Guide to the Human Genome
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Search of human proteins with 13376751

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13376751 proteasomal ATPase-associated factor 1 [Homo
sapiens]
         (392 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens]     796   0.0  
gi|19913369 transducin beta-like 3 [Homo sapiens]                      92   1e-18
gi|16554629 WD repeat domain 5 [Homo sapiens]                          87   3e-17
gi|16554627 WD repeat domain 5 [Homo sapiens]                          87   3e-17
gi|32189425 WD repeat domain 69 [Homo sapiens]                         85   1e-16
gi|23199987 WD repeat domain 5B [Homo sapiens]                         84   3e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     80   4e-15
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    78   1e-14
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    77   2e-14
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    77   2e-14
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    77   2e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     76   6e-14
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    74   2e-13
gi|157266266 WD repeat domain 86 [Homo sapiens]                        74   3e-13
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    73   5e-13
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    71   2e-12
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    71   2e-12
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       71   2e-12
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    71   2e-12
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    71   2e-12
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    70   4e-12
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    69   6e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             69   7e-12
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             69   7e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             69   7e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    69   7e-12
gi|13376840 WD repeat domain 61 [Homo sapiens]                         69   7e-12
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    69   1e-11
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               68   1e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     68   2e-11

>gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens]
          Length = 392

 Score =  796 bits (2057), Expect = 0.0
 Identities = 392/392 (100%), Positives = 392/392 (100%)

Query: 1   MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN 60
           MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN
Sbjct: 1   MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVN 60

Query: 61  EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ 120
           EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ
Sbjct: 61  EINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQ 120

Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180
           ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL
Sbjct: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180

Query: 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240
           DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ
Sbjct: 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240

Query: 241 MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD 300
           MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD
Sbjct: 241 MPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQD 300

Query: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA 360
           GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA
Sbjct: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGA 360

Query: 361 DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL 392
           DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL
Sbjct: 361 DCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL 392


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 17/200 (8%)

Query: 86  TFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPS 145
           T  R H K I  + I+    L  + S D T K+W     +L  V  GH   + C +F P 
Sbjct: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPM 532

Query: 146 GLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
             V+ +   D  +K+W+ +D SC+ TF+GH   +L  A V RG  ++S+  DG  +LW  
Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592

Query: 206 GRSACLGVL---------ADCGSSINGVAVGAADNSINL--------GSPEQMPSEREVG 248
             + C+  L           C    +    GA+D+ + L         + EQ   E +V 
Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652

Query: 249 TEAKMLLLAREDKKLQCLGL 268
            + ++  L  E + L+ LGL
Sbjct: 653 RQQELDNLLHEKRYLRALGL 672



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 21/311 (6%)

Query: 90  IHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP--SGL 147
           IHT  +  +       L  +   DG +++W            G    V+   F P  + L
Sbjct: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166

Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
           ++ S   DA +++WS +D SC+     H   +   A    G  ++S+ RD    +WD   
Sbjct: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD--- 223

Query: 208 SACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLG 267
                 L  C ++       + + ++ L  PE+  S+  V +     L A +   L+   
Sbjct: 224 ------LQSCQATRTVPVFESVEAAVLL--PEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275

Query: 268 LQSRQLVFLFI-----GSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSG 322
             S Q V+        G +  +C    +  ++L  T D N+   + RS R   Q    S 
Sbjct: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335

Query: 323 APV-LSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEK--QIYTCC 379
             + +  L   D  +    +  C  V +      ++     D V  +  + K     +C 
Sbjct: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCA 395

Query: 380 RDGLVRRYQLS 390
           +D  VR ++++
Sbjct: 396 KDQSVRIWRMN 406



 Score = 33.5 bits (75), Expect = 0.34
 Identities = 46/208 (22%), Positives = 82/208 (39%), Gaps = 25/208 (12%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIW---SAE 164
           V +S    +K+++      + +L GH   V     F  G +  S   D  ++IW    A 
Sbjct: 351 VVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAG 409

Query: 165 DASCVVTFKGHKGGILDTAIVDRGRN--VVSASRDGTARLWDCGRSACLGVLADCGSSIN 222
              CV    GH   +  T    R +   +V+ S+D T +LW   ++    +L+   +  N
Sbjct: 410 QVMCVAQGSGHTHSV-GTVCCSRLKESFLVTGSQDCTVKLWPLPKA----LLSKNTAPDN 464

Query: 223 GVAVGAADNSINLGSPEQMPSEREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLF 277
           G  +  A  +       Q   ++++ + A     K+L    +D+  +   L   QL+ +F
Sbjct: 465 GPILLQAQTT-------QRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVF 517

Query: 278 IGSDAFNCCTFLSGF--LLLAGTQDGNI 303
            G      C   S    +L   + DG I
Sbjct: 518 SGHRRGLWCVQFSPMDQVLATASADGTI 545


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 44/126 (34%), Positives = 63/126 (50%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I+ +  SS   L VS+S D T+KIW  S+G+  + L+GH   V CC F P   +++
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  ++IW  +   C+ T   H   +        G  +VS+S DG  R+WD     C
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 211 LGVLAD 216
           L  L D
Sbjct: 206 LKTLID 211



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 38/134 (28%), Positives = 61/134 (45%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HTK+++ +  S  G    SSS D  +KIW A +G+  + + GH   ++   +     +++
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S   D  LKIW      C+ T KGH   +       +   +VS S D + R+WD     C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 211 LGVLADCGSSINGV 224
           L  L      ++ V
Sbjct: 164 LKTLPAHSDPVSAV 177



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149
           H+  ++ +  +  G L VSSS DG  +IW  ++G+ L+ +++     V+  +F P+G  +
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204
           L+  +D  LK+W      C+ T+ GHK     I     V  G+ +VS S D    +W+
Sbjct: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 35/92 (38%), Positives = 44/92 (47%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N  L+  L GH   V+  +F P+G  + S   D  +KIW A D     T  GHK GI D 
Sbjct: 34  NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           A       +VSAS D T ++WD     CL  L
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151
           ++ +  S  G   ++++ D T+K+W  S G+  +   GH  +  C    F    G  ++S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW--DC 205
           G  D  + IW+ +    V   +GH   ++ TA       + SA+   D T +LW  DC
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 44/126 (34%), Positives = 63/126 (50%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I+ +  SS   L VS+S D T+KIW  S+G+  + L+GH   V CC F P   +++
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  ++IW  +   C+ T   H   +        G  +VS+S DG  R+WD     C
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 211 LGVLAD 216
           L  L D
Sbjct: 206 LKTLID 211



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 38/134 (28%), Positives = 61/134 (45%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HTK+++ +  S  G    SSS D  +KIW A +G+  + + GH   ++   +     +++
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S   D  LKIW      C+ T KGH   +       +   +VS S D + R+WD     C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 211 LGVLADCGSSINGV 224
           L  L      ++ V
Sbjct: 164 LKTLPAHSDPVSAV 177



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149
           H+  ++ +  +  G L VSSS DG  +IW  ++G+ L+ +++     V+  +F P+G  +
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204
           L+  +D  LK+W      C+ T+ GHK     I     V  G+ +VS S D    +W+
Sbjct: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 35/92 (38%), Positives = 44/92 (47%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N  L+  L GH   V+  +F P+G  + S   D  +KIW A D     T  GHK GI D 
Sbjct: 34  NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           A       +VSAS D T ++WD     CL  L
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151
           ++ +  S  G   ++++ D T+K+W  S G+  +   GH  +  C    F    G  ++S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW--DC 205
           G  D  + IW+ +    V   +GH   ++ TA       + SA+   D T +LW  DC
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 54/214 (25%), Positives = 92/214 (42%), Gaps = 23/214 (10%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           R H+  I  L  ++ G   ++ S D T+ +W A  G    +L GH  +++   F     +
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275

Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208
           +L+G MD   K+W A +  CV T  GH   ILD+     G+ + +AS DGTAR++     
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335

Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGL 268
            C+  L      I+ ++     N +  GS                      DK  +    
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGS---------------------SDKTARIWDA 374

Query: 269 QSRQLVFLFIG--SDAFNCCTFLSGFLLLAGTQD 300
           Q+ Q + +  G   + F+C     G +++ G++D
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 43/150 (28%), Positives = 68/150 (45%), Gaps = 1/150 (0%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFF-PSGL 147
           + H   +T + ++  G   ++ S D T K+W  ++GE    LEGH   V    F  P G 
Sbjct: 89  KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148

Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
            + +G  D   K+WS E   C  TF+GH   I+  +   +   V + S D TA+LWD   
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208

Query: 208 SACLGVLADCGSSINGVAVGAADNSINLGS 237
              +  L    + I  ++   + + I  GS
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGS 238



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 2/108 (1%)

Query: 96  TCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMD 155
           +C D +  G L  ++S DGT +I+ A+  +    LEGH  +++   F P G  +L+G  D
Sbjct: 309 SCFDYT--GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366

Query: 156 AQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
              +IW A+   C+   +GH   I   A   +G  V++ S+D T R+W
Sbjct: 367 KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 46/195 (23%), Positives = 77/195 (39%), Gaps = 23/195 (11%)

Query: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
           + S D T K+W    G+      GH  ++ C  F P   +V +G MD   K+W  ++   
Sbjct: 152 TGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE 211

Query: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228
           V T +GH   I+  +    G  +++ S D T  +WD          AD G  +N      
Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----------ADTGRKVN------ 255

Query: 229 ADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSD--AFNCC 286
               I +G   ++ S      +  ++L    DK  +     + + V    G D    + C
Sbjct: 256 ----ILIGHCAEI-SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 287 TFLSGFLLLAGTQDG 301
              +G L+   + DG
Sbjct: 311 FDYTGKLIATASADG 325



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 23/71 (32%), Positives = 39/71 (54%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I+ +  + +G   ++ S+D T +IW A  G+  +VLEGH  ++  C F   G +V+
Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVI 403

Query: 151 SGGMDAQLKIW 161
           +G  D   +IW
Sbjct: 404 TGSKDNTCRIW 414



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 3/97 (3%)

Query: 117 KIWQASNGE--LRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKG 174
           K+ Q SN    L +VL+ H+  +       SG   ++G  D   K+W       + T +G
Sbjct: 73  KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132

Query: 175 HKGGILDTAIVD-RGRNVVSASRDGTARLWDCGRSAC 210
           H+  +   A  +  G  + + S D T +LW      C
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 169


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 42/126 (33%), Positives = 60/126 (47%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I+ +  SS     VS+S D T+K+W   +G+  + L+GH   V CC F P   +++
Sbjct: 82  HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  +KIW  +   C+ T   H   +        G  +VS S DG  R+WD     C
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC 201

Query: 211 LGVLAD 216
           L  L D
Sbjct: 202 LKTLVD 207



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 1/122 (0%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H+  + C + +    L +S S D T+KIW+   G+  + L  H   V+   F  SG +++
Sbjct: 124 HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIV 183

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILD-TAIVDRGRNVVSASRDGTARLWDCGRSA 209
           SG  D   +IW A    C+ T        +        G+ +++A+ D T +LWD  R  
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243

Query: 210 CL 211
           CL
Sbjct: 244 CL 245



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 37/147 (25%), Positives = 65/147 (44%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT++++ +  S  G    SSS D  + IW A +G+  + L GH  +++   +      ++
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S   D  LK+W      C+ T KGH   +           ++S S D T ++W+     C
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 211 LGVLADCGSSINGVAVGAADNSINLGS 237
           L  L+     ++ V    + + I  GS
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGS 186



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 61/224 (27%), Positives = 91/224 (40%), Gaps = 19/224 (8%)

Query: 102 SRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIW 161
           ++  L +SSS + + ++ +  N  L+  L GH   V+  +F P+G  + S   D  + IW
Sbjct: 9   AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68

Query: 162 SAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI 221
            A D     T  GH   I D A       +VSAS D T +LWD     CL  L    + +
Sbjct: 69  GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128

Query: 222 NGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSD 281
                    N I  GS ++     EV T           K L+ L   S       + + 
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKT----------GKCLKTLSAHSDP-----VSAV 173

Query: 282 AFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPV 325
            FNC    SG L+++G+ DG     D  S +    ++     PV
Sbjct: 174 HFNC----SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 4/118 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGE-LRRVLEGHVFDVNCCRFFPSGLVV 149
           H+  ++ +  +  G L VS S DG  +IW A++G+ L+ +++     V+  +F P+G  +
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGG---ILDTAIVDRGRNVVSASRDGTARLWD 204
           L+  +D  LK+W      C+ T+ GHK     I     V  G+ +VS S D    +W+
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNC--CRF-FPSGLVVLS 151
           ++ +  S  G   ++++ D T+K+W  S G   +   GH  +  C    F    G  ++S
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272

Query: 152 GGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS--RDGTARLW 203
           G  D  + IW+ +    V   +GH   ++  A       + SA+   D T +LW
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 44/154 (28%), Positives = 68/154 (44%), Gaps = 9/154 (5%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   +     S  G   VS   D   ++W   + +  R+  GH+ DVNC RF P+   V 
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +G  D  +++W   + +CV  F GHKG I        GR + + + DG   LWD G    
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703

Query: 211 LGVLADCGSSING---------VAVGAADNSINL 235
           +G L     ++           +A G+ DN++ L
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 30/114 (26%), Positives = 46/114 (40%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   + C           + S D T+++W   NG   R+  GH   ++   F P+G  + 
Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           +G  D ++ +W       V   KGH   +        G  + S S D T RLWD
Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 46/183 (25%), Positives = 71/183 (38%), Gaps = 40/183 (21%)

Query: 93  KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELR------------------------- 127
           + +T +D++    L      D T+++W  +  +LR                         
Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDE 530

Query: 128 ------RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181
                 ++L GH   V    F P    +LS   D  +++WS +  +C+V +KGH   + D
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590

Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACL----GVLADCG-----SSINGVAVGAADNS 232
           T     G   VS   D  ARLW       L    G LAD        + N VA G+AD +
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650

Query: 233 INL 235
           + L
Sbjct: 651 VRL 653



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 23/73 (31%), Positives = 35/73 (47%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I  L  S  G    + +TDG + +W   +G +   L+GH   V   RF   G ++ 
Sbjct: 668 HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727

Query: 151 SGGMDAQLKIWSA 163
           SG MD  +++W A
Sbjct: 728 SGSMDNTVRLWDA 740


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 36/104 (34%), Positives = 55/104 (52%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDAS 167
           VS+S D T+K+W    G+  R L+GH   V    F  SG ++ S   D  +K+W  +   
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 183

Query: 168 CVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACL 211
           C+ T  GH   +   AI+  G ++VSASRD T ++W+     C+
Sbjct: 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV 227



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 47/191 (24%), Positives = 79/191 (41%), Gaps = 1/191 (0%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT S+  +     G L  S S D T+K+W     E  R + GH  +V+     P+G  ++
Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV 208

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S   D  +K+W  +   CV TF GH+  +        G  + S S D T R+W      C
Sbjct: 209 SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC 268

Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270
              L +    +  ++  A ++S +  S       ++ G     LL    DK ++   + +
Sbjct: 269 KAELREHEHVVECIS-WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST 327

Query: 271 RQLVFLFIGSD 281
              +   +G D
Sbjct: 328 GMCLMTLVGHD 338



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 20/144 (13%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPS----- 145
           H + +  +  +  G L  S S D T+++W  +  E +  L  H   V C  + P      
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292

Query: 146 ---------------GLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRN 190
                          G  +LSG  D  +K+W      C++T  GH   +        G+ 
Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352

Query: 191 VVSASRDGTARLWDCGRSACLGVL 214
           ++S + D T R+WD     C+  L
Sbjct: 353 ILSCADDKTLRVWDYKNKRCMKTL 376



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 1/125 (0%)

Query: 82  APYTTFSRIHTKSITCLDISSRGG-LGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCC 140
           AP +++S I   + +    S + G   +S S D T+K+W  S G     L GH   V   
Sbjct: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV 344

Query: 141 RFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTA 200
            F   G  +LS   D  L++W  ++  C+ T   H+  +           VV+ S D T 
Sbjct: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404

Query: 201 RLWDC 205
           ++W+C
Sbjct: 405 KVWEC 409



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 29/97 (29%), Positives = 44/97 (45%)

Query: 130 LEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGR 189
           L GH   V    F P   V++S   DA +K+W  E      T KGH   + D +    G+
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 190 NVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV 226
            + S S D T +LWD     C+  +     +++ VA+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI 200


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           ITCL     G   VS S D T+K+W A  G+  R L GH   V   +   +  +++SG  
Sbjct: 266 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 321

Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           D  LK+W+AE   C+ T  GH   +    + +  + VVS SRD T R+WD     CL VL
Sbjct: 322 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 379

Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239
               +++         V  GA D  + +  PE
Sbjct: 380 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 411



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT ++ C+ +  +    VS S D T+++W    G+   VL GHV  V C ++   G  V+
Sbjct: 342 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 397

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  +K+W  E  +C+ T +GH   +        G +VVS S D + R+WD     C
Sbjct: 398 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 455

Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235
           +  L    S  +G+ +       G AD+++ +
Sbjct: 456 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 487



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%)

Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
           R  + +S STD T+K+W A  GE    L GH   V C         V+SG  DA L++W 
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 369

Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221
            E   C+    GH   +    +   GR VVS + D   ++WD     CL  L    + + 
Sbjct: 370 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427

Query: 222 ----NGVAV--GAADNSINLGSPE 239
               +G+ V  G+ D SI +   E
Sbjct: 428 SLQFDGIHVVSGSLDTSIRVWDVE 451



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++ C+    R    VS + D  +K+W          L+GH   V   +F   G+ V+
Sbjct: 382 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 437

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG +D  +++W  E  +C+ T  GH+   L + +  +   +VS + D T ++WD     C
Sbjct: 438 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 495

Query: 211 LGVL 214
           L  L
Sbjct: 496 LQTL 499



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%)

Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181
           GEL+  +VL+GH   V  C  F  G  ++SG  D  LK+WSA    C+ T  GH GG+  
Sbjct: 250 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 308

Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           + +  R   ++S S D T ++W+     C+  L
Sbjct: 309 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 339



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162
           VS S D ++++W    G     L GH       +   SG+     +++SG  D+ +KIW 
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 489

Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            +   C+ T +G   H+  +  T +      V+++S DGT +LWD
Sbjct: 490 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 532



 Score = 33.1 bits (74), Expect = 0.44
 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130
           H  ++TCL  +      ++SS DGT+K+W    GE  R L
Sbjct: 505 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           ITCL     G   VS S D T+K+W A  G+  R L GH   V   +   +  +++SG  
Sbjct: 384 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 439

Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           D  LK+W+AE   C+ T  GH   +    + +  + VVS SRD T R+WD     CL VL
Sbjct: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 497

Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239
               +++         V  GA D  + +  PE
Sbjct: 498 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 529



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT ++ C+ +  +    VS S D T+++W    G+   VL GHV  V C ++   G  V+
Sbjct: 460 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 515

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  +K+W  E  +C+ T +GH   +        G +VVS S D + R+WD     C
Sbjct: 516 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 573

Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235
           +  L    S  +G+ +       G AD+++ +
Sbjct: 574 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 605



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%)

Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
           R  + +S STD T+K+W A  GE    L GH   V C         V+SG  DA L++W 
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487

Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221
            E   C+    GH   +    +   GR VVS + D   ++WD     CL  L    + + 
Sbjct: 488 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545

Query: 222 ----NGVAV--GAADNSINLGSPE 239
               +G+ V  G+ D SI +   E
Sbjct: 546 SLQFDGIHVVSGSLDTSIRVWDVE 569



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++ C+    R    VS + D  +K+W          L+GH   V   +F   G+ V+
Sbjct: 500 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 555

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG +D  +++W  E  +C+ T  GH+   L + +  +   +VS + D T ++WD     C
Sbjct: 556 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 613

Query: 211 LGVL 214
           L  L
Sbjct: 614 LQTL 617



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%)

Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181
           GEL+  +VL+GH   V  C  F  G  ++SG  D  LK+WSA    C+ T  GH GG+  
Sbjct: 368 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 426

Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           + +  R   ++S S D T ++W+     C+  L
Sbjct: 427 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 457



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162
           VS S D ++++W    G     L GH       +   SG+     +++SG  D+ +KIW 
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 607

Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            +   C+ T +G   H+  +  T +      V+++S DGT +LWD
Sbjct: 608 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 650



 Score = 33.1 bits (74), Expect = 0.44
 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130
           H  ++TCL  +      ++SS DGT+K+W    GE  R L
Sbjct: 623 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 51/152 (33%), Positives = 72/152 (47%), Gaps = 13/152 (8%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           ITCL     G   VS S D T+K+W A  G+  R L GH   V   +   +  +++SG  
Sbjct: 304 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 359

Query: 155 DAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           D  LK+W+AE   C+ T  GH   +    + +  + VVS SRD T R+WD     CL VL
Sbjct: 360 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVL 417

Query: 215 ADCGSSI-------NGVAVGAADNSINLGSPE 239
               +++         V  GA D  + +  PE
Sbjct: 418 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPE 449



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 13/152 (8%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT ++ C+ +  +    VS S D T+++W    G+   VL GHV  V C ++   G  V+
Sbjct: 380 HTSTVRCMHLHEKRV--VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVV 435

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  +K+W  E  +C+ T +GH   +        G +VVS S D + R+WD     C
Sbjct: 436 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNC 493

Query: 211 LGVLADCGSSINGVAV-------GAADNSINL 235
           +  L    S  +G+ +       G AD+++ +
Sbjct: 494 IHTLTGHQSLTSGMELKDNILVSGNADSTVKI 525



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 11/144 (7%)

Query: 103 RGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
           R  + +S STD T+K+W A  GE    L GH   V C         V+SG  DA L++W 
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 407

Query: 163 AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI- 221
            E   C+    GH   +    +   GR VVS + D   ++WD     CL  L    + + 
Sbjct: 408 IETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465

Query: 222 ----NGVAV--GAADNSINLGSPE 239
               +G+ V  G+ D SI +   E
Sbjct: 466 SLQFDGIHVVSGSLDTSIRVWDVE 489



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 6/124 (4%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++ C+    R    VS + D  +K+W          L+GH   V   +F   G+ V+
Sbjct: 420 HVAAVRCVQYDGRRV--VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVV 475

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG +D  +++W  E  +C+ T  GH+   L + +  +   +VS + D T ++WD     C
Sbjct: 476 SGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDIKTGQC 533

Query: 211 LGVL 214
           L  L
Sbjct: 534 LQTL 537



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 5/93 (5%)

Query: 124 GELR--RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILD 181
           GEL+  +VL+GH   V  C  F  G  ++SG  D  LK+WSA    C+ T  GH GG+  
Sbjct: 288 GELKSPKVLKGHDDHVITCLQF-CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS 346

Query: 182 TAIVDRGRNVVSASRDGTARLWDCGRSACLGVL 214
           + +  R   ++S S D T ++W+     C+  L
Sbjct: 347 SQM--RDNIIISGSTDRTLKVWNAETGECIHTL 377



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGL-----VVLSGGMDAQLKIWS 162
           VS S D ++++W    G     L GH       +   SG+     +++SG  D+ +KIW 
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGH-------QSLTSGMELKDNILVSGNADSTVKIWD 527

Query: 163 AEDASCVVTFKG---HKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            +   C+ T +G   H+  +  T +      V+++S DGT +LWD
Sbjct: 528 IKTGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSSDDGTVKLWD 570



 Score = 33.1 bits (74), Expect = 0.44
 Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL 130
           H  ++TCL  +      ++SS DGT+K+W    GE  R L
Sbjct: 543 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 37/114 (32%), Positives = 57/114 (50%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   +  LDIS       S S D T ++W        R+  GH+ DV+C +F P+   + 
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           +G  D  +++WSA+  + V  F GH+G +L  A    G+ + SA  D   +LWD
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 38/145 (26%), Positives = 59/145 (40%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   + C+          + STD T+++W A  G   R+  GH   V    F P+G  + 
Sbjct: 425 HLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLA 484

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S G D +LK+W     +     +GH   I           + SAS D + R+WD   + C
Sbjct: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544

Query: 211 LGVLADCGSSINGVAVGAADNSINL 235
                   S + GV  G   N +++
Sbjct: 545 SAPADGSSSELVGVYTGQMSNVLSV 569



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 55/210 (26%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 124 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTA 183
           G   ++L GH   V   RF      +LS   D  ++ W     +  V ++GH   + D  
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391

Query: 184 IVDRGRNVVSASRDGTARLWDCGRSACLGVLA------DC---GSSINGVAVGAADNSIN 234
           I        S S D TARLW   R+  L + A      DC     + N +A G+ D ++ 
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451

Query: 235 LGSPEQMPSER------------EVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SD 281
           L S +Q  S R                  K L  A ED++L+   L S  L     G +D
Sbjct: 452 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511

Query: 282 AFNCCTFL-SGFLLLAGTQDGNIYQLDVRS 310
                TF     L+ + + D ++   D+R+
Sbjct: 512 NITSLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 34.3 bits (77), Expect = 0.20
 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 11/75 (14%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIW-----------QASNGELRRVLEGHVFDV 137
           R HT +IT L  S   GL  S+S D ++++W             S+ EL  V  G + +V
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566

Query: 138 NCCRFFPSGLVVLSG 152
              +F    L++++G
Sbjct: 567 LSVQFMACNLLLVTG 581


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)

Query: 82  APYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRR------VLEGHVF 135
           A   T ++ H+ +I+    +  G    +SS D  +KIW    GE R       +++GH  
Sbjct: 263 ATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEG 322

Query: 136 DVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSAS 195
            V+ C F      ++SGG D  + IW   +    ++ KGH   ++D AI +  + ++SAS
Sbjct: 323 SVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS 382

Query: 196 RDGTARLWD 204
           +D T RLW+
Sbjct: 383 KDRTMRLWN 391



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 11/123 (8%)

Query: 91  HTKSIT--CLDISSRGGLGVSSSTDGTMKIWQA-SNGELRRVLEGHVFDVNCCRFFPSGL 147
           HT+SIT  C D  S+    VS   D  +KIW   S   L  + + H   ++ C F  SG 
Sbjct: 229 HTRSITSCCFDPDSQRVASVS--LDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGH 286

Query: 148 VVLSGGMDAQLKIWSAED------ASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201
            + +   D  LKIW+          +CV   +GH+G +           ++S   D T  
Sbjct: 287 FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVA 346

Query: 202 LWD 204
           +WD
Sbjct: 347 IWD 349



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 1/78 (1%)

Query: 128 RVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGH-KGGILDTAIVD 186
           ++L GH   V+ C F      +LSG  D  +K+W   D S V  F+   K  +++ +I  
Sbjct: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 187 RGRNVVSASRDGTARLWD 204
               V++AS D T R WD
Sbjct: 156 DSSRVIAASYDKTVRAWD 173



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 3/106 (2%)

Query: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG-GMDAQLKIWSAEDA 166
           +++S D T++ W    G+L   +    F V+ C+F P G  V+SG  +D  + I  AE+ 
Sbjct: 161 IAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIMDAENI 219

Query: 167 SCVVTFKGHKGGILDTAIVD-RGRNVVSASRDGTARLWDCGRSACL 211
           + V   K H    + +   D   + V S S D   ++WD    A L
Sbjct: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265



 Score = 35.8 bits (81), Expect = 0.068
 Identities = 21/94 (22%), Positives = 39/94 (41%), Gaps = 5/94 (5%)

Query: 129 VLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTF-KGHKGGILDTAIVDR 187
           + + H   +  C F P    V S  +D  +KIW     + ++T  K H   I +      
Sbjct: 225 IKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFS 284

Query: 188 GRNVVSASRDGTARLWDCGRSACLGVLADCGSSI 221
           G  + ++S D   ++W    +   G   +CG+ +
Sbjct: 285 GHFLCTSSWDKNLKIW----NVHTGEFRNCGACV 314


>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 60/225 (26%), Positives = 90/225 (40%), Gaps = 29/225 (12%)

Query: 94  SITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGG 153
           S  C + ++ GGL V+ STDGT K+WQ ++G   + L GH   V C      G    +G 
Sbjct: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212

Query: 154 MDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGV 213
            DA ++ W       +  F+ H+G ++   +V+  R V S S D T + W          
Sbjct: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVN--RLVYSGSADRTVKCW---------- 260

Query: 214 LADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQL 273
           LAD G  +        + S              +   A  L     D   +    QS +L
Sbjct: 261 LADTGECVRTFTAHRRNVS-------------ALKYHAGTLFTGSGDACARAFDAQSGEL 307

Query: 274 VFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVR----SPRAP 314
             +F G      C  + G +L   + DG +   DVR    +PR P
Sbjct: 308 RRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPP 352



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 4/116 (3%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           R HT ++ CL + + G    + STD T++ W   +GE  RV   H   V C        +
Sbjct: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRL 247

Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           V SG  D  +K W A+   CV TF  H+  +  +A+      + + S D  AR +D
Sbjct: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNV--SALKYHAGTLFTGSGDACARAFD 301



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 12/117 (10%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I  L +S  G   ++ S DGT ++W  ++G+   +L+GH   V  C+         
Sbjct: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDR----GRNVVSASRDGTARLW 203
           S   D  ++ W      C+  ++GH      T+IV+R       + S+S D TAR+W
Sbjct: 74  SA--DCTIRRWDVLTGQCLQVYRGH------TSIVNRILVANNQLFSSSYDRTARVW 122



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 29/103 (28%), Positives = 41/103 (39%), Gaps = 2/103 (1%)

Query: 124 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTA 183
           G   RV   H   +N     P G  +L+G  D   ++WS  D  C    +GH+  +    
Sbjct: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64

Query: 184 IVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV 226
           + D      + S D T R WD     CL V     S +N + V
Sbjct: 65  LEDEA--AFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV 105



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 16/114 (14%)

Query: 111 STDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
           S D T++ W    G+  +V  GH   VN  R   +   + S   D   ++WS +      
Sbjct: 74  SADCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSR 131

Query: 171 TFKGHKGGILDTAI--------------VDRGRNVVSASRDGTARLWDCGRSAC 210
            F+GH+  +L  A                  G  +V+ S DGTA++W      C
Sbjct: 132 EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 21/225 (9%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N  + R L GH   ++CCRF     ++ S G D    +W  E     V F GH G ++  
Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSL 190

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242
           ++   GR  VS + D + +LWD   S C        S IN VA      +   GS +   
Sbjct: 191 SLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATC 250

Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302
              ++  + ++L+ + ++             +   I S AF+     SG LLLAG  D N
Sbjct: 251 RLFDLRADQELLMYSHDN-------------IICGITSVAFS----RSGRLLLAGYDDFN 293

Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346
               D ++  RA V   H +    L +    DG   + G    F+
Sbjct: 294 CNIWDAMKGDRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 49/182 (26%), Positives = 75/182 (41%), Gaps = 7/182 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  ++C        + ++SS D T  +W    G+      GH  DV      P G   +
Sbjct: 142 HTGYLSCCRFLDDNQI-ITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  DA +K+W   D+ C  TF GH+  I   A    G    + S D T RL+D      
Sbjct: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260

Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266
           L + +     CG  I  VA   +   +  G  +   +  +     +  +LA  D ++ CL
Sbjct: 261 LLMYSHDNIICG--ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCL 318

Query: 267 GL 268
           G+
Sbjct: 319 GV 320



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 2/149 (1%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H+  +  L ++  G   VS + D ++K+W   +   R+   GH  D+N   FFP+G    
Sbjct: 183 HSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFT 242

Query: 151 SGGMDAQLKIWS--AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208
           +G  DA  +++   A+    + +      GI   A    GR +++   D    +WD  + 
Sbjct: 243 TGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKG 302

Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGS 237
              GVLA   + ++ + V     ++  GS
Sbjct: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGS 331



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 24/68 (35%), Positives = 33/68 (48%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           IT +  S  G L ++   D    IW A  G+   VL GH   V+C      G+ V +G  
Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 155 DAQLKIWS 162
           D+ LKIW+
Sbjct: 333 DSFLKIWN 340



 Score = 29.6 bits (65), Expect = 4.9
 Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 19/175 (10%)

Query: 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAAD 230
           T +GH   I         R +VSAS+DG   +WD   +  +  +    S +   A   + 
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109

Query: 231 NSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLS 290
           N +  G  + + S   + T    + ++RE                L   +   +CC FL 
Sbjct: 110 NFVACGGLDNICSIYSLKTREGNVRVSRE----------------LPGHTGYLSCCRFLD 153

Query: 291 GFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDG--FIASQGDGS 343
              ++  + D      D+ + +  V     SG  V+SL    DG  F++   D S
Sbjct: 154 DNQIITSSGDTTCALWDIETGQQTVGFAGHSG-DVMSLSLAPDGRTFVSGACDAS 207


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 40/121 (33%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVL-----EGHVFDVNCCRFF 143
           R H  ++T L + + G   +SSS D   + W  S+ +  RVL     E     + C +F 
Sbjct: 303 RAHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFH 359

Query: 144 PSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
           P GL+  +G MD+Q+KIW  ++ + V  F GH G I   A  + G  + +A+ D + +LW
Sbjct: 360 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419

Query: 204 D 204
           D
Sbjct: 420 D 420



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 47/181 (25%), Positives = 84/181 (46%), Gaps = 11/181 (6%)

Query: 28  PPGKPSLYGSLTCQGIG-LDGI-PEVTAS--EGFTVNEINKKSIHISCPKENASSKFLAP 83
           P  +PS+ G+     +G L G+ PE+     +  TV    +K    + P+E    + L+ 
Sbjct: 147 PSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSK 206

Query: 84  YTTFSR---IHTKSIT---CLDIS-SRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFD 136
           Y   +    +H+ SI     LD+  S     ++   D  + ++  S+ ++   L+GH   
Sbjct: 207 YRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK 266

Query: 137 VNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASR 196
           V    F PS  +V S   DA ++IWS  +ASCV   + H+  +   ++   G  ++S+S 
Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 326

Query: 197 D 197
           D
Sbjct: 327 D 327



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 43/197 (21%), Positives = 78/197 (39%), Gaps = 21/197 (10%)

Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208
           +L+GG D  + ++       + T KGH   +           V SAS D T R+W    +
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296

Query: 209 ACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGL 268
           +C+ V+    S++ G+++ A  + +   S +Q  +  ++ T    +L    D+   C   
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT--GRVLTKVTDETSGC--- 351

Query: 269 QSRQLVFLFIGSDAFNCCTF-LSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLS 327
                        +  C  F   G +   GT D  I   D++  R  V        P+ S
Sbjct: 352 -------------SLTCAQFHPDGLIFGTGTMDSQIKIWDLKE-RTNVANFPGHSGPITS 397

Query: 328 LLSVRDG-FIASQGDGS 343
           +    +G ++A+  D S
Sbjct: 398 IAFSENGYYLATAADDS 414



 Score = 33.1 bits (74), Expect = 0.44
 Identities = 25/114 (21%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLE-GHVFDVNCCRFFPSGLVV 149
           H+  IT +  S  G    +++ D ++K+W     +  + L+  + F+V    F  SG  +
Sbjct: 391 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL 450

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
             GG D Q  I+  +  + ++ F  H G     A     + + S   D + + +
Sbjct: 451 ALGGTDVQ--IYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147
           H +++  L  S+  GL V+ S D ++ +W    A++  LRRVL GH   VN   F    +
Sbjct: 319 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 376

Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
           V  SG  D  +K+WS      V T  GHK GI    +  R R VVS S D T RLWD   
Sbjct: 377 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 432

Query: 208 SACLGVL 214
            ACL VL
Sbjct: 433 GACLRVL 439



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H + I CL    R  L VS S+D T+++W    G   RVLEGH   V C RF      ++
Sbjct: 402 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 457

Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201
           SG  D ++K+W  + A          C+ T   H G +      +    ++S+S D T  
Sbjct: 458 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 515

Query: 202 LWD 204
           +WD
Sbjct: 516 IWD 518



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           ++K + CL         +S   D ++KIW  ++ E  +VL GH   V C ++     V++
Sbjct: 239 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 294

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +G  D+ +++W       + T   H   +L          +V+ S+D +  +WD   +  
Sbjct: 295 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 352

Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251
           +    VL    +++N V          + D +I + S       R +             
Sbjct: 353 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 412

Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310
            ++++    D  ++   ++    + +  G +    C       +++G  DG I   D+++
Sbjct: 413 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 472

Query: 311 ---PRAPVQVI 318
              PRAP   +
Sbjct: 473 ALDPRAPASTL 483


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 38/114 (33%), Positives = 49/114 (42%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H++++      S G    SSS D T KIW  ++   R  L GH   VN   FFP    +L
Sbjct: 435 HSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL 494

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           +   D  L IW A    C  +  GH   I D     RG  + S    G  +LWD
Sbjct: 495 TSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 1/174 (0%)

Query: 68  HISCPKENAS-SKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGEL 126
           +++  KE+ S +KF        R+H   ++C+ +     + VS   D   K+       +
Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNV 386

Query: 127 RRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVD 186
                GH   ++ C F PSG  + +   D  +K+W      C++TF+GH   +       
Sbjct: 387 LLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHS 446

Query: 187 RGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQ 240
            G  V S+S D T+++WD     C   L     S+N +      N++   S ++
Sbjct: 447 CGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADK 500



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 36/132 (27%), Positives = 50/132 (37%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  ++       G    +SS D T+K+W    G+     EGH   V  C +   G  V 
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           S  +D   KIW      C  T  GH   +           ++++S D T  +WD     C
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512

Query: 211 LGVLADCGSSIN 222
              L     SIN
Sbjct: 513 EQSLYGHMHSIN 524



 Score = 33.5 bits (75), Expect = 0.34
 Identities = 16/65 (24%), Positives = 34/65 (52%), Gaps = 1/65 (1%)

Query: 98  LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 157
           ++  S G +   +S +G + +    +GE+ +++ GH  + +   F   G ++ SGG D  
Sbjct: 568 VNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGT 626

Query: 158 LKIWS 162
           ++ WS
Sbjct: 627 VRTWS 631


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147
           H +++  L  S+  GL V+ S D ++ +W    A++  LRRVL GH   VN   F    +
Sbjct: 285 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342

Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
           V  SG  D  +K+WS      V T  GHK GI    +  R R VVS S D T RLWD   
Sbjct: 343 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 398

Query: 208 SACLGVL 214
            ACL VL
Sbjct: 399 GACLRVL 405



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H + I CL    R  L VS S+D T+++W    G   RVLEGH   V C RF      ++
Sbjct: 368 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 423

Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201
           SG  D ++K+W  + A          C+ T   H G +      +    ++S+S D T  
Sbjct: 424 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 481

Query: 202 LWD 204
           +WD
Sbjct: 482 IWD 484



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           ++K + CL         +S   D ++KIW  ++ E  +VL GH   V C ++     V++
Sbjct: 205 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 260

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +G  D+ +++W       + T   H   +L          +V+ S+D +  +WD   +  
Sbjct: 261 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 318

Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251
           +    VL    +++N V          + D +I + S       R +             
Sbjct: 319 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378

Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310
            ++++    D  ++   ++    + +  G +    C       +++G  DG I   D+++
Sbjct: 379 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 438

Query: 311 ---PRAPVQVI 318
              PRAP   +
Sbjct: 439 ALDPRAPASTL 449


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 51/127 (40%), Positives = 65/127 (51%), Gaps = 9/127 (7%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQ---ASNGELRRVLEGHVFDVNCCRFFPSGL 147
           H +++  L  S+  GL V+ S D ++ +W    A++  LRRVL GH   VN   F    +
Sbjct: 306 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363

Query: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
           V  SG  D  +K+WS      V T  GHK GI    +  R R VVS S D T RLWD   
Sbjct: 364 VSASG--DRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 419

Query: 208 SACLGVL 214
            ACL VL
Sbjct: 420 GACLRVL 426



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 15/123 (12%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H + I CL    R  L VS S+D T+++W    G   RVLEGH   V C RF      ++
Sbjct: 389 HKRGIACLQYRDR--LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIV 444

Query: 151 SGGMDAQLKIWSAEDA---------SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTAR 201
           SG  D ++K+W  + A          C+ T   H G +      +    ++S+S D T  
Sbjct: 445 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTIL 502

Query: 202 LWD 204
           +WD
Sbjct: 503 IWD 505



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 47/251 (18%), Positives = 99/251 (39%), Gaps = 29/251 (11%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           ++K + CL         +S   D ++KIW  ++ E  +VL GH   V C ++     V++
Sbjct: 226 NSKGVYCLQYDDEKI--ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIV 281

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +G  D+ +++W       + T   H   +L          +V+ S+D +  +WD   +  
Sbjct: 282 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATD 339

Query: 211 L---GVLADCGSSINGV-------AVGAADNSINLGSPEQMPSEREVGTEA--------- 251
           +    VL    +++N V          + D +I + S       R +             
Sbjct: 340 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399

Query: 252 -KMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 310
            ++++    D  ++   ++    + +  G +    C       +++G  DG I   D+++
Sbjct: 400 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 459

Query: 311 ---PRAPVQVI 318
              PRAP   +
Sbjct: 460 ALDPRAPASTL 470


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 62/225 (27%), Positives = 89/225 (39%), Gaps = 21/225 (9%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N  + R L GH   ++CCRF     +V S G D    +W  E      TF GH G ++  
Sbjct: 132 NVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSL 190

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242
           ++    R  VS + D +A+LWD     C        S IN +      N+   GS +   
Sbjct: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD--- 247

Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302
                      L   R D++L      S   +   I S +F+     SG LLLAG  D N
Sbjct: 248 -------ATCRLFDLRADQELM---TYSHDNIICGITSVSFS----KSGRLLLAGYDDFN 293

Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346
               D +++ RA V   H +    L +    DG   + G    F+
Sbjct: 294 CNVWDALKADRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 46/182 (25%), Positives = 71/182 (39%), Gaps = 7/182 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  ++C        + V+SS D T  +W    G+      GH  DV      P   + +
Sbjct: 142 HTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFV 200

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  DA  K+W   +  C  TF GH+  I        G    + S D T RL+D      
Sbjct: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260

Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266
           L   +     CG  I  V+   +   +  G  +   +  +     +  +LA  D ++ CL
Sbjct: 261 LMTYSHDNIICG--ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 318

Query: 267 GL 268
           G+
Sbjct: 319 GV 320



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 40/155 (25%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 85  TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144
           TTF+  HT  +  L ++    L VS + D + K+W    G  R+   GH  D+N   FFP
Sbjct: 178 TTFTG-HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP 236

Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHK--GGILDTAIVDRGRNVVSASRDGTARL 202
           +G    +G  DA  +++       ++T+       GI   +    GR +++   D    +
Sbjct: 237 NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296

Query: 203 WDCGRSACLGVLADCGSSINGVAVGAADNSINLGS 237
           WD  ++   GVLA   + ++ + V     ++  GS
Sbjct: 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 22/68 (32%), Positives = 32/68 (47%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           IT +  S  G L ++   D    +W A   +   VL GH   V+C      G+ V +G  
Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 155 DAQLKIWS 162
           D+ LKIW+
Sbjct: 333 DSFLKIWN 340


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 21/225 (9%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N  + R L GH   ++CCRF     +V S G D    +W  E A    TF GH G ++  
Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSL 190

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242
           ++    R  VS + D +++LWD     C        S IN V+      +   GS +   
Sbjct: 191 SLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250

Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302
              ++  + ++LL + ++             +   I S AF+     SG LLLAG  D N
Sbjct: 251 RLFDLRADQELLLYSHDN-------------IICGITSVAFS----KSGRLLLAGYDDFN 293

Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346
               D ++  RA V   H +    L +    DG   + G    F+
Sbjct: 294 CNVWDTLKGDRAGVLAGHDNRVSCLGVTD--DGMAVATGSWDSFL 336



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 85  TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144
           TTF+  H+  +  L +S      VS + D + K+W   +G  R+   GHV D+N   FFP
Sbjct: 178 TTFTG-HSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFP 236

Query: 145 SGLVVLSGGMDAQLKIWS--AEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202
           +G    +G  DA  +++   A+    + +      GI   A    GR +++   D    +
Sbjct: 237 NGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNV 296

Query: 203 WDCGRSACLGVLADCGSSINGVAVGAADNSINLGS 237
           WD  +    GVLA   + ++ + V     ++  GS
Sbjct: 297 WDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGS 331



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 46/182 (25%), Positives = 70/182 (38%), Gaps = 7/182 (3%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  ++C        + V+SS D T  +W     +      GH  DV      P     +
Sbjct: 142 HTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFV 200

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  DA  K+W   D  C  +F GH   I   +    G    + S D T RL+D      
Sbjct: 201 SGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQE 260

Query: 211 LGVLAD----CGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCL 266
           L + +     CG  I  VA   +   +  G  +   +  +     +  +LA  D ++ CL
Sbjct: 261 LLLYSHDNIICG--ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCL 318

Query: 267 GL 268
           G+
Sbjct: 319 GV 320



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 21/68 (30%), Positives = 32/68 (47%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           IT +  S  G L ++   D    +W    G+   VL GH   V+C      G+ V +G  
Sbjct: 273 ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 155 DAQLKIWS 162
           D+ L+IW+
Sbjct: 333 DSFLRIWN 340


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 38/155 (24%), Positives = 69/155 (44%)

Query: 85  TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144
           +T  R HT ++  +   S G   V++S D T+K+W     +    L  H+  V C +F P
Sbjct: 58  STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117

Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            G +++S   D  +K+W      CV ++  H G +        G  + +A  D T ++WD
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177

Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239
                 L       +++NG++   + N +   S +
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 212



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 50/210 (23%), Positives = 81/210 (38%), Gaps = 21/210 (10%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++TC++ S  G L  S S D T++IW  +      V   H   V    F   G   +
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +   D  +K+W+      + +   H   +        GR +VSAS D T +LWD     C
Sbjct: 82  TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141

Query: 211 LGVLADCGSSI-------NGVAVGAA--DNSINLGSPE--------QMPSEREVG----T 249
           +    + G  +       +G  + AA  DN++ +            Q+ S    G     
Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 201

Query: 250 EAKMLLLAREDKKLQCLGLQSRQLVFLFIG 279
               L+ A  D  L+ L L   +L++   G
Sbjct: 202 SGNYLITASSDSTLKILDLMEGRLLYTLHG 231



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 46/204 (22%), Positives = 76/204 (37%), Gaps = 27/204 (13%)

Query: 113 DGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTF 172
           D  + +W            GH   V C  F PSG ++ SG  D  ++IW          F
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 173 KGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNS 232
           + H   +        G++ V+AS D T ++W   R   L  L+     IN V        
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLS---QHINWVRCA----- 113

Query: 233 INLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFL--- 289
                        +   + ++++ A +DK ++     SR+ V  +     F   T++   
Sbjct: 114 -------------KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFH 158

Query: 290 -SGFLLLAGTQDGNIYQLDVRSPR 312
            SG  + A   D  +   DVR+ R
Sbjct: 159 PSGTCIAAAGMDNTVKVWDVRTHR 182



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%)

Query: 40  CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96
           C     DG   V+AS+  TV   +K S   +H  C                   H   +T
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 153

Query: 97  CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156
            +D    G    ++  D T+K+W      L +  + H   VN   F PSG  +++   D+
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213

Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
            LKI    +   + T  GH+G     A    G    S   D    +W
Sbjct: 214 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 21/75 (28%), Positives = 35/75 (46%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           ++H+ ++  L     G   +++S+D T+KI     G L   L GH        F  +G  
Sbjct: 188 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247

Query: 149 VLSGGMDAQLKIWSA 163
             SGG D Q+ +W +
Sbjct: 248 FASGGSDEQVMVWKS 262



 Score = 36.2 bits (82), Expect = 0.052
 Identities = 17/50 (34%), Positives = 23/50 (46%)

Query: 154 MDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
           MD+ L +W  +  S    F GHK  +        G  + S SRD T R+W
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 38/155 (24%), Positives = 69/155 (44%)

Query: 85  TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144
           +T  R HT ++  +   S G   V++S D T+K+W     +    L  H+  V C +F P
Sbjct: 96  STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            G +++S   D  +K+W      CV ++  H G +        G  + +A  D T ++WD
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239
                 L       +++NG++   + N +   S +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 250



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 27/226 (11%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++TC+D S       S S D  + +W            GH   V C  F PSG ++ 
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  ++IW          F+ H   +        G++ V+AS D T ++W   R   
Sbjct: 78  SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270
           L  L+     IN V                     +   + ++++ A +DK ++     S
Sbjct: 138 LFSLS---QHINWVRCA------------------KFSPDGRLIVSASDDKTVKLWDKSS 176

Query: 271 RQLVFLFIGSDAFNCCTFL----SGFLLLAGTQDGNIYQLDVRSPR 312
           R+ V  +     F   T++    SG  + A   D  +   DVR+ R
Sbjct: 177 RECVHSYCEHGGF--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 32/114 (28%), Positives = 51/114 (44%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   + C   S  G L VS+S D T+K+W  S+ E       H   V    F PSG  + 
Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 203

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           + GMD  +K+W       +  ++ H   +   +    G  +++AS D T ++ D
Sbjct: 204 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%)

Query: 40  CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96
           C     DG   V+AS+  TV   +K S   +H  C                   H   +T
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 191

Query: 97  CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156
            +D    G    ++  D T+K+W      L +  + H   VN   F PSG  +++   D+
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251

Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
            LKI    +   + T  GH+G     A    G    S   D    +W
Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 27/83 (32%), Positives = 37/83 (44%)

Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180
           A +  L R  +GH   V C  F  +   + SG MD+ L +W  +  S    F GHK  + 
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 181 DTAIVDRGRNVVSASRDGTARLW 203
                  G  + S SRD T R+W
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIW 88



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 21/75 (28%), Positives = 35/75 (46%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           ++H+ ++  L     G   +++S+D T+KI     G L   L GH        F  +G  
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 149 VLSGGMDAQLKIWSA 163
             SGG D Q+ +W +
Sbjct: 286 FASGGSDEQVMVWKS 300


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 38/155 (24%), Positives = 69/155 (44%)

Query: 85  TTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP 144
           +T  R HT ++  +   S G   V++S D T+K+W     +    L  H+  V C +F P
Sbjct: 96  STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
            G +++S   D  +K+W      CV ++  H G +        G  + +A  D T ++WD
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 205 CGRSACLGVLADCGSSINGVAVGAADNSINLGSPE 239
                 L       +++NG++   + N +   S +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD 250



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 27/226 (11%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++TC+D S       S S D  + +W            GH   V C  F PSG ++ 
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           SG  D  ++IW          F+ H   +        G++ V+AS D T ++W   R   
Sbjct: 78  SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQS 270
           L  L+     IN V                     +   + ++++ A +DK ++     S
Sbjct: 138 LFSLS---QHINWVRCA------------------KFSPDGRLIVSASDDKTVKLWDKSS 176

Query: 271 RQLVFLFIGSDAFNCCTFL----SGFLLLAGTQDGNIYQLDVRSPR 312
           R+ V  +     F   T++    SG  + A   D  +   DVR+ R
Sbjct: 177 RECVHSYCEHGGF--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 32/114 (28%), Positives = 51/114 (44%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   + C   S  G L VS+S D T+K+W  S+ E       H   V    F PSG  + 
Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 203

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           + GMD  +K+W       +  ++ H   +   +    G  +++AS D T ++ D
Sbjct: 204 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 41/167 (24%), Positives = 61/167 (36%), Gaps = 21/167 (12%)

Query: 40  CQGIGLDGIPEVTASEGFTVNEINKKS---IHISCPKENASSKFLAPYTTFSRIHTKSIT 96
           C     DG   V+AS+  TV   +K S   +H  C                   H   +T
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE------------------HGGFVT 191

Query: 97  CLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDA 156
            +D    G    ++  D T+K+W      L +  + H   VN   F PSG  +++   D+
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251

Query: 157 QLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLW 203
            LKI    +   + T  GH+G     A    G    S   D    +W
Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 27/83 (32%), Positives = 37/83 (44%)

Query: 121 ASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180
           A +  L R  +GH   V C  F  +   + SG MD+ L +W  +  S    F GHK  + 
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 181 DTAIVDRGRNVVSASRDGTARLW 203
                  G  + S SRD T R+W
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIW 88



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 21/75 (28%), Positives = 35/75 (46%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           ++H+ ++  L     G   +++S+D T+KI     G L   L GH        F  +G  
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 149 VLSGGMDAQLKIWSA 163
             SGG D Q+ +W +
Sbjct: 286 FASGGSDEQVMVWKS 300


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 56/236 (23%), Positives = 95/236 (40%), Gaps = 4/236 (1%)

Query: 44  GLDGIPEVTASEGFTVNEINKKSIHISCPKENASSK--FLAPYTTFSRI--HTKSITCLD 99
           G    P+ TA     +   N K+  +   K     K  +  P+  +  I  H   + C+ 
Sbjct: 152 GASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIA 211

Query: 100 ISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLK 159
           +       V+ S D T+KIW  ++G+L+  L GH+  V           + S G D Q+K
Sbjct: 212 VEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVK 271

Query: 160 IWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGS 219
            W  E    +  + GH   +    +      +V+ SRD TAR+WD    A +  L+   +
Sbjct: 272 CWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 331

Query: 220 SINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVF 275
           ++  V   AA+  I  GS +      ++      + L    K ++ + L  R   F
Sbjct: 332 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTF 387



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/151 (21%), Positives = 59/151 (39%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  ++  + +S+R     S   D  +K W     ++ R   GH+  V      P+  V++
Sbjct: 245 HISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLV 304

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSAC 210
           +   D+  +IW     + V T  GH   +           +++ S D T RLWD      
Sbjct: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364

Query: 211 LGVLADCGSSINGVAVGAADNSINLGSPEQM 241
              L +   S+  V +     +   GSP+ +
Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPDNI 395



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 2/114 (1%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT ++  +   +     ++ S D T+++W    G+ R  L  H   V      P      
Sbjct: 329 HTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFA 388

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           SG  D  +K W   D S +    GH   I++T  V+    +VS + +GT  LWD
Sbjct: 389 SGSPD-NIKQWKFPDGSFIQNLSGHNA-IINTLTVNSDGVLVSGADNGTMHLWD 440


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 38/150 (25%), Positives = 68/150 (45%), Gaps = 1/150 (0%)

Query: 93  KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152
           K I  +  S  G    S + DG + I+  + G+L   LEGH   +    F P   ++++ 
Sbjct: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208

Query: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLG 212
             D  +KI+  + A+   T  GH   +L+ A      + VS+S D + ++WD G   C+ 
Sbjct: 209 SDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVH 268

Query: 213 VLADCGSSINGVAV-GAADNSINLGSPEQM 241
              D    + GV   G     +++G  +++
Sbjct: 269 TFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 33/115 (28%), Positives = 47/115 (40%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   I  L  S    L V++S DG +KI+   +  L   L GH   V    F P     +
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
           S   D  +K+W     +CV TF  H+  +        G  +VS   D    ++DC
Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 41/201 (20%), Positives = 70/201 (34%), Gaps = 42/201 (20%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEG------------------ 132
           H   +  +DIS    +  SSS D  +++W   NG+  + ++                   
Sbjct: 63  HQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLA 122

Query: 133 ---HVFDVN---------------------CCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
              HV  VN                        + P G  + SG +D  + I+       
Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL 182

Query: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228
           + T +GH   I         + +V+AS DG  +++D   +   G L+   S +  VA   
Sbjct: 183 LHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCP 242

Query: 229 ADNSINLGSPEQMPSEREVGT 249
            D      S ++     +VGT
Sbjct: 243 DDTHFVSSSSDKSVKVWDVGT 263



 Score = 31.2 bits (69), Expect = 1.7
 Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 149 VLSGGMDAQLKIWSAEDASCVV--TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           V++G +D  +K+W   D    +  + +GH+ G++   I        S+S D   RLWD
Sbjct: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 17/187 (9%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  ++C        + V+SS D T  +W    G+ + V  GH  D       P   + +
Sbjct: 142 HTGYLSCCRFLDDNNI-VTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFI 200

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC----- 205
           SG  DA  K+W   + +C  TF GH+  I        G  + + S D + RL+D      
Sbjct: 201 SGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQE 260

Query: 206 ----GRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDK 261
                  + +  +     S++G  + A  +  N    + M SER VG      +L+  D 
Sbjct: 261 LICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSER-VG------ILSGHDN 313

Query: 262 KLQCLGL 268
           ++ CLG+
Sbjct: 314 RVSCLGV 320



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 60/225 (26%), Positives = 89/225 (39%), Gaps = 21/225 (9%)

Query: 123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDT 182
           N ++ R L  H   ++CCRF     +V S G D    +W  E       F GH G  +  
Sbjct: 132 NVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSL 190

Query: 183 AIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMP 242
           A+       +S + D +A+LWD     C        S IN +       +I  GS +   
Sbjct: 191 AVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDD--- 247

Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGN 302
                   +  L   R D++L C    S + +   I S AF+    LSG LL AG  D N
Sbjct: 248 -------ASCRLFDLRADQELICF---SHESIICGITSVAFS----LSGRLLFAGYDDFN 293

Query: 303 IYQLD-VRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFI 346
               D ++S R  +   H +    L + +  DG   + G    F+
Sbjct: 294 CNVWDSMKSERVGILSGHDNRVSCLGVTA--DGMAVATGSWDSFL 336



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 21/68 (30%), Positives = 31/68 (45%)

Query: 95  ITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGM 154
           IT +  S  G L  +   D    +W +   E   +L GH   V+C      G+ V +G  
Sbjct: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSW 332

Query: 155 DAQLKIWS 162
           D+ LKIW+
Sbjct: 333 DSFLKIWN 340


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 37/114 (32%), Positives = 55/114 (48%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H   + C+DIS  G L  + S D  +KIW    G+  + L  H   V   +F P   +  
Sbjct: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           + G D ++K W A+    + T +GH   I   A+   G  VVS+S D + RLW+
Sbjct: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 27/114 (23%), Positives = 48/114 (42%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           H  +IT L     GG   S S D  + +W   N      L+GH   +    F     +++
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           + G D  +K W  +   C  T  GH+  +    ++   + +++ + D   R+WD
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 30/147 (20%), Positives = 61/147 (41%)

Query: 93  KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152
           + +TCL  S  G        DG+++I+   +GE      GH   +   ++   G  + SG
Sbjct: 66  QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125

Query: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLG 212
             D  + +W   + S +   KGHK  I     +     +V++ +D   + WD     C  
Sbjct: 126 SKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFK 185

Query: 213 VLADCGSSINGVAVGAADNSINLGSPE 239
            +    + + G+ + + +  +  G+ +
Sbjct: 186 TMVGHRTEVWGLVLLSEEKRLITGASD 212



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 47/202 (23%), Positives = 80/202 (39%), Gaps = 14/202 (6%)

Query: 74  ENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGH 133
           EN++ K L+   T +    + + C+  S    L   S  D T+KI+     +    L GH
Sbjct: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590

Query: 134 VFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVS 193
              V C      G ++ +G  D  +KIW  +   C  +   H   ++    V +     +
Sbjct: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFT 650

Query: 194 ASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAA---------DNSINLGSPEQMP-- 242
           A +D   + WD  +   +  L      I  +AV  +         D S+ L    + P  
Sbjct: 651 AGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLI 710

Query: 243 --SEREVGTEAKM-LLLAREDK 261
              ERE+  EA+    +A+ED+
Sbjct: 711 LEEEREMEREAEYEESVAKEDQ 732



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 28/87 (32%), Positives = 38/87 (43%)

Query: 118 IWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKG 177
           IW    GE   +L+G   +V C    P GL +  G  D  ++I+S       VTF GHK 
Sbjct: 49  IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108

Query: 178 GILDTAIVDRGRNVVSASRDGTARLWD 204
            I        G  + S S+D    +WD
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWD 135



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 26/115 (22%), Positives = 47/115 (40%), Gaps = 5/115 (4%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFF-PSGLVV 149
           H   +  L  SS   + V S+   ++KIW  S  +  R +     +   C FF P    V
Sbjct: 414 HRSDVRTLSFSS-DNIAVLSAAADSIKIWNRSTLQCIRTM---TCEYALCSFFVPGDRQV 469

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           + G    +L+++     + + T   H G +   ++    R  V+   D + + WD
Sbjct: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 12/127 (9%)

Query: 127 RRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVD 186
           R  + GH  DV    F    + VLS   D+ +KIW+     C+ T        L +  V 
Sbjct: 408 RITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYA--LCSFFVP 464

Query: 187 RGRNVVSASRDGTARLWDCGRSACLGVLADCGSSI---------NGVAVGAADNSINLGS 237
             R VV  ++ G  +L+D      L  +     ++          G   G AD S+    
Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524

Query: 238 PEQMPSE 244
            E +  E
Sbjct: 525 FELVKDE 531


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 32/114 (28%), Positives = 55/114 (48%)

Query: 91  HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
           HT  +  + +++   L V+ S  G++++W     ++ R L GH  ++    F P G  V 
Sbjct: 62  HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121

Query: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           SG  D  +K+W      CV  ++GH   +        G+ + SA+ D T +LWD
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 11/154 (7%)

Query: 89  RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLV 148
           R H++++ CL  S  G    S++ D T+K+W  + G++     GH   VN   F P+  +
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203

Query: 149 VLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRS 208
           + SG  D  ++ W  E    V   +G  G +        G  + S  +D + R++     
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPE 262

Query: 209 ACLGV----------LADCGSSINGVAVGAADNS 232
            C  V          LA C   + GVA   ++ S
Sbjct: 263 RCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVS 296



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 1/122 (0%)

Query: 91  HTKSITCLDISSRGG-LGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVV 149
           H  +++ L +    G L  +   D  + +W  +       L GH   V   R      ++
Sbjct: 19  HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78

Query: 150 LSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 209
           ++G     +++W  E A  + T  GHK  I        G  V S S+D   +LWD  R  
Sbjct: 79  VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138

Query: 210 CL 211
           C+
Sbjct: 139 CV 140



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 50/214 (23%), Positives = 90/214 (42%), Gaps = 26/214 (12%)

Query: 145 SGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
           SG ++ +GG D ++ +WS    +C+++  GH   +    +      +V+ S+ G+ R+WD
Sbjct: 32  SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91

Query: 205 CGRSACLGVLADCGSSI---------NGVAVGAADNSINL-------------GSPEQMP 242
              +  L  L    ++I           VA G+ D +I L             G  + + 
Sbjct: 92  LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151

Query: 243 SEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTF-LSGFLLLAGTQD 300
             R    + K L  A +D  ++   L + +++  F G +   N   F  + +LL +G+ D
Sbjct: 152 CLR-FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210

Query: 301 GNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDG 334
             I   D+   +  V  I     PV S+L   DG
Sbjct: 211 RTIRFWDLEKFQV-VSCIEGEPGPVRSVLFNPDG 243


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,411,773
Number of Sequences: 37866
Number of extensions: 678302
Number of successful extensions: 3131
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 1610
Number of HSP's gapped (non-prelim): 1129
length of query: 392
length of database: 18,247,518
effective HSP length: 104
effective length of query: 288
effective length of database: 14,309,454
effective search space: 4121122752
effective search space used: 4121122752
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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