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Search of human proteins with 4759140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
(358 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 712 0.0
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 327 1e-89
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 321 6e-88
gi|21361142 PDZ domain containing 1 [Homo sapiens] 162 4e-40
gi|21630285 PDZ domain containing 3 [Homo sapiens] 120 1e-27
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo... 82 6e-16
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 75 1e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 75 1e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 75 1e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 75 1e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 74 2e-13
gi|112382257 InaD-like [Homo sapiens] 72 6e-13
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 72 8e-13
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 71 1e-12
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 71 2e-12
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 71 2e-12
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 69 5e-12
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 69 5e-12
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 69 5e-12
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 69 6e-12
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 69 6e-12
gi|45827729 scribble isoform b [Homo sapiens] 67 3e-11
gi|45827731 scribble isoform a [Homo sapiens] 67 3e-11
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 66 4e-11
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 66 4e-11
gi|41281808 harmonin isoform b3 [Homo sapiens] 64 3e-10
gi|71480164 harmonin isoform a [Homo sapiens] 64 3e-10
gi|148746189 multiple PDZ domain protein [Homo sapiens] 62 1e-09
gi|31742501 sorting nexin family member 27 [Homo sapiens] 62 1e-09
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 60 4e-09
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 712 bits (1839), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV 60
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV
Sbjct: 1 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV 60
Query: 61 EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA 120
EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA
Sbjct: 61 EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA 120
Query: 121 EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR 180
EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR
Sbjct: 121 EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR 180
Query: 181 SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK 240
SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK
Sbjct: 181 SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK 240
Query: 241 KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ 300
KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ
Sbjct: 241 KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ 300
Query: 301 DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL 358
DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
Sbjct: 301 DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL 358
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 327 bits (838), Expect = 1e-89
Identities = 187/359 (52%), Positives = 225/359 (62%), Gaps = 31/359 (8%)
Query: 6 AAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNG 64
AA PL PRLC L +G GYGFHLHGEKG+ GQ+IR VEPGSPAE A L AGDRLVEVNG
Sbjct: 2 AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNG 61
Query: 65 ENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPA 124
NVE ETH QVV RI+A RLLVVD ETDE+L++ + EE+ AQ A P
Sbjct: 62 VNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPPAHDPW 119
Query: 125 AAEVQGAGNENEPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSV 182
+ A + EA K RELRPRLC ++KGP GYGFNLHSDKS+PGQ+IRSV
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSV 179
Query: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242
DP SPA SGLRAQDR++EVNG +EG +H +VV++I+A DE +LLVVD ETDE FK+
Sbjct: 180 DPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
Query: 243 RVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302
RV P++EH+ GPLP P TNG PA + S+ +S D
Sbjct: 240 RVTPTEEHVEGPLPSPVTNG------------------TSPAQLNGGSACSSR----SDL 277
Query: 303 PPKQDSTAPSSTSSSDPILDFNISL----AMAKERAHQKRSSKRAPQMDWSKKNELFSN 357
P T S DP + + L A AKE+A R +KRAPQMDW++K E+FSN
Sbjct: 278 PGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSN 336
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 321 bits (823), Expect = 6e-88
Identities = 185/355 (52%), Positives = 223/355 (62%), Gaps = 34/355 (9%)
Query: 6 AAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNG 64
AA PL PRLC L +G GYGFHLHGEKG+ GQ+IR VEPGSPAE A L AGDRLVEVNG
Sbjct: 2 AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNG 61
Query: 65 ENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPA 124
NVE ETH QVV RI+A RLLVVD ETDE+L++ + EE+ AQ A P
Sbjct: 62 VNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPPAHDPW 119
Query: 125 AAEVQGAGNENEPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSV 182
+ A + EA K RELRPRLC ++KGP GYGFNLHSDKS+PGQ+IRSV
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSV 179
Query: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242
DP SPA SGLRAQDR++EVNG +EG +H +VV++I+A DE +LLVVD ETDE FK+
Sbjct: 180 DPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
Query: 243 RVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302
RV P++EH+ GPLP P TNG PA + S+ +S D
Sbjct: 240 RVTPTEEHVEGPLPSPVTNG------------------TSPAQLNGGSACSSR----SDL 277
Query: 303 PPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSN 357
P T S L + + A AKE+A R +KRAPQMDW++K E+FSN
Sbjct: 278 PGSDKDTEESG-------LHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSN 325
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 162 bits (410), Expect = 4e-40
Identities = 105/294 (35%), Positives = 149/294 (50%), Gaps = 49/294 (16%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET 71
PRLC L K YGF L +GK G Y+ + P A +AG+LA D L+EVNGENVE +
Sbjct: 133 PRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDAS 192
Query: 72 HQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA 131
H++VV +++ + + V L+VD ETD++ + +Q + E + P Q
Sbjct: 193 HEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ------------ 240
Query: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEAS 191
PR+ MKKG +GYGF L + + GQ I+ +D SPAE +
Sbjct: 241 --------------------PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEA 280
Query: 192 GLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHL 251
GL+ D +V VNG +E H VV IR GGD+T LLVVD+ETD ++ P +
Sbjct: 281 GLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQ 340
Query: 252 NGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPK 305
+ LP NG ++ EA +P +L S+ DT+EE+ D PK
Sbjct: 341 SQELP----NGSVK---------EAPAPTP-TSLEVSSPPDTTEEV---DHKPK 377
Score = 151 bits (382), Expect = 8e-37
Identities = 98/291 (33%), Positives = 153/291 (52%), Gaps = 14/291 (4%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET 71
PR+ ++KG NGYGF+L + GQ I+ ++ GSPAE+AGL D +V VNGE+VE
Sbjct: 241 PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD 300
Query: 72 HQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA 131
H VV IR + LLVVD ETD + +L ++QE P + A A +
Sbjct: 301 HDSVVEMIRKGGDQTSLLVVDKETD-NMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTS 359
Query: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEAS 191
+ P + E+ + +P+LC + KG +GYGF+L++ + PG FI+ V PA+ +
Sbjct: 360 LEVSSPPDT----TEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLA 415
Query: 192 GLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHL 251
GL +D I+EVNGV + + + VV I++ G LLV ++ ++F + + IP L
Sbjct: 416 GLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYF-QAKKIPIVSSL 474
Query: 252 NGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302
PL P +S+E + + A R+ S+ + NS+D+
Sbjct: 475 ADPLDTP--------PDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDT 517
Score = 134 bits (336), Expect = 2e-31
Identities = 84/228 (36%), Positives = 125/228 (54%), Gaps = 18/228 (7%)
Query: 12 PRLCCLEK--GPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEK 69
PR C L K G N YGF L EK G +R+VE SPAEKAGL GDR++ +NG V+K
Sbjct: 7 PRECKLSKQEGQN-YGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDK 65
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
E H QVV +R + N+V LLV+D ++ E+ K V ++ EL ++Q+ G ++ + +
Sbjct: 66 EEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLK-ELGQSQKEQGLSDNILSPVMN 124
Query: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAE 189
G Q +PRLC + K YGF+L + + K G ++ + P A
Sbjct: 125 GG--------------VQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAM 170
Query: 190 ASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDE 237
+G+ A D ++EVNG +E H +VV ++ G L+VD+ETD+
Sbjct: 171 RAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218
Score = 68.2 bits (165), Expect = 1e-11
Identities = 41/122 (33%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 152 PRLCTMKKGPS-GYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGK 210
PR C + K YGF L +K G +R V+ SPAE +GL+ DR++ +NGV ++ +
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
Query: 211 QHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRV-------IPSQEHLNGPLPVPFTNGE 263
+H VV +R G+ LLV+D ++ E K RV ++ L+ + P NG
Sbjct: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGG 126
Query: 264 IQ 265
+Q
Sbjct: 127 VQ 128
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 120 bits (302), Expect = 1e-27
Identities = 83/203 (40%), Positives = 107/203 (52%), Gaps = 9/203 (4%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKG---KLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVE 68
PR LEKGP G+GF L EKG + GQ++ V+PG PA+KAG+ AGDRLV V GE+VE
Sbjct: 247 PRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVE 306
Query: 69 KETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEV 128
H++ VSRI+ + V L VVDPE D + + LL + A P ++
Sbjct: 307 GLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRL---SPLLFLENTEAPASPQGSSSA 363
Query: 129 QGAGNENEPREADKSHPEQRELRPRLCTMKKGPSG-YGFNLHSDKSKPGQFIRSVDPDSP 187
E +P D S P L R C + GP G YGF L S P FI V P
Sbjct: 364 SLVETE-DPSLEDTSVPSV-PLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGS 421
Query: 188 AEASGLRAQDRIVEVNGVCMEGK 210
A +GL+ D I+EVNG + G+
Sbjct: 422 AARAGLQVGDVILEVNGYPVGGQ 444
Score = 120 bits (300), Expect = 2e-27
Identities = 99/298 (33%), Positives = 132/298 (44%), Gaps = 63/298 (21%)
Query: 12 PRLCCLEKGPN-GYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKE 70
PR C L K +GFHL E G+ G + V+PG+ A++ GL GDR++ VN + VE E
Sbjct: 47 PRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHE 106
Query: 71 THQQVVSRIRAALNAVRLLVVDPETDEQLQ-----------KLGVQVREEL--------- 110
+ VV RIRA+ V L V+ + + LG VR L
Sbjct: 107 DYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGG 166
Query: 111 -----LRAQEAP--------GQAE----PPAA--AEVQG------------AGNENE--- 136
+ P G AE PP A EV G AG E E
Sbjct: 167 FGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQC 226
Query: 137 -----PREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDK---SKPGQFIRSVDPDSPA 188
P A + +PR ++KGP G+GF L +K +PGQF+ VDP PA
Sbjct: 227 RQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPA 286
Query: 189 EASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIP 246
+ +G++A DR+V V G +EG H + VS I+ G L VVD E D FF R+ P
Sbjct: 287 KKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344
Score = 52.4 bits (124), Expect = 6e-07
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 151 RPRLCTMKKGPS-GYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEG 209
RPR C + K +GF+L + + G + VDP + A+ GL+ DRI+ VN +E
Sbjct: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
Query: 210 KQHGDVVSAIRAGGDETKLLVVDRETDE 237
+ + VV IRA L V+ R +
Sbjct: 106 EDYAVVVRRIRASSPRVLLTVLARHAHD 133
>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
sapiens]
Length = 227
Score = 82.4 bits (202), Expect = 6e-16
Identities = 47/147 (31%), Positives = 79/147 (53%), Gaps = 5/147 (3%)
Query: 112 RAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSD 171
++QE P + A A + + P + E+ + +P+LC + KG +GYGF+L++
Sbjct: 19 QSQELPNGSVKEAPAPTPTSLEVSSPPDTT----EEEDHKPKLCRLAKGENGYGFHLNAI 74
Query: 172 KSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVV 231
+ PG FI+ V PA+ +GL +D I+EVNGV + + + VV I++ G LLV
Sbjct: 75 RGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVC 134
Query: 232 DRETDEFFKKCRVIPSQEHLNGPLPVP 258
++ ++F + + IP L PL P
Sbjct: 135 GKKAYDYF-QAKKIPIVSSLADPLDTP 160
Score = 79.3 bits (194), Expect = 5e-15
Identities = 43/116 (37%), Positives = 65/116 (56%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET 71
P+LC L KG NGYGFHL+ +G G +I+ V+ G PA+ AGL D ++EVNG NV E
Sbjct: 55 PKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEP 114
Query: 72 HQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAE 127
+++VV RI+++ V LLV + + Q + + L + P ++ E
Sbjct: 115 YEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVE 170
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 74.7 bits (182), Expect = 1e-13
Identities = 84/321 (26%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPE 94
G Y++ V P AE G + GDR++ VNG ++E TH+Q V +R V LL+ +
Sbjct: 1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ 1458
Query: 95 TDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRL 154
+ + + V + L Q A GQ Q K + E
Sbjct: 1459 SPTSKEHVPV-TPQCTLSDQNAQGQGPEKVKKTTQ-----------VKDYSFVTEENTFE 1506
Query: 155 CTMKKGPSGYGFNL-HSDKSKPGQF------IRSVDPDSPAEASG-LRAQDRIVEVNGVC 206
+ K SG GF+ D P Q ++ + P PA SG + D I++VNG
Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566
Query: 207 MEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQK 266
++G +V+SA+R E LL+ CR P G LP T
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLL-----------CRPPP------GVLPEIDTALLTPL 1609
Query: 267 ENSREALAEAALESPRPALVRSASSDTSEELNSQD-----SPPKQDSTAPSSTSSSDPIL 321
++ + L ++ +S +P+ V ++S E++ + SP ++DS + SS S D ++
Sbjct: 1610 QSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLV 1669
Query: 322 --DFNISLAMAKERAHQKRSS 340
NIS + HQ S+
Sbjct: 1670 TAPANISNSTWSSALHQTLSN 1690
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 7/85 (8%)
Query: 23 GYGFHLHG--EKGKL--GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQQVVS 77
G GF + G + G+L G +I V PG PA+ G L GDRL+ VN ++E +H +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 78 RIRAALNAVRLLVVDPETDEQLQKL 102
++ A V L++ P+ E++ K+
Sbjct: 1163 ILQNAPEDVTLVISQPK--EKISKV 1185
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 18 EKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77
EKG GF + ++G Y+ V L GDRL++VN +V TH V+
Sbjct: 1800 EKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1857
Query: 78 RIRAALNAVRLLV 90
+RAA VRL++
Sbjct: 1858 LLRAASKTVRLVI 1870
Score = 39.3 bits (90), Expect = 0.005
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 19/132 (14%)
Query: 115 EAPGQAEPPAAAEVQGAGNENEP---READKSHPE-------QRELRPRLCTMKKGPS-G 163
E PGQA + +GN + +E D H +RE+ L +KK G
Sbjct: 1047 EDPGQAYV-LGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREIT--LVNLKKDAKYG 1103
Query: 164 YGFNLHSDKSKP----GQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA 218
GF + + G FI SV P PA+ G L+ DR++ VN V +EG H +
Sbjct: 1104 LGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 1163
Query: 219 IRAGGDETKLLV 230
++ ++ L++
Sbjct: 1164 LQNAPEDVTLVI 1175
Score = 38.5 bits (88), Expect = 0.009
Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 116 APGQAEPPAAAEVQGAGNE-------NEPREAD---------KSHPEQRELRPRLC-TMK 158
APGQ+ P + + + +EP + ++H E EL L T+
Sbjct: 1738 APGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLI 1797
Query: 159 KGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVV 216
K G GF + + G ++ V D PA++ G L+ DR+++VN + H D V
Sbjct: 1798 KSEKGSLGFTVTKGNQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAV 1856
Query: 217 SAIRAGGDETKLLV 230
+ +RA +L++
Sbjct: 1857 NLLRAASKTVRLVI 1870
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 74.7 bits (182), Expect = 1e-13
Identities = 84/321 (26%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPE 94
G Y++ V P AE G + GDR++ VNG ++E TH+Q V +R V LL+ +
Sbjct: 1203 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ 1262
Query: 95 TDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRL 154
+ + + V + L Q A GQ Q K + E
Sbjct: 1263 SPTSKEHVPV-TPQCTLSDQNAQGQGPEKVKKTTQ-----------VKDYSFVTEENTFE 1310
Query: 155 CTMKKGPSGYGFNL-HSDKSKPGQF------IRSVDPDSPAEASG-LRAQDRIVEVNGVC 206
+ K SG GF+ D P Q ++ + P PA SG + D I++VNG
Sbjct: 1311 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 207 MEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQK 266
++G +V+SA+R E LL+ CR P G LP T
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLL-----------CRPPP------GVLPEIDTALLTPL 1413
Query: 267 ENSREALAEAALESPRPALVRSASSDTSEELNSQD-----SPPKQDSTAPSSTSSSDPIL 321
++ + L ++ +S +P+ V ++S E++ + SP ++DS + SS S D ++
Sbjct: 1414 QSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLV 1473
Query: 322 --DFNISLAMAKERAHQKRSS 340
NIS + HQ S+
Sbjct: 1474 TAPANISNSTWSSALHQTLSN 1494
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 7/85 (8%)
Query: 23 GYGFHLHG--EKGKL--GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQQVVS 77
G GF + G + G+L G +I V PG PA+ G L GDRL+ VN ++E +H +
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 78 RIRAALNAVRLLVVDPETDEQLQKL 102
++ A V L++ P+ E++ K+
Sbjct: 972 ILQNAPEDVTLVISQPK--EKISKV 994
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 18 EKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77
EKG GF + ++G Y+ V L GDRL++VN +V TH V+
Sbjct: 1604 EKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1661
Query: 78 RIRAALNAVRLLV 90
+RAA VRL++
Sbjct: 1662 LLRAASKTVRLVI 1674
Score = 38.9 bits (89), Expect = 0.007
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 176 GQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
G FI SV P PA+ G L+ DR++ VN V +EG H + ++ ++ L++
Sbjct: 929 GIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984
Score = 38.5 bits (88), Expect = 0.009
Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 116 APGQAEPPAAAEVQGAGNE-------NEPREAD---------KSHPEQRELRPRLC-TMK 158
APGQ+ P + + + +EP + ++H E EL L T+
Sbjct: 1542 APGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLI 1601
Query: 159 KGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVV 216
K G GF + + G ++ V D PA++ G L+ DR+++VN + H D V
Sbjct: 1602 KSEKGSLGFTVTKGNQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAV 1660
Query: 217 SAIRAGGDETKLLV 230
+ +RA +L++
Sbjct: 1661 NLLRAASKTVRLVI 1674
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 74.7 bits (182), Expect = 1e-13
Identities = 84/321 (26%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPE 94
G Y++ V P AE G + GDR++ VNG ++E TH+Q V +R V LL+ +
Sbjct: 1394 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ 1453
Query: 95 TDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRL 154
+ + + V + L Q A GQ Q K + E
Sbjct: 1454 SPTSKEHVPV-TPQCTLSDQNAQGQGPEKVKKTTQ-----------VKDYSFVTEENTFE 1501
Query: 155 CTMKKGPSGYGFNL-HSDKSKPGQF------IRSVDPDSPAEASG-LRAQDRIVEVNGVC 206
+ K SG GF+ D P Q ++ + P PA SG + D I++VNG
Sbjct: 1502 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 207 MEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQK 266
++G +V+SA+R E LL+ CR P G LP T
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLL-----------CRPPP------GVLPEIDTALLTPL 1604
Query: 267 ENSREALAEAALESPRPALVRSASSDTSEELNSQD-----SPPKQDSTAPSSTSSSDPIL 321
++ + L ++ +S +P+ V ++S E++ + SP ++DS + SS S D ++
Sbjct: 1605 QSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLV 1664
Query: 322 --DFNISLAMAKERAHQKRSS 340
NIS + HQ S+
Sbjct: 1665 TAPANISNSTWSSALHQTLSN 1685
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 7/85 (8%)
Query: 23 GYGFHLHG--EKGKL--GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQQVVS 77
G GF + G + G+L G +I V PG PA+ G L GDRL+ VN ++E +H +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 78 RIRAALNAVRLLVVDPETDEQLQKL 102
++ A V L++ P+ E++ K+
Sbjct: 1163 ILQNAPEDVTLVISQPK--EKISKV 1185
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 18 EKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77
EKG GF + ++G Y+ V L GDRL++VN +V TH V+
Sbjct: 1795 EKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1852
Query: 78 RIRAALNAVRLLV 90
+RAA VRL++
Sbjct: 1853 LLRAASKTVRLVI 1865
Score = 39.3 bits (90), Expect = 0.005
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 19/132 (14%)
Query: 115 EAPGQAEPPAAAEVQGAGNENEP---READKSHPE-------QRELRPRLCTMKKGPS-G 163
E PGQA + +GN + +E D H +RE+ L +KK G
Sbjct: 1047 EDPGQAYV-LGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREIT--LVNLKKDAKYG 1103
Query: 164 YGFNLHSDKSKP----GQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA 218
GF + + G FI SV P PA+ G L+ DR++ VN V +EG H +
Sbjct: 1104 LGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 1163
Query: 219 IRAGGDETKLLV 230
++ ++ L++
Sbjct: 1164 LQNAPEDVTLVI 1175
Score = 38.5 bits (88), Expect = 0.009
Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 116 APGQAEPPAAAEVQGAGNE-------NEPREAD---------KSHPEQRELRPRLC-TMK 158
APGQ+ P + + + +EP + ++H E EL L T+
Sbjct: 1733 APGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLI 1792
Query: 159 KGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVV 216
K G GF + + G ++ V D PA++ G L+ DR+++VN + H D V
Sbjct: 1793 KSEKGSLGFTVTKGNQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAV 1851
Query: 217 SAIRAGGDETKLLV 230
+ +RA +L++
Sbjct: 1852 NLLRAASKTVRLVI 1865
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 74.7 bits (182), Expect = 1e-13
Identities = 84/321 (26%), Positives = 134/321 (41%), Gaps = 45/321 (14%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPE 94
G Y++ V P AE G + GDR++ VNG ++E TH+Q V +R V LL+ +
Sbjct: 1375 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ 1434
Query: 95 TDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRL 154
+ + + V + L Q A GQ Q K + E
Sbjct: 1435 SPTSKEHVPV-TPQCTLSDQNAQGQGPEKVKKTTQ-----------VKDYSFVTEENTFE 1482
Query: 155 CTMKKGPSGYGFNL-HSDKSKPGQF------IRSVDPDSPAEASG-LRAQDRIVEVNGVC 206
+ K SG GF+ D P Q ++ + P PA SG + D I++VNG
Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 207 MEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQK 266
++G +V+SA+R E LL+ CR P G LP T
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLL-----------CRPPP------GVLPEIDTALLTPL 1585
Query: 267 ENSREALAEAALESPRPALVRSASSDTSEELNSQD-----SPPKQDSTAPSSTSSSDPIL 321
++ + L ++ +S +P+ V ++S E++ + SP ++DS + SS S D ++
Sbjct: 1586 QSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLV 1645
Query: 322 --DFNISLAMAKERAHQKRSS 340
NIS + HQ S+
Sbjct: 1646 TAPANISNSTWSSALHQTLSN 1666
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 7/85 (8%)
Query: 23 GYGFHLHG--EKGKL--GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQQVVS 77
G GF + G + G+L G +I V PG PA+ G L GDRL+ VN ++E +H +
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 78 RIRAALNAVRLLVVDPETDEQLQKL 102
++ A V L++ P+ E++ K+
Sbjct: 1144 ILQNAPEDVTLVISQPK--EKISKV 1166
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 18 EKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77
EKG GF + ++G Y+ V L GDRL++VN +V TH V+
Sbjct: 1776 EKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1833
Query: 78 RIRAALNAVRLLV 90
+RAA VRL++
Sbjct: 1834 LLRAASKTVRLVI 1846
Score = 38.9 bits (89), Expect = 0.007
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 176 GQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
G FI SV P PA+ G L+ DR++ VN V +EG H + ++ ++ L++
Sbjct: 1101 GIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156
Score = 38.5 bits (88), Expect = 0.009
Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 116 APGQAEPPAAAEVQGAGNE-------NEPREAD---------KSHPEQRELRPRLC-TMK 158
APGQ+ P + + + +EP + ++H E EL L T+
Sbjct: 1714 APGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLI 1773
Query: 159 KGPSG-YGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVV 216
K G GF + + G ++ V D PA++ G L+ DR+++VN + H D V
Sbjct: 1774 KSEKGSLGFTVTKGNQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAV 1832
Query: 217 SAIRAGGDETKLLV 230
+ +RA +L++
Sbjct: 1833 NLLRAASKTVRLVI 1846
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 73.9 bits (180), Expect = 2e-13
Identities = 65/236 (27%), Positives = 94/236 (39%), Gaps = 25/236 (10%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEK 69
L KGP G GF + G G YI + G A+K G L GDRL+ VN N++
Sbjct: 229 LLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQD 288
Query: 70 ETHQQVVSRIRAALNAVRLLVVDP---------------ETDEQLQKLGVQVREELLRAQ 114
H++ V+ ++ + V L V P T L + L
Sbjct: 289 VRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLG 348
Query: 115 EAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSK 174
+ PA +V PR RE PR + KG +G GFN+ +
Sbjct: 349 AVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTRE--PRKIILHKGSTGLGFNIVGGEDG 406
Query: 175 PGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLL 229
G F+ + PA+ SG LR DRI+ VNGV + H +A++ G ++
Sbjct: 407 EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Score = 57.4 bits (137), Expect = 2e-08
Identities = 32/109 (29%), Positives = 58/109 (53%), Gaps = 2/109 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR L KG G GF++ G + G ++ + G PA+ +G L GDR++ VNG N+
Sbjct: 384 PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNA 443
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPG 118
TH+Q + ++ A +V ++ PE + + +RE+++ + + G
Sbjct: 444 THEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSG 492
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 72.4 bits (176), Expect = 6e-13
Identities = 60/229 (26%), Positives = 107/229 (46%), Gaps = 24/229 (10%)
Query: 29 HGEKGKLGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVR 87
+GE+ K G +I+ V SPA K L GD+++EV+G +++ +H + V I+ A N V
Sbjct: 1095 NGEELK-GIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV 1153
Query: 88 LLV--------VDPETDEQLQKL------GVQVREELLRAQEAPGQAEPPAAAEVQGAGN 133
+V V P + K+ Q ++E + P PP + +
Sbjct: 1154 FIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSD 1213
Query: 134 ENEPREA---DKSHPEQRELRPRL--CTMKKGPSGYGFNL--HSDKSKPGQFIRSVDPDS 186
ENE +A K +L L ++K +G G +L + D+S+ F+ ++P+
Sbjct: 1214 ENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEG 1273
Query: 187 PAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRE 234
PA A G +R D ++E+N + G+ H + + I+ + KL+ + E
Sbjct: 1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNE 1322
Score = 68.9 bits (167), Expect = 6e-12
Identities = 75/297 (25%), Positives = 130/297 (43%), Gaps = 37/297 (12%)
Query: 22 NGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIR 80
+G GF + G K G +R + PG A++ G L GD ++++ G NV+ T +QV +R
Sbjct: 256 SGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 81 AALNAVRLLVV-DPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEV---QGAGNEN- 135
N+VR+LV DP D + P A P A +G G+++
Sbjct: 315 NCGNSVRMLVARDPAGDISVTP---------------PAPAALPVALPTVASKGPGSDSS 359
Query: 136 --EPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASG- 192
E + + + L R+ GY H+ ++ G +++S+ P S A +G
Sbjct: 360 LFETYNVELVRKDGQSLGIRIV-------GYVGTSHTGEAS-GIYVKSIIPGSAAYHNGH 411
Query: 193 LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLN 252
++ D+IV V+GV ++G + DVV +R G L +V R+T + +
Sbjct: 412 IQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVV 471
Query: 253 GPL--PVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQD 307
PL P F G ++ E + + E E R +++ + E+L P+ +
Sbjct: 472 EPLKPPALFLTGAVETETNVDGEDEEIKE--RIDTLKNDNIQALEKLEKVPDSPENE 526
Score = 53.1 bits (126), Expect = 4e-07
Identities = 59/251 (23%), Positives = 101/251 (40%), Gaps = 19/251 (7%)
Query: 18 EKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQQVV 76
+K G G + G++ G +I + G A+ G L+ GD+++ VNGE++ + + V
Sbjct: 1538 KKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVA 1597
Query: 77 SRIRAALNAVRL----LVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAG 132
+ ++ A V+L L T + Q + Q A P A + G
Sbjct: 1598 TILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQ-----QSAHSSCHPSFAPVITGLQ 1652
Query: 133 N-ENEPREADKSHPEQ-RELRPRLCTMKKGPS-GYGFNLHSDKSKP----GQFIRSVDPD 185
N R +D S ++ PR + + S G ++ + P FI +
Sbjct: 1653 NLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQAS 1712
Query: 186 S-PAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIR-AGGDETKLLVVDRETDEFFKKCR 243
A L+ DRIV +NG ++G H DVV+ ++ A G +V D +
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLE 1772
Query: 244 VIPSQEHLNGP 254
+ + HL P
Sbjct: 1773 NMSTGYHLGSP 1783
Score = 52.4 bits (124), Expect = 6e-07
Identities = 62/275 (22%), Positives = 107/275 (38%), Gaps = 61/275 (22%)
Query: 17 LEKGPNGYGFHLHGEK--GKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQ 73
LEK NG G L G K ++ ++ + P PA G + GD L+E+N + + +HQ
Sbjct: 1242 LEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301
Query: 74 QVVSRIRAALNAVRLLVV------------------------------DPETDEQLQKLG 103
+ I+ A + V+L+ + +P + E+ +
Sbjct: 1302 NASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVE 1361
Query: 104 VQVRE-----------ELLRAQEAP-----GQAEPPAA---------AEVQGAGNENEPR 138
V +++ ++ Q+ P E P A A+ G G P
Sbjct: 1362 VGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPL 1421
Query: 139 EADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKP--GQFIRSVDPDSPAEASG-LRA 195
D + + + + KG SG G ++ K P I V + A G L A
Sbjct: 1422 SVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWA 1481
Query: 196 QDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
D+I+EVNGV + H + ++A+R + +L+V
Sbjct: 1482 GDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
Score = 50.1 bits (118), Expect = 3e-06
Identities = 35/130 (26%), Positives = 61/130 (46%), Gaps = 6/130 (4%)
Query: 168 LHSDKSKPGQFIRSVDPDSPA-EASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDET 226
L + + G FI+ V DSPA + + L+ D+I+EV+GV ++ H + V AI+ G+
Sbjct: 1093 LKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Query: 227 KLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALV 286
+V + RVIP+ + + +K+ R+ A ++ P P
Sbjct: 1153 VFIVQSLSSTP-----RVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKA 1207
Query: 287 RSASSDTSEE 296
+ SD +EE
Sbjct: 1208 LTDDSDENEE 1217
Score = 43.5 bits (101), Expect = 3e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 7/100 (7%)
Query: 17 LEKGPNGYGFHLHGEKGKLGQYI---RLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQ 73
+ KG +G G + G K I + E G+ A L AGD+++EVNG ++ +H+
Sbjct: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499
Query: 74 QVVSRIRAALNAVRLLVVDPET----DEQLQKLGVQVREE 109
+ ++ +R VRL+V E +E L+ V ++++
Sbjct: 1500 EAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKK 1539
Score = 41.2 bits (95), Expect = 0.001
Identities = 48/191 (25%), Positives = 82/191 (42%), Gaps = 20/191 (10%)
Query: 38 YIRLVEPGSPAEKAGLLAG-DRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETD 96
YI + G P + GLL D L+EVNG + ++ ++ VS ++ L+ D
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 97 EQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCT 156
++ +E R + + + E +V E++ E PE + +
Sbjct: 642 DEASV------DEPRRTETSLPETEVDHNMDVNT--EEDDDGELALWSPEVK-----IVE 688
Query: 157 MKKGPSGYGFNL--HSDKSKPGQ---FIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGK 210
+ K G GF++ + D P + IRS+ D AE SG L DR+V VN C++
Sbjct: 689 LVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNT 748
Query: 211 QHGDVVSAIRA 221
+ V ++A
Sbjct: 749 SLAEAVEILKA 759
Score = 37.0 bits (84), Expect = 0.027
Identities = 50/239 (20%), Positives = 88/239 (36%), Gaps = 61/239 (25%)
Query: 36 GQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVV--- 91
G Y++ + PGS A G + D++V V+G N++ + VV +R A V L +V
Sbjct: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK 453
Query: 92 -----------------------------------------DPETDEQLQKL---GVQVR 107
D E E++ L +Q
Sbjct: 454 TSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQAL 513
Query: 108 EELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPR-----LCTMKKGPS 162
E+L + ++P + G E D + EL+ + T++ G
Sbjct: 514 EKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVE 573
Query: 163 GYGFNLHSDKSKPGQFIRSVDPDSPAEASGL-RAQDRIVEVNGVCMEGKQHGDVVSAIR 220
F+ H +I S+ P + GL + +D ++EVNG+ + GK + VS ++
Sbjct: 574 VDSFDGH-------HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 72.0 bits (175), Expect = 8e-13
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 15/224 (6%)
Query: 6 AAGAPLPRLCCLE--KGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVE 61
+AG RL L K G GF + G E G +G Y+ LVEPGS AEK GL GD+++
Sbjct: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHG-VGIYVSLVEPGSLAEKEGLRVGDQILR 190
Query: 62 VNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAE 121
VN +++ + TH + V AL + LV+ + ++ G V + + G++
Sbjct: 191 VNDKSLARVTHAEAVK----ALKGSKKLVLSVYSAGRIP--GGYVTNHIYTWVDPQGRSI 244
Query: 122 PPAAAEVQGAGNENEPREADKS---HPEQRELRPRLCTMKKGPSGYGFNLHSDKSKP-GQ 177
P + Q G +E D+ H Q ++ + G + G
Sbjct: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGI 304
Query: 178 FIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRA 221
+I VDP S AE SGL+ D+I+EVNG H + V +++
Sbjct: 305 YITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348
Score = 43.1 bits (100), Expect = 4e-04
Identities = 21/57 (36%), Positives = 35/57 (61%)
Query: 30 GEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAV 86
G + LG YI V+PGS AE +GL GD+++EVNG + H + V ++++ + +
Sbjct: 297 GAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 71.2 bits (173), Expect = 1e-12
Identities = 65/259 (25%), Positives = 104/259 (40%), Gaps = 38/259 (14%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEK 69
L KGP G GF + G G Y+ + G A+K G L GDRL+ VN ++E+
Sbjct: 145 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQ---------VREELLRAQE----- 115
TH++ V+ ++ V L V P T G + LL
Sbjct: 205 VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEY 264
Query: 116 -------APGQAEP-PAAAEVQGAGNENEPREADKSHPEQR-------ELRPRLCTMKKG 160
+PG+ P P V + P E PR + KG
Sbjct: 265 KTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKG 324
Query: 161 PSGYGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAI 219
+G GFN+ + G F+ + PA+ SG L+ D+I+ VNG+ + G H +A+
Sbjct: 325 STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 384
Query: 220 RAGGDETKLLVVDRETDEF 238
+ G +T ++ + +++
Sbjct: 385 KGAG-QTVTIIAQYQPEDY 402
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 2/109 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR L KG G GF++ G + G ++ + G PA+ +G L GD+++ VNG ++
Sbjct: 316 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 375
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPG 118
+H+Q + ++ A V ++ PE + + +RE+++ + G
Sbjct: 376 SHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSG 424
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 70.9 bits (172), Expect = 2e-12
Identities = 65/250 (26%), Positives = 101/250 (40%), Gaps = 43/250 (17%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEK 69
L KGP G GF + G G Y+ + G A K G L GD+++ VN +E
Sbjct: 206 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLED 265
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPE-------------TDEQLQKLGVQVREELLRAQEA 116
H+ V+ ++ + V L V P T Q L ++ +
Sbjct: 266 VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDY 325
Query: 117 PGQAEP-------PAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH 169
P P P A ++ G E+ PRE PR + +G +G GFN+
Sbjct: 326 PTAMTPTSPRRYSPVAKDL--LGEEDIPRE------------PRRIVIHRGSTGLGFNIV 371
Query: 170 SDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKL 228
+ G FI + PA+ SG LR D+I+ VNGV + H A++ G +T
Sbjct: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAG-QTVT 430
Query: 229 LVVDRETDEF 238
++ + +E+
Sbjct: 431 IIAQYKPEEY 440
Score = 50.4 bits (119), Expect = 2e-06
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR + +G G GF++ G + G +I + G PA+ +G L GD+++ VNG ++
Sbjct: 354 PRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPGQA 120
+H+Q ++ A V ++ PE + + +RE+L+ + G A
Sbjct: 414 SHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 464
Score = 41.2 bits (95), Expect = 0.001
Identities = 53/228 (23%), Positives = 88/228 (38%), Gaps = 66/228 (28%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQ----YIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEK 69
LE+G +G GF + G + +G +I + PG A + G L D ++ VN +V +
Sbjct: 111 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 170
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
TH V ++ A + VRL V+ + +PPA ++
Sbjct: 171 VTHSAAVEALKEAGSIVRLYVM---------------------------RRKPPAEKVME 203
Query: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH---SDKSKPGQ---FIRSVD 183
+ KGP G GF++ ++ PG ++ +
Sbjct: 204 -------------------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 238
Query: 184 PDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
A G L+ D+I+ VN V +E H D V+A++ D L V
Sbjct: 239 EGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 70.9 bits (172), Expect = 2e-12
Identities = 65/250 (26%), Positives = 101/250 (40%), Gaps = 43/250 (17%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEK 69
L KGP G GF + G G Y+ + G A K G L GD+++ VN +E
Sbjct: 160 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLED 219
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPE-------------TDEQLQKLGVQVREELLRAQEA 116
H+ V+ ++ + V L V P T Q L ++ +
Sbjct: 220 VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDY 279
Query: 117 PGQAEP-------PAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH 169
P P P A ++ G E+ PRE PR + +G +G GFN+
Sbjct: 280 PTAMTPTSPRRYSPVAKDL--LGEEDIPRE------------PRRIVIHRGSTGLGFNIV 325
Query: 170 SDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKL 228
+ G FI + PA+ SG LR D+I+ VNGV + H A++ G +T
Sbjct: 326 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAG-QTVT 384
Query: 229 LVVDRETDEF 238
++ + +E+
Sbjct: 385 IIAQYKPEEY 394
Score = 50.4 bits (119), Expect = 2e-06
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR + +G G GF++ G + G +I + G PA+ +G L GD+++ VNG ++
Sbjct: 308 PRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 367
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPGQA 120
+H+Q ++ A V ++ PE + + +RE+L+ + G A
Sbjct: 368 SHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 418
Score = 41.2 bits (95), Expect = 0.001
Identities = 53/228 (23%), Positives = 88/228 (38%), Gaps = 66/228 (28%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQ----YIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEK 69
LE+G +G GF + G + +G +I + PG A + G L D ++ VN +V +
Sbjct: 65 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
TH V ++ A + VRL V+ + +PPA ++
Sbjct: 125 VTHSAAVEALKEAGSIVRLYVM---------------------------RRKPPAEKVME 157
Query: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH---SDKSKPGQ---FIRSVD 183
+ KGP G GF++ ++ PG ++ +
Sbjct: 158 -------------------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 192
Query: 184 PDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
A G L+ D+I+ VN V +E H D V+A++ D L V
Sbjct: 193 EGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 69.3 bits (168), Expect = 5e-12
Identities = 63/236 (26%), Positives = 98/236 (41%), Gaps = 38/236 (16%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEK 69
L KGP G GF + G G Y+ + G A K G L GD+L+ VN +E+
Sbjct: 322 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE 381
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPE-------------TDEQLQKLGVQVREELLRAQ-- 114
TH++ V+ ++ + V L V P T+ Q + V Q
Sbjct: 382 VTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTP 441
Query: 115 EAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSK 174
+P + P + A + G++ RE PR + +G +G GFN+ +
Sbjct: 442 ASPARYSPVSKAVL---GDDEITRE------------PRKVVLHRGSTGLGFNIVGGEDG 486
Query: 175 PGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLL 229
G FI + PA+ SG LR DRI+ VN V + H +A++ G ++
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIV 542
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 2/109 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR L +G G GF++ G + G +I + G PA+ +G L GDR++ VN ++
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPG 118
+H+Q + ++ A AV ++ PE + + +RE+++ + + G
Sbjct: 524 SHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSG 572
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/228 (21%), Positives = 87/228 (38%), Gaps = 66/228 (28%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQ-----YIRLVEPGSPAEKAGLLAGDRLVEVNGENVEK 69
LE+G +G GF + G + +G +++ G+ A+ L D ++ VN +V
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
TH + V ++ A + VRL V K V E+++ +
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV----------KRRKPVSEKIMEIK--------------- 321
Query: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH---SDKSKPGQ---FIRSVD 183
+ KGP G GF++ ++ PG ++ +
Sbjct: 322 ---------------------------LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 184 PDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
A G L+ D+++ VN VC+E H + V+A++ D L V
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 69.3 bits (168), Expect = 5e-12
Identities = 63/236 (26%), Positives = 98/236 (41%), Gaps = 38/236 (16%)
Query: 17 LEKGPNGYGFHLHGEKGKL------GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEK 69
L KGP G GF + G G Y+ + G A K G L GD+L+ VN +E+
Sbjct: 322 LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE 381
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPE-------------TDEQLQKLGVQVREELLRAQ-- 114
TH++ V+ ++ + V L V P T+ Q + V Q
Sbjct: 382 VTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTP 441
Query: 115 EAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSK 174
+P + P + A + G++ RE PR + +G +G GFN+ +
Sbjct: 442 ASPARYSPVSKAVL---GDDEITRE------------PRKVVLHRGSTGLGFNIVGGEDG 486
Query: 175 PGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLL 229
G FI + PA+ SG LR DRI+ VN V + H +A++ G ++
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIV 542
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 2/109 (1%)
Query: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKE 70
PR L +G G GF++ G + G +I + G PA+ +G L GDR++ VN ++
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 71 THQQVVSRIRAALNAVRLLV-VDPETDEQLQKLGVQVREELLRAQEAPG 118
+H+Q + ++ A AV ++ PE + + +RE+++ + + G
Sbjct: 524 SHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSG 572
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/228 (21%), Positives = 87/228 (38%), Gaps = 66/228 (28%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQ-----YIRLVEPGSPAEKAGLLAGDRLVEVNGENVEK 69
LE+G +G GF + G + +G +++ G+ A+ L D ++ VN +V
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
TH + V ++ A + VRL V K V E+++ +
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV----------KRRKPVSEKIMEIK--------------- 321
Query: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLH---SDKSKPGQ---FIRSVD 183
+ KGP G GF++ ++ PG ++ +
Sbjct: 322 ---------------------------LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 184 PDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
A G L+ D+++ VN VC+E H + V+A++ D L V
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 69.3 bits (168), Expect = 5e-12
Identities = 65/271 (23%), Positives = 118/271 (43%), Gaps = 25/271 (9%)
Query: 40 RLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQ 98
R++E GSPA++ G L GDR++ VNG ++ ++H +V+ I+ A N V L ++ +
Sbjct: 1011 RIIE-GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN 1069
Query: 99 LQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREAD----KSHPEQRELRPRL 154
L + + P Q Q N +P++ K+ +E
Sbjct: 1070 ATLLTNAEKIATITTTHTPSQ------QGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1123
Query: 155 CTMKKGPSGYGFNLHSDKS-KPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQH 212
+++G G+GF+L + ++ + D PAE G +R D I+E+NG + +H
Sbjct: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
Query: 213 GDVVSAIRAGGDETKLLVV--DRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSR 270
+ I+ GG +L + D E+ PS + +GP P E++ R
Sbjct: 1184 SRAIELIKNGGRRVRLFLKRGDGSVPEY------DPSSDR-HGPATGPQGVPEVRAGPDR 1236
Query: 271 EALAEAALESPRPALVRSASSDTSEELNSQD 301
+LES P + +S + +++D
Sbjct: 1237 R--QHPSLESSYPPDLHKSSPHGEKRAHARD 1265
Score = 52.4 bits (124), Expect = 6e-07
Identities = 90/376 (23%), Positives = 133/376 (35%), Gaps = 81/376 (21%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
L K G+GF + G E + Q LV G A + GD +V VN V TH Q
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 75 VVSRIRAALNAVRL---------LVVDPETDEQLQKLGVQVREE---LLRAQE---APGQ 119
VV ++ + L DP+ V + ++ ++ QE +P
Sbjct: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
Query: 120 -------------AEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMK--KGPSGY 164
A P + A+V + P + S +P L T+ KGP G+
Sbjct: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT-VSLASSIATQPELITVHIVKGPMGF 653
Query: 165 GFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAI--RAG 222
GF + GQ ++ + DSP GL+ D IVEVN ++ H VV +
Sbjct: 654 GFTIADSPGGGGQRVKQI-VDSP-RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 223 GDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPR 282
G E LLV G LPVP +SP+
Sbjct: 712 GSEVTLLV--------------------QRGGLPVP-------------------KKSPK 732
Query: 283 PALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPIL-DFNISLAMAKERAHQKRSSK 341
+ S S SQ S S +S S S +L +F + A A ++ K
Sbjct: 733 SQPLERKDSQNS----SQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKK 788
Query: 342 RAPQMDWSKKNELFSN 357
P W++ ++ N
Sbjct: 789 PDPFKIWAQSRSMYEN 804
Score = 47.8 bits (112), Expect = 2e-05
Identities = 68/294 (23%), Positives = 120/294 (40%), Gaps = 42/294 (14%)
Query: 19 KGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
KGP G+GF + G GQ ++ + GL GD +VEVN +NV+ TH QVV
Sbjct: 648 KGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQALTHNQVVDM 705
Query: 79 IRAAL--NAVRLLV----------------VDPETDEQLQKLGVQVREELLRAQEAPGQA 120
+ + V LLV ++ + + + V L A +
Sbjct: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
Query: 121 E----PPAAAEVQGAGNENEPREAD--------KSHPEQR--ELRPRLCTMKKGPSGYGF 166
PPA A+ + + ++ D +S E R + + + + + +G+GF
Sbjct: 766 VLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGF 825
Query: 167 NLHSDKSKPGQ--FIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGG 223
+ ++PG+ +I + P A+ G LR+ D ++ V+G + GK H VV ++
Sbjct: 826 RILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAA 884
Query: 224 DETKL-LVVDRETDEFFKKCR---VIPSQEHLNGPLPVPFTNGEIQKENSREAL 273
+ + L V R+ K P+ H + P T + + S+ +L
Sbjct: 885 KQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 938
Score = 47.0 bits (110), Expect = 3e-05
Identities = 67/273 (24%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 23 GYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIR 80
G+GF + G E G+ +V G+ L +GD L+ V+G V ++HQ VV ++
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 881
Query: 81 AALN------AVRLLVVD--PETDEQLQKLGVQVREE-----LLRAQEAPGQAEPPAAAE 127
A VR VV P+T+ ++ L + P ++
Sbjct: 882 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 941
Query: 128 VQGAGNENEPREADK--SHPEQRELRPRLCTMKKGPS-GYGFNLHSDKSKPG-------- 176
G+G+ + S ++P +++G + G+GF + S S+P
Sbjct: 942 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1001
Query: 177 -----QFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
I + SPA+ G L+ DRI+ VNG + K H D+V+ I+ G+ L
Sbjct: 1002 CVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL-- 1059
Query: 231 VDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGE 263
R+IP E N L TN E
Sbjct: 1060 ------------RIIPGDESSNATL---LTNAE 1077
Score = 46.6 bits (109), Expect = 3e-05
Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 17 LEKGPNGYGFHLHGEKG-KLGQYI-RLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQ 73
LE+G G+GF L G + + Y+ RL E G PAE+ G + GD ++E+NGE + H
Sbjct: 1126 LERGAKGFGFSLRGGREYNMDLYVLRLAEDG-PAERCGKMRIGDEILEINGETTKNMKHS 1184
Query: 74 QVVSRIRAALNAVRLLV---------VDPETDEQLQKLGVQ 105
+ + I+ VRL + DP +D G Q
Sbjct: 1185 RAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQ 1225
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 68.9 bits (167), Expect = 6e-12
Identities = 50/198 (25%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 40 RLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQ 98
R++E GSPA++ G L GDR++ VNG ++ ++H +V+ I+ A N V L ++ +
Sbjct: 1040 RIIE-GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN 1098
Query: 99 LQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREAD----KSHPEQRELRPRL 154
L + + P Q Q N +P++ K+ +E
Sbjct: 1099 ATLLTNAEKIATITTTHTPSQ------QGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1152
Query: 155 CTMKKGPSGYGFNLHSDKS-KPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQH 212
+++G G+GF+L + ++ + D PAE G +R D I+E+NG + +H
Sbjct: 1153 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1212
Query: 213 GDVVSAIRAGGDETKLLV 230
+ I+ GG +L +
Sbjct: 1213 SRAIELIKNGGRRVRLFL 1230
Score = 52.4 bits (124), Expect = 6e-07
Identities = 90/376 (23%), Positives = 133/376 (35%), Gaps = 81/376 (21%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
L K G+GF + G E + Q LV G A + GD +V VN V TH Q
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 75 VVSRIRAALNAVRL---------LVVDPETDEQLQKLGVQVREE---LLRAQE---APGQ 119
VV ++ + L DP+ V + ++ ++ QE +P
Sbjct: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
Query: 120 -------------AEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMK--KGPSGY 164
A P + A+V + P + S +P L T+ KGP G+
Sbjct: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT-VSLASSIATQPELITVHIVKGPMGF 653
Query: 165 GFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAI--RAG 222
GF + GQ ++ + DSP GL+ D IVEVN ++ H VV +
Sbjct: 654 GFTIADSPGGGGQRVKQI-VDSP-RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 223 GDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPR 282
G E LLV G LPVP +SP+
Sbjct: 712 GSEVTLLV--------------------QRGGLPVP-------------------KKSPK 732
Query: 283 PALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPIL-DFNISLAMAKERAHQKRSSK 341
+ S S SQ S S +S S S +L +F + A A ++ K
Sbjct: 733 SQPLERKDSQNS----SQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKK 788
Query: 342 RAPQMDWSKKNELFSN 357
P W++ ++ N
Sbjct: 789 PDPFKIWAQSRSMYEN 804
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/274 (24%), Positives = 108/274 (39%), Gaps = 50/274 (18%)
Query: 23 GYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIR 80
G+GF + G E G+ +V G+ L +GD L+ V+G V ++HQ VV ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 81 AALN------AVRLLVVD--PETDEQLQKLGVQVREE-----LLRAQEAPGQAEPPAAAE 127
A VR VV P+T+ ++ L + P ++
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 128 VQGAGNENEPREADK--SHPEQRELRPRLCTMKKGPS-GYGFNLHSDKSKPG-------- 176
G+G+ + S ++P +++G + G+GF + S S+P
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGN 1029
Query: 177 ------QFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLL 229
I + SPA+ G L+ DRI+ VNG + K H D+V+ I+ G+ L
Sbjct: 1030 ACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL- 1088
Query: 230 VVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGE 263
R+IP E N L TN E
Sbjct: 1089 -------------RIIPGDESSNATL---LTNAE 1106
Score = 46.2 bits (108), Expect = 4e-05
Identities = 28/77 (36%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 17 LEKGPNGYGFHLHGEKG-KLGQYI-RLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQ 73
LE+G G+GF L G + + Y+ RL E G PAE+ G + GD ++E+NGE + H
Sbjct: 1155 LERGAKGFGFSLRGGREYNMDLYVLRLAEDG-PAERCGKMRIGDEILEINGETTKNMKHS 1213
Query: 74 QVVSRIRAALNAVRLLV 90
+ + I+ VRL +
Sbjct: 1214 RAIELIKNGGRRVRLFL 1230
Score = 45.1 bits (105), Expect = 1e-04
Identities = 55/198 (27%), Positives = 81/198 (40%), Gaps = 33/198 (16%)
Query: 19 KGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
KGP G+GF + G GQ ++ + GL GD +VEVN +NV+ TH QVV
Sbjct: 648 KGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQALTHNQVVD- 704
Query: 79 IRAALNAVRLLVVDPETDEQ---LQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNEN 135
+LV P+ E +Q+ G+ V ++ ++Q P + + + +
Sbjct: 705 ---------MLVECPKGSEVTLLVQRGGLPVPKKSPKSQ--PLERKDSQNSSQHSVSSHR 753
Query: 136 EPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQF-----IRSV---DPD 185
A SH Q E P G + KP F RS+ P
Sbjct: 754 SLHTASPSHSTQVLPEFPPAEAQAPDQTDSSG------QKKPDPFKIWAQSRSMYENRPM 807
Query: 186 SPAEASGLRAQDRIVEVN 203
SP+ ASGL +R E+N
Sbjct: 808 SPSPASGLSKGEREREIN 825
Score = 28.5 bits (62), Expect = 9.7
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 162 SGYGFNLHSDKSKPGQ--FIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA 218
+G+GF + ++PG+ +I + P A+ G LR+ D ++ V+G + GK H VV
Sbjct: 849 TGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQL 907
Query: 219 IRAGGDETKL-LVVDRETDEFFKKCR---VIPSQEHLNGPLPVPFTNGEIQKENSREAL 273
++ + + L V R+ K P+ H + P T + + S+ +L
Sbjct: 908 MQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 966
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 68.9 bits (167), Expect = 6e-12
Identities = 50/198 (25%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 40 RLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQ 98
R++E GSPA++ G L GDR++ VNG ++ ++H +V+ I+ A N V L ++ +
Sbjct: 1039 RIIE-GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN 1097
Query: 99 LQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREAD----KSHPEQRELRPRL 154
L + + P Q Q N +P++ K+ +E
Sbjct: 1098 ATLLTNAEKIATITTTHTPSQ------QGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1151
Query: 155 CTMKKGPSGYGFNLHSDKS-KPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQH 212
+++G G+GF+L + ++ + D PAE G +R D I+E+NG + +H
Sbjct: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
Query: 213 GDVVSAIRAGGDETKLLV 230
+ I+ GG +L +
Sbjct: 1212 SRAIELIKNGGRRVRLFL 1229
Score = 52.4 bits (124), Expect = 6e-07
Identities = 90/376 (23%), Positives = 133/376 (35%), Gaps = 81/376 (21%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
L K G+GF + G E + Q LV G A + GD +V VN V TH Q
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 75 VVSRIRAALNAVRL---------LVVDPETDEQLQKLGVQVREE---LLRAQE---APGQ 119
VV ++ + L DP+ V + ++ ++ QE +P
Sbjct: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
Query: 120 -------------AEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMK--KGPSGY 164
A P + A+V + P + S +P L T+ KGP G+
Sbjct: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT-VSLASSIATQPELITVHIVKGPMGF 653
Query: 165 GFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAI--RAG 222
GF + GQ ++ + DSP GL+ D IVEVN ++ H VV +
Sbjct: 654 GFTIADSPGGGGQRVKQI-VDSP-RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 223 GDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPR 282
G E LLV G LPVP +SP+
Sbjct: 712 GSEVTLLV--------------------QRGGLPVP-------------------KKSPK 732
Query: 283 PALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPIL-DFNISLAMAKERAHQKRSSK 341
+ S S SQ S S +S S S +L +F + A A ++ K
Sbjct: 733 SQPLERKDSQNS----SQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKK 788
Query: 342 RAPQMDWSKKNELFSN 357
P W++ ++ N
Sbjct: 789 PDPFKIWAQSRSMYEN 804
Score = 47.0 bits (110), Expect = 3e-05
Identities = 67/273 (24%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 23 GYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIR 80
G+GF + G E G+ +V G+ L +GD L+ V+G V ++HQ VV ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 81 AALN------AVRLLVVD--PETDEQLQKLGVQVREE-----LLRAQEAPGQAEPPAAAE 127
A VR VV P+T+ ++ L + P ++
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 128 VQGAGNENEPREADK--SHPEQRELRPRLCTMKKGPS-GYGFNLHSDKSKPG-------- 176
G+G+ + S ++P +++G + G+GF + S S+P
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1029
Query: 177 -----QFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
I + SPA+ G L+ DRI+ VNG + K H D+V+ I+ G+ L
Sbjct: 1030 CVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL-- 1087
Query: 231 VDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGE 263
R+IP E N L TN E
Sbjct: 1088 ------------RIIPGDESSNATL---LTNAE 1105
Score = 46.2 bits (108), Expect = 4e-05
Identities = 28/77 (36%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 17 LEKGPNGYGFHLHGEKG-KLGQYI-RLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQ 73
LE+G G+GF L G + + Y+ RL E G PAE+ G + GD ++E+NGE + H
Sbjct: 1154 LERGAKGFGFSLRGGREYNMDLYVLRLAEDG-PAERCGKMRIGDEILEINGETTKNMKHS 1212
Query: 74 QVVSRIRAALNAVRLLV 90
+ + I+ VRL +
Sbjct: 1213 RAIELIKNGGRRVRLFL 1229
Score = 45.1 bits (105), Expect = 1e-04
Identities = 55/198 (27%), Positives = 81/198 (40%), Gaps = 33/198 (16%)
Query: 19 KGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
KGP G+GF + G GQ ++ + GL GD +VEVN +NV+ TH QVV
Sbjct: 648 KGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQALTHNQVVD- 704
Query: 79 IRAALNAVRLLVVDPETDEQ---LQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNEN 135
+LV P+ E +Q+ G+ V ++ ++Q P + + + +
Sbjct: 705 ---------MLVECPKGSEVTLLVQRGGLPVPKKSPKSQ--PLERKDSQNSSQHSVSSHR 753
Query: 136 EPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQF-----IRSV---DPD 185
A SH Q E P G + KP F RS+ P
Sbjct: 754 SLHTASPSHSTQVLPEFPPAEAQAPDQTDSSG------QKKPDPFKIWAQSRSMYENRPM 807
Query: 186 SPAEASGLRAQDRIVEVN 203
SP+ ASGL +R E+N
Sbjct: 808 SPSPASGLSKGEREREIN 825
Score = 28.5 bits (62), Expect = 9.7
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 162 SGYGFNLHSDKSKPGQ--FIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA 218
+G+GF + ++PG+ +I + P A+ G LR+ D ++ V+G + GK H VV
Sbjct: 849 TGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQL 907
Query: 219 IRAGGDETKL-LVVDRETDEFFKKCR---VIPSQEHLNGPLPVPFTNGEIQKENSREAL 273
++ + + L V R+ K P+ H + P T + + S+ +L
Sbjct: 908 MQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 966
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 66.6 bits (161), Expect = 3e-11
Identities = 68/240 (28%), Positives = 95/240 (39%), Gaps = 35/240 (14%)
Query: 14 LCCLEKGPNGYGFHLHGEKGK-------LGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGE 65
+ CL + G GF + G KG G ++ + G A +AG L GDR++ +NG
Sbjct: 862 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 66 NVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAA 125
+V + H VS + AA + LL+ ++ G + L P A +
Sbjct: 922 DVTEARHDHAVSLLTAASPTIALLLE--------REAGGPLPPSPLPHSSPPTAAVATTS 973
Query: 126 AEVQGAGNENEPREA--------DKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKS---- 173
G P A + +P + PR GP G SD S
Sbjct: 974 ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR----AGGPLGLSIVGGSDHSSHPF 1029
Query: 174 ---KPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
+PG FI V P A SGLR DRI+ VNG + H + VSA+ E LLV
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/242 (27%), Positives = 96/242 (39%), Gaps = 54/242 (22%)
Query: 36 GQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPET 95
G +I V P A ++GL GDR++ VNG++V THQ+ VS + + LLV
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094
Query: 96 DEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA--GNENEPREADKSHPEQRELRPR 153
L++L + Q+APG+ ++G G+ PR
Sbjct: 1095 PPGLRELCI---------QKAPGER---LGISIRGGARGHAGNPR--------------- 1127
Query: 154 LCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQH 212
D + G FI V P A G LR R++EVN + G H
Sbjct: 1128 -----------------DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 213 GDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREA 272
G+ V +R+ GD +LV D V P G + PF G I NS E+
Sbjct: 1171 GEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAG-IGHRNSLES 1223
Query: 273 LA 274
++
Sbjct: 1224 IS 1225
Score = 56.2 bits (134), Expect = 4e-08
Identities = 57/231 (24%), Positives = 95/231 (41%), Gaps = 37/231 (16%)
Query: 23 GYGFHLHGEKGKL-------GQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQV 75
G G + G KG G +I V PA +AG+ GD+L+EVNG ++ H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 76 VSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA----PGQAEPPAAAEVQGA 131
V +R A AV++ V RE ++ + A P + E + +
Sbjct: 797 VEALRGAGTAVQMRV---------------WRERMVEPENAVTITPLRPEDDYSPRERRG 841
Query: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSK-------PGQFIRSVDP 184
G P +S R+ + + + G GF++ K G F+ +
Sbjct: 842 GGLRLPLLPPESPGPLRQ--RHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAE 899
Query: 185 DSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRE 234
A +G L+ DR++ +NGV + +H VS + A T L+++RE
Sbjct: 900 GGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTA-ASPTIALLLERE 949
Score = 52.8 bits (125), Expect = 5e-07
Identities = 36/146 (24%), Positives = 68/146 (46%), Gaps = 11/146 (7%)
Query: 93 PETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAG-NENEPREADKSHPEQRELR 151
P+ +E+ ++ + EE +E + +A V+G ++ + + E+ EL
Sbjct: 669 PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELT 728
Query: 152 PRLCTMKKGPSGYGFNLHSDKSKP-------GQFIRSVDPDSPAEASGLRAQDRIVEVNG 204
T+ + G G ++ K G FI V + PA +G+R D+++EVNG
Sbjct: 729 ---LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNG 785
Query: 205 VCMEGKQHGDVVSAIRAGGDETKLLV 230
V ++G +H + V A+R G ++ V
Sbjct: 786 VALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 32.7 bits (73), Expect = 0.51
Identities = 85/357 (23%), Positives = 131/357 (36%), Gaps = 59/357 (16%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVD-- 92
G +I V P A + G L G RL+EVN +++ TH + V +R+ + + +LV D
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1192
Query: 93 -PETDEQLQ----------KLGVQVREELL---------------RAQEAPGQAEPPAAA 126
TD L+ G+ R L + +E PGQ
Sbjct: 1193 EASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPE 1252
Query: 127 EVQGAGNENEPREADKSHPEQRELR--PRLCTMKKGPSGY--GFNLHSDKSKPGQFIRSV 182
+ AG +P + D R L P ++++ PSG G S S GQ +
Sbjct: 1253 ATEAAGRGLQPLKLD-----YRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQ--QPP 1305
Query: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242
P SP E + V G + + RE ++F+
Sbjct: 1306 SPPSPDELPA-NVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELE 1364
Query: 243 RVIPSQEHLNGPLPVPFTNGE----IQKENSR-------EALAEAALESPRPALVRSASS 291
+P E P V + +Q+E +R + L EAA L +
Sbjct: 1365 VRVPQAE--GPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARL--ALDG 1420
Query: 292 DTSEELNSQDSPPKQDSTAPSSTSS--SDPILDFNISLAMAK-ERAHQKRSSKRAPQ 345
+T E +D P S +P+S S S P L + AK ER HQ+R ++P+
Sbjct: 1421 ETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPE 1477
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 66.6 bits (161), Expect = 3e-11
Identities = 68/240 (28%), Positives = 95/240 (39%), Gaps = 35/240 (14%)
Query: 14 LCCLEKGPNGYGFHLHGEKGK-------LGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGE 65
+ CL + G GF + G KG G ++ + G A +AG L GDR++ +NG
Sbjct: 862 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 66 NVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAA 125
+V + H VS + AA + LL+ ++ G + L P A +
Sbjct: 922 DVTEARHDHAVSLLTAASPTIALLLE--------REAGGPLPPSPLPHSSPPTAAVATTS 973
Query: 126 AEVQGAGNENEPREA--------DKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKS---- 173
G P A + +P + PR GP G SD S
Sbjct: 974 ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR----AGGPLGLSIVGGSDHSSHPF 1029
Query: 174 ---KPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
+PG FI V P A SGLR DRI+ VNG + H + VSA+ E LLV
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/242 (27%), Positives = 96/242 (39%), Gaps = 54/242 (22%)
Query: 36 GQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPET 95
G +I V P A ++GL GDR++ VNG++V THQ+ VS + + LLV
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094
Query: 96 DEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA--GNENEPREADKSHPEQRELRPR 153
L++L + Q+APG+ ++G G+ PR
Sbjct: 1095 PPGLRELCI---------QKAPGER---LGISIRGGARGHAGNPR--------------- 1127
Query: 154 LCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQH 212
D + G FI V P A G LR R++EVN + G H
Sbjct: 1128 -----------------DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 213 GDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREA 272
G+ V +R+ GD +LV D V P G + PF G I NS E+
Sbjct: 1171 GEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAG-IGHRNSLES 1223
Query: 273 LA 274
++
Sbjct: 1224 IS 1225
Score = 56.2 bits (134), Expect = 4e-08
Identities = 57/231 (24%), Positives = 95/231 (41%), Gaps = 37/231 (16%)
Query: 23 GYGFHLHGEKGKL-------GQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQV 75
G G + G KG G +I V PA +AG+ GD+L+EVNG ++ H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 76 VSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA----PGQAEPPAAAEVQGA 131
V +R A AV++ V RE ++ + A P + E + +
Sbjct: 797 VEALRGAGTAVQMRV---------------WRERMVEPENAVTITPLRPEDDYSPRERRG 841
Query: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSK-------PGQFIRSVDP 184
G P +S R+ + + + G GF++ K G F+ +
Sbjct: 842 GGLRLPLLPPESPGPLRQ--RHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAE 899
Query: 185 DSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRE 234
A +G L+ DR++ +NGV + +H VS + A T L+++RE
Sbjct: 900 GGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTA-ASPTIALLLERE 949
Score = 52.8 bits (125), Expect = 5e-07
Identities = 36/146 (24%), Positives = 68/146 (46%), Gaps = 11/146 (7%)
Query: 93 PETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAG-NENEPREADKSHPEQRELR 151
P+ +E+ ++ + EE +E + +A V+G ++ + + E+ EL
Sbjct: 669 PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELT 728
Query: 152 PRLCTMKKGPSGYGFNLHSDKSKP-------GQFIRSVDPDSPAEASGLRAQDRIVEVNG 204
T+ + G G ++ K G FI V + PA +G+R D+++EVNG
Sbjct: 729 ---LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNG 785
Query: 205 VCMEGKQHGDVVSAIRAGGDETKLLV 230
V ++G +H + V A+R G ++ V
Sbjct: 786 VALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 32.7 bits (73), Expect = 0.51
Identities = 85/357 (23%), Positives = 131/357 (36%), Gaps = 59/357 (16%)
Query: 36 GQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVD-- 92
G +I V P A + G L G RL+EVN +++ TH + V +R+ + + +LV D
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1192
Query: 93 -PETDEQLQ----------KLGVQVREELL---------------RAQEAPGQAEPPAAA 126
TD L+ G+ R L + +E PGQ
Sbjct: 1193 EASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPE 1252
Query: 127 EVQGAGNENEPREADKSHPEQRELR--PRLCTMKKGPSGY--GFNLHSDKSKPGQFIRSV 182
+ AG +P + D R L P ++++ PSG G S S GQ +
Sbjct: 1253 ATEAAGRGLQPLKLD-----YRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQ--QPP 1305
Query: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242
P SP E + V G + + RE ++F+
Sbjct: 1306 SPPSPDELPA-NVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELE 1364
Query: 243 RVIPSQEHLNGPLPVPFTNGE----IQKENSR-------EALAEAALESPRPALVRSASS 291
+P E P V + +Q+E +R + L EAA L +
Sbjct: 1365 VRVPQAE--GPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARL--ALDG 1420
Query: 292 DTSEELNSQDSPPKQDSTAPSSTSS--SDPILDFNISLAMAK-ERAHQKRSSKRAPQ 345
+T E +D P S +P+S S S P L + AK ER HQ+R ++P+
Sbjct: 1421 ETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPE 1477
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 66.2 bits (160), Expect = 4e-11
Identities = 66/243 (27%), Positives = 101/243 (41%), Gaps = 31/243 (12%)
Query: 19 KGPNGYGFHLHGEKGK-----LGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETH 72
K G+GF + K K + I V GSPA++ G L GD + VNG+++ + +H
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 73 QQVVSRIRAALNAVRLLVVDPE--------TDEQLQKLGVQVREE-LLRAQEAPGQAEPP 123
+V I+ A V L V+ E T+ Q +Q R +A PG
Sbjct: 917 DNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSAL 976
Query: 124 AAAEVQGAGNENEPREADKSHPEQ--------------RELRPRLCTMKKGPSGYGFNLH 169
+ +D H Q + L +++GP G+GF+L
Sbjct: 977 EGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLR 1036
Query: 170 SDKS-KPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETK 227
K G FI + D PA G + D+IVE+NG +G H + I+AGG++
Sbjct: 1037 GGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 228 LLV 230
LL+
Sbjct: 1097 LLL 1099
Score = 56.6 bits (135), Expect = 3e-08
Identities = 63/223 (28%), Positives = 91/223 (40%), Gaps = 47/223 (21%)
Query: 17 LEKGPNGYGFHLHGEKG-KLGQYI-RLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
LE+GP G+GF L G K +G +I RL E G + + GD++VE+NGE + TH +
Sbjct: 1024 LERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTR 1083
Query: 75 VVSRIRAALNAVRLLVVDPET---------------------DEQ------------LQK 101
+ I+A N V LL++ P T DEQ ++
Sbjct: 1084 AIELIQAGGNKV-LLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEE 1142
Query: 102 LGVQVREELLRAQEAPGQAE-PPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKG 160
V V EE LR Q E E + NEN+P +S L + + +
Sbjct: 1143 SHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQS------LLQKNVSKRDP 1196
Query: 161 PSGYGFNLHSDKSKPGQFI----RSVDPDSPAEASGLRAQDRI 199
PS +G + + K + RSV P PA D+I
Sbjct: 1197 PSSHGHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKI 1239
Score = 55.8 bits (133), Expect = 6e-08
Identities = 60/248 (24%), Positives = 108/248 (43%), Gaps = 26/248 (10%)
Query: 5 AAAGAPLPRLCCLE--KGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEV 62
A++G+ P L + KGP G+GF + GQ ++++ + GL GD + E+
Sbjct: 567 ASSGSSQPELVTIPLIKGPKGFGFAI--ADSPTGQKVKMILDSQWCQ--GLQKGDIIKEI 622
Query: 63 NGENVEKETHQQVVSRIR----AALNAVRLLVVDPETDEQLQKLGVQVRE---ELLRAQE 115
+NV+ TH QVV ++ A + +L P + + K+ +E L E
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 116 APGQAEPPAAAEVQGAGNENEPREA--------DKSHPEQRELRPRLCTMKKGPSGYGFN 167
Q P + ++ + +P E + P ++L ++K SG+GF
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD---VFLRKQESGFGFR 739
Query: 168 -LHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDE 225
L D +I ++ P AE G LRA D ++ ++G+ ++GK H V+ +
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
Query: 226 TKLLVVDR 233
+L+ R
Sbjct: 800 GHVLLTVR 807
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 139 EADKSH----PEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQF--IRSVDPDSPAEASG 192
+ +KSH P Q + ++KK G+GF + +P +F +++V D PA G
Sbjct: 391 DMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDG 449
Query: 193 LRAQ-DRIVEVNGVCMEGKQHGDVV 216
A D IV++NG C+ G H DVV
Sbjct: 450 KIAPGDVIVDINGNCVLGHTHADVV 474
Score = 35.8 bits (81), Expect = 0.061
Identities = 60/283 (21%), Positives = 100/283 (35%), Gaps = 49/283 (17%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
L+K G+GF + G + Q +++ G A+ + GD +V++NG V TH
Sbjct: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 75 VVSR-----IRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA--------PGQAE 121
VV + +N D + + + ++ Q P +
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFK 532
Query: 122 PPAAAEVQ-----------GAGNENEPREADKSHPEQRELRPRLCTMK--KGPSGYGFNL 168
P A Q G ++ E S +P L T+ KGP G+GF +
Sbjct: 533 PGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAI 592
Query: 169 HSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIR-------- 220
S GQ ++ + + GL+ D I E+ ++ H VV ++
Sbjct: 593 AD--SPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADV 648
Query: 221 -----AGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVP 258
GG + +TD K S E +N P+P P
Sbjct: 649 PLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQP 687
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 66.2 bits (160), Expect = 4e-11
Identities = 66/243 (27%), Positives = 101/243 (41%), Gaps = 31/243 (12%)
Query: 19 KGPNGYGFHLHGEKGK-----LGQYIRLVEPGSPAEKAGLL-AGDRLVEVNGENVEKETH 72
K G+GF + K K + I V GSPA++ G L GD + VNG+++ + +H
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 73 QQVVSRIRAALNAVRLLVVDPE--------TDEQLQKLGVQVREE-LLRAQEAPGQAEPP 123
+V I+ A V L V+ E T+ Q +Q R +A PG
Sbjct: 917 DNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSAL 976
Query: 124 AAAEVQGAGNENEPREADKSHPEQ--------------RELRPRLCTMKKGPSGYGFNLH 169
+ +D H Q + L +++GP G+GF+L
Sbjct: 977 EGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLR 1036
Query: 170 SDKS-KPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETK 227
K G FI + D PA G + D+IVE+NG +G H + I+AGG++
Sbjct: 1037 GGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 228 LLV 230
LL+
Sbjct: 1097 LLL 1099
Score = 55.8 bits (133), Expect = 6e-08
Identities = 60/248 (24%), Positives = 108/248 (43%), Gaps = 26/248 (10%)
Query: 5 AAAGAPLPRLCCLE--KGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEV 62
A++G+ P L + KGP G+GF + GQ ++++ + GL GD + E+
Sbjct: 567 ASSGSSQPELVTIPLIKGPKGFGFAI--ADSPTGQKVKMILDSQWCQ--GLQKGDIIKEI 622
Query: 63 NGENVEKETHQQVVSRIR----AALNAVRLLVVDPETDEQLQKLGVQVRE---ELLRAQE 115
+NV+ TH QVV ++ A + +L P + + K+ +E L E
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 116 APGQAEPPAAAEVQGAGNENEPREA--------DKSHPEQRELRPRLCTMKKGPSGYGFN 167
Q P + ++ + +P E + P ++L ++K SG+GF
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD---VFLRKQESGFGFR 739
Query: 168 -LHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDE 225
L D +I ++ P AE G LRA D ++ ++G+ ++GK H V+ +
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
Query: 226 TKLLVVDR 233
+L+ R
Sbjct: 800 GHVLLTVR 807
Score = 55.1 bits (131), Expect = 1e-07
Identities = 31/76 (40%), Positives = 45/76 (59%), Gaps = 2/76 (2%)
Query: 17 LEKGPNGYGFHLHGEKG-KLGQYI-RLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
LE+GP G+GF L G K +G +I RL E G + + GD++VE+NGE + TH +
Sbjct: 1024 LERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTR 1083
Query: 75 VVSRIRAALNAVRLLV 90
+ I+A N V LL+
Sbjct: 1084 AIELIQAGGNKVLLLL 1099
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 139 EADKSH----PEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQF--IRSVDPDSPAEASG 192
+ +KSH P Q + ++KK G+GF + +P +F +++V D PA G
Sbjct: 391 DMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDG 449
Query: 193 LRAQ-DRIVEVNGVCMEGKQHGDVV 216
A D IV++NG C+ G H DVV
Sbjct: 450 KIAPGDVIVDINGNCVLGHTHADVV 474
Score = 35.8 bits (81), Expect = 0.061
Identities = 60/283 (21%), Positives = 100/283 (35%), Gaps = 49/283 (17%)
Query: 17 LEKGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQ 74
L+K G+GF + G + Q +++ G A+ + GD +V++NG V TH
Sbjct: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 75 VVSR-----IRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEA--------PGQAE 121
VV + +N D + + + ++ Q P +
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFK 532
Query: 122 PPAAAEVQ-----------GAGNENEPREADKSHPEQRELRPRLCTMK--KGPSGYGFNL 168
P A Q G ++ E S +P L T+ KGP G+GF +
Sbjct: 533 PGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAI 592
Query: 169 HSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIR-------- 220
S GQ ++ + + GL+ D I E+ ++ H VV ++
Sbjct: 593 AD--SPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADV 648
Query: 221 -----AGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVP 258
GG + +TD K S E +N P+P P
Sbjct: 649 PLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQP 687
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 63.5 bits (153), Expect = 3e-10
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 34/228 (14%)
Query: 21 PNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
P G G + G E G G +I + G A+ GL GD +V +NG ++ TH++V++
Sbjct: 95 PEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINL 153
Query: 79 IRAALNAVRLLVVDPETDEQLQKLGVQVRE-ELLRAQEAPGQAEPPAAAEVQGAGNENEP 137
IR + + ++VR L+ + +P EP V +E+
Sbjct: 154 IRTK-----------------KTVSIKVRHIGLIPVKSSPD--EPLTWQYVDQFVSESGG 194
Query: 138 READKSHPEQRELRPRLCTMKK-GPSGYGFNLHSDK-SKPGQFIRSVDPDSPAEASGLRA 195
P RE + + + G G G ++ S KPG FI V P S + GL
Sbjct: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEI 254
Query: 196 QDRIVEVNGVCMEGKQHGDVVSAIRAGGDET---------KLLVVDRE 234
D+IVEVNGV H + V+ +++ T +L + DRE
Sbjct: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRE 302
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 63.5 bits (153), Expect = 3e-10
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 34/228 (14%)
Query: 21 PNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
P G G + G E G G +I + G A+ GL GD +V +NG ++ TH++V++
Sbjct: 95 PEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINL 153
Query: 79 IRAALNAVRLLVVDPETDEQLQKLGVQVRE-ELLRAQEAPGQAEPPAAAEVQGAGNENEP 137
IR + + ++VR L+ + +P EP V +E+
Sbjct: 154 IRTK-----------------KTVSIKVRHIGLIPVKSSPD--EPLTWQYVDQFVSESGG 194
Query: 138 READKSHPEQRELRPRLCTMKK-GPSGYGFNLHSDK-SKPGQFIRSVDPDSPAEASGLRA 195
P RE + + + G G G ++ S KPG FI V P S + GL
Sbjct: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEI 254
Query: 196 QDRIVEVNGVCMEGKQHGDVVSAIRAGGDET---------KLLVVDRE 234
D+IVEVNGV H + V+ +++ T +L + DRE
Sbjct: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRE 302
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/229 (25%), Positives = 96/229 (41%), Gaps = 15/229 (6%)
Query: 17 LEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQQV 75
+ KG + G + K LG +R + G + G +A GD ++ +N E+ T+ Q
Sbjct: 1011 IAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQA 1070
Query: 76 VSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAP------GQAEPPAAAEVQ 129
+ +R + + E L++ + + ++ R G+ P +
Sbjct: 1071 RAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREE 1130
Query: 130 GAGNENEPREADKSHPEQ-------RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSV 182
G G E+E + S+ Q RE L G G G L + + G FI+ V
Sbjct: 1131 GEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHV 1190
Query: 183 DPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLV 230
DSPA +G L+ DRIVEV+G+ + H V AIR G+ +V
Sbjct: 1191 LEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Score = 58.9 bits (141), Expect = 7e-09
Identities = 90/366 (24%), Positives = 149/366 (40%), Gaps = 44/366 (12%)
Query: 22 NGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQQVVSRIR 80
+G G L G +IR V P P +G L +GD L+EVNG + E HQ VV+ ++
Sbjct: 563 SGLGISLEATVGH--HFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
Query: 81 AALNAVRLL----VVDPETDEQLQKL---GVQVREEL---LRAQEAPGQAEPPAAAEVQG 130
V ++ V P T +L L +++ E+ L + E P A +
Sbjct: 621 ELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLA-MTD 679
Query: 131 AGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNL--HSDKSKPGQ---FIRSVDPD 185
AG E +A + E + ++KG G GF++ + D P IRS+ P
Sbjct: 680 AGQSTEEVQAPLA---MWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPG 736
Query: 186 SPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRV 244
AE G L DR++ VN V +E + V A++ T + V + ++ V
Sbjct: 737 GIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYV 796
Query: 245 IPSQEHLNGP-----------LPVPFTNGEIQKENSREALAEAALESP----RPALVRSA 289
++ P P+ + + N + + E+ ESP ++ +
Sbjct: 797 SAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQ 856
Query: 290 SSDTSEELNSQDSPPKQDSTAPSS------TSSSDPILDFNISLAMAKERAHQKRSSKRA 343
+S S +S S+ PSS +S DP+LD ++SL + +R +
Sbjct: 857 ASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENT 916
Query: 344 PQMDWS 349
P +D S
Sbjct: 917 PSVDIS 922
Score = 58.9 bits (141), Expect = 7e-09
Identities = 67/292 (22%), Positives = 120/292 (41%), Gaps = 35/292 (11%)
Query: 17 LEKGPNGYGFHLHGEK--GKLGQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKETHQ 73
LEKG +G G L G K ++ +I ++P A K G L D L+E+NG+ + +HQ
Sbjct: 1353 LEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQ 1412
Query: 74 QVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGN 133
S I+ A + V+++ + + + ++ V PG A P + + N
Sbjct: 1413 NASSIIKCAPSKVKIIFI--RNKDAVNQMAV-----------CPGNAVEPLPSNSENLQN 1459
Query: 134 -ENEP--READKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEA 190
E EP +D + + + K G G + + + G I+S+ A
Sbjct: 1460 KETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAAT 1519
Query: 191 SG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQE 249
G L+ D+I+ V+ + G +S ++ KL + D + +PS
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDS-----QAVPS-- 1572
Query: 250 HLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQD 301
+GE K+NS ++L SP P +R+ S ++ + + D
Sbjct: 1573 ------AAGAASGE--KKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
Score = 57.8 bits (138), Expect = 1e-08
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 32/226 (14%)
Query: 17 LEKGP-NGYGFHLHGEKGK-LGQ---YIRLVEP-GSPAEKAGLLAGDRLVEVNGENVEKE 70
++KGP + G + G G LG +I ++ P G A+ L GDR+V + G + E
Sbjct: 1836 MKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGM 1895
Query: 71 THQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQG 130
TH Q V+ ++ A ++ + VV G V G + PA++ +
Sbjct: 1896 THTQAVNLLKNASGSIEMQVV----------AGGDV-------SVVTGHQQEPASSSLSF 1938
Query: 131 AGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQ----FIRSVDPDS 186
G + D P Q + T+++GP G GF++ P ++++V
Sbjct: 1939 TGLTSSSIFQDDLGPPQ----CKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKG 1994
Query: 187 PAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVV 231
A G L+ D+I+ VNG +EG H + V+ ++ L+V+
Sbjct: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/89 (32%), Positives = 50/89 (56%), Gaps = 5/89 (5%)
Query: 8 GAPLPRLCCLEKGPNGYGFHLHG----EKGKLGQYIRLV-EPGSPAEKAGLLAGDRLVEV 62
G P + LE+GP+G GF + G G L Y++ V G+ +E L GD+++ V
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAV 2011
Query: 63 NGENVEKETHQQVVSRIRAALNAVRLLVV 91
NG+++E TH++ V+ ++ V L+V+
Sbjct: 2012 NGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/242 (24%), Positives = 102/242 (42%), Gaps = 39/242 (16%)
Query: 17 LEKGPNGYGFHLHGEKG--KL---GQYIRLVEPGSPAEKAGLLA-GDRLVEVNGENVEKE 70
L K G G + G G KL G +++ + S E G + GD+++ V+G N++
Sbjct: 380 LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
Query: 71 THQQVVSRIRAALNAVRLLVV--------------DPETDEQLQKLGVQVREELLRAQE- 115
T+QQ V +R V L ++ D D L + + +E E
Sbjct: 440 TNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDED 499
Query: 116 ----------APGQAE--PPAAAEVQGAGNENEPREADKSHPEQRELRPR----LCTMKK 159
P + E P +AE++ + + +EA QR + + + K
Sbjct: 500 FLSSTRNTNILPTEEEGYPLLSAEIEEI-EDAQKQEAALLTKWQRIMGINYEIVVAHVSK 558
Query: 160 GPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA 218
G + + + FIRSV P+ P SG L + D ++EVNG+ + G+ H DVV+
Sbjct: 559 FSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 219 IR 220
++
Sbjct: 619 LK 620
Score = 48.5 bits (114), Expect = 9e-06
Identities = 53/226 (23%), Positives = 89/226 (39%), Gaps = 48/226 (21%)
Query: 17 LEKGPN-GYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQQ 74
L+K P G G + G++ G ++ + G A+ G L+ GD+++ VNGE+V T +
Sbjct: 1728 LQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEA 1787
Query: 75 VVSRIR---AALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA 131
V + ++ +L++ + T E L+ + A+E+QG
Sbjct: 1788 VAALLKVSEGSLSSFTFPLSGSSTSESLES----------------SSKKNALASEIQGL 1831
Query: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPS-GYGFNLHSDKSKP----GQFIRSVDPDS 186
R MKKGP+ G ++ P FI + P
Sbjct: 1832 ---------------------RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTG 1870
Query: 187 -PAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVV 231
A+ LR DRIV + G EG H V+ ++ ++ VV
Sbjct: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
Score = 48.1 bits (113), Expect = 1e-05
Identities = 55/256 (21%), Positives = 109/256 (42%), Gaps = 36/256 (14%)
Query: 22 NGYGFHLHGEKGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEVNGENVEKETHQQVVSRIR 80
+G GF + G K G ++ + PG A++ G L +GD ++++ ++ + +QV +R
Sbjct: 265 SGLGFGIIGGKAT-GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 81 AALNAVRLLVVDPETDEQL--QKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPR 138
N V+L++ +E+ LG+ + + P + E++ + +
Sbjct: 324 QCGNRVKLMIARGAIEERTAPTALGITL------------SSSPTSTPELRVDASTQKGE 371
Query: 139 EADKSHPEQRELRPRLCTMKKGPSGYGFN----LHSDKSKP-GQFIRSVDPDSPAEASG- 192
E++ E + K G G + K +P G F++S+ S E G
Sbjct: 372 ESETFDVE----------LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGR 421
Query: 193 LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLN 252
++ D+I+ V+G ++G + V +R G L ++ R K+ + S+E +
Sbjct: 422 IQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG----MKQEAELMSREDVT 477
Query: 253 GPLPVPFTNGEIQKEN 268
+ N I KEN
Sbjct: 478 KDADLSPVNASIIKEN 493
Score = 42.4 bits (98), Expect = 6e-04
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 6/106 (5%)
Query: 17 LEKGPNGYGFHLHGEKGKL-GQYI--RLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQ 73
+ KG G G + G L G I + E G+ + L AGD+++EVNG ++ K TH
Sbjct: 1632 ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHD 1691
Query: 74 QVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQ 119
+ ++ +R VRL + E + +++ + EL Q+ PG+
Sbjct: 1692 EAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIEL---QKKPGK 1734
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 11/222 (4%)
Query: 17 LEKGPNGYGFHLHGEKGKLGQYIR-LVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQV 75
L K G G + E G I+ L E G A L GD+++ V+ E V ++
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 76 VSRIRAALNAVRLLVVDPETDEQL--QKLGVQVREELLRAQEAP-GQAEPPAAAEVQGAG 132
+S ++ A V+L + D Q G E+ +Q Q+ P ++
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605
Query: 133 NENEPREADKSHPEQRELRPRLCT---MKKGPSGYGFNL--HSDKSKPGQFIRSVDPDSP 187
+ P S P + P T + KG +G G ++ SD I V +
Sbjct: 1606 RSSTPA-IFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGA 1664
Query: 188 AEASG-LRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKL 228
A G L A D+I+EVNG+ + H + ++ +R +L
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 61.6 bits (148), Expect = 1e-09
Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 13/103 (12%)
Query: 2 SADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQ-------------YIRLVEPGSPA 48
+ + G PR+ + K +GYGF++ G+ + GQ ++ V PG A
Sbjct: 31 AGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAA 90
Query: 49 EKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVV 91
++AG+ GDR++EVN NVE TH+QVV IRA + L V+
Sbjct: 91 DRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
Score = 58.2 bits (139), Expect = 1e-08
Identities = 36/93 (38%), Positives = 48/93 (51%), Gaps = 13/93 (13%)
Query: 152 PRLCTMKKGPSGYGFNLHSDKSKPGQF-------------IRSVDPDSPAEASGLRAQDR 198
PR+ + K SGYGFN+ S+ GQ + +V P A+ +G+R DR
Sbjct: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
Query: 199 IVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVV 231
I+EVN V +EG H VV IRAG E L V+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
sapiens]
Length = 2161
Score = 59.7 bits (143), Expect = 4e-09
Identities = 40/110 (36%), Positives = 55/110 (50%), Gaps = 17/110 (15%)
Query: 18 EKGPNGYGFHLHGEKGKLG-------------QYIRLVEPGSPAEKAGLLAGDRLVEVNG 64
+K G+GF L G K + QY+ V+ G A +AGL GD L+EVNG
Sbjct: 668 KKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNG 727
Query: 65 ENVEKETHQQVVSRIRAALNAVRLLVV----DPETDEQLQKLGVQVREEL 110
+NV K H+QVV+ IR N + + VV P+ DE + K Q + L
Sbjct: 728 QNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRL 777
Score = 43.1 bits (100), Expect = 4e-04
Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 15/94 (15%)
Query: 158 KKGPSGYGFNLHSDKSKPG-------------QFIRSVDPDSPAEASGLRAQDRIVEVNG 204
KK G+GF L K++ Q++ SVD A +GLR D ++EVNG
Sbjct: 668 KKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNG 727
Query: 205 VCMEGKQHGDVVSAIRAGGDE--TKLLVVDRETD 236
+ H VV+ IR GG+ K+++V R D
Sbjct: 728 QNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPD 761
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,554,344
Number of Sequences: 37866
Number of extensions: 782655
Number of successful extensions: 3945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 3082
Number of HSP's gapped (non-prelim): 807
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.