Search of human proteins with 13376349

Search of human proteins with 13376349

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13376349 PDZ domain containing 7 [Homo sapiens]
         (517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13376349 PDZ domain containing 7 [Homo sapiens]                   1029   0.0  
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi...   167   3e-41
gi|41281808 harmonin isoform b3 [Homo sapiens]                        108   2e-23
gi|71480164 harmonin isoform a [Homo sapiens]                         108   2e-23
gi|45827729 scribble isoform b [Homo sapiens]                          77   3e-14
gi|45827731 scribble isoform a [Homo sapiens]                          77   3e-14
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan...    73   7e-13
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     73   7e-13
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    71   3e-12
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    71   3e-12
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa...    70   4e-12
gi|7706025 PDZ domain containing 11 [Homo sapiens]                     70   5e-12
gi|148746189 multiple PDZ domain protein [Homo sapiens]                69   8e-12
gi|112382257 InaD-like [Homo sapiens]                                  68   2e-11
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      68   2e-11
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    67   5e-11
gi|11545920 lin-7 homolog B [Homo sapiens]                             65   2e-10
gi|8922944 lin-7 homolog C [Homo sapiens]                              64   3e-10
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      62   1e-09
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       62   1e-09
gi|4759306 lin-7 homolog A [Homo sapiens]                              62   1e-09
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       62   1e-09
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       62   1e-09
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|21361142 PDZ domain containing 1 [Homo sapiens]                     62   2e-09
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    61   2e-09
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...    59   1e-08
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...    59   1e-08

>gi|13376349 PDZ domain containing 7 [Homo sapiens]
          Length = 517

 Score = 1029 bits (2661), Expect = 0.0
 Identities = 517/517 (100%), Positives = 517/517 (100%)

Query: 1   MAQGFAVGFDPLGLGDLSSGSLSSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRA 60
           MAQGFAVGFDPLGLGDLSSGSLSSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRA
Sbjct: 1   MAQGFAVGFDPLGLGDLSSGSLSSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRA 60

Query: 61  SSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGS 120
           SSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGS
Sbjct: 61  SSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGS 120

Query: 121 SAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT 180
           SAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT
Sbjct: 121 SAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT 180

Query: 181 WVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSK 240
           WVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSK
Sbjct: 181 WVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSK 240

Query: 241 VDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEM 300
           VDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEM
Sbjct: 241 VDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEM 300

Query: 301 VSEYCWLDRLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRG 360
           VSEYCWLDRLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRG
Sbjct: 301 VSEYCWLDRLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRG 360

Query: 361 PGWGRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTAL 420
           PGWGRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTAL
Sbjct: 361 PGWGRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTAL 420

Query: 421 LLALSRPRPPITRSQSYLTLWEEKQQRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRL 480
           LLALSRPRPPITRSQSYLTLWEEKQQRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRL
Sbjct: 421 LLALSRPRPPITRSQSYLTLWEEKQQRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRL 480

Query: 481 ARDGRREAWTLDSGSLAKTYPRLDIEKEMGVSPCCPG 517
           ARDGRREAWTLDSGSLAKTYPRLDIEKEMGVSPCCPG
Sbjct: 481 ARDGRREAWTLDSGSLAKTYPRLDIEKEMGVSPCCPG 517


>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
           sapiens]
          Length = 907

 Score =  167 bits (422), Expect = 3e-41
 Identities = 102/235 (43%), Positives = 134/235 (57%), Gaps = 14/235 (5%)

Query: 86  SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTT 145
           S+R  K+  G LGFS+RGGSEHG+GI+VS VE GS AE+ GL VGD+I  VN  SL   T
Sbjct: 142 SLRRAKAHEG-LGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVT 200

Query: 146 MGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTS--S 203
              AVK L  S +L + V   GR+PG   +    TWVD   R +        P   +   
Sbjct: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260

Query: 204 EDGVRR-IVHLYTTSDDF----------CLGFNIRGGKEFGLGIYVSKVDHGGLAEENGI 252
           ++G RR  +HL    D+            LG  IRGG E+GLGIY++ VD G  AE +G+
Sbjct: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGL 320

Query: 253 KVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWL 307
           KVGDQ+L  NG  F +I H +AV +LK   H++LT+K+ GR P  +  V E  W+
Sbjct: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWI 375



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 44/107 (41%), Positives = 63/107 (58%)

Query: 202 SSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAA 261
           S+  G  R+V L        LGF+IRGG E G+GIYVS V+ G LAE+ G++VGDQ+L  
Sbjct: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRV 191

Query: 262 NGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLD 308
           N      ++H++AV+ LKG   ++L++   GR P        Y W+D
Sbjct: 192 NDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVD 238



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 3/72 (4%)

Query: 87  VRVEKSPAGRLGFSVRGGSEHGLGI-FVSKVEEGSSAERAG-LCVGDKITEVNGLSLEST 144
           VRV+KS A  LG ++ GG+     +  +  ++ G SA   G L VG  I EVNGL+L   
Sbjct: 817 VRVKKS-AATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGK 875

Query: 145 TMGSAVKVLTSS 156
               A +++  +
Sbjct: 876 EHREAARIIAEA 887


>gi|41281808 harmonin isoform b3 [Homo sapiens]
          Length = 899

 Score =  108 bits (269), Expect = 2e-23
 Identities = 68/208 (32%), Positives = 109/208 (52%), Gaps = 7/208 (3%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES 143
           +  VR+++     LG SVRGG E G G+F+S + +G  A+  GL VGD+I  +NG S+ S
Sbjct: 85  LKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISS 144

Query: 144 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEK---CGSTPSD 200
            T    + ++ +   + + VR +G +P      E  TW  V   + V E     GS  S 
Sbjct: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYV--DQFVSESGGVRGSLGSP 202

Query: 201 TSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLA 260
            + E+  +++      S    LG +I  G     GI++S V  G L+ E G+++GDQ++ 
Sbjct: 203 GNRENKEKKVFISLVGSRG--LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVE 260

Query: 261 ANGVRFDDISHSQAVEVLKGQTHIMLTI 288
            NGV F ++ H +AV VLK    + ++I
Sbjct: 261 VNGVDFSNLDHKEAVNVLKSSRSLTISI 288



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 41/150 (27%), Positives = 71/150 (47%), Gaps = 15/150 (10%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
           LG ++RGG EFG G+++S +  GG A+  G++VGD+++  NG      +H + + +++ +
Sbjct: 98  LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTK 157

Query: 282 THIMLTIKETGRYPAYKEMVSEYCW--LDRL---SNGVLQQL-SPASESS-------SSV 328
             + + ++  G  P          W  +D+    S GV   L SP +  +       S V
Sbjct: 158 KTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLV 217

Query: 329 SSCASSAPYSSGSLPSDRMDICLGQEEPGS 358
            S       SSG  P  +  I +   +PGS
Sbjct: 218 GSRGLGCSISSG--PIQKPGIFISHVKPGS 245



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLG-IFVSKVEEGSSAER-AGLCVGDKITEVNGLSL 141
           +  +R++K   G L  ++ GG +  +G + VS V E  +AER  G+  GD+I  +NG  +
Sbjct: 753 VRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 810

Query: 142 ESTTMGSAVKVL 153
              T+  A   L
Sbjct: 811 TDYTLAEAEAAL 822



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 197 TPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLG-IYVSKVDHGGLAEENG-IKV 254
           TP     +D     V L     +  L   + GG +  +G + VS V   G AE +G I  
Sbjct: 744 TPEQIMGKD-----VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 798

Query: 255 GDQVLAANGVRFDDISHSQAVEVLK 279
           GD+++A NG    D + ++A   L+
Sbjct: 799 GDEIMAINGKIVTDYTLAEAEAALQ 823


>gi|71480164 harmonin isoform a [Homo sapiens]
          Length = 552

 Score =  108 bits (269), Expect = 2e-23
 Identities = 68/208 (32%), Positives = 109/208 (52%), Gaps = 7/208 (3%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES 143
           +  VR+++     LG SVRGG E G G+F+S + +G  A+  GL VGD+I  +NG S+ S
Sbjct: 85  LKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISS 144

Query: 144 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEK---CGSTPSD 200
            T    + ++ +   + + VR +G +P      E  TW  V   + V E     GS  S 
Sbjct: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYV--DQFVSESGGVRGSLGSP 202

Query: 201 TSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLA 260
            + E+  +++      S    LG +I  G     GI++S V  G L+ E G+++GDQ++ 
Sbjct: 203 GNRENKEKKVFISLVGSRG--LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVE 260

Query: 261 ANGVRFDDISHSQAVEVLKGQTHIMLTI 288
            NGV F ++ H +AV VLK    + ++I
Sbjct: 261 VNGVDFSNLDHKEAVNVLKSSRSLTISI 288



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 41/150 (27%), Positives = 71/150 (47%), Gaps = 15/150 (10%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
           LG ++RGG EFG G+++S +  GG A+  G++VGD+++  NG      +H + + +++ +
Sbjct: 98  LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTK 157

Query: 282 THIMLTIKETGRYPAYKEMVSEYCW--LDRL---SNGVLQQL-SPASESS-------SSV 328
             + + ++  G  P          W  +D+    S GV   L SP +  +       S V
Sbjct: 158 KTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLV 217

Query: 329 SSCASSAPYSSGSLPSDRMDICLGQEEPGS 358
            S       SSG  P  +  I +   +PGS
Sbjct: 218 GSRGLGCSISSG--PIQKPGIFISHVKPGS 245



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLG-IFVSKVEEGSSAER-AGLCVGDKITEVNGLSL 141
           +  +R++K   G L  ++ GG +  +G + VS V E  +AER  G+  GD+I  +NG  +
Sbjct: 453 VRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 510

Query: 142 ESTTMGSAVKVL 153
              T+  A   L
Sbjct: 511 TDYTLAEAEAAL 522



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 197 TPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLG-IYVSKVDHGGLAEENG-IKV 254
           TP     +D     V L     +  L   + GG +  +G + VS V   G AE +G I  
Sbjct: 444 TPEQIMGKD-----VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 498

Query: 255 GDQVLAANGVRFDDISHSQAVEVLK 279
           GD+++A NG    D + ++A   L+
Sbjct: 499 GDEIMAINGKIVTDYTLAEAEAALQ 523


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 70/242 (28%), Positives = 113/242 (46%), Gaps = 27/242 (11%)

Query: 85   HSVRVEKSPAGRLGFSVRGGSEH------GLGIFVSKVEEGSSAERAG-LCVGDKITEVN 137
            H   + +S  G LGFS+ GG           GIFVS++ EG +A RAG L VGD++  +N
Sbjct: 861  HVACLARSERG-LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 138  GLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVP----GIKFSKEKTTWVDVVNRRLVVE 192
            G+ +       AV +LT++S  + +++ R    P     +  S   T  V   +      
Sbjct: 920  GVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATP 979

Query: 193  KCGSTPSDTSS-----EDGVRRIVHLYTTSDDFCLGFNIRGGKE-----FGL---GIYVS 239
                 PS   S      +G   +  +        LG +I GG +     FG+   G+++S
Sbjct: 980  GVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFIS 1039

Query: 240  KVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVE-VLKGQTHIMLTIKETGRYPAYK 298
            KV   GLA  +G++VGD++LA NG    D +H +AV  +L+    + L ++     P  +
Sbjct: 1040 KVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR 1099

Query: 299  EM 300
            E+
Sbjct: 1100 EL 1101



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 72/219 (32%), Positives = 102/219 (46%), Gaps = 24/219 (10%)

Query: 95  GRLGFSVRGGSEH------GLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGS 148
           G LG S+ GG           GIF+S+V E   A RAG+ VGDK+ EVNG++L+      
Sbjct: 736 GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795

Query: 149 AVKVLT-SSSRLHMMVRRMGRV-PGIKFSKEKTTWVDVVNRRLVVEKCGS---TPSDTSS 203
           AV+ L  + + + M V R   V P    +       D  + R   E+ G     P     
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR---ERRGGGLRLPLLPPE 852

Query: 204 EDGVRRIVHLYTTS-DDFCLGFNIRGGK------EFGLGIYVSKVDHGGLAEENG-IKVG 255
             G  R  H+   +  +  LGF+I GGK          GI+VS++  GG A   G ++VG
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912

Query: 256 DQVLAANGVRFDDISHSQAVEVL--KGQTHIMLTIKETG 292
           D+VL+ NGV   +  H  AV +L     T  +L  +E G
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG 951



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 61/215 (28%), Positives = 94/215 (43%), Gaps = 57/215 (26%)

Query: 84   IHSVRVEKSPAGRLGFSVRGGSEHGL--------GIFVSKVEEGSSAERAGLCVGDKITE 135
            +  +R+ ++  G LG S+ GGS+H          G+F+SKV     A R+GL VGD+I  
Sbjct: 1002 VEEIRLPRA-GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060

Query: 136  VNGLSLESTTMGSAVK-VLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKC 194
            VNG  +   T   AV  +L     L ++VRR    PG+              R L ++K 
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGL--------------RELCIQK- 1105

Query: 195  GSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKE---------FGLGIYVSKVDHGG 245
               P +                     LG +IRGG              GI++SKV   G
Sbjct: 1106 --APGER--------------------LGISIRGGARGHAGNPRDPTDEGIFISKVSPTG 1143

Query: 246  LAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
             A  +G ++VG ++L  N      ++H +AV++L+
Sbjct: 1144 AAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 70/242 (28%), Positives = 113/242 (46%), Gaps = 27/242 (11%)

Query: 85   HSVRVEKSPAGRLGFSVRGGSEH------GLGIFVSKVEEGSSAERAG-LCVGDKITEVN 137
            H   + +S  G LGFS+ GG           GIFVS++ EG +A RAG L VGD++  +N
Sbjct: 861  HVACLARSERG-LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 138  GLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVP----GIKFSKEKTTWVDVVNRRLVVE 192
            G+ +       AV +LT++S  + +++ R    P     +  S   T  V   +      
Sbjct: 920  GVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATP 979

Query: 193  KCGSTPSDTSS-----EDGVRRIVHLYTTSDDFCLGFNIRGGKE-----FGL---GIYVS 239
                 PS   S      +G   +  +        LG +I GG +     FG+   G+++S
Sbjct: 980  GVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFIS 1039

Query: 240  KVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVE-VLKGQTHIMLTIKETGRYPAYK 298
            KV   GLA  +G++VGD++LA NG    D +H +AV  +L+    + L ++     P  +
Sbjct: 1040 KVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR 1099

Query: 299  EM 300
            E+
Sbjct: 1100 EL 1101



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 72/219 (32%), Positives = 102/219 (46%), Gaps = 24/219 (10%)

Query: 95  GRLGFSVRGGSEH------GLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGS 148
           G LG S+ GG           GIF+S+V E   A RAG+ VGDK+ EVNG++L+      
Sbjct: 736 GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795

Query: 149 AVKVLT-SSSRLHMMVRRMGRV-PGIKFSKEKTTWVDVVNRRLVVEKCGS---TPSDTSS 203
           AV+ L  + + + M V R   V P    +       D  + R   E+ G     P     
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR---ERRGGGLRLPLLPPE 852

Query: 204 EDGVRRIVHLYTTS-DDFCLGFNIRGGK------EFGLGIYVSKVDHGGLAEENG-IKVG 255
             G  R  H+   +  +  LGF+I GGK          GI+VS++  GG A   G ++VG
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912

Query: 256 DQVLAANGVRFDDISHSQAVEVL--KGQTHIMLTIKETG 292
           D+VL+ NGV   +  H  AV +L     T  +L  +E G
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG 951



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 61/215 (28%), Positives = 94/215 (43%), Gaps = 57/215 (26%)

Query: 84   IHSVRVEKSPAGRLGFSVRGGSEHGL--------GIFVSKVEEGSSAERAGLCVGDKITE 135
            +  +R+ ++  G LG S+ GGS+H          G+F+SKV     A R+GL VGD+I  
Sbjct: 1002 VEEIRLPRA-GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060

Query: 136  VNGLSLESTTMGSAVK-VLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKC 194
            VNG  +   T   AV  +L     L ++VRR    PG+              R L ++K 
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGL--------------RELCIQK- 1105

Query: 195  GSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKE---------FGLGIYVSKVDHGG 245
               P +                     LG +IRGG              GI++SKV   G
Sbjct: 1106 --APGER--------------------LGISIRGGARGHAGNPRDPTDEGIFISKVSPTG 1143

Query: 246  LAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
             A  +G ++VG ++L  N      ++H +AV++L+
Sbjct: 1144 AAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178


>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
           factor 2, partial [Homo sapiens]
          Length = 803

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 36/82 (43%), Positives = 52/82 (63%)

Query: 208 RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFD 267
           RR++ L   S +  L F + GG E G GI+V  VD G  A E G+K GDQ+L  NG  F+
Sbjct: 383 RRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFE 442

Query: 268 DISHSQAVEVLKGQTHIMLTIK 289
           +I  S+A+E+L+  TH+ +T+K
Sbjct: 443 NIQLSKAMEILRNNTHLSITVK 464



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 30/68 (44%), Positives = 44/68 (64%)

Query: 97  LGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSS 156
           L F + GGSE G GIFV  V+ GS A  AGL  GD+I EVNG + E+  +  A+++L ++
Sbjct: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456

Query: 157 SRLHMMVR 164
           + L + V+
Sbjct: 457 THLSITVK 464


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 36/82 (43%), Positives = 52/82 (63%)

Query: 208 RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFD 267
           RR++ L   S +  L F + GG E G GI+V  VD G  A E G+K GDQ+L  NG  F+
Sbjct: 383 RRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFE 442

Query: 268 DISHSQAVEVLKGQTHIMLTIK 289
           +I  S+A+E+L+  TH+ +T+K
Sbjct: 443 NIQLSKAMEILRNNTHLSITVK 464



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 30/68 (44%), Positives = 44/68 (64%)

Query: 97  LGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSS 156
           L F + GGSE G GIFV  V+ GS A  AGL  GD+I EVNG + E+  +  A+++L ++
Sbjct: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456

Query: 157 SRLHMMVR 164
           + L + V+
Sbjct: 457 THLSITVK 464


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 72/255 (28%), Positives = 123/255 (48%), Gaps = 41/255 (16%)

Query: 84  IHSVRVEKSPAGRLGFSVRGG--SEHGLG---IFVSKVEEGSSAERAG-LCVGDKITEVN 137
           +  +++ K P G LGFS+ GG  ++H  G   I+V+K+ EG +A + G L +GDKI  VN
Sbjct: 201 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259

Query: 138 GLSLESTTMGSAVKVLTSS-SRLHMMVRRMGRV--------PGIKFSKEKTTWVDVVNRR 188
            + LE      AV  L ++   +++ V +            P I  S  +    ++ +  
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSS 319

Query: 189 LVVEKCGSTPSDTS------------SEDGVRR-----IVHLYTTSDDFCLGFNIRGGKE 231
            +     +  + TS             E+ + R     ++H  +T     LGFNI GG++
Sbjct: 320 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTG----LGFNIVGGED 375

Query: 232 FGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK--GQTHIMLTI 288
            G GI++S +  GG A+ +G ++ GDQ+L+ NGV   + SH QA   LK  GQT  ++  
Sbjct: 376 -GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434

Query: 289 KETGRYPAYKEMVSE 303
            +   Y  ++  + +
Sbjct: 435 YKPEEYSRFEAKIHD 449



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 29/85 (34%), Positives = 45/85 (52%), Gaps = 6/85 (7%)

Query: 222 LGFNIRGGKEF-----GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAV 275
           LGF+I GG +         I+++K+  GG A ++G ++V D +L  N V   +++HS AV
Sbjct: 118 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 177

Query: 276 EVLKGQTHIMLTIKETGRYPAYKEM 300
           E LK    I+       + PA K M
Sbjct: 178 EALKEAGSIVRLYVMRRKPPAEKVM 202


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 72/255 (28%), Positives = 123/255 (48%), Gaps = 41/255 (16%)

Query: 84  IHSVRVEKSPAGRLGFSVRGG--SEHGLG---IFVSKVEEGSSAERAG-LCVGDKITEVN 137
           +  +++ K P G LGFS+ GG  ++H  G   I+V+K+ EG +A + G L +GDKI  VN
Sbjct: 155 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213

Query: 138 GLSLESTTMGSAVKVLTSS-SRLHMMVRRMGRV--------PGIKFSKEKTTWVDVVNRR 188
            + LE      AV  L ++   +++ V +            P I  S  +    ++ +  
Sbjct: 214 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSS 273

Query: 189 LVVEKCGSTPSDTS------------SEDGVRR-----IVHLYTTSDDFCLGFNIRGGKE 231
            +     +  + TS             E+ + R     ++H  +T     LGFNI GG++
Sbjct: 274 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTG----LGFNIVGGED 329

Query: 232 FGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK--GQTHIMLTI 288
            G GI++S +  GG A+ +G ++ GDQ+L+ NGV   + SH QA   LK  GQT  ++  
Sbjct: 330 -GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388

Query: 289 KETGRYPAYKEMVSE 303
            +   Y  ++  + +
Sbjct: 389 YKPEEYSRFEAKIHD 403



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 29/85 (34%), Positives = 45/85 (52%), Gaps = 6/85 (7%)

Query: 222 LGFNIRGGKEF-----GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAV 275
           LGF+I GG +         I+++K+  GG A ++G ++V D +L  N V   +++HS AV
Sbjct: 72  LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 131

Query: 276 EVLKGQTHIMLTIKETGRYPAYKEM 300
           E LK    I+       + PA K M
Sbjct: 132 EALKEAGSIVRLYVMRRKPPAEKVM 156


>gi|54633319 PDZ domain-containing guanine nucleotide exchange
           factor I [Homo sapiens]
          Length = 1601

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 34/81 (41%), Positives = 52/81 (64%)

Query: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDD 268
           R V L   S +  L F++ GG E G GI+V  V+ G  A ++G+K GDQ++  NG  F++
Sbjct: 529 RQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFEN 588

Query: 269 ISHSQAVEVLKGQTHIMLTIK 289
           I+  +AVE+L+  TH+ LT+K
Sbjct: 589 ITFMKAVEILRNNTHLALTVK 609



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 41/116 (35%), Positives = 62/116 (53%), Gaps = 3/116 (2%)

Query: 49  RLLNGPPRGIRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHG 108
           R L    + +  +   G + L+N    A +    ++      +SP   L FS+ GGSE G
Sbjct: 497 RFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESP---LQFSLNGGSEKG 553

Query: 109 LGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVR 164
            GIFV  VE GS A  +GL  GD+I EVNG + E+ T   AV++L +++ L + V+
Sbjct: 554 FGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVK 609


>gi|7706025 PDZ domain containing 11 [Homo sapiens]
          Length = 140

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 36/68 (52%), Positives = 45/68 (66%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
           LGFNIRGGK   LGI++SKV     A   G++ GDQVLA N V F DI HS+AVE+LK  
Sbjct: 58  LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117

Query: 282 THIMLTIK 289
             I + ++
Sbjct: 118 REISMRVR 125



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 31/79 (39%), Positives = 48/79 (60%)

Query: 86  SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTT 145
           ++ ++K P  +LGF++RGG    LGIF+SKV   S A RAGL  GD++  VN +  +   
Sbjct: 47  TITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIE 106

Query: 146 MGSAVKVLTSSSRLHMMVR 164
              AV++L ++  + M VR
Sbjct: 107 HSKAVEILKTAREISMRVR 125


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 17/219 (7%)

Query: 71   NSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLG---IFVSKVEE-GSSAERAG 126
            +S   A + E   + +V ++K P   LG S+ GG    LG   IF++ +   G +A+   
Sbjct: 1818 SSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQK 1877

Query: 127  LCVGDKITEVNGLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVPGIKFSKEKTTWVDVV 185
            L VGD+I  + G S E  T   AV +L ++S  + M V   G V  +   +++     + 
Sbjct: 1878 LRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSL- 1936

Query: 186  NRRLVVEKCGSTPSDTSSED-GVRRIVHLYTTSDDFCLGFNIRGG---KEFGLGIYVSKV 241
                     G T S    +D G  +   +        LGF+I GG       L IYV  V
Sbjct: 1937 ------SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTV 1990

Query: 242  DHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
               G A E+G +K GDQ++A NG   + ++H +AV +LK
Sbjct: 1991 FAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 60/198 (30%), Positives = 91/198 (45%), Gaps = 25/198 (12%)

Query: 91  KSPAGRLGFSV---RGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLEST-T 145
           K P+G LGFSV   R  +   LGIFV +++EGS A R G L   D+I  +NG +L+ T T
Sbjct: 142 KPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTIT 201

Query: 146 MGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSED 205
              A+ +L  +     +V   G +P +                 +V +  S  S  S+  
Sbjct: 202 HQQAISILQKAKDTVQLVIARGSLPQLVSP--------------IVSRSPSAASTISAHS 247

Query: 206 GVRRIVHLYT---TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAA 261
                 H+ T    +D   LGF I GGK    G+ V  +  GG+A+++G +  GD +L  
Sbjct: 248 NPVHWQHMETIELVNDGSGLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCSGDHILKI 305

Query: 262 NGVRFDDISHSQAVEVLK 279
                  +S  Q  +VL+
Sbjct: 306 GDTDLAGMSSEQVAQVLR 323



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 26/235 (11%)

Query: 72  SPIEANSDESDIIHSVRVEKSPAGR-LGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCV 129
           S I A+S+     H   +E    G  LGF + GG     G+ V  +  G  A++ G LC 
Sbjct: 241 STISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCS 298

Query: 130 GDKITEVNGLSLESTTMGSAVKVLTS-SSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRR 188
           GD I ++    L   +     +VL    +R+ +M+ R     G    +   T + +    
Sbjct: 299 GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR-----GAIEERTAPTALGIT--- 350

Query: 189 LVVEKCGSTPS---DTSSEDGVR-RIVHLYTTSDDFCLGFNIRG----GKEFGLGIYVSK 240
            +     STP    D S++ G       +  T +   LG  I G     K    GI+V  
Sbjct: 351 -LSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKS 409

Query: 241 VDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK--GQTHIMLTIKETG 292
           +      E +G I++GDQ++A +G      ++ QAVEVL+  GQT ++LT+   G
Sbjct: 410 ITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT-VLLTLMRRG 463



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 53/197 (26%), Positives = 86/197 (43%), Gaps = 35/197 (17%)

Query: 86   SVRVEKSPAGRLGFSVRGGSEHGLG-IFVSKV-EEGSSAERAGLCVGDKITEVNGLSLES 143
            ++ + K   G LG S+ GGS+  LG I + +V EEG++ +   L  GD+I EVNG+ L  
Sbjct: 1629 TIEISKGRTG-LGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRK 1687

Query: 144  TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSS 203
             T   A+ VL  + +   +       P   + +E              E C +   +   
Sbjct: 1688 ATHDEAINVLRQTPQRVRLTLYRDEAP---YKEE--------------EVCDTLTIELQK 1730

Query: 204  EDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAAN 262
            + G               LG +I  GK    G++VS +  GG+A+ +G +  GDQ+L  N
Sbjct: 1731 KPGKG-------------LGLSI-VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVN 1776

Query: 263  GVRFDDISHSQAVEVLK 279
            G    + +      +LK
Sbjct: 1777 GEDVRNATQEAVAALLK 1793



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 23/194 (11%)

Query: 84   IHSVRVEKSPAGRLGFSVRGGSEHG-LGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSL 141
            +H + +EK  +G LG S+ G  +   + +F+  ++   +A + G L + D++ E+NG  L
Sbjct: 1348 LHMIELEKGHSG-LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406

Query: 142  ESTTMGSAVKVLTSS-SRLHMM-------VRRMGRVPGIKFSKEKTTWVDVVNRRLVVEK 193
               +  +A  ++  + S++ ++       V +M   PG       +   ++ N+      
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKE----- 1461

Query: 194  CGSTPSDTSSEDGV-----RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAE 248
              + P+ T+S+  V     + + HL    D   LG  I         I  S  +HG  A 
Sbjct: 1462 --TEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAAT 1519

Query: 249  ENGIKVGDQVLAAN 262
            +  +KVGDQ+LA +
Sbjct: 1520 DGRLKVGDQILAVD 1533



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 53/214 (24%), Positives = 86/214 (40%), Gaps = 33/214 (15%)

Query: 97   LGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTS 155
            LG +V    + GLG+ V  +  G +  R G + +GD I  +N  S  S T   A  +L  
Sbjct: 1018 LGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076

Query: 156  SSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGS-----TPSDTSSEDGVRRI 210
             S +   ++ +  VP     + K +      R + ++   S      P     E+G    
Sbjct: 1077 HSLIGPDIK-ITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEE 1135

Query: 211  VHLYTTS---------------DDFCLGFNIRGGKEFGL---------GIYVSKVDHGGL 246
              L  T+                   LG +I GG+  G          GI++  V     
Sbjct: 1136 SELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSP 1195

Query: 247  AEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
            A +NG +K GD+++  +G+   D SH QAVE ++
Sbjct: 1196 AGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 10/77 (12%)

Query: 87   VRVEKSPAGRLGFSVRGGSEHGL---------GIFVSKVEEGSSAERAG-LCVGDKITEV 136
            V + + P+  LG S+ GG   G          GIF+  V E S A + G L  GD+I EV
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211

Query: 137  NGLSLESTTMGSAVKVL 153
            +G+ L   +   AV+ +
Sbjct: 1212 DGMDLRDASHEQAVEAI 1228



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 2/71 (2%)

Query: 222  LGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
            LG  +   K+ GLG+ V  + HGG    +G I +GD +L+ N      ++++QA  +L+ 
Sbjct: 1018 LGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076

Query: 281  QTHIMLTIKET 291
             + I   IK T
Sbjct: 1077 HSLIGPDIKIT 1087



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 43/194 (22%), Positives = 74/194 (38%), Gaps = 27/194 (13%)

Query: 114 SKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVPGI 172
           S + EG       L  GD++ EVNG++L        V +L      + M+  R    P  
Sbjct: 580 SVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTT 639

Query: 173 KFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNI------ 226
           +   +     D+          G     + +ED V  +     ++++      +      
Sbjct: 640 QSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQ 699

Query: 227 -----RGGKEFGLGI--YVSKVDH------------GGLAEENG-IKVGDQVLAANGVRF 266
                +G K  G  I  Y   +D             GG+AE++G +  GD+++  N V  
Sbjct: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759

Query: 267 DDISHSQAVEVLKG 280
           ++ S  +AVE LKG
Sbjct: 760 ENSSLEEAVEALKG 773



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 16/60 (26%), Positives = 33/60 (55%), Gaps = 2/60 (3%)

Query: 222  LGFNIRGGKEFG-LGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
            LG ++ G K+   + +++  +D  G A ++G +++ D++L  NG      SH  A  ++K
Sbjct: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 30/248 (12%)

Query: 58   IRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVE 117
            +R +    R+++         +E+  I  V ++K     LG S+ G   +G G+F+S + 
Sbjct: 1505 LRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVG-KRNGSGVFISDIV 1563

Query: 118  EGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSK 176
            +G +A+  G L  GD+I  VNG  + + +  +   +L  +  L  +   +GR+    ++ 
Sbjct: 1564 KGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQL--EIGRLRAGSWTS 1621

Query: 177  EKTT------------------WVDVVN--RRLVVEKCGSTPSDTSS-EDGVRRIVHLYT 215
             +TT                  +  V+   + LV  K  S PS  +S  D   R V +  
Sbjct: 1622 ARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINR 1681

Query: 216  TSDDFCLGFNIRGGKEFGLG---IYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISH 271
               D  LG +I GG+   LG   ++++ +   G+A     +KVGD++++ NG   D +SH
Sbjct: 1682 ELSD-ALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSH 1740

Query: 272  SQAVEVLK 279
            +  V +LK
Sbjct: 1741 ADVVNLLK 1748



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 52/197 (26%), Positives = 87/197 (44%), Gaps = 37/197 (18%)

Query: 87   VRVEKSPAGRLGFSVRGGSEHGLGIFV--SKVEEGSSAERAGLCVGDKITEVNGLSLEST 144
            + + K  +G LG S+ GG +  L   V     EEG++A    L  GD+I EVNG+ L ++
Sbjct: 1438 IEISKGRSG-LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496

Query: 145  TMGSAVKVLTSS-SRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSS 203
            +   A+  L  +  ++ ++V R           ++  + D  N  +        P D   
Sbjct: 1497 SHEEAITALRQTPQKVRLVVYR-----------DEAHYRDEENLEIF-------PVDLQK 1538

Query: 204  EDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKV-GDQVLAAN 262
            + G               LG +I  GK  G G+++S +  GG A+ +G  + GDQ+L+ N
Sbjct: 1539 KAGRG-------------LGLSI-VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584

Query: 263  GVRFDDISHSQAVEVLK 279
            G    + S      +LK
Sbjct: 1585 GEDMRNASQETVATILK 1601



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 62/251 (24%), Positives = 102/251 (40%), Gaps = 35/251 (13%)

Query: 66  RVILINSPIEANSDESDIIHSVRVEKS-------------PAGRLGFSVRGGSEHGLGIF 112
           R+I+   P+   S  S  ++   + ++                 LGF + GG   G  + 
Sbjct: 214 RLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG--VV 271

Query: 113 VSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPG 171
           V  +  G  A+R G L  GD I ++ G +++  T     +VL +      M+        
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGD 331

Query: 172 IKFSKEKTTWVDVVNRRLVVEKCGSTPS--DTSSEDGVRRIVHLYTTSDDFCLGFNIRG- 228
           I  +      + V    +  +  GS  S  +T + + VR+        D   LG  I G 
Sbjct: 332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRK--------DGQSLGIRIVGY 383

Query: 229 -GKEF---GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK--GQ 281
            G        GIYV  +  G  A  NG I+V D+++A +GV     ++   VEVL+  GQ
Sbjct: 384 VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443

Query: 282 -THIMLTIKET 291
             H+ L  ++T
Sbjct: 444 VVHLTLVRRKT 454



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 58/242 (23%), Positives = 100/242 (41%), Gaps = 51/242 (21%)

Query: 87   VRVEKSPAGRLGFSVRGGS---------EHGLGIFVSKVEEGSSAERAG-LCVGDKITEV 136
            V + + P   LG S+ GG          E   GIF+ +V E S A +   L  GDKI EV
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128

Query: 137  NGLSLESTTMGSAVKVLTSSSR-LHMMVRRMGR----VPGIKFSKEKTTWVDVVNRRLVV 191
            +G+ L++ +   AV+ + ++   +  +V+ +      +P +     K T     + +   
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKK 1188

Query: 192  EK-CGSTP---------------SDTSSED----------------GVRRIVHLYTTSDD 219
            EK  G+ P               SD + E+                G   I+ L    D 
Sbjct: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL--EKDK 1246

Query: 220  FCLGFNIRGGKEFG-LGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEV 277
              LG ++ G K+   + I+V  ++  G A  +G +++GD++L  N       SH  A  +
Sbjct: 1247 NGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306

Query: 278  LK 279
            +K
Sbjct: 1307 IK 1308



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 11/84 (13%)

Query: 206  GVRRIVHLYTTSDDFCLGFNIRGGK---------EFGLGIYVSKV-DHGGLAEENGIKVG 255
            G  RIV ++    +  LG +I GG+         E   GI++ +V +     + N +K G
Sbjct: 1064 GPPRIVEIFR-EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122

Query: 256  DQVLAANGVRFDDISHSQAVEVLK 279
            D++L  +GV   + SHS+AVE +K
Sbjct: 1123 DKILEVSGVDLQNASHSEAVEAIK 1146



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 4/91 (4%)

Query: 70   INSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLG---IFVSKVE-EGSSAERA 125
            ++ P + NS       +V + +  +  LG S+ GG    LG   +F++ ++  G +A   
Sbjct: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719

Query: 126  GLCVGDKITEVNGLSLESTTMGSAVKVLTSS 156
             L VGD+I  +NG  L+  +    V +L ++
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 23/85 (27%), Positives = 45/85 (52%), Gaps = 4/85 (4%)

Query: 84   IHSVRVEKSPAGRLGFSVRGGSEHG-LGIFVSKVE-EGSSAERAGLCVGDKITEVNGLSL 141
            +H + +EK   G LG S+ G  +   + IFV  +  EG +A    + +GD++ E+N   L
Sbjct: 1237 LHIIELEKDKNG-LGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 142  ESTTMGSAVKVL-TSSSRLHMMVRR 165
               +  +A  ++ T+ S++ ++  R
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIR 1320


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 75/253 (29%), Positives = 122/253 (48%), Gaps = 58/253 (22%)

Query: 82  DIIHSVRVEKSPAGRLGFSVRGG--SEHGLG---IFVSKVEEGSSAERAG-LCVGDKITE 135
           + +  +++ K P G LGFS+ GG  ++H  G   I+V+K+ +G +A++ G L VGD++  
Sbjct: 138 ETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 196

Query: 136 VNGLSLESTTMGSAVKVL-TSSSRLHMMVRRMGRV--------PGIKFS----------- 175
           VN  SLE  T   AV +L  +S  +++ V +   +        P I  S           
Sbjct: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 256

Query: 176 ------KEKTTWVDV-------VNRRLVVEKCGSTPSDTS--------------SEDGVR 208
                 + KT+   +       + + ++V+   ++ S  S              S +G  
Sbjct: 257 GNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP 316

Query: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFD 267
           R V L+  S    LGFNI GG++ G GI+VS +  GG A+ +G ++ GDQ+L+ NG+   
Sbjct: 317 RKVVLHKGSTG--LGFNIVGGED-GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 373

Query: 268 DISHSQAVEVLKG 280
             SH QA   LKG
Sbjct: 374 GASHEQAAAALKG 386



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 56/212 (26%), Positives = 98/212 (46%), Gaps = 51/212 (24%)

Query: 87  VRVEKSPAGRLGFSVRGGSEH-----GLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLS 140
           + +E+  +G LGFS+ GG+++       GIF++K+  G +A   G L V D I  VN + 
Sbjct: 48  ITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106

Query: 141 LESTTMGSAVKVLTSS-SRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPS 199
           +   +   AV+ L  + S + + VRR                     RR ++E       
Sbjct: 107 VSEVSHSKAVEALKEAGSIVRLYVRR---------------------RRPILET------ 139

Query: 200 DTSSEDGVRRIVHLYTTSDDFCLGFNIRGGK-----EFGLGIYVSKVDHGGLAEENG-IK 253
                     +V +        LGF+I GG           IYV+K+  GG A+++G ++
Sbjct: 140 ----------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 189

Query: 254 VGDQVLAANGVRFDDISHSQAVEVLKGQTHIM 285
           VGD++L  N    ++++H +AV +LK  + ++
Sbjct: 190 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 221



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/63 (39%), Positives = 35/63 (55%), Gaps = 2/63 (3%)

Query: 97  LGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTS 155
           LGF++ GG E G GIFVS +  G  A+ +G L  GD+I  VNG+ L   +   A   L  
Sbjct: 328 LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386

Query: 156 SSR 158
           + +
Sbjct: 387 AGQ 389


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 84/335 (25%), Positives = 144/335 (42%), Gaps = 51/335 (15%)

Query: 56  RGIRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGG--SEHGLG--- 110
           R + A    G V+ +   +       + I  V + K P G LGFS+ GG  ++H  G   
Sbjct: 198 RAVEALKEAGPVVRL--VVRRRQPPPETIMEVNLLKGPKG-LGFSIAGGIGNQHIPGDNS 254

Query: 111 IFVSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRL-HMMVRRMGR 168
           I+++K+ EG +A++ G L +GD++  VN  +L+      AV  L ++S + ++ V + G 
Sbjct: 255 IYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGS 314

Query: 169 V-------PGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTS------------------- 202
           +       P    S       + ++    +   G+  S  S                   
Sbjct: 315 LHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHM 374

Query: 203 --SEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVL 259
              ED  R    +        LGFNI GG++ G GI+VS +  GG A+ +G ++ GD++L
Sbjct: 375 LAEEDFTREPRKIILHKGSTGLGFNIVGGED-GEGIFVSFILAGGPADLSGELRRGDRIL 433

Query: 260 AANGVRFDDISHSQAVEVLK--GQTHIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQ 317
           + NGV   + +H QA   LK  GQ+  ++       Y  ++  + +    +++ N     
Sbjct: 434 SVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDL--REQMMN----- 486

Query: 318 LSPASESSSSVSSCASSAPYSSGSLPSDR-MDICL 351
            S  S  S S+ +    + Y       DR  D CL
Sbjct: 487 -SSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCL 520



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 6/84 (7%)

Query: 202 SSEDGVRRIVHLYTTSDDFCLGFNIRGGKEF-----GLGIYVSKVDHGGLAEENG-IKVG 255
           +  DG+ +   +     +  LGF+I GG +        GI+++K+  GG A  +G + V 
Sbjct: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180

Query: 256 DQVLAANGVRFDDISHSQAVEVLK 279
           D VL  N V   ++ HS+AVE LK
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALK 204


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 39/87 (44%), Positives = 55/87 (63%), Gaps = 4/87 (4%)

Query: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEEN-GIKVGDQVLAANGVRFD 267
           R+V L  T +   LGFNI GGKE    IY+S+V  GG+A+ + G+K GDQ+L+ NGV  +
Sbjct: 92  RVVELPKTDEG--LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149

Query: 268 DISHSQAVEVLK-GQTHIMLTIKETGR 293
              H +AVE+LK  Q  + L ++ T R
Sbjct: 150 GEQHEKAVELLKAAQGSVKLVVRYTPR 176



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 31/85 (36%), Positives = 49/85 (57%), Gaps = 3/85 (3%)

Query: 87  VRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAER-AGLCVGDKITEVNGLSLESTT 145
           V + K+  G LGF++ GG E    I++S+V  G  A+R  GL  GD++  VNG+S+E   
Sbjct: 94  VELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQ 152

Query: 146 MGSAVKVL-TSSSRLHMMVRRMGRV 169
              AV++L  +   + ++VR   RV
Sbjct: 153 HEKAVELLKAAQGSVKLVVRYTPRV 177


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 40/98 (40%), Positives = 60/98 (61%), Gaps = 6/98 (6%)

Query: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEEN-GIKVGDQVLAANGVRFD 267
           R+V L  T +   LGFNI GGKE    IY+S++  GG+A+ + G+K GDQ+L+ NGV  +
Sbjct: 92  RVVELPKTEEG--LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149

Query: 268 DISHSQAVEVLK-GQTHIMLTIKETGRYPAYKEMVSEY 304
              H +AVE+LK  Q  + L ++ T +    +EM S +
Sbjct: 150 GEHHEKAVELLKAAQGKVKLVVRYTPK--VLEEMESRF 185



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 29/85 (34%), Positives = 50/85 (58%), Gaps = 3/85 (3%)

Query: 87  VRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAER-AGLCVGDKITEVNGLSLESTT 145
           V + K+  G LGF++ GG E    I++S++  G  A+R  GL  GD++  VNG+S+E   
Sbjct: 94  VELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEH 152

Query: 146 MGSAVKVL-TSSSRLHMMVRRMGRV 169
              AV++L  +  ++ ++VR   +V
Sbjct: 153 HEKAVELLKAAQGKVKLVVRYTPKV 177


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 62/239 (25%), Positives = 106/239 (44%), Gaps = 63/239 (26%)

Query: 72  SPIEANSDESDII------------HSVRVEKSPAGRLGFSVRGGSEH-----GLGIFVS 114
           +PI  N+D  D I              + +E+  +G LGFS+ GG+++       GIF++
Sbjct: 177 APIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFIT 235

Query: 115 KVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSS-SRLHMMVRRMGRVPGI 172
           K+  G +A   G L V D I  VN + +   +   AV+ L  + S + + VRR       
Sbjct: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 288

Query: 173 KFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGK-- 230
                         RR ++E                 +V +        LGF+I GG   
Sbjct: 289 --------------RRPILET----------------VVEIKLFKGPKGLGFSIAGGVGN 318

Query: 231 ---EFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIM 285
                   IYV+K+  GG A+++G ++VGD++L  N    ++++H +AV +LK  + ++
Sbjct: 319 QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 377



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 29/60 (48%), Positives = 40/60 (66%), Gaps = 2/60 (3%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
           LGFNI GG++ G GI+VS +  GG A+ +G ++ GDQ+L+ NG+     SH QA   LKG
Sbjct: 536 LGFNIVGGED-GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/63 (39%), Positives = 35/63 (55%), Gaps = 2/63 (3%)

Query: 97  LGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTS 155
           LGF++ GG E G GIFVS +  G  A+ +G L  GD+I  VNG+ L   +   A   L  
Sbjct: 536 LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594

Query: 156 SSR 158
           + +
Sbjct: 595 AGQ 597


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 62/239 (25%), Positives = 106/239 (44%), Gaps = 63/239 (26%)

Query: 72  SPIEANSDESDII------------HSVRVEKSPAGRLGFSVRGGSEH-----GLGIFVS 114
           +PI  N+D  D I              + +E+  +G LGFS+ GG+++       GIF++
Sbjct: 72  APIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFIT 130

Query: 115 KVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSS-SRLHMMVRRMGRVPGI 172
           K+  G +A   G L V D I  VN + +   +   AV+ L  + S + + VRR       
Sbjct: 131 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 183

Query: 173 KFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGK-- 230
                         RR ++E                 +V +        LGF+I GG   
Sbjct: 184 --------------RRPILET----------------VVEIKLFKGPKGLGFSIAGGVGN 213

Query: 231 ---EFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIM 285
                   IYV+K+  GG A+++G ++VGD++L  N    ++++H +AV +LK  + ++
Sbjct: 214 QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 272



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 29/60 (48%), Positives = 40/60 (66%), Gaps = 2/60 (3%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
           LGFNI GG++ G GI+VS +  GG A+ +G ++ GDQ+L+ NG+     SH QA   LKG
Sbjct: 431 LGFNIVGGED-GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/63 (39%), Positives = 35/63 (55%), Gaps = 2/63 (3%)

Query: 97  LGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTS 155
           LGF++ GG E G GIFVS +  G  A+ +G L  GD+I  VNG+ L   +   A   L  
Sbjct: 431 LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489

Query: 156 SSR 158
           + +
Sbjct: 490 AGQ 492


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 36/85 (42%), Positives = 54/85 (63%), Gaps = 4/85 (4%)

Query: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEEN-GIKVGDQVLAANGVRFD 267
           R+V L  T +   LGFN+ GGKE    IY+S++  GG+AE + G+K GDQ+L+ NGV  +
Sbjct: 107 RVVELPKTDEG--LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164

Query: 268 DISHSQAVEVLK-GQTHIMLTIKET 291
              H +AVE+LK  +  + L ++ T
Sbjct: 165 GEHHEKAVELLKAAKDSVKLVVRYT 189



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 28/71 (39%), Positives = 43/71 (60%), Gaps = 2/71 (2%)

Query: 87  VRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAER-AGLCVGDKITEVNGLSLESTT 145
           V + K+  G LGF+V GG E    I++S++  G  AER  GL  GD++  VNG+S+E   
Sbjct: 109 VELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167

Query: 146 MGSAVKVLTSS 156
              AV++L ++
Sbjct: 168 HEKAVELLKAA 178


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 69/241 (28%), Positives = 110/241 (45%), Gaps = 21/241 (8%)

Query: 75  EANSDESDIIHSVRVEKSPAGRLGFS-VRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDK 132
           +A     D  H +  + SP  +LG   VR   E G  +F+  V +G  A R G L   D+
Sbjct: 371 DAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDR 428

Query: 133 ITEVNGLSLESTTMGSAVKVLTSSSR-LHMMVRRMGRVPGIKFSKE-----KTTWVDVVN 186
           +  +NG  L   +  SA  ++ +S R +H++V R  R       +E       +W     
Sbjct: 429 VLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPG 488

Query: 187 RRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGG---KEFGLGIYVSKVDH 243
            R    K    P+ T  E    ++V++     +  LG  + GG   +E+ L IYV  V+ 
Sbjct: 489 ERSNTPK-PLHPTITCHE----KVVNIQKDPGE-SLGMTVAGGASHREWDLPIYVISVEP 542

Query: 244 GGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-GQTHIMLTIKETGRYPAYKEMV 301
           GG+   +G IK GD +L  +GV   ++S S+AV +LK   + I+L   E   Y   ++  
Sbjct: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 602

Query: 302 S 302
           S
Sbjct: 603 S 603


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 69/241 (28%), Positives = 110/241 (45%), Gaps = 21/241 (8%)

Query: 75  EANSDESDIIHSVRVEKSPAGRLGFS-VRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDK 132
           +A     D  H +  + SP  +LG   VR   E G  +F+  V +G  A R G L   D+
Sbjct: 275 DAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDR 332

Query: 133 ITEVNGLSLESTTMGSAVKVLTSSSR-LHMMVRRMGRVPGIKFSKE-----KTTWVDVVN 186
           +  +NG  L   +  SA  ++ +S R +H++V R  R       +E       +W     
Sbjct: 333 VLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPG 392

Query: 187 RRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGG---KEFGLGIYVSKVDH 243
            R    K    P+ T  E    ++V++     +  LG  + GG   +E+ L IYV  V+ 
Sbjct: 393 ERSNTPK-PLHPTITCHE----KVVNIQKDPGE-SLGMTVAGGASHREWDLPIYVISVEP 446

Query: 244 GGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-GQTHIMLTIKETGRYPAYKEMV 301
           GG+   +G IK GD +L  +GV   ++S S+AV +LK   + I+L   E   Y   ++  
Sbjct: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 506

Query: 302 S 302
           S
Sbjct: 507 S 507


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 59/211 (27%), Positives = 100/211 (47%), Gaps = 34/211 (16%)

Query: 113  VSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPG 171
            + ++ EGS A+R G L VGD+I  VNG S+ + +    V ++  +   + +  R+  +PG
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG--NTVTLRI--IPG 1093

Query: 172  IKFSK-------EKTTWVDVVN----------RRLVVEKCGS-----TPSDTSSEDGVRR 209
             + S        EK   +   +          R     K  S      P  T  +D    
Sbjct: 1094 DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT- 1152

Query: 210  IVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDD 268
             V L   +  F  GF++RGG+E+ + +YV ++   G AE  G +++GD++L  NG    +
Sbjct: 1153 -VELERGAKGF--GFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1209

Query: 269  ISHSQAVEVLK-GQTHIMLTIKE-TGRYPAY 297
            + HS+A+E++K G   + L +K   G  P Y
Sbjct: 1210 MKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1240



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 24/75 (32%), Positives = 47/75 (62%), Gaps = 2/75 (2%)

Query: 85   HSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLES 143
            ++V +E+   G  GFS+RGG E+ + ++V ++ E   AER G + +GD+I E+NG + ++
Sbjct: 1151 YTVELERGAKG-FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1209

Query: 144  TTMGSAVKVLTSSSR 158
                 A++++ +  R
Sbjct: 1210 MKHSRAIELIKNGGR 1224



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 4/71 (5%)

Query: 223 GFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-- 279
           GF I GG E G  IY+  +   G A+ +G ++ GD+++  +G      SH   V++++  
Sbjct: 852 GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911

Query: 280 -GQTHIMLTIK 289
             Q H+ LT++
Sbjct: 912 AKQGHVNLTVR 922



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 8/94 (8%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG------LCVGDKITEVN 137
           +H   V++ P G LG +V GG+EHG   +V  V    +A   G      L  G+ + EV 
Sbjct: 15  VHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQ 74

Query: 138 GLSLESTTMGSAVKVLTSSSR--LHMMVRRMGRV 169
           G+ +        + V+ S         VR+ GR+
Sbjct: 75  GVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRL 108


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 59/211 (27%), Positives = 100/211 (47%), Gaps = 34/211 (16%)

Query: 113  VSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPG 171
            + ++ EGS A+R G L VGD+I  VNG S+ + +    V ++  +   + +  R+  +PG
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG--NTVTLRI--IPG 1064

Query: 172  IKFSK-------EKTTWVDVVN----------RRLVVEKCGS-----TPSDTSSEDGVRR 209
             + S        EK   +   +          R     K  S      P  T  +D    
Sbjct: 1065 DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT- 1123

Query: 210  IVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDD 268
             V L   +  F  GF++RGG+E+ + +YV ++   G AE  G +++GD++L  NG    +
Sbjct: 1124 -VELERGAKGF--GFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1180

Query: 269  ISHSQAVEVLK-GQTHIMLTIKE-TGRYPAY 297
            + HS+A+E++K G   + L +K   G  P Y
Sbjct: 1181 MKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 24/75 (32%), Positives = 47/75 (62%), Gaps = 2/75 (2%)

Query: 85   HSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLES 143
            ++V +E+   G  GFS+RGG E+ + ++V ++ E   AER G + +GD+I E+NG + ++
Sbjct: 1122 YTVELERGAKG-FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1180

Query: 144  TTMGSAVKVLTSSSR 158
                 A++++ +  R
Sbjct: 1181 MKHSRAIELIKNGGR 1195



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 47/195 (24%), Positives = 75/195 (38%), Gaps = 31/195 (15%)

Query: 223  GFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-- 279
            GF I GG E G  IY+  +   G A+ +G ++ GD+++  +G      SH   V++++  
Sbjct: 824  GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 883

Query: 280  -GQTHIMLTIKETGRYPAYK---------------EMVSEYCWLDRLSNGVLQQLSPASE 323
              Q H+ LT++    +   K                  +      R   G    L+  S 
Sbjct: 884  AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSS 943

Query: 324  SSSSVSSCASSAPYSSGSL-----PSDRMDICLGQEEPGSRGPGWGRADTAMQTEPDAGG 378
             S S S   S     SG +     P D ++I  G+ E      G+G    +  + P+AG 
Sbjct: 944  GSGSTSGIGSGGGGGSGVVSTVVQPYD-VEIRRGENE------GFGFVIVSSVSRPEAGT 996

Query: 379  RVETWCSVRPTVILR 393
                 C   P  I R
Sbjct: 997  TFGNACVAMPHKIGR 1011



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 8/94 (8%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG------LCVGDKITEVN 137
           +H   V++ P G LG +V GG+EHG   +V  V    +A   G      L  G+ + EV 
Sbjct: 15  VHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQ 74

Query: 138 GLSLESTTMGSAVKVLTSSSR--LHMMVRRMGRV 169
           G+ +        + V+ S         VR+ GR+
Sbjct: 75  GVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRL 108


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 59/211 (27%), Positives = 100/211 (47%), Gaps = 34/211 (16%)

Query: 113  VSKVEEGSSAERAG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPG 171
            + ++ EGS A+R G L VGD+I  VNG S+ + +    V ++  +   + +  R+  +PG
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG--NTVTLRI--IPG 1092

Query: 172  IKFSK-------EKTTWVDVVN----------RRLVVEKCGS-----TPSDTSSEDGVRR 209
             + S        EK   +   +          R     K  S      P  T  +D    
Sbjct: 1093 DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT- 1151

Query: 210  IVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDD 268
             V L   +  F  GF++RGG+E+ + +YV ++   G AE  G +++GD++L  NG    +
Sbjct: 1152 -VELERGAKGF--GFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1208

Query: 269  ISHSQAVEVLK-GQTHIMLTIKE-TGRYPAY 297
            + HS+A+E++K G   + L +K   G  P Y
Sbjct: 1209 MKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1239



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 24/75 (32%), Positives = 47/75 (62%), Gaps = 2/75 (2%)

Query: 85   HSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLES 143
            ++V +E+   G  GFS+RGG E+ + ++V ++ E   AER G + +GD+I E+NG + ++
Sbjct: 1150 YTVELERGAKG-FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1208

Query: 144  TTMGSAVKVLTSSSR 158
                 A++++ +  R
Sbjct: 1209 MKHSRAIELIKNGGR 1223



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 47/195 (24%), Positives = 75/195 (38%), Gaps = 31/195 (15%)

Query: 223  GFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-- 279
            GF I GG E G  IY+  +   G A+ +G ++ GD+++  +G      SH   V++++  
Sbjct: 852  GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911

Query: 280  -GQTHIMLTIKETGRYPAYK---------------EMVSEYCWLDRLSNGVLQQLSPASE 323
              Q H+ LT++    +   K                  +      R   G    L+  S 
Sbjct: 912  AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSS 971

Query: 324  SSSSVSSCASSAPYSSGSL-----PSDRMDICLGQEEPGSRGPGWGRADTAMQTEPDAGG 378
             S S S   S     SG +     P D ++I  G+ E      G+G    +  + P+AG 
Sbjct: 972  GSGSTSGIGSGGGGGSGVVSTVVQPYD-VEIRRGENE------GFGFVIVSSVSRPEAGT 1024

Query: 379  RVETWCSVRPTVILR 393
                 C   P  I R
Sbjct: 1025 TFGNACVAMPHKIGR 1039



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 8/94 (8%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG------LCVGDKITEVN 137
           +H   V++ P G LG +V GG+EHG   +V  V    +A   G      L  G+ + EV 
Sbjct: 15  VHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQ 74

Query: 138 GLSLESTTMGSAVKVLTSSSR--LHMMVRRMGRV 169
           G+ +        + V+ S         VR+ GR+
Sbjct: 75  GVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRL 108


>gi|21361142 PDZ domain containing 1 [Homo sapiens]
          Length = 519

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 67/252 (26%), Positives = 109/252 (43%), Gaps = 38/252 (15%)

Query: 96  RLGFSVRGGSEHGL---------GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTM 146
           RL + V+ G  +G          G++++ +     A RAG+   D + EVNG ++E  + 
Sbjct: 134 RLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASH 193

Query: 147 GSAV-KVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSED 205
              V KV  S SR+  ++                  VD    +  VE+      +T+S  
Sbjct: 194 EEVVEKVKKSGSRVMFLL------------------VDKETDKRHVEQKIQFKRETASLK 235

Query: 206 GVR---RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAAN 262
            +    RIV +   S+ +  GF +R G E   G  +  +D G  AEE G+K  D V+A N
Sbjct: 236 LLPHQPRIVEMKKGSNGY--GFYLRAGSE-QKGQIIKDIDSGSPAEEAGLKNNDLVVAVN 292

Query: 263 GVRFDDISHSQAVEVLK---GQTHIMLTIKET-GRYPAYKEMVSEYCWLDRLSNGVLQQL 318
           G   + + H   VE+++    QT +++  KET   Y         Y     L NG +++ 
Sbjct: 293 GESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEA 352

Query: 319 SPASESSSSVSS 330
              + +S  VSS
Sbjct: 353 PAPTPTSLEVSS 364



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 47/194 (24%), Positives = 85/194 (43%), Gaps = 17/194 (8%)

Query: 110 GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRV 169
           G  V  VE+ S AE+AGL  GD++  +NG+ ++       V ++  S     ++     +
Sbjct: 32  GHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL----VL 87

Query: 170 PGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTS--SEDGVR-----RIVHLYTTSDDFCL 222
            G  + K   T VD+       ++ G + +  S     GV+     R+ +L      +  
Sbjct: 88  DGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGF 147

Query: 223 GFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLK--- 279
                 GK+   G+Y++ +   G+A   G+   D ++  NG   +D SH + VE +K   
Sbjct: 148 SLKTVQGKK---GVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSG 204

Query: 280 GQTHIMLTIKETGR 293
            +   +L  KET +
Sbjct: 205 SRVMFLLVDKETDK 218



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 19/200 (9%)

Query: 91  KSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAV 150
           K  +   GF +R GSE   G  +  ++ GS AE AGL   D +  VNG S+E+    S V
Sbjct: 247 KKGSNGYGFYLRAGSEQK-GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVV 305

Query: 151 KV----------LTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKC--GSTP 198
           ++          L        M R     P + +  ++     V             S+P
Sbjct: 306 EMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSP 365

Query: 199 SDTSSE-DGVRRIVHLYTTSDDFCLGFNIRGGKEFGL-GIYVSKVDHGGLAEENGIKVGD 256
            DT+ E D   ++  L    + +  GF++   +  GL G ++ +V  GG A+  G++  D
Sbjct: 366 PDTTEEVDHKPKLCRLAKGENGY--GFHLNAIR--GLPGSFIKEVQKGGPADLAGLEDED 421

Query: 257 QVLAANGVRFDDISHSQAVE 276
            ++  NGV   D  + + V+
Sbjct: 422 VIIEVNGVNVLDEPYEKVVD 441



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 31/118 (26%), Positives = 56/118 (47%), Gaps = 6/118 (5%)

Query: 42  YLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSV 101
           +L  + Q L NG  +   A +P    + ++SP +   +   + H  ++ +   G  G+  
Sbjct: 336 FLYYQSQELPNGSVKEAPAPTPTS--LEVSSPPDTTEE---VDHKPKLCRLAKGENGYGF 390

Query: 102 RGGSEHGL-GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSR 158
              +  GL G F+ +V++G  A+ AGL   D I EVNG+++        V  + SS +
Sbjct: 391 HLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGK 448



 Score = 33.1 bits (74), Expect = 0.63
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 9/60 (15%)

Query: 229 GKEFGLGIYVSKVDHGGL---------AEENGIKVGDQVLAANGVRFDDISHSQAVEVLK 279
           G+ +G  + + K   G L         AE+ G++ GD+VL  NGV  D   H Q V++++
Sbjct: 17  GQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVR 76


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 32/80 (40%), Positives = 53/80 (66%), Gaps = 3/80 (3%)

Query: 223  GFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK-G 280
            GF+IRGG+E+ + +YV ++   G A  NG ++VGDQ++  NG    D++H++A+E++K G
Sbjct: 1158 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG 1217

Query: 281  QTHIMLTIKE-TGRYPAYKE 299
               + L +K  TG+ P Y E
Sbjct: 1218 GRRVRLLLKRGTGQVPEYDE 1237



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/88 (36%), Positives = 54/88 (61%), Gaps = 4/88 (4%)

Query: 86   SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLEST 144
            +V +EK   G  GFS+RGG E+ + ++V ++ E   A R G + VGD+I E+NG S    
Sbjct: 1147 TVDMEKGAKG-FGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDM 1205

Query: 145  TMGSAVKVLTSSS-RLHMMVRR-MGRVP 170
            T   A++++ S   R+ ++++R  G+VP
Sbjct: 1206 THARAIELIKSGGRRVRLLLKRGTGQVP 1233



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 30/222 (13%)

Query: 84  IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLE 142
           +H  R+E       GF + GG E G  I +  V    SA+R G L  GD++  V+G+ + 
Sbjct: 779 VHLRRMESG----FGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834

Query: 143 STTMGSAVKVLTSSSR---LHMMVRRM-----------GRVPG---IKFSKEKTTWVDVV 185
             T    + ++  ++R   +++ VRR            GR PG      S  ++ +    
Sbjct: 835 GKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYT 894

Query: 186 NRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNI-------RGGKEFGLGIYV 238
           N         ++P +  +   ++    +    ++   GF I         G    +   +
Sbjct: 895 NSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKI 954

Query: 239 SKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLK 279
            ++  G  A+    +KVGD++LA NG    ++ H+  V+++K
Sbjct: 955 GRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 21/86 (24%), Positives = 46/86 (53%), Gaps = 2/86 (2%)

Query: 70  INSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG--L 127
           ++  ++  S  +  +H   + ++P G+LGF ++GG+E+G   ++ +V+ G  A  +G  L
Sbjct: 1   MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 60

Query: 128 CVGDKITEVNGLSLESTTMGSAVKVL 153
              + + EVN   +   T+   + V+
Sbjct: 61  VSEELLLEVNETPVAGLTIRDVLAVI 86



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 15/38 (39%), Positives = 23/38 (60%)

Query: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVL 259
           LGF ++GG E G   Y+ +V  G +A E+G K+  + L
Sbjct: 28  LGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEEL 65


>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
           [Homo sapiens]
          Length = 1104

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 75/266 (28%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 23  SSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESD 82
           S L +    G+DS  T     L+ Q +    P  G + SSP    ++      +N +   
Sbjct: 326 SGLKTANLTGTDSPETDASASLQ-QNKSPRVPRLGGKPSSPSLSPLM---GFGSNKNAKK 381

Query: 83  IIHSVRVEKSPAGRLGFSV--RGGSEHGLG-IFVSKV-EEGSSAERAGLCVGDKITEVNG 138
           I   + ++K P G LGF+V  R  S HG G IFV  +  +G++ +   L  GD+I EVNG
Sbjct: 382 I--KIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNG 438

Query: 139 LSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTP 198
             +   T    V +L S+        + G    +  ++++  ++    R L  E      
Sbjct: 439 RDVTGRTQEELVAMLRST--------KQGETASLVIARQEGHFLP---RELKGEPDCCAL 487

Query: 199 SDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGK--EFG--LGIYVSKVDHGGLAEENG-IK 253
           S  +SE     I      S    LG +++G K  E G  LGI++  + HGG A ++G ++
Sbjct: 488 SLETSEQLTFEIP--LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLR 545

Query: 254 VGDQVLAANGVRFDDISHSQAVEVLK 279
           + DQ++A NG      S+ +A+E L+
Sbjct: 546 MNDQLIAVNGESLLGKSNHEAMETLR 571


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
           [Homo sapiens]
          Length = 1136

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 75/266 (28%), Positives = 123/266 (46%), Gaps = 29/266 (10%)

Query: 23  SSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESD 82
           S L +    G+DS  T     L+ Q +    P  G + SSP    ++      +N +   
Sbjct: 326 SGLKTANLTGTDSPETDASASLQ-QNKSPRVPRLGGKPSSPSLSPLM---GFGSNKNAKK 381

Query: 83  IIHSVRVEKSPAGRLGFSV--RGGSEHGLG-IFVSKV-EEGSSAERAGLCVGDKITEVNG 138
           I   + ++K P G LGF+V  R  S HG G IFV  +  +G++ +   L  GD+I EVNG
Sbjct: 382 I--KIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNG 438

Query: 139 LSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTP 198
             +   T    V +L S+        + G    +  ++++  ++    R L  E      
Sbjct: 439 RDVTGRTQEELVAMLRST--------KQGETASLVIARQEGHFLP---RELKGEPDCCAL 487

Query: 199 SDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGK--EFG--LGIYVSKVDHGGLAEENG-IK 253
           S  +SE     I      S    LG +++G K  E G  LGI++  + HGG A ++G ++
Sbjct: 488 SLETSEQLTFEIP--LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLR 545

Query: 254 VGDQVLAANGVRFDDISHSQAVEVLK 279
           + DQ++A NG      S+ +A+E L+
Sbjct: 546 MNDQLIAVNGESLLGKSNHEAMETLR 571


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,755,722
Number of Sequences: 37866
Number of extensions: 1000726
Number of successful extensions: 3560
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 2902
Number of HSP's gapped (non-prelim): 614
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.