = 89/225 (39%), Gaps = 21/225 (9%) Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182 N ++ R L H ++CCRF +V S G D +W E F GH G + Sbjct: 132 NVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSL 190 Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242 A+ +S + D +A+LWD C S IN + +I GS + Sbjct: 191 AVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDD--- 247 Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302 + L R D++L C S + + I S AF+ LSG LL AG D N Sbjct: 248 -------ASCRLFDLRADQELICF---SHESIICGITSVAFS----LSGRLLFAGYDDFN 293 Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346 D ++S R + H + L + + DG + G F+ Sbjct: 294 CNVWDSMKSERVGILSGHDNRVSCLGVTA--DGMAVATGSWDSFL 336 Score = 38.9 bits (89), Expect = 0.008 Identities = 21/68 (30%), Positives = 31/68 (45%) Query: 95 ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154 IT + S G L + D +W + E +L GH V+C G+ V +G Sbjct: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSW 332 Query: 155 DAQLKIWS 162 D+ LKIW+ Sbjct: 333 DSFLKIWN 340 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 68.2 bits (165), Expect = 1e-11 Identities = 37/114 (32%), Positives = 55/114 (48%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H + C+DIS G L + S D +KIW G+ + L H V +F P + Sbjct: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + G D ++K W A+ + T +GH I A+ G VVS+S D + RLW+ Sbjct: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703 Score = 52.8 bits (125), Expect = 5e-07 Identities = 27/114 (23%), Positives = 48/114 (42%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 H +IT L GG S S D + +W N L+GH + F +++ Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + G D +K W + C T GH+ + ++ + +++ + D R+WD Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219 Score = 50.4 bits (119), Expect = 3e-06 Identities = 30/147 (20%), Positives = 61/147 (41%) Query: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152 + +TCL S G DG+++I+ +GE GH + ++ G + SG Sbjct: 66 QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125 Query: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLG 212 D + +W + S + KGHK I + +V++ +D + WD C Sbjct: 126 SKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFK 185 Query: 213 VLADCGSSINGVAVGAADNSINLGSPE 239 + + + G+ + + + + G+ + Sbjct: 186 TMVGHRTEVWGLVLLSEEKRLITGASD 212 Score = 50.4 bits (119), Expect = 3e-06 Identities = 47/202 (23%), Positives = 80/202 (39%), Gaps = 14/202 (6%) Query: 74 ENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGH 133 EN++ K L+ T + + + C+ S L S D T+KI+ + L GH Sbjct: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590 Query: 134 VFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVS 193 V C G ++ +G D +KIW + C + H ++ V + + Sbjct: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFT 650 Query: 194 ASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAA---------DNSINLGSPEQMP-- 242 A +D + WD + + L I +AV + D S+ L + P Sbjct: 651 AGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLI 710 Query: 243 --SEREVGTEAKM-LLLAREDK 261 ERE+ EA+ +A+ED+ Sbjct: 711 LEEEREMEREAEYEESVAKEDQ 732 Score = 47.4 bits (111), Expect = 2e-05 Identities = 28/87 (32%), Positives = 38/87 (43%) Query: 118 IWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKG 177 IW GE +L+G +V C P GL + G D ++I+S VTF GHK Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108 Query: 178 GILDTAIVDRGRNVVSASRDGTARLWD 204 I G + S S+D +WD Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWD 135 Score = 38.1 bits (87), Expect = 0.014 Identities = 26/115 (22%), Positives = 47/115 (40%), Gaps = 5/115 (4%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFF-PSGLVV 149 H + L SS + V S+ ++KIW S + R + + C FF P V Sbjct: 414 HRSDVRTLSFSS-DNIAVLSAAADSIKIWNRSTLQCIRTM---TCEYALCSFFVPGDRQV 469 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 + G +L+++ + + T H G + ++ R V+ D + + WD Sbjct: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524 Score = 34.7 bits (78), Expect = 0.15 Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 12/127 (9%) Query: 127 RRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVD 186 R + GH DV F + VLS D+ +KIW+ C+ T L + V Sbjct: 408 RITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYA--LCSFFVP 464 Query: 187 RGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI---------NGVAVGAADNSINLGS 237 R VV ++ G +L+D L + ++ G G AD S+ Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524 Query: 238 PEQMPSE 244 E + E Sbjct: 525 FELVKDE 531 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 67.8 bits (164), Expect = 2e-11 Identities = 32/114 (28%), Positives = 55/114 (48%) Query: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150 HT + + +++ L V+ S G++++W ++ R L GH ++ F P G V Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121 Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 SG D +K+W CV ++GH + G+ + SA+ D T +LWD Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175 Score = 57.8 bits (138), Expect = 2e-08 Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 11/154 (7%) Query: 89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148 R H++++ CL S G S++ D T+K+W + G++ GH VN F P+ + Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203 Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208 + SG D ++ W E V +G G + G + S +D + R++ Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPE 262 Query: 209 ACLGV----------LADCGSSINGVAVGAADNS 232 C V LA C + GVA ++ S Sbjct: 263 RCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVS 296 Score = 54.7 bits (130), Expect = 1e-07 Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 1/122 (0%) Query: 91 HTKSITCLDISSRGG-LGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVV 149 H +++ L + G L + D + +W + L GH V R ++ Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78 Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 209 ++G +++W E A + T GHK I G V S S+D +LWD R Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138 Query: 210 CL 211 C+ Sbjct: 139 CV 140 Score = 46.6 bits (109), Expect = 4e-05 Identities = 50/214 (23%), Positives = 90/214 (42%), Gaps = 26/214 (12%) Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204 SG ++ +GG D ++ +WS +C+++ GH + + +V+ S+ G+ R+WD Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91 Query: 205 CGRSACLGVLADCGSSI---------NGVAVGAADNSINL-------------GSPEQMP 242 + L L ++I VA G+ D +I L G + + Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151 Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTF-LSGFLLLAGTQD 300 R + K L A +D ++ L + +++ F G + N F + +LL +G+ D Sbjct: 152 CLR-FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210 Query: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDG 334 I D+ + V I PV S+L DG Sbjct: 211 RTIRFWDLEKFQV-VSCIEGEPGPVRSVLFNPDG 243 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.419 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,411,773 Number of Sequences: 37866 Number of extensions: 678302 Number of successful extensions: 3131 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 188 Number of HSP's successfully gapped in prelim test: 74 Number of HSP's that attempted gapping in prelim test: 1610 Number of HSP's gapped (non-prelim): 1129 length of query: 392 length of database: 18,247,518 effective HSP length: 104 effective length of query: 288 effective length of database: 14,309,454 effective search space: 4121122752 effective search space used: 4121122752 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.